| Document | Document Title |
|---|---|
| US08610065B2 |
Readout integrated circuit for infrared signal and method of reading out infrared signal
There is provided a readout integrated circuit for an infrared signal that is able to operate at low power and reduce a pixel pitch without the use of a skimming capacitor. |
| US08610061B2 |
Scanning electron microscope
A seal member to be contacted with an observation object is provided at an open end of a lens barrel so that the observation object can be attracted to the lens barrel via the seal member and fixed in direct and close contact with the lens barrel when a vacuum is created in the lens barrel by a vacuum pump. In other words, instead of providing a sample chamber, the observation object is fixed in close contact with the lens barrel to prevent relative movement therebetween by a suction force even without a sample chamber. In this configuration, the interior of the lens barrel can be maintained in a vacuum state despite the absence of a sample chamber and no adverse effect occurs during observation because the lens barrel and the observation object are not moved relative to each other by vibration. |
| US08610060B2 |
Charged particle beam device
An object of the present invention is related to detecting of a detection signal at an optimum position in such a case that a sample plane is inclined with respect to a charged particle beam.The present invention is related to a charged particle beam apparatus for irradiating a charged particle beam to a sample, in which a detector is moved to a plurality of desirable positions around the sample so as to optimize positions of the detector. In accordance with the present invention, since it is possible to obtain an optimum detection signal in response to an attitude and a shape of the sample, a highly accurate sample observation, for instance, an SEM observation, an STEM observation, and an FIB observation can be carried out. Moreover, in an FIB-SEM apparatus, it is possible to highly accurately detect an end point of an FIB process. |
| US08610056B2 |
Multipole ion guide ion trap mass spectrometry with MS/MSn analysis
An apparatus includes an atmospheric pressure ion source; a first vacuum stage and a second vacuum stage separated from the first vacuum stage by a vacuum partition; a first ion guide positioned within a first vacuum stage and arranged to receive ions from the atmospheric pressure ion source; a second ion guide positioned within a second vacuum stage downstream of the first vacuum stage from the atmospheric pressure ion source, the second ion guide being a multipole ion guide arranged to receive ions from the first ion guide; and a time-of-flight mass analyzer that includes an orthogonal pulsing region arranged to receive ions from the second ion guide. |
| US08610054B2 |
Ion analysis apparatus and method of use
The present invention is concerned with an ion analysis apparatus for conducting differential ion mobility analysis and mass analysis. In embodiments, the apparatus comprises a differential ion mobility device in a vacuum enclosure of a mass spectrometer, located prior to the mass analyzer, wherein the pumping system of the apparatus is configure to provide an operating pressure of 0.005 kPa to 40 kPa for the differential ion mobility device, and wherein the apparatus includes a digital asymmetric waveform generator that provides a waveform of frequency of 50 kHz to 25 MHz. Examples demonstrate excellent resolving power and ion transmission. The ion mobility device can be a multipole, for example a 12-pole and radial ion focusing can be achieved by applying a quadrupole field to the device in addition to a dipole field. |
| US08610052B2 |
Testing an infrared proximity sensor
A system for testing an IR proximity sensor has an infrared reflector that receives radiation transmitted from the proximity sensor under test. An electronically modulated IR-transmissive device is positioned between the sensor and the reflector. A tester is coupled to control the IR-transmissive device for testing the sensor. Other embodiments are also described and claimed. |
| US08610051B2 |
Incremental optical encoder
The invention relates to optical encoders providing binary logic signals representing increments of relative position of two elements of the encoder, the two elements being mobile with respect to one another. The encoder includes at least one pair formed of a luminous emitter and of a luminous detector which are secured to the fixed element, the emitter producing a luminous radiation that the detector can detect, and at least one mark secured to the movable element, during the motion of the movable element with respect to the fixed element, the mark being able to place itself in the path of the luminous radiation so as to be detected by the detector. The encoder further includes a plane printed circuit, secured to the fixed element and on which the pair of emitter and detector is arranged. |
| US08610050B2 |
Optical displacement detection apparatus
An optical displacement detection apparatus includes a scale and a sensor head. The scale has a first and second pattern. The head includes a first photodetector that detects a beam through the first pattern and generates a first signal, and a second photodetector that detects the beam through the second pattern and generates a second signal. The first and second signals include a first component, and a second component that corresponds to an absolute displacement of the scale. The first pattern, the second pattern, the first photodetector, the second photodetector, and a beam source are disposed such that the detection of the first photodetector and the detection of the second photodetector are performed correlatively. |
| US08610049B2 |
Apparatus, system, and method for emission filter having a solution with polar protic solvent
An apparatus, system, and method for emission filter. A filter apparatus is presented. In one embodiment, the filter apparatus may be adapted for fluorescence spectroscopy. In a particular embodiment, the filter apparatus comprises a solution. The solution may include a polar protic solvent and an absorbing specimen. Additionally, the filter apparatus may include an adhesive to conform the solution into a solid filter. |
| US08610048B2 |
Photosensitive integrated circuit equipped with a reflective layer and corresponding method of production
A method for producing a photosensitive integrated circuit including producing circuit control transistors, producing, above the control transistors, and between at least one upper electrode and at least one lower electrode, at least one photodiode, by amorphous silicon layers into which photons from incident electromagnetic radiation are absorbed, producing at least one passivation layer, between the lower electrode and the control transistors, and producing, between the control transistors and the external surface of the integrated circuit, a reflective layer capable of reflecting photons not absorbed by the amorphous silicon layers. |
| US08610045B2 |
Analog signal buffer and image reading device using the analog signal buffer
The analog signal buffer is connected with a photoelectric converter to convert an optical image to an analog signal and an analog signal processing circuit to convert the analog signal to a digital signal, and transmits the analog signal to the analog signal processing circuit. The analog signal buffer includes a first buffer having a NPN transistor; and a second buffer having a PNP transistor. The first buffer includes a circuit to block a reverse current caused in the analog signal buffer by dropping of a voltage output from the photoelectric converter. |
| US08610042B2 |
Pyrotechnic fin deployment and retention mechanism
A fin retention and deployment mechanism includes a detent in each of a plurality of fins, a mechanism that engages the detent, and at least one spring clip that maintains each of the fins in a non-deployed position. The mechanism also includes a gas generator, a manifold, coupled to the gas generator and having a plurality of cylinders in fluid communication with gas from the gas generator, and a plurality of pistons disposed in the cylinders. A bottom of each of the pistons is coupled to each of the fins to provide deployment thereof when a corresponding top of each of the pistons is acted upon by gas from the gas generator. In response to the gas generator expelling gas, the pistons may move the fins to a deployed position. |
| US08610041B1 |
Missile tracking by GPS reflections
A system for engaging hostile air or space threats with a defensive missile, where the defensive missile comprises an antenna for receiving global positioning system (GPS) signals. A global positioning system receiver is coupled to said antenna, for receiving global positioning system signals directly from global positioning system satellites and global positioning system signals reflected from the threat. A processing arrangement processes the direct and reflected global positioning system signals for determining the position and velocity of the threat. Vectoring controls are coupled to the processing arrangement, and are responsive to the location of the threat for directing the defensive missile toward the threat. In a particular embodiment, the antenna of the defensive missile is directionally controllable, and the defensive missile includes an antenna direction controller responsive to the processor for directing at least a beam of the antenna toward the threat. |
| US08610039B2 |
Vent assembly for microwave cooking package
A vent assembly includes a bag construction configured to contain a food product such as a popcorn charge. The bag construction is formed of at least one sheet of polyester film material and configured to expand from a collapsed configuration to an expanded configuration when the food product is heated in a microwave oven. The vent assembly includes a first portion of the bag construction and a second portion of the bag construction that is configured to be folded against the first portion. The second portion includes a venting structure formed in the sheet of polyester material. An adhesive is applied to at least one of the first portion or the second portion. The adhesive is configured to adhere the first portion to the second portion so that the vent is at least partially sealed while the bag construction is in the collapsed configuration and to release the first portion from the second portion as the bag construction expands to the expanded configuration to allow the vent to at least partially open. |
| US08610031B2 |
Method of arc welding root pass
A method for root pass welding steel plate and pipe is provided that uses pulse arc welding having a current pulse waveform exhibiting a low constant background current and fixed frequency. The welding process may be performed without a backer or backing material. |
| US08610029B2 |
Systems and methods for using a portion of a housing in a button assembly
Systems and methods for cutting a cover from a portion of a housing of an electronic device, and positioning the cover within the housing are provided. An electronic device can include an interface having an actuator over which a cover is placed. The cover can by cutting away a portion of a housing of the electronic device. To improve the aesthetic appeal of the device, the orientation of the cover can be maintained while and after it is cut away from the housing by a fixture used for the cutting process. An adhesive sheet can be placed over the housing and the cover to ensure that the cover remains stationary relative to the housing once it is separated from the housing. |
| US08610026B2 |
Laser welding method
The method of lap-welding of metal plates using a laser beam, wherein at least one of the metal plates is surface-treated, includes putting a metal plate on the other metal plate and forming a gap between the metal plates so that gas generated at the treated surface at the time weld can be dissipated therethrough. A surface-treated first work and a surface-treated second work are placed one on the other and clamped by a clamp with an opening of the clamp centered at the location on the first work to be welded. Then a laser beam is directed to the location to form a weld. The beam is then directed near the inner periphery of the opening to form a heated portion so that the heated portion deflects to form a gap through which the gas generated at the treated surface dissipates thereby reducing gas pressure. |
| US08610024B1 |
Apparatus and method for producing a lunar agglutinate simulant
An exemplary embodiment providing one or more improvements includes a device and method for producing a lunar agglutinate simulant in which batch material is supported and moved through a plasma arc at a rate which partially reacts the batch material. |
| US08610020B2 |
Method for sorting postal objects
A method including treating packs of overlapping postal objects for generating singulated postal objects, directing each postal object towards a respective outlet selected from among a number n of selectable outlets. The method includes performing a first sorting step, accumulating, within an i-th selected outlet, postal objects belonging to K subgroups having homogeneous delivery points, and carrying out a step of re-processing the previously sorted postal objects, whereby the postal objects taken from the outlets are treated for forming ordered sets of postal objects, each set comprising the postal objects belonging to a respective homogeneous subgroup and being formed by postal objects ordered according to successive delivery points; and performing a second step of sorting ordered sets, on the basis of which the postal objects that have corresponding positions within each subgroup are sent to the respective outlets. The objects are accumulated according to successive delivery points in the outlets. |
| US08610016B2 |
Plug wire type zipper switch lampholder
A plug wire type zipper switch lampholder having a zipper for driving a lever and a rotating conductive rod to rotate, so that both ends of a rotating conductive rod jumps between slopes with a first conductive plate and a second conductive plate and slopes without the first conductive plate and the second conductive plate to achieve the operation of switching on and off a light emitting element. In the meantime, a power line can be electrically conducted to an external power supply by a simple plugging process. |
| US08610013B2 |
Rotary control with haptic effects and method of manufacturing thereof
A rotary switch assembly includes a knob, a wheel joined to the knob, a first frame that moves toward the wheel, a second frame joined to the first frame, and a shape memory alloy member made from a shape memory alloy and joined to the second frame. The shape memory alloy member changes shape, and the second frame transforms the changing shape of the shape memory alloy member into movement of the first frame. |
| US08610012B2 |
Electrical switch operable through both manual and motor driven operations
An arrangement includes an electrical switch which has a handle that can assume at least three different positions, namely an ON position, an OFF position and a TRIPPED position, and a motor drive that is mounted on said switch and is provided for the purpose of activating the handle. According to an embodiment of the invention, provision is made for the motor drive to feature a motor-drive-specific indicator entity which indicates whether the switch can be closed by way of the motor drive, wherein the motor-drive-specific indicator entity is connected to at least one switch-specific actuator and to at least one motor-drive-specific actuator, and indicates a closure-unreadiness of the arrangement if at least one of the actuators signals a closure-unreadiness. |
| US08610010B2 |
Control element for a motor vehicle
The invention relates to a rotary control element comprising a control element body and a rotary button (1) mounted so as to be rotatable about at least one axis of rotation (9), wherein the control element body and the rotary button (1) cooperate such that a first associated switching function is provided by rotating the rotary button (1). The rotary control element according to the invention is characterized by the rotary button (1) being mounted so as to be displaceable relative to the control element body in at least one direction which is substantially perpendicular relative to the axis of rotation (9), with at least one additional switching function being provided. |
| US08610007B2 |
Portable electronic device and method for measuring object weight using the portable electronic device
An object is weighed using a portable electronic device. Placement of an object on a touch panel of the portable electronic device provides measurement of the weight of the object. In the measurement, the portable electronic device sends information to the touch panel to request a user to input a unit price of the object. The portable electronic device then detects a weight of the object placed on the touch panel. The portable electronic device calculates a total price of the object by multiplication of the input unit price and the detected weight of the object. The total price of the object can be then output. |
| US08610002B2 |
Cover for electronic equipment
Cover for electronic equipment including at least two movable metal panel elements. The panel elements are joined together along their respective edges, so they are joined together and in relation to each other immobile state form the cover. The invention is wherein the cover includes a respective connector for mechanical joining and good electric contacting along each one of the edges along which the panel elements are arranged to be joined together, in that each connector includes a respective resilient metal contacting device, which contacting device is arranged between the respectively joined together panel elements and in direct contact with both panel elements when the panel elements are in the joined together state, and thereby is compressed against the spring force of the contacting device, so that the spring force acts against the surfaces of both the respective joined together panel elements and connects them to each other electrically. |
| US08609992B2 |
Circuit board, manufacturing method of circuit board, suspension substrate, suspension, device-mounted suspension, and hard disk drive
The problem of the present invention is to provide a circuit board comprising a shape retention unit capable of thinning while maintaining mechanical strength. The present invention solves the above-mentioned problem by providing a circuit board comprising a metal supporting substrate, a first insulating layer formed on the above-mentioned metal supporting substrate, and a wiring layer formed on the above-mentioned first insulating layer, wherein an open area is formed in the above-mentioned metal supporting substrate, and the circuit board comprises a shape retention unit having a second insulating layer contacting with the above-mentioned metal supporting substrate and a reinforcing layer formed on the above-mentioned second insulating layer, and bridging the above-mentioned metal supporting substrate divided by the above-mentioned open area. |
| US08609988B2 |
Electric wire with terminal and method of manufacturing the same
An electric wire with a terminal includes a conductor, and the terminal is connected to an end portion of the conductor. The terminal includes a first connecting portion connected to an electrical equipment and a second connecting portion connected to the conductor. The second connecting portion includes a first connection surface and a second connection surface opposite to the first connection surface. The conductor includes a first conductor and a second conductor that are connected to the first connection surface and the second connection surface, respectively, by ultrasonic bonding. The connecting portion of the first connection surface overlaps the connecting portion of the second connection surface in a perpendicular direction to an axial direction of the conductor. |
| US08609984B2 |
High efficiency photovoltaic cell for solar energy harvesting
A photovoltaic cell comprising having improved absorption of electromagnetic radiation is disclosed. The photovoltaic cell can include a rear contact, a first cell having a first band-gap energy, and a rear contact in electrical communication with an electromechanical device. The first cell can include InxGaySbz, where x+y+z=1 and z ranges from 0.00001 to 0.025. the photovoltaic cell can also include a second cell having a second band-gap energy, and a first tunnel disposed between the first and second cells. The photovoltaic cell can include at least a third cell and a second tunnel disposed between the second and third cells. The uppermost cell can include GaP or InP. |
| US08609981B2 |
P-type transparent conductive oxide for solar cell comprising molybdenum trioxide doped with indium
A p-type transparent conductive oxide and a solar cell containing the p-type transparent conducting oxide, wherein the p-type transparent conductive oxide includes a molybdenum trioxide doped with an element having less than six valence electrons, the element is selected from the group consisting of alkali metals, alkaline earth metals, group III elements, group IV, group V, transition elements and their combinations. Doping an element having less than six valence electron results in hole number increase, and thus increasing the hole drift velocity, and making Fermi level closer to the range of p-type materials. Hence, a p-type transparent conductive material is generated. This p-type transparent conducting oxide not only has high electron hole drift velocity, low resistivity, but also reaches a transmittance of 88% in the visible wavelength range, and therefore it is very suitable to be used in solar cells. |
| US08609980B2 |
Cross-linkable ionomeric encapsulants for photovoltaic cells
Provided herein is a blend composition useful as a cross-linkable encapsulant layer and consisting essentially of two ethylene copolymers and optionally one or more additives. The first ethylene copolymer comprises copolymerized units of ethylene, optionally a first olefin having the formula CH2═C(R1)CO2R2, and a second olefin having the formula CH2═C(R3)COOH. At least a portion of the carboxylic acid groups have been neutralized to form carboxylate salts. The second ethylene copolymer consists essentially of copolymerized units of ethylene, optionally a first olefin having the formula CH2═C(R1)CO2R2, and a third olefin having the formula CH2═C(R4)D. R1, R3 and R4 represent hydrogen or an alkyl group; R2 represents an alkyl group; and D represents a moiety containing an epoxy group. Further provided are solar cell modules comprising the encapsulant layer. The encapsulant layer comprises the blend composition or the product of cross-linking the blend composition, in which some carboxylate groups of the second olefin have reacted with some epoxy groups of the third olefin. |
| US08609979B2 |
Electromagnetic radiation concentrating system
As the concentration of electromagnetic radiation, especially solar radiation, can be utilized for constructive purposes it becomes desirable to concentrate the radiation in an economical manner. An essentially fixed concentrating reflector whose shape is generated by gravity's effect on flexible members provides an efficient means to collect and concentrate radiation. Historically in optical science aberrations are to be avoided or eliminated, however this device utilizes the aberration of astigmatism. By taking advantage of the astigmatic foci created by obliquely incident radiation falling upon a substantially sphere-like primary, a comparatively large fixed concentrator can be constructed inexpensively. The resulting tangential and sagittal astigmatic foci are linear. The length of the astigmatic foci can be a substantial portion of the diameter of the concentrator, especially at times of lower solar elevation. A toric shaped deformation of the reflective surface reduces the size of the chosen astigmatic focus to yield higher concentration. In the ideal the astigmatic focus is reduced to a point. A receiver located at the reduced astigmatic focus utilizes the concentrated radiation. |
| US08609976B2 |
Solar cell module
A solar cell module includes a plurality of solar cells. M first bus bar electrodes are disposed on a first surface of each of the solar cells. N second bus bar electrodes are disposed on a second surface of each of the solar cells. M is a natural number that is equal to or larger than 1, and N is a natural number that is larger than M. |
| US08609972B2 |
Performance apparatus and electronic musical instrument operable in plural operation modes determined based on movement operation of performance apparatus
A performance apparatus 11 is provided with a first acceleration sensor 22 at its head portion and a second acceleration sensor 23 at its base portion. CPU 21 determines operation of the performance apparatus 11 during a period from the first timing to the second timing, based on a first acceleration-sensor value and a second acceleration-sensor value, and determines operation mode corresponding to the operation of the performance apparatus. Referring to a tone-color table stored in RAM 26, CPU 21 determines a tone color of musical tones to be generated, based on the determined operation mode. |
| US08609970B2 |
Suspended drum microphone system
Improvements in a microphone system for a musical instrument and more particularly for a percussion instrument such as a drum, marimba or similar musical instrument. The microphone system includes a vibration isolation system. A vertical or horizontal tracking system bridges across supports of a drum or marimba in a vertical or horizontal tracking system. One or more microphones are supported on the first bridging structure. The microphone(s) are positionally secured on the horizontal tracking system. Both the microphones and the horizontal tracking system provide vibration isolation to all of the microphones. A cable managements system is also disclosed to reduce mechanical vibration and eliminate transmission of undesirable sounds. |
| US08609968B1 |
Salsa metronome
A salsa metronome provides a practice rhythm in the style of salsa music to facilitate practice for a musician, singer or dancer. The metronome includes a housing and a control unit positioned in the housing. The control unit produces multiple polyrhythmic sound patterns. A rhythm selection control is coupled to the housing. The rhythm selection control is operationally coupled to the control unit for selecting a desired polyrhythmic sound pattern. A speaker is positioned in the housing and is operationally coupled to the control unit for audibly producing the selected polyrhythmic sound pattern. |
| US08609967B2 |
Top-tuning system for hand percussion instrument
Disclosed is a tuning system for tuning a hand percussion instrument having a head and a shell. The tuning system comprises a rim, the rim secured to the head of the instrument, the rim comprising at least one receptacle, the receptacle positioned at outer periphery of the rim such that the receptacle body is below the plane of the rim, a side plate assembly, the side plate assembly secured to the shell of the instrument, a tuning rod, the tuning rod having a first end secured to the receptacle for varying the tension on the head, and the tuning rod having a second end secured to the side plate assembly. |
| US08609965B2 |
Hand actuated tremolo system for guitars
A tremolo device with a movable bridge, an adjustment device, and a support frame is implemented on an acoustic guitar, with features that can also be employed on an electric guitar or other stringed instruments. The movable bridge holds strings of the musical instrument in tension. The adjustment device, such as a tremolo bar, moves the bridge to change the tension of the strings. The support frame engages the bridge at a first area and engages the musical instrument at a larger second area. When the tremolo device is used, the support frame receives a force over the first area and transmits a corresponding force to the musical instrument over the larger second area, reducing the pressure that would be experienced by the musical instrument. The support frame also transmits string vibration received through the bridge to the instrument body to produce proper acoustic tones. |
| US08609962B1 |
Maize inbred PH1JP9
A novel maize variety designated PH1JP9 and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1JP9 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1JP9 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1JP9 or a locus conversion of PH1JP9 with another maize variety. |
| US08609958B1 |
Maize variety hybrid X13B634
A novel maize variety designated X13B634 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X13B634 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X13B634 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X13B634, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X13B634. This invention further relates to methods for producing maize varieties derived from maize variety X13B634. |
| US08609956B1 |
Maize variety hybrid X08B817
A novel maize variety designated X08B817 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X08B817 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X08B817 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X08B817, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X08B817. This invention further relates to methods for producing maize varieties derived from maize variety X08B817. |
| US08609954B2 |
Bean variety RX 08075309
The invention provides seed and plants of the bean line designated RX 08075309. The invention thus relates to the plants, seeds and tissue cultures of bean line RX 08075309, and to methods for producing a bean plant produced by crossing a plant of bean line RX 08075309 with itself or with another bean plant, such as a plant of another line. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of a plant of bean line RX 08075309, including the pods and gametes of such plants. |
| US08609952B1 |
Soybean cultivar 15120100
A soybean cultivar designated 15120100 is disclosed. The invention relates to the seeds of soybean cultivar 15120100, to the plants of soybean cultivar 15120100, to the plant parts of soybean cultivar 15120100, and to methods for producing progeny of soybean cultivar 15120100. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 15120100. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 15120100, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 15120100 with another soybean cultivar. |
| US08609950B2 |
Soybean variety A1026170
The invention relates to the soybean variety designated A1026170. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1026170. Also provided by the invention are tissue cultures of the soybean variety A1026170 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1026170 with itself or another soybean variety and plants produced by such methods. |
| US08609948B2 |
Soybean variety A1026010
The invention relates to the soybean variety designated A1026010. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1026010. Also provided by the invention are tissue cultures of the soybean variety A1026010 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1026010 with itself or another soybean variety and plants produced by such methods. |
| US08609947B2 |
Soybean variety A1024710
The invention relates to the soybean variety designated A1024710. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1024710. Also provided by the invention are tissue cultures of the soybean variety A1024710 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1024710 with itself or another soybean variety and plants produced by such methods. |
| US08609943B1 |
Soybean variety XB34D12
A novel soybean variety, designated XB34D12 is provided. Also provided are the seeds of soybean variety XB34D12, cells from soybean variety XB34D12, plants of soybean XB34D12, and plant parts of soybean variety XB34D12. Methods provided include producing a soybean plant by crossing soybean variety XB34D12 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB34D12, methods for producing other soybean varieties or plant parts derived from soybean variety XB34D12, and methods of characterizing soybean variety XB34D12. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB34D12 are further provided. |
| US08609942B2 |
Soybean cultivar S090089
A soybean cultivar designated S090089 is disclosed. The invention relates to the seeds of soybean cultivar S090089, to the plants of soybean cultivar S090089, to the plant parts of soybean cultivar S090089, and to methods for producing progeny of soybean cultivar S090089. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S090089. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S090089, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S090089 with another soybean cultivar. |
| US08609941B1 |
Soybean cultivar CL0911407
The present invention is in the field of soybean variety CL0911407 breeding and development. The present invention particularly relates to the soybean variety CL0911407 and its progeny, and methods of making CL0911407. |
| US08609939B1 |
Soybean cultivar CL0911670
The present invention is in the field of soybean variety CL0911670 breeding and development. The present invention particularly relates to the soybean variety CL0911670 and its progeny, and methods of making CL0911670. |
| US08609938B2 |
Soybean cultivar 7904162
A soybean cultivar designated 7904162 is disclosed. The invention relates to the seeds of soybean cultivar 7904162, to the plants of soybean cultivar 7904162, to the plant parts of soybean cultivar 7904162, and to methods for producing progeny of soybean cultivar 7904162. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 7904162. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 7904162, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 7904162 with another soybean cultivar. |
| US08609937B2 |
Bacillus thuringiensis gene with coleopteran activity
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests, including Coleoptera. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests. |
| US08609935B2 |
Soybean event DP-305423-1 and compositions and methods for the identification and/or detection thereof
Compositions and methods related to transgenic high oleic acid/ALS inhibitor-tolerant soybean plants are provided. Specifically, the present invention provides soybean plants having a DP-305423-1 event which imparts a high oleic acid phenotype and tolerance to at least one ALS-inhibiting herbicide. The soybean plant harboring the DP-305423-1 event comprises genomic/transgene junctions having at least the polynucleotide sequence of SEQ ID NO:8, 9, 14, 15, 20, 21, 83 or 84. The characterization of the genomic insertion site of the DP-305423-1 event provides for an enhanced breeding efficiency and enables the use of molecular markers to track the transgene insert in the breeding populations and progeny thereof. Various methods and compositions for the identification, detection, and use of the soybean DP-305423-1 events are provided. |
| US08609931B2 |
Polypeptides having beta-glucosidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. |
| US08609930B1 |
Maize variety hybrid X08A122
A novel maize variety designated X08A122 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X08A122 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X08A122 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X08A122, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X08A122. This invention further relates to is methods for producing maize varieties derived from maize variety X08A122. |
| US08609924B2 |
Ethylene tetramerization catalyst systems and method for preparing 1-octene using the same
Disclosed herein is a method of preparing 1-octene at high activity and high selectivity while stably maintaining reaction activity by tetramerizing ethylene using a chromium-based catalyst system comprising a transition metal or a transition metal precursor, a cocatalyst, and a P—C—C—P backbone structure ligand represented by (R1)(R2)P—(R5)CHCH(R6)—P(R3)(R4). |
| US08609921B1 |
Aromatic transalkylation using UZM-44 aluminosilicate zeolite
A new family of aluminosilicate zeolites designated UZM-44 has been synthesized. These zeolites are represented by the empirical formula. NanMmk+TtAl1-xExSiyOz where M represents a metal or metals from zine, Group 1, Group 2, Group 3 and or the lanthanide series of the periodic table, “m” is the mole ratio of M to (Al+E), T is the organic structure directing agent or agents, and E is a framework element such as gallium. UZM-44 may be used to catalyze a process for the transalkylation of a feedstream comprising one or more of C7, C9, C10 and C11+ aromatics to obtain a transalkylation product stream having an increased concentration of C8 aromatics relative to that of the feedstream. |
| US08609920B1 |
UZM-44 aluminosilicate zeolite
A new family of aluminosilicate zeolites designated UZM-44 has been synthesized. These zeolites are represented by the empirical formula. NanMmk+TtAl1-xExSiyOz where “n” is the mole ratio of Na to (Al+E), M represents a metal or metals from zinc, Group 1, Group 2, Group 3 and or the lanthanide series of the periodic table, “m” is the mole ratio of M to (Al+E), “k” is the average charge of the metal or metals M, T is the organic structure directing agent or agents, and E is a framework element such as gallium. These zeolites are similar to IM-5 but are characterized by unique compositions and synthesis procedures and have catalytic properties for carrying out various hydrocarbon conversion processes and separation properties for carrying out various separations. |
| US08609919B1 |
Aromatic transformation using UZM-44 aluminosilicate zeolite
A new family of aluminosilicate zeolites designated UZM-44 has been synthesized. These zeolites are represented by the empirical formula. NanMmk+TtAl1−xExSiyOz where “n” is the mole ratio of Na to (Al+E), M represents a metal or metals from zinc, Group 1, Group 2, Group 3 and or the lanthanide series of the periodic table, “m” is the mole ratio of M to (Al+E), “k” is the average charge of the metal or metals M, T is the organic structure directing agent or agents, and E is a framework element such as gallium. UZM-44 may be used to catalyze an aromatic transformation process by contacting a feed comprising at least a first aromatic with UZM-44 at hydrocarbon conversion conditions to produce at least a second aromatic. |
| US08609918B2 |
Method of producing para-substituted aromatic hydrocarbon
This invention relates to a method of efficiently producing a high-purity para-substituted aromatic hydrocarbon while suppressing caulking without requiring isomerization-adsorption separation steps, and more particularly to a method of producing a para-substituted aromatic hydrocarbon, characterized in that a methylating agent and an aromatic hydrocarbon are reacted in the presence of a catalyst formed by coating MFI type zeolite having a particle size of not more than 100 μm with a crystalline silicate. |
| US08609915B2 |
Processes for preparing alkylated aromatic compounds
Processes for preparing alkylation aromatic compounds are provided herein. In an embodiment, a process for preparing alkylated aromatic compounds includes reacting an aromatic compound and an olefin in a first alkylation reaction in the presence of a first alkylation catalyst to produce a first effluent that includes an alkylated aromatic compound and unreacted aromatic compound. Unreacted aromatic compound from the first effluent and additional olefin are reacted in at least one downstream alkylation reaction in the presence of a second alkylation catalyst to produce a second effluent including the alkylated aromatic compound. A recycle stream including the alkylated aromatic compound is recycled from the second effluent to the at least one downstream alkylation reaction and, optionally, the first alkylation reaction. A ratio of the recycle stream to a total mass flow is greater in the at least one downstream alkylation reaction than in the first alkylation reaction. |
| US08609914B2 |
Process for converting natural gas to aromatics with electrochemical removal of hydrogen
The present invention relates to a process for converting aliphatic hydrocarbons having 1 to 4 carbon atoms to aromatic hydrocarbons in the presence of a catalyst under nonoxidative conditions, wherein at least some of the hydrogen formed in the conversion electrochemically removed is by means of a gas-tight membrane-electrode assembly. |
| US08609913B2 |
Multi-zone fixed-bed or moving-bed reactor with an integrated heat exchanger
An axial flow staged zone oligomerization reaction process includes the steps of passing a hydrocarbon feedstock into the lower portion of the axial flow staged zone reactor which includes axial circulation of the hydrocarbon reaction fluid serially in each of the reaction zones, passing catalyst through a constriction zone located between successive upper and lower catalytic reaction zones which includes heat exchanging of the fluids being the constriction zone within the reactor and further includes withdrawing the oligomerized product from the top of the reactor. |
| US08609912B2 |
Processing of feedstocks in separated reactor volumes
Separated volumes can be created in a reactor using interior dividing wall or interior conduit structures. Feedstocks can be hydroprocessed in the separated volumes to allow multiple types of hydroprocessing conditions and/or feeds to be processed in a single reactor. The feedstocks can remain separate for the entire volume of the reactor, or the dividing barrier can end at some intermediate point in the reactor. |
| US08609903B2 |
Process for preparing hydroxy-substituted aromatic aldehydes
The present invention therefore relates to a process for preparing an aldehyde of the formula (I) where one, two or all three radicals from the group of R1, R3 and R5 are hydroxyl, and that radical or those radicals from the group of R1, R3 and R5 which are not hydroxyl are each independently hydrogen, C1-C8-alkyl or C6-C14-aryl, and R2 and R4 are each independently hydrogen, C1-C8-alkyl, C1-C8-alkoxy or C6-C14-aryl, which comprises converting an aldehyde of the formula (II) in which one, two or all three radicals from the group of R′1, R′3 and R′5 are C1-C8-alkoxy, and that radical or those radicals from the group of R′1, R′3 and R′5 which are not C1-C8-alkoxy are each independently hydrogen, C1-C8-alkyl or C6-C14-aryl, and R2 and R4 are each as defined for formula (I), at elevated temperature and elevated pressure in the presence of (C1-C4-alkyl)2-amine, and then isolating the reaction product of the formula (I). |
| US08609902B2 |
Organoactinide-, organolanthanide-, and organogroup-4-mediated hydrothiolation of terminal alkynes with aliphatic, aromatic and benzylic thiols
An efficient and highly Markovnikov selective organoactinide-, organolanthanide-, and organozirconium-catalyzed addition of aryl, benzyl, and aliphatic thiols to terminal alkynes is described. The corresponding vinyl sulfides are produced with little or no side-products. |
| US08609901B2 |
Highly selective process for producing organodiphosphites
Disclosed is a method for making a diphosphite of Structure I, |
| US08609899B2 |
Process for preparing toluenediamine by hydrogenation of dinitrotoluene
The invention relates to a process for the continuous preparation of toluenediamine by liquid-phase hydrogenation of dinitrotoluene by means of hydrogen in the presence of a suspended, nickel-comprising catalyst in a reactor with a product isolation unit downstream of the reactor to give a product output from the reactor comprising a liquid phase comprising toluenediamine and dinitrotoluene, in which the nickel-comprising catalyst is suspended, wherein the concentration of dinitrotoluene in the liquid phase of the product output from the reactor in the region between the reactor and the downstream product isolation unit is set to a value in the range from 1 to 200 ppm by weight, based on the total weight of the liquid phase of the product output from the reactor. |
| US08609897B2 |
Trifluoromethylsulfonamide gamma secretase inhibitor
The present invention is directed to a novel trifluoromethylsulfonamide derivative which inhibits the processing of APP by the putative γ-secretase and thus is useful in the treatment or prevention of Alzheimer's disease. This compound possesses favorable pharmacokinetic properties in higher species (rhesus) and thus can be dosed on an intermittent dosing regiment (e.g., once weekly). When dosed on such a regiment the compound exhibits significant and continuous Aβ lowering without the manifestation of Notch associated gastrointestinal toxicity for extended periods, e.g., 7 days. Pharmaceutical compositions and methods of use are also included. |
| US08609893B2 |
Process for manufacturing acrolein and/or acrylic acid from glycerol
The present invention relates to the manufacture of bioresourced acrolein and bioresourced acrylic acid from glycerol as starting material and more particularly comes within the scope of a process for the manufacture of acrolein and acrylic acid according to which the reaction for the dehydration of glycerol to give acrolein is carried out and the organic compounds which are heavier than water liable to be present in the various streams of the process arc removed, so as to obtain a stream which can be recycled to the dehydration stage without accumulation of heavy impurities, while minimizing the consumption of water and the discharge of polluted aqueous streams. |
| US08609888B2 |
Phosphonic acid compounds as inhibitors of serine proteases
The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders. |
| US08609886B2 |
Method for producing high purity terminal olefin compound
An industrially advantageous method for producing a high purity terminal olefin is disclosed, comprising the steps of (a) contacting a mixture comprising a terminal olefin represented by formula (1): and one or more corresponding internal olefins as impurities, with a brominating agent in the presence of water or an alcohol, to convert the internal olefin(s) to compound(s) having a higher boiling point than the terminal olefin; and (b) purifying the terminal olefin by distillation from the reaction mixture. |
| US08609881B2 |
Cure accelerators for anaerobic curable compositions
The present invention provides compound(s) selected from the group of compounds represented by structural Formula (I): wherein X, Y and R1 are as described herein, use of such compounds as anaerobic cure accelerators, and compostions including such compounds. |
| US08609879B2 |
Method for the separation of acetonitrile from water
A method for separating acetonitrile from water, comprising (i) providing a stream S1 containing at least 95 wt.-%, based on the total weight of S1, acetonitrile and water, wherein the weight ratio of acetonitrile: water is greater than 1; (ii) adding a stream P, comprising at least 95 wt.-% C3, based on the total weight of stream P, to S1 to obtain a mixed stream S2, C3 being propene optionally admixed with propane with a minimum weight ratio of propene: propane of 7:3; (iii) subjecting S2 to a temperature of 92° C. at most and a pressure of at least 10 bar, obtaining a first liquid phase L1 essentially consisting of C3, acetonitrile, and water, and a second liquid phase L2 essentially consisting of water and acetonitrile wherein the weight ratio of acetonitrile: water in L2 is less than 1; (iv) separating L1 from L2. |
| US08609876B2 |
9,10,12-triacyloxy octadecanoic acid alkyl ester and 9,10,12-triacyloxy octadecanoic acid alkyl ester rich fatty acid alkyl esters mixture and a process for preparation thereof
The present invention relates to modification of the chemical structure of ricinoleic acid, which is present to an extent of 85-90% in castor oil into triacyloxy alkyl ester derivatives. Accordingly, 9,10,12-trihydroxy octadecanoic acid rich fatty acid mixture was prepared from castor oil and converted to their alkyl esters followed by acylation of hydroxy groups to get 9,10,12-triacyloxy octadecanoic acid alkyl ester rich fatty acid alkyl esters mixture. The 9,10,12-triacyloxy octadecanoic acid alkyl esters were purified from the crude product and characterized by 1H NMR studies. The crude products were also evaluated for acid value (A.V.), hydroxyl value (H. V.), iodine value (I. V.), viscosity, viscosity index (V.I.), pour point, flash point and copper strip corrosion and found to be potential base stocks for hydraulic, metal working fluids and other industrial fluids. |
| US08609872B2 |
Method for preparing diahydrohexitol diester compositions
A dianhydrohexitol diester composition is obtained by esterifying a dianhydrohexitol composition with a carboxylic acid in the presence of an acid catalyst and hypophosphorous acid. Preferably, the hypophosphorous acid is introduced in an amount between 0.05 and 2 wt. percent of dianhydrohexitol, and in a hypophosphorous acid/acid catalyst weight ratio of less than 1/1. Dianhydrohexitol diester compositions, for example isosorbide diesters, isomannide and/or isoidide rich in diester(s), and having a low yellow index (YI), are useful in numerous industrial applications, in particular in plastic compositions. |
| US08609868B2 |
Process for preparing dithiine-tetracarboxy-diimides
The present invention relates to a new process for preparing dithiine-tetracarboxy-diimides. |
| US08609865B2 |
Crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid
The present invention relates to a novel crystals of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid and methods of making the zwitterion of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid. |
| US08609861B1 |
Hexaaza [3.3.3] propellane compounds as key intermediates for new molecular explosives and a method for preparing the same
Provided are hexaaza[3.3.3]propellane compounds represented by the following formula (I), which can be used as a main skeleton structure for novel molecular explosives and method for preparing the same: wherein, R is H, C1-C20 alkyl, cycloalkyl, arylalkyl or aryl, which may contain heteroatoms such as oxygen, nitrogen, sulfur, halogen, etc. or unsaturations; and X is H2, O or S. |
| US08609860B2 |
Acid-labile trigger units
The present invention relates to a compound comprising an imine bond as an acid-labile trigger group, the use of such an imine bond as an acid-labile trigger group, a process of cleaving the imine bond in said compound, and a pharmaceutical composition comprising said compound. |
| US08609852B2 |
Thiazolyl mGluR5 antagonists and methods for their use
The identification of a unique series of compounds which possesses special advantages in terms of drug-like properties due to their possessing advantageous properties in terms of potency and/or pharmacokinetic and/or selectivity and/or in vivo receptor occupancy properties. Specifically, the selection of a 1,3-thiazol-2-yl ring member linked by an ethynylene to the 3 position of a pyridyl ring or the 5 position of a pyrimidinyl ring, wherein the ring is substituted with selected substituents, results in a compound having superior drug-like properties. The invention includes pharmaceutically acceptable salt forms of these heterocyclic compounds, in particular chloride salts and trifluoroacetate salts. |
| US08609850B2 |
Targeted nitroxide agents
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation. |
| US08609842B2 |
Method for synthesizing Imatinib
In the present invention, a synthesis method of Imatinib is disclosed, which comprises the following steps: the Imatinib, namely 4-(4-methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-[4-(3-pyridinyl)-pyrimidin-2-ylamino]-benzami de shown in formula (III), is formed by reacting 4-methyl-N-3-(4-pyridin-3-yl-pyrimidin-2-yl)-1,3-benzenediamine shown in formula (I) with 4-(4-methyl-piperazin-1-methyl)-benzoic ester shown in formula (II), under the action of a base and in a non-protonic organic solvent, in the above generic chemical structural formula, R represents aliphatic alkyl having 1-10 carbon, phenyl, substituted phenyl, benzyl or substituted benzyl. The present invention provides a new synthesis method of Imatinib, which is formed under mild reaction conditions, and is environmentally friendly with a high-yield. |
| US08609839B2 |
Camphor-derived compounds, method for manufacturing the same, and application thereof
Camphor-derived compounds are disclosed, which are represented as the following formula (I): wherein R1, R2, R3, and R4 each are defined as described in the specification. In addition, a method for manufacturing the camphor-derived compounds and application thereof are disclosed. |
| US08609835B2 |
Polysaccharide composition and methods of isolation of the emulsion stabilizing cationic polyelectrolytic polysaccharide
The present invention relates to purification and use of a novel emulsion stabilizing polysaccharide. In particular, a polyelectrolyte exopolysaccharide with high molecular weight comprising a high molecular weight polymer with a tri-saccharide repeating unit is disclosed. In one aspect of the invention, methods are directed to isolating and purifying a high molecular weight exopolysaccharide (EPS) from a cell supernatant. In another aspect, methods are disclosed for isolating a lipopolysaccharide (LPS) and a high molecular weight Acinetobacter polyelectrolyte exopolysaccharide (APE) from Acinetobacter bacteria. Compositions are also directed to lipid nanoparticles comprising a therapeutic agent encapsulated by a high molecular weight polysaccharide and nanoparticles comprising a therapeutic agent bound to a cationic polysaccharide cross-linked with a polyanion. |
| US08609832B2 |
Methods and products for expression of micro RNAs
The invention relates to microRNAs, methods of producing microRNAs and methods for using microRNAs. |
| US08609829B2 |
Compositions and methods to detect Legionella pneumophila nucleic acid
Compositions are disclosed as nucleic acid sequences that may be used as amplification oligomers, including primers, capture probes for sample preparation, and detection probes specific for Legionella pneumophila 16S or 23S rRNA sequences or DNA encoding 16S or 23S rRNA. Methods are disclosed for detecting the presence of L. pneumophila in samples by using the disclosed compositions in methods that include in vitro nucleic acid amplification of a 16S rRNA sequence or DNA encoding the 16S rRNA sequence, or of a 23S rRNA sequence or DNA encoding the 23S rRNA sequence to produce a detectable amplification product. |
| US08609828B2 |
Oligonucleotides and methods for detection of West Nile virus
The invention provides methods of detecting West Nile virus and oligonucleotide reagents derived from a West Nile virus consensus sequence that are useful in the methods of the invention. |
| US08609826B2 |
RNA-selective hybridization reagent and use of the same
Provided is a nucleoside derivative which has a high affinity for RNA. Use is made of a nucleoside derivative represented by either formula (1) or formula (2). (In formulae (1) and (2), Z represents a carbon atom or a nitrogen atom; R1 represents a hydrogen atom or a hydroxyl-protecting group; and R2 represents a hydrogen atom or a phosphodiester group). |
| US08609822B2 |
Neutralizing antibodies and methods of use thereof
This invention provides monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, and monoclonal antibodies that recognize the TLR4/MD2 complex as well as TLR4 when not complexed with MD-2. The invention further provides methods of using the humanized monoclonal antibodies as therapeutics. This invention also provides soluble chimeric proteins, methods of expressing and purifying soluble chimeric proteins, and methods of using soluble chimeric proteins as therapeutics, in screening assays and in the production of antibodies. |
| US08609821B2 |
Antibodies against APRIL as biomarkers for early prognosis of lymphoma patients
The invention relates to antibodies directed against APRIL (A Proliferation Inducing TNF Ligand, also known as TALL-2), in particular the monoclonal antibody Aprily-2, hybridoma cells producing monoclonal antibody Aprily-2, and the use of a combination of an antibody against membrane-anchored APRIL and Aprily-2 in the diagnosis of B cell lymphoma resistance to treatment and the prognosis of clinical development of Diffuse Large B-Cell (DLBCL) lymphoma from high risk patients (>60 years and International Prognostic Index >2). An amino acid sequence GTGGPSQNGEGYP called Stalk, useful in the preparation of antibodies, is described. |
| US08609817B2 |
Anti-hepcidin-25 selective antibodies and uses thereof
Monoclonal antibodies are provided that bind to the N-terminus of human hepcidin-25 and are characterized as having high affinity and selectivity for the polypeptide. The antibodies of the invention are useful for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment of various disorders, such as anemia, in a human subject. The antibodies of the invention are also useful as analytical tools, such as in sandwich ELISA. |
| US08609814B2 |
Modified globin proteins with altered electron transport pathway
The present invention relates to a modified porphyrin-based oxygen-carrying protein, such as haemoglobin, which has been found, in its unmodified state to have a low affinity site of electron transfer and a high affinity electron transfer between a reductant and ferryl haem iron via one or more protein amino acids. The invention provides such proteins that comprise a modification to enhance this pathway. |
| US08609805B2 |
Copolyether glycol manufacturing process
The present invention provides a highly efficient process for manufacturing copolyether glycol having a mean molecular weight of from about 650 to about 5000 dalton by polymerization of tetrahydrofuran and at least one alkylene oxide in the presence of an acid catalyst and at least one compound containing reactive hydrogen atoms. More particularly, the invention relates to a process for manufacturing copolyether glycol which comprises recycle to the polymerization reaction step of at least a portion of the oligomeric cyclic ether which is co-produced with the copolyether glycol, said process exhibiting an Space Time Yield value of greater than about 0.9. |
| US08609803B2 |
Organic semiconductor compound, and organic thin film including the organic semiconductor compound
An organic semiconductor compound may be represented by the above Chemical Formula 1 or Chemical Formula 2, and an organic thin film may include the organic semiconductor compound according to Chemical Formula 1 or 2. |
| US08609802B2 |
Production method for a wholly aromatic liquid crystalline polyester resin, a wholly aromatic liquid crystalline polyester resin produced by means of the method, and a compound of the wholly aromatic liquid crystalline polyester resin
Disclosed are a production method for a wholly aromatic liquid crystalline polyester resin, a wholly aromatic liquid crystalline polyester resin produced using the method, and a compound of the wholly aromatic liquid crystalline polyester resin. The disclosed production method for a wholly aromatic liquid crystalline polyester resin comprises the steps of synthesizing a wholly aromatic liquid crystalline polyester resin by synthesizing a wholly aromatic liquid crystalline polyester prepolymer by a condensation polymerization of a monomer and then reducing the pressure inside a reaction vessel containing the synthesized prepolymer at a predetermined internal pressure reduction rate of the reaction vessel. |
| US08609799B2 |
Method of forming functionalized silanes
Heteroatom doped silane compounds, e.g., phosphorus-containing silane compounds, are provided. The application also provides methods of producing the heteroatom doped silane compounds from halogen substituted silanes via reaction with a heteroatom-containing nucleophile. |
| US08609796B2 |
Method for chemically producing poly(N-alkylcarbazole) columnar structure
A novel nanosized or microsized material having electroconductivity that can be produced simply and in a large amount is provided. A method for producing a poly(N-alkylcarbazole) columnar structure having electroconductivity obtained by chemically polymerizing N-alkylcarbazole including alkyl having 1 to 4 carbons by adding an oxidizing agent to a solution obtained by dissolving the N-alkylcarbazole in a solvent is provided. |
| US08609795B2 |
Water and oil repellent composition
A water and oil repellent composition having excellent durability, which can impart excellent water and oil repellency to an object, even in a process at low temperatures, and which enables water and oil repellent treatment providing a soft hand. A water and oil repellent composition which comprises, as an essential component, a copolymer containing polymerization units of the following monomer (a) and polymerization units of the following monomer (b): monomer (a): an Rf group-containing monomer which forms a photopolymer having no melting point or a melting point of at most 55° C. attributable to fine crystals derived from the Rf groups and having a glass transition point of at least 20° C. monomer (b): a monomer having no Rf group and having a cross-linkable functional group. |
| US08609794B2 |
Process for selectively polymerizing ethylene and catalyst therefor
The present invention generally relates to a process that selectively polymerizes ethylene in the presence of an alpha-olefin, and to a metal-ligand complex (precatalyst) and catalyst useful in such processes, and to related compositions. The present invention also generally relates to ligands and intermediates useful for preparing the metal-ligand complex and to processes of their preparation. |
| US08609793B2 |
Catalyst systems containing a bridged metallocene
The present invention provides polymerization processes utilizing a catalyst system containing an ansa-metallocene and a second metallocene compound for the production of olefin polymers. |
| US08609776B2 |
Unsaturated polyester-urethane prepolymer and its applications
An ethylenically unsaturated prepolymer comprising an ending X which reacts by condensation being a hydroxyl and/or amine or free isocyanate group and optionally an ending X′ having ethylenic unsaturation, the prepolymer being the reaction product of a first component A comprising a mixture of i) a first ethylenically unsaturated resin carrying specific hydroxyl and/or amine reactive endings, and/or ii) optionally a second resin different from resin i), being an ethylenically unsaturated hydroxylated resin and/or a hydroxylated and/or aminated saturated resin, and/or iii) optionally a third reactive saturated resin, iv) optionally an unsaturated monoalcohol up to 30% in equivalents of the OH+NH2 total, and a second component B comprising a polyisocyanate with a functionality equal to 2 or greater than 2, A and B being in proportions to effectively avoid any gelling by crosslinking. |
| US08609774B2 |
Belt
The present invention provides a belt excellent in mechanical properties at high temperatures. The belt of the present invention comprises a cross-linked fluororubber layer obtainable by cross-linking a fluororubber composition containing a fluororubber (A) and a carbon black (B). The cross-linked fluororubber layer has a loss modulus E″ of 400 kPa or higher and 6,000 kPa or lower determined by a dynamic viscoelasticity test (measurement temperature: 160° C., tensile strain: 1%, initial force: 157 cN, frequency: 10 Hz). |
| US08609772B2 |
Elastic films having improved mechanical and elastic properties and methods for making the same
A film comprising one or more propylene-based polymers, one or more hydrocarbon resins, and one or more polyolefin additives provides enhanced mechanical and elastic properties compared to the neat propylene-based polymer. The propylene-based polymer may have (i) 60 wt % or more units derived from propylene; and (ii) crystallinity of from 0.25% to 40%, resulting from isotactically arranged propylene-derived sequences. The hydrocarbon resin may have a glass transition temperature greater than 20° C. The polyolefin additive may have a crystallinity greater than the crystallinity of the propylene-based polymer. Methods for making and using the films are also described. |
| US08609768B2 |
Hot melt adhesive composition
A hot melt adhesive composition employing a thermoplastic polyurethane, which has a high adhesive strength even under bonding conditions of low temperature and short time or even to nylon cloth, and which has a favorable adhesive strength in a wide temperature range of from room temperature to low temperature. A hot melt adhesive composition comprising a thermoplastic polyurethane (A) having a flow initiation temperature of from 80 to 150° C. and a phenolic hydroxy group-containing compound (B) having phenolic hydroxy groups and having a molecular weight of at least 1,000. |
| US08609767B2 |
Thermosetting resins with gelled nanometer-sized rubber particles
Toughened thermosetting resins comprising thermosetting resins and rubber particles having an average particle size in the range of 20 to 500nm. The toughened resins are obtained by mixing a fully vulcanized powdery rubber having an average particle size in the range of 20 to 500nm with thermosetting resin prepolymers and then curing them. The toughened thermosetting resins comprise rubber phases having a small, uniform and stable particle size, which results in a very significant toughening effect, especially when crazes rapidly grow (as in a standard Izod impact test). The toughened thermosetting resins are excellent in impact resistance, strength, modulus and heat resistance, and when appropriately toughened, the thermosetting resins can be enhanced in terms of impact strength, glass transition temperature and heat distortion temperature. The toughened thermosetting resins are useful for many application areas and the method for preparing the same can be carried out in a simple and easy manner and is suitable for toughening various thermosetting resins. |
| US08609763B2 |
Resin composition for vibration damping material and vibration damping material
A resin composition for vibration damping material for a vibration damping material exhibiting high vibration damping performance in a wider temperature range and a vibration damping material using the same are provided. The resin composition contains 100 parts by weight of a resin component A as a matrix and 5 to 300 parts by weight of a resin component B dispersed in the matrix. The resin component B has two or more cyclic structures selected from the group consisting of an aromatic hydrocarbon group, an aliphatic cyclic hydrocarbon group, and a heteroaromatic group, and is in a glassy state at use temperature. |
| US08609758B2 |
Pneumatic article provided with a self-sealing composition
An inflatable article such as a pneumatic tire provided with a puncture-resistant layer comprising, by way of a self-sealing composition, an elastomer composition comprising at least, as predominant elastomer, a thermoplastic styrene (TPS) elastomer, more than 200 phr of an extender oil and more than 20 phr of a hydrocarbon resin, the glass transition temperature of which is greater than 0° C. The puncture-resistant layer is advantageously combined with an airtight layer, for example based on butyl rubber, so as to form, in the pneumatic article, an airtight puncture-resistant laminate. |
| US08609750B1 |
Selective clay placement within a silicate-clay epoxy blend nanocomposite
A clay-epoxy nanocomposite may be prepared by dispersing a layered clay in an alkoxy epoxy, such as a polypropylene oxide based epoxide before combining the mixture with an aromatic epoxy to improve the nanocomposite's thermal and mechanical properties. |
| US08609749B1 |
Method for preparing a polyurethane-carbon nanotube based coating composition
The invention provides a method for preparing a Polyurethane-Carbon Nanotube (PU-CNT) based coating composition. More specifically, the invention provides a method for preparing a PU-CNT based anti-corrosive coating composition. The method comprises preparing a dispersion comprising one or more types of Carbon Nanotubes (CNTs). The dispersion is prepared by dispersing the one or more types of CNTs in a dispersant comprising at least one polar solvent and at least one surfactant. The method further comprises mechanically mixing a hardener with the dispersion comprising the one or more types of CNTs. In addition, the method comprises mechanically mixing polyurethane with the dispersion prepared by mechanically mixing the hardener with the dispersion comprising the one or more types of CNTs. |
| US08609748B2 |
Modified perovskite type composite oxide, method for preparing the same, and composite dielectric material
Provided is a modified perovskite type composite oxide in which the dielectric characteristics are equal to or better than those prior to modification, there is no substantial elution of coating components from the modifying coating components, and change in the specific surface areas over time and elution of the A-site metals are suppressed effectively, while the cracking traits are good. A modified perovskite type composite oxide in which the particle surface of a perovskite type composite oxide is coated with a first component of at least one selected from TiO2 and SiO2 and a second component of at least one selected from a group consisting of Al, Zr, Nd, La, Ce, Pr, and Sm, wherein the coating is formed by hydrolyzing at least one selected from a hydrolyzable TiO2 precursor and a hydrolyzable SiO2 precursor as a source of the first component and a salt of at least one selected from a group consisting of Al, Zr, Nd, La, Ce, Pr, and Sm as a source of the second component, and then calcining them. |
| US08609734B2 |
Methods of treating pain with MGBG
Disclosed herein are new oral pharmaceutical compositions of MGBG and related polyamine analogs, polyamine biosynthesis inhibitors, polyamine inhibitors of AMD-I and regulators of osteopontin, and their application for the treatment of disease. |
| US08609727B2 |
Dicarboxylic acid derivatives and their use
The present application relates to novel dicarboxylic acid derivatives, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders. |
| US08609725B2 |
Method of using beta-hydroxy-beta-methylbutyrate for reducing tumor growth rate
The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids. |
| US08609724B2 |
Method of treating cancer using dichloroacetate
The invention relates to the use of dichloroacetate and chemical equivalents thereof for the treatment of cancer by inducing apoptosis or reversing apoptosis-resistance in a cell Preferably, the dosage is 10-100 mg/kg Preferably, sodium dichloroacetate is used. The dichloroacetate may optionally be given in combination with a pro-apoptotic agent and/or a chemotherapeutic agent Preferably, the cancers treated are non-small cell lung cancer, glioblastoma and breast carcinoma. |
| US08609723B2 |
Long acting curcumin derivative, preparation method and pharmaceutical use thereof
The invention provides a long acting curcumin derivative, preparation method and pharmaceutical use thereof, wherein said long acting curcumin derivative having the general structural formula disclosed herein, wherein R1 and R2 are hydrogen or methoxyl; R3 and R4 are each independently selected from C1-C50 alkyl. Compared with cuminoids, the inventive long acting curcumin derivative has a better release effect, a higher bioavailability and pharmaceutical activity, and thus can be useful for the treatment of diseases such as depression and cancer. |
| US08609721B2 |
Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention. |
| US08609719B2 |
Propargylated aminoindans, processes for preparation, and uses thereof
A method for treating an individual who has been identified as having Alzheimer's disease by administering orally to the individual a therapeutically effective amount of ladostigil or a pharmaceutically active salt thereof, wherein the therapeutically effective amount is 70 mg per day, 140 mg per day, or 200 mg per day. Also, a unit dosage form of ladostigil or a pharmaceutically active salt thereof in an amount of 50 mg, 70 mg, 80 mg or 100 mg. |
| US08609718B2 |
Pharmaceutical composition used in treatment of hyperproliferative skin conditions and malignant melanomas comprising pachastrissamine as active ingredient
Disclosed is a novel use of phytosphingosine. More particularly, disclosed are a composition for preventing or treating hyper-proliferative skin diseases comprising pachastrissamine as an active ingredient, a use of pachastrissamine or a pharmaceutically acceptable salt thereof for preparing a preventing/therapeutic agent of hyper-proliferative skin diseases, and a method for treating hyper-proliferative skin diseases administering an effective amount of pachastrissamine or a pharmaceutically acceptable salt thereof to a subject in need thereof. The pachastrissamine inhibits the degradation of FoxO3a protein and increases the expression of FoxO3a protein. Thus, the inventive pharmaceutical composition has a preventing of treating effect on hyper-proliferative diseases by inducing apoptosis of hyper-proliferative cells and inhibiting the cell cycle. Accordingly, the disclosed composition, a use, and the method can be used for preventing or treating various hyper-proliferative skin diseases such as skin cancer or psoriasis. |
| US08609717B2 |
β- and γ-diketones and γ-hydroxyketones as WNT/β-catenin signaling pathway activators
The present invention discloses β-diketones, γ-diketones or γ-hydroxyketones or analogs thereof, that activate Wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, comprising hair loss, hematopoiesis related diseases and tissue regeneration related diseases. |
| US08609715B2 |
Heteroarylcarboxylic acid ester derivative
Compounds represented by formula (I): wherein each symbol is as defined in the description, and pharmaceutically acceptable salts thereof are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes. |
| US08609706B2 |
Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer. |
| US08609701B2 |
Pirfenidone treatment for patients with atypical liver function
Methods are provided for administering pirfenidone to a patient that has exhibited abnormal biomarkers of liver function in response to pirfenidone administration. The methods include administering to a patient pirfenidone at doses lower than the full target dosage for a time period, followed by administering to the patient pirfenidone at the full target dosage. The methods also include administering pirfenidone at the full target dose with no reduction and administering permanently reduced doses of pirfenidone. |
| US08609700B2 |
Pyridine compounds for controlling invertebrate pests I
The present invention relates to novel pyridine compounds of the formulae I and II, to their salts, to their tautomers, to their N-oxides, and to the salts of these N-oxides or tautomers. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests. The invention also relates to a method for controlling invertebrate pests by using these compounds. The invention further relates to plant propagation material and to agricultural compositions comprising said compounds. wherein A is a radical of the formulae A1 or A2 # denotes the binding site to the remainder of formulae I or II; n is 0, 1, 2 or 3; Z is O, S or N—RN; X1 is S, O or NR1a; X2 is OR2a, NR2bR2c, S(O)mR2d; X3 is a lone pair or oxygen; R1, R2 and R3 are, inter alia, hydrogen, and RA and RN, are as defined in claim 1. |
| US08609691B2 |
Cyclohexylamin isoquinolone derivatives
The invention relates to 6-cyclohexylamine-substituted isoquinolone derivatives of the formula (I) or isoquinoline derivatives of the formula (I′) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds. |
| US08609688B2 |
Substituted imidazopyridinyl-aminopyridine compounds
The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof. |
| US08609687B2 |
Triazolopyridine JAK inhibitor compounds and methods
A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed. |
| US08609682B2 |
Analgesic agents
The invention provides a compound of formula (I) or a salt thereof, as well as compositions comprising such compounds. The compounds and compositions are useful as analgesics. |
| US08609681B2 |
Spirocyclic nitriles as protease inhibitors
The invention relates to substituted carbo- and heterocyclic spiro compounds of the formula Ia which inhibit thiol proteases, to processes for their preparation and to the use thereof as medicaments. |
| US08609679B2 |
2,4-diaminopyrimidines useful as kinase inhibitors
The present invention provides 2,4-diaminopyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods of using the same. |
| US08609675B2 |
Fused Tricyclic Compounds as novel mTOR inhibitors
The present invention provides Fused Tricyclic Compounds of the Formula (I) wherein Q, R1, R2, R3, and R4 are as defined herein, and pharmaceutically acceptable salts of such Fused Tricyclic Compounds. The Fused Tricyclic Compounds are useful in the treatment of cancer and other proliferative disorders. |
| US08609673B2 |
Vandetanib derivatives
This invention relates to novel quinazoline derivatives of the formula: wherein each variable is as defined herein, and their acceptable acid addition salts. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by inhibitory activity against the VEGF receptor tyrosine kinase. |
| US08609668B2 |
Substituted triazolo[1,5-A]pyrimidines as antiviral agents
A pharmaceutical composition comprising an effective amount of a compound of formulas (I-III) and a pharmaceutically acceptable carrier. Methods for treating a hepatitis virus in a patient comprising administering an effective amount of the compound of formulas (I-III) are also presented. |
| US08609666B2 |
2-morpholino-pyrido[3,2-D]pyrimidines
This invention relates to compounds of Formula (I) as Pi3k inhibitors for treating autoimmune diseases, inflammatory disorders, multiple sclerosis and other diseases like cancers. |
| US08609665B2 |
Solvate and crystalline forms of carbamoyl-cyclohexane derivatives
The present invention relates to novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives and, more particularly, to novel solvate and crystalline forms of trans-1{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-3,3-dimethyl-urea hydrochloride. Processes for the preparation of these forms, compositions containing these forms, and methods of use thereof are also described. |
| US08609664B2 |
Piperazinyl derivatives as modulators of chemokine receptor activity
The present application describes modulators of MIP-1α of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein m, T, W, R1, R4, R5, R5a and R5b are as defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using said modulators are disclosed. |
| US08609661B2 |
Pyrimido-pyrrolo-quinoxalinedione inhibitors of cystic fibrosis transmembrane conductance regulator protein and uses therefor
Provided herein are pyrimido-pyrrolo-quinoxalinedione (PPQ) compounds, and compositions comprising these compounds, that inhibit cystic fibrosis transmembrane conductance regulator (CFTR) mediated ion transport and that are useful for treating diseases and disorders associated with aberrantly increased CFTR chloride channel activity. The compounds, and compositions comprising the compounds, described herein are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased CFTR activity, for example, polycystic kidney disease. The compounds may be used for inhibiting expansion or preventing formation of cysts in persons who have polycystic kidney disease. |
| US08609659B2 |
Substituted 3,8-diazabicyclo[3.2.1]octane compounds
Diazapolycyclic compounds having affinity for the opioidergic receptors, preferably for the delta opioidergic receptors, with central and/or peripheral activity, having formula: A1-D1-T1 (I) wherein: A1 is a group of formula (II): wherein: R1 is phenyl wherein one of the ring hydrogen atoms is substituted with a group selected from C(O)R′, C(O)OR′, C(O)NHR′ or C(O)NR3R4, R′, R3 and R4, being as defined in the application; R2 is phenyl, optionally substituted D1 is a diazapolycyclic group T1 is a group selected from H, alkyl, alkenyl, alkynyl and from the following optionally substituted groups: cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl or heteroarylalkyl, and their hydrates and solvates and pharmaceutically acceptable salts. |
| US08609652B2 |
Method of administering a methylene blue-curcumin analog for the treatment of alzheimer's disease
A method of administering a methylene blue-curcumin hybrid useful in treating or preventing Alzheimer's Disease. |
| US08609649B2 |
Compositions and methods for the diagnosis, treatment, and prevention of amyotrophic lateral sclerosis and related neurological diseases
One aspect of the invention relates to a method of treating or preventing a neurodegenerative disease, comprising the step of administering to a patient in need thereof a therapeutically effective amount of an inhibitor of the formation of advanced glycation end products. Another aspect of the invention relates to a proteasome activity-based screening assay to select compounds which may be useful for treating or preventing a neurodegenerative disease, and the materials used therein. Yet another aspect of the invention relates to molecules, and methods of use thereof, which bind at or adjacent to SOD-I Trp32, including molecules that bind in a site adjacent to SOD-I Trp32 whether or not it is oxidized, for treating or preventing neurodegenerative disease. |
| US08609646B2 |
Enhanced erythropoiesis and iron metabolism
The present invention relates to methods and compounds for decreasing the expression of hepcidin, a protein associated with regulation of iron metabolism. |
| US08609639B2 |
Stat3 inhibitor having anti-cancer activity and methods
A small-molecule Stat3 dimerization inhibitor, S3I-M2001, is described and the dynamics of intracellular processing of activated Stat3 within the context of the biochemical and biological effects of the Stat3 chemical probe inhibitor are elucidated. S3I-M2001 is a newly-identified oxazole-based peptidomimetic of the Stat3 Src Homology (SH) 2 domain-binding phosphotyrosine peptide that selectively disrupts active Stat3:Stat3 dimers. Stat3-dependent malignant transformation, survival, and migration and invasion of mouse and human cancer cells harboring persistently-activated Stat3 were inhibited by S3I-M2001. S3I-M2001 inhibited Stat3-dependent transcriptional regulation of tumor survival genes, such as Bcl-xL. The disclosed compound is useful as a new potential treatment for certain cancers. |
| US08609637B2 |
Prodrugs of 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-(1H)-one and derivatives thereof
A prodrug can have a structure of Formula 10 or derivative thereof or stereoisomer thereof or pharmaceutically acceptable salt thereof. The prodrug can be included in a pharmaceutical composition for use in treatment of fungus, cancer, dermatitis, superficial mycoses; inflammation, tinea pedis, tinea cruris, and tinea corporis, Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis, candidiasis (moniliasis), Candida albicans, tinea (pityriasis) vesicolor, Malassezia furfur, acute myeloid leukemia, acute lymphoid leukemia, chronic myelogenous leukemia, lymphoma or multiple myeloma. |
| US08609634B2 |
Preserved compositions containing hyaluronic acid or a pharmaceutically-acceptable salt thereof and related methods
The invention provides a composition containing hyaluronic acid (HA) or a pharmaceutically-acceptable salt thereof preserved with a cationic preservative and related methods. In one embodiment, the pharmaceutically-acceptable salt is sodium hyaluronate. In another embodiment, the cationic preservative includes benzalkonium chloride (BAK). |
| US08609633B2 |
Core 2 GlcNAc-T inhibitors
A method of treating a subject in need of therapy for a condition involving detrimental activity of the enzyme core 2 GlcNAc-T is provided, comprising administration of a therapeutically effective amount of an inhibitor of core 2 GlcNAc-T of formula I to a patient in need thereof wherein: R1 is H, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 alkoxy or C1-6-alkoxy-C1-6-alkyl; R2 is H, —OH or C1-6 alkoxy; S1 and S2 are independently selected saccharide moieties; and Z is a steroid moiety; or a pharmaceutically acceptable salt, ether or ester thereof. |
| US08609630B2 |
Vitamin B12 compositions
This disclosure provides compositions of vitamin B12, and methods of treatment or amelioration of a disease associated with vitamin B12 deficiency. The composition can take the form of a solid, semi-solid, gummy, or chewable lozenge. The composition can also take the form of a troche, a candy, a wafer, an orally disintegrating tablet, a sublingual tablet, a buccal tablet, a buccal patch, an oral dissolvable film, an aerosol or spray, a lip balm, and chewing gum. |
| US08609626B2 |
NLK as a marker for diagnosis of liver cancer and as a therapeutic agent thereof
A novel marker for diagnosis of liver cancer and use thereof are provided. To be specific, a marker for diagnosis of liver cancer using over-expression of NLK (neuro-like kinase) in liver cancer cell is provided, along with a composition for diagnosis of liver cancer, a kit, a microarray, and a method for diagnosing liver cancer using the marker. Additionally, a method for screening a substance to prevent or treat liver cancer by decreasing expression of the marker gene or protein, and a composition for preventing or treating liver cancer including such substance are provided. Accordingly, the NLK gene can be efficiently used as a target for diagnosis and treatment of liver cancer. |
| US08609624B2 |
Methods and compositions for the inhibition of Stat5 in prostate cancer cells
The present invention relates to compositions and methods for the treatment of prostate cancer. In certain embodiments, the invention relates to compositions and methods for the inhibition of prostate cancer cell growth, comprising inhibiting the activity of Stat5 in prostate cancer cells. |
| US08609618B2 |
Topical palmitoyl glutathione formulations
A topical composition for application to aging skin, comprising an effective amount of S-acyl glutathione derivative of formula (I) wherein R1 consists of an unsaturated or saturated C16 group and R2 is a hydrogen, aliphatic or aromatic acyl group; and a dermatologically acceptable carrier. Preferred compositions comprise about 1.0% to about 3.0% by weight of S-palmitoyl glutathione. |
| US08609617B2 |
KLF family members regulate intrinsic axon regeneration ability
This invention relates, to a method for promoting CNS axon regeneration, comprising (1) inhibiting the expression or activity in a neuron of one or more of the members of the Krüppel-like transcription factor (KLF) family that suppress axon growth (e.g., KLF 1, 2, 3, 4, 5, 9,12, 13, 14, 15 and/or 16), and/or (2) stimulating the expression or activity in a neuron of one or more of the members of the KLF family that promote axon growth (e.g., KLF 6 and/or 7). |
| US08609616B2 |
Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions
A method for the treatment and/or prophylaxis of an osteonecrotic bone disease in a mammal in need thereof, such as, e.g., idiopathic or secondary osteonecrosis, avascular bone necrosis, glucocorticoid induced bone ischemia/osteonecrosis, Legg-Calve-Perthes disease and femoral head necrosis, the method comprising administering an effective dose of a strontium-containing compound (a) to the mammal. A method for the treatment and/or prophylaxis of an osteonecrotic bone disease, such as, e.g., idiopathic or secondary osteonecrosis, avascular bone necrosis, glucocorticoid induced bone ischemia/osteonecrosis and femoral head necrosis, in a mammal who is to be or is treated with a therapeutic agent (b) known to or suspected of inducing apoptosis and/or necrosis of bone cells, the method comprising administering a strontium-containing compound (a) in combination with (b). |
| US08609615B2 |
Methods and compositions for treatment of myotonic dystrophy
In certain embodiments, the present invention provides compositions and methods for treating myotonic dystrophy. |
| US08609611B2 |
Synthesis of small particles
The invention provides an apparatus for forming fine particles of a substance in a precipitation chamber, in which the apparatus has means to convey the fine particles from the precipitation chamber to at least one particle collection chamber, downstream of the precipitation chamber, the particle collection chamber having an inlet and an outlet separate from the inlet. The invention also provides a method of forming fine particles of a substance, the method comprising contacting a non-gaseous fluid containing the substance with a dense fluid to expand the non-gaseous fluid in a precipitation chamber, conveying a resulting mixture of fluid and the fine particles from the precipitation chamber to a collection chamber, the collection chamber having an inlet and an outlet separate from the inlet. |
| US08609606B2 |
Polypeptide acting to enhance ischemic diseases
Disclosed is a polypeptide of use in the development of reagents or medicines favourable to application for prevention or treatment of ischemic disorders such as conditions caused by ateriosclerosis. The polypeptide has at least one part containing an amino acid of sequence ID 1, and also enhances expression levels of the amino acid in mammalian blood vessels removed from ischemic conditions by means of blood reperfusion. |
| US08609602B2 |
Cleaning solution
Disclosed are cleaning solutions. More particularly, non-toxic solutions of base, water, alcohol and detergent, that effectively and surprisingly eliminate contaminating aliphatic acids in aqueous solutions. When present as a foam or even a contaminating film remaining on various parts and surfaces, aliphatic acid contaminants can be present a large and costly problem in manufacturing operations, cleaning tasks, personal hygiene. The need to remove such contaminants arises in a myriad environments and situations, such as during the manufacture of detergents, pharmaceuticals, consumer products, coring and core analysis, manipulation of oils, fuels, fermentation applications, manufacture of emollients, moisturizers, liquors, foods such as seafood, milk, butter and other dairy products, water processing, paper products, tissue culture, reusable clinical equipment, and the like. Presented are cleaning compositions and methods that effectively eliminate and prevent build up of such dangerous and costly contaminants in aqueous solutions. |
| US08609599B2 |
Marine engine lubrication
Trunk piston marine engine lubrication, when the engine is fueled by heavy fuel oil, is effected by a composition comprising a major amount of an oil of lubricating viscosity and a minor amount of one or more phenolic compounds comprising distilled cashew nut shell liquid or hydrogenated distilled cashew nut shell liquid. Asphaltene precipitation in the lubricant, caused by the presence of contaminant heavy fuel oil, is prevented or inhibited. |
| US08609597B2 |
Estolide compositions having excellent low temperature properties
A lubricant or process fluid composition having excellent low temperature properties comprises a capped estolide ester, a polyalphaolefin, a synthetic ester and/or polyalkylene glycol, and a pour point depressant. The combination of the three base oils plus the pour point depressant produces a synergistic composition that may have a pour point less than −15° C., preferably less than −35° C., while also having more than 50 percent by weight renewable carbons and being economical and effective in a wide variety of applications. |
| US08609594B2 |
Chlorine dioxide precursor and methods of using same
According to one aspect of the invention, a method of converting an oxy halide salt into a halide dioxide in a reaction zone under certain conditions is provided. More specifically, the method includes generating chlorine dioxide from a stable composition comprising an oxy halide salt by introducing said composition to a reducing agent and minimum temperature within the reaction zone. According to another aspect of the invention, a composition for a stable chlorine dioxide precursor comprising an oxy halide salt is provided. |
| US08609593B2 |
Extremely low resistance films and methods for modifying and creating same
Operational characteristics of an extremely low resistance (“ELR”) film comprised of an ELR material may be improved by depositing a modifying material onto appropriate surfaces of the ELR film to create a modified ELR film. In some implementations of the invention, the ELR film may be in the form of a “c-film.” In some implementations of the invention, the ELR film may be in the form of an “a-b film,” an “a-film” or a “b-film.” The modified ELR film has improved operational characteristics over the ELR film alone or without the modifying material. Such operational characteristics may include operating in an ELR state at increased temperatures, carrying additional electrical charge, operating with improved magnetic properties, operating with improved mechanic properties or other improved operational characteristics. In some implementations of the invention, the ELR material is a mixed-valence copper-oxide perovskite, such as, but not limited to YBCO. In some implementations of the invention, the modifying material is a conductive material that bonds easily to oxygen, such as, but not limited to, chromium. |
| US08609589B2 |
Fungicidal agent combinations
The invention relates to novel fungicidally active compound combinations of 2′-cyano-3,4-dichloroisothiazole-5-carboxanilide of the formula and active compounds listed in the disclosure. |
| US08609587B2 |
Synergistic herbicidal compositions containing propyzamide and aminopyralid
An herbicidal composition containing (a) propyzamide and (b) aminopyralid provides synergistic control of selected weeds in oilseed rape and in broadleaf, grass and perennial crops. |
| US08609586B2 |
Safening composition of 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylate herbicides and cloquintocet-mexyl for cereal crops
Herbicidal injury caused by 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylates in wheat and barley is reduced with the use of low rates of cloquintocet. |
| US08609585B2 |
Composition and method for controlling plant diseases
The present invention provides a composition for controlling plant diseases comprising, as active ingredients, a compound represented by formula (1) and ethaboxam. |
| US08609582B2 |
Thermosensitive recording medium
The present invention presents a thermosensitive recording medium having sufficient water resistance against water or moisture when the thermosensitive recording medium is used outdoors and also having a superior printing run-ability when printing at high speed (sticking resistance), color developing sensitivity, scratching resistance, plasticizer resistance and solvent resistance.The thermosensitive recording medium shows a superior water resistance and also shows a superior printing run-ability when printing at high speed (sticking resistance) etc, by installing a thermosensitive recording layer on a support and a protective layer on the thermosensitive recording layer, wherein the protective layer contains an acrylic resin with a glass transition temperature of higher than 50 degrees C. and lower than or equal to 95 degrees C. |
| US08609578B2 |
Exhaust gas purifying catalyst
An exhaust gas purifying catalyst is constituted by: noble metal particles (1); first compounds (2) which support the noble metal particles (1); second compounds (3) different in type from the first compounds (2); and oxides (4) which surround the noble metal particles (1), the first compounds (2) and the second compounds (3). A median diameter of the first compounds (2) and a median diameter of the second compounds (3) satisfy a relationship of a following inequality: median diameter of first compounds |
| US08609576B2 |
Catalysts containing tungstate for the synthesis of alkyl mercaptan and method for the production thereof
The invention relates to a catalyst containing alkali tungstate for the synthesis of alkylmercaptanes from alkanols and hydrogen sulphide, in addition to a method for the production of said catalyst, wherein the molar ratio of alkali to tungstan is <2:1. |
| US08609574B2 |
In situ olefin polymerization catalyst system
Embodiments in accordance with the present invention encompass methods of forming in situ olefin polymerization catalyst systems, catalysts encompassed by such systems and polymers made using such systems. For such in situ olefin polymerization catalyst systems, a hydrocarbyl magnesium halide is generally contacted with a halohydrocarbyl compound to form a halohydrocarbyl Grignard and such Grignard is generally contacted with a Group 10 metal compound to form an olefin polymerization catalyst which is contacted with one or more olefin monomers to form a polymer therefrom. |
| US08609573B2 |
Photocatalytic methods for preparation of electrocatalyst materials
The invention relates to methods of preparing metal particles on a support material, including platinum-containing nanoparticles on a carbon support. Such materials can be used as electrocatalysts, for example as improved electrocatalysts in proton exchange membrane fuel cells (PEM-FCs). |
| US08609572B2 |
Basic ionic liquids
Use of ionic liquids as solvents in base-catalysed chemical reactions wherein the ionic liquid is composed of at least one species of cation and at least one species of anion, characterized in that a cation of the ionic liquid comprises a positively charge moiety and a basic moiety, and further wherein such ionic liquids may be used as promoters or catalysts for the chemical reactions. |
| US08609568B2 |
Catalyst for oxidative dehydrogenation of propane to propylene
The catalyst for oxidative dehydrogenation of propane to propylene includes vanadium and aluminum incorporated into the framework of a mesoporous support, viz., MCM-41, to form V—Al-MCM-41, and nickel impregnated onto the walls of the mesoporous support. Nickel loading is preferably in the range of 5 to 15% by weight of the catalyst. A process for the production of propylene from propane includes steps of placing the catalyst in a fixed bed reactor, introducing a flow of feedstock in a propane:oxygen:nitrogen ratio of about 6:6:88 by volume, maintaining the reactor at atmospheric pressure and in a temperature range of about 400 to 550° C., collecting the product, and separating propylene from the product. The process achieves propane conversion between about 6 to 22%, and a selectivity for propylene between about 22 and 70%, depending upon percent nickel content and temperature of the reaction. |
| US08609567B2 |
OCP catalyst with improved steam tolerance
A catalyst is present for use in an olefin cracking process. The catalyst is a zeolite that has been loaded with an alkaline earth metal. The alkaline earth metal loaded catalyst has an increased steaming tolerance and increases the useful life of the catalyst during the cracking process and the regeneration cycle. |
| US08609562B2 |
Plate brick production method and plate brick
Disclosed is a method of producing a plate brick, which comprises: adding an organic binder to a refractory raw material mixture containing aluminum and/or an aluminum alloy; kneading them; forming the kneaded mixture into a shaped body; and burning the shaped body in a nitrogen gas atmosphere at a temperature of 1000 to 1400° C., wherein: when a temperature of a furnace atmosphere is 300° C. or more, the atmosphere is set to a nitrogen gas atmosphere; and when the temperature of the furnace atmosphere is 1000° C. or more, an oxygen gas concentration in the atmosphere is maintained at 100 volume ppm or less, and a sum of a carbon monoxide gas concentration and a carbon dioxide gas concentration is maintained at 1.0 volume % or less. This makes it possible to form a large amount of fine and uniform aluminum nitride in a plate brick to prevent microstructural degradation due to hydration caused by formation of aluminum carbide and suppress oxidation of a carbon bond so as to improve surface-roughening resistance. |
| US08609561B2 |
Metal colloid-colored glass ceramic and colorless glass convertible into same
A colorless transparent colloid-former-containing glass that is convertible into a colorless transparent glass ceramic or a metal colloid-colored glass ceramic via respective heat treatments contains a combination of one or more metal colloid formers and one or more redox partners. The metal colloid formers are preferably oxides containing Au, Ag, As, Bi, Nb, Cu, Fe, Pd, Pt, Sb and/or Sn. The redox partners are preferably oxides containing As, Ce, Fe, Mn, Sb, Sn and/or W, with the proviso that the redox partner must be different from the metal colloid former. The glass advantageously contains from 0.97 to 1.9 wt. % SnO2, 0.93 to 3.0 wt. % As2O3, or 1.59 to 6.0 wt. % of Sb2O3 as redox partner. |
| US08609560B2 |
Optical glass, preform for precision press molding, optical element, and method for manufacturing optical element
The present invention relates to an optical glass having a refractive index nd of 1.86 or higher and an Abbé number v(nu)d of 28 to 36; a preform for precision press molding and an optical element that are comprised of this glass; and a method for manufacturing the optical element. |
| US08609558B2 |
Tackifier composition
A tackifier composition includes a carrier solvent, a resin material, and an inorganic filler. The tackifier composition may be deposited onto at least a portion of a woven fiber structure and then dried to remove the carrier solvent. The dried woven fiber structure may then be formed into a preform. |
| US08609556B2 |
Thin film deposition apparatus with an expanding thermal plasma source and method for depositing a thin film using the same
Assembly and method for depositing a thin film including: providing an expanding thermal plasma plume, including at least one chemical component to be deposited; designating a first and a second deposition zone within the plasma plume, such that the first and second deposition zones have a mutually different relative content of the chemical component; providing a substrate, and transporting said substrate through the plasma plume along a substrate transport path having a substrate transport path direction; and providing a mask that is at least partly disposed in the plasma plume and that shields a portion of the substrate transport path from being deposited on, wherein said shielded portion of the substrate transport path extends in the direction of the substrate transport path and bridges at least the first deposition zone, while it starts or terminates in the second deposition zone. |
| US08609555B2 |
Increased stability of a complex material stack in a semiconductor device by providing fluorine enriched interfaces
When forming complex metallization systems, a sensitive material, such as a ULK material, may be deposited on a silicon-containing dielectric material, such as an etch stop material, with superior adhesion by performing a surface treatment on the basis of fluorine radicals. Due to the fluorine treatment, silicon-fluorine bonds are generated, which are then broken up upon interacting with the chemically active component during the further deposition process. Consequently, the subsequent material layer is chemically bonded to the underlying material, thereby imparting superior stability to the interface, which in turn may result in superior robustness and reliability of the metallization system upon performing reflowing processes and operating complex packaged semiconductor devices. |
| US08609550B2 |
Methods for manufacturing integrated circuit devices having features with reduced edge curvature
A structure, such as an integrated circuit device, is described that includes a line of material with critical dimensions which vary within a distribution substantially less than that of a mask element, such as a patterned resist element, used in etching the line. Techniques are described for processing a line of crystalline phase material which has already been etched using the mask element, in a manner which straightens an etched sidewall surface of the line. The straightened sidewall surface does not carry the sidewall surface variations introduced by photolithographic processes, or other patterning processes, involved in forming the mask element and etching the line. |
| US08609546B2 |
Pulsed bias plasma process to control microloading
A method for etching a conductive layer through a mask with wider and narrower features is provided. A steady state etch gas is flowed. A steady state RF power is provided to form a plasma from the etch gas. A pulsed bias voltage is provided during the steady state etch gas flow, wherein the pulsed bias voltage has a frequency between 1 to 10,000 Hz. Wider and narrower features are etched into the conductive layer using the plasma formed from the etch gas. |
| US08609542B2 |
Profiling solid state samples
Methods may operate to position a sample within a processing chamber and operate on a surface of the sample. Further activities may include creating a layer of reactive material in proximity with the surface, and exciting a portion of the layer of reactive material in proximity with the surface to form chemical radicals. Additional activities may include removing a portion of the material in proximity to the excited portion of the surface to a predetermined level, and continuing the creating, exciting and removing actions until at least one of a plurality of stop criteria occurs. |
| US08609541B2 |
Polishing slurry for metal films and polishing method
Provided are a polishing slurry for metal films and a polishing method which restrain the generation of erosion and seams, and makes the flatness of a surface polished therewith or thereby high. The slurry and the method are a polishing slurry, for metal films, comprising abrasive grains, a methacrylic acid based polymer and water, and a polishing method using the slurry, respectively. |
| US08609540B2 |
Reliable packaging and interconnect structures
Methods and apparatus for forming a semiconductor device are provided which may include any number of features. One feature is a method of forming an interconnect structure that results in the interconnect structure having a top surface and portions of the side walls of the interconnect structure covered in a dissimilar material. In some embodiments, the dissimilar material can be a conductive material or a nano-alloy. The interconnect structure can be formed by removing a portion of the interconnect structure, and covering the interconnect structure with the dissimilar material. The interconnect structure can comprise a damascene structure, such as a single or dual damascene structure, or alternatively, can comprise a silicon-through via (TSV) structure. |
| US08609539B2 |
Embedded semiconductor device substrate and production method thereof
An embedded semiconductor device substrate having a semiconductor device integrated therein is formed by disposing a semiconductor device in an opening provided on an insulating resin, and sandwiching the semiconductor device and the insulating resin with a front surface wiring layer and a rear surface wiring layer and performing heat pressing. Connection between bumps of the semiconductor device and the front surface wiring layer is made with a connection wiring pattern. The connection wiring pattern is formed by patterning a resist film by direct exposure thereof with a light beam, and then performing etching. Thereby, it becomes possible to absorb a mounting error of a semiconductor device to a printed wiring board and a positional error of electrodes between semiconductor devices accompanying the tendency of reduction of the pitch of a semiconductor device, and to perform electric connection with a wiring pattern securely. |
| US08609532B2 |
Magnetically sintered conductive via
The present disclosure relates to the field of fabricating microelectronic packages, wherein microelectronic components of the microelectronic packages may have sintered conductive vias comprising sintered metal and magnetic particles. |
| US08609528B1 |
High-density patterning
Methods for patterning high-density features are described herein. Embodiments of the present invention provide a method comprising patterning a first subset of a pattern, the first subset configured to form a plurality of lines over the substrate, and patterning a second subset of the pattern, the second subset configured to form a plurality of islands over the substrate, wherein said patterning the first subset and said patterning the second subset comprise at least two separate patterning operations. |
| US08609524B2 |
Method for making semiconductor device comprising replacement gate electrode structures with an enhanced diffusion barrier
In sophisticated semiconductor devices, the integrity of the device level may be enhanced after applying a replacement gate approach by providing an additional diffusion barrier layer, such as a silicon nitride layer, thereby obtaining a similar degree of diffusion blocking capabilities as in semiconductor devices without performing a replacement gate approach. |
| US08609523B2 |
Method of making a memory array with surrounding gate access transistors and capacitors with global staggered local bit lines
A memory array with staggered local data/bit lines extending generally in a first direction formed in an upper surface of a substrate and memory cell access transistors extending generally upward and aligned generally atop a corresponding local data/bit line. Selected columns of the memory cell access transistors are sacrificed to define local data/bit access transistors which are interconnected with overlying low resistance global data/bit lines. The global data/bit lines provide selectable low resistance paths between memory cells and sense amplifiers. The sacrificed memory cell access transistors and staggered local data/bit lines provide increased footprints for sense amplifiers to facilitate increased circuit integration. |
| US08609522B2 |
Process for producing a conducting electrode
A process for producing a conducting electrode on a substrate, including: depositing a layer made of a dielectric; depositing a protective layer made of the nitride of a metal on the dielectric layer; depositing a functionalization layer made of a material including a chemical species, such that the free enthalpy of formation of the nitride of the species is less, in absolute value, than the free enthalpy of formation of the nitride of the metal of the protective layer over the temperature range between 0° C. and 1200° C.; and annealing the assembly including the protective layer and the funtionalization layer so that the species diffuse from the functionalization layer into the protective layer and the nitrogen atoms migrate from the protective layer into the functionalization layer. |
| US08609518B2 |
Re-growing source/drain regions from un-relaxed silicon layer
A method of forming an n-type metal-oxide-semiconductor (NMOS) field-effect transistor (FET) includes forming a silicon germanium layer, and forming a silicon layer over the silicon germanium layer. A gate stack is formed over the silicon layer. The silicon layer is recessed to form a recess adjacent the gate stack. A silicon-containing semiconductor region is epitaxially grown in the recess to form a source/drain stressor, wherein the silicon-containing semiconductor region forms a source/drain region the NMOS FET. |
| US08609517B2 |
MOCVD for growing III-V compound semiconductors on silicon substrates
A device includes providing a silicon substrate; annealing the silicon substrate at a first temperature higher than about 900° C.; and lowering a temperature of the silicon substrate from the first temperature to a second temperature. A temperature lowering rate during the step of lowering the temperature is greater than about 1° C./second. A III-V compound semiconductor region is epitaxially grown on a surface of the silicon substrate using metal organic chemical vapor deposition (MOCVD). |
| US08609515B2 |
Dicing die bonding film, semiconductor wafer, and semiconductor device
A dicing die bonding film including a bonding layer; and a pressure-sensitive adhesive layer adjoining the bonding layer, the pressure-sensitive adhesive layer having a storage modulus of about 400 to about 600 kPa at 25° C. and a peel strength of about 200 to about 350 mN/25 mm with respect to the bonding layer as measured according to KS-A-01107 standard. |
| US08609511B2 |
Semiconductor device manufacturing method, semiconductor device, and camera module
According to one embodiment, an insulation film is formed over the surface, backside, and sides of a first substrate. Next, the insulation film formed over the surface of the first substrate is removed. Then, a joining layer is formed over the surface of the first substrate, from which the insulation film has been removed. Subsequently, the first substrate is bonded to a second substrate via a joining layer. |
| US08609507B2 |
Semiconductor device and method of manufacturing the same
A semiconductor device includes gates formed over a semiconductor substrate that are spaced apart from one another and each have a stack structure of a tunnel insulation layer, a floating gate, a dielectric layer, a first conductive layer, and a metal silicide layer, a first insulation layer formed along the sidewalls of the gates and a surface of the semiconductor substrate between the gates and configured to have a height lower than the top of the metal silicide layer; and a second insulation layer formed along surfaces of the first insulation layer and surfaces of the metal silicide layer and configured to cover an upper portion of a space between the gates, wherein an air gap is formed between the gates. |
| US08609505B2 |
Method of forming MIM capacitor structure in FEOL
A capacitor structure includes a semiconductor substrate; a first capacitor plate positioned on the semiconductor substrate, the first capacitor plate including a polysilicon structure having a surrounding spacer; a silicide layer formed in a first portion of an upper surface of the first capacitor plate; a capacitor dielectric layer formed over a second portion of the upper surface of the first capacitor plate and extending laterally beyond the spacer to contact the semiconductor substrate; a contact in an interlayer dielectric (ILD), the contact contacting the silicide layer and a first metal layer over the ILD; and a second capacitor plate over the capacitor dielectric layer, wherein a metal-insulator-metal (MIM) capacitor is formed by the first capacitor plate, the capacitor dielectric layer and the second capacitor plate and a metal-insulator-semiconductor (MIS) capacitor is formed by the second capacitor plate, the capacitor dielectric layer and the semiconductor substrate. |
| US08609502B1 |
Method of manufacturing semiconductor device including insulated gate bipolar transistor and diode
In a method of manufacturing a semiconductor device, a semiconductor substrate of a first conductivity type having first and second surfaces is prepared. Second conductivity type impurities for forming a collector layer are implanted to the second surface using a mask that has an opening at a portion where the collector layer will be formed. An oxide layer is formed by enhanced-oxidizing the collector layer. First conductivity type impurities for forming a first conductivity type layer are implanted to the second surface using the oxide layer as a mask. A support base is attached to the second surface and a thickness of the semiconductor substrate is reduced from the first surface. An element part including a base region, an emitter region, a plurality of trenches, a gate insulating layer, a gate electrode, and a first electrode is formed on the first surface of the semiconductor substrate. |
| US08609498B2 |
Transistor with embedded Si/Ge material having reduced offset and superior uniformity
In sophisticated semiconductor devices, a strain-inducing embedded semiconductor alloy may be provided on the basis of a crystallographically anisotropic etch process and a self-limiting deposition process, wherein transistors which may not require an embedded strain-inducing semiconductor alloy may remain non-masked, thereby providing superior uniformity with respect to overall transistor configuration. Consequently, superior strain conditions may be achieved in one type of transistor, while generally reduced variations in transistor characteristics may be obtained for any type of transistors. |
| US08609496B2 |
Method of fabricating semiconductor device comprising a dummy well
Provided are a semiconductor device and a method of fabricating the semiconductor device. The semiconductor device can include first transistors that include a first gate insulating layer having a first thickness and second transistors include a second gate insulating layer having a second thickness less than the first thickness. At least one of the transistors formed on the first or second gate insulating layers is directly over a dummy well. |
| US08609495B2 |
Hybrid gate process for fabricating finfet device
Provided is a method of fabricating a semiconductor device that includes forming first and second fins over first and second regions of a substrate, forming first and second gate structures over the first and second fins, the first and second gate structures including first and second poly gates, forming an inter-level dielectric (ILD) over the substrate, performing a chemical mechanical polishing on the ILD to expose the first and second poly gates, forming a mask to protect the first poly gate of the first gate structure, removing the second poly gate thereby forming a first trench, removing the mask, partially removing the first poly gate thereby forming a second trench, forming a work function metal layer partially filling the first and second trenches, forming a fill metal layer filling a remainder of the first and second trenches, and removing the metal layers outside the first and second trenches. |
| US08609491B2 |
Method for fabricating semiconductor device with buried bit lines
A method for fabricating a semiconductor device includes etching a substrate to form trenches that separate active regions, forming an insulation layer having an opening to open a portion of a sidewall of each active region, forming a silicon layer pattern to gap-fill a portion of each trench and cover the opening in the insulation layer, forming a metal layer over the silicon layer pattern, and forming a metal silicide layer as buried bit lines, where the metal silicide layer is formed when the metal layer reacts with the silicon layer pattern. |
| US08609486B1 |
Methods for fabricating deep trench capacitors
Integrated circuits with transistors and decoupling capacitor structures are provided. A decoupling capacitor structure may include multiple deep trench structures formed in a semiconductor substrate. The deep trench structures may each be lined with high-κ dielectric material. A conductive metal layer for use in controlling threshold voltages associated with n-channel or p-channel devices may be formed over the high-κ dielectric liner. Conductive material such as aluminum may be used to fill the remaining trench cavity. The high-κ dielectric liner may be simultaneously deposited into the deep trench structures and gate regions of the transistors. In one suitable arrangement, the deep trench structures and transistor metal gates for at least a selected type of transistors may be formed in parallel. In another suitable arrangement, the deep trench structures and the transistor metal gates may be formed in separate steps. |
| US08609483B2 |
Method of building compensated isolated P-well devices
Electrical device structures constructed in an isolated p-well that is wholly contained within a core n-well. Methods of forming electrical devices within an isolated p-well that is wholly contained within a core n-well using a baseline CMOS process flow. |
| US08609478B2 |
Method for manufacturing semiconductor device
It is an object to provide a highly reliable semiconductor device which includes a thin film transistor having stable electric characteristics. It is another object to manufacture a highly reliable semiconductor device at lower cost with high productivity. In a method for manufacturing a semiconductor device which includes a thin film transistor where a semiconductor layer including a channel formation region using an oxide semiconductor layer, a source region, and a drain region are formed using an oxide semiconductor layer, heat treatment for reducing impurities such as moisture (heat treatment for dehydration or dehydrogenation) is performed so as to improve the purity of the oxide semiconductor layer. |
| US08609477B2 |
Manufacturing method for array substrate with fringe field switching type thin film transistor liquid crystal display
A manufacturing method for an array substrate with a fringe field switching (FFS) type thin film transistor (TFT) liquid crystal display (LCD) includes the following steps. A pattern of a gate line (1), a gate electrode, a common electrode (6) and a common electrode line (5) is formed by patterning a first transparent conductive film and a first metal film formed successively on a transparent substrate. Contact holes of the gate line in the pad area and a semiconductor pattern are formed through a patterning process after a gate insulator film, and a semiconductor film and a doped semiconductor film are formed successively. A second metal film is deposited and patterned. A second transparent conductive film is deposited and a lift-off process is performed. And then, a pattern of a source electrode, a drain electrode, a TFT channel and a pixel electrode (4) is formed by etching the exposed second metal film and the doped semiconductor film. |
| US08609474B2 |
Method of manufacturing semiconductor device
Disclosed are a semiconductor device and a method of manufacturing the same. In the semiconductor device according to an exemplary embodiment of the present disclosure, at the time of forming a source electrode, a drain electrode, a field plate electrode, and a gate electrode on a substrate having a heterojunction structure such as AlGaN/GaN, the field plate electrode made of the same metal as the gate electrode is formed on the side surface of a second support part positioned below a head part of the gate electrode so as to prevent the gate electrode from collapsing and improve high-frequency and high-voltage characteristic of the semiconductor device. |
| US08609471B2 |
Packaging an integrated circuit die using compression molding
A structure (46) for holding an integrated circuit (IC) die (50) during packing includes a flexible structurally reinforced silicone adhesive film (22) and a mold frame (44). The mold frame (44) adheres to an adhesive side (38) of the film (22). A method (20) of packaging the IC die (50) includes placing the IC die (50) on the adhesive film (22) with its active surface (52) and bond pads (54) in contact with an adhesive side (38) of the film (22). A molding compound (58) is dispensed over the IC die, and the IC die (50) is encapsulated using compression molding to form a compression molded encapsulant layer (70). IC die (50) is subsequently released from the film (22) as a panel (72) of IC dies (50). |
| US08609458B2 |
Method for producing graphene oxide with tunable gap
A method of fabricating a graphene oxide material in which oxidation is confined within the graphene layer and that possesses a desired band gap is provided. The method allows specific band gap values to be developed. Additionally, the use of masks is consistent with the method, so intricate configurations can be achieved. The resulting graphene oxide material is thus completely customizable and can be adapted to a plethora of useful engineering applications. |
| US08609451B2 |
Insitu epitaxial deposition of front and back junctions in single crystal silicon solar cells
Fabrication of a single crystal silicon solar cell with an insitu epitaxially deposited very highly doped p-type silicon back surface field obviates the need for the conventional aluminum screen printing step, thus enabling a thinner silicon solar cell because of no aluminum induced bow in the cell. Furthermore, fabrication of a single crystal silicon solar cell with insitu epitaxial p-n junction formation and very highly doped n-type silicon front surface field completely avoids the conventional dopant diffusion step and one screen printing step, thus enabling a cheaper manufacturing process. |
| US08609448B2 |
Omnidirectional reflector
A system and method for manufacturing an LED is provided. A preferred embodiment includes a substrate with a distributed Bragg reflector formed over the substrate. A photonic crystal layer is formed over the distributed Bragg reflector to collimate the light that impinges upon the distributed Bragg reflector, thereby increasing the efficiency of the distributed Bragg reflector. A first contact layer, an active layer, and a second contact layer are preferably either formed over the photonic crystal layer or alternatively attached to the photonic crystal layer. |
| US08609444B2 |
Manufacturing method of mounting part of semiconductor light emitting element, manufacturing method of light emitting device, and semiconductor light emitting element
A manufacturing method of a mounting part of a semiconductor light emitting element comprising: preparing a semiconductor light emitting element including an electrode which has a surface, and a board which has a surface; forming a plurality of bump material bodies on at least one of the surface of the electrode and the surface of the board by shaping bump material into islands, wherein the bump material is paste in which metal particles are dispersed, a top surface and a bottom surface of the bump material bodies have different areas, and the top surface is practically flat; solidifying the bump material bodies by thermally processing the bump material bodies; and fixing the semiconductor light emitting element and the board through the bumps. |
| US08609443B2 |
Semiconductor device manufacturing method
A semiconductor device manufacturing apparatus is provided with a drawing pattern printing part having a print head which injects a conductive solvent, an insulative solvent and an interface treatment solution. The print head is formed in such a way that desired circuit drawing pattern can be printed on a wafer based on information on the drawing pattern from a wafer testing part, information on the wafer from a storage part and coordinate information from a chip coordinate recognition part. In a semiconductor device manufacturing method according to the present invention, a semiconductor device is manufactured by using the semiconductor device manufacturing apparatus in such a manner that desired circuits are formed through printing process. In the semiconductor device, pad electrodes and so on are formed in such a way that trimming process can be conducted by printing circuit drawing patterns. |
| US08609442B2 |
Vapor deposition method, vapor deposition device and organic EL display device
A coating film (90) is formed by causing vapor deposition particles (91) discharged from a vapor deposition source opening (61) of a vapor deposition source (60) to pass through a space between a plurality of control plates (81) of a control plate unit (80) and a mask opening (71) of a vapor deposition mask in this order and adhere to a substrate, while the substrate (10) is moved relative to the vapor deposition mask (70) in a state in which the substrate (10) and the vapor deposition mask (70) are spaced apart at a fixed interval. A difference in the amount of thermal expansion between the vapor deposition source and the control plate unit is detected and corrected. It is thereby possible to form, at a desired position on a large-sized substrate, the coating film in which edge blur and variations in the edge blur are suppressed. |
| US08609440B2 |
Semiconductor device and method of manufacturing same
A semiconductor device includes a substrate and a ferroelectric capacitor including a lower electrode, a ferroelectric film, and an upper electrode. The upper electrode includes a first layer formed of an oxide whose stoichiometric composition is expressed as AOx1 and whose actual composition is expressed as AOx2; a second layer formed on the first layer and formed of an oxide whose stoichiometric composition is expressed as BOy1 and whose actual composition is expressed as BOy2; and a metal layer formed on the second layer. The second layer is higher in ratio of oxidation than the first layer. The composition parameters x1, x2, y1, and y2 satisfy y2/y1>x2/x1, and the second layer includes an interface layer of the stoichiometric composition formed at an interface with the metal layer. The interface layer is higher in ratio of oxidation than the rest of the second layer. |
| US08609438B2 |
Protein-immobilized electrode and method of manufacturing the same, and functional element and method of manufacturing the same
In one example embodiment, a protein-immobilized electrode is stably used for long time. In one example embodiment, a method of manufacturing the protein-immobilized electrode includes immobilizing cytochrome c552 having high stability to a chemically-stable gold electrode while maintaining electron transfer capability of the cytochrome c552. In one example embodiment, a self-assembled monolayer is formed on a gold electrode by using hydrophobic thiol and hydrophilic thiol. By dipping the gold electrode on which the self-assembled monolayer is formed in a cytochrome c552 solution, a protein-immobilized electrode in which a cytochrome c552 is immobilized to the gold electrode with the self-assembled monolayer in between is produced. |
| US08609437B2 |
Biomarkers for the diagnosis and treatment of pancreatic cancer
Compositions and methods for use in methods and kits for the detection of an increased risk of pancreatic cancer are provided. Cyst fluid samples isolated from patients that are positive for at least three of the following markers, mucin 1, mucin 2, mucin 5AC, mucin 5B, mucin 6, CEA CAM 1, CEACAM 5, CEACAM 6, CEACAM 7, CEACAM 8, S100-A6, S100-A8, S100-A9 and S100-A11 indicate that such patients are at greater risk for the development of pancreatic cancer when compared to cyst fluid samples isolated from patients lacking these markers. |
| US08609436B2 |
Method
The invention provides a method of detecting the presence of anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants, derivatives or fragments thereof and detecting the binding or absence of binding of antibodies to said recombinant MHC molecules. This method allows the detection and/or identification of one or more specific MHC particularly HLA allele antibodies. |
| US08609434B2 |
Bio-disc reading apparatus and assay method using same
Provided is a bio-disc reading apparatus for reading information including product authentication of a bio-disc and assay site of a bio-disc, and an assay method using same. |
| US08609429B2 |
Methods for identifying high fouling hydrocarbon and for mitigating fouling of process equipment
Methods for determining the fouling propensity of a hydrocarbon stream and for reducing fouling are provided. In one method, the fouling propensity of a hydrocarbon stream is determined by obtaining a parameter value indicative of the fouling propensity at no less than two different temperatures, and an activation energy of fouling by the hydrocarbon stream is derived therefrom. In another method, the thus obtained parameter value at no less than two different temperatures and the activation energy are used to select proper heating fluids and operating temperature and to determine whether to add an antifoulant to the hydrocarbon stream to reduce fouling at a given temperature. |
| US08609428B2 |
Colorimetric assay for pyrethroid insecticides on solid items
The invention relates to an assay to test for pyrethroids in a sample. The assay is particularly useful for testing material treated with pyrethroids, such as bed netting and the like. |
| US08609421B2 |
Single-molecule real-time analysis of protein synthesis
The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of analytical reactions in which protein synthesis is occurring. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to either enhance, inhibit, or otherwise affect such reactions including, but not limited to, affecting the reaction rate, processivity, fidelity, duration, and the like. |
| US08609416B2 |
Methods and compositions comprising heat shock proteins
Compositions, and uses thereof, which are beneficial for eukaryotic cells in culture, and methods for their use in promoting cell growth, viability and recombinant protein expression. The methods disclosed in the present application are useful, for example, for improving cell viability and in accelerating the rate of cell growth of cells grown in culture. In one aspect, the supplements of the invention are useful for improving or enhancing the yield of the recombinant proteins from the cell cultures. |
| US08609413B2 |
Neurons, astrocytes and oligodendrocytes differentiated from a mammalian pluripotent or neural stem cells exposed to a pyridine deriviative
A method of preparing neural precursor cells by exposing pluripotent stem cells or neural stem cells to a differentiation agent. The agent is a pyridine analog, which in preferred embodiments is a phenylethynyl-substituted or phenylazo-substituted pyridine. In other embodiments, a method of enhancing neural precursor cell survival is provided in which the survival is enhanced by exposure to the pyridine analog. In further embodiments, a method of preparing neuronal cells is provided in which pluripotent or neural stem cells exposed to the pyridine analog are then incubated without the pyridine analog, resulting in differentiation into neurons, astrocytes and oligodendrocytes. These methods may be used in toxicological screens, e.g., to evaluate the neurotoxicity of a test compound. |
| US08609412B2 |
Mapc generation of lung tissue
The present invention relates to methods of improving function in lung tissue by administering a population of multipotent adult progenitor cells (“MAPCs”) or differentiated progeny thereof. |
| US08609411B2 |
Ex vivo expansion of human hematopoietic stem cells
Methods and kits for expanding the number of hematopoietic stem cells are provided. The methods comprise incubating cells in medium comprising isolated IGFBP-2 and an angiopoietin-like protein (Angptl). Expanded HSCs are provided as well as culture media and kits for the expansion of human HSCs in a defined medium. Methods of administering expanded human HSCs to and individual are provided as well as methods of treating an individual by administering certain growth factors and cytokines. |
| US08609410B2 |
Method for activation treatment of antigen-presenting cell
Activated antigen-presenting cells that can induce immunocytes including disease antigen-specific CD8+ CTLs and/or γδ T cells efficiently in vivo and/or in vitro, a medical composition comprising the activated antigen-presenting cells, a treatment and prevention method using the activated antigen-presenting cells, and an induction method of immunocytes including disease antigen-specific CTLs and/or γδ T cells induced using the activated antigen-presenting cell, immunocytes induced by the above-noted method, a medical composition comprising the immunocytes, and a treatment and prevention method using the immunocytes are provided. By co-pulsing antigen-presenting cells with bisphosphonate in addition to the pulse with a disease antigen, the ratio of disease antigen-specific CD8+ CTLs and/or γδ T cells and the number of the disease antigen-specific CD8+ CTLs and the γδ T cells can be increased, compared with the case where the co-pulse with bisphosphonate is not carried out. |
| US08609409B2 |
Methods and compositions for cell culture platform
The present invention provides a synthetic cell culture platform, comprising: a two dimensional and/or three dimensional surface comprising peptides conjugated to said surface and methods of using the platform for increasing cell adhesion, stable attachment and/or proliferation of cells grown on the platform and for promoting differentiation of neural stem cells into neurons. |
| US08609404B2 |
Vaccines containing canine parvovirus genetic variants
Canine parvovirus vaccines and diagnostics and methods for their use are provided. The vaccines are effective against emerging canine parvovirus variants. |
| US08609403B2 |
Polynucleotide derived from novel hepatitis C virus strain and use thereof
A polynucleotide encoding the amino acid shown in SEQ ID NO:2 or SEQ ID NO: 5, or encoding an amino acid sequence having not less than 98% identity thereto; preferably a polynucleotide comprising replacement of the amino acid corresponding to glutamic acid at position 1202 of SEQ ID NO:2 (position 177 of SEQ ID NO:5) with glycine, replacement of the amino acid corresponding to glutamic acid at position 1056 (position 31 of SEQ ID NO:5) with valine, and replacement of the amino acid corresponding to alanine at position 2199 (position 1174 of SEQ ID NO:5) with threonine. |
| US08609401B2 |
Detection of proteases secreted from a pathogenic microorganisms
A diagnostic test kit for detecting the presence or absence of a protease (e.g., aminopeptidase) within a test sample is provided. The test kit comprises a substrate that is capable of being cleaved in the presence of the protease to release a compound. The kit also comprises a lateral flow device that comprises a chromatographic medium. The chromatographic medium defines a detection zone within which is contained a first reagent (e.g., diazonium ion) that is capable of reacting with the compound to form a second reagent (e.g., aromatic azo compound). The second reagent exhibits a color that is different than the color of the first reagent. The lateral flow device also includes an absorbent material located adjacent to the chromatographic medium, the absorbent material receiving the test sample after flowing through the chromatographic medium. |
| US08609400B2 |
Apparatus and method for maintaining and/or restoring viability of organs
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. |
| US08609399B2 |
Reducing insoluble deposit formation in ethanol production
The present inventors have surprisingly discovered that phytic acid tenaciously precipitates with soluble metals in food or fuel ethanol-processing fluid, producing insoluble organometallic salt deposit or scale on the processing equipment that must be removed in order to facilitate further ethanol processing. The present invention relates to converting phytic acid salts or phytates to inorganic phosphates to improve metal solubility and reduce deposition within processing equipment. |
| US08609398B1 |
Selective biodegradation of free fatty acids in fat-containing waste
A process of selectively degrading fatty acids in fat-containing waste materials without significant degradation of triglycerides, thereby converting otherwise economically burdensome waste materials into valuable products, involves contacting a fat-containing waste comprising triglycerides and fatty acids with a bacterial culture comprising Pseudomonas bacteria capable of degrading fatty acids into water and carbon dioxide, and wherein the bacterial culture is substantially free of microorganisms capable of producing extra-cellular lipase in an amount that would cause significant degradation of the triglycerides. |
| US08609395B2 |
Agonist and antagonist peptides of carcinoembryonic antigen (CEA)
The invention provides a polypeptide comprising an agonist of a MHC Class I binding native sequence having amino acid substitution(s) and enhanced immunogenicity compared to the native sequence. The invention provides DNA encoding the polypeptide, as well as vectors and cells comprising the DNA and methods comprising the administration of the polypeptide. |
| US08609394B2 |
Biotechnological production of chondroitin
Chondroitin is produced by culturing a recombinant microorganism which is obtained by inactivation of a gene encoding an enzyme responsible for addition of fructose residues to the linear chondroitin polysaccharide in a microorganism producing a fructosylated derivative of chondroitin. |
| US08609393B2 |
Fluorescent proteins and genes encoding them
Fluorescent proteins comprising the following internal amino acid sequence (SEQ ID NO: 47) Gly Tyr Xaa Xaa Xaa Gln Tyr Leu Pro Xaa Pro 1 5 10 wherein Xaa in position 3 is Ala or Gly, Xaa in position 4 is Phe, His or Tyr, Xaa in position 5 is His, Tyr or Asn, or Xaa in position 10 is Phe or Tyr are disclosed. Such proteins are e.g. isolated or recombinant fluorescent proteins from a Cephalochordata, such as Branchiostoma floridae or Branchiostoma lanceolatum, or isolated mutants or recombinant proteins that have at least 80% amino acid sequence identity with the fluorescent proteins. Isolated and purified structural genes encoding such fluorescent proteins are also disclosed. |
| US08609389B2 |
Milk-clotting protease derived from a microorganism
The present invention provides an improved type protease which comprises an amino acid sequence that is at least 75% identical to SEQ ID NO:3, said improved type protease has at least one mutation selected from the group consisting of: (A) replacement of glutamine corresponding to glutamine at position 265 in SEQ ID NO: 3 with an acidic amino acid; and (B) replacement of glutamine at position 266 in SEQ ID NO: 3 with an acidic amino acid, and wherein said improved type protease has milk-clotting activity. |
| US08609388B2 |
Modified family 5 cellulases and uses thereof
The present invention relates to a modified Family 5 cellulase comprising a substitution of an amino acid at position 363 with a non-native alanine, serine or threonine, the position determined from alignment of the modified Family 5 cellulase with amino acids 71-397 of a Trichoderma reesei Cel5A amino acid sequence as set forth in SEQ ID NO:1 and enzyme mixtures comprising same. Additionally provided is a genetic construct comprising a nucleic acid sequence encoding the modified Family 5 cellulase and a genetically modified microbe comprising the genetic construct. The invention also provides a process for producing the modified Family 5 cellulase. |
| US08609379B2 |
Process for the production of alcohols from biomass
Alcohols useful as fuel compositions are produced from biomass by pretreating the biomass prior to hydrolysis and fermentation. In the pretreatment, the biomass is contacted with an aqueous solution containing a dilute acid with concentration of up to 10 wt % producing a predigested stream containing an aqueous liquor that contains at least a portion of hemicelluloses and a residual biomass that contains celluloses and lignin; separating at least a portion of the aqueous liquor from the residual biomass providing an aqueous liquor stream and a pre-digested biomass stream; then contacting the pre-digested biomass stream with a cooking liquor containing at least one alkali selected from the group consisting of sodium hydroxide, sodium carbonate, sodium sulfide, potassium hydroxide, potassium carbonate, ammonium hydroxide, and mixtures thereof and water. A process that allows for higher recovery of carbohydrates and thereby increased yields is provided. |
| US08609375B2 |
Method for detecting viable cells in a sample by using a virus
A method for detecting viable cells such as bacterial cells, within a sample, said method comprising (i) incubating said sample with a virus which is able to infect said cells under conditions which allow said virus to infect and replicate within any such cells which are viable; and (ii) detecting any nucleic acid obtained by replication of the virus in said cell. |
| US08609373B2 |
Fusion protein mixture for inducing human pluripotent stem cell and preparation method there of
The invention provides the protein mixture including the fusion proteins of C-myc, SOX2, KLF4, OCT-4, wherein each protein comprises a protein transduction domain (PTD) and a small ubiquitin-like modifier (SUMO) fused with the said protein. The invention further provides the preparation method of the protein mixture and its use for inducing human pluripotent stem cell. |
| US08609369B2 |
Yarrowia peroxisomal 2,4-dienoyl-CoA reductase promoter regions for gene expression in yeast
Promoter regions associated with the Yarrowia lipolytica peroxisomal 2,4-dienoyl-CoA reductase (SPS19) gene are disclosed and have been found to be particularly effective for the expression of heterologous genes in yeast. These promoter regions will be useful for driving high-level expression of genes involved in the production of omega-3 and omega-6 fatty acids. |
| US08609368B2 |
Process for purifying vancomycin wet body
Provided is a process for purifying a vancomycin wet body, comprising: dissolving a wet body obtained from a microorganism-fermented solution containing vancomycin into a water soluble solvent to a concentration of about 1 to 40 g/L and carrying out reverse osmosis filtration; and carrying out lyophilization of the filtered vancomycin. The process for purifying a vancomycin wet body provides high-purity vancomycin, while avoiding degradation of stability during a drying step. |
| US08609364B2 |
Methods for antimicrobial resistance determination
The present invention relates to methods and systems for determining the antibiotic-resistance status of microorganisms. The invention further provides methods for determining the antibiotic-resistance status of microorganisms in situ within a single system. |
| US08609361B2 |
Real time electrophysiological testing of agents of interest for treatment of amyloid-type diseases
This invention corresponds to an in vitro method that employs an electrophysiology technique; in particular, an embodiment of the patch-clamp technique in its perforated type, which will allow us evaluating the neurotoxic capacity of protein structures associated to the generation of neurodegenerative diseases. It addition, it allows evaluating potential pharmacologic capacities of candidate molecules (drugs) in order to prevent, treat, or cure the said diseases. The invention involves the use of peptides that cause neurodegenerative diseases in order to form a spontaneous perforated recording that only occurs with peptides in the patch clamp glass pipette. |
| US08609357B2 |
Methods for detecting LP-PLA2 activity and inhibition of LP-PLA2 activity
This invention relates to methods for determining the activity of Lp-PLA2 in at least one sample from an animal. The invention also relates to methods for determining the inhibition of Lp-PLA2 activity in samples from animals that are administered an Lp-PLA2 inhibitor. |
| US08609355B2 |
Assays for the detection of microbes
Methods, devices, and kits are provided herein for the accurate and rapid detection of disease causing microbes in a sample by the detection of microbial components of which correlate to the presence of the microbe. Kits include a first binding agent operatively coupled to an immobilized support; and a second binding agent operatively coupled to one or more pH indicating moieties wherein the first and second binding agents bind with sufficient specificity to the microbial component to permit detection of that component which correlates to the presence of the microbe in the sample. |
| US08609354B2 |
Method for selecting patients for treatment with an EGFR inhibitor
The present invention relates to cancer diagnostics and therapies and to the detection of alterations in cancer cells that are diagnostic, prognostic or predictive. In particular, the present invention provides a method for detecting and analyzing whether a patient suffering from a cancer is responsive to the treatment with an EGFR inhibitor. In the method, a tissue section from a cancer sample is subjected to assays based on immunohistochemistry and enzymatic metallography. |
| US08609346B2 |
Method for diagnosing alzheimer's disease using serum glycoprotein as biomarker
It is an object of the present invention to detect a change in the metabolism of a glycoprotein having an α2,6-sialyl residue, which is contained in blood, so as to provide an agent and a method for diagnosing sporadic Alzheimer's disease. The present invention provides an agent for diagnosing Alzheimer's disease, which comprises lectin used for detecting an α2,6-sialyl residue-containing glycoprotein. |
| US08609345B2 |
Diagnosis of diseases and conditions by analysis of histopathologically processed biological samples using liquid tissue preparations
The invention provides methods for diagnosing diseases such as cancer and other conditions using biological samples. Liquid Tissue samples prepared from histopathologically prepared tissue obtained from a subject surprisingly can be used to identify and, optionally, to quantify analytes that are diagnostic of the presence of a disease, condition or syndrome in the subject. |
| US08609342B2 |
Reporter gene assay method
The invention provides a reporter gene assay method by which the sex hormone-like activity inherent in a test substance can be accurately assayed excluding the effects caused by a decrease in cell activity (protein expressing capacity). The assay method is a reporter gene assay method using luciferase-expressing cells which comprises further transferring a GFP gene into the luciferase-expressing cells, measuring the luciferase expression level and GFP expression level, and making a judgment about the thus-measured luciferase expression level using the decrease in GFP expression level as an indication of the decrease in cell activity. |
| US08609340B2 |
Control nucleic acids for multiple parameters
Methods are provided for the amplification of at least a first and a second target nucleic acid that may be present in at least one fluid sample using an internal control nucleic acid for qualitative and/or quantitative purposes. |
| US08609338B2 |
Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms
The invention provides tandem single nucleotide polymorphisms and methods for their use, for example, in diagnosing Down Syndrome. |
| US08609337B2 |
Nucleic acid detection and quantification by post-hybridization labeling and universal encoding
The present invention provides, among other things, methods and compositions for encoding a substrate for detecting and quantifying target nucleic acids. |
| US08609334B2 |
Biomarkers for painful intervertebral discs and methods of use thereof
The present disclosure provides methods of diagnosing painful intervertebral discs. The present disclosure also provides methods of treating a painful intervertebral disc. |
| US08609333B2 |
Detection of methylated DNA and DNA mutations
The present invention relates to various methods of detecting DNA methylation and defected DNA. In one embodiment, the invention provides a nanosensor bound to a probe that is complementary to a DNA methylation sequence. |
| US08609329B2 |
FRET-based assay for screening modulators of receptor cycling
Automated FRET imaging of membrane-bound receptor/ligand complexes can discriminate between a clustered organization of ligand/receptor complexes that occurs during the early endocytic stages following internalization and a random distribution characteristic of late stage disassociation of ligand from the receptor. In the case of the low density lipoprotein receptor (LDL-R) and its ligand, LDL, this feature of FRET imaging forms the basis of an assay to monitor the endosomal release of cholesterol into the cell and identify compounds which alter pH in the endosome thereby inhibiting the disassociation of ligand and cholesterol from the receptor, a mechanism that is involved in regulation of plasma/serum cholesterol. |
| US08609327B2 |
Forming sub-lithographic patterns using double exposure
Methods are presented of forming sub-lithographic patterns using double exposure. One method may include providing a photoresist layer over a layer to be patterned; exposing the photoresist layer using a first mask having a first opening; developing the photoresist layer to transfer the first opening into the photoresist layer, forming a boundary in the photoresist layer about the transferred first opening that is hardened; exposing the photoresist layer using a second mask having a second opening that overlaps the boundary; and developing the photoresist layer to transfer the second opening into the photoresist layer, leaving the boundary, wherein the boundary has a sub-lithographic dimension. |
| US08609318B2 |
Radiation-sensitive resin composition, method for forming resist pattern and polymer
A radiation-sensitive resin composition includes (A) a polymer that includes a structural unit (I) including a group shown by the following formula (i), (B) a photoacid generator, and (C) a polymer that has a fluorine atom content lower than that of the polymer (A), and includes an acid-labile group. The polymer (A) preferably includes a structural unit shown by the following formula (1) as the structural unit (I). It is preferable that X in the formula (1) represent a divalent or trivalent chain-like hydrocarbon group or alicyclic hydrocarbon group. |
| US08609314B2 |
Developing agent and method of manufacturing the same
According to one embodiment, a method of manufacturing a color erasable developing agent including preparing a dispersion containing a fine particle containing a leuco dye and a developer, a fine particle containing a color erasing agent, a toner binder resin fine particle and a medium, aggregating the fine particles in the medium, and heat fusing the aggregate to form a toner particle is provided. |
| US08609312B2 |
Toner
A toner is provided which has toner particles containing a charging component and containing an aromatic compound represented by the following formula (1): wherein R1 to R3 each independently represent a hydrogen atom, a hydroxyl group, a carboxyl group, an alkyl group having 1 to 18 carbon atom(s) or an alkoxyl group having 1 to 18 carbon atom(s); R4 to R7 each independently represent a hydrogen atom, a hydroxyl group, an alkyl group having 1 to 18 carbon atom(s) or an alkoxyl group having 1 to 18 carbon atom(s); R8 represents a hydrogen atom or a methyl group; and m represents an integer of 1 to 3. |
| US08609308B1 |
Smart subfield method for E-beam lithography
The present disclosure provides a method of improving a layer to layer overlay error by an electron beam lithography system. The method includes generating a smart boundary of two subfields at the first pattern layer and obeying the smart boundary at all consecutive pattern layers. The same subfield is exposed by the same electron beam writer at all pattern layers. The overlay error caused by the different electron beam at different layer is improved. |
| US08609306B2 |
Method for forming circular patterns on a surface
A method for fracturing or mask data preparation for shaped beam charged particle beam lithography is disclosed, in which a square or nearly-square contact or via pattern is input, and a set of charged particle beam shots is determined which will form a circular or nearly-circular pattern on a surface, where the area of the circular or nearly-circular pattern is within a pre-determined tolerance of the area of the input square or nearly-square contact or via pattern. Methods for forming a pattern on a surface and for manufacturing a semiconductor device are also disclosed. |
| US08609299B2 |
Fuel cell sealing structure and manufacture method
A fuel cell seal structure includes a GDL which is formed by a porous body and a gasket which is integrally formed with a peripheral edge of a GDL. The GDL includes a rubber impregnation portion and an impregnation stopping portion. The gasket is integrally formed with a gasket body portion having a thickness dimension larger than a thickness dimension of the GDL and an overlap portion overlapping with the GDL in a plane other than a portion impregnated by the GDL. The rubber impregnation portion of the GDL includes an inner portion which is provided between the impregnation stopping portion and an outer portion overlapping with the overlap portion of the gasket in a plane so as not to overlap with the gasket in a plane. |
| US08609298B2 |
Form and fill subgasket
A method for manufacturing a subgasket for a fuel cell stack having a pair of plates disposed in a stack includes the step of positioning a membrane between the plates. The membrane includes an inboard portion and a tortuous form portion. The inboard portion abuts a proton exchange membrane of the fuel cell, and the tortuous form portion abuts each of the plates. The tortuous form portion defines at least one cavity between one of the plates and the membrane. A viscous sealant is injected into the cavity. The sealant is cured to form a compliant bead seal on the membrane. |
| US08609294B2 |
Method to provide electrical insulation between conductive plates of a hydrogen fuel cell
A subassembly for a fuel cell includes a fuel cell plate having a first side and a second side. Each of the first side and the second side has a flow field disposed between a pair of headers. An insulating spacer abuts the first side of the fuel cell plate and is disposed adjacent a perimeter of the fuel cell plate. A unitized electrode assembly includes a subgasket, a membrane electrode assembly, and a pair of diffusion medium layers. The membrane electrode assembly has an electrolyte membrane sandwiched between a pair of electrodes. The membrane electrode assembly is sandwiched between the pair of diffusion medium layers. The subgasket surrounds, and is coupled to, the membrane electrode assembly. The subgasket abuts the insulating spacer. An elastomeric seal abuts the second side of the fuel cell plate. |
| US08609279B2 |
Lithium secondary battery and method for producing same
A rechargeable lithium battery including a negative electrode made by depositing a noncrystalline thin film composed entirely or mainly of silicon on a current collector, a positive electrode and a nonaqueous electrolyte, characterized in that said nonaqueous electrolyte contains carbon dioxide dissolved therein. |
| US08609274B2 |
Nested heatsink housing for lithium ion cells
A cell housing includes a first half section having a longitudinal side having a first end and a second end. A first lateral side extends perpendicularly to the longitudinal side from the first end. The first lateral side has a first tongue. A second lateral side extends perpendicularly to the longitudinal side from the second end. The second lateral side has a first groove. A second half section is identical to the first half section. The first and second half sections are coupled to each other such that the first tongue of the first half section is inserted into the first groove of the second half section and the first tongue of the second half section is inserted into the first groove of the first half section, forming a closed perimeter. |
| US08609269B2 |
Cylindrical secondary battery including a cap-up
A cylindrical secondary battery including a cap-up in which a surface region of the cap-up that is to be connected to an external device is partially coated with an insulating agent. Due to the structure of the cap-up, an unusual discharge caused due to an unusual contact of the cap-up with an external conductor, or a short between a positive electrode and a negative electrode of the secondary battery may be prevented. |
| US08609266B2 |
Battery pack
A battery pack that prevents a short from being generated when an insulation film near coupling holes formed in the conforming cover is broken by the connection tab due to external impacts and penetrates into the wire while or after the connection tab is assembled with the conforming cover through the coupling holes. The battery pack includes battery cells, a connection tab connecting the battery cells to each other in series or parallel, a conforming cover having a wire and coupling holes formed at one side thereof to allow the connection tab to pass therethrough, the conforming cover electrically connected to the connection tab, a protection circuit module electrically connected to the conforming cover and controlling charging and discharging of the battery cells, and a reinforcing member surrounding at least both sides of upper and lower edges among outer peripheral portions of the coupling holes formed in the conforming cover. |
| US08609263B1 |
Systems and methods for forming magnetic media with an underlayer
Systems and methods for forming magnetic media with an underlayer are provided. One such method includes providing a non-magnetic substrate, forming a seed layer above the substrate, the seed layer including MgO, forming an underlayer on the seed layer, the underlayer including a material selected from the group consisting of Pd, Pt, W, Fe, V, Cu, and Ag, and forming a magnetic recording layer on the underlayer, the recording layer including FePt oxide. |
| US08609258B2 |
Light emitting devices and compositions
A light emitting composition includes a light-emitting iridium-functionalized nanoparticle, such as a compound of formula (I). The compound of formula (I) further comprises at least one host attached to the core. A light emitting device includes an anode, a cathode, and a layer containing such a light-emitting composition is also disclosed. In an embodiment, the light emitting device can emit white light. |
| US08609254B2 |
Microcrystalline anodic coatings and related methods therefor
Methods of preparing metal and metal alloys with partially microcrystalline anodic coatings are disclosed. Associated article therefrom are correspondingly disclosed. The partially microcrystalline anodic coatings exhibit steam, superheated steam, alkaline and acidic resistance. Partially microcrystalline anodic coating can be prepared by impregnation of micropores of a metal or metal substrate with metal precursor species, conversion of the metal precursor species into metal hydroxides, thermal treatment to dry out moisture and to promote phase transformation of the metal hydroxide product into metal oxides solids and bonding with metastable metal oxide substance in the pore structure of the metal or metal alloy substrate, and hydrothermal sealing to create sealed partially microcrystalline anodic coating. |
| US08609249B2 |
Thin wall expandable polymer tubes having improved axial and radial strength, and a method of manufacturing thereof
A method for making a thin walled ePTFE tube having improved axial and radial strength includes the steps of: providing an unsintered or partially sintered ePTFE membrane; wrapping the ePTFE membrane around a mandrel or form tool to form an ePTFE tube; matting the ePTFE tube; immediately thereafter, sintering the matted ePTFE tube; removing the sintered ePTFE tube from the mandrel or form tool; stretching the sintered ePTFE tube in the axial direction; stretching the ePTFE tube in the radial direction over a second mandrel that is greater in diameter than the reduced axially stretched diameter, but less than the first mandrel diameter; overwrapping the second mandrel with a second ePTFE membrane; matting the ePTFE tube; immediately thereafter, sintering the matted ePTFE tube; and removing the sintered ePTFE tube from the second mandrel or form tool. |
| US08609247B2 |
Capped particles comprising multi-block copolymers for use in lubricants
The present invention relates to additives for use in lubricant compositions to processes for producing the additives, and to the use of the additives in lubricants and in systems that are lubricated. More specifically, the additive includes a capped particle comprising: (i) one or more inorganic core particles; and (ii) one or more multi-block copolymers attached to the inorganic particles. The multi-block copolymer includes at least one nonpolar polymer block interposed between two polar polymer blocks. One polar polymer block is attached to the core particle, and at least a portion of the another polar polymer block is not directly attached to the core particle. When used in a lubricant to lubricate a metallic surface of a workpiece, the capped particle preferably adheres to the metallic surface of the workpiece. |
| US08609246B2 |
Electroconductive fine particles, anisotropic electroconductive material, and electroconductive connection structure
A conductive fine particle, which is used for conductive connection between fine electrodes and tends not to give rise to a crack in the solder layer or disconnection caused by breakage in the connection interface between an electrode and the conductive fine particle even with a drop impact and the like, and tends not to have fatigue even after repetitive heating and cooling; an anisotropic conductive material obtained by using the conductive fine particle; and a conductive connection structure. |
| US08609244B2 |
Engineered low-density heterogeneous microparticles and methods and formulations for producing the microparticles
A low density material and a method for preparing a low-density material and precursor for forming a low-density material are provided. An aqueous mixture of inorganic primary component and a blowing agent is formed, the mixture is dried and optionally ground to form an expandable precursor. Such a precursor is then fired with activation of the blowing agent being controlled such that it is activated within a predetermined optimal temperature range. The firing conditions are also controlled to provide a low density sphere containing a heterogeneous sphere wall structure comprising a combination of amorphous glass and a crystalline phase or gas phase or both. |
| US08609238B2 |
Method and material for a thermally crosslinkable random copolymer
A structure that comprises a substrate; a cross-linked random free radical copolymer on the substrate; and a self-assembled patterned diblock copolymer film on the random copolymer; wherein the random copolymer is energy neutral with respect to each block of the diblock copolymer film. A method of making the structure is provided. |
| US08609237B2 |
Composite materials and methods of making the same
The present invention provides composite materials that contain formaldehyde-free aqueous binder compositions comprising defatted soy flour of no greater than 43 micron mesh particle size and polymer particles of at least one emulsion (co)polymer. Preferably, the defatted soy flour is present as an aqueous dispersion, or is in denatured form. Also provided are methods of making and using composite materials containing the formaldehyde-free binder compositions. |
| US08609232B2 |
Low permeability rubber laminate and pneumatic tire using the same
A low permeability rubber laminate having an excellent bondability, air pressure retaining property and durability and containing (A) at least one low permeability resin layer having an average thickness d of 0.05 μm |
| US08609231B2 |
Composite laminates and uses thereof
The present invention generally relates to composite laminates and uses thereof in articles in need of protection from mechanical damage and water or oxygen based degradation. |
| US08609225B2 |
Ethylene-unsaturated ester copolymer film for forming laminate
The object of the present invention to provide an ethylene-unsaturated ester copolymer film used for forming a laminate, which is provided with emboss having effect on prevention on blocking during storage of the film, and which has good tackiness that is required for alignment in a laminating step. A film 40 for forming a laminate, which is formed from a composition comprising an ethylene-unsaturated ester copolymer and has emboss only on one surface 41 of the film, wherein a surface 42 opposite to the surface having emboss is provided with a fine asperity 43, the surface 42 provided with the fine asperity 43 having a surface roughness profile with a mean spacing between peaks (Sm) of 600 to 1600 μm and an arithmetical mean roughness (Ra) of 1.2 to 2.2 μm. |
| US08609223B2 |
Interfolded napkins and method for interfolding napkins
A rectangular stack of interfolded rectangular napkins including a plurality of napkins, each napkin in the stack comprising a first fold in a first direction, and a second fold in a second direction perpendicular to the first direction and bisecting the first fold and the napkin in the second direction, the intersecting first and second folds dividing the napkin into four panels with a pair of adjacent panels located on each side of the second fold, wherein each of the napkins within the stack includes at least one pair of panels arranged in the stack at a level between two pairs of adjacent panels of another of the absorbent napkins within the stack. |
| US08609214B1 |
Elastomeric film
A combination handheld device and anti-slip film is produced by combining a thin, dimensionally stable plastic film having a smooth surface finish with a silicone elastomer having a low durometer and a textured and polished surface finish. The film includes adhesive means for adhering the film to objects such as a handheld device. |
| US08609204B2 |
Apparatus and method for solid freeform fabrication
A Solid Freeform Fabrication system, apparatus and method is provided, that includes a movable fabrication tray adapted to hold an object being fabricated; a depositing surface to hold deposited materials, and ink jet printing heads to selectively deposit a plurality of building materials on the depositing surface; wherein the deposited materials are merged to the object being fabricated, when said fabrication tray moves said object being fabricated to be in contact with said deposited materials. |
| US08609203B2 |
Method and apparatus for plasma surface treatment of moving substrate
A method and apparatus for treatment of a substrate surface using an atmospheric pressure plasma is disclosed. The method comprises providing an atmospheric pressure plasma in a treatment space between a first electrode and a second electrode, providing a substrate in contact with the first electrode in the treatment space, and applying a plasma generating power to the first and second electrodes. The first electrode has a predefined structure of insulating areas and conductive areas for plasma treatment of surface areas of the substrate corresponding to the areas in contact with the conductive areas of the first electrode. |
| US08609199B2 |
Carbon nanotube growing process, and carbon nanotube bundle formed substrate
In the growth of carbon nanotubes, the aggregation of catalytic fine particles therefor is a problem. In order to realize the growth of carbon nanotubes into a high density, the carbon nanotube growing process includes a first plasma treatment step of treating a surface having catalytic fine particles with a plasma species generated from a gas which contains at least hydrogen or a rare gas without carbon element, a second plasma treatment step of forming a carbon layer on the surface of the catalytic fine particles by a plasma generated from a gas which contains at least a hydrocarbon after the first plasma treatment step, and a carbon nanotube growing step of growing carbon nanotubes by use of a plasma generated from a gas which contains at least a hydrocarbon after the second plasma treatment step. |
| US08609197B1 |
Preparing glass containers for electrostatic coating
A glass container and related methods of manufacturing and coating glass containers. The container includes a hot end coating that is deposited on an exterior surface and that includes a metal oxide, and a dopant to reduce electrical resistivity of the exterior surface of the container. The container also includes an organic coating electrostatically applied to the exterior surface of the container. Preferably, the organic coating is applied at an ambient temperature and without having to use grounding pins, without having to heat the container, and without having to apply an additional conductive coating layer. |
| US08609192B2 |
Method and device for controlling oxidizing-reducing of the surface of a steel strip running continuously through a radiant tubes furnace for its galvanizing
A method for guaranteeing the oxidation of a strip designed to prevent the selective oxidation of alloy elements of the steel in a continuous steel strip galvanizing annealing furnace having a pre-heating section and a hold section and provided only with radiant tubes. The oxidation of the strip is designed to prevent the selective oxidation of elements of the steel alloy. The novel method includes the following steps: installation of at least one modified tube capable of injection an oxidizing medium at least one point in the oven heating section and/or at least one point in the hold section and injection of the oxidizing medium by means of the modified tube(s), the oxidizing medium having a composition such that in the conditions of the temperature of the oxidizing medium and the steel strip and as a function of the chemical composition of the strip said medium has a dew point which guarantees an in-depth oxidation of the alloy elements of the steel strip. |
| US08609187B1 |
Method of producing an oxide dispersion strengthened coating and micro-channels
The disclosure provides a method for the production of composite particles utilizing a mechano chemical bonding process following by high energy ball milling on a powder mixture comprised of coating particles, first host particles, and second host particles. The composite particles formed have a grain size of less than one micron with grains generally characterized by a uniformly dispersed coating material and a mix of first material and second material intermetallics. The method disclosed is particularly useful for the fabrication of oxide dispersion strengthened coatings, for example using a powder mixture comprised of Y2O3, Cr, Ni, and Al. This particular powder mixture may be subjected to the MCB process for a period generally less than one hour following by high energy ball milling for a period as short as 2 hours. After application by cold spraying, the composite particles may be heat treated to generate an oxide-dispersion strengthened coating. |
| US08609186B2 |
Method for manufacturing coating film
The presently disclosed subject matter provides a method for manufacturing a coating film whereby a problem of planarity in a plastic film wound up into a roll form can be eliminated and the coating film can be formed uniformly and precisely. There is therefore provided a method for manufacturing a coating film in which a plastic film wound into a roll form is wound off to be allowed to run and is fed while winding the film around a heat roller so as to eliminate deformations in the plastic film, and then a coating liquid is applied onto the plastic film, wherein in a position where wrinkles begin to form in the plastic film due to heating by the heat roller, the plastic film is pneumatically pressed by air jetted from an air nozzle at a pressure equal to or higher than a pressure at which the wrinkles disappear. |
| US08609182B2 |
Solution containment during buffer layer deposition
Improved methods and apparatus for forming thin-film layers of chalcogenide on a substrate web. Solutions containing the reactants for the chalcogenide layer may be contained substantially to the front surface of the web, controlling the boundaries of the reaction and avoiding undesired deposition of chalcogenide upon the back side of the web. |
| US08609178B2 |
Substrates for spatially selective micron and nanometer scale deposition and combinatorial modification and fabrication
A substrate (1) for spatially selective micron and nanometer scale deposition and/or reaction, which has a support (3), a conductive layer (5) on the support, a dielectric layer (7) to hold an electrostatic charge pattern such as a photoconductive layer of a material which dissipates an electric charge upon receiving incident radiation thereon, and a chemically functional layer (9), such that electrostatic charge patterns may be formed in a predetermined manner upon the substrate to influence the movement of charged droplets in an emulsion (15) on the substrate. The chemically functional layer either provides a surface for chemical functionalization of the substrate or prevents access or reaction to the dielectric or photoconductive layer. |
| US08609177B2 |
Production of canola protein product without heat treatment (“C200CaC”)
The supernatant from the deposition of canola protein micellar mass is processed to provide a canola protein product having a protein content of about 60 to less than about 90 wt % (N×6.25) protein on a dry weight basis and which is soluble in an aqueous acidic environment. |
| US08609176B2 |
Food composition
A food composition is provided useful for decreasing the amount of sodium while maintaining a high perceived saltiness of the food composition. The food composition comprises a particulate phase and a soluble phase and a selective sodium distribution between the phases whereby the amount of sodium in the particulate phase is at least 4 wt %, more preferably at least 10 wt %, more preferably at least 15 wt % and most preferably at least 20 wt %, and preferably at most 99.99 wt %, more preferably at most 99 wt %, more preferably at most 90 wt %, most preferably at most 70 wt % by weight of the total amount of sodium in the particulate and soluble phase. |
| US08609175B2 |
Method of reducing the saturated fatty acid content of milk fat
The present invention is related to a method for reducing the saturated fatty acid content of milk fat. The milk fat is subjected to fractional crystallization to recover an olein fraction. Then the olein fraction is subjected to short path distillation to obtain a residual milk fat fraction that has not been evaporated and has a reduced saturated fatty acid content. |
| US08609173B2 |
Compositions comprising sweetness enhancers and methods of making them
The present invention provides solid and liquid compositions comprising 5-(neopentyloxy)-1H-benzo[c][1,2,6]thiadiazin-4-amino-2,2-dioxide or 3-(4-amino-2,2-dioxide-1H-benzo[c][1,2,6]thiadiazin-5-yloxy)-2′,2′-dimethyl-N-propylpropanamide, and methods of making the compositions by spray drying and spin melting. The present invention also provides ingestible compositions comprising compositions of the present invention and methods of making such foods. |
| US08609170B2 |
Method for beverage formation with automated water delivery to heating tank
A method and apparatus for forming a beverage using a beverage formation device. Opening of a brew chamber may automatically enable the provision of beverage precursor liquid from a reservoir to a heating tank that is used (heated or not) to form a beverage. For example, opening of the brew chamber may cause a valve to be opened or otherwise permit flow of beverage precursor liquid from the reservoir to the heating tank. The valve may open simultaneously and automatically with a brew chamber lid, and may close when the brew chamber lid is closed. |
| US08609169B2 |
Methods for preserving fresh produce
Methods of preserving fresh produce with a produce preservative, particularly cut fresh produce, are provided. The method comprises: providing a solution of produce preservative comprising: water; a preservative cation which is selected from the group consisting of a strontium ion, lithium ion, barium ion, aluminum ion, copper ion, ammonium ion, iron ion, manganese ion, potassium ion, or mixtures thereof; and ascorbate ions, or erythorbate ions; wherein the ascorbate ions or erythorbate ions and the preservative cation are present in an ion ratio of preferably from 0.2:1 to 8:1, more preferably 0.75:1 to 8:1, even more preferably from 1:1 to 4:1, yet more preferably 1.5:1 to 3:1; most preferably 1.1:1 to 2.5:1; and, applying said produce preservative to the produce. The invention also relates to fresh produce preserved with the produce preservatives. |
| US08609168B2 |
Food cooking control method and device
The invention relates to a food cooking control method and device. The method includes the following steps in which: at least one temperature detection device is inserted into a food; a final equilibrium temperature is defined; the detection device is positioned inside the food in a pre-determined detection zone so that a temperature (TC) can be obtained at all times during cooking; the TC temperature data obtained are processed using the detection device; the temperature of the surface through which the food receives heat (TP) is determined and processed and the variation in temperature TC is evaluated at least to the first derivative. The device includes a detection device intended to be inserted into the food, a device for determining the thickness of the food and a device for inserting the detection device into the food to a pre-determined depth. |
| US08609163B2 |
Herbal formulation advocated for the prevention and management of coronary heart disease
According to this invention there a novel herbal formulation for the prevention and management of coronary heart disease and associated CHD risk factors, comprising, preparing a hydromethanolic extract of at least two plants selected from of Withania somnifera, Costus speciosus, Hippophae rhamnoides and Terminalia arjuna at 60-80° C., maintaining the pH of the solution between 7-10, separating the active compounds chromatographically, subjecting the active compounds to the step of molecular characterization. |
| US08609158B2 |
Diane's manna
This is a potent drug with narcotic benefits made from distinctly and uniquely combined and processed interchangeable seed and seed derivatives that are so potent that it removes or alleviates depression, mood disorders, Attention Disorder symptoms, thought disorder, mental illness, pain, right lip retardation symptoms, physical problems, Lymph Node cancer and many other illness symptoms. It removes bumps in the neck within a week or two. It is interchangeable in most aspects. It can be combined and processed with Pharmaceuticals and medicines to create new drugs. These Pharmaceuticals are now long lasting. I prefer the daily dose, but this drug can last months. It is extremely strong or potent and can be made weak to make your little Attention deficit child normal. It is an incredible mood stabilizer and reduces psychosis. Use it for cancer patient and for people with pain issues. It works. |
| US08609156B2 |
Compositions and methods of treatment that include plant extracts
The present invention provides for a pharmaceutical composition that provides for the symptomatic relief to an animal (e.g., mammal, such as a human) afflicted with inflammation. The pharmaceutical composition includes a pharmaceutically acceptable carrier and at least two of: (a) sunflower extract, (b) rhubarb root extract, (c) milk thistle extract, (d) dandelion extract, (e) feverfew extract, and (f) ginger extract. The present invention also provides for a method for providing symptomatic relief to a human afflicted with inflammation. The method includes administering to a patient in need of such symptomatic relief an effective amount of the pharmaceutical composition described herein, for a period of time sufficient to provide symptomatic relief to the human. |
| US08609148B2 |
Methods of therapeutic treatment of eyes
Provided are electrokinetically-altered aqueous fluids (e.g., gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating an irritation, infection or inflammatory eye condition, comprising administering to, by contacting the eye of a subject in need thereof a therapeutically effective amount of an electrokinetically-altered aqueous fluid. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids) and therapeutic compositions for use in treating eye conditions. Certain embodiments relate to cosmetic and/or therapeutic fluids and/or methods of treatment utilizing the fluids to treat a cosmetic and/or therapeutic symptom related to eye conditions and/or diseases. |
| US08609144B2 |
Sustained release intraocular implants and methods for preventing retinal dysfunction
Biocompatible intraocular microspheres and implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat or to prevent the occurrence of one or more ocular conditions, to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like, to enhance normal retinal function and/or to lower intraocular pressure. |
| US08609143B2 |
Morphine polymer release system
A pharmaceutical composition for controlled release of an active substance is provided. The active substance is released into an aqueous medium by erosion of at least one surface of the composition. The composition comprises i) a matrix comprising a) polymer or a mixture of polymers, b) an active substance and, optionally, c) one or more pharmaceutically acceptable excipients, and ii) a coating. |
| US08609140B2 |
Calcium carbonate granulation
Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available. |
| US08609138B2 |
ω3 fatty acid compound preparation
Provided is a compound preparation including at least one selected from the group consisting of ω3 polyunsaturated fatty acids and pharmaceutically acceptable salts and esters thereof and at least one selected from the group consisting of statin compounds and pharmaceutically acceptable salts thereof. The compound preparation is in a form of a soft capsule having a capsule coating with a pH of 7.0 to 9.5. The compound preparation suppresses the decomposition of the statin compounds and/or the modification/insolubilization of the capsule coating. A medical use for the compound preparation, a method of manufacturing the compound preparation and a method of using the compound preparation are also provided. |
| US08609137B2 |
Soft capsule of butylphthalide and a process for preparing the same
The present invention discloses a novel soft capsule of butylphthalide and a process for preparing the same. The soft capsule of butylphthalide is composed of a capsule wall material and a drug-containing oil, wherein the drug-containing oil is essentially composed of butylphthalide and a vegetable oil as the diluent in a weight ratio of about 1:0˜10. The capsule wall material is composed of a capsule wall matrix, a plasticizer and water in a weight ratio of 1:0.2˜0.4:0.8˜1.3. The soft capsule of butylphthalide described in the present invention can mask the strong and special flavor of butylphthalide, and overcome the difficulties associated with formulating oily active ingredient into other oral formulation. The disintegration time of the soft capsule satisfies the requirement of Pharmacopoeia of P.R. China. |
| US08609134B2 |
Methods of transdermally administering an indole serotonin receptor agonist and transdermal compositions for use in the same
Methods of transdermally delivering a therapeutic amount of an indole serotonin receptor agonist to an individual in need thereof, e.g., to provide a therapeutic level of an indole serotonin receptor agonist to an individual in need thereof, are provided. Also provided are transdermal formulations of indole serotonin receptor agonists that find use in practicing the subject methods. |
| US08609130B2 |
Method for activating hemostatic systems by applying a hemostatic textile
The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and/or glycolide polymers; lactide/glycolide copolymers; silicate fibers; polyamide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding. |
| US08609128B2 |
Cyanoacrylate-based liquid microbial sealant drape
The invention relates to methods of using compositions for forming microbial sealant drapes. In particular, the invention relates to the use of compositions of combinations of cyanoacrylates for the in situ formation of drapes that can be used in surgery to protect patients from surgical site infections. |
| US08609124B2 |
System and methods of maintaining space for augmentation of the alveolar ridge
An implantable screw for maintaining space during bone grafting procedures is provided, where the screw has a highly-polished contoured head having a region adapted to support soft tissue, a threaded shaft and a tip adapted to penetrate bone tissue. Also provided, a device combining multiple implantable screws in series in order to increase the available space to grow new bone and a method for implanting the implantable screw. The implantable screws provided may be used in conjunction with bone graft materials and are removable once a desired amount of new bone is generated. |
| US08609123B2 |
Derivatized poly(ester amide) as a biobeneficial coating
A derivatized poly(ester amide) (D-PEA) and coatings and medical devices formed therefrom are provided. The coatings and medical devices may optionally include a biobeneficial material and/or a biocompatible polymer and/or a bioactive agent. The medical devices can be implanted in a patient to treat, prevent, or ameliorate a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof. |
| US08609120B2 |
Use and generation of ozone as a disinfectant of dairy animal tissues, dairy equipment, and infrastructure
An ozone delivery system, method, and apparatus are disclosed. Ozonated water can be used to disinfect and clean various surfaces, equipment, and animals in a dairy setting. Animals can be disinfected and protected from disease through the use of wash-pen and sprayer injections, and other footbath products. Ozone can be educted into a drop hose and a pre-dip line at periodic intervals and into a foot bath to provide refreshed ozonated water. The ozone delivery system and method sterilizes all equipment and floor surfaces without damaging diary equipment components. The system can incorporate computer-controlled options such as maintaining off gas levels, maintaining cleaning and disinfecting records, monitoring ozonated water levels, monitoring concentrations of ozone in said ozonated water, controlling entry and exit gates, controlling a drainage system, and monitoring and educting ozone in a foot bath and wash pen. |
| US08609112B2 |
Botulinum toxin treatments of depression
Methods for preventing or treating depression including a depression mediated by the thalamus. Depression, including a thalamically mediated depression, can be treated by peripheral administration of a botulinum toxin to or to the vicinity of a trigeminal sensory nerve, thereby preventing or treating the depression. |
| US08609111B2 |
Antibodies against clostridium difficile toxins and uses thereof
Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein. |
| US08609110B2 |
Citrobacter freundii antibacterial agents and their use
Provided herein are methods for treating planktonic bacteria or a biofilm. The methods include contacting the planktonic bacteria or biofilm with an effective amount of an isolated Citrobacter freundii colicin A polypeptide, wherein the polypeptide has an antibacterial activity against the planktonic bacteria or the biofilm. Methods are also provided herein for treating a subject that has a bacterial infection, for example caused by a biofilm. The methods can be used to treat a biofilm on a living or non-living surface. Also provided herein are Citrobacter freundii colicin A polypeptides that have an antibacterial activity against planktonic bacteria or surface attached bacteria, and nucleic acid sequences encoding the polypeptides. Medical devices comprising a surface having an antimicrobial effective amount of a Citrobacter freundii colicin A polypeptide, or a nucleic acid molecule encoding the polypeptide, are also disclosed. |
| US08609109B2 |
HIV vaccine formulations
Provided herein are HIV vaccines comprising HIV polypeptide-encoding DNA adsorbed to PLG and/or HIV proteins. Also provided are methods of using these vaccines to generate immune responses in a subject. |
| US08609108B2 |
Gamma-glutamyl transpeptidase attenuated Francisella
The present invention relates to a mutated Francisella bacterium, wherein the ggt gene is silenced or deleted; pharmaceutical compositions comprising the same, in particular, vaccine compositions, and use of the bacterium and compositions for treatment and/or prophylaxis, and in particular, the treatment or prophylaxis of tularemia. |
| US08609107B2 |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
The invention provides methods of treating subject with polypeptides having at least 80% identity to SEQ ID NO: 5326. The methods stimulate an immune response in the subject and provide methods for prevention and treatment of pathological conditions resulting from bacterial infection. |
| US08609104B2 |
Treatment of B-cell cancers with anti-CD70 antibody-drug conjugates
Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of a CD70-expressing cancer, comprising administering to a subject the disclosed pharmaceutical compositions. |
| US08609100B2 |
Method for inhibiting dendritic cell immunoreceptor (DCIR)-mediated human immunodeficiency virus infection comprising administering anti-DCIR antibodies
A cell surface molecule designated DCIR (for dendritic cells ImmunoReceptor), a member of a recently described family of DC-expressing C-type lectin receptors, has been shown to participate to the capture of human immunodeficiency virus (HIV) and promote infection in trans and in cis of autologous CD4(+) T cells from human immature monocyte-derived DC. The contribution of DCIR to these processes was revealed using DCIR-specific siRNAs and a polyclonal antibody specific for the carbohydrate recognition domain of DCIR. Therapeutic agents for HIV infection are therefore provided herein. These therapeutic agents are useful for impairing the interaction between DCIR and HIV and as such may be useful for treatment or prevention of HIV infection. Also provided are assays for identifying additional therapeutics agents for treatment or prevention HIV infection. |
| US08609096B2 |
Monoclonal antibodies against PCBP-1 antigens, and uses therefor
The present invention provides and includes monoclonal antibodies (MoAbs or mAbs) specific or preferentially selective for PCBP-1 antigens, hybridoma lines that secrete these PCBP-1 antibodies or antibody fragments, and the use of such antibodies and antibody fragments to detect PCBP-1 antigens, particularly those expressed by cancer cells. The present invention also includes antibodies that are specific for or show preferential binding to a soluble form of PCBP-1. The present invention further includes chimeric and humanized antibodies, processes for producing monoclonal, chimeric, and humanized antibodies using recombinant DNA technology, and their therapeutic uses, particularly in the treatment of cancer. The present invention further includes methods and kits for the immunodetection and immunotherapy of cells for samples which express PCBP-1 antigens. |
| US08609095B2 |
Anti-HER2 antibodies and compositions
The present invention relates to novel therapeutic antibodies directed against HER2 (ErbB2), as well as recombinant polyclonal anti-HER2 antibody compositions comprising at least two of said recombinant anti-HER2 antibodies, and use of the antibodies and antibody compositions for treatment of cancer. |
| US08609089B2 |
Compositions of PD-1 antagonists and methods of use
Methods of treating cancer and infectious diseases utilizing a treatment regimen comprising administering a compound that reduces inhibitory signal transduction in T cells, in combination with a potentiating agent, such as cyclophosphamide, to produce potent T cell mediated responses, are described. Compositions comprising the PD-1 antagonists and potentiating agents useful in the methods of the invention are also disclosed. |
| US08609087B2 |
Compounds and methods for identifying compounds which inhibit a new class of aspartyl proteases
Compounds and methods for designing and identifying compounds which inhibit TFPP-like aspartyl protease enzymes by targeting the aspartic acid residues of the active site or mimicking peptides corresponding to the region surrounding the substrate's cleavage site are provided. Agents identified as inhibitors of TFPP-like aspartyl proteases such as type 4 prepilin peptidases are expected to be useful as anti-bacterial agents and in inhibiting development of drug resistant strains of bacteria. |
| US08609085B2 |
Use of gingival fibroblasts for vascular cell therapy
The invention relates to the use of gingival fibroblasts for obtaining a cellular composition for treating arterial-remodelling pathology, for example an aneurysm, post-cryoplasty stenosis and restenosis, an aortic dissection or atherosclerosis. |
| US08609082B2 |
Administering bone marrow progenitor cells or myoblasts followed by application of an electrical current for cardiac repair, increasing blood supply or enhancing angiogenesis
A method is provided including selecting a patient suffering from a condition, administering cells to the patient selected from the group consisting of: progenitor cells and genetically-modified cells, applying an electrical current to a site of the patient in a vicinity of nervous tissue, and configuring the current to stimulate the nervous tissue. Other embodiments are also described. |
| US08609079B2 |
Longwearing, transfer resistant cosmetic compositions having a unique creamy texture and feel
The present invention is directed to a long wearing, transfer resistant cosmetic composition which is waterproof, comfortable and has a unique creamy texture and feel containing: (a) a reaction product of (i) at least one polyamine and (ii) at least one oil soluble high carbon polar modified polymer; (b) water; (c) at least one volatile solvent capable of solubilizing the polar modified polymer; (d) optionally at least one non-volatile solvent; and (e) optionally, at least one colorant. |
| US08609078B2 |
Composition for shaping keratin fibers containing starches modified with propylene oxide
Cosmetic agents for temporary deformation of keratinic fibers containing, in a cosmetic carrier, at least one starch modified with propylene oxide and having an average molecular weight (weight average) of from 50 to 2500 kDa, the agents enabling a hairstyle with strong hold and high flexibility. Starches modified with propylene oxide are based on renewable raw materials. In this way, effective styling products for hair are provided without having to use raw materials based on fossil fuels. |
| US08609075B2 |
Heparanase activity inhibitor
A heparanase activity inhibitor comprising, as an active ingredient, a cyclic carboxamide derivative represented by formula (I): wherein n is an integer of 1 to 3, R1 is hydrogen or a C1-6 hydrocarbon group optionally substituted with hydroxyl, X is —CH2— or a group represented by —N(R2)—, and R2 is hydrogen or a C1-6 hydrocarbon group optionally substituted with hydroxyl, or a salt thereof. |
| US08609060B1 |
Method of producing carbon coated nano- and micron-scale particles
A method of making carbon-coated nano- or micron-scale particles comprising entraining particles in an aerosol gas, providing a carbon-containing gas, providing a plasma gas, mixing the aerosol gas, the carbon-containing gas, and the plasma gas proximate a torch, bombarding the mixed gases with microwaves, and collecting resulting carbon-coated nano- or micron-scale particles. |
| US08609056B2 |
Iron(III) orthophosphate for Li ion accumulators
Iron(III) orthophosphate of the general formula FePO4×nH2O (n≦2.5), prepared by a process in which iron(II)-, iron(III)- or mixed iron(II, III) compounds selected from among hydroxides, oxides, oxidehydroxides, oxide hydrates, carbonates and hydroxidecarbonates are reacted with phosphoric acid having a concentration in the range from 5% to 50%, any iron(II) present after the reaction is converted into iron(III) by addition of an oxidant and solid iron(III) orthophosphate is separated off from the reaction mixture. |
| US08609055B2 |
Method of producing fluoroapatite, fluoroapatite, and adsorption apparatus
A method of producing fluoroapatite by using a calcium-based compound containing calcium, hydrogen fluoride and phosphoric acid is provided. The method can be produced fluoroapatite having improved acid resistance by reducing an amount of an impurity derived from a raw material to a low or very low level, and ability capable of separating a large amount of a protein due to a large specific surface area thereof. Further, fluoroapatite having high acid resistance and a large specific surface area is also provided. Furthermore, an adsorption apparatus using such fluoroapatite is also provided. |
| US08609054B2 |
Hydrogen production from borohydrides and glycerol
A method of forming hydrogen gas comprises the steps of providing a reactor and providing a hydrogen-generating composition to the reactor. The hydrogen-generating composition consists essentially of a borohydride component and a glycerol component. The borohydride, e.g. sodium borohydride, and glycerol components are present in a generally three (3) to four (4) stoichiometric ratio, prior to reaction. The borohydride component has hydrogen atoms and the glycerol component has hydroxyl groups with hydrogen atoms. The method further comprises the step of reacting the borohydride component with the glycerol component thereby converting substantially all of the hydrogen atoms present in the borohydride component and substantially all of the hydrogen atoms present in the hydroxyl groups of the glycerol component to form the hydrogen gas. The reaction between the borohydride component and the glycerol component is an alcoholysis reaction. Reactors and reaction systems employing the method of the present invention are also described. |
| US08609053B2 |
Process for preparing of nanowires of metal oxides with dopants in lower valence state
The present invention provides a process for the preparation of nanowires of metal oxides with dopant elements in lower valence state. The nanomaterials/materials with dopants in lower valence state are important as these exhibit markedly different characteristics than higher valence state materials of same composition. Nanowires show markedly enhanced properties in lateral direction. The invented process presents a procedure for preparation of different types of nanowires in oxide form that are useful for different applications. In this a precursor is ignited in a specially designed container/enclosure that produces the product with the described features. The process is simple and involves a single step/stage is of very short time per batch. The invention provides a process, which gives controlled size of nanowires and is suitable for the production of nanowires/nanomaterials of desired metal oxides with dopant elements in valence state. |
| US08609051B2 |
Catalyst composition useful in the catalytic reduction of sulfur compound contained in a gas stream and a method of making and using such composition
Disclosed is a composition useful in the hydrolysis of sulfur compounds that are contained in a gas stream. The composition comprises alumina, a group VI metal component and a group VIII metal component. The composition has a pore structure such that a large percentage of its total pore volume is contained within the pores having a pore diameter greater than 10,000 angstroms. |
| US08609049B2 |
Vapour suppression additive
A process for removing CO2 from a CO2 containing gas stream in which the CO2 containing gas stream is contacted with an aqueous ammonium solution. The aqueous ammonia solution comprises 0.1-40% w/v, v/v/w/w ammonia, and a soluble salt at a concentration range of 0.01%-10% wt or v/v or w/v, the soluble salt having cations selected from the group of group IA, IIA, IIIA and IVA metals with counter anions selected from the group of anion of group VIIA elements, NO3−, SO42−, OH−, PO43− and HCO3−. The invention also extends to a CO2 capture solvent comprising an aqueous ammonia solution and the above soluble salt. |
| US08609048B1 |
Process for reducing corrosion, fouling, solvent degradation, or zeolite degradation in a process unit
A process for process for reducing one or more of corrosion, fouling, solvent degradation, or zeolite degradation in a process unit is described. The process includes introducing the hydrocarbon feedstream containing oxygen to an adsorbent bed containing copper and reacting the oxygen with the copper to form copper oxide and a reduced oxygen feedstream, and introducing the reduced oxygen feedstream into the process unit. A process for reducing one or more of corrosion, fouling, solvent degradation, or zeolite degradation in an aromatics extraction unit is also described. |
| US08609045B1 |
Mercury monitoring system and reaction chamber for enhancing conversion of elemental mercury gas into oxidized mercury
A reaction chamber enables a reaction between received elemental mercury gas and an oxidizing agent gas. The reaction chamber includes a porous (or permeable) medium through which to pass the elemental mercury gas and the oxidizing agent gas. Passing of the elemental mercury gas and the oxidizing agent gas through the porous medium supports a number of useful functions. For example, the porous medium enhances mixing of the elemental mercury gas with the oxidizing agent gas to enhance a reaction. Also, the porous medium increases an amount of surface area in a reaction chamber on which reactions (e.g., heterogeneous surface reactions) can take place between the elemental mercury gas and the oxidizing agent gas to form oxidized mercury gas. Accordingly, the reaction chamber configured to include a porous medium enhances a conversion of elemental mercury gas into oxidized mercury gas. |
| US08609032B2 |
Porous ceramic honeycomb articles and methods for making the same
A porous ceramic honeycomb article comprising a honeycomb body formed from cordierite ceramic, wherein the honeycomb body has a porosity P %≧55% and a cell channel density CD ≧150 cpsi. The porous channel walls have a wall thickness T, wherein (11+(300−CD)*0.03)≧T≧(8+(300−CD)*0.02), a median pore size ≦20 microns, and a pore size distribution with a d-factor of ≦0.35. The honeycomb body has a specific pore volume of VP≦0.22. The porous ceramic honeycomb article exhibits a coated pressure drop increase of ≦8 kPa at a flow rate of 26.5 cubic feet per minute when coated with 100 g/L of a washcoat catalyst and loaded with 5 g/L of soot. |
| US08609028B2 |
Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. |
| US08609027B2 |
Air cleaning filter comprising protein deactivating agent and process for producing same
The present invention relates to an air cleaning filter including a carrier provided therein including a protein deactivating agent coated thereon for removing or sterilizing bacteria, fungi, or virus in the air. The present invention also relates to an air cleaning filter further including kimchi lactic acid bacteria and a disinfectant. The present invention also relates to an air cleaning filter further includes fermented Ecklonia cava extract in addition to kimchi lactic acid bacteria and a disinfectant. The air cleaning filter according to the present invention is produced by a method including the step of coating and immobilizing a protein deactivating agent on a carrier, or depending on need, the step of coating and immobilizing a protein deactivating agent, kimchi lactic acid bacteria and a disinfectant on a carrier, or the step of coating and immobilizing a protein deactivating agent, kimchi lactic acid bacteria, a disinfectant and fermented Ecklonia cava extract on a carrier. Or, the air cleaning filter of the present invention includes the step of coating a coating solution on the carrier, the coating solution including protein deactivating agent; the protein deactivating agent, kimchi lactic acid bacteria and disinfectant; or the protein deactivating agent, kimchi lactic acid bacteria, disinfectant, fermented Ecklonia cava extract, wherein the binder is selected from a group including the silicon modified acryl resin, silicon modified epoxy resin, urethane resin, acryl resin, and silicon resin, and, the step of drying the carrier coated thus, whereby permitting to clean air effectively by removing or sterilizing bacteria, fungi, and virus in the air. |
| US08609026B2 |
Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide. |
| US08609024B2 |
System and method for automatically venting and sampling a culture specimen container
Apparatus for automated venting and/or sampling of a specimen container is disclosed. The apparatus includes a rack holding the specimen container; a venting and/or sampling device having a needle, a chamber in fluid communication with the needle and a port in fluid communication with the chamber; a robotic transfer mechanism moveable relative to the rack; a sample removal apparatus attached to the robotic transfer mechanism having gripping features for gripping the venting device. The sample removal apparatus and robotic transfer mechanism are moveable relative to the specimen container so as to automatically insert the needle of the venting device through the closure of the specimen container to thereby vent the interior of the specimen container and obtain equilibrium between the interior of the specimen container and the atmosphere and withdraw a portion of the sample from the specimen container into the venting and/or sampling device. |
| US08609018B2 |
Electrode for supercapacitor having manganese oxide-conductive metal oxide composite layer, fabrication method thereof, and supercapacitor comprising same
The present invention provides an electrode for a supercapacitor, a fabrication method thereof, and a supercapacitor comprising the same. The electrode exhibits enhanced specific capacitance and electrical conductivity, among others, due to the fact that it comprises a porous composite metal oxide layer which has the structure of a web of entangled nanofibers or has a nanoparticle network structure. |
| US08609017B2 |
Electronically tunable, low-loss ceramic materials including a tunable dielectric phase and multiple metal oxide phases
Electronically tunable dielectric materials having favorable properties are disclosed. The electronically tunable materials include an electronically tunable dielectric phase such as barium strontium titanate in combination with at least two additional metal oxide phases. The additional metal oxide phases may include, for example, oxides of Mg, Si, Ca, Zr, Ti and Al. The electronically tunable materials may be provided in bulk, thin film and thick film forms for use in devices such as phased array antennas, tunable filters and the like. The materials are useful in many applications, including the area of radio frequency engineering and design. |
| US08609016B2 |
Refoldable balloon and method of making and using the same
The present invention relates to a method of improving balloon refoldability by molding a preformed balloon into a larger, predetermined shape at a lower temperature and higher pressure than that with which the balloon was originally formed. |
| US08609013B2 |
Method of fabricating a microfabricated structure
Disclosed herein may be a photosensitive composition, a microfabricated structure including the same, a device including the microfabricated structure, and methods of fabricating the microfabricated structure and the device. The photosensitive composition, including a multifunctional photosensitive resin, a two-photon photosensitizer, an organic solvent, and a silver compound, may be subjected to two- or three-dimensional microfabrication, thus realizing the microfabricated structure containing silver nanoparticles. |
| US08609006B2 |
Pattern transfer apparatus and pattern forming method
The pattern transfer apparatus includes: a liquid ejection device having liquid ejection ports through which droplets of liquid are ejected and deposited onto a substrate surface while the liquid ejection device relatively moves to scan the substrate surface in a relative scanning direction; and a stamp having a stamp surface on which a pattern is formed, the stamp surface being applied to the droplets of the liquid on the substrate surface in a stamp application direction while the stamp is relatively moved with respect to the substrate, wherein when defining, on the substrate surface, strips which are straight and parallel to the stamp application direction and have widths substantially equal to diameters of the droplets deposited on the substrate surface, at least one of the strips includes the droplets which are ejected respectively from at least different two of the liquid ejection ports of the liquid ejection device. |
| US08609005B2 |
Stretched film of addition polymer consisting of norbornene compound, process for producing the same and use thereof
[Problems] To provide a stretched film of an addition polymer consisting of norbornene compounds favorable for use in manufacturing steps of electric insulating parts and optical parts that exhibits excellent film stability, does not suffer from coloration and has a low linear expansion coefficient.[Means for Solving Problems] A stretched film of an addition polymer consisting of norbornene compounds produced by stretching a film of the addition polymer consisting of norbornene compounds and having a linear expansion coefficient of at most 50 ppm/° C. The draw ratio is preferably from 1.2 times to 10 times. The stretched film is preferably a non-crosslinked film. A method for producing the stretched film comprises stretching a film of the addition polymer consisting of norbornene compounds at least in one direction in an inert gas atmosphere within a temperature range of the glass transition temperature (Tg) thereof ±50° C., or stretching a film of the addition polymer consisting of norbornene compounds containing an organic compound having a specific boiling point at least in one direction. |
| US08608996B2 |
Composite sheet materials and processes for manufacturing same
Provided are, among other things, systems, methods and techniques for manufacturing sheet material. In one representative embodiment, a sheet of fabric material is positioned across a patterning template that has a number of openings; and the sheet of fabric material and the patterning template are fed through an extrusion device in which extrusion material coats the fabric material and forces the fabric material into the openings in the patterning template, thereby producing a composite sheet material. |
| US08608988B2 |
Curable photochromic compositions and optical articles prepared therefrom
The present invention provides a curable, organic polymeric photochromic composition comprising: a photochromic amount of at least one photochromic material; a polymeric polyol having carbonate groups along its backbone and having a number average molecular weight greater than 5000 g/mole; and a curing agent having reactive functional groups capable of reacting with hydroxyl groups on the polymeric polyol. After curing and after the Photochromic Performance Test the composition demonstrates a T1/2 fade rate of less than 200 seconds.Also provided is a photochromic article comprising a rigid substrate and a photochromic organic polymeric coating applied to a surface of the substrate. The photochromic organic polymeric coating comprises the composition described above. |
| US08608987B2 |
High density lithium cobalt oxide for rechargeable batteries
The disclosure relates to positive electrode material used for Li-ion batteries, a precursor and process used for preparing such materials, and Li-ion battery using such material in its positive electrode. The disclosure describes a higher density LiCoO2 positive electrode material for lithium secondary batteries, with a specific surface area (BET) below 0.2 m2/g, and a volumetric median particle size (d50) of more than 15 μm. This product has improved specific capacity and rate-capability. Other embodiments of the disclosure are an aggregated Co(OH)2, which is used as a precursor, the electrode mix and the battery manufactured using above-mentioned LiCoO2. |
| US08608986B2 |
Metal complex, polymer compound and device containing those
Disclosed is a metal complex represented by the following formula (1). In the formula, M represents a metal atom; R1-R8 respectively represent a hydrogen atom, a halogen atom or a monovalent group; or alternatively R3 and R4, or R5 and R6 may combine together to form a ring. |
| US08608985B2 |
Anisotropic conductive film, composition for the same, and apparatus including the same
An anisotropic conductive film includes a binder part, a curing part, an initiator, and conductive particles, wherein the binder part includes at least one of a nitrile butadiene rubber (NBR) resin and a urethane resin, the binder part having an ion content of more than 0 ppm to about 100 ppm. |
| US08608984B1 |
Polymer nano-composites as dry sensor material for biosignal sensing
A multifunctional polymer nano-composite sensor system for detecting various biosignals like ECG and other kinds of signals for sensing strain, temperature and moisture has been disclosed. This sensor system includes (1) a polymer nano-composite sensor material that is flexible, elastic, soft, and conductive, (2) a sensor material fabricated into a desired shape or form, and (3) a signal capturing interface for collecting, transmitting and processing the signals. This sensor system can easily be integrated into a user environment for various user-transparent sensing applications. The present invention more specifically reveals a multi-functional nano-composite sensor for detecting biologically generated electrical signals which is comprised of a polymeric composition having an electrically conductive wire embedded therein, wherein the polymeric composition has a dispersion phase and a dispersed phase, wherein the dispersion phase is comprised of a thermoplastic polymer or a thermoset polymer, wherein the dispersed phase includes an electrically conductive filler, wherein the polymeric composition is gel-free, and wherein the electrically conductive wire is adapted for conveying an electrical signal to a signal processing device. The present invention further discloses a polymeric composition which is comprised of a thermoplastic polyurethane, a styrenic polymer, and at least one electrically conductive filler wherein the styrenic polymer is present in the composition at a level which is within the range of 10 weight percent to 50 weight percent and wherein the electrically conductive filler is present at a level which is within the range of 0.5 weight percent to 40 weight percent, based on the total weight of the polymeric composition. |
| US08608981B2 |
Methods for sulfate removal in liquid-phase catalytic hydrothermal gasification of biomass
Processing of wet biomass feedstock by liquid-phase catalytic hydrothermal gasification must address catalyst fouling and poisoning. One solution can involve heating the wet biomass with a heating unit to a pre-treatment temperature sufficient for organic constituents in the feedstock to decompose, for precipitates of inorganic wastes to form, for preheating the wet feedstock in preparation for subsequent removal of soluble sulfate contaminants, or combinations thereof. Processing further includes reacting the soluble sulfate contaminants with cations present in the feedstock material to yield a sulfate-containing precipitate and separating the inorganic precipitates and/or the sulfate-containing precipitates out of the wet feedstock. Having removed much of the inorganic wastes and the sulfate contaminants that can cause poisoning and fouling, the wet biomass feedstock can be exposed to the heterogeneous catalyst for gasification. |
| US08608979B2 |
Luminescent particles, methods and light emitting devices including the same
A luminescent particle includes an interior portion of the luminescent particle comprising a luminescent compound that reacts with atmospherically present components and a passivating layer on an outer surface of the luminescent particle that is operable to inhibit the reaction between the luminescent compound and the atmospherically present components. |
| US08608976B2 |
Photo alignment material and method of manufacturing display substrate using the same
A photo alignment material includes a photo alignment polymer and an organic solvent. The photo alignment polymer is prepared by polymerizing a diamine monomer including at least two photo reactive parts represented by the following Chemical Formula 1. In Chemical Formula 1, R1 represents —(CH2)n—, —O(CH2)n— or R2, R3 and R4 each independently represent —H, —O(CH2)m—1—CH3 or and n and m independently represent an integer of from 1 to 8. Thus, change of the orientation of the alignment layer due to the action of an electric stress may be prevented and/or reduced. Therefore, an after—image may be reduced, and display quality is improved. |
| US08608971B2 |
Method of manufacturing a display substrate
A method of manufacturing a display substrate includes forming a first metallic pattern including gate and storage conductors and a gate electrode of a switching device on a base substrate, forming a gate insulation layer, forming a second metallic pattern and a channel portion including a source line, source and drain electrodes of the switching device, forming a passivation layer and a photoresist film on the second metallic pattern, patterning the photoresist film to form a first pattern portion corresponding to the gate and source conductors and the switching device, and a second pattern portion formed on the storage line, etching the passivation layer and the gate insulation layer, and forming a pixel electrode using the first pattern portion. Therefore, excessive etching of the stepped portion may be prevented, so that a short-circuit defect between a metallic pattern and a pixel electrode may be prevented |
| US08608970B2 |
System and method for conditioning a hardwood pulp liquid hydrolysate
A system and method for hardwood pulp liquid hydrolysate conditioning includes a first evaporator receives a hardwood mix extract and outputting a quantity of vapor and extract. A hydrolysis unit receives the extract, hydrolyzes and outputs to a lignin separation device, which separates and recovers a quantity of lignin. A neutralization device receives extract from the lignin separation device and a neutralizing agent, producing a mixture of solid precipitate and a fifth extract. The solid precipitate is removed from the fifth extract. A second evaporator removes a quantity of acid from the fifth extract in a vapor form. This vapor may be recycled to improve total acid recovery or discarded. A desalination device receives the diluted extract, separates out some of the acid and salt and outputs a desalinated solution. |
| US08608966B2 |
Method and apparatus for dewatering a mixture of ethanol and water
The invention relates to a method and an apparatus for dewatering mixture of ethanol and water. The method comprises steps for feeding mixture of ethanol and water (1) into an evaporator (2), evaporating said mixture of ethanol and water (1) and feeding a stream of vaporized mixture of ethanol and water (3) to a vapor recompression unit (4), pressurizing vaporized mixture of ethanol and water (3) in the vapor recompression unit (4) and feeding a stream of pressurized vaporized mixture of ethanol and water (5) to a membrane unit (6), and dividing said stream of pressurized mixture of ethanol and water (5) in to a stream of mixture of ethanol and water (8) and into a stream of dewatered mixture of ethanol and water (7). |
| US08608965B2 |
Gas actuated mixing system and method
A gas bubble agitated mixing system for viscous fluids comprising: a container (1) in which a viscous fluid (2) may be held; one or more gas pipes (6), each gas pipe having an outlet (8) arranged to introduce gas bubbles (9) into the base region of the container (1), said gas bubbles (9) being of a size suitable to agitate the viscous fluid (2). The system also comprises a moveable carrier arm (4) upon which said one or more gas pipe outlets (8) are mounted; and wherein the movement of the carrier arm (4) causes the position at which each outlet (8) introduces gas bubbles (9) into the container (1) to vary over time. |
| US08608961B2 |
Method for affinity chromatography of antithrombin III
The present invention is directed to an affinity chromatography column comprising the antithrombin III (ATIII) protein bound to a solid support, characterized in that: a. the ATIII protein is the wild-type protein or a variant thereof, b. the ATIII protein has been first activated by incubation with an unmodified low-molecular-weight heparin (LMWH) rich in active species, and c. the ATIII protein is covalently bound to a resin in a ratio of less than approximately 2 mg of protein per ml of hydrated resin. The invention is also directed to the use of the aforesaid column for purifying species having an affinity for ATIII in a sample comprising species having affinity and not having affinity for ATIII. |
| US08608960B2 |
Method of purifying polypeptides by simulated moving bed chromatography
Provided are methods of separating an immunoreactive compound from at least one immaterial component, using a simulated moving bed (“SMB”) system and a SMB apparatus for use in these methods. Also provided are purified immunoreactive compounds prepared using the SMB methods and apparatus and methods of treatment with the purified immunoreactive compounds. |
| US08608959B2 |
Device for picking up objects floating on the water, such as hydrocarbons
A device for picking up floating objects on the water, such as hydrocarbons, has an envelope made of a flexible material impervious to water and to the floating objects, having a mouth at the upstream end and a discharge orifice at the downstream end, a folding rigid framework, arranged inside the envelope and attached thereto at the mouth and at the discharge orifice, at least one inflatable tube attached to the envelope and running along the length of the envelope, and a compressed-gas generation device designed to inflate the or each inflatable tube. |
| US08608958B2 |
Flowing water splitting apparatus, flowing water splitting method and sewage system
A flowing water splitting apparatus includes a first flowing water channel including a weir defining a water quantity of the flowing water flowing in from a confluent pipe and leading the flowing water flowing in from the confluent pipe to a dirty water pipe; a second flowing water channel leading flowing water flowing over the weir to a rainwater pipe; a partition wall portion provided to block the flowing water flowing through the first flowing water channel to form a plurality of water diversion chambers partitioned in the first flowing water channel; and a flow throttle portion formed in the partition wall portion to throttle a flow quantity of the flowing water flowing from one water diversion chamber into another water diversion chamber. |
| US08608957B2 |
Oil tank
An oil container has a container housing receiving an oil filter and fittings for an oil inlet, an oil outlet, for filling the oil container, and for an opening that can be closed by a cover for temporarily removing or replacing the oil filter, as well as, an air outlet opening. The container housing is divided into at least two chambers by a partition, each chamber including an oil filter. Each chamber has an oil inlet fitting, an oil outlet fitting, and an opening that can be closed by a cover for filling with oil and/or for removing the oil filter. The partition includes an oil overflow opening located above a minimum oil filling level height relative to a rest state determined for the individual oil circuits. A leak occurring in one of the oil circuits does then not affect the operational reliability of the other oil circuit(s). |
| US08608956B2 |
Curb inlet catch basin filtration apparatus
A filtration apparatus for curb vaults may be installed in existing vaults through manhole access openings whenever the smallest dimension of the access opening is greater than the smallest dimension measured across a support plate assembly of the filtration apparatus. An adjustable attachment system allows installation of the filtration apparatus by inserting the apparatus through the access opening. |
| US08608951B2 |
Process for removing metals from crude oil
A process for removing a metal from a crude oil includes contacting the crude oil containing the metal with a crude-immiscible ionic liquid to produce a crude oil and crude-immiscible ionic liquid mixture, and separating the mixture to produce a crude oil effluent having a reduced metal content relative to the crude oil feed. Optionally, a de-emulsifier is added to at least one of the contacting and separating steps. |
| US08608946B2 |
Systems, methods, and catalysts for producing a crude product
Methods and systems for contacting of a crude feed with one or more catalysts produces a total product that includes a crude product are described. The crude product is a liquid mixture at 25° C. and 0.101 MPa. One or more properties of the crude product may be changed by at least 10% relative to the respective properties of the crude feed. The produced crude product may include oxygen, sulfur, residue, or mixtures thereof. |
| US08608942B2 |
Systems and methods for residue upgrading
Systems and methods for processing hydrocarbons are provided. A hydrocarbon can be distilled to provide a distillate, a gas oil, and a residue. The residue can include, but is not limited to asphaltenes and non-asphaltenes. The residue can be mixed with a solvent to provide a mixture. The asphaltenes can be selectively separated from the mixture to provide a deasphalted oil. At least a portion of the deasphalted oil and at least a portion of the gas oil can be hydroprocessed to provide a hydroprocessed hydrocarbon. At least a portion of the distillate and at least a portion of the hydroprocessed hydrocarbon can be cracked in a first reaction zone to provide a first cracked product comprising C2 hydrocarbons, C3 hydrocarbons, C4 hydrocarbons, and naphtha. |
| US08608938B2 |
Crude product composition
The present invention is directed to a crude composition comprising hydrocarbons having a boiling range distribution of from 30° C. to 538° C., the crude composition having, per gram of crude composition, from 0.01 grams to 0.2 grams of hydrocarbon having a boiling range distribution of at most 204° C., where benzene comprises at most 0.005 grams per gram of the hydrocarbons having a boiling range distribution of at most 204° C., and from 0.000001 grams to 0.05 grams of hydrocarbons having a boiling range distribution of greater than 538° C. |
| US08608935B2 |
Apparatus and method for synthesis of alane
One embodiment of the invention includes an electrochemical cell and an externally applied electrical potential used to drive a direct synthesis reaction to produce alane. |
| US08608931B2 |
Anti-displacement hard gold compositions
Anti-displacement hard gold compositions are disclosed for inhibiting displacement of metal from substrates which are plated with the hard gold. The anti-displacement hard gold compositions may be used to spot plate substrates with hard gold. |
| US08608930B2 |
Electro-blotting devices, systems, and kits and methods for their use
The invention provides an electroblotting system for blotting gels, in which the system includes an electroblotting transfer stack that comprises an analysis gel and a blotting membrane, an anode, an ion source juxtaposed with the anode between the anode and the transfer stack, a cathode, and another ion source juxtaposed with the cathode between the cathode and the transfer stack, in which the each ion source is sufficient for electrophoretic transfer. The anode, the cathode, or both can be separate from a power supply and provided as part of a disposable electrode assembly that also includes a body of gel matrix that includes ions for electrophoretic transfer. |
| US08608926B2 |
Amperometric in-pipe electrochemical sensing probe
A sensing probe intended to measure the content of an oxygen reducible substance in a fluid, includes: a probe body containing an interface and processing circuit, a dry sensing head including an amperometric sensor intended to measure the content of the oxygen reducible substance. The sensing head is removable. The sensing head and the probe body include respectively coupling elements cooperating with each other and able to be separated, and the sensing probe furthermore includes connecting elements designed to connect the removable sensing head to the interface and processing circuit of the probe body. |
| US08608921B2 |
Layered enzyme compositions for use with analyte sensors
Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes. |
| US08608920B2 |
Electrochemical biosensor strip and method for identifying a corresponding biosensing device by said strip
The present invention relates to an electrochemical biosensor strip comprising a base which has a front side and a back side, an electrode system on the front side of said base, a code-recognition element on one end of the back side of said base, a cover which is located on said electrode system, and a reaction area which is in touch with said electrode system for a reaction to take place. By forms of said code-recognition element provided in the present invention, a biosensing device will automatically choose a specific set of calibration code corresponding to a particular batch of the electrochemical biosensor strip while coupling to the strip. Hence, the present invention eliminates the calibration step carried out by users and simplifies the measuring procedure, avoiding the inaccurate results due to the omission or improper operation of the calibration step by users. The present invention further relates to a method for identifying a corresponding biosensing device by using a ratio of lengths of each length-changeable area of the strip. |
| US08608910B2 |
Coal reforming apparatus
A coal reforming apparatus includes: a dryer body provided to dry low-quality coal; a pyrolysis body which pyrolyzes the dried coal thus dried; and a briquetter which compression-molds the pyrolyzed coal thus pyrolyzed. The coal reforming apparatus has a radical scavenger supplier which supplies drying gas with a radical scavenger so that the low-quality coal can be dried in an atmosphere containing the radical scavenger, the drying gas being supplied from a drying gas supply source and heated by a heater, the radical scavenger being formed of an organic compound having a hydroxyl group. |
| US08608909B2 |
Advanced dewatering system
A permeable belt for use in a system for dewatering and/or drying a fibrous web. The permeable belt capable of being subjected to a tension of at least approximately 30 kN/m, the permeable belt having at least one side having an open area of at least approximately 25% and a contact area of at least approximately 10%. |
| US08608908B2 |
Method and system using low fatty acid starches in paper sizing composition to inhibit deposition of multivalent fatty acid salts
A method for inhibiting deposition of multivalent saturated fatty acids on paper sizing equipment and/or devices which use a paper surface sizing composition containing higher starch solids levels of surface sizing starches and a source of multivalent cations, such as a multivalent metal drying salt, by including (wholly or partially) one or more low fatty acid surface sizing starches in the paper surface sizing composition. Also, a paper surface sizing system for carrying out this method. |
| US08608907B2 |
Fluorescent whitening agent compositions
A composition suitable for paper brightening, wherein the composition contains one or more specified fluorescent whitening agents with taurine groups. The composition is used for whitening paper, in particular at the wet-end, in the size press or by coating. |
| US08608902B2 |
Plasma processing apparatus
A vertical plasma processing apparatus for performing a plasma process on a plurality of target objects together at a time includes an activation mechanism configured to turn a process gas into plasma. The activation mechanism includes a vertically elongated plasma generation box attached to a process container at a position corresponding to a process field and confining a plasma generation area airtightly communicating with the process field, an ICP electrode disposed outside the plasma generation box and extending in a longitudinal direction of the plasma generation box, and an RF power supply connected to the ICP electrode. The ICP electrode includes a separated portion separated from a wall surface of the plasma generation box by a predetermined distance. |
| US08608898B2 |
Multilaminar wood veneer block, multilaminar wood veneers and method for the manufacture thereof
Multilaminar wood block from which to obtain multilaminar wood veneers by means of a slicing operation comprising a plurality of superimposed wood veneers (2), and a plurality of layers (3) of adhesive alternating with the veneers (2) to stably connect a veneer (2) with an adjacent veneer (2). The layer (3) of adhesive is formed from a glue free from formaldehyde. |
| US08608896B2 |
Liquid adhesive lamination for precision adhesive control
Methods for liquid adhesive lamination for precision adhesive control are provided. Precision liquid adhesive control can be obtained by first patterning liquid adhesive in a thin pre-coat layer on a substrate. A second adhesive layer can then be patterned on top of the pre-coat layer. When the second substrate is pressed onto the first substrate, the second substrate first comes into contact with the second adhesive layer. The adhesive can then be spread uniformly across the two substrates without forming voids. Alternatively, a single liquid adhesive layer can be formed in a three dimensional gradient pattern. |
| US08608892B2 |
Method for making a color display device
A method of making a color display device and color display device are provided for the display of metallic or special effect pigmented paint using commercially available or the manufacturer's paint. In the method provided herein, the metallic or special effect pigmented paint is sprayed onto a web behind a knife or onto a first roller which is a part of a roller roller coater. |
| US08608890B2 |
Reconfigurable shape memory polymer tooling supports
A method and support apparatus for providing structural support to a mold or mandrel, such as a shape memory polymer (SMP) apparatus configured for shaping a composite part. The support apparatus may comprise a rigid structural member and a plurality of SMP cells attached thereto and configured to inflate or deploy in a malleable state toward and against a surface of the SMP apparatus, mold, or mandrel. Then the SMP cells may be returned to a rigid state while still pressed against this surface, thereby providing structural support when composite material is applied to an opposite surface of the SMP apparatus, mold, or mandrel. After the composite material is cured into the finished composite part, the SMP cells may be deflated or otherwise collapse toward the structural member to provide enough clearance to be removed from the cured composite part. |
| US08608889B2 |
Method for handling adhesive laminate sections
A method of handling an adhesive laminate, wherein the adhesive laminate is provided releasably adhered to a first web, comprising a plurality of cut or punched sections and wherein adjacent sections of the adhesive laminate remain joined to one another in the longitudinal direction of the web through one or more tie points. A first supporting structure and a second supporting structure adjacent to the first supporting structure are provided. The first web is led over the first supporting structure. A second web is provided and led over the second supporting structure, wherein the second web is oriented such that the release surface of the second web faces the first supporting structure. A leading portion of a first section of adhesive laminate from the first web is attached to the release surface of the second web and the second web is advanced such that the first section of the adhesive laminate is detached from a second section of adhesive laminate and the leading edge of the second section of adhesive laminate is adhered to the second web in a spaced apart configuration from the trailing edge of the first section of the adhesive laminate. A transdermal drug delivery device prepared by such a method. |
| US08608887B1 |
Slip-on corner protectors for picture frames and machine and method of making same
A slip-on corner protector for rectangular picture frames includes a flat cardboard pre-form which is bent into the shape of a hollow prism having right triangularly-shaped front and rear frame face cover panels joined at vertical and horizontal sides thereof by a vertical and horizontal rectangularly-shaped frame edge cover panel, respectively. Triangularly-shaped spring flaps bent inwardly from hypotenuse edges of the front and rear triangular panels are pressed against and thus grip a frame inserted between the front and rear triangular panels because of the elasticity of the cardboard pre-form. A machine and method for manufacturing corner protectors from a stack of pred-forms bends panels perpendicularly upwards from a pre-form by linear actuators, spays a hot melt adhesive blob onto an upright panel, and presses it against another upright panel to form an adhesive bond. |
| US08608886B2 |
Method for connecting a first component to a second component
A method for connecting a first component to a second component, the method including: applying a fastening dome composed of material in a viscous state to the first component, hardening the fastening dome on the first component, and then inserting a connecting element through the first component, second component, and at least partially through the fastening dome. |
| US08608885B2 |
Substrate heat treatment apparatus
A substrate heat treatment apparatus includes a heat-treating plate having a flat upper surface, support devices formed of a heat-resistant resin for contacting and supporting a substrate, a seal device disposed annularly for rendering gastight a space formed between the substrate and heat-treating plate, and exhaust bores for exhausting gas from the space. The support devices are formed of resin, and the upper surface of the heat-treating plate is made flat, whereby a reduced difference in the rate of heat transfer occurs between contact parts and non-contact parts on the surface of the substrate. Consequently, the substrate is heat-treated effectively while suppressing variations in heat history over the surface of the substrate. |
| US08608883B2 |
Adherent layer
The present disclosure describes embodiments of an adherent layer that may be used to attach a geo-membrane to a concrete slab and methods that include installation of the adherent layer. The adherent layer can be used to inhibit the geo-membrane from becoming disengaged with the concrete slab and can thereby help prevent water from penetrating the geo-membrane and causing moisture damage to the structure above. |
| US08608881B2 |
Method of forming a breast prosthesis
A breast prosthesis is formed by providing a core of low density foam, shaping the core in the general form of a breast, and applying an outer layer of resilient skin to an outer side of the core to substantially resemble a breast. The inner side of the core opposite the outer side is shaped for mating engagement with a user. A plurality of interchangeable covers of flexible material are each arranged to releasably span the inner side of the core. Typically, coloring is provided on the outer side to resemble an areola of the breast and a protrusion arranged to resemble a nipple of the breast is releasably adhered to the outer side at various positions relative to the areola. |
| US08608879B1 |
Environmentally friendly flare illuminant composition
The present invention is a flare illuminant composition, useful in hand-held signals, which composition is environmentally friendly and economical, containing a commercially available, aromatic, high energy, amine-based organic compound, 5-aminotetrazole, in place of the conventional and toxic KClO4, or, for the known alternative to KClO4, expensive, strontium bis-(1-methyl-5-nitriminotetrazolate)monohydrate. |
| US08608876B2 |
AA7000-series aluminum alloy products and a method of manufacturing thereof
An AA7000-series alloy including 3 to 10% Zn, 1 to 3% Mg, at most 2.5% Cu, Fe<0.25%, and Si<0.12%. Also, a method of manufacturing aluminum wrought products in relatively thick gauges, i.e. about 30 to 300 mm thick. While typically practiced on rolled plate product forms, this method may also find use with manufacturing extrusions or forged product shapes. Representative structural component parts made from the alloy product include integral spar members, and the like, which are machined from thick wrought sections, including rolled plate. |
| US08608875B1 |
Sponge-iron alloying
A steel manufacturing process can include forming an iron oxide layer on a hot band during hot rolling; reducing the iron oxide layer on the hot band to form a sponge iron layer that includes pores; the sponge-iron layer having a thickness in a range of about 0.05 μm to about 1000 μm, about 0.1 μm to about 100 μm, or about 5 μm to about 25 μm; and depositing an alloying element into the pores of the sponge iron layer to form an impregnated sponge-iron layer. The process can further include annealing the impregnated sponge-iron layer to produce an iron alloy layer carried by the substrate. |
| US08608874B2 |
Spring steel and method for manufacturing the same
Disclosed is high strength spring steel that can limit the depth of pitting occurring when corroded and therefore possesses high strength as well as excellent pitting corrosion resistance and corrosion fatigue property, with a composition containing: C: greater than 0.35 mass % and less than 0.50 mass %; Si: greater than L75 mass % and less than or equal to 3.00 mass %; Mn: 0.2 mass % to 1.0 mass %; Cr: 0.01 mass % to 0.04 mass %; P: 0.025 mass % or less; S: 0.025 mass % or less; Mo: 0.1 mass % to 1.0 mass %; and 0: 0.0015 mass % or less, under a condition that a PC value calculated by PC=4.2×([C]+[Mn])+0.1×(1/[Si]+1/[Mo])+20.3×[Cr]+0.001×(1/[N]) is greater than 3.3 and equal to or less than 8.0. Also disclosed is a preferred method for manufacturing the same. |
| US08608872B2 |
High-strength stainless steel pipe excellent in sulfide stress cracking resistance and high-temperature carbonic-acid gas corrosion resistance
The problem to be solved is the provision of a high-strength stainless steel pipe having a sufficient corrosion resistance in a high-temperature carbonic acid gas environment and having an excellent sulfide stress cracking resistance at normal temperature. A high-strength stainless steel pipe consist of, by mass %, C: 0.05% or less, Si: 1.0% or less, P: 0.05% or less, S: less than 0.002%, Cr: more than 16% and 18% or less, Mo: more than 2% and 3% or less, Cu: 1% to 3.5%, Ni: 3% or more and less than 5%, Al: 0.001% to 0.1% and O: 0.01% or less, Mn: 1% or less and N: 0.05% or less, and Mn and N in the above ranges satisfy formula (1), and the balance being Fe and impurities; and the metal micro-structure of the stainless steel pipe mainly includes a martensitic phase and comprises 10 to 40% of a ferritic phase by volume fraction and 10% or less of a retained γ-phase by volume fraction. [Mn]×([N]−0.0045)≦0.001 (1) wherein the symbols of elements in formula (1) respectively represent the contents (unit: mass %) of the elements in the steel. |
| US08608870B2 |
Carburization heat treatment method and method of use
Disclosed is a carburization heat treatment method including carburizing a workpiece at a relatively low temperature within a temperature range of A1˜A3 using a vacuum carburizing furnace and then performing quenching using a high-pressure gas, in which the workpiece is made of typical carburizing alloy steel having a carbon content of about 0.10˜0.35 wt %. This method can be applied to carburization heat treatment of a steel workpiece sensitive to heat deformation, such as an annulus gear, in lieu of a conventional gas carburization method using plug quenching. |
| US08608867B2 |
Individualized jewelery alloys and method for their production
A method for the individualization of a metallic material by means of a carbon-containing basic material of organic origin is proposed. The novel method makes it possible to produce individualized ornamental alloys and individualized symbolic articles, such as pieces of jewelry, in a first step a carbon-containing organic basic material, which originates from at least one specific clearly identifiable person or a clearly identifiable group of persons, being converted into a carbonized initial material, and, in a second step, a physical and chemical incorporation of at least a fraction of the carbonized initial material into the metallic material taking place. The novel method and the novel ornamental alloys make it possible to produce symbolic articles with a direct material or substantive relation to a desired person by simple means, without creative freedom being restricted. |
| US08608866B2 |
Detergent dispenser for improved detergent removal
Embodiments of the present invention are related to a detergent dispenser configured to attach to an interior surface of a dishwasher door. The detergent dispenser may comprise a reservoir configured to hold detergent, wherein a portion of the upper wall of the reservoir has been removed to reduce a cross-sectional length thereof such that water flowing down the dishwasher door is encouraged into the reservoir. The detergent dispenser may also comprise a dispenser door comprising a closed configuration and an open configuration, wherein the dispenser door is configured to cover the reservoir in the closed configuration. The detergent dispenser may be configured to encourage water flowing down the interior surface of the dishwasher door to enter the reservoir when the dispenser door is in the open or closed configuration. |
| US08608864B2 |
Substrate treating method
A substrate treating method for treating substrates with a treating liquid includes a deionized water cleaning step for supplying deionized water from an injection pipe and cleaning the substrates inside a cleaning tank with deionized water, then a replacing step for injecting a solvent from a solvent injector and replacing the deionized water with the solvent, a separating and removing step for switching a channel to a branch pipe and causing a separator to remove the deionized water from the treating liquid, and an adsorbing and removing step for switching the channel to another branch pipe and causing a deionized water remover to adsorb and remove the deionized water from the treating liquid. |
| US08608862B2 |
Clean in place gassing manifold
A method for cleaning a gassing manifold includes providing a gassing module and a complementary clean in place module for coupling to the gassing module. Cleaning solution is pumped from the clean in place module to the gassing module above a minimum flow rate and velocity for effective cleaning. |
| US08608860B2 |
Adhesive compositions capable of completely removing acari, bacteria, moths, ticks, fleas from fabrics and animal's hair
A method for removing microorganisms and small insects from fabric or animal's hair comprising applying and removing an adhesive composition comprising at least one adhesive polymer and a plasticizer, wherein the amounts of this plasticizer range from about 5 to about 45% by weight of the total weight of the wet adhesive composition.The adhesive composition used in the method of the invention thanks to the presence of high plasticizer concentrations are very fluid to allow said micro-organisms or small insects to be removed and, at the same time, they leave no residue on the fabric, or animal's hair.The present invention further relates to adhesive compositions to be used in the method of the invention further containing active ingredients which are released from the adhesive composition during the step of removing the organisms from the fabric or the animal's hair. |
| US08608858B2 |
Substrate cleaning apparatus and method for determining timing of replacement of cleaning member
A substrate cleaning apparatus includes a cleaning apparatus 10 including an abutting member which is to be pressed against a cleaning member to clean the cleaning member, a drive control device for controllably driving the abutting member, and a cleaning tank which contains a cleaning liquid and allows a portion of abutment between the cleaning member and the abutting member to be impregnated with the cleaning liquid. The substrate cleaning apparatus also includes an image capturing device which captures a surface image of the cleaning member and an image processing device. A surface condition of the cleaning member is monitored to determine the timing of replacement of the cleaning member. The substrate cleaning apparatus further includes a measurement device which measures the number of particles and/or a concentration of a component in the cleaning liquid in the cleaning tank. Results of measurement by the measurement device are fed back to a drive control device, to thereby prevent contamination of the cleaning member. |
| US08608853B2 |
Thermal reactor with improved gas flow distribution
Embodiments of the present invention provide apparatus and method for improving gas distribution during thermal processing. One embodiment of the present invention provides an apparatus for processing a substrate comprising a chamber body defining a processing volume, a substrate support disposed in the processing volume, wherein the substrate support is configured to support and rotate the substrate, a gas inlet assembly coupled to an inlet of the chamber body and configured to provide a first gas flow to the processing volume, and an exhaust assembly coupled to an outlet of the chamber body, wherein the gas inlet assembly and the exhaust assembly are disposed on opposite sides of the chamber body, and the exhaust assembly defines an exhaust volume configured to extend the processing volume. |
| US08608851B2 |
Plasma confinement apparatus, and method for confining a plasma
A plasma confinement apparatus, and method for confining a plasma are described and which includes, in one form of the invention, a plurality of electrically insulated components which are disposed in predetermined spaced relation, one relative to the others, and surrounding a processing region of a plasma processing apparatus, and wherein a plurality of passageways are defined between the respective insulated components; and at least one electrically conductive and grounded component forms an electrical field shielding for the processing region. |
| US08608850B1 |
Low-energy, hydrogen-free method of diamond synthesis
Diamond thin films were deposited on copper substrate by the Vapor Solid (VS) deposition method using a mixture of fullerene C60 and graphite as the source material. The deposition took place only when the substrate was kept in a narrow temperature range of approximately 550-650° C. Temperatures below and above this range results in the deposition of fullerenes and other carbon compounds, respectively. |
| US08608849B2 |
Method for making zinc oxide nano-structrure
A method for making zinc oxide nano-structure, the method includes the following steps. Firstly, providing a growing device, the growing device comprising a heating apparatus and a reacting room. Secondly, providing a growing substrate and forming a metal layer thereon. Thirdly, depositing a catalyst layer on the metal layer. Fourthly, placing the growing substrate into the reacting room together with a quantity of zinc source material. Fifthly, introducing a oxygen-containing gas into the reacting room. Lastly, heating the reacting room to a temperature range of 500˜1100° C. |
| US08608846B2 |
Liquid silicone rubber coating composition, curtain airbag, and its production method
A liquid silicone rubber coating composition exhibiting high adhesion for an airbag base fabric; a curtain airbag having a silicone rubber coating layer of the cured composition formed on at least one surface of the base fabric; and a method for producing such curtain airbag are provided. The composition comprises (A) an organopolysiloxane having at least 2 alkenyl groups bonded to the silicon atoms per molecule; (B) an organohydrogenpolysiloxane having at least 2 structural units represented by formula (1) per molecule, the structural units being linked by a non-siloxane structural unit not containing SiH group; (C) an addition catalyst; (E) an organosilicon compound having an epoxy group and an alkoxy group bonded to the silicon atom in the molecule; and (F) a titanium compound and/or a zirconium compound; and preferably (D) a fine powder silica having a specific surface area of at least 50 m2/g. |
| US08608845B2 |
Cutback asphalt compositions and products comprising an extender derived from tall oil, and methods for making and using same
Cut back asphalt compositions and product wherein the cutting solvent comprises a tall oil based solvent and optionally other renewable solvents. |
| US08608840B2 |
Choke assembly
A choke assembly comprises an inlet (48) for a multiphase fluid stream, the stream comprising a first relatively heavy fluid phase and a second relatively light fluid phase; a first fluid outlet (116); a choke element (22) disposed between the inlet and the first fluid outlet operable to control the flow of fluid between the inlet and the first fluid outlet; a separation chamber (40, 114) disposed to provide separation of phases in the fluid stream upstream of the choke element; and a second outlet (118) for removing fluid from the separation cavity. The choke assembly is of particular use in the control of fluid streams produced from a subterranean well, in particular oil and gas produced from a subsea well. |
| US08608838B2 |
Tubing air purification system
The invention provides an air purification system in form of tubing, by which particulates of various sizes in the air flow can be collected. The system includes an air inlet, an air outlet and a particulate removing unit located therebetween, the particulate removing unit including a tubing array of material having low dielectric constant, when an air flow passes through the system electrostatic effect is created between the air flow and the tubing material so as to remove the particulates entrained within the air flow. The invention also provides a method for removing particulates from air flow using the electrostatic effect created between the air flow and said material. |
| US08608836B2 |
Integral hydrogen and air purifier
A gas purifier assembly for providing first (50) and second (38) purified gas streams having an integral heater (54). The assembly can have two separate chambers for gaseous fluid flow for the purpose of purifying a gas stream of hydrogen (34), for example, and a separate distinct stream of gas such as compressed air (46). A centrally located heater heats the first chamber to effect purification of the first gas. Waste heat from the first chamber is transferred to the second chamber via conduction to effect purification of the second gas stream. |
| US08608835B2 |
Exhaust gas purification system for an internal combustion engine
An exhaust gas purification system for an internal combustion engine of a motor vehicle is provided. The system includes a first particulate filter element and a second particulate filter element, which is connected downstream of the first particulate filter element and through which flows the exhaust gas that emanates from the first particulate filter element. The first particulate filter element operates as a system filter and the second particulate filter element operates as a diagnostic filter. A charge of the diagnostic filter can be determined, and the functional capability of the system filter can be deduced based thereon. |
| US08608832B2 |
Apparatus for concentrating and diluting specific gas and method for concentrating and diluting specific gas
One ozone concentrating chamber is provided therein with a part of a cooling temperature range where ozone can be selectively condensed or an oxygen gas can be selectively removed by transmission from an ozonized oxygen gas, and a part of a temperature range where condensed ozone can be vaporized, and condensed ozone is vaporized by moving condensed ozone with flow of a fluid or by gravitation to the part where condensed ozone can be vaporized, whereby the ozonized oxygen gas can be increased in concentration. Such a constitution is provided that a particle material 13 for condensation and vaporization filled in the ozone concentrating chambers 11 and 12 has a spherical shape of a special shape with multifaceted planes on side surfaces, or an oxygen transmission membrane 130 capable of selectively transmitting an oxygen gas in an ozone gas is provided. |
| US08608826B2 |
Method of modeling fly ash collection efficiency in wire-duct electrostatic precipitators
The method of modeling fly ash collection efficiency in wire-duct electrostatic precipitators provides for the optimization of fly ash collection through the generation of numerical solutions to the electrostatic and electrodynamic equations associated with the particular geometry of the wire-duct electrostatic precipitator. Particularly, the solutions are developed through use of the finite element method and a modified method of characteristics. |
| US08608824B2 |
Integrated method for producing carbonyl iron powder and hydrocarbons
Integrated process, in which pure carbonyl iron powder (CIP) is prepared by decomposition of pure iron pentacarbonyl (IPC) in a plant A, carbon monoxide (CO) liberated in the decomposition of the IPC is used in plant A for the preparation of further CIP from iron or is fed to an associated plant B for the preparation of synthesis gas or is fed to an associated plant C for the preparation of hydrocarbons from synthesis gas, and the CIP prepared in plant A is used as catalyst or catalyst component in an associated plant C for the preparation of hydrocarbons from synthesis gas from plant B. |
| US08608821B2 |
Method for the production of fertilizer and CO2
The invention provides a method for the combined production of (i) a fertilizer selected from the group consisting of ammonium nitrate, ammonium phosphates or a combination thereof, (ii) a concentrated stream of CO2 through an indirect neutralization of ammonia with an acid selected from the group consisting of nitric acid, phosphoric acid, a salt thereof and a combination thereof; said method comprising: (I) reacting a carbonate product with a reagent selected from the group consisting of nitric acid, phosphoric acid, a salt thereof, and a mixture thereof to form CO2, and a fertilizer containing an ammonia component; and (II) separating at least a portion of said carbon dioxide from said fertilizer in a condensed and relatively concentrated stream. |
| US08608820B2 |
Filter for filtering particulate matter from exhaust gas emitted from a compression ignition engine
A filter for filtering particulate matter (PM) from exhaust gas emitted from a compression ignition engine, which filter comprising a porous substrate having inlet surfaces and outlet surfaces, wherein the inlet surfaces are separated from the outlet surfaces by a porous structure containing pores of a first mean pore size, wherein the porous substrate is coated with a wash coat comprising a plurality of solid particles comprising a molecular sieve promoted with at least one metal wherein the porous structure of the wash coated porous substrate contains pores of a second mean pore size, and wherein the second mean pore size is less than the first mean pore size. |
| US08608818B2 |
Filter element having sealing members and methods
A filter arrangement includes a media construction comprising a corrugated sheet secured to a flat sheet rolled into a coiled construction. A frame and a first seal member are provided. The frame secures the first seal member to the coiled construction. The first seal member is preferably oriented to form a radial seal with a housing. A second seal member is secured to the outer annular surface of the coiled construction. The second seal member includes a gasket extension having first and second opposite ends; an attachment portion; and a protrusion extending from the attachment portion. The second seal member is preferably oriented to form an axial seal with a housing. Air cleaners preferably utilizing filter arrangements as described herein operably installed within housings. Methods of installing, filtering, assembling, and servicing preferably include arrangements as described herein. |
| US08608816B2 |
Fluid filtration device and system
A medical fluid filter system is provided having a housing having: a liquid trap chamber having a volume; a filter media chamber; a filter media arranged within the filter media chamber; the liquid trap chamber having a liquid trap outlet port in fluid communication with the filter media chamber; the liquid trap outlet port configured and arranged within the liquid trap chamber to inhibit flow of liquid from the liquid trap chamber to the filter media chamber and configured and arranged to allow gas to flow from the liquid trap chamber to the filter media chamber; a filter system inlet passing through the housing for intake of fluid originating from a surgical site; and a filter system outlet passing through the housing for fluid exhaust. |
| US08608815B2 |
Methods of fabricating polycrystalline diamond compacts
Embodiments relate to methods of manufacturing polycrystalline diamond compacts (“PDCs”). In an embodiment, a method of fabricating a PDC includes positioning a plurality of diamond particles adjacent to a cemented carbide material. The cemented carbide material includes one or more types of tungsten-containing eta phases. The method further includes subjecting the plurality of diamond particles and the cemented carbide material to a high-pressure/high-temperature process effective to sinter the plurality of diamond particles so that a polycrystalline diamond table is formed without tungsten carbide grains of the cemented carbide material exhibiting abnormal grain growth that project into the polycrystalline diamond table. |
| US08608814B2 |
Systems and methods for reliable feedstock delivery at variable delivery rates
Hydrogen-producing fuel processing assemblies and methods for delivering feedstock to a hydrogen-producing region of a hydrogen-producing fuel processing assembly. In some embodiments, the fuel processing assemblies include a feedstock delivery system that includes a pump assembly and a stall prevention mechanism that is adapted to reduce pressure in an outlet conduit during periods in which the pump assembly is not emitting a liquid outlet stream within or above a hydrogen-producing pressure range. In some embodiments, pressure in the outlet conduit is isolated from pressure in the hydrogen-producing region of the fuel processing assembly and is reduced during periods in which a liquid stream is not being pumped within or above a hydrogen-producing pressure range. |
| US08608813B2 |
Method of manufacturing solid fuel mainly including synthetic resin-pulp scrap
Disclosed are eco-friendly and low-price solid fuel, which is naturally dried, and a method of manufacturing the same. Disposable diapers or disposable sanitary pads, which are failed during the manufacturing process, are used to produce industrial alternative fuel having a low price through a predetermined process, so solid fuel having no pollution problem in combustion is provided. The solid fuel is mainly made of synthetic resin-pulp scrap including synthetic resin integrated with pulp like the disposable diapers or the disposable sanitary pads. The method includes introducing a scrap, such as the wasted disposable diaper or the wasted disposable sanitary pad, including synthetic resin integrated with pulp into a crusher to break the scrap into fragments, adding a slight amount of waste cooking oil serving as a binding agent to the fragments, performing an extrusion-molding with respect to the fragments, cutting the extrusion-molded fragments to make pallets, and then drying pallets. |
| US08608811B2 |
Composition and process for oxidative colouring keratin fibers
The present invention relates to a process for oxidative coloring keratin fibers especially human hair wherein dyeing composition comprises a cross linked copolymer. The objective of the present invention is a process for oxidative coloring hair wherein compositions A and B are mixed, composition A comprises at least one oxidative dye precursor and optionally at least one coupling agent and optionally at least one direct dye in a cosmetically acceptable medium and composition B comprises at least one oxidizing agent in a cosmetically acceptable medium, and applied onto hair and processed for 1 to 45 min at a temperature range of 20 to 45° C. and rinsed off from hair, wherein at least one of the two compositions A and B comprises a cross linked copolymer of vinylpyrrolidone, vinylimidazol, 3-methyl-1-vinylimidazolium and methacrylic acid. |
| US08608810B2 |
Hair colorant compositions comprising 3-amino-2,6-dimethylphenol and 1,4-phenylenediamine-type developers, methods, and kits comprising the compositions
A hair colorant composition comprises 3-amino-2,6-dimethylphenol in combination with a second dye coupler selected from the group consisting of 2,6-dihydroxyethylaminotoluene, 2,6-diaminopyridine and a developer selected from the group consisting of 2-methyl-1,4-benzenediamine, 2-methyl-1,4-benzenediamine sulfate salt, p-phenylenediamine, p-toluenediamine, hydroxyethyl-p-phenylenediamine, N,N-bis(hydroxyethyl)-p-phenylenediamine, 2-methoxymethyl-1,4-benzenediamine. A kit for coloring hair comprises the hair colorant composition. A method of treating hair comprises applying the hair colorant composition to hair. |
| US08608803B2 |
Implant derived from bone
An implant which is particularly suitable for the repair and/or replacement of a skeletal joint, e.g., a vertebral joint, includes a unit of monolithic bone possessing at least one demineralized region exhibiting properties of flexibility and resilience, the demineralized region having diminished or insignificant capacity for promoting new bone growth. |
| US08608802B2 |
Implantable devices for subchondral treatment of joint pain
Devices and associated methods are disclosed for treating bone, and particularly bone tissue at the joints. Disclosed are implantable devices that can be used either alone or in combination with this augmentation or hardening material for the repair of bone defects and which are particularly suited for use at the joints, and even more particularly, suited for use at the subchondral bone level. |
| US08608801B2 |
Osteochondral implants, arthroplasty methods, devices, and systems
Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided. |
| US08608800B2 |
Switchable diffractive accommodating lens
A lens in accordance with the present invention includes an accommodating cell having two chambers with at least one chamber filled with optical fluid with the refractive index matching the refractive index of the accommodating element separating them. The accommodating element has a diffractive surface with surface relief structure that maintains its period but changes its height due a pressure difference between the chambers to redirect most of light that passes through the lens between different foci of far and near vision. The invention also includes a sensor cell that directly interacts with the ciliary muscle contraction and relaxation to create changes in pressure between the accommodating cell chambers that results in changing surface relief structure height and the lens accommodation. |
| US08608799B2 |
Umbrella-shaped accommodating artificial ocular lens (AAOL) device
An accommodating artificial ocular lens (AAOL) device including a lens optic portion connected to a pleated lens haptic portion to provide accommodation of vision of the eye. |
| US08608797B2 |
Mitral valve treatment techniques
Apparatus (20) is provided for treating mitral valve regurgitation, including a band (30) having distal and proximal ends, the band (30) adapted to be placed: around between 90 and 270 degrees of a mitral valve (58), including around at least a portion of a posterior cusp (56) of the valve (58), in a space defined by (a) a ventricular wall (70), (b) a ventricular surface of the posterior cusp (56) in a vicinity of an annulus (60) of the mitral valve (58), and (c) a plurality of third-order chordae tendineae (74). The apparatus (20) further includes distal and proximal coupling elements (32, 34), coupled to the band (30) at the distal and proximal ends thereof, respectively, and adapted to be coupled to a first chorda tendinea and a second chorda tendinea, respectively, each of the first and second chordae tendineae selected from the group consisting of: one of the plurality of third-order chordae tendineae (74), and a first-order chorda tendinea that inserts on a commissural cusp (78) of the mitral valve (58). Additional embodiments are also described. |
| US08608794B2 |
Flexible stent with improved axial strength
A stent comprises a generally cylindrical band having a pattern of alternating first and second struts, the first struts being wider than the second struts, the first and second struts being of substantially the same length. |
| US08608793B2 |
Energized stents and methods of using the same
The present disclosure relates to surgical systems including energized/energizable stents, and methods of using the same in the prevention of restenosis. A surgical system for treating a stenosis and/or a restenosis site s provided. The surgical system includes an electrosurgical generator; an energy transmitting conduit connectable to the electrosurgical generator; and a stent positionable in a body lumen at a site of a stenosis. The stent is fabricated from an electrically conductive material and adapted to electrically communicate with the electrosurgical generator, and the energy transmitting conduit delivers electrosurgical energy to the site of the stenosis. |
| US08608790B2 |
Bifurcation catheter and method
A catheter assembly for treatment of a vessel bifurcation. The catheter assembly is adapted for use with a single guidewire, wherein the guidewire is used to both position the catheter assembly within a main vessel of the vessel bifurcated and then be advanced into a branch vessel of the vessel bifurcated. A guidewire lumen of the catheter assembly is defined by a portion of a catheter shaft of the catheter assembly and a portion of a side catheter branch of the catheter assembly. The side catheter branch extends from a distal end of the catheter shaft at a proximal location and is connected at a distal location to a main catheter branch. After the catheter assembly has been advanced over the guidewire to a position within the main vessel at the vessel bifurcation, the guidewire is retracted, a portion of the side catheter branch is advanced into the branch vessel, and the guidewire is advanced into the branch vessel. |
| US08608786B2 |
Apparatus for delivering multiple forms of electromagnetic radiation and method for its use
An apparatus for delivering multiple forms of electromagnetic radiation and methods for its use are disclosed. An example embodiment may comprise a radiation unit having one or more light emitting diodes that emit electromagnetic radiation in continuous wave form and one or more laser diodes that emit electromagnetic radiation in continuous wave form. The radiation unit may be connected to a frequency generator that provides a waveform. The waveform may convert the continuous wave output of the laser diodes to pulse wave output, while leaving the continuous wave output of the light emitting diodes unaffected. The frequency generator may cause the emission of an additional electromagnetic field proximate the radiation unit. Associated apparatuses and methods for their use are also provided. |
| US08608785B2 |
Hammer toe implant with expansion portion for retrograde approach
An implant for fusing adjacent bones is disclosed. The implant includes an elongate threaded member and a flexible portion extending from the elongate threaded member. The flexible portion includes a plurality of prongs configured to be reversibly compressed toward an axis defined by the elongate threaded member. |
| US08608783B2 |
Bone plate with flange member and methods of use thereof
Aspects of the present disclosure include a bone plate and/or a bone plate system. The bone plate includes an elongate body, which elongate body includes a top and a bottom surface as well as a distal portion, a proximal portion, and an intercalating portion disposed between the distal and proximal portions. The elongate body also includes a flange member, which flange member is configured for contacting a bone portion, e.g., a fractured bone portion, so as to aid in the stabilization and correct anatomical reduction thereof. |
| US08608778B2 |
Intervertebral stabilization system
An intervertebral stabilization system for at least three vertebraecomprising pedicle screws attachable to the vertebrae; at least one rod for the connection of at least two pedicle screws to form a rigid stiffening system; and at least one band which is capable of being pre-stressed in tension and which is surrounded in the implanted state of the stabilization system by at least one compressible pressure member arranged between two adjacent pedicle screws for the connection of the pedicle screws to form an elastic support system, wherein a common pedicle screw is associated both with the stiffening system and with the support system and the band is can be connected or is connected to the rod by means of a band attachment. |
| US08608777B2 |
Method and apparatus for coupling soft tissue to a bone
A method for coupling soft tissue to bone including: positioning a first anchor in a first bone bore, the first anchor having a first self-locking adjustable suture construct including a first adjustable loop, a second adjustable loop, and a pair of first ends; positioning a second anchor in a second bone bore, the second anchor having a second self-locking adjustable suture construct including a third adjustable loop, a fourth adjustable loop, and a second end; positioning the first adjustable loop relative to the soft tissue; positioning the second adjustable loop about the third adjustable loop; and tensioning the pair of first ends and the second end to pull the first adjustable loop against the soft tissue, couple the second adjustable loop to the third adjustable loop, pull the second adjustable loop against the soft tissue, and pull the third adjustable loop against the soft tissue. |
| US08608776B2 |
Reduced-pressure, abdominal treatment systems and methods
A reduced-pressure abdominal treatment system has an open-cavity treatment device for providing reduced-pressure treatment proximate a patient's abdominal contents; a deep-tissue closure device for applying a closing force on a deep-tissue wound on a patient's fascia; a surface-wound closure subsystem for providing a closing force on a surface wound on the patient's epidermis; and a reduced-pressure supply subsystem operable to develop a reduced pressure. Methods are also included. |
| US08608775B2 |
Two part tape adhesive for wound closure
A wound closure device includes a first applicator including a handle portion and a substrate engaging portion and a second applicator including a handle portion and a substrate engaging portion. A first substrate is releasably couplable to the substrate engaging portion of the first applicator and includes a tissue reactive surface and a self-reactive surface. A second substrate is releasably couplable to the substrate engaging portion of the second applicator and includes a tissue reactive surface and a self-reactive surface. The self-reactive surfaces of the first and second substrates each possess reactive groups known to have complementary functionality for bonding the first and second substrates together. |
| US08608774B1 |
Bifurcated forceps
The bifurcated forceps is a tweezers-like instrument having two elongate, flattened arms joined at their mutual proximal ends, and each arm extends to a distal end having two laterally separated tines extending therefrom. The mutually facing surfaces of the corresponding tines of each arm are provided with serrations or teeth along the majority of their lengths, the facing serrations meshing with one another. The bifurcated forceps may have laterally straight arms, or laterally curved arms. Reusable forceps may be formed of surgical steel, and disposable forceps may be formed of a suitable plastic. The laterally separated tines enable the bifurcated forceps to grip a portion of tissue or other matter simultaneously at two separate points, thereby holding a greater span of the tissue clear of the underlying structure to facilitate surgical procedures and the like. |
| US08608771B2 |
Vascular occlusion device with enhanced feedback
A vascular occlusion device for occluding a body cavity includes an elongate member, a deflecting device and an indicator device. The elongate member includes a proximal end and a distal end. An embolization material is injected into the body cavity through the distal end. The deflecting device is disposed at the distal end of the elongate member and configured to be deflected by the embolization material. The indicator device is disposed at the proximal end of the elongate member. The indicator device indicates a status of occlusion of the body cavity based on deflection of the deflecting device by the embolization material. |
| US08608770B2 |
Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same
Prosthetic valves and their component parts are described, as are prosthetic valve delivery devices and methods for their use. The prosthetic valves are particularly adapted for use in percutaneous aortic valve replacement procedures. The delivery devices are particularly adapted for use in minimally invasive surgical procedures. |
| US08608763B1 |
Method for minimally invasive tendon sheath release
A device and method for minimally invasive tendon sheath release. The device and method that enables a surgeon to cut (“open”) a pulley that is obstructing a nodule and keeping a tendon from sliding smoothly. A ball tipped guide probe goes through a small incision and is used to find the edge of the pulley. Once found, the probe is guided to an end of the pulley. After proper position is assured, a cutting blade is deployed by pushing and holding a blade deployment switch. This deploys the sharp end of a retractable cutting shaft beyond the sheath. The entire device is then pushed or pulled using the device handle along the pulley until the pulley is completely released or where resistance is no longer felt. In an alternate embodiment, the cutting blade is static. |
| US08608762B2 |
Translaminar approach to minimally invasive ligament decompression procedure
Provided herein is a method for treating spinal stenosis comprising percutaneously accessing the epidural space from a first side of the spine. The first side of the spine is located on one side of the medial plane with respect to the spinal cord. A tissue removal tool is then advanced through the first side of the epidural space into the other side of the epidural space, where the other side of the epidural space is located on the other side of the medial plane of the spinal cord. Once the tissue removal tool is located on the second side of the medial plane, stenosis can be reduced using the tissue removal tool. |
| US08608759B2 |
Medical devices for suturing biological tissue
Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided. |
| US08608757B2 |
Apparatus and method for hair removal
An apparatus and method for removing hair from the surface of skin may include two elongate elements entwined with one another whereby a local mutual twist is formed along the length of the elements. Each of the elements may be held in place and put into tension by a respective one of two structural members. A method for removing hair may include moving the two structural members with the elements in tension, bringing the bottom end of one member closer to the bottom end of the second member such that the coil travels toward the bottom ends of the elements, and then bringing the top end of one member closer to the top end of the second member, such that the coil travels toward the top ends of the elements. As the coil travels between the top and bottom ends of the elements, it extracts hairs from the skin. |
| US08608756B2 |
Disc for an epilating apparatus disc assembly
A disc for an epilating apparatus disc assembly includes at least one clamping portion intended to interact with a further clamping portion of a neighboring disc when the disc and the epilating apparatus are arranged as the epilating apparatus-disc assembly, with a radially outward region of the clamping portion. The radially outward region and a radially inward region are harder than a radially intermediate region of the clamping portion. |
| US08608755B2 |
Dermatome with width plate captures
A dermatome having a main body, a blade assembly and a bottom member, where the main body includes a bottom surface and at least one capture extending from the bottom surface. The bottom member may be inserted into the at least one capture and fastened to the main body, where the blade assembly may be mounted between the fastened bottom member and the bottom surface of the main body. The captures of the main body may limit the movement of the inserted bottom member in at least three general directions and the fastener may limit the movement of the bottom member in at least a fourth general direction. |
| US08608753B2 |
Retractable tip for vitrectomy tool
A probe for a vitrectomy tool is provided having a vitreous cutter tube having a blunt tip at a distal end and adapted to be coupled at a proximal end to a handpiece of a vitrectomy tool; a retractable outer trocar tube surrounding the vitreous cutter tube having an open distal end with a sharpened edge; and a retraction mechanism coupled to a proximal end of the outer trocar for selectively extending and retracting the outer trocar tube between a first extended position wherein the sharpened edge of the outer trocar is extended beyond the blunt tip of the vitreous cutter tube to facilitate insertion into the eye and a second retracted position wherein the sharpened edge of the outer trocar is retracted behind the blunt tip of the vitreous cutter tube to facilitate safe operation of the probe. |
| US08608750B2 |
Surgical device for injecting cement in a bone cavity
A surgical device and method for injecting cement in a bone cavity includes an elongated, hollow body to be inserted partially into the cavity. The body has an inner lumen with a distal opening to expel cement therefrom. An entry plug for the cement is connected to a cement pressurized supply. The entry plug is in fluid communication with the lumen to deliver cement through the entry plug, wherein the entry plug is movably mounted on the hollow body. |
| US08608746B2 |
Derotation instrument with reduction functionality
Instruments and methods are provided for manipulating a bone anchor and a spinal fixation element. The instruments and methods disclosed herein are particularly suited to facilitate rotation of a bone anchor relative to another bone to correct the angular rotation of the vertebrae attached to the bone anchor. The instrument does not require the spinal fixation element to be inserted into the bone anchor prior to manipulation. The instrument further may be used in the insertion of the spinal fixation element into the bone anchor. |
| US08608744B2 |
Methods and apparatus for acetabular arthroplasty
A method for performing an acetabular arthroplasty in an acetabulum of an ilium may include locating an iliac canal of the ilium. The iliac canal extends from the surface of the acetabulum generally toward a portion of the iliac ridge. An impacting step impacts a non-rotating bone removal tool aligned along the iliac canal such that the non-rotating bone removal tool removes bone within the iliac canal and forms a bone void. Another step secures a fixation implant within the canal void. An acetabular implant is installed within the acetabulum over the fixation implant. |
| US08608738B2 |
Apparatus for treating a portion of a reproductive system and related methods of use
A medical device for performing a surgical procedure may include an elongate member having a proximal end, a distal end, and a lumen extending therebetween. The medical device may also include a handle connected to the proximal end of the elongate member, an end effector assembly connected to the distal end of the elongate member, and a cutting device configured to extend from the end effector assembly, wherein the cutting device has a retracted configuration in which the cutting device is withdrawn into the end effector assembly and a deployed configuration in which the cutting device extends from the end effector assembly. |
| US08608737B2 |
Methods for applying energy to tissue using a graphical interface
The invention provides a system and method for percutaneous energy delivery in an effective, manner using one or more probes. Additional variations of the system include array of probes configured to minimize the energy required to produce the desired effect. |
| US08608736B2 |
Steerable catheters and methods for making them
Apparatus are provided for performing a procedure within a patient's body that include a tubular member including proximal and distal ends, a central axis or region extending therebetween, and a distal portion extending distally from an intermediate portion to the distal end. One or more accessory lumens and a steering element lumen extend between the proximal and distal ends, the steering element lumen offset from the central region within the distal portion such that a steering plane intersects the steering element lumen and the central axis. The distal portion includes a core member extending between the intermediate portion and the distal end, and stabilization elements embedded in the core member adjacent the accessory lumen and defining a stabilization plane that intersects the steering plane at a location offset from the central region, e.g., closer to the accessory lumen than the steering element lumen. |
| US08608733B2 |
Electrosurgical apparatus with predictive RF source control
An electrosurgical generator is disclosed, which includes a closed loop control system having a sensor system configured to sense tissue and/or energy properties at a tissue site and to generate a sensor signal representative of the tissue and/or energy properties. The control system includes a controller configured to select an electrosurgical operational mode from a plurality of electrosurgical operational modes in response to the sensor signal. A radio frequency arbitrary source is also included which generates a radio frequency input signal corresponding to the selected electrosurgical operational mode and a radio frequency output stage configured to generate a treatment signal corresponding to the electrosurgical operational mode. The system includes a predictive signal processor configured to adjust the radio frequency output stage in response to the radio frequency input signal, such that the radio frequency output stage alters the treatment signal in real time based on the selected electrosurgical operational mode. |
| US08608732B2 |
Flammable substance sensing during a surgical procedure
A surgical safety apparatus for use in connection with an energizable surgical device minimizes inadvertent activation of a surgical tool when the oxygen or flammable gas level is too high. An activation circuit is connected with an energy source and with a hand piece of the tool. A sensor measures the oxygen or flammable gas near the tool and can operate in a first state to disconnect the energy source from the hand piece. In a second state the source of energy is connected to the hand piece. The sensing element is connected to the activation circuit. The sensing element signals the activation circuit to convert the activation circuit from the first state to the second state provided the oxygen or flammable gas level is safe. |
| US08608728B2 |
Delivery system and method
A connector and method of connecting are described for connecting a first and second catheter at an overlap area where the first catheter fits within the second catheter. The connector includes a collar that surrounds a portion of the overlap area and a clamp that applies a radially inward force to the collar and encircles a portion of the overlap area. |
| US08608727B2 |
Delivery system and method
A connector and method of connecting are described for connecting a first and second catheter at an overlap area where the first catheter fits within the second catheter. The connector includes a collar that surrounds a portion of the overlap area and a clamp that applies a radially inward force to the collar and encircles a portion of the overlap area. |
| US08608726B2 |
Vascular guidewire control apparatus
A controller for use with a guidewire, such as a vascular guidewire, provides a mechanism for gripping and applying a torque to the guidewire without the need to thread the guidewire axially through the controller and at a location close to a point of access of the guidewire. In one embodiment, the controller includes a side-access, multi-part assembly including a collet or other gripping element that applies a uniform radially inward force on the guidewire. In another embodiment, for use with guidewires having active electrically controllable elements, the controller integrally or removably incorporates a switch or other mechanism to initiate an energized state. The controller thereby permits ergonomic, single-handed control of an electronically steerable guidewire, including axially displacing, torquing and steering the guidewire. |
| US08608725B2 |
Eluting coils and methods of deploying and retrieving
Embodiments are directed to eluting coils having a relaxed coiled state and a straightened state that may be deployed at a fixed location within a patient's body and may accurately dispense and distribute fluids and or dissolvable substances at site specific locations of the body. Some embodiments of eluting elements are configured to be subsequently retrieved from a delivery site. |
| US08608722B2 |
Container for an anal irrigation system
The present invention relates to a container for anal irrigation. In particular it relates to a rigid container which is easy to operate and which easily is transformed from a storage configuration to a ready-to-use configuration. In one aspect the invention relates to a container for an anal irrigation system. The anal irrigation system comprises an anal probe; a reservoir for holding an irrigation liquid (e.g. water); a pump mechanism for pumping a fluid (e.g. air) into the reservoir; and a liquid tube connecting the reservoir with the anal probe. The container comprises an outer chamber wall, defining at least partly the outer dimensions of the container and an inner chamber wall arranged within the outer chamber wall, said outer chamber wall and inner chamber wall defining the reservoir. This provides a reservoir having a small surface area when filled with irrigation liquid. Thus only a low pressure is necessary to evacuate the irrigation liquid from the reservoir and out through the anal probe. |
| US08608718B1 |
Urine collection bag holder
A urine collection bag holder including a fabric strip having a hip portion and a leg portion depending therefrom and a pouch removably attached to the leg portion wherein the pouch receives a urine collection bag therein, in order to conceal the urine collection bag beneath a user's clothes. A belt that slidingly engages a continuous belt opening within the hip portion and a pair of leg straps secure the device to a user. A plurality of slits and a tube opening disposed in the leg portion receive and guide a cathether tube therethrough to connect with an upper receptacle. |
| US08608717B2 |
Urine collection apparatus
A urine collection apparatus includes a urine cover, a buffer member, and a pipe. The urine cover has an edge, a room therein, and an opening and an aperture communicated with the room, and a user's penis enters into the room via the opening. The buffer is connected to the edge of the urine cover with a connecting surface thereon to be in touch with the user's skin. The pipe is connected to the aperture of the urine cover to direct urine to a desired location. |
| US08608715B2 |
System and method to vent gas from a body cavity
One aspect of the invention is a method to vent gas from a body cavity during an endoscopic procedure. A body cavity is in fluid communication with an exhaust gas inlet of a vacuum break device. The vacuum break device has a chamber in fluid communication with both the inlet and an outlet. The chamber may comprise one or more openings in fluid communication with the atmosphere. A conduit in fluid communication with the exhaust gas outlet may be connected directly or indirectly to a suction source. The suction source may be activated. |
| US08608713B2 |
Septum feature for identification of an access port
An access port for providing subcutaneous access to a patient, and a method of identifying a subcutaneously implanted access port. The access port includes a body capturing a septum that covers a cavity defined by the body, and a pattern of protrusions extending from an outer surface of the septum away from the cavity, the pattern of protrusions detectable through palpation to identify the access port as a power-injectable port. |
| US08608711B2 |
Infusion port
Disclosed is an infusion port for regulating the inflow of an aqueous solution of an aqueous-solution pack into an external ringer spike as at least part of the ringer spike is inserted or withdrawn. The infusion port comprises an inflow part, a securing part, and a cover part. The inflow part is formed with at least one first inflow hole into which the ringer spike is inserted, so as to allow the inflow of the aqueous solution of the aqueous-solution pack as the ringer spike is inserted. Consequently, as the first inflow hole of the inflow part moves outside or inside the securing part, it is possible to regulate the flow of the aqueous solution of the aqueous-solution pack through the first inflow hole and into the ringer spike disposed inside the inflow part. |
| US08608709B2 |
Injection device for apportioning set doses
The invention concerns an injection device for apportioning set doses of a drug from a reservoir to a subject. The injection device comprises a dose setting member (20, 70) which is screwed out from the housing (30) to set a dose and pushed axially back to the housing (30) in order to expel the set dose. A scale drum (80) is axially and inrotatable coupled to the dose setting member (20, 70) such that the scale drum (80) is rotated up a thread (34) when the dose setting member (20, 70) is rotated to set a dose. When the dose setting member (20, 70) is pushed axially back to its initial position to inject the set dose, the scale drum (80) is released from its inrotatable connection in order to allow the scale drum (80) to rotate down the thread (34) and back to its zero position. |
| US08608705B2 |
Catheter securement device
A securement system (100) includes a device which permits a portion of a catheter or similar medical article to be easily anchored to a patient, desirably without the use of tape or needles and suture. A securement system for an elongated medical article comprises an anchor pad (110) and a retainer (120) mounted upon the anchor pad. The retainer (120) includes a channel (130) that has at least one abutment surface (160) corresponding to a contact surface on the medical article and a groove (210) configured to receive a spline (40) of the medical article. The medical article is placed into the channel (130). The medical article is secured within the channel by retaining at least one spline (40) and contact surface on the medical article. |
| US08608700B2 |
Microfabicated electromagnetic actuator with push-pull motion
A micromechanical electromagnetic actuator may have two separate components: a flux-generating portion and a separate movable structure. The flux-generating portion may have a plurality of conductive coils wound around a magnetically permeable material. Each coil generates a magnetic field along its axis, which is different for each of the coils. The adjacent movable structure may include magnetically permeable features, one inlaid in the movable structure and other stationary features which focus the flux produced by the flux-generating mechanism across a gap between the stationary features. By energizing each coil sequentially, a push-pull motion in the actuator may result from the force of the magnetically permeable features. This push-pull actuator may be particularly effective when used as a pumping element in a drug delivery system, or other fluidic pumping system. |
| US08608697B2 |
Insertion indicator for needle
A method and apparatus are provided for a fluid level insertion indicator that provides immediate feedback to a surgeon by draining when a tip of a needle has entered a body lumen, such as peritoneal cavity. An apparatus includes a handle connected to a hollow needle and a hollow stylet that extends through the hollow needle and has a blunt distal end that includes an opening for passing fluid. A spring biases the stylet to extend past the sharp distal end of the needle absent resistance by tissue against the stylet. An at least partially translucent pressure chamber configured to hold a quantity of fluid under pressure is connected to the proximal end of the stylet. The pressure chamber and stylet form a conduit for passing fluid through the opening in the blunt distal end when the stylet extends past the sharp distal end of the hollow needle. |
| US08608693B2 |
Tamper evident needle guard for syringes
A medicine injection device comprises a cartridge having a cartridge barrel and a plunger having a plunger shaft slidable within the cartridge barrel. The cartridge may have, e.g., a pre-filled medicine. The medicine injection device farther comprises a body having a proximal end, a distal end, and a cavity in which the cartridge barrel is disposed. The proximal end of the body may optionally form a finger grip. The medicine injection device further comprises a plunger locking mechanism attached to the proximal end of the body. The plunger locking mechanism comprises a member with an aperture slidably engaged with the plunger shaft. The locking mechanism is configured for preventing the plunger from being removed from the cartridge barrel. For example, the plunger shaft may include a locking stop, e.g., a flange, that engages with the aperture in an interference arrangement. |
| US08608692B2 |
Fluid collection self-locking, self-blunting safety needle system and syringe
The invention is related to a particular type of safety needle and syringe. The needle has a locking device which can be used with or without a syringe. The needle is cylindrical with one surface flattened out. The Blunting member is aligned within the needle. With the intake of fluids the blunting instrument moves out, blocks the needle tip and locks inside the needle. Thus preventing reuse and needle stick Injury. |
| US08608691B2 |
Angioplasty method and means for performing angioplasty
An angioplasty procedure wherein a balloon dilatation catheter is movably positioned within an anchoring catheter and which in turn is located within a guiding catheter or wherein a balloon dilatation catheter is movably positioned within a guiding catheter and the anchoring catheter in turn is positioned on the external surface of the guiding catheter, or wherein a balloon dilatation catheter is movably positioned within a catheter which serves both as a guiding catheter and anchoring catheter. Additionally, valve elements are attached to the guiding and anchoring catheters to provide points of securement between the catheters and the balloon dilatation catheter and to prevent the backflow of blood through the catheter assembly. Actuation of the valve elements allows a doctor to control the movement of the catheters. |
| US08608687B2 |
Multi-lumen endoscopic accessory and system
The embodiments of the present invention relate to an endoscopic system and accessories. In particular, the various embodiments relate to endoscopic systems in which an accessory comprises a multi-lumen device that is capable of quantitatively delivering at least a catheter, a balloon, and a needle to a site. The accessory is configured to allow for individual, independent control of its components. For example, in some embodiments, the needle and guidewire can be independently controlled. In addition, the needle may be retracted back into an inner lumen of the catheter body. Accordingly, during use, the accessory of the embodiments allows the user to maintain access to an incision site without having to exchange or remove accessories for various parts of the procedure. |
| US08608684B2 |
Impulse chamber for jet delivery device
The invention provides a jet expelling assembly comprising a reservoir and an impulse chamber assembly. The impulse chamber assembly comprises a chamber portion defining a cavity having a general axis, a piston received in the cavity along the general axis and comprising a fluid inlet, thereby defining a variable-volume impulse chamber with an outlet nozzle. The inlet comprises a conduit adapted to slidably engage a reservoir outlet during relative movement therebetween. The chamber portion is arranged stationary relative to the reservoir, whereby expelling an amount of drug from the reservoir to the impulse chamber via the inlet causes the piston to move towards the reservoir, the impulse chamber thereby receiving the expelled amount of drug. |
| US08608683B2 |
Device for infusion of at least two medicaments
A device for infusing of at least one medicament includes at least two actuators configured to cause at least two medicaments to be infused; at least one sensor configured to measure a value of at least two parameters; and a controller configured to control the at least two actuators, wherein the controller is programmed to activate the at least two actuators depending on the values of each of the at least two parameters, and wherein the controller is arranged so as to consider a dependency of the at least two medicaments. |
| US08608682B2 |
Method and device for irrigation of body cavities
A pressure and a vision regulation method and device for irrigation of a body cavity (1), in which method an inflow liquid pump (2) pressurizes the irrigation liquid in a feed line (13) and in which an outflow device (3) or an external suction source (20) drains the irrigation liquid from the body cavity (1) through a tubing (16) into a waste container (17) and in which a control unit (4) controls either the inflow liquid pump (2) only or both the inflow liquid pump (2) and the outflow device (3) depending on an inflow irrigation liquid pressure from a pressure sensor (5), where the first control unit (4) compares the inflow irrigation liquid pressure and flow with pressures calculated to correspond to pressure in the body cavity for the respective flow for a nominal surgical site and that a matching between the calculated values and the inflow irrigation liquid pressures is made by altering the effect of either the inflow liquid pump (2) only or the inflow liquid pump (2) and/or the outflow device (3) and/or the shut off valve. The above-mentioned pressure registration method and the device for irrigation of a body cavity is combined with an method for detecting blood cells, red blood cells, haemoglobin and/or debris in liquid coming from a surgical site so an automatically control and rinsing system is achieved keeping a clear vision in the viewing area of the operational site. |
| US08608677B2 |
Device for carrying the load of injured soft tissue
The present invention relates to the field of therapeutic and/or injury support devices. In one form, the invention relates to a device for the relative protection and treatment of injured muscles, tendons and other soft tissue, as well as a method of utilizing this device. In one particular form, the present invention relates to providing an external support structure to assist in the load carrying function of injured soft tissue. |
| US08608673B2 |
Bathtub for beauty and health care and a physic solution
The present patent application provides a bathtub for beauty and health care and a physic solution. The bathtub comprises a housing and a tub which is formed by an inner tub and an outer tub nested together, there is a clearance between the inner tub and the outer tub, at least a group of ultrasonic generating elements are arranged on the wall of the outer tub and used for generating ultrasonic so as to vibrate water inside the outer tub and then vibrate physic solution inside the inner tub. Beauty and health care for a whole body can be realized by filling the physic solution into the inner tub, meanwhile, when a user is soaking in the physic solution, the physic solution is vibrated along with the ultrasonic generating elements, so that the physic solution can be introduced into the body effectively. In order to keep the temperature of the never goes too high or too low, a circulating pump is used to flow the physic solution circularly. Safe insulation effect is achieved by using hot water in the outer tub to heat the physic solution in the inner tub. The ultrasonic generating element can be controlled according to the actual situation and requirement of the user, and individual records and individual control for user can be realized, so that intelligent control performance of the bathtub for beauty and health care can be improved. |
| US08608664B2 |
Electrode
An object of the present invention is to provide a microelectrode capable of recording action potentials of nerve cellsneurons as large-amplitude waveforms and being appropriate for multi-channeling. The electrode 1 of the present invention comprises a conductive linear core material 2, an insulating coating layer 3a with which the outer circumference of the linear core material is coated, and an extending part 3b formed by extending the end part of the coating layer on one tip side of the linear core material beyond the tip in the longitudinal direction of the linear core material, in which a cavity that opens in the extending direction is formed within the extending part. |
| US08608663B2 |
Pulse wave period measuring apparatus, pulse wave period measuring method, heartbeat period measuring method, and recording medium
A pulse wave period measuring apparatus according to an embodiment of the present invention detects a pulse wave of a subject, detects a maximum value and a minimum value in a predetermined period of the pulse wave, calculates one or more reference values between the maximum value and the minimum value in the predetermined period, based on one or more internally dividing ratios common to plural predetermined periods of the pulse wave, calculates two or more times in the predetermined period, the apparatus calculating the two or more times at which the pulse wave intersects with the one or more reference values, calculates a time period between each calculated time in the predetermined period and a corresponding calculated time in a last period before the predetermined period, as a pulse wave period of the pulse wave, calculates a variation of pulse wave periods, for two or more pulse wave periods calculated between the predetermined period and the last period before the predetermined period, and calculates, based on the variation of the pulse wave periods, the stability of measuring the pulse wave periods. |
| US08608662B2 |
Ultrasound diagnosis apparatus
An apparatus has: an ultrasound probe that transmits and receives ultrasound waves to and from a subject and has an ultrasound transmission/reception surface; an acoustic coupler that has a different shape for each type and is attachable and detachable so as to cover the ultrasound transmission/reception surface; a generator that, based on the ultrasound waves received by the ultrasound probe, generates an image expanding in a depth direction from the ultrasound transmission/reception surface; and an analyzer that, based on presence/absence and shape of an acoustic coupler region within the image generated by the generator, identifies presence/absence of mounting of the acoustic coupler and a type of the mounted acoustic coupler. Consequently, the apparatus is capable of identifying the acoustic coupler though the ultrasound probe and the acoustic coupler are not provided with special structures. |
| US08608651B2 |
Access device for minimally invasive surgery
A retractor has a proximal portion comprising a first side portion having a first longitudinal edge and a second side portion having a second longitudinal edge. The first and second portions being movable relative to each other such that the first and second longitudinal edges can be positioned in close proximity to each or spaced apart by a selected distance. A distal portion has an outer surface and an inner surface partially defining a passage. The distal portion is capable of having a configuration when inserted within the patient wherein the cross-sectional area of the passage at a first location is greater than the cross-sectional area of the passage at a second location, wherein the first location is distal to the second location. |
| US08608649B2 |
In-vivo visualization system
Several embodiments of the present invention are generally directed to medical visualization systems that comprise combinations of disposable and reusable components, such as catheters, functional handles, hubs, optical devices, etc. Other embodiments of the present invention are generally directed to features and aspects of an in-vivo visualization system that comprises an endoscope having a working channel through which a catheter having viewing capabilities is routed. the catheter may obtain viewing capabilities by being constructed as a vision catheter or by having a fiberscope or other viewing device selectively routed through one of its channels. The catheter is preferably of the steerable type so that the distal end of the catheter may be steered from its proximal end as it is advanced with the body. A suitable use for the in-vivo visualization system includes but is not limited to diagnosis and/or treatment of the duodenum, and particularly the biliary tree. |
| US08608648B2 |
Articulation joint
A video endoscope system includes a reusable control cabinet and an endoscope that is connectable thereto. The endoscope may be used with a single patient and then disposed. The endoscope includes an illumination mechanism, an image sensor, and an elongate shaft having one or more lumens located therein. An articulation joint at the distal end of the endoscope allows the distal end to be oriented by the actuators in the control cabinet or actuators in a control handle of the endoscope. Fluidics, electrical, navigation, image, display and data entry controls are integrated into the system along with other accessories. |
| US08608647B2 |
Systems and methods for articulating an elongate body
Systems and methods for articulating an elongate articulatable body which is adapted to be delivered within a body cavity. Particularly, systems and methods for enhancing an articulating force on the elongate body without increasing an actuation force applied by an actuator. |
| US08608644B1 |
Remote interactive sexual stimulation device
A therapeutic adult cyber sex toy for use over the internet incorporating the premise of video chat interaction with programming capable of supporting interpersonal sexual experience utilizing a set of communicating controllers produced in the form of male and female genitalia. The controllers of the present invention correlate to that of the partner. The male's controller is in the form of a mock vagina having an optical sensor at its opposed end along with buttons for inducing commands in a linked female's controller, the female controller is in the form of a dildo and has a similar command interface for interacting with the male's controller. Partners are capable of affecting each others experience by varying settings in the others controller while using their own, such variables can include vibration, heat, auditory/video feedback and frequency. |
| US08608642B2 |
Methods and devices for treating morbid obesity using hydrogel
An environmentally sensitive hydrogel material swells or collapses in response to a parameter such as pH level associated with consumption of food by a patient. This swelling or collapsing is harnessed to treat morbid obesity or some other condition of the patient. The swelling or collapsing of the hydrogel may be used to tighten a gastric band or gastric valve when the patient starts eating; then loosen the band or valve when the patient is between meals. The swelling or collapsing of the hydrogel may also be used to increase the size of a space occupying device in the patient's stomach when the patient starts eating; then decrease the size of the space occupying device when the patient is between meals. The swelling or collapsing of the hydrogel may also be used to selectively restrict the absorption of nutrients within a patient's gastrointestinal tract, such as in the duodenum. |
| US08608640B2 |
Implantable sling for the treatment of incontinence and method of using the same
A method of treating urinary incontinence includes forming a first incision exposing a urethral region a patient and forming first and second suprapubic incisions. The method includes tunneling an introducer from the first suprapubic incision superficially anterior to a pubic symphysis of the patient and out of the first incision, attaching a first portion of an implant to the introducer and retracting the introducer and the first portion of the implant from the first incision to the first suprapubic incision, and repeating these maneuvers on the contralateral side. The method includes forming third and fourth incisions and tunneling a suitable introducer from the third/fourth incisions through separate obturator foramen of the patient to allow retracting portions of the implant from the first incision back through to the third/fourth incision with the introducer. |
| US08608639B2 |
Resilient device
An intravaginal device has a working portion (e.g., intravaginal urinary incontinence device suppository, tampon) and an anchoring portion comprising at least one member extending beyond at least one end of the working portion to maintain the working portion in place during use. |
| US08608638B2 |
Methods and systems for treating tinnitus
Methods and systems for treating tinnitus are provided. Some embodiments include a method of providing a primary audio signal having a primary peak portion substantially centered at about a tinnitus frequency of a patient. The method may also include combining the primary audio signal with a general audio signal to generate a combined sound. The method may also include exposing the patient to the combined sound so that the patient hears the combined sound, to diminish a perception by the patient of tinnitus. |
| US08608636B2 |
Ventricular assist device cannula and ventricular assist device including the same
Provided is a ventricular assist device cannula, and more particularly, a ventricular assist device cannula with electrodes. An exemplary embodiment of the present invention provides a ventricular assist device cannula with electrodes, including: a connecting tube connecting an incision of a body tissue and a ventricular assist device so that blood can flow; and electrodes connected with the connecting tube and contacting the incision of the body tissue to transfer an electric signal to the body tissue. |
| US08608635B2 |
TET system for implanted medical device
A TET system is operable to vary an amount of power transmitted from an external power supply to an implantable power unit in accordance with a monitored condition of the implantable power unit. The amount of power supplied to the implantable power unit for operating a pump, for example, can be varied in accordance with a cardiac cycle, so as to maintain the monitored condition in the power circuit within a desired range throughout the cardiac cycle. |
| US08608634B2 |
Coil for magnetic stimulation and methods for using the same
A magnetic stimulator, which may be used as a transcranial magnetic stimulation (TMS) device, and a method for its use are disclosed. The stimulator comprises a frame and an electrically conductive coil having a partially toroidal or ovate base and an outwardly projecting extension portion. The frame may be a flexible or malleable material and may be nonconductive. The electrically conductive coil may comprise one or more windings of electrically conductive material (such as a wire) coupled to the frame. The coil is electrically connected to a power supply. The device may be placed adjacent to or in contact with the body of a subject, such as on the head of a subject. The device may be used on humans for treating certain physiological conditions, such as cardiovascular or neurophysiological conditions, or for studying the physiology of the body. This device is useful in studying or treating neurophysiological conditions associated with the deep regions of the brain, such as drug addiction and depression. |
| US08608619B2 |
Automatic transmission and control method therefor
When the temperature of oil supplied to an electrical oil pump is detected and the oil temperature is lower or higher than normal oil temperature, a gradient threshold value smaller than that at normal oil temperature is set, a gradient of a road surface on which a vehicle is stopped is detected, and an idle stop is prohibited when the detected gradient of the road surface is larger than the set gradient threshold value. |