最新美国发明专利
Document Document Title
US08610136B2 Thermally optimised LED chip-on-board module
A LED Chip-on-Board (COB) module comprises a plurality of LED die arranged on a substrate in one or more radially concentric rings about a center point such that each LED die is azimuthally offset from neighboring LED die. The module includes thermal conduction pads each having lateral dimensions at least as large as the combined lateral dimensions of the LED die attached to it and a total surface area at least five times larger than the total surface area of all the LED die attached to it. At the same time, the total light emission area of the module is no greater than four times larger than the combined total surface emission area of all the individual LED die disposed on the substrate. A variety of configurations are possible subject to these criteria, which permit good packing density for enhanced brightness while ensuring optimal heat transfer. A method of manufacturing the module is also provided.
US08610129B2 Compound semiconductor image sensor
A stack-type image sensor using a compound semiconductor. The stack-type image sensor includes a stack of photoelectric conversion units which are sequentially arranged in a light incident direction and which absorb light in ascending order of a wavelength from shortest to longest.
US08610125B2 Nanotube array light emitting diodes
Carbon nanotube (CNT)-based devices and technology for their fabrication are disclosed. The planar, multiple layer deposition technique and simple methods of change of the nanotube conductivity type during the device processing are utilized to provide a simple and cost effective technology for large scale circuit integration. Such devices as p-n diode, CMOS-like circuit, bipolar transistor, light emitting diode and laser are disclosed, all of them are expected to have superior performance then their semiconductor-based counterparts due to excellent CNT electrical and optical properties. When fabricated on semiconductor wafers, the CNT-based devices can be combined with the conventional semiconductor circuit elements, thus producing hybrid devices and circuits.
US08610121B2 Methods for discretized processing and process sequence integration of regions of a substrate
The present invention provides methods and systems for discretized, combinatorial processing of regions of a substrate such as for the discovery, implementation, optimization, and qualification of new materials, processes, and process sequence integration schemes used in integrated circuit fabrication. A substrate having an array of differentially processed regions thereon is processed by delivering materials to or modifying regions of the substrate.
US08610118B2 Flexible display panel having curvature that matches curved surface of vehicle part
The object of the invention is to provide a method for fabricating a semiconductor device having a peeled layer bonded to a base material with curvature. Particularly, the object is to provide a method for fabricating a display with curvature, more specifically, a light emitting device having an OLED bonded to a base material with curvature. An external force is applied to a support originally having curvature and elasticity, and the support is bonded to a peeled layer formed over a substrate. Then, when the substrate is peeled, the support returns into the original shape by the restoring force, and the peeled layer as well is curved along the shape of the support. Finally, a transfer object originally having curvature is bonded to the peeled layer, and then a device with a desired curvature is completed.
US08610117B2 Light emitting device and electronic equipment
A display device capable of keeping the luminance constant irrespective of temperature change is provided as well as a method of driving the display device. A current mirror circuit composed of transistors is placed in each pixel. A first transistor and a second transistor of the current mirror circuit are connected such that the drain current of the first transistor is kept in proportion to the drain current of the second transistor irrespective of the load resistance value. The drain current of the first transistor is controlled by a driving circuit in accordance with a video signal and the drain current of the second transistor is caused to flow into an OLED, thereby controlling the OLED drive current and the luminance of the OLED.
US08610115B2 Organic electroluminescent devices
This invention relates to an organic electroluminescent device (1) produced with less effort comprising a substrate (2), a substrate electrode (3) on top of the substrate (2), an electroluminescent layer stack (4) with at least one organic light emitting layer on top of the substrate electrode (3), a counter electrode (5) at least covering the electroluminescent layer stack (4), and a short prevention layer (6) covering the counter electrode (5) establishing a double layer (DL) of counter electrode (5) and short prevention layer (6), and an electrically isolating layer at least partly on top of the short prevention layer, where a tensile stress (TS) is induced to the double layer (DL) by the short prevention layer (5) suitable to roll-up (10) the double layer (DL) after deposition of the electrically isolating layer (8) adjacent to a cut introduced at least to the double layer (DL) in an area, where the double layer (DL) is arranged on top of the electroluminescent layer stack (4) suitable to electrically disconnect the counter electrode (5) from the substrate electrode (3), where the electrically isolating layer (8) at least partly covers the area of the double layer with introduced cut (7) to partly dissolve the electroluminescent layer stack (4) to weaken the adhesion of the double layer to the electroluminescent layer stack adjacent to the cut to roll-up the double layer in the vicinity of the cut. The invention further relates to a method of manufacturing such an OLED device.
US08610114B2 Radiation emitting device
A radiation emitting device comprising a first electrode, which emits first charge carriers having a first charge during operation, a first charge carrier transporting layer, which comprises a fluorescent substance, a second charge carrier transporting layer, which contains a phosphorescent substance, and a second electrode, which emits second charge carriers having a second charge during operation, wherein during operation the second charge carrier transporting layer is largely free of first charge carriers.
US08610113B2 Material for a hole transport layer with p-dopant
A material for a hole transport layer has a p-dopant. The dopant forms with the hole transport material a charge transfer complex. A metal component in solution is processed with the hole transport matrix material in solution to form the hole transport layer.
US08610112B2 Charge-transporting polymer, composition for organic electroluminescent element, organic electroluminescent element, organic EL display, and organic EL lighting
A subject for the invention is to provide a charge-transporting polymer having high hole-transporting ability and excellent solubility and film-forming properties and a composition for organic electroluminescent element which contains the charge-transporting polymer. Another subject for the invention is to provide an organic electroluminescent element which has a high current efficiency and high driving stability. The charge-transporting polymer comprises a group represented by the following formula (1) as a side chain: wherein in formula (1), the benzocyclobutene ring may have one or more substituents. The substituents may be bonded to each other to form a ring. The spacer represents a group which links the benzocyclobutene ring to the main chain of the charge-transporting polymer through three or more single bonds.
US08610111B2 Bistable carbazole compounds
Bistable carbazole compounds of formula (I) are described, wherein M is Fe, Co, Ru or Os, preferably Fe, useful as basic functional units for computing systems based on the QCA (Quantum Cellular Automata) paradigm; a process for their preparation is also described.
US08610110B2 Optoelectronic component comprising neutral transition metal complexes
The invention relates to the use of compositions as emitters or absorbers in an electronic component, wherein the compositions have a first neutral transition metal complex and a second neutral transition metal complex. According to the invention, the first transition metal complex and the second transition metal complex together form a column structure. The invention further relates to a method for the production of electronic components having such compositions.
US08610109B2 Light emitting device
A triplet light emitting device which has high efficiency and improved stability and which can be fabricated by a simpler process is provided by simplifying the device structure and avoiding use of an unstable material. In a multilayer device structure using no hole blocking layer conventionally used in a triplet light emitting device, that is, a device structure in which on a substrate, there are formed an anode, a hole transporting layer constituted by a hole transporting material, an electron transporting and light emitting layer constituted by an electron transporting material and a dopant capable of triplet light emission, and a cathode, which are laminated in the stated order, the combination of the hole transporting material and the electron transporting material and the combination of the electron transporting material and the dopant material are optimized.
US08610107B2 Light emitting device having a well structure different of a multi-quantum well structures
A light emitting device is provided. The light emitting device comprises an active layer comprising a plurality of well layers and barrier layers. The barrier layers comprise a first barrier layer which is the nearest to a second conductive type semiconductor layer and has a first band gap, a second barrier layer having a third band gap, and a third barrier layer having the first band gap between the second barrier layer and a first conductive type semiconductor layer. The well layers comprise a first well layer having a second band gap between the first and the second barrier layers, and a second well layer between the second barrier layer and the third barrier layer. The second barrier layer is disposed between the first and the second well layers, and the third band gap is narrower than the first band gap and wider than the second band gap.
US08610106B2 Semiconductor light emitting device
According to one embodiment, a semiconductor light emitting device includes an n-type semiconductor layer, a p-type semiconductor layer and a light emitting part. The light emitting part is provided between the n-type semiconductor layer and the p-type semiconductor layer and includes a first light emitting layer. The first light emitting layer includes a first barrier layer, a first well layer, a first n-side intermediate layer and a first p-side intermediate layer. The barrier layer, the well layer, the n-side layer and the p-side intermediate layer include a nitride semiconductor. An In composition ratio in the n-side layer decreases along a first direction from the n-type layer toward the p-type layer. An In composition ratio in the p-side layer decreases along the first direction. An average change rate of the In ratio in the p-side layer is lower than an average change rate of the In ratio in the n-side layer.
US08610103B2 Flexible microcavities through spin coating
A mechanically flexible array of optically pumped vertical cavity surface emitting lasers, fabricated using spin coating. The array uses InGaP colloidal quantum dots as an active medium and alternating polymer layers of different refractive indices as Bragg mirrors. Enhanced spontaneous emission is produced. The flexible array can be peeled off a substrate, producing a flexible structure that can conform to a wide variety of shapes, and having an emission spectrum that can be mechanically tuned. The flexible array can be used to create a flexible infrared light bandage.
US08610100B2 Apparatus comprising nanowires
A method including: a) depositing a masking material over a substrate comprising silicon; b) removing the masking material using a first process that removes the masking material in preference to silicon; c) removing silicon using a second process that removes silicon in preference to the masking material; d) continuously repeating the sequence of steps a), b) and c) to control the creation of nanowires; and e) stopping repetition of the sequence of steps a), b) and c).
US08610098B2 Phase change memory bridge cell with diode isolation device
Memory cells are described along with arrays and methods for manufacturing. An embodiment of a memory cell as described herein includes a second doped semiconductor region on a first doped semiconductor region and defining a pn junction therebetween. A first electrode on the second doped semiconductor region. An insulating member between the first electrode and a second electrode, the insulating member having a thickness between the first and second electrodes. A bridge of memory material across the insulating member, the bridge having a bottom surface and contacting the first and second electrodes on the bottom surface, and defining an inter-electrode path between the first and second electrodes across the insulating member, the inter-electrode path having a path length defined by the thickness of the insulating member, wherein the memory material has at least two solid phases.
US08610097B2 Method for the continuous production of water-absorbent polymer particles
A process for continuously preparing water-absorbing polymer beads by determining at least one particulate delivery material mass flow by means of incident electromagnetic waves.
US08610094B2 Terahertz wave generator and method of generating terahertz wave
Disclosed is a terahertz wave generator which includes a first light source outputting a first light having a first frequency; a second light source outputting a second light having a second frequency different from the first frequency; a second harmonic generation unit performing second harmonic conversion on the first and second lights to generate a third light and a fourth light; and a photomixer converting a mixing light of the third and fourth lights into a terahertz wave alternating signal and outputting a terahertz wave.
US08610091B2 Charged particle beam writing apparatus and charged particle beam writing method
A charged particle beam writing apparatus according to an embodiment, includes a first dose calculating unit configured to calculate a first dose map for each set of a proximity effect correction coefficient map and a base dose map of a beam; a dimension map creation unit configured to create a dimension map of a pattern by using the first dose map calculated for each set; an adder configured to add dimensions of all sets for each position of the dimension map by using the dimension map of each set; a set map creation unit configured to create a set of a proximity effect correction coefficient map and a base dose map by using an added dimension map after addition; and a second dose calculating unit configured to calculate a second dose map by using a created set of the proximity effect correction coefficient map and the base dose map.
US08610090B2 Ion beam sample preparation thermal management apparatus and methods
Disclosed are embodiments of an ion beam shield for use in an ion beam sample preparation apparatus and methods for using the embodiments. The apparatus comprises an ion beam irradiating means in a vacuum chamber that may direct ions toward a sample, a shield blocking a portion of the ions directed toward the sample, and a shield retention stage with shield retention means that replaceably and removably holds the shield in a position. The ion beam shield has datum features which abut complementary datum features on the shield retention stage when the shield is held in the shield retention stage. The shield has features which enable the durable adhering of the sample to the shield for processing the sample with the ion beam. The complementary datum features on both shield and shield retention stage enable accurate and repeatable positioning of the sample in the apparatus for sample processing and reprocessing.
US08610088B2 Multispectral illumination device
An illumination device includes at least four semiconductor radiation sources (18) for emitting optical radiation in respectively different emission wavelength ranges. At least one color splitter (22.1, 22.2, 22.3), which is reflective for optical radiation of the respective semiconductor radiation source (18), is assigned to each of at least three of the semiconductor radiation sources (18). The semiconductor radiation sources (18) and the color splitters (22.1, 22.2, 22.3) are arranged such that the optical radiation, which is emitted in each case from each of the semiconductor radiation sources (18), is coupled into a common illumination beam path section (24). In each case, one collimating unit (20.1, 20.2, 20.3, 20.4), which collimates the optical radiation emitted by the respective semiconductor radiation source (18), is arranged in the beam path sections from the semiconductor radiation sources (18) to the color splitters (22.1, 22.2, 22.3).
US08610087B2 Method for measuring tritium or other radiation for dismantling
The invention relates to a kit for detecting β-radiation on a solid surface in a manner that is not destructive to the solid surface, said kit including at least two films that are sensitive to at least two different types of radiation, including the β-type.
US08610082B2 Drawing apparatus and method of manufacturing article
A drawing apparatus performs drawing on a substrate with charged particle beams. The drawing apparatus includes an irradiation optical system including a collimator lens; an aperture array configured to split the charged particle beam into a plurality of charged particle beams; a converging lens array configured to form a plurality of crossovers of the plurality of charged particle beams; and a projection optical system including an element in which a plurality of apertures corresponding to the plurality of crossovers are formed, and a plurality of projection lenses corresponding to the apertures. The converging lens array includes converging lenses disposed such that each of the plurality of crossovers, which are formed by the converging lenses from the charged particle beam incident on the aperture array at incidence angles associated with aberration of the irradiation optical system, is aligned with corresponding one of the apertures in the element.
US08610081B2 Systems and methods for generating control signals in radiation detector systems
Systems and methods for generating control signal in radiation detector systems are provided. One system includes a scheduling architecture having at least one anode channel connected to a detector of the radiation detector system. The anode channel includes a charge sensitive amplifier and a signal shaper, wherein the anode channel is configured to generate at least one control signal to control data acquisition by the detector. The scheduling architecture also includes at least one shaper timer configured having a time constant to define timing for the generation of the control signal without using a clock.
US08610073B2 Monochromatic wavelength variable terahertz wave generation/detection system and method
To provide a monochromatic wavelength variable terahertz wave generation/detection system that has high detection sensitivity at room temperature and that can quickly operate at the same time, excitation light of monochromatic wavelength generated from one excitation light source is inputted to a wavelength variable terahertz wave source and a nonlinear light conversion terahertz wave detector through an excitation light phase control optical system shown below. The excitation light phase control optical system includes, on a light path of the excitation light, an optical element capable of simultaneously changing an incidence angle of the excitation light to a generation point of a terahertz wave in the wavelength variable terahertz wave source and an incidence angle of the excitation light to an incidence point of the terahertz wave in the nonlinear light conversion terahertz wave detector to set both the generation point and the incidence point at the same time on the focal points in a confocal optical system.
US08610072B2 Gas exchange system flow configuration
System flow path designs that minimize the impact of gas diffusion sources and sinks. By reducing the magnitude of parasitic sources and sinks, lower rates of photosynthesis and transpiration can be more accurately measured, e.g., without the need for extensive empirical compensation. According to one aspect, a sensor head for use in a gas exchange analysis system includes a sample chamber defining a measurement volume for analysis of a sample, the sample chamber having an inlet and an outlet, and a flow splitting mechanism located proximal to the sample chamber, the mechanism configured to split a gas flow received at an input port from a remote source to a first output port and to a second output port, wherein the first output port is coupled with the inlet of the sample chamber. The sensor head also typically includes a first gas analyzer coupled with the outlet of the sample chamber and configured to measure a concentration of one or more gases, and a second gas analyzer coupled with the second output port of the flow splitting mechanism and configured to measure a concentration of the one or more gases. Advantageously, gas diffusion sources and sinks are reduced due to the proximity of the flow splitting mechanism with the sample chamber and gas analyzers. This advantageously reduces measurement error associated with or attributable to gas diffusion sources and sinks. The proximity advantage derives from minimizing the joints, gaskets, fittings, tubing lengths, and materials all prone or susceptible to gas diffusion.
US08610070B2 Pixel-level optical elements for uncooled infrared detector devices
Pixel-level monolithic optical element configurations for uncooled infrared detectors and focal plane arrays in which a monolithically integrated or fabricated optical element may be suspended over a microbolometer pixel membrane structure of an uncooled infrared detector element A monolithic optical element may be, for example, a polarizing or spectral filter element, an optically active filter element, or a microlens element that is structurally attached by an insulating interconnect to the existing metal interconnects such that the installation of the optical element substantially does not impact the thermal mass or thermal time constant of the microbolometer pixel structure, and such that it requires little if any additional device real estate area beyond the area originally consumed by the microbolometer pixel structure interconnects.
US08610068B2 Optical position detection device and equipment with position detection function
An optical position detection device includes a first detection light source unit that outputs a detection light from one side to the other side in a first direction, a second detection light source unit that is separated from the first detection light source unit along a second direction crossing the first direction, and outputs a detection light from the one side to the other side in the first direction, a light detection unit having sensitivity toward the other side in the first direction, and a position detection unit that detects the position of the object based on the light reception in the light detection unit.
US08610063B2 System for transmitting an electrical signal, in particular frequency-related, and radiation measurement device equipped with such a system
A system for transmitting an electrical signal, notably a frequency-related electrical signal, includes two conducting lines each having a central conductor surrounded by a conducting sheath, the lines being coupled and isolated from one another at each end by a transformer. The central conductor of a line is linked at the input of the system to a coil of a first transformer and at the output of the system to a coil of the second transformer. The invention is applied for example for the transmission of strongly disturbed environment measurement signals.
US08610057B2 Ion selection apparatus and method
An ion mobility spectrometer or other ion apparatus has two or three grid electrodes 51 and 52; 151 to 153; 106 and 107; 106′ and 107′ extending laterally of the ion flowpath. An asymmetric waveform with a dc compensating voltage is applied between the electrodes to produce a field parallel to the ion flow path that affects ions differently according to their field-dependent mobility. This filters or delays different ions selectively in their passage to an ion detector 11, 111, 111′ to facilitate discrimination between ions that would otherwise produce a similar output.
US08610047B2 Image sensor pixel having a static transistor and a dynamic transistor coupled to a sensing capacitor and driving method thereof
An image sensor pixel and a driving method thereof are provided. The image sensor pixel comprises a photodiode, a sensing capacitor, a static transistor and a dynamic transistor. A first terminal of the photodiode is coupled to a bias line. A control terminal of the static transistor is coupled to a static gate line, and a first terminal of the static transistor is coupled to a first terminal of the sensing capacitor and a second terminal of the photodiode. A control terminal of the dynamic transistor is coupled to a dynamic gate line, and a first terminal of the dynamic transistor is coupled to a second terminal of the sensing capacitor.
US08610046B2 Image readout circuit with capacitor that is shared between sample and hold and buffer
A switched capacitor sample and hold buffer that can be used, for example, in a CMOS image sensor. The switched capacitor sample and hold circuit has large output swings, low noise and reduced capacitor area compared to the traditional switched capacitor approach.
US08610040B2 Electric induction oven
An electric oven includes a box casing presenting side walls, a rear wall, an upper wall and a lower wall, an opening and a closure door for this latter, the walls bounding an oven cavity heated by heating structure functionally associated with at least one of the walls. The heating structure is arranged to heat the cavity by induction and includes a generator arranged to generate an electromagnetic field, an electrically insulating material disposed between the generator and the oven wall at which the heating structure is positioned, and magnetically insulating structure is disposed on the outside of the oven with reference to the wall, the generator, the electrically insulating structure and the magnetically insulating structure defining a single, layered structure fitted to the oven wall.
US08610036B2 Device and method for monitoring a heating appliance
A device for monitoring a heating apparatus that includes a default deactivated motion detector for determining whether a person is proximate the heating apparatus. The device includes a default deactivated heat sensor for determining whether the heating apparatus has a temperature that is above a threshold. The device includes an internal timer for cyclically repeating a first countdown. The heat sensor is temporarily activated once during each of the repeated first countdowns. The internal timer performs a second countdown when the activated heat sensor determines that the heating apparatus has the temperature that is above the threshold. The second countdown is reset each time the motion detector determines that a person is proximate the heating apparatus. The device includes an alarm configured to notify a user when the internal timer reaches the end of the second countdown.
US08610034B2 Heater, manufacturing apparatus for semiconductor device, and manufacturing method for semiconductor device
A heater for heating a wafer includes elements that are arranged at a distance from one another in a rotationally symmetrical fashion with respect to a shaft extending through a center of the wafer, an electrode being provided to each of the elements to heat the wafer uniformly.
US08610032B2 Laser heating of aqueous samples on a micro-optical-electro-mechanical system
A system of heating a sample on a microchip includes the steps of providing a microchannel flow channel in the microchip; positioning the sample within the microchannel flow channel, providing a laser that directs a laser beam onto the sample for heating the sample; providing the microchannel flow channel with a wall section that receives the laser beam and enables the laser beam to pass through wall section of the microchannel flow channel without being appreciably heated by the laser beam; and providing a carrier fluid in the microchannel flow channel that moves the sample in the microchannel flow channel wherein the carrier fluid is not appreciably heated by the laser beam.
US08610028B2 Laser processing device
An apparatus comprises a table, a source emitting polarized laser light, a source emitting laser light, a plate changing the polarization direction of the laser light, a plate splitting the laser light into a laser light having polarization in an X direction and a laser light component having polarization in a Y direction, a plate orienting the polarization direction of the laser light to the X direction, a lens converging the laser light components, a lens arranged in parallel with the lens along the X direction and converges the laser light component, a control section controlling a device such that a converging point of the laser light component is located at a predetermined position with reference to a front face by detecting a reflected light, and a control section moving the table along a line while making the X direction substantially coincide with the line.
US08610022B2 Impedance spectroscopy system and catheter for ischemic mucosal damage monitoring in hollow viscous organs
Methods of using the device for conducting business transactions are also included. An impedance spectroscopy system for monitoring ischemic mucosal damage in hollow viscous organs comprises a sensor catheter and an impedance spectrometer for electrically driving the catheter to obtain a complex tissue impedance spectrum. Once the catheter is in place in one of a patient's hollow viscous organs, the impedance spectrometer obtains the complex impedance spectrum by causing two electrodes in the tip of the catheter to inject a current into the mucosal tissue at different frequencies, while two other electrodes measure the resulting voltages. A pattern recognition system is then used to analyze the complex impedance spectrum and to quantify the severity of the mucosal injury. Alternatively, the complex impedance spectrum can be appropriately plotted against the spectrum of normal tissue, allowing for a visual comparison by trained personnel.
US08610021B2 Stacker device for stacking flat articles on edge, and a postal sorting machine equipped with at least one such device
A sorting outlet device including a support surface on which a stack of flat articles is formed by accumulation as the flat articles are inserted, accumulated, and pushed on-edge one-by-one in a main direction against a retaining element for retaining the stack, which element is provided at the front end of the stack. The support surface is mounted to be free to move in translation in the main direction, being moved synchronously with the movement of the retaining element in the main direction. The retaining element is also mounted to move relative to the frame under the effect of accumulation of said articles and associated with means of the winder or counter weight type arranged so as to exert a return force on the stack of flat articles in such a manner as to retain it. A postal sorting machine is equipped with at least one such stacker device.
US08610019B2 Methods for sorting materials
Disclosed herein is the use of differences in x-ray linear absorption coefficients to process ore and remove elements with higher atomic number from elements with lower atomic numbers. Use of this dry method at the mine reduces pollution and transportation costs. One example of said invention is the ejection of inclusions with sulfur, silicates, mercury, arsenic and radioactive elements from coal. This reduces the amount and toxicity of coal ash. It also reduces air emissions and the energy required to clean stack gases from coal combustion. Removal of said ejected elements improves thermal efficiency and reduces the pollution and carbon footprint for electrical production.
US08610018B2 Methods and apparatus for selectively processing eggs having identified characteristics
Methods and apparatus for processing eggs based upon a characteristic such as gender are provided. Material is extracted from each of a plurality of live eggs, the extracted material is assayed to identify eggs having the characteristic, and then eggs identified as having the characteristic are processed accordingly.
US08610017B2 Capacitive input switch
In a capacitive input switch that is accommodated in a housing of electronic equipment, the capacitive input switch includes a rigidity imparting layer having rigidity and a laminate sheet laminated on the rigidity imparting layer. The rigidity imparting layer and the laminate sheet are three dimensionally formed. The laminate sheet is formed by a substrate sheet, a conductive pattern layer for capacitor formation, and a decorative layer that is laminated at least on any one of the substrate sheet and the conductive pattern layer. A separate conductor is caused to contact with the conductive pattern layer and the conductive pattern layer is caused to be electrically connected to an external electric circuit by the conductor.
US08610014B2 Electrical switching apparatus, and stored energy assembly and energy storage and release control mechanism therefor
An energy storage and release control mechanism is provided for a stored energy assembly of an electrical switching apparatus. The stored energy assembly includes a shaft, a stored energy mechanism, and a charging mechanism, such as a charging cam. The charging cam is movable to pivot upon the shaft, thereby charging the stored energy mechanism. The energy storage and release control mechanism includes a ratchet coupled to the charging cam and including a plurality of teeth, a mounting assembly, and a plurality of pawl assemblies. Each pawl assembly includes a pawl pivoting between an engaged position corresponding to the pawl engaging the teeth of the ratchet to resist inappropriate movement of the charging handle, and a disengaged position corresponding to the pawl not engaging the teeth of the ratchet. Preferably, first and second pawl assemblies include first and second pawls, respectively, wherein only one of the first and second pawls engages the teeth of the ratchet at a time.
US08610008B2 Conveyor belt scale with conveyor belt surrounded by a pressure resistant explosion protected housing
A conveyor belt scale (1) for transporting and weighing bulk material, having a rocker (6) that acts on a rod system (9), and having a weighing cell (11) connected with the rod system (9), is supposed to be configured in such a manner that the weighing cell, in particular, can also be reached from the outside.This is achieved in that the conveyor belt (2) is surrounded by a pressure-resistant, explosion-protected housing (7), whereby the rod system (9) that acts on the weighing cell (11) is passed out of the housing (7) by way of at least one elastic bearing (10) having a pressure-resistant seal, whereby the weighing cell (11) is positioned outside of the housing (7).
US08610003B2 Shielding plate and shielding assembly with same
A shielding structure includes a frame and a removable plate. The frame includes a peripheral wall, and the removable plate located in the opening may be fixed to the connecting board, the removable plate defining an access hole. A scored line is defined between the removable plate and the connecting board. The shielding structure further defines an arcuate gap between the removable plate and the connecting board and communicating with the scored line, and a mating hole, the arcuate gap is for increasing the shearing stresses on shielding structure the scored line when the removable plate must be removed.
US08610000B2 Circuit board for an electrical connector
A circuit board includes a substrate having upper and lower sides, and first and second conductive vias extending between the upper and lower sides. The first and second conductive vias include circular outer profiles. The circuit board also includes a differential pair of conductive traces, which includes a first conductive trace having first upper and lower segments disposed on the upper and lower sides, respectively. The first upper and lower segments are electrically connected together through the first conductive via. The first upper segment is curved around the second conductive via such that the first upper segment follows the circular outer profile of the second conductive via. The differential pair of conductive traces also includes a second conductive trace having second upper and lower segments disposed on the upper and lower sides, respectively. The second upper and lower segments are electrically connected together through the second conductive via. The first upper segment crosses over the second lower segment. The second lower segment is curved around the first conductive via such that the second lower segment follows the circular outer profile of the first conductive via.
US08609998B2 Wiring board and method of manufacturing the same
A wiring board (package) has a structure in which multiple wiring layers are stacked one on top of another with insulating layers each interposed between corresponding two of the wiring layers, and the wiring layers are connected to one another through vias formed in each of the insulating layers. In a peripheral region of the package, reinforcing patterns are provided on the same surfaces where the corresponding wiring layers are provided, respectively. Each of the reinforcing patterns is formed of a conductive layer formed on the same surface where the corresponding one of the wiring layers is provided, and is provided in an intermittent ring-like shape when viewed in a planar view.
US08609996B2 Printed circuit board and layout method thereof
A printed circuit board includes a signal layer having a pair of differential transmission lines thereon. An eye width and an eye height of an eye diagram obtained at output terminals of the pair of differential transmission lines are variable according to a distance between the pair of differential transmission lines. The eye width and the eye height of the eye diagram are at minimum values when the distance between the pair of differential transmission lines is at a first distance. The eye width and the eye height meet requirements of the pair of differential transmission lines for the eye diagram when the distance between the pair of differential transmission lines is set at a second distance, the second distance is less than the first distance.
US08609995B2 Multilayer wiring board and manufacturing method thereof
Disclosed is a manufacturing method of a multilayer wiring board. The multilayer wiring board includes an outer resin insulation layer made of an insulating resin material, containing a filler of inorganic oxide and having an outer surface defining a chip mounting area to which an electronic chip is mounted with an underfill material filled in between the outer resin insulation layer and the electronic chip and holes through which conductor parts are exposed. The manufacturing method includes a hole forming step of forming the holes in the outer resin insulation layer by laser processing, a desmear treatment step of, after the hole forming step, removing smears from inside the holes of the outer resin insulation layer, and a filler reducing step of, after the desmear treatment step, reducing the amount of the filler exposed at the outer surface of the outer resin insulation layer.
US08609991B2 Flex-rigid wiring board and method for manufacturing the same
A flex-rigid wiring board including a rigid substrate including a rigid base material and a conductor layer, and a flexible substrate having a conductor layer. The conductor layer of the flexible substrate is electrically connected to the conductor layer of the rigid substrate. The rigid substrate has a recessed portion which is formed on a surface of the rigid substrate and which accommodates an electronic component.
US08609989B2 Electrical cable and method and device for the manufacture thereof
An electrical cable including an inner conductor arrangement having a longitudinally extended conductor. The electrical cable further including an outer sheath that surrounds the inner conductor arrangement annularly in cross-section, and an electrical shield that extends between the inner conductor arrangement and the outer sheath, wherein a portion of the electrical shield is turned inside out in such a way that it is spaced apart from a main area of the electrical shield. The portion defines an inside-out portion and extends between the inner conductor arrangement and the outer sheath transversely to a direction in which the electrical cable extends. In addition, an exterior region of the inside-out portion of the electrical shield is incorporated in at least some portions into the sheath of the electrical cable.
US08609987B2 High voltage direct current cable termination apparatus
A direct current cable termination apparatus for terminating a high voltage direct current cable, the apparatus includes a current-carrying device including a terminal portion of the direct current cable, the cable at least including an electrical conductor, a electrically insulating layer located outside of the electrical conductor, and a conductive shield located outside of the insulating layer and the electrical conductor. The apparatus includes a housing including a tubular outer shell with an inner periphery, the outer shell defining a longitudinal axis and being formed by an electrically insulating and polymer-containing material. The current-carrying device extends in the axial direction of the outer shell. Along at least a part of the axial extension of the current-carrying device the outer shell extends axially with a space between its inner periphery and the current-carrying device. The housing is adapted to separate the space from an atmosphere outside the outer shell.
US08609985B2 Electronic device housing and manufacturing method
An electronic device housing is disclosed. The electronic device housing, the electronic device housing comprises a cover comprising a base board, a receiving portion defined in the base board, and a fixing portion in the receiving portion; a silicone rubber membrane; and a panel received in the receiving portion, the panel is fixed to the cover via the silicone rubber membrane.
US08609983B2 Interconnection sheet, solar cell with interconnection sheet, solar cell module, and interconnection sheet roll
An interconnection sheet, a solar cell with the interconnection sheet, a solar cell module, an interconnection sheet roll, a solar cell with an interconnection sheet and solar cell module satisfy a relationship of Y≦Z
US08609975B2 Electronic devices including transparent conductive coatings including carbon nanotubes and nanowire composites, and methods of making the same
Certain example embodiments of this invention relate to large-area transparent conductive coatings (TCCs) including carbon nanotubes (CNTs) and nanowire composites, and methods of making the same. The σdc/σopt ratio of such thim films may be improved via stable chemical doping and/or alloying of CNT-based films. The doping and/or alloying may be implemented in a large area coating system, e.g., on glass and/or other substrates. In certain example embodiments, a CNT film may be deposited and then doped via chemical functionalization and/or alloyed with silver and/or palladium. Both p-type and n-type dopants may be used in different embodiments of this invention. In certain example embodiments, silver and/or other nanowires may be provided, e.g., to further decrease sheet resistance. Certain example embodiments may provide coatings that approach, meet, or exceed 90% visible transmission and 90 ohms/square target metrics.
US08609974B2 Solar to electrical energy conversion using the streaming potential
A system and method is presented that uses solar power driven expansion of an electrolytic solution to force the electrolytic solution from a container through at least one pore of an insulator having a fixed surface charge of one polarity into a collection receptacle. The velocities of the cations and anions flowing through the pore differ because of the fixed surface charge of the pore and this produces an electrical charge separation, the streaming potential, as a source of electrical power. Energy absorption spans the full solar spectrum including infrared, visible and near ultraviolet wavelengths.
US08609966B2 Transposable capo system and method
A transposable capo system for a stringed musical instrument includes at least one magnetic capo stud having a string slot adapted to receive a string on the instrument.
US08609964B2 Plants and seeds of hybrid corn variety CH738196
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH738196. The invention thus relates to the plants, seeds and tissue cultures of the variety CH738196, and to methods for producing a corn plant produced by crossing a corn plant of variety CH738196 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH738196.
US08609953B2 Soybean seed and oil compositions and methods of making same
Methods for obtaining soybean plants that produce seed with low linolenic acid levels and moderately increased oleic levels are disclosed. Also disclosed are methods for producing seed with low linolenic acid levels, moderately increased oleic levels and low saturated fatty acid levels. These methods entail the combination of transgenes that provide moderate oleic acid levels with soybean germplasm that contains mutations in soybean genes that confer low linolenic acid phenotypes. These methods also entail the combination of transgenes that provide both moderate oleic acid levels and low saturated fat levels with soybean germplasm that contains mutations in soybean genes that confer low linolenic acid phenotypes. Soybean plants and seeds produced by these methods are also disclosed.
US08609945B1 Soybean variety XB33H12
A novel soybean variety, designated XB33H12 is provided. Also provided are the seeds of soybean variety XB33H12, cells from soybean variety XB33H12, plants of soybean XB33H12, and plant parts of soybean variety XB33H12. Methods provided include producing a soybean plant by crossing soybean variety XB33H12 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB33H12, methods for producing other soybean varieties or plant parts derived from soybean variety XB33H12, and methods of characterizing soybean variety XB33H12. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB33H12 are further provided.
US08609940B1 Soybean cultivar GO0810002
The present invention is in the field of soybean variety GO0810002 breeding and development. The present invention particularly relates to the soybean variety GO0810002 and its progeny, and methods of making GO0810002.
US08609936B2 Hemipteran-and coleopteran active toxin proteins from Bacillus thuringiensis
A novel Bacillus thuringiensis crystal protein exhibiting insect inhibitory activity is disclosed. Growth of Lygus insects is significantly inhibited by providing the novel crystal protein in Lygus insect diet. Polynucleotides encoding the crystal protein, transgenic plants and microorganisms that contain the polynucleotides, isolated peptides derived from the crystal protein, and antibodies directed against the crystal protein are also provided. Methods of using the crystal protein and polynucleotides encoding the crystal protein to control Hemipteran insects are also disclosed.
US08609934B2 In vivo assembly of transcription units
Methods of providing gene suppression DNA in a eukaryotic organism comprising introducing a first DNA segment and at least one second DNA segment into the genome of the organism. One of the DNA segments contains a promoter and a transcribable DNA. Another DNA segment contains at least part of the transcribable DNA. When inserted in tandem, the DNA segments are assembled in vivo forming a recombinant transcription unit. RNA transcribed from the transcription unit can form double-stranded RNA.
US08609929B1 Maize hybrid X08B730
A novel maize variety designated X08B730 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X08B730 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X08B730 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X08B730, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X08B730. This invention further relates to methods for producing maize varieties derived from maize variety X08B730.
US08609926B1 Methods for managing sulfide in wastewater systems
Certain exemplary embodiments can provide a system, machine, device, manufacture, circuit, composition, and/or user interface adapted for and/or resulting from, and/or a method and/or machine-readable medium comprising machine-implementable instructions for, activities that can comprise and/or relate to, in a treatment zone, reacting an oxygen-comprising gas, one or more selected ferric/ferrous chelates, one or more selected nitrates and/or nitrites, and/or anaerobic wastewater.
US08609925B2 Adsorbents with improved mass transfer properties and their use in the adsorptive separation of para-xylene
Adsorbents and methods for the adsorptive separation of para-xylene from a mixture containing at least one other C8 aromatic hydrocarbon (e.g., a mixture of ortho-xylene, meta-xylene, para-xylene, and ethylbenzene) are described. Suitable adsorbents comprise zeolite X having an average crystallite size of less than 1.8 microns. The adsorbents provide improved mass transfer, which is especially advantageous for improving productivity in low temperature, low cycle time adsorptive separation operations in a simulated moving bed mode.
US08609922B2 Energy conservation in heavy-hydrocarbon distillation
An aromatics complex producing one or more xylene isomers offers a large number of opportunities to conserve energy by heat exchange within the complex. One previously unrecognized opportunity is through providing two parallel distillation columns operating at different pressures to separate C8 aromatics from C9+ aromatics. The parallel columns offer additional opportunities to conserve energy within the complex through heat exchange in associated xylene recovery facilities.
US08609906B2 Process for preparing C1-C4-oxygenates by partial oxidation of hydrocarbons
A process for preparing C1-C4-oxygenates from a reactant stream A which comprises essentially a C1-C4-alkane or a mixture of C1-C4-alkanes, by a) branching off a substream B of the reactant stream A and allowing it to react in a reactor with oxygen or an oxygenous gas stream C, which converts a portion of the C1-C4-alkane or a portion of the mixture which comprises C1-C4-alkanes to C1-C4-oxygenates, b) removing at least 90 mol % of the C1-C4-oxygenates formed from the product stream D resulting from step a) to form a remaining low boiler stream E, which comprises combining the low boiler stream E with the reactant stream A without further workup and without combination with the substream B down-stream of the branching site of the substream B.
US08609905B2 Method for producing glycerol
The present invention provides a method for producing glycerol, including transesterifying an oil-and-fat with an alcohol in the presence of a solid catalyst to obtain a glycerol product liquid and subjecting the glycerol product liquid to adsorption treatment with an ion-exchange resin.
US08609900B2 Dendritic macromolecule and a process thereof
The present invention is in relation to a dendritic molecule having symmetrically sited branches having four or more generations of dendrimers wherein the branch points are tertiary amines linked together with oxygen atom of ether and the heteroatoms are separated by a substituted or non-substituted linear three methylene linker. In addition the invention also provides a process to prepare such dendritic macromolecules.
US08609896B2 Ferric organic compounds, uses thereof and methods of making same
The present invention discloses a novel form of ferric organic compounds, including a form of ferric citrate, which are soluble over a wider range of pH, and which have a large active surface area. The ferric organic compounds of the present invention can be delivered effectively by oral route with better delivery to treat patients suffering from hyperphosphatemia, metabolic acidosis and other disorders responsive to ferric organic compound therapy.
US08609890B1 Cyclic process for the production of taurine
A method is disclosed for the production of taurine by a cyclic process of reacting ethylene oxide with sodium bisulfite and ammonium to obtain sodium taurinate. After excess ammonia is removed from the reaction mixture, sodium taurinate is neutralized with sulfur dioxide or sulfurous acid to recover taurine and to regenerate sodium bisulfate, which is then reacted with ethylene oxide.
US08609889B2 Photoacid generator, resist composition, and patterning process
The photoacid generator produces a sulfonic acid which has a bulky cyclic structure in the sulfonate moiety and a straight-chain hydrocarbon group and thus shows a controlled acid diffusion behavior and an adequate mobility. The PAG is fully compatible with a resin to form a resist composition which performs well during the device fabrication process and solves the problems of resolution, LWR, and exposure latitude.
US08609885B2 Synthesis of methylene malonates substantially free of impurities
The present invention provides improved methods for the chemical synthesis of methylene malonates using the Knovenagel synthesis reaction. The method of the invention provides for improved methylene malonates by significantly reducing or eliminating the formation of alternative and/or deleterious side products, significantly reducing or eliminating unwanted consumption of methylene malonates, and significantly reducing or eliminating the degradation of methylene malonates. These advantages result in methylene malonates, which upon recovery, are of higher quality, greater purity, improved yield and possess overall improved performance characteristics (e.g., improved cure speed, retention of cure speed, improved shelf-life and/or stability).
US08609883B2 Continuous method for producing acyl peroxides
The invention relates to a continuous method for producing acyl peroxides. According to said method, an acyl chloride, carboxylic acid anhydride or chloroformate is reacted with an organic hydroperoxide or hydrogen peroxide in at least two mixed reaction zones that are connected in series, the acyl compound, the peroxy compound and an aqueous solution of a base being supplied to the first reaction zone. The first reaction zone comprises a cycle for the two-phase reaction mixture via a heat exchanger in which the reaction mixture is cooled. The method allows the reaction to be carried out reliably and with high space-time yields.
US08609882B2 Process for deacetalisation of α aminoacetals
The invention relates to a process for the preparation of N-protected α-aminoaldehydes by deacetalization of the acetal functional group of corresponding N-protected α-aminoacetals using formic acid.
US08609878B2 Method for producing 6-chlorodibenzo[D,F] [1 3,2]Dioxaphosphepin
The invention relates to a method for producing 6-chlorodibenzo[d,f][1,3,2]-dioxaphosphepin (formula 1), comprising the following steps: a) addition of liquid 2,2′-dihydroxybiphenyl into a reactor to an excess of phosphorous trichloride under inert gas and stirring; b) discharge and neutralization of the resulting gases from the reaction mixture; c) separation of the excess phosphorous trichloride; d) obtention of 6-chlorodibenzo[d,f][1,3,2]-dioxaphosphepin.
US08609877B2 Cyclic diol-derived blocked mercaptofunctional silane compositions
Diol derived blocked mercaptofunctional silane compositions in which the silanes comprise cyclic and bridged alkoxy groups derived from hydrocarbon-based diols and processes for their preparation are provided. Also provided are rubber compositions comprising the cyclic diol-derived blocked mercaptofunctional silanes, processes for their preparation and articles of manufacture comprising the rubber compositions, in particular, automotive tires and components thereof.
US08609874B2 Recovery of desired co-products from fermentation stillage streams
Processes and methods of recovering desired products from fermentation stillage are presented, including processes and methods of recovering lipids and aqueous materials.
US08609873B2 Process for making and using HOF.RCN
The invention relates to a process for making HOF.RCN and using it to oxidise organic substrates in a quick and safe way. The process comprises passing diluted fluorine through a conduit and RCN in water through another conduit into a microreactor to form HOF.RCN and reacting this with an organic substrates.
US08609869B2 Heteroaromatic-containing compound, optical material and optical element
There are provided a heteroaromatic-containing compound represented by the following general formula (1), and an optical material including the heteroaromatic-containing compound. wherein R1 and R2 are each independently a hydrogen atom or a methyl group, Ar1 is an aryl group which may have a substituent, and A is an aromatic hydrocarbon group. The R1 and R2 can be a hydrogen atom, and Ar1 can be a phenyl group.
US08609867B2 Substituted indolocarbazoles
A substituted indolocarbazole comprising at least one optionally substituted thienyl.
US08609862B2 Use of an adrenal hormone-modifying agent
The present invention relates to a method of treating a disease or disorder characterised by increased stress hormone levels and/or decreased androgen hormone levels in a subject, comprising administering to the subject a therapeutically effective amount of a compound represented by formula (I): wherein n is 1 or 3; R is hydrogen or —C(O)N(Ra)(Rb) wherein Ra and Rb are independently —(C1-C4)alkyl, or —(C1-C4)alkyl-(C5-C7)aryl, wherein each of Ra and Rb is optionally substituted by —(C1-C4)alkoxy; R1, R2, and R3, are independently hydrogen, halogen, cyano or —(C6-C10) aryl, wherein said —(C6-C10)aryl is optionally substituted by halogen, with the proviso that no more than one of R1, R2, and R3 is hydrogen; and R4 and R5 are hydrogen; or a pharmaceutically acceptable salt thereof.
US08609859B2 One pot process for preparing 2-butyl-3-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro [4, 4] non-1-en-4-one (irbesartan)
A one pot process for the synthesis of Irbesartan comprising reacting 2-n-Butyl-1,3-Diazaspiro[4,4]Non-1-en-4-one (Formula III) and Bromomethyl Cyanobiphenyl (Formula IV) in the presence of base and water with the optional use of PTC to give formula II from which Irbesartan is obtained by reacting with sodium azide and triethylamine hydrochloride in the presence of a non polar solvent.
US08609856B2 Crystalline forms of Febuxostat
New forms of Febuxostat have been prepared and characterized. These forms are useful, for example, in the chronic management of hyperuricemia in patients with gout.
US08609854B2 Process for the preparation of sorafenib tosylate
The present invention provides a process for the preparation of sorafenib tosylate, comprising contacting sorafenib free base with p-toluenesulphonic acid in water.
US08609847B2 Dihydroquinolinone derivatives
The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A dihydroquinolinone derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein Q represents the following formula (A) or (B)}
US08609844B2 Method for extracting and purifying bisbenzylisoquinolines
A method for purifying extracted crude d-tetrandrine by dissolving the crude d-tetrandrine powder in ethanol, treating the solution with a decolorizing agent, filtering, reducing the filtered solution under heat and vacuum, cooling the solution, filtering it and drying the filtered cake to yield substantially pure d-tetrandrine.
US08609836B2 4-aryl-2-anilino-pyrimidines
The present invention relates to compounds of Formula (Ia) or (Ib), the N-oxide forms, pharmaceutically acceptable addition salts, quaternary amines, stereoisomers, tautomers, racemics, metabolites, prodrugs, hydrates, or solvates thereof, wherein Y1, m, n, R1; X1; X2; R2; X3; X4; R3; and R4 have the meaning defined in the claims. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to compounds that are kinase inhibitors useful for the treatment of disease states mediated by kinase, especially PLK4, in particular such compounds that are useful in the treatment of pathological processes which involve an aberrant cellular proliferation, such as tumor growth, rheumatoid arthritis, restenosis and atherosclerosis.
US08609833B2 Purine derivatives as adenosine A1 receptor agonists and methods of use thereof
The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.
US08609831B2 RNA-mediated gene modulation
An isolated RNA comprising an intron RNA that is released in a cell, thereby modulating the function of a target gene. Also disclosed are a composition comprising a chemokine and an isolated RNA of the invention or a DNA template for the isolated RNA, a composition comprising one or more agents that induce RNA-mediated modulation of the functions of two or more target genes in a cell, and methods of using these compositions for modulating the functions of genes in a cell.
US08609824B2 Methods of treatment using thymus-derived compositions
Embodiments of the present invention provide processes for preparing thymus extracts and plant or fungal extracts, and more particularly provide compositions (Thyex-1-6A and -6B) produced in accordance with said processes, and methods for treatment of various conditions comprising administration of said compositions including but not limited to impaired physical vigor or aptitude, and aging and/or age-related conditions (arthritis, mobility deficits, loss of appetite, etc.). Additional aspects provide methods for building muscle mass, for reducing exercise recovery period, or for sustaining exercise intensity. Particular aspects relate to preparation of Houttuynia cordata extracts and the use of those extracts as an anti-emetic and/or anti-nausea treatment for a subject in need thereof.
US08609820B2 Humanized antibodies that recognize alpha-synuclein
The present application discloses humanized 9E4 antibodies. The antibodies bind to human alpha synuclein and can be used for immunotherapy of Lewy body disease.
US08609813B2 Prodrug anti-cancer therapy
Compositions and methods for inhibiting the growth of cancer cells are provided. The cancer cells, the growth of which is inhibited, have constitutively active Abl tyrosine kinase activity due to a t(9;22)(q34;q11) translocation which results in expression of a chimeric Bcr-Abl protein which has constitutively active Abl tyrosine kinase activity that is believed to play an important role in leukemogenesis. The compositions include a modified protein kinase C(PKC) which has an Abl tyrosine kinase target motif. The methods involve administering the modified PCK to an individual to inhibit the growth of cancer cells that have Abl tyrosine kinase activity.
US08609812B2 Use of β-2-microglobulin to assess glomerular alterations and damage in the kidney
The present invention is directed, in part, to a method of measuring β-2-microglobulin to assess glomerular alteration or damage of the kidney.
US08609810B2 Methylglyoxal-scavenging compounds and their use for the prevention and treatment of pain and/or hyperalgesia
The present invention relates to compounds which inhibit or antagonize the binding of methylglyoxal (MG) and/or other reactive carbonyl species (RCS) to an arginine- or lysine- containing protein, preferably an arginine- or lysine-containing cellular protein, such as a sodium ion channel, e.g. the sodium ion channel Na(v)1.8. Preferred scavenger compounds are peptides comprising several or multiple repeats of the amino acid sequence motif Gly-Glu-X-Pro (GEXP), wherein X is Arg or Lys, and pharmaceutical compositions thereof. The present invention furthermore relates to the use of the compounds as scavenger or antagonists of methylglyoxal and/or related reactive carbonyl species (RCS). The present invention furthermore relates to the use of the compounds for the prevention and/or treatment of pain, hyperalgesia and pain related diseases, in particular pain and/or hyperalgesia caused by or associated with methylglyoxal and/or reactive carbonyl species (RCS).
US08609809B2 Bis-sulfhydryl macrocyclization systems
Novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production are provided.
US08609807B2 Method of producing low-dust granules from polymer additives
The invention relates to a technically advantageous method of producing low-dust granules of polymer additives or polymer additive mixtures. The granule-forming polymer additives are mixed together, the mixture is converted into a workable mass and pressed through an orifice. The pre-shaped strand-like extruded mass is cooled and, while still in a workable state, formed into granules by rolling, impressing, cooling and comminuting.
US08609798B2 Process for preparing polydimethylsiloxanes on sulphonic acid cation exchange resins
The invention relates to a process for the targeted reorganization of polydimethylsiloxanes over sulphonic acid-containing cation exchange resins which have water contents of 8 to 25% by weight, and polydimethylsiloxanes thus prepared and the use thereof.
US08609797B2 Room temperature vulcanizable polymers
A room-temperature vulanizable (RTV) polymeric composition comprising organosiloxane or polyurethane units having at least one terminal methyl isopropyl ketoximino or methyl propyl ketoximino moiety, as well as methods of making the same.
US08609791B2 Method for replacing compatible ethylene polymerization catalysts
The present invention relates to a method for optimizing the sequential feeding of at least two ethylene polymerization catalysts to an ethylene polymerization reactor, comprising: transferring to a mixing vessel a first ethylene polymerization catalyst and a first diluent, decreasing the concentration of said first ethylene polymerization catalyst in said mixing vessel, transferring to said mixing vessel a second ethylene polymerization catalyst and a second diluent, progressively replacing said first ethylene polymerization catalyst by said second ethylene polymerization catalyst and said first diluent by said second diluent, increasing the concentration of said second ethylene polymerization catalyst in said mixing vessel, sequentially transferring said first ethylene polymerization catalyst and said second ethylene polymerization catalyst from said mixing vessel to an ethylene polymerization reactor.
US08609789B2 Oligomeric and polymeric aromatic phosphonic acids, their blends, processes for preparing them and uses as polyelectrolytes
The present invention relates to halogen-free, oligomeric or polymeric phosphonic acids made up of units of the general formula (I) —[(O)m—{R1(X)n(Y)o}pR1(X)q]r—[(O)s—R5(X)t]v—  (I), where: Xis —P═O(OH)2, Yis carbonyl or sulfonyl, R1, R5are, independently of one another, divalent or polyvalent, substituted or unsubstituted, heteroatom-free or heteroatom- comprising aromatic radicals, m, o, sare each, independently of one another, 0 or 1, n, q, tare each, independently of one another, 0 or an integer from 1 to 8, with n and s not simultaneously being 0, r, vare each, independently of one another, from 0 to 1, with the sum of r and v being from 0.95 to 1.05, and pis 0 or an integer ≧1, where the radicals X are substituents on R1 and R5 and the radicals Y are parts of polymer or oligomer chain, to a process for preparing these compounds and also to halogen-free mixtures comprising one or more compounds of the general formula (I) and a nitrogen-free solvent having a boiling point of >150° C.
US08609785B2 Modified polyamide composition containing at least one phenolic compound
The use of a phenolic compound for producing a modified polyamide having enhanced mechanical properties is described. A polyamide composition including at least such phenolic compound and optionally reinforcing or filler loads is also described. The composition is preferably a composition for molding, for example in the form of granules or powder, that can be used for the production of articles by injection-molding.
US08609779B2 Functionalized ethylene/alpha-olefin interpolymer compositions
The invention relates to functionalized interpolymers derived from base olefin interpolymers, which are prepared by polymerizing one or more monomers or mixtures of monomers, such as ethylene and one or more comonomers, to form an interpolymer products having unique physical properties. The functionalized olefin interpolymers contain two or more differing regions or segments (blocks), resulting in unique processing and physical properties.
US08609778B1 Styrenic resin incorporating recycled polystyrene
The present disclosure provides a styrenic resin incorporating post-consumer recycle polystyrene (PCR PS), and systems and methods for making the same. For example, a styrenic resin produced in accordance with present embodiments includes at least approximately 20 weight percent PCR PS, has a melt flow rate (MFR) of less than approximately 2.5 g/10 min per ASTM D-1238-10, and an Mz+1 molecular weight of at least 685,000. The styrenic resin is produced by a free-radical polymerization process performed on a feed having PCR PS dissolved in monovinylarene monomer. The feed is produced in such a way so as to remove contaminants commonly associated with PCR PS.
US08609775B2 Electrode with reduced mud cracking via mixed equivalent weight ionomers
An ink composition for forming a fuel cell electrode, and in particular, a fuel cell cathode layer is provided. The ink composition includes a first protogenic group-containing ionomer having an equivalent weight less than 800, an optional second protogenic group-containing ionomer having an equivalent weight greater than 800, and a catalyst composition. Electrode layers formed from the ink composition are also provided.
US08609773B2 Olefin/acrylic polymer blends
In one aspect of the present invention, there is provided a polymeric film comprising one or more polyolefins and one or more acrylic polymers, wherein the weight ratio of said acrylic polymers to said polyolefins is from 0.02:1 to 5:1, wherein each said polyolefin comprises polymerized units of one or more functional monomers, wherein the amount of said polyolefins in said polymeric film is more than 30% by weight, based on the weight of said polymeric film, and wherein said acrylic polymers comprise polymerized units of one or more hydrogen-bondable monomers.
US08609771B2 Process for preparing a vinylidene chloride polymer composition
Process for preparing a composition of a vinylidene chloride polymer and at least one ε-caprolactone polymer according to which: a) during the preparation of the vinylidene chloride polymer by polymerization of the vinylidene chloride and at least one comonomer that is copolymerizable with it, at least one ε-caprolactone polymer, preformed in a medium other than that of the vinylidene chloride polymerization, is added; and b) optionally, in addition, at least one ε-caprolactone polymer is added to the vinylidene chloride polymer isolated at the end of step a). Process for preparing articles, in particular films, which includes the use of a composition prepared by the aforementioned process. Single-layer or multilayer film comprising said composition and packaging or bag formed from this film.
US08609770B2 Polyesters modified by a combination of ionomer and organic acid salts
Disclosed is a thermoplastic composition comprising a poly(trimethylene terephthalate) and about 0.2 to about 30 weight % of a modifier comprising organic acid and an ionomer derived from an ethylene acid copolymer in which the combined acid moieties of the organic acid and acid copolymer are at least partially neutralized with cations of magnesium, calcium, zinc, or a combination thereof.
US08609766B2 Polymer compositions
The invention provides a composition comprising at least the following: A) a thermoplastic polyurethane; B) an elastomer; C) a polydiene-based polyurethane or a polydiol-based polyurethane; D) a polyoctenamer; and E) a resin selected from the group consisting of the following: i) an indene-coumarone resin, ii) an aromatic hydrocarbon resin, and iii) an aliphatically modified aromatic hydrocarbon resin.
US08609764B2 Polarizer having excellent durability, polarizing plate and methods of producing the polarizer and the polarizing plate
There is provided a method of producing a polyvinyl alcohol (PVA) film polarizer having an excellent durability, the method comprising dyeing, cross-linking, stretching, and drying, wherein additives containing phosphorus is inputted into one or more of the dyeing, the cross-linking, and the stretching. In this case, the additives containing phosphorus may be selected from a group consisting of a phosphoric acid, potassium phosphate monobasic, potassium phosphate dibasic, magnesium phosphate dibasic, sodium phosphate monobasic, and ammonium phosphate monobasic. An amount of the additives containing phosphorus in an added solution may be 0.01 to 15 wt %. As described above, when inputting the additives containing phosphorus while producing a polarizer, cross-linking between iodine and a polymer matrix becomes strong due to the phosphorus contained in the additives, thereby producing a polarizer having an excellent durability, and particularly, an excellent thermal stability.
US08609762B2 Aqueous coating compositions containing acetoacetyl-functional polymers, coatings, and methods
An aqueous coating composition containing (i) a polymer having one or more acetoacetyl-functional groups; and (ii) an acid-functional polymer, which may be the same as or distinct from the polymer comprising acetoacetyl-functional groups, wherein a nitrogen-free base has been used to neutralize or partially neutralize the acid-functionality on the polymer.
US08609761B1 Modified acrylic polymer coating and method
The coating includes components water, styrene acrylic polymer, refined white dolomite, processed granite, calcium sulfate, silicon concentrate 10 percent, titanium dioxide, triton x-100, butoxyethanol and light mineral spirits. Also included is the method of mixing and preparing the coating.
US08609759B2 Coating composition with high pigment volume content opaque polymer
The present invention relates to a latex composition comprising a) an opaque polymer having a pigment volume concentration of from 18 to 28; b) fully or partially polymer encapsulated TiO2 particles having a pigment volume concentration of from 8 to 18; c) an extender having a pigment volume concentration of from 0 to 10; d) a binder; e) a thickener; and f) water. Notwithstanding the surprisingly high pigment volume concentration of opaque polymer, the composition—upon application to a substrate—gives a coating with a gloss or semi-gloss finish, excellent hiding, and acceptable burnish resistance.
US08609757B2 Cationic cross-linked polymers in water-in-water polymer dispersions
The invention relates to water-in-water polymer dispersions containing cross-linked cationic polymers, methods for their preparation and their use. The water-in-water polymer dispersions are useful inter alia as flocculants, dewatering (drainage) aids and retention aids in papermaking.
US08609755B2 Storage stable composition of partial and/or complete condensate of hydrolyzable organofunctional silane
Conversion and passivation coatings and methods for treating metal surfaces such as steel and aluminum are disclosed. The coating compositions comprise a silane and a stabilizing agent. The methods herein comprise contacting the requisite metal surface with the coating composition.
US08609754B2 Flame-retardant thermoplastic resin composition and molded article thereof
Provided is a flame-retardant thermoplastic resin composition in which any halogenated flame retardant is not used but a phosphoric flame retardant is used, which has flame retardancy meeting U.S. UL Standard 94 V-2, which exhibits excellent dripping performance during burning, and which is excellent in balance between properties. The flame-retardant thermoplastic resin composition contains 100 parts by mass of a copolymer mixture containing a graft copolymer (A) obtained by graft-polymerizing a rubbery polymer, a vinyl cyanide compound, and a copolymerizable vinyl compound and a vinyl copolymer (B) which is obtained by copolymerizing the vinyl cyanide compound and the copolymerizable vinyl compound and which has a mass-average molecular weight of 90,000 to 160,000 and 5 to 20 parts by mass of a phosphoric flame retardant (C) blended with the copolymer mixture. The content CB1 of vinyl cyanide units in the acetone-insoluble fraction of the copolymer mixture is 22.0% to 32.0% by mass, the content CB2 of vinyl cyanide units in the acetone-soluble fraction thereof is 22.0% to 34.0% by mass, and |CB1−CB2| is 0% to 3.0% by mass.
US08609752B2 Asphaltenes-based polymer nano-composites
Inventive composite materials are provided. The composite is preferably a nano-composite, and comprises an asphaltene, or a mixture of asphaltenes, blended with a polymer. The polymer can be any polymer in need of altered properties, including those selected from the group consisting of epoxies, acrylics, urethanes, silicones, cyanoacrylates, vulcanized rubber, phenol-formaldehyde, melamine-formaldehyde, urea-formaldehyde, imides, esters, cyanate esters, allyl resins.
US08609747B2 Aqueous pigment dispersion and aqueous ink for ink jet recording
[Problem] To provide an aqueous ink for inkjet recording, which realizes excellent ink ejection properties, tinctorial strength, and image fastness.[Means for Resolution] An ink containing a pigment dispersion containing A and B, and an aqueous medium: A: an azo pigment represented by the following formula (1) and having at least one characteristic peak at Bragg angles (2θ) of 5 to 15° and 20 to 30° in X-ray diffraction with characteristic Cu Kα line; and B: a vinyl polymer containing a hydrophobic structural unit (a) and a hydrophilic structural unit (c).
US08609745B2 Production of ophthalmic devices based on photo-induced step growth polymerization
The invention provide a new lens curing method for making hydrogel contact lenses. The new lens curing method is based on actinically-induced step-growth polymerization. The invention also provides hydrogel contact lenses prepared from the method of the invention and fluid compositions for making hydrogel contact lenses based on the new lens curing method. In addition, the invention provide prepolymers capable of undergoing actinically-induced step-growth polymerization to form hydrogel contact lenses.
US08609742B2 High energy ray-curable composition
Disclosed is a high energy ray-curable composition which is excellent in storage stability before curing and enables to form a cured coating film which is excellent in hardness, property of preventing adhesion of fats and oils, property of wiping off fats and oils, abrasion resistance, transparency, water repellency, adhesion, smoothness and uniformity. Specifically disclosed is a high energy ray-curable composition containing the following components (A)-(D). (A) 100 parts by weight of a polyfunctional acrylate (B) 1-30 parts by weight of an organoalkoxysilane having an aliphatic unsaturated bond (C) 1-100 parts by weight of colloidal silica (D) 0.2-20 parts by weight of a fluorine compound having an aliphatic unsaturated bond.
US08609740B2 Closed-loop recycled polyurethane foam, methods of manufacture and products therefrom
The present disclosure relates to the production of molded products containing recycled content, and more particularly polyurethane foam which includes polyol recovered from chemical recycling of polyurethane foam scrap, which polyol has been treated to optimize viscosity and/or reactivity characteristics.
US08609739B2 Poly(perfluorocyclobutane) ionomer with phosphonic acid groups for high temperature fuel cells
A polymer for ion conductor applications includes a polymer segment having a perfluorocyclobutyl moiety and a phosphonated aryl group and a polymer segment a perfluorocyclobutyl moiety without phosphonated aryl group. The polymer is formed into an ion conducting membrane for fuel cell applications.
US08609737B2 Process for preparing monodispersed emulsions
A process for preparing an emulsion is disclosed comprising: injecting a first liquid as dispersed phase liquid through a central inlet of a microchannel system with a cross junction geometry chip and injecting a second liquid as continuous phase liquid through the outer cross inlet, which continuous phase liquid does not instantly mix with said injected first liquid prior to the cross junction, wherein the flow rate QC of the continuous phase in cubic meters per second is given by Q C = f × A ⁢ ⁢ γ μ d , where A is the exit area of the microchannel in square meters, γ the interfacial tension between the first liquid and the second liquid in Newtons per meter and μd the viscosity of the dispersed phase in Pascal-seconds, characterized in that f is in the range from 0.04 to 0.25.
US08609736B2 Telomerase activating compounds and methods of use thereof
The present invention is directed to use of a series of compounds and compositions comprising the same for activating telomerase and treating diseases, disorders and/or conditions related thereto.
US08609733B2 Sensory-specific local anesthesia and prolonged duration local anesthesia
Combinations of charged local anesthetics with chemical permeation enhancers have been developed to give long duration block which is selective for sensory block over motor block. The duration of block is greatly prolonged by combining the local anesthetic with a permeation enhancer. The selectivity of sensory over motor block is provided by selecting the concentration of the local anesthetic and the permeation enhancer to provide selective permeability of the sensory and motor neurons to the enhancer.
US08609728B2 Treatment for pulmonary hypertension
One embodiment relates to a method of treating pulmonary hypertension based upon co-administering to a subject in need thereof a pharmaceutically effective amount of an oral therapeutic agent for treating pulmonary hypertension and a pharmaceutically effective amount of an inhaled therapeutic agent for treating pulmonary hypertension. The benefit of the co-administration of these agents is to eliminate or reduce one or more side effects associated with mono-therapy of either agent, as well as one or more side effects associated with other administration routes such as subcutaneous or intravenous administration.
US08609720B2 Compounds for treating proliferative disorders
Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.
US08609714B2 Thiophene compounds for liquid-crystalline media
The invention relates to liquid-crystalline compounds of the formula I in which R1, R2, A1, A2, A3, A4, Z1, Z2, Z3, V, a, b and c have the meanings indicated in Claim 1, and to liquid-crystalline media comprising at least one compound of the formula I, and to electro-optical displays containing a liquid-crystalline medium of this type.
US08609712B2 Purification of progesterone receptor modulators
Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
US08609710B2 Cycloalkyl-substituted imidazole derivative
A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein A represents a C3 to C12 cycloalkyl group which may be substituted by one to three selected from a fluoro group, a hydroxy group, a C1 to C6 alkyl group, etc; R1, R2, and R3 each independently represent a hydrogen atom, a fluoro group, or a C1 to C6 alkyl group; R4 represents a hydrogen atom or a prodrug group; and Y represents —CH2—CHR5—CH2—NHR6 (wherein R5 represents a hydrogen atom, a C1 to C6 alkyl group, or a C1 to C6 alkoxy group, and R6 represents a hydrogen atom or a prodrug group), or the like exhibits excellent TAFIa inhibitory activity and is useful as a therapeutic drug for myocardial infarction, angina pectoris, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, and the like.
US08609708B2 Synthetic compounds and derivatives as modulators of smoking or nicotine ingestion and lung cancer
Disclosed are nicotine-related compounds that selectively inhibit cytochrome P-450 2A6 (CYP2A6), selectively inhibit cytochrome P-450 2A13 (CYP2A13), and/or selectively modulate a nicotinic acetylcholine receptor (nAChR). Also disclosed are pharmaceutical compositions comprising a compound of the invention, as well as methods of using the pharmaceutical compositions for treating or preventing a disease or disorder associated with nicotine-ingestion, or a disease or disorder amenable to treatment by selective modulation of nAChRs.
US08609707B2 Formulations of bendamustine
Long term storage stable bendamustine-containing compositions are disclosed. The compositions can include bendamustine or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable fluid which can include in some embodiments PEG, PG or mixtures thereof and an antioxidant or chloride ion source. The bendamustine-containing compositions have less than about 5% total impurities, on a normalized peak area response (“PAR”) basis as determined by high performance liquid chromatography (“HPLC”) at a wavelength of 223 nm, after at least about 15 months of storage at a temperature of from about 5° C. to about 25° C.
US08609705B2 Fused heterocyclic compounds, and compositions thereof, for use in arthropod pest control
Disclosed is a harmful arthropod control composition comprising, as an active ingredient, a fused heterocyclic compound represented by formula (1) [wherein A1 and A2 independently represent a nitrogen atom or the like; R1 and R4 independently represent a halogen atom or the like; R2 and R3 independently represent a halogen atom or the like; R5 and R6 independently represent a linear C1-C6 hydrocarbon group which may be substituted, or the like (provided that both R5 and R6 cannot represent a hydrogen atom simultaneously); and n represents 0 or 1]. The harmful arthropod control composition has an excellent efficacy to control harmful arthropods.
US08609704B2 Method for reducing odor in personal care products
A personal care composition which contains 25-200 ppm of 2-methyl-4-isothiazolin-3-one and at least one hydroquinone radical scavenger, and a method for reducing odor arising in personal care compositions containing 2-methyl-4-isothiazolin-3-one.
US08609699B2 Oxotetrahydrofuran-2-yl-benzimidazole derivative
The present invention relates to compounds, which are useful for treatment and/or prevention of diabetes mellitus, diabetes mellitus complications or obesity, since the compounds have glucokinase-activating effects, and are presented in Formula (I): wherein R1 represents a carbamoyl group; R2 represents a lower alkyl group; both of X1 and X2 represent CH, or any one of X1 and X2 represents a nitrogen atom and the other represents CH; a group of represents a group selected from the group consisting of a pyridinyl, a pyrazinyl, a pyrazolyl, a thiadiazolyl, a triazolyl, an isoxazolyl and a thiazolyl group; and k is zero or 1, or relates to pharmaceutically acceptable salts thereof.
US08609696B2 Serotonin 5-HT2B receptor inhibitors
Disclosed are Serotonin 5-HT2B receptor inhibitors of the formula I. Also disclosed are methods of making and methods of using these compounds.
US08609685B2 SMAC mimetic compounds as apoptosis inducers
The present invention relates to compounds conformationally constrained mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
US08609683B2 Pharmaceutical formulation containing gelling agent
Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together with one or more pharmaceutically acceptable excipients; the dosage form further including a gelling agent in an effective amount to impart a viscosity unsuitable for administration selected from the group consisting of parenteral and nasal administration to a solubilized mixture formed when the dosage form is crushed and mixed with from about 0.5 to about 10 ml of an aqueous liquid; the dosage form providing a therapeutic effect for at least about 12 hours when orally administered to a human patient.
US08609680B2 2,3-dihydro-1H-inden-1-yl-2,7-diazaspiro[3.5] nonane derivatives
The present invention provides a compound of Formula (I) or a pharmaceutically salt thereof wherein R1, R2, Ra, L, Z, Z1 and Z2 are as defined herein, that act as Ghrelin antagonists or inverse agonists; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by the antagonism of the Ghrelin receptor.
US08609676B2 4, 5, 6-trisubstituted pyrimidine derivatives as factor IXa inhibitors
The present invention relates to novel heterocyclic compounds of Formulae (I): (Chemical formula should be inserted here as it appears on abstract in paper form) Formula (I) as disclosed herein, or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are pharmaceutical compositions comprising said compounds, and methods for using said compounds for treating or preventing a thromboembolic disorder.
US08609674B2 Potassium channel modulators
Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein G1, R2, R1a, R1b, X, X1, X2, X3, Rx, J, k, n, q, and t are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.
US08609672B2 Piperazinylpyrimidine analogues as protein kinase inhibitors
The invention provides novel compounds based on piperazinylpyrimidine derivatives to be used as protein kinase inhibitors. The compounds may be useful in treating or preventing different cellular proliferation disorders, such as cancer. The present invention also provides methods of preparing these compounds, and methods of using the same.
US08609671B2 Method of inhibiting hepatic fibrosis as a result of liver replacement or repair using A2B adenosine receptor antagonists
The invention is related to methods of inhibiting hepatic fibrosis using A2B adenosine receptor antagonists and utility in the treatment and prevention of liver damage caused by alcohol abuse, surgical intervention, viral hepatitis, the ingestion of hepatotoxic drugs, or other hepatic diseases. The invention also relates to pharmaceutical compositions for use in the method.
US08609669B2 Potassium channel modulators
Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein R1, R2, R3, R4, and R5 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.
US08609667B2 E-type phenyl acrylic ester compounds containing substituted anilino pyrimidine group and uses thereof
Disclosed is a kind of E-type phenyl acrylic ester compound containing substituted anilino pyrimidine group, which is shown by general structure formula I, wherein each substituent is defined as that in the description. The compounds of general formula I show high insecticidal and acaricidal activities to adults and nymphs of harmful insects and mites in agricultural, civil and zoic technical fields, especially to Tetranychus cinnabarinus, Tetranychidae, and the like. The said compounds show more excellent performance on inhibiting the incubation of eggs of harmful mites. The uses of the said compounds as insecticides and/or acaricides in agricultural and other fields also are disclosed.
US08609660B2 4,7-dihydro-pyrazolo[1,5-a]pyrazin-6-ylamine derivatives useful as inhibitors of beta-secretase (BACE)
The present invention relates to novel 4,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl-amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid.
US08609657B2 Compounds
The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
US08609656B2 Heteroarylphenylurea derivative
The present invention provides a compound represented by the formula (1): wherein R1, R2 and R5 are each independently selected from a hydrogen atom, a halogen atom, a C1-C6 alkyl is substituted with a halogen atom and the like; R3 and R4 are each independently selected from a hydrogen atom, a halogen atom, a substituted C1-C6 alkyl group and the like; R6 and R7 are each independently selected from a hydrogen atom and a halogen atom; Z1 and Z2 are each independently selected from a hydrogen atom, a hydroxyl group and —O(CHR11)OC(═O)R12; Q is a group of the formula: (wherein G1 is C—Y2 or N; a ring A is a benzene ring or a 5- to 6-membered unsaturated heterocycle) a pharmaceutically acceptable salt thereof or a prodrug thereof.
US08609650B2 Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as Axl inhibitors
Bridged bicyclic aryl or heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
US08609648B2 Hepatitis C virus inhibitors
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
US08609647B2 Nitrogen-containing spirocyclic compounds and pharmaceutical uses thereof
A compound of the following general formula [I]: wherein each symbol has the same meaning as defined herein, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a pharmaceutical use of the same in treating organ transplant rejection, graft versus host reaction after transplantation, autoimmune disease, allergic disease and chronic myeloproliferative disease.
US08609644B2 Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders
Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. Said compounds are used for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
US08609643B2 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs
This invention discloses 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25R)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
US08609642B2 Skin treatment compositions
The present invention relates to compositions, kits and methods for treating skin at sites of concerns such as infectious lesions and/or points of insertion of an insertable medical device to prevent contamination such as infections or protein absorption that may interfere with the function of the device. The composition can be a topical skin treatment composition that includes polyethylene glycol (PEG), triclosan, one or more of a salicylate, bronopol, and an acrylic emulsion, and, optionally, a solvent.
US08609641B2 (S)-2-N-propylamino-5-hydroxytetralin as a D3-agonist
The invention relates to a medicament containing (S)-2-N-propylamino-5-hydroxytetralin, the salts or prodrugs thereof. As a D3 agonist, (S)-2-N-propylamino-5-hydroxytetralin is suitable particularly for the treatment of dopa-sensitive movement disorders.
US08609640B2 Multikinase inhibitors for use in the treatment of cancer
The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.
US08609632B2 Low molecular weight heparin composition and uses thereof
Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
US08609631B2 Compositions and methods for treating cancer
Provided herein are compounds used to inhibit the deamination enzyme responsible for the inactivation of therapeutic compounds, and methods of using them.
US08609629B2 Kits and methods for nutrition supplementation
The present invention relates to methods of co-administration of various vitamin and mineral compositions, and in a specific embodiment, said methods comprise co-administering one composition comprising vitamin A, beta carotene, B-complex vitamins, vitamin C, vitamin D3, vitamin E, iron, magnesium and zinc, and a second composition comprising omega-3 fatty acids such as DHA, to supplement the nutritional needs of individuals within physiologically stressful states; and kits provided for co-administration of various vitamin and mineral compositions, and in a specific embodiment, said kits comprise one composition comprising vitamin A, beta carotene, B-complex vitamins, vitamin C, vitamin D3, vitamin E, iron, magnesium and zinc, and a second composition comprising omega-3 fatty acids such as DHA, to supplement the nutritional needs of individuals within physiologically stressful states.
US08609628B2 Fused pentacyclic polyethers
Disclosed are polycyclic polyether compounds of formula I and pharmaceutical compositions comprising such compounds. wherein R, OR1, and R2 are as defined herein. Also disclosed are methods of regulating mucus clearance in a cell, and methods of treating decreased mucus clearance or mucociliary dysfunction.
US08609625B2 Method for enhancing immune response in the treatment of infectious and malignant diseases
The present invention pertains to a new approach for the treatment of infectious and malignant diseases. The present invention provides new DNA and protein vaccines for the treatment of infectious and malignant diseases through enhancing immune response.
US08609621B2 Acid-cleavable linkers exhibiting altered rates of acid hydrolysis
An acid-cleavable peptide linker comprising aspartic acid and proline residues is disclosed. The acid-cleavable peptide linker provides an altered sensitivity to acid-hydrolytic release of peptides of interest from fusion peptides of the formula PEP1-L-PEP2. The inventive linker, L, is described in various embodiments, each of which provides substantially more rapid acid-release of peptides of interest than does a single aspartic acid-proline pair. In an additional aspect, a method of increasing the stability of an acid cleavable linkage to acid hydrolysis is also provided.
US08609620B2 Neuregulin peptides and their use
Neuregulin peptides useful, for example, in methods and compositions for preventing, treating or delaying various diseases or disorders are described.
US08609613B2 Methods of inhibiting type 2 vascular endothelial growth factor receptors using polypeptides
The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
US08609609B2 Peptides and methods of use as therapeutics and screening agents
Host RNA/viral protein interaction as a target of intervention in the replication of viruses, e.g., the human immunodeficiency virus (HIV) are described. The target being upstream of the final replication product, and being crucial to the viral replication, is less likely to be genetically altered to drug resistance. Peptides that intervene in this RNA/viral protein interaction are also described, as well as compositions containing the same and methods of use thereof.
US08609601B2 Personal cleansing composition
This invention relates to a liquid or soft-solid personal cleansing composition that utilises the detergency properties of new materials which are more efficient, more inexpensive and are an environmentally friendly alternative to conventional soaps or synthetic surfactants. It more particularly relates to a cleansing composition in liquid, gel or cream formats. The present invention provides for a personal cleansing composition comprising (i) 1 to 50% of treated clay particles; and (ii) a cosmetically acceptable base; wherein said treated clay particles are asymmetric 1:1 or 2:1:1 clay particles having alternating tetrahedral and octahedral sheets terminating with a tetrahedral sheet at one external surface plane and an octahedral sheet at another external surface plane, with a fatty acid of carbon chain length 10 to 22 attached to coordinating cation on one of said exterior surface planes.
US08609600B2 Encapsulation of bulky fragrance molecules
A fragrance composition to be incorporated into the core of a core shell capsule, including: I) 60-100% by weight of at least 5 different fragrance compounds, each of the at least 5 different fragrance compounds possessing any of the structural features a) to g) defined in the specification, and II) 0-40% by weight of other benefit agents which possess any of the structural features a) to g), pro-fragrances, and solvents.
US08609598B2 Grease composition having a base oil, a thickener and an additive including a metal salt of dibasic acid
The present invention relates to a nitrite free grease composition having an oil base, a thickener, and several additives, including a metal salt of dibasic acid. The metal salt having sub-groups that can either be aliphatic or aromatic hydrocarbons. Additionally, the present invention relates to a grease-sealed bearing with a longer lifetime and excellent rust preventative properties.
US08609596B2 Gear oil composition
To provide a gear oil composition containing a base oil, and compounded therein, (A) an ashless dithiocarbamate compound and (B) an ester of pentaerythritol and a C12 to C20 branched fatty acid, the ester having a hydroxyl value of 20 to 100 mg KOH/g. The gear oil composition has a high transmission efficiency and shows both of resistance to sludge formation and extreme pressure property.
US08609595B2 Methods for determining reactive index for cement kiln dust, associated compositions, and methods of use
A variety of methods and compositions are disclosed, including, in one embodiment, a method of treating a well comprising: providing a treatment fluid comprising a base fluid and a blended cementitious component, wherein the blended cementitious component comprises kiln dust from two or more different sources; and introducing the treatment fluid into a well bore.
US08609590B2 Synergistic combination of flumetsulam with thiabendazole
A synergistic antimicrobial composition containing flumetsulam and thiabendazole.
US08609588B2 Synergistic herbicidal composition containing penoxsulam and glyphosate
A synergistic mixture of penoxsulam and glyphosate controls weeds in crops, especially vines, range and pasture, industrial vegetation management, rights of way and in any glyphosate tolerant crop.
US08609584B2 Thermal transfer sheet
There is provided a thermal transfer sheet including a thermal transfer dye layer formed on one surface of a base sheet and containing a dye and a heat resistant smooth layer formed on the other surface of the base sheet and containing a binder, a lubricant, and a filler. The binder contained in the heat resistant smooth layer is obtainable by mixing a polyvinyl acetoacetal resin with an acryl silicone resin which has a mass average molecular weight of 100,000 or more and is in the form of a powdery solid at an ordinary temperature at a ratio of 10 parts by mass or less of the acryl silicone resin relative to 100 parts by mass of the polyvinyl acetoacetal resin, and the heat resistant smooth layer further contains 10 parts by mass or more and 30 parts by mass or less of isocyanate relative to 100 parts by mass of the polyvinyl acetoacetal resin and phosphoric acid ester having a melting point of 50° C. or more as the lubricant.
US08609581B2 Honeycomb structure and honeycomb catalytic body
A honeycomb structure includes: porous partition walls having a large number of pores and disposed to form a plurality of cells communicating between two end faces, and plugged portions disposed to plug each of the cells on one of the end faces. A percentage of the number of carbon particulates contained in combustion exhaust gas satisfying the following condition (1) and passing through a honeycomb structure is 80% or more at a space velocity of 25000/h. The condition (1) is that the carbon particulates has a mean diameter of 0.07 to 0.2 μm, a ratio of the carbon particulates having a diameter of 1 μm or more is 0.1% or less in number and that a concentration of the carbon particulates is 10 mg/m3. The honeycomb structure is excellent in purification efficiency, has low pressure loss, and is mountable even in a limited space.
US08609577B2 Catalyst for steam reforming of methanol
A catalyst for steam reforming of methanol, which includes a carrier material comprising a metal oxide and deposited thereon a) indium oxide (In2O3) and at least one further metal from the group of palladium (Pd), platinum (Pt), rhodium (Rh) and iridium (Ir) and/or b) an alloy comprising indium and at least one further metal from the group of palladium (Pd), platinum (Pt), rhodium (Rh) and iridium (Ir), as catalytically active substances.
US08609575B2 Sulfur resistant emissions catalyst
A catalyst of one or more complex oxides having a nominal composition as set out in formula (1): AxB1-y-zMyPzOn (1) wherein A is selected from one or more group III elements including the lanthanide elements or one or more divalent or monovalent cations; B is selected from one or more elements with atomic number 22 to 24, 40 to 42 and 72 to 75; M is selected from one or more elements with atomic number 25 to 30; P is selected from one or more elements with atomic number 44 to 50 and 76 to 83; x is defined as a number where 0
US08609565B1 Low-temperature protonic conduction for hydrogen-related energy applications employing nanostructured functional oxides
The present invention provides a proton conducting thin film having a dense nanometric ceramic material with a relative density of at least about 90% and a grain size of less than about 30 nm, wherein the proton conducting thin film is capable of operating at temperatures of less than about 100° C. in the presence of water vapor. The present invention also provides an electrochemical device using the proton conducting thin film, and a method of making the proton conducting thin film.
US08609559B2 Glass compositions, dielectric compositions and multilayer ceramic capacitor having high capacitance using the same
Disclosed are a glass composition and a dielectric composition enabling low temperature sintering, and a high capacitance multilayer ceramic capacitor using the same. In the glass composition used for sintering, the glass composition may be formed of a formula, aR2O-bCaO-cZnO-dBaO-eB2O3-fAl2O3-gSiO2, and the formula may satisfy a+b+c+d+e+f+g=100, 0≦a≦7, 1≦b≦3, 1≦c≦15, 10≦d≦20, 3≦e≦10, 0≦f≦3, and 55≦g≦72. Through this, when manufacturing the high capacity multilayer ceramic capacitor, the dielectric substance may enable the lower temperature sintering, thereby enhancing a capacitance and a reliability of the high capacitance multilayer ceramic capacitor.
US08609557B2 Textile semifinished product with at least one surface provided with an adhesive
A textile semifinished product with at least one surface provided with an adhesive, wherein the adhesive is immobilized on the surface of the semifinished product in order to maintain the tack in a lasting manner. To this end, at least one constituent of the adhesive is partly crosslinked and the partly crosslinked constituent is the product of partial crosslinking of at least one monomer containing double bonds, the monomer containing double bonds being a partial ester prepared by the reaction of an epoxy resin with an unsaturated carboxylic acid.
US08609554B2 Semiconductor structure and method for manufacturing the same
A semiconductor structure and a method for manufacturing the same are provided. The method comprises following steps. A first silicon-containing conductive material is formed on a substrate. A second silicon-containing conductive material is formed on the first silicon-containing conductive material. The first silicon-containing conductive material and the second silicon-containing conductive material have different dopant conditions. The first silicon-containing conductive material and the second silicon-containing conductive material are thermally oxidized for turning the first silicon-containing conductive material wholly into an insulating oxide structure, and the second silicon-containing conductive material into a silicon-containing conductive structure and an insulating oxide layer.
US08609553B2 Methods of forming rutile titanium dioxide and associated methods of forming semiconductor structures
Methods of forming rutile titanium dioxide. The method comprises exposing a transition metal (such as V, Cr, W, Mn, Ru, Os, Rh, Ir, Pt, Ge, Sn, or Pb) to oxygen gas (O2) to oxidize the transition metal. Rutile titanium dioxide is formed over the oxidized transition metal. The rutile titanium dioxide is formed by atomic layer deposition by introducing a gaseous titanium halide precursor and water to the oxidized transition metal. Methods of forming semiconductor structures having rutile titanium dioxide are also disclosed.
US08609552B2 Method for controlling dangling bonds in fluorocarbon films
Embodiments of the invention describe methods for forming fluorocarbon (CF) films for semiconductor devices. According to one embodiment, the method includes providing a substrate, depositing a CF film on the substrate, generating, in the absence of a plasma, a treatment gas containing a gaseous specie having a molecular dipole, and treating the CF film with the treatment gas containing the gaseous specie having the molecular dipole to reduce the number of dangling bonds in the CF film. According to some embodiments, the method further includes depositing a second CF film on the treated CF film. According to some embodiments, the CF films may be deposited using a microwave plasma source containing a radial line slot antenna (RLSA).
US08609548B2 Method for providing high etch rate
A method for etching features into an etch layer in a plasma processing chamber, comprising a plurality of cycles is provided. Each cycle comprises a deposition phase and an etching phase. The deposition phase comprises providing a flow of deposition gas, forming a plasma from the deposition gas in the plasma processing chamber, providing a first bias during the deposition phase to provide an anisotropic deposition, and stopping the flow of the deposition gas into the plasma processing chamber. The etching phase, comprises providing a flow of an etch gas, forming a plasma from the etch gas in the plasma processing chamber, providing a second bias during the etch phase, wherein the first bias is greater than the second bias, and stopping the flow of the etch gas into the plasma processing chamber.
US08609544B2 Method for fabricating semiconductor device
A method for fabricating a semiconductor device, comprising forming a first photoresist pattern having a hole on a first layer, forming a surface curing layer in the hole and curing the first photoresist pattern on an inner sidewall of the hole to form a first curing pattern, removing the surface curing layer, forming a second photoresist pattern in the hole and curing the second photoresist pattern that contacts with the first curing pattern to form a second curing pattern, removing the first and second photoresist patterns, and etching the first layer using the first and second curing patterns as an etch barrier.
US08609543B2 Method for manufacturing semiconductor device having multi-layered hard mask layer
A method for fabricating a semiconductor device includes providing a substrate having a first and a second region, forming an etch target layer over the substrate, forming a hard mask layer over the etch target layer to have different thicknesses over the first and the second regions, forming a hard mask pattern by etching the hard mask layer, and etching the etch target layer using the hard mask pattern as an etch mask to form a target pattern having different densities over the first and the second regions.
US08609535B2 Semiconductor package having through electrodes that reduce leakage current and method for manufacturing the same
A stacked semiconductor package having through electrodes that exhibit a reduced leakage current and a method of making the same are presented. The stacked semiconductor package includes a semiconductor chip, through-holes, and a current leakage prevention layer. The semiconductor chip has opposing first and second surfaces. The through-holes pass entirely through the semiconductor chip and are exposed at the first and second surfaces. A polarized part is formed on at least one of the first and second surfaces of the semiconductor chip. The through-electrodes are disposed within the through-holes. The current leakage prevention layer covers the polarized part and exposes ends of the through-electrodes.
US08609533B2 Methods for fabricating integrated circuits having substrate contacts and integrated circuits having substrate contacts
Methods for fabricating integrated circuits having substrate contacts and integrated circuits having substrate contacts are provided. One method includes forming a first trench in a SOI substrate extending through a buried insulating layer to a silicon substrate. A metal silicide region is formed in the silicon substrate exposed by the first trench. A first stress-inducing layer is formed overlying the metal silicide region. A second stress-inducing layer is formed overlying the first stress-inducing layer. An ILD layer of dielectric material is formed overlying the second stress-inducing layer. A second trench is formed extending through the ILD layer and the first and second stress-inducing layers to the metal silicide region. The second trench is filled with a conductive material.
US08609529B2 Fabrication method and structure of through silicon via
A method of fabricating a through silicon via (TSV) structure, in which, a patterned mask is formed on a substrate, the patterned mask has an opening, a spacer-shaped structure is formed on a sidewall of the opening, and a via hole having a relatively enlarged opening is formed by etching the spacer-shaped structure and the substrate through the opening after the spacer-shaped structure is formed. A TSV structure, in which, a via hole has an opening portion and a body portion, the opening portion is a relatively enlarged opening and has a tapered shape having an opening size of an upper portion greater than an opening size of a lower portion.
US08609525B2 Integrated circuit packaging system with interconnects and method of manufacture thereof
A method of manufacture of an integrated circuit packaging system includes: providing a package carrier having a carrier top side; mounting an integrated circuit over the carrier top side; attaching a bottom attachment directly on the integrated circuit; dragging a sandwich connector from the bottom attachment, the sandwich connector having a connector diameter; and attaching a top attachment directly on the sandwich connector, the top attachment wider than the bottom attachment.
US08609519B2 Combinatorial approach for screening of ALD film stacks
In some embodiments of the present invention, methods of using one or more small spot showerhead apparatus to deposit materials using CVD, PECVD, ALD, or PEALD on small spots in a site isolated, combinatorial manner are described. The small spot showerheads may be configured within a larger combinatorial showerhead to allow multi-layer film stacks to be deposited in a combinatorial manner.
US08609514B2 Process for the transfer of a thin film comprising an inclusion creation step
A process for transferring a thin film includes forming a layer of inclusions to create traps for gaseous compounds. The inclusions can be in the form of one or more implanted regions that function as confinement layers configured to trap implanted species. Further, the inclusions can be in the form of one or more layers deposited by a chemical vapor deposition, epitaxial growth, ion sputtering, or a stressed region or layer formed by any of the aforementioned processes. The inclusions can also be a region formed by heat treatment of an initial support or by heat treatment of a layer formed by any of the aforementioned processes, or by etching cavities in a layer. In a subsequent step, gaseous compounds are introduced into the layer of inclusions to form micro-cavities that form a fracture plane along which the thin film can be separated from a remainder of the substrate.
US08609513B2 Method for manufacturing semiconductor device
A method for manufacturing a semiconductor device includes the steps of: preparing a combined wafer; obtaining a first intermediate wafer by forming an active layer; obtaining a second intermediate wafer by forming a front-side electrode on the first intermediate wafer; supporting the second intermediate wafer by adhering an adhesive tape at the front-side electrode side; removing the supporting layer while supporting the second intermediate wafer using the adhesive tape; forming a backside electrode on the main surfaces of SiC substrates exposed by the removal of the supporting layer; adhering an adhesive tape at the backside electrode side and removing the adhesive tape at the front-side electrode side so as to support the plurality of SiC substrates using the adhesive tape; and obtaining a plurality of semiconductor devices by cutting the SiC substrates with the SiC substrates being supported by the adhesive tape provided at the backside electrode side.
US08609501B2 Fluorine implant under isolation dielectric structures to improve bipolar transistor performance and matching
A method of fabricating an integrated circuit including bipolar transistors that reduces the effects of transistor performance degradation and transistor mismatch caused by charging during plasma etch, and the integrated circuit so formed. A fluorine implant is performed at those locations at which isolation dielectric structures between base and emitter are to be formed, prior to formation of the isolation dielectric. The isolation dielectric structures may be formed by either shallow trench isolation, in which the fluorine implant is performed after trench etch, or LOCOS oxidation, in which the fluorine implant is performed prior to thermal oxidation. The fluorine implant may be normal to the device surface or at an angle from the normal. Completion of the integrated circuit is then carried out, including the use of relatively thick copper metallization requiring plasma etch.
US08609500B2 Semiconductor device production method
A semiconductor device production method includes: forming in a silicon substrate first and second region of first and second conductivity type in contact with each other; forming a gate electrode above the first and the second region; forming an insulation film covering part of the gate electrode and part of the second region; forming a source region and a drain region of the second conductivity type; forming interlayer insulation film covering the gate electrode and the insulation film; and forming in the interlayer insulation film first, second and third contact hole reaching the source region, the drain region, and the gate electrode, respectively, and at least one additional hole reaching the insulation film, and forming a conductive film in the first, the second, and the third contact hole and the additional hole to form first, second and third electrically conductive via and electrically conductive member.
US08609499B2 FinFETs and the methods for forming the same
A method includes forming a gate stack including a gate electrode on a first semiconductor fin. The gate electrode includes a portion over and aligned to a middle portion of the first semiconductor fin. A second semiconductor fin is on a side of the gate electrode, and does not extend to under the gate electrode. The first and the second semiconductor fins are spaced apart from, and parallel to, each other. An end portion of the first semiconductor fin and the second semiconductor fin are etched. An epitaxy is performed to form an epitaxy region, which includes a first portion extending into a first space left by the etched first end portion of the first semiconductor fin, and a second portion extending into a second space left by the etched second semiconductor fin. A first source/drain region is formed in the epitaxy region.
US08609492B2 Vertical memory cell
Methods of forming, devices, and apparatus associated with a vertical memory cell are provided. One example method of forming a vertical memory cell can include forming a semiconductor structure over a conductor line. The semiconductor structure can have a first region that includes a first junction between first and second doped materials. An etch-protective material is formed on a first pair of sidewalls of the semiconductor structure above the first region. A volume of the first region is reduced relative to a body region of the semiconductor structure in a first dimension.
US08609489B2 Methods of forming memory; and methods of forming vertical structures
Some embodiments include methods of forming memory. A series of photoresist features may be formed over a gate stack, and a placeholder may be formed at an end of said series. The placeholder may be spaced from the end of said series by a gap. A layer may be formed over and between the photoresist features, over the placeholder, and within said gap. The layer may be anisotropically etched into a plurality of first vertical structures along edges of the photoresist features, and into a second vertical structure along an edge of the placeholder. A mask may be formed over the second vertical structure. Subsequently, the first vertical structures may be used to pattern string gates while the mask is used to pattern a select gate. Some embodiments include methods of forming conductive runners, and some embodiments may include semiconductor constructions.
US08609487B2 Method of manufacturing semiconductor device
A method of manufacturing a semiconductor device comprising a first insulating film formed on a semiconductor substrate, a charge storage layer formed on the first insulating film, a second insulating film formed on the charge storage layer, and a control electrode formed on the second insulating film, wherein forming the second insulating film comprises forming an insulating film containing silicon using source gas not containing chlorine, and forming an insulating film containing oxygen and a metal element on the insulating film containing silicon.
US08609485B2 Methods of forming efuse devices
A semiconductor-based electronic fuse may be provided in a sophisticated semiconductor device having a bulk configuration by appropriately embedding the electronic fuse into a semiconductor material of reduced heat conductivity. For example, a silicon/germanium fuse region may be provided in the silicon base material. Consequently, sophisticated gate electrode structures may be formed on the basis of replacement gate approaches on bulk devices substantially without affecting the electronic characteristics of the electronic fuses.
US08609480B2 Methods of forming isolation structures on FinFET semiconductor devices
One illustrative method disclosed herein includes performing at least one etching process on a semiconducting substrate to form a plurality of trenches and a plurality of fins for the FinFET device in the substrate, forming a first layer of insulating material in the trenches, wherein an upper surface of the first layer of insulating material is below an upper surface of the substrate, forming an isolation layer within the trenches above the first layer of insulating material, wherein the isolation layer has an upper surface that is below the upper surface of the substrate, forming a second layer of insulating material above the isolation layer, wherein the second layer of insulating material has an upper surface that is below the upper surface of the substrate, and forming a gate electrode structure above the second layer of insulating material.
US08609475B2 Methods for forming nickel oxide films for use with resistive switching memory devices/US
Methods for forming a NiO film on a substrate for use with a resistive switching memory device are presenting including: preparing a nickel ion solution; receiving the substrate, where the substrate includes a bottom electrode, the bottom electrode utilized as a cathode; forming a Ni(OH)2 film on the substrate, where the forming the Ni(OH)2 occurs at the cathode; and annealing the Ni(OH)2 film to form the NiO film, where the NiO film forms a portion of a resistive switching memory element. In some embodiments, methods further include forming a top electrode on the NiO film and before the forming the Ni(OH)2 film, pre-treating the substrate. In some embodiments, methods are presented where the bottom electrode and the top electrode are a conductive material.
US08609473B2 Method for fabricating a neo-layer using stud bumped bare die
A method for fabricating a stackable integrated circuit layer and a device made from the method are disclosed. A stud bump is defined on the contact pad of an integrated circuit die and the stud-bumped die encapsulated in a potting material to define a potted assembly. A predetermined portion of the potting material is removed whereby a portion of the stud bump is exposed. One or more electrically conductive traces are defined on the layer surface and in electrical connection with the stud bump to reroute the integrated circuit contacts to predetermined locations on the layer to provide a stackable neolayer.
US08609472B2 Process for fabricating electronic components using liquid injection molding
A process for fabricating an electronic component includes a liquid injection molding method for overmolding a semiconductor device. The liquid injection molding method includes: i) placing the semiconductor device in an open mold, ii) closing the mold to form a mold cavity, iii) heating the mold cavity, iv) injection molding a curable liquid into the mold cavity to overmold the semiconductor device, v) opening the mold and removing the product of step iv), and optionally vi) post-curing the product of step v). The semiconductor device may have an integrated circuit attached to a substrate through a die attach adhesive.
US08609470B2 Semiconducting sheet
A substrate-free semiconducting sheet has an array of semiconducting elements dispersed in a matrix material. The matrix material is bonded to the edge surfaces of the semiconducting elements and the substrate-free semiconducting sheet is substantially the same thickness as the semiconducting elements.
US08609468B2 Semiconductor device and method of manufacturing the same
To provide a semiconductor device having suspension leads with less distortion. In QFN having a plurality of external terminal portions at the periphery of the bottom surface of a sealing body, a plurality of leads is linked to a plurality of long suspension leads of the QFN at an intermediate portion thereof or at between the intermediate portion and a position near the die pad. These long suspension leads are each supported by these leads, making it possible to suppress distortion of each of the suspension leads in a wire bonding step or molding step in the fabrication of the QFN.
US08609466B2 Cap and substrate electrical connection at wafer level
A cap and substrate having an electrical connection at a wafer level includes providing a substrate and forming an electrically conductive ground structure in the substrate and electrically coupled to the substrate. An electrically conductive path to the ground structure is formed in the substrate. A top cap is then provided, wherein the top cap includes an electrically conductive surface. The top cap is bonded to the substrate so that the electrically conductive surface of the top cap is electrically coupled to the path to the ground structure.
US08609465B2 Semiconductor device manufacturing method
A method for manufacturing a semiconductor device includes: a step of producing a semiconductor package intermediate by injecting a resin into a forming die in which electrodes, a heat dissipating pad, and a semiconductor element are disposed, providing a peel-off film on one side of the resin in the form of a still-uncured resin body opposite from the other side facing the heat dissipating pad and a rigid material on one side of the peel-off film, and curing the uncured resin body to form a sealant resin body; a step of forming a solder layer by reflow soldering between a substrate and the intermediate; and a step of removing the rigid material from the peel-off film, wherein the rigid material is integrated into the intermediate so as to make the thermal expansion coefficient and rigidity of the intermediate approximately equal to those of the substrate.
US08609463B2 Integrated circuit package system employing multi-package module techniques
An integrated circuit package system that includes: providing a first package including a first package first device and a first package second device both adjacent a first package substrate; and mounting and electrically interconnecting a second package over an electrical interconnect array formed on a substrate of the first package second device.
US08609462B2 Methods for forming 3DIC package
A method includes dispensing an underfill between a first package component and a second package component, wherein the first package component is placed on a lower jig, and the second package component is over and bonded to the first package component. A through-opening is in the lower jig and under the first package component. The underfill is cured, wherein during the step of curing the underfill, a force is applied to flatten the first package component. The force is applied by performing an action selected from the group consisting of vacuuming and air blowing through the through-opening.
US08609457B2 Semiconductor device with DRAM bit lines made from same material as gate electrodes in non-memory regions of the device, and methods of making same
Generally, the present disclosure is directed to a semiconductor device with DRAM bit lines made from the same material as the gate electrodes in non-memory regions of the device, and methods of making the same. One illustrative method disclosed herein comprises forming a semiconductor device including a memory array and a logic region. The method further comprises forming a buried word line in the memory array and, after forming the buried word line, performing a first common process operation to form at least a portion of a conductive gate electrode in the logic region and to form at least a portion of a conductive bit line in the memory array.
US08609453B2 Low cost solar cell manufacture method employing a reusable substrate
A reusable substrate and method for forming single crystal silicon solar cells are described. A method of forming a photovoltaic cell includes forming an intermediate layer on a monocrystalline silicon substrate, forming a monocrystalline silicon layer on the intermediate layer, and forming electrical features in the monocrystalline silicon layer. The method further includes forming openings in the monocrystalline silicon layer, and detaching the monocrystalline silicon layer from the substrate by selectively etching the intermediate layer through the openings.
US08609450B2 MEMS switches and fabrication methods
MEMS switches and methods of fabricating MEMS switches. The switch has a vertically oriented deflection electrode having a conductive layer supported by a supporting layer, at least one drive electrode, and a stationary electrode. An actuation voltage applied to the drive electrode causes the deflection electrode to be deflect laterally and contact the stationary electrode, which closes the switch. The deflection electrode is restored to a vertical position when the actuation voltage is removed, thereby opening the switch. The method of fabricating the MEMS switch includes depositing a conductive layer on mandrels to define vertical electrodes and then releasing the deflection electrode by removing the mandrel and layer end sections.
US08609445B2 Optical transmission module and manufacturing method of the same
[Problems] To accommodate a plurality of optical semiconductor elements in one package with their optical axes aligned highly precisely. [Means for Solving the Problems]An optical transmission module includes an optical transmission unit, a carrier to become a base, a semiconductor optical amplification element mounted on the carrier through a first sub-carrier, first and second lenses fixed on the carrier through first and second lens holders, an element supporting member and an optical isolator fixed on the carrier, a third lens holder supported by the element supporting member, a third lens and a small carrier individually fixed in the third lens holder, and a semiconductor laser element mounted on the small carrier through a second sub-carrier.
US08609433B2 Multiplanar lateral flow assay with sample compressor
A sample compressor applies pressure to a sample collector and a sample application zone of a test strip to transfer a sample from the sample collector and a binding partner of an analyte to the sample application zone in a lateral flow device. At least one of the binding partners of the analyte is not located on the test strip prior to use of the lateral flow device. The test strip may be a universal test strip with no molecule that specifically binds the analyte is located on the test strip. The sample compressor may be a universal sample compressor also with no molecule that specifically binds the analyte on the sample compressor. The lateral flow device may also include one or more enhancement elements, where the enhancement elements bind to the analyte sandwich to increase a detection signal in the test zone.
US08609430B2 Sample processing units, systems, and related methods
Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.
US08609427B2 SO2 detection using differential nano-resonators and methods related thereto
A sulfur dioxide sensor comprising a first beam having a functionalized sensing surface capable of sensing sulfur dioxide, the first beam capable of producing a first resonant frequency; and a second beam having a functionalized reference surface not capable of sensing sulfur dioxide, the second beam capable of producing a second resonant frequency, wherein differential sensing of sulfur dioxide may be performed, further wherein the first beam is functionalized with a liquid phase of a first polymeric compound and the second beam is functionalized with a liquid phase of a second polymeric compound is provided. In one embodiment, the sensor is a nano-sensor capable of low drift accurately detecting sulfur dioxide levels at the zeptograms level. Methods of making and using a sulfur dioxide sensor are also provided.
US08609426B2 Sensors for detecting substances indicative of stroke, ischemia, infection or inflammation
A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed.
US08609425B2 Determination of nitrate/nitrite concentration in water by quantitative photochemical reduction using NH4CL and EDTA
Methods for determining the concentration of nitrates in several types of water samples by photochemical reduction without the use of toxic materials such as cadmium or hydrazine, and having an approximately 100% reduction efficiency are described. A water sample mixed with a buffered aqueous solution including ammonium salts and EDTA is irradiated using ultraviolet light having wavelengths effective for photochemical conversion of nitrate and nitrite ions (NOx) to detectable species. The resulting species may be quantitatively determined by diazotization using sulfanilamide followed by coupling with N-(1-napthyl)ethylenediamine dihydrochloride which produces a water-soluble azo dye having a magenta color which may be colorimetrically measured at 540 nm from which the nitrate and nitrite concentration in the sample is determined. Nitrite present in the original sample may be colorimetrically analyzed using an unphotolyzed sample and the reaction with sulfanilamide followed by coupling with N-(1-napthyl)ethylenediamine dihydrochloride. When the nitrite concentration is subtracted from the total of the nitrate and nitrite concentration, the sample nitrate may be determined.
US08609424B2 Antibody directed against pro-gastrin releasing peptide, and use thereof
Disclosed is a novel high-sensitive ProGRP measurement method, which is free from problems such as the fluctuations in measurement values and the operational constraints (e.g., the constraints on the handling of a sample). Specifically disclosed is a method for the measurement of a gastrin-releasing peptide precursor and/or a digested product thereof using at least two different antibodies each of which can recognize an epitope represented by the amino acid sequence consisting of amino acid 47 to amino acid 68 of the amino acid sequence set forth in SEQ ID NO:1. The method can detect a ProGRP or a digested product thereof in a refrigerated sample within a shorter period, by using the sample in a smaller amount, and with a higher degree of detective sensitivity, compared with the conventional methods.
US08609423B2 Rapid protein labeling and analysis
The present invention provides methods and compositions for labeling, separating and analyzing proteins, particularly a specific protein of interest within a cell lysate or in a mixture of proteins. The proteins are labeled with an amine reactive or thiol reactive fluorescent dye, or an amine reactive fluorogenic reagent that becomes fluorescent upon reacting to amine groups located on the protein. Following the labeling step, the proteins within the mixture can be separated and analyzed. In a further embodiment, a tag binding fluorogenic reagent that can bind to a tag on a tagged protein is added to specifically label the protein of interest.
US08609420B2 Quantum dot carrier peptide conjugates suitable for imaging and delivery applications in plants
Provided are methods for introducing a molecule of interest into a plant cell having a cell wall by using a QD-peptide conjugate having a quantum dot (QD) with one or more cell penetrating peptides (CPPs). Methods are provided for genetically or otherwise modifying plants and for treating or preventing disease in plant cells comprising a cell wall.
US08609415B2 Method for manufacturing a tissue-engineered construct
Method for manufacturing a tissue-engineered construct, such as a heart valve, comprising the steps of providing a-cell-seeded scaffold in a bioreactor chamber which bioreactor chamber is divided by the cell-seeded scaffold into a first compartment and a second compartment, subjecting the cell-seeded scaffold to a flow of nutrient medium within the bioreactor chamber for developing the cell-seeded scaffold to a tissue structure and next to the tissue construct, applying a dynamic pressure difference to the developing tissue structure by the flow of nutrient medium to induce dynamic strain on the tissue structure.
US08609414B2 Isolation and growth of stem cells from hemangiomas
The present invention describes stem cells and progenitor cells derived from hemangiomas, including testing of angiogenic inhibitors using these cells. The invention as described is useful in providing a process to culture and propagate hemangioma stem cells and generate xenograft models to develop treatments for infantile hemangiomas and other types of vascular lesions.
US08609407B2 Sp35 antibodies and uses thereof
Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.
US08609406B2 Non-static suspension culture of cell aggregates
The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, endodermal, and mesodermal embryonic germ layers, e.g., stem cells.
US08609405B2 GABA neuron progenitor cell marker 65B13
The present inventors identified a selective marker 65B13 for GABA neuron progenitor cells of the spinal dorsal horn and cerebellum, and successfully isolated GABA neuron progenitor cells using antibodies that bind to a protein encoded by the gene. 65B13 was demonstrated to be useful as a marker to isolate GABA-producing neuron progenitor cells in the spinal dorsal horn and cerebellum. GABA neuron progenitor cells can be efficiently identified or isolated by using the identified marker as an indicator.
US08609402B2 Multivalent vaccines comprising recombinant viral vectors
The invention relates to vaccines comprising recombinant vectors, such as recombinant adenoviruses. The vectors comprise heterologous nucleic acids encoding for at least two antigens from one or more tuberculosis-causing bacilli. Also described is the use of specific protease recognition sites linking antigens through which the encoded antigens are separated upon cleavage. After cleavage, the antigens contribute to the immune response in a separate manner. The recombinant vectors may comprise a nucleic acid encoding the protease cleaving the linkers and separating the antigens. Further described is the use of genetic adjuvants encoded by the recombinant vectors, wherein such genetic adjuvants may also be cleaved through the presence of the cleavable linkers and the specific protease.
US08609396B2 Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism
Disclosed herein are a microorganism strain capable of producing the L-methionine precursor O-acetyl homoserine in high yield and a method of producing O-acetyl homoserine using the same. The microorganism strain is a strain of Escherichia sp. in which an acetyl-CoA synthase gene (acs) and/or a pantothenate kinase gene (coaA) encoding a pantothenate kinase gene refractory to feedback inhibition by CoA is introduced and expressed.
US08609387B2 Fungal endoglucanases, their production and use
Novel fungal endoglucanases with substantial performance at low temperatures are disclosed. The endoglucanases are conveniently produced by recombinant technology, and means for their production are described. The endoglucanases are used for treating cellulosic material, especially in textile industry, e.g. in biofinishing or biostoning. They may also be used in detergents, in animal feed and/or in pulp and paper industry or bioethanol production.
US08609385B2 Methods for the direct conversion of carbon dioxide into a hydrocarbon using a metabolically engineered photosynthetic microorganism
The present invention relates to methods for the production of isoprene by the direct conversion of atmospheric carbon dioxide using metabolically engineered genetically engineered photosynthetic microorganisms. The present invention also relates to genetically engineered photosynthetic microorganisms, such as cyanobacteria, that are capable of producing isoprene from CO2.
US08609384B2 Processing biomass
Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce ethanol and/or butanol, e.g., by fermentation.
US08609371B2 Isoprenoid compounds
The present invention is directed to variant squalene synthase enzymes, including Saccharomyces cerevisiae squalene synthase enzymes, and to nucleic acid molecules encoding these variant enzymes. These variant enzymes produce squalene at a lower rate than the wild-type enzyme, allowing more farnesyl pyrophosphate to be utilized for production of isoprenoid compounds, while still producing sufficient squalene to allow the S. cerevisiae cells to grow without the requirement for supplementation by sterols such as ergosterol. These variant enzymes, therefore, are highly suitable for the efficient production of isoprenoids.
US08609367B2 Genes and proteins for the biosynthesis of the lantibiotic 107891
The invention relates to the field of lantibiotics, and more specifically to the isolation of nucleic acid molecules that code for the enzymes required for the biosynthetic pathway of the lantibiotic 107891 and the homologues thereof.
US08609363B2 Viability cell counting by differential light absorption
Cell counts that distinguish between live and dead cells while providing an accurate count of the total of live and dead cells are obtained by the use of a vital stain in conjunction with illumination of the cell population and the taking of light images at different wavelengths, one which is not absorbed by the stain and one that is absorbed by the stain. Masking and inaccuracies in the counting of dead cells is thereby avoided.
US08609359B2 Methods for determining the concentration of gamma-hydroxy butyric acid (GHB) in a sample
Methods to determine the concentration of gamma-hydroxy butyric acid (GHB) in a sample as well as compositions and a kit suitable for carrying out said methods. Also, the use of the methods for application on a microtiter plate or an auto-analyzer.
US08609358B2 Methods, peptides and biosensors useful for detecting a broad spectrum of bacteria
Described herein are methods of detecting a wound infection and for detecting the presence or absence of bacteria, for example, wound bacteria in a sample, by contacting a sample with a peptide substrate derived from the modification of the reactive site loop (RSL) domain of the α 1-proteinase inhibitor. In the current invention, we have demonstrated that these peptide substrates without the alpha 1 protein can be efficiently used as peptide substrates. The modification or the absence of modification of this peptide substrate by the enzyme produced and/or secreted by the bacteria, can serve as an indicator for the presence or absence of the bacteria in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.
US08609353B2 Diagnostics and methods for removal and detection of interferents
Described herein are substrates, methods, articles, and kits that are useful for removing interferents from samples for diagnostic purposes. The interferents are removed with phosphocellulose and cation exchange materials. These materials could also be used in vitro to improve the performance of a diagnostic assay or in vivo to remove the interferents.
US08609351B2 Detection of dysplastic or neoplastic cells using anti-MCM4 antibodies
Determination of cellular growth abnormality, particularly cancerous abnormality, by detection of target polypeptides or encoding mRNA, where the target polypeptides are members of the preinitiation complex of DNA replication in tissue, cells or fluid. Target polypeptides include CDC6, MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7. Test samples include tissue of the cervix (both biopsy and smear samples), breast, colon, lung, bladder, skin, larynx, oesophagus, bronchus, lymph nodes and urinary tract (both biopsy and cytology smear samples), in determination of cancerous and pre-cancerous cellular growth abnormality, and cells spun from urine, blood and serum, in determination of haematological malignancies and evidence of metastatic sarcoma and carcinoma.
US08609343B2 Detection of bladder cancer
Provided are methods for detecting bladder cancer in a subject. In some aspects, methylation of one or more of MYO3A, CA10, NKX6-2, SOX11, DBC1, NPTX2, and/or A2BP1 in DNA sediment from a urine sample may be evaluated to detect the presence or absence of a bladder cancer in a human patient.
US08609341B2 Uniform fragmentation of DNA using binding proteins
The invention provides a method for preparing and analysing a population of fragmented polynucleotide sequences having a substantially uniform size. The method can include steps of (a) binding at least one protection molecule to at least one polynucleotide sequence; (b) cleaving the at least one polynucleotide sequence to generate a plurality of polynucleotide fragment sequences of substantially uniform size; (c) amplifying the polynucleotide fragments; and (d) determining a sequence characteristic of a plurality of the polynucleotide fragments.
US08609339B2 System and method for emulsion breaking and recovery of biological elements
An embodiment of a method for extracting biological material from an emulsion is described that comprises the steps of a) breaking an emulsion comprising a plurality of aqueous droplets in a continuous phase of an oil using a solvent to produce a combined aqueous-oil mixture, where the solvent disrupts the aqueous droplets which release a plurality of biological elements each immobilized on a substrate into the combined aqueous-oil mixture; b) introducing an inorganic salt to the combined aqueous-oil mixture causing a phase separation of the mixture into a first phase comprising an aqueous solution and the biological elements and a second phase comprising the solvent and the oil; c) extracting the first phase from the second phase; and d) collecting the substrate immobilized biological elements from the first phase.
US08609335B2 Self-assembled single molecule arrays and uses thereof
The present invention provides methods of making and using self-assembled arrays of single polynucleotide molecules for carrying out a variety of large-scale genetic measurements, such as gene expression analysis, gene copy number assessment, and the like. Random arrays used in the invention are “self-assembled” in the sense that they are formed by deposition of polynucleotide molecules onto a surface where they become fixed at random locations. The polynucleotide molecules fixed on the surface are then identified by direct sequence determination of component nucleic acids, such as incorporated probe sequences, or by other decoding schemes. Such identification converts a random array of determinable polynucleotides, and their respective probes into an addressable array of probe sequences.
US08609332B2 Assay
RAN and RAN Binding Protein 1 have been determined to be markers of invasive and metastatic potential of a tumour cell. There is described methods and kits for the detection of the level of RAN and RAN Binding Protein 1 and the use thereof.
US08609330B2 Live Bioload detection using microparticles
The present invention provides methods to concentrate cells onto microparticles, to concentrate the microparticles, and to detect the cells. The present invention also includes unitary sample preparation and detection devices to be used in accordance with the methods.
US08609325B2 Method of lithography
A lithography method of manufacturing integrated circuits is disclosed. A photoalignment layer is formed on a substrate. A treatment is performed to reorganize and align the photoalignment molecules. A photoresist layer may be formed on the photoalignment layer in a bi-layer separate coating or with the photoalignment layer in a bound-bind structure.
US08609320B2 Resist composition, method of forming resist pattern, polymeric compound and compound
A resist composition, a method of forming a resist pattern using the resist composition, a novel polymeric compound and a compound useful as a monomer for the polymeric compound, the resist composition including a base component (A) that exhibits changed solubility in a developing solution under action of acid and an acid generator component (B) that generates acid upon exposure, the base component (A) containing a resin component (A0) including a structural unit (a0) represented by general formula (a0) shown below in which A represents a divalent linking group; and R1 represents a hydrogen atom or a hydrocarbon group of 1 to 6 carbon atoms which may have a substituent.
US08609319B2 Radiation-sensitive resin composition and resist film formed using the same
A radiation-sensitive resin composition that includes (A) a polymer that includes a repeating unit (a1) and a fluorine atom, the repeating unit (a1) including a group shown by the following formula (1) or (2), the radiation-sensitive resin composition including the polymer (A) in an amount of 0.1 mass % or more and less than 20 mass % based on the total amount of polymers included in the radiation-sensitive resin composition.
US08609316B2 Method for manufacturing capsule toner
A method for manufacturing a capsule toner having improved preservability with no deterioration in low-temperature fixability is provided. The method for manufacturing a capsule toner includes a mixed fine resin particle adhering step of adhering mixed fine resin particles including crystalline polyester fine resin particles and amorphous fine resin particles to surfaces of toner base particles to form mixed fine resin particle-adhered particles, a spraying step of spraying a mixed solution of a liquid for plasticizing the toner base particles and the mixed fine resin particles and a crystal nucleating agent, while fluidizing the mixed fine resin particle-adhered particles, and a film-forming step of making a film of the mixed fine resin particles by impact force so that the film is a resin coating layer on the surfaces of the toner base particles.
US08609315B2 Transparent toner, image forming method, and toner set
A transparent toner includes toner particles having a volume average particle diameter in the range of 18 μm to 28 μm, and satisfying formulae (1) and (2): 0.1≦Ntb/Nta×100≦2.5  (1) 0≦Ntc/Nta×100≦1.0  (2) Nta is the number of particles under the measurement conditions satisfying 0.5 μm≦circle-equivalent diameter≦200 μm, and 0.40≦circularity≦1.00; Ntb is the number of particles under the measurement conditions satisfying 0.5×Dta (μm)≦circle-equivalent diameter≦2.5×Dta (μm), and 0.60≦circularity≦0.90; and Ntc is the number of particles under the measurement conditions satisfying 2.5×Dta (μm)≦circle-equivalent diameter≦200 μm, and 0.40≦circularity≦1.00; Dta is the average circle-equivalent diameter under the measurement conditions satisfying 0.5μm≦circle-equivalent diameter≦200 μm, and 0.40≦circularity≦1.00.
US08609313B2 Toner and method for producing toner
A toner containing a resin binder and a colorant, wherein the resin binder contains a crystalline resin and an amorphous resin, the crystalline resin containing a composite resin containing: a polycondensation resin component obtained by polycondensing an alcohol component containing an aliphatic diol having 2 to 10 carbon atoms, and a carboxylic acid component containing an aromatic dicarboxylic acid compound, and a styrenic resin component, and the amorphous resin containing a polyester obtained from an alcohol component containing an aliphatic diol in an amount of 60% by mol or more, and a carboxylic acid component. The toner of the present invention is suitably used in, for example, the development of a latent image formed in electrophotography, electrostatic recording method, electrostatic printing method or the like.
US08609310B2 Electrophotographic photoreceptor, process cartridge, and image forming apparatus
An electrophotographic photoreceptor has at least an electroconductive substrate, and a photosensitive layer formed on or above the electroconductive substrate, wherein an outermost layer of the photoreceptor is a cured membrane of a composition containing at least one compound (a) having in a single molecule thereof a charge transporting skeleton and a chain polymerizable functional group, and at least one thermopolymerizable or photopolymerizable silicone polymeric radical polymerization initiator (b).
US08609309B2 Electrophotographic photoreceptor and image-forming apparatus
To provide an electrophotographic photoreceptor having a high sensitivity, a good balance of various electric properties such as chargeability and residual potential, a good stability of the coating solution, and an excellent light resistance.An electrophotographic photoreceptor comprising an electroconductive support having thereon a photosensitive layer, wherein the photosensitive layer contains a compound represented by the following formula (1): (wherein R1 represents a group having a chiral center, R2 represents a hydrogen atom, an alkyl group which may have a substituent, or an aryl group which may have a substituent, R3 and R4 each independently represents an alkylene group which may have a substituent, or an arylene group which may have a substituent, and R5, R6, R7 and R8 each independently represents an alkyl group which may have a substituent, or an aryl group which may have a substituent, and at least one member of R5 to R8 is an aryl group having a substituent).
US08609307B2 Thin film evaluation method, mask blank, and transfer mask
Provided is a thin film evaluation method for a transfer mask which is adapted to be applied with ArF excimer laser exposure light and comprises a thin film formed with a pattern on a transparent substrate. The method includes intermittently irradiating pulsed laser light onto the thin film to thereby evaluate the irradiation durability of the thin film.
US08609304B2 Method of manufacturing a transfer mask and method of manufacturing a semiconductor device
An internal defect or the like of a transfer mask is detected using transmitted light quantity distribution data of an inspection apparatus. Using a die-to-die comparison inspection method, inspection light is irradiated to a first region of a thin film to obtain a first transmitted light quantity distribution, the inspection light is also irradiated to a second region of the thin film to obtain a second transmitted light quantity distribution, a predetermined-range difference distribution is produced by plotting coordinates at which difference light quantity values calculated from a comparison between the first transmitted light quantity distribution and the second transmitted light quantity distribution are each not less than a first threshold value and less than a second threshold value, and a selection is made of a transfer mask in which a region with high density of plotting is not detected in the predetermined-range difference distribution.
US08609300B2 Method of making holographic recording materials and articles formed thereby
A method of manufacturing an article for display of a holographic image is described that includes thermally fusing a holographic recording medium containing a photochemically active dye dispersed in a transparent thermoplastic polymer binder to another layer or material; and then exposing the holographic film to intersecting beams of coherent light to form a holographic image therein formed by photoreacted areas of the photochemically active dye and unreacted areas of the photochemically active dye.
US08609296B2 Processing methods and systems for assembling fuel cell perimeter gaskets
A method and apparatus for making fuel cell components via a roll to roll process are described. Spaced apart apertures are cut in first and second gasket webs that each include adhesives. The first and second gasket webs are transported to a bonding station on conveyers. A membrane web that includes at least an electrolyte membrane is also transported to the bonding station. At the bonding station, a gasketed membrane web is formed by attaching the first and second gasket webs to the membrane web. The first gasket web is attached to a first surface of the membrane web via the adhesive layer of the first gasket web. The second gasket web is attached to a second surface of the membrane web via the adhesive layer of the second gasket web.
US08609295B2 Solid-electrolyte fuel cell and stack structure
For an enhanced rigidity and suppressed occurrences of stress concentration, a solid-electrolyte fuel cell is configured with simplex cells, a metallic separator of a circular thin-sheet form having a gas introducing port and gas discharging ports in the central portion, and cell mounting parts for the simplex cells to be fixed thereto, another metallic separator of a circular thin-sheet form having a gas introducing port and gas discharging ports in the central portion, the separators defining a space in between, and a pair of flow channel members accommodated in the space and pressed to be brought into abutment, for communication of their channels with the gas introducing ports and the gas discharging ports to effect gas supply and gas discharge to and from the space, either flow channel member being joined, within the space, to one separator.
US08609292B2 Fuel cell system
A basic injection time of an injector is obtained from an FC current detected in step S1. The basic injection time based on the FC current is multiplied by a predetermined correction coefficient for correction (learning), and the thus obtained value is re-defined as the basic injection time to obtain an injection time feedforward term (F/F term) to be obtained finally. The correction coefficient K is set by obtaining a flow rate characteristic per unit drive time of the injector in accordance with the relation between a total drive time and a total injection quantity of the injector until an FC inlet pressure on the anode side of a fuel cell reaches a predetermined target pressure by increasing the FC inlet pressure to the target pressure at a system start. The correction coefficient K is updated every system start.
US08609291B2 Fuel cell module including heating insulator with opening
A fuel cell configuration operable to provide a more uniform heat distribution within the fuel cell configuration is disclosed. A reactant gas, liquid or suspended solid (slurry) is circulated through the fuel cell configuration in such a manner that inherently hotter portions of the fuel cell are cooled. The more uniform heat distribution can enhance fuel cell life and operating characteristics.
US08609288B2 Water management in fuel cells
An electrochemical fuel cell having an anode, an ion transfer membrane and a cathode has liquid water delivered to the fluid flow channels within the cathode so as to maintain a relative humidity of 100% throughout the fluid flow channels. A calibration method and apparatus is described for determining an optimum quantity or range of quantities of liquid water to be delivered to the cathode fluid flow channels under varying operating conditions. An operating method and apparatus is described that ensures an optimum quantity of liquid water is delivered to the cathode fluid flow channels under varying operating conditions.
US08609287B2 Polyether-functionalized redox shuttle additives for lithium ion batteries
Compounds may have general Formula I, II, or III: where R1, R2, R3, and R4 are independently H, F, Cl, Br, CN, NO2, a alkyl group, a haloalkyl group, a phosphate group, a polyether group; or R1 and R2, or R3 and R4, or R2 and R3 (in the case of Formula II) may join together to form a fused ring on the benzene ring; and X and Z are independently a group of Formula A: where R5 and R6 and R7 are independently H, F, Cl, Br, CN, NO2, a alkyl group, a haloalkyl group, a phosphate group, or a polyether group; R7 is H, F, Cl, Br, CN, NO2, a alkyl group, a haloalkyl group, a phosphate group, or a polyether group; n is an integer from 1 to 8; and m is an integer from 1 to 13. Such compounds may be used as redox shuttles in electrolytes for use in electrochemical cells, batteries and electronic devices.
US08609281B2 Electrolytic manganese dioxide, positive electrode active material, and battery
Electrolytic manganese dioxide characterized by having a surface sulfate (SO4) content of smaller than 0.10% by weight and a JIS-pH value, as measured according to JIS K1467, of at least 1.5 but smaller than 3.5, preferably at least 2.1 but smaller than 3.2 is provided. Preferably 3% to 25% in number of the fine particles of the manganese dioxide have a particle diameter of not larger than 1 μm. A battery provided with a cathode made from the electrolytic manganese dioxide as active material exhibits good high-rate discharge characteristics and good resistance to metal corrosion.
US08609278B2 Battery cell
An electrochemical cell includes a cell element comprising at least one electrode. A portion of the at least one electrode extends outward from an end of the cell element. The portion of the at least one electrode is folded onto itself to provide a coupling surface for conductive connection to a terminal of the electrochemical cell.
US08609276B2 Battery pack
A battery pack comprises a battery module disposed inside a case, the battery module including a plurality of battery units, each including first and second lead tabs which protrude outside of each battery unit and which have bent portions. An insulation plate includes a plurality of ribs, wherein the bent portions of the lead tabs extend over the ribs, and a plurality of bus bars are disposed over the lead tabs and electrically connect the battery units serially with each other, the bus bars being fixed to the ribs.
US08609275B2 Connective structure between a battery cell and a connecting bar of a battery pack
A battery pack having an improved a coupling force between a battery cell and a connecting bar of a connecting structure. The connecting structure includes at least one battery cell, a connecting bar electrically connected to the battery cell, a welding region formed at a connecting area of the battery cell and the connecting bar, and an anisotropic conductive film formed at the outer periphery of the welding region and connecting the battery cell and the connecting bar to each other.
US08609273B2 Anode coated with lithium fluoride compounds, method for preparing the same, and lithium secondary battery having the same
An anode for a lithium ion secondary battery includes an anode, and a LiF-based coating layer formed with LiF-based particles on a surface of the anode. The LiF-based coating layer has a thickness of 0.05 to 1 μm. The anode allows the LiF-based coating layer created by side reaction of LiPF6 during a battery charging/discharging process to be relatively uniformly formed on the anode surface, thereby elongating the life cycle of a lithium ion secondary battery.
US08609270B2 Iron-sulfide redox flow batteries
Iron-sulfide redox flow battery (RFB) systems can be advantageous for energy storage, particularly when the electrolytes have pH values greater than 6. Such systems can exhibit excellent energy conversion efficiency and stability and can utilize low-cost materials that are relatively safer and more environmentally friendly. One example of an iron-sulfide RFB is characterized by a positive electrolyte that comprises Fe(III) and/or Fe(II) in a positive electrolyte supporting solution, a negative electrolyte that comprises S2− and/or S in a negative electrolyte supporting solution, and a membrane, or a separator, that separates the positive electrolyte and electrode from the negative electrolyte and electrode.
US08609267B2 Electrochemical cell with an electrolyte flow, comprising through-electrodes and production method
An electrochemical cell comprises an inlet and an outlet for an electrolyte flow, and two unipolar electrodes. Each electrode comprises a structure with a network of through-passages, surrounded by a solid frame. The electrolyte enters via inlets, circulates via the passages of the electrodes, passes through the space between the electrodes and leaves via an outlet. The structure and the frame are based on carbon.
US08609262B2 Structure and method to fabricate high performance MTJ devices for spin-transfer torque (STT)-RAM application
A STT-RAM MTJ is disclosed with a MgO tunnel barrier formed by natural oxidation and containing an oxygen surfactant layer to form a more uniform MgO layer and lower breakdown distribution percent. A CoFeB/NCC/CoFeB composite free layer with a middle nanocurrent channel layer minimizes Jc0 while enabling thermal stability, write voltage, read voltage, and Hc values that satisfy 64 Mb design requirements. The NCC layer has RM grains in an insulator matrix where R is Co, Fe, or Ni, and M is a metal such as Si or Al. NCC thickness is maintained around the minimum RM grain size to avoid RM granules not having sufficient diameter to bridge the distance between upper and lower CoFeB layers. A second NCC layer and third CoFeB layer may be included in the free layer or a second NCC layer may be inserted below the Ru capping layer.
US08609259B2 Organic electroluminescent device and platinum compound
An organic electroluminescent device, which has a pair of electrodes, and at least one organic layer including a luminescent layer between the electrodes, wherein the organic layer contains at least one compound of formula (1): wherein Q11 are atoms for forming a nitrogen-containing hetero ring; Z11 to Z13 each independently represents CR, wherein R represents a substituent, CH or N; n11 is 0 or 1; M11 is a metal or boron ion that may further have a ligand(s); and a compound of formula (6): wherein R63 to R66 each is a hydrogen atom or a substituent; X61 to X64 and Z61 to Z66 each is CR, wherein R represents a substituent, CH or N.
US08609256B2 Nickel-gold plateable thick film silver paste
Described are LTCC devices, with external silver containing electrical contacts, that are sequentially plated with a nickel containing metal and a gold containing metal, with a defined silver paste composition for manufacture.
US08609255B2 Polyester film, and solar-cell back sheet and solar-cell using the same
A polyester film has a laminate structure including a polyester layer (layer P1) containing a crystalline polyester and inorganic particles and a polyester layer (layer P2) containing a crystalline polyester, inorganic particles, and an antihydrolysis segment, wherein the content (Wa2) of the inorganic particles in the layer P2 is at least 10 mass % of the layer P2, the difference between the content (Wa2) (mass %) of the inorganic particles in the layer P2 and the content (Wa1) (mass %) of the inorganic particles in the layer P1, Wa2−Wa1, is 5 to 25 mass %, and the content (Wb2) of the antihydrolysis segment in the layer P2 is 0.02 to 1.5 mass % of the layer P2.
US08609253B2 Coated article and method for making the same
A coated article includes a substrate and a thermochromic coating formed on the substrate. The thermochromic coating is a vanadium dioxide layer co-doped M and R, where M is two or more elements selected from a group consisting of titanium, niobium, molybdenum and tungsten, R is one or more elements selected from a group consisting of rhodium, palladium and ruthenium.
US08609252B2 Rubber composition
A rubber composition comprises a rubber component, sulfur and a sulfeneamide base vulcanization accelerator represented by the following Formula (I), and has an excellent adhesive property with metal such as a steel cord without bringing about problems such as deteriorating in the physical properties and blooming of rubber after vulcanization. (wherein R1 represents a branched alkyl group having 3 to 12 carbon atoms; R2 represents a linear alkyl group having 1 to 10 carbon atoms or a branched alkyl group having 3 to 10 carbon atoms; x represents an integer of 1 or 2, and n represents an integer of 0 or 1).
US08609250B2 Device housing and method for making same
A device housing includes a substrate, a metallic coating formed on the substrate by vacuum sputtering or vacuum vapor deposition, and a self-repairing coating formed on the metallic coating. The self-repairing coating substantially includes trimethylene oxide and polyhydric alcohols.
US08609245B2 Semiconductor nanocrystals and preparation methods thereof
A nanocrystal includes a core including a Group III-V semiconductor and a transition metal alloyed with the Group III-V semiconductor, wherein the transition metal is present at a higher molar concentration in an outermost surface layer of the core than in a central portion of the core.
US08609243B2 Pressure-sensitive adhesive optical film and image display
A pressure-sensitive adhesive optical film includes: an optical film; and a pressure-sensitive adhesive layer laminated on at least one side of the optical film with an anchor layer interposed therebetween, wherein the anchor layer has a thickness of 5 to 300 nm, the pressure-sensitive adhesive layer has a thickness of 5 to 50 μm, at least one of the anchor layer and the pressure-sensitive adhesive layer is made from a ammonia-containing water-dispersible material, the layer made from the ammonia-containing water-dispersible material contains ammonia in an amount of 10 ng or more per 1 cm2 of the pressure-sensitive adhesive optical film, wherein the amount is a measurement derived from the layer, and the pressure-sensitive adhesive optical film contains ammonia in a total amount of 2000 ng or less per 1 cm2 of the pressure-sensitive adhesive optical film. The pressure-sensitive adhesive optical film has good appearance and high durability.
US08609239B2 Release film, ceramic part sheet and process for their production, and process for production of ceramic part
A release film 10 having a base film 12 and a polymer layer 14 formed on one side of the base film 12, wherein the polymer layer 14 includes a layer containing a cured (meth)acrylate component and a film containing a silicone polymer component covering part of the surface on the side of the layer opposite the base film side, and wherein the silicone polymer component is a modified silicone oil polymer that has been modified with a (meth)acryloyl and/or vinyl group.
US08609236B2 Adhesive for polarizing plate, polarizing plate, manufacturing method therefor, optical film and image display
An adhesive of the invention is used for polarizing plate to provide a transparent protective film on at least one side of a polarizer and comprises a resin solution comprising a polyvinyl alcohol-based resin, a crosslinking agent and a colloidal metal compound with an average particle size of 1 nm to 100 nm, wherein 200 parts by weight or less of the colloidal metal compound is added to 100 parts by weight of the polyvinyl alcohol-based resin. The adhesive for polarizing plate can reduce the occurrence of knicks.
US08609235B2 Porous ceramic material and method of producing the same
Provision of a porous ceramic material which rapidly induces bone tissue formation and has practical strength.A porous ceramic material 11 having substantially unidirectionally oriented pores 12, a porosity of 40-90%, and an average open area of one pore of 0.05×10−3-50×10−3 mm2 both in a first sectional surface perpendicular to the pore 12 orientation direction and a second sectional surface parallel to the first sectional surface and 5 mm distant from the first sectional surface in the pore 12 orientation direction. Using the material 11, when a cylindrical test piece (diameter 3 mm×height 5 mm, the pore 12 array direction as a height direction) made of the material is dipped in polyethylene glycol up to 1 mm from one end thereof, polyethylene glycol permeates through the whole test piece preferably within 30 seconds.
US08609234B2 Fluoropolymer containing laminates
The multilayer film serves as a laminate. In some embodiments, the film is a multilayered structure that, in its base form, encompasses an intermediate layer with first and second outer layer affixed to opposing sides of the intermediate layer. In some embodiments, the first outer layer is a semi-crystalline fluoropolymer. In some embodiments, the intermediate layer includes a polyester and the second outer layer is an olefinic polymer.
US08609229B2 Glass/resin laminate, and electronic device using same
The present invention relates to a glass/resin laminate containing a glass substrate and a resin layer, in which the resin layer contains a polyimide obtained by condensation-polymerization of an aromatic diamine having a benzoxazole structure with an aromatic tetracarboxylic anhydride, the difference in the average linear expansion coefficient at 25 to 300° C. between the glass substrate and the resin layer is from −100×10−7 to +100×10−7/° C., and at least one outermost layer of the laminate is the glass substrate.
US08609228B2 High performance sealable coextruded biaxially oriented polypropylene film
A multilayer biaxially oriented polypropylene film is disclosed which comprises at least three layers. The first layer is an outer layer comprising a first polymer which is a homopolymer polypropylene resin having a melting point of at least 155° C. The second layer is a core layer, having a melting point greater than 150° C. The core layer includes a blend comprising a second polymer which is a polypropylene homopolymer having a melting point of at least 155° C. and a third polymer having a melting point no greater than 145° C. The second polymer comprises from 20% to 80% by weight of the core layer while the third polymer comprises from 80% to 20% by weight of the core layer. The last required layer in the film is a sealant layer. The sealant layer comprises a fourth polymer having a melting point no greater than 145° C.
US08609226B2 High strength low density multi-purpose panel
A high strength low density panel. The panel is formed of sections. Each section will preferably have the shape of a cuboid or a prism. At least one face of each section is provided with a buttress. The sections are preferably inverted relative to each other. The sections are configured so that they share sidewalls with each adjacent section, which creates a series of braces extending across the panel. The prismatic sections are paired to form cuboids. These cuboids have a diagonal internal wall. The internal walls of the cuboids align in the panel to create braces that extend across the panel at an angle to the other braces. Finally, all of the buttresses are configured so that the buttress of adjacent and cater-corner sections meet their respective common section corners at substantially the same point.
US08609224B2 Fastening assembly
A fastening assembly includes a magnesium alloy member, a metallic sheet defining a through hole, a metallic bolt, and a nut positioned on an end of the bolt and attached to the metallic sheet. The magnesium alloy member includes a magnesium alloy base, and at least one resin coating layer formed in at least one portion of the magnesium alloy base. The magnesium alloy member defines a through hole penetrating through the magnesium alloy base and the at least one resin coating layer. The metallic bolt extends through the through holes of the magnesium alloy base and the metallic sheet. An inner width of the through hole of the magnesium alloy member is greater than a width of the metallic bolt, a material of the metallic bolt is different from a material of the magnesium alloy base or a material of the metallic sheet.
US08609219B2 Selectively coupled fibers in composites
A composite article may include a plurality of fibers embedded within a matrix. The fibers may include a first fiber and a second fiber which may be oriented in substantially parallel relation to one another. The first and second fibers may be connected to one another at one or more connection sites.
US08609217B2 Optical recording media with specific vision label layer
An optical recording medium is equipped with a light transmitting layer to have visual effects. Patterns with different visual effects can be printed on the upper and low surfaces of the light transmitting layer. Alternatively, visual effects can be presented by directing light out of an upper light grating from a low printing layer. The optical recording medium can not only record information but also present visual effects.
US08609215B2 Irregular tessellated building units
A surface covering comprises multiple units adapted to mate with one another and cover a surface. Each said unit comprises at least one primary rotational tessellation element that defines the sides of the unit, has an irregular configuration, includes a face having molded surface irregularities or variations therein, and has at least two pairs of irregularly shaped sides. Preferably, gaps of variable width are defined between visible edges of adjacent units in the surface covering. The surface covering has a natural appearance such that a repeating pattern is not readily apparent. A structural wall unit system is also provided.
US08609213B2 Waterproofing Membrane
Disclosed are waterproofing membranes comprising the following laminated layers: layer A comprising a waterproofing adhesive; layer B comprising a carrier sheet; layer C comprising a releasable bonding material; and layer D comprising a protective coating; wherein (i) the laminated layers are arranged in the sequential order A-B-C-D; or (ii) the laminated layers are arranged in the sequential order B-C-D-A; or (iii) the laminated layers are arranged in the sequential order C-D-A-B. The membrane does not include a removable release sheet that is typically used to prevent the adhesive from adhering to the carrier sheet or other portion of the membrane when the membrane is rolled up. Also disclosed is a method of making the aforementioned membrane. Preferably, layer C will comprise a water soluble polymer, an alkali soluble polymer, or a homopolymer or copolymer of polyvinyl acetate.
US08609212B2 Security arrangement
A security label (310) comprises a first layer (114) of a non-affixing polymeric coating printed on a coating receiving surface (362) of a carrier film substrate (112). Affixing portions (121) of a second layer (118) adhere to the carrier film substrate (112) via affixing regions (116) defined by the first layer (114). The first layer (14) is less adherable to the carrier film substrate (12) than the second layer (18), so that, in use, when the carrier film substrate (12) is removed from the first layer (14), the affixing portions (121) of the second layer (18) remain adhered to the carrier film substrate (12) and are disassociated from an adhesive material layer (120), and those portions of the second layer which are not affixing portions remain associated with the adhesive material layer (120) and are disassociated from the carrier film substrate (112).
US08609211B2 Label that is removable or having a removable section
A label that is removable from the article with which it is associated, or includes a removable section thereof, and includes only a single substrate. The substrate has a front side and a back side, and an ink disposed on the back side of the substrate, which remains with the substrate during removal of the substrate, or a section thereof, from an article. The label further includes an abhesive disposed adjacent the ink on the back side of the substrate. The label may have at least one set of perforations to provide a removable section of the label. These perforations may be provided by an apparatus for providing consistent perforations.
US08609208B2 Optically isotropic liquid crystal medium and optical device
A liquid crystal medium having an optically isotropic liquid crystal phase is described, which has stability to heat, light and so on, a broad temperature range of liquid crystal phase, a large optical anisotropy and a large dielectric anisotropy. A liquid crystal composition is described, which includes an achiral component T and a chiral dopant and exhibits an optically isotropic liquid crystal phase. The achiral component T contains, as its first component, at least one compound selected from compounds represented by formula (1), wherein R1 is C1-10 alkyl, the rings A1 to A6 are 1,4-phenylene, Z1 to Z7 are single bonds, Y1 and Y2 are fluorine; X1 is halogen, and i, j, k, m, n, p and q are independently 0 or 1.
US08609206B2 Continuous or discrete metallization layer on a ceramic substrate
Surface metallization technology for ceramic substrates is disclosed herein. It makes use of a known phenomenon that many metal—metal oxide alloys in liquid state readily wet an oxide ceramic surface and strongly bond to it upon solidification. To achieve high adhesion strength of a metallization to ceramic, a discrete metallization layer consisting of metal droplets bonded to ceramic surface using metal—metal oxide bonding process is produced first. Next, a continuous metal layer is deposited on top of the discrete layer and bonded to it using a sintering process. As a result a strongly adhering, glass-free metallization layer directly bonded to ceramic surface is produced. In particular, the process can be successfully used to metalize aluminum nitride ceramic with high thermal and electrical conductivity copper metal.
US08609201B2 Infrared curing process for touch panel manufacturing
An infrared energy oxidizing and/or curing process includes an infrared oxidation zone having an infrared energy source operable to emit infrared energy that oxidizes a conductive thin film deposited or established on a glass substrate to establish a light transmissive or transparent conductive thin film for manufacturing of a touch panel. Optionally, the infrared energy curing process provides an in-line infrared energy curing process that oxidizes the conductive thin film on the glass substrate as the glass substrate is moved past the infrared energy source. Optionally, the infrared energy curing process bonds a thick film silver frit electrode pattern to the conductively coated glass substrate. Optionally, the infrared energy curing process reduces the transparent conductive thin film.
US08609196B2 Spallation-resistant multilayer thermal spray metal coatings
A wear- and corrosion-resistance coating over a metal substrate having a first-layer carbide material, a second metal coating layer over the first metal coating layer, and a surface metal coating layer over the second metal coating layer; and thermal spray method for applying the coating.
US08609195B2 Process for the demulsifying cleaning of metallic surfaces
The demulsifying cleaning of metallic surfaces which may be contaminated with oil(s) with at least one further nonpolar organic compound, with fat(s), with soap(s), with particulate dirt or with at least one anionic organic compound using an aqueous, alkaline, surfactant-containing bath solutions.
US08609194B2 Method and apparatus for composition coating for enhancing white light scanning of an object
The invention is directed to a method and apparatus for pretreatment an object to be white light scanned to enable accurate and consistent scanning. In those instances where the object part has a reflective or refractive surface or is made from a material having translucent or transparent properties the object must be pretreated to ensure accurate data collection during the scanning process. The object is coated with a composition forming a thin and uniform film of non destructive material coating to enhance the surface contrast characteristics for the mono-chromatic fringe pattern employed in the white light scanning process.
US08609191B2 Air-permeable filtration media, methods of manufacture and methods of use
The present invention provides an air-permeable filtration media that includes an air-permeable backing and an adsorbent. The adsorbent is at least partially embedded in the air-permeable backing. The present invention also provides a method of manufacturing an air-permeable filtration media. The present invention also provides a method of substantially removing contaminants form air, employing the air-permeable filtration media.
US08609190B2 Method for producing a getter device
The invention relates to a method for producing a getter device (1), wherein a getter material (3) is introduced into a container (2) and the getter material (3) is heated to a temperature under reduced pressure so that getter material (3) is deposited on an inside of the container (2). In order to be able to provide a getter device (1) in a short time that has a high getter capacity, it is provided according to the invention that during a deposition of getter material (3), the container (2) is moved relative to a zone (4) in which the container (2) is cooled.
US08609189B2 Method of forming carbon nanotubes from carbon-rich fly ash
The method of forming carbon nanotubes from carbon-rich fly ash is a chemical vapor deposition-based method for forming carbon nanotubes from recycled carbon-rich fly ash. The method includes first ultrasonically treating the carbon-rich fly ash to produce an ultrafine powdered ash, and then reacting the ultrafine powdered ash in a low pressure chemical vapor deposition reactor to form the carbon nanotubes. The ultrasonic treatment of the carbon-rich fly ash includes the steps of dissolving the carbon-rich fly ash in water to form a solution, then sonicating the solution, separating the ultrafine powdered ash from the solution, and finally drying the ultrafine powdered ash. The method provides for total conversion of the carbon-rich fly ash to carbon nanotubes having a variety of differing diameters and lengths, including multi-walled carbon nanotubes with a high degree of wall graphitization and C═C double bonds stretching at 1635 cm−1.
US08609188B2 Surface modification of nano-diamonds and manufacturing method thereof
The invention is related to a technique that grafts polymer onto a surface of nano-diamonds, and the invention further provides applications relating to modification and dispersion of the nano-diamonds. The features of the technique are single step, one pot, low cost, and high yield, and therefore the technique has high potential for commercialization. The invention also provides a method for graphitizing monocrystalline nano-diamonds and polycrystalline nano-diamonds. Accordingly, the technique of modifying and polymer grafting can be used not only on ultra disperse diamonds but also on monocrystalline nano-diamonds with graphitized surfaces and polycrystalline nano-diamonds with graphitized surfaces.
US08609185B2 Method of repairing an aluminide coating on an article
A method of locally repairing an aluminide coating (50) on a gas turbine engine nozzle guide vane (26) or a turbine blade (30,30B) comprises removing a damaged portion of the aluminide coating (50) from a portion (53) of the surface of the article. Any oxidised layer (54) is removed from the portion (53) of the surface of the article. Stoichiometric amounts of nickel and aluminium are placed on the portion (53) of the surface of the article using at least one foil (57). The stoichiometric amounts of nickel and aluminium are heat treated to form an aluminide patch coating (50B) on the portion (53) of the surface of the article and to bond the aluminide patch coating (50B) to the portion (53) of the surface of the article and to the aluminide coating (50) surrounding the aluminide patch coating (50B). The advantage is that the aluminide coating (50) surrounding the aluminide patch coating (50B) is not over aluminised.
US08609184B2 System and method for depositing a lubricant material on a hydrophobic surface
A system and method for corrosion problems in magnetic media resulting from moisture penetrating through the carbon layer into the magnetic layer by diffusion or other methods are overcome by processing the carbon overcoat to stop and/or inhibit the moisture penetration. The process involves removing moisture channels from protective overcoats of thin film magnetic media by irradiating the protective overcoat with ultraviolet (UV) radiation in an inert hydrophobic chemical environment. Afterwards, the thin film magnetic media can be removed into ambient atmosphere where it is coated with a lubricant.
US08609183B2 Method for making sulfur-graphene composite material
A method for making sulfur-graphene composite material is disclosed. In the method, a dispersed solution including a solvent and a plurality of graphene sheets dispersed in the solvent is provided. A sulfur-source chemical compound is dissolved into the dispersed solution to form a mixture. A reactant, according to the sulfur-source chemical compound, is introduced to the mixture. Elemental sulfur is produced on a surface of the plurality of graphene sheets due to a redox reaction between the sulfur-source chemical compound and the reactant, to achieve the sulfur-graphene composite material. The sulfur-graphene composite material is separated from the solvent.
US08609181B2 Light emitting device and method for fabricating light emitting device
It is an object of the present invention to provide a method for fabricating a light emitting device, in which brightness gradient due to potential drop of a counter electrode can be prevented from being observed and an auxiliary electrode can be formed without increasing the number of steps, even when the precision of a light emitting device is improved. It is another object of the invention to provide a light emitting device fabricated according to the method. The light emitting device has a light emitting element and an auxiliary electrode in each pixel. The light emitting element includes a first electrode, a second electrode, an electroluminescent layer provided between the first and the second electrodes. Further, the first electrode is overlapped with the electroluminescent layer and the second electrode formed over an insulating film by means of a first opening formed in the insulating film. Still further, the auxiliary electrode is overlapped with the second electrode by means of a second opening formed over the second insulating film.
US08609179B2 High throughput automated apparatus, method and system for coating ears of corn
Apparatuses, methods and systems for applying a coating to an ear of corn in a high throughput manner are disclosed. The system includes means for moving the ear of corn through the system and means for coating the ear of corn with a coating while passing through the system. The apparatus includes a carrying position for an ear of corn, an automated line having a plurality of the carrying positions, and an automated coating station adapted to apply a coating to the ear of corn on the automated line. The method includes staging a plurality of ears of corn on an automated line, passing the automated line through an ear coating process, and coating the plurality of ears of corn with a coating.
US08609174B2 Method for producing a soluble cocoa product from cocoa powder
The present invention relates to a method for producing a soluble cocoa product from cocoa powder. The present invention further relates to cocoa products obtained by the present method and uses thereof. The present invention is also directed to a cocoa-derived material comprising a soluble cocoa powder and a cocoa extract, wherein said extract comprises more than 25 wt % based on the extract of polyphenols. The cocoa-derived material can be a syrup, a ready to use beverage or a powder composition. The invention also relates to uses of this cocoa-derived material for preparing carbonated beverages containing cocoa. The invention further relates to a carbonated beverage comprising said cocoa-derived material and to methods for preparing such cocoa-derived materials and beverages. The invention also provides an ice cream comprising a cocoa powder, and in particular to an ice cream comprising up to 15 wt % of a soluble cocoa powder, wherein said cocoa powder has a solubility in water of at least 50% at a temperature of less than 10° C. The invention further relates to a method for preparing such ice cream and the use thereof in food products.
US08609171B2 Circumferential pasteurizer
Circumferential pasteurizers and related methods are disclosed. A circumferential pasteurizer includes a vessel having an inner guide surface, a thermal medium inlet disposed on a first side of the vessel, a thermal medium outlet disposed on a second side of the vessel, a food product inlet disposed on the second side of the vessel, a food outlet disposed on the first side of the vessel, and a rotating paddle wheel suspended for rotation in the vessel. The paddle wheel includes a hub and a plurality of paddles distributed around the hub and extending outwardly therefrom to adjacent the vessel inner guide surface to form food receiving pockets extending the length of the hub. The paddle wheel conveys the food product from the food product inlet to the food product outlet along the vessel inner guide surface and counter to the flow of the thermal medium.
US08609167B2 Method of operating commercial cooking equipment, in particular, also cooking equipment for carrying out the method
The disclosure is a method of operating a commercial cooking equipment, in particular a hot-air steamer or fan oven, comprising the following method steps: a) selecting a product requiring cooking having an assigned cooking program or selecting at least one cooking parameter having assigned selectable products; b) loading the cooking equipment with a selected product; c) starting the associated cooking program; d) displaying the name of the program and at least the remaining cooking time; e) associating in automated manner further products or cooking programs that fit in with the cooking program of the first selected product in dependence on cooking parameters, in particular, the cooking temperature and/or the cooking humidity and/or the fan speed; f) displaying the selectable products or selectable cooking programs; g) selecting, on demand, a further product which matches the first product in accordance with the associating process; h) loading the cooking equipment with the further product; i) starting the assigned cooking program; j) displaying the name of the program and at least the remaining cooking time for the further product; k) if necessary, repeating the steps g) to j); and l) removing the product from the cooking equipment at the expiry of the respective cooking time.
US08609165B1 Dietary supplement for optimizing glucose levels, increasing energy, and improving general health
A dietary supplement can optimize glucose levels, increase energy, and provide other health benefits including combinations of alpha lipoic acid, vanadium, zinc, vitamin C and biotin.
US08609164B2 Uniformly moist cheese
The invention provides moist cheeses of uniform composition that are readily and inexpensively made by acidifying milk prior to beginning the cheese making process.
US08609160B2 Composition and method of treating lipid encapsulated virus infections
A method of treating a patient infected with a lipid encapsulated virus by administering to the patient about 1000 mg to about 5000 mg per day of a nutritional supplement having from about 40 to about 80 wt. % L-lysine, from about 20 to about 50 wt. % butylated hydroxytoluene and from about 1 to about 10 wt. % Echinacea. Administration of the nutritional supplement inhibits ulcer formation resulting from lipid encapsulated virus infections such as herpes simplex I and II infections.
US08609159B2 Immunostimulatory compositions and methods of use thereof
Immunostimulatory compositions and methods of use are described to either enhance or diminish the immune stimulation effects of a honey or honey isolate by recognition of the presence of type II arabinogalactan compounds and utilizing this knowledge to tailor the concentration of such compounds thereby adjusting the immune stimulation effects.
US08609157B2 Solvent-free process for obtaining phospholipids and neutral enriched krill oils
The invention discloses a new solvent-free process for obtaining phospholipids and neutral lipids enriched krill oils containing DHA and EPA poly-unsaturated fatty acids and astaxanthin. The process includes cooking fresh krill at high temperature-without agitation and or grinding; decanting the cooked krill for obtaining a partial de-fatted and de-watered solid and a liquid; squeezing the obtained solid to obtain a press liquid and a solid fraction; centrifuging the press liquid to obtain the phospholipids enriched krill oil; centrifuging of the decanter liquid obtained to obtain the neutral lipid enriched krill oil and stickwater.
US08609154B2 Anti-inflammatory cyclooxygenase inhibitors
Disclosed is a pharmaceutical composition including a therapeutic quantity of a COX-2 inhibitor having an IC50-WHMA COX-2/COX-1 ratio ranging from about 0.23 to about 3.33 with reduced gastrointestinal and cardiovascular toxicity. Also disclosed are methods for treating osteoarthritis, rheumatoid arthritis or acute pain with less side-effects and faster onset of action utilizing the disclosed pharmaceutical composition.
US08609152B2 Compositions and methods for extracting and using phytochemicals for the treatment of influenza
Methods and compositions for treating at least one symptom of a viral infection, said method of treatment comprising administering to a subject with a least one symptom of a viral infection an effective dosage unit of a composition comprising pomegranate extract. The compositions comprise pomegranate extract comprising polyphenols. The composition is produced by a process comprising providing one or more pomegranate solids selected from the group consisting of a pericarp, inner membrane and seeds, creating a mixture comprising said one or more pomegranate solids in an aqueous solution, heating said mixture to a temperature that permits enzyme catalysis of said pomegranate solids, and removing residual insoluble solid materials from said mixture to provide said pomegranate extract. Compositions containing the extract may be used as a food product, beverage, pharmaceutical preparations, nutritional supplements, vitamin supplements, food additives, and food supplements.
US08609149B2 Dilutable biocidal compositions and methods of use
The present technology, in general, relates to antimicrobial and biocidal compositions, for example bucket dilutable biocidal compositions, and the various applications and/or processes of utilizing them as hard surface disinfectants and/or cleaners. The biocidal composition of the present technology comprises hydrogen peroxide, a quaternary ammonium compound, an appropriate acid and an amine oxide in specific concentrations to provide a 5 minute or less microbial contact kill time for at least one biocidal target.
US08609147B2 Use of deuterium oxide for treatment of herpes virus-based diseases of the skin
The present invention relates to the use of deuterium oxide (D2O) for prevention and/or treatment of virus-based diseases of the skin, in particular herpes virus-based and verrucal virus-based diseases of the skin.
US08609145B2 Dispersible struvite particles
A water-dispersible particle is provided that includes struvite in an amount ranging from 5% to 99.9% by weight of the total dry weight of the particle. A binder component is present in an amount from 1% to 95% by weight. The struvite and the binder component on that contact with water causes particle dispersion into more than 100 pieces. A process for making a water-dispersible particle includes mechanical aggregation of a struvite into a pellet. A binder component is present in the particle in an amount ranging from 1% to 95% by weight. The struvite and the binder component are present in a form such that contact with water causes particle dispersion into more than 100 pieces. The particle is then dried and ready to be applied.
US08609141B2 Silver ion delivery platform
The present invention pertains to silver ion bearing carriers useful in treating monorrhagia of a mammalian uterus, comprising a physiologically inert, flexible earner, e.g., a coil, bearing a tissue cauterizing amount of a silver ion. Silver ions are delivered to the endometrium and cause necrosis of the endometrial tissue. The silver ions remaining within the uterine cavity can then be neutralized with a sodium chloride solution delivered to the uterus e.g., by catheter, and the carrier recovered from the uterus.
US08609136B2 Method and apparatus for forming delivery devices for oral intake of an agent
Provided are methods, systems and apparatuses for producing delivery devices, for example, for oral intake of an agent. The method can include assembling one or more layers including one or more materials with an agent or an agent-releasing formulation to form an intergraded device; folding the intergrated delivery device to form a folded integrated delivery device; and at least partially enclosing the folded delivery device to a form suitable for oral delivery.
US08609135B2 Anthracycline derivatives
Anthracycline derivatives are suitable for use in cancer therapy and diagnosis. These anthracycline derivatives can be radiolabelled and used as an imaging agent in cancer diagnosis. The radiolabelled anthracycline derivatives can also be used together with a drug delivery system, in particular including a two-step targeting strategy, for treating solid and disseminated tumors. These drug delivery system can advantageously be used for treatment and diagnosis of breast cancer.
US08609133B2 Porous structures and methods of use
The present invention provides porous structures that each comprise chitosan, alginate and divalent metal cations, wherein: (a) the chitosan is ionically linked to the alginate; and (b) the structure is porous and has a compressive yield strength of at least 0.35 MPa. The present invention also provides methods for making the porous structures, and methods for using the porous structures as substrates to grow living cells.
US08609132B2 Flow directing materials and systems
A flow directing material includes a substrate. The substrate includes a first region that exudes fluid under a compressive or tensile load and a second region that imbibes fluid under the compressive or tensile load. The first region has a first porosity and a first permeability and the second region has a second porosity and a second permeability. The first permeability and the second permeability are about 10−13 m2 to 105 m2. The first porosity and the second porosity are about 0.3 to about 0.7. The first porosity and the second porosity are at least about 5% different.
US08609131B2 Absorbent dressing comprising hydrophilic polymer prepared via Michael reaction
An absorbent dressing is described which comprises a crosslinked hydrophilic gel absorbent layer comprising a first component polymer comprising a plurality of polymerized monomer units having pendent hydrophilic groups, and pendent Michael donor groups; and a crosslinking agent comprising at least two Michael acceptor groups.
US08609127B2 Medical implant with bioactive material and method of making the medical implant
Embodiments of the invention include a medical device and a method of manufacturing a medical device having a porous scaffold in combination with a bioactive material. In some embodiments, particularly limited thicknesses of the bioactive material are applied within pores of the porous structure.
US08609125B2 Thermoplastic fluoropolymer-coated medical devices
A medical device provided with at least a partial surface coating of a thermoplastic copolymer of tetrafluoroethylene and perfluoroalkylvinylether that is free of cross-linking monomers and curing agents. The fluoropolymer coating is preferably an amorphous thermoplastic, is highly inert and biocompatible, has elastomeric characteristics that provide desirable mechanical properties such as good flexibility and durability. These characteristics allow the coating to be considered “functionally transparent” because it withstands mechanical deformations required for the assembly, deployment, expansion, and placement of medical devices, without any adverse effect on the mechanical and biological functionality of the coated device. Further, its inertness, derived from the perfluorocarbon structure, contributes to its functionally transparent nature. The coating can be provided with various liquid or solid additives, can be loaded with large quantities of additives including a wide range of therapeutic agents, and has excellent drug elution characteristics when elutable additives are used.
US08609122B2 Immobilized bioactive hydrogel matrices as surface coatings
The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate.
US08609121B2 Titanium dioxide photocatalytic compositions and uses thereof
Provided is a photocatalytic composition comprising zinc (Zn) doped titanium dioxide (TiO2) nanoparticles, wherein the ratio of titanium dioxide nanoparticles to zinc is from about 5 to about 150. The photocatalytic composition absorbs electromagnetic radiation in a wavelength range from about 200 nm to about 500 nm, and the absorbance of light of wavelengths longer than about 450 nm is less than 50% the absorbance of light of wavelengths shorter than about 350 nm. Further provided is a method for treating or preventing microbial diseases and infestations in a plant and a method for increasing crop yield of a plant by applying the photocatalytic compositions taught herein to the surface of a plant. Also provided is a method for treating microbial diseases on a surface by applying the photocatalytic compositions taught herein to a surface illuminated by artificial light.
US08609119B2 Active agent delivery and/or odor retentive composition and methods of use thereof
An active agent delivery and/or odor retentive composition including a surfactant and wax spheres formed from at least one of beeswax and soy wax and methods of use thereof. The composition is particularly useful in the cosmetics and medical industry for delivering/carrying a particular ingredient to one's skin, scalp or hair; for absorbing odor causing materials, such as fuel byproducts from a skin surface; and/or for providing exfoliating properties to the skin. The delivery system/carrying system is also useful in binding to certain nutritional materials, such as vitamins, minerals, antioxidants, and the like for ingestion and release into the body.
US08609118B2 Solid oil powders
The present invention relates in general to the field of oil powders. In particular, the present invention relates to an oil composition that is in powder form at room temperature. One embodiment of the present invention is a solid oil powder that has a very high oil content.
US08609117B2 Compositions comprising jasmonic acid derivatives and use of the derivatives
Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: wherein: R1 is a radical chosen from —COOR′, —CONR′R″, —CH2OR′, —COR′, —CH2R′, —SO2OR′, —PO3R′R″ and —NHR′, wherein R′ and R″, which may be identical or different, are defined herein; —R2 is chosen from saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are defined herein; as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.
US08609115B2 High shear application in drug delivery
In this disclosure, methods and systems for drug delivery utilizing high shear are disclosed. In an embodiment, a method comprises (1) subjecting a therapeutic fluid containing a drug to high shear; and (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug in nano-size. In an embodiment, a method comprises (1) subjecting a drug carrier and a therapeutic fluid containing a drug to high shear; and (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug carrier loaded with the drug. In an embodiment, a method comprises (1) applying high shear to a drug carrier and a therapeutic fluid containing a drug; (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug-loaded carrier; and (3) modifying the drug-loaded carrier with a targeting moiety to obtain a modified drug-loaded carrier.
US08609114B2 Methods of using a vaccine composition containing synthetic adjuvant
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.
US08609106B2 Combinations of pneumococcal RrgB clades
Pneumococcal pilus subunit RrgB has at least three clades. Serum raised against a given clade is active against pneumococci which express that RrgB clade, but is not active against strains which express one of the other two clades i.e. there is intra-clade cross-protection, but not inter-clade cross-protection. Thus an immunogenic composition can include at least two different clades of RrgB to improve strain coverage against pilus-containing pneumococci. These multiple clades may be present in the immunogenic composition as separate polypeptides or may be fused as a single polypeptide chain.
US08609105B2 Auristatin drug linker conjugates
Drug Linker compounds and Drug Linker Ligand conjugates are provided that have auristatins linked via the C-terminus. The conjugates show efficacy without the need for a self-immolative group to release the drug.
US08609103B2 Megalin-based delivery of therapeutic compounds to the brain and other tissues
The present invention is directed to a methods and compositions for receptor mediated drug delivery, particularly across the blood-brain barrier.
US08609102B2 Antibodies or fragments thereof directed against a Staphylococcus aureus epitope of ISAA or ISAB
The invention concerns antibodies or fragments thereof that are directed against a Staphylococcus aureus epitope.
US08609101B2 Granulocyte-macrophage colony-stimulating factor (GM-CSF) neutralizing antibodies
The invention provides a GM-CSF neutralizing human monoclonal antibody, 1783J22, as well as methods of making and use thereof. The monoclonal antibody is further characterized by its ability to bind epitopes from GM-CSF proteins of multiple species.
US08609098B2 Composition for repression of hyperlipidemia and obesity through suppression of intestinal cholesterol absorption
Disclosed are a composition for inhibiting hyperlipidemia and obesity through suppression of intestinal cholesterol absorption. An IgY-type antibody derived from yolk to NPC1L1 (Niemann-Pick C1-Like1), contained, as an active ingredient, in the composition of the present invention is linked to NPC1L1 (Niemann-Pick C1-Like1) that is a cholesterol transport protein in the intestines, thus interfering with binding between cholesterol and the transport protein to completely block absorption of cholesterol in the body and thereby prevent hyperlipidemia and obesity.
US08609097B2 Use of an anti-Tau pS422 antibody for the treatment of brain diseases
An antibody binding to Tau that is phosphorylated at serine 422 (pS422), which specifically binds to phosphorylated Tau fragment of SEQ ID NO:9 and to Tau pS422, but does not bind to Tau and to phosphorylated MCAK fragment of SEQ ID NO:17. The antibody is useful in the treatment of a Tauopathy.
US08609094B2 Endoglin antibodies
The present application relates to compositions of humanized and humanized/deimmunized anti-endoglin antibodies and antigen-binding fragments thereof. One aspect relates to antibodies having one or more modifications in at least one amino acid residue of at least one of the framework regions of the variable heavy chain, the variable light chain or both. Another aspect relates to antibodies which bind endoglin and inhibit angiogenesis. Another aspect relates to the deimmunization of humanized antibodies to reduce immunogenicity. Another aspect relates to the use of humanized and humanized/deimmunized antibodies which bind endoglin for the detection, diagnosis or treatment of a disease or condition associated with endoglin, angiogenesis or a combination thereof.
US08609090B2 Specific binding agents to hepatocyte growth factor
Specific binding agents that interact with hepatocyte growth factor (HGF) are described. Methods of treating cancer by administering a pharmaceutically effective amount of a specific binding agent to HGF are described. Methods of detecting the amount of HGF in a sample using a specific binding agent to HGF are described.
US08609088B2 Intranasal delivery of therapeutic enzymes to the central nervous system for the treatment of lysosomal storage diseases
The invention provides a method to prevent, inhibit or treat one or more neurological symptoms associated with a lysosomal storage disease in a mammal in need thereof, which includes intranasally administering to the mammal a composition comprising an effective amount of a lysosomal storage enzyme or a recombinant adeno-associated virus vector comprising an open reading frame encoding a lysosomal storage enzyme. Also provided are compositions and devices useful in the methods.
US08609072B2 Topical skin care formulations comprising plant extracts
Disclosed are compositions and corresponding methods of their use that include a topical skin composition comprising an extract from Boehmeria platyphylla, an extract from Karelinia caspica, and an extract from Inula helianthus-aquatica.
US08609068B2 Continuous silica production process and silica product prepared from same
Disclosed herein is a continuous process for preparing a silica product, comprising: (a) continuously feeding an acidulating agent and an alkali metal silicate into a loop reaction zone comprising a stream of liquid medium; wherein at least a portion of the acidulating agent and the alkali metal silicate react to form a silica product in the liquid medium of the loop reaction zone; (b) continuously recirculating the liquid medium through the loop reaction zone; and (c) continuously discharging from the loop reaction zone a portion of the liquid medium comprising the silica product. Silica products and dentifrice compositions comprising the silica products are also disclosed. A continuous loop reactor is also disclosed.
US08609066B2 Use of UTP for the diagnosis of stenoses and other conditions of restricted blood flow
The present invention relates to methods for determining whether blood flow is restricted in a blood vessel of an individual suspected of compromised blood flow in the vessel, the method comprising the steps of delivering UTP, a derivative thereof, or a salt thereof to the vessel, assessing blood flow quantitatively in the vessel by obtaining a value that correlates to blood flow in said vessel, comparing the obtained value with a reference value, and determining whether the individual has compromised blood flow based on the results of the comparison. The invention also provides for methods of diagnosing atherosclerotic and ischemic heart diseases using UTP, a derivative thereof, or a salt thereof, as well as methods for inducing maximal hyperemia for diagnostic purposes.
US08609062B2 Specialty materials processing techniques for enhanced resonant frequency hexaferrite materials for antenna applications and other electronic devices
Processing techniques for forming a textured hexagonal ferrite materials such as Z-phase barium cobalt ferrite Ba3Co2Fe24O41 (Co2Z) to enhance the resonant frequency and other magnetic properties of the material for high frequency applications are provided. The processing techniques include magnetic texturing by using fine grain particles and sintering the material at a lower temperature than conventional firing temperatures to inhibit reduction of iron. The processing techniques also may include aligning M-phase (BaFe12O19 uniaxial magnetization) with non-magnetic additives in a static magnetic field and reacting with BaO source and CoO to form Z-phase (Ba3Me2Fe24O42). In some implementations, processing techniques includes aligning Co2Z phase (planar magnetization) with magnetic texturing occurring in a rotating magnetic field.
US08609059B2 Production method, production vessel and member for nitride crystal
To provide a production method for a nitride crystal, where a nitride crystal can be prevented from precipitating in a portion other than on a seed crystal and the production efficiency of a gallium nitride single crystal grown on the seed crystal can be enhanced. In a method for producing a nitride crystal by an ammonothermal method in a vessel containing a mineralizer-containing solution, out of the surfaces of said vessel and a member provided in said vessel, at least a part of the portion coming into contact with said solution is constituted by a metal or alloy containing one or more atoms selected from the group consisting of tantalum (Ta), tungsten (W) and titanium (Ti), and has a surface roughness (Ra) of less than 1.80 μm.
US08609052B2 Hybrid reactor with two reaction zones
The invention relates to a hybrid reverse flow catalytic apparatus having two reaction zones: a homogeneous reaction zone in porous ceramic and a heterogeneous reaction zone with catalyst, arranged in two different catalyst beds. A first catalytic bed located in a central region of the reactor is provided with a low activity catalyst and a second catalyst bed located in a peripheral region of the reactor is provided with a high activity catalyst. The provision of two catalyst beds containing different catalysts reduces the effect of radial temperature gradients in the reactor and improves the overall efficiency of the reactor. The invention also relates to method of performing catalytic and thermochemical reactions in said apparatus.
US08609047B2 Extruded SCR filter
A wall-flow filter comprises a catalyst for converting oxides of nitrogen in the presence of a reducing agent, which wall-flow filter comprising an extruded solid body comprising: 10-95% by weight of at least one binder/matrix component; 5-90% by weight of a zeolitic molecular sieve, a non-zeolitic molecular sieve or a mixture of any two or more thereof; and 0-80% by weight optionally stabilized ceria, which catalyst comprising at least one metal, wherein: the at least one metal is present throughout the extruded solid body alone or in combination with: is also present in a higher concentration at a surface of the extruded solid body; is also carried in one or more coating layer(s) on a surface of the extruded solid body; or both.
US08609044B2 Vessel for performing microwave-assisted chemistry on small volumes of reagents
A micro vial assembly for performing microwave-assisted chemical reactions on small reaction mixture volumes is disclosed, wherein a reaction vessel (10) is sealed through a diaphragm (30) that is capped over an open end of the reaction vessel. The reaction vessel mouths in an end plane of a sleeve (20) surrounding the reaction vessel, the diaphragm being clamped for sealing the open end of the vessel by means of a cap (40) which is secured to the sleeve. The sleeve provides a radial extension of the reaction vessel in order to bridge the radial distance between a wall of the reaction vessel and other components in a system for performing microwave-assisted chemical reactions.
US08609043B2 Use of a container of an inorganic additive containing plastic material
The present invention relates to the use of a container, made of an inorganic additive containing plastic material, for reducing physical/chemical interaction between the container and an oil, fat and/or wax containing formulation contained therein.
US08609042B2 Method of cutting at least one thin section and tagging at least one specimen slide
A method of cutting at least one thin section from a sample block that is arranged in a cassette and tagging at least one specimen slide such that it can be allocated to the specific sample block from which the thin section has been cut. The method includes removing a cassette from a cassette magazine; reading the machine-readable coded information of the cassette identifier; generating by at least one tagging unit a specimen slide identifier that interrelates to the cassette identifier read by the reading unit; inserting the cassette into a microtome; transferring data from the microtome to a tagging unit via a data transfer path while the cassette is inserted into the microtome; enabling tagging of the specimen slide; tagging the specimen slide by the tagging unit; and cutting the thin section and transferring it onto the specimen slide that was tagged by the tagging unit.
US08609040B2 System for creation of formulations and generation of denaturation graphs
A system for automatically creating a denaturation curve is disclosed. In accordance with certain embodiments, a movement system including a unit having a plurality of cannulas is used. The cannulas are in fluid communication with a fluid system, which allows the cannulas to draw in and dispense fluid. A measurement system is included which draws fluid from a well into a detector to determine a characteristic of the fluid. A controller is used to control these systems and also to create a denaturation graph from the measured characteristics. In another embodiment, a plurality of formulations may be created using the system.
US08609033B2 Syringe, system and method for delivering oxygen-ozone
In accordance with at least one exemplary embodiment, a syringe, method and system for delivering a therapeutic amount of ozone are disclosed. An exemplary syringe can have a gas chamber and one or more electrodes. A portion of at least one electrode can be within the gas chamber. Alternatively, singularly or in conjunction, one or both electrodes can be attached to the outside of an exemplary syringe. One or more electrical contact points can be outside the gas chamber. Each electrical contact point can be connected to an electrode. Oxygen gas can provided within the gas chamber of the exemplary syringe. A medical ozone generator can be connected to the syringe via the electrical contact points. Corona discharge can be effectuated via the electrodes, which can result in an amount of ozone gas can being produced from the oxygen gas.
US08609021B2 Method for disinfecting a room and objects contained therein and disinfecting composition
The present invention relates to a method for disinfecting a room and the objects that may be contained therein, or surfaces in general, including the following steps: (a) determining the volume of the room to be disinfected; (b) as a function of the value determined in step a) above, determining a volumetric concentration of an aqueous disinfecting solution delivered into the room in the form of a dry mist required for obtaining a predefined level of disinfection, said disinfecting solution comprising hydrogen peroxide and silver ions (Ag+); (c) delivering into the room said aqueous disinfecting solution in the form of a dry mist until the desired volumetric concentration is achieved; (d) keeping said aqueous disinfecting solution in the form of a dry mist in contact with the room and with the objects that may be contained therein for a predefined time, so as to achieve a desired level of disinfection. A second object of the present invention consists in a disinfecting solution that is particularly suitable for implementing said method.
US08609019B2 Material composition for producing a fireproof material and the use thereof, and fireproof molded body and method for the production thereof
A method for producing a refractory molded boy using a material composition having a fine-grain fraction with grain sizes of less than 100 μm and a coarse-grain fraction with grain sizes of more than 100 μm. The method includes the steps of adding a dispersing agent and/or a liquefier to the material composition unless the material compositing already includes the dispersing agent and/or liquefier, forming the material composition into a molded body, and sintering the molded body at a temperature above 1300 degrees Celsius.
US08609015B2 Method for forming resin molded articles, apparatus for forming resin molded articles, and apparatus for adjusting thickness of thermoplastic resin sheet
There is provided a method for forming a resin molded article characterized by comprising the steps of melting and kneading a thermoplastic resin, storing a predetermined amount of the melted and kneaded thermoplastic resin, extruding the stored thermoplastic resin intermittently in a predetermined extrusion amount per unit time from an extrusion slit provided in a T-die and having a predetermined gap and sandwiching the sheet-shaped resin between a pair of rollers arranged below the extrusion slit and feeding the resin downward at a feeding speed higher than, or equal to the predetermined extrusion speed by rotary driving of the rollers, disposing the sheet-shaped molten resin, fed by the rollers, near a side of a mold arranged below the pair of rollers, and forming the sheet-shaped resin in a shape conforming to a shape of the mold.
US08609008B2 Mold, imprint method, and method of manufacturing article
A surface of a mold for an imprint apparatus on a side of a substrate includes a central region having the pattern, and a pair of first peripheral regions. The central region includes a pair of boundaries parallel to a first direction. The pair of first peripheral regions are located outside the pair of boundaries parallel to the first direction. The pair of first peripheral regions include first regions in which mold-side marks are formed and second regions in which no mold-side marks are formed. A gap between the first regions and the substrate is not filled with a resin upon an imprint process. A gap between the second regions and the substrate is filled with the resin upon an imprint process. The first regions and the second regions are opposed to each other on opposite sides of the central region.
US08609003B2 Apparatus and method for forming an antibiotic impregnated bone cement intramedullary nail
A method and apparatus for forming any size antibiotic impregnated bone cement (AIBC) intramedullary (IM) nail. The cement nail is formed around a base support or base IM nail. The apparatus includes a molded plastic tube device to form the shape of the cement IM nail and plastic spacers which position the molded plastic tube around the base support or base IM nail for formation of the cement nail. The AIBC material may be any of the known antibiotic loaded/impregnated bone cements that are commercially available.
US08609002B2 Method of plugging a honeycomb body
An apparatus for plugging honeycomb bodies includes a controller configured to signal a plugging actuator to move a plugging piston from the predetermined start position to an extended position while a shutter plate is in an open orientation, wherein at least about 50% of the predetermined volume of plugging material is discharged from a dispensing area during a single plugging cycle. The controller is still further configured to signal a control actuator of a plugging material control module to adjust a position of a control piston within a control chamber to maintain a pressure of the plugging material within the dispensing area from between greater than 0 psi to about 200 psi when the shutter plate is moved between a closed orientation and the open orientation at the beginning of the plugging cycle. Further examples include methods of plugging a honeycomb body with a plugging material control module.
US08609000B2 Method for manufacturing a housing of a numeric display
The method for manufacturing a housing of a numeric display have the steps of: providing a first injection-molding step for forming a reflecting cover, wherein the reflecting cover has a plurality of pattern segment units, each pattern segment unit is defined by reflecting surfaces of the reflecting cover and has a through hole, and providing a second injection-molding step for forming a transparent injection-molded body into each pattern segment unit, surfaces of the formed transparent injection-molded body being bonded to the corresponding reflecting surfaces, and the reflecting cover and the transparent injection-molded body being constructed as the housing of the numeric display.
US08608995B2 Method for manufacturing a separated tip catheter
A method for manufacturing a separated tip catheter having a separated tip configuration includes the steps of: extruding an extrusion material through a die to form a catheter including a catheter body having a proximal end and a distal end and defining a first lumen and a second lumen, the catheter body having a septum positioned between the first and second lumens; and feeding a strip into the die so that the strip is positioned between the first lumen and the second lumen along a length of the catheter, the strip having a first proximal section formed of a first material capable of bonding with the extrusion material and a second distal section formed of a second material incapable of bonding with the extrusion material.
US08608994B2 Silicon-based green bodies
The present invention relates to a sol-gel process for the inexpensively and in large quantities agglomeration of silicon particles in a green body which is more suitable for industrial uses of silicon than the powder itself.
US08608993B2 Mechanically strong, thermally stable, and electrically conductive nanocomposite structure and method of fabricating same
A nanocomposite structure and method of fabricating same are provided. The nanocomposite structure is a polymer in an extruded shape with carbon nanotubes (CNTs) longitudinally disposed and dispersed in the extruded shape along a dimension thereof. The polymer is characteristically defined as having a viscosity of at least approximately 100,000 poise at a temperature of 200° C.
US08608992B2 Carbon nanofibers derived from polymer nanofibers and method of producing the nanofibers
A method for producing one or more nanofibers includes providing (a) a solution comprising a polymer and a solvent, (b) a nozzle for ejecting the solution, and (c) a stationary collector disposed a distance d apart from the nozzle. A voltage is applied between the nozzle and the stationary collector, and a jet of the solution is ejected from the nozzle toward the stationary collector. An electric field intensity of between about 0.5 and about 2.0 kV/cm is maintained, where the electric field intensity is defined as a ratio of the voltage to the distance d. At least a portion of the solvent from the stream is evaporated, and one or more polymer nanofibers are deposited on the stationary collector as the stream impinges thereupon. Each polymer nanofiber has an average diameter of about 500 nm or less and may serve as a precursor for carbon fiber production.
US08608990B1 Fire retardant materials and methods
Fire retardant materials are provided that contain carbon nanotubes and particles capable of endothermically reacting when exposed to elevated temperatures. The carbon nanotubes may be a buckypaper. Methods also are provided for making a fire retardant material and for improving the fire retardation capabilities of a material.
US08608983B2 Composite anode active material, anode including the composite anode active material, lithium battery including the anode, and method of preparing the composite anode active material
A composite anode active material including metal core particles and carbon nanotubes that are covalently bound to the metal core particles, an anode including the composite anode active material, a lithium battery employing the anode, and a method of preparing the composite anode active material.
US08608980B2 Phosphor, method for producing the same and light-emitting device using the same
A method for providing a phosphor, including a kneading step in which a raw material is kneaded to provide a raw material mixture; a sintering step in which the raw material mixture is sintered; and a heat treatment step in which the sintered raw material mixture is heat-treated, wherein the raw material includes at least one or more M-containing materials selected from MSi2, MSiN2, M2Si5N8, M3Al2N4 and MSi6N8, wherein M is one or more divalent elements selected from M(0) and M(1).
US08608977B2 Polymerizable chiral compounds comprising 2,6-naphthyl and isomannitol units, and use thereof as chiral dopants
The present invention relates to compounds of the general formula I in which the variables are each defined as follows: W is a (Y4-T2-)s(Y3-A2-)tY2—Z2 moiety, Z1, Z2 are each independently unreactive radicals as defined more specifically in the description or reactive radicals through which polymerization can be brought about, A1, A2 are each independently spacers as defined more specifically in the description, Y1 to Y5 are linking units as defined more specifically in the description, Y6 is a chemical single bond or —CO—, T1, T2 are each independently, as defined more specifically in the description, divalent saturated or unsaturated, optionally substituted and optionally fused iso- or heterocyclic radicals, Q is substituents as defined more specifically in the description, r, t are each independently 0 or 1, s is 0, 1, 2 or 3 and q is 0, 1, 2, 3 or 4. The invention further relates to a liquid-crystalline composition which comprises at least one compound of the formula I, and to the use of the compounds of the formula I as chiral dopants.
US08608973B1 Layer-layer etch of non volatile materials using plasma
A method for etching a metal layer, comprising plurality of cycles is provided. In each cycle, an etch gas comprising PF3, CO and NO, or COF2 is flowed into a process chamber. In each cycle, the etch gas is formed into a plasma. In each cycle, the flow of the etch gas is stopped.
US08608968B2 Compositions for bioremediation and methods for using
Described herein are compounds, compositions, and methods useful for bioremediation of a contamination. In particular, described herein are compositions that include one or methyl esters of a fatty acid and one or more bioremediation reagents, and methods for their use.
US08608967B2 Multiple stationary phase matrix and uses thereof
The present invention generally provides a separation matrix comprising at least two stationary phases and a stationary phase comprising at least one chiral modality and at least one achiral modality. Also provided are methods of using the separation matrix or the stationary phase to separate enantiomers of one or more chiral molecules.
US08608964B2 Spiral reverse osmosis membrane element, method of manufacturing the same, and its use method
A spiral reverse osmosis membrane element that improves impregnation property of a sealing resin at edges of a membrane leaf and can effectively prevent micro-leaks. The spiral reverse osmosis membrane element comprises a cylindrically wound body comprising a perforated core tube and, spirally wound therearound, a separation membrane, a feed-side passage material and a permeation-side passage material in a laminated state, and a sealing portion for preventing a feed-side liquid and a permeation-side liquid from being mixed together, wherein the separation membrane facing the permeation-side passage material has a structure that a porous support and a skin layer are successively laminated on a non-woven fabric layer, and the sealing portion sealed with a sealing resin is provided at the edges of the separation membrane, wherein the separation membrane is impregnated with the sealing resin at least up to the vicinity of the skin layer through the porous support.
US08608955B2 Automatic slurry strainer
An automatic strainer assembly for straining a slurry comprises an inlet for receiving the slurry, a horizontally disposed strainer body in fluid communication with the inlet, and a rotatable strainer member received within the body having an inner surface and an outer surface. One or more scrapers are positioned for removing material from the outer surface of the strainer assembly. A collection vessel is positioned substantially below the body for receiving material scraped from the outer surface of the strainer member. A transport member can be provided for returning the scraped material to the slurry supply for reprocessing thereof. An outlet expels the strained slurry. A manual or automatic washdown system is provided for removing the slurry from the strainer member. A radial bearing assembly and radial seal are associated with the drive shaft of the strainer member to prevent galling. A method for processing a slurry is provided.
US08608953B2 Metabolic detoxification system and method
An extracorporeal filtration and detoxification system and method generally comprise separating ultrafiltrate from cellular components of blood, treating the ultrafiltrate independently of the cellular components in a recirculation circuit, recombining treated ultrafiltrate and the cellular components, and returning whole blood to the patient. A recirculation circuit generally comprises an active cartridge including active cells operative to effectuate a selected treatment; in some embodiments, the active cells are the C3A cell line.
US08608950B2 Process for removing metals from resid
A process for removing a metal from a resid feed includes contacting the resid feed comprising the metal with a resid-immiscible ionic liquid to produce a resid and resid-immiscible ionic liquid mixture, and separating the mixture to produce a resid effluent having a reduced metal content relative to the resid feed.
US08608949B2 Process for removing metals from vacuum gas oil
A process for removing a metal from a vacuum gas oil feed includes contacting the vacuum gas oil feed comprising the metal with a VGO-immiscible ionic liquid to produce a vacuum gas oil and VGO-immiscible ionic liquid mixture, and separating the mixture to produce a vacuum gas oil effluent having a reduced metal content relative to the vacuum gas oil feed.
US08608948B2 Method of making an oil and polar additive impregnated composition useful in the catalytic hydroprocessing of hydrocarbons
A composition that comprises a support material having incorporated therein a metal component and impregnated with both hydrocarbon oil and a polar additive. The composition that is impregnated with both hydrocarbon oil and polar additive is useful in the hydrotreating of hydrocarbon feedstocks, and it is especially useful in applications involving delayed feed introduction whereby the composition is first treated with hot hydrogen, and, optionally, with a sulfur compound, prior to contacting it with a hydrocarbon feedstock under hydrodesulfurization process conditions.
US08608947B2 Two-stage hydrotreating process
A process is provided to produce an ultra low sulfur diesel using a two stage hydrotreating reaction zone. The first stage hydrotreater may operate with a continuous liquid phase.
US08608941B2 Reforming process with integrated fluid catalytic cracker gasoline and hydroprocessed cycle oil
A reforming process includes integrating catalytic cracking product naphtha dehydrogenation and naphtha from a hydrocracking zone and feeding them to a dehydrogenation zone. The dehydrogenation zone includes a first portion of reforming catalyst from a catalyst regenerator that moves downward through the dehydrogenation zone. A product stream from the dehydrogenation zone flows to an aromatics unit and is separated into an aromatic-rich extract and a raffinate. Straight run naphtha and the raffinate are introduced to a first reforming zone that includes a second portion of reforming catalyst. The reforming catalyst moves through the first reforming zone then is removed from the bottom of each of the first reforming zone and the dehydrogenation zone and is fed to a second reforming zone. An effluent from the first reforming zone is fed to a plurality of reforming zones. The reforming catalyst moves downward through the multiple reforming zones then to a regenerator.
US08608939B2 Process for removing asphaltenic particles
Process for removing asphaltenic particles from a hydrocarbon feed containing asphaltenic particles by treating the feed in a filter unit comprising a perforated tube surrounded by hollow longitudinal projections comprising a filter having openings of at most 50 micrometer diameter in which the internal space of each of the hollow projections is in fluid communication with the inside of the perforated tube and which filter is regularly subjected to cleaning by treating each of the projections with cleaning fluid wherein the flow of cleaning fluid is opposite to the direction of normal flow.
US08608936B2 Device and method for production of hydrogen
A device for producing hydrogen in an electric field includes a shaft rotationally coupled via bearings to a vacuum protection housing, which encloses a disc like structure fastened to the shaft that supplies a split medium provided through inlet channels situated at one longitudinal end of the shaft to split cells arranged at a periphery of the disc like structure. Each split cell includes first and second electrodes. To the vacuum protection housing are fastened diffusor-spirals where a produced gas and a material residue from the split cells are provided through a plurality of nozzles, each of which is arranged inside one of the diffusor-spirals with minimal clearance between an outer wall of the nozzle and an inner wall of the associated diffusor-spiral. A rotation of the disk like structure is supported by a gas pressure generated by the produced gas emitted from the nozzles.
US08608934B2 Nickel-zinc-aluminum-hydrogen production reactor and methods of use
The technology provides apparatus and methods for generating hydrogen without applying electrical energy from an outside source. An exemplary apparatus has an outer housing having an interior divided into an upper portion and a lower portion separated by a septum. The lower portion contains an electrolyte and a composite electrode at least partially immersed in the electrolyte. The electrolyte includes zinc hydroxide dissolved therein. The composite electrode has an aluminum tube enclosing at least one magnet. An outer surface of the electrode housing is at least partially covered with nano-particles held in place by magnetic attraction of the at least one magnet to form the electrode. The magnetically-adherent nano-particles form a second electrode, in direct contact with the first electrode. The generator apparatus has a vent in communication with the upper portion of the interior of the outer housing for removal of generated hydrogen.
US08608932B2 Cyanide-free silver electroplating solutions
A cyanide-free silver electroplating solution may be used to electroplate mirror bright silver layers at high current density ranges and at high temperatures such as in reel-to-reel electroplating. The cyanide-free silver electroplating solution is environmentally friendly.
US08608927B2 Ion sensor
Provided is an ion sensor with which the concentration of ions in a solution can be determined without any reference electrode. The ion sensor is equipped with: a first electrode plate; a second electrode plate which has been disposed opposite the first electrode plate and has one or multiple openings; an ion-sensitive film continuously formed so that the film is interposed between the first electrode plate and the second electrode plate, blocks up one side of each opening of the second electrode plate, and extends from the end of that side of the opening to the outer surface of the second electrode plate through the inner wall surface of the opening; and a sensor support which supports the second electrode plate so that when the ion concentration of a test solution to be examined is determined, the ion-sensitive film comes into contact with the test solution only in the portions thereof that have been formed in each opening and on the outer surface of the second electrode plate. The ion sensor is configured so that the thickness of the ion-sensitive film interposed between the first electrode plate and the second electrode plate is different from the thickness of the ion-sensitive film formed on the outer surface of the second electrode plate. A difference in potential between the first electrode plate and the second electrode plate is measured.
US08608925B2 Multiple-electrode ionic probe
A multiple-electrode ion meter (100) is provided. The multiple-electrode ion meter (100) includes meter electronics (102) configured to receive a plurality of ionic concentration voltage measurements and generate an ionic concentration measurement from the plurality of ionic concentration voltage measurements and three or more individual electrode units (108) in communication with the meter electronics (102). The three or more electrode units (108) generate the plurality of ionic concentration voltage measurements to the meter electronics (102).
US08608922B2 Biosensor for continuous monitoring of metabolites and proteins and methods of manufacture thereof
A biosensor comprises a substrate; a reference electrode; a working electrode; a counter electrode; and a plurality of permeability adjusting spacers. The reference electrode, the working electrode and the plurality of permeability adjusting spacers are all being disposed to be substantially parallel to each other to create a plurality of enzyme containing porous sections. The enzyme containing porous sections contain an enzyme; where the enzyme is operative to react with a metabolite to determine the concentration of the metabolite. By combining a number of the aforementioned biosensors, the differential concentration of a target enzyme or protein is determined by monitoring the changes on its metabolite substrates.
US08608919B2 Impedimetric sensor and applications thereof
A highly sensitive impedimetric sensor in which the highly conductive electrodes are separated by a barrier of insulating material is disclosed. The sensor is used to determine directly the presence of analytes in a biological sample of human, veterinary or environmental origin.
US08608917B2 Reference electrode
A reference electrode for improving a product life cycle without using a gelled hydrophobic ionic liquid having a prescribed hardness or viscosity and without having a large thickness so as to be difficult to manufacture is provided. The reference electrode is provided with a housing for accommodating an internal electrode, a filler for electrically connecting the internal electrode, and a sample liquid. The filler is formed having a layer between the internal electrode and an opening formed in the housing for contacting the sample liquid and the filler. The filler includes a first layer including a water soluble electrolytic solution formed to be in contact with the internal electrode a second layer including a hydrophobic ionic liquid formed to be in contact with the first layer; and a third layer including a gelled hydrophobic ionic liquid formed in the opening so as to be in contact with the second layer.
US08608915B2 Electrolytic cell and method of use thereof
In one embodiment of the present invention an electrolytic cell is provided comprising a containment vessel; a first electrode; a second electrode; a source of electrical current in electrical communication with the first electrode and the second electrode; an electrolyte in fluid communication with the first electrode and the second electrode; a gas, wherein the gas is formed during electrolysis at or near the first electrode; and a separator; wherein the separator includes an inclined surface to direct flow of the electrolyte and the gas due to a difference between density of the electrolyte and the combined density of the electrolyte and the gas such that the gas substantially flows in a direction distal to the second electrode.
US08608914B2 Electrolysis system and method
A molten salt electrolysis apparatus and a molten metal electrolyzing method using such a device are disclosed having an electrolysis vessel (4) accommodating melt electrolyte including melt metal chloride, and an electrode unit (1) having electrically conductive electrodes (8), first insulation members (9) covering upper end surfaces of the electrodes and fixed thereto while extending upward from the upper end surfaces, second insulation members (10) covering lower end surfaces of the electrodes and fixed thereto while extending downward from the lower end surfaces, and an electrode frame (12) composed of an insulating body surrounding the electrodes, the electrode unit being immersed in the melt electrolyte.
US08608906B2 Cellulose-reinforced high mineral content products and methods of making the same
A method to prepare aqueous furnishes useful as feedstock in the manufacture of very high-mineral content products, particularly paper sheets having mineral filler content up to 90% that display the required physical properties for the intended applications; the furnishes comprise fibrillated long fibers/mineral fillers mixed with anionic acrylic binders and co-additives, in presence or absence of cellulose fibrils; the fibrillated long fibers and cellulose fibrils provide high surface area for greater filler fixation and the reinforcement backbone network that ties all of the product components together; the anionic binders allow rapid and strong fixation of filler particles onto the surfaces of fibrils when mixing is conducted at temperatures higher than the glass transition temperature (Tg) of the binder. The aqueous furnish provides excellent filler retention and drainage during product fabrication.
US08608905B2 Method for producing fiber product
This invention concerns the production of a multilayer fiber product. According to the method, on top of a bottom layer consisting of at least one fiber layer, a second fiber layer is fitted containing filler that forms the surface layer. According to the invention, the layers are formed by multilayer web forming technology, and the surface layer filler includes cellulose or lignocellulose fibrils, on which light-scattering material particles are deposited, having a maximum proportion of the total filler weight of 85%. By means of the invention, a base paper is achieved that is suited to thin, coated paper grades, where conventionally the intrusion of the coating color into the bottom paper and through it is a problem.
US08608904B1 Creping adhesive modifier and methods for producing paper products
A creping aid system for use on a creping cylinder, for example, a Yankee dryer, comprises a creping adhesive and a creping modifier, the combination comprising polyethylene.
US08608901B2 Process chamber cleaning method in substrate processing apparatus, substrate processing apparatus, and substrate processing method
In a substrate processing apparatus configured to perform a predetermined process on a target substrate accommodated in a process chamber, the process chamber is cleaned by alternately performing an operation of generating plasma of a gas containing oxygen within the process chamber, and an operation of generating plasma of a gas containing nitrogen within the process chamber.
US08608899B2 Heat-curing epoxy resin composition comprising an accelerator having heteroatoms
A heat-curing epoxy resin composition that includes an epoxy resin, a curing agent, an accelerator, and an optional toughener. The epoxy resin compositions are suitable in particular for use as bodyshell adhesives and for preparation of structural foams. An accelerator of formula (I) results in increased impact strength the of heat-curing epoxy resin compositions.
US08608897B2 Method of applying adhesive coated film
An adhesive-applying method is disclosed herein. The method comprises: providing a film comprising pressure sensitive adhesive coated on a major surface thereof; heating the film to a softening point of the film; and pressing the film against a substrate with an application device, the application device comprising a film-contacting portion, the film-contacting portion comprising a foam material and having a thermal conductivity of less than 1.8 BTU/hr-in-ft2-° F.; wherein the pressure sensitive adhesive on the major surface of the film adheres to the substrate. Application devices and kits that may be used in conjunction with the method are also disclosed herein.
US08608894B2 Wafer level packaged focal plane array
A method for manufacturing a wafer level packaged focal plane array, in accordance with certain embodiments, includes forming a detector wafer, which may include forming detector arrays and read-out circuits. The method may also include forming a lid wafer. Forming the lid wafer may include polishing a surface of a magnetically confined Czochralski (MCZ) wafer, bonding a Czochralski wafer to the MCZ wafer, and forming pockets in the Czochralski wafer. Each pocked may expose a portion of the polished surface of the MCZ wafer. The method may further include bonding the lid wafer and the detector wafer together such that the each detector array and read-out circuit are sealed within a different pocket, thereby forming a plurality of wafer level packaged focal plane arrays. The method may additionally include separating at least one wafer level packaged focal plan array from the plurality of wafer level packaged focal plane arrays.
US08608893B2 Blue-light cured adhesives for joining fabric
A system is provided for joining fabrics by lines or arrays of dots of adhesive, the system comprising: a blue light source; a dispenser, disposed proximally with the blue light source, the dispensing system being configured to deposit at least one drop of a monomer on first and second proximate fabric surfaces; a conveyance whereby the light source and the dispensing system change position relative to the first and second fabric surfaces.
US08608891B2 Method for manufacturing a microfluidic sensor
A method to manufacture microfluidic sensors 100, 100′, 132, 280, 380, includes stacking a plurality of layers of material to form at least a first cap layer 102, a first channel layer 104, an interrogation layer 106, and a second channel layer 108. During assembly, ribbon sections of substrate layers are sandwiched to cooperatively align elements through-the-thickness of the sandwich. Individual sensors are then removed from the sandwich ribbon 504. A componentizing step includes forming one or more element for successive sensors spaced along the axial length of a ribbon of substrate material. Certain elements include electrically conductive patterned structures 250 printed onto a substrate using conductive ink and a printing process. Sometimes, the printing process places material in operable position to conduct electricity through the thickness of at least one ribbon. Other elements may include channels 112, 116; tunnels 114, and vias 260, 268.
US08608888B2 Method and apparatus for stretching a liner and everting the liner into a pipe
An apparatus for lining a pipe, comprising a liner having a non-everted portion and an everted portion, and a stretching device. The stretching device includes at least two stretch members secured to the everted portion on substantially opposing sides, and a force mechanism to facilitate movement of the stretch members away from each other in order to stretch the evert portion of the liner. Preferably, the liner comprises an inner layer and an outer layer, and the stretch members are positioned between the inner and outer layers. In another aspect, the present invention provides a method of everting a liner into a pipe. The method includes flipping an open end of the liner inside out to create an everted portion, engaging a sidewall of the liner at two opposing locations on the everted portion, and applying a force at the two locations to stretch the everted portion of the liner.
US08608884B2 Method and system for mounting objects to polymeric membranes
A mounting plate utilized to attach an object to a mounting system. The mounting plate includes a base having a top surface and a bottom surface. The bottom surface of the base is bonded to a membrane of the mounting system. A housing is raised from the top surface of the base, the housing creates a contact surface area to support the object. A first member is raised from the top surface; the first member has a surface at a height flush with the contact surface area of the housing. A hole extends through the thickness of the housing.
US08608882B2 Composite web, disposable diaper and process for manufacturing thereof
The present invention relates to a process for manufacturing a composite web for use in a disposable product, the process comprising the steps of: a) providing a continuous web of material; b) creating in the web a longitudinally repeating pattern of windows; and c) attaching at least one strip to the web, said strip at least partially covering the windows and having different functional characteristics than the web. The present invention also relates to a composite web formed in accordance with this process and to panels obtainable by cutting said web in cross direction.
US08608878B2 Slow burning heat generating structure
A heat generating structure includes a substrate, a coating and a polymeric material. The substrate comprises a first material. The coating comprises a second material, different from the first material that covers at least a portion of the substrate. The coating and substrate, upon being thermally energized to their minimum alloying temperature, react in a first exothermic reaction that is an alloying reaction. The relative quantities of the substrate and coating are such that the first exothermic reaction yields a first amount of exothermic energy that is insufficient to cause self-sustained propagation of the first exothermic reaction. The polymeric material covers substantially all of the substrate and coating, and is different from the first and second materials. The polymeric layer, upon being thermally energized, reacts with at least one of the substrate and coating in a second exothermic reaction. The second exothermic reaction yields a second amount of exothermic energy that, when combined with the first amount of exothermic energy, is sufficient to propagate the first exothermic reaction in a self-sustained manner.
US08608877B2 Nickel alloy and articles
Articles that include a material that has L12-structured gamma-prime phase precipitates within a matrix phase at a concentration of at least 20% by volume are disclosed. The gamma-prime phase precipitates are less than 1 micrometer in size. The material also has A3-structured eta phase precipitates distributed within the matrix phase at a concentration in the range from about 1% to about 25% by volume. The articles may be formed by mechanically working a workpiece that has at least about 40% nickel, about 1.5% to about 8% titanium, and about 1.5% to about 4.5% aluminum. The workpiece may be worked at a temperature below a solvus temperature of the eta phase; and then heat treated at a temperature sufficient to dissolve any gamma prime phase present in the workpiece but below the solvus temperature of the eta phase.
US08608873B2 Stainless steel, cold strip produced from this steel, and method for producing a flat steel product from this steel
A stainless steel and a flat cold product produced therefrom, which can be easily produced in an economical manner. A steel according to the invention, in the cold-rolled state, has a microstructure with 5-15% by volume δ-ferrite and austenite as the remainder. It contains (in % by weight):C: 0.05-0.14%, Si: 0.1-1.0%, Mn: 4.0-12.0%, Cr: >17.5-22.0%, Ni: 1.0-4.0%, Cu: 1.0-3.0%, N: 0.03-0.2%, P: max. 0.07%, S: max. 0.01%, Mo: max. 0.5%, optionally one or more elements from the group consisting of Ti, Nb, B, V, Al, Ca, As, Sn, Sb, Pb, Bi, and H wherein Ti: max. 0.02%, Nb: max. 0.1%, B: max. 0.004%, V: max. 0.1%, Al: 0.001-0.03%, Ca: 0.0005-0.003%, As: 0.003-0.015%, Sn: 0.003-0.01%, Pb: max. 0.01%, Bi: max. 0.01%, H: max. 0.0025%, and remainder Fe and unavoidable impurities.
US08608871B2 High-strength steel tube having excellent chemical conversion treatability and excellent formability and method for manufacturing the same
There is provided a high-strength steel tube having excellent chemical conversion treatability and excellent formability and a method for manufacturing the high-strength steel tube. More specifically, in processing a mother steel sheet containing, on the basis of mass percent, 0.05% or more C, more than 0.7% Si, and 0.8% or more Mn into a pipe shape, the sum total of absolute circumferential surface strains each applied in individual process steps of the processing is 5% or more as nominal strain. A welded steel tube thus manufactured using a steel sheet even containing more than 0.7% Si can have excellent chemical conversion treatability without mechanical grinding or chemical pickling treatment.
US08608869B2 Surface treatment of magnesium alloy castings for corrosion protection
A method is disclosed for improving the corrosion behavior of cast magnesium alloy articles in which the magnesium alloy comprises an average composition of more than about 5 per cent by weight of aluminum. A microstructure with regions of varying aluminum content is developed during solidification. The microstructure comprises magnesium-rich grains generally surrounded by an aluminum-enriched phase on the boundaries between adjacent grains. The magnesium-rich grain interiors are then selectively chemically or electrochemically attacked to leave a more corrosion resistant aluminum-enriched surface on the articles. The corrosion resistance of the articles may be further enhanced by one or more of anodizing, aluminizing or painting the corrosion-resistant aluminum-enriched surface.
US08608859B2 Method for removing contamination from a substrate and for making a cleaning solution
A method is provided for removing contamination from a substrate. The method includes applying a cleaning solution having a dispersed phase, a continuous phase and particles dispersed within the continuous phase to a surface of the substrate. The method includes forcing one of the particles dispersed within the continuous phase proximate to one of the surface contaminants. The forcing is sufficient to overcome any repulsive forces between the particles and the surface contaminants so that the one of the particles and the one of the surface contaminants are engaged. The method also includes removing the engaged particle and surface contaminant from the surface of the substrate. A process to manufacture the cleaning material is also provided.
US08608857B2 Rheological fluids for particle removal
Methods and apparatus for cleaning a substrate (e.g., wafer) in the fabrication of semiconductor devices utilizing electrorheological (ER) and magnetorheological (MR) fluids to remove contaminant residual particles from a surface of the substrate are provided.
US08608852B2 Temperature controlled plasma processing chamber component with zone dependent thermal efficiencies
Components and systems for controlling a process or chamber component temperature as a plasma process is executed by plasma processing apparatus. A first heat transfer fluid channel is disposed in a component subjacent to a working surface disposed within a plasma processing chamber such that a first length of the first channel subjacent to a first temperature zone of the working surface comprises a different heat transfer coefficient, h, or heat transfer area, A, than a second length of the first channel subjacent to a second temperature zone of the working surface. In embodiments, different heat transfer coefficients or heat transfer areas are provided as a function of temperature zone to make more independent the temperature control of the first and second temperature zones.
US08608844B2 Ink composition, ink set and image forming method
An ink composition, including: a water-soluble solvent A; a pigment; and water. The water-soluble solvent A contains at least a water-soluble solvent having an SP value of 27.5 or less at an amount of 90 mass % or more and a compound represented by the following Formula (1), wherein the compound represented by Formula (1) is the same as or different from the water-soluble solvent having an SP value of 27.5 or less: wherein, in Formula (1), l, m and n each independently represent an integer of 1 or more, the total of l, m and n is from 3 to 15, and AOs each independently represents an ethyleneoxy group or propyleneoxy group.
US08608843B2 Pigment preparation and ink jet printing ink
The present disclosure is directed to a pigment preparation comprising aluminum effect pigments, a solvent and at least one additive, wherein the aluminium effect pigments have a d98 value of the volume averaged particle size distribution curve of less than 15 μm, the at least one additive is a phosphorous containing additive, and the solvent has a viscosity equal to or more than 1.8 mPa's at 25° C. The disclosure is further directed to an ink jet printing ink as well the use thereof.
US08608842B2 Infrared absorbing composition, infrared absorbing ink, recorded article, image recording method, and image detecting method
An infrared absorbing composition including a compound that is represented by formula (1) and has solubility of 30 mg/mL or less in toluene at 25° C., an organic solvent having a solubility parameter of from 7.3 to 12.1, and a resin is disclosed. In formula (1), each of R1 to R16 independently represents a hydrogen atom or a substituent group, provided that at least one of R1 to R16 represents an R17—X— group or that the compound represented by formula (1) contains at least one condensed-ring structure in which any adjacent two of R1 to R16 form a ring; X represents —S—, —NH—, —NR18—, or —O—; each of R17 and R18 independently represents an aliphatic group or an aryl group; and M represents two atoms selected from the group consisting of hydrogen atoms and monovalent metal atoms, or a divalent metal atom, or a divalent substituted metal atom moiety including a trivalent or tetravalent metal atom and a substituent group.
US08608837B2 Process for producing carbon membranes
The use of solutions of ethylenically unsaturated polyesters for production of carbon membranes suitable for gas separation, and a process for producing carbon membranes suitable for gas separation, comprising the steps of a) coating a porous substrate with a solution of ethylenically unsaturated polyester, b) drying the polyester coating on the porous substrate by removing the solvent, and c) pyrolyzing the polyester coating on the porous substrate to form the carbon membrane suitable for gas separation, it being possible to conduct any of steps a) to c) or the sequence of steps a) to c) more than once.
US08608833B2 Selective absorption of gas components in co-current contacting apparatuses
Methods are disclosed for the selective absorption of gas components based on differences in their gas phase and liquid phase resistances to mass transfer. The methods advantageously utilize a gas-liquid contacting apparatus having contacting stages with co-current flow channels that can provide contacting with increased liquid phase resistance to mass transfer, for example in the spray regime such that the liquid is effectively dispersed as small droplets into the gas phase.
US08608831B2 Dryer for compressed gas, method for drying compressed gas, and compressor installation provided with a dryer
Compressed gas dryer, provided with a drying zone (3) and a regeneration zone (5), and a drum (9) rotatable in the housing (2) containing a drying agent (8) that is transferred successively through the drying zone (3) and the regeneration zone (5), whereby said regeneration zone (5) comprises a first subzone (6) having a first inlet to supply a first regeneration gas flow, and a second subzone (7) having a second inlet to supply a second regeneration gas flow of which the relative humidity is lower compared to that of the first regeneration gas flow; and that an outlet of said drying zone (3) is connected via a connection conduit (17) to the second inlet of the second subzone (7).
US08608827B2 Portable and stationary oxygen concentrator system
An oxygen generator includes a stationary unit and a portable unit. The portable unit includes a compressor, molecular sieves, controllable valves and an enriched gas storage chamber. The stationary unit includes a compressor having a greater capacity than a capacity of the portable compressor.
US08608822B2 Composite system
A multiphase composite system is made by binding hard particles, such as TiC particles, of various sizes with a mixture of titanium powder and aluminum, nickel, and titanium in a master alloy or as elemental materials to produce a composite system that has advantageous energy absorbing characteristics. The multiple phases of this composite system include an aggregate phase of hard particles bound with a matrix phase. The matrix phase has at least two phases with varying amounts of aluminum, nickel, and titanium. The matrix phase forms a bond with the hard particles and has varying degrees of hard and ductile phases. The composite system may be used alone or bonded to other materials such as bodies of titanium or ceramic in the manufacture of ballistic armor tiles.
US08608817B2 Meltblown filter medium
Filter media, as well as related assemblies, systems and methods. Filter media may contain one or more layers formed of a meltblown material.
US08608809B2 Stable oxidative colouring composition for keratin fibres
An oxidative dyeing composition comprises at least one oxidative dye precursor comprising further at least two structurally different reducing agents wherein the first is selected from inorganic reducing agents and present at a concentration of at least 0.1% by weight calculated to the total composition, and the second is an organic reducing agent and/or its salts selected from thioglycolic acid, acetylcysteine and cysteine, and their salts, wherein the composition is substantially free of ascorbic acid and/or its salts.
US08608808B2 Composition for dyeing keratin fibers, including at least one ortho-diphenol derivative, one particular metal derivative, and one alkalinizing agent
A subject-matter of the invention is a composition comprising a) at least one ortho-diphenol derivative, b) at least one specific metal derivative and c) at least one basifying agent, a method for dyeing keratinous fibers by treatment of the said fibers using the ingredients a), b) et c) and the use thereof for dyeing keratinous fibers. This hair dyeing method makes it possible to obtain better colorations which are more uniform, chromatic and lasting and which do not detrimentally affect the cosmetic properties of the keratinous fibers, starting from an extract of ortho-diphenols which are in particular natural.
US08608807B2 Ecological fabric having ultraviolet radiation protection
An ecological fabric having protection from ultraviolet radiation incorporated therein is disclosed in which the fabric is treated by a method comprising the steps of dissolving zinc acetate or other zinc salt in a liquid to form a solution containing Zn(II) ions, adding a fabric to the solution, mixing the solution and the fabric, and adding a base to the solution when the solution and the fabric are being mixed to form a suspension of zinc oxide nanoparticles in contact with the fabric. Other methods are disclosed such as modifying a fabric by carboxylation or phosphorylation of the fabric followed by binding of the UV-blocking nanoparticles to the modified fabric and modifying UV-blocking nanoparticles with a self-assembled monolayer (SAM) or polymer layer containing an active chemical group capable of binding to the fabric and depositing the UV-blocking nanoparticles on the fabric.
US08608804B2 Systems and methods for spinal fusion
A system and method for spinal fusion comprising a spinal fusion implant of non-bone construction releasably coupled to an insertion instrument dimensioned to introduce the spinal fusion implant into any of a variety of spinal target sites.
US08608798B2 Total artificial heart
A total artificial heart having a rotor with an impeller, wherein the rotor is mounted within a pump housing on a hollow shaft. The rotor is magnetically driven to produce rotary motion of the impeller for pumping blood. The motor is disposed within the pump housing such that axial translation within the housing acts as a shuttle valve to alternate flow between pulmonary and systemic circulation.
US08608795B2 Tapered loading system for implantable medical devices
Loading systems for compressing and loading an implantable medical device into a device chamber of a medical device delivery system are described. The loading systems include an elongate holding chamber within which the intraluminal medical device is disposed. A plunger has one or more attached pushers adapted to axially advance the intraluminal medical device through an intermediate portion of the holding chamber that has a tapered surface, which compresses the intraluminal medical device over a dilator of a medical device delivery system that has been introduced through the distal end of the elongate holding chamber. The elongate holding chamber can be placed within an outer storage container with an appropriate seal to for storage of the intraluminal medical device within the loading system. Methods of preparing an intraluminal medical device for implantation in a patient and kits useful in such methods are also described.
US08608789B2 Delivery system for bifurcation stents
Systems for aligning and deploying side branch stents comprise a catheter having a side branch sensor at or near a distal end thereof. Methods comprises rotating and axially transitioning the catheter until the sensor is brought into alignment with an opening to the side branch vessel.
US08608787B2 Device and method for irradiating tissue with light pulses
The invention relates to a device (1) for irradiating tissue (G) with light pulses (L), comprising a housing (2), at least one light source (3) for emitting the light pulses (L) with a wavelength (λ) of from 600 nm to 660 run, a modulator (4) and a power stage (6) for generating the light pulses (L), and with an activating element (5). For creating a device (1) which is as small, as cost-efficient and as effective as possible, by which as good a therapy success as possible is achieved in various applications, the modulator (4) is designed for generating the light pulses (L) with a pulse frequency (f) of from 1 to 10 Hz, and the power stage (6) is designed for emitting the light pulses (L) with an energy which causes breaking up of the photosensitizer in the photodynamic therapy and evokes a frequency doubling or a two-photon absorption (TPA) in the tissue (G) when treating inflammations without a sensitizer.
US08608773B2 Surgical robotic tools, data architecture, and use
Robotic surgical tools, systems, and methods for preparing for and performing robotic surgery include a memory mounted on the tool. The memory can perform a number of functions when the tool is loaded on the tool manipulator: first, the memory can provide a signal verifying that the tool is compatible with that particular robotic system. Secondly, the tool memory may identify the tool-type to the robotic system so that the robotic system can reconfigure its programming. Thirdly, the memory of the tool may indicate tool-specific information, including measured calibration offsets indicating misalignment of the tool drive system, tool life data, or the like. This information may be stored in a read only memory (ROM), or in a nonvolatile memory which can be written to only a single time. The invention further provides improved engagement structures for coupling robotic surgical tools with manipulator structures.
US08608772B2 Stretch resistant therapeutic device
A vasoocclusive coil is reinforced with a stretch resistant member to improve safety during retraction of the coil. The stretch resistant member is fixedly attached at one end to the vasoocclusive coil, and the other end of the stretch resistant member is detachably mounted to an elongated pusher member to allow for placement and release of the vasoocclusive coil within the patient's vasculature.
US08608769B2 Bladeless optical obturator
A surgical access device comprising a tissue separating obturator suitable for connection with a cannula is disclosed. The obturator includes an elongate shaft having a transparent distal tip. The elongate shaft extends along a longitudinal axis and defines a lumen. The transparent distal tip has a tapered configuration and includes an inner surface and an outer surface adapted for penetrating tissue. The lumen is sized and configured to receive an optical instrument such as a laparoscope. The surgical access device further includes a scope lock at the proximal end of the shaft portion. The lock includes a multi-fingered collet coaxial with the lumen. The inner diameter of the collet is smaller than an outer diameter of the optical instrument and the fingers of the collet provide frictional engagement with the outer diameter of the optical instrument that is inserted into the lumen of the obturator.
US08608767B2 Varicose vein dissector and removal apparatus
A varicose vein dissector and removal apparatus includes a handle having a first end and a second end, a dissector extending from the first end of the handle and a hook extending from the second end of the handle, and a blade positioned within the dissector for movement between a use position and a storage position. The apparatus is used by creating an initial incision in skin over a varicose vein to be removed, advancing the dissector into the incision and dissecting around the varicose vein to be removed, pushing the dissector against an inner surface of the skin a predetermined distance from the initial incision, exposing the blade by moving it from its storage position to its use position and creating a second incision in the skin letting the dissector protrude out of the skin, and grasping the vein with the hook and removing the vein.
US08608761B2 Thrombus removal device
A thrombus removal device includes a shaft with a distal end and a proximal end, a sheath with a distal end and a proximal end, and a helical coil attached at a proximal end to the distal end of the shaft and is disposed within the lumen of the sheath in a closed configuration. The helical coil includes a plurality of body portions with turns spaced apart longitudinally and laterally to facilitate screwing the helical coil into a thrombus and also providing an open area into which the thrombus can be captured. A distal tip of the helical coil is provided with a loop, an angle of which is about the same as the angle of at least one body portion. The helical coil assumes an open configuration when the sheath is retracted proximally from the distal tip.
US08608752B2 Trial intervertebral distraction spacers
An insertion tool for inserting an intervertebral spacer is provided. The tool includes first and second pincers. The first pincer is fixed and the second pincer is pivotably coupled to the first pincer at a pivot location in open-biased opposition to the first pincer. The tool includes a compression slide which may be selectively translated into and out of engagement with the second pincer. When the compression slide is in a predetermined engagement position with the second pincer, the first and second pincers are in a closed position for holding the intervertebral spacer. When the compression slide is out of engagement with the second pincer, the first and second pincers are in an open position for releasing the intervertebral spacer.
US08608749B2 Patient-specific acetabular guides and associated instruments
A method for preparing a joint surface of a patient for an implant, such as, for example, an acetabular implant for a hip joint. According to the method, a patient-specific guide is attached to a complementary joint surface of the patient. The patient-specific guide includes a guiding element oriented along a patient-specific alignment axis. The alignment axis is determined during a preoperative plan of the patient for implant alignment. A shaft of a guiding tool is removably coupled to the guiding element of the guide. A three-dimensional orientation device is removably attached to the shaft of the guiding tool. A position of a bubble of the orientation device is marked with a mark on an outer transparent surface of the orientation device while the guiding tool is oriented along the alignment axis. The marked orientation device can be used for aligning other instruments during the procedure.
US08608745B2 System, apparatus, and method for cutting bone during an orthopaedic surgical procedure
A bone saw tool includes a bone saw and a bone saw blade assembly. The bone saw blade assembly includes a bone saw blade and a bone saw blade guard. The bone saw blade guard is movable to an extended position to reduce the cutting effectiveness of the bone saw blade and/or the maximum cutting depth of the bone saw blade. The bone saw may be configured to activate the bone saw blade guard in response to a signal received from a computer system when the bone saw is moved outside a predetermined cutting region.
US08608743B2 Expandable implant
An implant system includes a fixation device that, in turn can include an expandable implant alone or in combination with an auxiliary implant. The expandable implant includes an expandable implant body that is made from an expandable material. The expandable material includes a polymer matrix and an expandable gas source contained within at least a portion of the polymer matrix. The implant system can further include an energy source configured to heat the polymer matrix to a temperature above its glass transition temperature, thereby causing the gas source to expand inside the polymer matrix. The fixation device can further include an insertion instrument configured to implant the fixation device into an anatomical cavity.
US08608742B2 Cable and crimp for bone surgery
A surgical cable and crimp device is provided. The cable has an enlargement (bead) affixed to one of its ends. The crimp member includes two holes. One of the holes includes a slot and a cavity. The cavity is sized to accept the bead of the cable, and the slot is sized to receive the flexible cable but not allow the bead to pass through. The other hole is a simple through hole. The cable can be inserted to loop the bone isolated from the crimp member. After the beaded end of the surgical cable is fastened to the crimp, the cable is passed through the simple through hole. The cable is then tensioned by the application thereto of a tensioning tool with the tool applied to the cable and to an abutment face of the crimp member.
US08608735B2 Catheter with arcuate end section
A medical device includes an insertion shaft, having a longitudinal axis and having a distal end adapted for insertion into a body of a patient. A resilient end section is fixed to the distal end of the insertion shaft and is formed so as to define, when unconstrained, an arc oriented obliquely relative to the axis and having a center of curvature on the axis. One or more electrodes are disposed at respective locations along the end section.
US08608731B2 Leaky-wave antennas for medical applications
A device for directing energy to a target volume of tissue includes a proximal portion including a first antenna assembly extending therethrough, and a distal portion including a second antenna assembly. The first antenna assembly includes a leaky-wave antenna assembly having an outer conductor and an inner conductor disposed within the outer conductor. The distal portion of the device is attached to the inner conductor. The outer conductor includes a plurality of radiating apertures defined in a distal portion thereof and is configured for radiating energy substantially uniformly along a longitudinal axis of the proximal portion.
US08608729B2 Implantable infusion device having filter
An implantable infusion device for delivering a fluid medication to a patient. The infusion device has an internal bacterial filter positioned between the reservoir and the pump, configured to provide a pathway for fluid to be pulled from the reservoir to the pump, regardless of the orientation of the infusion device. The configuration of the filter provides a fluid pathway from the reservoir to the pump, even in the presence of a gas bubble.
US08608723B2 Fluid transfer devices with sealing arrangement
The present invention is directed toward fluid transfer devices including a vial adapter having a top wall and a cannula with a cannula tip, and an elastic O-ring like sealing element sealingly encircling the cannula and initially disposed towards the cannula tip and spaced apart from the top wall, the sealing element being brought into initial contact with the vial stopper subsequent to the cannula tip contacting the vial stopper at a puncture site and thereafter being slidingly urged towards the top wall and continuously sealing the puncture site during snap fit mounting the vial adapter on the vial.
US08608721B2 Composite fastener products
Methods and systems including an engageable material with a lane of plastic resin extending across an interface of first and second ends of an article, wherein the plastic resin is bonded to the first and second ends such that the first and second ends are joined by the resin; and an array of fastener elements extending from one side of the plastic resin. The fastener elements include engageable heads on stems integrally formed with the lane of the plastic resin such that the two ends releasably engage the engageable material to secure the article.
US08608720B2 Absorbent article having an umbilical notch cut
A disposable absorbent article having a front end edge and a back end edge, wherein the front end edge is formed by a non-linear cut with an umbilical notch, and wherein the front end edge and the back end edge are complementary in shape.
US08608719B2 Disposable partially flexible surgical fluid container
A disposable partially flexible surgical fluid container. The apparatus includes a triangular shaped portion comprising a rigid fluid collection portion for storing fluids, a flexible sealing portion for creating a seal for catching surgical fluids, an ergonomic handle portion for grasping and holding and a horizontal bottom portion for standing the apparatus upright when placed on a flat surface. The flexible sealing portion includes a flexible, conformable material for conforming to flat, convex and concave wound surfaces and creating a seal between the flexible pouring portion and the wound surfaces to prevent leaking of collected surgical fluids (e.g., irrigation fluids, etc.) during a surgery.
US08608714B2 Vacuum instrument for slowing or arresting the flow of blood
The invention provides a surgical vacuum device including a vacuum cup sized for attachment to and manipulation of a target tissue. The device further includes a vacuum hose for applying a vacuum to the interior of the cup, and structure for applying a tensioning force to the cup once it has been placed and a vacuum applied. The vacuum device may be utilized with minimal or no trauma to the target tissue or surrounding tissues.
US08608712B2 Septum for venous access port assembly
A venous access port assembly having a housing with a discharge port, and a needle-penetrable septum. An interior reservoir is defined in the assembly, and a passageway extends from the reservoir through the discharge port. The needle access area of the septum includes a tactilely identifiable differentiation along the top surface thereof, such as a ridge, a recess, an X-shaped protrusion, a V-shaped groove, or a bipartite dome.
US08608710B2 Pen needle assembly with different gauge needle cannulas
A pen needle assembly is provided herein which includes: a hub having a body with a transverse wall; an arrangement for mounting the hub onto an injector; a first needle cannula extending distally from the transverse wall, the first needle cannula terminating at a distal end, formed for insertion into a patient, with a first lumen extending proximally from the distal end, the first needle cannula being of a first gauge; and, a second needle cannula extending proximally from the transverse wall, the second needle cannula extending from a distal end and terminating at a proximal end with a second lumen extending distally from the proximal end. The first and second lumens are in communication. Further, the second needle cannula is of a second gauge, the second gauge defining a larger external cross-section than the first gauge.
US08608708B2 Injector apparatus
An injector apparatus includes a housing (101, 102) for a cartridge or syringe, a plunger (40) for cooperating in use with the cartridge or syringe to express successive doses, a dose setting arrangement (16, 20) to select a dose volume, and a drive mechanism (22, 24) releasable to advance the plunger in respective predetermined increments of magnitude to express the successive doses. The drive mechanism includes a drive spring (22) for imparting movement directly or indirectly to the plunger (40), and the dose setting arrangement includes a dose setting element (16) moveable in a dose setting routine to define a magnitude of an increment of movement of the plunger for a given dose. The drive mechanism further includes a clutch arrangement (56) operable during the dose setting routine to inhibit forward movement of the plunger and/or to isolate the dose setting element from the force of the drive spring.
US08608707B2 Autoinjector with rotatable deshielder for axially displacing a needle shield
The invention relates to an automatic injection device including a container provided with a needle; a housing receiving a container movable relative to the housing between an initial position to an insertion position; a needle shield for receiving the needle and in which the needle is embedded prior to use of the device; and a deshielder coupled to the needle shield by a first connecting arrangement and removably assembled to the distal part of the housing by a second connecting arrangement. The first and second connecting arrangements are designed so that a rotational movement of the deshielder about the device axis of the device with respect to the housing causes an axial displacement of the needle shield in the distal direction with substantially no rotational movement of the needle shield with respect to the needle.
US08608706B2 Adhesive tape for an intravascular catheter
The present invention discloses an adhesive tape to secure an intravascular catheter to the skin of a patient at an intravascular site comprising: (a) a strip of tape having adhesive on all of one side except for portions at the ends, the strip of tape having a length of about 15 mm to about 300 mm and width of about 4 mm to about 30 mm; (b) two removable covers affixed near the ends of the adhesive side of the strip, wherein the removable covers are separated from each other by a centrally located portion of the strip of tape; and (c) a third removable cover affixed to the central portion of the adhesive side of the strip of tape. The subject invention further reveals a sterile intravascular starter kit, said kit being comprised of the adhesive tape for an intravascular catheter, a tourniquet, a gauze pad, an antiseptic skin preparation device, optionally a towel, and a clear occlusive dressing.
US08608704B2 Medical line securement device
A securement device includes a simply-structured retention mechanism that permits a portion of a catheter hub or a similar medical article to be easily anchored to a patient, without the use of tape or needles and suturing. A unitary retainer desirably includes a base defining a locator mechanism. The locator mechanism interacts with a fitting of the medical device so as to position the medical device relative to the retainer. The locator mechanism also desirably guides the medical device fitting into contact with an adhesive member mounted on an outer surface of the retainer. In one form, the locator mechanism includes one or more posts that engage mating holes defined in the medical device fitting. In other forms, the locator mechanism includes a cradle defining an arcuate channel to receive a convex surface of the medical device, or a recess shaped to matingly receive the fitting. The retainer is attached to a flexible anchor pad that includes an adhesive bottom surface, which can be attached to the patient's skin. In use, a health care provider positions the medical device fitting on the retainer in a position established and guided by the locator mechanism, and attaches the fitting to the retainer via the adhesive member.
US08608699B2 Systems and methods to address air, leaks and occlusions in an insulin pump system
A system and method for adjusting insulin infusion volume based on air in an infusion set tube includes inputting at least one location and length of an air bubble along the infusion set tube. An air bubble volume is determined in the infusion set tube. An insulin infusion volume is determined based on a desired insulin infusion. A determination is then made whether the desired insulin infusion would include the air bubble volume based on the inputted location and length of the air bubble. The air bubble volume is added to the insulin infusion volume to make an adjusted insulin infusion volume if the insulin infusion volume includes the air bubble.
US08608696B1 Rapid fluid cooling devices and methods for cooling fluids
A cooling device includes a target fluid inlet, a target fluid outlet, an inner conduit, and a chamber surrounding the inner conduit. The inner conduit communicates with the target fluid inlet and the target fluid outlet, and provides a flow path for a target fluid to be cooled. The chamber contains a first endothermic reactant and includes a reactant inlet selectively alterable from a closed state to an open state. When the reactant inlet is in the closed state, the first endothermic reactant is isolated from a second endothermic reactant and no endothermic reaction occurs. When the reactant inlet is in the open state, the reactant inlet provides a flow path for enabling the second endothermic reactant to come into contact with the first endothermic reactant in the chamber for initiating the endothermic reaction and cooling the target fluid in the inner conduit.
US08608695B2 Safety needle assembly
A safety needle assembly has a collar or ring that is rotatably mounted to a needle hub. The needle assembly may be connected to a syringe by the user grasping the needle hub in first and second embodiments, or turning of the needle sheath in other embodiments. The collar of the needle assembly may be rotated by turning the needle sheath. The needle hub may also interact with the collar by rotating the needle sheath. Mechanisms are provided at both the collar and the housing so that once the contaminated needle is covered, the needle assembly may be removed from the syringe for disposal by rotating the needle housing.
US08608689B2 Pharmaceutical-coated medical products, the production thereof and the use thereof
This present invention concerns a new combination of balloon catheters and formulations containing active substances that adhere to the surface of the balloon membrane. Furthermore the present invention concerns coating processes for the manufacture of these balloon catheters as well as their use in the treatment and prophylaxis of vascular diseases.
US08608688B2 Catheter apparatus
A catheter apparatus is provided with lumens for accommodating guidewires. The apparatus comprises an actuator controllable to move the distal ends of the lumens relative to each other. Accordingly, the separation of the guidewires can be controlled, enabling probing by the guidewires of different area of an occlusion in a blood vessel, such as a chronic total occlusion.
US08608678B2 Orthopedic technical device
The invention relates to an orthopedic technical device for the lower extremities, with at least one receptacle (12, 16) for an extremity (14, 18), a sensor (30) and an electric evaluating unit (34), which is connected with the sensor (30) for processing data of a sensor (30). According to the invention, it is proposed that the electric evaluating unit (34) be set up in order to carry out a method with the following steps: (i) switching into a learning mode, (ii) determining at least one characteristic value of the system (R, S, N, aw,threshold), (iii) storing the characteristic value of the system (R, S, N, aw,threshold), (iv) switching into an operating method and (v), in the operating mode, influencing, optimizing or selecting a control algorithm of the orthopedic device by means of the characteristic value of the system (R, S, N, aw,threshold).
US08608675B2 Apparatus for rehabilitation of patients suffering motor dysfunction
An apparatus for rehabilitation of patients with motor disorders affecting the legs and standing dysfunctions, the apparatus comprising a couple of bars moving along a closed loop representing a walking step for the patient, with each bar including a plate to affix a foot of the patient and the plate being slidably arranged in the bar, with a motor connected to the bars to move the bars along the closed loop, the apparatus also having an harness to support the patient.
US08608674B2 Pelvis interface
A pelvis interface may include a subject attachment module including a waist attachment and a back attachment. The interface may further include an arm assembly coupled to the subject attachment module, the arm assembly including a plurality of arms so coupled to one another and/or to the subject attachment module as to permit the subject attachment module at least one pelvis translation degree of freedom and at least one pelvis rotation degree of freedom. The interface may further include motors so coupled to the arm assembly as to actuate at least one pelvis translation degree of freedom and at least one pelvis rotation degree of freedom.
US08608672B2 Hierarchical switching in ultra-high density ultrasound array
A focused ultrasound system comprises a transducer having a multiplicity of transducer elements, drive circuitry that generates and outputs a plurality of drive signals, each offset by a respective phase difference, and a controller for selectively coupling the drive signals to respective transducer elements, the controller including a plurality of first tier switching modules and second tier switching modules. Each first tier module receives as an input the plurality of drive signals and outputs one of the drive signals in response to a drive signal selection signal. Each second tier module is coupled to a respective grouping of transducer elements and selectively couples a respective selected drive signal output from a first tier switching module to one or more of the transducer elements in response to a transducer element selection signal.
US08608671B2 Gait change determination device
A gait change determination device includes a main body unit, an accelerometer that detects an acceleration of the main body unit, and a control unit, and determines a change in the gait of a user that wears the main body unit on a predetermined area. The control unit specifies a trajectory of a predetermined area on which the main body unit is worn during walking based on accelerations detected by the accelerometer, calculates the temporal change amount of the specified trajectory, and determines the degree of change, which is the degree of the temporal change, based on the calculated temporal change. The degree of change in the gait can be more accurately determined.
US08608669B2 Lancet having capillary channel and sterile protection element and method for producing such a lancet
Lancets comprising a piercing element for puncturing the skin of a patient, a test region containing detection reagents for determining an analyte concentration of a body fluid sample, a capillary structure arranged in the piercing element for transporting a body fluid sample to the test region, and a sterile protection element, which encloses the tip of the piercing element. The capillary structure is blocked in a section surrounded by the sterile protection element. Also provided are methods for producing a lancet, comprising: producing a piercing element, which on the upper side has an upwardly open capillary structure; covering a section of the upper side of the piercing element and blocking the capillary channel in this section using a first material; covering a section of the underside using a second material; sterilizing the piercing element; and attaching a test region containing detection reagents to the piercing element.
US08608668B2 Lancet protective cap
A unique technique for maintaining the sterility and integrity of a lancet tip. One or more lancet tips are sandwiched between a first web and a second web of material to protect the sterility of the lancet tips. The first and second webs are heat fused together to form a structure that covers and encapsulates the lancet tips to protect the integrity of the lancet tips. The structure is cut to form individual protective caps to detachably cover each of the lancet tips.
US08608665B2 Methods for pressure detection
A device may include a first locking mechanism configured to connect a first end of the device to a needle, a second locking mechanism configured to connect a second end of the device to a syringe, a pressure transducer, a microprocessor and a light emitting diode. The pressure transducer may be configured to measure a first pressure at a first time and a second pressure at a second time. The microprocessor may be configured to receive the first pressure and the second pressure from the pressure transducer, determine a pressure difference between the first pressure and the second pressure, and determine a time difference between the first time and the second time. The light emitting diode may be configured to signal when the needle is properly situated based on the pressure difference and the time difference.
US08608661B1 Method for intravascular delivery of a treatment agent beyond a blood vessel wall
A method including positioning a delivery device at a location in a blood vessel; advancing the delivery device a distance into a wall of the blood vessel to a treatment site beyond an external elastic lamina of the blood vessel; and after advancing the delivery device, introducing a treatment agent including a cellular component through the delivery device. A composition including a treatment agent comprising a cellular component associated with a matrix material, wherein the composition is suitable for percutaneous delivery. Also an apparatus suitable for delivering a treatment agent. Also, a kit including a treatment agent.
US08608659B2 Ultrasonic imaging apparatus
An ultrasonic imaging apparatus according to the present invention includes an ultrasonic probe (2) for receiving and transmitting ultrasonic waves from/to an object (1), ultrasound image structuring means (6) for generating an ultrasound image from a reflected echo signal received by the ultrasonic probe, elastic image structuring means (7) for obtaining a physical quantity of the elasticity of a region of the object corresponding to the ultrasound image from the reflected echo signal and generating a color elastic image, display means (9) for overlaying the ultrasound image to the color elastic image, or arranging the ultrasound image and the color elastic input means (17) for variably setting a corresponding relationship between a hue of the color elastic image and the level of the physical quantity displayed on the screen. The level of the elasticity, such as the strain of each region in the tissue or an elastic modulus, is displayed with colors in accordance with the interest of the examiner, thus improving the convenience of use.
US08608657B2 Clinical acceptance tool
Provided herein are methods and apparatuses for facilitating clinical acceptance of patient monitoring features. These methods may be used in conjunction with a computer that includes software for viewing the type of display associated with the monitoring feature. The clinical acceptance systems as provided herein may display a new or experimental monitoring feature along with a benchmark feature that a clinician is familiar with. In certain embodiments, the viewing tool may be isolated from the calculation tools so that the computer may include stored files that are in a format ready for display.
US08608656B2 System and method for integrating clinical information to provide real-time alerts for improving patient outcomes
Systems and methods for assessing a patient's risk of poor outcome in real-time are provided. The real-time risk may be used by a physician to guide decision making during a procedure.
US08608653B2 Networked system for interactive communication and remote monitoring of individuals
A system for remotely monitoring an individual. The system includes a server system for generating a script program from a set of queries. The script program is executable by a remote apparatus that displays information and/or a set of queries to the individual through a user interface. Responses to the queries that are entered through the user interface together with individual identification information are sent from the remote apparatus to the server system across a communication network. The server system also includes an automated answering service for providing a series of questions from a stored set of questions for an individual at the remote apparatus to respond to, storing responses to each provided question in the series of questions and providing a service based on the individual's response to the questions.
US08608652B2 Vaginal entry surgical devices, kit, system, and method
A surgical method, system, kit, and various devices are provided for use in, among other things, vaginal entry during a natural orifice translumenal endoscopic surgical procedure. A system and/or method provide for the rapid creation of a conduit and/or multiple ports in a natural orifice, such as a patient's vagina, while accommodating anatomical variation to reduce the need to excise additional tissue from the patient.
US08608650B2 Surgical access instruments for use with delicate tissues
Surgical instruments providing access to delicate tissue, such as brain tissue or breast tissue, through a transcutaneous incision. A surgical apparatus may have a hollow sleeve retractor extending along a longitudinal axis from a proximal retractor end to a distal retractor end and an introducer having a proximal introducer end and a distal introducer end. The proximal introducer end is configured to install within the hollow sleeve with its distal end extending beyond the distal retractor end. The distal introducer end is tapered and may have a rounded profile in a plane parallel to the longitudinal axis to displace delicate brain tissue transversely to the longitudinal axis without damage to the tissue. The distal retractor end may be blunt and adapted to support adjacent brain tissue while minimizing disruption to the tissue after the retractor is positioned at a surgery site and the introducer is removed from the retractor.
US08608645B2 Stereo-endoscope with camera connection
A stereo-endoscope is provided having a hollow shank with two axially parallel optical channels, which channels run through the hollow shank and respectively form at least a section of an image path to respective oculars of a binocular observation device arranged on the proximal end of the hollow shank. Moreover, the stereo-endoscope includes a camera connection, and one of the optical channels also forms at least one section of an image path to the camera connection.
US08608643B2 Implantable devices, tools and methods for anatomical support
An implantable device for anatomical support includes a sling, a first interconnecting member that is coupled to the sling, and a second interconnecting member that is coupled to the sling. An adjustable anchor is slidably coupled to the first interconnecting member to permit bidirectional movement along the first interconnecting member, and configured to exert a compressive force generating frictional interference between the adjustable anchor and the first interconnecting member, to inhibit the bi-directional movement of the adjustable anchor along the first interconnecting member unless sufficient force is applied to overcome the frictional interference. Also, a fixed anchor is fixedly coupled to the second interconnecting member.
US08608629B2 Therapeutic body strap
A therapeutic body strap having a first loop and a second loop. Each loop is made of a strip of material. A central strip having a fixture point such that the first and second loops are connected to the central strip at the fixture point. The strap further includes an attachment portion extending from the central strip for attachment to an attachment point on a stationary object. The first and second loops are configured to snugly surround a user's body parts to allow the user to stretch by creating a tension in the attachment portion.
US08608628B2 Hand-held exercise weight
An exercise weight includes a weight member, a handle member spaced apart from and substantially surrounding the weight member, and at least one attachment member joining the weight member to the handle member so that the weight member is located inside the handle member. The exercise weight has a relatively narrow profile, or width, to avoid contact with the body during exercise.
US08608624B2 Exercise apparatus for mobility recovery and slimming
An exercising apparatus for allowing mobility recovery and slimming activities. The apparatus is an endless belt-like exercising sport mat device which comprises a) an endless belt padded with a relatively soft and elastic material for serving as a sliding sport mat; b) a rolling mechanism for allowing the endless belt to be looped at a relatively low speed around the rolling mechanism, thereby providing a lower belt section and an overlying upper belt section on which a user may perform such activities; c) a supporting surface disposed under the inner surface of said upper belt section supporting relation thereto and depressible therewith under the weight of a user for aiding the user to move the endless belt; and d) a rigid frame for containing the supporting surface and the rolling mechanism.
US08608622B2 Systems and methods for improving motor function with assisted exercise
One embodiment of the present invention includes a system and method for alleviating symptoms of a medical disorder of a patient by forced exercise. The system includes an exercise machine having movable portions that move in response to a first contribution by a patient and in response a second contribution by a motor. The system further includes at least one mechanical sensor and a control system programmed to alter the second contribution by the motor in response to the sensed data.
US08608618B1 Method of eliminating torque interruption during mode shift
In a multiple mode continuously variable transmission having a variator, a planetary gear assembly, a low mode brake that grounds a first component of the planetary gear assembly to provide lower operating speeds and a high mode brake that grounds a second component of the planetary gear assembly to provide higher operating speeds, the method of providing a mode upshift comprising the steps of adjusting the ratio of the variator from a low ratio to a high ratio, releasing the low mode brake while simultaneously engaging the high mode brake during a torque phase of the shift and reducing the variator ratio from a high ratio to a low ratio during the inertia phase of the shift, thereby eliminating torque interruption and providing a constant torque output.
US08608616B2 Clutch control device of hybrid vehicle
A clutch control of a hybrid vehicle can engage a clutch which not otherwise possible due to temporary factors, and can determine whether engaging members of the clutch have been successfully engaged. The clutch control controls the clutch having a pair of the engaging members which are provided in a power transmission path of the vehicle, and which are moved in the axial direction and engaged or released when switching is performed between power from a motor and power from an engine. The clutch control device has a rotation control unit for synchronizing the rotations of the engaging members when the clutch is shifted from a disengaged an engaged state, and a clutch engagement control unit for determining whether the engaging members have been engaged, based on rotational speed of the engaging members a predetermined time after axial movement of the engaging members.
US08608613B2 Double-flywheel damper with epicyclic gear train
Double shock-absorbing steering wheel, in particular for automobile vehicles, comprising a primary inertia mass connected to an engine shaft (12), a secondary inertia mass (14) connected by clutch E to a gearbox BV, and a torsion damper (18) rotatably connecting the two inertia masses (10, 14), this torsion damper including an epicycloidal gear train whose outer crown wheel (22) engages with a spring (28) for absorption of vibrations and rotation acyclisms, said spring being mounted around the crown wheel (22) in a fixed frame (26).
US08608601B2 Tensioning device
ISSUE: A chain tensioning device with a short center distance that can impart a tensioning force to a plurality of chain spans at the same time with a simple structure. MEANS OF RESOLUTION: A tensioning device (1) includes a first tensioner arm (2) having an arm part (20) disposed outside a chain span (C)1 and a flange part (21) integrated with the arm part (20) and projecting toward the internal space between chain spans (C1, C2), a second tensioner arm (3) having an arm part (30) disposed outside a chain span (C2) and a flange part (31) integrated with the arm part (30), projecting toward the internal space between chain spans (C1, C2), and overlapping the flange part (21), a linking part pivotably linking the flange parts 821, 31) at the overlapping portion of the flange parts (21, 31), and a tensioner (4) urging the first tensioner arm (2) toward the chain span (C1).
US08608598B2 Boomerang
The invention relates to a boomerang that can automatically change both elevation angle α of blades and curve radius r of blades upon the change of rotary speed of blades (12), wherein blades (12) are made of elastically plastic film preferably selected from a group of polyvinyl chloride, polypropylene, polyethylene terephthalate, polystyrene and high impact polystyrene, the material has a specific weight of from about 0.9 g/cm3 to about 1.60 g/cm3 and as thickness from about 0.1 mm to about 1 mm; the ratio between the depth of the rear groove and blade width is from about 1/7 to about 6/7; the ratio between depth of the front groove and blade width is from about 0 to about 3/7; the elevation angle α0 is from about 10° to about 45°; the initial curve radius r0 of the blades is longer or equal to 1/5 of the radius R of said ring (13); the ratio between the total area of said blades and the area of a circle defined by said ring (13) is from about % to about 38%.
US08608595B2 Image-capturing apparatus for putting practice and training putter having image-capturing apparatus
An image-capturing apparatus for putting practice which is mounted on a putter provided with a head including a face for putting, a shaft, and a grip includes: an image-capturing unit provided with a camera for imaging a hole; a computation unit configured to specify a face perpendicular line which is a vertical line drawn from the center of the face, and calculate a relative relation between the hole and the face perpendicular line based on a hole image captured by the camera; a display unit configured to display the relative relation calculated by the computation unit; and a mounting unit configured to mount at least the image-capturing unit on the shaft or the grip.
US08608591B2 Golf club head
A golf club head having good forgiveness and playability characteristics includes a body defining an interior cavity. The body includes a sole positioned at a bottom portion of the golf club head, a crown positioned at a top portion, a skirt positioned around a periphery between the sole and crown, and a strike face positioned at the front of the body. The body has a forward section, a mid-section and a back section. The mass of the forward section is at least as great as the combined mass of the mid-section and back section and the mass ratio of the back section to the mid-section is greater than 80%. Some embodiments of the club head include lightweight panels positioned within openings formed in the sole and crown of the body.
US08608586B2 Golf putter
A golf club with a club head comprising a body defining a volume, a shaft coupled to the club head, and a balance point established above the sole and no further away from the sole than five inches is provided. A method for creating a club head with enhanced balance point placement can also be provided. The method can include, in a golf club formed from a club head coupled to a shaft, moving a balance point from a position between no less than seven inches and no more than eighteen inches measured from the sole along a longitudinal axis of the shaft between a butt of the shaft and a sole of the club head to a position no further away from the sole than five inches measured from the sole along a longitudinal axis of the shaft.
US08608581B2 Water slide
A slide feature is adapted to carry one or more riders and/or ride vehicles sliding thereon. The slide feature includes a sliding surface having an entry end and an exit end. The sliding surface comprising a wall defined by a portion of a side of a funnel shape, tilted sideways, the wall comprising a top and a bottom. The bottom of the wall comprising a lowermost surface of the sliding surface and is horizontal or descending from the entry end to the exit end. The top of the wall curves upward from the lowermost surface past an angle of 90 degrees to the horizontal. A radius of curvature of the sliding surface tapers from the entry end to the exit end.
US08608580B2 Adjustable stair and furniture slide
A slide assembly for indoor/outdoor use which may be adapted to mount to a stairway or furniture piece, such as a couch or chair. The slide assembly includes two or more mounting apparatuses which pivotally mount the slide to a vertical wall adjacent to a stairway such that the slide assembly is capable of being moved from an in-use position to a folded or stowed away position. The ability to pivot the slide assembly allows the stairway to be left unobstructed and free for regular use while the slide is not being used. Similarly, the slide assembly may be mounted to a couch or chair and may be easily disassembled such that the couch may be left unobstructed and free for regular use when the slide is not being used.
US08608578B2 Constant velocity joint of tripod type
A constant velocity joint comprises: a hollow housing having a plurality of guide grooves; a tripod having a plurality of trunnions positioned in the guide grooves; and a roller assembly disposed on each trunnion. The outer roller includes a convex outer surface, the convex outer surface having a first radius (Rry) seen from a cross section taken in an orthogonal direction of the outer roller, the convex outer surface having a second radius (Rrx) seen from a cross section taken along the central axis of the outer roller, in which the center of the second radius (Rrx) is displaced outwardly from the center of the first radius (Rry), and the second radius (Rrx) is shorter than the first radius (Rry).
US08608577B2 Damper device
A damper device includes a first rotation member coupled to an engine; a second rotation member coupled to a drive member driven by power generated from the engine and capable of rotating relative to the first rotation member; and a coil spring configured to transmit the power between the first rotation member and the second rotation member, and absorb a torque variation between the first rotation member and the second rotation member, wherein the coil spring has a hollow portion that is an internal area and an outline portion that is an outer area on a cross-sectional shape on a plane including a centerline of the coil spring, the hollow portion having lower rigidity and lower density than those of the outline portion. Accordingly, the damper device can reduce the influence caused by the centrifugal force.
US08608574B2 Game machine with guide path not blocked by game media
A gaming machine includes at least a cabinet, a hopper unit, an insertion slot to which a game medium is inserted, and a coin sensor that detects the game medium that has been inserted. The coin sensor is disposed directly below the insertion slot. Since the guidepath is not needed between the insertion slot and the coin sensor, such a configuration can prevent coins from blocking the guidepath.
US08608571B1 Method and system for a tracking game using multiple mobile devices
In general, a method includes receiving a first geographic location of a first mobile device, receiving a second geographic location of a second mobile device, receiving a third geographic location of a third mobile device, providing first instructions to the first mobile device for navigating toward the third geographic location, and providing second instructions to the second mobile device for navigating toward the third geographic location.
US08608567B2 Modular entertainment and gaming system configured to capture raw biometric data and responsive to directives from a remote server
A secure and modular architecture for monitoring and controlling clusters of pay entertainment and gaming devices. The architecture allows flexible and secure use of state-of-the-art multimedia and Internet technologies to attract the younger player generation used to flashy and networked games. Cash or cash-less entertainment and gaming devices are supported.
US08608566B2 Music video game with guitar controller having auxiliary palm input
A music based video game provides an auxiliary palm input on an associated guitar shaped video game controller. In some embodiments, the auxiliary palm input is positioned near a strum input on a body of the guitar shaped video game controller, allowing for simultaneous operation of both the strum input and the auxiliary palm input with one hand. In some embodiments, the auxiliary palm input modifies audio outputs generated in the music based video game. In some embodiments, the auxiliary palm input triggers an alternate game mode, for example, a bonus mode, during video game play of the music based video game.
US08608564B2 Connector for video game controller, and video game controller including the same
A connector for a video game controller including electrical circuitry and a plurality of buttons. The connector includes: a plurality of contacts for receiving and transmitting electrical signals; and a plurality of pins electrically coupled to the plurality of contacts for communicating the electrical signals with the electrical circuitry of the video game controller. The plurality of contacts includes at least one contact for receiving an electrical signal that corresponds to pressing one of the plurality of buttons from among the plurality of electrical signals.
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