Document Document Title
US08872239B2 Image pickup device
An image pickup device according to the present invention is an image pickup device in which a plurality of pixel are arranged in a semiconductor substrate. Each of the plurality of pixels includes a photoelectric conversion element, a floating diffusion (FD) region, a transfer gate that transfers charges in the first semiconductor region to the FD region, and an amplification transistor whose gate is electrically connected to the FD region. The photoelectric conversion element has an outer edge which has a recessed portion in plan view, a source region and a drain region of the amplification transistor are located in the recessed portion, and the FD region is surrounded by the photoelectric conversion region or is located in the recessed portion in plan view.
US08872238B2 Method for manufacturing a low defect interface between a dielectric and a III-V compound
The present invention is related to a method for manufacturing a low defect interface between a dielectric material and an III-V compound. More specifically, the present invention relates to a method for manufacturing a passivated interface between a dielectric material and an III-V compound. The present invention is also directed to a device comprising a low defect interface between a dielectric material and an III-V compound that has improved performance.
US08872236B2 Scaling of bipolar transistors
Bipolar transistor structures, methods of designing and fabricating bipolar transistors, methods of designing circuits having bipolar transistors. The method of designing the bipolar transistor includes: selecting an initial design of a bipolar transistor; scaling the initial design of the bipolar transistor to generate a scaled design of the bipolar transistor; determining if stress compensation of the scaled design of the bipolar transistor is required based on dimensions of an emitter of the bipolar transistor after the scaling; and if stress compensation of the scaled design of the bipolar transistor is required then adjusting a layout of a trench isolation layout level of the scaled design relative to a layout of an emitter layout level of the scaled design to generate a stress compensated scaled design of the bipolar transistor.
US08872235B2 Integrated Schottky diode for HEMTs
An embodiment of a transistor device includes a compound semiconductor material on a semiconductor carrier and a source region and a drain region spaced apart from each other in the compound semiconductor material with a channel region interposed between the source and drain regions. A Schottky diode is integrated with the semiconductor carrier, and contacts extend from the source and drain regions through the compound semiconductor material. The contacts are in electrical contact with the Schottky diode so that the Schottky diode is connected in parallel between the source and drain regions. In another embodiment, the integrated Schottky diode is formed by a region of doped amorphous silicon or doped polycrystalline silicon disposed in a trench structure on the drain side of the device.
US08872230B2 Tunnel field-effect transistor and methods for manufacturing thereof
A tunnel Field Effect Transistor is provided comprising an interface between a source and a channel, the source side of this interface being a layer of a first crystalline semiconductor material being substantially uniformly doped with a metal to the solubility level of the metal in the first crystalline material and the channel side of this interface being a layer of this first crystalline semiconductor material doped with this metal, the concentration decreasing towards the channel.
US08872221B2 Vertical thin film transistor and fabricating method thereof
A vertical thin film transistor includes a substrate, a first wall, a second wall, a source electrode, a drain electrode, a semiconductor layer, a gate insulating layer, and a gate electrode. The first wall and the second walls are spaced apart from each other on the substrate. The source electrode is formed on a top surface of the first wall. The drain electrode is provided on the substrate between the first and second walls. The semiconductor layer is formed on the source electrode, a sidewall of the first wall, and the drain electrode. The gate insulating layer covers the first and second walls, the source and drain electrodes, and the semiconductor layer. The gate electrode is disposed between the first and second walls in a planar view. The vertical thin film transistor may be formed without a mask.
US08872219B2 Multi-dimensional solid state lighting device array system and associated methods and structures
A multi-dimensional solid state lighting (SSL) device array system and method are disclosed. An SSL device includes a support, a pillar having several sloped facets mounted to the support, and a flexible substrate pressed against the pillar. The substrate can carry a plurality of solid state emitters (SSEs) facing in various directions corresponding to the sloped facets of the pillar. The flexible substrate can be a flat substrate prepared using planar mounting techniques, such as wirebonding techniques, before bending the substrate against the pillar.
US08872218B2 Molded package and light emitting device
A molded package, including: a molded resin having a recess for accommodating a light emitting element; and a lead disposed at a bottom of the molded resin, a part of one surface of the lead being exposed from a bottom surface of the recess of the molded resin, the other surface of the lead including an exposed part and a lead recess, the exposed part being exposed from a rear surface of the molded resin, the lead recess being filled with a resin fully covering an inner surface thereof, the lead including a cutout or a through hole extending from the one surface to the other surface, a first edge of the cutout or the through hole closer to a center of the recess at the other surface being located inside the lead recess and covered with the resin.
US08872217B2 Electronic device contact structures
Electronic devices involving contact structures, and related components, systems and methods associated therewith are described. The contact structures are particularly suitable for use in a variety of light-emitting devices, including LEDs.
US08872214B2 Rod-like light-emitting device, method of manufacturing rod-like light-emitting device, backlight, illuminating device, and display device
To facilitate electrode connections and achieve a high light emitting efficiency, a rod-like light-emitting device includes a semiconductor core of a first conductivity type having a rod shape, and a semiconductor layer of a second conductivity type formed to cover the semiconductor core. The outer peripheral surface of part of the semiconductor core is exposed.
US08872212B2 Light emitting device, light emitting device package comprising the same and lighting system
A light emitting device including a light emitting structure including a first conductive semiconductor layer, an active layer and a second conductive semiconductor layer, a first electrode disposed on the first conductive semiconductor layer, a conductive layer disposed on the second conductive semiconductor layer, a second electrode disposed on the conductive layer, a channel layer directly contacts with the light emitting structure and disposed at an adjacent region of the second electrode, a support substrate disposed on the channel layer, and wherein the conductive layer is separated into at least two unit conductive layers.
US08872204B2 Light-emitting device having a trench in a semiconductor layer
A light-emitting device comprises a substrate, an epitaxial structure formed on the substrate including a first semiconductor layer, a second semiconductor layer, and a light-emitting layer formed between the first semiconductor layer and the second semiconductor layer. A trench is formed in the epitaxial structure to expose a part of side surface of the epitaxial structure and a part of surface of the first semiconductor layer, so that a first conductive structure is formed on the part of surface of the first semiconductor layer in the trench, and a second conductive structure is formed on the second semiconductor layer. The first conductive structure includes a first electrode and a first pad electrically contacted with each other. The second conductive structure includes a second electrode and a second pad electrically contacted with each other. Furthermore, the area of at least one of the first pad and the second pad is between 1.5×104 μm2 and 6.2×104 μm2.
US08872203B2 Light-emitting device
In a semiconductor light-emitting device, light from a laser diode is output to the outside after the luminance of the light being enhanced. It includes a support body provided with lead terminals, one or more laser diodes mounted on the support body, a cylindrical reflector fixed to the support body to surround the laser diode(s) and provided with a light reflection surface formed on an inner surface thereof, and a cap placed to cover an opening distal end face of the reflector and held at an opening distal end part of the reflector, the cap being provided at a central part thereof with a solid fluorescent member including a fluorescent substance that is excited by the light from the laser diode and emits light different in colors from light emitted by the laser diode.
US08872202B2 Light-emitting device capable of improving the light-emitting efficiency
A light-emitting device including a substrate, a light emitting structure and a coarse structure is provided. The substrate has an upper surface and a lower surface opposite to each other, and an annular side surface connecting the upper surface and the lower surface. The light emitting structure is disposed on the upper surface of the substrate. The coarse structure is formed on the annular side surface of the substrate. A ratio of a thickness of the substrate and a thickness of the coarse structure is greater than or equal to 1 and less than or equal to 20. Therefore, the overall light-emitting efficiency of the light-emitting device may be improved.
US08872194B2 Light emitting device with enhanced pre-dip and method of manufacturing the same
An illumination device is disclosed. The illumination device includes a light source a pre-dip material that at least partially encapsulates the light source. The pre-dip material may include one or both of thermally-conductive particles and a cyclo-aliphatic composition. The pre-dip material may further include a resin and a hardener for the resin. Methods of manufacturing an illumination device are also disclosed.
US08872193B2 Silicon carbide semiconductor device and method for producing the same
The present invention provides a technique capable of realizing a silicon carbide semiconductor device having high performance and high reliability. By constituting a channel region by an n−-type, intrinsic, or p−-type channel region and a p+-type channel region, a high channel mobility and a high threshold voltage are realized. Further, by constituting a source region by an n+-type source region and an n++-type source region, and forming the n+-type source region between the p+-type channel region and the n++-type source region, an electric field in the p+-type channel region is relaxed to suppress deterioration of a gate insulating film, and also by electrically connecting a source wiring electrode to the n++-type source region, a contact resistance is decreased.
US08872191B2 Electronic circuit device
A normally-off type silicon carbide junction FET has a problem that the gate thereof is not easy to use due to inferiority in the characteristics of it. This problem occurs because in order to achieve normally-off, the gate voltage should be off at 0V and at the same time, the ON-state gate voltage should be suppressed to about 2.5V to prevent the passage of an electric current through a pn junction between gate and source. Accordingly, a range from the threshold voltage to the ON-state gate voltage is only from about 1 V to 2V and it is difficult to control the gate voltage. Provided in the present invention is an electronic circuit device obtained by coupling, to a gate of a normally-off type silicon carbide junction FET, an element having a capacitance equal to or a little smaller than the gate capacitance of the junction FET.
US08872187B2 Membrane having means for state monitoring
The invention relates to a membrane. Partly permeable membranes often have holes or perforations having a specific diameter to allow substances having a smaller particle diameter to pass through, but to hold back substances having a larger particle diameter. Such membranes are subject to wear primarily at the holes, i.e. cracks form which grow through the membrane proceeding from a hole. Particularly in the case of micromechanical membranes having holes having a small diameter in the range of 1 μm or less, it is very difficult to detect the state of the membrane, in particular whether the latter has cracks. Membranes having cracks can then undesirably allow passage even of those particles which should actually be held back. In medical or hygienic applications, the function can then be impaired.
US08872183B2 Three-dimensional semiconductor devices
Three-dimensional semiconductor devices are provided. The three-dimensional semiconductor device includes a substrate, a buffer layer on the substrate. The buffer layer includes a material having an etching selectivity relative to that of the substrate. A multi-layer stack including alternating insulation patterns and conductive patterns is provided on the buffer layer opposite the substrate. One or more active patterns respectively extend through the alternating insulation patterns and conductive patterns of the multi-layer stack and into the buffer layer. Related fabrication methods are also discussed.
US08872182B2 Liquid crystal display device and semiconductor device
By increasing an interval between electrodes which drives liquid crystals, a gradient of an electric field applied between the electrodes can be controlled and an optimal electric field can be applied between the electrodes. The invention includes a first electrode formed over a substrate, an insulating film formed over the substrate and the first electrode, a thin film transistor including a semiconductor film in which a source, a channel region, and a drain are formed over the insulating film, a second electrode located over the semiconductor film and the first electrode and including first opening patterns, and liquid crystals provided over the second electrode.
US08872181B2 Thin film transistor array substrate and method of manufacturing the same
A substrate includes an active layer, a gate electrode, source and drain electrodes, first and second insulating layers, a first line and a second line on a same layer as the gate electrode, the first line and the second line include a same material as the gate electrode and are aligned in a first direction, a third line crosses the first line, the third line is on a same layer as the source and drain electrodes, includes a same material as the source and drain electrodes, and is aligned in a second direction, a repair line on a same layer as the active layer, the repair line includes a same material as the active layer, a pixel electrode in the pixel region, and the pixel electrode is on a same layer as a lower electrode of the gate electrode and includes a same material as the lower electrode.
US08872173B2 Thin film transistor structure and array substrate using the same
A thin film transistor structure is provided. The thin film transistor structure includes a first transistor having a first active layer, a second transistor having a second active layer, a first protection layer contacting the first active layer, and a second protection layer contacting the second active layer. The oxygen contents of the first and the second protection layers are controlled to affect the oxygen vacancy number of the first and the second active layers to satisfy the various electronic requirements of the first and the second transistors.
US08872169B2 Light emitting element and light emitting device using the same
An object of the present invention is to provide a light emitting element having slight increase in driving voltage with accumulation of light emitting time. Another object of the invention is to provide a light emitting element having slight increase in resistance value with increase in film thickness. A light emitting element of the invention includes a first layer for generating holes, a second layer for generating electrons and a third layer comprising a light emitting substance between first and second electrodes. The first and third layers are in contact with the first and second electrodes, respectively. The second and third layers are connected to each other so as to inject electrons generated in the second layer into the third layer when applying the voltage to the light emitting element such that a potential of the second electrode is higher than that of the first electrode.
US08872167B2 Organic light-emitting device
An object of the present invention is to provide an organic light-emitting device, wherein light trapped in a substrate due to total reflection at the interface between air and a substrate is efficiently extracted to the air side.The organic light-emitting device includes: a transparent electrode; a counter electrode; a light-emitting layer interposed between the transparent electrode and the counter electrode; a front substrate which allows light from the light-emitting layer to exit to the outside from a surface of the front substrate on the opposite side to the light-emitting layer side; and a diffuse reflector which reflects light from the light-emitting layer, wherein the diffuse reflector is provided on a side surface of the front substrate and at a given position on a surface thereof.
US08872165B2 Thin film transistor array substrate, organic light emitting display device comprising the same, and method of manufacturing the same
A thin film transistor array substrate includes a thin film transistor including an activation layer, a gate electrode, source and drain electrodes, a first insulation layer between the activation layer and the gate electrode, and a second insulation layer between the gate electrode and the source and drain electrodes, a pixel electrode including a transparent conductive oxide, the pixel electrode being on a portion of the first insulation layer extending from the thin film transistor and being connected to one of the source and drain electrodes via an opening in the second insulation layer, a capacitor including a first electrode and a second electrode, the first electrode being on a same layer as the activation layer and including a transparent conductive oxide, and the second electrode being between the first and second insulation layers, and a third insulation layer covering the source and drain electrodes and exposing the pixel electrode.
US08872164B2 Organic el element
An organic light-emitting element includes an anode, a functional layer, and a hole injection layer between the anode and the functional layer. The functional layer contains an organic material. The hole injection layer injects holes to the functional layer. The hole injection layer comprises tungsten oxide and includes an occupied energy level that is approximately 1.8 electron volts to approximately 3.6 electron volts lower than a lowest energy level of a valence band of the hole injection layer in terms of binding energy.
US08872163B2 Fused ring compounds useful in organic thin-film transistors
A compound for an organic thin film transistor having a structure represented by the following formula (1): wherein R1 and R2, and R3 and R4 are respectively combined with each other to form an aromatic hydrocarbon ring having 6 to 60 carbon atoms or an aromatic heterocyclic ring having 3 to 60 carbon atoms; the ring being fused to the ring to which the groups are bonded, whereby the structure of the formula (1) has 5 or more aromatic rings that are fused; and the fused rings formed by R1 and R2, and R3 and R4 each may have a substituent.
US08872161B1 Integrate circuit with nanowires
The present disclosure provides an integrated circuit (IC). The IC includes a substrate having a metal-oxide-semiconductor (MOS) region. The IC further includes first gate, source and drain regions, having a first length, and second gate, source and drain regions, having a second length. A first nanowire set is disposed in the first gate region, the first nanowire set including a nanowire having a first diameter and connecting to a feature in the first source region and a feature in the first drain region. A second nanowire set is disposed in the second gate region, the second nanowire set including a nanowire having a second diameter and connecting to a feature in the second source region and a feature in the second drain region. The diameters are such that if the first length is greater than the second length, the first diameter is less than the second diameter, and vice versa.
US08872159B2 Graphene on semiconductor detector
Ultraviolet or Extreme Ultraviolet and/or visible detector apparatus and fabrication processes are presented, in which the detector includes a thin graphene electrode structure disposed over a semiconductor surface to provide establish a potential in the semiconductor material surface and to collect photogenerated carriers, with a first contact providing a top side or bottom side connection for the semiconductor structure and a second contact for connection to the graphene layer.
US08872158B2 Semiconductor light emitting device
According to one embodiment, a semiconductor light emitting device includes an n-type semiconductor layer, a p-type semiconductor layer, and a light emitting part. The n-type semiconductor layer includes a nitride semiconductor. The p-type semiconductor layer includes a nitride semiconductor. The light emitting part is provided between the n-type and the p-type semiconductor layers and includes an n-side barrier layer and a first light emitting layer. The first light emitting layer includes a first barrier layer, a first well layer, and a first AIGaN layer. The first barrier layer is provided between the n-side barrier layer and the p-type semiconductor layer. The first well layer contacts the n-side barrier layer between the n-side and the first barrier layer. The first AIGaN layer is provided between the first well layer and the first barrier layer. A peak wavelength λp of light emitted from the light emitting part is longer than 515 nanometers.
US08872156B2 Group III nitride semiconductor light emitting device and method of fabricating group III nitride semiconductor light emitting device
A group III nitride semiconductor light emitting device includes an n-type cladding layer and a p-type cladding layer on a primary surface of a substrate, the c-axes of which tilt relative to the normal axis of the primary surface of the substrate. The p-type cladding layer is doped with a p-type dopant providing an acceptor level, and the p-type cladding layer contains an n-type impurity providing a donor level. An active layer is disposed between the n-type cladding layer and the p-type cladding layer. The concentration of the p-type dopant is greater than that of the n-type impurity. The difference (E(BAND)−E(DAP)) between the energy E(BAND) of a band-edge emission peak value in the photoluminescence spectrum of the p-type cladding layer and the energy E(DAP) of a donor-acceptor pair emission peak value in the photoluminescence spectrum is not more than 0.42 electron volts.
US08872153B2 Device structure for long endurance memristors
A memristor includes a first electrode formed of a first metal, a second electrode formed of a second material, wherein the second material comprises a different material from the first metal, and a switching layer positioned between the first electrode and the second electrode. The switching layer is formed of a composition of a first material comprising the first metal and a second nonmetal material, in which the switching layer is in direct contact with the first electrode and in which at least one conduction channel is configured to be formed in the switching layer from an interaction between the first metal and the second nonmetal material.
US08872152B2 IL-free MIM stack for clean RRAM devices
A nonvolatile memory device that contains a resistive switching memory element with improved device switching performance and lifetime, and methods of forming the same. A nonvolatile memory element includes a first electrode layer formed on a substrate, a resistive switching layer formed on the first electrode layer, and a second electrode layer. The resistive switching layer comprises a metal oxide and is disposed between the first electrode layer and the second electrode layer. The elemental metal selected for each of the first and second electrode layers is the same metal as selected to form the metal oxide resistive switching layer. The use of common metal materials within the memory element eliminates the growth of unwanted and incompatible native oxide interfacial layers that create undesirable circuit impedance.
US08872149B1 RRAM structure and process using composite spacer
A memory cell and method includes a first electrode formed in an opening in a first dielectric layer, the first dielectric layer being formed on a substrate including a metal layer, the opening being configured to allow physical contact between the first electrode and the metal layer, the first electrode having a first width W1 and extending a distance beyond a region defined by the opening, a resistive layer formed on the first electrode and having substantially the first width W1, a capping layer, having a second width W2 less than the first width W1, formed on the resistive layer, a second electrode formed on the capping layer and having substantially the second width W2, a first composite spacer region having at least two different dielectric layers formed on the resistive layer between the first width W1 and the second width W2, and a via coupled to the second electrode.
US08872148B2 Phase-change memory devices
A phase-change memory device includes a diode, a plug, a doping layer pattern, a phase-change layer pattern and an upper electrode. The diode is disposed on a substrate. The plug is disposed on the diode and has a bottom surface whose area is equal to the area of a top surface of the diode. The plug is formed of metal or a conductive metallic compound. The doping layer pattern is disposed on the plug and has a bottom surface whose area is equal to the area of a top surface of the plug, and includes the same metal or conductive metallic compound as the plug. The phase-change layer pattern is disposed on the doping layer pattern. The upper electrode is disposed on the phase-change layer pattern.
US08872141B2 Charged particle beam writing apparatus and charged particle beam writing method
A apparatus according to an embodiment includes a unit to generate first blocks in a writing region in which at least one of writing groups respectively using different base doses is to be written, a unit to generate second blocks for proximity effect correction, in the each of the regions of the groups, a unit to calculate an area density in each of the first blocks, a unit to perform a weighting calculation on the area density for each of the first blocks by using a base dose of a corresponding group, a unit to calculate a dose coefficient for proximity effect correction, for each of the second blocks, by using a corresponding weighted area density, and a unit to calculate a dose by using the base dose of the each of the groups and the dose coefficient of the each of the second blocks.
US08872134B2 Self indicating radiation alert dosimeter
Described is a self-indicating instant radiation dosimeter (1001) for monitoring high energy radiations, such as X-ray. The dosimeter contains a radiation sensitive, color changing, indicating composition (10), e.g., a diacetylene (R—C≡C—C≡C—R′, where R and R′ are substituents groups) or a radiochromic dye, a polymeric binder (20) and optionally a shelf life extender (50) or an activator (40). The radiation sensitive composition (10) changes color instantly when exposed to high energy radiation. The dose is estimated by comparing the color with a color reference chart or more accurately with a spectrophotometer or an optical densitometer. The radiation sensitive composition (10) is protected from low energy radiation such as UV light, by a layer of low energy absorbing materials, such as UV absorbers.
US08872133B2 Device for measuring the fluorescence of a medium
A device for measuring the fluorescence of a medium having a radiation source, an emission-receiving element and an optical imaging element arranged on the sensor side of the optical imaging element, and a scattering-receiving element arranged on the sensor side of the optical imaging element and in which the radiation source, the imaging element and the emission-receiving element are aligned and configured relative to one another so that the medium present on the medium side of the imaging element can be illuminated by radiation from the radiation source, and the emission intensity of the medium radiation emitted by the medium based on fluorescence can be detected with the emission-receiving element. To provide a device for measuring the fluorescence of a medium which has an increased reliability in measuring the fluorescence, temperature compensation is performed relative to the temperature of the medium and/or at least one of the receiving elements.
US08872132B2 System of fluorescence analysis of a field in an illuminated area
A system of analysis with the naked eye and by fluorescence of a field in an illuminated area comprising a periodically-excited first low-remanence white light illumination source; a second light source for exciting fluorescent elements located in said field, active at least during part of the time periods when the first source is off; and a fluorescence analysis device active during time periods when the first source is off and the second source is on.
US08872129B2 Microscopy support structures
Electron microscope support structures and methods of making and using same. The support structures are generally constructed using semiconductor materials and semiconductor manufacturing processes. The temperature of the support structure may be controlled and/or gases or liquids may be confined in the observation region for reactions and/or imaging.
US08872127B2 Beam current controller for laser ion source
The present invention relates to the design and use of an ion source with a rapid beam current controller for experimental and medicinal purposes. More particularly, the present invention relates to the design and use of a laser ion source with a magnetic field applied to confine a plasma flux caused by laser ablation.
US08872126B2 Target supply device and extreme ultraviolet light generation apparatus
A target supply device 4 may include a tank 51, formed of a metal, that holds a target material, an insulating member 62 that makes contact with at least part of the periphery of the tank 51, and a heater 58 that is separated from the tank 51 and heats the tank 51 via the insulating member 62.
US08872123B2 Method of timing laser beam pulses to regulate extreme ultraviolet light dosing
Described herein are embodiments of a method to control energy dose output from a laser-produced plasma extreme ultraviolet light system by adjusting timing of fired laser beam pulses. During stroboscopic firing, pulses are timed to lase droplets until a dose target of EUV has been achieved. Once accumulated EUV reaches the dose target, pulses are timed so as to not lase droplets during the remainder of the packet, and thereby prevent additional EUV light generation during those portions of the packet. In a continuous burst mode, pulses are timed to irradiate droplets until accumulated burst error meets or exceeds a threshold burst error. If accumulated burst error meets or exceeds the threshold burst error, a next pulse is timed to not irradiate a next droplet. Thus, the embodiments described herein manipulate pulse timing to obtain a constant desired dose target that can more precisely match downstream dosing requirements.
US08872122B2 Method of timing laser beam pulses to regulate extreme ultraviolet light dosing
Described herein are embodiments of a method to control energy dose output from a laser-produced plasma extreme ultraviolet light system by adjusting timing of fired laser beam pulses. During stroboscopic firing, pulses are timed to lase droplets until a dose target of EUV has been achieved. Once accumulated EUV reaches the dose target, pulses are timed so as to not lase droplets during the remainder of the packet, and thereby prevent additional EUV light generation during those portions of the packet. In a continuous burst mode, pulses are timed to irradiate droplets until accumulated burst error meets or exceeds a threshold burst error. If accumulated burst error meets or exceeds the threshold burst error, a next pulse is timed to not irradiate a next droplet. Thus, the embodiments described herein manipulate pulse timing to obtain a constant desired dose target that can more precisely match downstream dosing requirements.
US08872121B2 Radiation imaging apparatus
A radiation imaging apparatus includes: a first cooling fan configured to cool a first heat generation portion of a radiation detection unit housed in the radiation imaging apparatus, by blowing a cooling medium to the first heat generation portion; a second cooling fan configured to cool a second heat generation portion of the radiation detection unit housed in the radiation imaging apparatus, which is larger in amount of generated heat than the first heat generation portion, by blowing the cooling medium to the second heat generation portion; and a discharge port formed in a position nearer to the second heat generation portion than to the first heat generation portion and configured to discharge the cooling medium which received heat from the first heat generation portion and the cooling medium which received heat from the second heat generation portion.
US08872115B2 Radiological image conversion panel, method of manufacturing the same, and radiological image detection apparatus
A radiological image conversion panel 2 provided with a support 11 and a phosphor 18 which is formed on the support and contains a fluorescent material that emits fluorescence by radiation exposure. The phosphor includes a columnar section 34 formed by a group of columnar crystals which are obtained through columnar growth of crystals of the fluorescent material, and a non-columnar section 36. The columnar section and the non-columnar section are integrally formed to overlap in a crystal growth direction of the columnar crystals, and a porosity at the columnar section side of the non-columnar section is higher than a porosity at the support side of the non-columnar section.
US08872114B2 Inspection apparatus and inspection method
A technology of inspecting a photoexcited carrier generation area of a photo device in a non-contact manner is provided. An inspection apparatus inspects a photovoltaic cell panel in which the photo device is formed. The inspection apparatus includes an irradiation part that irradiates the photovoltaic cell panel with pulsed light from a light receiving surface side and a detecting part (detector) that detects electric field intensity of a terahertz wave pulse, which is generated according to the irradiation of the pulsed light.
US08872113B2 System to test performance of pixels in a sensor array
A system to test operation of an optical sensor is disclosed. The optical sensor includes one or more photosensitive devices configured to convert light to electrical signals. A test light source and a reference target are included within the housing of the optical sensor. The test light source is mounted proximate to the photosensitive devices and the reference target is positioned opposite from the test light source. The test light source is periodically pulsed on to emit light at a known wavelength. The light is reflected from the reference target back to at least a portion of the photosensitive devices. A logic circuit uses the reflected light which is received at the portion of the photosensitive devices to determine the distance between the light source and the reference target. This calculated distance is compared against the known distance to verify correct operation of the optical sensor.
US08872112B2 Hybrid THz imaging detector with vertical antenna and sub-pixel suspended MEMS thermal sensor and actuator
A THz radiation detector comprising a vertical antenna separated from a suspended platform by an isolating thermal air gap for concentrating THz radiation energy into a smaller suspended MEMS platform upon which a thermal sensor element is located. THz photon energy is converted into electrical energy via a thermally isolated air gap between plates of a coupling capacitor that couples energy from the antenna to the thermal sensor. The capacitor plates used for capacitive coupling of the received signal realize an electro-static actuator whereby the application of a DC bias varies the coupling capacitor gap. The DC bias causes the actuator to pull the suspended platform close to the antenna to reduce the capacitive gap, increasing the coupling capacitance, to touch the antenna array thus quickly discharging the heat induced in the sensor platform or to perform advanced readout operations, such as amplitude modulation and correlated double sampling.
US08872111B2 Infrared spatial modulator for scene-based non-uniformity image correction and systems and methods related thereto
Embodiments of an infrared spectral modulator for scene-based non-uniformity image correction are generally disclosed herein. The spectral modulator may be suitable for use in a system for navigating an object having a flight path comprising an infrared sensor having an optical path; an infrared modulator in the optical path of the infrared sensor, wherein the infrared modulator is configured to allow the infrared sensor to perform in situ, real-time, scene-based non-uniformity correction; and a guidance system within the object, wherein the guidance system can adjust the flight path of the object based on the non-uniformity correction.
US08872108B2 Radiation monitoring apparatus
In a radiation monitoring apparatus having a radiation monitor composed of a radiation detector and a measurement section, and a testing apparatus, an accumulated value setting circuit which forcibly sets an accumulated value of an up-down counter of the measurement section is provided, whereby in a test mode, a test is conducted after the accumulated value of the up-down counter is set at a value corresponding to a start count rate by the accumulated value setting circuit.
US08872102B2 Ion mobility spectrometer and method of operating same
An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field activation sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of electric field activation sources in a manner that sequentially applies electric fields to the drift tube segments with a activation duration of at least one of the electric field activation sources different than that of the others to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path.
US08872101B2 Electrooptic module and electronic device having a cover partitioning a first ventilation path which extends along an extending direction of the first side end surface of a translucent plate
A small-sized first translucent plate overlapped on an image display region and a plate-like cover are provided on a first substrate. Engagement plate portions of the plate-like cover are engaged with a frame so that the plate-like cover is bonded to the frame. The plate-like cover constitutes a ventilation path which extends along an extending direction of a side end surface of the first substrate and is opened at both sides of the extending direction together with a side end surface of the first translucent plate, an exposed portion of an electrooptic panel from the first translucent plate, and the frame.
US08872098B2 Scanning FTIR systems for touch detection
A touch-sensitive apparatus operates by FTIR (Frustrated Total Internal Reflection) to detect touches on a surface of a light transmissive panel. An illumination arrangement is controlled to propagate light by internal reflection from an elongated incoupling site on the panel to an elongated outcoupling site on the panel, and a detection arrangement is controlled to detect light reaching the outcoupling site. The illumination arrangement is controlled to sweep a first set of individual beams of light along different subsets of the incoupling site to generate a full beam sweep along the incoupling site. Thereby, the individual beams are be controlled to generate a “sub-sweep” of the incoupling site, which enables a compact design of the illumination arrangement and/or use of comparatively simple sweep generating devices and/or identical re-direction components in the illumination arrangement.
US08872096B2 Method and apparatus for detecting failures of a dual matrix sensor array
The subject matter disclosed herein describes an optical sensor used in a safety system. The sensor includes two pixel matrices on a single substrate. Each of the pixel matrices are arranged in a row and column format, and pixels from one matrix are interspersed with pixels from the other matrix such that alternating pixels in each row and column belong to separate matrices. Two sets of selection logic allow each matrix to be enabled separately. Additional monitoring logic is included to detect shorted pixels and/or shorted selection lines. In addition, the frames generated by each pixel array may be compared to detect variation in performance between arrays.
US08872093B2 Calibrated image-sensor-based ambient light sensor
An electronic device may be provided with an image sensor for capturing digital images. The image sensor may be used as part of image-sensor-based ambient light sensing circuitry for producing ambient light sensor readings. The image-sensor-based ambient light sensing circuitry may include a reference array. The reference array may be formed from an array of light sensor elements that are matched to elements in the image sensor but that are covered with a light blocking material. Control circuitry can measure current flow into the reference array and the image sensor array and can use current measurements from these arrays in producing a calibrated ambient light sensor reading. The control circuitry may make current measurements by measuring a decay time associated with the voltage of a discharging capacitor. A comparator, pulse generator, and switch may be used in periodically recharging the capacitor. The capacitor may be adjusted to ensure accurate readings.
US08872092B2 Photo-electric conversion device with current fluctuation suppression
A photo-electric conversion device comprises a pixel array in which a plurality of pixels, each including a photo-electric converter, are arrayed to form rows and columns; signal lines respectively corresponding to the columns of the pixel array; load transistors respectively corresponding to the signal lines; and capacitances respectively corresponding to the load transistors. Each signal line is connected to the pixels of the corresponding column. Each capacitance includes a first electrode and a second electrode. When viewed from a direction perpendicular to a light-receiving surface of the photo-electric converter, the first electrode is arranged within a region which is surrounded by (i) the adjacent signal lines which are arranged closest to each other, (ii) the pixel array, and (iii) a virtual line connecting end portions of the adjacent signal lines, so as to not overlap the adjacent signal lines.
US08872090B2 Solid-state imaging device having floating diffusion units disposed at greater intervals than adjacent ones of horizontal transfer units
A solid-state imaging device includes: a plurality of photoelectric conversion units arranged in rows and columns in a pixel region; a plurality of vertical transfer units arranged for corresponding columns of the photoelectric conversion units, and transfer, in a column direction, the signal charges read from the corresponding columns of the photoelectric conversion units; a first and a second horizontal transfer units arranged in parallel, and transfer, in a row direction, the signal charges transferred by the vertical transfer units; and a first and a second output units which (i) include floating diffusion units each formed in a region adjacent to an output end of a corresponding one of the first and the second horizontal transfer units and (ii) output, as electric signals, the transferred signal charges, wherein the floating diffusion units are disposed at greater intervals than adjacent ones of the horizontal transfer units.
US08872082B2 Flying object having one body wings
Disclosed is a flying object in which a covering unit and a wing unit installed in a nozzle assembly are integrally formed to form a smooth outer surface of the flying object, thus minimizing drag, and the covering unit and the nozzle assembly are fastened by using a fastening member having one end fastened to a slit, thereby preventing the flying object from being damaged by thermal deformation.
US08872079B2 Apparatus for preparing a food item in a microwave oven
An apparatus for preparing a food item in a microwave oven comprises a tray including a plurality of elevated heating areas and a plurality of channels disposed between the elevated heating areas, the elevated heating areas each including a microwave energy interactive material, a cover pivotably connected to the tray for pivoting the cover relative to the tray between an open position and a closed position, and a locking feature operative for releasably maintaining the cover in the closed position.
US08872078B2 Microwave heating construct
Various blanks are provided for forming sleeves, containers, and other constructs for heating, browning, and/or crisping of a food item in a microwave oven, and for holding and/or transporting the food item after heating. The various blanks, sleeves, containers, and other constructs may include a removable portion defined by one or more lines of disruption that enable the removable portion to be separated from the remainder of the blank, sleeve, container, or other construct.
US08872073B2 Image forming apparatus
An image forming apparatus includes a heat source of a fixing device to heat when an alternate current signal is supplied thereto; a conduction control circuit for controlling an alternate current power source with a conduction control signal, and for supplying the alternate current signal to the heat source; and a control unit for outputting the conduction control signal in a specific pattern. The conduction control circuit includes a conduction control element for switching between conduction and non-conduction at a zero cross timing of the alternate current power source according to the conduction control signal, and for supplying the alternate current signal.
US08872070B2 Offline teaching method
A three-dimensional rectangular coordinate system is set in which the direction of a weld line is the Y direction, a direction perpendicular to a surface of a material to be welded is the Z direction, and a direction perpendicular to the Y direction and the Z direction is the X direction. A coordinate system A of XAYAZA is set as a previous stage coordinate system, which ranges from a previous step to a current step, and a coordinate system B of XBYBZB is set as a next stage coordinate system, which ranges from the current step to a next step. The weld line is defined by these coordinate systems that use a workpiece as a reference, and an operator specifies the amount of travel of a torch in these workpiece coordinate systems. By this method, offline teaching can be accurately performed in a welding system without requiring skill in operation.
US08872067B2 Laser beam working machine
A cylindrical lens (4) diverges a laser beam (L1) in the Y-axis direction (i.e., within the YZ plane) but neither diverges nor converges it in the X-axis direction (i.e., within the ZX plane). An objective lens (5) converges the laser beam (L1) emitted from the cylindrical lens (4) into a point P1 in the Y-axis direction and into a point P2 in the X-axis direction. A pair of knife edges (13) adjust the divergence angle (θ) of the laser beam (L1) incident on the objective lens (5) in the Y-axis direction. As a consequence, the cross section of the laser beam (L1) becomes an elongated form extending in the Y-axis direction at the point P2, while the maximum length in the Y-axis direction is regulated. Therefore, locating the point P2 on the front face of a work (S) can form an elongated working area extending in the Y-axis direction by a desirable length on the front face of the work (S).
US08872066B2 Method for perforating material
A method of drilling holes through a solid material in such manner as to give holes in a first area a first profile and distribution and holes in a second area a second profile and distribution comprising the steps of: —defining a first area in which holes have a first profile and distribution; —defining a second area in which holes have a second profile and distribution at least one of which is different from that in the first area; —defining a transition zone in which holes have a profile and/or distribution as the case may be which undergo a continuous and gradual transition from that in the first area to that in the second area; —drilling holes in all of the first area, the transition zone and the second area via a continuous process.
US08872061B2 Apparatus for disconnecting solder joints between two welded surfaces
An apparatus for disconnecting solder joints between two welded surfaces includes a laser device for emitting laser beams to a solder joint, and a solder material removal device. And the solder material removal device includes a nozzle device having a first passage, a holder holding the nozzle device and having a second passage communicated with the first passage, and at least two pumping devices connected to the holder to pump the melted solder material out from the nozzle device and the holder. The laser device and the solder material removal device are separated, a glass cover with a hole formed thereon is covered on the top of the holder, and the laser device is located above the glass cover and separated from the holder. The present invention can shorten maintenance time and maintenance workload and improve work efficiency, furthermore reduce and stabilize the laser energy.
US08872052B2 Jumper with integrated switch
This novel jumper features an integrated mechanical switch that allows resetting the CMOS memory of computer motherboards just by actuating a reset button on the jumper, instead of moving a prior-art jumper back and forth over the CMOS-reset block. The disclosed jumper can also be adapted for use as temporary button for powering on, restarting and resetting motherboards when tested alone; in this case the jumper just needs to be inserted over the corresponding pair of pins on the front-panel header of the motherboard. This jumper is also applicable to other electric or electronic devices where operating the jumper's integrated switch is more convenient or safer than moving prior-art jumpers or manually shorting up pins on printed circuit boards.
US08872051B2 Control device for switches with silicone domes
A control device for switches with silicone domes comprising actuator means (10) which act on silicone domes (13) associated with metallic means adapted to close and selectively open electric contacts of a printed circuit activators characterized in that between each actuator means (10) and the respective silicone dome (13) a metallic plate (11) is positioned which rests one side on the dome (13) and the other on the printed circuit (15) and upon which said actuator means act.
US08872050B2 Circuit-breaker, in particular for low voltages
A circuit breaker is disclosed, in particular for low voltages, having a switch shaft and a contact lever rotationally mounted and extending transverse to the longitudinal axis of the switch shaft and protruding out of the switch shaft, the shaft carrying a movable contact on a side of the outer contour of the contact piece, and including a recess on the opposite side of the outer contour thereof for suspending a pin having a force applied thereto on both sides of the contact lever by way of one spring each, each applying a torque to the contact lever in the closing direction. The two springs each include a cover element extending along the spring and each disposed between the spring and the arc formed between the contact pieces when the circuit breaker is opened.
US08872043B2 Electric connection device and a method of producing such a device
A device for electric connection to an energy supply conductor for intermediate and high voltage. The device includes an insulation part and an electrically conducting voltage-carrying part. The voltage-carrying part is surrounded by an outer shell formed by the insulation part. The insulation part is formed by a thermoplastic polymer. At least along a part of the length of the voltage-carrying part, the outer shell extends with a spacing between its inner periphery and the outer periphery of the voltage-carrying part.
US08872042B2 Methods and systems for providing inflatable lightweight shielded enclosures
An inflatable, lightweight shielded enclosure that includes one or more inflatable, lightweight shielded beams arranged to support a shielded material, and an inflatable, lightweight shielded connection system for connection to a control system is provided along with related methods. The enclosure may have a weight of approximately twenty-one pounds, and provide an attenuation of 70 dB to 80 dB for a 1 GHz signal.
US08872039B2 Conductive element and method for producing the same, wiring element, information input device, display device, electronic apparatus, and master
A conductive element includes a base having a first wavy surface, a second wavy surface, and a third wavy surface, a first layer provided on the first wavy surface, and a second layer provided on the second wavy surface. The first layer has a multilayer structure including two or more stacked sublayers, the second layer has a single-layer or multilayer structure including part of the sublayers constituting the first layer, and the first and second layers form a conductive pattern portion. The first, second, and third wavy surfaces satisfy the following relationship: 0≦(Am1/λm1)<(Am2/λm2)<(Am3/λm3)≦1.8 (Am1: mean amplitude of first wavy surface, Am2: mean amplitude of second wavy surface, Am3: mean amplitude of third wavy surface, λm1: mean wavelength of first wavy surface, λm2: mean wavelength of second wavy surface, λm3: mean wavelength of third wavy surface).
US08872036B2 Suspension board with circuit and producing method thereof
A suspension board with circuit includes a metal supporting board, an insulating base layer formed on the metal supporting board, a conductive pattern formed on the insulating base layer, an insulating cover layer formed on the insulating base layer so as to cover the conductive pattern, and an insertion portion to be inserted into an E-block. A thickness of the insulating cover layer in the insertion portion is larger than a thickness of the insulating cover layer in a portion other than the insertion portion.
US08872034B2 Flame retardant thermoplastic composition
Flame retardant thermoplastic composition comprising at least one thermoplastic polymer, preferably a thermoplastic polyurethane polymer, at least one conventional flame retardant and optionally at least one mineral filler together with modified polysiloxane in an amount of less than 1% by weight based on the total composition, preferably between 0.1 and 0.9% and most preferably between 0.25 and 0.75% by weight. The thermoplastic compositions are useful in applications where low flame properties are desirable, such as wire and cable applications.
US08872029B2 Self-opening innerduct for a conduit
An innerduct (10) for insertion into a conduit includes at least one cell (11) which forms a compartment (14). A self opening stiffener (15) includes branches (16) attached at their ends (17). When the innerduct (10) is on a roll, the branches (16) are positioned adjacent to each other. When the innerduct (10) is being inserted into the conduit, the branches (16) move away from each other to open the compartment.
US08872025B2 Waterproof structure of electronic unit
A waterproof structure of an electronic unit includes a case that defines a housing portion housing a first terminal, and a connector that includes an insulating body attached to the case. The connector includes a second terminal that is supported by the insulating body and connects a conductor end portion of a cable to the first terminal. The insulating body includes a wall portion that partitions a part of the housing portion by covering an open portion of the case. The insulating body includes a cable lead-in portion that defines a cable lead-in hole for leading the cable into the case and is joined to the wall portion. A potting resin is filled in a space between the inner periphery of the cable lead-in hole and the outer periphery of the cable and the housing portion and cured.
US08872023B2 Multi-modal electronic device cover
A cover for an electronic device includes first and second planar members wherein, a first end of the second planar member is disposed adjacent to a first end of the first planar member. The cover also includes a coupling arrangement configured to be attached to a first end of the electronic device and configured to permit rotation of the first and second planar members around the first end of the electronic device, and a rotational hinge configured to couple together the first ends of the first and second planar members such that the second planar member is rotatable with respect to the first planar member.
US08872016B2 Thermoelectric conversion structure and method of manufacturing same
A thermoelectric conversion material in a wire structure or quasi-one-dimensional structure is fabricated simply and with good reproducibility. In one mode of the present invention, a thermoelectric conversion structure 100 is provided, having a SrTiO3 substrate 10 having a (210) plane substrate surface and having a concave-convex structure including (100) plane terrace portions 12, 14 and step portions 16 extending along the in-plane [001] axis of the substrate surface, and a thermoelectric conversion material 22 formed on the surface of at least a portion of the concave-convex structure.
US08872015B2 Cymbal transducer using electret accelerometer
In one embodiment, a cymbal system includes a cymbal and a transducer couplable to the cymbal. The transducer has a sound pressure microphone, and a casing hermetically sealing the sound pressure microphone to prevent communication of air pressure differentials into the sound pressure microphone. The cymbal may be a perforated low volume cymbal. In one embodiment, a method for making a cymbal transducer includes sealing a sound pressure microphone in an airtight enclosure, and configuring the sealed sound pressure microphone for attachment to a cymbal.
US08872014B2 Multi-media spatial controller having proximity controls and sensors
A controller having proximity sensors associated with a trigger, such as beam sensors, configured to generate proximity data as a function of where each beam is broken along its span. A variety of control signals are be generated, whereby each beam can be configured to be spatially controlled and mapped to mimic other controllers, such as those of a DJ controller or other entertainment device. MIDI messages may be generated in response to positioning a member in a beam as detected by the proximity sensors. Each beam may be configured into a plurality of proximity zones, where a different MIDI message is generated when the member is positioned in the respective proximity zone.
US08872013B2 Audiovisual teaching apparatus
The audiovisual teaching apparatus (2) for demonstration purposes before a group of students has a frame (6) on which is mounted a board (4). The front surface of the board (4) includes an area (5) treated to function as a whiteboard surface on which standard dry-maker pens can be used to removably write and draw on the surface. The whiteboard surface (5) is pre-printed with a plurality of musical staves (8) and has an array of substantially parallel conductive tracks aligned with the lines and spaces of the musical staves (8). The conductive tracks are connected to sound reproduction apparatus and a hand-held wand (24), which includes a localized antenna, is adapted to select an individual line or space of the musical stave (8) so that the selected note is played by the sound reproduction apparatus.
US08872012B2 Music pre-end-play processing method using time data and electronic apparatus for implementing the same
A music data processing method applied to an electronic apparatus includes obtaining a time data; retrieving a partial music data from an input music data according to the time data; and performing a pre-end-play processing on the partial music data to output an output music data. With the pre-end-play processing performed, the output music data is substantially different from the partial music data.
US08872011B2 Visual, tactile and motion-sensation system for representing music for an audience
System of translation between written or performed music and visual, tactile and motion sensation experiences. Specific metaphors for most aspects of music among these non-audio media are described. Examples include rules for color assignment to pitches in a scale; positioning visual representations of notes; visualizing notes between pitches; arranging tactile stimuli to represent pitches; and rendering stages of cadence with motion sensing experiences such as movement within space, or changes in one's tilt, pitch, etc. The system includes documentation of theoretical/interpretive elements such as key signature, current chord, association of notes with melody, as they occur in a piece, along with metaphors for their translation in these non-audible media. The metaphors are strictly prescribed, yet accommodating large variations and freedoms in visual, tactile and motion renderings by producers/artists, allowing for visual, tactile or motor metaphors for non-musical instrument sounds such as finger sliding across windings of a guitar string.
US08872009B2 Sound post inserting / removing tool
Violin Sound Post inserting tool with a handle having a spring type clamp attached at right angle. One half of the clamp has a groove or cradle into which sound post is placed. The second half is a spring plate which secures the Sound Post in the clamp. After the sound post has been introduced and firmly set inside the violin sound box the spring plate of the clamp can be deflected by pressure against the sound post, thus opening the clamp. Also the spring plate has extended lip beyond the cradle, thus with the clamp open the sprig part is made to slide along the sound post without interference from the cradle of the base plate.
US08872004B2 Soybean cultivar S110126
A soybean cultivar designated S110126 is disclosed. The invention relates to the seeds of soybean cultivar S110126, to the plants of soybean cultivar S110126, to the plant parts of soybean cultivar S110126, and to methods for producing progeny of soybean cultivar S110126. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S110126. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S110126, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S110126 with another soybean cultivar.
US08872003B2 Resistance to post harvest deterioration in cucumber
The invention relates to a cucumber (Cucumis sativus) plant, which has the improved shelf life as found in plants and fruits grown from seeds of cucumber EX5001 representative seeds of which were deposited under NCIMB accession number 41670. The plant may be obtainable by crossing a cucumber plant with a plant grown from seeds of cucumber EX5001 representative seeds of which were deposited under NCIMB accession number 41670 and selecting in the F2 progeny of the cross that may be obtained after selfing the F1 for plants showing an improved shelf life.
US08872002B1 Canola line NS6163
A novel canola variety designated NS6163 and seed, plants and plant parts thereof. Methods for producing a canola plant that comprise crossing canola variety NS6163 with another canola plant. Methods for producing a canola plant containing in its genetic material one or more traits introgressed into NS6163 through backcross conversion and/or transformation, and to the canola seed, plant and plant part produced thereby. Hybrid canola seed, plant or plant part produced by crossing the canola variety NS6163 or a locus conversion of NS6163 with another canola variety.
US08872001B2 Compositions and methods for insecticidal control of stinkbugs
Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
US08871994B2 Wetness sensor for use in an absorbent article
A wetness sensor for an absorbent article that is formed from an ink is provided. The ink includes a proton-accepting chromogen and a proton-donating agent (or color developer). Prior to use, the ink is generally dry and in a protonated form so that it has a visible color. However, upon contact with bodily fluids (e.g., urine, fecal matter, mucus, menses, vaginal fluid, etc.), water in the fluid can lead to deprotonation of the chromogen, thereby resulting in a shift of the absorption maxima of the chromogen towards either the red (“bathochromic shift”) or blue end of the spectrum (“hypsochromic shift”). To increase the rate of the color change during use, the proton-donating agent is an aliphatic carboxylic acid that is highly soluble in the bodily fluid (e.g., urine), and therefore results in a color change that is very rapid and may be detected within a relatively short period of time.
US08871993B2 Permeable pressure sensitive adhesive
The present invention relates to a pressure sensitive adhesive composition for skin application. The adhesive composition comprises 10-50% (w/w) based on the total adhesive composition of a polar part; 10-50% (w/w) based on the total adhesive composition of an apolar part; and 0-60% (w/w) based on the total adhesive composition of hydrocolloid.
US08871992B2 Multilayer compositions and dressings
The invention provides a layered composition comprising: a first layer comprising a first material, wherein the first material comprises a gel material; a second layer comprising a second material, wherein the second material is harder is than the first material; and a third layer comprising a third material, wherein the third material has a lower tensile modulus than the second material, wherein the second layer is disposed between the first and third layers. The composition may be used in a wound dressing, in which preferably the first layer is in fluid flow communication with the wound.
US08871986B2 Catalyst promoters for producing trifluoroiodomethane and pentafluoroiodoethane
The present invention provides a process for the preparation of a fluoroiodoalkane compound represented by the formula CF3(CF2)n—I, wherein n is 0 or 1. The process includes the step of contacting: (i) a compound represented by the formula CF3(CF2)n—Y, wherein Y is selected from H, Cl, Br, and COOH and n is 0 or 1; (ii) a source of iodine; (iii) an alkali or alkaline earth metal salt catalyst supported on a carrier; and (iv) a catalyst promoter for the alkali or alkaline earth metal salt catalyst. The catalyst promoter includes at least one element selected from a transition metal element, a rare earth metal element, a main group element other than the alkali or alkaline earth metal element, any salts thereof, and any combinations thereof. The contacting is carried out at a temperature and pressure and for a length of time sufficient to produce the fluoroiodoalkane compound. The contacting may be carried out in the presence or absence of a solvent and in the presence or absence of oxygen.
US08871982B2 Hydrogenation of dienals with rhodium complexes under carbon monoxide free atmosphere
The present invention relates to the field of catalytic hydrogenation and, more particularly, to a process for the reduction by hydrogenation, using molecular H2, of a C6-C20 conjugated dienal into the corresponding deconjugated enal, characterized in that said process is carried out in the presence of a catalytic system comprising at least a base and at least one complex in the form of a rhodium complex comprising a C34-C60 bidentate diphosphine ligand (L2) coordinating the rhodium.
US08871980B2 Process for producing hydrogen or heavy hydrogens, and hydrogenation (protiation, deuteration or tritiation) of organic compounds using same
An object is to provide a process for providing hydrogen or heavy hydrogens conveniently without the necessity of large-scale equipment and a process capable of performing hydrogenation (protiation, deuteration or tritiation) reaction conveniently without the use of an expensive reagent and a special catalyst. The production process includes a process for producing hydrogen or heavy hydrogens, containing subjecting water or heavy water to mechanochemical reaction in the presence of a catalyst metal, and a process for producing a hydrogenated (protiated, deuterated or tritiated) organic compound, containing subjecting an organic compound and water or heavy water to mechanochemical reaction in the presence of a catalyst metal.
US08871975B2 Process for the synthesis of agomelatine
Process for the industrial synthesis of the compound of formula (I)
US08871974B2 Ionic liquid containing phosphonium cation having P—N bond and method for producing same
An ionic liquid which contains an organic matter represented by the following general formula (1) as a cation component. The ionic liquid is stably in a liquid state over a wide temperature range and is excellent in electrochemical stability. The ionic liquid is advantageously used for applications such as electric power storage devices, lithium secondary batteries, electrical double layer capacitors, dye-sensitized solar cells, fuel cells, and reaction solvents.
US08871972B2 Process for the preparation of adapalene and related compounds
The invention provides an improved process for the preparation of a benzonaphthalene derivative including, in particular, the manufacture of high purity adapalene. The invention further includes a method for assessing the color of adapalene by means of a quantitative colorimetric measurement of the produced adapalene.
US08871969B2 Process for the production of polyisocyanates
The invention provides a multistage process for continuously preparing organic polyisocyanates, preferably diisocyanates, more preferably aliphatic or cycloaliphatic diisocyanates, by reaction of the corresponding organic polyamines with carbonic acid derivatives and alcohols into monomeric polyurethanes of low molecular mass, and the dissociation of said polyurethanes. The invention further provides an associated preparation process in which at certain reaction stages the polyisocyanates prepared and unutilizable residues are removed and reusable by-products and intermediates are recycled to preliminary stages.
US08871965B2 Method for producing urethanes
The content of the invention is a process for preparing urethanes by reaction of aromatic amines with a dialkyl carbonate, wherein the alkyl radical of the organic dialkyl carbonate comprises 4-18 carbon atoms and is branched in the 2 position, and the reaction is performed in the presence of a substoichiometric amount of base, based on the amino groups.
US08871962B2 Method for producing sanshool
Provided are a method for producing a sanshool, which method has a short process and exhibits high stereoselectivity, as well as an iron carbonyl complex compound that is an intermediate useful for the production method.A diene iron complex compound characterized by being represented by the following general formula (I): (in which A represents CO, P(RA)3, CN, NO, SO(RA)3, or N(RA)2; RA represents a straight chain or branched chain alkyl group having 1 to 4 carbon atoms or an aryl group having 6 to 12 carbon atoms; and one of R1 and R2 represents a hydrogen atom and the other one thereof represents a structure represented by the following formula (II)): (in which R represents a hydrogen atom, a hydroxyl group, or a methyl group).
US08871958B2 Method for preparing 5-chloromethyl-2-furfural using galactan derived from seaweed in two component phase
The present disclosure relates to an acid catalyst composition for producing 5-chloromethyl-2-furfural from galactan derived from seaweed and a method for producing 5-chloromethyl-2-furfural from galactan derived from seaweed on a two component phase using the acid catalyst, the acid catalyst composition for producing 5-chloromethyl-2-furfural from galactan derived from seaweed including organic solvent and dilute hydrochloric acid, a concentration of the dilute hydrochloric acid being 4N to 8N (normal).According to the present disclosure, there is an advantage of converting 5-chloromethyl-2-furfural from galactan derived from seaweed by means of a single process by mixing dilute hydrochloric acid and organic solvent by an optimal ratio, unlike conventional methods for producing 5-chloromethyl-2-furfural that had to go through a multi-phase process of preconditioning and saccharification.
US08871957B2 Metal catalyst composition for producing furfural derivatives from raw materials of lignocellulosic biomass, and method for producing furfural derivatives using the composition
The present invention relates to a metal catalyst composition for producing furfural derivatives from raw materials of lignocellulosic biomass, and method for producing furfural derivatives using the composition. The present invention comprises ruthenium chloride (RuCl3) and chromium chloride (CrCl2). The chromium chloride (CCl2) is from 300 to 500 parts by weight on the basis of 100 parts by weight of the ruthenium chloride (RuCl3). Unlike conventional furfural derivatives producing process that should go through multi step processes such as pre-process, saccharification process, etc, the present invention has an advantage of producing furfural derivatives from lignocellulosic raw material only through simple reaction process in one reaction apparatus by mixing various kinds of metal catalyst at an optimum ratio.
US08871955B2 Process for the purification of pharmaceutically acceptable salts
The present invention is concerned with a process in connection with the purification of a pharmaceutically acceptable salt of escitalopram or citalopram.
US08871950B1 Process for preparing (+)-polyoxamic acid
The present invention relates to a method for preparing (+)-polyoxamic acid and a novel intermediate compound synthesized during preparation thereof.The preparation method according to the present invention allows preparation of (+)-polyoxamic acid with high optical purity in high yield. In particular, the preparation method is useful for mass production because the process is simple.
US08871947B2 Preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester
The present disclosure provides a novel and economically advantageous process for preparation of compounds of Formula I, such as alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester. The process includes acidification of the sodium enolate of alkyl difluoroacetoacetate by carbonic acid generated in situ by reacting carbon dioxide with water. The disclosure also includes promoting the ring closure reaction in which alkyl 2-alkomethylene-4,4-difluoro-3-oxobutyrate is reacted with methylhydrazine in two phase system with a weak base such as Na2CO3 or K2CO3.
US08871946B2 Benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses
The present invention relates to the benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses; wherein X represents monosubstituted or bissubstituted or polysubstitued C1-C14 alkoxy, monosubstituted or bisubstituted or polysubstitued C1-C14 alkyl, monosubstituted or bisubstituted or polysubstitued C2-C14 alkenyl, monosubstituted or bisubstituted or polysubstitued C6-C14 aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom; Y represents hydrogen, monosubstituted or bisubstituted or polysubstitued C1-C16 alkyl, monosubstituted or bisubstituted or polysubstitued C6-C12 aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom. The derivatives of the present invention have the functions of antiviral medicine.
US08871944B2 Thiazole derivative and process for producing same
An object is to provide a thiazole derivative produced from easily available raw materials by a simplified production process. Provided are a process for producing a novel thiazole derivative represented by the general formula (I), which is characterized by adding a strong base to a thioamide represented by the general formula (II) and reacting the mixture with a thioformamide represented by the general formula (III), and a novel thiazole derivative.
US08871942B2 Process for producing 1-triazole-2-butanol derivatives
An object is to provide a process for producing the compound of formula 1 in higher yield by the ring-opening addition reaction of epoxytriazole with amine under mild conditions without using a large excess of 4-methylenepiperidine. The process for producing (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol or an acid addition salt thereof comprises reacting (2R,3S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane with an acid addition salt of 4-methylenepiperidine in a reaction solvent in the presence of a hydroxide of an alkali metal or an alkaline earth metal selected from the group consisting of lithium, sodium, calcium, and strontium, or a hydrate thereof.
US08871939B2 Method for preparing 2-aminobenzamide derivatives
A method for preparing a compound of Formula 1 comprising contacting a compound of Formulae 2 and 3 in the presence of a palladium source, a ligand, a base and carbon monoxide wherein R1, R2, X and R3 are as defined in the disclosure. A method for preparing a compound of Formula 5 wherein R1, R2, R3, R4, R5, R6 and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing a compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method above.
US08871937B2 8-hydroxy-quinoline derivatives
The invention relates to compounds of the general formula (I) and their pharmaceutically acceptable salts (in which formula R1 represents a hydrogen atom, lower alkyl group, lower alkenyl group, lower cycloalkyl group, aryl group, aralkyl group or heterocyclic group, wherein, the above groups are optionally substituted in ortho, meta and/or para position with 1, 2, 3 or 4 electron withdrawing groups or electron donating groups; R2 represents a hydrogen atom, lower alkyl group, aryl group, aralkyl group or heterocyclic group wherein the above groups are optionally substituted with one or more halogen atoms; R3 represents a lower alkyl group, aryl group, aralkyl group or heterocyclic group wherein the above groups are optionally substituted in ortho, meta or para position with 1, 2, 3 or 4 electron withdrawing groups or electron donating groups; R4 represents a hydrogen atom, lower alkyl group or any acidic functional group; n is 1 or 2). The compounds according to the invention can be used in the medicine mainly for the treatment of diseases associated with neurological and/or oxidative stress.
US08871936B2 Method for manufacturing of quinoline-3-carboxamides
A method for preparing a compound of formula (I) by reacting the appropriate alkyl ester and an aniline derivative, in a refluxing mixture containing an aliphatic solvent or a mixture of aliphatic solvents having a boiling point in the range of 68-191° C.; condensing vapors of the refluxing mixture; treating the condensed vapors with an alcohol scavenging agent or a mixture of alcohol scavenging agents; and returning the condensed vapors back to the reaction mixture.
US08871934B2 Fluorene compound and pharmaceutical use thereof
The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.
US08871932B2 Process for the preparation of tadalafil
The present invention relates to a process for the preparation of tadalafil of Formula I, comprising reacting a D-tryptophan compound of Formula III with piperonal in sulfolane.
US08871931B2 Di-O-methylcoelenteramide and analogs thereof for production of coelenteramide and analogs thereof
A process for producing coelenteramide or its analog in a high yield has been desired. The invention provides a process for producing di-O-methylcoelenteramide or its analog of formula (3) which comprises reacting O-methylcoelenteramine or its analog with 4-methoxyphenylacetyl halide or its analog. The invention also provides a process for producing coelenteramide or its analog, which comprises demethylation of di-O-methylcoelenteramide or its analog.
US08871930B2 Preparation method of alpha-imatinib mesylate
Disclosed is a preparation method of α-imatinib mesylate. The reaction temperature of the method is low and the yield of the crystal is improved. Furthermore, the method is applicable to the industrial production.
US08871928B2 Tricyclic compounds, preparation methods, and their uses
The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease, and/or diabetic macular edema.
US08871919B2 RNAi therapeutic for treatment of Hepatitis C infection
Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that target human cyclophilin A (CyPA) to inhibit Hepatitis C (HCV) infection. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided.
US08871918B2 Multiple exon skipping compositions for DMD
Provided are antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon skipping, and methods of use thereof to treat muscular dystrophy.
US08871917B2 Compositions for the detection of biological molecules using a two particle complex
Methods, compositions and kits for detecting analytes of interest in a sample using electrogenerated chemiluminescence are provided. Compositions comprising at least one solid support that entraps or contains an electrogenerated chemiluminescent moiety also provided.
US08871916B2 Diaryl phosphine compounds
A method for making diazo-compounds, diazonium salts thereof and other protected forms of these compounds. Diazo-compounds are prepared by reaction of a tertiary phosphine reagent carrying a reactive carbonyl group with an azide. The reaction can also generate an acyl triazene which can be converted thermally or by addition of base to form the diazo-compound or the acyl triazene can be isolated. The method is particularly useful for conversion of azides carrying one or more electron withdrawing groups to diazo-compounds. The method can be carried out in aqueous medium under mild conditions and is particularly useful for conversion of azido sugars to diazo-compounds and diazonium salts thereof under physiological conditions. Tertiary phosphine reagents, particularly those that are water-soluble, and precursors for preparation of the reagents are provided.
US08871911B2 Compositions and methods for the diagnosis and treatment of tumor
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
US08871908B2 Antibodies specific for Trop-2 and their uses
The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
US08871906B2 Deletions in domain II of pseudomonas exotoxin a that remove immunogenic epitopes
The invention provides mutated, cytotoxic forms of Pseudomonas exotoxin A (PE) comprising a furin cleavage sequence conjugated or fused directly to residues 395-613 of PE or variants of that sequence. These minimal forms of PE are smaller than previous cytotoxic forms of PE, reduce non-specific toxicity, and reduce immunogenicity due to domain II or domain Ib of PE. The invention further provides nucleic acids encoding said PEs, chimeric molecules containing them, and methods of use thereof.
US08871904B2 Processes and intermediates
The invention relates to compounds and processes useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV infections.
US08871900B2 Fibroblast growth factor (FGF) analogs and uses thereof
The invention relates to novel peptide comprising FGF-P and methods of use thereof.
US08871890B2 Curable resin composition and cured article
Disclosed is a curable resin composition which includes a ladder-type silsesquioxane (A) having an aliphatic carbon-carbon double bond in the molecule; a ladder-type silsesquioxane (B) having a Si—H bond in the molecule; and a hydrosilylation catalyst. The curable resin composition is useful as sealants typically for optical semiconductor elements. Also disclosed is a cured article which is obtained by curing the curable resin composition. The curable resin composition can give such a cured article having properties including resistance to elevated temperatures, flexibility, transparency, resistance to thermal yellowing, and resistance to photoyellowing.
US08871886B1 Polymerization product pressures in olefin polymerization
A process for making a low density polymer in a polymerization reactor system, the process comprising polymerizing an olefin monomer, and optionally an olefin comonomer, in the presence of a diluent in a polymerization reactor to make a polymerization product slurry consisting of a liquid phase and a solid phase, wherein the solid phase comprises an olefin polymer having a density of between about 0.905 g/cm3 to about 0.945 g/cm3; and discharging the polymerization product slurry from the polymerization reactor through a continuous take-off valve to make a mixture further comprising a vapor phase. The mixture comprises a pressure less than a bubble point pressure of a component in the polymerization product slurry.
US08871882B2 Method for the preparation of styrenic fluoropolymers
A method for the preparation of a fluoropolymer by means of emulsion polymerization of a reaction mixture in an aqueous medium is disclosed wherein the reaction mixture includes a fluoromonomer having the structure of wherein R1, R2, and R3 are each independently hydrogen atoms, alkyl groups, substituted alkyl groups, or halogens, wherein at least one of R1, R2, and R3 is a fluorine atom, and wherein R is each independently a substituent on the styrenic ring, n is an integer from 0 to 5 representing the number of the substituents on the styrenic ring; b) an emulsion stabilizer combination comprising: i) an anionic surfactant; and, ii) a cationic surfactant or a non-ionic surfactant; and, c) a free-radical initiator.
US08871881B2 Hydrophobic flourinated coating
The invention at hand concerns hydrophobic polymer surfaces, in particular superhydrophobic polymer surfaces, comprising at least one homo- or copolymer, which comprises at least one side chain with at least one fluoro-substituted aryl group. Furthermore, the invention at hand concerns a method for the production of polymer surfaces of this type, their use and polymers of the general formula I: wherein n is an integer between 10 and 4,500, preferably between 20 and 2,200 and particularly preferably between 100 and 670.
US08871874B2 Thermoplastic melt-mixed composition with epoxy-amino acid compound heat stabilizer and processes for their preparation
Disclosed is a thermoplastic melt-mixed composition including: a) a polyamide resin; b) a poly(amino acid)-polyol compound provided by reacting: b1) one or more amino acids selected from the group consisting of primary amino acids and secondary amino acids and combinations of these; the amino acid having no more than one hydroxyl group; and b2) one or more polyepoxy compound comprising at least two or more epoxy groups; the poly(amino acid)-polyol compound having a range of at least 10 percent conversion of epoxy equivalents of component (b1) up to, but excluding, the gel point of the components b1) and b2) and c) reinforcing agent; and, optionally, d) polymeric toughener; and f) further additives. Processes for making the composition are also disclosed.
US08871873B2 Biodegradable particle, vascular embolization material and method for producing biodegradable particles
A biodegradable particle including a block copolymer produced by copolymerization of a biodegradable copolymer having a structure composed of hydroxycarboxylic acid a1, whose homopolymer produced by homopolymerization has a glass transition point of not less than 40° C., and hydroxycarboxylic acid a2, whose homopolymer produced by homopolymerization has a glass transition point of not more than −40° C.; a water-soluble polymer comprising a functional group selected from the group consisting of a hydroxyl group, amino group and carboxylic acid group at each of both ends; and a polyvalent compound comprising 2 or more functional groups each selected from the group consisting of a hydroxyl group, amino group and carboxylic acid group; wherein a ratio of mass of said structure composed of hydroxycarboxylic acid a2 to mass of said biodegradable copolymer is 30 to 90% by mass.
US08871870B2 Synthesized resins and varnishes and prepegs and laminates made therefrom
Synthesized base resin compositions that include a raw resin and a maleimide and/or bismaleimide monomer as well as compounded varnishes that include a raw resin or synthesized base resin as well as a monomer, flame retardant and initiator as well as prepregs and laminates made using the synthesized base resin and compounded varnishes.
US08871865B2 Flame retardant thermoplastic polycarbonate compositions
Disclosed is a thermoplastic composition comprising a polycarbonate terpolymer comprising structures derived from structures (I), (II) and (III), wherein (I) is a dihydroxy compound having the structure (A): wherein n is 0 to 4 and Rf is independently a halogen atom, a C1-10 hydrocarbon group, or a C1-10 halogen substituted hydrocarbon group; (II) comprises a second dihydroxy compound derived from Formula (A) and different from (I) and wherein n and Rf are as previously defined; and (III) a third dihydroxy compound not derived from Formula (A), wherein the sum of the mol percent of all of structures (I) and (II) is greater than 45% relative to the sum of the molar amounts of all of structures (I), (II) and (III) in the polycarbonate terpolymer and wherein said polycarbonate terpolymer is amorphous; an impact modifier; an ungrafted rigid copolymer; and a flame retardant. The thermoplastic composition has improved chemical resistance and flame retardance.
US08871861B2 Silicone compound, photocurable liquid ink using the silicone compound, and method of manufacturing the ink
A silicone compound represented by the following Chemical Structure 1: wherein Y represents a substituted or non-substituted alkyl group having one to ten carbon atoms, X1, X2, and X3 independently represent methyl groups or any of Substituents A-1 to A-7, and l, m, and n are independently zero or an integer of from 1 to 6.
US08871857B2 Coating composition
A coating composition contains (A) a water-based emulsion containing (a) amino group-containing polyorganosiloxane having a self crosslinking property, (b) chlorinated polyolefin, and (c) a water dispersible polyurethane resin, and (B) spherical particles made up of a rubbery elastic body mixed and dispersed in the water-based emulsion (A). The water-based emulsion (A) can be obtained by mixing a first emulsion containing the amino group-containing polyorganosiloxane (a), a second emulsion containing the chlorinated polyolefin (b), and the water dispersion of the polyurethane resin (c). The coating composition can form a coating film excellent in preservation stability, coating uniformity, working life, having good non-tackness, water repellancy, lubricity, and excellent in adhesiveness and abrasion resistance.
US08871856B2 Wetting agents and dispersants based on mixtures of structure copolymers
The invention relates to compositions comprising two structured linear copolymers selected from the group consisting of block copolymers and gradient copolymers, these copolymers being prepared by different controlled polymerization techniques and the difference in the polydispersities of these copolymers, Δ(Mw/Mn), being ≧0.25. The invention further relates to the production of such blends and to their use as wetting agents and dispersants.
US08871852B2 Self-sealing elastomer composition
Self-sealing elastomer composition that can in particular be used as puncture-resistant layer in an inflatable article, comprising at least 30 phr of a saturated thermoplastic styrene elastomer, at most 70 phr of an unsaturated thermoplastic styrene elastomer and more than 200 phr of an oil extender. Inflatable article, such as a tire, provided with a puncture-resistant layer comprising, as self-sealing composition, an elastomer composition according to the invention. Advantageously, the puncture-resistant layer is combined with an airtight layer, for example based on butyl rubber, so as to constitute, in the inflatable article, a puncture-resistant airtight laminate.
US08871850B2 Highly dielectric film
There is provided a highly dielectric film which has high dielectric property, can be formed into a think film and is excellent in winding property (flexibility). The highly dielectric film comprises (A) a vinylidene fluoride polymer, (B) barium titanate oxide particles and/or lead zirconium titanate oxide particles, and (C) an affinity improving agent, wherein the barium titanate oxide particles and/or lead zirconium titanate oxide particles (B) and the affinity improving agent (C) are contained in amounts of 10 to 500 parts by mass and 0.01 to 30 parts by mass, respectively based on 100 parts by mass of the vinylidene fluoride polymer (A).
US08871848B2 Coating compositions for golf balls and coated golf balls
A coating composition for a golf ball and a coated golf ball are disclosed. The coating composition comprises a polyurethane and a boron-containing compound that improves the adhesion of the coating to a printed image.
US08871847B2 Composition and photo-electric converting element obtained using the same
A composition which comprises a conjugated polymer, a fullerene derivative, a first solvent, and a second solvent. When the sum of the weight of the first solvent and the weight of the second solvent is taken as 100, the weight of the first solvent is 70-97. The first solvent at 25° C. has a surface tension exceeding 25 mN/m, and the second solvent at 25° C. has a surface tension of 15-25 mN/m.
US08871846B2 Oxygen scavenging plastic material
The invention relates to a plastic material comprising a composition Z comprising the components A, B, C and D,the component A being a polyester,the component B being a polyamide,the component C being a transition metal catalyst,the component D being an organic compound selected from the group consisting of paraffins, vegetable oils, polyalkylene glycols, esters of polyols, alkoxylates, and mixtures of these substances.
US08871840B2 Pyrolytic carbon black and polymer composites manufactured therefrom
The present application provides a polymer composite comprising at least one polymer and a reclaimed pyrolyzed carbon black (pCB), wherein the pCB comprises less than about 10 μg/g of polycyclic aromatic hydrocarbons (PAH). Also provided are polymer composite and consumer-ready formulations of the low PAH pCB and methods of manufacturing such composites and formulations.
US08871835B2 Heat conductive elastomer composition
The object of the present invention is to provide a heat conductive elastomer composite useful as the heat radiating member of electric parts or electronic parts, or the like. In the present invention, an aluminum hydroxide having a surface covered with an organic coupling agent and/or an inactivated magnesium oxide, being a magnesia clinker having a surface covered with an inorganic substance and/or an organic substance, is (are) combined as heat conductive filler(s) in an elastomer composite mainly composed of a styrenic elastomer.
US08871832B2 Rubber composition for use in tire treads and pneumatic tire using the same
Rubber compositions for use in tire treads are disclosed and described. Such a composition may include a rubber component having from 40 to 80 parts by mass of a natural rubber and from 20 to 60 parts by mass of a diene rubber (other than said natural rubber) and, per 100 parts by mass thereof, from 80 to 150 parts by mass of a carbon black having a nitrogen specific surface area of from 250 to 450 m2/g and from 30 to 80 parts by mass of a resin.
US08871831B2 Modification of surfaces with polymers
A polymer formed by controlled radical polymerization includes groups that can be modified after controlled radical polymerization to form a radical. The polymer can be the reaction product of a controlled radical polymerization of radically polymerizable monomers, wherein at least one of the radically polymerizable monomers includes at least one group that can be modified after the controlled radical polymerization to form a radical.
US08871827B2 Hotmelt adhesive comprising radiation-crosslinkable poly(meth)acrylate and oligo(meth)acrylate with nonacrylic C-C double bonds
Described is a radiation-crosslinkable hotmelt adhesive comprising at least one radiation-crosslinkable poly(meth)acrylate formed to an extent of at least 60% by weight of C1 to C10 alkyl(meth)acrylates and at least one oligo(meth)acrylate which comprises nonacrylic C C double bonds and has a K value of less than or equal to 20. The hotmelt adhesive comprises a photoinitiator which may be present in the form of an additive not attached to the poly(meth)acrylate and/or not attached to the oligo(meth)acrylate, may be incorporated by copolymerization into the poly(meth)acrylate, and/or may be attached to the oligo(meth)acrylate. The hotmelt adhesive can be used for producing adhesive tapes.
US08871819B2 Glycerol ester active agent delivery systems and methods
Embodiments of the invention include glycerol esters and use of the same for active agent delivery systems and methods. In an embodiment, the invention includes an active agent eluting device including a glycerol ester, an active agent dispersed within the glycerol ester, the active agent eluting device configured to elute the active agent from the glycerol ester in response to degradation of the glycerol ester. In an embodiment, the invention includes a composition including a glycerol ester; an active agent dispersed within the glycerol ester; the active agent eluting device configured to elute the active agent from the glycerol ester in response to degradation of the glycerol ester. Other embodiments are also included herein.
US08871818B2 Gastrointestinal absorption enhancer mediated by proton-coupled transporter and its preparing method
The present invention provides a pharmaceutical preparation that can improve absorption of a pharmaceutical compound in the gastrointestinal tract and that provides, through oral administration or like method, a blood concentration from which sufficient remedial effects can be expected, and a method for producing such a preparation. The invention is directed to a pharmaceutical preparation exhibiting excellent gastrointestinal absorbability comprising a compound recognized by a proton-coupled transporter and a pH-sensitive polymer in an amount sufficient for the gastrointestinal tract to acquire a pH at which the proton-coupled transporter optimally absorbs the compound into a cell.
US08871816B2 Methods for producing vaccine adjuvants
An improved method for the manufacture of an oil-in-water emulsion involves three procedures: (i) preparation of a preliminary emulsion; (ii) microfluidization of the preliminary emulsion to reduce its droplet size; and (iii) filtration of the microfluidized emulsion through a hydrophilic membrane.
US08871810B2 Treating critically ill patients with intravenous ibuprofen
Methods of treating at least one condition chosen from pain, inflammation, and fever in a critically ill patient in need thereof, comprising administering to the critically ill patient an intravenous pharmaceutical composition comprising ibuprofen using a first dosage regimen, wherein the first dosage regimen produces a first pharmacokinetic profile in critically ill patients that is about equivalent to a second pharmacokinetic profile produced by administration of the intravenous pharmaceutical composition using a second dosage regimen of ibuprofen to non-critically ill patients, wherein the at least one condition of the critically ill patient is thereby treated.
US08871809B2 Diclofenac topical formulation
The present invention provides a gel formulation comprising diclofenac sodium which has superior transdermal flux properties, which may be used for the topical treatment of pain, such as in osteoarthritis.
US08871808B2 Over-production of dihomo linolenic acid by a mutant strain of Parietochloris incisa
The present invention is primarily directed to a mutant strain of Parietochloris incisa, characterized in comprising a substantially reduced intracellular concentration of arachidonic acid (AA) together with a substantially increased intracellular concentration of dihomo-gamma-linolenic acid 20:3ω6 (DGLA).
US08871807B2 Detergents capable of cleaning, bleaching, sanitizing and/or disinfecting textiles including sulfoperoxycarboxylic acids
The present invention relates to novel combined laundry detergent, bleach, and antimicrobial composition incorporating novel sulfoperoxycarboxylic acid compounds, and methods for making and using them. The sulfoperoxycarboxylic compounds used in compositions of the invention are storage stable, water soluble and have low to no odor. Compositions of the invention may be in the form of a liquid, a solid, or a gel. The sulfoperoxycarboxylic compounds useful in preparing compositions of the present invention can be formed from non-petroleum based renewable materials.
US08871801B2 Method of treating acquired perforating dermatosis with cantharidin
A method of treating acquired perforating dermatosis. The method has the step of applying an amount of cantharidin to an area of skin in need of treatment thereof.
US08871800B2 Statin and omega-3 fatty acids for reduction of Apo-B levels
Methods of utilizing a combined administration or a unit dosage of a combination of an HMG-CoA inhibitor and omega-3 fatty acids for the reduction of apolipoprotein-B levels. The methods are especially useful in the treatment of patients with hypertriglyceridemia or hypercholesterolemia or mixed dyslipidemia, coronary heart disease (CHD), vascular disease, atherosclerotic disease and related conditions, and for the prevention or reduction of cardiovascular, cardiac, and vascular events.
US08871799B2 Iminochromene anti-viral compounds
Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.
US08871796B2 Diaryl ether derivatives as notch sparing gamma secretase inhibitors
The invention encompasses a novel class of diaryl ether derivatives which inhibit the processing of APP by the putative γ-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included.
US08871793B2 Metaxalone cocrystals
The invention relates to improvements of the physiochemical and/or the pharmaceutical properties of metaxalone. Disclosed herein are several new cocrystals of metaxalone, including: a 1:1 metaxalone adipic acid cocrystal, a 1:0.5 metaxalone fumaric acid cocrystal, a 1:1 metaxalone salicyclic acid cocrystal, a 1:0.5 metaxalone succinic acid cocrystal, and a 1:0.5 metaxalone maleic acid cocrystal. The therapeutic uses of these metaxalone cocrystals are described as well as therapeutic compositions containing them.
US08871790B2 Heterocyclic modulators of lipid synthesis
Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.
US08871788B2 Substituted N-alkyl and N-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof
The present disclosure relates to a series of substituted N-alkyl and N-acyl tetrahydro-isoquinoline derivatives of formula (I). wherein R, R1, R2, X, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this disclosure also relates to methods of preparation of substituted N-alkyl and N-acyl tetrahydro-isoquinoline derivatives of formula (I) and intermediates therefor.
US08871787B2 Stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabicyclo [2.2.2]oct-3-yl ester
The present invention refers to a stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabicyclo[2.2.2]oct-3-yl ester and its use as medicament, in particular for the treatment of urinary incontinence or other diseases involving genitourinary disorders.
US08871786B2 Azaindazole amide compounds as CCR1 receptor antagonists
Disclosed are CCR1 inhibitor compounds of the formula (I): which are useful in the treatment of autoimmune and other diseases. Also disclosed a pharmaceutical compositions containing the same, and methods of making and using same.
US08871784B2 2-aryl-acetic acids, their derivatives and pharmaceutical compositions containing them
Selected 2-arylacetic acids, their derivatives and pharmaceutical compositions that contain these compounds are useful in inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from their activation. In particular, 2(ortho)-substituted arylacetic acids or their derivatives, such as amides and sulfonamides, lack cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrophil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.
US08871783B2 Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (cyano-methyl)-amides inhibitors of cathepsin C
This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
US08871775B2 Compounds
Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.
US08871774B2 Inhibitors of influenza viruses replication
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
US08871772B2 Therapeutic methods and compounds
The invention provides diketopiperazines of formula I. The invention also provides pharmaceutical compositions comprising the diketopiperazines, or pharmaceutically-acceptable salts or prodrugs thereof, as the active ingredient. The invention further provides therapeutic treatments that utilize the diketopiperazines of formula I, including inhibition of a proliferative disease or condition, inhibition of angiogenesis, treatment of an angiogenic disease or condition, treatment of cancer and precancerous conditions, treatment of a fibrotic disorder, treatment of a viral infection, treatment of an Akt-mediated disease or condition, inhibition of the production, release or both of matrix metalloproteinase-9, and inhibition of Akt activation.
US08871771B2 Salts of prodrugs of piperazine and substituted piperidine antiviral agents
This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.
US08871770B2 Carboxamide compounds and methods for using the same
Disclosed are carboxamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R3, R4, D, J, Z, T, p, q, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.
US08871767B2 2-arylimidazo[1,2-B]pyridazine, 2-phenylimidazo[1,2-A]pyridine, and 2-phenylimidazo[1,2-A]pyrazine derivatives
Disclosed are compounds of formula (I): where X, Y, X, A, R1, R2, and R3 are defined herein. Also disclosed are pharmaceutically acceptable salts of the compounds, compositions containing the compounds, and methods of using the compounds to treat, e.g., cancer.
US08871765B2 Substituted 4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one derivatives as poly (ADP-ribose) polymerase-1 inhibitors
Disclosed are compounds of general formula (I), their stereoisomers, regioisomers, tautomeric forms and novel intermediates involved in their synthesis, their pharmaceutically acceptable salts. These compounds are suitable as Poly(ADP-ribose)polymerase-1 inhibitors (PARP-1 inhibitors).
US08871760B2 [1,2,4]triazolo[3,4-C][1,4]oxazines as P2X7 modulators
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, and R3 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
US08871758B2 Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.
US08871753B2 Macrocyclic compounds and their use as kinase inhibitors
The present invention relates to macrocyclic compounds of Formula I: or pharmaceutically acceptable salts thereof or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are JAK/ALK inhibitors useful in the treatment of JAK/ALK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
US08871751B2 Compositions and methods relating to nuclear hormone and steroid hormone receptors including inhibitors of estrogen receptor alpha-mediated gene expression and inhibition of breast cancer
The disclosure herein relates to nuclear hormone receptors including steroid hormone receptors, for example in connection with estrogen, progesterone, and androgen. Embodiments of compositions and methods are disclosed including such relating to compounds, including substituted theophyllines, capable of functioning as inhibitors of estrogen receptor alpha-mediated gene expression and having the ability to modify cancer cells and treat cancer, including breast cancers and resistant breast cancers, particularly those that are resistant to tamoxifen. In embodiments, methods of inhibiting breast cancer cells and resistant breast cancer cells are provided. In embodiments, a useful inhibitor compound includes TPSF/NSC 97998 and other compounds.
US08871749B2 Bone-transplant or bone-filling composition comprising a dihydroxybenzoic acid derivative
Provided is a bone-transplant or bone-filling composition, which comprises a dihydroxybenzoic acid derivative which has been newly demonstrated to increase the activity of osteoblasts and so induce bone formation.
US08871745B2 Proteasome inhibitors
The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
US08871744B2 Compounds and methods for selectively targeting tumor-associated mucins
The present invention relates to pharmaceutical compositions containing tumor-selective targeted inhibitor glycoconjugates. These bioconjugates are ALK5 inhibitors covalently bound to biocompatible carrier molecules which selectively target and specifically bind to Muc4 that is overexpressed on a variety of tumor cell types. The ALK5 inhibitors are conjugated to tumor targetable glycans through a covalent linker. Preferably the acid-labile linker is designed to be stable in plasma and releases pharmacologically active inhibitors through acid-catalyzed hydrolysis in the acidic environment of the target tumor where the inhibitor activity is restored. Because the glycoconjugates are stable at physiological pH and in plasma, they advantageously reduce undesirable systemic ALK5 inhibitor activity; however, the preferable glycoconjugates are acid-labile conjugates that can be hydrolyzed upon reaching the more acid environment of the tumor.
US08871743B2 Bacterial cellulose composite with capsules embedded therein and preparation thereof
A composite of bacterial cellulose and capsules embedded therein is prepared, for example calcium alginate capsules encapsulating functional components being discretely embedded in a matrix of Gluconacetobacter xylinus cellulose. The functional components may be drugs, probiotics or nutrients, such as fungal polysaccharide.
US08871742B2 Composition and method for treating connective tissue damage
The present invention provides a composition, and a method of use thereof, for treating connective tissue damage in man and in animals, which comprises a therapeutically effective amount of chondroitin sulfate, N-acetyl D-glucosamine, and hyaluronan (hyaluronic acid). Particularly, the present invention provides a composition, and a method of use thereof, for treating connective tissue damage including, but not limited to, arthritic disease, osteoarthritis, rheumatoid arthritis, osterochondrosis dessicans, cartilage damage, joint injury, joint inflammation, joint synovitis, degenerative joint disease (DJD), post surgical DJD, traumatic injury, fracture, tendon damage, ligament damage, skeletal damage, musculoskeletal damage, fiber damage, adipose tissue damage, blood cell damage, and plasma damage. Compositions for delivery of the present invention include those for parenteral, oral, and transmucosal delivery and for direct surgical placement onto the affected tissues.
US08871739B2 Solid acid catalyzed hydrolysis of cellulosic materials
Provided are methods for the solubilization of cellulose into soluble sugars without the need for high temperatures, high pressures, strong acid solutions, and/or added water. The produced sugars can be fermented into ethanol. In one embodiment, the method comprises contacting a cellulose-containing material with a solid acid material and agitating the cellulose-containing material and the solid acid material for a time sufficient to produce an aqueous solution comprising a quantity of soluble sugars.
US08871737B2 Substituted nucleotide analogs
Disclosed herein are phosphorothioate nucleotide analogs, such as thiophosphoroamidate prodrugs and thiophosphates (including α-thiomonophosphates, α-thiodiphosphates, and α-thiotriphosphates), methods of synthesizing phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates and methods of treating viral infections, such as HCV, cancer, and/or parasitic diseases with the phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates.
US08871733B2 Treating glaucoma, cardiovascular diseases, and renal diseases
This document provides methods and materials related to treating glaucoma, ocular hypertension, cardiovascular diseases, and renal diseases. For example, this document provides isolated nucleic acid molecules and viral vectors (e.g., lentiviral vectors) containing isolated nucleic acid molecules. Methods for reducing intraocular pressure as well as symptoms and progression of cardiovascular and renal diseases also are provided.
US08871732B2 Immunostimulatory sequence oligonucleotides and methods of using the same
The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides.
US08871729B2 Treatment of CNS conditions
Methods and compositions for the treatment of pathologic conditions of the central nervous system (CNS) by means of intranasal administration of a composition that modulates, by means of RNA interference, the expression and/or activity of genes involved in above-mentioned conditions.
US08871728B2 Non-peptide macrocyclic histone deacetylese (HDAC) inhibitors and methods of making and using thereof
Compounds of Formula I or II, and methods of making and using thereof, are described herein. M represents a macrolide subunit, E is a C1-6 group, optionally containing one or more heteroatoms, D is an alkyl or aryl group, A is a linking group connected to D, B is an alkyl, alkylaryl or alkylheteroaryl spacer group, ZBG is a Zinc Binding Group, R1, R2 and R4 are independently are selected from hydrogen, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-6 alkanoate group, a C2-6 carbamate group, a C2-6 carbonate group, a C2-6 carbamate group, or a C2-6 thiocarbamate group, R3 is hydrogen or —OR5, R5 is selected from a group consisting of Hydrogen, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, C1-6 alkanoate group, C2-6 carbamate group, C2-6 carbonate group, C2-6 carbamate group, or C2-6 thiocarbamate group.
US08871727B2 Ectoparasiticidal methods and formulations
Provided are novel methods and formulations for topically controlling ectoparasite infestations in animals using spinetoram or a pharmaceutically acceptable salt thereof.
US08871726B2 C-aryl glucoside derivative, preparation method therefor, and use thereof
The present invention relates to a C-aryl glucoside derivative of Formula (I) below, a preparation method therefor and a use thereof, wherein X, R1, R2, R3, R4, m and n are as defined in specification. The derivative of the present invention is a sodium-glucose co-transporter 2 (SGLT-2) inhibitor associated with glucose reabsorption of bowel or kidney, and has a good urine glucose excreting effect, thus being useful as a therapeutic agent for treating diabetes and related diseases.
US08871724B2 Oligopeptidic compounds and uses thereof
The present invention provides an oligopeptidic compound comprising a PCNA interacting motif, or a nucleic acid molecule comprising a sequence encoding said oligopeptidic compound, for use in therapy, wherein the PCNA interacting motif is X1X2X3X3′X1′- (SEQ ID NO: 1), wherein X1 and X1′- are independently selected from the group of basic amino acids, X2 is a lipophilic amino acid and X3 and X3′ are independently selected from the group of uncharged amino acids; and wherein the oligopeptidic compound is further characterized by at least one of the following: (i) the oligopeptidic compound comprises at least one signal sequence; (ii) the PCNA interacting motif is [K/R]-F-[L/I/V]-[L/I/V]-[K/R] (SEQ ID NO: 27). Particularly the therapy may be the treatment of a disorder or condition where it is desirable to inhibit the growth of cells, for example a hyperproliferative disorder, or a treatment which involves cytostatic therapy e.g., myeloablation. In certain aspects the compounds of the invention may be used as cytostatic agents in their own right. In other aspects of the invention oligopeptidic compounds comprising such a motif may be used in conjunction with cytostatic agents or with radiotherapy.
US08871723B2 Glycan modified soluble receptors and binding protein and their use
An invention relates to a glycan-modified soluble receptor or binding protein of a cytokine, growth factor, lipoprotein or oxidized lipoprotein, modified to carry a terminal Gal, GlcNAc or GalNAc.
US08871721B2 Methods for inhibiting peritoneal dissemination of cancer cells
A pharmaceutical composition for treating or preventing peritoneal dissemination is provided. The pharmaceutical composition includes an effective dose of connective tissue growth factor (CTGF) and a pharmaceutically acceptable carrier thereof.
US08871715B2 Use of selenium compounds, especially selenium yeasts for altering cognitive function
The present invention relates to compositions and methods for altering cell function. In particular, the present invention provides compositions comprising selenium (e.g., SEL-PLEX) and methods of using the same (e.g., as a therapeutic and/or prophylactic treatment for neurodegenerative disease). Additionally, the present invention demonstrates that specific forms of selenium (e.g., SEL-PLEX) possess the ability to alter expression of genes associated with disease and/or aging while other forms of selenium (e.g., selenomethionine) do not.
US08871714B2 Hyperglycosylated human coagulation factor IX
The invention relates to hyperglycosylated human coagulation factor IX polypeptides, to processes for preparing said polypeptides, to pharmaceutical compositions comprising said polypeptides and to the use of the compounds for the treatment of diseases alleviated by human coagulation factor IX, in particular, but not exclusively hemophilia.
US08871711B2 Fibroblast growth factor-9 promotes hair follicle regeneration after wounding
The present invention provides methods for treating hair loss, treating, inhibiting, or suppressing a degenerative skin disorder, treating androgenetic alopecia (AGA), generating new hair follicles (HF), and increasing the size of existing HF. The methods comprise epidermal disruption or administration of wnt, and administration of a fibroblast growth factor-9 polypeptide or another compound that upregulates sonic hedgehog gene signaling.
US08871702B2 Soil-release polymers having a grey-inhibiting effect and having high stability in solution
The invention relates to polyesters, obtainable by means of polymerization of the components including (a) one or more sulfo group-free aromatic dicarboxylic acids and/or salts thereof and/or anhydrides thereof and/or esters thereof, b) optionally one or more sulfo group-containing dicarboxylic acids, salts thereof and/or anhydrides thereof and/or esters thereof, c) 1,2-propylene glycol, d) ethylene glycol, e) one or more compounds of the formula (1) R1O(CHR2CHR3O)nH (1), where R1 is a linear or branched, saturated or unsaturated alkyl group having from 1 to 22 C atoms, R2 and R3, independently of one another, are hydrogen or an alkyl group having from 1 to 4 carbon atoms, and N is an integer of from 1 to 50, f) optionally one or more compounds of the formula (2) H—(OCH2CH2)m—SO3X (2), in which m is an integer from 1 to 10 and X is hydrogen or an alkali metal ion, and g); optionally one or more crosslinking polyfunctional compounds, provided that at least one of the components b) or f) is present, and provided further that the molar ratio of the components c) 1,2-propylene glycol to d) ethylene glycol is greater than or equal to 1.70.
US08871701B2 Emulsions for removal and prevention of deposits
The invention relates to an aqueous cleansing emulsion comprising a hydrophobic component H1 selected from the group consisting of the following categories: (i) aliphatic C10- or C15-terpene hydrocarbons; (ii) aliphatic C10- or C15-terpenoids; (iii) aliphatic C15-C40-hydrocarbons; and (iv) C6-C30-carboxylic acid C1-C30-alkyl esters. A hydrophobic component H2 selected from the group consisting of the following categories: (iii) aliphatic C15-C40-hydrocarbons; (iv) C6-C30-carboxylic acid C1-C30-alkyl esters; (v) aliphatic C6-C19-hydrocarbons; (vi) aromatic C10- or C15-terpenoids; (vii) aliphatic or aromatic C20-, C25-, C30- or C35-terpenoids; (viii) essential, animal or vegetable oils; and (ix) silicon oils. Furthermore, the emulsion contains an emulsifier E1 having a HLB value of 4±2; an emulsifier E2 having a HLB value of 9±2; and optionally, an emulsifier E3 having an HLB value of 16±4.
US08871696B2 1,3,2-dioxaphosphorinane, 2-sulfide derivatives for use as anti-wear additives in lubricant compositions
The present disclosure relates to a non-acidic, sulfur-containing, phosphorus-containing compound of the formula I where R1, R2, R3, R4, R5, R6, and R7 are as defined herein. Such a compound may exhibit improved antiwear performance and thermal stability in lubricating compositions.
US08871693B2 Volatile-phosphorus free gelling agents
A gelling agent for a hydrocarbon fracturing fluid is disclosed, comprising the general formula of: in which X is an OR1, NR1R2, or SR1 group, R1 is an organic group having 2-24 carbon atoms, and R2 is an organic group or a hydrogen. Y is an NR3R4 or SR3 group, R3 is an organic group having 2-24 carbon atoms, and R4 is an organic group or a hydrogen. A method of making a gelling agent for a hydrocarbon fracturing fluid is also disclosed. Phosphorus oxyhalide is reacted with a chemical reagent to produce substantially only diester phosphorus oxyhalide, the chemical reagent comprising at least one of an organic alcohol having 2-24 carbon atoms, an organic amine with an organic group having 2-24 carbon atoms, and an organic sulfide having 2-24 carbon atoms. The diester phosphorus oxyhalide is then hydrolyzed to produce diester phosphoric acid.
US08871692B2 Water-soluble polymers for oil recovery
The present invention refers to the use of anionic water-soluble polymers being partially or totally neutralized with an organic counter-ion for oil filed application, especially tertiary oil recovery steps.
US08871686B2 Methods of identifying a pair of binding partners
The invention relates to methods of identifying a binding partner of a target molecule within a plurality of analyte molecules, including a plurality of peptides and/or proteins. The target molecule is physically combined with a target labeling nucleic acid molecule. Each member of the plurality of analyte molecules is physically linked to an analyte labeling nucleic acid molecule, each analyte labeling nucleic acid molecule comprising a selected nucleotide sequence. This specific nucleotide sequence may include a sequence encoding a peptide/protein combined therewith. The target molecule is contacted with the analyte molecules and a complex between the target molecule and an analyte molecule forms. The mixture is subdivided into compartments. The target labeling nucleic acid molecule and the analyte labeling nucleic acid molecule are linked and the plurality of compartments allowed to disintegrate. The linked nucleic acid molecule is retrieved and the sequence determined.
US08871674B2 Radioactive-substance-absorbent, radioactive-substance-absorbent production device, and bag unit
By fibrillated cellulose fibrillated in fiber form and humidified as a water permeable polymeric substance of botanical origin and a radioactive-substance-absorbent obtained by mixing with zeolite as a granulated inorganic porous crystal, radioactive substances released and spilled in a accident etc. in a nuclear facility etc. may be efficiently and easily collected and removed at a low cost.
US08871673B2 Catalyst production method therefor and use thereof for decomposing N2O
Catalysts for the decomposition of N2O into nitrogen and oxygen in the gas phase, which comprises a porous support composed of polycrystalline or vitreous inorganic material, a cerium oxide functional layer applied thereto and a layer of oxidic cobalt-containing material applied thereto are described.The catalysts can be used, in particular, as secondary or tertiary catalysts in nitric acid plants.
US08871672B2 Platinum-containing catalyst and method of producing the same, electrode and electrochemical device
In one example embodiment, a core-shell type platinum-containing catalyst is allowed to reduce the amount of used platinum and has high catalytic activity and stability. In one example embodiment, the core-shell type platinum-containing catalyst includes a core particle (with an average particle diameter R1) made of a non-platinum element and a platinum shell layer (with an average thickness ts) satisfying 1.4 nm≦R1≦3.5 nm and 0.25 nm≦ts≦0.9 nm. The core particle includes an element satisfying Eout≧3.0 eV, where average binding energy relative to the Fermi level of 5d orbital electrons of platinum present on an outermost surface of the shell layer is Eout. In a fuel cell including a platinum-containing catalyst which contains a Ru particle as a core particle, the output density at a current density of 300 mA/cm2 is 70 mW/cm2 or over, and an output retention ratio is approximately 90% or over.
US08871671B2 Hydrogen storage unit
A hydrogen storage alloy unit comprises a porous body 7 having a large number of holes (spaces) 9 allowing hydrogen atoms to pass through, and a hydrogen storage alloy covering a surface of the porous body 7, inclusive of surfaces of the holes thereof. The hydrogen storage alloy includes a hydrogen storage base formed of a hydrogen storage material, and a catalytic layer covering a surface of the hydrogen storage base. The porous body 7 is formed of an assembly of hydrogen storage fibers 8 formed by vapor-depositing the hydrogen storage alloy onto nanofibers.
US08871664B2 Refractory filler, sealing material using same, and manufacturing method for refractory filler
Provided is a manufacturing method for a refractory filler, comprising melting a raw material batch and cooling the resultant melt to precipitate willemite as a main crystal phase.
US08871662B2 Compositions for mineral wool
The subject of the invention is a mineral wool, the glass fibers of which have a chemical composition substantially free of boron oxide and comprising the following constituents in the limits defined below, expressed in percentages by weight: 60 to 75 SiO2; 0 to 4 Al2O3; 17 to 22 Na2O; 5 to 15 CaO; 0 to 2 Fe2O3; and 0 to 3 P2O5.
US08871657B2 Method of manufacture of a composite concrete article
A method of manufacturing a composite concrete article comprising forming a textile structure, removing material from regions of the textile structure to create voids in the textile structure and incorporating the textile structure into a body of wet uncured concrete such that the concrete flows into the voids created in the textile structure, embedding the textile structure into the concrete, whereby the textile structure defines at least a portion of a surface of the cured concrete article.
US08871651B1 Mask formation processing
A mask for use in fabricating one or more semiconductor devices is fabricated by: providing sacrificial spacing structures disposed over a substrate structure, and including protective hard masks at upper surfaces of the spacing structures; disposing a sidewall spacer layer conformally over the sacrificial spacing structures; selectively removing the sidewall spacer layer from above the sacrificial spacing structures to expose the protective hard masks of the spacing structures, the selectively removing including leaving sidewall spacers along sidewalls of the sacrificial spacing structures; providing a protective material over the substrate structure; and removing the exposed protective hard masks from the sacrificial spacing structures, and thereafter, removing remaining sacrificial spacing structures and the protective material, leaving the sidewall spacers over the substrate structure as a mask.
US08871647B2 Group III nitride substrate, semiconductor device comprising the same, and method for producing surface-treated group III nitride substrate
A group III nitride substrate in one embodiment has a surface layer. The surface layer contains 3 at. % to 25 at. % of carbon and 5×1010 atoms/cm2 to 200×1010 atoms/cm2 of a p-type metal element. The group III nitride substrate has a stable surface.
US08871643B2 Lateral semiconductor device and manufacturing method for the same
A manufacturing method for manufacturing a lateral semiconductor device having an SOI (Silicon on Insulator) substrate, the lateral semiconductor device comprising a semiconductor layer that includes a buried oxide layer and a drift region, the manufacturing method comprising an etching process of etching, by a predetermined depth, a LOCOS oxide that projects from a surface of the semiconductor layer by a predetermined thickness and is embedded in the semiconductor layer by a predetermined thickness, and a trench forming process of simultaneously forming a first trench extending from the drift region toward the buried oxide layer, and a second trench extending from a portion obtained by the etching in the etching process toward the buried oxide layer, at a same etching rate, and stopping forming the first trench and the second trench at a time when the second trench reaches the buried oxide layer.
US08871640B2 Method of manufacturing semiconductor chip
A method of manufacturing a semiconductor chip including an integrated circuit and a through-electrode penetrating a semiconductor layer includes the steps of preparing a first substrate including a release layer and a semiconductor layer formed on the release layer; forming an integrated circuit in the semiconductor layer; forming, in the semiconductor layer, a hole or groove having a depth that does not reach the release layer; filling the hole or the groove with an electrical conductor; bonding a second substrate to the semiconductor layer to form a bonded structure; separating the bonded structure at the release layer to prepare the second substrate to which the semiconductor layer is transferred; and removing at least a portion of the reverse surface side of the semiconductor layer exposed by the separation to expose the bottom of the electrical conductor.
US08871639B2 Semiconductor devices and methods of manufacture thereof
Semiconductor devices and methods of manufacture thereof are disclosed. In one embodiment, a method of manufacturing a semiconductor device includes providing a workpiece including an insulating material layer disposed thereon. The insulating material layer includes a trench formed therein. The method includes forming a barrier layer on the sidewalls of the trench using a surface modification process and a surface treatment process.
US08871636B2 Fluorine depleted adhesion layer for metal interconnect structure
A line trough and a via cavity are formed within a dielectric layer comprising a fluorosilicate glass (FSG) layer. A fluorine depleted adhesion layer is formed within the line trough and the via cavity either by a plasma treatment that removes fluorine from exposed surfaces of the FSG layer, or by deposition of a substantially fluorine-free dielectric layer. Metal is deposited within the line trough and the via cavity to form a metal line and a metal via. The fluorine depleted adhesion layer provides enhanced adhesion to the metal line compared with prior art structures in which a metal line directly contacts a FSG layer. The enhanced adhesion of metal with an underlying dielectric layer provides higher resistance to delamination for a semiconductor package employing lead-free C4 balls on a metal interconnect structure.
US08871632B2 Reduction of pore fill material dewetting
In one embodiment, a program storage device readable by a machine, tangibly embodying a program of instructions executable by the machine for performing operations, includes operations comprising: providing a structure comprising a first layer overlying a substrate, where the first layer comprises a dielectric material having a plurality of pores; applying a filling material to a surface of the first layer, where the filling material comprises a polymer and at least one additive, where the at least one additive comprises at least one of a surfactant, a high molecular weight polymer and a solvent (e.g., a high boiling point solvent); and after applying the filling material, heating the structure to enable the filling material to at least partially fill the plurality of pores uniformly across an area of the first layer, where heating the structure results in residual filling material being uniformly left on the surface of the first layer.
US08871627B2 Semiconductor device having low dielectric insulating film and manufacturing method of the same
A semiconductor device includes a semiconductor substrate on which a structure portion is provided except a peripheral portion thereof, and has a laminated structure including low dielectric films and wiring lines, the low dielectric films having a relative dielectric constant of 3.0 or lower and a glass transition temperature of 400° C. or higher. An insulating film is formed on the structure portion. A connection pad portion is arranged on the insulating film and connected to an uppermost wiring line of the laminated structure portion. A bump electrode is provided on the connection pad portion. A sealing film made of an organic resin is provided on a part of the insulating film which surrounds the bump electrode. Side surfaces of the laminated structure portion are covered with the insulating film and/or the sealing film.
US08871625B2 Spacer structure of a field effect transistor with an oxygen-containing layer between two oxygen-sealing layers
A method of fabricating a spacer structure which includes forming a dummy gate structure comprising a top surface and sidewall surfaces over a substrate and forming a spacer structure over the sidewall surfaces. Forming the spacer structure includes depositing a first oxygen-sealing layer on the dummy gate structure and removing a portion of the first oxygen-sealing layer on the top surface of the dummy gate structure, whereby the first oxygen-sealing layer remains on the sidewall surfaces. Forming the spacer structure further includes depositing an oxygen-containing layer on the first oxygen-sealing layer and the top surface of the dummy gate structure. Forming the spacer structure further includes depositing a second oxygen-sealing layer on the oxygen-containing layer and removing a portion of the second oxygen-sealing layer over the top surface of the dummy gate structure. Forming the spacer structure further includes thinning the second oxygen-sealing layer.
US08871623B2 Methods and devices for forming nanostructure monolayers and devices including such monolayers
Methods are provided for forming a nanostructure array. An example method includes providing a first layer, providing nanostructures dispersed in a solution comprising a liquid form of a spin-on-dielectric, wherein the nanostructures comprise a silsesquioxane ligand coating, disposing the solution on the first layer, whereby the nanostructures form a monolayer array on the first layer, and curing the liquid form of the spin-on-dielectric to provide a solid form of the spin-on-dielectric. Numerous other aspects are provided.
US08871618B2 In-situ fabrication method for silicon solar cell
An in-situ fabrication method for a silicon solar cell includes the following steps: pretreating a silicon chip; placing the pretreated silicon chip in an implantation chamber of a plasma immersion ion implantation machine; completing the preparation of black silicon via a plasma immersion ion implantation process; making a PN junction and forming a passivation layer on the black silicon; after making the PN junction and forming the passivation layer, removing the black silicon from the plasma immersion ion implantation machine; preparing a metal back electrode on the back of the black silicon; preparing a metal grid on the passivation layer; obtaining a solar cell after encapsulation. Said method enables black silicon preparation, PN junction preparation, and passivation layer formation in-situ, greatly reducing the amount of equipment needed for the preparation of solar cells and the preparation cost. In addition, the method is simple and easy to control.
US08871616B2 Methods of fabricating thin film transistor and organic light emitting diode display device having the same
A thin film transistor (TFT), an OLED device having the TFT and a method of fabricating the same and a method of fabricating an organic light emitting diode (OLED) display device that includes the TFT. The method of fabricating a TFT includes providing a substrate, forming a buffer layer on the substrate, forming an amorphous silicon layer pattern on the buffer layer, forming a metal layer on an entire surface of the substrate, forming a semiconductor layer by applying an electrical field to the metal layer to crystallize the amorphous silicon layer pattern, forming source and drain electrodes connected to the semiconductor layer by patterning the metal layer, forming a gate insulating layer on the entire surface of the substrate, forming a gate electrode on the gate insulating layer to correspond to the semiconductor layer and forming a protective layer on the entire surface of the substrate.
US08871611B2 Method for molecular adhesion bonding at low pressure
A method for bonding first and second wafers by molecular adhesion. The method includes placing the wafers in an environment having a first pressure (P1) greater than a predetermined threshold pressure above which initiation of bonding wave propagation is prevented, bringing the first wafer and the second wafer into alignment and contact, and spontaneously initiating the propagation of a bonding wave between the wafers after they are in contact solely by reducing the pressure within the environment to a second pressure (P2) below the threshold pressure.
US08871603B2 Semiconductor device and method for low resistive thin film resistor interconnect
The invention relates to a semiconductor device and a method of manufacturing an electronic device. A first conductive layer (first metal interconnect layer) is deposited. There is an insulating layer (first intermetal dielectric) layer deposited. A resistive layer is deposited on top of the insulating layer and structured in order to serve as a thin film resistor. A second insulating layer (second intermetal dielectric) is then deposited on top of the resistive layer. A first opening is etched into the insulating layers (first and second intermetal dielectric) down to the first conductive layer. A second opening is etched into the insulating layers (first and second intermetal dielectrics) down to the first conductive layer. A cross-sectional plane of the second opening is arranged such that it at least partially overlaps the resistive layer of the thin film resistor in a first direction.
US08871597B2 High gate density devices and methods
A method of forming a semiconductor device includes providing a semiconductor substrate and forming a plurality of dummy gate structures in the substrate. The method further includes forming sidewall spacers on sidewalls of the dummy gate structures and forming a plurality of epitaxial growth regions between the dummy gate structures. After forming the plurality of epitaxial growth regions, one of the dummy gate structures is removed to form an isolation trench, which is filled with a dielectric layer to form an isolation feature. The remaining dummy gate structures are removed to form gate trenches, and gate structures are formed in the gate trenches.
US08871591B2 Methods of manufacturing a vertical type semiconductor device
According to example embodiments of inventive concepts, a method includes forming cell patterns and insulating interlayers between the cell patterns on the substrate. An upper insulating interlayer including initial and preliminary contact holes is formed on an uppermost cell pattern. A first reflection limiting layer pattern and a first photoresist layer pattern are formed for exposing a first preliminary contact hole while covering inlet portion of the initial and preliminary contact holes. A first etching process is performed on layers under the first preliminary contact hole to expose the cell pattern at a lower position than a bottom of the first preliminary contact hole. A partial removing process of sidewall portions of the first reflection limiting layer pattern and the first photoresist layer pattern and an etching process on exposed layers through bottom portions of the preliminary contact holes are repeated for forming contact holes having different depths.
US08871588B2 Reverse construction integrated circuit
A method of fabricating a memory cell comprises forming a plurality of doped semiconductor layers on a carrier substrate. The method further comprises forming a plurality of digit lines separated by an insulating material. The digit lines are arrayed over the doped semiconductor layers. The method further comprises etching a plurality of trenches into the doped semiconductor layers. The method further comprises depositing an insulating material into the plurality of trenches to form a plurality of electrically isolated transistor pillars. The method further comprises bonding at least a portion of the structure formed on the carrier substrate to a host substrate. The method further comprises separating the carrier substrate from the host substrate.
US08871587B2 Complementary stress memorization technique layer method
A process of forming a CMOS integrated circuit by forming a first stressor layer over two MOS transistors of opposite polarity, removing a portion of the first stressor layer from the first transistor, and forming a second stressor layer over the two transistors. A source/drain anneal is performed, crystallizing amorphous regions of silicon in the gates of the two transistors, and subsequently removing the stressor layers. A process of forming a CMOS integrated circuit by forming two transistors of opposite polarity, forming a two stressor layers over the transistors, annealing the integrated circuit, removing the stressor layers, and siliciding the transistors. A process of forming a CMOS integrated circuit with an NMOS transistor and a PMOS transistor using a stress memorization technique, by removing the stressor layers with wet etch processes.
US08871585B2 Manufacturing method of semiconductor device and semiconductor device
A manufacturing method of a semiconductor device includes: forming a first gate insulating film on a semiconductor substrate in first and second regions in an active area; forming first gate electrodes on the first gate insulating film in the first and second regions; forming source/drain regions by introducing impurities at both sides of the first gate electrode in the first and second regions; performing heat treatment of activating the impurities; forming a stress liner film so as to cover the whole surface of first gate electrodes in the first and second regions; removing the stress liner film at an upper portion of the first gate electrode in the second region while allowing the stress liner film at least at a portion in the first region to remain to expose the upper portion of the first gate electrode in the second region; forming a groove by removing the first gate electrode in the second region; and forming a second gate electrode in the groove.
US08871581B2 Enhancement mode III-nitride FET
A III-nitride switch includes a recessed gate contact to produce a nominally off, or an enhancement mode, device. By providing a recessed gate contact, a conduction channel formed at the interface of two III-nitride materials is interrupted when the gate electrode is inactive to prevent current flow in the device. The gate electrode can be a schottky contact or an insulated metal contact. Two gate electrodes can be provided to form a bi-directional switch with nominally off characteristics. The recesses formed with the gate electrode can have sloped sides. The gate electrodes can be formed in a number of geometries in conjunction with current carrying electrodes of the device.
US08871578B2 Method for manufacturing thin film transistor
A method for manufacturing a thin film transistor includes forming a semiconductor layer, a wiring layer and a patterned mask layer in sequence on a substrate on which a gate electrode and a gate insulating layer are formed; patterning the wiring layer and the semiconductor layer based on the patterned mask layer while irradiating external light; removing at least a part of the mask layer; forming a channel portion by etching the wiring layer while controlling irradiation of the external light. Further, the method for manufacturing the thin film transistor can obtain an improved structure by forming the semiconductor layer made of an oxide which reacts to external light irradiated thereto, thus capable of adjusting a selectivity between the semiconductor layer and the wiring layer.
US08871577B2 Thin film transistor and manufacturing method thereof
A thin film transistor is provided. A thin film transistor according to an exemplary embodiment of the present invention includes: a substrate; a gate line disposed on the substrate and including a gate electrode; a semiconductor layer disposed on the substrate and including at least a portion overlapping the gate electrode; a gate insulating layer disposed between the gate line and the semiconductor layer; and a source electrode and a drain electrode disposed on the substrate and facing each other over a channel region of the semiconductor layer. The gate insulating layer includes a first region and a second region, the first region corresponds to the channel region of the semiconductor layer, the first region is made of a first material, the second region is made of a second material, and the first material and the second material have different atomic number ratios of carbon and silicon.
US08871566B2 Method of manufacturing thin film transistor
A thin film transistor includes a gate electrode, a first insulating layer on the gate electrode, a semiconductor layer on the gate electrode and separated from the gate electrode by the first insulating layer, the semiconductor layer including a channel region corresponding to the gate electrode, a source region, and a drain region, a hydrogen diffusion barrier layer on the semiconductor layer, the hydrogen diffusion barrier layer covering the channel region and exposing the source and drain regions, and a second insulation layer on the source and drain regions and on the hydrogen diffusion barrier layer, such that the hydrogen diffusion barrier layer is between the second insulation layer and the channel region.
US08871563B2 Method of manufacturing organic-light-emitting-diode flat-panel light-source apparatus
A method of manufacturing an organic-light-emitting-diode (OLED) flat-panel light-source apparatus. The method includes depositing a metal layer on a substrate and patterning the metal layer to form a plurality of subsidiary electrodes, forming an insulating layer on the substrate including the plurality of subsidiary electrodes and forming a first subsidiary electrode layer by etching the insulating layer until some of the plurality of subsidiary electrodes are exposed, and sequentially forming an anode, an organic emission layer (EML), and a cathode on the substrate on which the first subsidiary electrode layer is formed.
US08871561B2 Variable resistance nonvolatile storage device and method for manufacturing the same
Provided is a method for manufacturing a variable resistance nonvolatile storage device, which prevents electrical conduction between lower electrodes and upper electrodes of variable resistance elements in the memory cell holes. The method includes: forming lower copper lines; forming a third interlayer insulating layer; forming memory cell holes in the third interlayer insulating layer, an opening diameter of upper portions of the memory cell holes being smaller than bottom portions; forming a metal electrode layer on the bottom of each memory cell holes by sputtering; embedding and forming a variable resistance layer in each memory cell hole; and forming upper copper lines connected to the variable resistance layer embedded and formed in each memory cell hole.
US08871558B2 Method of manufacturing organic electroluminescent display
In a method of manufacturing an organic electroluminescent display, when a substrate including first and second pixel areas is prepared, a first mask including openings is disposed on the substrate to respectively correspond to the first and second pixel areas, and a second mask including an opening corresponding to the first pixel area is disposed on the first mask to expose the first pixel area and cover the second pixel area. Then, a first organic light emitting material is provided to the substrate to form the first organic light emitting material in the first pixel area and the second mask is removed from the substrate to expose the first and second pixel areas. Thereafter, a second organic light emitting material is provided to the substrate to form the second light emitting material in the first and second pixel areas and the first mask is removed from the substrate.
US08871550B2 Method for processing a wafer at unmasked areas and previously masked areas to reduce a wafer thickness
A method for processing a wafer having microelectromechanical system structures at the first main surface includes applying a masking material at the second main surface and structuring the masking material to obtain a plurality of masked areas and a plurality of unmasked areas at the second main surface. The method further includes anisotropically etching the wafer from the second main surface at the unmasked areas to form a plurality of recesses. The masking material is then removed at least at some of the masked areas to obtain previously masked areas. The method further includes anisotropically etching the wafer from the second main surface at the unmasked areas and the previously masked areas to increase a depth of the recesses and reduce a thickness of the wafer at the previously masked areas.
US08871547B2 Method for fabricating vertical light emitting diode (VLED) structure using a laser pulse to remove a carrier substrate
A method for fabricating a vertical light-emitting diode (VLED) structure includes the steps of providing a carrier substrate, and forming a semiconductor structure on the carrier substrate having a p-type confinement layer, a multiple quantum well (MQW) layer in electrical contact with the p-type confinement layer configured to emit electromagnetic radiation, and an n-type confinement layer in electrical contact with the multiple quantum well (MQW) layer. The method also includes the steps of removing the carrier substrate using a laser pulse to expose an inverted surface of the n-type confinement layer, and forming a metal contact on the surface of the n-type confinement layer.
US08871544B2 Vertical light-emitting devices having patterned emitting unit and methods of manufacturing the same
Example embodiments are directed to a light-emitting device including a patterned emitting unit and a method of manufacturing the light-emitting device. The light-emitting device includes a first electrode on a top of a semiconductor layer, and a second electrode on a bottom of the semiconductor layer, wherein the semiconductor layer is a pattern array formed of a plurality of stacks. A space between the plurality of stacks is filled with an insulating layer, and the first electrode is on the insulating layer.
US08871542B2 Method of manufacturing organic light emitting display apparatus, and organic light emitting display apparatus manufactured by using the method
A method of manufacturing an organic light emitting display device and an organic light emitting display device manufactured using the method, which are suitable for manufacturing large-sized display devices on a mass scale and can be used for high-definition patterning. The method includes consecutively forming organic layers on a substrate on which a plurality of panels are arranged parallel to each other; forming a second electrode on the organic layers, for each of the panels; forming a passivation layer on the second electrode on each of the panels to cover the second electrode; and removing a part of the organic layers that exists between the passivation layer on the second electrode of one of the panels and the passivation layer on the second electrode of an adjacent one of the panels.
US08871541B2 Touch panel of an organic light emitting diode display and manufacturing method thereof
An organic light emitting diode display includes: an organic light emitting display panel including a first substrate including an organic light emitting element and a second substrate combined with the first substrate; a touch substrate combined with the organic light emitting display panel; a first electrode pattern having a plurality of pads, formed on the touch substrate, and connected by an access unit in a first direction; a second electrode pattern having a plurality of pads; a wire electrically connected to one of the first electrode pattern and the second electrode pattern; an insulation layer formed on the first and second electrode patterns and including a contact hole; and a connection electrode disposed in the contact hole and electrically connecting pads of the second electrode pattern in a second direction crossing the first direction, wherein the first electrode pattern, the second electrode pattern, and the wire are formed simultaneously on the same plane.
US08871535B2 Method for manufacturing LED
A method for manufacturing an LED package includes following steps: providing a base with an LED chip mounted on the base; providing a porous carrier with a plurality of holes, and disposing the base on the porous carrier; providing a film with a phosphor layer attached on the film; providing a mold, and putting the porous carrier, the base, the LED chip, and the film into the mold; extracting air from the mold to an external environment through the holes of the porous carrier, and/or, blowing air toward the film to urge the film to move toward the LED chip, resulting in that the film is conformably attached onto the LED chip and the base; and solidifying the phosphor layer on the LED chip by means of heating whereby the phosphor is conformably and securely attached on the LED chip.
US08871532B2 Method of manufacturing semiconductor device
A method of manufacturing a semiconductor device which solves a problem with a burn-in process where current and voltage are applied to finished semiconductor devices at high-temperature. The method uses an organic multilayer wiring substrate for a burn-in board in which power supply/grounding wiring is formed with microscopic openings formed at least almost all over the areas around sockets over the front or back surface of the substrate. For increasing the supply voltage and reference voltage for the burn-in board and other purposes, whenever possible, signal wires are disposed in inner wiring layers of the board. The related-art burn-in board which has a solid or blanket-type conductor pattern in an outermost layer as wiring for supply or reference voltage may cause an insulating protective film over the metal wiring to peel due to weak adhesion between the wiring and film when thermal cycles are repeated. The method solves the problem.
US08871529B2 Method for manufacturing integrated circuit structure with magnetoresistance component
A method or manufacturing an integrated circuit structure with a magnetoresistance component is provided. A substrate is provided. A circuit structure layer including a metal pad is formed on the substrate. A dielectric layer is formed on the circuit structure. A metal damascene structure is formed in the dielectric layer. An opening is formed in the dielectric layer so as to form a step-drop. A magnetoresistance material layer is formed on the dielectric layer after forming the metal damascene structure and the opening. A photolithography process is applied to pattern the magnetoresistance material layer to form a magnetoresistance component electrically connected to the metal damascene structure.
US08871528B2 Medium patterning method and associated apparatus
According to one embodiment, a method for patterning a medium having a patterned hard mask applied thereon is disclosed herein. The patterned hard mark includes a plurality of apertures exposing portions of the medium. The method includes directing ions toward the medium, implanting a portion of the ions into the exposed portions of the medium, removing a layer of the patterned hard mask with another portion of the ions, and depositing hard mask material onto the patterned hard mask. Depositing hard mask material onto the exposed portions of the medium may follow implantation of the portion of the ions into the exposed portions of the medium.
US08871520B2 Uracil-specific fluorescence detection reaction and method for examining dihydropyrimidine dehydrogenase deficiency
The invention provides a method of detecting uracil. The method comprises reacting uracil with a compound represented by the formula (I) in the presence of an oxidant and a base to produce a fluorescent compound represented by the formula (II).
US08871519B2 Method of qualifying material for use in cleaning of alkylene oxide equipment
The present invention relates to methods for qualifying material for using in the cleaning of alkylene oxide equipment. Qualified material is not expected to contribute to the formation of determinable amounts of alkylene oxide by-products. Methods of cleaning alkylene oxide equipment, and alkylene oxide processes incorporating these methods are also provided.
US08871518B2 Monoclonal antibody for analyzing high-molecular weight adiponectin and utilization of same
A monoclonal antibody that does not show a crossreactivity with middle-molecular weight (MMW) adiponectin and specifically reacts with high-molecular weight (HMW) adiponectin alone is disclosed. The monoclonal antibody of the present invention can be produced by using HMW adiponectin as an antigen. According to the monoclonal antibody of the present invention, a convenient, high-accurate, and versatile reagent for analyzing HMW adiponectin can be provided.
US08871515B2 Construction of fully-deleted adenovirus-based gene delivery vectors and uses thereof
The embodiments disclosed herein relate to the construction of fully-deleted Adenovirus-based gene delivery vectors packaged without helper Adenovirus, and more particularly to their use in gene therapy for gene and protein expression, vaccine development, and immunosuppressive therapy for allogeneic transplantation. In an embodiment, a method for propagating an adenoviral vector includes (a) providing an Adenovirus packaging cell line; (b) transfecting a fully-deleted Adenoviral vector construct into the cell line; and optionally (c) transfecting a packaging construct into the cell line, wherein the fully-deleted Adenoviral vector construct and optionally the packaging construct can transfect the Adenovirus packaging cell line resulting in the encapsidation of a fully-deleted Adenoviral vector independent of helper Adenovirus. In an embodiment, a target cell is transduced with the encapsidated fully-deleted Adenoviral vector for treating a condition, disease or a disorder.
US08871510B2 Methods for generating T lymphocytes from hematopoietic stem cells
This disclosure describes methods for differentiating T cells and NK cells in vitro from hematopoietic stem cells or precursor cells. The technology is directed to methods for the production of selected populations of lymphocytes, such as T cells and NK cells. The availability of such cell populations allows for the complete reconstitution of a depleted, defective or missing lymphocyte population in a patient.
US08871506B2 Methods for treating cardio pulmonary diseases with NO group compounds
The present invention relates to methods of treatment of pulmonary disorders associated with hypoxemia and/or smooth muscle constriction and/or inflammation; treatment of cardiac and blood disorders; treatment of patient in need of improved oxygenation, blood flow of and/or thinning of blood and method of screening drugs that increase level of nitrosoglutathione in airway lining fluid.
US08871505B2 Artificial skin
The present invention relates to a method for producing artificial skin, comprising: adding a matrix metalloproteinase inhibitor and a heparanase inhibitor to an artificial skin formation culture medium comprising human epidermal keratinocytes and human dermal fibroblasts, culturing the cells in the artificial skin formation culture medium, and forming artificial skin.
US08871503B2 Construct
A promoter for high level and sustained expression is provided which can be used for gene expression of chosen sequences in general. In particular, a nucleic acid construct comprising a hCEF1 promoter operably linked to a sequence for expression is provided, where the hCEF1 promoter comprises: (i) a human CMV enhancer operably linked to a human EF1 a promoter; (ii) a functional fragment of (i); or (ii) a functional variant of (i) or (ii).
US08871502B2 Culture medium device
The present invention discloses a culture medium device, which comprises a plate containing a solid-state or gel-state culture medium layer; a shield layer covering the culture medium layer; and a lid covering the plate. The shield layer is in a solid, gel or liquid state and contains sugar at a concentration of greater than 0% (w/w) and less than or equal to 0.1% (w/w). Via the shield layer containing a select composition, the present invention can reduce the affection of microbiological contamination and promote the yield and productivity of biomass in the process of inoculating and cultivating Polyporales.
US08871500B2 MEMS particle sorting actuator and method of manufacturing
A MEMS-based system and a method are described for separating a target particle from the remainder of a fluid stream. The system makes use of a unique, microfabricated movable structure formed on a substrate, which moves in a rotary fashion about one or more fixed points, which are all located on one side of the axis of motion. The movable structure is actuated by a separate force-generating apparatus, which is entirely separate from the movable structure formed on its substrate. This allows the movable structure to be entirely submerged in the sample fluid.
US08871499B2 Multi-well culture plate comprising gels with different shear modulus
A multi-well plate can be loaded with a range of compliant substrates. Commerically-available assays can be used to test cellular responses across a plate with shear modulus from 50 to 51200 Pascals. Cells can be grown in the plates, and can be manipulated and analyzed. Hydrogels can be attached to the bottom of a well. The plates can support the attachment and growth of different cell types and can be compatible with standard 96-well and 384-well plate assays. The mechanical properties of the hydrogels can be reproducible and stable to increase the shelf life of the substrate. The hydrogel can be compatible with growth of a variety of cell types, various attachment ligands such as collagen I, collagen IV, fibronectin, vitronectin, laminin, or RGD peptides and can be coupled to the gel surface.
US08871498B2 Device for measuring an ultra low gas flow
A measuring device is disclosed for measuring an ultra low gas flow, working by the principle of liquid displacement. In at least one embodiment, the measuring device includes at least one cell including a gas inflow device, a gas compartment device with a predefined inner geometric physical volume and active volume. In at least one embodiment, the gas compartment device includes one gas accumulating end and one lifting end, the gas compartment device also defining a geometric gas collecting point inside of the gas compartment device, during a gas filling cycle, the geometric gas collecting point moving further and further from the gas accumulating end to the lifting end during the gas filling cycle. Further, in at least one embodiment the cell includes a holding device having a pivoting element enabling the gas compartment device to pivot upwards when the geometric gas collecting point is positioned at the lifting end and the lifting force is larger than the down-pressing force at the lifting end, thereby releasing all of the accumulated gas in the gas compartment device, and then pivoting back to its initial standby position for new receipt and storage of gas during another gas filling cycle until next releasing sequence. Finally, in at least one embodiment, the cell also includes a sensor provided to generate a signal and/or change the state of a signal when the gas compartment device is not in its initial standby position, wherein the gas storing capacity of the inside of the gas compartment device is larger at the gas accumulating end than at the lifting end and wherein the gas accumulating end has a higher vertical position than the lifting end at the initial standby position.
US08871497B2 Device and method for automating microbiology processes
A device and method for automating the handling and testing of microbiological specimens are provided. A portable specimen collection vehicle (SCV) is provided which comprises a protective housing, a specimen chamber for receiving a biospecimen sample, a plurality of culturing chambers each for receiving a portion of the biospecimen sample and each containing a different culture medium, a system of fluid ducts connecting the specimen chamber to each of the culturing chambers, and an actuator that facilitates flow of portions of the biospecimen sample from the specimen chamber through the system of fluid ducts and into each of the culturing chambers, wherein biological organisms in the biospecimen begin to grow in one or more of the culturing chambers and cultured portions of the biospecimen sample can be withdrawn selectively from the apparatus.
US08871493B2 Transformation system in the field of filamentous fungal hosts
A novel transformation system in the field of filamentous fungal hosts for expressing and secreting heterologous proteins or polypeptides is described. The invention also covers a process for producing large amounts of polypeptide or protein in an economical manner. The system comprises a transformed or transfected fungal strain of the genus Chrysosporium, more particularly of Chrysosporium lucknowense and mutants or derivatives thereof. It also covers transformants containing Chrysosporium coding sequences, as well expression-regulating sequences of Chrysosporium genes. Also provided are novel fungal enzymes and their encoding sequences and expression-regulating sequences.
US08871492B2 Anti-dementia substance from Hericium erinaceum and method of extraction
A fat-soluble fraction extracted from the fruiting body of Hericium erinaceum is demonstrated to inhibit the neuronal toxicity of amyloid beta-peptide (Aβ) and induce the synthesis of nerve growth factor (NGF), and has great potential as an active ingredient for pharmaceutical products, health food products, food products and/or beverages to prevent and/or treat dementia, especially Alzheimer-type dementia. This invention is to provide the bioactive fraction and its preparation method.
US08871491B2 Capsular gram-positive bacteria bioconjugate vaccines
The present invention encompasses a novel S. aureus bioconjugate vaccine. More generally, the invention is directed to Gram-positive and other bioconjugate vaccines containing a protein carrier, at least one polysaccharide such as a capsular Gram-positive polysaccharide, and, optionally, an adjuvant or pharmaceutically acceptable carrier. The instant invention also includes methods of producing Gram-positive and other bioconjugate vaccines. An N-glycosylated protein is also provided that contains one or more polysaccharides such as Gram-positive polysaccharides. The invention is additionally directed to engineered prokaryotic organisms comprising nucleotide sequences encoding a glycosyltransferase of a first prokaryotic organism and a glycosyltransferase of a second prokaryotic organism. The invention further includes plasmids and prokaryotic cells transformed with plasmids encoding polysaccharides and enzymes which produce an N-glycosylated protein and/or bioconjugate vaccine. Further, the invention is directed to methods of inducing an immune response in a mammal comprising administering said bioconjugate vaccines.
US08871490B2 Alpha-4-beta-7 heterodimer specific antagonist antibody
There are disclosed alpha4beta7 heterodimer-specific antigen binding proteins, nucleic acids encoding them, and methods of making and using them.
US08871489B2 Metabolic evolution of Escherichia coli strains that produce organic acids
This invention relates to the metabolic evolution of a microbial organism previously optimized for producing an organic acid in commercially significant quantities under fermentative conditions using a hexose sugar as sole source of carbon in a minimal mineral medium. As a result of this metabolic evolution, the microbial organism acquires the ability to use pentose sugars derived from cellulosic materials for its growth while retaining the original growth kinetics, the rate of organic acid production and the ability to use hexose sugars as a source of carbon. This invention also discloses the genetic change in the microorganism that confers the ability to use both the hexose and pentose sugars simultaneously in the production of commercially significant quantities of organic acids.
US08871482B2 Bioprocessing
Functionalized substrate materials, for example inorganic particles and/or synthetic polymeric particles, are used to enhance bioprocesses such as saccharification and fermentation.
US08871479B2 Cellulase Cel5H related reagents and their use in microorganisms
The invention relates to applications of the cellulase Cel5H of Saccharophagus degradans and its homologues, functional fragments and/or variants and engineered forms thereof, in the context of recombinant, more particularly solventogenic microorganisms, more particularly C. acetobutylicum. The invention also characterizes a novel domain of the Cel5H cellulase with a putative cellulose-binding module function, and its uses in chimeric proteins for depolymerization of cellulose containing substrates.
US08871478B2 Coryneform bacterium transformant and process for producing isobutanol using the same
A Corynebacterium glutamicum transformant having the capability of producing isobutanol and the following genes (1) to (5): (1) a gene which encodes an enzyme having acetohydroxy acid synthase activity; (2) a gene which encodes an enzyme having acetohydroxy acid isomeroreductase activity; (3) a gene which encodes an enzyme having dihydroxy acid dehydratase activity; (4) a gene which encodes an enzyme having 2-keto acid decarboxylase activity; and (5) a gene which encodes an enzyme having alcohol dehydrogenase activity, at least one of the genes being endogenous, and at least one of the genes being exogenous, efficiently produces isobutanol.
US08871473B2 Method for producing γ-cyclodextrin by simultaneous use of γ-cyclodextrin glycosyltransferase and isoamylase
The present invention provides a method for the production of γ-CD, comprising making a starch slurry, incubating with γ-CGTase and isoamylase simultaneously for γ-CD production, forming a complex of γ-CD and an organic complexant, and purifying γ-CD from the complexant. The present invention provides a simple and cost-effective method for producing high purity γ-CD, which has a short production cycle, a high conversion rate, and is adaptable to large-scale industrial production.
US08871467B2 Polynucleotides encoding antibodies that bind both IL-17A and IL-17F
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. The present invention includes antibodies that bind both IL-17A and IL-17F, hybridomas that produce the antibodies, and methods of using the same in inflammation.
US08871465B2 Method for identifying bacteria from the Bacillus cereus group
The present invention relates to a method for identifying bacteria of the Bacillus cereus group, comprising the following steps: (a) providing a sample that may contain bacteria of the Bacillus cereus group, a reaction medium comprising at least one fluorescent phosphatidylcholine phospholipase C (PC-PLC) substrate and an inhibitor of Gram-negative bacteria; (b) inoculating the reaction medium with the sample; (c) incubating the inoculated reaction medium; and (d) identifying the bacteria of the Bacillus cereus group by detecting the PC-PLC substrate hydrolysis reaction, in which the pH of the reaction medium and the time necessary for detecting the PC-PLC substrate hydrolysis reaction are adapted such that said hydrolysis reaction by bacteria of the Bacillus cereus group is detected before hydrolysis of the PC-PLC substrate by any Gram-positive bacteria other than those belonging to the Bacillus cereus group, that may be present in the sample.
US08871461B2 Use of an in vitro hemodynamic endothelial/smooth muscle cell co-culture model to identify new therapeutic targets for vascular disease
Methods and devices for applying hemodynamic patterns to human/animal cells in culture are described. Hemodynamic flow patterns are measured directly from the human circulation and translated to a motor that controls the rotation of a cone. The cone is submerged in fluid (i.e., cell culture media) and brought into close proximity to the cells. Rotation of the cone creates time-varying shear stresses. This model closely mimics the physiological hemodynamic forces imparted on endothelial cells in vivo. A TRANSWELL coculture dish (i.e., a coculture dish comprising an artificial porous membrane) may be incorporated, permitting two, three, or more different cell types to be physically separated within the culture dish environment. In-flow and out-flow tubing may be used to supply media, drugs, etc. separately and independently to both the inner and outer chambers. The physical separation of the cell types permits each cell type to be separately isolated for analysis.
US08871453B2 Method of predicting acute appendicitis
Embodiments of the invention provide method and devices for predicting the likelihood of acute appendicitis without invasive exploratory medical procedures. Several protein biomarkers: leucine-rich α-2-glycoprotein (LRG); S100-A8 (calgranulin); α-1-acid glycoprotein 1 (ORM); plasminogen (PLG); mannan-binding lectin serine protease 2 (MASP2); zinc-α-2-glycoprotein (AZGP1); Apolipoprotein D (ApoD); and α-1-antichymotrypsin (SERPINA3); are increased in the urine of patients with appendicitis. The method and devices comprise detecting the levels of these biomarkers and comparing with reference levels found in healthy individuals.
US08871450B2 Biomarker for colorectal cancer
The present invention relates to new methods for predicting the clinical outcome or determining the treatment course in a subject afflicted with solid tumors, like colorectal cancer, and for monitoring the progression of solid tumors, like colorectal cancer, in a subject. Moreover, the present invention relates to a method for stratification of therapy regimen of a subject afflicted with solid tumor entities, such as colorectal cancer, for determining its susceptibility to the treatment with an inhibitor of angiogenesis. Further, the present invention relates to kits allowing performance of the above methods. In particular, the present invention is based on the finding that determining the level or amount of angiopoietin-2 protein in a sample of a subject is useful for conducting the above referenced methods.
US08871447B2 Immunogens and corresponding antibodies specific for high molecular weight aggregation intermediates common to amyloids formed from proteins of differing sequence
Compositions of matter that comprise one or more conformational epitopes found on amyloid peptide aggregates, antibodies to such epitopes and methods for making and using the compositions, eptitopes and/or antibodies. The invention includes synthetic or isolated compositions that contain or consist of certain conformational epitopes that are found on peptide aggregates (e.g., toxic peptide aggregates) present in human or veterinary patients who suffer from, or who are likely to develop, amyloid diseases (e.g., Alzheimer's Disease). The invention includes methods for the detection, treatment and prevention of diseases in humans or animals, using such compositions. The invention further includes antibodies which bind to the conformational epitopes as well as methods for making such antibodies and methods for the detection, treatment and prevention of diseases and/or identification of potential therapies (e.g., drug screening) using such antibodies.
US08871446B2 Microfluidic nucleic acid analysis
Nucleic acid from cells and viruses sampled from a variety of environments may purified and expressed utilizing microfluidic techniques. In accordance with one embodiment of the present invention, individual or small groups of cells or viruses may be isolated in microfluidic chambers by dilution, sorting, and/or segmentation. The isolated cells or viruses may be lysed directly in the microfluidic chamber, and the resulting nucleic acid purified by exposure to affinity beads. Subsequent elution of the purified nucleic acid may be followed by ligation and cell transformation, all within the same microfluidic chip. In one specific application, cell isolation, lysis, and nucleic acid purification may be performed utilizing a highly parallelized microfluidic architecture to construct gDNA and cDNA libraries.
US08871444B2 In vitro evolution in microfluidic systems
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalizing genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.
US08871442B2 Enhanced deposition of chromogens
This disclosure relates to compositions that enhance the deposition of detectable moieties on tissue samples, methods utilizing these compositions and kits including these compositions. The compositions include a deposition enhancer having a formula where R1, R2, R3, and R4 are independently selected from aliphatic, aryl, halogen, a heteroatom-containing moiety, and hydrogen; R1 and/or R3 can be bound to R2 to form a fused, aromatic ring system; R5 is selected from a heteroatom-containing moiety; A is selected from, a carbon atom, a heteroatom, other than sulfur, and any combination thereof; n is 1-5, an enzyme, a specific binding moiety and a detectable moiety.
US08871440B2 Method for evaluation of tissue preservation solution
The present invention provides a method for evaluating preservative effect of a tissue preservation solution, comprising immersing a mammalian tissue introduced with a luminescence or fluorescence labeling gene in the tissue preservation solution, measuring a luminescence or fluorescence level by the labeling gene in the tissue after immersion, and evaluating the preservative effect of the tissue preservation solution based on the luminescence or fluorescence level.
US08871438B2 Disease diagnosis method, marker screening method and marker using TOF-SIMS
The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/z) peaks of biological samples measured using a time-of-flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.
US08871426B2 Photoresist composition for color filter and method for forming color filter
A photoresist composition for a color filter is provided which includes a) a coloring agent, b) a binder resin, c) a photopolymerization initiator, d) a photopolymerizable monomer, and e) a solvent, wherein a siloxane-based material is bonded to the binder resin.
US08871424B2 Laser imageable polyolefin film
The presently disclosed subject matter is directed generally to a polymeric film that comprises at least one laser imageable marking layer. The marking layer comprises a polyolefin, a photochromatic pigment, and an additive. It has been surprisingly discovered that a polyolefin film comprising a marking layer formulated with a photochromatic pigment and an additive offers a substantial advantage over prior art methods of laser imaging polyolefin films.
US08871422B2 Negative-type photosensitive resin composition, pattern forming method and electronic parts
A negative-type photosensitive resin composition which is good in sensitivity and resolution, a pattern forming method by the use thereof wherein a pattern which can be developed in an alkali aqueous solution, is excellent in sensitivity, resolution and heat resistance and has a good shape is obtained, and highly reliable electronic parts are provided. The negative-type photosensitive rein composition includes (a) a polymer that has a phenolic hydroxyl group at a terminal and is soluble in the alkali aqueous solution, (b) a compound that generates an acid by irradiating active light, and (c) a compound that can be crosslinked or polymerized by an action of the acid.
US08871421B2 Positive resist composition and method of pattern formation with the same
A positive resist composition comprising: (A) a resin which comes to have an enhanced solubility in an alkaline developing solution by an action of an acid; (B) a compound which generates an acid upon irradiation with actinic rays or a radiation; (C) a fluorine-containing compound containing at least one group selected from the groups (x) to (z); and (F) a solvent, and a method of pattern formation with the composition: (x) an alkali-soluble group; (y) a group which decomposes by an action of an alkaline developing solution to enhance a solubility in an alkaline developing solution; and (z) a group which decomposes by an action of an acid.
US08871420B1 Method and system for magnetic actuated mixing to prepare latex emulsion
A method and system for magnetic actuated mixing which use magnetic particles and magnetic field to facilitate the mixing for preparing latex emulsion. In embodiments, a suitable process includes dissolving a resin in an organic solvent, optionally adding a surfactant, adding a neutralization agent and water, adding magnetic particles, and subjecting the mixture to a magnetic actuated mixing to form a latex emulsion. In embodiments, the latex emulsion thus produced may be utilized to form a toner.
US08871419B2 Production process of toner for electrostatic image development
The toner for electrostatic image development has excellent charge properties, by which excellent toner particle size-controlling ability is achieved, and moreover the sharpening of a particle size distribution is achieved. The toner is composed of toner particles containing a binder resin. The process has an aggregating step of adding an aggregating agent containing a transition element into an aqueous medium of dispersed fine binder resin particles to aggregate the fine binder resin particles, and an aggregation-stopping step of adding an aggregation stopper composed on a sulfur atom-containing compound exhibiting a reducing action on the aggregating agent. The aggregating agent is a salt of a bivalent or higher metal selected from Sr, Ti, V, Cr, Mn, Fe, Co, Ni and Cu.
US08871411B2 Method for manufacturing waveguide lens
A method for manufacturing a waveguide lens is provided. A planar waveguide is provided, wherein the planar waveguide includes a top surface and a side surface perpendicularly connecting with the top surface, the side surface is coupled to a laser light source, and the laser light source emits a laser beam having a divergent angle and an optical axis substantially perpendicular to the side surface. A media film grating is formed on the top surface. The media film grating is made of a high refractive index material. The media film grating includes a plurality of parallel media film strips, each of which is substantially perpendicular to the side surface. A pair of strip-shaped electrodes is formed on the top surface and is arranged at opposite sides of the media film grating and the optical axis. The pair of strip-shaped electrodes is substantially parallel to the media film strips.
US08871409B2 Lithographic targets for uniformity control
A photo mask having a first set of patterns and a second set of patterns is provided in which the first set of patterns correspond to a circuit pattern to be fabricated on a wafer, and the second set of patterns have dimensions such that the second set of patterns do not contribute to the circuit pattern that is produced using a lithography process based on the first set of patterns under a first exposure condition. The critical dimension distribution of the photo mask is determined based on the second set of patterns that do not contribute to the circuit pattern produced using the lithography process based on the first set of patterns under the first exposure condition.
US08871406B2 Highly proton conductive crosslinked vinylsulfonic acid polymer electrolyte composite membranes and its preparation method for polymer electrolyte fuel cells
A highly proton conductive polymer electrolyte composite membrane for a fuel cell is provided. The composite membrane includes crosslinked polyvinylsulfonic acid. The composite membrane is produced by impregnating a mixed solution of vinylsulfonic acid as a monomer, a hydroxyl group-containing bisacrylamide as a crosslinking agent and a photoinitiator or thermal initiator into a microporous polymer support, polymerizing the monomer, and simultaneously thermal-crosslinking or photo-crosslinking the polymer to form a chemically crosslinked polymer electrolyte membrane which is also physically crosslinked with the porous support. Further provided is a method for producing the composite membrane in a simple manner at low cost as well as a fuel cell using the composite membrane.
US08871400B2 Fuel cell system and method for operating fuel cell system
A fuel cell system of the present invention is a fuel cell system including a fuel cell and includes a medium circulation passage, a heat medium tank, a first circulator, a recovered water tank, a water circulation passage, a second circulator, a water purifier, a temperature detector, and a controller. The heat medium circulation passage and the water circulation passage are configured so as to realize heat exchange between a heat medium and water. The controller executes a circulation operation in which when the temperature detector detects a temperature lower than a first temperature capable of sterilizing microorganisms, the second circulator is caused to operate such that the temperature detected by the temperature detector becomes the first temperature or higher. The controller forbids the operation of the second circulator when the temperature detector detects a temperature equal to or higher than a second temperature that is lower than a temperature at which heat deterioration of the water purifier occurs.
US08871398B2 Solid oxide fuel cell
A power generator includes a hydrogen generator that generates hydrogen in response to water vapor. A solid oxide fuel cell is coupled to the hydrogen generator for receiving hydrogen and is coupled to a source of oxygen.
US08871396B2 CO2 separator for direct methanol fuel cell system
A CO2 separator for a direct methanol fuel cell (DMFC) includes a single-layered membrane or a multi-layered membrane. In addition, (i) the membrane has a plurality of diffusion channels extending from an inside of the membrane to an outside of the membrane facing the inside, and mean diameters of the diffusion channels on the outside of the membrane are at least three-times greater than mean diameters of the diffusion channels on the inside of the membrane; and (ii) the inside and the outside of the membrane, and inner surfaces of the diffusion channels are hydrophobic.
US08871392B2 Fuel cell system
A fuel cell system includes a hydrogen path for supplying odorant-added hydrogen to the fuel cell, an estimating unit to estimate the depositing of the odorant in the fuel cell, and control unit to heat the fuel cell up to a temperature at which at least part of the odorant deposited in the fuel cell evaporates when the depositing of the odorant is estimated.
US08871381B2 Secondary battery
A secondary battery includes an electrode assembly having a positive electrode plate, a negative electrode plate, and a separator interposed between the positive and negative electrode plates, a can having at least one groove portion on an inner surface thereof, the electrode assembly being inserted into the can through an opening of the can to face the inner surface of the can, a cap assembly configured to seal the opening of the can, and an insulation case positioned in the can between the electrode assembly and the cap assembly, the insulation case including at least one protruding portion inserted into the groove portion of the can.
US08871379B2 Screen-less anode design concepts for low cost lithium electrochemical cells for use in implantable medical device applications
A new cathode design having a first cathode active material of a relatively low energy density but of a relatively high rate capability contacted to one side of a current collector and a second cathode active material having a relatively high energy density but of a relatively low rate capability contacted to the opposite side thereof is described. A preferred cathode is: SVO/current collector/CFx with the CFx facing a lithium anode body devoid of a screen-type current collector. The lithium anode is either supported directly on the inner casing sidewall or is contacted to a relatively small strip of metal devoid of perforations and serving as an anode current collector electrically connected to the negative terminal.
US08871378B2 Secondary battery including a cap assembly having a protection circuit assembly
A secondary battery includes a bare cell including a can, an electrode assembly, and a cap assembly, wherein the cap assembly includes a protection circuit assembly.
US08871373B2 Electrical insulator for electrochemical cell
An insulation portion for an electrochemical cell having a plurality of slots into which bent electrode tabs are slid through during an assembly process of an electrochemical cell. A latch is disposed adjacent the slots and is movable from a resting position to a biased position to engage the electrode tabs. Attachment of the insulation portion to the electrochemical cell and bending of the electrode tabs can be robotically performed, such that controllers of an attachment device and bending device are in communication with each other.
US08871368B2 Perpendicular magnetic recording medium and process for manufacture thereof
A perpendicular magnetic recording medium with SNR improved by reducing noise due to an auxiliary recording layer so that a higher recording density can be achieved. The perpendicular magnetic recording medium 100 includes a base, at least a magnetic recording layer 122 having a granular structure in which a non-magnetic grain boundary portion is formed between crystal particles grown in a columnar shape; a non-magnetic split layer 124 disposed on the magnetic recording layer 122 and containing Ru and oxygen; and an auxiliary recording layer 126 that is disposed on the split layer 124 and that is magnetically approximately continuous in an in-plane direction of a main surface of the base 110.
US08871366B2 Corrosion resistant coating for copper substrate
A protecting coating for a copper substrate is disclosed. The coating comprises seed layer comprising titanium ions that forms an “alloy-like” structure with the copper substrate. The coating further comprises a first layer of carbon disposed on the seed layer comprising titanium ions. A second layer comprising titanium is disposed on the first layer of carbon, and a second layer of carbon is disposed on the second layer comprising titanium.
US08871361B2 Tetradentate platinum complexes
Novel phosphorescent tetradentate platinum (II) compounds comprising a twisted aryl group are provided. Also provided are novel phosphorescent tetradentate platinum (II) compounds comprising an imidazo[1,2-f]phenanthridine moiety. The compounds may be used in organic light emitting devices to provide improved device efficiency, line shape and lifetime.
US08871358B2 Process for producing high etch gains for electrolytic capacitor manufacturing
Anode foil, preferably aluminum anode foil, is etched using a process of treating the foil in an electrolyte bath composition comprising a sulfate and a halide, such as sodium chloride. The anode foil is etched in the electrolyte bath composition by passing a charge through the bath. The etched anode foil is suitable for use in an electrolytic capacitor.
US08871353B2 Film composition and method of making the same
Films including at least one layer of a blend of a cyclic olefin copolymer and a hydrocarbon wax are described. Particularly, films including 75.0 wt % to 99.9 wt % of a copolymer of a cyclic olefin monomer and an acyclic olefin and 0.1 wt % to 25.0 wt % of a hydrocarbon wax are described. Methods of making such films are also disclosed.
US08871352B2 Dendritic oxygen scavenging polymer
An oxygen-scavenging composition is provided that includes an oxygen-scavenging polymer and a catalyst. The oxygen-scavenging polymer, which in preferred embodiments is suitable for use in packaging articles, is a dendritic polymer having one or more oxygen-scavenging groups.
US08871351B2 Easy-open end
An easy-open end which is excellent from the standpoint of sanitation and environmental friendliness yet satisfying both the close adhesion and the scratch resistance despite of using a bisphenol A-free primer. The easy-open end has a polyester film applied, via a primer, onto the inner surface of the end of an aluminum base sheet forming a surface-treating layer that contains a zirconium compound and/or a titanium compound and an organic compound, wherein the primer contains a polyester resin that contains not less than 30% by weight of a carboxyl group-introduced polyester resin, and a phenol resin at a weight ratio of 50:50 to 85:15.
US08871343B2 Partial-discharge-resistant insulating varnish, insulated wire and method of making the same
A partial-discharge-resistant insulating varnish has a polyamide-imide enamel varnish and an organo-silica sol that are dispersed in a solvent. The solvent has 50 to 100% by weight of γ-butyrolactone. An insulated wire has a conductor, and a partial-discharge-resistant insulation coating film formed on the surface of the conductor. The partial-discharge-resistant insulation coating film is made of the partial-discharge-resistant insulating varnish.
US08871341B2 Polyolefins having one or more surfaces modified to improve adhesion of polyisocyanate functional adhesives thereto
This invention relates to the modification of polyolefin structures, parts or components, used in assemblies to enhance the bonding of polar adhesives to surface of the polyolefin structures. Disclosed herein are novel articles comprising polyolefin structures having one or more surfaces modified according to the invention. The polyolefin structures have one or more surfaces with an epoxy resin layer disposed directly on the surface and then disposed on the epoxy resin layer is a layer of one or more compounds, oligomers or prepolymers having reactive isocyanate groups. The invention is also a method for modifying one or more surfaces of a polyolefin structure by successively depositing on the surfaces an epoxy resin layer disposed and a layer of one or more compounds, oligomers or prepolymers having reactive isocyanate groups. Also disclosed are kits of the modified polyolefin structures and one or more of adhesives or coatings having polar reactive groups. Further disclosed are methods of bonding the modified polyolefin structures to other substrates by contacting adhesives having polar reactive groups with the modified surfaces and the other substrates with the adhesive disposed therebetween. Also disclosed are coating methods which comprise contacting one or more coatings comprising polar reactive groups with the modified surfaces of the polyolefin structure.
US08871338B2 Lattice-structures and constructs with designed thermal expansion coefficients
A thermal expansion-managed lattice structure having a plurality of unit cells each having flexure bearing-mounted tabs supported on a base and actuated by thermal expansion of an actuator having a thermal expansion coefficient greater than the base and arranged so that the tab is inwardly displaced into a base cavity. The flexure bearing-mounted tabs are connected to other flexure-bearing-mounted tabs of adjacent unit cells so that the adjacent unit cells are spaced from each other to accommodate thermal expansion of individual unit cells while maintaining a desired bulk thermal expansion coefficient of the lattice structure as a whole.
US08871337B2 Intermediate transfer member for transfer ink jet recording
There is provided an intermediate transfer member for transfer ink jet recording in which formation of cracks on its surface is suppressed and that has good transferability. The intermediate transfer member for transfer ink jet recording includes a surface layer, a buffer layer, and a compression layer, wherein the surface layer, the buffer layer, and the compression layer are formed in that order from the image-forming surface side, a compression modulus (E1) of the surface layer is 300 MPa or more and 10000 MPa or less, a compression modulus (E2) of the buffer layer is 0.5 MPa or more and 30.0 MPa or less, and E1, E2, and a compression modulus (E3) of the compression layer satisfy formula (1) below. (E1/10)>E2>E3  Formula (1)
US08871336B2 Coating layer with low-friction for vehicle component and method for producing the same
The present invention provides a low-friction coating layer for vehicle components comprising: a Ti layer on a surface of a base material; a TiN layer on the Ti layer surface; a TiAgN layer on the TiN layer surface; and an Ag layer transferred on the TiAgN layer surface, and a method for producing the same.
US08871333B2 Interlayer hot compaction
A process for the production of a polymeric article comprises: (a) forming a ply having successive layers, namely, (i) a first layer made up of strands of an oriented polymer material; (ii) a second layer of a polymeric material; (iii) a third layer made up of strands of an oriented polymeric material, wherein the second layer has a lower peak melting temperature that of the first and third layers; (b) subjecting the ply to conditions of time, temperature, and pressure sufficient to melt a proportion of the fits layer, to melt the second layer entirely, and to melt a proportion of the third layer, and to compact the ply; and (c) cooling the compacted ply. The resultant articles have good mechanical properties yet may be made at a lower compaction temperature than articles not employing the second layer, leading to a more controllable manufacturing process.
US08871332B2 Transparent fluorine-containing polymer
Disclosed is a fluorine-containing polymer obtained by polymerizing a 1,6-diene-type ether compound represented by formula [1] and, for example, a (meth)acrylic acid compound represented by formula [2]. The fluorine-containing polymer shows high transparency, has a high glass transition point, and is soluble in a solvent and therefore has moldability. In the case where a (meth)acrylic unit has a reactive substituent, by utilizing the crosslinking reaction thereof, a thin film having high solvent resistance can be produced. In formulae [1] and [2], R1 and R2 each independently represent a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, which may be substituted, R3 represents a hydrogen atom, a fluorine atom, or a methyl group, and R4 represents a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, which may be substituted, or an aromatic group having 5 to 10 ring members, which may be substituted.
US08871329B2 Toothed power transmission belt with cloth component thereon
A power transmission belt having a body with a length, an inside, and an outside. The body has a plurality of teeth formed on the inside of the body and spaced along the length of the body. The body has a first surface at the inside of the body defined at least in part by the teeth. A cloth component has a first side attached to the first surface and a second side exposed to engage a cooperating pulley. The cloth component has first fibers at the first side of the cloth component with a first performance characteristic and second fibers at the second side of the cloth component with a second performance characteristic. The first side of the cloth component has different properties than the second side of the cloth component by reason of the presence of the first and second fibers.
US08871328B2 Impact and vibration absorbing body-contacting medallions, methods of using and methods of making
The present disclosure relates to cushioning medallions, methods of making and methods of using, particularly cushioning medallions comprising a relatively low durometer viscoelastic polymer gel, for use in gloves or on the body.
US08871327B2 Camouflage structure capable of altering its appearance
A camouflage structure, capable of altering its appearance, comprises a camouflage graphic layer and a color-changing layer disposed on the camouflage graphic layer. Originally, the camouflage structure presents a first color state. After the color-changing layer changes the color by driving methods, the camouflage structure presents a second color state. For example, a transparent or semi-transparent color-changing layer able to reflect or emitting red light could be disposed on the woodland camouflage graphic layer, which allows for the overall appearance to change from the greenish woodland camouflage to the brownish desert camouflage. Alternatively, the camouflage structure could comprise a greenish camouflage graphic layer made of material with red-shift characteristics, which means the greenish camouflage graphic layer consists of different colors of chromic materials with reversible red-shift characteristics. The greenish camouflage graphic layer can be red-shifted by driving methods so as to present an appearance of brownish desert camouflage.
US08871325B1 Web assembly for making and maintaining a contour of a baseball or a softball glove
A web assembly can be used for making and maintaining a contour of a baseball or softball glove. The web assembly comprises a plurality of horizontal straps comprising a top strap and a bottom strap mechanically coupled to a plurality of vertical straps comprising a left strap and a right strap. A right durable strap and left durable strap are mechanically coupled to at least one horizontal strap where the at least one horizontal strap is further mechanically coupled to the right strap and the left strap. In this manner, a user can wrap the web assembly around the glove and affix the right durable strap to the left durable strap with a hook and loop fastener, and allowing for the straps to deform slightly to make and maintain the contour of the glove.
US08871323B2 Vacuum insulation member, refrigerator having vacuum insulation member, and method for fabricating vacuum insulation member
Disclosed are a vacuum insulation member, a refrigerator having a vacuum insulation member, and a method for fabricating a vacuum insulation member. The vacuum insulation member includes: an envelope having gas impermeability and having a certain decompressed space therein; a core formed as a structure for maintaining a certain shape and disposed at an inner side of the envelope to support the envelope; and a filler formed as powder having micro pores and filled at the inner side of the envelope. The use of a glass fiber core can be avoided, an internal vacuum degree can be easily maintained, and a life span can be lengthened.
US08871321B2 Flexible inlay strips and method of manufacturing the same
A method of fabricating an ornamental purfling strip which has sufficient flexibility to be placed within a curved configuration. The ornamental purfling strips are sufficiently flexible to be placed, as a single unit, in curved channels which require the strip to bend. The flexibility results from a laminated structure comprising a layer of binding material overlain by an ornamental layer, with an adhesive or bonding agent attaching the layers together. The ornamental layer comprises a plurality of precisely placed breaks along its length. The binding material retains the individual fragments of the ornamental layer in the strip, but because the binding material comprises a flexible material, the layer of binding material is sufficiently flexible to allow the purfling strip to flex longitudinally and transversely. The ornamental layer may comprise organic shell material or synthetic materials such as synthetic opal.
US08871319B2 Flexible barrier packaging derived from renewable resources
Disclosed herein are flexible barrier packages composed of materials that are substantially free of virgin, petroleum-based compounds. The flexible barrier packages contain a sealant that has a biobased content of at least about 85%. The sealant is laminated to an outer substrate that has a biobased content of at least about 95% via a tie layer that can further include an extruded substrate. The extruded substrate has a biobased content of at least about 85%. Ink optionally can be deposited on either side of the outer substrate, and the exterior surface of the outer substrate can further include a lacquer. A barrier material layer can be deposited or laminated between the first tie layer and the outer substrate. The flexible barrier packages of the invention are useful for enclosing a consumer product, for example, food, drink, wipes, shampoo, conditioner, skin lotion, shave lotion, liquid soap, bar soap, toothpaste, and detergent.
US08871318B2 Robust packaging laminate, method for manufacturing of the packaging laminate and packaging container produced therefrom
A packaging laminate comprising a core layer of paper or carton with through-going holes, openings or slits, a first layer of heat sealable thermoplastic material applied on the outermost side of the packaging laminate, a second layer of heat sealable thermoplastic material applied on the other, innermost side of the packaging laminate, one or more barrier layers applied between the core layer and the innermost thermoplastic layer, the thermoplastic material and barrier layers all being laminated to each other within the regions of said holes to form a membrane of barrier and thermoplastic material layers. A method for manufacturing of the packaging laminate and a packaging container that is made from the packaging laminate.
US08871313B2 Optical sheet
The present invention relates to an optical sheet for use in a liquid crystal display. The optical sheet of the present invention allows for ease of handling, reduces defective proportions and manufacturing costs, improves throughput, and prevents the deterioration of luminance attributable to the damage of the optical sheet.
US08871312B2 Method of reducing plasma arcing on surfaces of semiconductor processing apparatus components in a plasma processing chamber
Specialty ceramic materials which resist corrosion/erosion under semiconductor processing conditions which employ a corrosive/erosive plasma. The corrosive plasma may be a halogen-containing plasma. The specialty ceramic materials have been modified to provide a controlled electrical resistivity which suppresses plasma arcing potential.
US08871311B2 Curing method employing UV sources that emit differing ranges of UV radiation
Disclosed is a method providing efficient curing of an optical-fiber coating on a drawn glass fiber. The method employs one or more UV-radiation sources that emit electromagnetic radiation to effect the curing of coated glass fiber.
US08871310B2 Surface-modified tantalum oxide nanoparticles, preparation method thereof, and contrast medium for X-ray computed tomography and highly dielectric thin film using same
The present invention relates to a surface-modified tantalum oxide nanoparticle, a method for preparation thereof, a contrast agent (medium) for X-ray computed tomography, and a highly dielectric (high-κ) film using the same. In particular, the present invention is directed to a surface-modified tantalum oxide nanoparticle, a method for preparing surface-modified tantalum oxide nanoparticles, comprising: (i) adding an aqueous phase to an organic solvent which contains a surfactant, to prepare a water-in-oil microemulsion; (ii) introducing a tantalum precursor to said microemulsion; (iii) adding a surface-modifier having an organic silane group or phosphine group to a solution obtained at the step (ii); (iv) removing said organic solvent from a product obtained at the step (iii); and (v) separating surface-modified tantalum oxide nanoparticles from a mixture obtained at the step (iv), a contrast agent for X-ray computed tomography, and a highly dielectric (thin) film using the same.
US08871309B2 Off-white and gray autodeposition coatings
A method for coating a metal substrate with a white to off-white or gray colored autodeposited coating comprising water, polymeric resin, HF and pigment particles comprising a core of titanium dioxide, an intermediate zirconia and/or alumina layer, and an outer organic layer, optionally the particles are treated with an anionic surfactant.
US08871305B2 Methods for infusing one or more materials into nano-voids of nanoporous or nanostructured materials
A method of forming composite nanostructures using one or more nanomaterials. The method provides a nanostructure material having a surface region and one or more nano void regions within a first thickness in the surface region. The method subjects the surface region of the nanostructure material with a fluid. An external energy is applied to the fluid and/or the nanostructure material to drive in a portion of the fluid into one or more of the void regions and cause the one or more nano void regions to be substantially filled with the fluid and free from air gaps.
US08871302B2 Chemical vapor deposition of graphene on dielectrics
A method for synthesizing graphene films is disclosed. Monolayer or multilayer graphene can be directly grown on the dielectric materials. The method includes the following steps: disposing dielectric materials and metals in a reactor, introducing reaction gases into the reactor and decomposing the reaction gases by heating, thus directly depositing graphene films on the surfaces of the dielectrics. High crystalline quality and low-defect graphene films can be synthesized directly on dielectric materials, without the process of wet etching and transfer. The method opens up a more direct route to apply graphene on electronics, optoelectronics, and bio-medical devices.
US08871300B2 Method for making carbon nanotube based composite
A method for making a carbon nanotube based composite is provided. In the method, carriers, solution containing metal ions, and a carboxylic acid solution are mixed to form a mixed solution containing a complex compound. A reducing agent is added into the mixed solution. The metal ions are reduced to metal particles absorbed on the surface of the carriers. The carriers having the metal particles absorbed thereon are purified to obtain the carbon nanotube based composite.
US08871297B2 Method of applying a nanocrystalline coating to a gas turbine engine component
A method of applying a nanocrystalline coating to a gas turbine engine component is described. The method comprises the steps of applying an intermediate bond coat to at least a portion of the component, and then applying the nanocrystalline coating to at least the portion of the component overtop of the intermediate bond coat. The component may include, for example, a blade of which a dovetail portion of the blade root is protected by applying the intermediate bond coat and the nanocrystalline coating thereto.
US08871295B2 Method for separating high aspect ratio molecular structures
A method for moving high aspect ratio molecular structures (HARMS), which method comprises applying a force upon a dispersion comprising one or more bundled and individual HARM-structures, wherein the force moves the bundled and/or the individual HARM-structure based on one or more physical features and/or properties for substantially separating the bundled and individual HARM-structures from each other.
US08871293B2 Method for making touch panel
The present disclosure relates to a method for making touch panel. A substrate having a surface is provided. The substrate defines two areas: a touch-view area and a trace area. An adhesive layer is formed on the surface of the substrate. The adhesive layer on the trace area is solidified. A carbon nanotube layer is formed on the adhesive layer. The adhesive layer on the touch-view area is solidified. The carbon nanotube layer on the trace area is removed. At least one electrode and a conductive trace is formed.
US08871290B2 Method for producing alpharized rice and alpharized rice produced by the method
To provide a method for producing alpharized rice in which a soaking process does not need to be provided and a shape of rice grains is maintained.Means of SolutionSuch technical measure is taken that pressurized steam-boiling step in which raw material rice grains are steam-boiled with pressurized steam, a cooking step in which the rice grains after the pressurized steam-boiling step is alpharized, a high temperature drying step in which the rice grains after the alpharizing step are dried at high temperature, and a low temperature drying step in which the drying is performed at temperature lower than the high temperature drying step are sequentially provided without providing a soaking step, and an alpharized layer is formed on a surface of the rice grains by pressurized steam-boiling before the cooking step.
US08871287B2 Container for eggs, method and apparatus for arranging and stabilizing eggs in a container
A method for arranging eggs in a container. Eggs placed in receptacles of the container come to a resting orientation, by virtue of eh contouring of the receptacle, such that a long axis of the first egg is tilted toward a rear portion of the container at nearly uniform angles slightly offset from a vertical axis, and parallel side-to-side. Using features of the container, movement of eggs from their resting orientation, as well as twisting (spinning) about their long axes is resisted during marking, shipping or handling. The orienting of eggs in the receptacles or compartments thereof may be aided by use of an egg orienter. Tilting of the eggs may be facilitated by using receptacles or compartments which are asymmetrically contoured with respect to the vertical axis.
US08871285B2 Method for making a two component beverage and associated two compartment container
A method is provided for forming a two component beverage using a container having two compartments, an upper compartment and a lower compartment, each containing a beverage ingredient. The upper compartment contains a first beverage ingredient, such as powdered milk, and the lower compartment 8 contains a second beverage ingredient, such as instant coffee. The upper compartment can be stacked above the lower compartment such that access to the lower compartment is through the upper compartment.
US08871284B2 Method and compositions for preserving wine
Resveratrol and/or pterostilbene are added to wines to preserve the wine from oxidation, bacteria and fungi, as well as to deliver resveratrol to an animal. The resveratrol and/or pterostilbene are also added to red wine to preserve the polyphenols present in red wine. The resveratrol and/or pterostilbene can be added to grape must prior to fermentation and/or to fermented wine prior to bottling.
US08871282B2 Extract of Coptidis rhizoma and novel use thereof in treating respiratory disease
A composition for suppressing cough, removing sputum, preventing and/or treating a respiratory disease comprising an extract of Coptidis rhizoma or a combined extract of Coptidis rhizoma with ivy leaf as an active ingredient, and a method of suppressing cough, removing sputum, and/or preventing and/or treating respiratory disease using the composition, are provided.
US08871278B2 Stabilized hypohalous acid solutions
The present invention provides a stabilized hypohalous acid solution (or formulation thereof), which may be conveniently packaged for sale, or stored for later use on demand. The invention further provides methods of making the stabilized hypohalous acid solution, as well as methods of use for disinfecting mammalian tissue, including wounds and burns, disinfecting or cleansing surfaces, or treating and/or preserving food products and cut flowers, among other uses.
US08871277B2 Particulate wood preservative and method for producing the same
A wood preservative includes injectable particles comprising one or more sparingly soluble copper salts. The copper-based particles are sufficiently insoluble so as to not be easily removed by leaching but are sufficiently soluble to exhibit toxicity to primary organisms primarily responsible for the decay of the wood. Exemplary particles contain for example copper hydroxide, basic copper carbonate, copper carbonate, basic copper sulfates including particularly tribasic copper sulfate, basic copper nitrates, copper oxychlorides, copper borates, basic copper borates, and mixtures thereof. The particles typically have a size distribution in which at least 50% of particles have a diameter smaller than 0.25 μm, 0.2 μm, or 0.15 μm. At least about 20% and even more than 75% of the weight of the particles may be composed of the substantially crystalline copper salt. Wood or a wood product may be impregnated with copper based particles of the invention.
US08871276B2 Beta-casein assemblies for mucosal delivery of therapeutic bioactive agents
The present invention discloses a dried composition comprising β-casein micelles, assemblies and complexes thereof. The dried composition is stable in the dried state as well as upon re-suspension The dried composition retains the biological activity, drug load capacity, particle size and particle size distribution of the β-casein micelles, assemblies and complexes comprising the active pharmaceutical ingredient, within the dried state and upon resuspension in a buffer or an aqueous pharmaceutical carrier.
US08871269B2 Method for the preparation of controlled release formulations
The methods disclosed herein are of use for the production of controlled release compositions. In particular, the methods provide the contacting of an organic phase containing a bioactive agent and a polymer with an aqueous phase containing an organic ion to create controlled release compositions containing bioactive agents. The present invention also includes controlled release compositions including a polymer, an organic ion and a bioactive agent. The present invention also includes methods of using such controlled release compositions. The usefulness of the present invention is that the methods result in the production of controlled release compositions containing bioactive agent capable of administration in a concentrated low-dose form, having low burst and reduced production of degraded bioactive agent.
US08871268B2 Biodegradable polymeric networks and methods for manufacturing the same
Methods of manufacturing a three-dimensional, biodegradable, thermoset polymeric network composition having desirable degradation and mechanical properties, comprising a macromer component cross-linked with a monofunctional acrylate-containing component. The macromer component can comprise a diacrylate-containing component polymerized with an amine-containing component, wherein the molar ratio of the diacrylate-containing component to the amine-containing component is greater than or equal to 1.
US08871266B2 Probiotic storage and delivery
Probiotic microorganisms are micro encapsulated by dispersing the probiotic microorganism in an aqueous suspension of a film forming protein and a carbohydrate; in an oil in water emulsion of a film forming protein and a carbohydrate and a fat; or in an oil which is subsequently dispersed in a film forming protein and a carbohydrate. The emulsion or suspension may be dried to form a powder. The probiotic may be dispersed in oil and then emulsified with the aqueous suspension and then dried to produce an encapsulated oil be dried to produce a powder. Oil suspended probiotics may be preferred where the probiotic is water sensitive. The preferred protein is casein or whey protein and the carbohydrate may be a resistant starch or a saccharide with a reducing sugar group. Where the probiotic is oxygen sensitive the protein carbohydrate is heated to create Maillard reaction products in the encapsulating film.
US08871265B2 Pharmaceutical formulation containing gelling agent
Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together with one or more pharmaceutically acceptable excipients; the dosage form further including a gelling agent in an effective amount to impart a viscosity unsuitable for administration selected from the group consisting of parenteral and nasal administration to a solubilized mixture formed when the dosage form is crushed and mixed with from about 0.5 to about 10 ml of an aqueous liquid; the dosage form providing a therapeutic effect for at least about 12 hours when orally administered to a human patient.
US08871258B2 Treatment and prevention of learning and memory disorders
The present invention generally relates to compositions and methods for transdermal drug delivery, including treatment and prevention of learning and memory disorders, and enhancement of learning or memory. In some cases, the composition may include nitric oxide. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
US08871255B2 Treatment of skin and soft tissue infection with nitric oxide
The present invention generally relates to compositions and methods for treatment of skin and/or other soft tissues that are infected with bacteria such as Staphylococcus aureus, and/or other infectious organisms. In some cases, the composition may include nitric oxide. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., onto a site of infection, or on another suitable portion of the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
US08871254B2 Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
The present invention generally relates to compositions and methods for treatment of subjects having or at risk of acne or other conditions. In some cases, the composition may include nitric oxide. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., onto a location with acne, or on another suitable portion of the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
US08871253B2 Liposome having inner water phase containing sulfobutyl ether cyclodextrin salt
A liposome comprising bilayer and inner water phase is disclosed. Said inner water phase contains sulfobutyl ether cyclodextrin and active compound. Said sulfobutyl ether cyclodextrin is sulfobutyl ether α-cyclodextrin, sulfobutyl ether β-cyclodextrin, or sulfobutyl ether γ-cyclodextrin.
US08871252B2 pH-responsive liposome
The present invention provides pH-responsive liposomes which are capable of holding a desired substance in an acidic pH environment and releasing the desired substance in a basic pH environment.The present invention uses pH-responsive liposomes comprising, as constituent lipids thereof, a cationic amphiphilic molecule and at least one of an anionic amphiphilic molecule and a twitterionic amphiphilic molecule, wherein the liposomes, when dispersed in an aqueous medium, have a positive zeta potential in an acidic environment where the dispersion has a pH of less than 6.5 and have a negative zeta potential in a basic environment where the dispersion has a pH of 8.5 or more.
US08871249B2 Medicated patch
Provided is a medicated patch containing a medicinal agent, an adhesive base material and a tackifier, where the medicinal agent is varenicline or a pharmaceutically acceptable salt thereof, the adhesive base material is a rubbery adhesive base material and the tackifier is a rosin-based tackifier selected from the group consisting of rosin, rosin derivatives and hydrogenated products of the foregoing, or a non-rosin-based tackifier selected from the group consisting of aliphatic hydrocarbon resins and alicyclic hydrocarbon resins, and when a non-rosin-based tackifier is added as the tackifier, a solubilizer for the medicinal agent is further added, the solubilizer containing an alcohol-based solubilizer having at least a solubility parameter of 20-35.
US08871241B2 Injectable sustained release delivery devices
An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as “coatings,” “skins,” or “outer layers”). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles. The device may be formed by combining at least one polymer, at least one drug, and at least one liquid solvent to form a liquid suspension or solution wherein, upon injection, such suspension or solution under goes a phase change and forms a gel. The configuration may provide for controlled release of the drug(s) for an extended period.
US08871240B2 Rapamycin coated expandable devices
Medical devices may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including restenosis, vulnerable plaque, and atherosclerosis in type 2 diabetic patients.
US08871237B2 Medical scaffold, methods of fabrication and using thereof
Articles of manufacturing comprising electrospun elements having continuous or stepwise gradients of porosity, average pore size, weight per volume and/or of agents for promoting cell colonization, differentiation, extravasation and/or migration are provided. Also provided are methods of manufacturing and using same for guiding tissue regeneration.
US08871228B2 Injectable composition containing hydroxychloroquine for local administration for treating hemorrhoids
The present invention relates to an injectable composition for local administration for treating hemorrhoids, which contains hydroxychloroquine. Specifically, the composition contains a solution of hydroxychloroquine in physiological saline for injection, together with a local anesthetic and an antioxidant.
US08871226B2 Methods and compositions for the treatment and diagnosis of cancer
The invention provides methods of treatment of prion disease, cancers and other conditions, the methods comprising administration of an anti-Candida agent. Also disclosed are methods of diagnosing prion disease and cancers, said methods based on the determination of the presence of Candida infection, in particular systemic candidiasis.
US08871222B2 Recombinant Flavivirus vaccines
The invention provides recombinant flavivirus vaccines that can be used in the prevention and treatment of flavivirus infection. The vaccines of the invention contain recombinant flaviviruses including attenuating mutations.
US08871220B2 Newcastle disease virus vectored avian vaccines
The present invention encompasses engineered Newcastle Disease Virus (NDV) vaccines or compositions. The vaccine or composition may be a recombinant vaccine. The invention also encompasses recombinant vectors encoding and expressing avian pathogen antigens, more specifically avian influenza proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals, in particular avian, against disease.
US08871218B2 Infant nutritional compositions for preventing obesity
The present invention relates to a method for preventing obesity later in life by administering a certain nutritional composition to an infant between 0 and 36 months of age.
US08871200B2 Method for treating human diseases associated with an increased deoxyribonucleic acid content in extracellular spaces of tissues and a medicinal preparation for carrying out said method
The invention relates to medicine. The invention provides inventive method for treating human diseases associated with an increased deoxyribonucleic acid content in extracellular spaces of tissues and organs, which method comprises enterally administering DNAse enzyme in a quantity of 20 000-500 000 Kunz units in a day per 1 kg of the body mass. The single dose of the inventive medicinal preparation for treating human diseases associated with an increased deoxyribonucleic acid content in extracellular spaces of tissues and organs comprises 20 000-500 000 Kunz units of the DNAse enzyme. The oral administration of the above-mentioned important doses of the preparation allows the catalytically significant amount of DNAse to be absorbed into the systemic circulation in such a way that the dose-dependent treating effect thereof is exhibited.
US08871193B2 Viral vectors and their use in therapeutic methods
The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
US08871190B2 Polymeric pheromone formulation and method of use to calm stress-related behavior in mammals over an extended period of time
Pheromone compositions comprising a combination of squalene, linoleic acid and 1-docosanol are described, along with methods of using the pheromone compositions to modify behavior in mammals. The compositions are useful for behavior modification in mammals that exhibit undesirable or harmful stress-related behaviors.
US08871189B2 MMP-targeted therapeutic and/or diagnostic nanocarriers
The present invention provides targeted delivery compositions and methods of using the compositions for treating and diagnosing a disease state in a subject.
US08871187B2 Oxoazetidine derivatives, process for the preparation thereof and use thereon in human medicine and in cosmetics
Compounds derived from oxoazetidine corresponding to general formula (I) compositions containing same, processes for their preparation and their use in pharmaceutical or cosmetic compositions are described.
US08871186B2 Compositions and methods for control of malodor and other environmental contaminants
Nanocomposite compositions forming mixed clathrates and methods for using such compositions for entrapping guest moieties such as malodors, molds and cells are disclosed.
US08871183B2 Composition for promoting and maintaining oral health
A composition for improving oral health and methods of using and forming the composition are disclosed. The composition includes one or more active ingredients and a carrier. The composition is configured to maintain the active ingredient(s) with a surface of an oral cavity for an extended period of time to promote oral health and hygiene.
US08871182B2 3D nanocrystals and manufacturing methods
The invention relates to nanocrystals, containing one or more metals as defined in the specification; having a size of 2 to 200 nm; having a defined, three-dimensional polyhedral structure, optionally functionalized by ligands and/or embedded crystals. The invention further relates to monodisperse assemblies of such nanocrystals, to formulations and devices comprising such nanocrystals as well as to the manufacture and use thereof.
US08871180B2 Organic-inorganic hybrid particles containing contrast agent
This invention provides organic-inorganic hybrid particles containing as the essential components a block copolymer comprising an uncharged hydrophilic polymer chain segment and a polymer chain segment containing a repeated structural unit having a carboxylate ion group at its side chain; calcium ion (Ca2+), phosphate ion (PO43−) or carbonate ion (CO32−), or a mixture of these anions; and a contrast agent. The particles provide, in particular, carriers for stably delivering an MRI contrast agent to a target site.
US08871179B2 Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid
The present invention relates to novel modified fatty acid analogs, where a positron or gamma-emitting label is placed at a position on a fatty acid backbone and an organic substituent is substituted at the 2,3; 3,4; 4,5; 5,6 and other sequence positions of a fatty acid backbone. These novel fatty acid analogs are designed to enter the tissues of interest by the same long chain fatty acid carrier mechanism as natural fatty acids, however, functional substituents in the 2,3; 3,4; 4,5; 5,6 and other sequence positions, block the catabolic pathway, thus trapping these analogs in a virtually unmodified form in the tissues of interest.
US08871175B2 Nanomaterial having tunable infrared absorption characteristics and associated method of manufacture
A quantum nanomaterial having a bandgap that may be tuned to enable the quantum nanomaterial to detect IR radiation in selected regions including throughout the MWIR region and into the LWIR region is provided. The quantum nanomaterials may include tin telluride (SnTe) nanomaterials and/or lead tin telluride (PbxSn1-xTe) nanomaterials. Additionally, a method of manufacturing nanomaterial that is tunable for detecting IR radiation in selected regions, such as throughout the MWIR region and into the LWIR region, is also provided.
US08871172B2 Carbon fibers having improved strength and modulus and an associated method and apparatus for preparing same
The invention is directed to carbon fibers having high tensile strength and modulus of elasticity. The invention also provides a method and apparatus for making the carbon fibers. The method comprises advancing a precursor fiber through an oxidation oven wherein the fiber is subjected to controlled stretching in an oxidizing atmosphere in which tension loads are distributed amongst a plurality of passes through the oxidation oven, which permits higher cumulative stretches to be achieved. The method also includes subjecting the fiber to controlled stretching in two or more of the passes that is sufficient to cause the fiber to undergo one or more transitions in each of the two or more passes. The invention is also directed to an oxidation oven having a plurality of cooperating drive rolls in series that can be driven independently of each other so that the amount of stretch applied to the oven in each of the plurality of passes can be independently controlled.
US08871170B2 Polyhalite IMI process for KNO3 production
A process for producing KNO3 from polyhalite to is disclosed. In a preferred embodiment, the process comprises steps of (a) contacting polyhalite with HNO3; (b) adding Ca(OH)2 to the solution, thereby precipitating as CaSO4 at least part of the sulfate present in said solution; (c) precipitating as Mg(OH)2 at least part of the Mg2+ remaining in said solution by further addition of Ca(OH)2 to the remaining solution; (d) concentrating the solution, thereby precipitating as a sulfate compound at least part of the sulfate remaining in solution; (e) separating at least part of the NaCl from the solution remaining; and (f) crystallizing as solid KNO3 at least part of the K+ and NO3-contained in the solution. The process enables direct conversion of polyhalite to KNO3 of purity exceeding 98.5% and that is essentially free of magnesium and sulfate impurities.
US08871167B2 Biocompatible ceramic-polymer hybrids and calcium phosphate porous body
A hydroxyapatite ceramic hybrid material, which includes a biodegradable polymer included in the pores in a hydroxyapatite ceramic structure, and a method thereof, and a calcium phosphate porous body, which is formed by an intertwining of fibrous calcium phosphates and includes a plurality of first pores formed where the fibrous calcium phosphates interconnect and plurality of equal diameter substantially spherical second pores with a larger inside diameter than the first pores, and a method thereof are provided.
US08871160B2 Biomaterial detecting device
Provided is a biomaterial detecting device for confirming or detecting a biomaterial reaction, and more particularly to a biomaterial detecting device, which is formed in a stick type to thereby be immersed in a tube containing a biomaterial solution to be tested; has an upper portion with a cap structure to thereby induce reaction with a biomaterial, and thus facilitate confirmation and detection of the biomaterial; and is formed in a cap structure to thereby prevent evaporation of a sample and infiltration of an external material at the time of a biomaterial reaction in the tube, and thus improve reliability in analysis.
US08871158B2 Histology slide and paraffin block system
A protective sheath for prolonged storage of pathology paraffin blocks. The sheath protects the paraffin block against gouging, scratching, denting, rodents, and insects. A pathology slide slides into a slot in the protective sheath and is held into place by retainers running on the interior face of the protective sheath. A paraffin block cassette accepts a paraffin block and slides into a sample block sleeve holder disposed on one edge of the sheath.
US08871156B2 Fluid interface cartridge for a microfluidic chip
An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.
US08871151B2 Apparatus for mixing two streams of catalyst with an insert having aligned openings
An apparatus for mixing streams of regenerated and carbonized catalyst utilizes bend provided on only one of the catalyst conduits to provide mixing advantages. A pair of horizontally aligned openings with a band between the pair of openings provided a robust design and superb catalyst mixing performance.
US08871149B2 Modular gas chromatograph
This invention is related to a gas chromatograph wherein more substitutable modules are foreseen, in particular injector modules and/or detector modules, as well as one embodiment in an oven module. Each module is insertable in a seat of the gas chromatograph mainframe with fast connections of its electronic and pneumatic means to corresponding outlets on said mainframe. Each module has its own heating element.
US08871147B2 Sample analyzer and storage medium
A sample analyzer comprising: a measurement unit holds a reagent to be used in a sample measurement and measures a sample by using the reagent; a memory storing a usage amount of the reagent used by the measurement unit; a controller calculates an estimated usage amount of the reagent for a specific day, based on the usage amount of the reagent stored in the memory; and a display, wherein the controller controls the display to show a screen including graphic information illustrating a remaining amount of the reagent held by the measurement unit and the estimated usage amount of the reagent for the specific day, first numerical information indicating, by means of a numerical value, the remaining amount of the reagent, and second numerical information indicating an excess or shortage amount of the remaining amount of the reagent relative to the estimated usage amount of the reagent.
US08871138B2 Method and device for blow-molding containers
The invention relates to a method and a device for blow-molding containers. Following thermal conditioning inside a blow-mold of a blow-molding machine, a preform (1) is formed into the container (2) by means of blowing pressure. The necessary blow-molding gas (P1, P2) is provided by a supply device. The stored, pneumatic pressure energy inside the blown container is at least partially transformed into another form of energy.
US08871137B2 Process for producing medical instruments
A process for producing medical instruments (7) comprising the operations of extruding plastic material in order to obtain a heated tubular element (1) made of molten state plastic material, performing on the tubular element (1) a blow molding in order to obtain a plurality of medical containers (6). The process comprises the operation of calibrating the inner surface (6a) of the various medical containers (6), performed after the operation of extruding plastic material, in order to make smooth and continuous the inner surface (6a) of each of the medical containers (6).
US08871133B2 Method and composition for reducing waste in photo-imaging applications
Waste reduction, including hazardous waste reduction in photoimaging processes can be accomplished by improving diffusional resolution of cationic curable compositions. The addition of fluorinated polymers including fluorinated surfactants provides improved diffusional resolution in cationic and/or radical based photoimaging formulations allowing for image accuracy improvements, and reduced product and process waste quantity and disposal cost. These fluorinated surfactants also allow for increased cure speed, and non-hazardous constituent formulations that result in less wasted material and time.
US08871132B2 Methods for shaping green bodies and articles made by such methods
A method of shaping a green body provides a shaped green body comprised of a plurality of sinterable particles and an organic binder. Such a method includes: (1) molding a mixture of sinterable particles and organic binder into the shape of an initial green body or intermediate, wherein the sinterable particles include at least one of metal particles or ceramic particles; and (2) shaping the green body intermediate with at least one of a stream of energy or a stream of matter, wherein the shaping yields a green body having a desired shape. The shaped green body can be sintered in order to provide a hardened body having substantially the shape of the shaped green body.
US08871124B2 Method for producing a filament yarn from an aromatic polyamide
A method for producing a filament yarn from a para-aromatic polyamide, having an optically anisotropic aramid spinning solution filtered within a spinneret arrangement by using a filter having passage openings and extruded within the spinneret arrangement through a plurality of spinning orifices. The extruded anisotropic aramid spinning solution is guided via an air gap, stretched in the process, and collected in an aqueous coagulation bath. The optically anisotropic aramid spinning solution in the spinneret arrangement is fed to the spinning orifices via a flow resistor. The flow resistor is arranged closer to the spinning orifices than the filter, and the flow resistor and the filter are arranged at a distance to one another. The method may also include a para-aromatic polyamide filament yarn.
US08871120B2 Compositions of matter, and methods of removing silicon dioxide
Some embodiments include methods of removing silicon dioxide in which the silicon dioxide is exposed to a mixture that includes activated hydrogen and at least one primary, secondary, tertiary or quaternary ammonium halide. The mixture may also include one or more of thallium, BX3 and PQ3, where X and Q are halides. Some embodiments include methods of selectively etching undoped silicon dioxide relative to doped silicon dioxide, in which thallium is incorporated into the doped silicon dioxide prior to the etching. Some embodiments include compositions of matter containing silicon dioxide doped with thallium to a concentration of from about 1 weight % to about 10 weight %.
US08871115B2 Process of forming a luminescent material
A luminescent material can be formed by a process using a vacancy-filling agent that includes vacancy-filling atoms. In an embodiment, the process can include forming a mixture of a constituent corresponding to the luminescent material and the vacancy-filling agent. The process can further include forming the luminescent material from the mixture, wherein the luminescent material includes at least some of the vacancy-filling atoms from the vacancy-filling agent. In another embodiment, the process can include melting a constituent corresponding to the luminescent material to form a melt and adding a vacancy-filling agent into the melt. The process can also include forming the luminescent material from the melt, wherein the luminescent material includes at least some of the vacancy-filling atoms from the vacancy-filling agent. The luminescent material may have one or more improved performance properties as compared to a corresponding base material of the luminescent material.
US08871104B2 Method of forming pattern, reticle, and computer readable medium for storing program for forming pattern
A method of forming a pattern includes forming a plurality of target patterns, forming a plurality of pitch violating patterns that make contact with the plurality of target patterns and are disposed between the plurality of target patterns, classifying the plurality of pitch violating patterns into a first region and a second region adjacent to the first region, and forming an initial pattern corresponding to one of the first region and the second region.
US08871101B2 Liquid separator including venturi device
First and second liquids are separated from mixtures thereof in a holding tank that holds quantities of the two liquids after they have been separated and a quantity of the mixture that has not been separated. A first transfer conduit receives a pressurized mixture of the first and second liquids which is discharged into the holding tank. A venturi passageway is located in the first transfer conduit. A liquid conductor has an entry opening positioned so that at least a portion of the entry opening is located within the quantity of the mixture that is held in the holding tank and an exit opening that is in fluid communication with the venturi passageway. The increase in the velocity of the pressurized mixture flowing through the venturi passageway and the accompanying reduced pressure causes the mixture held in the holding tank to flow through the liquid conductor into the venturi passageway.
US08871097B2 Reclamation of formate brines
A method of reclaiming a formate brine may include increasing the pH of a spent formate brine fluid comprising water-soluble polymers; treating the fluid with an oxidizing agent; and removing at least a portion of suspended solids from the fluid. Further, a method of reclaiming a formate brine may include lowering the pH of the spent formate brine fluid comprising water-soluble polymers; increasing the pH of the spent formate brine fluid to initiate precipitation of materials solubilized in the fluid; treating the fluid with an oxidizing agent to break down remaining water-soluble polymer; and recovering at least a portion of the formate brine.
US08871095B2 Dialysis method including wireless patient data
A dialysis method comprising coding a wireless receiver of a dialysis machine with at least one of an address or a personal identification number (“PIN”); and receiving at least one of blood pressure data from a blood pressure monitor wirelessly or patient weight data from a weight scale wirelessly, wherein the at least one coded address or PIN ensures that the at least one of the blood pressure data or the patient weight data is received by the receiver as opposed to a receiver of another dialysis machine.
US08871094B2 Wastewater treatment facility and bioreactor for treating wastewater from oil and gas exploration and production
Volatile organic compounds (VOCs), such as BTEX methanol and other non-phase separable hydrocarbons may be removed from wastewater obtained from oil or gas exploration or production operations by way of a bioreactor. The bioreactor may employ anaerobic microorganisms that metabolize various VOCs. In some embodiments, such a bioreactor may be configured to treat process flow rates of thousands of barrels of wastewater per hour. Such a bioreactor may comprise a large vessel at a larger water treatment site.
US08871091B2 Filtration assembly including a body, a head, a cartridge and means for retaining the cartridge on the head and the body, and corresponding filtration cartridge
A filtration assembly is provided for a liquid flowing in an engine or hydraulic equipment, of the type including a body with a head on top thereof, and a cylindrical member for holding a filtration cartridge containing a filtration medium defined by an upper flange and a lower flange. The upper flange is coupled to the head by a first longitudinal retainer. The cartridge includes a second longitudinal retainer interacting with the body. The first retainer having a longitudinal tensile strength lower than the longitudinal tensile strength of the second retainer.
US08871087B2 Device and method for purifying water
A device and method for purifying waste water and stormwater flows by passage through a filter, which can be manufactured in various configurations. The filter has a broad range of thickness ranging from 1 mm to 20 meters. The filter is comprised of fibers from a melt of composition of 50% silicon dioxide, 15% aluminum oxide, 15% calcium oxide, 10% magnesium oxide, and other various oxides at lower percentages. At least the majority of fibers having a mean diameter of 4 microns and a mean length of 3 mm. The fiber solids of content of the material are at most 35% of the volume at a flow rate greater than 1 inch per hour to remove various pollutants from the water flow.
US08871085B2 Method and apparatus for programably treating water in a water cooler
An apparatus for a programmable self sanitizing water dispenser apparatus with a digital controller as well as a programmable method for generating ozone for cleaning the reservoir and the water contained within it. The apparatus includes an anti-spill receiver that houses the controller and that can contain a ozone generator.
US08871084B2 Fluid filter comprising a protected liquid sensor
The invention relates to a fluid filter (1) comprising a collecting chamber (10) for a liquid which is separated from the fluid, in addition to a filter insert (4) which comprises a filter medium which is permeable to the fluid. The collecting chamber is arranged below the filter medium (5), and a liquid sensor (19) is arranged above the deepest point of the collecting chamber (10) and the liquid sensor (19) is protected from the liquid, at least sectionally, by means of a protective wall (18, 20). Said protective wall (18, 20) extends laterally and/or below the liquid sensor (19) and a liquid permeable connection is provided from the collecting chamber (10) to the fluid sensor (19). The invention is characterized in that the permeable connection extends in a labyrinth like manner such that the fluid flowing through said connection changes direction a plurality of times, the liquid permeable connection allows the fluid to flow in a radial manner from the collecting chamber (10), which surrounds the protective wall, to the liquid sensor. Said liquid sensor is separated from the collecting chamber in the radial direction by at least two protective walls (18, 20), wherein in the radially internal protective wall, the closest to the liquid sensor, a through opening (25) which is as high as or higher than the liquid sensor (19) is provided, and a through opening (25) having the same height or higher than the liquid sensor is provided in at least one protective wall (18) which is arranged in a radial manner further to the outside.
US08871083B2 Methods and devices for extracting hydrocarbons from oil sand
A method and a device for carrying out the method for extracting hydrocarbons from oil sand uses organic extractants and a filter apparatus with a continuous rotary filter as well as a steaming unit.
US08871082B2 Process and apparatus for producing diesel from a hydrocarbon stream
A process and apparatus are disclosed for hydrotreating a hydrocarbon feed in a hydrotreating unit and hydrocracking a second hydrocarbon stream in a hydrocracking unit. The hydrocracking unit and the hydrotreating unit may share the same recycle gas compressor. A make-up hydrogen stream may also be compressed in the recycle gas compressor. A hydrocracking separator separates recycle gas and hydrocarbons from the hydrocracking unit to be processed with effluent from the hydrotreating unit.
US08871080B2 Management system for an electrolyte analyzer
Electrolyte analyzers are used in a variety of ways, and problems vary from reagent deterioration due to reagent replenishment, mixing of foreign substances during reagent replenishment, electrode deterioration due to the passage of the validity date, to the operator's inputting errors. It is thus necessary to judge abnormalities of measured values resulting from such inappropriate usage, based on the fluctuation patterns of the results of daily electrolyte calibration. The fluctuation patterns of each measured item are extracted from the results of daily electrolyte calibration. The electromotive force balance ratio between the internal standard solution and high/low-concentration standard solutions is calculated as well as its fluctuation pattern. The obtained fluctuation patterns are compared against atypical fluctuation patterns stored in the electrolyte analyzer. When any of the extracted patterns matches any of the atypical patterns, the analyzer activates an alarm.
US08871079B2 Voltammetric systems for assaying biological analytes
The present invention relates to systems, methods, and devices for determining the concentration of an analyte in a sample. The use of linear, cyclic, or acyclic voltammetric scans and/or semi-integral, derivative, or semi-derivative data treatment may provide for increased accuracy when determining the concentration of an analyte in a sample. Hematocrit compensation in combination with the data treatments may reduce the hematocrit effect with regard to a glucose analysis in whole blood.In another aspect, fast scan rates may reduce the hematocrit effect.
US08871078B2 Ruthenium or osmium complexes and their uses as catalysts for water oxidation
The present invention provides ruthenium or osmium complexes and their uses as a catalyst for catalytic water oxidation. Another aspect of the invention provides an electrode and photo-electrochemical cells for electrolysis of water molecules.
US08871077B2 Corrosion-resistant plating system
Methods of providing a corrosion-resistant plating on a steel bumper are provided. A galvanized zinc layer is deposited over a steel substrate. A plurality of nickel layers is deposited over the zinc layer. The plurality of zinc layers has at least a first porosity and a second porosity. A chrome layer is applied over the plurality of nickel layers. The porous nickel layer is immediately adjacent the chrome layer such that a stress applied to the chrome layer is distributed over the porous nickel layer. The porous nickel layer delocalizes a stress applied at an impact area to a dispersed area and the dispersed area is larger than the impact area.
US08871075B2 Method of forming metal pattern and method of manufacturing display substrate having the same
A method of forming a metal pattern includes forming a precursor layer including a metal precursor on a substrate, irradiating a light on the precursor layer to form a metal seed layer having a predetermined pattern, and electroless-plating the metal seed layer to form a metal pattern layer.
US08871071B2 Droplet manipulation device
Methods are provided for manipulating droplets. The methods include providing the droplet on a surface comprising an array of electrodes and a substantially co-planer array of reference elements, wherein the droplet is disposed on a first one of the electrodes, and the droplet at least partially overlaps a second one of the electrodes and an intervening one of the reference elements disposed between the first and second electrodes. The methods further include activating the first and second electrodes to spread at least a portion of the droplet across the second electrode and deactivating the first electrode to move the droplet from the first electrode to the second electrode.
US08871069B2 Low total salt reagent compositions and systems for biosensors
A biosensor system for determining the concentration of an analyte in a sample is disclosed that includes a reaction means for selectively performing a redox reaction of an analyte, and a measurement means for measuring a rate of the redox reaction of the analyte. The reaction means includes a binder, a buffer salt, a mediator including at most 20% (w/w) of an inorganic, non-transition metal salt, and an enzyme system. The measurement means includes at least two conductors. The measurement means measures an output signal value from the reaction means at a maximum kinetic performance within at most 7 seconds of introducing a sample to the reaction means, where the output signal value is responsive to the concentration of the analyte in the sample, and the measurement means determines at least one ΔS value responsive to at least one error parameter. The measurement means further determines the analyte concentration in the sample from a compensation equation including at least one reference correlation and the at least one ΔS value, where the compensation equation has a R2 value of at least 0.5.
US08871068B2 Continuous monitor sensor with covalently bound enzyme
The disclosure concerns a high efficiency electrochemical sensor with high signal yield for determining an analyte in a fluid medium comprising, at least one reference electrode, at least one working electrode having particles of an electrocatalyst in an electrode matrix, and an enzyme that is suitable for determining an analyte is selectively covalently bound to the particles of the electrocatalyst. The disclosure also describes a process for producing the electrochemical sensor and a method for determining an analyte in a fluid medium using the electrochemical sensor. have a high efficiency and thus achieve a high signal yield.
US08871065B2 Equipment for the surface treatment of parts by immersion in a processing liquid
The invention relates to an equipment for the surface treatment of parts (4), that comprises a plurality of treatment vats arranged in series and comprising rotating drums (2) provided with means for temporarily attaching the parts to be processed and having their axes (XX′) rotatingly mounted horizontally so that the major portion of each drum (2) is submerged in the processing liquid contained in the corresponding vat, and a conveyor line (14) for supplying each drum (2) with parts to be processed and for removing from said drum the parts already processed, characterized in that the conveying process is carried out along a general axis (ZZ′), and in that the axes (XX′) of the drums are parallel relative to each other and parallel to the general axis (ZZ′) of the conveyor line.
US08871063B2 Process for selective removal of a product from a gaseous system
A process for selective removal of a gaseous product (P) from a gaseous system comprising said product and other components (R1, R2), wherein the gaseous system is admitted to a first environment, which is separated from a second environment by a boundary wall, and a permeation membrane (3, 300) forms at least part of said boundary wall; a spatially non-uniform electric field (4) is generated between a first electrode or first plurality of electrodes (1, 301) located in the first environment and a second electrode or second plurality of electrodes (2, 302) located in the second environment, so that field lines of said non-uniform electric field cross said membrane, and a dielectrophoretic force generated on particles of said gaseous component (P) is at least part of a driving force of the permeation through said membrane, an amount of said product (P) being selectively removed from the first environment and collected in the second environment.
US08871058B2 Addition of endothermic fire retardants to provide near neutral pH pulp fiber webs
A process in which an at least partially delignified pulp fiber web having a Kappa number of less than about 130 is treated with an aqueous endothermic fire retardant solution having a pH of about 10 or less. The treated pulp fiber web has a near neutral pH of from about 5 to about 9, and is treated with at least about 20 lbs of endothermic fire retardants per ton of the pulp fiber web, with at least about 5% of the total amount of endothermic fire retardants being added at a point prior to when the pulp fiber web is formed. Also a fire resistant pulp fiber web having a near neutral pH.
US08871053B2 Fire retardant treated fluff pulp web
A fire resistant fluff pulp web made from a fluff pulp web, a fire retardant component present in and/or on the fluff pulp, and a fire retardant distributing surfactant which distributes the fire retardant component in and/or on the fluff pulp web in a manner so that the fluff pulp web passes one or more fire resistance tests. Also, a process for preparing these fire resistant fluff pulp webs, as well as for treating outer fibrous layers comprising an air-laid mixture of these fire resistant fluff pulp fibers and bicomponent fibers with up to about 5% additional fire retardant and which are used in fire resistant air-laid fibrous structures useful in upholstery, cushions, mattress ticking, panel fabric, padding, bedding, insulation, materials for parts in devices and appliances, etc.
US08871052B2 Processes to produce short cut microfibers
A process for separating a first mother liquor stream is provided. The process comprises: separating a first mother liquor stream in a second solid liquid separation zone to produce a secondary wet cake stream and a second mother liquor stream; wherein the first mother liquor stream comprises water non-dispersible microfiber, water, and water dispersible sulfopolyester; wherein the second mother liquor stream comprises water and water dispersible sulfopolyester; and wherein the secondary wet cake stream comprises water non-dispersible polymer microfiber.
US08871046B2 Transparent antiballistic article and method for its preparation
The invention relates to a method for the preparation of a transparent antiballistic article. The method comprises providing a plurality of anisotropic polymeric film layers, stacking the film layers to form an assembly and compressing the thus formed assembly at a temperature and pressure sufficient to consolidate the film layers, whereby the temperature is not more than 50° C. below the melting temperature of the polymer, the pressure is at least 80 MPa and sufficiently high to obtain an optical transparency according of at least 50% transmission. The invention also relates to a ballistic resistant article having an energy absorption for 17 grain FSP according to the STANAG 2920 standard of at least 10 J/(kg/m2) and an optical transparency according of at least 50% transmission.
US08871044B2 Part based on C/C composite material, and a method of fabricating it
After making a carbon fiber preform and prior to completing densification of the preform with a carbon matrix, impregnation is performed with a liquid formed of a sol-gel type solution and/or a colloidal suspension enabling one or more zirconium compounds to be dispersed. The impregnation and the subsequent treatment, up to obtaining the final part, are performed in such a manner as to have, in the final part, grains or crystallites of one or more zirconium compounds presenting a fraction by weight lying in the range 1% to 10% and of composition having at least a majority of the ZrOxCy type with 1≦x≦2 and 0≦y≦1.
US08871043B2 Masking method using masking jig
A masking jig holding unit (31) holds a masking jig, a robot moves the masking jig to place on a temporary placement table, an object holding unit (21) holds an object, the robot moves and positions the object to face an application unit (35b) in a predetermined position and posture, the application unit applies an adhesive to a masking part of the object, the robot directs the masking part of the object downward, and moves the object to the temporary placement table, and the robot brings the object down to the masking jig that is placed on the temporary placement table, and pastes the masking jig to the masking part of the object.
US08871042B2 Heat treatment apparatus and a method of using such apparatus
A heat treatment apparatus 10 for heat treating metals or metallic components includes a fluidized bed furnace 20 and a removable insert 30 which is accommodated within the fluidized bed 50 of the furnace 20. The removable insert 30 enables the geometry of the fluidized bed 50 to be optimized with respect to the size and shape of a component 70 which is to be heated.
US08871041B2 Copper alloy plate and method for producing same
A sheet material of a copper alloy has a chemical composition including 1.2 to 5.0 wt % of titanium, and the balance being copper and unavoidable impurities, the material having a mean crystal grain size of 5 to 25 μm and (maximum crystal grain size−minimum crystal grain size)/(mean crystal grain size) being 0.20 or less, and the material having a crystal orientation satisfying I{420}/I0{420}>1.0, assuming that the intensities of X-ray diffraction on the {420} crystal plane of the surface of the material and the standard powder of pure copper are I{420} and I0{420}, respectively.
US08871040B2 High ballistic strength martensitic armour steel alloy
The invention relates to an air hardenable high-hardness steel for armoring applications, such as armor plate for use in light armored vehicles and body armor, and having a high level of ballistic performance relative to its plate thickness. In particular, the invention concerns a high ballistic strength martensitic armor steel which, in an air cooled and untempered condition, has a strength coefficient (s0) of higher than 2500 MPa; a flow parameter (P) of higher than 8.0, preferably higher than 18.0; and a manganese content of 1.8 to 3.6% by weight of manganese, preferably 2.8 to 3.1% by weight of manganese. The armor steel also includes retained austenite at a volume fraction of at least 1%, and preferably a volume fraction of 4 to 20%.
US08871035B2 Process for the production of grain-oriented magnetic sheet starting from thin slab
A process for producing grain oriented magnetic sheets by subjecting a steel slab ≦100 mm, containing 2.5-3.5% si, to the following operations: optional first heating, to a temperature T1≦1250° C.; first rough hot-rolling at T2 between 900 and 1200° C., the reduction ratio (% Rid) being at least 80% in the absence of a subsequent heating or, in the presence of a subsequent heating to T3≦1300° C., at least 60% determined by % Rid=80−(T3−T2)/5; second finishing hot-rolling at T4<1300° C. to a rolled-section thickness of 1.5 3.0 mm; cold-rolling, in one or more stages with optional intermediate annealing and with a cold reduction ratio ≧60% applied in the last stage; primary recrystallization annealing, optionally in a decarburizing atmosphere; second recrystallization annealing.
US08871029B1 Shoe cleaning device and method
A shoe cleaning device is disclosed, mainly comprising a scrubber member and an enclosure. The scrubber member is provided with a handle and retention members to which disinfecting sanitary wipes can be attached, so that a user holding the scrubber member by the handle can use the scrubber member and attached sanitary wipe to efficiently remove soil and contamination from a shoe without soaking the shoe. The enclosure that has an internal space for storing a plurality of sanitary wipes, and an upper separation platform on top of which there is a recess for storing the scrubber member. The enclosure further includes a lid that closes onto the scrubber member and conceals the scrubber member, except for, optionally, the scrubber member handle. The lid preferably closes in a sealed manner to guarantee that the plurality of wipes does not dry out over time.
US08871024B2 High pressure apparatus and method for nitride crystal growth
An improved high pressure apparatus and methods for processing supercritical fluids is described. The apparatus includes a capsule, a heater, and at least one ceramic ring contained by a metal sleeve. The apparatus is capable of accessing pressures and temperatures of 0.2-2 GPa and 400-1200° C.
US08871015B2 Non-aqueous pigment dispersions using dispersion synergists
Non-aqueous pigment dispersions exhibiting improved dispersion quality and/or stability were prepared for a specific selection of naphthol AS pigments, diketopyrrolo-pyrrole pigments and quinacridone pigments, by using specific yellow monoazo dispersion synergists. The non-aqueous pigment dispersions can be advantageously used in inkjet inks inkjet printing methods.
US08871010B2 Plasma spray method for the manufacture of an ion conductive membrane
A plasma spray method for the manufacture of an ion conductive membrane is provided which ion conductive membrane has an ion conductivity, in which method the membrane is deposited as a layer (11) onto a substrate (10) in a process chamber, wherein a starting material (P) is sprayed onto a surface of the substrate (10) in the form of a process beam (2) by means of a process gas (G), wherein the starting material is injected into a plasma at a low process pressure, which is at most 10,000 Pa, and is partially or completely molten there. Oxygen (O2; 22) is supplied to the process chamber (12) during the spraying at a flow rate which amounts to at least 1%, preferably at least 2%, of the overall flow rate of the process gas.
US08871006B2 Solid mineral composition, method for preparing same and use thereof for reducing heavy metals in flue gas
The invention relates to a solid mineral composition of heavy metals, in particular mercury, in flue gas, to a method for preparing such a solid mineral compound and to the use thereof for reducing heavy metals, in particular mercury, in flue gas, by placing the flue gas in contact with the solid mineral composition.
US08871005B2 Methods of regenerating desiccant in a breathing apparatus
A method of regenerating a desiccant in a breather communicating with a vessel includes creating a temperature signal that is a temperature associated with at least one of the vessel and the breather for a plurality of cycles, each cycle having a predetermined duration, and regenerating the desiccant when the second derivative of the temperature signal reaches a peak value.
US08871004B2 Methods for agglomerating ores
A method for making an agglomerate of an ore is disclosed. The method comprises contacting the ore with an acid solution and a stucco binder. The stucco binder may include calcium sulfate hemihydrate. The ore agglomerate may include ore, acid solution, and stucco-derived gypsum.
US08871001B2 Method for leaching zinc from a zinc ore
A method for leaching zinc from a zinc-bearing carbonate ore, the method comprising the steps of: subjecting the zinc-bearing carbonate ore to elevated temperatures of between about 300° C. and about 900° C. thereby producing a roasted ore; subjecting the roasted ore to an aqueous acid or alkali leach thereby producing an aqueous zinc solution; and subjecting the aqueous zinc solution to a zinc recovery step.
US08870996B2 Mineral complex, compositions thereof, and methods of using the same
The invention provides inter alia a mineral complex comprising about 40 wt. % to about 60 wt. % SiO2, about 6 wt. % to about 16 wt. % Fe2O3, about 4 wt. % to about 12 wt. %. CaO, about 2 wt. % to about 8 wt. % MgO, wherein at least 85% of the mineral complex has a particle size of about 10 to about 6000 mesh, related compositions and methods for their use, including for growth medium augmentation and remediation.
US08870991B2 Natural gas production filtration vessel and assembly
A filtration device that includes a pressure vessel having an inlet and an outlet, the filtration device configured to filter a pressurized fluid stream. In an embodiment, the filtration device has at least one disk-shaped filter element housed within the pressure vessel arranged to filter fluid flowing from the inlet to the outlet, and an inlet flow tube disposed within the pressure vessel proximate the inlet tube, wherein the inlet flow tube is configured to direct the pressurized fluid stream from the inlet tube towards a central portion of the at least one disk-shaped filter element.
US08870987B2 Failure detecting apparatus for particulate filter
An object of the present invention is to detect any breakdown or failure of a particulate filter more appropriately. A failure detecting apparatus for detecting failure of a particulate filter according to the present invention comprises an acquiring section which acquires an amount of PM contained in an exhaust gas allowed to outflow from the particulate filter; a regeneration process executing section which executes a filter regeneration process for oxidizing and removing PM deposited in the particulate filter; and a failure judging section which judges that the particulate filter is in the failure state if a decreased amount of the amount of PM contained in the exhaust gas acquired by the acquiring section, during a predetermined period of time as started from a point in time at which the execution of the filter regeneration process performed by the regeneration process executing section is completed, is not equal to or larger than a predetermined reference amount.
US08870986B2 Bonded abrasive body and method of forming same
An abrasive article including a bonded abrasive body having abrasive particles contained within a bond material, the bond material including a vitreous material formed from a mixture having aluminum oxide (Al2O3), bismuth oxide (Bi2O3), and boron oxide (B2O3), and wherein the mixture includes an amount (wt %) of aluminum oxide less than an amount (wt %) of bismuth oxide and the amount (wt %) of aluminum oxide is less than an amount (wt %) of boron oxide.
US08870982B2 Method for converting biomass into products containing acetal groups and use thereof as biofuels
The invention describes a method of converting biomass to products that can be incorporated into the diesel fuel pool, comprising a first stage of fermentation of renewable raw materials of vegetable origin at the end of which a least one alcohol and at least one compound containing a carbonyl group are obtained, and a second stage corresponding to an acetalization reaction involving said alcohol and said compound containing a carbonyl group.
US08870975B2 Method of fabricating structured particles composed of silicon or a silicon-based material and their use in lithium rechargeable batteries
Pillared particles of silicon or silicon-comprising material and a method of fabricating the same are disclosed. These particles may be used to create both a composite anode structure with a polymer binder, a conductive additive and a metal foil current collector, and an electrode structure. The structure of the particles overcomes the problems of charge/discharge capacity loss.
US08870969B2 Prosthesis for a lower limb
A prosthesis for a lower limb includes an element for receiving a thigh stump fitted on a support part, a leg assembled on the support part by a pivot link forming a knee joint to enable flexion or extension of the leg with respect to the element for receiving, and an absorbing system to absorb the flexion or extension efforts. The absorbing system is fitted on the one hand on the pin of the pivot link and on the other hand on a first end of a rocker pivotally mounted on the leg, and a rod is fitted on the one hand on a second end of the rocker and on the other hand on the support part.
US08870957B2 Implant for mammalian bony segment stabilization
Embodiments of bony region stabilization implants including multiple fenestrations and bony ingrowth materials are described generally herein. Other embodiments may be described and claimed.
US08870949B2 Transcatheter heart valve with micro-anchors
Methods and devices for treating defective heart valves are disclosed herein. In one exemplary embodiment, a transcatheter heart valve includes an expandable shape memory stent and a valve member supported by the stent. A plurality of micro-anchors can be disposed along an outer surface of the stent for engaging native tissue. The transcatheter heart valve can be configured to be advanced into a dilated valve annulus via a balloon catheter. The balloon can be inflated to expand the transcatheter heart valve from a collapsed diameter to an over-expanded diameter such that the micro-anchors engage tissue along the surrounding valve annulus. After engaging the tissue, the balloon can be deflated and the shape memory stent can retract or recoil toward its predetermined recoil diameter. As the stent recoils, the surrounding tissue is pulled inward by the stent such that the diameter of the valve annulus is reduced.
US08870943B2 Stent structure for implantable medical device
A stent (30) is formed of a plurality of stent rings (24), each of which rings (24) is formed of a series of sprung sections (10) coupled to one another by flexible couplings (22). The flexible couplings (22) may be made of a biodegradable material. The flexible couplings (22) enable the stent (30) to expand to a smaller uncompressed diameter and then to expand further to a larger uncompressed diameter, by virtue of the flexible couplings (22) which allow the sprung sections to move from a partially overlapping configuration to a radially spaced configuration. The stent (30) can expand with expansion of a vessel, for example in a growing patient.
US08870939B2 Prosthesis having pivoting fenestration
The present disclosure relates to an endoluminal prosthesis, such as a stent graft that includes one or more fenestrations to accommodate endovascular disease, such as an aneurysm in cases where one or more side branches is involved. In one aspect, the prosthesis includes fenestrations that are pivotable to accommodate the dynamic geometry of the aortic branches. In another aspect, the pivotable fenestrations include a first perimeter, a band of flexible material attached and surrounding the first perimeter, and a second perimeter attached to and surrounding the band of flexible material. The first perimeter, band of flexible material, and second perimeter have a geometric shape. In one aspect, the prosthesis includes at least three pivotable fenestrations.
US08870937B2 Method for vessel access closure
Embodiments are described for closing vascular access ports, such as arteriotomies, which involve placement and deployment of an expandable device configured to prevent blood flow across a subject arteriotomy while also keeping disturbance of intravascular flow to a minimum. Suitable prostheses may comprise one or more frames constructed from lengths of flexible materials, such as shape memory alloys or polymers. Such frames may be coupled to sheetlike or tube-like structures configured to spread loads, minimize thrombosis which may be related to intravascular flow, and maintain hemostasis.
US08870933B2 Implant, implantation device, implantation method
An implant suitable for being anchored with the aid of mechanical vibration in an opening provided in bone tissue. The implant is compressible in the direction of a compression axis under local enlargement of a distance between a peripheral implant surface and the compression axis. The implant includes a coupling-in face which serves for coupling a compressing force and the mechanical vibrations into the implant, which coupling-in face is not parallel to the compression axis. The implant also includes a thermoplastic material which, in areas of the local distance enlargement, forms at least a part of the peripheral surface of the implant.
US08870929B2 Surgical devices for the correction of spinal deformities
A method for installing a surgical device on a spine for applying corrective forces thereon comprises installing at least one anchor on a first vertebra and at least another anchor on a second vertebra. At least one connector is installed on at least one of the first and the second vertebrae. A flexible tether is fixed to one of the anchors. The flexible tether is tensioned about a surface of the at least one connector. The flexible tether is fixed to the other one of the anchors to maintain a tension in the flexible tether to apply corrective forces to the vertebrae interconnected by the tether. A method for installing a staple device with rotational joints in the vertebrae is also provided.
US08870927B2 Bone anchoring device
A bone anchoring device includes an anchoring element having a head, a receiving portion having a first region adjacent to a second end for receiving the head and a recess which is open towards a first end to form two free legs for receiving a rod. The anchoring device further includes a pressure element configured to couple to the head, a first closure element and a second closure element. The first closure element cooperates with the legs to simultaneously fix the rod in the recess and fix the head in the receiving portion, and the second closure element cooperates with the legs, the second closure element acts on the pressure element and on the rod to independently fix the head in the receiving portion and fix the rod in the recess. The first closure element and the second closure element are interchangeable.
US08870925B2 Dynamic clamping device for spinal implant
A Spinal column implant for elastic stabilization of vertebrae includes an elastic rod that is anchored in a non-positive fit fashion in the receptacle of a pedicle screws by means of a mobile filling piece and a clamping element. The non-positive fit is supported additionally by a dynamic form-fit contribution upon exposure to load.
US08870921B2 Spinal cross connectors
Various methods and devices are provided for connecting spinal fixation elements, such as spinal rods, implanted in a patient's spinal column. In particular, various spinal cross connectors are provided for connecting to one or more spinal fixation elements implanted in a patient's spine. The cross connectors can have a variety of configurations, including a fixed or adjustable length, as well as various features that allow certain portions of the cross connectors to be angularly oriented.
US08870920B2 Devices and methods for inter-vertebral orthopedic device placement
Disclosed are devices and methods for the controlled movement of neighboring vertebrae and the delivery of an orthopedic implant between adjacent spinous processes. The methods are especially adapted to be performed using minimally invasive surgery or in a percutaneous manner. An exemplary method comprises advancing a first segment of a threaded first distraction screw into a bony surface of a spinous process of the first vertebral bone, coupling a first segment of a second distraction screw onto a segment of a second vertebral bone, positioning an orthopedic implant at a desired target site, and removing one of the first and second distraction screws.
US08870903B2 Blood sampling device
A device for sampling and/or analyzing blood or other body fluid of a subject. A housing contains a plurality of lancets and optionally includes test elements to take up a sample of blood, an evaluation system and a display. A complete system that can be handled as a single device, for example in the form of a wristwatch, includes a multiplicity of test elements and lancets, which can be brought successively to a working position to perform multiple measurements. A cassette or carrier includes multiple lancets and/or test elements, for insertion into the device.
US08870899B2 Self-assembling magnetic anastomosis device having an exoskeleton
The invention is an implantable magnetic anastomosis device having an exoskeleton that directs self-assembly. The design allows the device to be delivered in a linear configuration using a minimally-invasive technique, such as endoscopy or laparoscopy, whereupon the device self-assembles into, e.g., a polygon. A coupled set of polygons define a circumscribed tissue that can be perforated, or the tissue can be allowed to naturally necrose and perforate. The device can be used to create anastomoses in a variety of tissues, such as tissues found in the gastrointestinal, renal/urinary, and reproductive tracts. New procedures for using anastomoses, e.g., surgical bypass are also disclosed.
US08870897B2 Method and device for suture removal
A method for manipulating a suture is provided. The method includes providing support to tissue using a snare of a suture manipulation device and ensnaring, using the snare and without moving the snare, a portion of the suture when the portion of the suture passes through the tissue and is released by a needle. The method further includes securing, while removing the support to the tissue, the portion of the suture with the snare. The method further still includes removing the snare with the portion of the suture from the tissue.
US08870894B2 Surgical tissue retrieval instrument and method of use of a surgical tissue retrieval instrument
A surgical tissue retrieval instrument has a collapsible pouch at the distal end of an elongated pusher rod that is introduced into a patient through a cannula. The instrument includes a two-jaw fork that forms a loop when in an unconstrained configuration and that supports the pouch. Deployment and operation of the fork and the pouch are controlled by a securing mechanism. The two jaws and the securing mechanism are slid in a hem surrounding the opening of the pouch when the device is assembled.
US08870893B2 Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
Sinusitis, enlarged nasal turbinates, tumors, infections, hearing disorders, allergic conditions, facial fractures and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies, endoscopic studies and transillumination studies. Access and occluder devices may be used to establish fluid tight seals in the anterior or posterior nasal cavities/nasopharynx and to facilitate insertion of working devices (e.g., scopes, guidewires, catheters, tissue cutting or remodeling devices, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting devices, substance delivery implants, etc.
US08870890B2 Pronged holder for treating spinal stenosis
A device for holding a surgical instrument having a body, an instrument engagement device and a knob. The body has a proximal end, a distal end and a passageway positioned through the body. The instrument engagement device is positioned in the passageway and has at least two prongs moveable relative to each other to hold the surgical instrument therebetween. The knob is preferably positioned on the proximal end of the body and operatively associated with the at least two prongs so that movement of the knob causes movement of the prongs. The prongs may further include at least one ridge for engaging at least one slot on the surgical instrument. The knob may further comprise a cap at its proximal end positioned and designed for impact, for example, by a hammer, to facilitate movement of the surgical instrument into the patient. The knob may also include a locking mechanism to fix the position of the prongs.
US08870886B2 Straight cup impactor
An orthopedic impactor device for positioning an orthopedic prosthetic cup implant during a hip replacement surgery is described. The impactor is designed with a “one piece” elongated body portion, having a distal prosthetic cup engagement portion which is separated from a proximal strike plate by an elongated body and handle portions. A connection rod, connectable to an orthopedic prosthetic cup, is positioned longitudinally within the through-bores of the body and handle portions. A lever arm, having a linkage member, is pivotally connected to the rod such that when the lever arm is pivoted towards the exterior surface of the annular sidewall of the handle portion, the distal end of the rod moves within the body portion.
US08870884B2 Method for repairing bone defects
A method for repairing a soft tissue or bone defect can include selecting one of a plurality of sizing guides having a base perimeter size corresponding to a size of the defect, where each base has a different perimeter size and a plurality of apertures spaced apart a predetermined distance from each other, with the predetermined distance being the same for each of the sizing guides. The selected sizing guide base can be positioned against a distal end of the femur relative to the defect. A plurality of guide wires can be positioned through the plurality of apertures in the sizing guide base and the guide wires can be fixed to the femur such that the guide wires are parallel to each other. A first guide can be positioned over the guide wires and against the distal end of the femur to guide a first cutting member relative to the femur.
US08870882B2 Apparatus and method of spinal implant and fusion
An apparatus and method of performing a minimally invasive posterior spine fusion. More specifically an apparatus with a handle and a forked head on the distal end of the handle is used to grasp implant material and introduce the material to an implant site. The shaft of the apparatus is shaped so as to allow the affixation of a drill guide and drill while simultaneously holding the implant material in the implant site. After removal of the boring tools and assembly of the fusing element, the apparatus can be selectively removed from the implant site. A method of achieving facet joint fusion with near simultaneous fixation is also disclosed.
US08870881B2 Spinal correction system and method
A surgical instrument comprises a first member having a first surface defining a first cavity for disposal of a first implant. A distal end is configured to mate with a recess of a connector and defines a second cavity. A second member is configured for movable disposal in the second cavity. A third member is connected to the proximal end of the second member and the first implant. The second member is axially movable in a first direction to tension the first implant and in a second direction to release tension from the first implant. Methods of use are disclosed.
US08870880B2 Angling inserter tool for expandable vertebral implant
The present invention relates to a method of inserting an implant comprising providing an expandable vertebral implant. The method further may comprise providing an angling inserter tool. The angling inserter tool comprises a handle portion, a base portion, and a tip assembly, the base portion being disposed between the handle portion and the tip assembly. The method further may comprise distally advancing a central shaft of the tip assembly with rotation into an opening in the expandable vertebral implant to secure the angling inserter tool to the expandable vertebral implant. The method further may comprise positioning the expandable vertebral implant in a patient's spine. The method further may comprise for causing the tip assembly to angulate with respect to a longitudinal axis of the angling inserter tool, wherein the internal shaft is coaxial with an outer cylinder of the base portion.
US08870878B2 Minimally invasive retractor and methods of use
A device, system and method for orthopedic spine surgery using a novel screw-based retractor, disclosed herein, that allows for access to the spine through a minimally or less invasive approach. The retractor device is designed as a co-molded part of the tulip of a pedicle screw assembly with opposed arms of the retractor spread apart to open the wound proximally. The arms are removed by separating the arms from the tulip and removing them from the incision. The retractor device is intended to be made of a relatively stiff material, sterile packaged and disposable after one use. A system and method for using the retractor and performing a minimally invasive spine surgical procedure are also disclosed.
US08870877B2 Graft fixation device
A graft fixation device comprising a sheath having a body that defines an inner longitudinal bore and a member for insertion within the bore. The sheath includes at least two projections movably connected to the sheath body by a distal hinge. The distal hinge causes the projection to pivot inwardly as the sheath is placed in a bone tunnel, and to be displaceable radially outwardly of the sheath body upon insertion of the member within the bore.
US08870876B2 Methods and devices for treating hallux valgus
The various embodiments disclosed herein relate to implantable devices for the treatment of hallux valgus. More specifically, the various embodiments include devices having dynamic tensioning components or heat shrinkable components configured to urge two metatarsals together to treat a bone deformity.
US08870870B2 Vertebral fixing system
A vertebral fixing system comprising a connecting part with two longitudinal elements coupled to each other at a first end and having mutually facing recesses for receiving a rod. A portion of a flexible ligature extends through orifices of the two longitudinal elements to define a loop opposite two free ends of the flexible ligature. The two longitudinal elements are engaged at a second end of the connecting part via a locking means. When the two longitudinal elements of the connecting part are locked at the second end of the connecting part, two strands of the flexible ligature are pinched between the rod and a wall of the mutually facing recesses of the two longitudinal elements of the connecting part, preventing the flexible ligature from moving in translation relative to the connecting part.
US08870866B2 Electrosurgical system with suction control apparatus, system and method
System and method for selectively applying electrical energy to structures within or on the surface of a patient's body and controlling the flow of an electrically conductive fluid from the application site to provide or maintain a desired operating condition of the electrosurgical device. An electrosurgical probe is in communication with a fluid transport apparatus through a fluid transport lumen having an opening at an end proximate the application site and disposed proximate the electrosurgical probe. A controller in communication with the fluid transport apparatus provides control signals to the fluid transport apparatus in response to at least one operating parameter associated with the system. Based on the received control signals, the fluid transport apparatus adjusts a flow rate of the electrically conductive fluid at the application site through the fluid transport lumen in response to at least one operating parameter associated with the system.
US08870854B2 Release device for detaching a medical implant from an insertion device and an insertion device comprising a release device
A release device (100) and an insertion device (110) having such a release device (100) for detaching a medical implant from an insertion device (110), in which the implant can be released by way of a relative movement between a first and a second insertion element (52, 54), including a body (10) having a proximal end (12), which faces a user in the usage state, and a distal end (14), which is furthest away from a user in the usage state, wherein a spindle (10a) including at least two speed regions is provided between the proximal end and distal end (14), wherein the spindle (10a) is provided so as to generate a deliberate to relative movement between the first and second insertion elements (52, 54) of the insertion device (110).
US08870853B2 Operating a portable medical device
Some embodiments of a portable medical device, such as an infusion pump, can receive an external reference signal (e.g., a radio, cellular and/or satellite signal) to provide an automatic time-setting and maintenance operation. In these circumstances, the medical device can maintain accurate time and date information even in the event of a power interruption, a time-zone change and/or an internal clock error, for example. In this manner, the portable medical device provides safe operation and added convenience to the user.
US08870850B2 Medical connector
A valve for selectively permitting a fluid flow between first and second medical implements is disclosed. The valve has a housing with an interface suitable for receiving a connector portion of a first medical device such as a catheter, and a seal made of a flexible material. The seal has a first end in fluid communication with the interface, a second end suitable for receiving the second medical device, and at least one slit in fluid communication with the first end and the second end. The slit defines a restricted fluid flow path and a relatively small interior volume when in an undisturbed state, defines an expanded fluid flow path and a larger interior volume upon the introduction of the second medical instrument into the slit, and retracts to define a restricted flow path and a small interior volume upon the withdrawal of the second medical device from the seal.
US08870840B2 Protective diapering system
A protective diapering system is provided for the prevention of migration and introduction of stool with a male's genital area. The protective diapering system including a diaper having an anterior flap, a posterior flap, and a fenestrated flap disposed between the anterior and posterior flaps.
US08870835B2 Needle safety device for medical devices
A needle safety device for a medical device, in particular for an IV catheter assembly, being movably arranged on the needle comprising: a first part made of a suitable plastic material; a second part preferably made of a strip of suitable metal sheet; and a ring surrounding the first part and the second part having elastic properties made of suitable elastomeric material.
US08870831B2 Dose reset mechanism
A dose reset mechanism for a medicament delivery device with a housing and a medicament container includes a dose setting member in the housing for setting a dose when it is rotated and for resetting the dose when it is rotated in the opposite direction. The dose setting member has a drive member connected to a plunger rod such that when the drive member rotates, the rod moves axially; and a connection member between the dose setting member and the drive member. A ratchet mechanism enables the connection member to rotate when the dose setting member rotates for setting a dose but not to move in the opposite direction. At least one dose reset member and at least one blocking member are connected to the ratchet mechanism such that the connection member and drive member are released when a dose knob is turned in the opposite direction.
US08870829B2 Fluid infusion device and related sealing assembly for a needleless fluid reservoir
Disclosed herein is a fluid infusion device of the type that delivers medication fluid to the body of a patient. The device includes or cooperates with a fluid reservoir, and the device has a sealing assembly to receive and form a fluid seal with the fluid reservoir. A retractable sealing element surrounding a hollow fluid delivery needle may be used to seal a port of the fluid reservoir. The port may include a pressure vent that is sealed by the retractable sealing element. In one variation, the reservoir includes a moving valve sleeve that holds a septum. The septum moves to allow the reservoir to vent, and to form a seal with the port when the needle pierces the septum. In another variation, the device includes a needleless sealing assembly. In yet other variations, the device uses a needled fluid reservoir.
US08870828B2 Phlebotomy needle assembly and frangible cover
Medical needle assemblies incorporating a needle cover are provided. According to one aspect, the needle cover is integrally formed from a material that: (1) is sufficiently rigid to prevent bending of an underlying cannula, (2) is suitable for allowing a frangible portion thereof to be broken under pre-selected conditions, and/or (3) has a moisture vapor transmission rate sufficient for steam sterilization of a needle tip enclosed by the needle cover. According to another aspect, at least part of a cap portion and a hub portion of the needle cover are translucent. According to yet another aspect, the needle cover is provided with a wing having an enlarged rib suitable for gripping during separation of a cap portion from the remainder of the needle cover.
US08870827B2 Automatic injector
An automatic injector dispenses a predetermined dose of medicament without a user having to manually force the needle into an injection site. The automatic injector includes a needle cover having a locked retracted position with respect to the injector housing prior to a medicament dispensing operation. The needle cover is operative to engage an injection site prior to a medicament dispensing operation.
US08870826B2 Combined otic aspirator and medication dispenser
A device for making an incision in the tympanic membrane, withdrawing fluid from the tympanic cavity and administering a medicament to the space behind the tympanic membrane is provided. The device has a barrel-shaped casing (1) having a rotatable end turret (38). A first trigger (2) allows a shaft (18) to pierce the tympanic membrane and a tubular vacuum cartridge (32). The cartridge allows aspiration of fluid. A second trigger (4) causes medicament (34) to be released into the space behind the tympanic membrane.
US08870823B2 Stimulation of penis erection
A penis erection stimulation system comprises an infusion device (11) adapted for implantation inside the patient's body and at least one reservoir (R1, R2) adapted for implantation inside the patient's body in fluid connection with the infusion device to supply to the infusion device a substance to be injected into the patient's body. The reservoir comprises at least one first compartment accommodating or adapted to accommodate a first substance and at least one second compartment accommodating or adapted to accommodate a second substance, said second substance being a drug for stimulating penis erection. The infusion device preferably comprises one or more infusion needles disposed within and implanted along with one or more housings adjacent the patient's left and right corpora cavernosa. A pump may be implanted inside the patient's body to supply the infusion needle with infusion liquid. A drive unit also adapted for implantation inside the patient's body may be arranged for advancing and retracting the tip end of the infusion needle such that it penetrates the housing at least in two different penetration areas either simultaneously or in immediate time succession, thereby injecting drugs along with the infusion liquid into the patient's body for stimulating penis erection.
US08870817B2 Methods of using an adjustable variable stiffness medical device
A transluminal device may include an elongate section extending between a proximal end and a distal end of the device. The elongate section may be configured to be inserted into a body cavity. The device may include a balloon within the elongate section between the proximal end and the distal end.
US08870816B2 Device for treating hardened lesions
A balloon catheter is provided that may be used to dilate hardened regions of a stenosis on a vessel wall. The balloon catheter is provided with cutting elements that extend along a surface of a balloon. At least one bioactive is present, either on the cutting element, within the interior of the balloon, within the material of the balloon or on an outside surface of the balloon. The bioactive is delivered to the vessel wall upon dilation of the balloon.
US08870815B2 Steering system and a catcher system
A steering system (30) comprises two radially oppositely arranged drive wheels (1; 3) for steering a tubular object (5) positioned between the drive wheels (1; 3). The drive wheels (1; 3) each have a wheel rotation axis (40; 42) and each include a plurality of rollers (7) distributed around the wheel rotation axis (40; 42). The rollers (7) are rotatably arranged, each roller having a roller rotation axis (44) and an outer drive face (58) concavely vaulted in a direction corresponding to its roller rotation axis (44). The roller rotation axis (44) is obliquely oriented in relation to the wheel rotation axis (40; 42) and the rollers (7) of each drive wheel (1; 3) form together a steering periphery for the tubular object (5). The steering system enables continues rotation of a tubular object without danger that the object will lose the contact with the rollers. The steering system (30) may be incorporated in a catheter system which comprises a catheter (5).
US08870807B2 Gastro-intestinal compression device
Devices, methods, and systems for treating Type-2 Diabetes and/or obesity by facilitating the delivery of under-digested nutrients within the gastro-intestinal tract without substantial tissue removal are disclosed. In one aspect, the gastro-intestinal tract of a patient is modified by a gastro-intestinal treatment device comprising an elongate element configured to extend within the gastro-intestinal tract, a first attachment element and a second attachment element disposed on the elongate element, wherein the first attachment element and the second attachment element are configured to attach to the gastro-intestinal tract such that a portion of the gastro-intestinal tract is compressed between the first and the second attachment elements. The length of the gastro-intestinal tract modified by the device is effectively shortened, and its surface area is reduced.
US08870806B2 Methods of treatment using a bariatric sleeve
Method and apparatus for limiting absorption of food products in specific parts of the digestive system is presented. A gastrointestinal implant device is anchored in the stomach and extends beyond the ligament of Treitz. All food exiting the stomach is funneled through the device. The gastrointestinal device includes an anchor for anchoring the device to the stomach and a flexible sleeve to limit absorption of nutrients in the duodenum. The anchor is collapsible for endoscopic delivery and removal.
US08870802B1 Traction splint
A fraction splint for providing treatment to a broken or damaged lower extremity which includes a segmented-pole, an ankle assembly having a pad, strap, and retaining assembly, wherein the ankle assembly is retained inwardly of the foot, a groin assembly having a pad, strap, and tensioning assembly extending away from the ankle assembly, and a plurality of cravat straps. The ankle assembly has a curved back plate with upper and lower recesses to permit space for ankle prominences and a double-socket and closed-ended retaining cap for receiving a folded or non-folded end of the segmented-pole. The tensioning assembly includes a back plate, an open-ended intermediary socket, an adjustment assembly, and a retaining cap having a closed-ended socket for receiving the opposite end of the pole. The adjustment assembly is used to move the upper retaining cap towards or away from the back plate to apply traction to the attached leg.
US08870794B2 Devices and methods for cervix measurement
A device for measuring a length of a cervix includes an elongate measurement member extending along a longitudinal axis and including a measurement scale thereon, a hollow member coaxial with and disposed over the elongate measurement member, a flange offset from the longitudinal axis and attached to a distal end of the hollow member, a handle attached to a proximal end of the measurement member, and a locking mechanism on the handle. The hollow member is freely rotatable about the longitudinal axis relative to the measurement member to place the flange in a first position and in a second position perpendicular to the first position without moving the measurement scale. The locking mechanism is configured, when locked, to fix the hollow member relative to the measurement member and, when unlocked, to allow the hollow member to slide axially along the measurement member in the first and second positions.
US08870787B2 Ventricular shunt system and method
A ventricular shunt systems and methods of preventing hydrocephalus are described herein. In one aspect, the ventricular shunt system has at least one pressure sensor that is configured to be selectively electromagnetically coupled to an ex-vivo source of RF energy and is variable in response to the pressure in a patient's ventricle.
US08870786B2 Method and apparatus for tinnitus evaluation
Methods, articles of manufacture, and systems for evaluating tinnitus are disclosed herein. According to various embodiments, a tinnitus evaluation system may include a tinnitus evaluation module configured to perform one or more tinnitus evaluation tests. A tinnitus evaluation test may comprise generating a first single-frequency sound based at least in part on a sound of a patient's tinnitus, and generating a narrow-band sound centered at the frequency of the first single-frequency sound. Tests include a hearing threshold test, a loudness match test, a pitch match test, a bandwidth match test, a minimum masking level test, and a residual inhibition test.
US08870785B2 Contactless respiration monitoring of a patient
Respiration of a patient is detected by emitting an electromagnetic signal towards the patient; receiving a reflected electromagnetic signal reflected from the patient; converting the reflected electromagnetic signal, yielding a first signal; phase-shifting the reflected electromagnetic signal and converting the phase-shifted reflected electromagnetic signal, yielding a second signal; determining a first vector being defined by the time derivatives of the first signal and the second signal, for a common first point in time; determining a second vector being defined by the time derivatives of the first signal and the second signal, for a common second point in time; and calculating the scalar product of the normalized first vector and the normalized second vector as an indicator value for a change from expiration to inspiration of the patient or vice versa. A change from expiration to inspiration of the patient or vice versa is preferably indicated if the indicator value is below a threshold value, preferably below a value of 0. In this way, respiration is monitored contactlessly and remotely based on the Doppler radar principle which is reliable and easy to handle.
US08870783B2 Pulse rate determination using Gaussian kernel smoothing of multiple inter-fiducial pulse periods
Systems and methods are provided for determining the pulse rate of a patient from multiple fiducial points using Gaussian kernel smoothing. Based on acquired pleth signals, each recorded fiducial pulse period is converted to a Gaussian kernel function. The Gaussian kernel functions for all recorded fiducial points are summed to generate a Gaussian kernel smoothed curve. The pulse rate of a patient may be determined from the Gaussian kernel smoothed curve. All acquired fiducial pulse periods contribute to generate the Gaussian kernel smoothing curve. The number of fiducial points utilized may change to improve pulse rate determination or provide additional functionality to the system.
US08870782B2 Pulse wave analyzer and blood pressure estimator using the same
In a pulse wave analyzer, an ECG signal and a pulse wave signal are detected from an object to be analyzed. A plurality of feature points are extracting from the acquired ECG signal, the feature points appearing in a waveform of the ECG signal. The acquired pulse wave signal is segmented into a plurality of pulse wave signal pieces based on times at which the feature points appear. Each of the pulse wave signal pieces is segmented every heart beat. A reference pulse wave is calculated based on the plurality of pulse wave signal pieces, by multiplying the pulse wave signal pieces by coefficients and averaging the pulse wave signal pieces multiplied by the coefficients. The reference pulse wave is used to estimate the blood pressure of the object.
US08870779B2 Display of two-dimensional ultrasound fan
A medical imaging system for imaging a patient's body includes a catheter having a position sensor and an ultrasonic imaging sensor wherein the position sensor transmits electrical signals indicating positional information of the catheter in the patient's body and the ultrasonic imaging sensor transmits ultrasonic energy at a target in the patient's body, receives ultrasonic echoes reflected from the target and transmits signals relating to the reflected ultrasonic echoes. A positioning processor is connected to the catheter for determining its positional information based on the electrical signals transmitted by the position sensor. The system includes a display and an image processor connected to the catheter, the positioning processor and the display. The image processor generates an ultrasonic image of the target and depicts the generated ultrasound image on the display in the same orientation as the catheter in the patient's body based on positional information from the position sensor.
US08870770B2 Low-cost device for C-scan acoustic wave imaging
The prostate gland or other region of interest is stimulated with either a light source or an ultrasound source, resulting in photoacoustic or ultrasound acoustic waves which are focused by an acoustic lens and captured by a specific 1- or 2D sensor array and subsequently displayed as a C-scan on a computer screen. The amplitude of the waves generated by the stimulation is proportional to the optical absorption of the tissue element at that spatial location. Variability in tissue absorption results in C-scan image contrast.
US08870763B2 Method and/or system for multicompartment analyte monitoring
Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.
US08870761B2 Illuminated suction apparatus
An illuminated suction apparatus including a hand-held surgical device combining a high-performance non-fiber optic optical waveguide with suction. This device is useful in a wide array of surgical procedures including open and minimally invasive orthopedics.
US08870759B2 Suspension system for minimally invasive surgery
A suspension system for supporting surgical devices inside a patient's body cavity comprising an external frame, a plurality of elongated members extending from the external frame and through the patient's skin into the body cavity, and an internal platform located inside the body cavity. The internal platform includes a plurality of links reconfigurable from a first elongated position wherein the links are substantially aligned along a longitudinal axis for insertion to a second position wherein the links are angled with respect to one another to form a non-linear configuration.
US08870757B2 Method, device and endoscopy capsule to detect information about the three-dimensional structure of the inner surface of a body cavity
In a method and a device to detect information about the three-dimensional structure of the inner surface of a body cavity of a patient with an endoscopy capsule introduced into said body cavity, a first partial region of the inner surface of the body cavity is illuminated with at least one light source arranged in the endoscopy capsule and an image of a second partial region that is illuminated by the first partial region and differs from the first partial region. The three-dimensional structure of the second partial region is known, and the second partial region is acquired with at least one camera arranged in the endoscopy capsule. Information about the three-dimensional structure of the first partial region is derived using the intensity values in this image.
US08870748B2 Rigid arthroscope system
A reinforced arthroscope comprising external ribs to provide for a number of separate fluid channels, such as inflow, outflow and interstitial tissue drainage, when the arthroscope is slipped into a disposable external sheath. The arthroscope is constructed to be sufficiently rigid so as to penetrate and move within a joint without damaging the rod optics inside. The externality of the arthroscope channels allow for cleaning and sterilizing the scope between uses.
US08870747B2 Scraping fluid removal in a surgical access device
The present invention generally provides methods and devices for removing fluid from a surgical instrument. Surgical access devices and seal systems are generally provided having one or more valves or seal assemblies to create a closed system between the outside environment and the environment in which the surgical access device is being inserted. In one embodiment, a seal assembly is provided and can include a seal having an opening configured to receive a surgical instrument therethrough and a fluid remover in the form of an absorbent element, a scraper element, a wicking element, or any combination thereof can be associated with the seal and configured to remove fluid from the opening and/or a surgical instrument.
US08870745B2 Pelvic floor repair implants
The invention generally relates to surgically implantable supportive slings. More specifically, in various embodiments, the invention is directed to sling assemblies for pelvic floor repair that utilize one or more materials, attached without a mechanical fixation device, and related methods of use and fabrication.
US08870741B2 Assembly and method for attaching particularly a vagina to a spine
Assembly for attaching a patient's vaginal apex or uterus or rectum to her/his spine, includes a first tube having a length adapted to the distance from the outer wall of the patient's abdomen to the sacrum. The first tube has a distal end for engagement with the sacrum, an opposite proximal end, and a first passage from the distal to the proximal end thereof, a second tube having a length that at least equals the length of the first tube. The second tube has a distal end and an opposite proximal end, at least one attachment element with a distal end for attachment to the sacrum and a proximal end for attachment of an end of connection element for connection to the patient's vaginal apex or uterus or rectum, such as one or more threads.
US08870735B2 Waste disposal
The waste disposal system disclosed herein includes a chamber operated at high ampere and low voltage, the chamber configured to inject smoke on a stream of free radicals. In one implementation, the stream of free radicals is generated from a plasma igniter and the smoke is generated from waste products, such as hospital waste products.
US08870733B2 Centrifuge
Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.
US08870729B2 Straw applicator
An apparatus for applying drinking straws on prefabricated packaging containers includes a drive device for continuous belts of drinking straws wrapped in protective sleeves or envelopes, a conveyor for moving packaging containers past the drinking straw applicator, a separator for separating drinking straws from the belt, as well as an applicator for applying the drinking straw on a side wall of the packaging container. The drinking straw applicator include at least one eccentric which is eccentrically disposed on a shaft mounted adjacent the drive device. During rotation of the shaft, the eccentric is moved from an inner position to an outer position, a drinking straw is picked up at the inner position and is applied on a packaging container at the outer position.
US08870721B2 Gymnastic machine
Functional group (1) for a gymnastic machine (100) provided with a frame (110) supporting a load group (120) usable for executing a gymnastic exercise; the machine (1) comprising an actuating group (130) provided with at least one user interface (132) carried movable by the frame (110) to exchange power with the load group (120); a modular transmission member (10) being arranged between each user interface (132) and the load group (120) to exchange power between these latter so as to facilitate the assembling and disassembling of the frame (110).
US08870720B1 Exercise machine with lifting arm
An exercise machine has a main frame and a user support movably mounted relative to the main frame for movement between a start position and an end position during an exercise. At least one user engagement device is movably mounted relative to the main frame for engagement and actuation by a user during an exercise, and a connecting linkage translates movement of the user engagement device to movement of the user support. A lifting arm is movably mounted relative to the main frame and associated with at least one of the user support, user engagement device, and connecting linkage so as to move during an exercise. A load associated with the lifting arm provides exercise resistance.
US08870719B2 All in one fitness ball
A new weighted ball exercise device is disclosed. The ball has handles connected to covers located on opposite sides of the ball. The handles rotate 360 degrees clockwise or counterclockwise. The handles alleviate stress on the user's wrists and provide a firm grip. The ball has an internal weight storage compartment or weight drawer that may be opened to permit adding or removing weights of various sizes and weights. The compartment can be axially located between the covers, and be locked and unlocked by action of spring-loaded button mechanism. In another embodiment, the ball has opposing rotatable covers with handles and grips. Weights are removably insertable into one or more recessed compartments located about the ball's outer surface, and may be radially spaced apart. A kettle bell handle attachment can be inserted into the outer surface to permit conversion of the ball to a kettle ball device.
US08870718B2 Flexible shroud for exercise equipment
A flexible shroud is used to cover weights and hide pulleys and cables on exercise machines. The flexible shroud can be a coarse mesh or screen for see through areas, cloth such as canvas or other fabrics, or other flexible sound absorbing materials. The material may be supported around or between a framework of ribs, poles, or metal screen and takes the shape of the framework. The material may also be supported only at the top and bottom of a weight stack or structure by a rigid template from which the material takes shape. The top or bottom support may be adjusted to stretch the fabric taut so it takes shape better and tightens to provide a better safety shield. The material may be attached to the supports or framework by snaps, hook and loop material, or other removable fasteners.
US08870717B2 Exercise device
An exercise device is disclosed having a main body including a material chamber formed therein. A flowable material is disposed within the material chamber and a level indicator is coupled to the main body. The exercise device is grasped by user. The flowable material and the level indicator provide sensory feedback to the user in respect of maintaining the exercise device in a substantially level position while in use.
US08870715B2 Knee exerciser
An apparatus for flexing the knee comprising a U-shaped bar having two straight arms each having a distal end and a handle portion generally perpendicular to the straight arms and a perpendicular cross-member adjustably attached to the straight arms; and a method for flexing the knee comprising the steps of providing a patient with device having a handle section and two parallel straight sections with a perpendicular cross-member attached to the straight sections, having the patient to place his or her foot onto the cross-member, and having the patient to pull the device toward the knee.
US08870712B2 Method for shift control of an automated group gear
A method of controlling a shift of an automated group gearbox having a multi-step main transmission and a trailing two-step range group. An input shaft of the main transmission is driven by a drive device. The main transmission and a range group have synchronization devices with shift clutches. Each synchronization device, for the main transmission, has two shift positions for respective gear ratio steps and a neutral position and the range group synchronization device has only two shift positions to shift between two gear ratios steps. To accelerate range shifts, when synchronizing the range group, the main transmission input shaft is synchronized by controlling external synchronization aids to a target rotational speed at which either after the synchronization and shifting of the gear ratio step of the range group or independently from the current synchronization condition of the range group, the target gear ratio is engaged in the main transmission.
US08870711B2 Continuously variable transmission
Inventive embodiments are directed to components, subassemblies, systems, and/or methods for continuously variable accessory drives (CVAD). In one embodiment, a skew-based control system is adapted to facilitate a change in the ratio of a CVAD. In another embodiment, a skew-based control system includes a skew actuator coupled to a carrier member. In some embodiments, the skew actuator is configured to rotate a carrier member of a CVT. Various inventive traction planet assemblies can be used to facilitate shifting the ratio of a CVT. In some embodiments, the traction planet assemblies include legs configured to cooperate with the carrier members. In some embodiments, a traction planet assembly is operably coupled to the carrier members. Embodiments of a shift cam and traction sun are adapted to cooperate with other components of the CVT to support operation and/or functionality of the CVT. Among other things, shift control interfaces for a CVT are disclosed.
US08870703B2 Transmission with band clutch
A transmission is provided having a housing, a plurality of planetary gear sets, a structural member, a sprocket member, an annular drum, a band, and an actuator. The sprocket member is rotationally supported by the structural member. The annular drum is adjacent the structural member and is continuously rotationally coupled with a member of the one of the plurality of planetary gear sets. The band circumscribes the annular drum and includes at least a first position and a second position. In the first position the band is substantially separated from the drum and in the second position the band contacts the drum. The actuator selectively positions the band between at least the first position and the second position to transfer torque between the structural member and the annular drum.
US08870701B2 Double differential device for a vehicle
A double differential device for a vehicle which is of compact construction. The device has a longitudinal differential section with a longitudinal differential input, a longitudinal differential output, an axle output. It also has a transverse differential section with a transverse differential input and two driven outputs. The longitudinal differential output is connected with the transverse differential input, the longitudinal differential section and the transverse differential section are each a planetary spur wheel gear and are arranged coaxially with a common main axis of rotation. The longitudinal differential section has a longitudinal differential planet carrier, which carries a longitudinal differential planet set, and the transverse differential section has a transverse differential planet carrier, which carries a first and a second transverse differential planet set. The longitudinal differential planet carrier and the transverse differential planet carrier are arranged rotatable relative to one another, and the two driven outputs are driven suns.
US08870699B2 Lubrication oil system for a reduction gearbox
A reduction gear box is part of a gas turbine engine and includes a casing and reduction epicyclic gear stages within the casing. The reduction gear stages comprising at least an epicyclic array of gears meshing together with at least one planetary gear mounted for rotation on a gear carrier and a bearing associated therewith. A lubricating oil delivery system is provided within the casing, surrounding a portion of the gear carrier. The oil delivery system includes a conduit; a closed oil reservoir; a first metered opening communicating the conduit with the reservoir and a plurality of metered outlet openings communicating the reservoir with the gear carrier and the bearing such that the reservoir is filled with oil in normal flight operating conditions and the oil trapped in the reservoir is released to the carrier and bearing when a temporary drop in the oil system pressure occurs.
US08870693B2 Bicycle derailleur with rotation resistance and tactile feedback
A bicycle derailleur comprises a base member, a movable member movably coupled to the base member, and a chain guide coupled to the movable member for rotation around a rotational axis. A resistance-applying element applies resistance to rotational movement of the chain guide, and a resistance control element moves between at least different first and second positions. The resistance control element is operatively coupled to the resistance-applying element so that the resistance-applying element applies different first and second resistances to rotational movement of the chain guide when the resistance control element is disposed in the respective first and second positions. A jolt element is disposed within the movable member and is operatively associated with the resistance control element to provide a tactile jolt to a user as the user moves the resistance control element from the first position to the second position.
US08870692B2 Bicycle derailleur with rotation resistance
A bicycle derailleur comprises a base member, a movable member movably coupled to the base member, and a chain guide coupled to the movable member for rotation around a rotational axis. A resistance applying element applies resistance to rotational movement of the chain guide. A resistance control element moves between at least different first and second positions, wherein the resistance control element is disposed so that the resistance control element can be directly manipulated by a user without using a tool. The resistance control element is operatively coupled to the resistance applying element so that the resistance applying element applies different first and second resistances to rotational movement of the chain guide when the resistance control element is disposed in the respective first and second positions.