Document Document Title
US08536623B2 High electron mobility transistor and method of manufacturing the same
A high electron mobility transistor (HEMT) includes a substrate, an HEMT stack spaced apart from the substrate, and a pseudo-insulation layer (PIL) disposed between the substrate and the HEMT stack. The PIL layer includes at least two materials having different phases. The PIL layer defines an empty space that is wider at an intermediate portion than at an entrance of the empty space.
US08536622B2 Semiconductor device and power supply apparatus
A semiconductor device includes a first transistor including a GaN-based semiconductor stacked structure formed over a substrate, a first gate electrode having a plurality of first fingers over the semiconductor stacked structure, a plurality of first drain electrodes provided along the first fingers, and a plurality of first source electrodes provided along the first fingers; a second transistor including the semiconductor stacked structure, a second gate electrode having a plurality of second fingers over the semiconductor stacked structure, the second drain electrodes provided along the second fingers, and a plurality of second source electrodes provided along the second fingers; a drain pad provided over or under the first drain electrodes, and coupled to the first drain electrodes; a source pad provided over or under the second source electrodes, and coupled to the second source electrodes; and a common pad coupled to the first source electrodes and the second drain electrodes.
US08536616B2 Multilayer substrate having gallium nitride layer and method for forming the same
The present invention provides a method for forming a multilayer substrate having a gallium nitride layer, wherein a mesh layer having a plurality of openings is formed on a substrate, and a buffer layer, three aluminum gallium nitride layers with different aluminum concentrations and a gallium nitride layer are formed in sequence on the substrate in the openings. The three aluminum gallium nitride layers with different aluminum concentrations are capable of releasing stress, decreasing cracks on the surface of the gallium nitride layer and controlling interior defects, such that the present invention provides a gallium nitride layer with larger area, greater thickness, no cracks and high quality for facilitating the formation of high performance electronic components in comparison with the prior art. The present invention further provides a multilayer substrate having a gallium nitride layer.
US08536614B2 Nitride semiconductor light emitting device with magnetic film
A nitride semiconductor light emitting device including an n-type nitride semiconductor layer, a p-type nitride semiconductor layer, a light emitting semiconductor layer, a first metal pad, a second metal pad, and a first magnetic material layer is provided. The light emitting semiconductor layer is disposed between the n-type nitride semiconductor layer and the p-type nitride semiconductor layer. The first metal pad is electrically connected to the n-type nitride semiconductor layer. The second metal pad is electrically connected to the p-type nitride semiconductor layer. The first magnetic material layer is disposed between the first metal pad and the n-type nitride semiconductor layer. A distribution area of the first magnetic material layer parallel to a (0001) plane of the n-type nitride semiconductor layer is greater than or equal to an area of the first metal pad parallel to the (0001) plane.
US08536613B2 Heterostructure containing IC and LED and method for fabricating the same
A heterostructure contains an IC and an LED. An IC and an LED are initially provided. The IC has at least one first electric-conduction block and at least one first connection block. The IC electrically connects with the first electric-conduction block. The first face of the LED has at least one second electric-conduction block and at least one second connection block. The LED electrically connects to the second electric-conduction block. Subsequently, the first electric-conduction block and the first connection block are respectively joined to the second electric-conduction block and the second connection block. The first electric-conduction block is electrically connected with the second electric-conduction block and forms a heterostructure. The system simultaneously provides functions of heat radiation and electric communication for the IC and LED resulting in a high-density, multifunctional heterostructure.
US08536610B2 Parallel optical transceiver module
A silicon-on-insulator wafer is provided. The silicon-on-insulator wafer includes a silicon substrate having optical vias formed therein. In addition, an optically transparent oxide layer is disposed on the silicon substrate and the optically transparent oxide layer is in contact with the optical vias. Then, a complementary metal-oxide-semiconductor layer is formed over the optically transparent oxide layer.
US08536599B2 Semiconductor light emitting device and method of fabricating thereof
A semiconductor light emitting device has a first conductive semiconductor layer, an active layer on the first conductive semiconductor layer and a second conductive semiconductor layer on the active layer. An oxide layer is disposed around the first semiconductor layer and is provided between the substrate and active layer. The first semiconductor layer has an uneven pattern along the side edge.
US08536598B2 Semiconductor light emitting device and fabrication method for the same
A high luminance semiconductor light emitting device and fabrication method thereof, wherein a metallic reflecting layer is formed using a non-transparent semiconductor substrate. The device includes a light emitting diode structure on a GaAs substrate structure bonded together using a first and a third metal layers. The substrate includes a GaAs layer, a first metal buffer layer on a surface of the GaAs layer, the first metal layer on the first metal buffer layer, and a second metal buffer layer and a second metal layer at a back side of the GaAs layer. The diode structure includes the third metal layer, a metal contact layer on the third metal layer, a p-type cladding layer on the metal contact layer, a multi-quantum well layer on the p-type cladding layer, an n-type cladding layer on the multi-quantum well layer, and a window layer on the n-type cladding layer.
US08536597B2 Light emitting diode with peripheral circular slots and method for manufacturing the same
A light emitting diode chip includes an electrically conductive substrate, a reflecting layer disposed on the substrate, a semiconductor structure formed on the reflecting layer, an electrode disposed on the semiconductor structure, and a plurality of slots extending through the semiconductor structure. The semiconductor structure includes a P-type semiconductor layer formed on the reflecting layer, a light-emitting layer formed on the P-type semiconductor layer, and an N-type semiconductor layer formed on the light-emitting layer. A current diffusing region is defined in the semiconductor structure and around the electrode. The slots are located outside the current diffusing region.
US08536595B2 Solid state lighting devices with low contact resistance and methods of manufacturing
Solid state lighting (“SSL”) devices with improved contacts and associated methods of manufacturing are disclosed herein. In one embodiment, an SSL device includes a first semiconductor material, a second semiconductor material spaced apart from the first semiconductor material, and an active region between the first and second semiconductor materials. The SSL device also includes a contact on one of the first or second semiconductor materials. The contact includes a first conductive material and a plurality of contact elements in contact with one of the first or second conductive materials. The contact elements individually include a portion of a second conductive material that is different from the first conductive material.
US08536592B2 LED package device
An LED package device having a dam located on a substrate is provided, by which two regions are defined on the substrate. Two LED dies are respectively disposed on the two regions and separated by the dam; therefore, the LED package device has an enhanced intensity of the lateral-emitting light and a wide light emitting angle. The LED package devices can be used in backlight units to prevent mura and hot spot issues.
US08536591B2 Light emitting device and lighting system
A light emitting device may be provided that includes a conductive support member; a first conductive layer disposed on the conductive support member; a second conductive layer disposed on the first conductive layer; a light emitting structure including a second semiconductor layer formed on the second conductive layer, an active layer formed on the second semiconductor layer, a first semiconductor layer formed on the active layer and an insulation layer. The first conductive layer includes at least one via penetrating the second conductive layer, the second semiconductor layer and the active layer and projecting into a certain area of the first semiconductor layer. The first semiconductor layer includes an ohmic contact layer formed on or above the conductive via. The insulation layer is formed between the first conductive layer and the second conductive layer and is formed on the side wall of the via.
US08536589B2 Display device for controlling an organic light emitting layer thickness
A display device includes an array of light emitting cells. Each light emitting cell includes first and second electrodes, and an organic light emitting layer located between the first and second electrodes. Banks are above the first electrode that partition the organic light emitting layer to define each of the light emitting cells. First and second light emitting cells are adjacent to one another and located in a peripheral region of the array. The first light emitting cell is closer to a center of the array than the second light emitting cell. A first bank borders the first light emitting cell and the second light emitting cell. An inclination angle of an innermost sidewall of the first bank that is adjacent the first light emitting cell is greater than an inclination angle of an outermost sidewall of the first bank that is adjacent the second light emitting cell.
US08536587B2 Method and apparatus for measurement and control of photomask to substrate alignment
A method, structure, system of aligning a substrate to a photomask. The method includes: directing incident light through a pattern of clear regions transparent to the incident light in an opaque-to-the-incident-light region of a photomask, through a lens and onto a photodiode formed in a substrate, the photodiodes electrically connected to a light emitting diode formed in the substrate, the light emitting diode emitting light of different wavelength than a wavelength of the incident lights; measuring an intensity of emitted light from light emitting diode; and adjusting alignment of the photomask to the substrate based on the measured intensity of emitted light.
US08536586B2 Light emitting device package and light unit having the same
Disclosed is an LED package. The LED package includes a package body, a first frame and a second frame on the package body and a light emitting device chip on the first frame. The first frame is separated from the second frame, and the first frame includes a bottom frame on the package body and at least two sidewall frames extending from the bottom frame and inclined with respect to the bottom frame.
US08536585B2 Semiconductor light emitting device including anode and cathode having the same metal structure
A semi-conductor light emitting device 10 in the present invention comprises an n-type ZnO substrate 3, an emission layer 2, anode 5, and cathode 4. The n-type ZnO substrate 3 has a mounting surface 31 on one of its surfaces. The emission layer 2 is composed of a p-type GaN film 24 and an n-type GaN film 22, and superimposed on the n-type ZnO substrate 3 with the p-type GaN film 24 directly disposed on the mounting surface 31 of the n-type ZnO substrate 3. The anode 5 is disposed directly on the mounting surface 31 of the n-type GaN substrate 3 in an ohmic contact therewith and in a spaced relation from the emission layer. The cathode 4 is disposed on the n-type GaN film 22 in an ohmic contact therewith. The cathode 4 and anode 5 are of the same structure solely composed of a metallic material. The semi-conductor light emitting device in the present invention assures good ohmic contact of both the cathode 4 and the anode 5, and minimizes consumption of metallic materials.
US08536584B2 High voltage wire bond free LEDS
An LED chip and method of fabricating the same is disclosed that comprises a plurality of sub-LEDs, said sub-LEDs interconnected such that the voltage necessary to drive said sub-LEDs is dependent on the number of said interconnected sub-LEDs and the junction voltage of said sub-LEDs. Each of said interconnected sub-LEDs comprising an n-type semiconductor layer, a p-type semiconductor layer, and an active or quantum well region interposed between the n-type and p-type layers. The monolithic LED chip further comprising a p-electrode having a lead that is accessible from a point on a surface opposite of a primary emission surface of the monolithic LED chip, the p-electrode electrically connected to the p-type layer, and an n-electrode having a lead that is accessible from a point on the surface opposite of the primary emission surface, the n-electrode electrically connected to the n-type layer. These sub-LEDs interconnected by at least a metallization layer on the n-type and p-type layers, which is insulated so that it does not short the sub-LEDs. Further, the LED chip is capable of being electrically coupled for operation without wire bonds.
US08536583B2 MOSFET and method for manufacturing MOSFET
A MOSFET includes: a silicon carbide (SiC) substrate having a main surface having an off angle of not less than 50° and not more than 65° relative to a {0001} plane; a semiconductor layer formed on the main surface of the SiC substrate; and an insulating film formed in contact with a surface of the semiconductor layer. The MOSFET has a sub-threshold slope of not more than 0.4 V/Decade.
US08536581B2 Semiconductor device and method of manufacturing the same
In a semiconductor device, gate signal lines are spaced apart from each other above a crystalline semiconductor film. Therefore a first protective circuit is not electrically connected when contact holes are opened in an interlayer insulating film. The static electricity generated during dry etching for opening the contact holes moves from the gate signal line, damages a gate insulating film, passes the crystalline semiconductor film, and again damages the gate insulating film before it reaches the gate signal line. As the static electricity generated during the dry etching damages the first protective circuit, the energy of the static electricity is reduced until it loses the capacity of damaging a driving circuit TFT. The driving circuit TFT is thus prevented from suffering electrostatic discharge damage.
US08536577B2 Display device
The present invention provides an active matrix type display device having a high aperture ratio and a required auxiliary capacitor. A source line and a gate line are overlapped with part of a pixel electrode. This overlapped region functions to be a black matrix. Further, an electrode pattern made of the same material as the pixel electrode is disposed to form the auxiliary capacitor by utilizing the pixel electrode. It allows a required value of auxiliary capacitor to be obtained without dropping the aperture ratio. Also, it allows the electrode pattern to function as a electrically shielding film for suppressing the cross-talk between the source and gate lines and the pixel electrode.
US08536574B2 Thin film transistor and method of manufacturing the same
In an exemplary embodiment, a thin film transistor array panel includes: a substrate; a gate line on the substrate; a gate driver on a peripheral area of the substrate; a gate pad formed on the substrate and connecting the gate line and the gate driver; a gate insulating layer formed on the gate line and the gate pad; a data line formed on the gate insulating layer and including a source electrode and a facing drain electrode; a height controlling member corresponding to the gate pad and formed on the gate insulating layer; a passivation layer on the gate insulating layer, the data line, the drain electrode, the gate pad, and the height controlling member; an insulating layer on the passivation layer; a pixel electrode formed on the insulating layer and connected to the drain electrode; and contact assistants connected to the gate pad and the height controlling member.
US08536572B2 Assembled multi-component electronic apparatus using alignment and reference marks
The present invention relates generally to assembly techniques. According to the present invention, the alignment and probing techniques to improve the accuracy of component placement in assembly are described. More particularly, the invention includes methods and structures to detect and improve the component placement accuracy on a target platform by incorporating alignment marks on component and reference marks on target platform under various probing techniques. A set of sensors grouped in any array to form a multiple-sensor probe can detect the deviation of displaced components in assembly.
US08536569B2 Light emitting element and light emitting device using the element
A first light emitting element 310 and a second light emitting element 320 are serially laminated over a substrate 300. The first light emitting element 310 has a light emitting layer 312 between a first anode 311 and a first cathode 313, and the second light emitting element 320 has a light emitting layer 322 between a second anode 321 and a second cathode 323. Here, the light emitting layer 312 shows a first emission spectrum 330 having peaks both in a blue to blue green wavelength range and in a yellow to orange wavelength range, and the light emitting layer 322 shows a second emission spectrum 340 having peaks both in a blue green to green wavelength range and in an orange to red wavelength range.
US08536551B2 Extreme ultra violet light source apparatus
An extreme ultraviolet light source apparatus using a spectrum purity filter capable of obtaining EUV light with high spectrum purity. The apparatus includes a chamber; a target supply unit for supplying a target material; a driver laser using a laser gas containing a carbon dioxide gas as a laser medium, for applying a laser beam to the target material to generate plasma; a collector mirror for collecting and outputting the extreme ultraviolet light radiated from the plasma; and a spectrum purity filter provided in an optical path of the extreme ultraviolet light, for transmitting the extreme ultraviolet light and reflecting the laser beam, the spectrum purity filter including a mesh having electrical conductivity and formed with an arrangement of apertures having a pitch not larger than a half of a shortest wavelength of the laser beam applied by the driver laser.
US08536546B2 Carbon nanotube electron gun
An electron gun, an electron source for an electron gun, an extractor for an electron gun, and a respective method for producing the electron gun, the electron source and the extractor are disclosed. Embodiments provide an electron source utilizing a carbon nanotube (CNT) bonded to a substrate for increased stability, reliability, and durability. An extractor with an aperture in a conductive material is used to extract electrons from the electron source, where the aperture may substantially align with the CNT of the electron source when the extractor and electron source are mated to form the electron gun. The electron source and extractor may have alignment features for aligning the electron source and the extractor, thereby bringing the aperture and CNT into substantial alignment when assembled. The alignment features may provide and maintain this alignment during operation to improve the field emission characteristics and overall system stability of the electron gun.
US08536544B2 Apparatus and a method of determining the presence of an alumina layer on a surface of a component
Provided is a method for determining the presence of an alumina layer on a surface of a component. The method includes illuminating a surface of a component with radiation; detecting radiation emitted at a particular wavelength; analyzing the detected radiation; to determine the thickness of the alumina at at least one point on the surface of the component; and comparing the determined thickness of the alumina at the at least one point on the surface of the component with a predetermined thickness of alumina at that point to decide if the thickness of alumina at the at least one point on the surface of the component is satisfactory.
US08536537B2 Adjustable medical imaging device
A medical imaging device is provided. The medical imagining device includes an object support; a handle; a radiation source configured to emit radiation from a plurality of positions about the object support, wherein the positions are located substantially in a plane; a radiation detector configured to detect the radiation emitted by the radiation source; and displacement means configured to shift the handle relative to the radiation detector and to the radiation source.
US08536532B1 Upconverting nanoparticles for optimizing scintillator based detection systems
An upconverting device for a scintillation detection system is provided. The detection system comprises a scintillator material, a sensor, a light transmission path between the scintillator material and the sensor, and a plurality of upconverting nanoparticles particles positioned in the light transmission path.
US08536529B2 Non-contact surface chemistry measurement apparatus and method
A surface chemistry measuring apparatus includes a processor, an array of tunable infrared laser spectrometers interfacing with the processor and configured for simultaneous measurement of surface chemistry across a surface to be measured using a range of infrared wavelengths and a display interfacing with the processor and adapted to display IR spectra of infrared wavelengths reflected from the surface to be measured.
US08536528B2 System and method for downhole voltage generation
A system for supplying voltage to a downhole component is disclosed. The system includes: a pyroelectric material disposed in electrical communication with the component, the component configured to be disposed within a borehole in an earth formation; and a heating unit in operable communication with the pyroelectric material and configured to change a temperature of the pyroelectric material and cause the pyroelectric material to generate a voltage to activate the component. A method of supplying voltage to a downhole component is also disclosed.
US08536523B2 Desorption and ionization method and device
The present invention involves a method and a device for sequentially desorbing and ionizing mixed analytes on a solid surface with a gradual temperature scan, and continuously collecting data for multiple times in the gradual desorption and ionization process. By gradually increase the temperature of at least one part of the sample, the analytes with different thermal desorption capabilities are sequentially desorbed from surfaces of the solid sample, thereby providing a sample pre-separation scheme, so as to reduce difficulties to subsequent mass spectrum detection. Meanwhile, since mass spectrum data of the analytes with different boiling points is collected for multiple times during a temperature scan, the analytes with a low boiling point can be detected first at lower temperature in order to avoid rapid exhaustion at higher temperature, thereby improving the detection efficiency of the analytes with low boiling points.
US08536522B2 Mass spectrometer
A detachable and replaceable ion source for a mass spectrometer. The ion source comprises a housing which defines an ion source chamber, an ion source mounting means complementary to mounting means on the mass spectrometer to detachably couple with the mass spectrometer. This allows movement of the housing to bring the ion source chamber into a position of use at the inlet of said mass spectrometer and to take the ion source chamber from said position of use into a retracted position. Sealing means is provided to create an air tight seal between the housing and the mass spectrometer when the ion source chamber is in its position of use. A release mechanism is provided which cooperates with the mass spectrometer to allow the said movement of said housing.
US08536519B2 Adjusting the detector amplification in mass spectrometers
The amplification of secondary-electron multipliers in mass spectrometers is automatically adjusted by generating mass spectra with single ion signals, determining the average value of the peak heights of these single ion signals, and setting the amplification so that the average peak height assumes a desired nominal value. The amplification may be set via the supply voltage of the secondary-electron multiplier and can be increased or decreased by a desired factor using the known characteristic of the secondary-electron multiplier.
US08536517B2 Scintillator based radiation detection
Methods and related systems are described for the detection of nuclear radiation. The system can include a tool body adapted to be deployed in a wellbore and a scintillator material that intrinsically generates radiation. The scintillator material is mounted within the tool body. A photodetection system is coupled to the scintillator material, and mounted within the tool body. Features in a spectrum associated with a scintillation material's intrinsic radioactive decay are used for the determination of one or more parameter's of the response function of the radiation detector system.
US08536515B2 Method for determining a dose of radiation and method for determining an associated isodose curve
A method for determining a radiation dose emitted by a source of fissile material in an installation comprising a set of walls perpendicular to a horizontal plane, characterized in that it comprises the determination from descriptive geometrical data of the installation, of intersection points between a calculation line and characteristic lines formed from a set of characteristic planes perpendicular to the horizontal plane and each containing a point source representative of the source and at least one junction edge between two walls perpendicular to the source plane.
US08536513B2 Space-saving flatbed scanner
A space-saving scanner assembly and method are disclosed. The scanner assembly can be manufactured with optical scanning components typical of flatbed scanners. The scanner may be enclosed within a housing a substantially vertical source-contact surface with a channel and a flap coupled to the source-contact surface. The flap having a source-backing surface substantially parallel to the source-contact surface of the housing and arranged such that the source-contact surface, the source-backing surface, and the channel form an opening for receiving an edge of a source document to be scanned. The housing and the flap are configured with a number of features, which permit an operator to easily place a source over a platen forming a portion of the source-contact surface. A method for operating a space-saving scanner is also presented. The method can be broadly summarized by the following steps: providing a scanner with a housing with a substantially vertical source-contact surface and a channel extending therefrom, the vertical source-contact surface including a transparent platen portion, the channel adjacent to a lower edge of the transparent platen; and providing a flap coupled to the source-contact surface, the flap having a source-backing surface substantially parallel to the source-contact surface of the housing, wherein the source-contact surface, the source-backing surface, and the channel form an opening for receiving an edge of a source to be scanned.
US08536511B2 Light sensing device having a color sensor and a clear sensor for infrared rejection
A light sensing device has a first filter to block visible light in a light path. The light sensing device also has a first color sensor and a clear sensor, to detect light in the light path after the first filter. A light intensity calculator computes a measure of the intensity of visible light in the light path, based on a difference between (a) an output signal of the first color sensor, and (b) an output signal of the clear sensor. Other embodiments are also described and claimed.
US08536508B2 High-probability heralded single-photon source and related method
A system and method is provided for a source for a heralded single photon comprising a correlated photon-pair generator that provides bursts of multiple photon pairs that may be odd or even in number of pairs, one of each pair having a first but not a second characteristic and the other of each pair having the second but not the first characteristic; a first optical path for photons of pairs having the first characteristic; a second optical path for photons of pairs having the second characteristic; a two-photon absorber in the first optical path that, for each burst of photons, reduces the number of first characteristic photons in the first path to zero or one, depending on whether the number of photon pairs in the burst is even or odd; a photon detector in the second path having a heralding signal output to indicate when the number of photons in the burst is odd; and an optical switch coupled to the output of the second optical path and connected to operate in response to the heralding signal.
US08536506B2 Imaging device and method for high-sensitivity optical scanning and integrated circuit therefor
An inspection system includes a CMOS integrated circuit having integrally formed thereon an at least two dimensional array of photosensors and providing an inspection output representing an object to be inspected. A defect analyzer is operative to receive the inspection output and to provide a defect report.
US08536505B2 Movable illuminance sensors for fixture light sources
A lighting system including fixture lamps, e.g., ceiling mounted, and movable light sources, e.g., task lamps. The task lamps include illuminance sensors arranged to detect ambient light including light emitted by one or more fixture lamps and available daylight. Control data is generated based at least in part on the illuminance data. The resulting control data is transmitted from the task lamp to a fixture lamp and a window system so that it can be used to control the amount of light emitted by the fixture lamp and amount of daylight transmitted through the window system. This arrangement allows daylight harvesting while ensuring that the amount of light provided to workspaces (at which task lamps are located) is satisfactory.
US08536504B2 Terrestrial solar tracking photovoltaic array with chain drive
The terrestrial solar tracking photovoltaic array includes a longitudinal support that may be constructed of discrete sections. The overall length of the array may be adjusted depending upon the necessary size of the array. A drive may be configured to rotate the longitudinal support in first and second directions about a first axis. Solar cell modules are positioned along the longitudinal support and may each include a rectangular case with a plurality of lenses that are positioned over corresponding receivers. Linkages may be connected to the solar cell modules and are axially movable along the longitudinal support to rotate the solar cell modules within second planes that each orthogonal to the first plane to further track the sun during the course of the day. The array may be configured to facilitate rotation about the first axis. The array may be constructed with a center of gravity of the array to extending through the longitudinal support.
US08536503B2 Faceted retro-mirror for line-of-sight jitter sensing
A jitter sensing mechanism for a gimbaled optical sensor system. In one example, the jitter sensing mechanism includes a faceted retro-mirror configured to allow a double-pass line-of-sight monitoring beam to sense line-of-sight jitter in a multi-axis gimbaled optical sensor system where the inner-most gimbal axis includes a 2:1 gain mirror.
US08536500B2 System and method for rapid aiming and firing of defensive countermeasures
A system and method for rapid aiming and firing of weapons and defensive countermeasures against rocket-propelled grenades or other ballistic devices suitable for use on aircraft, ground vehicles, and ships.
US08536499B2 Power supply for radio frequency heating apparatus
An RF generator power supply comprises a first switched mode power supply (SMPS) connected in series to a second SMPS by a DC bus. A capacitor is arranged between the outputs of the first SMPS and inputs of the second SMPS to act as a smoothing capacitor for the first SMPS and to supply pulse energy to the second SMPS. The second SMPS has an output connected to an input of a step-up transformer and an output of the step-up transformer is connected to an input of a rectifier connectable to the RF generator. An input of the first SMPS is connectable to a prime power supply to maintain a high power factor with low harmonic content while setting an operating voltage and peak current level for the RF generator. The second SMPS is arranged to feed the step-up transformer and is arranged to operate with a variable duty cycle and/or variable frequency to provide average power control of the RF generator. The second SMPS is rapidly switched off on detection of a power surge through the RF generator.
US08536497B2 Methods for forming long subsurface heaters
A method for forming a longitudinal subsurface heater includes longitudinally welding an electrically conductive sheath of an insulated conductor heater along at least one longitudinal strip of metal. The longitudinal strip is formed into a tubular around the insulated conductor heater with the insulated conductor heater welded along the inside surface of the tubular.
US08536495B2 Device for regulated water heating using the energy gained by photovoltaic cells
Direct current power gained by photovoltaic cells can be used for heating water in a boiler. Simple installation allows use for domestic or industrial purposes, with a minimal impact to building construction. At the time of lack of sunlight intensity, water heating is provided by gas, or other heating source, or by use of a heating coil supplied by alternating current for that heating. When sunlight intensity is high, the photovoltaic cells of the present invention can be used alone. However, the source of the direct current has to be properly dimensioned in dependence on the volume of the boiler. An output 1 kWh of the source of the direct current gained by photovoltaic cells can be used to heat water of a volume of 100 L.
US08536494B2 Method and apparatus for controlling the spatial temperature distribution across the surface of a workpiece support
A chuck for a plasma processor comprises a temperature-controlled base, a thermal insulator, a flat support, and a heater. The temperature-controlled base has a temperature below the desired temperature of a workpiece. The thermal insulator is disposed over the temperature-controlled base. The flat support holds a workpiece and is disposed over the thermal insulator. A heater is embedded within the flat support and/or disposed on an underside of the flat support. The heater includes a plurality of heating elements that heat a plurality of corresponding heating zones. The power supplied and/or temperature of each heating element is controlled independently.
US08536493B1 Vertically stacked air impingement tunnel oven
A vertically stacked air impingement tunnel oven including a plurality of baking cases having vertically aligned food ports; an electronically controlled heater system connected to the baking cases, the heater system being adapted for heating selected groups of baking cases, the heater system including a plurality of on/off switches which are correspondingly electrically connected for actuating the heating of the selected baking cases; an exhaust hood and exhaust fan having an inlet over the food ports; and a first electronic motor drive system connected operatively to the exhaust fan, and being adapted for rotating the exhaust fan a rotation speed among a plurality of preset rotation speeds, the drive system including the plurality of on/off switches which are further electrically connected for simultaneously actuating the exhaust fan at rotation speeds corresponding with the selected baking case group.
US08536484B2 Laser engravers with a masking mechanism
Laser engravers with a masking mechanism comprise a machine body, a laser-engraving mechanism inside the machine body, a working platform, and an exhauster. The laser-engraving mechanism includes a lens-cart rail that moves back and forth along a working track. The exhauster includes air outlets behind the working platform. The masking mechanism, which includes a reelable curtain-sheet, is installed above the air outlets so that while processing, the curtain-sheet is reeled out above the working platform and an air induction channel is formed to increase the working efficiency of the exhauster.
US08536483B2 Methods for stripping and modifying surfaces with laser-induced ablation
A coating removal apparatus removes a coating from a surface. The apparatus has a movable scanning head and scanning optics. The scanning head is movable in one dimension, and the scanning optics adjust in two dimensions to compensate for movement of the scanning head to implement long range scanning with a uniform scanning pattern. Further, a surface roughness is determined by measuring specular and scattered reflections at various angles. For composite surfaces, the apparatus utilizes UV laser radiation and a controlled atmosphere to remove coating and alter the chemical characteristics at the surface.
US08536481B2 Electrode assemblies, plasma apparatuses and systems including electrode assemblies, and methods for generating plasma
Electrode assemblies for plasma reactors include a structure or device for constraining an arc endpoint to a selected area or region on an electrode. In some embodiments, the structure or device may comprise one or more insulating members covering a portion of an electrode. In additional embodiments, the structure or device may provide a magnetic field configured to control a location of an arc endpoint on the electrode. Plasma generating modules, apparatus, and systems include such electrode assemblies. Methods for generating a plasma include covering at least a portion of a surface of an electrode with an electrically insulating member to constrain a location of an arc endpoint on the electrode. Additional methods for generating a plasma include generating a magnetic field to constrain a location of an arc endpoint on an electrode.
US08536479B2 Method for welding shafts on vertical rotational axis
A first tubular, inner radial annular seam is produced to weld together two hollow cylinders by narrow-gap tungsten inert gas arc welding. Narrow-gap metal gas-shielded arc welding is used to create another tubular, outer radial annular seam to further weld together both hollow cylinders. In this manner, the rotational axis of the rotor shaft remains vertically aligned throughout the entire production method of welding together the shaft parts. In this manner, the required production time can be advantageously reduced and the use of welding filler can be effectively decreased.
US08536477B2 Slide control key with elastic return
A control assembly for an electronic device includes a housing, a control key, and an elastic member. The housing defines a groove. The control key is slidably positioned in the groove. The elastic member includes a plate portion and at least one elastic arm. The control key brings the elastic member to move to contact a switch, and the at least one elastic arm provides a return force to return the control key.
US08536475B2 Integrated en-style auxiliary barrier connector
Techniques disclosed herein include a conversion technique that converts an aircraft circuit breaker having male auxiliary connectors (micro switch connectors) to an aircraft circuit breaker having female auxiliary connectors, such as those conventionally used on European-made aircraft. Techniques include adding a barrier to a conventional aircraft circuit breaker approved for U.S. markets. This barrier includes female auxiliary connectors integrated with the barrier, as well as a flexible circuit that connects the male connectors with the female connectors such that the female connectors can still receive separate male connectors in the female receptacles. Such a technique converts conventional aircraft circuit breakers into a European-style breaker without requiring a full European rebuild and re-qualification. Embodiments can include single and multiple phase versions, and configurations for use with high and low amperage.
US08536474B2 Rotary switch
A rotary switch includes a rotor that is insert molded so upper and lower contact pieces have a predetermined number of contact regions with a predetermined angular width in each of a plurality of annular zones defined by a plurality of concentric circles and are stacked in a disk part. The contact pieces are exposed in two surfaces of the disk part, an upper contactor holder and a lower contactor holder are placed to cover a lower half and an upper half of the disk part of the rotor. A plurality of elastic contacts are brought into elastic contact with lower and upper side surfaces of the disk part in a plurality of annular zones, and a rotating operation shaft is inserted through the rotor, the lower contactor holder, and the upper contactor holder, and can rotate the rotor.
US08536467B2 Connecting structure for electric cables and electric apparatus
A circuit substrate for connection is used as a connecting member for electrically connecting a stator disposed inside a casing and a plurality of electric cables disposed outside the casing. A circuit substrate for connection is supported by a connecting member attachment. The connecting member attachment is molded using a circuit substrate for connection and a receptacle as inserts. Then, the circuit substrate for connection is disposed to pass through a wall portion of the casing in a thickness direction of the wall portion. The connecting member attachment is fixed onto the casing. Thus, the electric cables may be connected to the outside of the casing with a low-priced connecting structure.
US08536457B2 Multilayer wiring board and method for manufacturing the same
A wiring board including a main substrate having a base material and a conductive pattern formed on the base material, and a flex-rigid printed wiring board provided to the main substrate and having a rigid substrate and a flexible substrate connected to each other. The flex-rigid printed wiring board has a conductive pattern formed on the rigid substrate and/or the flexible substrate. The conductive pattern of the main substrate is electrically connected to the conductive pattern of the flex-rigid printed wiring board.
US08536456B2 Printed circuit board
A printed circuit board includes a first signal layer, a first reference layer, a second signal layer, and a third signal layer in that order and includes a first slanted via and a second slanted via. The first signal layer includes an parallel first transmission wire and a second transmission wire. The first and second transmission wires are coupled with each other and cooperatively constitute a first differential pair with an edge-coupled structure. The second signal layer includes a third transmission wire. The third signal layer includes a fourth transmission wire parallel to and coupled with the third transmission wire. The third and fourth transmission wires cooperatively constitute a second differential pair with a broadside-coupled structure. The first slanted via obliquely are interconnected between the first transmission wire and the third transmission wire. The second slanted via obliquely are interconnected between the second transmission wire and the fourth transmission wire.
US08536452B2 Adjustable variable ring for electrical junction boxes
An adjustable variable ring for electrical junction boxes including a base frame having a guide tab, a sliding insert having a box shaped frame, the sliding insert being configured to slide in and out of the base frame. A ratchet mechanism having a ratchet plate on the base frame including a plurality of steps, and a ratchet spring installed on an inner wall of the box shaped frame including an angled end tab and an angled mid tab protruding from the box shaped frame for engaging one or more of the plurality of steps. The sliding insert is configured to slide in and out of the base frame by disengaging the mid tab from the one or more of the steps by pressing on the end tab, and locks in the base frame by engaging the mid tab with the one or more of the steps.
US08536447B2 Electrode of solar cell and fabricating method thereof
A fabricating method of an electrode of a solar cell includes forming a first electrode layer on a photoelectric conversion layer, forming an antireflective layer on the photoelectric conversion layer to cover the first electrode layer, forming a second electrode layer on the antireflective layer, and performing a sintering process. A material of the first electrode layer does not react with the photoelectric conversion layer and the antireflective layer during the sintering process, while at least a material of the second electrode layer reacts with the antireflective layer during the sintering process. The sintering process is performed, such that the second electrode layer reacts with the antireflective layer, and the second electrode layer penetrates the antireflective layer to electrically connect the first electrode layer.
US08536444B2 Alternating bias hot carrier solar cells
Extremely high efficiency solar cells are described. Novel alternating bias schemes enhance the photovoltaic power extraction capability above the cell band-gap by enabling the extraction of hot carriers. In conventional solar cells, this alternating bias scheme has the potential of more than doubling their yielded net efficiency. In solar cells incorporating quantum wells (QWs) or quantum dots (QDs), the alternating bias scheme has the potential of extending such solar cell power extraction coverage, possibly across the entire solar spectrum, thus enabling unprecedented solar power extraction efficiency. Within such cells, a novel alternating bias scheme extends the cell energy conversion capability above the cell material band-gap while the quantum confinement structures are used to extend the cell energy conversion capability below the cell band-gap. Light confinement cavities are incorporated into the cell structure to allow the absorption of the cell internal photo emission, thus further enhancing the cell efficiency.
US08536438B2 Effector affixing device
An effector affixing device affixes an acoustic effector on a plate material. The effector affixing device includes an effector affixing base and a separation member. The effector affixing base is provided with an effector affixing component. The separation member includes supports erected below the vicinities of four corners of the effector affixing base. The effector affixing base and the separation member are separably coupled with each other. The effector affixing base includes a bottom plate and an effector holding piece. The bottom plate supports the effector. The effector holding piece is erected from an edge portion of the bottom plate. The effector affixing device includes a separation space having a height that at least allows shield lines to intersect with each other below the bottom plate in a state that the effector affixing base is coupled with upper portions of the supports.
US08536437B2 Musical score playing device and musical score playing program
The musical score playing device includes a display unit 3 made up of a touch panel, a musical score image source selecting unit 10, a musical symbol detecting unit 14 detecting at least a note position and pitch information from a musical score image source, a display device 17 displaying the selected musical score image and a playing pointer 5 on the display unit 3, a touch position detecting unit 23 detecting a touch operation position on the display unit 3, a moving means moving a position of the playing pointer 5 in correspondence to the touch operation position, and a musical sound preparing unit 31 emitting a musical sound of a pitch of a note corresponding to the playing pointer position at a timing that is in accordance with the movement of the playing pointer.
US08536436B2 System and method for providing music based cognitive skills development
The present invention provides systems and methods for providing music based cognitive skills development. More particularly the present invention may provide a music based cognitive skills development platform. The platform is provided using computer implemented systems and methods for training a human subject so as to enhance his/her intelligence, attention, language skills and brain functioning. The present invention provides these benefits using exercises, one or more of which are based on musical training aspects, however, in addition to musical training other cognitive skills development exercises may be used, as described herein. The invention may be utilized by users of varying musical skills and may be presented at a level corresponding to the prior musical training (if any) of a user, and in a form corresponding to the cognitive capacity, interests and attention span of a user.
US08536430B2 Fine tuning means for fulcrum tremolo
Apparatus, such as a stringed musical instrument, is provided with intonation modules that include a novel fine-tuning invention that eliminates modifying strings required of prior art comprising an improved clamping element, a hollow tube element forming a tailpiece at one end furthest the second critical point and a novel adaptor plate element connected to a base plate. Clamping the sting renders the string substantially inextensible between the clamping point and the tailpiece formed at the end of the hollow. Threading the string through the hollow tube portion delivers the string over the second critical point effortlessly. The hollow portion of the string holder element is threadedly engaged with an adjustment knob and makes bearing contact with adaptor plate for fine-tuning. The adaptor plate can be added to a unitary component forming the base plate and can provide other functions. Reverse threaded screws intonation module attachment screws are provided to complete a comprehensive base plate/intonation module format that integrates to a common standard all elements of the two otherwise disparate two primary vintage fulcrum tremolo designs except for riser post spacing. An improved ball bearing arrangement is also disclosed.
US08536429B2 Polynucleotides encoding a NAX2 polypeptide and methods for enhancing salinity tolerance in plants
The present invention relates to polypeptides, and polynucleotides encoding therefor, with cation transporter activity. In particular, the present invention relates to methods for producing, identifying, and/or breeding transgenic or non-transgenic plants, especially wheat or barley plants, with enhanced tolerance to saline and/or sodic soils, and/or reduced sodium accumulation in an aerial part of the plant. Also provided are plants produced using these methods.
US08536427B1 Maize variety hybrid X90A810
A novel maize variety designated X90A810 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X90A810 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X90A810 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X90A810, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X90A810. This invention further relates to is methods for producing maize varieties derived from maize variety X90A810.
US08536421B1 Maize variety inbred PH1CDJ
A novel maize variety designated PH1CDJ and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1CDJ with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1CDJ through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1CDJ or a locus conversion of PH1CDJ with another maize variety.
US08536419B2 Pepper hybrid E420088
Hybrid pepper cultivar designated E420088 which is a bell pepper type and suitable for covered cultivation, is disclosed. The invention provides green bell pepper fruit which has a sweet taste comparable to that of ripe bell peppers due to increased glucose and fructose contents. The invention relates to the seeds of hybrid pepper cultivar E420088 and to the plants of hybrid pepper cultivar E420088. The invention also relates to methods for producing a pepper plant, either inbred or hybrid, by crossing the hybrid cultivar E420088 with itself or another pepper cultivar. The invention further relates to methods for producing other pepper cultivars derived from the hybrid E420088.
US08536416B2 Soybean variety XB23K11
A novel soybean variety, designated XB23K11 is provided. Also provided are the seeds of soybean variety XB23K11, cells from soybean variety XB23K11, plants of soybean XB23K11, and plant parts of soybean variety XB23K11. Methods provided include producing a soybean plant by crossing soybean variety XB23K11 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB23K11, methods for producing other soybean varieties or plant parts derived from soybean variety XB23K11, and methods of characterizing soybean variety XB23K11. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB23K11 are further provided.
US08536414B2 Soybean variety XB09P11
A novel soybean variety, designated XB09P11 is provided. Also provided are the seeds of soybean variety XB09P11, cells from soybean variety XB09P11, plants of soybean XB09P11, and plant parts of soybean variety XB09P11. Methods provided include producing a soybean plant by crossing soybean variety XB09P11 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB09P11, methods for producing other soybean varieties or plant parts derived from soybean variety XB09P11, and methods of characterizing soybean variety XB09P11. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB09P11 are further provided.
US08536413B2 Soybean variety XB06M11
A novel soybean variety, designated XB06M11 is provided. Also provided are the seeds of soybean variety XB06M11, cells from soybean variety XB06M11, plants of soybean XB06M11, and plant parts of soybean variety XB06M11. Methods provided include producing a soybean plant by crossing soybean variety XB06M11 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB06M11, methods for producing other soybean varieties or plant parts derived from soybean variety XB06M11, and methods of characterizing soybean variety XB06M11. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB06M11 are further provided.
US08536412B1 Soybean variety XB50F08
According to the invention, there is provided a novel soybean variety designated XB50F08. This invention thus relates to the seeds of soybean variety XB50F08, to the plants of soybean XB50F08 to plant parts of soybean variety XB50F08 and to methods for producing a soybean plant produced by crossing plants of the soybean variety XB50F08 with another soybean plant, using XB50F08 as either the male or the female parent.
US08536411B2 Inbred squash line KAZA121
A novel squash inbred line, designated KAZA121, is disclosed. The invention relates to the seeds of squash inbred line KAZA121, to the plants of squash inbred line KAZA121 and to methods for producing a squash plant by crossing the squash inbred line KAZA121 with itself or another squash line. The invention further relates to methods for producing a squash plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other squash lines derived from the squash inbred line KAZA121.
US08536410B2 Red sky, valentine, red morning, and sun rise lettuce varieties
New lettuce varieties designated Red Sky, Valentine, Red Morning, and Sun Rise are described. Red Sky, Valentine, Red Morning, and Sun Rise are Red Leaf lettuce varieties exhibiting stability and uniformity.
US08536407B2 Heat resistant plants and plant tissues comprising a variant adenosine diphosphate glucose pyrophosphorylase small subunit protein and methods of use thereof
The subject invention concerns materials and methods for providing plants or plant tissue with increased resistance to heat conditions and/or increased starch biosynthesis. Increased resistance of a plant or plant tissue to heat conditions provides for decreased yield losses as compared to the yield losses generally observed at elevated temperatures. One aspect of the invention concerns polynucleotides that encode a mutant plant small subunit of AGPase. The subject invention also comprises a mutant plant small subunit of AGPase encoded by a polynucleotide of the invention. The subject invention also concerns plants comprising a polynucleotide of the invention and method for making the plants.
US08536406B2 COMT1 gene fiber-specific promoter elements from poplar
Polynucleotide constructs contain fiber-specific elements which are used to target expression of polynucleotides and polypeptides to the vascular fibers of a plant. The constructs can be contained within a vector. Transgenic plants transformed with the fiber-specific elements can be made which have expression of a polynucleotide or polypeptide directed to the plant fibers.
US08536405B2 Down-regulation of gene expression using artificial MicroRNAs
Isolated nucleic acid fragments comprising precursor miRNA, and artificial miRNAs and their use in down-regulating gene expression are described.
US08536402B2 Plants and seeds of hybrid corn variety CH469284
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH469284. The invention thus relates to the plants, seeds and tissue cultures of the variety CH469284, and to methods for producing a corn plant produced by crossing a corn plant of variety CH469284 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH469284.
US08536401B2 Feminine hygiene article with printed pattern and embossed pattern
A feminine hygiene article such as pantiliner having a topsheet and a backsheet. The article further includes a printed pattern and an embossed pattern. The embossed pattern has at least one embossed decorative element and the printed pattern has a printed decorative element which is substantially similar to the embossed decorative element.
US08536398B2 Method for purifying supply flows containing aromates by means of zeolites
Processes suitable for purifying aromatic-containing feed streams, and processes using such purified streams are described, wherein the purification processes comprise: (a) providing a process feedstream comprising an aromatic component; and (b) bringing the process feedstream into contact with a first zeolite and a second zeolite; wherein the first zeolite has a mean pore size of 0.3 to 0.5 nm, and wherein the second zeolite has a mean pore size of 0.6 to 0.8 nm.
US08536397B2 Recovery of benzene and benzene derivatives from gasoline fraction and refinery streams
A process for the separation of the aromatic compounds benzene, toluene and xylene from an aromatics-containing reformate gasoline and pyrolysis gasoline or a coke-oven light oil or an aromatics-containing refinery stream, in which the aromatics are separated by an extractive distillation uses a novel solvent combination made up of the compounds n,n′-diformyl piperazine or 2,2′-bis-(cyanoethyl)ether in a combination with n-formyl morpholine as a second solvent for extractive distillation so that the solvent combination obtained shows a higher selectivity with regard to the aromatics to be extracted so that a lower solvent load is required. The aromatics-containing feed mixture is first submitted to a pre-distillation so that the obtained fraction has a narrow boiling point range. This fraction is then submitted to an extractive distillation in a first column, in which an aromatics-lean head product of predominantly paraffinic hydrocarbons is obtained as well as an aromatics-enriched bottom product. The bottom product is passed to a second column in which an aromatics-rich raffinate is obtained by reducing the pressure or increasing the temperature so that the extracting solvent combination obtained as bottom product can be recycled into the process.
US08536386B2 Process for the preparation of fluoroolefin compounds
A subject-matter of the invention is a process for the preparation of fluoroolefin compounds. It relates more particularly to a process for the manufacture of a compound of formula (I) CF3—CF═CHX in which X represents a hydrogen or fluorine atom, comprising at least one stage of dehydrofluorination of a compound of formula (II) CF3—CHF—CHFX during which the compound of formula (II) is brought into contact with a mixture composed of water and of potassium hydroxide in which the potassium hydroxide is present in an amount of between 58 and 86% by weight.
US08536383B1 Rhodium/tin catalysts and processes for producing ethanol
The present invention relates to processes for producing ethanol using a catalyst comprising rhodium and tin on a support. The rhodium and tin may be present in a molar ratio of 20:80 to 80:20.
US08536382B2 Processes for hydrogenating alkanoic acids using catalyst comprising tungsten
A process hydrogenating alkanoic acids in the presence of a catalyst that comprises supports, one or more metals, tungsten oxide, and at least one alkaline earth metal oxide or metasilicate. The molar ratio of the at least one alkaline earth metal oxide or metasilicate to tungsten oxide, based on the metals, is from 1:3 to 5:1.
US08536375B2 Synthesis of obtaining modified polyethylene glycol intermediates
The present invention provides novel and more efficient synthesis's for obtaining an intermediate in the synthesis of obtaining a protecting group aminoxy PEG linker.
US08536373B2 Method of production of 9-cis-retinoic acid
Improved method of production of 9-(Z)-retinoic acid, in which a) a β-formyl-crotonic acid C1-C10 alkyl or phenyl ester is reacted with an isolated 9-(Z)—C15-triarylphosphonium salt by the Wittig reaction in the presence of a base to the corresponding 9-(Z)-retinoic acid ester; which b) is then saponified with a base to the corresponding 9-(Z)-retinoic acid carboxylate and then, following protonation with an acid, the desired 9-(Z)-retinoic acid is obtained, and improved method for the enrichment and isolation of the 9-(Z)—C15-triarylphosphonium salt.
US08536366B2 Formation of nitrate esters in microreactors and millireactors using a continuous product extraction in a turbulent flow regime
A process for the continuous production of a compound of Formula (II), HO—R1—ONO2 (II) wherein R1 is a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formula (I), HO—R1—OH (I) wherein R1 is as defined above, with nitric acid in the presence of a first solvent, wherein the compound of Formula (II) is continuously extracted into a second solvent, and the reaction is carried out in a mixing microreactor which provides a power loss of at least 1.3 times the power loss provided under identical conditions by a circular cross-section straight-channel microreactor having an internal diameter equal to the average hydraulic diameter of the mixing microreactor and a length equal to the length of the mixing microreactor.
US08536363B2 Compounds and methods for delivery of prostacyclin analogs
This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have the following formula:
US08536361B2 1,4,6,10-tetra-double bond pentadec-carbon phosphonate, preparation method thereof, and preparation method of lycopene using the same
1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4), and preparation method thereof are provided. The preparation method comprises: reacting a pseudo ionone of formula (2) with sulfonium salt to prepare a epoxide of formula (9), and then reacting the epoxide of formula (9) with magnesium bromide to prepare a C-14 aldehyde of formula (3); condensing the C-14 aldehyde of formula (3) with tetra-alkyl methylene diphosphonate to obtain 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4). Furthermore, the preparation method of lycopene via 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4) is also provided. The present method has the advantages of short route, easily obtained raw materials, and low cost.
US08536358B2 Scaffold materials-transition metal hydride complexes, intermediates therefor and method for preparing the same
The present invention relates to substances which can be applied to the technical fields of gas storages, polymerization catalysts and optical isomers, their intermediates, and processes for preparing the same, which is characterized in that 1) possible disintegration of structure of the scaffold material (SM) is impeded, and 2) they are prepared by a simple manufacturing system as compared to the substances conventionally suggested in the application field. Specifically, it relates to scaffold material-transition metal hydride complexes comprised of scaffold material (SM) and transition metal hydride (M1H(n-1)) which is chemically bonded to the functional groups formed on the scaffold material, SM-transition metal halide complex and SM-transition metal ligand complex as the precursors, and a process for preparing the same. The SM-transition metal hydride complex according to the present invention is a substance for hydrogen storage which adsorbs hydrogen via Kubas adsorption. The complex according to the invention can store high capacity of hydrogen with safety and reversibility, while disintegration of its structure does not occur even with repeated adsorption-desorption of hydrogen.
US08536356B2 Process for preparing crystals based on a fatty acid ester
The present invention relates to an improved process for preparing a fluid concentrated ingredient based on crystals based on a fatty acid ester, and also to the use of this fluid concentrated ingredient.
US08536353B2 Process for the production of an olefin oxide, a 1,2-diol, a 1,2-diol ether, a 1,2-carbonate, or an alkanolamine
A process for the epoxidation of an olefin comprising contacting a reactor feed comprising an olefin, oxygen, and carbon dioxide, with a catalyst comprising a carrier and, deposited on the carrier, silver, a rhenium promoter, a first co-promoter, and a second co-promoter; wherein the carbon dioxide is present in the reactor feed in a quantity of at most 3 mole percent based on the total epoxidation reactor feed; the first co-promoter is selected from sulfur, phosphorus, boron, and mixtures thereof; and the second co-promoter is selected from tungsten, molybdenum, chromium, and mixtures thereof; a process for preparing a 1,2-diol, a 1,2-diol ether, a 1,2-carbonate, or an alkanolamine.
US08536352B2 Method of producing epoxy compounds
Provided is a method of efficiently producing an epoxy compound from an allyl ether having an aromatic ring under mild conditions by using hydrogen peroxide as an oxidizing agent without using an organic solvent. The method of producing an epoxy compound comprises reacting an allyl ether having an aromatic ring with hydrogen peroxide to epoxidize a carbon-carbon double bond of an allyl group to thereby produce a corresponding epoxy compound having an aromatic ring, wherein water only is used as a solvent without using an organic solvent, and a tungsten compound, and a tertiary amine and/or a quaternary ammonium salt, are used as a reaction catalyst.
US08536350B2 Process for the manufacture of dronedarone
The invention relates to a new process for the preparation of dronedarone and its salts, in particular a synthesis process which allows said compound and its salts to be obtained with good yields, high purity and in an industrially expedient manner; the invention also concerns a new synthesis intermediate.
US08536349B2 Cyclic ethers
A process of preparing cyclic ethers is described. The process involves the reaction of at least one organic compound such as a dioi or a polyol which it has at least one pair of hydroxyl groups separated by 4 or 5 carbon atoms, and which is capable of being converted into an ether linkage, with an organic carbonate in the presence of a base. The base is an alkoxy, a carbonate or a hydroxide base or is a mixture of such bases. At least one of the hydroxyl groups of the organic compound is not a tertiary hydroxyl group.
US08536348B2 Lactone formulations and method of use
Compounds of Formulae Ia wherein R1-R9 taken independently are preferably a hydrogen atom, a halogen atom, a hydroxyl group, or any other organic groups or grouping, Z and X are independently and preferably a heteroatom such as oxygen, sulfur, or nitrogen groupings are useful for treatment of bacterial and fungal infections.
US08536337B2 Solid forms of methyl (7aS,2′S)-2-(2-chlorophenyl)-2-(2,4,5,6,7,7a-hexahydrothieno[3,2-c]-5-pyridin-2-one)acetate
New compounds, namely, (7aS,2′S)-2-oxoclopidogrel and its pharmaceutically acceptable salts thereof are disclosed for treatment or prophylaxis of thrombo-embolism and/or cardiovascular diseases.
US08536334B2 Method for producing 3,7-diaza-bicyclo[3.3.1]nonane metal complexes
The invention relates to a method for producing 3,7-diaza-bicyclo[3.3.1]nonane metal complexes, wherein the ligand, a 3,7-diaza-bicyclo[3.3.1]nonane compound, is reacted with an aqueous metal(II)salt solution in one step. According to the invention, the reaction stage is carried out with water as solvent.
US08536333B2 Neutral metallic dendrimer complexes
A charge-neutral organometallic dendrimer is described, said dendrimer having the formula (I): CORE-[DENDRITE(-Q)a]n  (I) in which CORE represents a group of formula MXxYz, in which M represents a metal cation, x represents an integer of 1 or more, each X which may be the same or different represents a mono-, bi- or tri-dentate coordinating group, z represents 0 or an integer of 1 or more, and each Y which may be the same or different represents a coordinating group, the total of (b.x)+(c.z) being equal to the number of coordination sites on M, wherein b is the number of coordination sites on X and c is the number of coordination sites on Y; n represents an integer of 2 or more; each DENDRITE which may be the same or different represents a dendritic molecular structure bonded to a group X; a represents 0 or an integer of 1 or more; and each Q which may be the same or different represents a surface group; CORE terminating in the first single bond which is connected to a branching group or branching atom of DENDRITE; which dendrimer has a structure in which no hemisphere of a notional sphere centered on M and containing the dendrimer is devoid of a said first single bond.
US08536328B2 Process for synthesizing oxidized lactam compounds
The invention provides a method for the synthesis of dehydrogenated lactam drugs of Formula I:
US08536326B2 Method for preparing sucralose with high yield
A method for preparing sucralose with high yield, comprising the following preparation steps: First, negative effects of other impurities on reaction are reduced by first preparing a pure Vilsmeier chlorinating reagent. Second, side reactions are prevented by adding composite catalyst to increase selectivity of chlorination reaction. Third, by extracting less polar impurities using less polar solvent when sucralose-6-ester is undergoing deesterification, products are qualified at the very first time so that refining steps are avoided. Accordingly, product loss is reduced and product yield is increased. By using the present invention to prepare sucralose, product yield could be increased to more than 40%.
US08536325B2 Process for purifying guar
The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.
US08536321B2 Compositions, methods, and kits for the detection of Chlamydia trachomatis
Method for the detection of Chlamydia trachomatis, which method comprises the performance of a DNA amplification involving the use of a primer pair by using DNA that is derived from a sample as a template and the detection of an amplification product, characterized in that the primer pair used for the DNA amplification is designed on the basis of nucleotide sequences of the regions corresponding to the nucleotide numbers 3654 to 4320 and 4351 to 4448 in the nucleotide sequence of SEQ ID No. 1.
US08536318B2 Chemical RNA synthesis method
The invention relates to a method for the chemical synthesis of RNA, comprising the following steps: a) bonding to a solid support of a monomer having formula (II) in which—X1 is a dimethoxytrityl group,—X6 is H or an OAc group or OX3, in which X3 is a group having formula (A), in which X is O or S, R′ is H or CH3 and R is selected from a linear or branched alkyl group at C1 to C4 and a R1—O—R2 group in which R1 is an alkyl group at C1 to C2 and R2 is a CH3 group or CH2CH2—O—CH3 or aryl; b) assembly with the monomer having formula (II) bound to the support thereof obtained in step (a) of at least one monomer having formula (III) in which X1, Bp, X3 are as defined for formula (II) and X5 is a hydrogen phosphonate monoester or phosphoramidite group, preferably a 2-cyanoethyl-N,N-diisopropylphosphoramidite group, which is used to obtain a protected single-strand RNA bound to a support.
US08536317B2 Crosslinked polysaccharide sponge
A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtaining the polysaccharide sponge. The process includes simplified steps requiring no removal of solvent, and has such an advantage that impurities are easily removed therefrom.
US08536316B2 Methods for purifying a target protein from one or more impurities in a sample
The present invention relates, at least in part, to improved methods of protein purification. In particular, the present invention relates, at least in part, to methods for purifying an Fc region containing protein from a composition comprising the Fc region containing protein and one or more impurities, where the methods eliminate the need for a holding tank and/or a buffer exchange step.
US08536315B2 Production and purification of recombinant arylsulftase
The present invention pertains to a process for production of recombinant arylsulfatase A in a cell culture system, the process comprising culturing a mammalian cell capable of producing rASA in liquid medium in a system comprising one or more bio-reactors; and concentrating, purifying and formulating the rASA by a purification process comprising one or more steps of chromatography. Other aspects of the invention provides a pharmaceutical composition comprising rASA, which is efficiently endocytosed via the mannose-6-phosphate receptor pathway in vivo as well as a rhASA a medicament and use of a rhASA for the manufacture of a medicament for reducing the galactosyl sulphatide levels within target cells in the peripheral nervous system and/or within the central nervous system in a subject. A final aspect of the invention provides a method of treating a subject in need thereof, said method comprising administering to said subject a pharmaceutical composition comprising a rhASA and thereby obtaining a reduction in the galactosyl sulphatide levels in target cells within said subject.
US08536313B2 Monoclonal antibody having neutralizing activity against MMP13
A neutralizing monoclonal antibody specifically reacting with MMP13, a method of neutralizing enzyme activity of MMP13 and an immunological measuring method each using the antibody, as well as a diagnostic agent and a pharmaceutical composition containing the antibody, are provided. Various antibodies to MMP13 have been hitherto obtained, but an antibody having neutralizing activity against MMP13 has not been obtained. The present inventors intensively studied, as a result, found out a neutralizing antibody having specificity for MMP13, resulting in completion of the present invention.
US08536312B2 Monoclonal antibodies with specificity for fetal erythroid cells
The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The inventive monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.
US08536306B2 Human A2A adenosine receptor crystals and uses thereof
The invention provides the structure of human A2A adenosine receptor protein bound to an antagonist. Methods of using one or more binding sites and other features of this G-protein coupled receptor to develop new therapeutics are also disclosed.
US08536305B2 Processes for preparing a polypeptide
The present invention relates to an improved process for preparing a polypeptide or pharmaceutically acceptable salt thereof comprising L-tyrosine, L-alanine, L-glutamate, and L-lysine. The polypeptide or pharmaceutically acceptable salt thereof is preferably glatiramer acetate. The process comprises: (a) polymerizing a mixture of N-carboxyanhydride of L-tyrosine, N-carboxyanhydride of L-alanine, N-carboxyanhydride of a protected L-glutamate and N-carboxyanhydride of a protected L-lysine, in a polar aprotic solvent in the presence of an initiator, to form a protected polypeptide; (b) admixing an acid with the protected polypeptide formed in Step (a) and a solvent, to form a product; and (c) admixing a substance selected from the group consisting of an alkali or alkaline earth metal hydroxide, a carbonate, a hydrogencarbonate, and mixtures thereof, with the product formed in Step (b), and a solvent or a mixture of a solvent and water, to form a deprotected polypeptide or a pharmaceutically acceptable salt thereof.
US08536303B2 Polypeptide inhibitors of HSP27 kinase and uses therefor
The present invention provides polypeptide inhibitors of HSP27 kinase, compositions thereof, and methods for using such polypeptides and compositions for various therapeutic uses.
US08536300B2 Photocrosslinkable electrically conductive polymers
Photocrosslinkable electrically conductive polymers and compositions including the polymers are provided. Also, electrically conductive layers or films formed from the compositions, preparation methods of these, and articles including the electrically conductive layers or films are provided. The electrically conductive polymers according to the present disclosure have photoreactive groups that can be crosslinked using like. The electrically conductive polymers can also be dissolved in aqueous solution. These photocrosslinkable and soluble properties allow the electrically conductive polymers to be used in wet processing to make films and/or to be made into a patterned conductive layer or film using a photomask.
US08536299B2 Rigid-rod copolymer compositions and the polymeric fibers fabricated from those compositions for enhanced flame resistance
Rigid-rod copolymer compositions incorporating PBO (poly(p-phenylenebenzobisoxazole)), DiOH-PBO (poly(2,5-dihydroxy-1,4-phenylenebenzobisoxazole), DiOH-PBI (poly(2,5-dihydroxy-1,4-phenylenebenzobisimidazole)), DiOH-PyBI (poly(2,5-dihydroxy-1,4-phenylenepyridobisimidazole), PBZT (poly(p-phenylenebenzobisthiazole)) and its corresponding dihydroxy analogues attached to a flexibilizing hexafluoroisopropylidene linkage are described. Also described are their fabrication into fibers by a dry jet wet spinning technique and the measured fiber mechanical properties. The copolymer compositions are highly flame-resistant and have potential utility for fire-protective clothing.
US08536298B2 Precipitative process to prepare polyimides
A process for preparing polyimide resins comprises stirring a diamine and a dianhydride in a solvent to form a slurry; heating the slurry to a temperature sufficient for the diamine and dianhydride to react wherein the temperature is below the melting point of the dianhydride, below the melting point of the diamine, or below the melting points of the dianhydride and diamine; and reacting the diamine and dianhydride to form a polyimide having sufficient molecular weight to precipitate from the solvent.
US08536295B2 Method of imparting corrosion resistance to a substrate surface, and coated substrates prepared thereby
The disclosure provides methods and materials for imparting corrosion resistance to a substrate, as well as the corrosion-resistant substrates prepared accordingly. Compositions and methods include nonpyrolyzed, silicon-based polymer coatings prepared on substrates. The prepared coatings are highly stable and resistant to corrosion. The invention finds utility, for example, in the fields of surface and coating chemistry.The composition contains silicon-containing polymers having units of the following formulae: [R1Si(OH)O]k  (III) [R1Si(OR10)O]m  (IV) [R1SiO1.5]n  (V) [R1Si(H)O]p  (VI) [R2R3SiO]q  (VII).
US08536291B2 Hydrogel compositions and methods of preparation thereof
Block copolymers include hydrophobic and hydrophilic blocks having repeating units derived from ring opening polymerization of one or more cyclic carbonate monomers. The carbonate monomers are independently selected from compounds of formula (II): wherein each Q′ and Qa group independently represents a hydrogen, an alkyl group, a halide, a carboxy group, an ester group, an amide group, an aryl group, an alkoxy group, or a foregoing Q′ or Qa group substituted with a carboxy group or an ester group, at least one Q′ and Qa group includes an ester group; each Y independently represents O, S, NH, or NQ″; n is an integer from 0 to 6, wherein when n is 0, carbons labeled 4 and 6 are linked together by a single bond; each Q″ group independently represents an alkyl group, an aryl group, or a foregoing Q″ group substituted with a carboxy group, or an ester group.
US08536290B2 Procatalyst composition with alkoxyalkyl 2-propenoate internal electron donor and polymer from same
Disclosed herein are catalyst compositions and polymers, i.e., propylene-based polymers, produced therefrom. The present catalyst compositions contain an internal electron donor of an alkoxyalkyl 2-propenoate and optionally a mixed external electron donor. The present catalyst compositions improve catalyst selectivity and polymer stiffness. Polypropylene homopolymer produced from the present catalyst composition has a xylene solubles content less than 4 wt % and a TMF greater than 172.0° C.
US08536283B2 Varnish composition with high glass transition temperature for glass fiber laminate
A varnish composition includes (1) a benzoxazine resin having highly symmetric molecular structure; (2) at least one of naphthol novolac resins, aniline novolac resins and phenolic novolac resins; (3) fillers. The benzoxazine resin having highly symmetric molecular structure, and the at least one of naphthol novolac resins, aniline novolac resins and phenolic novolac resins contribute to increase the glass transition temperature of the varnish composition, while decrease the coefficient of thermal expansion and moisture absorbability due to their small and highly symmetric molecular structures. A copper substrate can meet the requirement of high glass transition temperature (TMA≧200° C.) and low coefficient of thermal expansion (α1/α≦30/135 (μm/m° C.). Therefore, the composition of the invention can be widely used as high-performance electronic material.
US08536282B2 Silylated polycarbonate polymers, method of making, and articles
A polycarbonate polymer or copolymer comprising pendant silylated dihydroxy aromatic compound of the formula (1a); wherein Ga and Gb are each independently C1-12 alkyl, —OSi(C1-12 alkyl)3, C1-12 arylalkyl, or —OSi(C1-12 arylalkyl)3; Za and Zb are each independently a straight or branched C2-18 is alkylene, a C8-18 arylalkylene, or a C8-18 alkylarylene, Xa is a direct bond, a heteroatom-containing group, or a C1-18 organic group, and r and s are each independently 1 or 2 is disclosed.
US08536278B2 Method for the surface post-crosslinking of water absorbing polymer particles
A process for producing water-absorbing polymer particles, wherein the water-absorbing polymer particles are surface postcrosslinked with unsaturated fatty acids or derivatives thereof.
US08536273B2 Toughened composition
The instant invention relates to epoxy resin compositions comprising an epoxy resin, a block copolymer having at least one block predominantly composed of methyl methacrylate units or a core shell component and a hardener of the polyoxyalkyleneamine type. The epoxy materials cured from these compositions have high impact resistance.
US08536270B2 Resist composition, resist layer, imprinting method, pattern formation, method for producing magnetic recording medium, and magnetic recording medium
To provide a resist composition including: at least one polymerizable compound having a viscosity of 100 mPa·s or less at 25° C.; a fluorine-containing compound A having a viscosity of 5,000 mPa·s or greater at 25° C., and a fluorine content of 10% by mass or greater; and a fluorine-containing compound B having a viscosity of 2,000 mPa·s or less at 25° C., and a fluorine content of 10% by mass or greater.
US08536268B2 Polypropylene-based adhesive compositions
An adhesive composition comprising a copolymer of propylene and at least one comonomer selected from the group consisting of ethylene and C4-20α-olefins, the copolymer having (i) a content of units derived from propylene of greater than about 50 mole percent, (ii) a Brookfield viscosity at 190 C from about 50 to about 100,000 cP, (iii) an MWD from about 1.5 to about 15, and (iv) containing less than about 50 ppm residual catalyst metal.
US08536266B2 Pneumatic tire
A pneumatic tire having a tread, the tread comprising a rubber composition comprising: a copolymer comprising a polymeric backbone chain derived from a monomer comprising at least one conjugated diene monomer and optionally at least one vinyl aromatic monomer; and polymeric sidechains bonded to the backbone chain, the sidechains comprising a polymer capable of exhibiting a lower critical solution temperature (LCST); optionally, at least one additional diene based elastomer; and a filler selected from the group consisting of carbon black and silica.
US08536265B2 Polymeric material
A polyaryletherketone polymeric material, for example polyetheretherketone and composite materials comprising said polymeric material are described. The polymeric material has a melt viscosity (MV) in the range 0.05 to 0.12 kNsm−2, preferably in the range 0.085 to 0.095 kNsm−2.
US08536264B2 Pneumatic tire and rubber composition containing twin polymerization structures
The present invention is directed to a pneumatic tire comprising a component, the component comprising a rubber composition comprising a diene based elastomer and 1 to 100 phr of: A) a twin polymerization reaction product of a silyl ether; or B) a twin polymerization reaction product of a boronic acid ester; or C) a twin polymerization reaction product of a titanium compound derived from tetraethyl orthotitanate and furfuryl alcohol; or D) a twin polymerization reaction product of a tungsten compound; The invention is further directed to the corresponding rubber compositions.
US08536261B2 Rubber composition containing treated silica and products with component thereof
The invention relates to rubber compositions containing a treated silica, particularly sulfur cured rubber compositions, and articles of manufacture having a component thereof such as, for example tires. The invention particularly relates to synthetic amorphous silica, particularly a precipitated silica, treated with a combination of allylsilane and dialkylsilane.
US08536259B2 Formaldehyde free coatings for panels
The invention, provides a curable, formaldehyde free coating composition comprising a composition comprising a polyacid copolymer crosslinked with a hydroxyl group-containing compound and calcium aluminosilicate powder, panels coated with the coating composition, and a method of coating a panel with the coating composition.
US08536258B2 Stabilizer and method of manufacturing the same, thermoplastic polymer composition using the same, and method of stabilizing thermoplastic polymer
The present invention provides a stabilizer containing, as a main component, a bisphenol monoester and a bisphenol-based compound, wherein the area of the bisphenol-based compound is 0.15 to 70 when the area of the bisphenol monoester is set to be 100 in a chromatograph obtained by liquid chromatography analysis of the stabilizer, a method of manufacturing the same, a thermoplastic polymer composition containing the stabilizer, as well as a stabilizer that can further improve the process stability of the thermoplastic polymer, as compared with the conventional one, by compounding the stabilizer into the thermoplastic polymer through a method of stabilizing the thermoplastic polymer using the stabilizer and a method of manufacturing the stabilizer.
US08536256B2 DOPO-derived flame retardant and epoxy resin composition
This invention relates to 9,10-Dihydro-9-Oxa-10-Phosphaphenantrene-10-oxide derived additive flame-retardants, which are useful in epoxy resin compositions. The epoxy resin compositions may be used in making prepregs or laminates for printed wiring boards and composite materials.
US08536255B2 Stable emulsions for producing polymer modified asphalt
An acid modified asphalt binder is combined with an emulsifier solution to produce an emulsified asphalt binder. The acid modified asphalt binder may be formed by combining an asphalt binder, a phosphorous-based acid, and, optionally, a polymer modifier. The emulsifier solution may be produced by forming an aqueous solution of an amine and a phosphorous-based acid, which forms an aqueous solution comprising an amine phosphate. The emulsified asphalt binder may be combined with an aggregate to form a paving material. In other examples, the emulsified asphalt binder may be used alone, for example in a chip seal application, or in a diluted form, for example in a fog seal application.
US08536254B2 Curable casting compound containing keratin fibers and plastic moulded parts produced therefrom
In order to provide a curable casting compound for producing plastic molded parts, comprising a binder component based on polymerizable monomers selected from methyl acrylate or methyl methacrylate and a proportion of about 40 to about 85% by weight of one or more inorganic fillers, which compound can be used for producing plastic molded parts having an increased impact strength, it is proposed that the casting compound comprise 0.1 to 0.5% by weight of keratin fibers.
US08536247B2 Polyamide resistant to heat aging
Thermoplastic molding compositions, comprising A) from 10 to 99.999% by weight of a polyimide B) from 0.001 to 20% by weight of iron powder with a particle size of at most 10 μm (d50 value), which is obtainable via thermal decomposition of pentacarbonyliron, C) from 0 to 70% by weight of further additives, where the total of the percentages by weight of components A) to C) is 100%.
US08536246B2 Ink composition, ink set and image forming method
The present invention provides an inkjet ink composition including color material particles, a water soluble polymerizable compound, a water soluble silicate salt and water, which is excellent in ejection stability even in a case in which the ink composition is stopped from ejecting in the inkjet recording device and left alone for a certain period of time, and ejection of the ink composition is resumed thereafter, which has a good maintenance property, and in which abrasion resistance of images formed with the ink composition is excellent; an ink set including the inkjet ink composition; and an image forming method using the ink set.
US08536244B2 Friction lining mixture for a friction material, in particular for brake and clutch linings
The friction lining mixture for a friction material for brake and clutch linings, the brake and clutch linings contains metal fibers and/or powder, functional fillers, lubricants and organic compounds for improving the performance capability of the friction pairing metallic and/or alloyed and/or bound tin in an amount of 0.5 to 50.0 percent by weight, preferably 2.0 to 10.0 percent by weight, the copper content in the friction lining mixture being 0.001 to 4.999 percent by weight, preferably 0.001 to 0.499 percent by weight.
US08536241B2 (Meth)acryloyl pressure-sensitive foam adhesives
This disclosure provides (meth)acryloyl pressure-sensitive adhesive foams and foam articles having one or more of the following properties: small cells, uniform cell sizes, pressure sensitive adhesive compositions, compliance to irregular substrates and vibration damping, and shock absorbing properties.
US08536240B2 Expandable polystyrene composition
An expandable polystyrene composition in the form of expandable beads, comprising by weight (1) 100 parts of a styrene polymer, (2) from 2.2 to less than 4.0 parts of at least one blowing agent, and (3) from 0.01 to 0.4 part of at least one plasticizing. The composition is particularly useful for manufacturing medium density expanded moulded polystyrene objects, particularly with a density from 40 to 190 g/l. A process for manufacturing such objects,is provided, together with pre-expanded beads with a buld density of 40 to 190 g/l, containing by weight (a) 100 parts of a styrene polymer, (b) from 0.5 to less than 3.0 parts of at least one blowing agent, and (c) from 0 to 0.4 part of at least one plasticizing agent.
US08536235B2 Methanol process
A process for the synthesis of methanol comprises: (a) passing a synthesis gas mixture comprising a loop gas and a make-up gas through a first synthesis reactor containing a methanol synthesis catalyst, said reactor cooled by boiling water under pressure, to form a mixed gas containing methanol, (b) cooling the mixed gas containing methanol, (c) passing said cooled mixed gas containing methanol through a second synthesis reactor containing a methanol synthesis catalyst in which further methanol is synthesized to form a product gas stream, (d) cooling said product gas to condense methanol, (e) recovering said methanol and returning unreacted gas as the loop gas to said first synthesis reactor, wherein the mixed gas containing methanol from the first synthesis reactor is cooled in heat exchange with either said loop gas or said make up gas.
US08536234B2 Process for generation of synthetic fuel from carbonaceus substances
A method and apparatus for the generation of synthetic motor fuels and additives to oil fuels, C1-C4 alcohols, hydrogen, methane, synthesized gas (H2+CO2) by hydrothermal treatment of carbonaceous compounds by providing a two-stage carbon gasification process operated under the supercritical conditions of H2O and CO2, including a first stage gasification reactor having a reaction zone for the conversion of carbonaceous compounds and a second stage reactor for the conversion of the products of the first stage reactor; feeding a aqueous suspension of carbonaceous compound in an amount of at least 30% by weight and an alkali metal or alkaline-earth metal catalyst or reactive OH-species from an electrolyzer through said first stage gasification reactor as a supercritical fluid at a volume velocity of 0.01-0.05 g of carbon per 1 cm3 per hour, at a carbon/catalyst mole ratio of between about 70/1 and 90/1, at a temperature of 390-450° C., and under a pressure of about 225 to 500 bars; feeding the reaction products from the first stage reactor to the second stage reactor over a copper-zinc catalyst at the temperature of 200-280° C. and under a pressure of at least about 100 bars so that any gases generated in the first stage are converted into C1-C4 alcohols with the weight ratio of C1-C2 to C3-C4 between about 0-35% to 100-65%.
US08536233B2 Method of producing synthetic gas with partial oxidation and steam reforming
Process for producing liquid hydrocarbons from a heavy feedstock such as biomass, carbon, lignite, or heavy petroleum residue comprising:A partial oxidation b) of the heavy feedstock, producing a synthesis gas SG1, with an H2/CO ratio<1; A steam reforming c) of a light feedstock that comprises hydrocarbons having at most 4 carbon atoms, for the production of a synthesis gas SG2 with an H2/CO ratio>3; A Fischer-Tropsch conversion into liquid hydrocarbons of a synthesis gas SG, mixture of at least a portion of SG1 and at least a portion of SG2, in proportions such that SG has an H2/CO ratio of between 1.2 and 2.5. The light feedstock comprises hydrocarbons having less than 10 carbon atoms C1-C10 are obtained from a pretreatment of the heavy feedstock and/or are produced in the Fischer-Tropsch stage and/or during a downstream hydrocracking stage.
US08536230B2 Methods for regulating gelation of polysaccharide solutions and uses thereof
The present invention provides a method for preparing chitosan solutions to allow regulating the conditions in which the chitosan solution will gel. The present invention also provides methods for using chitosan solutions as compositions and for using chitosan solutions in vitro and in vivo.
US08536227B2 Modulators of protein kinase signaling
The present invention provides new tyrphostin derivatives acting as protein kinase (PK) and receptor kinase (RK) signaling modulators. The invention further provides methods of their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for preventions and treatments of PK and RK related disorders such as metabolic, inflammatory, fibrotic, and cell proliferative disorders, in particular cancer.
US08536222B2 Addition compounds of guanidinoacetic acid
The present invention provides new addition compounds of guanidinoacetic acid with malic acid, aspartic acid, ascorbic acid, succinic acid, pyruvic acid, fumaric acid, gluconic acid, alpha-ketoglutaric acid, pyroglutamic acid, 3-nicotinic acid, lactic acid, citric acid, maleic acid, acetic acid, formic acid, 2-hydroxybenzoic acid, L-carnitine, acetyl-L-carnitine, taurine, betaine, choline, methionine and lipoic acid as well as in the form of sodium, potassium or calcium guanidinoacetate. These addition compounds have improved physiological and therapeutic properties and are particularly suitable for use as dietary supplements, as animal feeds and in cosmetic or dermatological preparations in which especially the marked stability and good bioavailability of the addition compounds come to the fore.
US08536221B2 Amide derivatives as positive allosteric modulators and methods of use thereof
The invention relates to novel amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
US08536218B2 Whitening agents for cellulosic substrates
This invention relates to novel whitening agents for cellulosic substrates. The whitening agents are comprised of at least two components: at least one chromophore component and at least one polymeric component. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to ultraviolet light, or they may absorb light to reflect these same shades. The whitening agents are further characterized by having a dispersion component value of the Hansen Solubility Parameter of less than or equal to about 17 MPa0.5. This invention also relates to laundry care compositions including but not limited to liquid and/or powder laundry detergent formulations and rinse added fabric softening (RAFS) compositions that comprise such whitening agents.
US08536216B2 Compositions based on aminoacids
Compositions based on amino acids are described, in particular for oral or parenteral use, suitable for treating heart insufficiency. The compositions according to the invention comprise up to 75% of the branched chain amino acids leucine, isoleucine and valine, as active ingredients. Preferably, the compositions also comprise, as further active ingredients, up to 50% of theronine and lysine. Other essential amino acids are preferably also provided (in particular methionine, phenylalanine, histidine, triphtophan) as well as non essential amino acids (in particular tyrosine and/or cyst(e)ine—i.e., cystine and cyst(e)ine). Other amino acids can be added, provided that their sum is in a percentage being lower than 20% with respect to the other active ingredients, and less than 10% for each single amino acid.
US08536212B2 Protective agent for retinal nerve or optic nerve
The present invention provides a protective agent for retinal nerve or optic nerve which exerts its effect through a different mechanism from that of conventional therapeutic agents and can be taken for long periods. The present invention is the protective agent for retinal nerve or optic nerve which comprises a compound with aldose reductase inhibiting activity such as the compound represented by the following general formula as an active ingredient. A preferable compound thereof is (2S,4S)-6-fluoro-2′,5′-dioxospiro[chroman-4,4′-imidazolidine]-2-carboxamide: wherein X represents a halogen atom or a hydrogen atom, R1 and R2 independently represent a hydrogen atom or an optionally substituted C1 to C6 alkyl group, or R1 and R2, together with a nitrogen atom bound thereto, or optionally another nitrogen atom or an oxygen atom, are combined to form a 5- to 6-membered heterocycle.
US08536209B2 Aminotriazole derivatives as ALX agonists
The invention relates to aminotriazole derivatives of formula (I), wherein A, E, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.
US08536204B2 Amides and thioamides as pesticides
The present application relates to novel amides and thioamides, to processes for preparation thereof and to use thereof for controlling animal pests, in particular arthropods and especially insects.
US08536202B2 Triazole-substituted anthranilamides as pesticides
The present invention constitutes new, triazole-substituted anthranilamides of the general formula (I), —in which R1, R2, R3, R4, R5, R6, Q, A and n have the definitions indicated in the description—, the application thereof as insecticides and acaricides for controlling animal pests, also in combination with further agents for activity boosting, and a number of processes for their preparation.
US08536193B2 Inhibitors of AKT activity
The instant invention provides for substituted [1,2,4]triazolo[4,3-a]-1,5-naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity, especially Akt1 by administering the compound to a patient in need of treatment of cancer.
US08536189B2 Spiropiperidines for use as tryptase inhibitors
The present invention is directed to a compound of Formula (I): or a form thereof, wherein X1, X2, X3, X4, R1, R2 and R3 are as defined herein, useful as tryptase inhibitors.
US08536185B2 Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases
Multiheteroaryl compounds, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical use in the prevention and treatment of prostaglandin D2 mediated diseases and conditions that may be modulated by the inhibition of hematopoietic prostaglandin D synthase (H-PGDS).
US08536184B2 Nitrogenous heterocyclic compounds and process for making nitrogenous heterocyclic compounds and intermediates thereof
The present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof and a process for making thereof. The compounds have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention also provides intermediate compounds useful in the process, as well as final products produced by the process, and salts or prodrugs thereof. The invention further provides a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases comprising administering an effective amount of a compound according to the invention to a patient in need thereof.
US08536183B2 3-pyridylcarbonyl-piperazinylsulfonyl derivatives
The present invention relates to novel piperazine derivatives; to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial.
US08536182B2 Benzylpiperazine derivatives and their medical use
The present invention relates to novel benzylpiperazine derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.
US08536181B2 Prolyl hydroxylase inhibitors
Disclosed herein are prolyl hydroxylase inhibitors that can stabilize hypoxia inducible factor-1 alpha (HIF-1α), as well as hypoxia inducible factor-2 (HIF-2). Also disclosed herein are pharmaceutical compositions comprising one or more of the disclosed compounds. Yet further disclosed are methods for stimulating the cellular immune response in a mammal such as increasing phagocytosis, for example, prolonging the life of phagocytes, inter alia, kerotyiocytes, neutrophils. As such the disclosed compounds provide methods for treating diseases that relate to the body's immune response.
US08536180B2 Pyrimidine inhibitors of kinase activity
Described herein are compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, L1, R2, R3, n, p, Ar1, and Ar2 are defined in the description. Methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-1R are also disclosed.
US08536175B2 Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors
The invention relates to compounds of formula (I) wherein the substituens are as defined in the specification, in free form or in the form of a pharmaceutically acceptable salt, solvate, ester, N-oxide thereof; processes for the preparation thereof; to pharmaceuticals containing such compounds, in particular for the use in one or more Protein tyrosine kinase mediated diseases.
US08536166B2 Inhibitors of Burton's tyrosine kinase
This application discloses 5-phenyl-1H-pyrazin-2-one derivatives according to generic Formulae I-V: wherein, variables Q, R, Y1, Y2, Y2′, Y3, Y4, n and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of Formulae I-V and at least one carrier, diluent or excipient.
US08536162B2 Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugates
Conjugates of 1,3-bis(1,4,7-triazacyclonon-1-yl)-2-hydroxypropanes with a variety of conjugating members are used in the formation of dinuclear metal complexes which bind to phosphate esters. By virtue of their conjugated forms, the complexes are incorporated into chromatographic media, affinity binding reagents, and dyes, which make the complexes useful in a wide range of assays, separations, and purifications. In addition, dinuclear metal complexes of 1,3-bis(1,4,7-triazacyclonon-1-yl)-2-hydroxypropanes that are not so conjugated are used in the detection of phosphate esters of biological species by either MALDI-TOF mass spectrometry or by dye displacement.
US08536161B2 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents for the treatment of hematopoietic malignancies
Combinations of PI3K inhibitor compounds having Formula I and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for treating hematopoietic malignancies. Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
US08536160B2 Azaheterocyclyl derivatives of androstanes and androstenes as medicaments for cardiovascular disorders
Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
US08536149B2 TRPM-2 antisense therapy
It has now been determined that antisense therapy which reduces the expression of TRPM-2 provides therapeutic benefits in the treatment of cancer. Addition of antisense TRPM-2 ODN to prostatic tumor cells in vivo is effective for delaying the onset of androgen independence. Combined use of antisense TRPM-2 and taxanes synergistically enhances cytotoxic chemosensitivity of androgen-independent prostate cancer. In addition, it has also been found that antisense TRPM-2 has beneficial effect for other cancer types. Specifically, antisense TRPM-2 ODN enhances chemosensitivity in human Renal cell cancer, a normally chemoresistant disease with no active chemotherapeutic agent having an objective response rate higher than 10%. Radiation sensitivity is also enhanced when cells expressing TRPM-2 are treated with antisense TRPM-2 ODN. Thus, the antisense TRPM-2 ODNs can be used to enhance hormone sensitivity, chemosensitivity and radiation sensitivity of a variety of cancer types in which expression of TRPM-2 has been observed.
US08536148B2 Disabling autophagy as a treatment for lysosomal storage diseases
Provided herein are methods of treating lysosomal storage disease, for instance Pompe disease, through inhibition of autophagy. Optionally, treatment is administered as an adjunct to enzyme replacement therapy (ERT).
US08536145B2 Methods of inducing mucosal immunity
Methods of inducing mucosal immunity in individuals against proteins and peptides are disclosed. The methods comprise the step of administering topically or by lavage into mucosal tissue selected from the group consisting of rectal, vaginal, urethral, sublingual and buccal, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein or peptide that comprises an epitope against which mucosal immunity is desired. The methods may be used to immunize and individual against a pathogen infection, hyperproliferative diseases or autoimmune diseases using nucleic acid molecules which encode proteins and peptides that share an epitope with a pathogen antigen or protein associated with cells involved in hyperproliferative diseases or autoimmune diseases, respectively.
US08536144B2 Anti-fungal composition
The present invention relates to an improved anti-fungal composition, to a process for preparing it and to its use as a preservative.
US08536131B2 Synthetic peptide amides and dimers thereof
The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure: The compounds are useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions.
US08536130B2 Use of 1 phenyl-3-dimethylamino-propane compounds for treating neuropathic pain
Use of 1-phenyl-3-dimethylaminopropane compounds for the production of medicaments for treating neuropathic pain, preferably polyneuropathic pain, also preferably diabetic neuropathic pain, more preferably diabetic peripheral neuropathic pain, and furthermore preferably for treating diabetic peripheral neuropathy.
US08536128B2 Granulin/epithelin precursor (GEP), a chondrogenic growth factor and target in cartilage disorders
The present invention relates to the expression and regulating growth factors in chrondrocytes and developing cartilage, particularly granulin-epithelin precursor (GEP). The invention relates to the modulation and manipulation of these growth factors, GEP, and/or the molecules they interact with, for instance COMP, in cartilage disorders, including arthritis. Assays and screening methods for the determination of the expression and activity of GEP, or of GEP-COMP, are provided, including for screening for the presence or extent of cartilage or arthritic disease and for identifying modulators or compounds/agents for treatment or prevention of cartilage or arthritic diseases.
US08536125B2 Stabilization of liquid solutions of recombinant protein for frozen storage
The invention relates to a method for stabilizing a bulk solution of recombinant protein for frozen storage, which comprises providing a partially-purified solution of recombinant protein which has a monovalent salt concentration of at least 100 mM, and adding a carbohydrate to said solution in an amount sufficient that, upon freezing, the solution has a glass transition temperature of −56° C. or higher.
US08536124B2 Artificial decapeptide for inducing vitellogenesis in fish
An artificial decapeptide for inducing vitellogenesis in fish, being an analogue of gonadotropin-releasing hormone of chicken is set forth in SEQ ID NO: 2. The artificial decapeptide can be further developed and manufactured into a preparation, which is capable of inducing vitellogenesis in fish. With the implantation of the preparation into body cavity or body wall of bony fish, the induction of vitellogenesis and ovum maturation in bony fish can be successfully achieved.
US08536120B2 Ghrelin/growth hormone releasing peptide/growth hormone secretatogue receptor antagonists and uses thereof
The present invention provides novel compounds that have been demonstrated to be modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, iso forms and variants thereof). These compounds are useful as antagonists of the ghrelin receptor as well as inverse agonist, partial agonist or a combination of these activities as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, diabetes, central nervous system disorders, genetic disorders, and hyperproliferative disorders.
US08536118B2 Methods and compositions for modulating hyperstabilized c-met
The invention provides methods and compositions for modulating the HGF/c-met signaling pathway, in particular by inhibiting a hyperstabilized c-met protein.
US08536116B2 Antagonists for diseases induced by cells with high-affinity ELR-CXC chemokine receptor proteins
Enclosed is an antagonist, which includes a peptide chain represented by an amino acid sequence. The amino acid sequence has a short sequence, C-X1X2X3X4X5-N, which is situated before and neighbored to the third cysteine (Cys, C) of the N-terminus, wherein X1 is an amino acid with aromatic ring, hydrophobic property or long chain, and X2, X3, X4 and X5 are glutamine (G), serine (S), alanine (A) and proline (P) respectively. In one embodiment, X1 is phenylalanine (F). The present antagonists can be used to inhibit or treat with the diseases caused by the activated cells expressing CXCR1 and/or CXCR2 receptor, for example, the acute or chronic inflammatory reaction induced with polymorphonuclear neutrophils (PMNs) expressing CXCR1 and/or CXCR2 receptor, and angiogenesis accompanied by tumor growth inhibition.
US08536115B2 Compositions and methods for modulating AMPA receptor-mediated excitotoxicity
The present invention provides AMPAR excitotoxicity mediating polypeptides comprising the GluR2 NT1-3-2 (Y142-K172) amino acid sequence (SEQ ID NO:1) or the GAPDH(2-2-1-1) (I221-E250)amino acid sequence (SEQ ID NO:2). Also disclosed are nucleotide sequences encoding the polypeptides, methods of inhibiting GAPDH association with the GluR2 subunit or p53. Methods of inhibiting AMPA receptor mediated excitotoxicity using the polypeptides and nucleic acids are also disclosed.
US08536112B2 Liquid cleaning compositions containing sulfonated estolides and alkyl ester sulfonates
Liquid cleaning compositions are described that comprise sulfo-estolide (SE) salts, particular sodium, lithium or ammonium salts of sulfo-estolides, and alkyl ester sulfonates. The liquid cleaning compositions are clear, stable and substantially free of precipitates due to the use of sodium, lithium or ammonium salts of sulfo-estolide rather than a potassium sulfo-estolide salt in the composition. The liquid cleaning compositions also have a total combined amount of saturated C16 and C18 fatty acids of less than about 5% by weight to prevent the formation of precipitates in the composition.
US08536109B2 Foam control composition
This invention relates to a foam control composition comprising: (A) a silicone antifoam comprising (i) an organopolysiloxane having at least one silicon-bonded substituent of the formula X—Ar, wherein X represents a divalent aliphatic group bonded to silicon through a carbon atom and Ar represents an aromatic group, (ii) an organosilicon resin having the formula R1aSiO(4-a)/2 where R1 represents a hydrocarbon, a hydrocarbonoxy or a hydroxyl group and a has an average value of 0.5 to 2.4, and (iii) a hydrophobic filler; and (B) an organopolysiloxane resin having at least one polyoxyalkylene group in which the organopolysiloxane resin comprises tetrafunctional siloxane units having the formula SiO4/2 and monofunctional siloxane units having the formula R23SiO1/2, wherein the total number of tetrafunctional siloxane units in the resin is at least 50% based on the total number of siloxane units, and R2 represents a hydrocarbon group. The foam control composition may be added to a potentially foaming liquid, particularly a detergent, such as an HDL detergent.
US08536108B2 Care polymers
The present application relates to care polymers and fabric and home care compositions comprising such care polymers, as well as processes for making and using such care polymers and such compositions. The performance of the care polymers that Applicants teach, can be further increased by following the emulsification teaching of the present specification and/or combining such care polymers with silicone materials.
US08536107B2 Glassware corrosion inhibitor
Article for use in a dishwashing machine, which comprises a water-soluble glass or ceramic composition effective to reduce corrosion of glassware and at least one surfactant containing composition, wherein the amount of the glass or ceramic composition is within the range of 5 to 95 wt. % and the amount of the surfactant is in the range of 5 to 95 wt. %, both percentages based on the weight of the article.
US08536105B2 Method of cleaning contaminated surfaces
A medical instrument cleaning concentrate and method for cleaning medical equipment. The concentrate contains an active ingredient consisting essentially of (i) a biofilm permeation agent and (ii) a nonionic alkoxylated alcohol surfactant having an HLB ranging from about 5 to about 8, wherein a ratio of (i) to (ii) in the concentrate ranges from about 2:1 to about 4:1.
US08536102B2 Gear oil having low copper corrosion properties
A gear oil additive composition and gear oil composition comprising a organic polysulfide having at least 30 wt % of a dialkyl polysulfide compound or mixture of dialkyl polysulfide compounds, a thiadiazole; and at least one ashless phosphorus-containing wear inhibitor compound is disclosed as having low yellow corrosion in axles and transmissions.
US08536098B2 High performance superconducting devices enabled by three dimensionally ordered nanodots and/or nanorods
Novel articles and methods to fabricate same with self-assembled nanodots and/or nanorods of a single or multicomponent material within another single or multicomponent material for use in electrical, electronic, magnetic, electromagnetic and electrooptical devices is disclosed. Self-assembled nanodots and/or nanorods are ordered arrays wherein ordering occurs due to strain minimization during growth of the materials. A simple method to accomplish this when depositing in-situ films is also disclosed. Device applications of resulting materials are in areas of superconductivity, photovoltaics, ferroelectrics, magnetoresistance, high density storage, solid state lighting, non-volatile memory, photoluminescence, thermoelectrics and in quantum dot lasers.
US08536091B2 System for protection of plants from pathogens using alkamides
System, including methods compositions, and kits, for controlling the growth of fungi and other pathogens in plants using at least one alkamide, which may function by increasing or eliciting natural defense mechanisms of the plants against such pathogens.
US08536088B2 Method and apparatus for forming image, surface-property-modifying sheet, and thermal transfer sheet
In an image-forming method, a ribbon-shaped thermal transfer sheet with a dye layer and a protective material layer arranged side-by-side in the longitudinal direction is moved, and thermal energy is applied from a thermal head while arranging a recording medium to face the dye layer to thermally transfer the dye layer onto the recording medium to form an image. Thermal energy is applied while arranging the image to face the protective material layer to thereby form a protective layer on the image by thermal transfer. A ribbon-shaped surface-property-modifying sheet including a surface-property-modifying region for modifying the surface of the protective layer is moved, and the protective layer is aligned with the surface-property-modifying region of the surface-property-modifying sheet. Heat and pressure are applied from the thermal head and the surface-property-modifying sheet is detached after cooling to modify the surface condition of the protective layer.
US08536083B2 Olefin epoxidation process, a catalyst for use in the process, a carrier for use in preparing the catalyst, and a process for preparing the carrier
A process is provided for preparing a carrier which process comprises incorporating into the carrier at any stage of the carrier preparation a strength-enhancing additive. Also provided is the resultant carrier having incorporated therein a strength-enhancing additive and a catalyst comprising the carrier. Also provided is a process for the epoxidation of an olefin employing the catalyst. Also provided is a method of using the olefin oxide so produced for making a 1,2-diol, a 1,2-diol ether or an alkanolamine.
US08536082B2 Dehydrogenation catalyst preparation by dry impregnation
The invention relates to a method of preparing a dehydrogenation catalyst comprising a group VIII metal, a group IVA metal and a refractory oxide support. The method comprises stages of preparing the dry impregnation aqueous solution containing said group VIII metal, ammonia, either in solution or in gas form, and a complexing agent. It then comprises stages of aging the aqueous solution, of dry impregnation of the support, of maturing the impregnated support, of drying the impregnated support and of calcining the dried support.
US08536070B2 Vapor deposition of silicon dioxide nanolaminates
This invention relates to materials and processes for thin film deposition on solid substrates. Silica/alumina nanolaminates were deposited on heated substrates by the reaction of an aluminum-containing compound with a silanol. The nanolaminates have very uniform thickness and excellent step coverage in holes with aspect ratios over 40:1. The films are transparent and good electrical insulators. This invention also relates to materials and processes for producing improved porous dielectric materials used in the insulation of electrical conductors in microelectronic devices, particularly through materials and processes for producing semi-porous dielectric materials wherein surface porosity is significantly reduced or removed while internal porosity is preserved to maintain a desired low-k value for the overall dielectric material. The invention can also be used to selectively fill narrow trenches with low-k dielectric material while at the same time avoiding deposition of any dielectric on the surface area outside of the trenches.
US08536067B2 Semiconductor device and method for manufacturing the same
A memory element is formed by providing an organic compound between a pair of upper and lower electrodes. However, when the electrode is formed over a layer containing an organic compound, a temperature is limited because the layer containing the organic compound can be influenced depending on a temperature for forming the electrode. A forming method for the electrode is limited due to this limitation of a temperature. Therefore, there are problems that an expected electrode cannot be formed, and miniaturization of an element is inhibited. A semiconductor device includes a memory element and a switching element which are provided over a substrate having an insulating surface. The memory element includes first and second electrodes, and a layer containing an organic compound, which are provided on the same plane. A current flows from the first electrode to the second electrode. The first electrode is electrically connected to the switching element.
US08536066B2 Methods of forming SiC MOSFETs with high inversion layer mobility
Methods of forming an oxide layer on silicon carbide include thermally growing an oxide layer on a layer of silicon carbide, and annealing the oxide layer in an environment containing NO at a temperature greater than 1175° C. The oxide layer may be annealed in NO in a silicon carbide tube that may be coated with silicon carbide. To form the oxide layer, a preliminary oxide layer may be thermally grown on a silicon carbide layer in dry O2, and the preliminary oxide layer may be re-oxidized in wet O2.
US08536063B2 MRAM etching processes
Various embodiments of the invention relate to etching processes used in fabrication of MTJ cells in an MRAM device. The various embodiments can be used in combination with each other. The first embodiment adds a hard mask buffer layer between a hard mask and a top electrode. The second embodiment uses a multilayered etching hard mask. The third embodiment uses a multilayered top electrode structure including a first Cu layer under a second layer such as Ta. The fourth embodiment is a two-phase etching process used for the bottom electrode to remove re-deposited material while maintaining a more vertical sidewall etching profile. In the first phase the bottom electrode layer is removed using carbonaceous reactive ion etching until the endpoint. In the second phase an inert gas and/or oxygen plasma is used to remove the polymer that was deposited during the previous etching processes.
US08536061B2 Semiconductor device manufacturing method
According to one embodiment, a semiconductor device manufacturing method includes collectively etching layers of a multilayered film including silicon layers and silicon oxide films alternately stacked on a semiconductor substrate. The etching gas of the etching contains at least two types of group-VII elements and one of a group-III element, a group-IV element, a group-V element, and a group-VI element, the energy of ions entering the semiconductor substrate when performing the etching is not less than 100 eV, and an addition ratio of the group-III element, the group-IV element, the group-V element, the group-VI element, and the group-VII element to the group-VII element is 0.5 (inclusive) to 3.0 (inclusive).
US08536057B2 Thin film deposition apparatus and method of manufacturing organic light emitting device by using the same
A thin film deposition apparatus and a method of manufacturing an organic light emitting device (OLED) using the thin film deposition apparatus. The thin film deposition apparatus includes a deposition source; a first nozzle in which a plurality of first slits are formed in one direction; a second nozzle in which a plurality of second slits are formed in the one direction; a second nozzle frame combined with the second nozzle to support the second nozzle; a first barrier wall assembly including a plurality of first barrier walls disposed in the one direction to form a space between the first nozzle and the second nozzle; and a second barrier wall assembly having a plurality of second barrier walls disposed in the one direction and a second barrier wall frame to support the second barrier walls, the second barrier wall assembly disposed at one side of the first barrier wall assembly, wherein the second barrier walls are mounted on the second barrier wall frame in the one direction and the second barrier walls slide on the second barrier wall frame.
US08536051B2 Manufacture method for semiconductor device
A semiconductor device manufacture method includes: forming a first film above a semiconductor substrate; forming a first mask film above the first film; patterning the first mask film; executing a plasma process for a side wall of the patterned first mask film to transform the side wall into a transformed layer; after the plasma process, forming a second mask film covering the first mask film; etching the second mask film to remove the second mask film above the first mask film and leave the second mask film formed on the side wall; after the etching the second mask film, removing the transformed layer; and after the removing the transformed layer, etching the first film by using the first mask film and the second mask film as mask.
US08536045B2 Reflow method
A reflow method of a solder ball provided to a treatment object may include providing a coil, applying a current to the coil, and moving the treatment object through an internal space surrounded by the coil.
US08536043B2 Reduced S/D contact resistance of III-V MOSFET using low temperature metal-induced crystallization of n+ Ge
Embodiments of this invention provide a method to fabricate an electrical contact. The method includes providing a substrate of a compound Group III-V semiconductor material having at least one electrically conducting doped region adjacent to a surface of the substrate. The method further includes fabricating the electrical contact to the at least one electrically conducting doped region by depositing a single crystal layer of germanium over the surface of the substrate so as to at least partially overlie the at least one electrically conducting doped region, converting the single crystal layer of germanium into a layer of amorphous germanium by implanting a dopant, forming a metal layer over exposed surfaces of the amorphous germanium layer, and performing a metal-induced crystallization (MIC) process on the amorphous germanium layer having the overlying metal layer to convert the amorphous germanium layer to a crystalline germanium layer and to activate the implanted dopant. The electrical contact can be a source or a drain contact of a transistor.
US08536042B2 Method of forming a topside contact to a backside terminal of a semiconductor device
A process for forming a vertically conducting semiconductor device includes providing a semiconductor substrate having a topside surface and a backside surface. The semiconductor substrate serves as a terminal of the vertically conducting device for biasing the vertically conducting device during operation. The process also includes forming an epitaxial layer extending over the topside surface of the semiconductor substrate but terminating prior to reaching an edge of the semiconductor substrate so as to form a recessed region along a periphery of the semiconductor substrate. The method also includes forming an interconnect layer extending into the recessed region but terminating prior to reaching an edge of the semiconductor substrate. The interconnect layer electrically contacts the topside surface of the semiconductor substrate in the recessed region to thereby provide a topside contact to the semiconductor substrate.
US08536039B2 Nano-crystal gate structure for non-volatile memory
A non-volatile memory device is disclosed having a charge storage layer that incorporates a plurality of nano-crystals. A substrate having a source region and a drain region is provided. Select and control gates are formed on the substrate. The charge storage layer is provided between the control gate and the substrate. The nano-crystals in the charge storage layer have a size of about 1 nm to about 10 nm, and may be formed of Silicon or Germanium. Writing operations are accomplished via hot electron injection, FN tunneling, or source-side injection. Erase operations are accomplished using FN tunneling. The control gate is formed of a single layer of polysilicon, which reduces the total number of processing steps required to form the device, thus reducing cost.
US08536037B2 Electrically responsive device
Electrically responsive devices and methods for fabricating electrically responsive devices involves applying an electrically responsive material (e.g., an electroactive material) over at least a portion of a surface of a substrate material and applying an electrode material over at least a portion of a surface of the electrically responsive material. At least one region of the electrode material is selectively removed exposing the electrically responsive material. At least some of the electrically responsive material is selectively removed in a region corresponding to the at least one region of the electrode material.
US08536032B2 Formation of embedded stressor through ion implantation
An extremely-thin silicon-on-insulator transistor includes a buried oxide layer above a substrate. The buried oxide layer, for example, has a thickness that is less than 50 nm. A silicon layer is above the buried oxide layer. A gate stack is on the silicon layer includes at least a gate dielectric formed on the silicon layer and a gate conductor formed on the gate dielectric. A gate spacer has a first part on the silicon layer and a second part adjacent to the gate stack. A first raised source/drain region and a second raised source/drain region each have a first part that includes a portion of the silicon layer and a second part adjacent to the gate spacer. At least one embedded stressor is formed at least partially within the substrate that imparts a predetermined stress on a silicon channel region formed within the silicon layer.
US08536027B2 Method for making a semi-conducting substrate located on an insulation layer
A method for making a silicon layer extending on an insulation layer, including the steps of forming a silicon-germanium layer on at least a portion of a silicon wafer; transforming portions of the silicon-germanium layer into porous silicon pads; growing a monocrystalline silicon layer on the silicon-germanium layer and on the porous silicon pads; removing the silicon-germanium layer; oxidizing the porous silicon pads; and depositing an insulation material on the silicon layer.
US08536024B2 Processing method for a workpiece, dividing method for a workpiece, and laser processing apparatus
Provided are a processing method for forming division originating points in a workpiece and a laser processing apparatus performing the method, which are capable of reducing light absorption in a processing trail, increasing light extraction efficiency from sapphire, and performing high speed processing. A pulsed laser beam is irradiated to a workpiece so that irradiation regions for each of unit pulsed beams of the pulsed laser beam of ultra-short pulse are formed discretely in the workpiece, and cleavage or parting of the workpiece is sequentially generated between the irradiation regions by a shock or a stress when each of unit pulsed beam is irradiated at an irradiation point, to thereby form originating points for division in the workpiece.
US08536023B2 Method of manufacturing a semiconductor device and structure
A method of manufacturing semiconductor wafers, the method including: providing a donor wafer including a semiconductor substrate; performing a lithography step and processing the donor wafer; and performing at least two subsequent steps of layer transfer out of the donor wafer, each layer transfer step producing a transferred layer, where each of the transferred layers had been affected by the lithography step, and where each of the transferred layer includes a plurality of transistors with side gates, and where the layer transfer includes an ion-cut, the ion-cut including an ion implant thru the transistors.
US08536021B2 Trap rich layer formation techniques for semiconductor devices
A trap rich layer for an integrated circuit chip is formed by chemical etching and/or laser texturing of a surface of a semiconductor layer. In some embodiments, a trap rich layer is formed by a technique selected from the group of techniques consisting of laser texturing, chemical etch, irradiation, nanocavity formation, porous Si-etch, semi-insulating polysilicon, thermal stress relief and mechanical texturing. Additionally, combinations of two or more of these techniques may be used to form a trap rich layer.
US08536020B2 Combination of a substrate and a wafer
The invention pertains to a combination of a substrate and a wafer, wherein the substrate and the wafer are arranged parallel to one another and bonded together with the aid of an adhesive layer situated between the substrate and the wafer, and wherein the adhesive is chosen such that its adhesive properties are neutralized or at least diminished when a predetermined temperature is exceeded. According to the invention, the adhesive layer is only applied annularly between the substrate and the wafer in the edge region of the wafer.
US08536019B2 Semiconductor devices having encapsulated isolation regions and related fabrication methods
Apparatus and related fabrication methods are provided for semiconductor device structures having encapsulated isolation regions. An exemplary method for fabricating a semiconductor device structure involves the steps of forming an isolation region of a first dielectric material in the semiconductor substrate adjacent to a first region of the semiconductor material, forming a first layer of a second dielectric material overlying the isolation region and the first region, and removing the second dielectric material overlying the first region leaving portions of the second dielectric material overlying the isolation region intact. The isolation region is recessed relative to the first region, and the second dielectric material is more resistant to an etchant than the first dielectric material.
US08536010B2 Method for making a disilicide
Methods for fabricating a semiconductor device are disclosed. A metal-rich silicide and/or a mono-silicide is formed on source/drain (S/D) regions. A millisecond anneal is provided to the metal-rich silicide and/or the mono-silicide to form a di-silicide with limited spikes at the interface between the silicide and substrate. The di-silicide has an additive which can lower the electron Schottky barrier height.
US08536009B2 Differential threshold voltage adjustment in PMOS transistors by differential formation of a channel semiconductor material
In sophisticated semiconductor devices, high-k metal gate electrode structures may be provided in an early manufacturing stage wherein the threshold voltage adjustment for P-channel transistors may be accomplished on the basis of a threshold voltage adjusting semiconductor alloy, such as a silicon/germanium alloy, for long channel devices, while short channel devices may be masked during the selective epitaxial growth of the silicon/germanium alloy. In some illustrative embodiments, the threshold voltage adjustment may be accomplished without any halo implantation processes for the P-channel transistors, while the threshold voltage may be tuned by halo implantations for the N-channel transistors.
US08536006B2 Logic and non-volatile memory (NVM) integration
A method includes forming a gate dielectric over a substrate in an NVM region and a logic region; forming a first conductive layer over the gate dielectric in the NVM region and the logic region; patterning the first conductive layer in the NVM region to form a select gate; forming a charge storage layer over the select gate in the NVM region and the first conductive layer in the logic region; forming a second conductive layer over the charge storage layer in the NVM region and the logic region; removing the second conductive layer and the charge storage layer from the logic region; patterning the first conductive layer in the logic region to form a first logic gate; and after forming the first logic gate, patterning the second conductive layer in the NVM region to form a control gate which overlaps a sidewall of the select gate.
US08536005B2 Semiconductor integrated circuit device and manufacturing method thereof
Various methods are proposed for forming a gate insulation film, a metal gate layer, and others separately in an N-channel region and a P-channel region of an integrated circuit device having a CMIS or CMOS structure using a metal gate. One of the problems of the methods however has been that the process becomes complex. The present invention is that, in a manufacturing method of a CMOS integrated circuit device, a titanium-based nitride film for adjusting the electrical properties of a high-permittivity gate insulation film before a gate electrode film is formed includes a lower film containing a comparatively large quantity of titanium and an upper film containing a comparatively large quantity of nitrogen in an N-channel region and a P-channel region.
US08535999B2 Stress memorization process improvement for improved technology performance
Semiconductor substrate with a deformed gate region and a method for the fabrication thereof. The semiconductor substrate has improved device performance compared to devices without a deformed gate region and decreased dopant loss compared to devices with deformed source/drain regions.
US08535997B2 Wiring structure, thin film transistor substrate, method for manufacturing thin film transistor substrate, and display device
Provided is a direct contact technology by which a barrier metal layer between a Cu alloy wiring composed of pure Cu or a Cu alloy and a semiconductor layer can be eliminated, and the Cu alloy wiring can be directly and surely connected to the semiconductor layer within a wide process margin. The wiring structure is provided with the semiconductor layer and the Cu alloy film composed of pure Cu or the Cu alloy on a substrate in this order from the substrate side. A laminated structure is included between the semiconductor layer and the Cu alloy film. The laminated structure is composed of an (N, C, F) layer, which contains at least one element selected from among a group composed of nitrogen, carbon and fluorine, and a Cu—Si diffusion layer, which contains Cu and Si, in this order from the substrate side. Furthermore, at least the one element selected from among the group composed of nitrogen, carbon and fluorine is bonded to Si contained in the semiconductor layer.
US08535996B2 Substrate having a charged zone in an insulating buried layer
Embodiments of the invention relate to substrates comprising a base wafer, an insulating layer and a top semiconductor layer, wherein the insulating layer comprises at least a zone wherein a density of charges is in absolute value higher than 1010 charges/cm2. The invention also relates to processes for making such substrates.
US08535995B2 Method of manufacturing organic light-emitting display device
A method of manufacturing an organic light-emitting display device includes forming a silicon layer and a gate insulating film over a substrate having a transistor region and a capacitor region; forming a halftone photoresist over the substrate; patterning the silicon layer and the gate insulating film; forming a residual photoresist by subjecting the halftone photoresist to an ashing process to leave part of the halftone photoresist over the transistor region; and doping at least a portion of the silicon layer with impurities by applying the impurities over an entire region of the substrate.
US08535992B2 Thyristor random access memory device and method
Memory devices and methods of making memory devices are shown. Methods and configurations as shown provide folded and vertical memory devices for increased memory density. Methods provided reduce a need for manufacturing methods such as deep dopant implants.
US08535989B2 Embedded semiconductive chips in reconstituted wafers, and systems containing same
A reconstituted wafer includes a rigid mass with a flat surface and a base surface disposed parallel planar to the flat surface. A plurality of dice are embedded in the rigid mass. The plurality of dice include terminals that are exposed through coplanar with the flat surface. A process of forming the reconstituted wafer includes removing some of the rigid mass to expose the terminals, while retaining the plurality of dice in the rigid mass. A process of forming an apparatus includes separating one apparatus from the reconstituted wafer.
US08535980B2 Method for producing vias in fan-out wafers using dry film and conductive paste, and a corresponding semiconductor package
A process for manufacturing semiconductor packages is provided, that includes drilling blind apertures in a reconstituted wafer, adhering a dry film resist on the wafer over the apertures, and patterning the film to expose a space around each of the apertures. The apertures and spaces are then filled with conductive paste by wiping a quantity of the paste across a surface of the film so that paste is forced into the spaces and apertures. The spaces around the apertures define contact pads whose thickness is constrained by the thickness of the film, preferably to about 10 μm or less. To prevent paste from trapping air pockets in the apertures, the wiping process can be performed in a chamber from which much or all of the air has been evacuated. After curing the paste, the wafer is thinned from the back to expose the cured paste in the apertures.
US08535979B2 Method for manufacturing substrate for semiconductor element
A manufacturing method of a semiconductor element substrate including: forming a first photoresist pattern on a first surface of a metallic plate, to form a semiconductor element mounting part, a semiconductor element electrode connection terminal, a wiring, an outer frame part, and a slit; forming a second photoresist pattern on the second surface of the metallic plate; forming the slit by half etching to connect the metallic chip with a four corners of the outer frame part; forming a plurality of concaved parts on the second surface of the metallic plate; forming a resin layer by injecting a resin to the plurality of concaved parts; and etching the first surface of the metallic plate and forming the semiconductor element electrode connection terminal and the outer frame.
US08535977B2 Semiconductor device manufacturing method
According to one embodiment, a semiconductor device manufacturing method includes producing a first substrate with an electrode, producing a second substrate with a through hole, stacking the second substrate on the first substrate, with an insulating layer intervening between the first substrate and the second substrate, making a hole reaching the electrode in the insulating layer under the through hole by etching the insulating layer with the second substrate as a mask, and filling the through hole and the hole with conductive substance.
US08535974B2 Hole transport compositions and related devices and methods (II)
A composition comprising: at least one compound comprising a hole transporting core, wherein the core is covalently bonded to a first arylamine group and also covalently bonded to a second arylamine group different from the first, and wherein the compound is covalently bonded to at least one intractability group, wherein the intractability group is covalently bonded to the hole transporting core, the first arylamine group, the second arylamine group, or a combination thereof, and wherein the compound has a molecular weight of about 5,000 g/mole or less. Blended mixtures of arylamine compounds, including fluorene core compounds, can provide good film formation and stability when coated onto hole injection layers. Solution processing of OLEDs is a particularly important application.
US08535969B2 Solar cell and manufacturing method thereof
A method for manufacturing a solar cell including a photovoltaic layer, a first electrode layer, a second electrode layer, an insulating layer and a light-transparent conductive layer is provided. The photovoltaic layer has a first surface and a second surface. The first electrode layer having at least one gap is disposed on the first surface, wherein the at least one gap exposes a portion of the photovoltaic layer. The second electrode layer is disposed on the second surface. The insulating layer having a plurality of pores is located on the photovoltaic layer exposed by the at least one gap, wherein the holes expose a portion of the photovoltaic layer. The light-transparent conductive layer covers the insulating layer and is connected with the first electrode layer. The transparent electrode is connected with the photovoltaic layer through at least a part of the pores.
US08535962B2 Method for making a light-emitting microelectronic device with semi-conducting nanowires formed on a metal substrate
A process of making a microelectronic light-emitting device, including: a) growth on a metallic support of multiple wires based on one or more semi-conducting materials designed to emit radiant light, and b) formation of at least one electrical conducting zone of contact on at least one of the wires.
US08535960B2 Method for packaging light emitting diode having fluorescent material directly coated on LED die thereof
A method for packaging an LED, includes steps: providing a substrate; arranging an LED die on the substrate; forming a photoresist layer on the substrate to cover the LED die; arranging a mask directly on the photoresist layer; exposing the photoresist layer with the mask to a radiation source; removing the mask and the unexposed portion of the photoresist layer formerly sheltered by the mask, thereby leaving the exposed portion of the photoresist layer formerly unsheltered by the mask on the substrate, wherein the remained exposed portion of the photoresist layer surrounds the LED die; spraying fluorescent material toward the LED die surrounded by the remained exposed portion of the photoresist layer; removing the remained exposed portion of the photoresist layer; and finally encapsulating the LED die covered by the fluorescent material.
US08535953B2 Process for selectively patterning a magnetic film structure
Processes for selectively patterning a magnetic film structure generally include selectively etching an exposed portion of a freelayer disposed on a tunnel barrier layer by a wet process, which includes exposing the freelayer to an etchant solution comprising at least one acid and an organophosphorus acid inhibitor or salt thereof, stopping on the tunnel barrier layer.
US08535946B2 Biomarker to measure drug efficacy in enteropathic disease
The response of a patient with an enteropathic disease to therapy, particularly a candidate therapy in a clinical trial setting, is assessed by detecting the ability of the patient to metabolize an orally administered CYP3A substrate. The CYP3A metabolism may be monitored in a variety of ways. Conveniently, the appearance of a metabolite of the CYP3A substrate is detected in a patient sample over a period of time following oral administration, e.g. in urine, plasma, breath, saliva, etc. The CYP3A substrate is optionally labeled, e.g. with an isotopic, fluorescent, etc. label.
US08535945B2 System and method for concentrating samples
A system and method for concentrating samples. The system can include a first container adapted to contain a sample. The first container can include a first portion and a second portion adapted to be removably coupled to the first portion. The system can further include a second container comprising the second portion and a third portion adapted to be removably coupled to the second portion. The method can include centrifuging the first container in a first orientation toward the second portion of the first container; retaining a concentrate of the sample in the second portion of the first container; and centrifuging the second container in a second orientation toward the third portion of the second container, such that the concentrate retained in the second portion is moved into the third portion of the second container, the second orientation being different from the first orientation.
US08535944B2 Culturing embryonic stem cells, embryonic stem-like cells, or induced pluripotent stem cells with a Muc1 or Muc1* ligand
The present application describes a method of culturing, expanding or growing stem or stem-like cells or induced pluripotent stem cells on a surface, including attaching the cells to the surface through a ligand that binds to the surface and the cells.
US08535939B2 Transfection vector
The present invention relates to a secretory signal, a plasmid containing the secretory signal, a transformed anaerobic bacterium transformed with said plasmid, a gene transfer carrier consisting of said anaerobic bacterium, and a pharmaceutical composition containing said carrier.
US08535936B2 Vessels for mixing bioprocessing materials
A flexible vessel for mixing a bioprocessing fluid has contact points or adhesions between its front and back walls to promote and guide flow patters for mixing the contents.
US08535934B2 Systems and methods for ex vivo organ care
The invention, in various embodiments, provides systems, methods and solutions using an organ ex vivo.
US08535933B2 Method and process for cleaning pipes and components in a piped medical vacuum system
A method and process is provided to help increase flow within the piping of a clinical vacuum system under low flow inlet conditions and to re-establish flow under zero flow inlet conditions, among other things. The method and process broadly uses the steps of isolating and accessing the piping of the clinical vacuum system, introducing an enzymatic solution to the piping, and then extracting the solution following exposure of the solution to the piping to remove complex organic materials from the piping. A portable collection canister can be used to measure the amount of enzymatic solution that is put into the piping and removed from the piping to ensure that the system is dry. The collection canister can be connected via hose to a zone valve box of the system or to a service valve of the system.
US08535929B2 Parvovirus having a CPG-enriched genome useful for cancer therapy
A parvovirus characterized by a CpG-enriched genome, wherein the genome contains at least 2 additional CpG inserts that are not present in the wild type genome is described as well as the use of said parvovirus, e.g., a parvovirus based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species for the preparation of a pharmaceutical composition, e.g., for the treatment of cancer, preferably pancreas carcinoma, hepatoma or lymphoma.
US08535927B1 Micrococcineae serine protease polypeptides and compositions thereof
The present invention provides novel serine proteases, novel genetic material encoding these enzymes, and proteolytic proteins obtained from Micrococcineae spp., including but not limited to Cellulomonas spp. and variant proteins developed therefrom. In particular, the present invention provides protease compositions obtained from a Cellulomonas spp, DNA encoding the protease, vectors comprising the DNA encoding the protease, host cells transformed with the vector DNA, and an enzyme produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising protease(s) obtained from a Micrococcineae spp., including but not limited to Cellulomonas spp. In alternative embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These mutant proteases also find use in numerous applications.
US08535924B2 Granules with reduced dust potential comprising an antifoam agent
A granule with an allergenic component has reduced dust by including antifoam added during the production of the granule. The antifoam may be dispersed throughout the granule or added to one of the components of the granule. The granule with antifoam produces at least 30% less dust than a comparable granule produced according to a process in which no antifoam is added.
US08535913B2 Soluble composition for promoting hair growth produced by hypoxic culture of fibroblasts cells
The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic conditions on a biocompatible three-dimensional surface in vitro. The culturing method produces both soluble and non-soluble fractions, which may be used separately or in combination to obtain physiologically acceptable compositions useful in a variety of medical and therapeutic applications.
US08535912B2 Chimeric fibroblast growth factors with altered receptor specificity
The present invention is directed to novel chimeric fibroblast growth factor (FGF) polypeptides, novel DNA encoding chimeric FGF polypeptides, and to the recombinant production of chimeric FGF polypeptides, and to methods, compositions and assays utilizing chimeric FGF polypeptides for the therapeutic treatment of metabolic-related disorders and other conditions, and for producing pharmaceutically active compositions including chimeric FGF polypeptides, the compositions having therapeutic and pharmacologic properties including those associated with the treatment of metabolic-related disorders and other conditions.
US08535910B2 Halohydrin dehalogenases and related polynucleotides
The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
US08535904B2 Method of enhancing skin barrier function
A method for adjusting calcium ion in epidermis is described. The method involves applying a material for enhancing skin barrier function to the skin of a subject. Appropriate materials include Pimpinella extract, Asteroidea extract, L-Carnitine, Royal jelly hydrolysate, Pellicer, Palmaria extract, ε, γ-Glutamyl lysine, Coptis japonica extract and citrus aurantium peel extract
US08535901B2 Peptidase substrates
The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH: according to which: Y1 is a peptide, H or an alkyl; W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination thereof; n=0, 1 or 2; U and V are N, N+R or CZ4, R being H, alkyl, aralkyl, aryl, alkanoyl or alkylsulfonyl; Z1, Z2, Z3 and Z4 being independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulfonyl, including the carboxyl or sulfonyl esters or amides, and salts thereof.
US08535899B2 Assay for identifying a modulator of HIF hydroxylase
A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
US08535898B2 Thrombin substrate and assay for determining the level of bioactive thrombin in a sample
Substrates for thrombin and assays for determining the level of bioactive thrombin in a sample are disclosed, wherein the substrate has the general formula: A-X—Z-A′ wherein one of either A or A′ comprises a luminescent chelate and the other one of A or A′ comprises a first partner of a binding pair, X forms a tri- or tetra-peptide, and Z comprises a linker.
US08535892B2 Binding molecules for human factor VIII and factor VIII-like proteins
It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.
US08535889B2 Digital analyte analysis
The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
US08535887B2 Genetic markers associated with interferon-alpha response
The present invention provides genetic markers on human chromosome 19 that are associated with a beneficial response to interferon alpha (IFN-α). These IFN-α response markers are useful, inter alia, to identify patients who are most likely to benefit from treatment with IFN-α pharmaceutical compositions and drug products, in methods of treating patients having a disease susceptible to treatment with an IFN-α, and in methods for selecting the most appropriate therapy for such patients.
US08535886B2 Methods and compositions for nucleic acid sample preparation
Provided are methods and compositions for the production of linear single-stranded nucleic acids, which can be used as templates in high-throughput sequencing systems. Also provided are methods and compositions for the production of closed single-stranded nucleic acid loops, which can be used as templates in high-throughput sequencing systems.
US08535885B2 Detection of disease related genes
The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino acids, amino acid analogs or derivatives, or substances recognized by the protein synthesizing machinery. Markers may comprise cleavable moieties, detectable labels, reporter properties wherein markers incorporated into protein can be distinguished from unincorporated markers, or coupling agents which facilitate the detection and isolation of nascent protein from other components of the translation system. The invention also comprises proteins prepared using misaminoacylated tRNAs which can be utilized in pharmaceutical compositions for the treatment of diseases and disorders in humans and other maninials, and kits which may be used for the detection of diseases and disorders.
US08535881B2 High speed parallel molecular nucleic acid sequencing
A method and device is disclosed for sequencing of nucleic acid molecules. A nucleic acid molecule is exposed to a polymerase in the presence of nucleotides. The polymerase carries a donor fluorophore, and each type of nucleotide carries a distinguishable acceptor fluorophore characteristic of the particular type of nucleotide. As the polymerase incorporates individual nucleic acid molecules into a complementary strand, a laser continuously irradiates the donor fluorophore, at a wavelength that causes it to emit an emission signal. The emission signal from the polymerase can stimulate any of the donor fluorophores (but not acceptor fluorophores), so that as a nucleotide is added, the acceptor fluorophore emits a signal associated with the type of nucleotide added to the complementary strand. The series of emission signals from the acceptor fluorophores is detected, and correlated with a sequence of nucleotides that correspond to the sequence of emission signals.
US08535872B2 Thermally cured underlayer for lithographic application
An etch resistant thermally curable Underlayer composition for use in a multiplayer lithographic process for producing a photolithographic bilayer coated substrate, the composition being a composition of: (a) a polymer comprising repeating units of Structure I, II and III (b) at least one crosslinking agent; (c) at least one thermal acid generator; and (d) at least one solvent.
US08535866B2 Yellow electrostatic developing toner, developer for electrostatic development, production method of electrostatic developing toner, image forming method and image forming apparatus
A yellow toner includes binder resin particles that do not contain a coloring agent or a release agent and have a shape factor SF1 of about 110 or less, the number of the binder resin particles being about 50 or less per 5,000 electrostatic developing toner particles; inorganic particles that have a median diameter of about 5 nm to about 70 nm in an amount of about 0.01 mass % to about 0.4 mass % based on the mass of the yellow toner; and a yellow coloring agent that has an azo group.
US08535865B2 Stable emissive toner composition system and method
An emissive toner composition for producing an emissive image component of an image indicia on a substrate. The emissive toner composition includes a photoluminescent agent, a charge control agent, and one or more additives, each selected and present in an amount such that when the toner composition is printed to produce an image component on a substrate, the toner composition has stable spectral characteristics. In one embodiment, the emission spectra of the image component printed on the substrate, for irradiation with an excitation energy includes only dominant emission peaks corresponding to one or more emission peaks of the photoluminescent agent. In another embodiment, the image component has a photoluminescent toner stability factor of about greater than or equal to 25.
US08535858B2 Photomask and method for forming overlay mark using the same
The present invention relates to a photomask and a method for forming an overlay mark in a substrate using the same. The photomask comprises a plurality of patterns. At least one of the patterns comprises a plurality of ring areas and a plurality of inner areas enclosed by the ring areas, wherein the light transmittancy of the ring areas is different from that of the inner areas. When the photomask is applied in a photolithography process, the formed overlay mark has a large thickness. Therefore, the contrast is high when a metrology process is performed, and it is easy to find the overlay mark.
US08535854B2 Reflective exposure mask, method of fabricating reflective exposure mask, method of inspecting reflective exposure mask, and method of cleaning reflective exposure mask
According to one embodiment, a reflective exposure mask comprises a first layer formed on a substrate and including a first light absorbing part which absorbs exposure light and a light reflecting part which reflects the exposure light, and a second layer formed on the light reflecting part and including a second light absorbing part which absorbs the exposure light.
US08535852B2 Hologram recording material and hologram recording medium
The present invention provides a hologram recording material and a hologram recording medium that can stably maintain the shape of a recording layer and achieve high diffraction efficiency. A hologram recording material comprising a photoradical polymerizable compound (A), a photopolymerization initiator (B), and a dispersion medium (C). The medium (C) is selected from the group consisting of: a compound of the formula (I): wherein R11 is a divalent C2-4 hydrocarbon group, R12 and R13 each independently represent a C1-10 hydrocarbon group, k, l, m and n are each independently a number of 0 or more and 5 or less; and a compound of the formula (II): wherein R21 represents a divalent C1-6 hydrocarbon group, R22 and R23 each independently represent a C1-12 hydrocarbon group, and at least one of R22 and R23 represents a C5-12 hydrocarbon group.
US08535851B1 Metal-air battery and gas impermeable anodic conductive matrix
A metal-air battery includes a canister and a spiral wound electrode assembly disposed within the canister. The electrode assembly includes an ion permeable and substantially gas impermeable anode, a catalytic cathode, and a dielectric separator disposed between the anode and cathode.
US08535850B2 Fuel container for fuel cell
A fuel container according to the present invention includes a container body (15), a fuel (10) provided in the container body (15), a draining port (9) provided to the container body (15) for supplying the fuel (10) to the outside of the container body (15), a fluid introduction unit (19) which introduces into the container body (15) a fluid corresponding to flow-out of the fuel (10) from the draining port (9), and a swelling member (17) which connects to the fluid introduction unit (19) and swells in the container body (15) by absorbing the fluid.
US08535849B2 Electrochemical cell and fuel cell using an ionic conductor
An electrochemical cell includes an electrolyte membrane containing an ionic conductor. The ionic conductor includes: (a) a cation expressed by one of Formulae (1) and (2): R1R2R3HX+  (1) where, in Formula (1), X indicates any one of N and P, and R1, R2 and R3 each indicate any one of alkyl groups C1 to C18 except a structure in which R1=R2=R3, R1R2HS+  (2) where, in Formula (2), R1 and R2 each indicate any one of alkyl groups C1 to C18 except a structure in which R1=R2; and (b) an anion expressed by Formula (3): R4YOm(OH)n−1O−  (3) where, in Formula (3), Y indicates any one of S, C, N and P, R4 indicates any one of an alkyl group and a fluoroalkyl group, and m and n each indicate any one of 1 and 2.
US08535844B2 Fuel cell module
A fuel cell module structure including a heat exchanger capable of preventing leakage of oxygen containing gas in a flow path and reducing the cost. The module including a power-generating chamber that receives fuel cells and a casing having a generally rectangular shape enclosing the power-generating chamber. Additionally, the right and left side walls and an upper wall of the casing are hollow walls constituted of an outer shell member and an inner shell member disposed parallel to each other with a distance therebetween forming a reaction gas circulation space, the outer and inner shell members are each formed in a U-like cross-sectional shape, and a reaction gas introduction member extends vertically downward from the inner shell member of the upper wall into the power-generating chamber and being communicated with the reaction gas circulation space to introduce a reaction gas into the power-generating chamber.
US08535843B2 Fuel cell bipolar plate for preventing flooding
The present invention provides a fuel cell bipolar plate in which an air gap or a material layer having a heat transfer coefficient lower than that of the bipolar plate is provided so as to reduce total amount of liquid water generated in a fuel cell, thereby preventing the occurrence of flooding and reducing the time required for cold start, enhancing durability, decreasing parasitic purge requirements, and enhancing operational stability.
US08535842B2 Combustion-thawed fuel cell
Combustion heaters having internal combustion chambers are located adjacent the end cells of a stack of fuel cells to directly, conductively heat the end cells during cold start-up of the stack. Similar heater(s) may also be located within the stack when cold starting under extremely cold conditions. A method of combustion thawing a fuel cell stack is described.
US08535841B1 Methods of refurbishing components of a fuel cell stack
Methods for refurbishing components, such as interconnects of a fuel cell stack, include singulating the stack and removing the electrolyte, seals and oxide layer using non-mechanical methods. The various methods of may be used either singly or in combination.
US08535838B2 Power supply device
A power supply device is provided. The power supply device includes a fuel cell, a hydrogen generator, a check valve and an exhaust valve. The fuel cell has a hydrogen inlet and a hydrogen outlet. The hydrogen generator is connected to the hydrogen inlet and used for generating hydrogen. The check valve is disposed in the hydrogen inlet and used for preventing the hydrogen within the fuel cell from flowing to the hydrogen generator, and preventing exterior air from entering the fuel cell. The exhaust valve is disposed in the hydrogen outlet for exhausting the hydrogen within the fuel cell.
US08535836B2 Method of operating a fuel cell system with bypass ports in a fuel processing assembly
Embodiments relate to a fuel cell system. In an embodiment, the fuel cell system includes advanced leak test capabilities. In another embodiment, the fuel cell system includes a system to bypass one or more separation units while permitting the fuel cell system to continue to produce electricity. In another embodiment, the fuel cell system includes an alignment system that permits ease of alignment when a fuel cell module is installed proximate a fuel processing module. In another embodiment, the fuel cell system includes a system of supplying auxiliary fuel from a mobile auxiliary fuel supply. In an embodiment, one or more or all of these embodiments may be practiced together in combination.
US08535830B2 High-powered electrochemical energy storage devices and methods for their fabrication
The present invention relates to electrochemical storage devices, such as supercapacitors, batteries, etc., and more particularly to such devices that comprise an electrochemically active coaxial nanowire. The invention particularly concerns such devices in which the coaxial nanowire comprises an inner core of a transition metal oxide and an axially surrounding outer shell composed of an electroconductive organic polymer, such as poly(3,4-ethylenedioxythiophene) (PEDOT). The invention particularly relates to a facile method for achieving the self-assembly of such coaxial nanowires.
US08535827B2 Set of separators for a lead-acid rechargeable battery
The invention relates to a method for converting a separator processing machine for processing separators for a lead accumulator, comprising the steps of ending a supply of a first separator having a first separator width to the separator processing machine and supplying a second separator having a second separator width that differs from the first separator width to the separator processing machine. According to the invention, the separators comprise a base film body extending along a center line and a plurality of primary ribs, which are raised above the base film body along the center line by a primary rib height and are disposed mirror-symmetrically with respect to the center line, wherein the primary ribs of the second separator with respect to the center line are disposed in the same locations as the primary ribs of the first separator.
US08535826B2 Rechargeable lithium battery
A rechargeable lithium battery includes a positive electrode including a positive active material; a negative electrode including a negative active material; an electrolyte including a lithium salt and a non-aqueous organic solvent; and a separator interposed between the positive and negative electrodes and including a ceramic material having a first metal oxide-containing core and a second metal oxide shell disposed on the surface of the core.
US08535823B2 Cooling device of battery pack
A battery pack including battery cells, a housing to house the battery cells, and a cooling device that cools air flowing through the housing. The cooling device may be installed on an intermediate portion of the housing. The cooling device may include a cooling pipe, in which water flows.
US08535819B2 Internally neutralizing a power source
A battery is disclosed that includes two contact areas, an electrolyte, and an electronically conductive material that, at a neutralization trip point temperature, increases electronic conductivity internal to the battery between the first contact area and the second contact area. In one embodiment, the electronically conductive material is void from being activated external to the battery. In another embodiment, the battery includes a semiconductor material that includes custom doping to provide the increased electron conductivity at the neutralization trip point temperature. In yet another embodiment, the battery includes an insulator for separating the electronically conductive material until a temperature internal to the battery reaches the neutralization trip point temperature, at which point permits the electronically conductive material to increase the electronic conductivity between the first contact area and the second contact area.
US08535807B2 Anti-reflection film and infrared optical element
An anti-reflection film provided on a surface of a chalcogenide glass base includes a first thin film layer and a second thin film layer. The first thin film layer is composed of a single layer of Bi2O3 formed by ion beam assisted deposition. The second thin film layer made of YF3 includes assisted layers and non-assisted layers laminated alternately. The assisted layers are formed by the ion beam assisted deposition, while the non-assisted layers are formed without assistance of an ion beam. The assisted layer is superior in adhesion and surface flatness or smoothness. On the other hand, the non-assisted layer has small internal stress. The second thin film layer functions as a buffer to relieve the internal stress of the first and second thin film layers.
US08535803B2 Colored roofing granules with increased solar heat reflectance, solar heat-reflective shingles, and process for producing same
Solar-reflective roofing granules having deep-tone colors are formed by coating base mineral particles with a coating composition including an infrared-reflective pigment. Color is provided by colored infrared pigment, light-interference platelet pigment, or a metal oxide.
US08535801B2 Fiber for producing three-dimensional, self-interlacing composites
A fiber includes a base having a surface to be impacted by a fluid wave for propelling the fiber forward and a body having a trailing end connected to the base, a leading free end, and a spiral shape causing the fluid wave to rotate the fiber. A locking system causes the fiber to engage and hold at least one other fiber being propelled and rotated by the fluid wave.
US08535799B2 Controlled agglomeration
A process for the preparation of a particulate material by a controlled agglomeration method, i.e. a method that enables a controlled growth in particle size. The method is especially suitable for use in the preparation of pharmaceutical compositions containing a therapeutically and/or prophylactically active substance which has a relatively low aqueous solubility and/or which is subject to chemical decomposition. The process comprising i) spraying a first composition comprising a carrier, which has a melting point of about 5° C. or more which is present in the first composition in liquid form, on a second composition comprising a material in solid form, the second composition having a temperature of at the most a temperature corresponding to the melting point of the carrier and/or the carrier composition and ii) mixing or others means of mechanical working the second composition onto which the first composition is sprayed to obtain the particulate material.
US08535797B2 Method for fabricating electrical circuitry on ultra-thin plastic films
In accordance with the teachings of one embodiment of the present disclosure, a method of forming high-density metal interconnects on flexible, thin-film plastic includes laminating a dry photoresist layer to a substrate. The photoresist-laminated substrate is baked. An assembly is formed by laminating a plastic film to the baked, photoresist-laminated substrate. One or more electrically conductive interconnect layers are processed on a first surface of the laminated plastic film. The processing of the one or more electrically conductive interconnects includes photolithography. The assembly is baked and soaked in a liquid. The processed plastic film is then separated from the substrate.
US08535795B2 Multi-layered coatings, method for the production thereof, and use thereof in the car industry
The present disclosure provides multicoat systems exhibiting ultraviolet (UV) stability after ultraviolet exposure and moisture exposure. The systems comprise at least one primer (G), at least one pigmented coating (P) disposed on a surface of the primer, and at least one ultraviolet (UV) absorber which has an absorption maximum of at least 370 nm. The pigmented coating (P) may be comprised of two or more coatings (P1), (P2) to (Pn). The multicoat systems may also comprise a transparent coating material (T) to form a transparent coating (K). The present multicoat systems demonstrate ultraviolet stability, reduced delamination of the pigmented coat from the primer and are available in a variety of shades for use in the finishing, refinishing and coating of component parts.The present disclosure also provides for a process for producing the multicoat system, and provides for the use of the system.
US08535792B2 Polyetherimide resins with very low levels of residual contamination
Compositions and methods for producing compositions comprising a monoamine-endcapped polyimide component. Based on a gas chromatography mass spectroscopy analysis of a surface rinse of the composition performed at room temperature, the composition can have at least one surface with less than or equal to 5 ppb releasable phosphorous residuals, and less than or equal to 5 ppb releasable volatile organic compound residuals. The composition can also comprise less than or equal to 10 ppb combined releasable residuals. Because of the very low levels of residual contamination, the compositions can be used to produce a variety of articles, including a disk drive.
US08535785B2 Floor tile
A modular plastic floor tile has a body of a first polymer compound and features overmolded onto the body from a second polymer compound. The compounds may be different from each other in hardness and/or color. The features may include raised pads on the upper surface and/or skins on support member cores downwardly depending from the tile lower surface. The pads on the upper surface may be injection-molded from the lower surface through through-holes. Lateral edges of the tile are provided with latches which fit into loops with an interference fit. The loops flex in order to impose a compressive force on mating tile edges. The tile may have an overmolded peripheral seal.
US08535781B2 Friction resistance reducing layer
The present invention relates to a layer for reducing the friction resistance of a fluid relative to an object and for improving the contact of a boundary layer of the fluid flowing past, and thereby increasing the lift, comprising a wave-like approach flow surface repeating in a first direction which comprises means for transporting fluid from the boundary layer of the fluid flowing past to cavities in the wave-like approach flow surface. The present invention further relates to a method for manufacturing such a layer.
US08535779B1 Self-lubricating surfaces for food packaging and food processing equipment
In certain embodiments, the invention relates to an article having a liquid-impregnated surface. The surface includes a matrix of solid features (e.g., non-toxic and/or edible features) spaced sufficiently close to stably contain a liquid therebetween or therewithin, wherein the liquid is non-toxic and/or edible. The article may contain, for example, a food or other consumer product, such as ketchup, mustard, or mayonnaise.
US08535774B2 Release sheet
Disclosed is a release sheet including a substrate and a resin layer formed on the substrate. The resin layer includes: 100 parts by mass of an acid-modified polyolefin resin including an acid-modifying component in a content of 1 to 10% by mass; and 1 to 50 parts by mass of a crosslinking agent and/or 5 to 1000 parts by mass of polyvinyl alcohol. The crosslinking agent is composed of a carbodiimide compound and/or an oxazoline compound.
US08535773B2 Hose for transporting refrigerant
A hose for transporting refrigerant of this invention is a hose comprising an inner tube layer including a gas barrier layer and a rubber layer adjacent to an outer surface of the gas barrier layer. The rubber layer comprises a rubber composition comprising from 1 to 15 parts by mass of an alkylphenol-formaldehyde resin and from 1 to 8 parts by mass of a hydrotalcite per 100 parts by mass of a raw rubber. The raw rubber comprises at least one selected from the group consisting of a BIMS and a butyl rubber and/or a halogenated butyl rubber, which is a copolymer rubber. The gas barrier layer comprises a polyamide resin composition comprising a modified polyamide obtained by blending a polyamide and a carboxyl group-containing modified polyolefin. The hose for transporting refrigerant of this invention has superior adhesion between the gas barrier layer and the rubber layer.
US08535771B2 Device consisting of at least two materials
An apparatus for generating electrical energy includes at least one generator connected to a drive device. The drive device includes at least one guide element for transforming the energy of a flowing medium into a rotational movement. The guide element is arranged in the flow path of the heated exhaust air coming from at least one heat exchanger.
US08535770B2 Pearlescent container
A pearlescent container comprising about 86% to about 99.99% of a thermoplastic material having a Total Luminous Transmittance value of at least about 80%, about 0.01% to about 5% of a siloxane fluid having a viscosity of no greater than about 1,000,000 cst, wherein said thermoplastic material and said siloxane fluid are immiscible, forms a lamellar structure, and have a Refractive Index difference of at least about 0.1.
US08535765B2 Method of producing a low-molecular luminous material dispersant, an apparatus for producing a low-molecular luminous material dispersant and a low-molecular luminous material dispersant
A method of producing a low-molecular luminous material dispersant having: inserting a coat agent in gas phase and an inner gas into a vacuum atmosphere, wherein the coat agent has a strong affinity for a solvent when the coat agent is in liquid phase; heating and vaporizing a low-molecular luminous material in the vacuum atmosphere so as to obtain a mix gas comprising the low-molecular luminous material and inner gas; cooling the mix gas so as to obtain a coat agent in liquid phase; and recovering the coat agent in liquid phase and adding the coat agent in liquid phase into the solvent so as to obtain the low-molecular luminous material dispersant.
US08535758B2 Materials including semiconductor nanocrystals
A composition includes a layer of nanoparticles and a layer of a second material.
US08535753B2 Methods of forming carbon nanotubes
Methods of forming carbon nanotubes include forming a catalytic metal layer on a sidewall of an electrically conductive region, such as a metal or metal nitride pattern. A plurality of carbon nanotubes are grown from the catalytic metal layer. These carbon nanotubes can be grown from a sidewall of the catalytic metal layer. The plurality of carbon nanotubes are then exposed to an organic solvent. This step of exposing the carbon nanotubes to the organic solvent may be preceded by a step of applying centrifugal forces to the plurality of carbon nanotubes. Alternatively, the exposing step may include applying a centrifugal force to the plurality of carbon nanotubes while simultaneously exposing the plurality of carbon nanotubes to an organic solvent.
US08535750B2 Granular lecithins, granular lysolecithins, process for their production and compositions containing them
There is disclosed a granular lecithin and the use in many applications, such as nutraceutical compositions. Also disclosed is a process for producing granular lecithins and compositions containing lecithins.
US08535747B2 Beverage products having steviol glycosides and at least one acid
Beverage products are provided which include rebaudioside A, erythritol, and an acid component. The beverage product has a titratable acidity in the range of about 8.75 to about 10.25, and a pH in the range of about 2.8 to about 3.3. Beverage products disclosed herein achieve a proper sweet/tart ratio to increase sweetness and to reduce tartness and bitterness of beverages made with natural sweeteners.
US08535744B1 Device for making fruit juice and method of producing individual servings thereof
A device and method for creating fruit juice utilizing a flexible bag having an upper fruit receiving portion for receiving a piece of fruit therein and a lower juice receiving portion, such portions separated by a mesh screen. There is a resealable closure member at the top of the fruit receiving portion. The flexible bag with fruit therein is then frozen and later thawed. The fruit receiving portion with fruit therein is squeezed to release juice from the fruit which passes through the mesh screen into the juice receiving portion which is accessible through a channel defined in the fruit receiving portion and mesh screen through which a straw can be passed into the juice receiving portion for drinking the juice.
US08535736B2 Methods and compositions for the treatment of infection or infectious colonization of the eyelid, ocular surface, skin or ear
The instant invention provides methods and compositions for the treatment of infection or infectious colonization of the eyelid and/or ocular surface for the treatment and prevention of ocular disorders and eyelid disorders.
US08535733B2 Compositions and methods for altering stool quality in an animal
The present invention provides compositions and methods for improving stool quality of a puppy by adjusting the balance of metabolizable cations to metabolizable anions consumed by the puppy.
US08535731B2 Use of extracts of the Cassia alata plant
Extracts of the plant Cassia alata are used in cosmetic and/or dermatological skin care preparations. These preparations possess antioxidative and anti-inflammatory properties and exhibit preventive and curative effect on skin aging.
US08535729B2 Natural silver disinfectant compositions
An antimicrobial composition contains a soluble silver salt and an alkanolamine or aminoalcohol. The composition may additionally contain an amino acid or amino acid salt and surfactant. The composition has additional stability and activity compared to prior art silver complexes.
US08535728B2 Colloidal silver composition having antimicrobial properties
Colorless composition comprising silver particles and water, wherein said particles comprise an interior of elemental silver and an exterior of ionic silver oxide, wherein the silver particles are present in the water at a level of about 5-40 ppm, and wherein the composition manifests significant antimicrobial properties. Methods of use of the composition are described. The composition can be incorporated into a hydrogel with essentially no loss of antimicrobial properties.
US08535727B2 Biodegradable non-woven fabric having plant virus encapsulated actives for drug delivery
A biodegradable delivery system for actives such as pharmaceutical drugs. The delivery system includes actives infused into the capsid of a purified plant virus. The loaded capsids are embedding in electrospun biodegradable polymer fibers, forming a nonwoven fabric.
US08535725B2 Porous-wall hollow glass microspheres as carriers for biomolecules
The present invention includes compositions of porous-wall hollow glass microspheres and one or more biomolecules, wherein the one or more biomolecules are positioned within a void location within the hollow glass microsphere, and the use of such compositions for the diagnostic and/or therapeutic delivery of biomolecules.
US08535720B2 Method and apparatus for enhanced size reduction of particles
The present invention provides methods and apparatus for producing particles via supercritical fluid processing. In one embodiment, the method includes expanding a supercritical fluid plasticized melt across a pressure drop to form solid composite particles that are simultaneously dispersed, foamed and cooled, and milling the solid particles produced to achieve the desired size distribution. In another embodiment, a pressure vessel containing a supercritical fluid plasticized melt is depressurized to form a cooled solid porous mass, which is then milled to obtain solid composite particles.
US08535714B2 Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
Compositions, systems and methods for administration of small volume sufentanil drug dosage forms via the oral transmucosal route of a subject for treatment of pain.
US08535712B2 Radiation sensitive liposomes
The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.
US08535710B2 Wound care
A method for treating a wound, and a dressing for wound care management comprising a three-dimensional body of glass-based fibers comprising one or more glass-formers selected from the group consisting of P2O5, SiO2, and B2O3; at least about 25 wt % of the fibers have a diameter between about 200 nm and about 4000 nm, and a length:width aspect ratio of at least about 10. In another form, the glasses are in the form of particles in an ointment or cream applied to a wound. In yet other forms the glasses are employed as fibers formed into sutures for closing a wound, or as particles in a surgical glue for closing a wound.
US08535707B2 Devices and methods for delivering active agents to the osteomeatal complex
Described here are devices, methods, and kits for treating sinusitis and related respiratory conditions by locally delivering active agents to the osteomeatal complex over a sustained period of time. The devices may be passively fixed within the osteomeatal complex and/or include one or more features that actively fix it within the osteomeatal complex. The devices may optionally include a portion that extends into a sinus ostium, sinus cavity, and/or the nasal passage to deliver an active agent.
US08535706B2 Bone implant
A bone implant, and bone implant material, includes a calcium- and oxide-containing artificial graft material in a scaffold, to which melatonin and an optional cell adhesion peptide are absorbed or covalently linked.
US08535703B2 Methods of arthroscopic osteochondral resurfacing
Methods of arthroscopic resurfacing of anatomical tissue utilizing a biological component strengthened with glue or similar material. The biological component is selected from the group consisting of blood, blood components, PRP, bone marrow aspirate (BMA) and autologous conditioned plasma (ACP). The biological component/glue composition may be inserted (by injection and/or by employing a biologic resurfacing mold, for example) into, or in the vicinity of, the anatomical tissue. Upon insertion within, or contact with, the anatomical tissue, the biological component/glue composition is designed to coagulate and solidify (or partially solidify) within minutes, to advance healing or tissue growth of the anatomical tissue. The biological component/glue composition may optionally comprise components such as growth factors, antiseptic chemicals and/or antibiotics and/or electrolytes, or hormones or site-specific hybrid proteins, among others.
US08535699B2 Insect-repelling resin composition and extended-release insect-repelling resin molded product obtained therefrom
In order to provide a controlled-release insect-controlling resin molded product and a insect-controlling resin composition for making such a controlled-release insect-controlling resin molded product that have immediate effectiveness, residual effectiveness, and preservation stability and that are excellent in merchantability and manufacturing control, the present invention uses an insect-controlling resin composition including a polyvinyl chloride resin containing a non-vaporizable insect-controlling component and erucic acid.
US08535697B2 Cosmetic composition
Provided are a cosmetic composition which is an O1/W/O2 emulsion composition and contains, in the oil phases O1 and O2 thereof, fine metal oxide particles having ultraviolet screening ability; and a preparation process of the cosmetic composition.
US08535696B2 Treating eczema and/or psoriasis
The treatment of humans or other mammals for eczema and/or psoriasis using dosage forms or compositions that include cetyl myristate alone or (in admixture or serially) both cetyl myristate and cetyl palmitate.
US08535692B2 Local anesthetic emulsion compositions and methods of making and using the same
Local anesthetic emulsion compositions are provided. The local anesthetic emulsion compositions may include: an oily phase comprising a eutectic mixture of a local anesthetic and an acyclic amide; a surfactant; and an aqueous phase. Also provided are methods of making and using the emulsions.
US08535684B2 Methods of inhibiting HIV infectivity
A method for identifying host genes and encoded proteins for potential targets for therapeutic intervention employs a Gene Search Vector that is either lentivirus or MMLV-based, and can be used to interrogate an entire cell genome without prior knowledge of the genomic sequence. This Random Homozygous Gene Perturbation (RUGP) technique is rapidly verifiable and is used to identify potential host targets for intervention for influenza, HIV and other viral infections. Using Thermal Assymetric Interlaced (TAIL)-PCR, the period for identification of promising targets is reduced from months to weeks or less. Specific targets including PTCH1, Robo1 and Nedd4 are reviewed in detail.
US08535681B2 Sustained drug delivery system
A drug composition comprising a charged moiety coupled to a therapeutic compound is disclosed. The charged moiety is configured to interact with at least one type of component of opposite charge in a biological tissue to create an in situ depot for prolonged drug delivery. The biological tissue may be eye tissue or any tissue containing charged components. Further, a method of treating the human body is disclosed. The method is for introducing into a human body a drug composition comprising a charged moiety coupled to a therapeutic compound. Introduction may be through injection. A method of manufacturing a drug composition comprising a charged moiety coupled to a therapeutic compound is also disclosed.
US08535676B2 Antibody therapy
The present invention provides a composition comprising naked humanized, chimeric, and human anti-CEA antibodies and a therapeutic agent, which is useful for treatment of CEA expressing cancers and other diseases, and methods of use in treatment using this composition.
US08535674B2 Treating breast cancer and inhibiting cancer-associated bone loss with anti-IL-20 antibody
Use of an anti-IL-20 antibody, either alone or in combination with an anti-RANKL antibody, for treating breast cancer and inhibiting cancer-associated bone loss.
US08535666B2 Antibody (11C7) anti Nogo-A and its pharmaceutical use
This invention relates to molecules, such as for example monoclonal antibodies or Fab fragments thereof, which are capable of binding to the human NogoA polypeptide or human NiG or human NiG- or human NogoA_623-640 with a dissociation constant, 1000 nM; polynucleotides encoding such a binding molecule; an expression vector comprising such polynucleotides; the use of such a binding molecule in the treatment of nerve repair, a pharmaceutical composition comprising such a binding molecule; and to a method of treatment of diseases associated with nerve repair.
US08535665B2 Process for identification of molecular mimicry and the uses thereof
The present invention discloses a process for simple and rapid detection and identification of molecular mimicry or mimic antigens or molecules existing in/on humans, animals and plants. The molecular mimicry can be related to infections, autoimmune diseases, cancers, obesity and other disorders. Therefore, novel methods for the diagnosis, prevention, and treatment of infections, autoimmune diseases, cancers, obesity and other disorders obtainable based on these mimic antigens or molecules can be developed. Furthermore, the present invention also reveals a new functional mechanism of vaccine and passive immunity and novel vaccines obtainable based on the new mechanism.
US08535664B2 Method of treating a pathological syndrome and a pharmaceutical agent
The application relates to a pharmaceutical agent comprising homeopathically activated form of antibodies to a pharmaceutically active small molecule, which activated form is obtained by repeated consecutive dilutions; and to a method of treating a disease or condition by administering to a subject in need thereof, a homeopathically activated form of an antibody to a pharmaceutically active small molecule.
US08535661B2 Enzymatically active compositions for suppressing sulfide generation and methods of use thereof
The present invention provides an enzymatically active composition for suppressing sulfide generation. The composition is free from sulfur dehydrogenase and comprises at least one enzyme having sufficient sulfide-production inhibiting activity in an acidic medium to at least inhibit biogenic sulfide production, and an oxidized nitrogenous inorganic salt present in an amount sufficient to act as an electron acceptor for the enzyme. The oxidized nitrogenous inorganic salt preferably is selected from an alkali metal nitrite, an alkaline earth metal nitrite, an alkali metal nitrate, an alkaline earth metal nitrate, or a mixture of two or more of the foregoing salts. The enzymatically active composition is free from viable bacteria and is non-toxic (i.e., has an oral LD50 in rats greater than 1000 mg/Kg of body weight at a concentration of about 25,000 parts per million (ppm) in water). The compositions of the present invention are useful for treating and removing biofilms, as well as inhibiting sulfide production in a variety of aqueous systems.
US08535659B1 Nutritional supplements for pregnant women
The present invention relates to different nutritional supplements to be administered to, or taken by, pregnant women during the first, second and third trimesters of pregnancy.
US08535658B2 Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyltransferase
The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an α (1,3) galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The α galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.
US08535653B2 Articles for the release or emanation of vapors
An article for sequential dispensing of vapors, notably evaporable fragrances, comprises separated first and second liquids (22, 24). Liquid (22) issues first. Its evaporation may be assisted by a wick (26). The simultaneous evaporation of the second liquid is prevented by an intermediate liquid phase (20). As liquid (22) issues the liquid levels change and there comes a point at which the intermediate phase can no longer prevent the second liquid (24) from flowing past it, to the region from which it can be evaporated. Solids, especially gels, may be employed instead of liquids (22, 24).
US08535641B2 Phospholipid analogs as diapeutic* agents and methods thereof
The present invention provides methods and uses of phospholipid ether analogs as diagnostic and therapeutic agents for numerous cancers.
US08535628B2 Exhaust gas purifying catalyst
To overcome the problem of a conventional catalyst and to provide an exhaust gas purifying catalyst that meets the requirement concerning Hg oxidation activity and SO2 oxidation activity; i.e., an exhaust gas purifying catalyst which specifically reduces percent SO2 oxidation, while maintaining percent Hg oxidation at a high level.The invention provides an exhaust gas purifying catalyst which comprises a composition containing oxides of (i) titanium (Ti), (ii) molybdenum (Mo) and/or tungsten (W), (iii) vanadium (V), and (iv) phosphorus (P), wherein the catalyst contains Ti, Mo and/or W, and V in atomic proportions of 85 to 97.5:2 to 10: 0.5 to 10, and has an atomic ratio of P/(sum of V and Mo and/or W) of 0.5 to 1.5, and an exhaust gas purifying method comprising exposing an exhaust gas containing a nitrogen oxide (NOX) and metallic mercury (Hg) to the catalyst in the presence of ammonia as a reducing agent, to thereby perform reduction of NOX contained in the exhaust gas and oxidation of metallic mercury (Hg) contained in the exhaust gas.
US08535627B1 Ketone/water mixtures for NOx removal
The present invention is directed at ketone/water mixtures for treating gas mixtures containing nitric oxides (NOx). The chemical reduction of NOx by the ketone/water mixture affords a relatively less objectionable combustion waste product for discharge into the atmosphere. The gas mixture for treatment of the ketone/water mixture may be preferably regulated to have a level of oxygen of at or below 5.0 vol. %.
US08535624B2 Assay testing diagnostic analyzer
A diagnostic system with a handling system that has a loading bay to receive and hold a plurality of carriers. An identification device is configured to identify an identifying feature of the carriers to determine the type of contents loaded on each carrier. A transporter transports the carriers from the loading bay to a first or second location depending on the determined type of contents on each carrier. The transporter has random access to the plurality of carriers in the loading bay. A diagnostic process is conducted using the contents. A carrier, such a for reagents, has one or more holding portions, at least one of which can be moved or rotated with respect to the body of the carrier for mixing or stirring the contents of a container coupled therewith. Also, a retention member can be associated with a positioning device, such as a carousel, to lock and unlock the carrier with respect thereto.
US08535621B2 Penetrable cap having rib structures
A cap having a plurality of rib structures situated on an inner wall of the cap to facilitate the formation of air passageways as the cap is penetrated by a pipette tip. The air passageways aid in venting air from a fluid-holding vessel closed with the cap.
US08535620B2 Method of filling liquid sample
A method of filling a liquid sample includes: supplying the liquid sample to a first well of a biochip; adhering a cover and the substrate of the biochip in a loop-shaped area surrounding the first well and plural second wells on the substrate; moving the liquid sample from the first well to the second wells through a space between the cover and the substrate by rotating the biochip around a rotation axis in a state in which the biochip is arranged such that a distance from any one of the second wells to the rotation axis in a vertical direction with respect to the rotation axis is longer than a distance from the first well to the rotation axis in the vertical direction with respect to the rotation axis; and sealing the first well and the second wells by adhering the cover to the substrate to thereby seal.
US08535614B2 Reactor and method for producing high-purity granular silicon
The present invention provides a reactor and a method for the production of high purity silicon granules. The reactor includes a reactor chamber; and the reaction chamber is equipped with a solid feeding port, auxiliary gas inlet, raw material gas inlet, and exhaust gas export. The reaction chamber is also equipped with an internal gas distributor; a heating unit; an external exhaust gas processing unit connected between a preheating unit and a gas inlet. The reaction chamber is further equipped with a surface finishing unit, a heating unit and a dynamics generating unit. The reaction is through decomposition of silicon containing gas in densely stacked high purity granular silicon layer reaction bed in relative motion, and to use remaining hear of exhaust gas for reheating. The present invention is to achieve a large scale, efficient, energy saving, continuous, low cost production of high purity silicon granules.
US08535610B2 Apparatus for regenerating catalyst
Disclosed is a catalyst distributor and process for mixing spent catalyst and recycled regenerated catalyst in a regenerator vessel. Mixing is conducted in a confined space to which catalyst is delivered from catalyst conduits protruding through the wall of the regenerator.
US08535609B2 Test element analysis system
A test element analysis system for the analytical investigation of a liquid sample. The test element comprising a carrier film having a first light guide layer having a flat side, a second light guide layer positioned adjacent to the first light guide layer and opposite of the flat side, and a coupling out zone which is part of the flat side of the first light guide layer. A test field is secured to the flat side and is constructed and arranged to receive a liquid sample. The test field comprises a reagent system having a soluble reagent capable of causing an optically measurable change upon reaction with an analyte of the liquid sample, and a detection zone in optical contact with the coupling out zone.
US08535608B2 Analytical system and method for its operation
An analytical system comprising a replaceable magazine (12) for providing a plurality of test units that react to an analyte and a measuring device (14) for processing the test units, wherein the magazine (12) is provided with a code (26) that can be registered by the measuring device (14). In order to enable the simplest possible coding, it is proposed that the code (26) comprises an unique magazine identifier (28) for the magazine (12) and that the measuring device (14) has a magazine-independent test counter (16) which registers the processing of a test unit and a counter memory (18) to store the magazine identifier (28) and a corresponding count of the test counter (16).
US08535605B2 Method of producing a sinter-hardened component
The invention describes a method of producing a sinter-hardened component from a metallic powder containing chromium which is pre-alloyed in particular, comprising the steps of compacting the powder to form a green compact and then sintering the green compact in a reducing sintering atmosphere at a sintering temperature in excess of 1100° C. A gas containing carbon is added to the sintering atmosphere.
US08535604B1 Multifunctional high strength metal composite materials
A method of producing composites of micro-engineered, coated particulates embedded in a matrix of metal, ceramic powders, or combinations thereof, capable of being tailored to exhibit application-specific desired thermal, physical and mechanical properties to form substitute materials for nickel, titanium, rhenium, magnesium, aluminum, graphite epoxy, and beryllium. The particulates are solid and/or hollow and may be coated with one or more layers of deposited materials before being combined within a substrate of powder metal, ceramic or some combination thereof which also may be coated. The combined micro-engineered nano design powder is consolidated using novel solid-state processes that prevent melting of the matrix and which involve the application of varying pressures to control the formation of the microstructure and resultant mechanical properties.
US08535601B2 Composite target material and method for producing the same
A composite target material includes titanium oxide in a range between about 50 wt % and about 85 wt % and the remaining comprising stannic oxide or aluminum oxide or a combination of stannic oxide and aluminum oxide. A method for manufacturing composite target material includes the steps of: providing a mixture made of titanium oxide power in a range between about 40 wt % and about 80 wt %, stannic oxide powder or aluminum oxide in a range between about 15 wt % and about 50 wt %, binder in a range between about 5 wt % and about 10 wt %; pressing the mixture to form a blank; sintering the blank; cooling the blank.
US08535600B2 High temperature-resistant article, method for producing the same, and high temperature-resistant adhesive
A method for producing a high temperature-resistant article comprises an assembling step of foaming an assembly of a first substrate and a second substrate with an adhesive layer interposed therebetween and comprising paste of powder of at least one carbide of niobium carbide, hafnium carbide, tantalum carbide and tungsten carbide; and a bonding step of heating the assembly to bond the first substrate and the second substrate by sintering, thereby obtaining a high temperature-resistant article comprising the assembly after sintering. Moreover, a method for producing a high temperature-resistant article comprises a coating step of coating a slurry comprising powder of at least one carbide of niobium carbide, hafnium carbide, tantalum carbide and tungsten carbide on a surface of a high temperature-resistant substrate; a drying step of drying the substrate after the coating step; and a film-forming step of heating the substrate after the drying step to form a carbide coating film on the surface of the substrate by sintering, thereby obtaining a high temperature-resistant article having the carbide coating film. A high temperature-resistant article of a complicated shape can be easily produced at low costs by these methods.
US08535599B1 Method and apparatus for making a light weight container
An improved lightweight container incorporates a thinner wall structure in an essentially octagonal container having a bottom member, a plurality of sidewalls, a spout, an upwardly converging neck member coupling the sidewalls of the spout, a handle molded into the container and a radiused transiting section between the sidewalls and the spout which eliminates weakened corner sections and improves overall strength to weight ratios.
US08535587B2 Method for manufacturing plugged honeycomb structure
A method for manufacturing a plugged honeycomb structure includes: a step of forming a columnar honeycomb formed body, and a plugging step of forming plugging portions in each of cells of the honeycomb formed body; wherein the plugging step has a plugging slurry injection operation where plugging slurry is injected into the cells by inserting the honeycomb formed body into a bottomed cylindrical inside container containing the plugging slurry and having a Young's modulus of 5 to 550 MPa and a tensile stress of 0.5 to 11 MPa and being disposed in a bottomed cylindrical outside container and by pressing one end portion against the bottom face of the inside container, and then the honeycomb formed body is pulled out from the inside container. There is provided a method for manufacturing a plugged honeycomb structure, the method being capable of inhibiting depression and protrusion of plugging portions.
US08535584B2 Method of manufacturing an automotive interior member
An automotive interior material with high appearance quality and a method of manufacturing the same includes a door trim (automotive interior material) having a flat portion (main-body portion) covering a door panel and an armrest protruding into the vehicle compartment. Molten resin material added with a foaming agent is supplied into a cavity formed between a pair of molds. Then, opening of the pair of molds by a predetermined amount causes the molten resin material in the cavity to foam. An upper surface (vertical wall portion) of the armrest is connected to the flat portion and extends in a thickness direction of the flat portion. A surface of the upper surface facing outward from the vehicle compartment is formed with a recessed portion. During a vehicle collision, an object in the vehicle presses the arm rest formed on the door trim. Then the door trim is broken and deformed in the recessed portion, so that the armrest is crushed, thus absorbing an impact by a collision.
US08535582B2 Method of forming a molded article by wireless control
The present invention relates to a method and molding system (1) for forming a molded plastic article by wireless control. The molding system includes a primary controller (12) that is adapted to engage in wireless communications with the carriage controller (45) of one or more self-propelled carriages (15). Each carriage (15) includes a carriage location indicator (62) that determines the location of the carriage, which is transmitted substantially continuously to the carriage controller (45), and then communicated substantially continuously and wirelessly from the carriage controller to the primary controller (12). The primary controller (12) wirelessly communicates position directives (e.g., a polymer introduction station position directive) to each carriage controller (45), which correspondingly provides operational position instructions to each carriage's respective propulsion system (30), so as to re-position at least one carriage. The primary controller also provides directives to other secondary controllers in the molding system, depending on the status of, and in particular the location of the various carriages within, the molding system. For example, with a carriage (15) positioned in the polymer introduction station (18), the primary controller (12) communicates one or more polymer introduction directives to a polymer introduction controller (68), which then provides operational polymer introduction instructions to a polymer introduction apparatus (71), such as an extruder, thus resulting in the introduction of a polymer composition into contact with the interior mold surface (27) of the mold (24), and accordingly formation of a molded article.
US08535581B2 Induction furnace for melting of metals, lining for an induction furnace and method for production of such lining
The present invention relates to an induction furnace for melting of metals that do not connect inductively in solid state. The induction furnace has a lining comprising a mixture of graphite and silicon carbide and has an electric conductivity higher than the electrical conductivity of the metal to be melted when metal is in solid state, but lower than the electrical conductivity of the metal to be melted when the metal is in molten state. The invention further relates to a lining for induction furnace and to a method for producing such lining.
US08535580B2 Digitally forming a dental model for fabricating orthodontic laboratory appliances
The present invention provides a method that uses digital data, such as that obtained from an intraoral scanner, to fabricate a wide range of customized laboratory appliances. The digital data is used to form a negative mold, which is in turn used to make a physical dental model. The negative mold is configured such that it can be flexed, stretched, fractured or disassembled to release the physical dental model. The physical dental model is then used for fabricating an orthodontic laboratory appliance.
US08535578B2 Flame-retardant wood-based materials
The present invention relates to wood-base materials made flame-retardant with halogen-free organic phosphorus compounds, and to compositions and processes for their production and their use.
US08535576B2 High refractive index inorganic oxide nanoparticles comprising surface treatment and polymerizable resin
Inorganic nanoparticles having a refractive index of at least 1.60 wherein the nanoparticles are surface modified with a surface treatment comprising a compound comprising a carboxylic acid end group and a C3-C8 ester repeat unit.
US08535575B2 Current-voltage non-linear resistor and method of manufacture thereof
A current-voltage non-linear resistor (10) comprises a sintered body (20) of a mixture whose chief constituent is zinc oxide and including as auxiliary constituents at least bismuth (Bi), antimony (Sb), manganese (Mn), cobalt (Co) and nickel (Ni). Also, the average grain size of the mixture is no more than 0.4 μm; and the average grain size of the zinc oxide grains in the sintered body (20) is no more than 7.5 μm and the standard deviation based on the grain size distribution of zinc oxide grains in the sintered body (20) is no more than 15% of the average grain size of the zinc oxide grains.
US08535574B2 Transition metal complexes, manufacturing method thereof, photovoltaic cells and manufacturing method thereof
This invention provides a transition metal complex of formula MXY2Z and a manufacturing method thereof, wherein M is selected from iron, ruthenium, and osmium; X represents a ligand shown in formula (II) wherein R1 and R1′ are independently selected from COOH, PO3H2, PO4H2, SO3H2, SO4H2, and derivatives thereof; Y is selected from H2O, Cl, Br, CN, NCO, NCS, and NCSe; Z represents a bidentate ligand having at least two fluorinated chains. In addition, this invention also provides photovoltaic cells and a manufacturing method thereof.
US08535570B2 Process for the preparation of a conductive polymer composition
The present invention relates to a process for the preparation of a conductive polymer composition comprising the steps of A) providing a latex containing a conductive polymer; B) mixing the latex from A with either an aqueous latex of a polymer, or with (a) water-soluble precursor(s) of a polymer; C) removing water from the so obtained mixture; D) heating the product from step C) to a temperature at which the polymer added in step B flows or where the polymer introduced in step B is formed from out of its precursor(s); and E) processing and/or solidifying the product of step D) into a desired form, wherein the amount of conductive polymer is between 0.1 and 10 wt % relative to the total of the total of components in step A and B. In step A optionally carbon nanotubes (CNTs) in an aqueous medium are preferably added to the latex containing conductive polymer. In that case the conductive polymer may behave as a conductive polymeric surfactant for the CNTs dispersed in water.
US08535569B2 Corrosion inhibitor compositions comprising tetrahydrobenzotriazoles and other triazoles and methods for using same
A composition with a corrosion inhibitor component having one or more tetrahydrobenzotriazoles and one or more other triazoles; wherein the tetrahydrobenzotriazoles are in a weight ratio to the other triazoles such that the composition decreases the General Corrosion rate, as measured by copper electrodes in the presence of 10 ppm sodium hypochlorite, by at least about 0.05 mpy relative to a corrosion inhibitor component which is 100% of the other triazoles. Also, a method of using this composition to inhibit corrosion of a metal component which has a metal or metal alloy which is corrodible in the presence of copper or copper corroding agents.
US08535568B2 Corrosion inhibitor compositions comprising tetrahydrobenzotriazoles solubilized in activating solvents and methods for using same
A composition with one or more tetrahydrobenzotriazoles and one or more one or more tetrahydrobenzotriazole activating solvents, wherein the tetrahydrobenzotriazoles are solubilized in the activating solvents in an amount effective to inhibit corrosion of a metal or metal alloy which is corrodible in the presence of copper or copper corroding agents. Also, a method of using this composition to inhibit corrosion of a metal component which has a metal or metal alloy which is corrodible in the presence of copper or copper corroding agents.
US08535561B2 Tail seals
Tail seal compound (tail seal) for tunnelling machine comprising blown oils, more than 30% by weight of a mineral charge and fibrous material.
US08535559B2 Nitrogen-containing fluoroketones for high temperature heat transfer
Nitrogen-containing fluorochemical ketones are provided that can be useful in apparatuses that includes a device and a mechanism for transferring heat. The provided fluorochemical ketones are stable at temperatures above 170° C., are environmentally friendly, and are economical to produce. The provided apparatuses can be useful for vapor phase soldering of electronic devices.
US08535557B2 Compositions and methods for reducing fire hazard of flammable refrigerants
The present invention relates to compositions comprising flammable refrigerant, fire hazard-reducing agent, and optionally a lubricant suitable for use in a refrigeration or air conditioning apparatus. Further, the present invention relates to compositions comprising lubricant and fire hazard-reducing agent and methods for reducing flammability of flammable refrigerant, for delivering a fire hazard-reducing agent to a refrigeration or air conditioning apparatus, and for replacing a non-flammable refrigerant with a flammable refrigerant.
US08535555B2 Epoxide and fluorinated epoxide stabilizers for fluoroolefins
The present invention relates to compositions comprising at least one fluoroolefin and an effective amount of stabilizer that may be an epoxide, fluorinated epoxide or oxetane, or a mixture thereof with other stabilizers. The stabilized compositions may be useful in cooling apparatus, such as refrigeration, air-conditioning, chillers, and heat pumps, as well as in applications as foam blowing agents, solvents, aerosol propellants, fire extinguishants, and sterilants.
US08535553B2 Large-area single- and few-layer graphene on arbitrary substrates
A film of single-layer to few-layer graphene is formed by depositing a graphene film via chemical vapor deposition on a surface of a growth substrate. The surface on which the graphene is deposited can be a polycrystalline nickel film, which is deposited by evaporation on a SiO2/Si substrate. A protective support layer is then coated on the graphene film to provide support for the graphene film and to maintain its integrity when it is removed from the growth substrate. The surface of the growth substrate is then etched to release the graphene film and the protective support layer from the growth substrate, wherein the protective support layer maintains the integrity of the graphene film during and after its release from the growth substrate. After being released from the growth substrate, the graphene film and protective support layer can be applied onto an arbitrary target substrate for evaluation or use in any of a wide variety of applications.
US08535552B2 Method of evaluating center segregation of continuous cast slab
A method for evaluating center segregation of a continuous cast slab is provided. The method of the present invention includes (A) creating a center segregation image of a slab using an etching solution comprising a picric acid (C6H3N3O7), a cupric chloride (CuCl2), sodium laurylbenzenesulfonate (C18H29SO3Na) and the remainder of distilled water; and (B) evaluating the center segregation of a slab by scanning the image and applying the following Formula. The method creates an image of center segregation even for low-carbon steel having carbon (C) in an amount of 0.04 wt % or less as well as ultra low-sulfur steel having sulfur (S) in an amount of 50 ppm or less.
US08535549B2 Method for forming stair-step structures
A method for forming a stair-step structure in a substrate is provided. An organic mask is formed over the substrate. A hardmask with a top layer and sidewall layer is formed over the organic mask. The sidewall layer of the hard mask is removed while leaving the top layer of the hardmask. The organic mask is trimmed. The hardmask is removed. The substrate is etched. The forming the hardmask, removing the sidewall layer, trimming the organic mask, and etching the substrate are repeated a plurality of times.
US08535545B2 Method for fabricating pellicle of EUV mask
A method for fabricating a pellicle of an EUV mask is provided. An insulation layer is formed over a silicon substrate, and a mesh is formed over the insulation layer. A frame exposing a rear surface of the insulation layer is formed by selectively removing a center portion of a rear surface of the silicon substrate. A membrane layer is deposited over the mesh and an exposed top surface of the insulation layer which is adjacent to the mesh. A rear surface of the membrane layer is exposed by selectively removing the portion of the insulation layer which is exposed by the frame.
US08535544B2 Structure and method to form nanopore
A method of fabricating a material having nanoscale pores is provided. In one embodiment, the method of fabricating a material having nanoscale pores may include providing a single crystal semiconductor. The single crystal semiconductor layer is then patterned to provide an array of exposed portions of the single crystal semiconductor layer having a width that is equal to the minimum lithographic dimension. The array of exposed portion of the single crystal semiconductor layer is then etched using an etch chemistry having a selectivity for a first crystal plane to a second crystal plane of 100% or greater. The etch process forms single or an array of trapezoid shaped pores, each of the trapezoid shaped pores having a base that with a second width that is less than the minimum lithographic dimension.
US08535543B2 Separation of particulate matter and animal manure
The present invention relates to separating one or more of sand and other particulate matter from a mixture of animal waste and water. The present invention can help to control the discharge of noxious odors while processing material containing animal waste. An exemplary apparatus in accordance with the present invention includes a cylindrical housing and a non-rotating collection table. An exemplary apparatus in accordance with the present invention includes optional shield provided inside the cylindrical housing that can help to capture the particulate matter and that can also help to reduce the discharge of noxious gas and odors from the apparatus.
US08535542B2 Filter press with integrated radio frequency heating
A method of separating a mixture of liquid and insoluble solids in a filter press may comprise: pumping the mixture into a chamber between two filter plates in the filter press to form a filter cake, wherein the chamber is lined by filter cloths, and wherein, during the pumping, filtrate is forced through the filter cloths and out of the chamber; heating the filter cake in the chamber, wherein, during the heating, filtrate is forced through the filter cloths and out of the chamber, and wherein the heating is by radio frequency irradiation of the filter cake in the chamber; and releasing dried filter cake from the chamber. A filter press system for separating a mixture of liquid and insoluble solids may comprise: a frame; a plurality of filter plates configured to form a stack of parallel plates, each of the plurality of filter plates being movably attached to the frame, the plurality of filter plates further being configured to form a multiplicity of chambers, each of the multiplicity of chambers being lined by filter cloths, wherein the plurality of filter plates, the multiplicity of chambers and the filter cloths are configured to allow filtrate to escape from the chambers while retaining solids from the mixture to form a filter cake; and a radio frequency heater, for directly heating the filter cake in the multiplicity of chambers. The radio frequency heating may include microwave heating, or dielectric heating by lower frequency radio waves in the range of 1 to 100 MHz.
US08535541B2 Method for separating immunomagnetic bead labeled particulates
Disclosed is a method for separating immunomagnetic bead labeled particulates. A carrier board is formed with at least one flow channel structure, which includes an inner reservoir, an outer reservoir, and at least one micro flow channel in communication with the inner reservoir and the outer reservoir. The method includes labeling target particulates with immunomagnetic bead, introducing a sample fluid into the inner reservoir, and applying a magnetic force and a driving force, wherein the driving force drives the particulates not labeled with immunomagnetic bead to flow through the micro flow channel to the outer reservoir, while the magnetic force attracts the particulates labeled with the immunomagnetic bead to retain in the inner reservoir. The driving force may be centrifugal force, pressure, or surface tension.
US08535535B2 Use of hydrophobin as a phase stabilizer
Hydrophobins for stabilizing phases in biphasic liquid systems.
US08535526B2 Method and device for biogenic waste treatment
The present discloses a method and a device for biogenic waste, or bio-waste treatment, and said method is as follows: Firstly, the biogenic waste is evenly mixed with water vapor, or steam, heating and pressurizing so that the temperature reaches 130-190° C. and the pressure reaches 1.5-1.9 MPa after mixture, and this state is maintained for 1-25 minutes; Then, the pressure of the mixture of said biogenic waste and water vapor is reduced to normal pressure, such as atmospheric pressure so as to conduct low-molecularization, such as decreasing or reduction of molecular weight of the biogenic waste to obtain a low-molecularized mixture, such as a low molecular weight mixture; finally, the low-molecularized mixture, such as low-molecular weight mixture is separated so as to obtain the final products. Said device includes reaction vessel, stirring device, vapor input device, pressure-reducing regulator and separation device.
US08535524B2 Exchangeable media filter
A filter element for a pool or spa including a sintered plastic outer cylinder of a first diameter, a sintered plastic inner cylinder of a second diameter less than said first diameter; the inner cylinder being position coaxially with respect to the outer cylinder to define an annular interior chamber; and a selected granulated filter medium or combination of media residing in the annular interior chamber.
US08535522B2 System and method for detection of disconnection in an extracorporeal blood circuit
The present invention is directed to a dialysis system with a disconnection monitor for determining if a blood line connection to a patient has been disconnected. It includes a blood circuit in fluid communication with a patient and a dialysis circuit, a pressure transducer for generating a signal indicative of a pulse signal in the blood circuit, a cardiac reference signal generator for generating a signal indicative of the patient's pulse and a disconnection monitor. The disconnection monitor includes a pressure transducer data receiver for receiving the signal indicative of the pulse signal in the blood circuit, a cardiac reference signal receiver for receiving the signal indicative of the patient's pulse, and a processor for cross-correlating the signal indicative of the pulse signal in the blood circuit and the signal indicative of the patient's pulse to generate data indicative of a disconnection of the blood line connection to the patient.
US08535519B2 Filter element and fuel filter
The invention concerns a filter element (1), in particular of a fuel filter for motor vehicles. The filter element (1) is provided for exchangeable use in a filter housing (2) and comprises a filter body (3) with a filter material (5) that is arranged in folds (4). Between two folds (4) a heating element (6) for the fuel is arranged.
US08535517B2 Method for treating waste petroleum
The present invention relates to a method for treating various waste petroleum into eco-friendly solid so that leaching of oil would not occur. The method of the present invention can treat radioactive waste petroleum as well as various waste petroleum, thereby stabilizing waste petroleum chemically and physically, wherein the method comprises mixing waste petroleum with a sulfuric acid and a nitric acid; adding sodium hydroxide, thereby carrying out a polymerization reaction to produce solid particles; colloidizing a mixture obtained by uniformly stirring the solid particles; adding a diisocyanate compound in reactor, thereby carrying out a subsequent polymerization reaction to obtain a new compound in the form of powder; discharging a generated gas into the atmosphere; and filling the powder into a resin as a filling material and compression molding and reclaiming the filled powder.
US08535516B2 Efficient method for improved coker gas oil quality
An efficient delayed coking process improvement for producing heavy coker gas oil of sufficient quality to be used as hydrocracker feedstock.
US08535511B2 Methods for electrochemical analysis using matrix compositions with alkylphenazine quaternary salt and a nitrosoaniline
A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.
US08535510B2 Method for measuring substrate concentration and apparatus for measuring substrate concentration
This invention provides a substrate concentration measuring method for measuring a concentration of a substrate included in a specimen based on an output for measurement from an enzyme electrode when the enzyme electrode and the substrate are reacted with each other, the substrate concentration is calculated using an output for correction from the enzyme electrode obtained when a reference solution whose substrate concentration is known and the enzyme electrode are reacted with each other before or after the enzyme electrode and the substrate are reacted with each other. For example, the output for correction is measured by each specimen. In this method, the substrate concentration may be calculated using the output for correction for the specimen to be measured and an output for correction corresponding to the at least one other specimen and measured prior to the output for correction.
US08535508B2 Coating method for forming pattern on workpiece
A coating method for forming a pattern on a workpiece is provided. First, a workpiece surface is provided. Second, a mask having a shape conforming to a predetermined pattern is provided. Next, the workpiece surface includes a first portion exposed outside and a second portion shielded by the mask. A shielding layer is formed on the exposed first portion of the workpiece surface. The mask is removed from the workpiece to expose the second portion. A coating layer over the shielding layer and the exposed second portion is formed. The coating layer consists of a first part overlaying the shielding layer and a second part overlaying the second portion. The mask is attached onto the coating layer and aligned with the second portion of the workpiece surface. The first part of the coating layer, the shielding layer, and the mask are then removed.
US08535506B2 Method for synthesizing metal oxide nanocyrstals
Method for synthesizing metal oxide nanocrystals. The method includes forming a precursor solution including the metal oxide cation and introducing a selected metal oxide binding virus into the solution. Electrical pulses are generated across the solution whereby highly crystalline nanowires are formed.
US08535505B2 Method for making metallic cover
A method for making a metallic cover including the following steps. Drawing an aluminum alloy sheet that has a yield strength in a range from about 80 MPa to about 150 MPa, an elongation ratio in a range from about 15% to about 28%, and a hardness in a range from about 45 HV0.2 to about 70 HV0.2 to form a preformed cover. The preformed cover includes a bottom base and a plurality of side walls, and each of the side wall and the bottom base are connected by a curved-cornered edge. Pressing the curved-cornered edge of the preformed cover into a sharp-cornered edge structure by a forming die. Polishing the preformed cover. Anodizing the polished preformed cover to form the metallic cover.
US08535502B2 System and method for recovery of CO2 by aqueous carbonate flue gas capture and high efficiency bipolar membrane electrodialysis
A system and method for recovery of CO2 includes an aqueous capture device having a capture solution. The aqueous capture device is arranged to receive gas and to capture components from the gas including at least CO2. An electrodialysis unit in operative connection with the capture device performs an electrodialysis operation on the capture solution including at least the CO2, wherein a CO2 rich process stream and a regenerated capture solution are generated from the capture solution including at least the CO2. The CO2 rich process stream is a pressurized process stream at a pressure which maintains the CO2 substantially within the CO2 rich process stream, while in the electrodialysis unit. In another alternative, at least the pH of the capture stream is controlled.
US08535498B2 Electrochemical gas sensor and method for clamping the same
An electrochemical gas sensor includes: a disc-shaped metal bottom member; a cylindrical metal side member that extends along the axial direction of the bottom member to surround the bottom member; a ring-shaped polymer gasket that includes an opening in the center and in which both sides of the opening each have an L-shaped member in cross section, with one section of the L-shaped member being in contact with the inner side of the side member and the other section of the L-shaped member being in contact with the bottom member; a gas sensor body that is located in the opening of the gasket and whose bottom surface is in contact with the bottom member and that includes a pair of electrodes and a solid electrolyte membrane or a separator retaining a liquid electrolyte; and a metal cover that is in contact with the top surface of the gas sensor body.
US08535496B2 Sputter-coating apparatus
A sputter-coating apparatus is configured for forming coatings on a plurality of workpieces, and includes a deposition chamber defining a cavity, a plurality of targets received in the cavity, and a plurality of supporting assemblies. Each target includes a first target plate and an opposite second target plate. The supporting assemblies are received in the cavity and arranged between the first target plates and the second target plates. Each supporting assembly includes a hollow rotating post for rotating about a first axis substantially parallel to a lengthwise direction thereof, at least one support extending from the post, and at least one driving unit. Each support includes a connecting arm rotatably connected to the post and a fixing portion attached to the connecting arm for supporting a workpiece. The driving unit is configured for driving each connecting arm to rotate relative to the corresponding post about a second axis.
US08535491B2 Electrochemical machining assembly with curved electrode
An electrode for an electrochemical machining process is provided. The electrode comprises a curved, electrically conductive member, and an insulating coating covering at least a portion of a side surface of the curved, electrically conductive member. An electrochemical machining assembly is also provided for machining curved holes in a workpiece. The assembly includes at least one curved electrode and a power supply operatively connected to provide a pulsed voltage to the at least one curved electrode and to the workpiece. The assembly further includes a rotational driver operatively connected to move the at least one curved electrode along a curved path within the workpiece. The assembly is configured to remove material from the workpiece upon application of the pulsed voltage to the at least one curved electrode and to the workpiece. An electrochemical machining method is also provided for forming one or more curved holes in an electrically conductive workpiece.
US08535485B2 Apparatus and process for wet crushing oil sand
A system for forming an oil sand slurry from mined oil sand is provided, comprising a slurry preparation tower having an intake opening through which oil sand enters the slurry preparation tower, a first sizer device to comminute the oil sand passing through it, a second sizer device to further comminute the oil sand, and a pump box for receiving oil sand that has passed through the second sizer and feeding it to a pump; at least one conveyor, having a discharge end, for transporting mined oil sand to the slurry preparation tower; a metal detector for detecting a piece of metal in the mined oil sand and transmitting a signal; and a metal rejection device operative to, in response to the signal from the metal detector, reject a portion of oil sand containing the piece of metal before the portion of oil sand enters the slurry preparation tower.
US08535478B2 Adhesive silicone elastomer composition
The present invention relates to a high-performance silicone elastomer composition that is adhesive and that can be crosslinked at high temperature for the assembly of silicone-based substrates, both by platinum and peroxide catalysis, and that may lend itself to a strip conformation. The composition comprises at least one gum, one catalyst and one adhesion promoter of polyorganohydrogensiloxane type, the nature and the amount of said adhesion promoter having been chosen so that Si—H groups are in excess following the reaction for crosslinking the composition, so as to obtain a potential surface density of covalent Si— bonds with the silicone substrate to be bonded of at least one covalent Si— bond per 60 nm2.
US08535476B2 Heat bonding polyurethane foams
A process for producing a laminate or composite structure comprises heat bonding a substrate to a polyurethane foam, wherein the polyurethane foam is produced using at least one natural oil derived polyol as at least a portion of the polyol used in making the polyurethane foam. The resulting laminate or composite structure comprises at least one foam produced from a polyol composition comprising at least one natural oil derived polyol and at least one substrate with the interface between the foam and substrate being that formed by heat bonding. The invention also includes any article comprising such a laminate or composite structure.
US08535475B2 Method for continuously attaching a primary substrate to a secondary substrate to form a product having indicia thereon
In one embodiment, a method of attaching one substrate to another substrate includes supplying a first substrate having an indicium thereon from a first source, supplying a second substrate from a second source, wherein the supplying is accomplished in a continuous manner, and curing the substrates until the substrates are bonded thereto to form a product. The method disclosed herein allows a fabric to be integrally bonded to either an elastomeric composition or a urethane composition utilizing a continuous process. The product includes indicium that identifies or conveys information about the product.
US08535474B2 Liquid applicator
A liquid applicator having a discharge roller (3) that discharges a liquid fed from feeding means in a prescribed pattern. The liquid discharged from the discharge roller (3) is applied to a moving substrate (S). The discharge roller (3) includes a surface plate (31) and a roller main body (32). The roller main body (32) has on its peripheral portion a recess (33) of prescribed shape, in which a liquid is introduced through the inside of the roller main body (32) and spread along the surface of the surface plate (31). The surface plate (31) has, in its portion covering the recess (33), a liquid exit part (3b) that permits exit of the liquid in a pattern different from the opening shape of the recess (33) and a liquid block part (3c) that blocks passage of a liquid. The liquid exit part (3b) is formed of a porous material having a large number of fine pores.
US08535473B2 Thermosettable adhesive tape, articles and methods
A thermosettable pressure sensitive adhesive tape comprising at least first and second adhesive layers bonded together. Each of the adhesive layers comprises a thermosettable pressure sensitive adhesive, which is the photo-polymerization reaction product of starting materials. The starting materials for each adhesive layer comprises at least a photo-polymerizable acrylic component and a thermosettable epoxy component. The thermosettable pressure sensitive adhesive, used for either of the two adhesive layers, is not black when fully cured without the presence of a black coloring pigment. The first adhesive layer is made from a layer of starting materials that is thin enough to allow substantial photo-polymerization of the starting materials, even with the starting materials containing a sufficient amount of a black coloring pigment to cause the first adhesive to have a black color after the first adhesive is substantially cured. The second adhesive layer is made from a layer of starting materials which has a thickness that would be sufficiently thick to prevent substantial photo-polymerization (e.g., with UV light) of the starting materials, if the starting materials contained enough of a black coloring pigment to cause the second adhesive to have a black color after the second adhesive is cured.
US08535472B2 Laser-welded article
A method of manufacturing laser-welded article having an integral construction of piled workpieces, that are welded by heat generated from irradiation with laser and include thermoplastic resin, a laser-transmissible-absorptive molded workpiece including a thermoplastic resin and 0.001 to 0.3 weight % of colorant consisting of nigrosine which has an absorption coefficient: ε for a ray of 940 nm ranging form 4000 to 7000, that transmits laser partially and absorbs laser partially, and a laser-absorptive molded workpiece including a thermoplastic resin and 0.1 to 5 weight % of diverse colorant comprising nigrosine and/or carbon black, that absorbs the laser.
US08535471B2 Door skin, a method of etching a plate, and an etched plate formed therefrom
The present invention relates to a door skin comprising an exterior surface having outer portions lying on a first plane, spaced grooves recessed from the plane of the outer portions, and tonal portions having a planar area and a plurality of spaced depressions recessed from the plane of said planar area. The present invention is also directed to a method of etching a plate, for use with a molded die set, for embossing a wood grain pattern in the door skin, and the etched plate formed therefrom.
US08535470B2 Mold for shaping baseball or softball
A mold for shaping a baseball or softball is constructed from two identical figure of 8 shaped mold pieces which correspond to an outside shape of a ball. The two mold pieces are made from flexible materials such as rubber, silicone or plastic resin, fit onto each other to form the outside shape of the ball. Joining areas of the two mold pieces have joining edges, and on inside sides of the joining edges on interior surfaces of the two mold pieces grooves are set which form a raised sewn section on a surface of the ball cover, and a material inlet and air outlet are formed where the two mold pieces join.
US08535466B2 Process for making fibrous structures comprising a polymer structure
Polymer structures and methods for making such polymer structures are provided. More particularly, polymer structures comprising a hydroxyl polymer structure, such as a fiber comprising a hydroxyl polymer are provided. Even more particularly, fibrous structures comprising a hydroxyl polymer structure, such as a fiber comprising a hydroxyl polymer, wherein the fibrous structure exhibits a CETM Factor of less than 20 and/or a CETM*L2 Factor of less than 950 are provided.
US08535462B2 Method for producing spring rails for windshield wipers
The invention relates to a method for producing coated spring-loaded steel rails especially for windshield wipers comprising a rubber or elastomer wiper blade, wherein a cold-rolled steel rail blank is provided with a zinc layer, whereafter a zinc-containing anchor layer is produced, and a coating made of a polymerizable coating powder is deposited on the anchor layer and partially cured.
US08535460B2 Low Co hydrogen storage alloy
A hydrogen storage alloy is provided which has an extremely low Co content, and can maintain the drain (power) performance (especially pulse discharge characteristics), activity (degree of activity), and life performance at high levels. The hydrogen storage alloy is manufactured by weighing and mixing every material for the hydrogen storage alloy so as to provide an alloy composition represented by the general formula MmNiaMnbAlcCod or MmNiaMnbAlcCodFee, and controlling the manufacturing method and manufacturing conditions so that both the a-axis length and the c-axis length of the crystal lattice are in a predetermined range. Although it is sufficient if the a-axis length of the crystal lattice is 499 pm or more and the c-axis length is 405 pm or more, by further specifying the a-axis length and c-axis length depending on the values of ABx, a hydrogen storage alloy having high durability can be provided.
US08535457B2 Rolling member, rolling bearing and process for manufacturing rolling member
The invention provides a deep groove ball bearing which exhibits a long life even in a high-temperature environment or an environment involving the penetration of water in spite of its low alloying element content. The outer race, inner race and ball constituting the bearing are made of a steel which contains 0.3 to 0.4% of carbon, 0.3 to 0.7% of silicon, 0.3 to 0.8% of manganese, 0.5 to 1.2% of nickel, 1.6 to 2.5% of chromium, 0.1 to 0.7% of molybdenum and 0.2 to 0.4 of vanadium with the balance consisting of iron and impurities and in a total content of silicon and manganese of 1.0% or below, a total content of nickel and chromium of 2.3% or above and a total content of chromium, molybdenum and vanadium of 3.0% or below. Surface hardened layers are formed in the outer race, inner race and ball respectively and the surface hardened layers exhibit hardness of 725 to 800 HV, while the maximum particle size of carbides dispersed in the surface hardened layers is 10 μm or below and the area ratio thereof is 7 to 25%. Further, the inner parts exhibit hardness of 450 to 650 HV.
US08535456B2 Chemical conversion treatment solution for a steel material and chemical conversion treatment method
A chemical conversion treatment solution for a steel material is provided. The solution is an acidic aqueous solution of pH 3 to 5 containing 50 to 500 ppm by weight of zirconium fluoride complex in terms of Zr, 5 to 50 ppm by weight of free fluorine, and 5 to 30% by weight in relation to Zr of polyethyleneimine having a weight average molecular weight of 300 to 10,000, a molar ratio of the primary amino group of at least 30%, and a molar ratio of the tertiary amino group of at least 15% in relation to the total amino group content. A method for chemical conversion treatment is also provided. This invention realizes excellent coating adhesion and corrosion resistance after the coating, as well as improved throwing power in the coating, and in particular, in the electrodeposition coating of a steel material.
US08535453B1 Automated pipe clearing apparatus
An automated pipe clearing apparatus for extracting matter contained within a drain pipe. The drain pipe clearing apparatus contains a vacuum pump having an inlet port and a discharge port. The inlet port is fluidly coupled to the drain pipe. A control module is in electrical communication with an electrical power source and the vacuum pump. The control module is programmed to actuate the vacuum pump at a predetermined time for a predetermined duration. The vacuum pump produces a suction to clear the drain pipe. The removed matter exits the vacuum pump through the discharge port. When the vacuum pump is not operating, gravity causes the drain pipe to continue normal draining.
US08535451B2 Method and apparatus for cleaning semiconductor wafers using compressed and/or pressurized foams, bubbles, and/or liquids
An apparatus and method are disclosed in which a semiconductor substrate having a surface containing contaminants is cleaned or otherwise subjected to chemical treatment using a foam. The semiconductor wafer is supported either on a stiff support (or a layer of foam) and foam is provided on the opposite surface of the semiconductor wafer while the semiconductor wafer is supported. The foam contacting the semiconductor wafer is pressurized using a form to produce a jammed foam. Relative movement between the form and the semiconductor wafer. such as oscillation parallel and/or perpendicular to the top surface of the semiconductor wafer. is then induced while the jammed foam is in contact with the semiconductor wafer to remove the undesired contaminants and/or otherwise chemically treat the surface of the semiconductor wafer using the foam.
US08535450B2 Formulations, their use as or for producing dishwashing compositions and their preparation
Formulations comprising (A) at least one compound selected from aminocarboxylates and polyaminocarboxylates, and salts and derivatives thereof, (B) at least one salt of bismuth, and (C) at least one homopolymer or copolymer of ethyleneimine.
US08535449B2 Use of coke compositions for on-line gas turbine cleaning
A method is disclosed for removing deposits from rotating parts of a gas turbine engine while under full fire or idle speed utilizing a particulate coke composition. The coke composition may be introduced directly into the combustion chamber (combustor) of the gas turbine or, alternatively, anywhere in the fuel stream, water washing system, or the combustion air system. By kinetic impact with the deposits on blades and vanes, the deposits will be dislodged and will thereby restore the gas turbine to rated power output. If introduced into the compressor section, the coke particles impinge on those metal surfaces, cleaning them prior to entering the hot gas section where the process is repeated.
US08535447B2 Method and system to stabilize and preserve ion artifacts
A method, system and device to use a dilute alkaline solution held at sub-critical temperature and pressure conditions to remove rapidly chloride ions from corroded iron artifacts.
US08535444B2 Substrate processing apparatus, method of manufacturing semiconductor device, and ceiling insulating part
Provided is a substrate processing apparatus. The substrate processing apparatus comprises a reaction vessel configured to process a substrate, and a heating device. The heating device comprises at least one sidewall insulating part surrounding the reaction vessel, a ceiling insulating part placed on the sidewall insulating part and comprising a plurality of stress relief grooves, and a heating element installed at an inner side of the sidewall insulating part.
US08535440B1 Method of promoting single crystal growth during melt growth of semiconductors
The method of the invention promotes single crystal growth during fabrication of melt growth semiconductors. A growth ampoule and its tip have a semiconductor source material placed therein. The growth ampoule is placed in a first thermal environment that raises the temperature of the semiconductor source material to its liquidus temperature. The growth ampoule is then transitioned to a second thermal environment that causes the semiconductor source material in the growth ampoule's tip to attain a temperature that is below the semiconductor source material's solidus temperature. The growth ampoule so-transitioned is then mechanically perturbed to induce single crystal growth at the growth ampoule's tip.
US08535437B2 Pumpable geopolymers comprising a fluid-loss agent
The invention concerns the use of a fluid loss control additive in a pumpable geopolymeric suspension for oil and/or gas industry applications, said suspension further comprising an aluminosilicate source, a carrier fluid, and an activator, and method of providing such a suspension in a borehole. In particular, the suspension according to the invention is used for well primary cementing operations and/or remedial applications.
US08535434B2 Material in the form of lithium fluoride powder containing colour centres, method for preparation and use thereof
It is describes a material in the form of lithium fluoride powder containing color centers and the method for its preparation, by the formation of color centers based on irradiating the powder with synchrotron radiation (light). The method involves mechanically reducing the size of the particles that form the LiF powder and the formation of color centers therein by its exposure to synchrotron radiation. The so activated powder, which maintains the transparency characteristics of the original material if exposed to sunlight, can find wide use as an additive both in common printing inks and in pigments used in the artistic field to be used for the formation of marks on artifacts for anti-counterfeiting/identification purposes.
US08535431B2 Porphyrazine coloring matter, ink composition containing the same and colored product
The present invention relates to a porphyrazine coloring matter or a salt thereof represented by the following formula (1): [wherein, the rings A to D are independently a benzene ring or a nitrogen-containing heteroaromatic ring, the number of the nitrogen-containing heteroaromatic ring is more than 0.00 and less than 1.00 as an average value, the rest are benzene rings, E is alkylene, X and Y are a sulfo-substituted anilino group and the like, b is 0.00 or more and less than 3.90 as an average value, c is 0.10 or more and less than 4.00 as an average value, and the sum of b and c is more than 3.00 and less than 4.00 as an average value]. The ink composition containing the porphyrazine coloring matter of the present invention or a salt thereof is an ink composition which has a hue closer to the standard color as a cyan ink, is excellent in various fastnesses, particularly in ozone fastness, and can provide recorded images having a high print density and thus having a good balance, and further it is suitable for inkjet recording.
US08535429B2 Caustic scrubber system and method for biogas treatment
The present invention provides a method and apparatus for the treat en of process gas from an anaerobic digestion system or a landfill gas system. In one embodiment, the system comprises a caustic scrubber including a vertical column having a top and a bottom and including a counter current flow system, wherein a process gas stream flows up vertically through the column in counter current flow to a caustic liquid solution that flows downward through the column. The caustic liquid solution removes at least one acid from the process gas stream, wherein treated gas that is substantially free of acids bubbles out through an opening at the top of the vertical column.
US08535421B2 Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities
A blood storage system. The system has a collection bag for red blood cells; an oxygen/carbon dioxide depletion device; a storage bag for red blood cells; and tubing connecting the collection bag to the depletion device and the depletion device to the storage bag. The depletion device includes a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas; a plurality of hollow fibers or gas-permeable films extending within the receptacle from an entrance to an exit thereof. The hollow fibers or gas-permeable films are adapted to receiving and conveying red blood cells.
US08535415B2 Refinery gas upgrading via partial condensation and PSA
A process and system for recovering valuable by-products (e.g., hydrogen) from refinery gas streams. For hydrogen-only recovery, the invention comprises a partial condensation step to upgrade the refinery fuel gas to a minimum of 60% hydrogen, which is further purified in a pressure swing adsorption process. When configured to recover hydrogen, methane-rich gas and raw LPG (methane depleted gas containing C2 hydrocarbons and heavier), the invention comprises two partial condensation steps where the feed is cooled in the first step to allow separation of ethane and heavier hydrocarbons, and the resulting vapor is cooled to a lower temperature in a second step for hydrogen recovery.
US08535414B2 Recovering of xenon by adsorption process
The present invention discloses the improvements to a vacuum swing adsorption (VSA) process used for Xe recovery. By only collecting the recovered gas mixture after the initial evacuation of N2 from the adsorbent vessel and void space, the recovered Xe is not diluted by N2 contained in the adsorbent vessel and void space. The concentration of the recovered Xe can by increased (high purity), simultaneously little Xenon is lost. During the initial evacuation of N2, the vessel has been evacuated to a pressure less than 1 atmospheric pressure, for example, from 100 to 1 torr.
US08535413B2 Integrated mechanical vapor recompression (MVR) and membrane vapor permeation process for ethanol recovery (ethanol dehydration) from fermentation broth
An apparatus and process is taught for the formation of ethanol from a fermentation medium in the absence of an ethanol concentration distillation step.
US08535412B2 Oxygen concentration system and method
The present system is an adsorption system for separating air into a concentrated gas component, which has an air supply, a compressor for receiving and compressing the air supply, providing a compressed air supply, and molecular sieve material for separating the compressed air supply into a concentrated gas component. The adsorption system delivers at least 5 liters per minute (LPM) of concentrated gas component from the molecular sieve material in which the system has a specific total weight per LPM <9 lbs/LPM. Additionally, an output quantity of the concentrated gas is delivered by the adsorption system and a purging quantity of the concentrated gas is dispensed into a sieve chamber of the adsorption system undergoing a purge cycle. The purging quantity has a value equal to or less than the difference between the maximum quantity and the output quantity, and the purging quantity is controlled based on the output quantity.
US08535411B2 Production of iron from metallurgical waste
A method of recovering metallic iron from iron-bearing metallurgical waste in steelmaking comprising steps of providing an iron-bearing metallurgical waste containing more than 55% by weight FeO and FeO equivalent and a particle size of at least 80% less than 10 mesh, mixing the iron-bearing metallurgical waste with a carbonaceous material to form a reducible mixture where the carbonaceous material is between 80 and 110% of the stoichiometric amount needed to reduce the iron-bearing waste to metallic iron, and as needed additions to provide a silica content between 0.8 and 8% by weight and a ratio of CaO/SiO2 between 1.4 and 1.8, forming agglomerates of the reducible mixture over a hearth material layer to protect the hearth, heating the agglomerates to a higher temperature above the melting point of iron to form nodules of metallic iron and slag material from the agglomerates by melting.
US08535409B2 Control method for melting a metal charge and weighing device used in said method
A control method for melting a metal charge in a furnace comprising at least a hearth containing the metal charge and a roof. The method provides that the hearth is weighed by means of a plurality of weighing elements distributed along the perimeter of the base of the hearth, and that the values detected by the plurality of weighing elements are sent to a control unit in order to obtain information relating to the distribution of the metal charge inside the hearth.
US08535408B2 High thermal conductivity hardfacing
A hardmetal composition comprises tungsten carbide in an amount greater than 50 weight percent of the hardmetal composition. In addition, the hardmetal composition comprises a binder material consisting of at least 90 weight percent nickel, a binder flux between 3.5 to 10.0 weight percent chosen from the group consisting of boron and silicon, and less than 1.0 weight percent other components.
US08535403B2 Filter assembly with mounting
A filter assembly, including an air cleaner assembly for an internal combustion engine in an underhood engine compartment, includes a mounting bracket with a flow passage therethrough. In one form, a combination air filter element and base is provided for an air cleaner assembly. In a further form, a filter assembly includes a filter element integrally and permanently mounted to the base for removal and replacement as a single unit.
US08535398B1 Chemical complexes comprising glycerine and monoglycerides for thickening purposes
The present invention is generally directed to systems and methods for thickening liquids, e.g., hydrophobic liquids, non-aqueous liquids, fuels, etc. In one set of embodiments, a composition is produced by combining in a mixture, at least one monoglyceride (abbreviated “MG”) and glycerine (abbreviated “G”), in which the molar ratio of G to MG in the mixture is between 1:1 and 4:1. The mixture may be melted and cooled to form solids containing a G2MG molecular complex in which two molecules of G are hydrogen-bonded to each molecule of MG. The composition may be substantially free, in certain embodiments, of contaminating reactants, catalysts, alkaline agents, and/or by-products of fatty acid interesterification that may interfere with the use of said composition as a thickening agent.
US08535396B2 Electrochemical apparatus with barrier layer protected substrate
The present invention relates to apparatus, compositions and methods of fabricating high performance thin-film batteries on metallic substrates, polymeric substrates, or doped or undoped silicon substrates by fabricating an appropriate barrier layer composed, for example, of barrier sublayers between the substrate and the battery part of the present invention thereby separating these two parts chemically during the entire battery fabrication process as well as during any operation and storage of the electrochemical apparatus during its entire lifetime. In a preferred embodiment of the present invention thin-film batteries fabricated onto a thin, flexible stainless steel foil substrate using an appropriate barrier layer that is composed of barrier sublayers have uncompromised electrochemical performance compared to thin-film batteries fabricated onto ceramic substrates when using a 700° C. post-deposition anneal process for a LiCoO2 positive cathode.
US08535391B2 Catalysed dye systems
The present invention is concerned with a dye system for application to a substrate, the dye system comprising: (a) at least one dye precursor; (b) an oxidizing agent; and (c) a catalyst, wherein the catalyst is a homogeneous catalyst or a heterogeneous catalyst. Preferably, the catalyst comprises at least one metal-containing compound. The invention also envisages a method for the coloration of a substrate, the method comprising treating the substrate with the dye system of the invention. In preferred embodiments of the invention, the substrate comprises human hair, natural or synthetic polymers, or textile fibers. In further preferred embodiments, the at least one dye precursor is an organic precursor, the at least one metal derivative for use as a catalyst comprises at least one inorganic metal compound or at least one metal complex comprising at least one organic ligand, and the oxidizing agent is hydrogen peroxide.
US08535386B2 Stem with pressfit porous element
An implant assembly comprises a stem and an augment. The augment includes a porous outer region which is integrally formed onto a solid inner region. The augment further includes, solid posts integrally formed on the solid inner region and extend through the porous outer region to the outer surface of the augment. The posts are integrally formed with and surrounded by the porous region and are designed to allow assembly of the augment to the stem without damaging the structure of the porous region. A method of attaching the augment is described, wherein a tool is designed to grip to posts of the augment and apply loads through these posts during assembly.
US08535384B2 Acetabular screw hole covers with porous coating
An acetabular shell can include a substrate and a screw hole cover. The substrate can define a screw hole configured to receive a screw to fix the substrate to bone. The screw hole cover is formed separate from the substrate and attached to the substrate to cover the screw hole, and configured to be ruptured.
US08535378B2 Vertebral interbody spacer
A spinal fusion interbody spacer device has a solid central core positioned between laterally opening opposed concave side surfaces. The device includes spaced apart superior and inferior abutment surfaces which are convexly arced. The spacer device is implanted between a pair of adjacent vertebrae by insertion in a tipped-over orientation and then reoriented to an upright orientation for engagement of the abutment surfaces by facing surfaces of the vertebrae.
US08535373B2 Minimally-invasive cardiac-valve prosthesis
A cardiac-valve prosthesis is adapted for percutaneous implantation. The prosthesis includes an armature adapted for deployment in a radially expanded implantation position, the armature including a support portion and an anchor portion, which are substantially axially coextensive with respect to one another. A set of leaflets is coupled to the support portion. The leaflets can be deployed with the armature in the implantation position. The leaflets define, in the implantation position, a flow duct that is selectably obstructable. The anchor portion can be deployed to enable anchorage of the cardiac-valve prosthesis at an implantation site.
US08535371B2 Method of positioning a tubular element in a blood vessel of a person
A method of positioning a tubular element inside a main blood vessel of a person. The tubular element has a main tube with one or more side openings and a transport wire extending through each side opening. A fixator being positioned in each branch vessel and the corresponding guide wire being attached to the corresponding transport wire, whereby re-routing of the guide wire is performed by pulling the transport wire to have the guide wire extend from the fixator through the corresponding side opening and to the outside of the person. This re-routed guide wire may be used for positioning the tubular element or guiding additional elements from the tubular element and into the branch vessel.
US08535369B2 Prosthesis deployment device with translucent distal end
A prosthesis delivery and deployment device includes an elongate and flexible outer catheter. The outer catheter has a tubular wall of layered construction, including translucent layers, opaque layers, and a braid composed of helically wound metal filaments. The outer catheter has a translucent distal adapted to constrain a radially self-expanding prosthesis in a radially reduced, axially elongated state. Because the stent constraining region is translucent, an endoscope can be used to visually monitor the stent when so constrained. Radiopaque markers can be mounted to the outer catheter and to an inner catheter used to deploy the prosthesis, to afford a combined visual and fluoroscopic monitoring for enhanced accuracy in positioning the prosthesis, both before and during its deployment.
US08535368B2 Apparatus for loading and delivering a stent
A stent loading and deployment device includes an outer elongate tubular member having opposed proximal and distal ends and an inner elongate tubular member having opposed proximal and distal ends and slidably disposed within the outer tubular member. When the distal ends of the outer tubular member and the inner tubular member are axially aligned, a stent deployment region is defined there in between. The device further includes a stent loading member having opposed proximal and distal ends and slidably disposed between the outer tubular member and the inner tubular member. The distal end of the stent loading member is slidable to a distal position past the distal end of the outer tubular member for receiving a stent and is further slidable toward the proximal end of the outer tubular member to a location past the stent deployment region for disengagement of a stent from the stent loading member.
US08535365B2 Moxa burning bowl
A moxa burning bowl is provided for application of heat treatment to body portions of a user, with the bowl having a flexible ring-shaped base member of a flexible cloth-like exterior and granular material therein, shaped in a ring-like or torus-like configuration, and having a generally concave shaped upper dish-like member and an open bottom, defining a zone therebetween when the bowl is placed on an exterior surface of a patient/user, for treatment. Moxa sticks or cones are carried by the dish-like member, projecting upwardly therefrom, and situated in sockets of the dish-like member, with the dish-like member having an upstanding periphery, enabling the dish-like member to catch fallen ash from burning moxa sticks or cones carried by the bowel.
US08535363B1 Facial heating pad device
A facial heating pad device provides a dry heating pad producing dry, hot heat and an opposed moist heating pad producing moist warm heat. The device includes a face pad, a power supply operationally coupled to the face pad, and a control unit. The control unit is operationally coupled to the face pad and the power supply for selectively providing power to heat the face pad. The face pad includes a dry heating portion operationally coupled to the control unit for selectively providing dry heat when the dry heating portion is heated by the power supply. The face pad also includes a moist heating portion operationally coupled to the control unit for selectively providing moist heat when the moist heating portion is heated by the power supply.
US08535352B2 Multi-level minimally invasive spinal stabilization system
A spinal alignment system for interconnecting vertebral bodies is disclosed. The system includes a bone screw polyaxially connected to a seat. The seat includes a top opening, a first rod receiving portion and a second rod receiving portion, a first rod channel and a second rod channel. The system is implanted into a first vertebral body. A first rod is introduced to the seat through the top opening in a first orientation and connected to the first rod receiving portion. A second rod is introduced to the seat through the top opening in a first orientation and connected to the second rod receiving portion. The first and second rods are each moved into a second orientation such that the rods project through the first and second rod channels, respectively. The rods are capable of polyaxial movement with respect to the seat for landing the opposite ends of the rods in adjacent seats of screw systems implanted in other vertebral bodies. A closure mechanism that is configured to lock the polyaxial motion of the rods with respect to the seat and to lock the polyaxial motion of the bone screw with respect to the seat simultaneously or independently is provided. The seat is connectable to a cannula for delivering the first and second rods into the first seat in a percutaneous, minimally invasive procedure.
US08535348B1 Surgical needle holder
The surgical needle holder includes two elongated arms having scissor finger loops on one end and a pair of needle gripping jaws on the opposite end. The elongated arms are pivotally attached to each other. Δ first jaw is pivotally mounted via an actuator rod interconnecting the first jaw to one of the arms, opening and closing with respect to the second jaw as the elongated arms pivot with respect to each other. The jaws are designed to grip a surgical needle when in the closed position. Ratchet lock members attached to the elongated arms lock the jaws in the closed position in a manner similar to the locking of a hemostat. Mechanical configuration of the needle holder allows motion of the needles to be along any plane parallel to the longitudinal axle of the device while the surgeon's hand is in a neutral position.
US08535347B2 Articulating mechanisms with bifurcating control
The invention provides an articulating mechanism useful, for example, for remote manipulation of various surgical instruments and diagnostic tools within, or to, regions of the body. Movement of segments at the proximal end of the mechanism results in a corresponding, relative movement of segments at the distal end of the mechanism. The proximal and distal segments are connected by a set of cables in such a fashion that each proximal segment forms a discrete pair with a distal segment. This configuration allows each segment pair to move independently of one another and also permits the articulating mechanism to undergo complex movements and adopt complex configurations. The articulating mechanisms may also be combined in such a way to remotely mimic finger movements for manipulation of an object or body tissue.
US08535346B2 Pressure cuff holding device
A constructed device for use maintaining an inflatable tourniquet cuff in place on a limb of a person, kits, and methods of using the device are provided. The construction of the cuff holding device prevents a blood pressure cuff or other tourniquet cuff from slipping out of position during use.
US08535345B2 Vasoocclusive coil with biplex windings to improve mechanical properties
The vasoocclusive device for use in interventional therapy and vascular surgery adapted to be inserted into a portion of a vasculature, includes a vasoocclusive coil disposed about an inner reinforcement coil wherein said vasoocclusive coil is helically wound and the inner reinforcement coil forms a reverse helical winding opposite the vasoocclusive coil winding, thereby forming a biplex wound coil. The vasoocclusive device biplex winding provides improved mechanical properties to the device. An inner reinforcement stretch resistant member attached within the biplex windings limits coil stretchability.
US08535344B2 Methods, systems, and devices for providing embolic protection and removing embolic material
An embolic protection device includes a guide member having a distal end, a proximal end, and a lumen extending from the distal end to the proximal end. Additionally, the embolic protection device includes a filter assembly having a plurality of struts extending from the distal end of the guide member. The filter assembly further includes a filter media adapted to filter material from a blood stream coupled to at least two of the plurality of struts. The filter media can have an open proximal end and a closed distal end. The device can also include a sleeve at least partially surrounding the plurality of struts and the filter media for restraining the filter device in a collapsed position during an insertion procedure. The embolic protection device can also include additional loops of material surrounding the struts and a tether wire securing the sleeve and loops in the collapsed position.
US08535338B2 System and method for intervertebral disc bulge reduction
A system and method for treating a bulge in an intervertebral disc annulus fibrosus adjacent to a vertebral body of a patient's spine using a repair device including a suture element, a patch element and a bone anchor. A bore is formed through a portion of the vertebral body, including an endplate thereof adjacent to the intervertebral disc. A suture picker is deployed through the bore and the annulus fibrosus, and the suture element is coupled to the suture picker. The suture picker is withdrawn from the bore. The suture element is pulled so as to draw the patch element against the bulge, and continued tension on the suture element urges the patch and the bulged anteriorly so as to re-approximate the natural shape of the annulus fibrosus. The suture element is secured to the vertebral body using the bone anchor.
US08535336B2 Nested cannulae for minimally invasive surgery
The present disclosure provides for systems and methods for Nested Cannula configuration. Nested Cannula systems include a plurality of telescoping, pre-shaped tubes configured and dimensioned to reach target locations within a particular anatomical region. A three dimensional image is read for the particular anatomical region and structure in question. A series of arcs are generated between a point of the anatomical region and a target location, ensuring collision-free motion for each of the tubes at each specific diameter. The target location is determined based upon the medical procedure being performed and the location and orientation in six degrees of freedom of the anatomical structure in question. The series of arcs are used to configure and dimension the plurality of tubes. The Nested Cannula system is adapted to reach relatively small and complex target locations, such as to deliver photodynamic therapy, balloon angioplasty or BronchoAlveolar Lavage.
US08535334B2 Complex wire formed devices
The devices and methods described herein relate to jointless construction of complex structures. Such devices have applicability in through-out the body, including clearing of blockages within body lumens, such as the vasculature, by addressing the frictional resistance on the obstruction prior to attempting to translate and/or mobilize the obstruction within the body lumen.
US08535333B2 Ocular implant applier and methods of use
Described herein is a delivery device and methods for delivering an ocular implant into an eye. The delivery device includes a proximal handle portion; a distal delivery portion coupled to a distal end of the handle portion and configured to releasably hold an ocular implant and includes a sheath positioned axially over a guidewire; and a metering system configured to provide visual guidance regarding depth of advancement of an implant positioned on the guidewire into an anatomic region of the eye. Also disclosed is a device and method for loading an implant onto the delivery device.
US08535330B2 Arthroscopic tibial sizer
An arthroscopic tibial sizer provided with a collapsible loop (for example, a nitinol loop) and a pin indicator located at about the center of the collapsible loop. The collapsible loop is formed of a flexible wire (for example, nitinol wire) and is designed to collapse so that it can be inserted through an arthroscopic portal and into the joint, and then to expand out to its original diameter once inside the joint space, for visual sizing. The collapsible loop may be provided in various diameters (i.e., 14, 17 or 20 mm, for example) to match various implant sizes. The pin indicator indicates the center of the loop and provides identification of the center of the tibial defect.
US08535326B2 Insertion instrument for an intervertebral implant
In an insertion instrument for a three-piece intervertebral implant that includes an upper part that can be placed against a vertebra, a lower part that can be placed against the adjacent vertebra, and a pivot element that can be inserted between these two parts, the instrument having two arms, disposed side by side and supported pivotably relative to one another on one end, which at their free ends each have one retention device for the upper part and lower part, respectively, of the intervertebral implant, it is proposed that a longitudinal guide for the pivot element is disposed in one of the arms.
US08535324B2 Prosthetic acetabular cup inserter and impactor
A prosthetic acetabular cup inserter and impactor has an expandable annular cup engaging element to engage the inner surface of a cup to be inserted in the acetabulum. An expander is provided for expanding the cup engaging element which is connected to one end of a handle via a hollow or partly hollow extension portion. The other end of the handle is provided with an anvil. An elongate operator is located within the extension portion and connected to the cup engaging element. A device is provided for moving the elongate operator to pull the cup engaging element towards the expander.
US08535318B2 Minimally invasive instrument set, devices and related methods
A minimally invasive system includes a bone screw and a tissue retractor having distal and proximal end portions and a partial pathway therebetween. The tissue retractor is removably couplable to the bone screw. An instrument has distal and proximal end portions and a hollow cavity and is removably couplable to the tissue retractor. A drive shaft has a diameter less than a diameter of the hollow cavity and is rotatable with respect to the instrument. A counter-torque handle has gripping and an interlock end portions with an instrument interface releasably positioned within the hollow cavity at the proximal end portion thereof and rotatably fixed thereto in an assembled configuration. The interlock end portion also includes an open-ended slot having a width greater than the drive shaft diameter such that the counter-torque handle is movable to and from the assembled configuration while the drive shaft is within the hollow cavity.
US08535313B1 Bone plate with suture retaining elements
A bone plate has a body with an outer surface and a bone-contacting surface with a channel formed at a periphery of the body, and a suture member having an end slidably received in the channel. The suture member has an end extending outwardly of the channel. The channel is formed along at least one side of the body. The suture member includes a retainer member received in the channel, a shank extending through the channel, and a loop member affixed to the end of the shank opposite the retainer member. The loop member has a shape suitable so as to allow a suture to be affixed thereto. The body has a slot communicating with the channel and opens at the outer surface so as to allow the suture member to be inserted into the channel.
US08535311B2 Electrosurgical instrument comprising closing and firing systems
An electrosurgical surgical instrument can comprise a handle and an end effector, wherein the end effector can comprise first and second jaws which can be opened and closed to capture tissue therebetween. The handle can comprise a closure drive for closing the jaws and a firing drive which can be actuated independently of the closure drive. In various embodiments, a single trigger can be utilized to actuate both the closure drive and the firing drive, wherein a first range of motion of the trigger can actuate the closure drive and a second range of motion of the trigger can actuate the firing drive.
US08535310B2 Sphincterotome
A medical sphincterotome and a method of its use are described. The sphincterotome has structural elements that are capable of directing a wire guide through a selected body passageway. One structural element includes a distal port and deflection member that can deflect the wire guide into the desired passageway. Another structural element includes an offset nose-shaped end that can bend towards a passageway desired to be blocked. The wire guide is prevented from entering the blocked passageway, thereby enabling the wire guide to cannulate the desired passageway. The sphincterotome also includes a cutting wire to access a patient's sphincter and perform various other medical procedures.
US08535308B2 High-sensitivity pressure-sensing probe
A medical probe includes an insertion tube, having a longitudinal axis and having a distal end. A distal tip is disposed at the distal end of the insertion tube and is configured to be brought into contact with a body tissue. A joint couples the distal tip to the distal end of the insertion tube. A joint sensor, contained within the probe, senses a position of the distal tip relative to the distal end of the insertion tube. The joint sensor includes first and second subassemblies, which are disposed within the probe on opposite, respective sides of the joint and each include one or more magnetic transducers.
US08535306B2 Ablation devices and methods of using the same
Devices and methods for ablating a selected tissue volume, such as for ablating tumor, are disclosed. In certain embodiments, the ablation devices include a low-conductivity, tissue-piercing tip, an adjustment mechanism for selectively adjusting the length of an exposed portion of the electrode, for producing ablation volumes of desired geometry. In other embodiment, the methods allow the adjustment of the length of the exposed electrode portion be carried out by moving an insulative sleeve along the electrode.
US08535299B2 Method and apparatus for skin reduction
A method for reducing skin is disclosed, in which a plurality of incisions or removals are made to collectively form a patch of skin to be reduced, instead of making a single large treatment of the patch. Thus, scarring after healing is less noticeable. Preferably, the treated regions of skin are arranged such that a total area of all removed skin segments taken in a direction perpendicular to an axis of said patch changes gradually along said axis. The removed regions of skin are preferably navicular in shape, and the patches are preferably navicular in shape in the event an elongated incision is made. The removal of skin regions can be realized by proper treatment methods such as incisions and laser treatment.
US08535298B1 Device and a method for treating vulnerable plaque and cardiovascular diseases
A device and a method for treating Vulnerable Plaque by pulsed focused energy is described. The present invention describe a device and a method for a) breaking through plaque blocking arteries (totally occluded arteries) so that wires and stents can introduced to open the blocked or totally occluded arteries, and b) applying a controlled amount of energy to VP (possibly with cooling or energy removal applied to the surface layers) so that at least some of the constituents of the VP are stabilized or denatured so they can no longer cause blood clotting or are stabilized to prevent emergence into the blood stream and thus prevent clotting. Additionally an imaging method (for example, OCT, side looking OCT, IVUS, Ultrasound, OCT, thermography, IR imaging, Florence imaging, luminescent imaging, MRI, Videography, or other imaging technologies, allow viewing of the progress of the damage caused to the VP blood clot—causing components or the progress in the stabilization of the VP. Imaging of the said treatment effect on the VP in time and space can thus be made simultaneously with the present invention proposed treatment and provide real time feedback on the progress and effect of the treatment described by the present invention.
US08535293B2 Atraumatic ureteral access sheath
Ureteral access sheaths can have a nonuniform axial-stiffness. A nonuniform axial-stiffness ureteral access sheath can have an inner liner defining a longitudinally extending and generally uniform bore. A non-uniform axial-stiffness outer jacket can define a longitudinally tapered outer surface, and a reinforcement layer can be encapsulated between the inner liner and the non-uniform axial-stiffness outer jacket. The reinforcement layer can have a non-uniform axial-stiffness. For example, a proximal portion of the reinforcement layer can be thicker than a distal portion of the reinforcement layer. A coil of wire can be included in the reinforcement layer, and a diameter of the wire in a proximal portion of the reinforcement layer can be larger than a diameter of the wire in a distal portion of the reinforcement layer. In some instances, the diameter of the wire tapers from the proximal portion to the distal portion.
US08535289B1 Vial attachment pliers
Vial attachment pliers that include a handle; a static arm that includes a recessed vial adapter slot and extends from the handle such that the longitudinal axis of the static arm is substantially perpendicular to the longitudinal axis of the handle; a guide rod that extends from the static arm such that the longitudinal axis of the guide rod is substantially perpendicular to the longitudinal axis of the static arm; a dynamic arm having a vial slot that is slidably attached to the guide rod; a lever pivotably attached to the handle; and a connector bar connecting the lever to the dynamic arm, such that as the lever pivots relative to the handle, the dynamic arm is urged to slide along the guide rod.
US08535286B2 Vibrating tampon apparatus with remote control
A vibrating tampon apparatus to provide relief from feminine menstrual cramps comprises a vibration element, a housing unit, and a tampon member. The vibration element provides a source of vibrations and is contained within the housing unit. The tampon member is fabricated of an absorbent material and covers at least a portion of the housing unit, while being held in place by retaining elements on the exterior of the housing unit. Electric power is supplied to the vibration element by a remote electric power source. The electrical connection between the electric power source and the vibration element is controlled remotely by a control unit that allows the apparatus to operate either momentarily, in a testing situation, or continually for the lifetime of the electric power source, which is for normal usage and cannot be interrupted by the user.
US08535284B2 Drainage pump unit
The drainage pump unit according to the invention for aspirating body fluids by means of a suction pump comprises a drainage pump device with a pump housing (4) for receiving the suction pump, and a fluid collection container (5) that can be secured releasably on the pump housing (4). The drainage pump unit also comprises a pump-side attachment part (2) which has a connection element for connection to a patient-side drainage tube (10). The attachment part (2) is held releasably on the pump housing (4), and it has a connector piece (20) onto which an attachment opening (54) of the fluid collection container (5) can be fitted. Alternatively, the attachment part (2) can have an attachment opening into which a connector piece of the fluid collection container (5) can be inserted. The connection element and the connector piece (20) or attachment opening are connected to each other via a drainage channel (24) extending through the attachment part (2). This drainage pump unit allows the fluid collection container to be replaced without removing the drainage tube and, therefore, without disturbing the patient.
US08535282B2 Wound healing sensor techniques
The present disclosure is directed at methods and apparatus to evaluate and monitor healing progress of wound and/or to generate data to modify or identify a treatment protocol. Fluid exudate removed from the wound by a negative pressure therapy device may now be analyzed to identify the progress of wound healing, such as whether healing is progressing in a positive manner or experiencing one or more impediments. The fluid exudates may be specifically analyzed for one or more analytes indicative of one or more of the biochemical reactions that may occur during wound recovery. In addition, one may separately utilize optical sensors integrated into a dressing enclosure, optionally in those dressings employed in a negative pressure therapy device. Such optical sensors may then illuminate the wound and collect information regarding the wound via a light scattering type response.
US08535278B2 Extendable plunger rod for medical syringe
An extendible plunger rod for use with a syringe is provided. Example plunger rods may include an outer plunger rod with a proximal end and a distal end, the outer plunger rod having an inner cavity; an inner plunger rod, housed at least partially within the inner cavity of the outer plunger rod; a compression spring disposed within the inner cavity of the outer plunger rod and between the proximal end of the outer plunger rod, and the inner plunger rod, the compression spring configured to exert force tending to push the inner plunger rod in a direction distal to the outer plunger rod; and a locking mechanism, the locking mechanism configured to prevent movement of the inner plunger rod relative to the outer plunger rod while both the inner and outer plunger rods are depressed into a syringe body, until the outer plunger rod has been depressed at least a first predetermined distance into the syringe body.
US08535274B2 System and method for modification of a device and a device suitable for modification
The injection device comprises a housing designed or suitable for manual gripping, a container for a preparation attached/enclosed in the housing, an outlet for the preparation exposed with respect to the housing and a mechanism arranged for moving the preparation at least from the container through the outlet. The system comprises a set of at least two elements having different properties in at least one respect. The elements are designed for mechanical attachment to one and the same area part of the housing, one at the time. The method includes the steps of providing at least two elements having different properties in at least one respect, the elements being designed for mechanical attachment to one and the same area part of the housing, one at the time, selecting one element from the set, and attaching mechanically the selected element to said area part of the housing.
US08535273B2 Device for removing a huber needle from a patient
A one-piece connector for removing a housing and needle of a Huber needle assembly from a patient. The connector has a frame that can be positioned about a surface on the housing of the needle assembly and a pair of wings that pivot toward one another to provide a gripping surface.
US08535271B2 IV-catheter insertion device
The present disclosure is directed to a catheter insertion device, which has a catheter hub at the proximal end of a catheter, a tubular needle hub, at which a hollow needle is fixed and extends through the catheter hub and the catheter in a ready position such that the needle tip projects over the distal end of the catheter, a protective barrel which is received in the tubular needle hub in the ready position and is releasably connected to the catheter hub, and a pressure spring arranged between the needle hub and the protective barrel and which displaces the needle hub and the protective barrel apart from each other in an axial direction, wherein a manually operable holding member is provided between the needle hub and the protective barrel, and holds the needle hub in the ready position at the protective barrel against the bias of the pressure spring, so that after the holding member is released, the pressure spring moves the needle hub into a protective position in relation to the protective barrel, in which position the needle is positioned in the protective barrel.
US08535269B2 Insertion head with a needle protection in its handle
An insertion head for medical or pharmaceutical applications includes a base having a lower side positionable on organic tissue; an insertion means movably mounted by the base and insertable into the tissue; where the insertion means is movable relative to the base from a protective position in which a free end of the insertion means is short of the lower side of the base, into an insertion position in which the free end protrudes beyond the lower side; and a receptacle that is open towards the lower side of the base and that can be detached from the base, and which accommodates at least the free end of the insertion means in its protective position.
US08535266B2 Retractable safety syringe
A retractable safety syringe may have a ferrule and needle which are selectively removeable from a distal end of a syringe body. In particular, the ferrule may have an annular flange. A wedge element may be frictionally engaged to the ferrule and a distal end of the syringe body. To retract the needle into the syringe body, a punch of a piston displaces the wedge element off of an annular flange of the ferrule. At about the same time, longitudinally offset tabs engage an annular flange and retract the needle into the syringe body via a retraction force created by a variable vacuum compartment or tension member.Alternatively, the ferrule and needle may be temporarily fixed to the distal end of the syringe body via a detent and/or o-ring which engages a lower undercut groove and an upper undercut groove of the ferrule. An annular ring of the piston may have longitudinal offset tabs which engage an annular ring of the ferrule. Upon engagement, the retraction force of the variable vacuum compartment is sufficient to overcome any retaining forces created by the detent and/or the o-ring. Thereby, the needle and ferrule may be retracted into the syringe body.The longitudinal offset tabs may cant the needle when the needle is retracted into the syringe body.
US08535265B2 Tracheal catheter with suction lumen port in close proximity to the cuff
Endotracheal and tracheostomy tubes have an inflatable cuff for sealing the trachea so that a patient may be ventilated through a respiratory lumen of the tube. As a result of sealing the trachea outside of the tube, liquids accumulate above the cuff. If these liquids are allowed to move into the lungs, they may cause ventilator acquired pneumonia (VAP). The liquids may be removed by suction applied to a suction lumen terminating in a port above the cuff, but suctioning can cause damage to the trachea if the tube is sucked up against the tracheal wall. A tracheal catheter having a unique method of attaching the balloon cuff is provided. The cuff is to attached so that an upper part (collar) of the cuff is used to cover the distal end of a suction lumen port. This allows the port to be located closer to the cuff and so provides more thorough liquid removal and reduces the possibility that the tube may suck itself onto the tracheal wall.
US08535263B2 Single-use injector capable of pumping and having a flexurally elastic housing
A single-use injector comprising a housing (200) accommodating a mechanical spring energy reservoir (50), a cylinder/piston unit (100), a piston-actuating ram (60) and a trigger unit (80), the spring-locked piston-actuating ram (60) being supported on the housing via support rods, draw hooks or elastic flexural beams. The housing of the injector consists of a thin-walled sheet metal part. Said sheet metal part supports the pretensioned spring energy reservoir and the cylinder/piston unit. The piston (111) of the cylinder/piston unit can be manually displaced by means of a pump rod (140). The single-use injector is compact and has few components, is easy to handle and allows secure storage and functioning. The cylinder/piston unit can be filled when mounted.
US08535259B2 Methods for biliary diversion
Methods are provided for biliary diversion. In one embodiment, a tubular member can be implanted within a patient by positioning a proximal end of the tubular member in the patient's gall bladder, positioning a distal end of the tubular member in the patient's intestine, and positioning a length of the tubular member extending between the proximal and ends thereof within the patient's stomach. Bile can therefore be allowed to pass from the gall bladder into the tubular member's proximal end, flow through the tubular member, and exit through the tubular member's distal end to enter the patient's gastrointestinal tract at the intestine.
US08535255B2 Therapeutic boots stabilization wedge
A device for stabilizing a limb, typically when the limb is in a therapeutic boot. A wedge-shaped stabilization block includes an outwardly-extending tether. A fastener in the form of spaced fastener elements is located on the tether for securing the stabilization block in place.
US08535250B2 Method and apparatus to detect the fragmentation of kidney stones by measuring acoustic scatter
During shock wave therapy, a determination is made that a kidney stone has begun to fracture, and then a progress of its fragmentation is assessed. This determination can reduce the number of shock waves used to disintegrate kidney stones, and thereby reduce dose-dependent tissue damage. The identification of fracture is possible through the detection and analysis of resonant acoustic scattering, which is the radiation caused by reverberations within a stone particle that is struck by a shock wave. The scattering frequency can provide both an indication that the kidney stone has fragmented, and an indication of the relative sizes of the fragments. Related concepts employ displacement measurements of kidney stones/fragments to provide both an indication that the kidney stone has fragmented, and an indication of the relative sizes of the fragments. Such techniques can be combined with vibro-acoustography based gating that better targets the stone.
US08535245B2 Catheter deployment device
An apparatus for deploying a needle within a lumen is provided. The apparatus includes a housing having a threaded bushing radially disposed therein. The bushing rigidly couples with a nose cone having a guide tip disposed at an end opposite the bushing for penetrating an arterial wall of a lumen. During operation, a user incrementally advances the bushing within the housing, thereby incrementally advancing the guide tip into the lumen. The nose cone also includes a flex guide having a slot configuration which couples with the guide tip which deploys into the lumen along with the guide tip.
US08535240B2 Tissue excision device with a retracting stylet blade
A biopsy device includes a coring cannula, a retract stylet, and a localization needle. The coring cannula has a longitudinal axis and a shaft centered on the axis. The stylet has a tip containing at least one blade and a central passage. The localization needle has a channel and is slidably disposed within the central passage. A drive mechanism rotates the cannula and moves the cannula in a direction parallel to the longitudinal axis of the cannula. A guide element has a first end and a second end and is slidably disposed within the channel of the localization needle. The guide element is movable from a first position to a second position within the localization needle.
US08535238B2 Diagnostic methods for osteoporosis
Methods of diagnosing bone disease such as osteoporosis are provided. The methods comprise detecting changes in the physical or chemical structure of a keratinized tissue as correlates of disease. The methods include detecting changes in the hardness, modulus, or level of sulfur bonding, particularly the level of disulfide bonding, in a keratinized tissue sample such as nail, hair, or skin. Changes in these variables serve as diagnostic markers of bone diseases that are associated with changes in bone elasticity and bone density.
US08535237B2 Continuous intra-abdominal pressure monitoring system
Described herein are devices, systems, kits and methods for continuously measuring intra-abdominal pressure (IAP) from a patient catheterized with a urinary catheter system Devices may include a lumen configured to connect to a pressure transducer, and a compensation chamber in fluid communication with the lumen and a urinary catheter.
US08535231B2 Ultrasonic diagnostic apparatus
An ultrasonic diagnostic apparatus is provided with an ultrasonic probe, an ultrasonic image generating section, a head mounted display (HMD), and an orientation measurement section. The ultrasonic probe has two-dimensionally arranged ultrasonic transducers. The ultrasonic image generating section generates a 2D ultrasonic image representing a cross section of a three-dimensional area inside of a patient's body. The HMD has an orientation sensor for outputting signals corresponding to motion of the HMD and a projector for projecting images and the like within the view of an operator Op. The orientation measurement section measures rotation direction and rotation angle of the operator Op's head (HMD). A plurality of cross sections of the three-dimensional area inside of the patient's body for which the 2D image is generated is preliminary set, and the generated 2D ultrasonic image is switched according to the rotation direction and the rotation angle of the HMD.
US08535229B2 Ultrasonographic device
An ultrasonographic technique capable of forming a transmission beam enabling multi-beam transmission/reception of identical transmission sensitivity. An ultrasonographic device for imaging inside of an examinee includes a transmitter for transmitting an ultrasonic pulse signal from an ultrasonic element array to the examinee, and a receiver for receiving the ultrasonic pulse reflected from the examinee. The transmitter transmits an ultrasonic pulse signal having a plurality of peaks of substantially equal transmission intensity in the azimuth direction and a trace in the depth direction of each peak as a substantially straight line, from a transmission opening of the ultrasonic element array to the examinee.
US08535228B2 Method and system for noninvasive face lifts and deep tissue tightening
A method and system for noninvasive face lifts and deep tissue tightening are disclosed. An exemplary method and treatment system are configured for the imaging, monitoring, and thermal injury to treat the SMAS region. In accordance with an exemplary embodiment, the exemplary method and system are configured for treating the SMAS region by first, imaging of the region of interest for localization of the treatment area and surrounding structures, second, delivery of ultrasound energy at a depth, distribution, timing, and energy level to achieve the desired therapeutic effect, and third to monitor the treatment area before, during, and after therapy to plan and assess the results and/or provide feedback.
US08535218B2 Capsule endoscope
A capsule endoscope is disclosed that includes first and second objective optical systems for forming images of objects viewed in the capsule insertion direction and in the opposite direction on separate areas of one plane where an image pickup surface of an image pickup device is located. The capsule endoscope also includes illuminators for illuminating the objects, and a deflector or deflectors, such as reflecting prisms, for folding light from the objective optical systems to the image pickup surface so that the image pickup surface is parallel to the capsule insertion direction. The objective optical systems are retrofocus optical systems. The illuminators may have emission surfaces centered on the centers of spheres defined by dome-shaped transparent covers aligned along a central axis of the capsule endoscope. The objective optical systems, the deflector or deflectors, and the image pickup device are arranged completely off the central axis of the capsule endoscope.
US08535217B2 Methods and systems for treatment of prolapse
Described are implants, tools, and related methods, for use in pelvic surgery to treat conditions such as prolapse, including embodiments of methods that involve a tissue path above the arcus tendineus.
US08535215B2 Implantable heart monitoring device and method
In an implantable heart monitoring device and method, particularly for monitoring diastolic dysfunction, a control circuit (a) detects the heart rate, (b) derives information correlated to the stroke volume of the heart at the detected heart rate, and (c) stores the detected heart rate and the derived information correlated to the stroke volume in a memory. The control circuit automatically implements (a), (b) and (c) at a number of different occasions for a number of different, naturally varying heart rates, so that the memory contains information indicating the stroke volume as a function of the heart rate.
US08535212B2 Centrifugal blood pumps with reverse flow washout
Blood pumps used as heart assist devices are commonly powered by an external battery and control system. If the external power is interrupted, such as by damaging an external cable, patients will have backflow across the pump. If the flow is too high, they may decompensate and die. If the backflow is relatively low, patients can survive until power is restored, but their blood pump must be sufficiently washed to prevent thrombus. Centrifugal blood pumps have been designed for good pumping performance, low blood damage, and avoidance of thrombus when they are running. The present invention recognizes the need to also provide enough washing to prevent thrombus when the pump power is turned off. The invention provides centrifugal pumps with triple or quadruple volute designs, or with axial flow impellers on the same shaft as the centrifugal pump impeller to help drive the rotor in reverse and enhance washing even with relatively low backflow. Also, in the preferred embodiment the centrifugal rotor is supported by low friction mechanical blood immersed bearings, to avoid contact of the rotor with the housing that creates small poorly washed crevices where thrombus can form.
US08535210B2 System for blood separation with shielded extraction port and optical control
A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.
US08535209B2 Method and system for making a stepped end
A method and apparatus for making a stepped end on a tube of flexible material includes a tube slitting station having a slitting tool with double edge slitting blades penetrating through the tube to provide respective slits beside a first panel and beside a second panel, respectively; a first trimming station trimming a first panel of the tube to a first shortened length, a second trimming station trimming the side gussets to a second length, wherein the second length is longer than the first shortened length of the first panel; and an adhesive applying station applying adhesive on the tube above and below a fold line across the tube, wherein the tube is adapted to be folded along the fold line, and the adhesive material is adapted to form an adhesive to adhesive seal above and below the fold line while the tube is folded to provide a closed stepped end for a bag.
US08535206B2 Mobile elliptically driven device and steering mechanism
A steering mechanism is provided that steers by imparting a variable amount of toe or camber to a wheel, and is capable of imparting both toe and camber using a single mechanism. Some versions of the steering mechanism can provide extremely high stability during turns controlled by the simple leaning of the operator. Vehicles using the mechanism are provided, including lean-steered vehicles, and including a three-wheeled mobile elliptically driven device.
US08535203B2 System and method for idle engine stop
An automatic transmission is disclosed providing eight forward ratios and one reverse ratio wherein the first forward ratio is selected by engaging exactly one friction brake using an electro-mechanical actuator. An operating method is disclosed for a vehicle having a transmission with this characteristic. The disclosed operating method permits the engine to be shut off to save fuel while the vehicle is stationary and then to start moving before an engine driven pump creates hydraulic pressure to engage the clutches.
US08535199B2 Infinitely variable transmissions, continuously variable transmissions, methods, assemblies, subassemblies, and components therefor
Inventive embodiments are directed to components, subassemblies, systems, and/or methods for continuously and infinitely variable transmissions (IVT). In one embodiment, a variator is adapted to receive a control system that cooperates with a shift nut to actuate a ratio change in an IVT. In another embodiment, a neutral lock-out mechanism is adapted to cooperate with the variator to, among other things, disengage an output shaft from a variator. Various inventive mechanical couplings, such as an output engagement mechanism, are provided to facilitate a change in the ratio of an IVT for maintaining a powered zero operating condition. In one embodiment, the output engagement mechanism selectively couples an output member of the variator to a ratio adjuster of the variator. Embodiments of a ratio adjuster cooperate with other components of the IVT to support operation and/or functionality of the IVT. Among other things, user control interfaces for an IVT are disclosed.
US08535198B2 Zero backlash planetary gear train
A zero backlash planetary gear train, comprising: a shell, a planetary gear set, and at least a sun gear set. Planetary gear set is disposed in said shell, and includes a planetary arm rack having output axis, such that planetary arm rack in said shell is provided with a plurality of double-layer planetary gears. The planetary gear set includes a first planetary gear and a second planetary gear. A buffer mechanism is provided between first planetary gear and second planetary gear. Said first planetary gear is engaged with at least an internal gear on an inner rim of shell, and second planetary gear is engaged with at least a sun gear set. Sun gear set is provided with a sun gear connected to a driving motor. Said zero backlash planetary gear train is capable of eliminating backlash between gears.
US08535195B2 Transmission device
A transmission device capable of transmitting power applied to an input shaft to an output shaft while changing a speed ratio to a plurality of stages, including a single-pinion type first planetary gear mechanism; a single-pinion type second planetary gear mechanism; a third planetary gear mechanism; a case that accommodates the first, second, and third planetary gear mechanisms; first and second clutches; and first and second brakes. A first carrier of the first planetary gear mechanism and a second ring gear of the second planetary gear mechanism are coupled together through a coupling member that extends circumferentially inward from the second ring gear, and the second ring gear is coupled to a second brake hub that configures the second brake through the first carrier.
US08535187B2 Motorcycle camshaft drive tensioner
A cam drive tensioner for use with an engine includes a main body mounted to a component of the engine; a shoe movably mounted to the main body, for movement in a first direction; and two or more hydraulic chambers defined between the main body and the shoe, with the two or more hydraulic chambers being laterally spaced apart from each other in a second direction generally perpendicular to the first direction.
US08535182B2 System and method for providing a performance factor for a pitcher
The present invention provides a visual representation of and unique, universal definition for a strike zone, said strike zone having a plurality of sub-zones. The strike zone representation allows for a signaling methodology to be developed in which a coach may discretely communicate signals during a game to his pitcher (ex.—baseball or softball pitcher) which request both a specific type and location for a particular pitch, based upon the game situation. Further, implementation of said signaling methodology based upon said strike zone representation allows for a performance factor to be determined for the pitcher. The performance factor may be determined based on results generated through use of the signaling methodology and may provide a universally-recognized gauge or measure of a pitcher's command of his pitches.
US08535177B1 Golf club head
A cavity back iron type club head includes a striking plate having a substantially planar striking surface and a rear surface defining a thickness therebetween. The rear surface defines a striking plate rear cavity region. A perimeter support is coupled to a peripheral portion of the striking plate. The surface area of the striking surface is related to the club head loft angle by the equation SSA≧14.4(L)+2875, where SSA is the surface area of the striking surface in units of square-millimeters and L is the club head loft angle in units of degrees.
US08535175B2 Golf club shaft and golf club
A shaft 6 includes a textile layer. The textile layer has a biaxial textile 20 composed of warps and wefts. The warp is oriented substantially parallel to an axial direction of the shaft. The weft is oriented substantially perpendicularly to the axial direction of the shaft. When a tensile elastic modulus of the warp is defined as ET (tf/mm2) and a tensile elastic modulus of the weft is defined as EY (tf/mm2), the tensile elastic modulus ET is smaller than the tensile elastic modulus EY. Preferably, the warp is a PAN carbon fiber and the weft is a pitch carbon fiber. Preferably, when a tensile strength of the warp is defined as ST (kgf/mm2) and a tensile strength of the weft is defined as SY (kgf/mm2), the tensile strength ST is greater than the tensile strength SY.
US08535170B2 Device and method for displaying golf shot data
Golf club telemetry equipment sends signals to a receiver in a golf round data system. The signals uniquely identify the particular club a player has selected for a stroke and the fact that a stroke has been taken. The club identification can occur either before or during a stroke. Automatic detection of clubs and strokes simplifies round data collection for the player. Club identification before a stroke permits a forecast of the result of the stroke to be presented to then player prior to the stroke. The signals can be either acoustic or electromagnetic.
US08535166B1 Stylized support and accessory holder for a video game console
A stylized support and accessory holder for an electronic game console, having an overall shape of an insect or other animal. The support base raises an electronic game console above the floor to minimize intake of dust and other debris often circulating near the floor of a room. In addition, the base may include one or more fans to improve air circulation within the game console. Recharge stations are provided for controllers. An internal circuit breaker is used to protect multiple accessory outlets on the body of the support base. The support base is designed to be decorative and whimsical, but practical. The base supplies electrical power, cooling air, and recharging power for controllers or accessories, as well as electrical power for accessories. All supplied power is protected by a built-in circuit breaker.
US08535165B2 Setting up on-line game sessions out of a game context
A service that provides for setting up game sessions for a plurality of game players. A number of game players that each have a computing device capable of playing a computer game are linked together by the service. The service allows a player to set up a common game session so that a subset of the players can simultaneously start playing the game at the same level. Additionally, the service allows game competitions to be structured and played among a subset of the game players.
US08535164B2 Network gaming system
A gaming system is disclosed that provides an opportunity to win a prize in response to game play, each game being played in exchange for monetary input. The gaming system includes a game server and a plurality of game units connected via a network. The game units each include a web browser. The game system enables a player to receive a prize at a casino game unit in response to winning game play, wherein the prize comprises a physical prize, coins, cash, or a ticket voucher for a physical prize, coins, or cash. The gaming system enables game units to request games from the game server over the network. The games may be downloaded over the network from the game server to the requesting game unit to be executed at the game unit and to be displayed in one or more web browsers.
US08535160B2 Secondary game
In various embodiments, secondary players may participate in games originally played by primary players. Secondary players may make bets and receive winnings based on such games. Secondary players may participate in games from the past. Secondary players may participate in games from locations that are remote to the locations in which the games were first played.
US08535159B2 Information processing method and server system
A league is formed by a given number of teams formed by a plurality of players and having an identical team level, and the teams compete for league ranking based on team points obtained in a given period. A team level of each team is changed based on the league ranking. The player plays a game using a game device to obtain the team points.
US08535157B2 Wireless gaming network
A gaming system that provides game play in exchange for monetary input per game played is disclosed. The gaming system includes a game server and a plurality of gaming units connected to the game server over a network. The game server stores one or more games in electronic form. The gaming units are at least partially connected to the game server using a wireless network. The gaming system enables one or more games to be downloaded over the network from the game server to one or more gaming units.
US08535156B2 Gaming system and method for providing a bonus game with a choice by another player(s)
A gaming system having a plurality of game devices, a game controller and a shared experience controller and a method for operation thereof is disclosed. Each game device allows a player to make a wager on a game and awards the respective player an award as a function as a result of a winning condition for the game played by the respective player. The game controller is coupled to the game devices for playing the game, randomly establishing the actual outcome of the game, and determining if any of the players have a winning condition. The shared experience controller is coupled to the game devices for recognizing a bonus condition for one of the players, responsively providing a choice of items to one or more other players, and providing a bonus award to the one player and/or any of the other players in response to selection of on of the items.
US08535154B2 Information storage medium and image generation device
An image generation device includes a capture direction specifying section, a capture target specifying section, a marker placement control section that disposes a marker at the capture point, and an image generation section, the capture target specifying section determining whether or not the capture target is present in the capture direction, and specifying the capture target when the capture target is present, and the marker placement control section performing a depth value correction process that corrects the depth value of the capture point when a transition has occurred from a state in which the capture target is present to a state in which the capture target is not present.
US08535152B2 Integrated game function in a personal mobility vehicle, such as a wheelchair
A personal mobility vehicle, such as a wheelchair system, includes a user interface that includes a user input and a display for displaying information to the user and a control unit that includes a data processor and a memory. The data processor is responsive to the user entering information into the personal mobility vehicle, where the information indicates a user selection of a game function integrated into the personal mobility vehicle, to enable the user play a game via the user interface. The operation of playing the game includes a preliminary step of switching at least a portion of the user interface from a normal mode of controlling some function, such as mobility, of the personal mobility vehicle to a game playing function.
US08535151B2 Multimedia-based video game distribution
A method includes receiving a multimedia data stream at a device and sending data of a first channel of the multimedia data stream to a display device to generate a presentation of available video games. The method includes receiving user input selecting a first video game of the available video games and sending an identification of the device and a channel indicator corresponding to an encrypted second channel having video game data associated with the first video game to a content provider. The method includes receiving a decryption key for the encrypted second channel in response to verification of the identification of the device. The method also includes decrypting the encrypted second channel, beginning storage of the video game data in response to detecting a starting byte of the video game data, and ending storage of the video game data when the starting byte is redetected.
US08535143B2 Gaming machine having enhanced bonus game play schemes
A gaming machine has a wager-input device for receiving a first wager from a player to play a wagering game having a basic game and a bonus game. A display displays a plurality of symbols located thereon during the basic game. The symbols indicate a randomly-selected outcome selected from a plurality of outcomes in response to the wager. The plurality of outcomes includes a bonus-triggering outcome. A set of available game-enhancement parameters is displayed and the player is provided an option of submitting a second wager to purchase at least one of the set of available game-enhancement parameters. The set of available game-enhancement parameters provides an enhancement selected from the group consisting of: additional bonus-triggering outcomes providing a higher probability of triggering the bonus game, and enhanced awards during the bonus game.
US08535140B2 System and method for providing a baccarat game based on financial market indicators
A system comprises a client operable to communicate a bet regarding a baccarat game. The system further comprises a controller communicably coupled to the client and operable to determine a result of the baccarat game, the result based at least in part upon one or more digits of at least one financial market indicator at a configurable point in time. The controller is further operable to determine an outcome of the bet based at least in part on the determined result.
US08535138B2 Computer graphics processing and system for displaying wagering information for dynamic financial market indicators
Systems and methods for providing a wager in a financial market environment are provided. An interface comprising odds and betting icons may enable users to bet that, at a designated future time, a measurable financial value such as a market index will be above or below one or more currently displayed values. The currently displayed values may comprise a current value of the financial value and/or values above or below the current value. The displayed value(s) may change as the financial value changes. The financial value may be tracked for the duration of the bet, and payouts may be made based on winning bets.
US08535134B2 Method and system for electronic interaction in a multi-player gaming system
A system for electronic interaction in a multi-player lottery system preferably displays information to players regarding various variable duration game rooms. The game rooms may be for durations such as 5 minutes, 10 minutes, half an hour, and hour, a week or a month. The player may optionally be provided further information about the game rooms, such as the current prize amounts or the remaining duration of the game room. A clock or time indicates the end of game play in the room. A point tally system including a processor for ranking the players score relative to one another, and a memory for storing the information, the point tally system providing the ranking information to the displays, the point tally system selecting at least the player with the highest score at the expiration of game play as determined by the timer for the variable duration game room. Preferably, the system includes a payment system for providing the lottery winnings to the winner.
US08535129B2 Straw walker for a combine harvester
A straw walker for a combine harvester includes a straw walker grate provided with through-openings for grain to be separated and with driving profiles arranged along the straw walker grate at a mutual distance from one another. The driving profiles extend transversely to the conveying direction and include a first respective profile limb upwardly protruding from the straw walker grate. In order to provide advantageous conveying conditions, the driving profiles also include a second respective profile limb descends in the conveying direction towards the straw walkers grate. The second respective profile limb is provided between the first respective profile limb and the straw walker grate on the breast side of the driving profiles. The breast side of the driving profiles is at the rear of the driving profiles in the conveying direction.
US08535124B1 Poultry tender tendon clipper
An apparatus and method for preparing a poultry carcass for the removal of breast tenderloins therefrom. The apparatus includes a support frame positioned adjacent a conventional cone line that conveys poultry carcasses along a product path in a downstream direction. A cutting blade is mounted to the support frame and extends into the product path. The cutting blade has a piercing tip and a sharp edge that pierce and sever the connective tissue and tendon that connect a lower portion of a wishbone to a carcass that is conveyed along the blade. A separating fin extends from a top of the cutting blade for engaging the severed wishbone and folding it upwardly, away from the tenders of the carcass. A rotary tendon slicer is mounted to the support frame downstream from the cutting blade and extends into the product path for severing tendons that attach the tenders to the carcass.
US08535123B2 Deboner
Deboning modules 50 move along a processing path for deboning poultry legs or wings having bones connected by an intermediate joint. The modules each include an ankle knuckle holder 60 and a hip knuckle holder 90 for supporting the leg and the hip bone in alignment with each other. Stripping claw 154 and hip knuckle holder 90 move toward each other for stripping meat from the leg bone and hip bone toward the intermediate leg joint. A cylinder blade 71 moves about the ankle knuckle holder toward the hip knuckle holder for cutting the accumulated meat at the hip knuckle holder.
US08535121B2 Retaining ring and articles for carrier head
A carrier head for chemical mechanical polishing that has a base, a mounting assembly connected to the base having a surface for contacting a substrate, and a retaining ring secured to the base. The retaining ring can include perfluoroalkoxy, polyetherketoneketone, polybenzimidazole, a semi-crystalline thermoplastic polyester, or a long molecular chain molecule produced from poly-paraphenylene terephthalamide.
US08535117B2 Method and apparatus for polishing a substrate having a grinded back surface
A method capable of quickly polishing an angular portion formed by a grinded back surface and a circumferential surface of a substrate without causing damages on the thin substrate is provided. The method includes rotating the substrate about its center, and pressing a polishing tape against the angular portion formed by the back surface and the circumferential surface of the substrate to polish the angular portion.
US08535113B2 Methods to control a process
A system comprising a system comprising a valve; a controller adapted to actuate the valve; a pressurized source connected to the valve; a hose and nozzle assembly connected to the pressurized source through the valve; and a switch connected to the nozzle assembly; wherein a flow from the pressurized source to the nozzle may be interrupted by the valve and by the nozzle.
US08535111B2 Spinning toy action figure
An apparatus that includes a core body, a rotational spring motor and several flexible limbs. One of the flexible limbs is the, “the drive arm” and connects to the motor inside the body. The drive arm has a connection point at the other end (hand) that allows it to connect to other like toys.