Document Document Title
US08471152B2 Microstructure and microstructure manufacture method
A microstructure comprises a laminate structure having a first conductor, a second conductor, and an intervening insulator located between the first and the second conductors. The first conductor includes opposite faces in relation to the second conductor, side faces, and edge parts which form the boundaries of the aforementioned opposite faces and side faces. The second conductor includes an extended face extending beyond the edge parts exceeding the first conductor. The insulation film includes an area covering at least part of an edge part and/or at least part of a side face.
US08471146B2 Breaker tray for a panelboard cover
A cover for use with a panelboard enclosure. The cover includes a cover element for mounting onto a panelboard enclosure. The cover element includes an insert for insertion into a cover opening. A plate section is attached to the insert along peripheral edges of the plate section by a thin wall section to form a cover suitable for use with a main lug panelboard configuration. The thin wall section is sized relative to the plate section to enable separation of the plate section from the insert by a user to then form a cover suitable for use with a main breaker panelboard configuration.
US08471145B2 Terminal box and solar cell module
A terminal box has a box body that has a shape of a box having an opening on one surface, has a body-side hinge structure on an end thereof, and accommodates therein an output-cable connecting unit, and a cover that has a cover-side hinge structure forming a hinge structure with the body-side hinge structure, that is pivotally supported by the hinge structure an end thereof so as to pivotally open or close the opening of the box body. The hinge structure has an attitude holding structure that holds an attitude of the cover at a position where the cover is at a predetermined angle with respect to the box body.
US08471135B2 Music transcription
Methods, systems, and devices are described for automatically converting audio input signal data into musical score representation data. Embodiments of the invention identify a change in frequency information from the audio signal that exceeds a first threshold value; identify a change in amplitude information from the audio signal that exceeds a second threshold value; and generate a note onset event, each note onset event representing a time location in the audio signal of at least one of an identified change in the frequency information that exceeds the first threshold value or an identified change in the amplitude information that exceeds the second threshold value. The generation of note onset events and other information from the audio input signal may be used to extract note pitch, note value, tempo, meter, key, instrumentation, and other score representation information.
US08471126B2 Plants and seeds of corn variety CV898659
According to the invention, there is provided seed and plants of the corn variety designated CV898659. The invention thus relates to the plants, seeds and tissue cultures of the variety CV898659, and to methods for producing a corn plant produced by crossing a corn plant of variety CV898659 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV898659 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV898659.
US08471125B2 Plants and seeds of corn variety CV700979
According to the invention, there is provided seed and plants of the corn variety designated CV700979. The invention thus relates to the plants, seeds and tissue cultures of the variety CV700979, and to methods for producing a corn plant produced by crossing a corn plant of variety CV700979 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV700979 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV700979.
US08471123B2 Plants and seeds of corn variety CV286014
According to the invention, there is provided seed and plants of the corn variety designated CV286014. The invention thus relates to the plants, seeds and tissue cultures of the variety CV286014, and to methods for producing a corn plant produced by crossing a corn plant of variety CV286014 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV286014 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV286014.
US08471116B1 Maize variety PHN0N
A novel maize variety designated PHN0N and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PHN0N with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PHN0N through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PHN0N or a trait conversion of PHN0N with another maize variety. Inbred maize varieties derived from maize variety PHN0N, methods for producing other inbred maize varieties derived from maize variety PHN0N and the inbred maize varieties and their parts derived by the use of those methods.
US08471112B2 Bean line FIVC6V1001
The invention provides seed and plants of the bean line designated FIVC6V1001. The invention thus relates to the plants, seeds and tissue cultures of bean line FIVC6V1001, and to methods for producing a bean plant produced by crossing a plant of bean line FIVC6V1001 with itself or with another bean plant, such as a plant of another line. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of a plant of bean line FIVC6V1001, including the pods and gametes of such plants.
US08471110B1 Soybean cultivar 16480296
A soybean cultivar designated 16480296 is disclosed. The invention relates to the seeds of soybean cultivar 16480296, to the plants of soybean cultivar 16480296, to the plant parts of soybean cultivar 16480296, and to methods for producing progeny of soybean cultivar 16480296. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 16480296. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 16480296, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 16480296 with another soybean cultivar.
US08471109B1 Soybean cultivar 10110882
A soybean cultivar designated 10110882 is disclosed. The invention relates to the seeds of soybean cultivar 10110882, to the plants of soybean cultivar 10110882, to the plant parts of soybean cultivar 10110882, and to methods for producing progeny of soybean cultivar 10110882. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 10110882. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 10110882, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 10110882 with another soybean cultivar.
US08471101B2 Transgenic plants expressing cytokinin biosynthetic genes and methods of use therefor
The present invention provides an approach to increase yield and vigor in a plant. The present invention describes expressing a heterologous gene in a plant that control cytokinin expression under the control of a cell cycle regulated promoter.
US08471100B2 Environmental stress-inducible promoter and its application in crops
The subject application provides polynucleotides, compositions thereof and methods for regulating gene expression in a plant using a promoter that initiates transcription in an inducible manner. In a further aspect of the invention, methods for modulating expression of a gene product in a stably transformed plant comprising the steps of (a) transforming a plant cell with a DNA construct comprising the disclosed promoter or fragments thereof that are capable of driving the expression of an operably linked nucleic acid sequence operably linked to at least one nucleotide sequence; (b) growing the plant cell under plant growing conditions and (c) regenerating a stably transformed plant from the plant cell wherein the induced expression of the operably linked nucleotide sequence alters the phenotype of the plant.
US08471094B1 Maize variety hybrid X90B061
A novel maize variety designated X90B061 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X90B061 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X90B061 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X90B061, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X90B061. This invention further relates to methods for producing maize varieties derived from maize variety X90B061.
US08471090B1 Maize variety hybrid X8F941
A novel maize variety designated X8F941 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X8F941 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X8F941 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X8F941, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X8F941. This invention further relates to methods for producing maize varieties derived from maize variety X8F941.
US08471088B2 Solvent quality control in extraction processes
The invention concerns the control of solvent systems in processes and apparatus for the separation of aromatic hydrocarbons from non-aromatic hydrocarbons in liquid-liquid extraction, extractive distillation, and the combination thereof.
US08471080B2 Method for the removal of inorganic compounds of biomass from agricultural, forest and urban sources
Described is a methodology aiming to the removal of harmful ash constituents from the ash of biomass, such as alkali metals, chlorine and sulfur, prior to is thermochemical conversion, in order to minimize/eliminate the ash-related corrosion, deposition and agglomeration problems, as well as the emissions of alkali metals, chlorine and sulfur. This removal is achieved by a combined pre-treatment which includes prepyrolysis of biomass at temperatures varying in the range of 200-300° C. and for a period of 5 min up to 2 h, followed by the leaching of the biomass materials using water with a solid/water mass ratio varying from 33 g/L up to 300 g/L with water temperature varying from 13° up to 55° C. and residence time varying from 5 min up to 24 h.
US08471076B2 Process and plant for producing methanol
In the production of methanol from a synthesis gas containing hydrogen and carbon oxides, the synthesis gas is passed through a first, preferably water-cooled reactor, in which a part of the carbon oxides is catalytically converted to methanol. The obtained mixture containing synthesis gas and methanol vapor is supplied to a second, preferably gas-cooled reactor, in which a further part of the carbon oxides is converted to methanol. Subsequently, methanol is separated from the synthesis gas, and the synthesis gas is recirculated to the first reactor. To achieve a maximum methanol yield even with an aged catalyst, a partial stream of the synthesis gas is guided past the first reactor and introduced directly into the second reactor.
US08471074B2 Process for the manufacture of dichloropropanol
Process for manufacturing dichloropropanol according to which, a) in a liquid reaction medium containing water, which is in contact with a gaseous phase, glycerol is reacted with hydrogen chloride under a partial pressure of hydrogen chloride in the gaseous phase greater than 0.2 bar absolute, and b) at least part of the liquid reaction medium and optionally part of the gaseous phase from step a) is (are) subjected to at least one separation operation and, prior to said separation operation, the part of the liquid reaction medium and the part of the gaseous phase from step a) is (are) subjected to bi) at least one treatment for reducing the weight ratio between the hydrogen chloride and the water in the part of the liquid reaction medium so as to attain a ratio less than or equal to the weight ratio between the hydrogen chloride and the water in the binary azeotropic hydrogen chloride/water composition at total pressure of the separation operation, and/or bii) at least one treatment for reducing the weight ratio between the water and the dichloropropanol in the part of the liquid reaction medium so as to attain a ratio less than or equal to the weight ratio between the water and the dichloropropanol in the ternary water/dichloropropanol/hydrogen chloride azeotrope at total pressure of the separation operation.
US08471065B2 High functionality amine compounds and uses therefor
In another exemplary embodiment, an amine functional curing agent has an Amine Hydrogen Functionality (AHF) of at least 7 and an Amine-Hydrogen Equivalent Weight (AHEW) of at least about 50.
US08471064B2 Copolymers of indenofluorene and thiophene
The invention relates to novel copolymers comprising indenofluorene units and units of thiophene or its derivatives, to organic semiconductor (OSC) materials and organic electroluminescent materials comprising the copolymers, to the use of the copolymers and materials in electronic, electroluminescent or electrooptical devices, and to devices comprising the copolymers or materials.
US08471063B2 Michael systems as transglutaminase inhibitors
Described herein are peptide derivatives and peptidomimetics as inhibitors for transglutaminases, methods for their preparation, pharmaceutical compositions containing said compounds as well as uses of said transglutaminase inhibitors in particular for the treatment of coeliac disease and transglutaminase dependent diseases.
US08471062B2 Method of purifying lactic acid by crystallization
Method for purifying lactic acid by crystallization in one or a plurality of steps, characterized in that crystals are formed from an impure aqueous lactic acid solution having a color of >500 Hazen, at a concentration between 85 and 95% by controlling the lactic acid oligomer content expressed in terms of a relative monomer content greater than 80% and controlling the degree of supersaturation of the solution between 1 and 60% in order to obtain lactic acid crystals having a specific surface area by mass of <0.05 m2/g.
US08471061B2 5-aminolevulinic acid salt, process for producing the same and use thereof
A 5-aminolevulinic acid salt which is useful in fields of microorganisms, fermentation, animals, medicaments, plants and the like; a process for producing the same; a medical composition comprising the same; and a plant activator composition comprising the same.
US08471059B2 Method for preparing a trifluoromethanesulfinic acid salt
The present invention relates to a method for preparing a salt of trifluoromethanesulphinic acid termed “triflinic acid”. More specifically, the invention relates to a method for preparing a highly pure triflinic acid salt. The method of the invention for preparing a highly pure triflinic acid salt, starting from an aqueous mixture comprising the latter combined with a trifluoroacetic acid salt and saline impurities resulting from the method for preparing same, is characterized in that said mixture is subjected to the following operations: —first controlled acidification such that the trifluoroacetic acid salt is essentially released in the acid form thereof, the majority of the triflinic acid remaining in a salified form, —optional separation of the salts originating from the acid having been used for the acidification and recovery of an aqueous phase, —separation of the trifluoroacetic acid from the separated aqueous phase comprising the alkaline salt of triflinic acid, trifluoroacetic acid, triflinic acid and the excess strong acid, therefore resulting in an aqueous phase depleted of trifluoroacetic acid but comprising the alkaline salt of triflinic acid, —recovery of the alkaline salt of triflinic acid from the aqueous phase.
US08471058B2 Carbonylation process using bound silver and/or copper mordenite catalysts
Process for the carbonylation of a carbonylatable reactant selected from at least one of dimethyl ether and methanol, by carbonylating the carbonylatable reactant with carbon monoxide in the presence of a catalyst to produce a carbonylation product selected from at least one of methyl acetate and acetic acid. The catalyst is formed by compositing a mordenite loaded with at least one of silver and copper, with an inorganic oxide binder.
US08471054B2 Resorbable phenolic polymers
The invention provides biocompatible resorbable polymers, comprising monomer units having formula (I), formula (II), formula (III) or formula (IV). The polymers degrade over time when implanted in the body, and are useful as components of implantable medical devices.
US08471052B2 High-yield production of organic nitriles
A process is disclosed for producing organic nitriles such as Acetonitrile or Hydrogen Cyanide, in which yields may exceed 90%, undesirable by-products are not produced, and handling of ammonia gas is avoided. In one aspect, a process includes preparing a feed including ammonium salts and water; introducing the feed into a reactor containing a catalyst; and heating the feed in the presence of the catalyst. The catalyst may advantageously include molybdenum on a silica or silica alumina support. The feed may be ammonium acetate in water with about 50 wt % ammonium acetate and the balance water or ammonium formate in water. In another aspect, a process includes preparing a feed including ammonium hydroxide and acetic acid; introducing the feed into a reactor containing a catalyst; and heating the feed in the presence of the catalyst.
US08471041B2 Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same
A method of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine (ABDNAZ) by reacting DNAZ with bromoacetyl bromide and boron trifluoride etherate to produce a mixture comprising ABDNAZ and a salt of DNAZ. Water and a solvent are added to the mixture to form an organic phase comprising the ABDNAZ and an aqueous phase comprising the salt of DNAZ. The organic phase and the aqueous phase are separated to produce an ABDNAZ/solvent solution comprising the ABDNAZ and the aqueous phase comprising the salt of DNAZ. A nonsolvent is added to the ABDNAZ/solvent solution to produce an ABDNAZ/solvent/nonsolvent mixture. The ABDNAZ is subsequently recovered. A composition comprising ABDNAZ is also disclosed.
US08471039B2 Process for the preparation of indoline derivatives and their intermediates thereof
Processes for the preparation of Silodosin and its intermediates comprising reductive amination of compound of Formula (VIII) with a compound of Formula (VII) or a compound of Formula (XV) in a suitable solvent using a reducing agent.
US08471038B2 Bicyclic heterocyclic compound
The invention provides a compound for the treatment or prophylaxis of pathology involving SNS, specifically diseases such as neuropathic pain, nociceptive pain, dysuria, multiple sclerosis and the like. The compound is represented by formula (1) or a pharmaceutically acceptable salt thereof wherein R1 is a hydrogen atom or the like, L is a single bond, —O— or the like, R2 is a phenyl group or the like, X is a carbon atom or a nitrogen atom, and R3, R4, R5a, R5b, R6 and R7 are each independently a substituted or unsubstituted alkyl group or the like:
US08471032B2 Benzimidazole compound in crystal form and salt thereof
The present invention aims to provide a stable form of (R)-2-{3-[1-(acenaphthen-1-yl)piperidin-4-yl]-2,3-dihydro-2-oxo-benzimidazol-1-yl}-N-methylacetamide, which is free of problems of water adsorption and the like, and shows superior water solubility.The present invention provides a crystal and a salt of (R)-2-{3-[1-(acenaphthen-1-yl)piperidin-4-yl]-2,3-dihydro-2-oxo-benzimidazol-1-yl}-N-methylacetamide in a crystal form.
US08471029B2 Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
US08471023B2 Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
The present invention provides processes for the stereoselective synthesis of 6-alpha-amino morphinans. In particular, the invention provides processes for the reductive amination of 6-keto normorphinans by catalytic transfer hydrogenation.
US08471021B2 Sulfur containing heterocycle-fused naphthalene tetracarboxylic acid diimide derivatives, preparation method and use thereof
Sulfur containing heterocycle-fused naphthalenetetracarboxylic acid diimide derivatives represented by formula (I) are disclosed, in which, R1 and R2 are C1-C30 and C1-C12 linear alkyl or branched alkyl, respectively; R3 is H or halogen atom. The preparation method of the derivatives and the use thereof in manufacture of organic thin film field effect transistor or organic solar batteries are also disclosed.
US08471018B2 Photosensitizer and photovoltaic device
Disclosed is a novel photosensitizer that can absorb light in a wide visible light region and in the case of a very thin film form, can enhance a light absorption efficiency by virtue of a large light absorption coefficient. The photosensitizer is used for metal oxide semiconductor electrodes and comprises a metal complex represented by a general formula ML1L2X2, wherein M is a group 8 transition metal of the periodic table, Xs are each independently a halogen atom, a cyano group, a thiocyanate group, an isothiocyanate group, an isocyanate group, an isocyanide group or a hydroxyl group, or a bidentate ligand in the case where Xs are bonded to one another, L1 and L2 are each a ligand having an aromatic ring, and either L1 or L2 has a functional group having a COOH group or PO(OH)2, and when the photosensitizer is adsorbed on a metal oxide semiconductor electrode via ligands L1 and L2, the difference ΔL between the energy levels of ligands L1 and L2 in their excited states, calculated in accordance with a GAUSSIAN03 quantum chemistry calculation program is 0.25 eV or more.
US08471017B2 Quinoxaline derivative, and light-emitting element, light-emitting device, electronic device using the quinoxaline derivative
It is an object to provide a novel bipolar organic compound. In particular, it is an object to provide a bipolar organic compound excellent in thermal stability. Further, it is another object to provide a bipolar organic compound which is electrochemically stable. A quinoxaline derivative represented by a general formula (1) is provided. Further, since the quinoxaline derivative represented by the general formula (1) is bipolar, the use of the quinoxaline derivative of the present invention allows fabrication of a light-emitting element and a light-emitting device with a low driving voltage and low power consumption. Furthermore, a light-emitting element with high luminous efficiency can be obtained.
US08471011B2 Preparation of acid addition salts of amine bases by solid phase—gas phase reactions
A process for the preparation of an acid addition salt of an organic base comprising exposing the organic base in solid form to a gaseous acid, with the proviso that ziprasidone, its acid addition salts and intermediates thereof are excluded.
US08471010B2 Synthesis of dihydrothieno[3,2-d]pyrimidine diols
The present invention relates to an improved process for the preparation of dihydrothieno[3,2-d]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.
US08471007B2 Method for producing 1,3,5-triazine carbamates and ureas
Process for preparing higher 1,3,5-triazine carbamates and 1,3,5-triazine ureas from lower 1,3,5-triazine carbamates.
US08471001B2 Method for production of limulus-positive glycolipid, the limulus-positive glycolipid, and composition containing the limulus-positive glycolipid
It has been found that a limulus-positive glycolipid is present in xanthan gum derived from Xanthomonas, which has been commercially available and eaten for many years, and this was purified, and it has been found that this limulus-positive glycolipid has an immunopotentiation effect. A method for safely and inexpensively producing the limulus-positive glycolipid containing an immunopotentiator at high concentrations is provided. The method for producing the limulus-positive glycolipid of the present invention comprises extracting the limulus-positive glycolipid from xanthan gum. A limulus-positive glycolipid composition containing the limulus-positive glycolipid can be used for various applications such as pharmaceuticals, pharmaceuticals for animals, quasi drugs, cosmetics, foods, functional foods, feedstuff and bath agents.
US08470998B2 Positive controls for expression modulating experiments
The invention pertains to the use of an apoptosis inducing combination of at least a. a first expression modulating compound silencing the expression of at least a first target gene involved in apoptosis and b. a second expression modulating compound silencing the expression of at least a second target gene involved in apoptosis as a positive control in expression modulating assays. Also provided are suitable methods, kits and compositions.
US08470997B2 Pharmaceutical composition for preventing, stabilising and/or inhibiting blood and lymph vascularization
A pharmaceutical composition including as active agent, an antisens oligonucleotide having the sequence SEQ ID NO: 1 in a concentration from about 0.40 mg/ml to about 2 mg/ml and the use thereof for preventing, stabilizing and/or inhibiting blood and lymph vascularization.
US08470996B2 Methods and compositions for tagging and identifying polynucleotides
The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the oligonucleotide tags of polynucleotides selected in such assays. Words, or subunits, of oligonucleotide tags index submixtures in successively more complex sets of submixtures (referred to herein as “tiers” of submixtures) that a polynucleotide goes through while successive words are added to a growing tag. By identifying each word of an oligonucleotide tag, a series of submixtures is identified including the first submixture that contains only a single polynucleotide, thereby providing the identity of the selected polynucleotide. The analysis of the words of an oligonucleotide tag can be carried out in parallel, e.g. by specific hybridization of the oligonucleotide tag to its tag complement on an addressable array; or such analysis can be carried out serially by successive specific hybridizations of labeled word complements, or the like.
US08470995B2 Enzymes involved in triterpene synthesis
This invention relates to isolated polynucleotides encoding enzymes consisting of a carboxypeptidase-like protein, a methyltransferase and a glucosyltransferase, involved in the biosynthesis of β-amyrin-derived triterpenes in plants and seeds. The invention also relates to the construction of recombinant DNA constructs comprising all or a portion of the isolated polynucleotides of the invention, in sense or antisense orientation, operably linked to at least one regulatory sequence.
US08470993B2 Nucleic acid encoding antibody to human IL-22
The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22 activity, thereby modulating immune responses in general, and those mediated by IL-22 in particular. The disclosed compositions and methods may be used for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, septic shock, infectious disorders, transplant rejection, cancer, and other immune system disorders.
US08470987B2 Protective group for synthesis of RNA and derivative
A protective group represented by the following general formula (I) (the oxygen atom attached with * represents oxygen atom of 2′-hydroxyl group of a ribonucleoside, a ribonucleotide or a derivative thereof; R1 and R2 both represent hydrogen atom, or represent a halogen atom, a C1-6 alkyl group, or a C1-6 halo-substituted alkyl group; R3 and R4 represent hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 halo-substituted alkyl group; and R5 and R6 represent a halogen atom, a C1-6 halo-substituted alkyl group, cyano group, nitro group, or the like), which is stable under the reaction conditions of the nucleic acid synthetic cycles and has little steric hindrance, and can be removed under mild conditions using fluoride ions as a base.
US08470986B2 Method for production of sugar oxazoline derivative
A method for producing an oxazoline derivative from a non-protected sugar in a simple manner and a method for producing a glycoside by utilizing the product of the aforementioned method are disclosed. A sugar oxazoline derivative is synthesized in one step in an aqueous solution from a sugar having a free hemiacetal hydroxy group and an amide group by using a haloformamidinium derivative as a dehydration/condensation agent. A glycoside is produced by using the oxazolidine derivative as a sugar donor and also using a sugar dehydrogenase. The method can be applied to the production of a compound having a long sugar chain, and is therefore useful for a production of a physiologically active oligosaccharide, a carrier for a drug delivery system, a surfactant, a carbohydrate pharmaceutical, a glycopeptide, a glycoprotein, a carbohydrate polymer or the like.
US08470981B2 Additives for the improved dewatering of corn gluten
The invention relates to a method of dewatering corn gluten stream wherein coagulant is add to the corn gluten stream of the corn wet milling process. The method of dewatering corn gluten uses an effective amount of a coagulant of one or more anionic polymers, the anionic polymers comprising one or more anionic monomers. The method further includes a process for separating the water from the gluten using a solids/liquids filtration device.
US08470973B2 Modular DNA-binding domains and methods of use
The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically recognize one or more base pairs in a DNA sequence and, to DNA which is modified so that it can be specifically recognized by a polypeptide and to uses of the polypeptide and DNA in specific DNA targeting as well as to methods of modulating expression of target genes in a cell.
US08470971B2 Cell permeable p53 recombinant protein, polynucleotide encoding the same, and anti-cancer composition containing the same as active ingredient
Disclosed are a cell-permeable p53 recombinant protein in which a macromolecule transduction domain (MTD) is fused to the tumor suppressor p53, a polynucleotide encoding the same, a recombinant expression vector for producing the same, and a pharmaceutical composition of the treatment of cancer, comprising the same. Having high cell permeability, the p53 recombinant protein is effectively transduced into cells so that the tumor suppressor p53 can be translocated into cell nuclei. Within nuclei, p53 inhibits the formation of cyclin-CDK complexes to halt the cell cycle, thus suppressing excessive cell proliferation and inducing apoptosis of tumor cells. Therefore, the p53 recombinant protein can be useful as an anticancer agent in the treatment of various cancers.
US08470969B2 Apo-2 ligand/trail formulations
The present invention relates generally to Apo2L/TRAIL purification involving crystallization.
US08470968B2 SPARC-derived tumor rejection antigenic peptides and medicaments comprising the same
It is an objective of the present invention to identify SPARC protein-derived peptides that are able to induce human killer T cells and helper T cells having cytotoxic activity to tumors, and to provide a means for carrying out a tumor immunotherapy of patients with various types of cancers overexpressing SPARC. The present invention provides a peptide of any of the following: (A) a peptide which consists of the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3; or (B) a peptide which consists of an amino acid sequence comprising a substitution or addition of one or several amino acids with respect to the peptide consisting of the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3, and which has capacity to induce cytotoxic (killer) T cells.
US08470967B2 Phase transition biopolymers and methods of use
The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. The polypeptides may be used to deliver therapeutics to a biological site and to develop bioactive polypeptides that are environmentally responsive.
US08470966B2 Universal fibronectin type III binding-domain libraries
Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having high binding affinities, e.g., greater than 300 nM, for VEGFR2 or Axl proteins.
US08470965B2 Methods and compositions related to cyclic peptide synthesis
Disclosed are compositions and methods for prenylation of polymers such as peptides.
US08470964B2 Peptides derived from NCAM (FGLs)
The present invention relates to novel compounds comprising at most 13 contiguous amino acid residues derived from the fibronectin type 3,11 module of neural cell adhesion molecule (NCAM), or a variant or fragment thereof, capable of interacting with an FGFR and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity or survival of cells. Further, the present invention relates to the use of the compounds for production of a medicament for treatment of conditions and diseases, in which NCAM or FGFR play a prominent role.
US08470963B2 Multifunctional compounds for pharmaceutical purposes
The invention relates to a synthetic bifunctional non-antibody compound comprising one or more effector moieties and one or more binder moieties, wherein the effector moieties are operably linked to the binder moieties via a linker, the effector moieties are ligands to at least one pathogen pattern recognition receptor (PRR) and the binder moieties bind to a marker of a tumor cell.
US08470962B2 Method of thermoforming copolyesters
A method of preventing bubble formation during or after thermoforming polyester sheet comprising heating the polyester sheet to about 100-165° F. for at least about 1 hour prior to thermoforming the sheet.
US08470959B2 Polyimide compound, preparation method therefor, and optical film and optical waveguide produced by employing the compound
A novel polyimide compound which has a low linear expansion coefficient and permits film formation by a spin coating method or the like, a preparation method for the polyimide compound, and an optical film and an optical waveguide produced by employing the compound. The polyimide compound has a structural unit represented by the following general formula (1): wherein X is a covalent single bond, —CH2—, —C(CF3)2— or —CR(R′)— (wherein R and R′, which may be the same or different, are each a C1 to C6 alkyl group or an aryl group); A and B, which may be the same or different, are substituents each selected from a hydroxyl group, a halogen group and a C1 to C4 alkyl group; a and b, which are the numbers of the substituents A and B, respectively, are each an integer of 0 to 2; and o, p and q are each an integer of 1 to 5.
US08470958B1 Antibiotic-bound poly(caprolactone) polymer
This invention is the design and synthesis of a caprolactone monomer which bears a pendant protected carboxyl group. This monomer has been copolymerized with caprolactone in varying ratios. After polymerization, the protecting group can be removed and an antibiotic can be attached as a new pendant group. The bioactivity of the antibiotic-bound poly(caprolactone) polymer is described.
US08470956B2 Polycarbonate polyol compositions and methods
In one aspect, the present disclosure encompasses polymerization systems for the copolymerization of CO2 and epoxides comprising 1) a catalyst including a metal coordination compound having a permanent ligand set and at least one ligand that is a polymerization initiator, and 2) a chain transfer agent having two or more sites that can initiate polymerization. In a second aspect, the present disclosure encompasses methods for the synthesis of polycarbonate polyols using the inventive polymerization systems. In a third aspect, the present disclosure encompasses polycarbonate polyol compositions characterized in that the polymer chains have a high percentage of —OH end groups and a high percentage of carbonate linkages. The compositions are further characterized in that they contain polymer chains having an embedded polyfunctional moiety linked to a plurality of individual polycarbonate chains.
US08470954B2 Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant
A novel macromer or mixture thereof is described herein, comprising benzoyl isocyanate terminal moieties and at least two residues of a water-soluble polymer having a molecular weight ranging from 80 to 10,000 adjacent to the carbonyl group of the benzoyl isocyanate moieties, thereby forming at least two ester linkages in the macromer or mixture thereof. A method for making a polyisocyanate macromer is also described herein.
US08470952B2 Composition for thermosetting silicone resin
The present invention relates to a composition for a thermosetting silicone resin, the composition including: (1) a dual-end silanol type silicone oil; (2) an alkenyl group-containing dialkoxyalkylsilane; (3) an organohydrogensiloxane; (4) a condensation catalyst; and (5) a hydrosilylation catalyst.
US08470950B2 Method for sealing and assembling components of a drive train
A method is described for sealing and assembling components of a drive train by means of silicon elastomers prepared using silicon compositions that do not contain any metal catalyst such as, for example, tin, and cross-linking by polycondensation reactions in the presence of water (for example, ambient moisture).
US08470945B2 Polymerisable mass with cross-linking nanoparticles
The invention provides a polymerizable composition which comprises: a) acrylates and/or methacrylates, b) 0.05% to 70% by weight of SiO2 particles having an average particle size of 1 to 30 nm which have polymerizable groups of the methacryloyl, acryloyl, styryl, itaconyl, crotonyl, vinyl, allyl and/or alkenyl type on the surface and are present in dispersion in the acrylates and/or methacrylates, at least 50% of the SiO2 particles consisting of individual, unaggregated or unagglomerated primary particles, c) not more than 2% by weight of crosslinker molecules.
US08470943B2 Solid polymer electrolyte material, liquid composition, solid polymer fuel cell and fluoropolymer
A solid polymer electrolyte material made of a copolymer comprising a repeating unit based on a fluoromonomer A which gives a polymer having an alicyclic structure in its main chain by radical polymerization, and a repeating unit based on a fluoromonomer B of the following formula (1): CF2═CF(Rf)jSO2X  (1) wherein j is 0 or 1, X is a fluorine atom, a chlorine atom or OM {wherein M is a hydrogen atom, an alkali metal atom or a group of NR1R2R3R4 (wherein each of R1, R2, R3 and R4 which may be the same or different, is a hydrogen atom or a monovalent organic group)}, and Rf is a C1-20 polyfluoroalkylene group having a straight chain or branched structure which may contain ether oxygen atoms.
US08470942B2 Method for producing melt-moldable tetrafluoroethylene copolymer
The claimed invention relates to a method for producing a melt-moldable tetrafluoroethylene copolymer containing repeating units (a) based on tetrafluoroethylene and repeating units (b) based on another fluoromonomer, wherein the amount of the repeating units (a), based on the total mass of the repeating units (a) and the repeating units (b), is from 97.3 to 99.5 mass %, and the volume flow rate of the copolymer is from 0.1 to 1000 mm3/s; the process including radical suspension-polymerization of tetrafluoroethylene and the fluoromonomer in an aqueous medium in the presence of a radical polymerization initiator and at least one chain transfer agent selected from the group consisting of methane, ethane, a hydrochlorocarbon, a hydrofluorocarbon and a hydrochlorofluorocarbon.
US08470936B2 Liquid epoxy resin composition for semiconductor encapsulation
A liquid epoxy resin composition for semiconductor encapsulation comprising: (A) at least one epoxy resin, (B) at least one curing accelerator and (C) at least one acid anhydride terminated polyamic acid. The liquid epoxy resin composition provides a cured material that has an excellent adhesiveness to a semiconductor chip surface and has an excellent moisture resistance.
US08470935B2 Shape-memory resin, molded product composed of the resin, and method of using the molded product
There are provided: a shape-memory resin, which is formed from a polylactic acid derivative thereby enabling reduction of an environmental load, has an excellent shape-memory property, high strength, and high toughness, and with which a molded product with high durability, for example, an electronic equipments, particularly a wearable electronic equipments capable of freely changing the shape thereof or the like, can be shaped; and a molded product thereof. The shape-memory resin of the present invention has a three-dimensional structure, in which a polylactic acid derivative having two or more functional groups capable of forming a cross-linking site is cross-linked using a flexible polymer having a glass transition temperature (Tg) lower than 30° C. and having two or more functional groups capable of forming a cross-linking site, and a linker.
US08470933B2 Coating for leak detection and method
A coating is used to detect a fluid leak.
US08470932B2 Scalable process for synthesis of a curable wax
The methods of manufacturing a curable wax, such as an acrylate of a hydroxyl-terminated polyethylene wax having the structure CH3—(CH2)n—CH2OH, where n=22-24, are disclosed. The methods may include reacting a wax having a transformable functional group and a curable compound in the presence of an organic solvent to form an acrylate. The methods may further include removing excess curable compound using hot water having a temperature of more than 85° C., and solidifying the acrylate. The methods may thereby provide safe and cost effective methods for curable wax production at large scale.
US08470930B2 Novolak resins and rubber compositions comprising the same
The present invention relates to novolak resins prepared with, inter alia, one or more alkylphenols. The invention further relates to compositions comprising the novolak resins, such as vulcanizable rubber compositions, and to products obtained therewith.
US08470929B2 Composition for stretchable film
Provided is a composition for a stretchable film, which achieves a high-level balance between a high elastic modulus and a small permanent set, and can be formed into a stretchable film with satisfactory formability. A composition for a stretchable film comprises a block copolymer composition containing a block copolymer A represented by the following general formula (A) and a block copolymer B represented by the following general formula (B), and a tackifier resin: Ar1a-Da-Ar2a   (A) (Arb-Db)n-X   (B), in the general formulas (A) and (B), Ar1a and Arb each represent an aromatic vinyl polymer block having a weight average molecular weight of 6,000 to 20,000; Ar2a represents an aromatic vinyl polymer block having a weight average molecular weight of 40,000 to 400,000; Da and Db each represent a conjugated diene polymer block having a vinyl bond content of 1 mol % to 20 mol %; X represents a single bond or a residue of a coupling agent; and n represents an integer of 2 or greater.
US08470923B2 Composite material for structural applications
Composite material that contain epoxy resin which is toughened and strengthened with thermoplastic materials and a blend insoluble particles. The uncured matrix resins include an epoxy resin component, a soluble thermoplastic component, a curing agent and an insoluble particulate component composed of elastic particles and rigid particles. The uncured resin matrix is combined with a fibrous reinforcement and cured/molded to form composite materials that may be used for structural applications, such as primary structures in aircraft.
US08470921B2 Ultra-low permeability polymeric encapsulated acoustic device and method
This invention is an acoustic device protected by an acoustically transparent low water permeability encapsulant made from an acoustically clear polymer such as polyurethane. High aspect ratio clay nanoparticles are positioned in the substrate in overlapping layers with layers of the substrate interposed. The invention also provides a method for forming an acoustically transparent low permeability encapsulant about an acoustic device. The method includes treating high aspect ration clay nanoparticles to make them organophilic. The treated nanoparticles are then mixed in a polymer resin in such a way as to form an intercalated mixture. A curing agent is added to the mixture, and the mixture is allowed to set. When set the resulting intercalated mixture produces an acoustically clear, low permeability polymer coating.
US08470919B2 Flame retardant polyethylene composition comprising polypropylene
The present invention relates to a flame retardant polymer composition comprising (A) a polyethylene, (B) a silicone-group containing compound, (C) an inorganic filler material, and (D) a polypropylene in an amount of 0.1 to 10 wt. % with respect to the total composition, to an article comprising said flame retardant polymer composition, in particular to a wire or cable comprising a layer made of said flame retardant composition and to the use of said flame retardant polymer composition for the production of a layer of a wire or cable. Furthermore, the invention relates to the use of a polypropylene in the production of a flame retardant layer for a wire or cable as a processing aid.
US08470914B2 Photosensitive polyimide and photosensitive resin composition comprising the same
The present invention relates to polyimide or precursor thereof represented by Chemical Formula 1 or 2 and a photosensitive resin composition including the same. The polyimide or precursor thereof are fabricated using diamine comprising polyalkyleneoxide. The photosensitive resin composition of the present invention has excellent light transmissivity, an excellent resolution, and excellent photo sensitivity and image forming performance. Further, the photosensitive resin composition has high adhesiveness with substrates, such as a silicon film, a silicon oxide film, and a metal film. In particular, an excellent film without failure, such as crack, can be formed.
US08470908B2 Use of polymer isoacetals in printing ink formulations
Printing ink formulations containing polyvinyl isoacetals as a binder component exhibit lower solution viscosity and higher binder Tg, allowing use of more binder and more pigment, thus increasing depth of color and printing speed, as well as lowering the risk of delamination and ruboff.
US08470899B2 Silicone composition which is cross-linkable by dehydrogenative condensation in the presence of a non-metal catalyst
A silicone composition is described that includes components having SiH/SiOH groupings and that can be polymerized/cross-linked by a dehydrogenative condensation reaction in the presence of a non-metal tri- or tetrasubstituted non-silylated guanidine catalyst and requiring a low activation temperature.
US08470898B2 Methods of making lithium ion battery separators
A porous thin-film polymer separator for use in a lithium ion battery may be formed by a phase separation method in which hydrophobic-treated ceramic particles are used to help induce the formation of a tortuous, interconnected network of pores coextensively across the thickness of the separator. As part of the phase separation method, a wet thin-film layer is formed from a polymer slurry that comprises a polymer solvent in which a polymer material is dissolved and the hydrophobic-treated ceramic particles are dispersed. The wet thin-film layer is subsequently exposed to a polymer non-solvent to form a solvent-exchanged thin-film precipitated polymer layer which is then heated to produce the separator.
US08470892B2 Method of inducing neovascularization
A method for inducing neovascularization in which a pharmaceutically effective amount of polyethylene glycol (PEG) is injected into the tissue of the subject for purposes of accelerating wound healing and mimicking age related macular degeneration, cancer, tumors, and atherosclerosis for further research purposes.
US08470891B2 Biodegradable block polymers for drug delivery, and methods related thereto
A biodegradable block copolymer is disclosed, comprising a hydrophilic block derived from a polyether alcohol; and a hydrophobic block comprising a first repeat unit derived by ring opening polymerization of a first cyclic carbonyl monomer initiated by the polyether alcohol, the first repeat unit comprising a side chain moiety comprising a functional group selected from the group consisting of i) urea groups and ii) mixtures of urea groups and carboxylic acid groups. No side chain of the hydrophobic block comprises a covalently bound biologically active material. The block copolymer self-assembles in water forming micelles suitable for sequestering a biologically active material by a non-covalent interaction, and the block copolymer is 60% biodegraded within 180 days in accordance with ASTM D6400.
US08470889B2 Hybrid-ionone and curcumin molecules as anticancer agents
The present invention relates to the synthesis of a series of ionone and curcumin derivatives as multi-targeting agents effective against both hormone-sensitive and hormone-independent cancers. In particular, the present invention is directed to a distinct class of bifunctional antiandrogens, which inhibit both AR and IKBkinases (IKK). A series of ionone-based chalcones were synthesized and their in vitro cytotoxicity against prostate cancer cell lines were demonstrated. A series of derivatives formed by reacting ionone-based chalcones and hydrazines demonstrate substantial antiproliferative activities in prostate cancer, breast cancer and lung cancer cell lines.
US08470886B2 Topical ibuprofen formulations
The present application relates to a topical formulation comprising ibuprofen, a hydroalcoholic based solvent system, a C1-4alcohol ester of citric acid, and a surfactant. The formulation shows physical stability over more than one month at ambient temperature and is colorless, essentially odorless, and has a pH value of about 6.5. The formulation of the application shows two to four times improved ibuprofen flux compared to a standard composition.
US08470879B2 Fatty acid inhibitors
Fatty acid inhibitors, pharmaceutical compositions including fatty acid inhibitors, methods for using fatty acid inhibitors to treat a variety of diseases, and methods for preparing fatty acid inhibitors are provided herein.
US08470876B2 Lipid composition for the treatment of skin problems in companion animals
The present invention provides lipid compositions comprising linolenic acid (LA), alpha-linolenic acid (ALA), stearidonic acid (SDA) and gamma linolenic acid (GLA), said LA and ALA in a ratio of about less than 2:1 LA:ALA. The compositions find use in for improving, treating, or preventing a condition selected from the group consisting of: eczema, dry skin, flaky skin, pruritus, pyotraumatic dermatitis, furunculosis, dry paw pads, rough paw pads, chapped paw pads, paw pad durability, dry rhinarium, chapped rhinarium, split claws, brittle claws, rashes, hairless spots, hot spots, symmetrical lupoid onychodystrophy, skin ulceration, skin crusting, reddening of skin between toes, external ear infection, and nutritional dermatosis.
US08470875B2 Use of parthenolide derivatives as antileukemic and cytotoxic agents
The present invention provides compounds of the formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof.
US08470874B2 Pharmaceutical compositions comprising cannabichromene type compounds
The invention relates to the use of cannabichromene type compounds and derivatives thereof in the treatment of mood disorders.
US08470868B2 Formulation for the prevention of cardiovascular disease
This invention relates to a method for the prevention of cardiovascular disease, a formulation for the prevention of cardiovascular disease, the use of specified active principals for the manufacture of such a formulation for use in the method and to a method of preparing said formulation. The formulation of the present invention is a combination of active principals for use in the prevention of cardiovascular disease, notably ischaemic heart disease (including heart attacks) and stroke among the general adult population.
US08470867B2 Sigma receptor inhibitors
The invention relates to compounds of formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
US08470861B2 Mitochondria-targeted antioxidant prodrugs and methods of use
The present invention is a mitochondria-targeted antioxidant prodrug useful for the prevention or treatment of diseases or conditions associated with mitochondrial dysfunction resulting from changes in the mitochondrial redox environment. Antioxidant prodrugs of the invention are produced by modifying an antioxidant to a fatty acid so that the resulting prodrug is targeted to and activated by an enzyme of mitochondrial fatty acid beta-oxidation.
US08470859B2 Iminopyridine derivative and use thereof
Provided are an iminopyridine derivative having a selective α1D adrenergic receptor antagonistic action and useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like, and a screening method for a compound having an α1D adrenergic receptor antagonistic action. An α1D adrenergic receptor antagonist containing a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof, and a method of screening for an agent having an α1D adrenergic receptor antagonistic action for the prophylaxis or treatment of a lower urinary tract disease, which includes measuring the bladder smooth muscle tension of rats with bladder outlet obstruction.
US08470857B2 Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents
The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
US08470853B2 Transdermal methods and systems for the delivery of anti-migraine compounds
Iontophoretic patches for the delivery of anti-migraine compounds and methods of using the patches are described.
US08470851B2 Substituted acetylenic imidazo[1,2-A]pyridine compounds as kinase inhibitors
This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
US08470850B2 Inhibitors of VEGF receptor and HGF receptor signalling
The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions
US08470848B2 Organic compounds
There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
US08470843B2 Azacyclic compounds
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3 and A are as described herein, compositions including the compounds and methods of using the compounds.
US08470841B2 Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
Heterocyclic derivatives, processes for their preparation, medicaments comprising these compounds, and the use thereof. The invention relates to compounds of the formula I in which the radicals R1, R2, R3, R4, W, A, B, D, E, G, L, M, R, T and Y have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example for the treatment of the metabolic syndrome, insulin resistance, obesity and diabetes.
US08470838B2 Methods and compositions utilizing quinazolinones
Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
US08470835B2 Pyrimidinecarboxamide derivatives as inhibitors of Syk kinase
The present invention relates to the compound of formula (I): or a salt, preferably a pharmaceutically acceptable salt, thereof; is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate mast cell activation, for instance allergic and inflammatory diseases, as well of potential use in cancer therapy, specifically heme malignancies.
US08470834B2 AZO-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
The present invention provides compounds of Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19, and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
US08470833B2 Hair growth and/or regrowth compositions
The present disclosure relates to compositions containing certain pyrimidine compounds such as minoxidil and/or certain pyrimidine sulfate (inner salt) compounds such as minoxidil sulfate and especially compositions containing pyrimidine compounds in combination with an admixtures comprising at least one antioxidant, at least one organic acid and a select fatty acid mixture. The present disclosure also relates to use of the compositions to grow and/or regrow hair and/or prevent hair loss in mammals and particularly in humans.
US08470831B2 Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition
Acrylamido derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of the mitochondrial permeability transition pore (MPTP), such as the diseases characterized by ischemia/reperfusion, oxidative or degenerative tissue damage, are herein described. These compounds belong to the structural formula (I) wherein R, R′, R″, W and a are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to pharmaceutical compositions comprising them.
US08470825B2 Diazabenzo[de] anthracen-3-one compounds and methods for inhibiting PARP
The present invention relates to diazabenzo[de]anthracen-3-one compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
US08470816B2 Nitrogen-containing heterocyclic compound and use thereof
The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle optionally further having substituent(s), ring B is an aromatic ring optionally having substituent(s), ring C is a cyclic group optionally having substituent(s), R1 is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group, a heterocyclic group optionally having substituent(s) or an amino group optionally having substituent(s), R2 is an optionally halogenated C1-6 alkyl group, m and n are each an integer of 0 to 5, m+n is an integer of 2 to 5, and is a single bond or a double bond, or a salt thereof and the like. Since the compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, gastrointestinal diseases, central nervous system diseases and the like.
US08470815B2 Nitrofuran compounds for the treatment of cancer and angiogenesis
The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.
US08470812B2 Substituted benzo-pyrimido-tetrazolo-diazepine compounds
The present invention relates to substituted benzo-pyrimido-tetrazolo-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-pyrimido-tetrazolo-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
US08470811B2 Substituted heterocyclylbenzylpyrazoles and use thereof
The present application relates to novel substituted 1-[3-(heterocyclyl)benzyl]-1H-pyrazole derivatives, to processes for preparation thereof, to use thereof for treatment and/or prevention of diseases and to use thereof for production of medicaments for treatment and/or prevention of diseases, more particularly for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be effected in the form of monotherapy or else in combination with other medicaments or further therapeutic measures.
US08470810B2 Heterocyclic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
The invention relates to compounds of the formula (I) wherein n is 0, 1 or 2; G is CH2 or CHR3; R1 is H, C,-C6-alkyl, C,-C6-alkyl substituted by C3-C6-cycloalkyl, C1-C6-hydroxyalkyl, fluorinated C,-C6-alkyl, C3-C6-cycloalkyl, fluorinated C3-C6-cycloalkyl, C3-C6 alkenyl, fluorinated C3-C6-alkenyl, formyl, acetyl or propionyl; R2, R3 and R4 are, independently of each other, H, methyl, fluoromethyl, difluoromethyl, or trifluoromethyl; A is phenylene, pyridylene, pyrimidylene, pyrazinylene, pyridazinylene or thiophenylene, which can be substituted by one or more substituents selected from halogen, methyl, methoxy and CF3; E is NR5 or CH2, wherein R5 is H or C1-C3-alkyl; Ar is a cyclic radical selected from the group consisting of phenyl, a 5- or 6-membered heteroaromatic radical comprising as ring members 1, 2 or 3 heteroatoms selected from N, O and S and a phenyl ring fused to a saturated or unsaturated 5- or 6-membered carbocyclic or heterocyclic ring, where the heterocyclic ring comprises as ring members 1, 2 or 3 heteroatoms selected from N, O and S and/or 1, 2 or 3 heteroatom-containing groups each independently selected from NR8, where R8 is H, C1-C4-alkyl, fluorinated C1-C4-alkyl, C1-C4alkylcarbonyl or fluorinated C1-C4-alkylcarbonyl, and where the cyclic radical Ar may carry 1, 2 or 3 substituents Ra, wherein the variable Ra has the meanings given in the claims and in the description; and physiologically tolerated acid addition salts thereof. The invention also relates to the use of a compound of the formula I or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.
US08470805B2 Processes for preparing piperazinium salts of KMUP and use thereof
A series of monoquarternary piperazium salts including a structure of a formula I or II are provided. In formula I or II, R1, Ra, and RX are as defined in the specification. The monoquarternary piperazium salt of KMUP or piperazine disclosed in the present invention is characterized by being presented in a pro-drug form and having various pharmaceutical functions.
US08470803B2 Boron-containing small molecules
This invention provides, among other things, novel compounds useful for treating inflammatory conditions, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
US08470801B2 Myocardial perfusion imaging methods and compositions
A myocardial imaging method that is accomplished by administering one or more adenosine A2A adenosine receptor agonist to a human undergoing myocardial imaging as well as pharmaceutical compositions comprising at least one A2a receptor agonist, at least one liquid carrier, and at least one co-solvent.
US08470800B2 Method of reducing intraocular pressure in humans
Provided herein are compounds, compositions, and methods for reducing intraocular pressure. Also provided herein are compounds, compositions and methods for the treatment of glaucoma or ocular hypertension.
US08470796B2 Treatment of cancer by inhibition of IGFBPs and clusterin
Agents that reduce the amount of IGFBP-2 and/or IGFBP-5 and that are known to be useful in the treatment of cancer result in increased expression of the protein clusterin. Since clusterin can provide protection against apoptosis, this secondary effect detracts from the efficacy of the therapeutic agent. In overcoming this, the present invention provides a combination of therapeutic agents that is useful in the treatment of cancer. The combination includes an agent that reduces the amount of IGFBP-2 and/or IGFBP-5 and that stimulates expression of clusterin as a secondary effect, and an oligonucleotide that is effective to reduce the amount of clusterin in cancer cells. In some embodiments of the invention, the agent that reduces IGFBP-2 and/or IGFBP-5 is a bispecific antisense species. The oligonucleotide may be an antisense oligonucleotide or an RNAi oligonucleotide.
US08470794B2 Increasing erythropoietin using nucleic acids hybridizable to micro-RNA and precursors thereof
Methods and compositions relating to nucleic acids targeting certain miRNA molecules are disclosed. The nucleic acids are useful, for example, in methods of increasing the expression and/or secretion of EPO and treating various disease states including anemia, hemophilia, and/or sickle cell disease.
US08470785B2 Method for treating ocular cancer
Compositions and methods for treating ocular cancer are provided. The composition is a subconjunctival formulation of nutlin-3 and its analogs. The composition provides for methods of treating ocular cancer, including retinoblastoma. The formulation has high penetration into ocular tissue with low toxicity.
US08470782B2 Transglutaminase inhibitors and methods of use thereof
Transglutaminase inhibitors and methods of use thereof are provided.
US08470777B2 Pregnancy-induced oligodendrocyte precursor cell proliferation regulated by prolactin
The present invention relates to a method to increase oligodendrocytes and oligodendrocyte precursor cells through administration of prolactin or a prolactin inducing agent.
US08470775B2 Compositions and methods for reducing the risk of preeclampsia
Methods and kits for preventing or reducing the likelihood of implantation failure or miscarriage in a recipient of artificial insemination are provided. The methods include administering into a recipient of artificial insemination in need of such treatment an effective amount of granulocyte colony stimulating factor (G-CSF).
US08470766B2 Protein kinase C therapy for the treatment of acute lung injury
The present invention provides novel formulations of a δPKC inhibitor. The δPKC inhibitor can be, for example, a peptide. The present invention also discloses a method of preventing acute pulmonary cell injury associated with trauma, ALI or ARDS and a method of inhibiting an inflammatory response in pulmonary cells by inhibiting the activity of δPKC. The invention also provides a method of treating a pulmonary disease with an aerosol formulation of a δPKC inhibitor to inhibit neutrophil activity.
US08470758B2 Detergent compositions and methods of use for an alpha-amylase polypeptide of bacillus species 195
Disclosed herein are compositions comprising an alpha-amylase enzyme obtained from Bacillus sp. no. 195, and methods of using the enzyme to clean surfaces and textiles. Also disclosed are variants of the enzyme with different signal sequences.
US08470755B1 Liquid cleaning and disinfecting compositions comprising a zinc inorganic salt
The present invention relates to cleaning and disinfecting liquid detergent compositions and, in one embodiment, liquid hand dishwashing compositions, comprising a metal salt, preferably a divalent metal salt, preferably Zn2+-salt and linear alkyl nucleophilic surfactant, preferably a linear alkyl chain amine oxide.The present invention further relates to methods of disinfecting dishware and/or dishwashing implements and/or skin using such a liquid detergent compositions.
US08470753B2 Personal cleansing systems exhibiting low eye irritation potential
An ethylene oxide-free, dioxane-free, and formaldehyde-free personal care concentrate composition free of ethoxylated components which is non-irritating to eyes comprising water, sodium alkyl sulfate, propanediol, and a synthetic amphoteric surfactant selected from the group consisting of cocamidopropyl hydroxysultaine and cocamidopropyl betaine is disclosed. This composition is especially suitable for baby shampoos which are not irritating. In some embodiments the composition is free of formaldehyde.
US08470752B2 Automotive lubricant composition
Lubricant compositions for use in automotive engine oils comprising a combination of a specific base stock or mixture of base stocks and a friction reducing additive to improve fuel economy and fuel economy longevity of the automotive engine oil. The friction reducing additive is a specific partial polyol ester and may also include a specific saturated primary amide.
US08470749B2 Method of preparing an overbased or neutral detergent
The invention provides a process for preparing a neutral or an overbased detergent, the process by: reacting (a) a pre-prepared suspension comprising (i) a metal base with a mean particle size of 10 micrometers or less; (ii) a surfactant; and (iii) an organic medium in which the metal base is suspended typically by a physical process. An overbased detergent may be formed with a further reaction with acidifying overbasing agent. The invention further provides a lubricant composition containing said neutral and overbased detergent.
US08470748B2 Electroconductive grease
Disclosed is an electroconductive grease comprising a fluorine oil, an electroconductive material, and a thickening agent, the electroconductive grease containing 5 to 20 wt. % of carbon black having a DBP oil absorption amount of 250 ml/100 g or less as the electroconductive material, and 2 to 15 wt. % of fluorine-containing resin particles having an average primary particle size of 1.0 μm or less as the thickening agent. The electroconductive grease comprises carbon black having specific properties, and fluorine-containing resin particles, preferably PTFE particles, having an average primary particle size of 1.0 μm or less, and therefore exhibits excellent oil separation characteristics, namely, a remarkably lower degree of oil separation, which can also be reduced to 10 wt. % or less.
US08470747B2 Carboxylic acid and oxidizer clean-up compositions and associated methods of use in subterranean applications
Of the many methods provided herein, one method of reducing the viscosity of a viscosified treatment fluid includes: providing a clean-up composition comprising a carboxylic acid; providing a chlorite-based breaker system; providing a viscosified treatment fluid; placing the viscosified treatment fluid in a subterranean formation via a well bore penetrating the subterranean formation; contacting the viscosified treatment fluid with the clean-up composition; contacting the viscosified treatment fluid with the chlorite-based breaker; and allowing the viscosity of the viscosified treatment fluid to reduce. Also provided herein are methods that include a method of reducing polymeric residue from a subterranean formation that includes: placing a clean-up composition and a chlorite-based breaker system in a subterranean formation in contact with an amount of polymeric residue; and allowing the amount of polymeric residue present in the formation to be reduced.
US08470746B2 Methods relating to the stabilization of hydrophobically modified hydrophilic polymer treatment fluids under alkaline conditions
The present invention relates to methods and compositions for treating a water- and hydrocarbon-producing subterranean formation with a relative permeability modifier, and more specifically, to improved treatment fluids, methods for preparing treatment fluids, and methods for use thereof in a subterranean formation. Methods of the present invention comprise providing a treatment fluid comprising a relative permeability modifier, at least one surfactant, and an aqueous phase base fluid; and placing the treatment fluid in a subterranean formation. The relative permeability modifier comprises a hydrophobically modified hydrophilic polymer. The at least one surfactant is operable to maintain the relative permeability modifier in a dissolved state in the treatment fluid above a pH of about 8.
US08470745B2 Methods and compositions for obtaining and using biologically active multi-protein complexes
Methods for isolating and using multi-protein complexes that are biologically active are provided. The complexes contain one or more proteins of interest (e.g. a receptor, ion channel, etc.) and associates scaffolding proteins such as phosphatases, kinases and post synaptic density components. Buffers that do not contain denaturing agents and which may be used to isolate the multi-protein complexes are also provided, as are protein arrays containing the biologically active multi-protein complexes. The protein arrays may be used, for example, for high throughput screening assays.
US08470742B2 Homogeneous liquid saccharide and oil systems
Oil based emulsifiable concentrates containing a liquid saccharide including a) at least one oil component; b) at least one saccharide, particularly a liquid saccharide solution (LS); c) and at least one non-ionic surfactant. The concentrate may also contain at least one of d) at least one surfactant hydrocarbyl saccharide; or e) at least one anionic surfactant; or f) at least one additional oil soluble non-ionic surfactant. The concentrates are typically homogeneous for at least 24 hours and emulsify readily on dilution into water. The concentrates may also contain an antifoaming agent especially a polysiloxane. Upon dilution in water, the emulsions formed from the concentrates are applied to substrates in combination with agrochemically active ingredients, preferably N-phosphonomethylglycine in the form of its soluble salts, to control weeds.
US08470740B2 Flowering stimulant composition using nitrobenzene
A flowering stimulant composition with Nitrobenzene for Agricultural and Horticultural flowering crops including Nitrobenzene as an Active ingredient, with Natural/Synthetic/Ionic (or) Non Ionic chemical surfactant and base with petro (or) Non petro solvent base. A typical example of 100 kg of the composition has 5 to 10 kgs. of Linear alkyl Benzene (Acid slurry), 1 to 2 kgs. of Sodium Hydroxide, 2 to 4 kgs. of Urea, 20 kg of Nitro Benzene and Quantum sufficientum Filler & stabilizer. In the case of 100 kgs. of granular formulation, the composition has 75 kg or 80 kg of Roasted or unroasted Bentonite clay or silica quartz sand granules, 10 kg or 15 kg Nitrobenzene and Quantum sufficientum Coating agent and De-activating Chemicals.
US08470739B2 Isothiazolyloxyphenylamidines and their use as fungicides
The present invention relates to isothiazolyloxyphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms, and also to a composition for this purpose which comprises the isothiazolyloxyphenylamidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or in their habitat.
US08470727B2 Metal carboxylate clays, derivatives of metal carboxylate clays, methods for making the same, and compositions containing the same
Zinc carboxylate clays and zinc carboxylate organoclays, methods for their preparation, and compositions containing the same are disclosed. The methods comprise either mixing a zinc clay composition with a carboxylic acid, or mixing a carboxylic acid with a zinc ammonia complex solution, then combining the resulting zinc carboxylate salt with a slurry or suspension of a cation-exchangeable clay, to prepare the zinc carboxylate clay. These clays can be further intercalated with quaternary ammonium salts to make zinc carboxylate organoclays. The present clays may be used in compositions and/or as additives in rubber and plastic formulations and products and in catalyst formulations.
US08470722B2 Breathable waterproof fabrics with a dyed and welded microporous layer
A composite wind barrier fabric having the ability to maintain a high MVTR while controlling air permeability. The fabric has a nanofiber layer optionally welded to, and in a face-to-face relationship with, a fabric layer. Optionally a second fabric layer is welded adjacent to and in a face-to-face relationship with the nanofiber layer and on the opposite side of the nanofiber layer to the first fabric layer. The fabric has a Frazier air permeability of between about 1.2 m3/m2/min and about 7.6 m3/m2/min, and an MVTR per ASTM E-96B method of greater than about 500 g/m2/day. The nanofiber layer is dyed over at least a portion or all of its surface or both.
US08470721B2 Magnetic processing of operating electronic materials
The electronic properties (such as electron mobility, resistivity, etc.) of an electronic material in operation in an electronic device or electronic circuit can be modified/enhanced when subjected to dynamic or stationary magnetic fields with current flowing through the electronic material. Heating or cooling of the electronic material further enhances the electronic properties.
US08470718B2 Vapor deposition reactor for forming thin film
A vapor deposition reactor includes a chamber filled with a first material, and at least one reaction module in the chamber. The reaction module may be configured to make a substrate pass the reaction module through a relative motion between the substrate and the reaction module. The reaction module may include an injection unit for injecting a second material to the substrate. A method for forming thin film includes positioning a substrate in a chamber, filling a first material in the chamber, moving the substrate relative to a reaction module in the chamber, and injecting a second material to the substrate while the substrate passes the reaction module.
US08470712B2 Process for the transfer of a thin film comprising an inclusion creation step
A process for transferring a thin film includes forming a layer of inclusions to create traps for gaseous compounds. The inclusions can be in the form of one or more implanted regions that function as confinement layers configured to trap implanted species. Further, the inclusions can be in the form of one or more layers deposited by a chemical vapor deposition, epitaxial growth, ion sputtering, or a stressed region or layer formed by any of the aforementioned processes. The inclusions can also be a region formed by heat treatment of an initial support or by heat treatment of a layer formed by any of the aforementioned processes, or by etching cavities in a layer. In a subsequent step, gaseous compounds are introduced into the layer of inclusions to form micro-cavities that form a fracture plane along which the thin film can be separated from a remainder of the substrate.
US08470709B2 Formation of metal-containing nano-particles for use as catalysts for carbon nanotube synthesis
The present invention relates to a method for forming metal-silicide catalyst nanoparticles with controllable diameter. The method according to embodiments of the invention leads to the formation of ‘active’ metal-suicide catalyst nanoparticles, with which is meant that they are suitable to be used as a catalyst in carbon nanotube growth. The nano-particles are formed on the surface of a substrate or in case the substrate is a porous substrate within the surface of the inner pores of a substrate. The metal-silicide nanoparticles can be Co-silicide, Ni-silicide or Fe-silicide particles. The present invention relates also to a method to form carbon nanotubes (CNT) on metal-silicide nanoparticles, the metal-silicide containing particles hereby acting as catalyst during the growth process, e.g. during the chemical vapor deposition (CVD) process. Starting from very defined metal-containing nanoparticles as catalysts, the diameter of grown CNT can be well controlled and a homogeneous set of CNT will be obtained.
US08470705B2 Chip pad resistant to antenna effect and method
A chip pad structure of an integrated circuit (IC) and the method of forming are disclosed. The chip pad comprises a main pad portion and a ring pad portion. During a charging process involved in forming the chip pad structure, electrical connections from the gate electrodes of MOS transistors in the IC substrate generally are made only to the ring pad portion that has an antenna-to-gate area ratio substantially below a predetermined antenna design rule ratio, and thus is resistant or immune to antenna effect. The main pad portion and the ring pad portion are coupled together through metal bridges formed in an upper interconnect metal layer or in the top conductive pad layer. The chip pad may be used as probe pads on a parametric testline or bonding pads on an IC.
US08470700B2 Semiconductor device with reduced contact resistance and method of manufacturing thereof
A method (and semiconductor device) of fabricating a semiconductor device provides a filed effect transistor (FET) with reduced contact resistance (and series resistance) for improved device performance. An impurity is implanted in the source/drain (S/D) regions after contact silicide formation and a spike anneal process is performed that lowers the schottky barrier height (SBH) of the interface between the silicide and the lower junction region of the S/D regions. This results in lower contact resistance and reduces the thickness (and Rs) of the region at the silicide-semiconductor interface.
US08470699B2 Method of manufacturing silicon carbide semiconductor apparatus
Disclosed is a method of manufacturing a silicon carbide semiconductor apparatus which provides a smooth silicon carbide surface while maintaining a high impurity activation ratio. The method of manufacturing a silicon carbide semiconductor apparatus which forms an impurity region in the surface layer of a silicon carbide substrate includes the steps of implanting an impurity into the surface layer of the silicon carbide substrate, forming a carbon film on the surface of the silicon carbide substrate, preliminarily heating the silicon carbide substrate with the carbon film as a protective film, and thermally activating the silicon carbide substrate with the carbon film as a protective film.
US08470690B2 Method for producing a multilayer film including at least one ultrathin layer of crystalline silicon, and devices obtained by means of said method
Method of fabricating a multilayer film having at least one ultrathin layer of crystalline silicon, the film being fabricated from a substrate having a crystalline structure and including a previously-cleaned surface. The method includes the steps of: a) exposing the cleaned surface to a radiofrequency plasma generated in a gaseous mixture of SiF4, hydrogen, and argon, so as to form an ultrathin layer of crystalline silicon having an interface sublayer in contact with the substrate and containing microcavities; b) depositing at least one layer of material on the ultrathin layer of crystalline silicon so as form a multilayer film, the multilayer film including at least one mechanically strong layer; and c) annealing the substrate covered in the multilayer film at a temperature higher than 400° C., thereby enabling the multilayer film to be separated from the substrate.
US08470689B2 Method for forming a multilayer structure
The method for forming a multilayer structure on a substrate comprises providing a stack successively comprising an electron hole blocking layer, a first layer made from N-doped semiconductor material having a dopant concentration greater than or equal to 1018 atoms/cm3 or P-doped semiconductor material, and a second layer made from semiconductor material of different nature. A lateral electric contact pad is made between the first layer and the substrate, and the material of the first layer is subjected to anodic treatment in an electrolyte.
US08470688B2 Semiconductor device and method for manufacturing the same
A semiconductor device and a method for manufacturing a semiconductor device are provided. A semiconductor device comprises a first single-crystal semiconductor layer including a first channel formation region and a first impurity region over a substrate having an insulating surface, a first gate insulating layer over the first single-crystal semiconductor layer, a gate electrode over the first gate insulating layer, a first interlayer insulating layer over the first gate insulating layer, a second gate insulating layer over the gate electrode and the first interlayer insulating layer, and a second single-crystal semiconductor layer including a second channel formation region and a second impurity region over the second gate insulating layer. The first channel formation region, the gate electrode, and the second channel formation region are overlapped with each other.
US08470686B2 Method of increasing deposition rate of silicon dioxide on a catalyst
Methods for forming dielectric layers, and structures and devices resulting from such methods, and systems that incorporate the devices are provided. The invention provides an aluminum oxide/silicon oxide laminate film formed by sequentially exposing a substrate to an organoaluminum catalyst to form a monolayer over the surface, remote plasmas of oxygen and nitrogen to convert the organoaluminum layer to a porous aluminum oxide layer, and a silanol precursor to form a thick layer of silicon dioxide over the porous oxide layer. The process provides an increased rate of deposition of the silicon dioxide, with each cycle producing a thick layer of silicon dioxide of about 120 Å over the layer of porous aluminum oxide.
US08470683B2 Method and electronic device for a simplified integration of high precision thinfilm resistors
The invention relates to a method of manufacturing an integrated circuit. An electrically resistive layer of a material for serving as a thin film resistor (TFR) is deposited. A first electrically insulating layer is deposited on the electrically resistive layer of the TFR. An electrically conductive layer of an electrically conductive material is deposited. An area is left without the conductive layer and the area overlaps the electrically resistive layer of the TFR. A second electrically insulating layer is deposited on top of the conductive layer. A first VIA opening is etched through the second insulating layer, the area without the conductive layer adjacent to the electrically conductive layer and through the first insulating layer down to the electrically resistive layer of the TFR. A conductive material is deposited in the first VIA opening so as to electrically connect the conductive layer and the electrically resistive layer of the TFR.
US08470681B2 Resistor with improved switchable resistance and non-volatile memory device
A resistor with improved switchable resistance includes a first electrode, a second electrode, and an insulating dielectric structure between the first and second electrodes. The insulating dielectric structure includes a confined conductive region providing a first resistance state and a second resistance state; the resistance state of the confined conductive region being switchable between the first and second resistance states by a control signal.
US08470680B2 Substrate with embedded patterned capacitance
A process for forming a laminate with capacitance and the laminate formed thereby. The process includes the steps of providing a substrate and laminating a conductive foil on the substrate wherein the foil has a dielectric. A conductive layer is formed on the dielectric. The conductive foil is treated to electrically isolate a region of conductive foil containing the conductive layer from additional conductive foil. A cathodic conductive couple is made between the conductive layer and a cathode trace and an anodic conductive couple is made between the conductive foil and an anode trace.
US08470676B2 Programmable element, and memory device or logic circuit
A multi-terminal programmable element. The programmable element includes a source electrode and a drain electrode on a base. The programmable element includes reference voltage contact that is not in contact with the source or drain electrode. The base includes a transition-metal oxide with oxygen vacancies for drifting under an applied electric field. Further, materials of the source electrode and the base are selected such that an interface of a source and/or drain electrode material and the transition metal oxide base material forms an energy barrier for electron injection from the electrode into the base material. The energy barrier has a height that depends on an oxygen vacancy concentration of the base material. Four non-volatile states are programmable into the programmable element.
US08470674B2 Structure, method and system for complementary strain fill for integrated circuit chips
A structure, method and system for complementary strain fill for integrated circuit chips. The structure includes a first region of an integrated circuit having multiplicity of n-channel and p-channel field effect transistors (FETs); a first stressed layer over n-channel field effect transistors (NFETs) of the first region, the first stressed layer of a first stress type; a second stressed layer over p-channel field effect transistors (PFETs) of the first region, the second stressed layer of a second stress type, the second stress type opposite from the first stress type; and a second region of the integrated circuit, the second region not containing FETs, the second region containing first sub-regions of the first stressed layer and second sub-regions of the second stressed layer.
US08470672B2 Method of manufacturing silicon carbide semiconductor device
A method of manufacturing a semiconductor device includes forming a drift layer on a substrate; forming a base layer on the drift layer; forming a trench to penetrate the base layer and to reach the drift layer; rounding off a part of a shoulder corner and a part of a bottom corner of the trench; covering an inner wall of the trench with an organic film; implanting an impurity to a surface portion of the base layer; forming a source region by activating the implanted impurity; and removing the organic film after the source region is formed, in which the substrate, the drift layer, the base layer and the source region are made of silicon carbide, and the implanting and the activating of the impurity are performed under a condition that the trench is covered with the organic film.
US08470671B1 Method of manufacturing a 3-D vertical memory
A novel method for manufacturing a 3-D vertical memory comprising the steps of dividing a multilayer structure composed of insulating intermediate layers and sacrificial intermediate layers into a first multilayer structure and a second multilayer structure, replacing the sacrificial intermediate layers in the multilayer structures with metal intermediate layers, and manufacturing the channel structure in two multilayer structures.
US08470670B2 Method for making semiconductor device
One or more embodiments may relate to a method for making a semiconductor device, including: a method for making a semiconductor device, comprising: providing a substrate; forming a charge storage layer over the substrate; forming a control gate layer over the charge storage layer; forming a mask over the control gate layer; using the mask, etching the control gate layer and the charge storage layer; forming a select gate layer over the etched control gate layer and the etched charge storage layer; forming an additional layer over the select gate layer; etching the additional layer to form sidewall spacers over the select gate layer; and etching the select gate layer.
US08470667B2 Semiconductor device including reservoir capacitor and method of manufacturing the same
A method of manufacturing a semiconductor memory device includes forming a first capacitor using a metal oxide semiconductor (MOS) transistor, forming a second capacitor being a pillar type corresponding to a cell capacitor formed in a cell region, and forming a third capacitor over the first and the second capacitors.
US08470664B2 Methods of fabricating a dual polysilicon gate and methods of fabricating a semiconductor device using the same
A dual polysilicon gate is fabricated by, inter alia, forming a polysilicon layer doped with impurities of a first conductivity type on a substrate having a first region and a second region, forming a mask pattern that covers the polysilicon layer in the first region and leaves the polysilicon layer in the second region, injecting impurities of a second conductivity type into the polysilicon layer in the second region left exposed by the mask pattern. Removing the mask pattern, and patterning the polysilicon layer to form a first polysilicon pattern in the first region and a second polysilicon pattern in the second region. The second polysilicon pattern is formed to have protrusions that laterally protrude from sidewalls thereof. Subsequently, impurities of the second conductivity type are injected into the substrate in the second region and into the protrusions of the second polysilicon pattern.
US08470663B2 Methods of manufacturing a semiconductor device
Methods of manufacturing a semiconductor device include forming integrated structures of polysilicon patterns and hard mask patterns on a substrate divided into at least an NMOS forming region and a PMOS forming region. A first preliminary insulating interlayer is formed on the integrated structures. A first polishing of the first preliminary insulating interlayer is performed until at least one upper surface of the hard mask patterns is exposed, to form a second preliminary insulating interlayer. The second preliminary insulating interlayer is etched until the upper surfaces of the hard mask patterns are exposed, to form a third preliminary insulating interlayer. A second polishing of the hard mask patterns and the third preliminary insulating interlayer is performed until the polysilicon patterns are exposed to form an insulating interlayer. The polysilicon patterns are removed to form an opening. A metal material is deposed to form a gate electrode pattern in the opening.
US08470661B2 High-K gate electrode structure formed after transistor fabrication by using a spacer
During a replacement gate approach, the inverse tapering of the opening obtained after removal of the polysilicon material may be reduced by depositing a spacer layer and forming corresponding spacer elements on inner sidewalls of the opening. Consequently, the metal-containing gate electrode material and the high-k dielectric material may be deposited with enhanced reliability.
US08470659B2 Method for reducing interfacial layer thickness for high-k and metal gate stack
This description relates to a method including forming an interfacial layer over a semiconductor substrate. The method further includes etching back the interfacial layer. The method further includes performing an ultraviolet (UV) curing process on the interfacial layer. The UV curing process includes supplying a gas flow rate ranging from 10 standard cubic centimeters per minute (sccm) to 5 standard liters per minute (slm), wherein the gas comprises inert gas, and heating the interfacial layer at a temperature less than or equal to 700° C. The method further includes depositing a high-k dielectric material over the interfacial layer.
US08470650B2 Semiconductor device and manufacturing method for the same
An object is to provide a method for manufacturing a highly reliable semiconductor device including thin film transistors which have stable electric characteristics and are formed using an oxide semiconductor. A method for manufacturing a semiconductor device includes the steps of: forming an oxide semiconductor film over a gate electrode with a gate insulating film interposed between the oxide semiconductor film and the gate electrode, over an insulating surface; forming a first conductive film including at least one of titanium, molybdenum, and tungsten, over the oxide semiconductor film; forming a second conductive film including a metal having lower electronegativity than hydrogen, over the first conductive film; forming a source electrode and a drain electrode by etching of the first conductive film and the second conductive film; and forming an insulating film in contact with the oxide semiconductor film, over the oxide semiconductor film, the source electrode, and the drain electrode.
US08470649B2 Semiconductor device
An object is to provide a highly reliable transistor and a semiconductor device including the transistor. A semiconductor device including a gate electrode; a gate insulating film over the gate electrode; an oxide semiconductor film over the gate insulating film; and a source electrode and a drain electrode over the oxide semiconductor film, in which activation energy of the oxide semiconductor film obtained from temperature dependence of a current (on-state current) flowing between the source electrode and the drain electrode when a voltage greater than or equal to a threshold voltage is applied to the gate electrode is greater than or equal to 0 meV and less than or equal to 25 meV, is provided.
US08470648B2 Method for manufacturing semiconductor device
A semiconductor device including a plurality of field-effect transistors which are stacked with a planarization layer interposed therebetween over a substrate having an insulating surface, in which semiconductor layers in the plurality of field-effect transistors are separated from semiconductor substrates, and the semiconductor layers are bonded to an insulating layer formed over the substrate having an insulating surface or an insulating layer formed over the planarization layer.
US08470647B2 Semiconductor device and manufacturing method thereof
There has been a problem that the manufacturing process is complicated and the number of processes is increased when a TFT with an LDD structure or a TFT with a GOLD structure is formed. In a method of manufacturing a semiconductor device, after low concentration impurity regions (24, 25) are formed in a second doping process, a width of the low concentration impurity region which is overlapped with the third electrode (18c) and a width of the low concentration impurity region which is not overlapped with the third electrode can be freely controlled by a fourth etching process. Thus, in a region overlapped with the third electrode, a relaxation of electric field concentration is achieved and then a hot carrier injection can be prevented. And, in the region which is not overlapped with the third electrode, the off-current value can be suppressed.
US08470646B2 Modulation of resistivity in carbon-based read-writeable materials
In a first aspect, a method of forming a memory cell is provided that includes (1) forming a metal-insulator-metal (“MIM”) stack above a substrate, the MIM stack including a carbon-based switching material having a resistivity of at least 1×104 ohm-cm; and (2) forming a steering element coupled to the MIM stack. Numerous other aspects are provided.
US08470643B2 Manufacturing method of semiconductor packages
Conductive core balls are joined to joint pads formed on an upper substrate. Core balls are joined to joint pads formed on an extending part of an upper-substrate substrate material. The joint pads formed on the extending part of the upper-substrate substrate material are joined to the joint pads formed on an extending part of a lower-substrate substrate material via the core balls. The joint pads formed in an area corresponding to the upper substrate of the upper-substrate substrate material are connected to the joint pads formed in an area corresponding to a lower substrate of the lower-substrate substrate material via the core balls and the conductive core balls. The upper-substrate substrate material is fixed to the lower-substrate substrate material by a mold resin supplied therebetween. The extending parts of the upper-substrate substrate material and the lower-substrate substrate material are removed, and the semiconductor packages are individualized.
US08470642B2 High density chip packages, methods of forming, and systems including same
Methods and devices for multi-chip stacks are shown. A method is shown that assembles multiple chips into stacks by stacking wafers prior to dicing into individual chips. Methods shown provide removal of defective chips and their replacement during the assembly process to improve manufacturing yield.
US08470640B2 Method of fabricating stacked semiconductor package with localized cavities for wire bonding
A method of fabricating a semiconductor die and a low profile semiconductor package are disclosed. The semiconductor package may include at least first and second stacked semiconductor die mounted to a substrate. The first and/or second semiconductor die may be fabricated with localized cavities through a bottom surface of the semiconductor die, along a side edge of the semiconductor die. The one or more localized cavities in a side take up less than the entire side. Thus, the localized cavities allow low height stacking of semiconductor die while providing each die with a high degree of structural integrity to prevent cracking or breaking of the die edge during fabrication.
US08470638B2 Thin film transistor array panel and manufacturing method thereof
A thin film transistor and a manufacturing method thereof are provided. In the manufacturing method of the thin film transistor a semiconductive active layer and a semiconductor passivation layer are sequentially formed such that the semiconductor passivation layer protectively covers the semiconductive active layer. Then the stacked combination of the semiconductive active layer and semiconductor passivation layer are patterned by using a same patterning mask so that formed islands of the semiconductive active layer continue to be protectively covered by formed islands of the semiconductor passivation layer. In one embodiment, the semiconductive active layer is formed of a semiconductive oxide.
US08470636B2 Aqueous process for producing crystalline copper chalcogenide nanoparticles, the nanoparticles so-produced, and inks and coated substrates incorporating the nanoparticles
The present invention relates to aqueous processes to make metal chalcogenide nanoparticles that are useful precursors to copper zinc tin sulfide/selenide and copper tin sulfide/selenide. In addition, this invention provides processes for preparing crystalline particles from the metal chalcogenide nanoparticles, as well as processes for preparing inks from both the metal chalcogenide nanoparticles and the crystalline particles.
US08470629B2 Method for manufacturing micromachine
A structure which prevents thinning and disconnection of a wiring is provided, in a micromachine (MEMS structure body) formed with a surface micromachining technology. A wiring (upper auxiliary wiring) over a sacrificial layer is electrically connected to a different wiring (upper connection wiring) over the sacrificial layer, so that thinning, disconnection, and the like of the wiring formed over the sacrificial layer at a step portion generated due to the thickness of the sacrificial layer can be prevented. The wiring over the sacrificial layer is formed of the same conductive film as an upper driving electrode which is a movable electrode and is thus thin. However, the different wiring is formed over a structural layer, which is formed by a CVD method and has a rounded step, and has a thickness of 200 nm to 1 μm, whereby thinning, disconnection, and the like of the wiring can be further prevented.
US08470627B2 Method for manufacturing semiconductor light emitting device
A method for manufacturing a semiconductor light emitting device is provided. The device includes: an n-type semiconductor layer; a p-type semiconductor layer; and a light emitting unit provided between the n-type semiconductor layer and the p-type semiconductor layer. The method includes: forming a buffer layer made of a crystalline AlxGa1-xN (0.8≦x≦1) on a first substrate made of c-plane sapphire and forming a GaN layer on the buffer layer; stacking the n-type semiconductor layer, the light emitting unit, and the p-type semiconductor layer on the GaN layer; and separating the first substrate by irradiating the GaN layer with a laser having a wavelength shorter than a bandgap wavelength of GaN from the first substrate side through the first substrate and the buffer layer.
US08470625B2 Method of fabricating semiconductor light emitting device and semiconductor light emitting device
A method of fabricating semiconductor light emitting device forms a laminated film by laminating an n-type nitride semiconductor layer, an active layer and a p-type nitride semiconductor layer in order on a uneven main surface of a first substrate, forms a plurality of first electrodes, on an upper surface of the p-type nitride semiconductor layer, forms a first metal layer to cover surfaces of the plurality of first electrodes and the p-type nitride semiconductor layer, forms a second metal layer on an upper surface of the second substrate, joins the first and second metal layers by facing the first and second substrates, cuts the first substrate or forming a groove on the first substrate along a border of the light emitting element from a surface side opposite to the first metal layer on the first substrate, and irradiates a laser toward areas of the light emitting devices from a surface side opposite to the first metal layer on the first substrate to peel off the first substrate.
US08470616B2 Patterned assembly for manufacturing a solar cell and a method thereof
Apparatuses and methods for manufacturing a solar cell are disclosed. In a particular embodiment, the solar cell may be manufactured by disposing a solar cell in a chamber having a particle source; disposing a patterned assembly comprising an aperture and an assembly segment between the particle source and the solar cell; and selectively implanting first type dopants traveling through the aperture into a first region of the solar cell while minimizing introduction of the first type dopants into a region outside of the first region.
US08470615B2 Thin layer solar cell module and method for producing it
The invention concerns a process for producing a thin layer solar cell module with a plurality of segments that are electrically connected in series and arranged on a common substrate. The invention additionally concerns the corresponding thin layer solar cell modules and a production line that is suitable for conducting the production process. The process has steps for application of layers onto the substrate to form at least one electrode and one photoactive layer sequence and has steps for structuring the applied and/or to be applied layers to form the plurality of segments. At least one electrode and one photoactive layer sequence are applied before structuring steps are carried out.
US08470612B2 Integrated circuits with magnetic core inductors and methods of fabrications thereof
In one embodiment, a method of forming a semiconductor device includes forming a first inductor coil within and/or over a substrate. The first inductor coil is formed adjacent a top side of the substrate. First trenches are formed within the substrate adjacent the first inductor coil. The first trenches are filled at least partially with a magnetic fill material. At least a first portion of the substrate underlying the first inductor coil is thinned. A backside magnetic layer is formed under the first portion of the substrate. The backside magnetic layer and the magnetic fill material form at least a part of a magnetic core region of the first inductor coil.
US08470610B2 Retentate chromatography and protein chip arrays with applications in biology and medicine
Analytes in a sample are resolved by retentate chromatography in a procedure involving adsorbing the analytes on a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
US08470609B2 Versatile drug testing device
A versatile drug testing device (a lateral flow diagnostic testing device) includes a flat transparent carrier with a top and a bottom with the carrier having a series of independent parallel grooves formed therein running from adjacent to the top to adjacent to the bottom of the carrier, each groove having a first opening and a second opening above the first opening therein adjacent to the bottom of the carrier, at least one drug test strip installed in one of said grooves with its absorbent pad contiguous to the openings and a cover layer attached to the carrier operable to sealing close each of said grooves whereby the bottom of the device can be immersed in a specimen of “urine”, “body fluid” or “other biological specimen” to wet the pad of the at least one test strip though the ingress of the specimen though the associated openings and the test results on the test strip can be easily viewed through the transparent carrier. Because of the unique construction the device will give accurate reading if temporarily immersed in the specimen or left in the specimen for an extended period of time, making it very user friendly.
US08470607B2 Inhibition of angiogenesis
The present invention is directed to novel methods of inhibiting angiogenesis using chlorotoxin agents. In some embodiments, the inventive methods include intravenous, intraocular, intravitreal, subjunctival injection, and/or topical administration of a chlorotoxin agent that may or may not be labeled. In some embodiments, the inventive methods allow treatment and/or amelioration of ocular diseases characterized by neovascularization, such as wet macular degeneration. In some embodiments, neovascularization is inhibited and/or newly formed vessels are caused to regress.
US08470606B2 Manipulation of beads in droplets and methods for splitting droplets
The invention provides a method of circulating magnetically responsive beads within a droplet in a droplet actuator. The invention also provides methods for splitting droplets. The invention, in one embodiment, makes use of a droplet actuator with top and bottom substrates, a plurality of magnetic fields respectively present proximate the top and bottom substrates, wherein at least one of the magnet fields is selectively alterable, and a plurality of droplet operations electrodes positioned along at least one of the top and bottom surfaces. A droplet is positioned between the top and bottom surfaces and at least one of the magnetic fields is selectively altered.
US08470603B2 Methods of evaluating diethylamide in glatiramer acetate
The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture.
US08470600B2 Biocompatible materials for mammalian stem cell growth and differentiation
A biocompatible material, wherein at least a part of a surface of the biocompatible material is characterized by a micro or nano-meter scale topographical structure comprising a plurality of features where the structure is selected to promote the growth of undifferentiated pluripotent stem cells or serve to promote the uniform differentiated growth of stem cells. Furthermore, a biocompatible material is provided having a surface structure and composition that affects a cellular function, in particular cellular functions related to gene induction, cell differentiation and the formation of bone tissue in vivo and ex-vivo.
US08470595B2 Mesenchymal stem cell and method for production thereof
The present invention provides a method for producing a mesenchymal stem cell having an ability to differentiate into a myoblast by culturing a pluripotent stem cell derived from a human or animal, including: i) preparing the pluripotent stem cell that has been cryopreserved, ii) sub-culturing the prepared pluripotent stem cell in an undifferentiated state for a prescribed number of times, iii) culturing the subcultured pluripotent stem cell under conditions that enable induction of differentiation into an adipocyte in vitro, and iv) separating and collecting a CD105-positive cell during the culturing process.
US08470582B2 Methods and organisms for the growth-coupled production of 1,4-butanediol
The invention provides a non-naturally occurring microorganism comprising one or more gene disruptions, the one or more gene disruptions occurring in genes encoding an enzyme obligatory to coupling 1,4-butanediol production to growth of the microorganism when the gene disruption reduces an activity of the enzyme, whereby the one or more gene disruptions confers stable growth-coupled production of 1,4-butanediol onto the non-naturally occurring microorganism. The microorganism can further comprise a gene encoding an enzyme in a 1,4-butanediol (BDO) biosynthetic pathway. The invention additionally relates to methods of using microorganisms to produce BDO.
US08470577B2 Viral vectors and their use in therapeutic methods
The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
US08470575B2 Mutant proteinase with reduced self-cleavage activity and method of purification
The present invention provides a mutant 27 kDa NIa proteinase having reduced self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant has the same substrate cleavage activity as the wild-type proteinase but is more stable than the wild-type proteinase. The present invention also provides a method of obtaining large quantities of active 27 kDa NIa proteinase for use as a tool for purification of other proteins.
US08470566B2 Microorganisms and methods for conversion of syngas and other carbon sources to useful products
A non-naturally occurring microbial organism having an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway includes at least one exogenous nucleic acid encoding an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway enzyme expressed in a sufficient amount to produce isopropanol, 4-hydroxybutryate, or 1,4-butanediol. The aforementioned organisms are cultured to produce isopropanol, 4-hydroxybutryate, or 1,4-butanediol.
US08470565B2 Use of ionic liquids for implementing a process for the preparation of biodiesel
The use of a combination of—at least one ionic liquid which is lipophilic, and non miscible with water, and—at least one enzyme, for the implementation of an esterification and/or transesterification process of a substrate with at least one alcohol, the substrate consisting of oils, fats, fatty acids, or a mixture thereof, wherein the ionic liquid, the substrate, and the alcohol form a single homogeneous liquid phase at the temperature at which the esterification and/or transesterification process is performed.
US08470563B2 Use of whole blood in PCR reactions
A method of obtaining DNA amplification of a nucleic acid target from a volume of whole blood comprising performing DNA amplification in a PCR assay mixture with a blood-resistant polymerase.
US08470561B2 GPCR comprising an IC2 insertion
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a family C G-protein coupled receptor (GPCR), wherein the first portion comprises the TM1, TM2 and TM3, regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, wherein the second portion comprises the TM4, TM5 TM6 and TM7 regions of the GPCR.
US08470559B2 Growth hormone fusion proteins
We disclose growth hormone [GH] fusion proteins that have increased in vivo stability and activity; nucleic acid molecules encoding said proteins and methods of treatment of growth hormone deficiency that use said fusion proteins. The GH fusion proteins comprise human GH covalently linked to the extracellular domain of Growth Hormone Receptor [GHR] either as a direct in-frame translational fusion or via a flexible peptide linker. The GH/GHR fusion proteins have exceptional pharmacokinetics and are potent growth hormone receptor agonists. The GH/GHR fusion proteins form head to tail dimers.
US08470557B2 Isolated nucleic acids encoding activated factor V and methods for production thereof
Methods for the treatment of coagulation disorders using Factor V/Va variants are provided.
US08470552B2 Strategy to reduce lactic acid production and control PH in animal cell culture
The present disclosure provides a method for culturing cells in exogenous lactic acid. Certain aspects of the present disclosure include the production of recombinant proteins, such as antibodies and fragments thereof. Certain aspects of the present disclosure also relate to methods of controlling lactic acid production, pH stability and osmolality in cell culture.
US08470551B2 Surface expression vector for fusion protein of Myo-2 peptide multimer and myostatin, and microorganism transformed by thereof
The present invention relates to a fusion protein in which a myostatin mature protein is fused to a multimer of myostatin-derived antigenic peptide Myo-2, a surface expression vector containing a polynucleotide encoding the fusion protein, a recombinant microorganism transformed with the vector, and a feedstuff additive or a pharmaceutical composition containing the microorganism as an effective ingredient. The feedstuff additive or pharmaceutical composition according to the present invention can be used for muscle development and regulation of muscle growth in livestock and poultry, as well as for preventing and treating muscle-wasting diseases and degenerative diseases such as muscular dystrophy, muscular atrophy and the like. In addition, the transformed strain shows the same effect even if the strain itself after culture thereof is directly used, and thus it is very economical.
US08470548B2 Diagnosis of depression
The present invention relates to the use of p11 as a drug target as well as a tool for the diagnosis, treatment and development of p11/5-HT receptor related disorders. The invention further relates to p11 knock-out animals as well as p11 transgenic animals and their use as models for the development of novel psychotherapeutic agents, and to methods of diagnosis, prophylaxis and treatment of p11/5-HT receptor related disorders.
US08470547B2 Biomarkers associated with nephropathy
Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof.
US08470545B2 Methods of modulating cold sensory perception via a cold- and menthol-sensitive receptor (CMR1)
The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
US08470543B2 Methods for differentiating and monitoring parathyroid and bone status related diseases
The present invention relates to novel methods and devices for differentiating in a patient parathyroid diseases, such as hyperparathyroidism and related bone diseases, from normal or non-disease states. One detects whole or non-fragmented (1 to 84) parathyroid hormone in a biological sample and also a large non-whole parathyroid hormone peptide fragment that can function as a parathyroid hormone antagonist. By either comparing values or using independently the value of either the large non-whole parathyroid hormone peptide fragment, the whole parathyroid hormone, or the combination of these values, one is able to differentiate parathyroid and bone related disease states, as well as differentiate such states from normal states.
US08470541B1 Methods for separation and immuno-detection of biomolecules, and apparatus related thereto
Disclosed are methods and apparatus for separation of biomolecules via two-dimensional gel electrophoresis, methods and apparatus for immunoblotting separated biomolecules, and methods for the use of biomolecules processed via the methods and apparatus of the present invention, including use in a clinical setting. The methods and apparatus for separation of biomolecules via two-dimensional gel comprises vertical agarose gel electrophoresis in the first dimension, and the electrophoresis of a novel non-denaturing 3-35% concave gradient polyacrylamide gel in the second dimension. This novel gel can be cast in a modified gel caster that can facilitate the pouring of multiple gels simultaneously. The methods and apparatus for immunblotting are useful with any type of immunoblotting, including Western blot, Northern blot, and Southern blot analyses. These methods and apparatus provide safe, efficient and cost-effective immunoblots, while facilitating the reduction of exposure to toxic or radioactive materials, as well as the disposal of those materials.
US08470535B2 Two stage nucleic acid amplification using an amplification oligomer
This invention provides methods, compositions and systems to detect a nucleic acid of interest in a two-stage amplification. The two-stage amplification begins with a first non-enzymatic accumulation of an amplification oligomer that is the target substrate for a second nucleic acid amplification or assay. Two or more amplification oligomers can be used to allow multiplexed amplifications of two or more nucleic acids of interest with deconvolution based on unique detection signals or unique signal locations.
US08470527B2 Method of inhibiting HIV-1 replication by administering modified GP41 C34 peptide derivatives with enhanced pharmacological properties
The claimed invention is directed toward modified HIV-1 gp41 C-terminal heptad repeat fusion inhibitors. In particular, peptide derivatives of C-34 were prepared (e.g., FB006M) and modified with 3-maleimidoproionic acid (MPA), which allows rapid and irreversible conjugation to serum albumin at a 1:1 molar ratio. These polypeptides have an extended half-life in vivo and display potent antiviral activity against HIV-1.
US08470525B2 Method for analyzing air
A method and device are disclosed for continuously detecting, classifying and identifying toxic particles, aerosols and/or vapor in an air sample, in near real time by directing an air sample containing an optional target analyte, in the form of particles, aerosols and/or vapors, enzyme(s), and enzyme substrate(s), to a surface of a collection matrix for forming a biocatalytic reaction product of a plurality of freely mobile optical reporters, and by using a light source with optical reader to interpret the signal from the optical reporter, enabling the detection, classification and identification of toxic particles, aerosols and/or vapor in the air sample.
US08470519B2 Method for removing photoresist pattern
Disclosed is a method of removing a photoresist pattern, which includes radiating light onto a substrate having a photoresist pattern formed thereon and implanted with a predetermined dopant so that the temperature of the substrate is increased to be equal to or higher than a temperature able to remove the photoresist pattern, and by which the photoresist pattern formed on the substrate can be almost completely removed using a simple process for radiating light onto the substrate so that the temperature of the substrate is increased to be equal to or higher than a temperature able to the photoresist pattern.
US08470516B2 Method of forming a relief pattern by e-beam lithography using chemical amplification, and derived articles
A method of generating a relief pattern comprises disposing a resist composition on a substrate to form a film, the resist composition comprising a first silsesquioxane polymer of the formula (1): a second silsesquioxane polymer of the formula (2): and a photosensitive acid generator; patternwise exposing the film by e-beam lithography; heating the exposed film to effect crosslinking of the first polymer and second polymer in the exposed area; and developing the exposed film to form a negative relief pattern.
US08470514B2 Information recording medium and method for manufacturing the same
A low-cost information recording medium is provided by which good recording quality can be obtained even when information is recorded thereon in a high density using a blue laser. The recording medium has a recording layer which comprises Sb, O and M. A content of O atoms is 30 atom % or more but not more than 55 atom %, a content of M atoms is 5 atom % or more but not more than 35 atom %, and a content of Sb atoms is 20 atom % or more but not more than 55 atom %. The recording layer does not contain Au, Pt and Pd.
US08470513B2 Radiation-sensitive resin composition and polymer
A radiation-sensitive resin composition includes a polymer that includes at least one repeating unit (i) selected from a repeating unit shown by a formula (1), (2), and (3); and a repeating unit (ii) shown by a formula (4). R1 represents a hydrogen atom or a methyl group. Each R2 independently represents one of a linear or branched alkyl group having 1 to 12 carbon atoms, a linear or branched alkoxy group having 1 to 12 carbon atoms, and an alicyclic hydrocarbon group having 3 to 25 carbon atoms. p is an integer from 0 to 3, and q is an integer from 1 to 3, and p+q≦5. A chemically-amplified positive-tone resist film that is sensitive to extreme ultraviolet rays (EUV) can be formed using the radiation-sensitive resin composition.
US08470509B2 Negative resist composition and patterning process
There is disclosed a negative resist composition wherein a base resin contains at least repeating units represented by the following general formula (1) and general formula (2) and has a weight average molecular weight of 1,000 to 10,000, and the compound containing a nitrogen atom as a basic component contains one or more kinds of amine compounds having a carboxyl group and not having a hydrogen atom covalently bonded to a base-center nitrogen atom. There can be a negative resist composition in which a bridge hardly occurs, substrate dependence is low and a pattern with a high sensitivity and a high resolution can be formed, and a patterning process using the same.
US08470503B2 Photosensitive resin composition for color filter and color filter using same
The present invention relates to a photosensitive resin composition for color filter of liquid-crystal displays, and particularly provides a photosensitive resin composition for reducing aggregation of pigment, which has superior development properties, and forms images having no undercut after development in the formation of green pixels for color filter. The composition comprises an alkali-soluble resin (A), a photopolymerizable monomer (B), a photoinitiator (C), an organic solvent (D), and a pigment (E). In which the pigment (E) comprises a halogenated phthalocyanine compound (E-1) as depicted in the undermentioned Formula (1): wherein, M is Al, Si, Sc, Ti, V, Fe, Co, Ni, Zn, Ga, Ge, Y, Zr, Nb, In, Sn or Pb; X1˜X16 are hydrogen atoms or halogen atoms, and the halogen atoms are fluorine atoms, chlorine atoms, bromine atoms or iodine atoms. The total number of halogen atoms is an integer between 8˜16; Y are fluorine atoms, chlorine atoms, bromine atoms, iodine atoms, oxygen atoms or hydroxyl groups; and m is an integer between 0˜2. The photoinitiator (C) comprises O-acyloxime photoinitiator (C-1) and triazine photoinitiator (C-2), and the proportion by weight of the photoinitiator (C-1) and the photoinitiator (C-2) is 20/80˜80/20.
US08470494B2 Membrane electrode assembly for fuel cell, method for making the same, and fuel cell system including the same
A membrane-electrode assembly for a fuel cell including a first substrate and a second substrate and a catalyst layer between the first substrate and the second substrate is provided, where the first substrate is a polymer electrolyte membrane and the second substrate is a electrode substrate, or the first substrate is the electrode substrate and the second substrate is the polymer electrolyte membrane. The catalyst layer has a h1/t1 ratio of about 0.5 or more, where s1 represents a point on the first substrate at one end of the catalyst layer, h1 represents a distance between the first substrate and the second substrate, s2 represents a point on the first substrate closest to s1 at which a height (h) of the catalyst layer becomes h1, and t1 represents the distance between the s1 and the s2. The membrane-electrode assembly can include a greater amount of catalyst by decreasing a shadow effect, and thereby increasing its energy density.
US08470490B2 Fuel cell stack
A fuel cell stack in which, even if the fuel cell stack is mounted in an inclined position, the performance of system components mounted on an end plate is maintained satisfactory. The fuel cell stack has a cell stack body formed by stacking a plurality of fuel battery single cells, and a pair of end plates for holding the cell stack body from respective sides in the stack direction. System components are mounted on one end plate. One end plate has a stack-facing surface facing the cell stack body and also has a system component mounting surface on the opposite side of the stack-facing surface. The system component mounting surface is inclined relative to the facing surface by an inclination angle so that, when the fuel cell stack is placed such that manifolds decline toward the one end plate, the system component mounting surface is vertical.
US08470489B2 Method for producing bipolar plates
Disclosed herein is a method of producing bipolar plates. In one embodiment, is method for producing bipolar plates, the method comprising (a) providing an electrically conductive sheet; and (b) cutting through the sheet to create therein at least one opening for a fluid, where the cut sheet includes a plurality of elongate parallel oxidant flow openings and where at least one oxidant inlet manifold opening and at least one oxidant outlet manifold opening are located at the ends of the elongate oxidant flow openings and in communication therewith.
US08470486B2 Fuel cell system
A fuel cell system has a plurality of fuel cells stacked in one or more groups of fuel cells. Each fuel cell includes a fuel electrode supplied with fuel gas at a fuel gas supply pressure, an oxidizing electrode supplied with oxidizing gas at an oxidizing gas supply pressure, and an electrolyte membrane disposed between the fuel electrode and the oxidizing electrode. A pressure-difference control unit generates a pressure difference across the membrane such that the fuel gas supply pressure is greater than the oxidizing gas supply pressure in each fuel cell, a cell-voltage measuring device measures a cell voltage for each fuel cell or each group of fuel cells in the fuel cell stack, and a leakage determination unit determines the presence or absence of a leaking cell based on the behavior of the cell voltage of each fuel cell while the pressure difference is increased with time.
US08470484B2 Fuel cell system
A fuel cell system capable of stably supplying hot water to a load is provided.The fuel cell system includes a solid-oxide fuel cell 31, a heat exchanger 40 that exchanges heat between an exhaust gas from the solid-oxide fuel cell 31 and water, a hot water storage tank 42 that reserves the water, circulation pipes 43a and 43b for circulating the water between the hot water storage tank 42 and the heat exchanger 40, and a circulation pump 41 provided to the circulation pipes 43a and 43b. The fuel cell system is provided with a controller 39 that controls the fuel utilization ratio during power generation by the solid-oxide fuel cell 31 in accordance with the used amount of reserved hot water.
US08470483B2 Wettable gas diffusion layer for a wet seal in a fuel cell
An example fuel cell stack (10, 40) includes a cathode plate (60) having oxidant flow passages (62) and coolant flow passages (64), and a porous anode plate (42) adjacent the coolant flow passages (64). The porous anode plate (42) includes fuel flow passages (46) and a network of pores (44) that fluidly connect the fuel flow passages (46) and the coolant flow passages (64). A membrane electrode arrangement (50) adjacent the fuel flow passages (46) generates electricity in a fuel cell reaction. A hydrophilic gas diffusion layer (48) between the membrane electrode arrangement (50) and the porous anode plate (42) distributes water from the coolant flow passages (64) to maintain or establish a wet seal (70) within the network of pores (44) that limits fuel transport through the network of pores (44) from the fuel flow passages (46) to the coolant flow passages (64).
US08470481B2 Power supply unit
A clean power supply unit with a high fuel utilization rate using a fuel cell is provided. The power supply unit of the present invention comprises a fuel cell using methanol as fuel; a secondary battery for supplying power to a load; a fuel cell control part for controlling the amount of fuel and/or air supplied to the above-mentioned fuel cell; and a power converter for converting the power output from the above-mentioned fuel cell to a predetermined voltage or current, supplying power to the load and/or the above-mentioned secondary battery and controlling the supplied power so as to fall within a predetermined range including the value at which the amount of methanol discharged from the above-mentioned fuel cell becomes minimized.
US08470480B2 Circulation of gas-entrained fuel cell coolant
Coolant velocity greater than zero everywhere within the coolant channels (78, 85) of fuel cells (38) in a fuel cell stack (37) is assured by providing a flow of gas in the coolant channels, the flow being created by gas pressure from a source (92) of pressurized gas, an oxidant reactant air pump (52), a source (75) of hydrogen-containing fuel, or the fuel outlet (47), or the outflow of a condenser (59). Positive pressure may be applied to the coolant inlet (66) or negative pressure from an eductor (97) may be applied to a gas outlet (90) of the coolant channels, or both. Using gas to induce flow within the coolant channels eliminates the need for a bubble-clearing liquid pump and reduces liquid inventory and other plumbing; this makes the fuel cell power plant more freeze tolerant. Biphase flow from the condenser, which may be a vehicle radiator (120), renders the coolant return flow more freeze tolerant. Separate cooler plates (122) may be used with a coolant management system (125).
US08470475B2 Non-aqueous electrolyte secondary battery
A non-aqueous electrolyte secondary battery includes: a positive electrode capable of absorbing and desorbing lithium; a negative electrode capable of absorbing and desorbing lithium; a separator interposed between the positive electrode and the negative electrode; and a non-aqueous electrolyte. The positive electrode includes a composite oxide represented by formula (1): LiNixM1-x-yLyO2 as an active material. The formula (1) satisfies 0.3≦x≦0.9 and 0≦y≦0.1. The element M is at least one selected from the group consisting of Co and Mn, and the element L is at least one selected from the group consisting of Mg, Al, Ti, Sr, Zn, B, Ca, Cr, Si, Ga, Sn, P, V, Sb, Nb, Ta, Mo, W, Zr, Y and Fe. The non-aqueous electrolyte includes a main solvent, a solute and vinyl ethylene carbonate.
US08470474B2 Nonaqueous electrolyte secondary battery and battery module
A nonaqueous electrolyte secondary battery, having an internal resistance of 10 mΩ or less as an alternating-current impedance value of 1 kHz, comprises a metal outer container, a nonaqueous electrolyte contained in the container, a positive electrode contained in the container, a negative electrode contained in the container, a separator interposed between the negative electrode and the positive electrode, a negative electrode lead having one end connected to the negative electrode, and a negative electrode terminal attached to the outer container so as to be connected electrically to the other end of the negative electrode lead, at least the surface of the negative electrode terminal which is connected to the negative electrode lead being formed of aluminum alloy with an aluminum purity of less than 99 wt. % containing at least one metal selected from the group consisting of Mg, Cr, Mn, Cu, Si, Fe and Ni.
US08470472B2 Non-aqueous electrolyte secondary battery, and method for fabricating non-aqueous electrolyte secondary battery
A non-aqueous electrolyte secondary battery includes a positive electrode containing a positive-electrode active material, a negative electrode containing a negative-electrode active material, and a non-aqueous electrolyte, and is characterized in that the non-aqueous electrolyte contains 1.0 wt % or less of a compound represented by formula (1) and 2.0 wt % or less of a cyclic sulfate ester represented by formula (2), based on the total weight of the non-aqueous electrolyte. By using the non-aqueous electrolyte including a specified amount of the compound represented by formula (1) and a specified amount of the cyclic sulfate ester, when the battery is used at a low temperature after being stored at a high temperature, the increase of the internal resistance is inhibited.
US08470471B2 Electrochemical cell having quasi-bipolar structure
Provided is an electrochemical cell having a quasi-bipolar structure, particularly, a case of the electrochemical cell in which an electrode assembly is accommodated. A reliable electrolyte isolation barrier wall is disposed between the case and the electrode assembly, and an electric connection part constructed using the case is provided for the electrochemical cell for voltage equalization.
US08470468B2 Lithium-ion batteries with coated separators
A porous polymer sheet or membrane is provided with a thin coating of an electrically non-conductive ceramic composition and the coating conforms to all surfaces, including the pore surfaces, of the membrane. Such a coated membrane serves well, for example, as an intra-cell separator in a lithium ion battery. The coating increases the mechanical properties and thermal stability of the separator in battery operation and retains electrolyte. The coating may be formed by a two-step vapor-phase process in which atoms of one or more metals such as aluminum, calcium, magnesium, titanium, silicon and/or zirconium are deposited in a conformal layer on a workpiece surface. The metal atoms may then be reacted with ammonia, carbon dioxide, and or water to form their respective non-conductive nitrides, carbides, and/or oxides on the surface. The two-step process is repeated as necessary to obtain a ceramic material coating of desired thickness.
US08470467B2 Battery connection topology
A battery module comprising a plurality of battery cells arranged in a stacked configuration, each of the battery cells including a first terminal disposed on a first end of the battery cell and a second terminal disposed on a second end of the battery cell, wherein the first terminal of at least one of the battery cells is in direct electrical communication with the second terminal of another non-adjacent one of the battery cells.
US08470465B2 Battery device, electronic apparatus, and battery system
Disclosed is a battery device including a battery enclosure incorporating a battery cell. The battery device further includes an output terminal that outputs power of the battery cell. The battery enclosure includes a first surface, a second surface, a first step surface, a second step surface, a first engaging portion, a second engaging portion, a first groove, and a second groove formed in the second step surface and the second engaging portion, and a recess is provided in at least one of the first step surface and the second step surface.
US08470461B2 Light weight gypsum board
The invention generally provides gypsum-containing slurries including stucco, naphthalenesulfonate dispersant, and pregelatinized starch. The naphthalenesulfonate dispersant is present in an amount of about 0.1%-3.0% by weight based on the weight of dry stucco. The pregelatinized starch is present in an amount of at least about 0.5% by weight up to about 10% by weight of pregelatinized starch by weight based on the weight of dry stucco in the formulation. Other slurry additives can include trimetaphosphate salts, accelerators, binders, paper fiber, glass fiber, and other known ingredients. The invention also comprises the gypsum-containing products made with such slurries, for example, gypsum wallboard, and a method of making gypsum wallboard.
US08470459B2 Nanocomposite dielectric coatings
The present invention describes processes for coating substrates with a nanocomposite SiCON material. In addition, the present invention describes the dielectric nanocomposite coatings.
US08470458B1 Erosion barrier for thermal barrier coatings
A workpiece, such as a turbine engine component, comprises a substrate, a thermal barrier coating on the substrate, and a hard erosion barrier deposited over the thermal barrier coating. The erosion barrier preferably has a Vickers hardness in the range of from 1300 to 2750 kg/mm2. The erosion barrier may be formed from aluminum oxide, silicon carbide, silicon nitride, or molybdenum disilicide. The erosion barrier may be formed using either an electrophoretic deposition process or a slurry process.
US08470457B2 Composite article having a solid solution protective layer
A composite article includes a substrate and a protective layer disposed on the substrate. The protective layer has a silicon-aluminum-carbon-nitrogen solid solution composition and microstructure.
US08470455B2 Organic electroluminescent device
An organic EL device 100 including a plurality of emitting layers (15) and (17) between a cathode (18) and (19) and an anode (12), each of the emitting layers (15) and (17) made of a host material having a triplet energy gap of 2.52 eV or more and 3.7 eV or less, and a dopant having a light emitting property related to a triplet state, the dopant containing a metal complex with a heavy metal.
US08470451B2 Projection blackboard
A projection blackboard having both of an excellent blackboard function and an excellent screen function, and a process for producing the same. The surface enamel layer that is an outermost layer of the enamel layers is formed by using a enameling upper glaze wherein at least titanium oxide coated particles, or a titanium oxide glaze together therewith is blended into a. transparent mat glaze, so as to render the layer an enamel layer having a predetermined color tone, a surface characteristic that the Rz is from 5 to 25 μm and a reflective characteristic that the peak gain is 0.28 or more, or having these properties and a glossiness Gs(75°)of 1 to 30%. This makes it possible to produce a blackboard excellent in both of blackboard function and screen function. The titanium oxide coated particles are preferably particles wherein surfaces of mica particles are coated with titanium oxide.
US08470450B2 Method of producing two-layered copper-clad laminate, and two-layered copper-clad laminate
Provided is a method of producing a two-layered copper-clad laminate with improved folding endurance, wherein the two-layered copper-clad laminate retains folding endurance of 150 times or more measured with a folding endurance test based on JIS C6471 by subjecting the laminate in which a copper layer is formed on a polyimide film through sputtering and plate processing to heat treatment at a temperature of 100° C. or more but not exceeding 175° C. Specifically, provided are a method of producing a two-layered copper-clad laminate (two-layered CCL material) in which a copper layer is formed on a polyimide film through sputtering and plate processing, wherein the rupture of the outer lead part of a circuit can be prevented due to the improvement in folding endurance; and a two-layered copper-clad laminate obtained from the foregoing method.
US08470448B2 Acryl resin containing film, polarizing plate by use thereof and liquid crystal display
An acryl resin-containing film which is transparent and highly heat-resistant and has been significantly improved in brittleness is disclosed, satisfying the following equations (1) to (4), exhibiting a tension softening point of 105 to 145° C. and a photoelastic coefficient of −5.0×10−8 to 8.0×10−8 cm2/N, while causing no ductile fracture. There is also disclosed a liquid crystal display which has achieved an improved yield in works of stamping a polarizing plate or sticking the plate to a panel and reduced color shift occurred depending on viewing angle. |Ro(589)|≦10 nm  Equation (1) |Rth(589)|≦20 nm  Equation (2) |Ro(480)−Ro(630)|≦5 nm  Equation (3) |Rth(480)−Rth(630)|≦10 nm  Equation (4) Numerical values of 589, 480 and 630 in parentheses represent the wavelength (nm) of a light used to measure an individual birefringence.
US08470446B2 Silane acrylate containing intermediate transfer members
A UV curable intermediate transfer media, such as a belt, that includes a first supporting substrate, such as a polyimide substrate layer, and a second surface layer of a mixture of a carbon nanotube component, a photoinitiator component, and an organic inorganic hybrid component.
US08470445B2 Resin laminate, method for production thereof, and transfer film for use in the production of resin laminate
Disclosed is a resin laminate having a surface layer excellent in antistatic properties, scratch resistance, and transparency. Also disclosed is a method for producing the resin laminate with a high productivity. Further disclosed is a transfer film for use in the production of the resin laminate. The resin laminate comprises a resin shaped article, an antistatic layer containing a π-electron conjugated conductive polymer and at least one resin selected from a polyester resin, a polyurethane resin, a polyesterurethane resin, an acrylic resin, and a melamine resin on at least one surface of the shaped article, and a cured coating film layer obtained by curing a curable resin on the antistatic layer. The method for producing the resin laminate preferably comprises the steps of forming the cured coating film layer and the antistatic layer on a mold using a transfer film, carrying out cast polymerization of a raw material for a resin, and detaching the resin laminate from the mold after the polymerization is completed.
US08470443B2 Hydrophobicization of silicas under oxidizing conditions
Modified silicas having low silanol content which are compatible with polar compositions are prepared by modifying silica with a difunctional reactive organosilane or polydialkylsiloxane under oxidizing conditions below 400° C. The silicas have a distinct proportion of T1, T2, and T3 groups.
US08470441B2 Cable wire prepared using distannoxane catalysts
A fabricated article (e.g., jacketed or insulated wire or cable) is prepared by a process comprising the steps of: applying a coating of a moisture-curable composition onto a wire or cable; and reacting the moisture-curable composition with water, wherein the moisture-curable composition comprises at least one resin having hydrolysable reactive silane groups and a tin catalyst characterized by the tin having a +4 oxidation state and a bis(alkoxide) ligand. The product of the process includes a wire or cable comprising a jacket, wherein the jacket comprises at least one poly olefin resin having hydrolysable reactive silane groups and a tin catalyst, the tin catalyst having a bis(alkoxide) ligand and characterized by the tin having a +4 oxidation state. The product of the process also includes a wire or cable comprising a jacket wherein the jacket comprises (i) the reaction product of at least one polyolefin resin having hydrolysable reactive silane groups and water, and (ii) at least one tin catalyst, the tin catalyst having a bis(alkoxide) ligand and characterized by the tin having a +4 oxidation state.
US08470440B2 Regenerative non-tacky adhesive fastening system for use in consumer products
A non-tacky adhesive fastening system may have a first configuration and a second configuration. The non-tacky adhesive fastening system comprises an engaging member and a receiving member. In the first configuration, the engaging member comprises a first non-tacky member and the receiving member comprises an intermediate non-tacky member and a second non-tacky member. The intermediate non-tacky member is refastenably joined to the second non-tacky member. In the second configuration, the non-tacky adhesive fastening system comprises the engaging member having the first non-tacky member and the intermediate non-tacky member and the receiving member comprises the second non-tacky member. The second configuration is formed upon fastening the engaging surface of the first non-tacky member to the primary surface of the intermediate non-tacky member and separating the engaging member from the receiving member.
US08470439B2 Durable antireflective film
Antireflective films are described having a surface layer comprising a the reaction product of a polymerizable low refractive index composition comprising at least one free-radically polymerizable fluoropolymer and surface modified inorganic nanoparticles. A high refractive index layer is coupled to the low refractive index layer. In one embodiment, the high refractive index layer comprises surface modified inorganic nanoparticles dispersed in a crosslinked organic material. The antireflective film is preferably durable, exhibiting a haze of less than 1.0% after 25 wipes with steel wool using a 3.2 cm mandrel and a mass of 1000 grams.
US08470428B2 Optical recording medium
An optical recording medium includes an inorganic recording layer, a first protective layer provided on at least one surface of the inorganic recording layer and containing indium oxide, and a second protective layer provided so as to be adjacent to the first protective layer and containing titanium oxide, zirconium oxide, or tin oxide.
US08470426B2 Read-only optical information recording medium and sputtering target for depositing reflective film for the optical information recording medium
Provided is a read-only optical information recording medium (for instance, a dual-layer BD-ROM), which uses blue laser and is provided with a reflecting film which has sufficiently high reflectivity while ensuring optical transparency required in manufacture, has excellent reproduction stability when used for an optical information recording medium and has excellent durability. The read-only optical information recording medium includes a structure wherein a plurality of laminated layers of the reflecting film and the optical transparent layer are formed on a substrate, and reproduces information by means of blue laser. The reflecting film closest to the substrate among the reflecting films is substantially composed of an Al-based alloy containing 0.5-3.0 atm % of Ti, and has a film thickness of 10 nm or more but not more than 30 nm.
US08470423B2 Plastics pipe
A plastics pipe having a stabilized inner layer, wherein the inner layer comprises an extruded thermoplastic polymer comprising at least one polar stabilizer, wherein: (i) the thermoplastic polymer is provided with pendant polar functional groups, and/or (ii) the thermoplastic polymer comprises an effective amount of at least one filler provided with pendant polar functional groups, and/or (iii) the thermoplastic polymer comprises a blend of a non-polar thermoplastic polymer and a thermoplastic polymer provided with pendant polar functional groups.
US08470418B2 Exhaust pipe for internal combustion engine, and internal combustion engine and transportation apparatus incorporating the same
An exhaust pipe for an internal combustion engine includes a metal tube enclosing a passage through which an exhaust gas from the internal combustion engine passes, and a ceramic film covering the metal tube from the outside, the ceramic film containing no more than about 0.5 mass % of a metallic element which is dominantly present in a surface of the metal tube. The ceramic film is an SiON film containing about 30 mass % or less of O and about 10 mass % or more of N.
US08470417B2 Packaging inserts with myoglobin blooming agents, packages and methods for packaging
Food packaging inserts comprising a myoglobin blooming agent that promote or preserve the desirable appearance of food products, food packages, and methods of food packing comprising the same, are provided.
US08470416B2 Transparent ink-jet recording films, compositions, and methods
Transparent ink-jet recording films, compositions, and methods are disclosed. Such films do not exhibit excessive ink drying times. These films can be free of such visual effects as mud cracking. These films are useful for medical imaging.
US08470413B2 Retardation compensators of negative C-type for liquid crystal display
Disclosed is a negative C-type retardation compensator for a liquid crystal display. The negative C-type retardation compensator for the liquid crystal display includes polyarylate having a thio group or a sulfur oxide group in a polymer main chain thereof. Accordingly, the retardation compensator has an absolute value of negative retardation that is larger in a thickness direction than a retardation compensator which includes polyarylate having no thio group or sulfur oxide group in a polymer main chain thereof even though the retardation compensator having the thio group or sulfur oxide group and the retardation compensator having no thio group or sulfur oxide group are the same as each other in thickness. Thereby, the negative C-type retardation compensator for liquid crystal displays is capable of being desirably applied to the liquid crystal displays.
US08470412B2 Liquid crystal alignment agent, liquid crystal alignment film manufactured using the same, and liquid crystal display device including the liquid crystal alignment film
Disclosed is a liquid crystal alignment agent that includes a polymer comprising polyamic acid including a repeating unit represented by the following Chemical Formula 1, polyimide including a repeating unit represented by the following Chemical Formula 2, or a combination thereof. In Chemical Formulae 1 and 2, X1, X2, Y1 and Y2 are the same in the detailed description.
US08470409B2 Nanowires, method of fabrication the same and uses thereof
A method of forming a nanowire structure is disclosed. The method comprises applying on a surface of carrier liquid a layer of a liquid composition which comprises a surfactant and a plurality of nanostructures each having a core and a shell, and heating at least one of the carrier liquid and the liquid composition to a temperature selected such that the nanostructures are segregated from the surfactant and assemble into a nanowire structure on the surface.
US08470397B2 Peelable composite thermoplastic sealants in packaging films
A peelable sealing structure includes a sealing layer and one or more optional additional layers. The peelable sealing structure includes a sealing surface that is formable into a peelable seal upon contact with a sealing substrate at all temperatures in a peelable seal temperature range. Moreover, the peelable sealing structure comprises a thermoplastic polymer and an additive dispersed within at least a portion of the thermoplastic polymer with the peelable sealing structure defining the sealing surface.
US08470391B2 Magnetic recording media
A method for manufacturing discrete track media and patterned media is disclosed which enables a magnetic recording layer having excellent magnetic characteristics to be obtained without imparting damage to a crystal orientation control layer which is at the surface when forming the magnetic recording layer. The method for manufacturing magnetic recording media comprises a process of forming a soft magnetic layer on a substrate; a process of forming a first crystal orientation control layer on the soft magnetic layer; a process of providing a depression in at least a portion of the first crystal orientation control layer; a process of performing heat treatment of the first crystal orientation control layer; and a process of forming a magnetic recording layer on the first crystal orientation control layer.
US08470390B2 Oxidation-free copper metallization process using in-situ baking
A method of forming an integrated circuit structure includes providing a substrate; forming a metal feature over the substrate; forming a dielectric layer over the metal feature; and forming an opening in the dielectric layer. At least a portion of the metal feature is exposed through the opening. An oxide layer is accordingly formed on an exposed portion of the metal feature. The method further includes, in a production tool having a vacuum environment, performing an oxide-removal process to remove the oxide layer. Between the step of forming the opening and the oxide-removal process, no additional oxide-removal process is performed to the metal feature outside the production tool. The method further includes, in the production tool, forming a diffusion barrier layer in the opening, and forming a seed layer on the diffusion barrier layer.
US08470388B1 Electroluminescent devices and their manufacture
A process for producing a conformal electroluminescent system. An electrically conductive base backplane film layer is applied upon a substrate. A dielectric film layer is applied upon the backplane film layer, then a phosphor film layer is applied upon the dielectric film layer. An electrode film layer is applied upon the phosphor film layer using a substantially transparent, electrically conductive material. An electrically conductive bus bar may be applied upon the electrode film layer. Preferably, the backplane film layer, dielectric film layer, phosphor film layer, electrode film layer and bus bar are aqueous-based and are applied by spray conformal coating. The electroluminescent phosphor is excitable by an electrical field established across the phosphor film layer such that the device emits electroluminescent light upon application of an electrical charge between the backplane film layer and at least one of the electrode film layer and the bus bar.
US08470382B2 Carnitine granulate and methods for its production
Subject of the invention is a method for the production of a carnitine granulate, which includes the steps of (a) providing an aqueous solution comprising at least 65% (w/w) carnitine, (b) providing a particulate carrier comprising silica, the carrier having an average particle size of more than 150 μm, and (c) mixing the aqueous solution and the carrier. Another subject of the invention is a carnitine granulate.
US08470379B2 Use of a potent product extracted from rhizomes of zingiber officinale in treating a disease associated with Helicobacter pylori
A new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a normal phase chromatography column, and eluting the column with a first eluent having a polarity lower than that of a mixture of n-hexane and ethyl acetate in a weight ratio of 6:4 to obtain a potent fraction. Preferably, the potent fraction is substantially free of both 6-gingerol and 6-shogaol.
US08470378B2 Anti-influenza viral composition containing bark or stem extract of Alnus japonica
The present invention relates to an antiviral composition comprising an Alnus japonica extract, more specifically, relates to a method for preparing high activated anti-influenza viral composition, which comprises an extract of the bark or stem of Alnus japonica, and an anti-influenza viral composition comprising the extract. An extract of the bark or stem of Alnus japonica according to the present invention has low toxicity to normal cells, while having an excellent antiviral effect even when administered at low concentration and thus the composition comprising the Alnus japonica extract can be used effectively in preventing and treating influenza viral infection.
US08470366B2 Nicotine containing soft gelatin pastilles
The present invention relates to soft pastilles for nicotine replacement therapy, said pastille comprises about 0.05% to about 1% of nicotine active; about 5% to about 40% of gelling agent; about 30% to about 70% of plasticizer; about 0.05% to about 10% of sweetener; 0.5% to about 30% of releasing agent; about 0.05% to about 2% of preservative; about 0.01% to 5% of flavoring agent; and about 5% to about 20% of water.
US08470364B2 Once daily formulations of tetracyclines
Disclosed are once-daily formulations containing tetracyclines, especially doxycycline. Such formulations are useful, for instance, for the treatment of collagenase destructive enzyme-dependent diseases, such as periodontal disease and acne, and acute and chronic inflammatory disease states, such as rosacea and arthritis.
US08470362B2 Methods for sealing a vascular puncture using a plug including unreactive precursors
Methods for sealing a puncture communicating with a blood vessel are provided that include introducing a porous carrier formed from lyophilized hydrogel or other material into the puncture. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture.
US08470361B2 Non-abusable pharmaceutical composition comprising opioids
There is provided pharmaceutical compositions for the treatment of pain comprising a pharmacologically-effective amount of an opioid analgesic, or a pharmaceutically-acceptable salt thereof, presented in particulate form upon the surfaces of carrier particles comprising a pharmacologically-effective amount of an opioid antagonist, or a pharmaceutically-acceptable salt thereof, which carrier particles are larger in size than the particles of the opioid analgesic. The compositions are also useful in prevention of opioid abuse by addicts.
US08470360B2 Drug depots having different release profiles for reducing, preventing or treating pain and inflammation
Effective treatments of pain and/or inflammation are provided. Through the administration of an effective amount of at least analgesic and/or at least one anti-inflammatory agent at or near a target site, one can reduce, prevent or treat inflammation and pain.
US08470357B2 Methods of treatment with Syk inhibitors
The present invention provides novel compositions and methods for inhibiting restenosis, thrombosis, and/or inflammation in a patient undergoing a vascular intervention. More particularly, the present invention provides intravascular devices coated with one or more spleen tyrosine kinase (Syk) inhibitors. Methods for inhibiting restenosis, thrombosis, and/or inflammation in a patient by treatment with such intravascular devices are also provided. In addition, the present invention provides methods for treating sickle cell disease using Syk inhibitors.
US08470348B2 Skin cleansing agent, particularly for removing printing inks and/or soiling caused by ink
The invention relates to a skin cleansing agent, particularly for the removal of printing colors and/or inks, comprising the components a) 1 to 70 wt.-% of at least one ethoxylated amine and/or ethoxylated diamine, b) 30 to 70 wt.-% of at least one polyethylene glycol of general formula H—O—(CH2CH2—O)nH, wherein n is an integer of from 1 to 150, c) 1 to 30 wt.-% of at least one fatty alcohol polyglycol ether, d) 0.1 to 5 wt.-% of at least one complexing agent, e) 0 to 30 wt.-% of at least one reducing or oxidizing agent, f) 0 to 25 wt.-% of one or more abrasives, g) 0 to 10 wt.-% of at least one polyhydric alcohol, h) 0 to 3 wt.-% water, i) optionally one or more viscosity-building agents, j) optionally further cosmetic adjuvants, additives and/or active substances, the sum of components a) through j) making 100 wt.-%, relative to the composition of the cleansing agent.
US08470341B2 Escherichia coli immunogens with improved solubility
Variants of the pathogenic E. coli ‘AcfD precursor’ have been identified with increased solubility as compared to the native AcfD protein that raise a substantially similar immune response in a subject as the native AcfD protein.
US08470340B2 Peptides presenting an epitope of a domain of factor H binding protein and methods of use
Polypeptides that can elicit antibodies that are bactericidal for different fHbp variant strains of N. meningitidis, and methods of use, are provided.
US08470337B2 Therapeutic treatments using botulinum neurotoxin
Methods for treating a coronary risk factor (such as hypertension, diabetes, hyperlipidemia and obesity) and/or a respiratory disorder (such as asthma, chronic obstructive pulmonary disease and bronchitis) and/or arthritis by local administration of a botulinum neurotoxin to at least one of a head, neck or shoulder location (for example, by subdermal, subcutaneous or intramuscular administration of the botulinum neurotoxin) of a patient with a coronary risk factor, respiratory disorder or arthritis.
US08470332B2 Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR
The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins in pharmaceutical preparations and derivatives of such proteins and the uses of same in diagnostic, research and therapeutic applications. The invention further provides cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins.
US08470330B2 PSMA antibodies and uses thereof
The invention includes stable multimeric, particularly dimeric, forms of PSMA protein, compositions and kits containing dimeric PSMA protein as well as methods of producing, purifying and using these compositions. Such methods include methods for eliciting or enhancing an immune response to cells expressing PSMA, including methods of producing antibodies to dimeric PSMA, as well as methods of treating cancer, such as prostate cancer.
US08470329B2 Combination therapy with antibody-drug conjugates
Methods for the treatment of Hodgkin's lymphoma comprising administering both a chemotherapeutic regimen and an antibody-drug conjugate compound to a subject in need thereof are provided.
US08470323B2 Drug delivery to human tissues by single chain variable region antibody fragments cloned by phage display
The present invention relates to the use of non-pathogenic antibodies to deliver biologically-active proteins to specific cellular and sub-cellular sites. The invention also relates to the use of non-pathogenic antibodies to deliver biologically-active, non-protein molecules to specific cellular and sub-cellular sites.
US08470321B2 Antibodies specific for the protofibril form of beta-amyloid protein
Isolated antibodies have been characterized which show specific affinity to a repeating conformational epitope of a protofibril form of the human β-amyloid peptide as compare to low molecular weight forms of β-amyloid peptide. These isolated antibodies and related pharmaceutically effective compositions may be useful in the therapeutic and/or prophylactic treatment of Alzheimer's disease by effectively blocking the ability of the protofibril form of β-amyloid peptide to form fibril forms linked with complications associated with Alzheimer's disease. The isolated antibodies of the present invention are also useful in various diagnostic assays and associated kits.
US08470318B2 Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods
The invention provides a polypeptide containing at least one IgG Fc region, wherein said at least one IgG Fc region is glycosylated with at least one galactose moiety connected to a respective terminal sialic acid moiety by a α 2, 6 linkage, and wherein said polypeptide having a higher anti-inflammatory activity as compared to an unpurified antibody.
US08470315B2 Non-natural ribonuclease conjugates as cytotoxic agents
The present invention is directed toward the delivery of a toxic protein to pathogenic cells, particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that has been modified to make it toxic to target cells and that can be conjugated to a target cell-specific delivery vector, such as an antibody, for delivery to pathogenic cells.
US08470312B2 Abrogating proinflammatory cytokine production during oncolytic reovirus therapy
Provided herein are methods for treating a proliferative disorder in a subject comprising administering to the subject one or more reoviruses and one or more agents that modulate expression or activity of pro-inflammatory cytokines. For example, the agents may inhibit expression or activity of pro-inflammatory cytokines.
US08470309B2 Enhanced medical implant comprising disrupted tooth pulp and tooth particles
A medical implant comprising in components from a tooth and stem cells harvested from at least one tooth. Tooth stem cells may be harvested from the dental pulp of mammalian teeth, such as unerupted third molars in humans. After the stem cells are removed and isolated from the other teeth tissue, the hard tooth may be ground into a base material for the manufacture of a porous matrix into which the tooth stem cells can be added. Additionally, soft tissue from the harvested tooth may be used as a carrier scaffold for soft tissue applications such as meniscal or cartilage repair.
US08470306B2 Crosslinked polysiloxanes, a process for their preparation and use of the crosslinked polysiloxanes in emulsifier systems for water-in-oil emulsions
The invention relates to crosslinked organopolysiloxanes which are linked by a polyether building block via the Si atoms, to emulsifier systems which have these crosslinked organopolysiloxanes, and also to cosmetic, dermatological or pharmaceutical formulations comprising a crosslinked organopolysiloxane or an emulsifier system comprising these.
US08470305B2 Shampoo containing a gel network
A shampoo composition comprising: a) from about 5% to about 50% of one or more detersive surfactants, by weight of said shampoo composition; b) a dispersed solid crystalline gel network phase comprising: i) a first component comprising at least about 0.05% of one or more fatty acids by weight of said shampoo composition; ii) a second component comprising at least about 0.05% of one or more additional fatty amphiphiles by weight of said shampoo composition; iii) water; and c) at least about 20% of an aqueous carrier, by weight of said shampoo composition; wherein said first component is combined with said second component in the ratio of 10:1 to about 1:5 to form said solid crystalline gel network phase.
US08470303B2 Automated method and system for introducing molecular iodine into drinking water
A system and method for delivering molecular iodine or any other substance into a pet's drinking water on a daily basis without exceeding the safe amount allowed for the pet. The present invention delivers a particular amount of molecular iodine into the pet water supply to achieve maximum benefit of I2 to reduce or eliminate bad pet breath and minimize total iodine in the pet diet so that 20-40 μg/mL/Kg/day iodine is consumed for optimum thyroid health. The preferred method is to use a solution created by dissolving iodine crystals in absolute ethanol. The iodine will only be in solution as I2 for a short time as it undergoes out gassing and hydrolysis at neutral pH. The present invention removes the iodine from the drinking water after the pet drinks. Therefore, during the day, pets will get no additional iodine—only fresh water from the water reservoir. Each enrolled pet is recognized by the system using an ID tag such as an RFID tag. This insures that, when there are multiple enrolled pets, each pet receives its specific dose, and only as often as is programmed. Vitamins, drugs and other substances can also be administered to pets using the present invention.
US08470296B2 Intracorporeal medicaments for high energy phototherapeutic treatment of disease
New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation. In embodiments of the present invention, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.
US08470291B2 Process to prepare a gas mixture of hydrogen and carbon monoxide
Process to prepare a gas mixture of hydrogen and carbon monoxide from an ash containing carbonaceous feedstock by performing the following steps, (i) partial oxidation of the ash containing carbonaceous feedstock with an oxygen containing gas thereby obtaining liquid ash and a gas mixture comprising hydrogen, carbon monoxide and solids, (ii) separating more than 90 wt % of the liquid ash from the gas mixture, (iii) reducing the temperature of the gas mixture, in the absence of the separated ash (iv) scrubbing the cooled gas of step (iii) by contacting with liquid water obtaining a scrubbed gas and a water effluent containing ash, (v) separating the ash from the water effluent by means of a decanter centrifuge thereby obtaining a wet ash and a stream of water poor in ash.
US08470288B2 Preparation of CZTS in an ionic liquid
The present invention relates to synthesis of copper zinc tin sulfide, Cu2ZnSnS4(CZTS) in an ionic liquid, using a mixture of copper-containing sulfides, zinc-containing sulfides, and tin-containing sulfides. Cu2ZnSnS4 is useful as an absorber material in thin film solar cells.
US08470283B2 Method for growing carbon nanotubes having a predetermined chirality
A method for growing carbon nanotubes having a determined chirality includes fragmenting at least one initial carbon nanotube having a determined chirality to obtain at least two portions of carbon nanotube. Each portion has a free growth end. Atoms of carbon are supplied with an autocatalyst addition of the atoms of carbon at the free growth end of each portion of nanotube to determine an elongation or growth of the nanotube.
US08470281B2 Method of producing carbonate using carbon dioxide microbubbles and carbonate thereof
Disclosed herein is a method of producing carbonate, comprising the steps of: providing a water-containing solution including cations that are precipitated in the form of a salt after undergoing a precipitation reaction with carbonate ions; and generating carbon dioxide microbubbles having a diameter of 50 μm or less in the water-containing solution to induce the precipitation reaction between the cations and the carbonate ions. The method is advantageous in that the carbonate produced using the microbubble system disclosed in the method can be practically used as high-priced building materials, filler for paper manufacturing, etc. and can also be used in foods, medicines and the like depending on the purity thereof, so that it can be recovered in a high yield. Further, the method is advantageous in that carbon dioxide is consumed, and cations can be effectively removed from waste water, so that it is environmentally useful.
US08470270B2 Method for extracting rare earth elements from phosphogypsum
The present invention relates to methods for recovering rare earth elements, in particular, from phosphogypsum.The claimed method comprises acidic extraction of rare earth elements from phosphogypsum using sulfuric acid-nitric acid mixture solution at 3.2-1.2 ratio with concentration of 1-3% by weight and at liquids-solids ratio of 4-5 within 8-12 minutes with simultaneous hydroacoustic action on the extraction suspension agent being mixed succeeded by separation of insoluble gypsum from extraction suspension agent and by recovery of rare earth elements from extraction solution using cation-exchange sorption by passing the latter through cation-exchange filter.The claimed method allows both to increase the recovery rate of rare earth elements and to reduce by half the time of the process accomplished at lower concentrations and with smaller volumes of acidic reagents.
US08470265B2 Anti-static pipette tip trays
Provided herein are anti-static pipette trays that reduce the amount of static charge accumulated on or in pipette tips and allow for discharge of any accumulated static charge.
US08470264B2 Analytic substrate coating method
An apparatus and method for producing a coated analytic substrate using a compact and portable automated instrument located in the laboratory setting at the point of use which can consistently produce one or a plurality of coated analytic substrates “on demand” for using the analytic substrate immediately after coating, preferably without a step of rinsing the coated analytic substrate before use. The apparatus preferably uses applicator cartridges having a reservoir containing the coating compositions used to form the coatings. Preferably the cartridges are removable and interchangeable to facilitate the production of individual analytic substrates having different coatings or different coating patterns. These coated analytic substrates have superior specimen adhesion characteristics due to the improved quality of the coatings applied by the coating apparatus and due to the quickness with which the coated analytic substrates can be used in the lab after production.
US08470260B2 Light beam guided liquid delivery device
A light beam guided liquid delivery device for tracking the placement of a sample by a liquid delivery device into a receptacle like a milliliter or microliter scale tube, or a microtiter plate, includes a liquid delivery device and a light beam generator. The light beam generator may be positioned on the outside or inside of the liquid delivery device. The light beam generator may be adapted to shoot a light beam below the tip of the liquid delivery device, whereby, a user may track the placement of the tip of the liquid delivery device via the light beam.
US08470258B2 Surface-structured device for life-science applications
Embodiments of the invention relate a surface-structured device for life-sciences and a life-science method applying the surface-structured device. The surface-structured device has a substrate with a frontside surface corresponding to a first surface; and a plurality of protrusions arranged on the frontside surface. A shortest dimension of the protrusions at the junction from the protrusion to the front-side surface is smaller than 250 nm and at least a first group of the plurality of protrusions is arranged on a first planar area of the frontside surface in a first regular pattern in a plane of the first planar area of the frontside surface. Further embodiments relate to a stamper which may be used in the manufacturing method of the surface-structured device and a manufacturing method for surface-structured device.
US08470255B2 Honeycomb filter and method for producing honeycomb filter
There is provided a honeycomb filter wherein particles having an average particle diameter smaller than the average pore diameter of partition walls are deposited at least in open pores formed in the surface layer of the partition wall and in the pores of the partition wall in a surface layer portion of the partition walls on the exhaust gas inflow side, thereby forming a composite region. The average pore diameter of the partition walls is 5 to 40 μm, and the porosity of the partition wall is 35 to 75%. The particles to be deposited have an average particle diameter of 1 to 15 μm, and the height of the composite region is not more than 80 μm in the direction from the outermost contour line of the partition walls to the surface of the partition walls.
US08470253B2 Exhaust flow distribution device
The present disclosure relates to an diesel exhaust treatment device including a main body having a central longitudinal axis that extends between first and second ends of the main body. A catalyzed substrate is positioned within an interior of the main body. A side inlet is positioned at a side of the main body for directing exhaust gas into the interior of the main body. A flow distribution element is positioned within the interior of the main body at a location between the side inlet and an upstream face of the substrate. The flow distribution element extends across a direction of exhaust flow through the main body and is mounted at a side of the main body that is opposite the side inlet.
US08470251B2 Apparatus for separating pitch from slurry hydrocracked vacuum gas oil
An apparatus is disclosed for converting heavy hydrocarbon feed into lighter hydrocarbon products. The heavy hydrocarbon feed is slurried with a particulate solid material to form a heavy hydrocarbon slurry and hydrocracked in a slurry hydrocracking unit to produce vacuum gas oil (VGO) and pitch. A first vacuum column separates VGO from pitch, and a second vacuum column further separates VGO from pitch. As much as 15 wt-% of VGO can be recovered by the second vacuum column and recycled to the slurry hydrocracking unit. A pitch composition is obtained which can be made into particles and transported without sticking together.
US08470250B2 Polyester production system employing horizontally elongated esterification vessel
A polyester production process employing an esterification system that utilizes a horizontally elongated esterification vessel as an esterification reactor and/or a vapor-liquid disengagement vessel.
US08470249B2 Apparatus for making gaseous clathrate
An apparatus for making a gaseous clathrate has a closed reaction vessel to which are fed a reaction gas and a reaction liquid while an interior of the vessel is maintained at a predetermined pressure and a predetermined temperature so that the gaseous clathrate is formed in the vessel. An outlet nozzle on the vessel defines a flow passage opening into the vessel and having an inner wall surface extending between an inner inlet end inside the vessel and an outer outlet end. The passage extends along an axis, is rotation-symmetrical about the axis, and is of decreasing flow cross section from its inner end to its outer end. The inner wall surface is curved in an S-shape from the inner end to the outer end so that pressure in the vessel forces the formed clathrate out through the passage with increasing compression as the flow cross section decreases.
US08470247B2 Surfaces resistant to non-specific protein adsorption and methods of producing the same
A method of preventing non-specific adsorption of proteins onto a surface can include providing a substrate that has a surface on which surface groups are attached. A solution can be applied to the surface that includes a protective reagent having a terminal functional group exhibiting a dipole moment. A monolayer comprising the protective reagent is assembled on the surface by reacting the protective reagent with the surface groups, thereby creating a protected surface. The protective reagent alone is sufficient to confer to the protected surface an increased resistance to adsorption of proteins.
US08470242B2 Apparatus having improved gantry assembly suitable for use in a laboratory environment
An assembly suitable for use in a laboratory instrument is set forth. The assembly comprises a plurality of guide rods that are disposed generally parallel with one another and a plurality of carriage assemblies connected for movement along the plurality of guide rods. A sub-carriage assembly is disposed on at least one of the carriage assemblies and is connected to the carriage assembly for movement in a direction transverse to the plurality of guide rods. A plurality of carriage drive mechanisms are employed to move the plurality of carriage assemblies independently along said plurality of guide rods and a sub-carriage drive mechanism is provided to move the sub-carriage assembly in a direction transverse to said plurality of guide rods.
US08470237B2 Stainless steel excellent in corrosion resistance, ferritic stainless steel excellent in resistance to crevice corrosion and formability, and ferritic stainless steel excellent in resistance to crevice corrosion
The stainless steel of the first embodiment includes C: 0.001 to 0.02%, N: 0.001 to 0.02%, Si: 0.01 to 0.5%, Mn: 0.05 to 0.5%, P: 0.04% or less, S: 0.01% or less, Ni: more than 3% to 5%, Cr: 11 to 26%, and either one or both of Ti: 0.01 to 0.5% and Nb: 0.02 to 0.6%, and contains as the remainder, Fe and unavoidable impurities. The stainless steel of the second embodiment has an alloy composition different from those of the first and third embodiments and satisfies the formula (A): Cr+3Mo+6Ni≧23 and formula (B): Al/Nb≧10 and contains as the remainder, Fe and unavoidable impurities. The stainless steel of the third embodiment has an alloy composition different from those of the first and second embodiments and includes either one or both of Sn: 0.005 to 2% and Sb: 0.005 to 1% and contains as the remainder, Fe and unavoidable impurities.
US08470234B2 Support architecture
A method of forming a component from solid freeform fabrication comprising the step of building an integral support around the component during manufacture thereof. The stiffness the support provides to the component is selected to minimize deformation of the component either during the manufacture of the component or during a subsequent heat treatment process.
US08470233B2 Metal mold for use in molding lens cover and method for producing lens cover
A metal mold for molding a lens cover can be provided without increasing the size of the metal mold or the production costs so as to prevent deterioration of production efficiency while also preventing any unfilled area or a thin thickness portion of a resin material from being formed in a final product. Also provided is a method for producing a lens cover utilizing such a metal mold. The metal mold can have a stationary mold, a movable mold and a slidable mold between them. A cavity for molding a lens sealing portion can be formed between the stationary mold and the movable mold, and the slidable mold can have a projection portion projecting into the cavity.
US08470227B2 Method for the production of a plastic product having a hard plastic component and a soft plastic component, and plastic product produced using said method
A plastic product having a hard plastic component and a soft plastic component that adheres to the hard plastic component via at least one boundary surface is produced as follows: initially the soft component is injection molded in an injection molding die. Then the hard component is injection molded. In the plastic product produced in this manner, the soft component is surrounded over at least part of the circumference thereof by the hard component in the circumferential direction about a main demolding direction of the injection molding die. The result is a plastic product, wherein the shape and arrangement of the soft component can be tailored to functional requirements more flexibly.
US08470220B2 Method and device for producing polyester granules and/or shaped parts with a low acetaldehyde content
In the case of the method for the production of polyester granulate or molded articles from a melt which is discharged from a polycondensation (1), the melt in the discharge region (2) of the polycondensation is kept at a temperature between 270-285° C. in communication with a gas chamber at a reduced pressure in order according to the invention to achieve a low acetaldehyde content. With respect to the granulate, within the scope of the method according to the invention, a standard crystallization (5) and drying (6) with air as drying gas suffices. The molded articles can be produced directly from the melt, e.g. with an injection molding machine (9). The device according to the invention comprises a polycondensation, at least the last stage of which is configured as a disc reactor in which, with extensive avoidance of a sump, the melt is transported directly from disc to disc by a combination of rotating disc and static strippers fitted on the circumference of the reactor. In the discharge region, the melt is conveyed directly into the discharge unit by static strippers without an accumulation of melt occurring here.
US08470218B2 Process and device for manufacturing a composite strand
The invention relates to a process and a device for manufacturing a composite strand formed by combining continuous glass filaments with continuous high-shrinkage organic thermoplastic filaments.
US08470215B2 Process for manufacturing breakable capsules useful in tobacco products
A method for manufacturing breakable capsules (50) that are useful for incorporating into a tobacco product (10), such as smoking articles and smokeless tobacco products, is provided. The method comprises forming a plurality of droplets comprising a core composition and a coating composition. The coating composition comprises a material that gelates in contact with a multivalent ion. The method also comprises introducing the plurality of droplets in a first aqueous solution having a first concentration of a first multivalent ion such that the coating composition of the plurality of droplets gelates to form a plurality of raw capsules. The method further comprises introducing the plurality of raw capsules in a second aqueous solution having a second concentration of a second multivalent ion, wherein the second concentration is higher than the first concentration, such that the coating composition of the plurality of raw capsules hardens to form a plurality of breakable capsules (50).
US08470211B2 Ferroelectric ceramic material with a low sintering temperature
The present invention provides new ferroelectric ceramic materials which can be sintered at a temperature lower than that of the conventional ferroelectric ceramic materials and upon sintering, devices formed of the new ferroelectric ceramic materials possesses excellent piezoelectric properties which are suitable for many industrial applications. The ferroelectric ceramic material includes a composition with a general formula of wPb(Ni1/3Nb2/3)O3-xPb(Zn1/3Nb2/3)O3-yPb(Mg1/3Nb2/3)O3-zPbZrO3-(1−w−x−y−z)PbTiO3, in which 0
US08470208B2 Organometallic complexes
The present disclosure relates to organometallic complexes and electronic devices containing the complexes. The complexes have the formula MYnZ, where n is 1, 2, or 3; M is a metal in a +2, +3, or +4 oxidation state, Y is selected from an 8-hydroxyquinolate and a substituted 8-hydroxyquinolate, and Z is a phenolate. At least one Y is a substituted 8-hydroxyquinolate having the formula where: R1 and R2 are the same or different at each occurrence and each represents one or more of a substituent selected from the group consisting of H, alkyl, fluoroalkyl, aryl, fluoroaryl, alkylaryl, alkoxy, aryloxy, fluoroalkoxy, fluoroaryloxy, heteroalkyl, fluoroheteroalkyl, heteroaryl, fluoroheteroaryl, heteroalkylaryl, heteroalkoxy, heteroaryloxy, fluoroheteroalkoxy, fluoroheteroaryloxy, a solvent-solubilizing group, and a Tg enhancing group, wherein at least one of R1 and R2 is a solvent-solubilizing or Tg enhancing group; and R3 is selected from the group consisting of H, an alkyl group, and a substituted alkyl group.
US08470207B2 Nano-positive electrode material of lithium cell and method for preparation thereof
The present invention relates to a nano-positive electrode material of lithium cell and preparation thereof. And the material comprising Lithium iron phosphate as substrate, conductive doping ion and voltage-boosting doping ion, have the general chemical formula: (Lix[M1-x])(Fey[N1-y])PO4, wherein: x=0.9˜0.96; y=0.93˜0.97; M represents conductive doping ion; N represents voltage-boosting doping ion. The material is prepared by solid phase reaction, of which the process for preparation includes: all raw materials is mixed homogeneously-milled into powder-pellet-formed-isothermally sintered for 2˜3 hours under 200˜400° C. in inner atmosphere-cooled-milled into powder-pellet-formed-isothermally sintered for 15˜20 hours under 500˜780° C. in inner atmosphere-cooled-milled into powder-airflow grinded and classified. The method is of low production cost, easy to operate, environment friendly and of high yield. The nano-positive electrode material of lithium cell prepared by the solid phase reaction, wherein the conductivity is higher than 10−2 S/cm, and the actual discharge capacity>250 mAh/g. And it can be fast charged/discharged in high power. It is provided with the characteristic of low production cost, easy operation method, safety and environment friendly. And it is applicable to small polymer, gel and liquid lithium cell, especially to power cell with high power.
US08470206B2 Method of producing anode material
There are provided a method of producing an anode material for a non-aqueous electrolyte secondary battery which is suitable for use in a high input/output current-type non-aqueous electrolyte secondary battery exemplified by a non-aqueous electrolyte secondary battery for a hybrid electric vehicle (HEV), has reduced irreversible capacity and superior charge-discharge efficiency, and an anode material obtained by the above production method.A method of producing an anode material for a non-aqueous electrolyte secondary battery from a petroleum-based pitch material, comprising a tar removal step in which an infusibilized pitch having an oxygen content of 5 to 20 wt % is heated to a temperature of 480° C. to 700° C. while flowing an inert gas at the space velocity of 0 to 120 (min−1).
US08470201B2 Al2O3-SiO2-based oxide phosphor
An oxide phosphor that is highly durable and produces visible light when excited by exposure to near-ultraviolet excitation light, comprising an oxide having the composition represented by the formula (Al2O3)x.(SiO2)1-x, where 0
US08470200B2 Production process of long-lasting phosphor
The present invention provides a production process for the production of an MAl2O4:Eu type long-lasting phosphor (M representing an alkaline earth metal). The process includes the steps of mixing a BAM (alkaline earth aluminate) phosphor with an alkaline earth compound and calcinating the resulting mixture.
US08470198B2 Mesogenic compounds comprising discotic and calamitic groups
The invention relates to novel calamitic mesogenic compounds which are especially suitable for use in birefringent films with negative optical dispersion, to novel liquid crystal (LC) formulations and polymer films comprising them, and to the use of the compounds, formulations and films in optical, electrooptical, electronic, semiconducting or luminescent components or devices.
US08470193B1 Magnetorheological fluids including shape memory alloys
Magnetorheological (MR) fluids are disclosed herein. An example of the MR fluid includes a carrier fluid, magnetic particles disposed in the carrier fluid, and non-magnetic particles disposed in the carrier fluid. The non-magnetic particles are particles of a shape memory alloy having an Austenite finish temperature (Af) that is lower than a temperature encountered in an application in which the MR fluid is used so that the shape memory alloy exhibits stress-induced superelasticity.
US08470192B2 Artificial snow and method for making same
A non-toxic, non-static, environmentally benign artificial snow product is made by extruding a mixture of starch, polyvinyl alcohol, hydrogenated soy flakes and talc to form an extruded starch product and processing the extruded starch product into snow flake like fragments. The snow flake like fragments may be sorted by size. Colorant may be added to yield artificial snow flakes in various festive colors.
US08470191B2 Topography reduction and control by selective accelerator removal
Plating accelerator is applied selectively to a substantially-unfilled wide (e.g., low-aspect-ratio feature cavity. Then, plating of metal is conducted to fill the wide feature cavity and to form an embossed structure in which the height of a wide-feature metal protrusion over the metal-filled wide-feature cavity is higher than the height of metal over field regions. Most of the overburden metal is removed using non-contact techniques, such as chemical wet etching. Metal above the wide feature cavity protects the metal-filled wide-feature interconnect against dishing, and improved planarization techniques avoid erosion of the metal interconnect and dielectric insulating layer. In some embodiments, plating of metal onto a substrate is conducted to fill narrow (e.g., high-aspect-ratio feature cavities) in the dielectric layer before selective application of plating accelerator and filling of the wide feature cavity.
US08470184B2 Method for making a cavity in the thickness of a substrate which may form a site for receiving a component
A method for making a micro-device including at least one receiving site for components, formed in a thickness of a substrate. The method includes: a) making in at least one first substrate adhesively bonded to a second substrate via a discontinuous adhesive bonding interface, at least one first trench around at least one sacrificial block of the first substrate, by etching the first substrate so as to expose the adhesive bonding interface; and b) removing the sacrificial block so as to make at least one first cavity in the first substrate.
US08470183B2 Systems and methods for extracting sand from raw slurry material
The present invention may be embodied as a processing system for processing raw slurry material. The processing system comprises a barrel member, at least one pre-processing member, and a plurality of separator members. The at least one pre-processing member and the plurality of separator members are supported by the barrel member, and the plurality of separator members define at least one separator gap. As the barrel member rotates about the processing axis A, the at least one pre-processing member transports at least a portion of the raw slurry material from the feed portion to the separator portion through the pre-processing portion. The plurality of separator members transport at least a portion of the raw slurry material from the pre-processing portion to the outlet opening through the separator portion.
US08470182B2 Apparatus and method for hydrolyzing biological material
Apparatus and method for hydrolyzing biological material for safe disposal thereof without the necessity of incineration or use of disinfectants are described. An alkaline solution having a concentration and an amount effective for hydrolyzing the biological material is brought into contact therewith by means of rotating paddles which both pound the biological material into small pieces and thoroughly mix the alkaline solution with the material under pressure and at elevated temperature. Following the hydrolysis of the biological material, a chosen portion of the water is removed from the alkaline solution and from the liquefied biological material, such that the resulting product solidifies when cooled. The present safe disposal of the biological material does not require incineration thereof, the addition of disinfectants thereto, or the discharge of liquid effluent containing processed biological material into the sewage system.
US08470179B2 Solar membrane distillation system and method of use
A water distillation system includes a membrane distillation unit which produces desalinated water from feed water comprising salt water. The system also includes a primary water heater which raises a temperature of the feed water upstream of the feed water entering the membrane distillation unit. The system additionally includes an evaporative cooler which lowers a temperature of a coolant upstream of the coolant entering the membrane distillation unit.
US08470176B2 Encapsulation of nano-materials for fluid purification/separation
Disclosed is an apparatus and method whereby small particle nano materials may be contained in a highly functional package for fluid separation and/or purification applications. The package consists of an aerogel material which uniformly surrounds the nano-particles. The aerogel may be composed of carbon, silicon, or silicon oxide or other suitable materials. The morphological features of the aerogel may be tailored specifically towards fine particle and ultrafine particle containment while maintaining uniform fluid flow in separation and purification processes. The aerogel may be bonded to a suitable rigid housing by chemical or mechanical means.
US08470175B2 Space reducing filter with supplemental fluid processing element
A fuel filter, such as a filter for filtering gasoline or diesel fuel to be supplied to an internal combustion engine, includes an annular main filter element through which fluid to be filtered can pass radially, and a supplemental fluid processing element disposed within the main filter element to which fluid discharged from the main filter element passes. The filter also has end caps, between which opposite ends of both the main filter element and the supplemental fluid processing element are disposed, and to which the opposite ends of both the main filter element and the supplemental fluid processing element are secured. Fluid is discharged from a central volume of the filter through one of the end caps.
US08470173B2 Column packing apparatus and method of making and using the same
Column packing apparatus are disclosed. Methods of making and using column packing apparatus are also disclosed.
US08470167B2 Device for dosed transfer of filtered softened water inside boilers of steam household appliances
A device for the dosed transfer of filtered softened water inside boilers of household appliances includes a tank, a cartridge including a water softening agent, a double drain pipe with vertical axis. The double drain pipe is formed of an adjacent pair of conduits and situated downstream a drain hole configured to be closed by a shut-off plate which is normally closed by the return action of a spring
US08470165B2 Process for the production of high-quality kerosene and diesel fuels for the coproduction of hydrogen from saturated light cuts
Process for the production of high-quality kerosene and diesel fuels and for the coproduction of hydrogen from a so-called light naphtha cut to which any quantity of LPG cut can be added where the steps of the process include: separating normal and iso-paraffins, dehydrogenation of the paraffins, oligomerization of the olefins and hydrogenation of the oligomerized olefins, the process permitting the production of kerosene and diesel fuels meeting market specifications, or even improved relative to the latter.
US08470157B2 Method and apparatus for ammonia (NH3) generation
Various apparatuses and methods for producing ammonia are provided. One embodiment has uses in a plurality of environments and an electrode configured to be exposed to the plurality of environments. The electrode is configured to receive hydrogen while being exposed to one of the environments, reduce nitrogen while being exposed to another environment, and allow the hydrogen and nitrogen to react with each other to form ammonia. Other embodiments provide for simultaneous hydrogen oxidation and nitrogen reduction at the same electrode, which in turn react for formation of ammonia.
US08470153B2 Cartridge and system for manipulating samples in liquid droplets
A cartridge (1) comprises a working film (10) for manipulating samples in liquid droplets with an electrode array (20) when the working film (10) of the cartridge (1) is placed on said electrode array (20). The cartridge (1) comprises a body (2,2′,2″) with a number of wells (5) configured to hold therein reagents (6) or samples (6′); a flexibly deformable top structure (7) impermeable to liquids and configured to seal a top side of the wells (5); a piercable bottom structure (8) impermeable to liquids and configured to seal a bottom side of the wells (5); a working film (10) located below a lower surface (4) of the body (2,2′,2″), the working film (10) being impermeable to liquids and comprising a hydrophobic upper surface (11); a peripheral spacer (9,9′,9″) located below the lower surface (4) of the body (2,2′,2″) and connecting the working film (10) to the body (2,2′,2″); a gap (12) between the lower surface (4) of the body (2,2′,2″) and the hydrophobic upper surface (11) of the working film (10), the gap (12) being defined by the peripheral spacer (9,9′,9″); and a number of piercing elements (13) located below piercable bottom structures (8) and configured to pierce the piercable bottom structures (8) for releasing reagents or samples (6,6′) from the wells (5) into the gap (12). Also disclosed is a system (40) with an electrode array (20) onto which the cartridge (1) can be placed.
US08470150B2 Method of fabricating electrode structures on substrate
Methods for fabricating electrode structures on a substrate are presented. The fabrication method includes providing a substrate with a patterned metal layer thereon, defining an electrode area. A passivation glue is formed on the patterned metal layer. An electrode layer is formed in the electrode area. A filling process is performed to deposit nano metal oxides on the electrode layer to extensively fill the entire electrode area.
US08470147B2 Co-fired gas sensor
A sensor for detecting a gas is provided. The gas sensor may have a sensing section, a heating section, and a resistance temperature detector. The resistance temperature detector may be co-fired to be integral with at least one of the sensing section and the heating section.
US08470144B2 Electrode device for an electrochemical sensor chip
An electrode device for an electrochemical sensor chip includes an insulation sheet having an insulating property and including a top surface and a bottom surface opposite to each other in a thickness direction, and electrode members having a conductivity and held by the insulation sheet in portions piercing the insulation sheet in a thickness direction, one ends of the electrode members located on the top surface side of the insulation sheet being connected to the analyte, other ends located on the bottom surface side of the insulation sheet being connected to the electrodes of the transducer, recesses for trapping the analyte being formed in the top surface of the insulation sheet so as to correspond to the electrode members, the one ends of the electrode members being exposed at a bottom of the recesses.
US08470141B1 High power cathode
A magnetron sputtering electrode for use within a magnetron sputtering device that includes a cathode body, a target receiving area defined adjacent the cathode body, a plurality of magnets received within a magnet receiving chamber and an anode shield surrounding the cathode body. At least a portion of a coolant passageway is defined by the anode shield, whereby the coolant passageway is adapted to receive coolant to circulate therethrough thereby cooling the anode shield.
US08470138B2 Odor mitigation in a recycler assembly
A distillation assembly that reduces malodors resulting from a process of recycling a solvent from a contaminated solvent solution that includes a distillation chamber defined by a top wall, a side wall and a bottom wall, a heating element disposed in the distillation chamber including an active portion and an inactive portion. The contaminated solvent solution disposed at a level within the distillation chamber such that the active portion always disposed below the level.
US08470133B2 Belt for a machine for the production of a fibrous web, particularly paper or cardboard, and method for the production of such a belt
A belt for a machine for the production of a fibrous web, in particular paper or cardboard, the belt including a carrier structure, a first material which forms a first pattern on at least one side of the carrier structure such that a portion of the carrier structure remaining exposed, and a second material which forms a second pattern, the second pattern being applied onto the first pattern, wherein the second pattern is completely disposed within the first pattern and a method for producing same.
US08470131B2 Apparatus and method to remove at least one chip-like semiconductor component from a film
Apparatus and a method for operating the apparatus to remove at least one chip-type semiconductor component from an adhesive film. The method comprises: arranging a lifting device with respect to the film, wherein a contact region of the lifting device bears against a second main surface of the film, opposite a chip-type semiconductor component that is arranged on a first main surface and is to be lifted off. Then, applying either a constant vacuum to a plurality of suction cutouts of the lifting device, by means of an assigned vacuum regulating device, or applying different values of the vacuum for different suction cutouts or groups of suction cutouts. Next, partially deforming the film in the contact region by using lifting means arranged in assigned cutouts of the lifting device to lift the film. Finally, using a removal device to remove the at least one semiconductor component from the film.
US08470129B1 Method and machine for separating liquid crystal panel and liner pad
The present invention provides a method and machine for separating a liquid crystal panel and a liner pad. The method includes (1) providing a separation machine and a combination of the liquid crystal panel and liner pad to be separated, the separation machine including a separation device that includes a suction device, air blasting devices and shaking devices; (2) the suction device moving toward the combination; (3) a central suction nozzle first engaging and sucking a liner pad of the combination and later the first suction nozzles engaging the sucking the liner pad of the combination; (4) the shaking devices being operated to subject the combination to vibration and the air blasting devices being operated to eject air streams to side edges of the combination; and (5) the combination, after being subjected to vibration and air streams, being separated so as to realize separation of the liquid crystal panel and liner pad.
US08470127B2 Cam-locked showerhead electrode and assembly
A showerhead electrode and assembly useful for plasma etching includes cam locks which provide improved thermal contact between the showerhead electrode and a backing plate. The cam locks include cam shafts in the backing plate which engage enlarged heads of studs mounted on the showerhead electrode. The assembly can include an annular shroud surrounding the showerhead electrode and eight of the cam shafts in the backing plate can be operated such that each cam shaft simultaneously engages a stud on the annular shroud and a stud in an outer row of studs on the showerhead electrode. Another eight cam shafts can be operated such that each cam shaft engages a pair of studs on inner and middle rows of the studs mounted of the showerhead electrode.
US08470126B2 Wiggling control for pseudo-hardmask
An apparatus for etching features in an etch layer is provided. A plasma processing chamber is provided, comprising a chamber wall, a chuck, a pressure regulator, an electrode or coil, a gas inlet, and a gas outlet. A gas source comprises a fluorine free deposition gas source and an etch gas source. A controller comprises at least one processor and computer readable media, comprising computer readable code for providing a conditioning for a patterned pseudo-hardmask, wherein the conditioning comprises computer readable code providing a fluorine free deposition gas comprising a hydrocarbon gas, computer readable code for forming a plasma, computer readable code for providing a bias less than 500 volts, and computer readable code for forming a deposition on top of the patterned pseudo-hardmask, computer readable code for etching the etch layer, and computer readable code for cyclically repeating the conditioning and etching at least twice.
US08470125B2 Multilayer retaining ring for chemical mechanical polishing
A carrier head for a chemical mechanical polishing apparatus includes a retaining ring having a flexible lower portion and a rigid upper portion.
US08470124B1 Cold pressing process for polyamide epichlorohydrin (PAE) based wood adhesive
Embodiments of the present disclosure describe ambient temperature pressing (“cold pressing”) of a wood-based product using protein/PAE adhesives within industrially suitable set times and press pressures. A method includes preparing an adhesive comprising a protein source and polyamideamine-epichlorohydrin (PAE) resin, applying the adhesive to one or more wood-based components, and cold pressing the one or more wood-based components to form a wood-based structure, the cold pressing being the only pressing operation in the formation of the wood-based structure after applying the adhesive to the one or more wood-based components. Other embodiments may be described and/or claimed.
US08470122B2 Method for the production of an abrasion-resistant film and finish film produced according to said method
A method for the production of an abrasion-resistant film (7, 9), in particular for the production of laminate floor materials or abrasion-resistant furniture surfaces, comprising the following method stages: a first application stage (AI) in which a decorative paper (1) is provided with an impregnation (2) containing a first synthetic resin, a second application stage (AII) in which a layer (4wet) which contains a second synthetic resin and particulate abrasion-reducing material is applied to the moist impregnate (3wet), a first treatment stage (BI) in which a heat treatment for partial curing of synthetic resins and for partial removal of the moisture from the moist coated impregnate (5wet) is effected, a third application stage (AIII) in which the application of a cover layer (6wet) containing a third synthetic resin is effected, and a final second treatment stage (BII) in which a heat treatment for removing the moisture is effected.
US08470121B2 Method for mutually adhering moulded articles of vulcanized rubber and of polymer
The invention relates to a method for mutually adhering a first moulded article of an at least partially vulcanized rubber polymer and a second moulded article of a polymer. The method comprises at least the steps of providing a first moulded article of a rubber polymer which comprises a compound containing carboxylic acid anhydride; providing a second moulded article of a polymer; providing an adhesive composition comprising at least a polyisocyanate, a polyol and a catalyst; arranging an adhesive layer of the adhesive composition on the surface for adhesion of at least one moulded article; bringing the surfaces for adhesion together under pressure; and polymerizing at least the adhesive layer at a suitable temperature.
US08470119B2 Use of a leguminous starch in an adhesive labeling composition
The invention relates to the use of a native or modified leguminous starch for producing an adhesive labeling composition. Said leguminous starch has an amylose content ranging between 25 and 60 percent by weight (dry/dry) and can be embodied as pea starch, especially pea starch having an amylose content of at least 30 percent but less than 50 percent by weight. The adhesive composition can advantageously be used for labeling glass or plastic bottles and can contain another natural polysaccharide polymer or protein polymer in addition to the leguminous starch, for example another native or modified leguminous or non-leguminous starch, particularly a starch having an amylopectin content of at least 80 percent by weight (dry/dry). The use of a leguminous starch makes it possible to obtain labeling adhesives, optionally highly dry (>40%) substances, which have excellent characteristics regarding stability during storage, rheology, and water resistance.
US08470111B2 Method for production of thin sheet metal
A composite component comprising at least one first and one second sheet metal plate with at least one layer of a polymer arranged between the first and the second sheet metal plates provides for a component optimized with respect to the weight thereof, and which is at the same time simple to manufacture. The polymer layer of the composite component according to the invention comprises at least one foamed polymer layer of a thermoplastic polymer, wherein the foamed polymer layer comprises gas bubbles with a volume percentage of 1% to 80%, in particular 5% to 70%.
US08470102B2 Process for manufacturing a galvanized or a galvannealed steel sheet by DFF regulation
The invention deals with a process for manufacturing a hot-dip galvanized or galvannealed steel sheet having a TRIP microstructure, said process comprising the steps consisting in: -providing a steel sheet whose composition comprises, by weight: 0.01≦C≦0.22%, 0.50≦Mn≦2.0%, 0.2≦Si≦2.0%, 0.005≦Al≦2.0%, Mo<1.0%, Cr≦1.0%, P<0.02%, Ti≦0.20%, V≦0.40%, Ni≦1.0%, Nb≦0.20%, the balance of the composition being iron and unavoidable impurities resulting from the smelting, -oxidizing said steel sheet in a direct flame furnace where the atmosphere comprises air and fuel with an air-to-fuel ratio between 0.80 and 0.95, so that a layer of iron oxide having a thickness from 0.05 to 0.2 μm is formed on the surface of the steel sheet, and an internal oxide of Si and/or Mn and/or Al is formed, -reducing said oxidized steel sheet, at a reduction rate from 0.001 to 0.010 μm/s, in order to achieve a reduction of the layer of iron oxide, -hot-dip galvanising said reduced steel sheet to form a zinc-coated steel sheet, and -optionally, subjecting said hot-dip coated steel sheet to an alloying treatment to form a galvannealed steel sheet.
US08470096B2 Paint bell cup cleaning method
A method for cleaning a bell cup after its removal from a rotary paint atomizer. A device is provided that preferably includes an enclosure within which the bell cup is retained during the cleaning operation. Pressurized cleaning fluid is introduced into the enclosure where it flows over the bell cup and removes paint therefrom. The enclosure may be connected to the nozzle end of a paint spray gun that can be used to deliver the pressurized cleaning fluid thereto.
US08470095B2 Process and installation for surface preparation by dielectric barrier discharge
A process for surface preparation of a substrate (2), which comprises introducing or running a substrate (2) into a reaction chamber (6, 106). A dielectric barrier (14, 114) is placed between electrodes (1, 10, 110). A high-frequency electrical voltage is generated, to generate filamentary plasma (12, 112). Molecules (8, 108) are introduced into the reaction chamber (6, 106). Upon contact with the plasma, they generate active species typical of reacting with the surface of the substrate. An adjustable inductor (L) placed in parallel with the inductor of the installation is employed to reduce the phase shift between the voltage and the current generated and to increase the time during which the current flows in the plasma (12, 112).
US08470092B2 Method and apparatus for fast and local anneal of anti-ferromagnetic (AF) exchange-biased magnetic stacks
A method (and structure) of thermally treating a magnetic layer of a wafer, includes annealing, for a predetermined short duration, a magnetic layer of a single wafer.
US08470088B2 Cast bodies, castable compositions, and methods for their production
A low-water-content castable composition produces cast products with an increased modulus of rupture, an increased cold crushing strength, and decreased porosity. The composition employs closed fractions of constituent particles with specified populations and specified gaps in the particle size distribution to produce these properties. The composition is suitable for refractory applications.
US08470086B1 Composition for application as a coloring agent to mortar
A mixture of linseed oil, paint thinner and pigment, blended in specified combination, is prepared for application to mortar—particularly old mortar—as a coloring agent. The mixture is suitable for use at repair sites comprising both old mortar and new mortar applied in making repairs, provided the new mortar has been allowed to age for at least 60 days.
US08470084B2 Electric precipitator and high voltage electrode thereof
An electrode precipitator having a high voltage electrode and a low voltage electrode arranged apart from each other at a desired interval. The high voltage electrode includes a charging part which is positioned upstream of an air flow direction to charge a pollutant, and a dust collection part which is spaced from the charging part and positioned downstream of the air flow direction to precipitate the charged pollutant therein.
US08470083B2 Portable canister vacuum
A portable handheld canister vacuum including an upper, central, and lower housing is disclosed. First and second grills can separate the housing sections. An air intake opening can direct air and dirt in a first axial direction to a dirt capturing device in the lower housing. An air propulsion device directs air in a second axial direction opposite to the first axial direction into the central housing and from there into the upper housing. An exhaust opening disposed through the upper housing and leading to the interior region of the upper housing allows air to exit the interior region of the upper housing. The exhaust can exit the upper housing in a direction substantially perpendicular to the first and second axial directions.
US08470082B2 Systems using mass flow promoting insert with gas purging and methods thereof
A system in one embodiment includes a barrier; an inverted cone in the barrier; and a member under the inverted cone and having dimensions that cause solids passing therealong between the member and the barrier to have about a constant velocity profile thereacross. A method for purging a gas from a solid/gas mixture according to one embodiment includes adding solids to a barrier having an inverted cone therein and a member under the inverted cone, wherein the solids passing along the member have about a constant vertical velocity profile thereacross; and injecting a purge gas into the solids from at least one point adjacent the member.
US08470079B2 Separating CO2 from gas mixtures
The present invention relates to a process for separating off CO2 from a gas stream, wherein in a second step the CO2 is removed from the CO2-absorbing agent by means of phase separation.
US08470071B2 Enhanced HVAC system and method
Particular embodiments disclosed herein relate to methods, compositions, and systems relating generally to heating, ventilation, and air conditioning (HVAC) systems, and more specifically, to HVAC systems that transfer sensible and/or latent energy between air streams, humidify and/or dehumidify air streams. In certain embodiments, a polymeric membrane is utilized for fluid exchange, with or without an additional support. Certain embodiments allow for individual regulation of air temperature and humidity.
US08470067B2 Process for preparing a foaming slag former, product and use thereof
Process for preparing a foaming slag former for electric furnaces comprising the steps of aggregating solid slag particles into a coarser granular material and carbonating the solid slag particles to form the foaming slag former. The solid slag particles are preferably aggregated before carbonization, so that the carbonates form a solid matrix binding the particles together.
US08470065B1 Manufacturing of bioorganic-augmented high nitrogen-containing inorganic fertilizer
The invention describes a new method for the production of high nitrogen organically-augmented inorganic fertilizer that incorporates municipal biosolids or organic sludges that can compete with traditional fertilizers such as ammonium phosphate, ammonium sulfate and urea on the commodity fertilizer marketplace. The method creates a thixotropic paste-like material from the biosolids or organic sludge that is blended with hot or molten ammonium salts, especially a mixture of ammonium phosphate and ammonium sulfate. The invention can be an add-on to commercial production of ammonium salts or it can stand alone by manufacturing ammonium salts prior to their introduction to the conditioned biosolids. The invention is oriented to be tailored to production facilities for individual municipal waste treatment plants in order to keep manufacturing plants small with a minimization of logistics and liability.
US08470063B1 Chimney filter system
A chimney filter system featuring two or more filter housings mounted atop an industrial chimney stack and a reservoir fluidly connected to the lower filter housing via a first drain pipe that allows water to flow from the lower filter housing to the reservoir. The reservoir allows contaminants in the water to collect on the bottom surface of the reservoir. A second drain pipe is fluidly connected to the reservoir via a pump. The pump and second drain pipe deliver water from the reservoir to the upper filter housing.
US08470061B2 Non-abrasive back coat for coated abrasives
An abrasive article includes a backing including first and second major surfaces, an abrasive layer disposed over the first major surface, and a back coat layer disposed over the second major surface. The back coat layer includes a polymeric material and a fabric.
US08470057B2 Method for producing alkaline primary battery
A method for producing an alkaline primary battery includes: (1) forming a cylindrical positive electrode having a hollow; (2) inserting a cylindrical separator with a bottom into the hollow of the positive electrode, the separator including: a wound cylindrical portion; and a bottom portion that is substantially U-shaped in cross-section, the bottom portion covering an opening of the cylindrical portion at a lower end thereof and having an upstanding portion that extends along a lower outer face of the cylindrical portion; and (3) injecting an electrolyte into the separator. The amount of the electrolyte injected into the separator in the step (3) is sufficient to impregnate the positive electrode and the separator and immerse a lower end of the cylindrical portion of the separator in the electrolyte remaining in the separator, thereby bringing the lower end of the cylindrical portion into contact with the upstanding portion.
US08470055B2 Combined process for preparing calcined soda by applying surface engineering technology to natural soda preparation
The invention relates to a combined process for preparing a calcined soda from a natural soda containing sodium chloride, soda and sodium sulphate, which comprises steps: (a) dissolving the natural soda to prepare an aqueous solution; (b) obtaining sodium carbonate decahydrate crystals from the natural soda solution by using a separation method of attaching crystallization; and (c) treating the obtained sodium carbonate decahydrate crystals to obtain the calcined soda. The selection to raw materials in the combined process is widened, and the associated minerals, such as sodium chloride, soda and sodium sulphate, can be separated as simple substances. The species of the obtained calcined soda and anhydrous sodium sulphate are abundant, and their purities are high. Moreover, the entire processes can be recycled, and there is no discharge of smoke, dust, waste liquid and so on.
US08470053B2 Compositions for laundering and subsequently drying delicate garments without incurring any damage and methods to use them
The present invention relates to compositions and methods for wet-cleaning, in professional or household washing machine equipment, and subsequent drying in a tumbler dryer, of garments made of protein-fibers (animal based fibers) such as wool, cashmere, silk and other sensitive fibers. Using water and certain additives instead of organic solvents, these compositions enable the cleaning, including oil stains removal, and subsequent drying without incurring dimensional changes, shrinkage, surface damages, dye or color loss of dry clean only labeled garments or other delicate garments labeled for special care.
US08470051B2 One motor finger mechanism
A mechanical finger comprises a plurality of phalanges coupled to a single actuator using a kinematic linkage and a differential linkage arranged in parallel. The mechanical finger is capable of exhibiting consistent predictable motion when moving in free space or when contacting an object at the fingertip, and of curling in order to conform to an object when the contact is at other locations on the finger.
US08470048B2 Prosthesis for simulating natural kinematics
A bearing component 2 for a joint replacement prosthesis comprises a first bearing element 4; a second bearing element 6, and a linking element 8, operatively connecting the first and second bearing elements 4, 6 and permitting relative motion there between. The flexible linking element 8 prevents dislocation of mobile bearings in a total knee replacement prosthesis. The invention also relates to a bridging element which retains the linking element 8 with some play, which acts as a ligament support 2051, and which causes a deflection of the line of action of a ligament 1018. A joint replacement prosthesis is also disclosed comprising a biasing element 1140 or a tensioning element 1220 operatively coupled to the artificial ligament 1018. The biasing element 1140 or tensioning element 1220 may be housed in the stem of a tibial tray 1006.
US08470041B2 Two-component artificial disc replacements
Artificial disc replacements (ADRs) and total disc replacements (TDRs) are based upon two, directly articulating components, resulting in a restricted-motion system that better approximates more normal spinal flexion, extension, and lateral bending. One component may have a concave articulating surface, and the other a convex articulating surface. The radius of curvature of the articulating surface may be smaller in the anterior-to-posterior direction of the ADR than the radius of curvature of the articulating surface in the left-to-right direction of the ADR. Both components are preferably made of a hard material and are highly polished to reduce friction.
US08470038B2 Adjustable and fixed assembled bone-tendon-bone graft
The present invention relates to a bone-tendon-bone graft and components. Embodiments of the present invention comprise an intermediate bone block that is used to adjustably secure soft tissue (e.g., tendon) in a patient. Embodiments of intermediate bone blocks of the present invention are used singly or in combination with one or more bone blocks to form a bone block assembly for securing soft tissue. The present invention further relates to an assembled bone-tendon-bone graft for implantation in humans comprising the intermediate bone block and a length of soft tissue. A bone-tendon-bone graft comprises a length of soft tissue extending from a first assembled bone block to a second bone block and then doubles back to said first assembled bone block. Depending upon the embodiment, the second bone block fixedly or slideably attaches to the length of soft tissue and facilitates it doubling back to the first assembled bone block.
US08470037B2 Method and apparatus for reconstructing a ligament
A system for reconstructing a ligament by fixing at least one graft ligament strand in a bone tunnel is provided. The system a retainer configured for disposition in the bone tunnel, the retainer including a crosshole for receiving a locking pin and a mounting shoulder formed about the crosshole, and a cap removably attached to the retainer for capturing the at least one graft ligament strand by compressing the at least one graft ligament strand between the cap and the retainer, wherein the cap includes at least one locking member configured to engage the mounting shoulder of the retainer to facilitate gripping of the at least one graft ligament strand between the cap and the retainer.
US08470036B2 Method and apparatus for reconstructing a ligament
Apparatus for use in supporting a graft ligament within a bone tunnel, the apparatus comprising a graft ligament plug, the graft ligament plug comprising a groove extending along one side of the plug, across the front end of the plug, and then back down the opposing side of the plug, with the groove being sized such that when a graft ligament is disposed in the groove, the graft ligament will protrude out of the groove and engage adjoining portions of the bone tunnel so as to facilitate osseointegration therewith; wherein the graft ligament plug is formed in two opposing halves, such that the graft ligament can be positioned within the groove and thereafter clamped between the opposing two halves of the graft ligament plug when the two opposing halves are brought together so as to form the complete graft ligament plug.
US08470035B2 Hydrogel filaments for biomedical uses
Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations with radiopaque hydrogel filaments with delayed controlled rates of expansion permitting the repositioning of the device once inside the structure or malformation. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.
US08470033B2 Flexible intraocular implant with circular haptic
A flexible intraocular implant for placing in a capsular bag, the implant comprising an optical portion of substantially circular shape that presents an optical axis, and a haptic portion connected to the periphery of the optical portion, said haptic portion comprising: a contact portion constituted by n (n≧2) contact elements in the form of circular arcs all having the same radius of curvature and each having an outer edge that is in contact with the equatorial zone of the capsular bag, and n connection elements, each connection element being connected via respective ends to two consecutive contact elements, presenting a deformable curved shape, and presenting stiffness that is much less than that of the contact elements; and n deformable connection arms each connected to the periphery of the optical portion and to a contact element.
US08470022B2 Implantable valve
Described are implantable prosthetic valve devices comprising isolated granulation tissue. Also described are methods of treatment that include implanting at least one of these valves within a body passageway of a patient, for example, within a vein to treat venous insufficiency.
US08470015B2 Insertion system for deployment of catheter-based stent devices
An insertion system for release of a self-expanding stent device 18 in a body vessel has a first grip 33, which is fixedly connected to a shaft 15, a second grip 36, which is mounted on the shaft 15 to be movable in axial direction, a sheath 19, which, in a distal portion thereof, keeps the stent device radially compressed and which is fixedly connected to the second grip 36, and a retention element 17, which is fixedly connected to the shaft 15 and is guided in the sheath 19, wherein the retention element 17 holds the stent device 18 in its axial position relative to the first grip 33 when the sheath 19 is being retracted. Reference means 25 with an optical reference mark 26 are arranged for continuous monitoring of the axial position of the stent device 18.
US08470013B2 Systems and methods for aneurysm treatment and vessel occlusion
A system for treating an aneurysm includes an expandable barrier positionable to bridge an aneurysm neck. The barrier may comprise a fiber mesh, a balloon or a molly anchor member, and may unroll, unfold, or inflate from a compact configuration to an expanded configuration. Expansion of the barrier may be greater radially than axially. A vaso-occlusive member comprising a coil or balloon may be deposited in the aneurysm. Another aneurysm treatment system comprises an outer fenestrated stent and/or an inner fenestrated sleeve, which may be implanted together adjacent an aneurysm neck to regulate blood flow to the aneurysm. The sleeve may be movable relative to the stent to open or occlude the fenestrations, which may vary in size, shape, and distribution. An intra-luminal vessel occlusion device comprises a stent and a sheath. A drawstring may be actuated to gradually close a sheath orifice to control blood flow through the vessel.
US08470012B2 Inflatable convective pad for surgery
An inflatable convective pad for warming a person during surgery has two ends, two sides, and at least two openings, each located in an area of the pad between the two ends and between a respective side and the center of the pad. The openings, which may be in the form of slits, allow the threading of a sheet or the person's arms through the pad to restrain the arms during surgery.
US08470009B1 Bone fastener and method of use
A bone fastener comprises a proximal portion including an inner surface that defines a cavity. A carrier is disposed in fixed engagement with the inner surface. A pivoting member is disposed with the carrier and relatively moveable therefrom. A distal portion defines a longitudinal axis and is configured to penetrate tissue. The proximal portion is rotatable relative to the distal portion in a first plane of a body and the pivoting member is rotatable relative to the proximal portion in a second plane of the body. Methods of use are disclosed.
US08470007B2 Antero-lateral plating systems and methods for spinal stabilization
A plating system for stabilization of a bony segment includes a plate engageable to at least first and second bony elements. For spinal stabilization, the plate is attached to the antero-lateral portions of at least first and second vertebrae and is structured to facilitate engagement of the plate to the vertebrae from an approach extending in the anterior-posterior directions.
US08470006B2 Bone repair systems
Bone treatment plate assemblies, methods of fabrication, and methods of use. Such assemblies comprise spring structures assembled to bone treatment plates. The spring structure comprises elongate bands, and springs between the bands, urging the bands against structure of the plate. Spring width is less than spring height and/or one or more protuberances extending from the band or bands cooperate with one or more detents in the plate thereby to arrest longitudinal movement of the spring structure with respect to the plate.
US08470005B1 Hip nail support assembly
The assembly supports the trailing end of a lag screw or hip nail device being used to immobilize a hip fracture, and enables the compression of the fractured bone ends together, thereafter enabling sliding of the femoral head together with the lag screw or hip nail laterally, while simultaneously limiting their rotation, thereby promoting healing of the fracture.
US08470003B2 Laminoplasty plates and methods of expanding the spinal canal
A method of expanding the spinal canal of a vertebra including inserting a bone anchor into a first lamina of the vertebra, cutting completely through the first lamina to create a space in the first lamina, cutting partially through a second, contra-lateral lamina of the vertebra to create a partial cut in the second lamina, engaging a first segment of a plate with the bone anchor, pivoting the bone anchor and the first lamina about the partial cut in the second lamina to increase the extent of the space in the first lamina, and connecting a second segment of the plate to a portion of the vertebra across the space from the first segment of the plate such that the plate spans the space and stabilizes the vertebra.
US08470002B2 Resorbable release mechanism for a surgical tether and methods of use
The present application is directed to tethers and methods of use. The tether is attached with anchors to bony members within the patient. The tether applies a tensile force to the bony members to reduce and/or eliminate the abnormality of the bony members. The tether includes a release mechanism with a resorbable material that initially maintains the tether in a shortened orientation. The release mechanism is eventually releases the tether to a lengthened orientation. The release mechanism may prevent the need for a subsequent surgery to release tension from the tether as the patient grows.
US08470000B2 Interspinous vertebral and lumbosacral stabilization devices and methods of use
Implantable devices are provided for stabilizing adjacent vertebrae and the lumbosacral region of a patient. The devices can comprise an interspinous flexible spacer body having a substantially U-shape comprising a superior section, inferior section, and a midsection extending therebetween. The superior and/or inferior sections can include a pair of lateral walls configured to engage a spinous process of a vertebra. Fixation caps can be provided for securing a spinous process of a vertebra to the flexible spacer body. To secure the flexible spacer body between the lumbar vertebra and an adjacent vertebra, an anchor assembly is provided. Also provided are methods of using the implantable devices to stabilize a patient's spine.
US08469996B2 Prosthesis and method for lowering abdominal pressure
A two-sheet fascial expander prosthesis for temporary use and method of using it to treat abdominal hypertension and associated organ system function impairment, in which each flat sheet is attached to the fascia only at opposite sides of an incision. One side of each sheet is armed with mating fastening elements that bond when united to bring about high tensile shear strength and low tensile peeling-off resistance permitting easy separation for diagnostic and therapeutic abdominal entry. The invention is useful because it expands the fascia and adds compliance to the envelope of the abdominal cavity by bridging the gap between free borders of the incised fascia containing intra-abdominal organs without strangulating their blood supply and retaining some tension on the fascia to prevent retraction and bringing the edges closer together as healing progresses, and permitting final removal of the patch and fascia-to-fascia closure. The method of producing and testing biocompatibility of the two-sheet fascia prosthesis also is disclosed.
US08469994B2 Connective tissue closure device and method
A device for closing wounds such as openings in blood vessels as well as a method of doing so are disclosed. The device employs a fabric wrapped around an expandable frame both of which are inserted into a blood vessel through a introducer sheath. Once inserted, the expandable frame expands thereby expanding the fabric therewith. The fabric is made from a bioabsorbable material and includes a plurality of microhooks extending therefrom. One suitable material is polylactic acid fiber. Upon retraction of the device, the microhooks engage the adventitia surrounding the blood vessel causing the fabric to remain in position sealing the opening even after the expandable member is retracted and removed as well as the introducer sheath. As the fabric is made from a bioabsorbable material, the device can remain in place even after hemostasis is reached and eventually dissolve within the body.
US08469992B2 Apparatus for performing an electrosurgical procedure
An endoscopic forceps is provided. The endoscopic forceps includes a housing having a shaft that extends therefrom and defines a longitudinal axis therethrough. An end effector assembly operatively connects to a distal end of the shaft and has a movable jaw member and a non-movable jaw member. The movable jaw member has a substantially flexible medial portion and is movable relative to the non-movable jaw member from an initial position for positioning tissue therebetween, to a subsequent or clamping position wherein the movable and non-movable jaw members cooperate to grasp tissue therebetween. A drive assembly is operably coupled to the housing and includes a drive wire that operably couples to the movable jaw member. Proximal movement of the drive rod causes the medial portion of the movable jaw member to flex inwardly along a substantial length thereof and toward the non-movable jaw member.
US08469989B2 Pushable coaxial balloon catheter
Coaxial balloon catheters are described herein. The balloon catheter can include outer and inner tubes in a coaxial relationship, with a balloon attached to an end thereof. A support sleeve can be disposed around the inner tubular member proximate the proximal end of the balloon. The support sleeve can have a channel formed therein to communicate with an inflation lumen and a balloon interior. The channel may be formed by separation of two longitudinal edges extending through the support sleeve. The support sleeve can include an outward extending portion that is sized to engage the distal end of the outer tube in order to limit relative movement between the inner and outer tubes. The support sleeve can be configured to orient the inner tube eccentrically or concentrically relative to the outer tube. The support sleeve can have an elongate body that can be extended in proximal or distal direction.
US08469988B2 Nut carrier for body piercing instrument
Apparatuses and systems for ornamental piercing of body parts are disclosed. Various embodiments of the invention employ a nut carrier which includes a vertical engagement feature and molded spring fingers to couple to a body piercing instrument. The vertical engagement feature prevents rotation of the nut carrier relative to the body piercing instrument and the molded spring fingers provide a secure engagement over a rounded flange of the body piercing instrument. The nut carrier is implemented as a component in a body piercing system that employs separate carriers for the nut and the post. The novel nut carrier simplifies manufacturing eliminating a welded two part flange previously employed in the body piercing instrument.
US08469985B2 Puncture instrument
A puncture instrument includes a movable body movably disposed in a case, and a needle unit held by the movable body and having a needle. When a distal end face of the movable body is brought into abutment against a region to be punctured and the case is advanced toward the region to be punctured, the case is advanced together with the needle unit, and the tip end of the needle becomes protruded from the movable body and punctures the region to be punctured. An arm of the needle unit is abutted against and turned about a fulcrum member, thereby withdrawing the needle rearwardly.
US08469984B2 Single use lancing device
A lancing device comprises a housing, a trigger button, a drive spring and a protective cap. The housing forms an aperture and an opening opposite thereof. A lancet partially extends through the aperture. The trigger button is located near the opening. At least a portion of the trigger button is external to the housing. The drive spring is attached to and connects the lancet and the trigger button. The drive spring moves the lancet from the cocked position to the puncture position. The protective cap is removeably attached to the lancet opposite the drive spring and engages the housing when the cap is removeably attached to the lancet. The cap prevents the drive spring from moving the lancet to the puncture position prior to removing the cap from the lancet.
US08469983B2 Devices and methods for remote suture management
Described here are devices and methods for suture management. In some variations, the devices comprise an elongate tubular member having a proximal end, a distal end, a lumen therebetween, a cantilever blade positioned near the distal end of the elongate tubular member, and an expandable member positioned adjacent the cantilever blade for actuating the cantilever blade. Also described are devices comprising an elongate tubular member having a proximal end, a distal end, a lumen at least partially therebetween, and an aperture in a wall thereof for passage of a suture therethrough. These devices further comprise a blade connected to a blade housing disposed within the lumen, where the blade is oriented parallel to the longitudinal axis of the lumen. The blade and blade housing may be slidable within the lumen, or an inner shaft for may be slidable within the lumen. Methods of using the devices are also described.
US08469979B2 High capacity debulking catheter with distal driven cutting wheel
An atherectomy catheter with a rotary cutting element is provided. The catheter collects plaque shavings in a hollow collection chamber. The catheter includes a drive shaft connected between a source of rotational power and the distal side of the cutting element, no part of the drive shaft being contained within the collection chamber.
US08469977B2 Endoscopic plication device and method
Described herein are endoscopic plicators passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. In the disclosed embodiments, the tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The disclosed plicators allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver sutures, staples or other means for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparoscopic intervention. After one or more plications is formed, medical devices may be coupled to the plication(s) for retention within the stomach.
US08469975B2 Method and apparatus for applying a knot to a suture
A knot placement device allows a physician to apply a knot for securing two or more suture ends extending from an incision in a vessel or organ of a patient relative to each other in order to seal an opening in the vessel or organ. The knot placement device has a handle, an elongate shaft, and a push rod slidably inserted in the shaft. A knot is disposed in the distal end of the shaft. An actuator on the handle may be depressed to distally advance the push rod relative to the shaft, thereby distally advancing the knot. The knot may include a knot body having an inner cavity and a plug sized to fit securely within the inner cavity. In use, the plug may be inserted into the inner cavity of the knot body to fixedly hold two or more suture ends between the knot body and the plug.
US08469974B2 Method and apparatus for treating a hip joint, including the provision and use of a novel suture passer
A suture passer including a shaft having an axis; a first jaw mounted to the shaft in alignment with the axis, the first jaw being configured to releasably support a length of suture thereon; a second jaw movably mounted to the shaft; and a needle movably mounted to the shaft, the needle having a hook and being configured to reciprocate in alignment with the axis so that the hook can selectively pass by the second jaw and engage suture releasably supported on the first jaw; wherein the first jaw includes a spring for selectively binding the suture to the first jaw.
US08469973B2 Apparatus and method for sternotomy closure
A tissue closure device includes a pusher assembly having a drive arm extending from a drive shaft and a drive mechanism at a distal end of the drive arm, wherein the drive mechanism is capable of releasably engaging and rotating a suturing needle having a pointed end and a blunt end about a rotational axis and a cartridge having a protective housing and the suturing needle, the cartridge extending from a distal end of a cartridge holder assembly and releasably attached to the cartridge holder assembly. A pointed end of the suturing needle may be positioned within the protective housing before and after a complete rotation of the suturing needle about the rotational axis. A removable electronic module may be provided controlled by an actuator that mechanically engages the drive shaft to rotate the drive shaft and the drive mechanism, thereby rotating the suturing needle about the rotational axis.
US08469968B2 Methods of treatment with drug delivery after biodegradation of the stent scaffolding
Disclosed is a stent comprising a bioabsorbable polymeric scaffolding; and a plurality of depots in at least a portion of the scaffolding, wherein the plurality of depots comprise a bioabsorbable material, wherein the degradation rate of all or substantially all of the bioabsorbable polymer of the scaffolding is faster than the degradation rate of all or substantially all of the bioabsorbable material of the depots.
US08469964B2 Bone cutting template and method of treating bone fractures
A bone cutting template is disclosed and can include a body. A plurality of grooves can be formed along the body and each groove can correspond to an incremental length of the body. The bone cutting template can include a plurality of length stamps along the body. Each of the plurality of length stamps can be adjacent to a corresponding groove.
US08469963B2 Bone drilling cannula
A drilling guide cannula, having a serrated distal end in the form of axially moveable teeth which enables all or most of the teeth to maintain biting contact with the bone surface, essentially independently of the curvature of the bone surface and the drilling angle. The cannula outer wall incorporates a number of pins arranged circumferentially around the drilling bore. These pins slide axially relative to the cannula, preferably in bored holes or in channels formed within the wall of the cannula. Each of the secondary pins has a sharpened distal end, each constituting a moveable tooth. The cannula is applied to the bone to be drilled at the desired drilling position and angle, and the pins are forced axially towards the bone surface. The pins take up the contour of the bone surface and each pin bites into the bone surface to rigidly position the drilling guide cannula.
US08469961B2 Methods and compositions for minimally invasive capsular augmentation of canine coxofemoral joints
The present technology relates to methods and devices for augmenting the canine coxofemoral joint. In particular, methods for augmenting the capsule of the canine coxofemoral joint are provided. In some embodiments, augmentation can be performed by injecting an implantable device comprising a biodegradable matrix and microparticles into the capsule. In some embodiments, augmentation can be performed by imbricating an implantable device comprising a biodegradable matrix and microparticles at the capsule.
US08469960B2 Systems and methods for spinal fixation
A spinal stabilization system, method, and a surgical kit having a surgical extender apparatus for implanting a surgical screw are disclosed. The extender includes a housing having a distal end and a proximal end, a hollow interior passageway disposed between the distal end and the proximal end, a channel disposed along an exterior surface of the housing at least partially between the distal end and the proximal end and configured to at least partially expose the hollow interior passageway, an interior locking mechanism disposed on an interior surface of the housing and substantially adjacent the proximal end, wherein the interior locking mechanism is configured to allow attachment of at least one surgical tool, and at least one flexible member disposed substantially adjacent the distal end. The housing is configured to accommodate placement of a surgical screw implant. The surgical screw implant is secured to the housing using a mating feature in the surgical screw implant. The at least one flexible member is configured to retain the surgical screw implant. The mating feature is configured to control axial movement of the surgical screw implant.
US08469957B2 Apparatus, system, and method for performing an electrosurgical procedure
The present disclosure provides a bipolar forceps adapted to connect to a source of electrosurgical energy for performing an electrosurgical procedure. The bipolar forceps includes a housing having a shaft that extends therefrom. The bipolar forceps is in operative communication with one or more vacuum sources. The bipolar forceps includes an end effector assembly having a pair of first and second jaw members biased in an open configuration; each jaw member including a respective seal plate. The pair of first and second jaw members is operatively and pivotably connected to a distal end of the shaft. One or both of the first and second jaw members includes one or more apertures in fluid communication with the distal end of the shaft and the one or more vacuum sources.
US08469955B2 Tissue separating catheter assembly and method
A tissue-separating catheter assembly comprises a rotatable shaft, having a distal shaft portion, and a tissue separator device extending along the shaft. The tissue separator device has a distal separator part at the distal shaft portion movable between a retracted state, towards the distal shaft portion, and an outwardly extending, operational state, away from the distal shaft portion. A pivot joint may be used to pivotally connect the distal separator end to the distal shaft portion. The distal shaft portion may comprise a distally-facing transition surface at a proximal end of the distal shaft portion. First and second energizable tissue separator elements may be used at the transition surface and the tip of the device, respectively.
US08469953B2 Twin sealing chamber hub
Devices and methods for cooling microwave antennae and microwave hub construction are disclosed herein. The cooling system and hub can be utilized with a variety of microwave antenna types. A microwave hub is utilized to provide cooling fluids to a microwave antenna. The hub is constructed using no glue or adhesive for holding the different parts of the chambers in place. O-rings provide an increased reliability and consistency for fluid-tight seals in the hub. The various parts of the hub are form fitted and work together with the o-rings.
US08469949B2 Hair-removal device using pulsed electromagnetic radiation
The hair-removal device comprises a housing, a flashlamp arranged inside the housing, the housing having an opening through which electromagnetic energy originating from the flashlamp can be transmitted towards a skin surface.The housing comprises: a cavity adjacent to the flashlamp; at least one aeration orifice; and at least one mobile component in the housing, which can be displaced between a first so-called aeration position, in which said cavity communicates with said aeration orifice and a second so-called closed position, for which said cavity is closed in order to limit the light escaping from the opening. Said mobile component can be formed by a housing portion that can close the cavity except for the opening, by moving towards a complementary housing portion.
US08469947B2 Wireless communication in a robotic surgical system
In one embodiment, an insertion axis of a robotic manipulator is provided, the insertion axis including a base link operably coupled to a distal end of a manipulator arm, and a carriage link movably coupled to the base link along a lengthwise axis, the carriage link including a remote printed circuit assembly and transceiver for wirelessly communicating with a main printed circuit assembly external to the insertion axis. A robotic surgical system including such an insertion axis and a method for wireless communication in the system are also provided.
US08469945B2 Center robotic arm with five-bar spherical linkage for endoscopic camera
A robotic arm including a parallel spherical five-bar linkage with a remote center of spherical rotation. The robotic arm movably supports an endoscopic camera. Two outboard links are pivotally coupled together. At least one of the two outboard links supports the endoscopic camera. Two inboard links are respectively pivotally coupled to the two outboard links such that the two inboard links are able to cross over one another. The two inboard links moveably support the two outboard links. A ground link is pivotally coupled to the two inboard links. The ground link moveably supports the two inboard links.
US08469943B2 Coated implantable medical device
A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
US08469937B2 Method of manufacturing absorbent articles containing elastics
A method of manufacturing absorbent articles having an absorbent core (18,20,22) enclosed between casing sheets (16,24) and elastic elements (26-28) located in a front part and/or rear part of the article, includes the steps of laying a row of absorbent cores (18,20,22) on a first web (16) of casing material running in a machine direction with the longitudinal direction of the cores being extended in the machine direction, applying a second web (24) of casing material onto the web containing the row of absorbent cores, applying elastic elements (26-28) to one of the webs before it contacts the row of absorbent cores, thereby forming a row of connected absorbent article blanks, and thereafter cutting individual absorbent articles out of the row of article blanks.
US08469934B2 Pulsatile peri-corneal drug delivery device
The present invention is directed to a pulsatile ophthalmic peri-corneal drug delivery device. The device includes an annular body and a mechanism for releasing multiple separate and distinct doses of a therapeutic composition over an extended period of time.
US08469930B2 Dosing unit, ambulatory infusion device comprising dosing unit and method for operating a dosing unit
A dosing unit for an ambulatory infusion device and a method of operation are disclosed. The dosing unit includes a stationary member, a movable member, and a plunger. The movable member and the stationary member, together, make a charging valve and a discharging valve. The plunger is located, at least in part, in a metering cavity of the movable member and the movable member is adapted to selectively couple and decouple a driving unit, such that, by operating the driving unit with the movable member being coupled with the driving unit, the movable member moves with the plunger to maintain a position of the plunger relative to the movable member along a displacement axis, and by operating the driving unit with the movable member being decoupled from the driving unit, the plunger is displaced while the position of the movable member is maintained.
US08469927B2 Fluid flow control device with retractable cannula
A device having a housing; a cannula projecting forwardly from the housing; a connector useful for attaching the device to a fluid source or receptacle; a fluid flow path establishing fluid communication between the cannula and the connector; a retraction mechanism biasing the cannula away from its projecting position; and an actuator supported by the housing and configured to modify the fluid flow path so as to terminate fluid flow through the device, seal off the fluid flow path, and release the retraction mechanism to retract the cannula into the housing. The subject device is particularly preferred for use in the medical field, for example, as part of an infusion set or as a collection device for blood, or other fluids or flowable matter.
US08469926B2 Non-compliant medical balloon having an integral non-woven fabric layer
A non-compliant medical balloon may be changed from a deflated state to an inflated state by increasing pressure within the balloon. The non-compliant medical balloon is composed of randomly oriented fibers forming an angle. The angle remains substantially unchanged when the balloon changes from a deflated state to an inflated state.
US08469925B2 Balloon catheter including multiple chamber balloon with varying radius
A catheter assembly may comprise a guide catheter, a balloon catheter with a steering balloon and a stabilizing balloon and a guide wire. The stabilizing balloon secures the balloon catheter to the guide catheter while the steering balloon secures the catheter assembly to the vessel wall. In another embodiment, the balloon catheter has three balloons engaged to the exterior surface, a steering balloon, a stabilizing balloon and an anchoring balloon.
US08469923B2 Cartridge for powder and liquid drug
A cartridge or injector for holding and mixing a medical product is provided herein including a tubular body having a cylindrical wall having first and second opposing ends. The wall includes inner and outer surfaces with the inner surface having a generally constant cross-section along at least a drug mixing area. A first stopper is slidably disposed within the wall between the first and second ends, the first stopper defining a liquid-tight seal with the inner surface. A second stopper is slidably disposed within the wall between the first stopper and the first end, the second stopper defining a liquid-tight seal with the inner surface. A flexible insert is disposed at or in proximity to the second end, the insert forming a liquid-tight seal with the wall, the insert being pierceable by a medical needle or other piercing instrument. A rigid retainer is fixed to the wall having an opening therein for providing access to the insert for piercing by a medical needle. The insert extends into the retainer and forms a liquid-tight seal across the opening. Advantageously, with the subject invention, a reconstitution assembly may be provided which has a sufficiently large distal opening during assembly which allows a dry component to be introduced into the device in a dry state.
US08469915B2 Device for treatment of wounds using a wound pad and a method for manufacturing of wound pads
A device for treatment of wounds using reduced pressure is provided. The device includes a pump, a reservoir connected to said pump for collecting exudate from a wound, an inlet to the reservoir for connecting the reservoir with the wound so as to allow the pump to expose the wound to the reduced pressure, a wound pad to be arranged in the wound cavity, and a sealing covering the wound and the wound pad. The wound pad consists of an open-cell polyurethane foam which is fully impregnated with a soft hydrophobic silicone gel, and the foam has a hardness of 1.0-6.0 kPa measured according to ISO 3386-1 at at 40% compression The wound pad can be used with an absorbent member. A method is also provided for manufacturing the wound pad.
US08469912B2 Daneshvar wound dressing, support units and methods, model Daphne
A wrap for encircling a portion of a living body has a relatively non-stretchable support and a strap that has an attached zone attached to the support. The strap is relatively stretchable along its length as measured from that zone and long enough to encircle the portion of the living body and attach, with some stretching, back to an attachment means on the support for keeping the encircled portion of the body wrapped. The strap has relatively stretchable material that stretches with stretching of the strap and serves to attach the strap back to the attachment means on the support after having encircled the portion of the body.
US08469906B2 Therapeutic micro-vibration device
A therapeutic module for relieving pain and providing a curative healing effect includes a motor for rotating at least one magnet to generate a magnetic field, micro-vibrations and audible acoustic tones. A shaft couples the at least one magnet to the motor. The at least one magnet is coupled to the shaft in an offset configuration with respect to a centerline of the shaft thereby generating micro-vibrations in the form of oscillating inertial loads. The therapeutic module includes a light source for generating a photonic light field in an optical light spectrum.
US08469905B2 Ultrasonic foot massage machine
An ultrasonic foot massage machine is disclosed. The ultrasonic generator arranged inside the ultrasonic foot massage machine is connected with a first ultrasonic transducer and a second ultrasonic transducer that emit ultrasonic of different frequencies, respectively. The first ultrasonic transducer and the second ultrasonic transducer are connected with a first group of ultrasonic emitters and a second group of ultrasonic emitters, respectively. The ultrasonic frequency wave directly acts upon the foot sole, which can promote the blood circulation of the whole body and relax the human body, thus treating the pain produced by problem of vein athero-obstruction.
US08469904B2 Energetic modulation of nerves
A method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall.
US08469901B2 Method for diagnosing ADHD and related behavioral disorders
The invention features methods and systems for the diagnosis of ADHD and related disorders. The methods and systems of the invention can also be used to ascertain how much benefit an individual would derive from a particular therapy.
US08469899B2 Management of gastro-intestinal disorders
The present invention relates to the field of methods and apparatus for the determination of various conditions of gastric and gastro-intestinal malfunction, especially those performed by means of breath tests.
US08469895B2 Deriving central aortic systolic pressure and analyzing arterial waveform data to derive central aortic systolic pressure values
A method of deriving central aortic systolic pressure comprises (a) creating a set having a predetermined number of blood pressure measurements, the set representative of an arterial waveform; (b) determining an integer interval value; (c) averaging a series of consecutive blood pressure measurement readings in the set equal to the integer interval value commencing from the fth blood pressure measurement in the set; (d) storing the averaged value in a central aortic systolic pressure set; and (e) setting the central aortic systolic pressure as the highest value in the central aortic pressure set. Steps (c) and (d) are repeated with the value of f being incremented by 1 each time until the value of f plus the integer interval value equals the predetermined number of blood pressure measurements in the set.
US08469893B2 Portable ultrasound imaging system
A portable ultrasound imaging system includes a scan head coupled by a cable to a portable battery-powered data processor and display unit. The scan head enclosure houses an array of ultrasonic transducers and the circuitry associated therewith, including pulse synchronizer circuitry used in the transmit mode for transmission of ultrasonic pulses and beam forming circuitry used in the receive mode to dynamically focus reflected ultrasonic signals returning from the region of interest being imaged.
US08469889B2 Ultrasonograph that chooses tracking waveforms for attribute value calculations
An ultrasonic diagnostic apparatus includes: a transmitting section for driving a probe to send out ultrasonic waves toward a subject one after another; a receiving section for getting an echo, produced as a result of reflection of each ultrasonic wave from the subject, received by the probe, thereby generating a received signal; a tissue tracking section for generating position tracking waveforms, each representing the positional displacement of an associated one of measuring points on the subject, based on the received signals; a boundary detecting section for determining the boundary location of the subject's tissue; a tracking waveform choosing section for choosing at least two position tracking waveforms, including the one associated with the boundary, from the position tracking waveforms by reference to at least one of the waveforms associated with the measuring points, the location of the boundary, and the amplitudes of the received signals; and a tissue attribute value calculating section for calculating a tissue attribute value of the subject using the position tracking waveforms chosen.
US08469888B2 Formation of an enhanced elastic image in an ultrasound system
There are disclosed embodiments for forming an enhanced elastic image in an ultrasound system. An elastic image of a target object may be formed by scanning N scan lines. A control unit divides the N scan lines into M scan lines groups by using an acquisition period necessary for transmitting and receiving ultrasound signals to acquire ultrasound data. An ultrasound data acquiring unit transmits ultrasound signals to a target object and receives the ultrasound signals reflected from the target object at a predetermined transmission/reception sequence for each of the M scan line groups. This forms ultrasound data corresponding to each of the M scan line groups while a pressure is applied to the target object. An elastic image forming unit forms at least one sub elastic image corresponding to each of the M scan line groups based on the ultrasound data. The elastic forming unit sums M sub elastic images corresponding to the respective M scan line groups to thereby form an elastic image of the target object.
US08469884B2 Medical sensor kit for combination with a chair to enable measurement of diagnostic information
A medical examination chair kit includes a group of sensors including electrodes in finger-tip sensors, various other types of sensors incorporated in covers attachable or placeable on a chair and load cells on an adjustable grid supporting the chair, all of which provide data which is partially processed in a transmission pocket mounted on the chair.
US08469879B2 Capsule guiding system and capsule guiding method
A capsule guiding system includes a capsule medical device having an imaging device that takes an in-vivo image of a subject and a magnet with a magnetization direction that is relatively fixed with respect to the imaging device; a magnetic guiding device that applies a magnetic field to the magnet in the subject and guides the capsule medical device; a display unit that displays the in-vivo image of the subject; and a control unit that causes the magnetic guiding device to apply a magnetic field in a reference direction to the magnet, initializes a rotation angle of an image taken by the imaging device when the magnetization direction of the magnet is oriented to the reference direction following the magnetic field in the reference direction, performs, referring to the image, rotation correction on subsequent in-vivo images, and causes the display unit to sequentially display the corrected in-vivo images.
US08469878B2 Hood attachment jig
A hood attachment jig includes a holding member whose diameter is increasable and that holds an endoscope hood in a state where the holding member is inserted into the endoscope hood; a diameter increasing member that increases the diameter of the holding member by entering the holding member, so that the diameter of the endoscope hood increases; and a push-out member that, when an attachment operation is performed in a state where a tip portion of the endoscope enters the holding member with the increased diameter, pushes out the holding member and the endoscope to separate the holding member and the endoscope from the diameter increasing member so that the endoscope hood, a force of restitution of which reduces the diameter of the holding member, is brought into contact with an outer circumferential surface of the tip portion of the endoscope and further pushes out the endoscope to detach the endoscope from the holding member so that the endoscope hood is attached to the endoscope tip portion.
US08469877B2 System for introducing a pelvic implant
A system for supporting an anatomical structure of the pelvis includes a surgical implant for providing support to the anatomical structure of the pelvis. The surgical implant includes a first tissue anchor including a plurality of projections adapted for tissue fixation, a second tissue anchor including a plurality of projections adapted for tissue fixation, and a sub-urethral support having first and second ends, the first and second tissue anchors extending from the first and second ends of the sub-urethral support. The system also includes an introducer for delivering the first tissue anchor to a desired anchoring site of the pelvis.
US08469870B2 Swing rotor having improved holding pin for centrifugal separator and centrifugal separator including the same
A swing rotor for a centrifugal separator, the swing rotor including: a hub; and a rotor body disposed around the hub, wherein a plurality of pairs of arms are disposed at the rotor body, wherein a holding pin configured to hold a bucket is disposed to the arm, wherein an engagement portion which is configured to be supported by the holding pin is formed to the bucket, and wherein a sliding surface of the holding pin with an engagement portion of the bucket is formed such that a width of a contact area, which is an area that the holding pin contacts with the engagement portion of the bucket, in an axial direction when the bucket does not swing differs from a width of the contact area in the axial direction when the bucket reaches a horizontal position by swinging during a centrifugal separation operation.
US08469863B2 Rehabilitation exercising equipment that can extend a user's arms
A rehabilitation exercising equipment includes a main frame, a first geared member rotatably mounted on the main frame, a second geared member rotatably mounted on the main frame, a connecting mechanism mounted between the first geared member and the second geared member, a first idle geared member rotatably mounted on the main frame and connected with the connecting mechanism, a second idle geared member rotatably mounted on the main frame and connected with the connecting mechanism, and two handlebars secured on the first geared member and the second geared member respectively. Thus, a user's two hands can hold the handlebars to pivot the handlebars in two opposite directions by connection of the connecting mechanism so as to achieve an exercising or rehabilitating function.
US08469858B2 Hybrid vehicle with dual clutch transmission
A vehicle includes an engine that generates an engine torque and a motor that generates a motor torque. A transmission can receive the engine torque, the motor torque, or both. The transmission includes a first gear set and a second gear set, as well as a first clutch that at least partially engages to transfer torque to the gears in the first gear set and a second clutch that at least partially engages to transfer torque to the gears in the second gear set. A controller can control the engine torque and the motor torque to control a speed of the engine to follow a desired speed profile. The controller can also control the engagement of the first clutch and the second clutch to optimize a desired gear state to minimize system losses.
US08469854B1 Disconnectable driveline for all-wheel drive vehicle
A disconnectable driveline arrangement for an all-wheel drive vehicle includes a power take-off unit having a disconnect mechanism, a rear drive module having a torque transfer device and a limited slip clutch assembly, and a control system for controlling actuation of the disconnect mechanism, the torque transfer device and the limited slip clutch assembly.
US08469847B2 Integrated single motor hybrid transmission using rear-wheel-drive 8-speed transmission
An apparatus transmitting torque among a first torque generative device, a second torque generative device and an output member includes a first planetary gear set including respective first, second and third members, a second planetary gear set including respective first, second and third members, the respective first member of the second planetary gear set mechanically coupled to the respective first member of the first planetary gear set. The first torque generative device is mechanically coupled to the respective second member of the first planetary gear set. The second torque generative device is mechanically coupled to the respective second member of the second planetary gear set, wherein the second torque generative device includes a grounding state wherein rotation of the respective second member of the second planetary gear set is prevented and a rotational state wherein rotation of the respective second member of the second planetary gear set is not prevented.
US08469846B2 V-ribbed belt having an outer surface with improved coefficient of friction
A V-ribbed belt for a mechanical power transmission. The V-ribbed belt comprises an outer back-side surface, an inner front-side surface, and a load-carrying section disposed between the front-side and back-side surfaces. The front-side surface includes a plurality of laterally spaced longitudinally extending v-ribs. The back-side surface includes a plurality of raised features that, when running on a flat-faced, back-side pulley, form a contact patch of about 20% to about 50% of that of a traditional flat-faced belt running on a flat-faced pulley. The reduced contact patch provides increased contact pressure which in turn provides an improved effective coefficient of friction between the belt and the pulley.
US08469845B2 Chain
In a transmission chain having link plates with convex edges for sliding contact with a guide surface, the plates are asymmetric in shape so that the distance from a line connecting the centers of the connecting holes and the convex edge is greatest at a position other than at the midpoint between the connecting holes. A pivoting action of the link plates takes place as they slide over a guide surface, changing the abutment point.
US08469844B2 Engine with chain tensioner
An engine includes a case member, a guide member disposed so as to make contact with an endless transmission belt, one end section of the guide member being swingably supported on the case member and the other end section of the guide member a free end, and a chain tensioner for pressing the free end of the guide member to apply tension to the endless transmission belt. The chain tensioner includes an accommodating concave section disposed in the case member, wherein an outer side of the accommodating concave section in a direction parallel to the axis of rotation of the drive shaft has an opening section, and also includes an elastic member being accommodated in the accommodating concave section to press the guide member and a lid member covering the opening section of the accommodating concave section in the direction of the axis of rotation of the drive shaft.
US08469843B2 Expandable arrowhead or broadhead and spring element
An expandable arrowhead having a blade-carrying body with a slot that houses at least one movably mounted blade. Each blade can be pivotally mounted about a shaft. In some embodiments, the shaft is fixed with respect to the body. In other embodiments, the shaft is movably mounted with respect to the body, for example by mounting a shaft within the slot so that the shaft moves within the slot with respect to the blade-carrying body. In some embodiments of this invention, a spring element positively holds one or more blades in a closed position or a retracted position, particularly during extreme forces encountered when launching an arrow from an archery bow, such as a compound archery bow. The spring element of this invention can be used to improve blade opening capabilities of conventional blade-opening arrowheads or broadheads.
US08469841B1 Hockey puck rebounder
A hockey puck rebounder having a frame, a first and second support each extending from opposing ends of the frame, a resilient rebound member comprised of an endless-looped band and extending between the first and second supports such that the resilient rebound member is secured in a taut manner to provide a resilient spring-back force when struck by a hockey puck or ball, and various securing structures for securing the frame in a stationary manner to a playing or shooting surface. The securing structures may include a counterweight, a lower plate for sandwiching a panel, such as a piece of synthetic ice between the lower plate and the frame, and/or fasteners extended through defined openings in the frame for securing the frame to a panel or a sheet of ice.
US08469840B2 Kickoff tee and placement tee
A kickoff tee and a placement tee are disclosed. The kickoff tee has a kicking surface surrounded by a horseshoe-shaped support wall defining an open-ended kicking channel. The support wall can further include a pair of opposing protrusions that taper from the top of the support wall downwards toward the kicking surface. The placement tee exhibits a kicking surface atop a kicking platform. The kicking surface includes a kicking target than can be surrounded by a plurality of concentric support ridges. Additionally, the placement tee has a lateral surface extending from the kicking surface downward towards the ground. The lateral surface can exhibit one or more visual indicators to facilitate lining up of a place kick.
US08469838B2 Correcting golf tee
A trajectory correcting golf tee constructed with a stem for inserting into the ground and for supporting a golf ball in a fixed position above the ground. The stem is tapered so as to easily insert into the ground in a generally vertical position. The golf tee further includes a top surface with a depression to accept and retain a golf ball. The improvement including an elevated portion along one or two opposing edges of the top surface so as to control and correct a golf ball trajectory.
US08469835B2 Golf ball
An object of the present invention is to improve the abrasion-resistance of a golf ball having a polyurethane cover. Another object of the present invention is to enhance the resilience and the shot feeling thereof.The present invention provides a golf ball having a cover, said cover comprising, as a base resin, a thermoplastic polyurethane containing a polycarbonate polyol as a constitutional component, wherein the polycarbonate polyol has, as a repeating constitutional unit, a repeating unit (A) shown in a following Formula (I), and a repeating unit (B) shown in a following Formula (II) and having a different structure from that of (A), and a molar ratio of (A)/(B) is from 30/70 to 70/30. In Formula (I), R1 is a bivalent residue obtained by removing two hydroxyl groups from a diol having 4 to 6 carbon atoms. In Formula (II), R2 is a bivalent residue obtained by removing two hydroxyl groups from a diol having 4 to 6 carbon atoms.
US08469833B1 Ball directing putter attachment
A ball directing putter attachment includes a panel that has a first side, a second side, an upper edge, a lower edge, a first lateral edge and a second lateral edge. The first side is concavely arcuate from the first lateral edge to the second lateral edge. A base is attached to the second side. The base is attached to a putter face.
US08469832B2 Swing apparatus with detachable infant holding device
A swing apparatus comprises a support frame, a plurality of swing arms pivotally connected with the support frame, a mount platform connected with the swing arms, wherein the swing arms are operable to swing the mount platform relative to the support frame, and a portable infant holding device adapted to removably fasten with the mount platform. Once it is installed on the mount platform, the infant holding device can be positioned above the support frame and swing arms, in particular above the pivot links that connect the swing arms with the support frame. As a result, the swing apparatus can be used in a more versatile manner, and access to the infant holding device can be facilitated for placement and removal of the infant.
US08469829B2 Fixed constant velocity universal joint
A fixed type constant velocity universal joint includes an outer joint member including an inner surface in which a plurality of track grooves are formed, an inner joint member including an outer surface in which a plurality of track grooves are formed, a plurality of balls between the track grooves of the outer joint member and the inner joint member so as to transmit torque, and a cage having pockets for housing the balls, and being between the outer joint member and the inner joint member. At a maximum operating angle, the balls roll up to track-groove-opening-end portions of the outer joint member. Each of the track grooves of the outer joint member includes a hardened layer formed so as to extend from a track-groove deep side to the track-groove-opening-end portion, the hardened layer being thinner at the track-groove-opening-end portion compared with the other portions.
US08469826B2 Radial piston damped torsional coupling and machine using same
A damped torsional coupling is utilized to couple a drive shaft to a work shaft while permitting some relative rotation due to torsional vibrations. The coupling includes a second coupler oriented to rotate with respect to a first coupler about an axis through a continuum of negative to positive torque orientations. The first coupler defines a fluted perimeter surface with a number of flutes, distributed with radial symmetry about the axis. The second coupler a number of pistons reciprocally received in respective barrels to define a variable volume chamber fluidly connected to a damping passage. A spring biases the pistons and barrels to extend toward a position in contact with one of the flutes. The contact end may be an edge of a roller that rolls on the fluted perimeter surface in one of the flutes responsive to torques transmitted between the couplers.
US08469822B2 Reconfigurable gaming machine
A gaming system having one or more reconfigurable gaming machines is disclosed herein. Each gaming machine includes three reconfigurable video screens, wherein the reconfigurable first video screen, the second reconfigurable video screen, and the third reconfigurable video screen display a first game, information associated with the first game, casino specific features, or combinations thereof. The one or more gaming machines are reconfigurable to display a second game on the three reconfigurable video screens in response to receiving a reconfiguration command and downloading the second game from a server via a network so that the first reconfigurable video screen, the second reconfigurable video screen, and the third reconfigurable video screen display the second game, information associated with the second game, casino specific features, or combinations thereof.
US08469819B2 Game apparatus and game control method for controlling and representing magical ability and power of a player character in an action power control program
A game apparatus and game control method for controlling and representing magical ability and power of a player character, in an action power control program is provided. The game apparatus and game control method permits the accessing of an unlimited level of magical power available to the player character by affecting a control button on the input device, which then allows for a determination to be made on a proper amount of the unlimited level of magical power based upon the player character's known abilities and vitality to be used, which then in turn permits utilization of said proper amount of the unlimited level of magical power against at least one other character within the video game to obtain a desired result against said at least one other character before a detrimental effect causes a penalty to the player character.
US08469814B2 Game apparatus and computer-readable storage medium
A twist amount is calculated based on an angular velocity around a Z-axis of an input device when a player performs a shoot operation. Based on a value of a difficulty level stored in an external main memory, a minimum successful twist amount and a maximum successful twist amount are determined. As a result, the higher the difficulty level is, the narrower a successful range of the twist amount becomes. Further, the twist amount of the input device, which is obtained when the player performs the shoot operation for a first to a fourth shots, is stored in the external main memory. When the player performs the shoot operation for a fifth shot or thereafter, the twist amount of the input device at the time of the shoot operation for the fifth shot and thereafter is corrected with the use of the twist amount of the first to fourth shots.
US08469812B2 Fret and method of manufacturing frets for stringed controllers and instruments
A fret and method of making the fret are disclosed. The fret can include a body portion made of a non-conductive material, a first end, a second end, and a length defined between the first and second ends. A plurality of electrically conductive elements can be disposed along at least part of the body portion. Each element can be electrically insulated from the other conductive elements by the body portion. The method can include 1) providing a blank formed of electrically conductive material, 2) processing the blank to provide a plurality of electrically conductive elements, 3) affixing a body portion made of a non-conductive material to the plurality of electrically conductive elements, the body portion electrically insulating each element from the other conductive elements, and 4) removing material from the processed blank and affixed body portion to form a perimeter of the fret in a desired shape.
US08469811B2 Information processing apparatus and storage medium having information processing program stored thereon
An information processing apparatus calculates or obtains inclination data which changes in accordance with the inclination of an input device, from the operation data obtained from the input device. The operation data includes at least one of data on a taken image taken by the imaging means, data representing predetermined two positions in the imaging target in the taken image, data representing a direction connecting the two positions, and inclination data representing an inclination of the input device which is calculated based on the direction. The information processing apparatus replaces an object (panel, etc.) displayed on a screen with another object based on the inclination data and displays the replacement result.
US08469808B2 System and method for managing a game controller device for electronic trading
According to one embodiment, a method for electronic trading is provided. A plurality of controller signal relationships are stored, each controller signal relationship associating one or more game controller signals with a trading system command associated with the electronic trading of financial instruments via a trading platform. One or more game controller signals generated by a game controller are received and at least one of the plurality of controller signal relationships is modified based at least on the one or more received game controller signals.
US08469807B2 Game device, game control method, and information memory medium
A game device has a playing unit, a receiving unit, and a changeover unit. The playing unit plays any piece of motion image data as play-target motion image data among plural pieces of motion image data. The receiving unit receives an instruction input of specifying a position. The plural pieces of motion image data include motion image data associated with a set of a time period (a changeover time period) in a playing time of the motion image data, a position (a changeover determination position), and any piece of motion image data (changeover motion image data). The changeover unit changes over the play-target motion image data to the changeover motion image data when (a) the changeover time period includes a time point when the instruction input was received, and when (b) the changeover determination position and the position specified through the instruction input both satisfy a predetermined proximity condition.
US08469804B2 Games, gaming machines, systems and method having a horserace bonus feature
Disclosed are games, gaming machines, gaming systems and methods having a horserace bonus feature game including randomly generated icons which serve to advance one or more horses toward a finish line. In some embodiments, a progressive award associated with the winning horse is paid to a player. In other embodiments, multiple progressive awards may be paid in the event of a tie.
US08469803B2 Gaming method, server, and computer readable medium for distributing a total pool between a charity pool and a prize pool
Disclosed herein are a method and system for distributing funds associated with a game. The method receives a plurality of requests to enter the game and processes each request to issue a corresponding ticket in the game. Each ticket is associated with a donation to a selected charity and a pledge amount. The method determines a total pool of funds derived from the tickets and determines a winning ticket of the game from the plurality of tickets issued in response to the requests. The method then distributes the total pool of funds between a charity pool and a prize pool, dependent upon the donations and the pledge amount associated with the winning ticket.
US08469802B2 Enhanced game play awards and use in gaming environments
A method is shown for enhancing game play on a gaming machine. In one embodiment, the gaming machine may include a processor, a memory, and program logic stored in the memory that may be executable to play a base game in exchange for a wager. The method includes receiving a Newprom award that is not issued by the gaming machine. The method may include altering, using the processor, the base game to an enhanced base game state in response to the Newprom award. The Newprom award may be configured to add one or more base game play enhancements available to a player only by way of the Newprom award to the base game. This may alter the base game to the enhanced base game state so that the base game is played with the one or more game play enhancements.
US08469792B2 Electronic gaming method and system having variable game display timer
An electronic gaming method, system and program product for controlling the time a player has in which to play an electronic game based on the potential winnings available for the electronic game. A game field is constructed having a plurality of elements on a game display wherein each element is filled by a game symbol from a plurality of available game symbols. The game symbols for each element are automatically determined such that there is no winning combination without player interaction. A maximum value that can be obtained for a winning combination for the constructed field is determined. The field of game symbols is presented to the player on the game display. A game timer is initiated that varies with the maximum value that can be obtained for a winning combination. The player selects a field element to turn the symbol displayed into a wild symbol. The player's selection of the field element for the wild symbol location is received by the game software which determines each winning combination of symbols that is formed by such wild symbol location selection. Each winning combination of symbols on the field of game symbols is displayed to the player. A method and system are also provided for determining the total fees accrued by a game operator for plays of an electronic game during a license period, in which the per game fee is based on the denomination of play selected by the players.
US08469790B1 Wireless wagering system
Floor-agent-operated wireless barcode reader for reading the barcodes imprinted on bingo packs along with barcode labels affixed to player loyalty cards and portable and/or stationary bingo player units. The two or three barcodes read by the barcode reader are transmitted over a WiFi channel to a central file server that downloads bingo player units identified by the barcodes with the bingo packs bar-coded identification and/or contents over a local area network. In addition, the central file server tracks player spend utilizing the bar-coded player identification.
US08469788B2 Convertible in-revenue and out-of-revenue gaming system and method with a real-time streaming video feed and display
A convertible in-revenue and out-of-revenue gaming system is disclosed that includes a server connected to automatically convert operating modes and control in-revenue and out-of-revenue operation of one or more banks of gaming machines. Additionally disclosed are gaming machines with video cameras connected to provide live video feed to one or more displays, such as during tournament play when live video feed of the players and the player tournament positions may be driven in real-time to an overhead display by the server operating in a tournament controller mode.
US08469787B2 Gaming system, machine and method with a prize modifier
A system, apparatus, and method are disclosed which provide a random prize modification wherein a promotion index value is produced for a player in a wagering game. This promotion index value is then used in modifying a predetermined prize based on the wagering game outcome. In one embodiment, a particular game outcome is associated with an initial index value. The promotion index value is then produced and added to the initial index value to produce a final index value. This final index value is then used to look up an associated prize which is assigned to the player.
US08469784B1 Autonomous grain combine control system
A system for controlling a grain combine having a rotor/cylinder, a sieve, a fan, a concave, a feeder, a header, an engine, and a control system. The feeder of the grain combine is engaged and the header is lowered. A separator loss target, engine load target, and a sieve loss target are selected. Grain is harvested with the lowered header passing the grain through the engaged feeder. Separator loss, sieve loss, engine load and ground speed of the grain combine are continuously monitored during the harvesting. If the monitored separator loss exceeds the selected separator loss target, the speed of the rotor/cylinder, the concave setting, the engine load target, or a combination thereof is adjusted. If the monitored sieve loss exceeds the selected sieve loss target, the speed of the fan, the size of the sieve openings, or the engine load target is adjusted.
US08469782B1 Data center air handling unit
Described herein is an air handling unit for use in an integrated data center that provides for efficient cooling.
US08469781B2 Mine barrier survival system
A barrier survival system that isolates a safe volume within a mine or other confined structure and provides breathable air to one or more survivors within the safe volume who are awaiting rescue by generating oxygen, removing one or more toxins, carbon dioxide and carbon monoxide; and providing heat.
US08469779B1 Method for debristling animal skin
A variety of compositions and methods for removing hair from animal skin are disclosed. The methods can include heating the skin and applying force to the skin to remove hair. The methods can further include applying an adhesive comprising a wax and a resin to the skin, allowing the adhesive to solidify, and applying force to the adhesive.
US08469775B2 Conversion assemblage adaptable for use in combination with a surface modifying apparatus and method thereof
The disclosure is directed to conversion assemblages adapted for use in converting a surface modifying apparatus, such as a pole sander, whereby the conversion assemblage includes a generally rigid body assembly including first and second major surfaces opposing each other, the first major surface is adapted for receiving the supporting member, and the second major surface is attachable to a surface modifying member.
US08469767B2 Vehicle with controlled motorized movements
A toy vehicle is provided with front and rear wheelbase mechanisms. Both are movably secured to a chassis, but the front mechanism moves two front segments positioned within two channels on the chassis and the rear mechanism moves a rear segment with a rear axle pivotally secured to a lower portion of the rear segment. The segments include rotatable wheels. There is also provided a motor and a clutch. The clutch is in communication with the front and rear wheelbase mechanisms. The motor when moved in a first direction engages the clutch to direct the front wheelbase mechanism to raise and lower the front segments. The motor when moved in a second direction engages the clutch to direct the rear wheelbase mechanism to raise and lower the rear segment and rear axle.
US08469766B2 Interactive toy system
Systems and methods for interactive play are provided, including a method of interacting with an action figure. The method includes the steps of providing a base unit having a processor, providing an action figure having a memory which stores data relating to the action figure, communicating the data in the form of communication signals to the processor, and presenting an activity instruction based on the communication signals received, with the activity instruction enacting a real-life activity that the action figure can engage in.
US08469765B2 Game call apparatus having a secondary air passageway
A game call apparatus for imitating sounds of game upon receiving air exhaled by a user includes a mouthpiece, a reed assembly, and a secondary air member. Air is capable of entering and exiting the game call through the secondary air member, and the game call is capable of producing multiple types of game vocalizations, such as those of male deer.
US08469760B2 Light emitting device and method for producing same
A light emitting device 10 includes: a lead frame 12a serving as a mounting portion having a cup 13; a light emitting element 14, mounted on the bottom face 13a of the cup, for emitting light having a predetermined peak wavelength; a layer of large phosphor particles 16, adsorbed and formed on the light emitting element, for absorbing light emitted from the light emitting element and for emitting light having a longer peak wavelength than that of the light emitted from the light emitting element; small phosphor particles 18, which have a smaller particle diameter than that of the large phosphor particles, for absorbing at least one of light emitted from the large phosphor particles and light emitted from the light emitting element and for emitting light having a longer peak wavelength than that of the at least one of the light emitted from the large phosphor particles and the light emitted from the light emitting element; and a sealing member 20, in which the small phosphor particles are dispersed, for sealing the light emitting element and the layer of large phosphor particles in the cup.
US08469759B2 Method of manufacturing spark plug
In joining a composite tip to an electrode, a method is used for properly adjusting the height of radiation of a laser beam to the height of the boundary between two tips used to form the composite tip. Further, a process for joining a first tip and a second tip together by use of a laser beam includes the steps of; (a) disposing the second tip on a support; (b) obtaining, after pressing downward at least the second tip by the use of a pressing jig, a correction value for correcting the height of radiation of a laser beam; (c) correcting the height of radiation of the laser beam on the basis of the correction value; and (d) joining the first and second tips together by use of the laser beam.
US08469753B2 Pins for semiconductor device
A pin for a semiconductor device is disclosed. A connection head includes a plurality of curved protruded ribs and a plurality of recessed grooves. The curved protruded ribs and recessed grooves are alternately arranged. The curved protruded ribs radially extend from the center of the connection head. A pin stem is connected to the connection head.
US08469752B2 Electrical connector having shorting bar operation device
The present invention relates to an electrical connector having a shorting bar and an operation device for controlling the shorting bar. The connector has a housing and electrical conductive terminals disposed in the housing. One or more metal shorting bars are attached to the housing, each shorting bar electrically connects two or more terminals as a protective measure to the systems connected to these terminals before the connector is connected to a counterpart connector. The operation device is movably disposed inside the housing. During the connecting process, the operation device is pushed by the counterpart connector to move relative to the housing towards the shorting bar. Upon completion of the connecting process, a portion of the operation device is inserted between the shorting bars and the terminals whereby the shorting bar are electrically isolated from the terminals to resume the original functions of these terminals.
US08469751B2 Electrical connector and harness
A waterproof connector includes a female contact, a housing, and a retainer. The housing includes a first inner wall surface, a second inner wall surface, a first engaging part, and a lance. The female contact includes a pressed surface that is pressed by the lance, and a first engaged part that is formed to protrude in a direction away from the pressed surface. A second engaging part is formed in the housing and a second engaged part that can be engaged with the second engaging part is formed in the female contact so that a second engagement between the housing and the female contact is achieved on a side opposite to the side of a first engagement between the first engaging part and the first engaged part with respect to a central axis of the female contact.
US08469745B2 Electrical connector system
An electrical connector system may include a plurality of wafer assemblies. Each wafer assembly may include a first overmolded array of electrical contacts defining a plurality of apertures; a second overmolded array of electrical contacts configured to be assembled with the first overmolded array of electrical contacts, the second overmolded array of electrical contacts defining a plurality of apertures; and a conductive ground bracket positioned in the wafer assembly between the first overmolded array of electrical contacts and the second array of electrical contacts. The conductive ground bracket defines a first array of ridges, each ridge of the first array of ridges positioned in an aperture of the first overmolded array of electrical contacts. The conductive ground bracket defines a second array of ridges, each ridge of the second array of ridges positioned in an aperture of the second overmolded array of electrical contacts.
US08469742B2 Wire seal having a body with a projection insertable into a contact insertion passageway
A waterproof connector is provided with a connector housing and a wire seal. The connector housing includes a plurality of first contact insertion passageways. The wire seal includes a wire seal body and at least one projection. The wire seal body includes a plurality of second contact insertion passageways disposed at positions corresponding to the plurality of first contact insertion passageways and receive a plurality of contacts pressed tightly against edges of inner perimeters of the plurality of second contact insertion passageways to seal the plurality of second contact insertion passageways when the contacts are inserted through the plurality of second contact insertion passageways. The at least one projection extends from the wire seal body and is disposed along positions corresponding to any of the plurality of first contact insertion passageways. The plurality of second contact insertion passageways are insertable through the first contact insertion passageway.
US08469741B2 Stretchable conductive connector
A stretchable conductive connector. The conductive connector can include a viscoelastic support member having a variable length, and a conductor coupled to the support member. The conductor can include at least one bend to accommodate the variable length of the viscoelastic support member.
US08469737B2 Latch assembly for mounting power supply base for a process fieldbus on a DIN rail and method
A method for mounting a latch to a base, the base having an interior cavity for an electronic component, the latch configured to receive a support member for mounting the base to the support member, includes the steps of attaching a release member to the base and holding the release member in a stationary position, placing a latch against the base and forming a connection between the release member and the latch, and moving the release member and latch to a second position where the latch and release member are freely movable between latched and unlatched positions.
US08469733B2 Pluggable module for engaging with a cage mounted on a printed circuit board
A pluggable module includes a base, a cover assembled with the base to form a housing and a latching mechanism at least partially disposed within the housing. The latching mechanism includes an actuating portion and a single sliding portion which is connected with the actuating portion and disposed within the housing, the single sliding portion including a flat board and two sliding legs respectively extending from two opposite sides of the flat board, each sliding leg having a latching protrusion formed thereon and exposed outside the housing for latching with and detaching from the cage. The present invention uses a single sliding portion to replace two sliding arms thereby simplifying the manufacturing and assembling process, in turn, reducing the manufacturing and assembling cost.
US08469731B2 Connector assembly for connection under voltage
A connector includes a first connection element (2) provided with a portion of greater diameter (9) upstream to a portion of smaller diameter (10) and a second connection element (3) provided with a female contact element (14, 16) including a local narrowing of diameter (20), the narrowing being upstream to a contact piece (14) housed at the bottom of a cavity. During the connection between the two connection elements, the portion of greater diameter of the male contact element comes into contact with the local narrowing of diameter of the female contact element in the corresponding cavity, before the portion of smaller diameter of the male contact element comes into contact with the contact piece housed at the bottom of the cavity.
US08469728B1 Polarity protection for electrified grid and mating connector
A connector, an electrified grid element and the combination. First and second contacts with first and second contact portions are secured in the housing of the connector. The second contact portion is offset from a first surface of the connector a greater distance that the first contact portion. An electrified grid has a first conductor and a second conductor, with the first conductor having an opposite polarity to the second conductor. A first insulator member is positioned proximate the first conductor and a second insulator member is positioned proximate the second conductor. The first and second insulator members prevent the mating of the connector to the electrified grid unless the connector is properly oriented in the electrified grid, thereby insuring proper polarity between the connector and the electrified grid.
US08469724B1 Bus bar for power distribution on a printed circuit board
A bus bar distributes power to a plurality of electronic components supported on a printed circuit board. One embodiment of the bus bar comprises a plurality of compressible contact pads made from an electronically conductive polymer, spaced along the bus bar for contacting conductive contacts that are coupled to a power domain or individual electronic component. The pads may be secured to the bus bar and the conductive traces using an electronically conductive epoxy adhesive. Rivets may then be used to secure the bus bar to the printed circuit board and compress the pads, which conform to the printed circuit board to make a reliable electrical connection with the conductive traces. The bus bar further comprises a plurality of current sense points disposed adjacent to the pads for measuring the amount of current provided to each power domain.
US08469721B2 Customizable power utility connectors and methods and connections including same
A transverse wedge connector system for forming an electrical connection with first and second elongate electrical conductors includes an electrically conductive first connector member, an electrically conductive second connector member, an insert member, and a clamping mechanism. The first connector member includes a first body having a first channel portion and a first abutment portion. The first channel portion defines a first channel to receive the first conductor. The second connector member includes a second body having a second channel portion and a second abutment portion. The second channel portion defines a second channel to receive the second conductor. The insert member is configured to be selectively mounted in the first channel and defining an insert member channel to receive the first conductor when the insert member is mounted in the first channel. The clamping mechanism is selectively operable to displace the first and second connector members relative to one another from an open position to a closed position to clamp the first conductor between the first channel portion and the second abutment surface, and to clamp the second conductor between the second channel portion and the first abutment portion to thereby form a connection.
US08469719B2 Connector terminal for lamps
An electrical connection device for a lamp housing is disclosed. The electrical connection device allows for simple and straightforward alignment of circuit connector terminals with conductive power connection pads on a lamp circuit board within a lamp housing.
US08469711B2 System, method and apparatus for driver training of shifting
An application for a shifter simulator for driver training includes a shaft with a handle covering an upper end of the shaft. An upper plate is coupled to the shaft and is slideably interfaced to a lower plate by a plurality of linear bearings, allowing the upper plate to slide in a Y direction with respect to the lower plate. There are spring loaded Y ball detents attached to the lower plate which interface to Y detent grooves attached to the upper plate. The spring loaded Y ball detents and Y detent grooves provide a plurality of natural stopping locations similar to those of a transmission of the target vehicle. A shift arm guide is affixed to the shaft and interfaces to an H-gate. The H-gate is affixed to the lower plate and has detents such that the H-gate and shift arm guide simulate gear shifting positions.
US08469702B2 Fire and water display with integrated safety features
A system for providing a combined water and fire display is provided. More specifically, a decorative display comprises a dynamic water and fire display device where fuel/air, water, and fire are integrated. The decorative display provides for unique aesthetic qualities and an appearance wherein flames are positioned at or near the surface of a volume of water. In various embodiments, the decorative display further comprises various safety features including the ability to detect and self-regulate conditions such as the existence and/or absence of a pilot flame, an adequate amount of water, and the temperature of various portions of the system. The decorative display further contemplates the ability to operate without one or more disclosed features, such as when only a water display or only a fire display is desired.
US08469700B2 Fouling and corrosion detector for burner tips in fired equipment
A system for predicting fouling and corrosion of a combustion system in an industrial process includes a pipe, a restrictive element, and a fouling and corrosion detector. The pipe contains a fuel. The restrictive element is coupled to the pipe and the fuel passes through the restrictive element. The fouling and corrosion detector is coupled to the pipe and is adapted to detect a characteristic signature of the restrictive element and to generate an alarm if a change in the detected signature exceeds a predetermined limit relative to a baseline signature.
US08469696B2 Slide mechanism for the molding and ejection of parts molded with negatives for an injection mold
The invention relates to a slide mechanism comprising an ejector shaft (2) with a first end portion (2c) attached to a mobile ejector plate (3), a second conical end portion (2a) which ends in a protrusion (2b) coupled to a cam (6), the protrusion (2b) acting as a rotation shaft on which the cam (6) can oscillate; a wedge-shaped slide (5) with a molding portion (5d), an inclined segment (5a) between a push surface (5b) which is in contact with the part to be obtained (10) and a base segment (5c) and a sliding passage (14) which extends through the slide (5) in which at least one portion of the cam (6) slides in parallel with the negative (11a); a fixed sliding support (4) with an axial passage (4a) through which the ejector shaft (2) axially slides, and a slope (4c) on which the inclined segment (5a) of the slide (5) shifts, with a complementary inclination to that of the inclined segment (5a) of the slide.
US08469693B2 Low profile stack mold carrier
An injection molding machine can include a base, a stationary platen fixed to the base for holding a first mold section and a moving platen for holding a second mold section. The moving platen can be slidably supported on a platen slide surface fixed to the base. The injection molding machine can also include a stack mold carriage for holding a mold center section. An actuator can be coupled to the stack mold carriage for translating the stack mold carriage along the machine axis towards and away from the stationary platen, the actuator comprising a driven member coupled to a carriage connection portion. The carriage connection portion can transfer motion from the driven member to translation of the stack mold carriage. The carriage connection portion can be joined to the stack mold carriage at an elevation below the platen slide surface.
US08469682B2 Peristaltic pump with torque relief
A peristaltic pump for dispensing liquid is described and includes a front housing and a rear housing snap-fitted together to define a chamber having a recessed area and a rotor confined therein, a plurality of rollers mounted in the rotor, and a flexible tube compressed at equally spaced intervals by the plurality of rollers. The rotor undergoes a gradual increase in torque as a benefit of the recessed area, rather than an immediate high-torque load at the start of each pump cycle. Further, the pump is resistant to constant torques and vibrations caused by a machine to which it is attached so that the pump does not become loose and fall apart.
US08469679B2 Sealed type rotary compressor
An object of the present invention is to promote oil separation in a sealed container, thereby decreasing the amount of oil discharged to the outside of a compressor. The compressor comprises discharge hole provided at position facing the end surface of a rotor and through which a compressed refrigerant from first and second rotary compression elements is discharged into the sealed container; and a refrigerant flow path which is extended from a space surrounded with a coil end of a stator projecting from the end surface of the rotor to a rotary compression mechanism side to a space of an air gap between the rotor and the stator, to guide the compressed refrigerant discharged through the discharge hole to an electromotive element opposite to the rotary compression mechanism side. The outlet of this refrigerant flow path opposite to the rotary compression mechanism side faces the inner wall surface of the sealed container, and the volume of a space between the inner wall surface of the sealed container and the electromotive element is 1.5 times or more and 15 times or less that of a space between the rotary compression element and the electromotive element.
US08469678B2 Constant temperature circulator
An constant temperature circulator for maintaining a liquid at a constant temperature including a housing that encapsulates a controller, a display, a heating element, a temperature sensor, and an electric motor having an impeller. The housing includes a first port and a second port that cooperatively define a chamber that encapsulates the impeller, an aperture and an opening, such that actuation of the impeller when the electric motor is activated by the controller moves the liquid from the aperture, through the chamber and to the opening.
US08469677B1 Check valve pump with electric bypass valve
A hydraulic power unit having a power shaft that rotates a cam. The cam actuates a piston assembly that contains a plurality of pistons wherein each piston has a piston body and fluid working chamber. An electrically actuated bypass valve is fluidly connected and in communication between an outlet check valve and a fluid working chamber of each piston such that when actuated the electrically actuated bypass valve directs fluid away from the outlet port into a reservoir to be returned to an inlet port.
US08469675B2 Priming protection
Embodiments of the invention provide a pumping system for at least one aquatic application. The pumping system includes a pump, a motor coupled to the pump, and a controller in communication with the motor. The controller determines an actual power consumption of the motor and compares the actual power consumption to a reference power consumption. The controller also determines that the pump is in an unprimed condition if the actual power consumption is less than the reference power consumption and that the pump is in a primed condition if the actual power consumption is at least equal to the reference power consumption.
US08469674B2 Operation control device and method of compressor
Disclosed are an operation control device of a compressor, which can reduce motor loss by applying an AC power to a motor of the compressor without a switching operation of a control unit, and a method thereof. The operation control device of the compressor comprises: a capacitor electrically connected to a motor of the compressor and having a predetermined capacitance; a control unit connected in series to the motor of the compressor and applying an AC power to the motor of the compressor according to a control signal; and a controller detecting a load variation amount on the basis of a current and voltage applied to the motor of the compressor and controlling on/off of the control unit according to the detected load variation amount.
US08469672B2 Blade for a wind turbine rotor
Provided is a blade for a rotor of a wind turbine having a substantially horizontal rotor shaft, said rotor comprising a hub, from which the blade extends substantially radially when mounted, said blade having a chord plane extending between a leading edge and a trailing edge of said blade, a root area closest to the hub, an airfoil area furthest away from the hub, a transition area between the root area and the airfoil area, a first airfoil extending substantially along the entire airfoil area, and a second airfoil separately mounted to the blade, said second airfoil arranged at a mutual distance transverse to the chord plane and extending along the root area of the blades.
US08469671B2 Impeller
The invention relates to closed impellers (1) for centrifugal pumps used for conveying homogeneous liquids, especially in cooling systems of motor vehicles. The aim of the invention is to develop a novel design of closed impellers (1) for centrifugal pumps used for conveying homogeneous liquids, especially in coolant pumps, such that closed impellers comprising single-curved blades (3) as well as closed impellers comprising three-dimensionally curved blades (3) can be produced at a low cost while the effect of cavitation wear is minimized on the parts/subassemblies that are mounted downstream of the impeller and the hydraulic efficiency as well as the suction behavior of the respective impeller design is significantly improved. The aim is achieved by a closed impeller (1) for centrifugal pumps which is characterized in that the width of the blade channel continuously increases from the feeding point of the flow into the impeller to the discharge point of the flow from the impeller (1) from a perspective of the meridian section such that the ratio between the width (b2) in the discharge point and the width (b1) at the feeding point ranges from 1.01 to 1.2.
US08469669B2 Cover disk for a closed impeller
A cover disk (1) for a closed rotor of a radial flow machine or diagonal flow machine for defining a flow channel has a wall thickness which has a local maximum along the profile mean line of the meridional cross section of the cover disk between a first front side (2) and a second front side (3) of the cover disk. An outer surface (1.2) of the cover disk remote of the flow channel has in the area of this local maximum a convex curvature with a radius (R2.2) whose ratio (R2.2/D2) to an outer diameter (D2) of the rotor is within a range of 0.05 to 0.5 (0.05≦R2.2/D2≦0.5).
US08469668B2 Hydraulically controlled variable pitch propeller
Proposed is a redundant hydraulically controlled variable pitch propeller for an air, land or water craft, comprising at least two propeller blades (14) mounted in a propeller hub (12) for variable pitch control by means of a hydraulically powered piston assembly (18). In accordance with the invention the piston assembly (18) comprises two mechanically interconnected servo pistons (20, 22) each assigned an independent hydraulic circuit.
US08469666B1 Turbine blade tip portion with trenched cooling holes
A turbine blade with a squealer pocket formed by a tip rail extending along the pressure side and suction side of the tip. A row of diffusion trenches are spaced along the pressure side tip rail and the suction side tip rail, each trench formed by side walls and a bottom wall so that the front face and top face of the trench is open. Each trench includes side walls that increase in width in the direction of the tip crown, is connected by a metering hole to discharge cooling air into the trench, are separated from each other and are spaced from near the leading edge to near the trailing edge, and includes a curved inward surface toward the squealer pocket. Two rows of convective cooling holes are spaced adjacent to the pressure side tip rail and the suction side tip rail and open into the squealer pocket.
US08469659B2 Turbine blade cascade endwall
Provided is a turbine blade cascade endwall that is capable of suppressing a vortex generated on a suction surface of a turbine stator blade and that is capable of reducing secondary-flow loss due to this vortex. A turbine blade cascade endwall that is positioned on a tip side of a plurality of turbine stator blades arranged in a ring form is provided with a pressure gradient alleviating part that alleviates a pressure gradient generated in the blade height direction at a suction surface of the turbine stator blades due to a clearance leakage flow, leaking out of a gap between a tip of a turbine rotor blade located on the upstream side of the turbine stator blades and a tip endwall disposed facing the tip of this turbine rotor blade.
US08469656B1 Airfoil seal system for gas turbine engine
A turbine airfoil seal system of a turbine engine having a seal base with a plurality of seal strips extending therefrom for sealing gaps between rotational airfoils and adjacent stationary components. The seal strips may overlap each other and may be generally aligned with each other. The seal strips may flex during operation to further reduce the gap between the rotational airfoils and adjacent stationary components.
US08469650B2 Method of controlling pressure in a wafer transfer system
A wafer transfer system, and method of controlling pressure in the system, includes a loadport for receiving a wafer container, a housing operably connected to the loadport, a wafer transfer mechanism for transferring a wafer between the wafer container and the housing, a wafer container sensor for detecting a presence of the wafer container on the loadport, a variable speed fan disposed in a first portion of the housing, a variable exhaust unit disposed in a second portion of the housing facing the first portion, the variable exhaust unit being capable of varying an exhaust rate of air from the housing, and a controller for variably operating the variable speed fan and the variable exhaust unit in response to a signal from the wafer container sensor.
US08469642B1 Modular precision drill countersink assembly
A modular countersink assembly, comprising a drill having an exterior tapered surface, a countersink body having an interior tapered surface for mating with the exterior tapered surface of the drill, and an insert removably secured to the countersink body enables an operator to replace either the drill and/or the insert if one or the other or both become worn. The insert is positioned both axially and radially and may have a PCD cutting edge.
US08469639B2 Actuated material removal tool
Material removal tool with a translating bar having an actuation surface shaped as a cone or frustum, wherein an axial position of the cone or frustum along a length of the translating bar corresponds to a position of a push rod in operable contact with a first flexibly mounted cartridge on which a cutting insert is mounted is disclosed. The translating bar is actuated between a first and second position to place different combinations of flexibly mounted cutting inserts and fixedly mounted cutting inserts in a radially outermost position. The material removal tool optionally includes a support for the translating bar to reduce radial variation during machining operations. Various combinations of flexibly mounted cutting inserts and fixedly mounted cutting inserts are disclosed along with various methods for removing material using the disclosed material removal tool.
US08469638B2 Cutting tool and cutting insert therefor
A cutting insert for mounting on an insert holder of a cutting tool. The cutting insert has a rear surface with two protuberances. The insert holder has a base surface with two recesses. Three abutment regions are formed on the side surfaces of the two protuberances and the two recesses when the cutting insert is releasably retained in the insert holder with a retaining screw. Two further abutment regions are formed between the two holder recess lower surfaces and the two insert protuberance upper surfaces.
US08469637B2 Cutting insert having non-symmetrical back side face portion and cutting tool comprising the same
A cutting insert has an upper face and a lower face; a front side face portion and a back side face portion, the front and back side face portions connecting the upper face and the lower face; and a through-hole passing through the upper face and the lower face. A cutting edge is formed in the front side face portion, and the back side face portion is provided with a first inclined face and a second inclined face which are inclined forwardly at different angles, respectively, with respect to a plane normal to a rotational axis. The first inclined face is longer than the second inclined face so that the back side face portion has a non-symmetrical convex “V” shape.
US08469634B2 Method and system of depth triggers for marine geophysical survey cable retriever systems
Depth triggers for marine geophysical survey cable retriever systems. At least some of the illustrative embodiments are methods including causing a submerged geophysical survey cable to surface. The cause may include: moving a piston within a cylinder of a housing coupled to the geophysical survey cable, the moving of the piston responsive to pressure exerted on a face of the piston as the geophysical survey cable reaches or exceeds a predetermined depth, wherein the movement of the piston overcomes a force created by interaction between two materials, the force latches the piston in place at depths above the predetermined depth; and responsive to the piston overcoming the force that latches the piston deploying a mechanism that makes the geophysical survey cable more positively buoyant, the deploying responsive to movement of the piston.
US08469633B2 Vessel with abandoning and recovering system for pipelines, method, and use of said vessel and system
A vessel (1) for laying a pipeline (2), comprising a tower (3) which comprises a firing line (4) and is connected to the vessel by a hinge assembly (5) comprising a tower pivot axis (6), wherein: the tower is pivotable relative to the vessel about the tower pivot axis, during pipelaying the tower comprises an upper end and a lower end and the pipeline moves relative to the vessel along the firing line in a laying direction from the upper end towards the lower end, and the tower pivot axis is located at a distance D1 from said upper end as viewed in the laying direction, a system for abandoning and recovering the pipeline, wherein: the system comprises at least one line for lowering and raising a member configured to be connected to the pipeline, and the at least one line is supported by the hinge assembly and/or by the tower at a distance of at least ⅘ D1 from said upper end as viewed in the laying direction.
US08469630B2 Sensor system for construction equipment having wireless sonic sensor system
A sensor system for road construction equipment. The system includes a first conveyor for transporting material to a first auger that is positioned to receive the material. A first feeder sensor associated with the first conveyor is in over-the-air communication with a receiver to communicate the height of a material on the conveyor such that a master controller that is electrically connected to the receiver can regulate the amount of flow of material to the first conveyor.