Document Document Title
US08471262B2 Semiconductor device and fabrication method thereof
This invention provides a semiconductor device having high operation performance and high reliability. An LDD region 707 overlapping with a gate wiring is arranged in an n-channel TFT 802 forming a driving circuit, and a TFT structure highly resistant to hot carrier injection is achieved. LDD regions 717, 718, 719 and 720 not overlapping with a gate wiring are arranged in an n-channel TFT 804 forming a pixel unit. As a result, a TFT structure having a small OFF current value is achieved. In this instance, an element belonging to the Group 15 of the Periodic Table exists in a higher concentration in the LDD region 707 than in the LDD regions 717, 718, 719 and 720.
US08471257B2 Motherboard, production method of motherboard, and device substrate
The present invention provides a motherboard having panel substrates efficiently arranged thereon and a reduced wasted substrate region, a method for producing the motherboard, and a device substrate comprising the panel substrates formed on the motherboard. The motherboard of the present invention comprises a plurality of panel substrates, wherein the motherboard has a silicon thin film formed on a principal surface thereof, each of the panel substrates has a transistor forming region and a marginal region, the transistor forming region is formed by polycrystallizing the silicon thin film, the marginal region is provided on an outer edge of each of the panel substrates, and at least one of the panel substrates has the marginal region including a region with a silicon thin film which has a crystal profile different from a crystal profile of a silicon thin film in the transistor forming region.
US08471255B2 Bottom-gate thin-film transistor having a multilayered channel and method for manufacturing same
Provided is a thin film transistor, wherein the on-off ratio thereof is increased by decreasing the OFF current thereof. A bottom-gate TFT (10) is provided with a channel layer (40) obtained by forming a second silicon layer (35) on a first silicon layer (30). Since amorphous silicon regions (32), which surround multiple grains (31) contained in the first silicon layer (30), contain hydrogen in an amount sufficient to enable termination of dangling bonds, most of dangling bonds in the amorphous silicon region (32) are terminated by hydrogen. For this reason, it becomes less likely to have defect levels formed in the amorphous silicon regions (32), and an OFF current that flows through defect levels is therefore decreased. A high number of the grains (31) are retained in the first silicon layer (30), and cause a large ON current to flow. Consequently, the on-off ratio of the TFT (10) is increased.
US08471253B2 Crosslinked hybrid gate dielectric materials and electronic devices incorporating same
Disclosed are thin film transistor devices incorporating a crosslinked inorganic-organic hybrid blend material as the gate dielectric. The blend material, obtained by thermally curing a mixture of an inorganic oxide precursor sol and an organosilane crosslinker at relatively low temperatures, can afford a high gate capacitance, a low leakage current density, and a smooth surface, and can be used to enable satisfactory transistor device performance at low operating voltages.
US08471252B2 Semiconductor device and method for manufacturing the same
An embodiment is to include a staggered (top gate structure) thin film transistor in which an oxide semiconductor film containing In, Ga, and Zn is used as a semiconductor layer and a buffer layer is provided between the semiconductor layer and a source and drain electrode layers. A metal oxide layer having higher carrier concentration than the semiconductor layer is provided intentionally as the buffer layer between the source and drain electrode layers and the semiconductor layer, whereby an ohmic contact is formed.
US08471251B2 Electroactive materials
There is provided an electroactive material having Formula I wherein: Q is the same or different at each occurrence and can be O, S, Se, Te, NR, SO, SO2, or SiR3; R is the same or different at each occurrence and can be hydrogen, alkyl, aryl, alkenyl, or alkynyl; R1 through R8 are the same or different and can be hydrogen, alkyl, aryl, halogen, hydroxyl, aryloxy, alkoxy, alkenyl, alkynyl, amino, alkylthio, phosphino, silyl, —COR, —COOR, —PO3R2, —OPO3R2, or CN.
US08471248B2 Electroluminiscent metal complexes with dibenzo[f,h] quinoxalines
This invention relates to electroluminescent metal complexes of the formula (I), or (II), a process for their preparation, electronic devices comprising the metal complexes and their use in electronic devices, especially organic light emitting diodes (OLEDs), as oxygen sensitive indicators, as phosphorescent indicators in bioassays, and as catalysts.
US08471244B2 Method and system for providing a metal oxide semiconductor device having a drift enhanced channel
A method and system for providing a metal oxide semiconductor (MOS) device are described. The method and system include providing a source, a drain, and a channel residing between the source and the drain. At least a portion of the channel includes an alloy layer including an impurity having a graded concentration. The method and system also include providing a gate dielectric and a gate electrode. At least a portion of the gate dielectric resides above the alloy layer. The gate dielectric resides between the alloy layer and the gate electrode.
US08471242B2 Light emitting device, light emitting device package and lighting system
Disclosed is a light emitting device, including: a substrate, a light emitting structure provided on the substrate, which includes a first conductive semiconductor layer, an active layer and a second conductive semiconductor layer laminated in sequential order, a transmissive electrode layer arranged on the light emitting structure, an electrode provided on the light emitting structure. Here, the electrode includes a pad electrode and a finger electrode, and an insertion element is placed between the finger electrode and the second conductive semiconductor layer, wherein the insertion element is formed such that at least one region thereof overlaps with the finger electrode in a vertical direction. Since the insertion element is formed under the finger electrode, it is possible to prevent light emitted by the active layer from being absorbed by the finger electrode. Accordingly, luminous efficacy of the light emitting device may be further enhanced.
US08471230B2 Waveguide substrates and optical systems and methods of use thereof
This invention provides substrates for use in various applications, including single-molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided.
US08471229B2 System for radiation sterilization of medical devices
Methods and systems for selection radiation exposure in sterilization of medical devices are disclosed.
US08471228B2 Fast scanning of a target region
The invention concerns a method for irradiating a target with a beam approaching target points, involving the following steps: Measuring at least one of the parameters relating to the position of the beam and the intensity of the beam, changing the beam as a function of the at least one measured parameter, particularly as a function of a variance relating to the at least one measured parameter. The method is characterized in that the at least one measured parameter is measured at the most once per target point. Furthermore, the invention concerns a device for irradiating a target in accordance with the invention-based method and a control system for controlling such a device.
US08471225B2 Charged particle beam writing method and apparatus therefor
A charged particle beam writing method includes inputting layout information of a plurality of chips on which pattern formation is to be achieved, setting, using the layout information, a plurality of writing groups each being composed of at least one of the plurality of chips and each having writing conditions differing from each other, setting a frame which encloses a whole of all chip regions in all the plurality of writing groups, virtually dividing the frame into a plurality of stripe regions in a predetermined direction while keeping chips of writing groups differing from each other intermingled, setting an order of each of the plurality of stripe regions such that a reference position of the each of the plurality of stripe regions is located in order in the predetermined direction, and writing a pattern in the each of the plurality of stripe regions onto a target workpiece according to the order which has been set, by using a charged particle beam.
US08471223B2 Apparatus and method for sample preparation
A sample stage for processing a sample in an ion beam etching apparatus has positioning arrangements each having a receiving apparatus and a mask, a sample being mountable in the receiving apparatus with reference to an ion beam and positionable relative to the mask. The sample stage includes a mechanism that enables a switchover between respective positioning arrangements so a selected positioning arrangement is respectively orientable toward the ion beam. The sample in the selected positioning arrangement is exposed to the ion beam while the remaining positioning arrangements face away from the ion beam. The positioning arrangements are arranged in one common vessel. A method for sequential preparation of at least two samples in an ion beam etching unit using the sample stage is also disclosed.
US08471222B2 Radiotherapy apparatus control method and radiotherapy apparatus control apparatus
A radiotherapy apparatus control method according to the present invention includes: a step S6 of calculating rotational and first translational correction amounts based on a position and orientation of a first region represented by a radioscopic image of a subject; and a step S9 of calculating a second translational correction amount based on a position and orientation of the second region represented by the radioscopic image and the rotational correction amount; and a step S10 of driving a couch so that it rotates by the rotational correction amount and translates by the second translational correction amount. The first region is larger than the second region. According to such a method, the second region can be arranged in a predetermined position at higher accuracy compared with a case where the position of the couch is adjusted by using the position and orientation of only one of the first and second regions.
US08471215B1 Integrated circuit sample preparation for alpha emission measurements
Test samples for use in conducting integrated circuit alpha particle emissions testing, processes for preparing test samples for use in conducting integrated circuit alpha particle emissions testing, and processes for conducting integrated circuit alpha particle emissions testing using the test samples, are described. The approach takes into account the effects of the relative physical positions of the respective components within a final integrated circuit package, and takes into account the effect of contamination of individual components or of the integrated circuit package as a whole due to conditions and/or processes performed during the production process. The described approach relates to test sample preparation and integrated circuit alpha particle emissions testing for integrated circuits in which the alpha particle emission levels are extremely low, i.e., in the ultra low alpha region, for example, alpha particle emissions less than 0.002 cph/cm2.
US08471214B2 Method for processing 3D distribution image of radiation source and system using the same
A system for processing three dimensional (3D) distribution image of a radiation source and a processing method using the same are provided. The system includes an image measuring unit comprising a plurality of position sensitive detectors to measure the radiation source, a signal amplifying unit which receives signals from the image measuring unit and amplifies the received signals into an electric signal, a mode selecting unit that receives the electric signal and selects a detection mode and outputs a corresponding mode signal, a data storage unit which stores the signals as a series of items, a data converting unit which converts the data stored at the data storage unit into interactive data, an image reconstructing unit which reconstructs the converted data into the 3D distribution image, and a display unit which displays the 3D distribution image received from the reconstructing unit.
US08471212B2 Radiography device
In this radiography device, the radiation conversion panel side of a scintillator is formed in a convex shape towards the radiation conversion panel, the end portions of columnar crystals are formed at said side, and the end portions of the columnar crystals can contact the radiation conversion panel.
US08471211B2 Two-dimensional position map correcting method, and radiation detecting apparatus
A radiation detecting apparatus of this invention includes an arithmetic processing device which carries out arithmetic processes for drawing boundaries based on peaks of signal strengths and separating respective positions by the boundaries, and for determining, by using spatial periodicity of the peaks, the number of peaks having failed to be separated, with a plurality of peaks connecting to each other. If the separation fails with a plurality of peaks connecting to each other, the number of peaks in error is determined using spatial periodicity of the peaks. Thus, by using spatial periodicity of the peaks, the number of peaks in error can be determined and boundaries can be set easily. As a result, incident positions can also be discriminated easily, and detecting positions of radiation can be determined easily.
US08471210B2 Radiation imaging method with individual signal resolution
An imaging method and apparatus are provided. The method includes collecting detector output data from a radiation detector positioned near a subject provided with a radio-active tracer The method further includes resolving individual signals in the detector output data by determining a signal form of signals present in the data, and making parameter estimates of one or more parameters of the signal. The one or more parameters include at least a signal temporal position. The method further includes determining the energy of each of the signals from at least the signal form and the parameter estimates.
US08471209B2 Method for maintenance of an array of bolometer-type detectors
A method for maintenance of an array of bolometer-type detectors comprises heating of certain detectors to a threshold temperature. The heating is performed by supplying resistive detection elements with electric currents, and the threshold temperature is determined for each detector as a function of a measurement made previously on said detector. Such method makes it possible to eliminate persistent images caused by radiation overexposure, or by damage to the thermoelectric properties of certain pixels appearing during the manufacture or ageing thereof. The method does not require the use of an oven or Peltier element, thus avoiding the risk for such heating component to damage irreversibly the reading and CMOS addressing circuits on which the detectors are hybridised or deposited.
US08471206B1 Infrared detector vacuum test systems and methods
Systems and methods are directed to determining the vacuum integrity within a vacuum package assembly containing an infrared detector, such as within an infrared imaging device. For example for an embodiment, a method of performing a vacuum pressure test on a vacuum package includes changing a first parameter value associated with an infrared detector within the vacuum package to vary a temperature of the infrared detector; measuring a second parameter value associated with the infrared detector based on the changing of the first parameter value; comparing the second parameter value to a threshold value; and determining a vacuum pressure condition of the vacuum package based on the comparing of the second parameter value to the threshold value.
US08471198B2 Mass spectrometer sampling cone with coating
A mass spectrometer includes an ion source, which includes a coating or surface formed of a metallic carbide, a metallic boride, a ceramic or DLC, or an ion-implanted transition metal.
US08471197B2 Pulsed neutron based monitoring of CO2 in enhanced recovery and sequestration projects
A method for estimating a concentration of carbon dioxide (CO2) in a formation penetrated by a borehole, the method includes: conveying a carrier through the borehole; irradiating the formation with neutrons from a neutron source disposed at the carrier; detecting photons from the formation resulting from the irradiating; and estimating the concentration of CO2 from data acquired from the detecting.
US08471194B2 Rotary encoder for diagnosing problems with rotary equipment
A novel method for diagnosing problems with a valve actuator or other rotary equipment. Frequency analysis is performed upon speed, position, torque, thrust, or vibration data. Speed or position data may be provided by a rotary encoder.
US08471183B2 Induction heating apparatus
An induction heating apparatus includes a current supply unit configured to supply a high-frequency current to a coil for inductively heating a conductive heating element based on a direct current obtained by rectifying AC power supplied from an AC power supply, a driving unit configured to output a drive pulse for supplying the high-frequency current from the current supply unit, a control unit configured to control a frequency of a drive pulse output by the driving unit, and a power limiting unit configured to limit an operation of the driving unit when input power determined based on an input voltage of the AC power supply and an input current to the current supply unit exceeds a predetermined value.
US08471181B2 Heating device for wall, ceiling or floor coverings
The invention relates to a heating device and in particular to an element of a floor heating device. Known floor heating devices comprise heating means which are arranged underneath floor coverings, for example, below stone plates, tiles, parquet elements or laminated panels. Those heating means can be made of electrically heatable films which are arranged close to the surface of a covering in order to directly heat the room.
US08471176B2 Laser machine for examination, planning and marking raw diamond
Because of extreme hardness, diamonds have a number of important industrial applications. Generally experts work on it. Experts do marking after examining each rough diamond to decide how it should be cut to yield the greatest value. But in this process, there can be lots of wastage as it is only an image of the stone in the mind of the person. The present invention comprises Laser planner which scans each and every point of diamond by rotating it 360° and thus gives individual coordinate of that diamond. It shows us the wire frame image on the computer monitor. is a machine to scan the stone and to plan and mark for the best-fit diamond from that stone. All the data of the diamond is stored in the computer. It is material saving, time saving, mass processing increase in productivity.
US08471172B2 Elimination of short circuits between conductors by laser ablation
A method of selectively eliminating electrical shorts and other electrical defects from specific layers of a multilayer electronic device without damaging underlying layers. The method is based on a combination of an automated detection of the defects and selective laser ablation patterning (SLAP).
US08471166B1 Double break vacuum interrupter
A double break vacuum interrupter includes a first contact system with an annular stationary contact, which is engaged by a primary moving contact with the moving contact rod extending through the primary moving contact and through the opening of the annular stationary contact. A second contact system includes a secondary moving contact disposed on an end of the moving contact rod, which engages and operates a floating contact on the same axis. Both contact systems are enclosed in a sealed envelope. A mechanical adjustment system is provided for the floating contact, which controls its range of motion. The mechanical adjustment system allows the first and second contact systems to engage at approximately the same time. A system of capacitors and resistors is provided to balance the voltage between the first and second contact systems to provide more efficient interruption of the electric current.
US08471165B2 Device and method for recognizing characteristic features of empty containers
A device for recognizing characteristic features of an empty container having at least one flat support element on which the empty container can be placed with at least one lateral surface of said container on the contact surface of the support element, having a carrier to carry the empty container and having at least one optical sensor to optically scan the empty container, wherein the carrier is formed by the at least one support element, the at least one support element is carried rotatably about an essentially horizontal drive shaft, the empty container can be brought from an input position, in which the empty container is placed on the at least one support element, to a different location on the support arm and, after being scanned can be transferred to a downstream functional module.
US08471163B2 Auto transfer switch including terminal cover
Provided is a cover for protecting an upper end of a normal power terminal and an upper end of an emergency power terminal of an auto transfer switch. In this case, terminal covers are formed on the upper ends of the terminals to protect the terminals, thereby preventing operators from being hurt by electric shock.
US08471160B1 Inline conduit switch
An inline conduit switch includes a body having an anchor fitting adapted for mounting to a support and a conduit fitting adapted for mounting a control cable thereto. The conduit fitting is at least partially received in a bore of the anchor fitting for relative axial movement between a first configuration to which the body is normally biased and a second, compressed configuration. First and second electrical contacts are operatively carried by the anchor fitting and the conduit fitting, and are brought into electrically conductive engagement in the second configuration. The inline conduit switch operates to create electrical contact when a control cable is placed in tension, thereby axially shifting the conduit fitting relative to the anchor fitting.
US08471154B1 Stackable variable height via package and method
A stackable variable height via package includes a substrate having a first surface and terminals thereon. The terminals include a first terminal and a second terminal. Vias are on the terminals, the vias including a first via on the first terminal and a second via on the second terminal. The first via has a height from the first surface of the substrate less than a height of the second via from the first surface of the substrate. The package further includes a package body and via apertures in the package body to expose the vias. Forming the stackable variable height via package with variable height vias readily accommodate stacking of additional packages having different types of terminals, e.g., LGA and BGA type packages, as well as variable degrees of warpage on the stackable variable height via package. Further, the vias are formed with a minimum pitch.
US08471151B2 Layout method for bridging electrode capable of shielding bright spot and structure of the bridging electrode
A layout method for a bridging electrode capable of shielding a bright spot includes the steps of: providing a substrate; forming a transparent electroconductive layer, having neighboring pattern blocks, on the substrate; forming an alignment film layer, having bridging grooves for crossing between the pattern blocks, over the substrate; forming an electroconductive layer, having wires respectively correspondingly disposed over the bridging grooves, over the substrate; forming an electroconductive correspondence layer on one side of the electroconductive layer to shield the wires; and forming a protection layer over the substrate to enhance optical transmission and protect the substrate, the transparent electroconductive layer, the alignment film layer and the electroconductive layer. Meanwhile, the invention also provides a structure of the bridging electrode capable of shielding the bright spot and corresponding to the layout method.
US08471147B2 Cover for electronic device
A cover includes an upper cover, a lower cover, a fixing member fixed to the lower cover, and a sliding member positioned between the lower cover and the fixing member. The lower cover defines a notch. The sliding member includes at least one latching portion and a toggle that is slidably received in the notch. The upper cover defines at least one opening. The at least one latching portion is slidably received in the at least one opening correspondingly to connect the upper cover to the lower cover.
US08471143B2 Photoelectric conversion element and solar cell
Provided is a photoelectric conversion element containing a pair of opposite electrodes having therebetween: a semiconductor layer containing a sensitizing dye which is supported by a semiconductor; and a charge transport layer, wherein the sensitizing dye is a compound represented by Formula (1),
US08471141B2 Structures for low cost, reliable solar roofing
Improved photovoltaic devices, and more specifically, improved building integrated photovoltaic devices are described herein. In one embodiment, the photovoltaic roofing structure may be comprised of a roofing tile having a top surface, a bottom surface, and a recessed portion; a photovoltaic module sized to fit within the recessed portion of the roofing structure.
US08471140B2 Porous silica precursor composition and method for preparing the precursor composition, porous silica film and method for preparing the porous silica film, semiconductor element, apparatus for displaying an image, as well as liquid crystal display
A porous silica precursor composition is herein provided and the precursor composition comprises an organic silane represented by the following chemical formula 1: R1m(R2—O)4-mSi (in the formula, R1 and R2 may be the same or different and each represent an alkyl group, and m is an integer ranging from 0 to 3); water; an alcohol; and a quaternary ammonium compound represented by the following chemical formula 2: R3N(R4)3X (in the formula, R3 and R4 may be the same or different and each represent an alkyl group and X represents a halogen atom). The composition is prepared by a method comprising the step of blending the foregoing components. The porous silica precursor composition is coated on a substrate and then fired to thus form a porous silica film. Also disclosed herein include a semiconductor element, an apparatus for displaying an image and a liquid crystal display, each having the foregoing porous silica film.
US08471139B2 Thermoelectric conversion module and method for manufacturing thermoelectric conversion module
A thermoelectric conversion module which has a P-type thermoelectric conversion material and an N-type thermoelectric conversion material electrically connected to each other. The P-type thermoelectric conversion material and the N-type thermoelectric conversion material are joined with insulating material particles (ceramic spherical particles) interposed therebetween, so as not to be electrically connected to each other. The insulating material particles are joined to the P-type thermoelectric conversion material with a first adhesive material interposed therebetween and to the N-type thermoelectric conversion material with a second adhesive material interposed therebetween, and the P-type thermoelectric conversion material and the N-type thermoelectric conversion material are electrically connected to each other in a region other than the region in which the thermoelectric conversion materials are joined with the first and second adhesive material and the insulating material particles interposed therebetween.
US08471138B2 Musical instrument with one sided thin film capacitive touch sensors
Touch sensitive musical instruments are described herein including embodiments having: one-sided capacitive touch sensors with conductive ground planes, one-sided capacitive touch sensors with air gaps, one-sided capacitive touch sensors with separating material, and/or one-sided capacitive touch sensors including a combination of conductive ground planes, air gaps, and/or separating material. Embodiments of touch sensitive musical instruments simulating string instruments such as guitars are described.
US08471137B2 Pickup system with a cartridge
The present invention is a pickup system including a transducer, a mount, and a cartridge for modifying perceived sound from a musical instrument. The transducer includes a housing, a magnet and an electric signal carrier. The mount attaches the transducer to the instrument. The cartridge includes a container and attachment device, which positions the container in proximity to the transducer. The attachment device engages the container with the transducer so as to affect the electric signal created by the instrument. The cartridges and container can be either integral or interchangeable to vary resonance materials to the transducer. The container may be filled with another material, including ferromagnetic fluid for an induced magnet effect upon the perceived sound from the transducer.
US08471133B1 Quick-release cymbal felt locating device
A quick-release cymbal felt locating device includes a base internally defining a cavity having a front opening, and provided with a first insert hole vertically extended through the cavity and a second insert hole horizontally extended through the cavity; a movable clamping element extending into the cavity via the front opening thereof, and provided with a first communicating hole corresponding to the first insert hole and a second communicating hole corresponding to the second insert hole; and a safety pin transversely extended through the second insert hole and the second communicating hole for restricting or allowing displacement of the movable clamping element relative to the safety pin and the cavity. The first communicating hole and the first insert hole together form a clamping mechanism, with which a user can quickly assemble or disassemble the quick-release cymbal felt locating device to or from a cymbal pole.
US08471132B1 Method for measuring intensity distribution of light
A method for measuring intensity distribution of light is disclosed. The method includes the steps of manufacturing a superaligned carbon nanotube array arranged on a substrate; irradiating a top surface of the superaligned carbon nanotube array with a light source and changing the morphology of the top surface of the superaligned carbon nanotube array; and obtaining an intensity distribution of the light source by analyzing the morphology of the top surface of the superaligned carbon nanotube array.
US08471131B1 Maize variety hybrid X08A157
A novel maize variety designated X08A157 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X08A157 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X08A157 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X08A157, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X08A157. This invention further relates to methods for producing maize varieties derived from maize variety X08A157.
US08471130B2 Plants and seeds of hybrid corn variety CH110846
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH110846. The invention thus relates to the plants, seeds and tissue cultures of the variety CH110846, and to methods for producing a corn plant produced by crossing a corn plant of variety CH110846 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH110846.
US08471129B2 Plants and seeds of hybrid corn variety CH290586
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH290586. The invention thus relates to the plants, seeds and tissue cultures of the variety CH290586, and to methods for producing a corn plant produced by crossing a corn plant of variety CH290586 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH290586.
US08471121B2 Plants and seeds of hybrid corn variety CH781092
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH781092. The invention thus relates to the plants, seeds and tissue cultures of the variety CH781092, and to methods for producing a corn plant produced by crossing a corn plant of variety CH781092 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH781092.
US08471120B2 Plants and seeds of hybrid corn variety CH419384
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH419384. The invention thus relates to the plants, seeds and tissue cultures of the variety CH419384, and to methods for producing a corn plant produced by crossing a corn plant of variety CH419384 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH419384.
US08471119B2 Plants and seeds of hybrid corn variety CH667265
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH667265. The invention thus relates to the plants, seeds and tissue cultures of the variety CH667265, and to methods for producing a corn plant produced by crossing a corn plant of variety CH667265 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH667265.
US08471118B2 Plants and seeds of hybrid corn variety CH020602
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH020602. The invention thus relates to the plants, seeds and tissue cultures of the variety CH020602, and to methods for producing a corn plant produced by crossing a corn plant of variety CH020602 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH020602.
US08471113B2 Pepper hybrid PS09954859
The invention provides seed and plants of pepper hybrid PS09954859 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of pepper hybrid PS09954859 and the parent lines thereof, and to methods for producing a pepper plant produced by crossing such plants with themselves or with another pepper plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the fruit and gametes of such plants.
US08471111B1 Soybean cultivar 17164777
A soybean cultivar designated 17164777 is disclosed. The invention relates to the seeds of soybean cultivar 17164777, to the plants of soybean cultivar 17164777, to the plant parts of soybean cultivar 17164777, and to methods for producing progeny of soybean cultivar 17164777. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 17164777. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 17164777, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 17164777 with another soybean cultivar.
US08471108B2 Soybean variety A1023999
The invention relates to the soybean variety designated A1023999. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1023999. Also provided by the invention are tissue cultures of the soybean variety A1023999 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1023999 with itself or another soybean variety and plants produced by such methods.
US08471106B2 Lettuce cultivar danielle
A lettuce cultivar, designated Danielle, is disclosed. The invention relates to the seeds of lettuce cultivar Danielle, to the plants of lettuce cultivar Danielle and to methods for producing a lettuce plant by crossing the cultivar Danielle with itself or another lettuce cultivar. The invention further relates to methods for producing a lettuce plant containing in its genetic material one or more transgenes and to the transgenic lettuce plants and plant parts produced by those methods. This invention also relates to lettuce cultivars or breeding cultivars and plant parts derived from lettuce cultivar Danielle, to methods for producing other lettuce cultivars, lines or plant parts derived from lettuce cultivar Danielle and to the lettuce plants, varieties, and their parts derived from the use of those methods. The invention further relates to hybrid lettuce seeds, plants, and plant parts produced by crossing cultivar Danielle with another lettuce cultivar.
US08471105B2 Lettuce cultivar tenaya
A lettuce cultivar, designated ‘Tenaya’, is disclosed. The invention relates to the seeds of lettuce cultivar ‘Tenaya’, to the plants of lettuce cultivar ‘Tenaya’ and to methods for producing a lettuce plant by crossing the cultivar ‘Tenaya’ with itself or another lettuce cultivar. The invention further relates to methods for producing a lettuce plant containing in its genetic material one or more transgenes and to the transgenic lettuce plants and plant parts produced by those methods. This invention also relates to lettuce cultivars or breeding cultivars and plant parts derived from lettuce cultivar ‘Tenaya’, to methods for producing other lettuce cultivars, lines or plant parts derived from lettuce cultivar ‘Tenaya’ and to the lettuce plants, varieties, and their parts derived from the use of those methods. The invention further relates to hybrid lettuce seeds, plants, and plant parts produced by crossing cultivar ‘Tenaya’ with another lettuce cultivar.
US08471102B2 Compositions and methods for the modification of gene expression
Novel isolated plant polynucleotide promoter sequences are provided, together with genetic constructs comprising such polynucleotides. Methods for using such constructs in modulating the transcription of DNA sequences of interest are also disclosed, together with transgenic plants comprising such constructs.
US08471099B2 Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants with increased nitrogen use efficiency. The present invention further relates to nucleotide sequences and the use of those nucleotide sequences in the genetic-engineering of plants to display enhanced nitrogen assimilatory and utilization capacities, grow larger, more efficiently or rapidly, and/or have enriched nitrogen contents in vegetative and/or reproductive plant parts and/or increased biomass. More particularly, this invention relates to producing transgenic plants engineered to have altered expression of key components in the nitrogen assimilation and utilization pathways. The engineered plants may be productively cultivated under conditions of low nitrogen fertilizer input or in nitrogen poor soils. Alternatively, the engineered plants may be used to achieve faster growing or maturing crops, higher crop yields and/or more nutritious products under ideal cultivation conditions.
US08471098B1 Maize variety hybrid X95B339
A novel maize variety designated X95B339 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X95B339 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X95B339 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X95B339, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X95B339. This invention further relates to methods for producing maize varieties derived from maize variety X95B339.
US08471096B1 Maize variety inbred PH17T7
A novel maize variety designated PH17T7 and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH17T7 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH17T7 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH17T7 or a locus conversion of PH17T7 with another maize variety.
US08471091B1 Maize variety hybrid X8F942
A novel maize variety designated X8F942 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X8F942 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X8F942 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X8F942, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X8F942. This invention further relates to methods for producing maize varieties derived from maize variety X8F942.
US08471089B2 Process and plant for converting hazardous waste containing chromium VI into non-hazardous waste
The instant invention relates to a process and plant for the transformation of dangerous wastes containing chromium six as contaminant into non dangerous wastes that can be stored without special care and will be degraded in the environment without time limit. The process basically consists of milling, extracting chromium six in liquid phase and under controlled conditions of stirring, time and temperature, proceeding then, through reduction, to transform the chromium six in chromium three and then precipitating as chromium trioxide, through gasification. The solid resulting from the transformation process can be used as raw material for the manufacturing of firebricks or eventually for the manufacturing of bricks used in the building industry through a process not included in the instant description.
US08471087B2 Process that utilizes combined distillation and membrane separation in the separation of an acidic contaminant from a light hydrocarbon gas stream
Disclosed is a process for separating an acidic contaminant and light hydrocarbon of a light hydrocarbon feed having a large contaminating acidic contaminant content. Among other features, the process uses a combination of distillation and membrane separation arranged in a unique way to yield a high-purity light hydrocarbon product and a high-purity acidic contaminant product.
US08471085B2 Oligomerization catalyst system and process for oligomerizing olefins
Among other things, this disclosure provides an olefin oligomerization system and process, the system comprising: a) a transition metal compound; b) a pyrrole compound having a hydrogen atom on at the 5-position or the 2- and 5-position of a pyrrole compound and having a bulky substituent located on each carbon atom adjacent to the carbon atom bearing a hydrogen atom at the 5-position or the 2- and 5-position of a pyrrole compound. These catalyst system have significantly improved productivities, selectivities to 1-hexene, and provides higher purity 1-hexene within the C6 fraction than catalyst systems using 2,4-dimethyl pyrrole.
US08471084B2 Process for increasing weight of olefins
The process converts FCC olefins to heavier compounds. The heavier compounds are more easily separated from the unconverted paraffins. The heavier compounds can be recycled to an FCC unit or delivered to a separate FCC unit. Suitable conversion zones are oligomerization and aromatic alkylation zones.
US08471081B2 Production of diesel fuel from crude tall oil
A process has been developed for producing diesel fuel from crude tall oil. The process involves treating a renewable feedstock by hydrogenating and deoxygenating to provide a diesel boiling range fuel hydrocarbon product. If desired, the hydrocarbon product can be isomerized to improve cold flow properties. A portion of the hydrocarbon product is recycled to the treatment zone to increase the hydrogen solubility of the reaction mixture.
US08471078B2 Process for the hydrogenation of pentafluoropropene
A method of providing a blend of tetra- and/or pentafluoroalkanes comprising hydrogenating a pentafluoropropene.
US08471077B2 Process and apparatus for efficient recovery of dichlorohydrins
A process and apparatus is disclosed for recovering dichlorohydrins from a hydrochlorination reactor effluent stream comprising dichlorohydrins, one or more compounds selected from esters of dichlorohydrins, monochlorohydrins and/or esters thereof, and multihydroxylated-aliphatic hydrocarbon compounds and/or esters thereof, and optionally one or more substances comprising water, chlorinating agents, catalysts and/or esters of catalysts. The reactor effluent stream is distilled to produce a dichlorohydrin-rich vapor phase effluent stream. The dichlorohydrin-rich vapor phase effluent stream is cooled and condensed in two unit operations conducted at two different temperatures and a portion of the liquid phase effluent stream produced by the first unit operation is recycled to the distillation step for reflux. Product streams produced by the process and apparatus are suitable for further processing in a further unit operation, such as dehydrochlorination. Advantages include recovery of high purity dichlorohydrins, more efficient recovery of dichlorohydrins, and reduced capital investment in the recovery equipment.
US08471073B2 Estrogenic compounds, process for their production and pharmaceutical uses thereof
The present invention provides new estrogenic compounds of the general formula in which the substituents have the meanings that are explained in more detail in the description, and pharmaceutical compositions containing them. The compounds of the invention are useful, for example, in hormone replacement therapies (HRT/ERT) and as contraceptives and estrogenic hormone therapies. Also provided is a process for synthesizing the compounds of the invention.
US08471071B2 Silver catalyst for formaldehyde preparation
The present invention relates to a process for producing coated silver catalysts. The invention further addresses the silver catalysts themselves and the advantageous use thereof in formaldehyde synthesis.
US08471070B2 Method of converting alcohols in the presence of a catalyst of pretreated zinc oxide type
The method for catalytic conversion of alcohols according to the present invention using a zinc oxide catalyst comprises a thermal pretreatment stage in an inert and/or reducing atmosphere at a temperature of at least 100° C., prior to the reaction stage.
US08471067B2 Chiral phosphorus compounds
A process for the stereoselective preparation of a P-chiral four-co-ordinated phosphorus compound, the process comprising reacting a first reactant selected from the group consisting of a chiral alcohol, chiral amine or chiral thiol, with a second reactant comprising a P-chiral three-co-ordinated phosphorus compound, in the presence of an electrophile.
US08471066B2 Slurry process for phosphoromonochloridite synthesis
A process for preparation of a phosphoromonochloridite in high yield, by contacting phosphorus trichloride (PCl3) with an aromatic diol, such as 2,2′-biphenol, in a slurry, which contains a portion of the aromatic diol in solid form and contains a solution phase containing the remaining portion of the aromatic diol and an organic solvent, under reaction conditions sufficient to produce the phosphoromonochloridite. The slurry comprises less than 5 mole percent of a nitrogen base, calculated on total moles of the aromatic diol, and the organic solvent is selected for its low hydrogen chloride solubility.
US08471057B2 Sitagliptin intermediates, preparation methods and uses thereof
The present invention relates to Sitagliptin intermediate and preparation method and use thereof. The method comprises reacting compound of formula (II) and trifluorobromobenzene with a Grignard reagent by a Grignard reaction to obtain a compound of formula (I). Compound of formula (I) is a new intermediate compound for the synthesis of Sitagliptin. Compound of formula (I) can be easily used for preparing another important intermediate compound of formula (V) for the synthesis of Sitagliptin. The structures of the compounds mentioned above are as the following:
US08471055B2 Photo-crosslinkable liquid crystal monomers with optical activity
The present invention relates to photo-crosslinkable liquid crystal monomers with optical activity. The liquid crystal monomers contains one chiral center with an acrylate group or terminal diacrylate groups, and terminal dibenzene rings are introduced in order to extend its hard segment for the purpose of getting a wider liquid crystalline phase. By introducing the liquid crystal monomers, the room temperature nematic liquid crystal or the cholesteric liquid crystal may have a better mutual solubility and a wider, steadier structure of liquid crystal. The liquid crystal monomers have the following formula structure:
US08471051B2 C-H bond amination and olefin aziridination with β-diketiminato copper catalysts
One aspect of the present invention relates to a method for the transition metal (e.g., Cu(I)) mediated amidation of C—H bonds using electron-rich aliphatic azides. In certain embodiments, the methods are useful for the C—H insertion of nitrenes generated and stabilized by a β-diketiminato metal catalyst. In certain embodiments, said nitrenes are generated from organoazides, or by oxidation of the corresponding amine. Another aspect of the present invention relates to olefin aziridination using said β-diketiminato metal catalysts. In addition, the methods of the present invention include stereoselective C—H bond aminations and olefin aziridinatons. In certain embodiments, the methods are conducted in an aerobic environment. In certain embodiments, the present invention relates to the use of O2 as an oxidant, wherein water is the byproduct of oxidation; this fact avoids the generation of toxic byproducts and renders the methods atom economical.
US08471049B2 Precursors for depositing group 4 metal-containing films
Described herein are Group 4 metal-containing precursors, compositions comprising Group 4 metal-containing precursors, and deposition processes for fabricating conformal metal containing films on substrates. In one aspect, the Group 4 metal-containing precursors are represented by the following formula I: wherein M comprises a metal chosen from Ti, Zr, and Hf; R and R1 are each independently selected from an alkyl group comprising from 1 to 10 carbon atoms; R2 is an alkyl group comprising from 1 to 10 carbon atoms; R3 is chosen from hydrogen or an alkyl group comprising from 1 to 3 carbon atoms; R4 is an alkyl group comprising from 1 to 6 carbon atoms and wherein R2 and R4 are different alkyl groups. Also described herein are methods for making Group 4 metal-containing precursors and methods for depositing films using the Group 4 metal-containing precursors.
US08471048B2 Ruthenium carbonyl complex having tridentate ligand, its production method and use
The present invention relates to a ruthenium carbonyl complex that is represented by the following Formula (1): RuXY(CO)(L)  (1) (in the Formula (1), X and Y, which may be the same or different from each other, represent an anionic ligand and L represents a tridentate aminodiphosphine ligand which has two phosphino groups and a —NH— group), its production method, and a method for production of alcohols by hydrogenation-reduction of ketones, esters, and lactones using the complex as a catalyst.The ruthenium carbonyl complex of the invention has a high catalytic activity and it can be easily prepared and handled.
US08471047B1 Mixed glyceryl esters
The present invention relates to a series of mixed esters of glycerin esters having two distinct alkyl groups present thereon. One is a low melting product, having a melting point of below 70° C. and the other having a melting point of above 90° C. The presence of the two different melting point groups on the glycerin results in a modification of the hardness, spredability and aesthetics of the resulting mixed ester. This ability to alter hardness and skin aesthetics makes the products of the present invention useful in personal care products ranging as additives to pigmented products to minimize syneresis, to stick products alter the hardness, shrinkability and aesthetics of the stick, to pressed powders where they act to modify the compressability of the powders to which they are added as well as the feel achieved when they are applied to the skin.
US08471045B2 Synthesis of statins
The process for the synthesis of statins featuring the use of an early intermediate (4R,6S)-6-(dialkoxymethyl)tetrahydro-2H-pyran-2,4-diol which already possesses the desired stereochemistry corresponding to the final statin.
US08471044B2 Epigallocatechin-3-gallate crystal compositions
Crystalline epigallocatechin-3-gallate compositions and methods of use.
US08471043B2 Platensimycin derivatives, their intermediates, and process for preparing the same, and new process for preparing platensimycin
The present invention relates to novel platensimycin derivatives, their intermediates and preparing methods of the same. Platensimycin is known as an effective antibiotic material having a broad antimicrobial spectrum and its derivatives are also expected to be effective antibiotic candidates. The present invention also relates to a novel preparing method of platensimycin. The intermediates used for the production of platensimycin and its derivatives of the present invention are tricyclo ketone derivatives and tetracyclo derivatives. Tetracyclo derivatives are prepared from tricyclo ketone derivatives prepared by carbonyl ylide [3+2] cycloaddition of dia-zoketone derivative.
US08471042B2 Method for producing 1,6-hexanediol and caprolactone
The invention relates to a process for preparing 1,6-hexanediol and caprolactone, preferably with at least 99.5% purity, which are especially virtually free of 1,4-cyclohexanediols, from a carboxylic acid mixture which is obtained as a by-product of the catalytic oxidation of cyclohexane to cyclohexanone/cyclohexanol with oxygen or oxygen-comprising gases and by water extraction of the reaction mixture, by hydrogenating the carboxylic acid mixture, esterifying and hydrogenating a substream to hexanediol and cyclizing 6-hydroxycaproic ester, the 1,4-cyclohexanediols being removed either in the course of fractionation of the esterification mixture or last from the caprolactone.
US08471040B2 Serotonin reuptake inhibitors
In one aspect, the invention relates to compounds of formula I: where X, Y, R1, R2, R3, R4, R4, and n are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
US08471034B2 Niacin prodrugs and deuterated versions thereof
The invention relates to prodrugs of niacin and their use in pharmaceutical composition and therapeutic treatment of disease.
US08471031B2 Process for the preparation of sterically hindered nitroxyl ethers
The present invention relates to a novel process for the preparation of a sterically hindered nitroxyl ether from the corresponding sterically hindered nitroxyl radical by reacting it with a carbonyl compound and a hydroperoxide. The compounds prepared by this process are effective stabilizers for polymers against harmful effects of light, oxygen and/or heat, as flame-retardants for polymers and as polymerization regulators.
US08471019B2 Quinoid systems as organic semiconductors
A semiconducting layer comprising a non-polymeric quinoid heteroacene compound of the formula (I) wherein X stands for O, S or NR, each of R, R1, R2, R3, R4, R5, R6, R7, R8 being independently selected from hydrogen and an organic residue, or 2 or more thereof together forming one or more annealed rings, which may be substituted or unsubstituted, carbocyclic or helerocyclic, aromatic, quinoid or aliphatic, may be used e.g. for the manufacture of a diode, an organic field effect transistor, an organic thin film transistor, or a device containing a diode and/or an organic field effect transistor and/or organic thin film transistor.
US08471014B2 Process of making gyrase and topoisomerase IV inhibitors
The present application is directed to compounds, intermediates and methods for preparing compounds of formula (I) or a pharmaceutically acceptable salts thereof, wherein R is H or F, and each of R3, R4, and R5 are as defined herein. The compounds of formula (I) and pharmaceutical compositions comprising said compounds and salts inhibit bacterial gyrase and/or Topo IV and are useful in treating bacterial infections.
US08471012B2 Hydrated form of erlotinib free base and a process for preparation of erlotinib hydrochloride polymorph form a substantially free of polymorph form B
The present invention provides a novel and stable hydrated form of erlotinib free base, and a process for its preparation thereof. The present invention also provides a process for preparation of erlotinib hydrochloride crystalline polymorph a substantially free of polymorph B. The present invention further relates to erlotinib hydrochloride crystalline particles having mean particle size (D50) ranging from about 4 μm to 15 μm and 90 volume-% of the particles (D90) ranging from about 14 μm to 30 μm, to the methods for the manufacture of said crystalline particles, and to pharmaceutical compositions comprising said crystalline particles.
US08471009B2 (EN) 2-alkylamino-3-arylsulfonyl-cycloalcano [e OR d] pyrazolo [1,5-A]pyrimidines / antagonists of serotonin 5-HT6 receptors, methods for the production and the use thereof
The invention relates to substituted 2-alkylamino-3-(arylsulfonyl)cycloalkyl[e or d]pyrazolo[1,5-a]pyrimidines, to serotonin 5-HT6 receptor antagonists, to novel drug substances and pharmaceutical compositions comprising the said compounds as active ingredients, and to novel medicaments and method for treatment and prophylaxis of various CNS diseases.2-Alkylamino-3-arylsulfonylcycloalkyl[e]pyrazolo[1,5-a]pyrimidines of general formula 1 and 2-alkylamino-3-arylsulfonylcycloalkyl[d]pyrazolo[1,5-a]pyrimidines of general formula 2, wherein: R1 is hydrogen or C1-C3 alkyl; R2 is C1-C3 alkyl; R3 is hydrogen, one or more optionally identical halogen atoms, C1-C3 alkyl or hydroxyl group optionally substituted with C1-C3 alkyl; n is the whole numbers 1, 2 or 3.
US08471002B2 Beta-serum dairy products, neutral lipid-depleted and/or polar lipid-enriched dairy products, and processes for their production
Processes for producing dairy products having lower levels of neutral lipids, and/or higher levels of polar lipids, by extraction using near critical carbon dioxide or dimethyl ether. These products may be used as ingredients in infant formulas. Infant formulas containing beta-serum are also claimed. “Beta-serum” means an aqueous dairy ingredient separated from dairy streams containing greater than 60% fat which have been through phase inversion from an oil-in-water to a water-in-oil emulsion, such as the serum produced during the production of butter oil.
US08470999B2 Oligonucleotides for treating inflammation and neoplastic cell proliferation
There is provided oligonucleotides directed against the CCR3 receptor and the common beta sub-unit of IL-3, IL-5 and GM-CSF receptors. The oligonucleotides are useful to inhibit general inflammation, including inflammation associated with asthma, COPD, allergy, Cystic fibrosis (CF), hypereosinophilia and neoplastic cell proliferation such as cancer.
US08470992B2 Anti-ILT7 antibody
An antibody binding to IPC was obtained by using an animal cell in which a cell membrane protein associatable with ILT7 was co-expressed as an immunogen. The antibody of the invention has a high specificity which allows immunological distinction between other ILT family molecules and ILT7. The anti-ILT7 antibody of the invention bound to IPC and inhibited the activity thereof. With the anti-ILT7 antibody of the invention, the IPC activity can be inhibited and an interferon-related disease can be treated or prevented. ILT7 expression is maintained even in IPC in the presence of IFNα. Therefore, an inhibitory action of IPC activity by the anti-ILT7 antibody can be expected even in an autoimmune disease patient with an increased production of IFNα.
US08470988B2 Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
The present invention provides single-stranded and double-stranded oligonucleotides comprising at least one aralkyl ligand that improvise the pharmacokinetic properties of the oligonucleotide. The aralkyl ligands of the present invention include naproxen, ibuprofen, and derivatives thereof. The present invention also provides method for modulating gene expression using the modified oligonucleotide compounds and compositions comprising those modified oligonucleotides.
US08470983B2 L-sugar colon cleansing agent and uses thereof
Disclosed is L-glucose monohydrate and compositions thereof. Also disclosed are methods for making L-glucose monohydrate and compositions thereof. Further disclosed are methods for colonic cleansing using L-sugars, such as L-glucose monohydrate, and compositions and kits useful for colonic cleansing.
US08470980B2 Extracellular targeted drug conjugates
The present invention relates to, inter alia, extracellular drug conjugates (EDC) in which an antibody or other targeting agent (e.g. a targeting moiety) is linked to a drug through a linker (e.g. a non-cleavable linker). These conjugates are useful in the treatment of disease and/or as a tool in the evaluation of biological systems.
US08470978B2 Method for separating viable cells, apoptotic and dead cells
Described are methods of separating viable cells, apoptotic cells and dead cells and antibodies or use in such methods. The antibodies may also be used in treatment of inflammatory disease, cancer and in wound healing.
US08470977B2 Antibody against the CSF-1R
The present invention provides antibodies specific for the CSF-1R, compositions comprising said antibodies and methods of treatment using such compositions.
US08470976B2 Methods and compositions for targeting macromolecules into the nucleus
The present invention includes compositions, methods and kits for directing an agent across the nuclear membrane of a cell. The present invention includes a Karyopherin beta2 translocation motif in a polypeptide having a slightly positively charged region or a slightly hydrophobic region and one or more R/K/H-X(2-5)-P-Y motifs. The polypeptide targets the agent into the cell nucleus.
US08470975B2 Collagen mixture and method of making the same
A collagen mixture having a portion of unhydrolyzed eggshell membrane collagen and Avian collagen.
US08470974B2 Method for highly sensitive detection of protein-protein interaction
The present invention intends to provide an assay system using split luciferase that has a remarkably high detection sensitivity. In an embodiment, binding of mutually binding first and second proteins is detected by preparing a first fusion protein comprising the first protein fused with a peptide having the amino acid sequence of amino acid SEQ ID NO: 1 and a second fusion protein comprising the second protein fused with a peptide having an amino acid sequence selected from the group consisting of amino acid SEQ ID NOS: 2 to 6, and allowing the first fusion protein to bind with the second fusion protein to form a complex, and detecting luminescence emitted from the complex.
US08470961B2 Naphtalene-imide semiconductor polymers
Disclosed are new semiconductor materials prepared from naphthalene-imide copolymers. Such polymers can exhibit desirable electronic properties and can possess processing advantages including solution-processability and/or good stability at ambient conditions.
US08470960B2 Electroactive materials
There is provided an electroactive material having Formula I wherein: Q is the same or different at each occurrence and can be O, S, Se, Te, NR, SO, SO2, or SiR3; R is the same or different at each occurrence and can be hydrogen, alkyl, aryl, alkenyl, or alkynyl; and R1 through R6 are the same or different and can be hydrogen, alkyl, aryl, halogen, hydroxyl, aryloxy, alkoxy, alkenyl, alkynyl, amino, alkylthio, phosphino, silyl, —COR, —COOR, —PO3R2, —OPO3R2, or CN.
US08470957B2 Method for producing bischloroformate compound, polycarbonate oligomer having small number of monomers and solution containing bischloroformate compound
A dihydric phenol compound represented by the following formula (2), a phosgene compound, and an aliphatic tertiary amine are mixed together using a hydrophobic organic solvent to produce bischloroformate that is represented by the following formula (1) and has an average number of repeating units (n) of 1.99 or less. In the formulae (1) and (2), Ar is a divalent aromatic group.
US08470955B2 Poly(arylene ether) copolymer having cation-exchange group, process of manufacturing the same, and use thereof
The present invention relates to a poly(arylene ether) copolymer having a cation exchange group, a method for manufacturing the same, and use thereof. The poly(arylene ether) copolymer having the cation exchange group according to the present invention has excellent physical characteristics, ion exchanging capacity, metal ion adsorption capacity and a processability, and thus can be molded in various shapes and can be extensively applied to various fields such as recovering of organic metal, air purification, catalysts, water treatment, medical fields and separating of proteins.
US08470953B2 Sealing material for optical element and sealed optical element
A sealing material for optical elements with excellent transparency, crack resistance, and heat resistance which can produce a cured product of the sealing material and a sealed optical element are provided. The sealing material for optical elements comprising a compound with a ladder structure, which contains a repeating unit of the following formula (A) in the molecule as a major component, the compound being obtained by condensing a compound (1) shown by the formula, R1Si(OR3)P(X1)3-p, and a compound (2) shown by the formula, R2Si(OR4)q(X2)3-q, at a molar ratio of 1:9 to 10:0 in the presence of a phosphoric acid catalyst, wherein R1 represents a group having a reactive functional group, R2 represents an alkyl group having 1 to 20 carbon atoms, R3 and R4 individually represents an alkyl group having 1 to 6 carbon atoms, X1 and X2 individually indicate a halogen atom, p and q individually represent an integer from 0 to 3, and l, m, and n individually represent 0 or an arbitrary integer, provided that l and n are not 0 at the same time.
US08470951B2 Silicone composition suitable for cross-linking by dehydrocondensation in the presence of a metal catalyst
A silicone composition is described that includes components having SiH/SiOH group and that can be polymerized/cross-linked by a dehydrocondensation reaction in the presence of a catalyst such as an iron-based complex or salt, requiring a low activation temperature.
US08470949B2 Non-yellowing low VOC mineral surface enhancer
Low VOC mineral surface enhancer compositions are non-yellowing and contain a condensable aminoorgano-functional organopolysiloxane fluid, a condensable organopolysiloxane resin, and a condensation catalyst. The compositions provide a durable, color enhancing wet look to mineral surfaces to which they are applied.
US08470948B2 High refractive index polymers
A polymer and a method of forming a polymer are provided. The polymer has the general structure (I): wherein M is a main group element, a transition metal element, or an organic moiety; X is a main group element selected from S, P, As, Se, Te, and Sb; R1 is a direct bond between M and the ethylene group depicted between M and X or a hydrocarbyl linking moiety having between 1 and about 9 carbon atoms; R2 is a hydrocarbyl moiety; R3 is an organic linking group; Y has a value of 0, 1, 2, 3, or 4; Z has a value of 0, 1, 2, 3, or 4; YY has a value of 0, 1 or 2; and Y, YY, and Z are such that the total number of moieties bonded to M is 3, 4, 5, or 6.
US08470947B2 Ethylenic polymer
Disclosed is an ethylenic polymer having a long characteristic relaxation time. The ethylenic polymer satisfies the following requirements: (a) the ethylenic polymer is a non-crosslinked ethylenic polymer; (b) the number of long-chain branches (LCB) per 1000 carbon atoms is 0.1-1.5 inclusive; (c) the intrinsic viscosity [η] is 1.0-3.0 dl/g inclusive; and (d) the ratio (G′/G″) of the storage modulus (G′) to the loss modulus (G″), determined by dynamic viscoelasticity measurement at 190° C. and at an angular frequency of 0.1 rad/sec is 0.8 or more and 4.0 or less.
US08470944B2 Polynorbornene pervaporation membrane films, preparation and use thereof
Embodiments in accordance with the present invention provide forming polynorbornenes useful for forming pervaporation membranes, the membranes themselves and methods of making such membranes.
US08470941B2 Catalyst for homopolymerizing and copolymerizing propylene and its preparation and use
A catalyst for homopolymerizing and copolymerizing propylene and its preparation and use. The catalyst component includes titanium compound containing at least one Ti-halogen bond and at least two kinds of electron donor compounds A and B supported on MgCl2.nROH adduct, wherein the electron donor compound A is a compound of formula (I), the electron donor compound B is ester or ether compound; the molar ratio between compound A and compound B is 0.1-5; the molar ratio between the total amounts of the two kinds of electron donors and MgCl2.nROH is 0.01-1, based on the amount of MgCl2.nROH; and the molar ration between the titanium compound containing Ti-halogen bond and MgCl2.nROH is 1-200. The catalyst has high activity, high stereospecificity and good copolymerization performance. In addition, the morphology of the polymer obtained therefrom is good.
US08470940B2 Complexes and method for synthesis of group 4 organometallics grafted on anions olefin oligomerization and polymerization method
Novel group 4 organometallic compounds, supported on anions by means of at least one covalent metal-oxygen bond, are obtained by reaction of at least one borate or aluminum comprising at least one hydroxy group with at least one group 4 transition metal compound. These compounds are used in a catalytic composition implemented in an olefin oligomerization or polymerization method.
US08470938B2 Resin composition for printed wiring board, prepreg, and laminate obtained with the same
An epoxy resin composition for use in producing a prepreg for printed wiring boards excellent in appearance, flame retardancy, etc., which comprises an epoxy resin, a phenolic novolak, and a curing accelerator. It is characterized in that the epoxy resin comprises an epoxy (a) and an epoxy (b), wherein the epoxy (a) is a brominated epoxy resin which is obtained by reacting/mixing a bisphenol A epoxy resin with tetrabromobisphenol A and has an epoxy equivalent of 350 to 470 g/eq and an n=0 component content of 20 to 35% in terms of areal percentage in a GPC chart, and the epoxy (b) is at least one bifunctional epoxy resin which is obtained by reacting any one selected from the group consisting of bisphenol A, bisphenol F, and tetrabromobisphenol A with epichlorohydrin and has an n=0 component content as determined from a GPC chart of 60% or higher.
US08470937B2 Curable composition for semiconductor encapsulation
Provided are a curable composition for semiconductor encapsulation which produces a cured product that is excellent in heat resistance, electrical insulation properties at high temperatures, flexibility and heat cycle resistance, and a semiconductor device encapsulated by curing this curable composition. Specifically, there is provided a curable composition for semiconductor encapsulation containing, as component (A), a particular SiH group-containing siloxane compound; as component (B), a particular vinyl group-containing siloxane compound; as component (C), a compound having at least three SiH groups or at least three vinyl groups; and as component (D), a hydrosilylation catalyst.
US08470934B2 Polycarbonate compositions having improved surface hardness
The present invention relates to polycarbonate compositions having improved surface hardness, processes for the preparation thereof and the use thereof for the production of blends, shaped articles and extrudates.
US08470928B2 Adhesives with acoustic damping effect
A one- or two-component adhesive containing: a) a binding agent having reactive isocyanate groups or silane groups, and b) a nonreactive polymer having a glass transition temperature, measured by means of DSC, in the range from −40° C. to +60° C. This preferably has, in a cured state, at a temperature at least in the range from −10 to +50° C., a dynamic mechanical loss factor tan δ of at least 0.4 at a frequency in the range from 10 to 400 Hz. Use of an adhesive of this kind for the adhesive bonding of components in the manufacture or repair of vehicles, in particular for bonding windows into place in the context of direct glass bonding.
US08470927B2 Process for production of polymer polyols
The present invention provides a process for preparing a polymer polyol (PMPO) by alkoxylating a starter compound(s) having active hydrogen atoms in the presence of a double metal cyanide (DMC) catalyst, radical initiator(s) and optionally PMPO stabilizers and simultaneously polymerizing unsaturated monomer(s) with radical initiator(s). The polymer polyols (PMPOs) made by the inventive process may find use in the preparation of polyurethane foams and elastomers.
US08470926B2 Unsaturated polyester resin
The present invention relates to an unsaturated polyester resin comprising itaconate ester units as reactive unsaturation, wherein the resin comprises itaconate, citraconate and mesaconate ester units. Preferably, the resin comprises itaconate, citraconate and mesaconate ester units in an amount of from 40 to 90 mol % itaconate, from 2 to 30 mol % citraconate and from 5 to 40 mol % mesaconate in which 100 mol % is the total amount of itaconate, citraconate and mesaconate esters units.
US08470920B2 Polyolefin composition for an interior sheet/film
The present invention relates to a polyolefin composition for an interior sheet/film. The polyolefin composition of the present invention for an interior sheet comprises 70 to 99 wt % of polyolefin and 1 to 30 wt % of modified polyethylene terephthalate having a melting point of 130 to 180° C. The polyolefin composition of the present invention is environmentally friendly and has good physical properties such as workability, printing characteristics, and adhesiveness. In addition, sheets having various thicknesses can be produced by extrusion without having to stretch the sheets, and thus the sheets can be used separately or in combination in various application fields.
US08470917B2 Production method of polyimide solution and fluorinated polyimide solution
The invention aims to provide a method by which a solution of polyimide can be easily obtained. Further, the invention aims to provide a fluorinated polyimide solution by which fluorinated polyimide excellent especially as an optical material and an electronic functional material can easily be produced. The production method of the soluble polyimide solution according to invention is characterized by mixing a mixture containing a polyamide acid, a cyclodehydration reagent, and a solvent by a rotation-revolution mixing method. Further, the fluorinated polyimide solution of the invention is a solution of polyimide defined by the following formula (II): wherein, X and Y independently represent divalent organic groups; Z represents chlorine atom, bromine atom, or iodine atom; p represents an integer of 1 to 3; q represents an integer of 0 to 2; and p+q=3.
US08470916B2 Halogen-free flame retardants
A halogen-free flame retardant obtainable by polycondensation of phosphoric monomers with esterifying monomers is provided. The phosphoric monomer is an adduct of 9,10-dihydro-9-oxa-10-phospha-phenanthrene-10-oxide (DOPO) and ring substituted DOPO derivatives to unsaturated carboxylic acids. Monovalent and polyvalent alcohols are used as esterifying monomers. The flame retardant has an average molecular weight of more than 20,000 and an average degree of polymerization Pn of at least 55, and is preferably used for the production of polyamide fibers and polyester fibers by melt spinning.
US08470909B2 Tire puncture sealant
A tire puncture sealant is disclosed and described. Such a sealant may include a natural rubber latex and a surfactant, wherein a content of the surfactant is from 1.0 to 6.0 mass % of a solid content of the natural rubber latex and the surfactant includes a non-ionic surfactant and an anionic surfactant at a mass ratio where the non-ionic surfactant/the anionic surfactant=1.0/1.0 to 1.0/5.0.
US08470907B2 Additive for cementing wells
An additive based on a polyalkylenimine and a sulphonated formaldehyde-containing condensate and its use as a fluid loss additive in the cementing of wells in the mineral oil and natural gas sector is claimed. Polyethylenimine, polypropylenimine and polybutylenimine are suitable as typical representatives of the polyalkylenimines and may also be derivatised. Preferred condensates are acetone/formaldehyde resins. Those additives according to the invention which are subjected to maturing, in particular by allowing to stand, prior to their use achieve a particularly low fluid loss value.
US08470906B2 Ionic silicone hydrogels having improved hydrolytic stability
The present invention relates to ionic silicone hydrogel polymers displaying improved thermal stability. More specifically, the present invention relates to a polymer formed from reactive components comprising at least one silicone component and at least one ionic component comprising at least one anionic group. The polymers of the present invention display good thermal stability and desirable protein uptake.
US08470905B2 Gingival tissue retraction device and method
A method and a device for effecting the cordless retraction of the gingival sulcus tissue that includes a dam shaped to be fitted onto a tooth. In one embodiment, the well of the dam is pre-filled with a predetermined amount of a flowable retraction material having a heavy viscosity or putty consistency. In another embodiment a hydrophilic material is added. The preloaded tooth dam is fitted to a prepared tooth so that when pressure is applied onto the tooth dam, the retraction material is displaced under pressure and forced into the sulcus, causing the gingival tissue to retract away from the tooth to enlarge the gingival sulcus. In another embodiment the cap is filled with a dilatant material. In another embodiment, the cap is filled with an impregnated compressible porous material. In yet another embodiment, the cap is pre-dosed with an astringent or hemostatic agent.
US08470904B2 Radiation-curable ink composition, ink jet recording method, and recorded matter
Provided are a radiation-curable ink composition including phenoxyethyl acrylate (A) in an amount of from 20 to 55 mass % of the total reaction components, a multifunctional acrylate (B) in an amount of from 20 to 50 mass % of the total reaction components, and a black pigment (F1); and a radiation-curable ink composition including phenoxyethyl acrylate (A) in an amount of from 20 to 55 mass % of the total reaction components, a multifunctional acrylate (B) in an amount of from 10 to 50 mass % of the total reaction components, and a yellow pigment (F2).
US08470894B2 Hydrolysis resistant organomodified trisiloxane ionic surfactants
The present invention provides for a composition comprising a siloxane having the formula: M1DM2 wherein M1=(R1)(R2)(R3)SiO1/2; M2=(R4)(R5)(R6)SiO1/2 and D=(R7)(Z)SiO2/2 where R1, R2, R3 R4, R5, R6 and R7 are each independently selected from the group consisting of 1 to 4 carbon monovalent hydrocarbon radicals, aryl, and a hydrocarbon group of 4 to 9 carbons containing an aryl group; Z is a pendant hydrophilic ionic group selected from the group consisting of R8—RA, R9-RC, and R10—RZ; RA being an anionic substituent, RC a cationic substituent or RZ a zwitterionic substituent on the D group wherein said siloxane has an enhanced resistance to hydrolysis at a pH below 6 or a pH above 7.5.
US08470890B2 Method for enhancing the bioavailability of ospemifene
This invention relates to a method for enhancing the bioavailability of a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to the individual in connection with the intake of food.
US08470880B2 Methods of reducing hair loss and/or facilitating hair growth and/or regrowth
The present disclosure relates to methods of retarding hair loss or facilitating hair growth and/or regrowth. More specifically, the present disclosure relates to methods of using the disclosed compositions to increase the rate of terminal hair growth and/or regrowth in a mammal.
US08470877B2 2-phenylethylamino derivatives as calcium and/or sodium channel modulators
2-Phenylethylamino substituted carboxamide derivatives and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies are presented.
US08470873B2 Vitamin E succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
The present invention provides vitamin E succinate (VES)-stabilized compositions, methods for the preparation thereof and methods useful for the in vivo delivery of substantially water insoluble and optionally chemically unstable pharmacologically active agents (such as docetaxel).
US08470871B2 Ligands that modulate RAR receptors
Novel ligand compounds having the general formula (I): and pharmaceutical/cosmetic compositions comprised thereof are useful in human and veterinary medicine or, alternatively, in cosmetics.
US08470869B2 Salts of perindopril
The present invention relates to new salts of perindopril, particularly to a new calcium salt and new amine salts of perindopril, to a process for their preparation and to a pharmaceutical formulations containing the new salts.
US08470866B2 Isoindolinone derivatives
The present invention relates to compounds of the formula I, as well as pharmaceutically-acceptable salts thereof, pharmaceutical compositions containing said compounds and methods of using said compounds in the treatment or prophylaxis of diseases and disorders. The compounds and compositions disclosed herein are glucokinase activators useful for the treatment or prophylaxis of metabolic diseases and disorders, for example diabetes mellitus, including type II diabetes mellitus.
US08470863B2 Derivatives and analogs of chroman as functionally selective ALPHA2C adrenoreceptor agonists
In its many embodiments, the present invention provides a novel class of chroman compounds of formula I as α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of prepaxing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions. wherein J is: Z is —[C(Rc)(Rc)]x—, where x is 1, 2, or 3.
US08470860B2 Phenyl-sulfamates as aromatase inhibitors
There is provided a compound of Formula I wherein X, Y and Z are each independently of each other an optional linker group; R1 is a ring system; R2 is selected from hydrocarbyl groups, oxyhydrocarbyl groups, cyano (—CN), nitro (—NO2) and halogens; R3 and R4 are independently selected from H and hydrocarbyl, ring A and B are independently optionally further substituted.
US08470858B2 Agave syrup extract having anticancer activity
The present invention comprises an agave syrup stored for at least eight weeks, having phytochemicals preferably selected from the group comprising flavonoids, polycosanols and sapogenins, which provide anticancerigen and antioxidant properties to the agave syrup. It is also described an extract of said agave syrup and a related method for its extraction and application for inhibiting the growth of cancer cells.
US08470854B2 Lactam-containing compounds and derivatives thereof as factor XA inhibitors
The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4  I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
US08470852B2 Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators
The invention relates to substituted 2-amino-quinoline-3-carboxamides, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
US08470847B2 Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics
The disclosure relates to 7-alkynyl-1,8-naphthyridones of formula (I): wherein R1, R2, R3, and R4 are as defined in the disclosure, to compositions containing them, to processes for preparing them, and to their use in therapeutics.
US08470846B2 Remedy for psychoneurotic diseases
A medicinal preparation for preventing and/or treating psychoneurotic diseases such as integration dysfunction and Alzheimer's disease which contains tropisetron or its pharmaceutically acceptable salt as the active ingredient.
US08470839B2 N1-acyl-5-fluoropyrimidinone derivatives
This present disclosure is related to the field of N1-acyl-5-fluoropyrimidinones and their derivatives and to the use of these compounds as fungicides.
US08470836B2 Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent
Disclosed herein are novel compounds of Formula (1) as defined in the specification having excellent inhibitory activity against dipeptidyl peptidase-IV (DPP-IV), methods of preparing the same and pharmaceutical compositions comprising the same as an active agent.
US08470829B2 Imidazolidine derivative and use thereof
An imidazole derivative represented by formula (I): wherein Q is: A is hydrogen, halogen, or a substituted or unsubstituted C1-4 alkyl group; E is independently selected from a C1-6 alkyl group; R2 and R3 are independently selected from C1-6 alkyls; X1 and X2 are independently selected from O and S; Y is selected from a substituted or unsubstituted arylene group and a substituted or unsubstituted divalent 5- or 6-membered monocyclic or 8- to 10-membered condensed heterocyclic group; Z is —CON(—Ra)—, —CO—, —OOO—, —NRa—C(═NH)NRb—, —NRa—C(═N—CN)NRb—, —N(—Ra)COO—, —C(═NH)—, —SO2—, —SO2N(—Ra)—, —SO2NR1—, —N(—Ra)CO—, —N(—Ra)CON(—Rb)—, —N(COR1)CO—, —N(—Ra)SO2—, —N(SO2R1)SO2—, —N(—Ra)— or —N(—Ra)SO2N(—Rb)—; R1 is independently a hydrogen atom, a hydroxyl group, or substituted or unsubstituted group selected from C1-6 alkyl group, heterocyclic group, aryl group, C3-8 cycloalkyl group and C3-8 cycloalkenyl group; or salt or prodrug thereof.
US08470828B2 Anellated pyridine compounds
The present invention is concerned with novel dual modulators of the 5-HT2A and D3 receptors of formula (I) wherein X, Y, A, R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as therapeutics.
US08470823B2 Saturated bicyclic heterocyclic derivatives as SMO antagonists
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.
US08470822B2 Folate mimetics and folate-receptor binding conjugates thereof
This present disclosure relates to folate mimetics and their use in therapeutic and diagnostic applications. More particularly, the disclosure relates to using des-glutamyl folic acid analogs recognized by and selectively bound by folate receptors and other folate binding proteins and the use of such analogs for targeted delivery of diagnostic or therapeutic agents to folate-receptor bearing cell populations.
US08470820B2 Nitrogen-containing heteroaryl derivatives
The invention is concerned with novel nitrogen-containing heteroaryl derivatives of formula (I) wherein R1, R2, R3, R4, R5, A1, A2, and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as medicaments.
US08470819B2 Benzimidazole and aza-benzimidazole carboxamides
This invention provides compounds of Formula I which are PAFR antagonists: I and the pharmaceutically acceptable salts thereof. The compounds are useful for treating PAF-mediated disorders, and can be used in methods for treating atherosclerosis and preventing or reducing risk for atherosclerotic disease events. The compounds are also useful for treating or ameliorating pain, e.g. inflammatory pain and/or nociceptive pain, and for treating or ameliorating autoimmune and/or inflammatory diseases, among other conditions.
US08470818B2 Compounds and methods for kinase modulation, and indications therefor
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
US08470814B2 Diazepinedione derivative
A diazepinedione derivative represented by the formula (I) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist: wherein R1 represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or the like, R2 and R3 represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a halogen atom, or the like, R4 and R5 represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or the like, and W represents tetrazole or the like.
US08470808B2 Oxidant scavengers for treatment of type I diabetes or type II diabetes
The present invention relates, in one embodiment, to a method of preventing or treating diabetes using low molecular weight antioxidants. In a further embodiment, the invention relates to a method of protecting and/or enhancing viability of cells/tissues/organs during isolation (harvesting), preservation, expansion and/or transplantation. In yet another embodiment, the present invention relates to a method of inducing immune tolerance. The invention also relates to compounds and compositions suitable for use in such methods.
US08470806B2 Perhexiline for treating chronic heart failure
Disclosed are methods for the treatment of chronic heart failure, comprising administering to an animal in need thereof an effective amount of perhexiline, or a pharmaceutically acceptable salt thereof, to treat said chronic heart failure. The chronic heart failure may be non-ischaemic or ischaemic. Also disclosed is the use of perhexiline in the manufacture of a medicament to treat chronic heart failure, including chronic heart failure of a non-ischaemic origin and chronic heart failure of an ischaemic origin.
US08470802B2 Sensory modifier
Sensory modifiers and compositions comprising sensory modifiers are described. The sensory modifiers comprise polysaccharide carbohydrate having at least about 75% by weight amylopectin and the polysaccharide carbohydrate has been treated and swollen with a substantially anhydrous solvent.
US08470799B2 Compositions and methods for inhibiting expression of the HAMP gene
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the HAMP gene (HAMP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the HAMP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HAMP gene expression and the expression of the HAMP gene using the pharmaceutical composition.
US08470798B2 Cancer cell-specific apoptosis-inducing agents that target chromosome stabilization-associated genes
The present inventors discovered that inhibition of the expression of various genes associated with chromosome stabilization induces cancer cell-specific apoptosis and inhibits cell proliferation. Compounds that inhibit expression of a gene associated with chromosome stabilization or inhibit the function of a protein encoded by such a gene are thought to have cancer cell-specific apoptosis-inducing effects.
US08470795B2 Antisense modulation of kinesin-like 1 expression
Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding kinesin-like 1. Methods of using these compounds for modulation of kinesin-like 1 expression and for treatment of diseases associated with expression of kinesin-like 1 are provided.
US08470793B2 Down-regulation of mortalin by siRNA
Use of a siRNA molecule selected from the group consisting of SEQ ID NO: 173 to 344 for treating a disease associated with a pathological cell population in a subject in need thereof is disclosed. Pharmaceutical compositions and articles of manufacture comprising the siRNAs are also disclosed.
US08470790B2 Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
Nucleic acid vectors encoding light-gated cation-selective membrane channels, in particular channelrhodopsin-2 (Chop2), converted inner retinal neurons to photosensitive cells in photoreceptor-degenerated retina in an animal model. Such treatment restored visual perception and various aspects of vision. A method of restoring light sensitivity to a retina of a subject suffering from vision loss due to photoreceptor degeneration, as in retinitis pigmentosa or macular degeneration, is provided. The method comprises delivering to the subject by intravitreal or subretinal injection, the above nucleic acid vector which comprises an open reading frame encoding a rhodopsin, to which is operatively linked a promoter and transcriptional regulatory sequences, so that the nucleic acid is expressed in inner retinal neurons. These cells, normally light-insensitive, are converted to a light-sensitive state and transmit visual information to the brain, compensating for the loss, and leading to restoration of various visual capabilities.
US08470789B2 Method for inducing and accelerating cells
The present invention relates to a method for the production of functional dendritic cells wherein CD34 positive cells are contacted with compounds inducing and accelerating the differentiation of these CD34 positive cells into functional dendritic cells. More in particular, the CD34 positive cells are contacted with anthracyclines and/or anthracenediones. In another aspect, the current invention relates to the cells obtainable by the method according to the invention. In a further aspect the current invention relates to the use of compounds such as anthracyclines and/or anthracenediones that induce and accelerate the differentiation of CD34 positive cells into functional dendritic cells in the manufacture of a medicament for inducing an immune response in human in need thereof.
US08470787B2 Hydrates of erythromycin salts, preparation and use thereof
A macrolide derivative, i.e., a hydrate of erythromycin salts, has a molecular formula of C37H67NO13.A.nH2O, n=1.0-11.0, in which A is an organic acid or an organic acids, selected from lactobionic acid, thiocyanic acid, maleic acid, fumaric acid, thiocyanic acid, acetic acid, methanesulfonic acid, benzenesulfonic acid, nicotinic acid, lactic acid, citric acid, tartaric acid, aspartic acid, glutamic acid and phosphoric acid. The hydrate has better storage stability and is suitable for the manufacture of a medicament.
US08470786B2 Pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same
The present invention relates to pyrroloquinolinyl-pyrrolidine-2,5-dione compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing pyrroloquinolinyl-pyrrolidine-2,5-dione compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.
US08470784B2 Methods and compositions for preventing or treating ophthalmic conditions
The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
US08470776B2 Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof
The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.
US08470774B2 Deoxycorticosterone induced elastin production
Compositions and methods for inducing the deposition of elastin in skin by administering compositions including a mineralocorticoid, such as, for example, aldosterone and, optionally, a secondary active agent for enhancing or modulating the effect of the mineralocorticoid are described herein.
US08470773B2 Thiophenes as glucagon receptor antagonists, compositions, and methods for their use
The present invention relates to compounds of the general formula: wherein R1, R2, R3, R5, s, and Z are selected independently of each other and are as defined herein, to compositions comprising the compounds, and methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.
US08470771B2 Method and medicament for inhibiting the infection of influenza virus
The invention relates to a process for inhibiting the infection of influenza viruses and a polypeptide or protein medicine used therein. More particularly, the invention involves a process for inhibiting the highly pathogenic avian influenza virus (such as H5N1 subtype) infection and human influenza virus (such as H1N1 subtype and H3N2 subtype) infection, as well as the polypeptide or protein involved therein, and a polynucleotide encoding the polypeptide or protein and a vector or host cell expressing said polypeptide or protein.
US08470769B2 Method of treatment of bacterial infection by administration of poly-lysine
The present invention relates to peptides comprising amino acids according to Formula I ((X)l(Y)m)n  (I) wherein l, m and n are integers from 0 to 10; X and Y, which may be the same or different, are an amino acid selected from the group consisting of hydrophobic amino acids and/or cationic amino acids, together with methods for the use of the peptides in the treatment of microbial infections.
US08470768B2 Peptide epitopes of apolipoprotein B
The present invention relates to antibodies raised against fragments of apolipoprotein B, in particular defined peptides thereof, for immunization or therapeutic treatment of mammals, including humans, against ischemic cardiovascular diseases, using one or more of the antibodies.
US08470767B2 Methods and compositions for the reduction of neutrophil influx and the treatment of bronchopulmonary displasia, respiratory distress syndrome, chronic lung disease, pulmonary fibrosis, asthma and chronic obstructive pulmonary disease
The present invention relates generally to the use of recombinant human CC10 (rhCC10), also known as recombinant human uteroglobin, for use as a therapeutic in the treatment of Respiratory Distress Syndrome (RDS), Bronchopulmonary dysplasia (BPD), chronic lung disease and/or pulmonary fibrosis, Asthma and Chronic Obstructive Pulmonary Disease (COPD). More particularly, the invention provides methods, including broadly the critical dosage ranges of rhCC10, which may be administered to safely and effectively treat the aforementioned conditions. The invention further provides a composition useful in administering rhCC10 to humans.
US08470765B2 Polypeptides and antibacterial or antiseptic use of same
A novel polypeptide, and an antibacterial agent, antifungal agent and/or antiseptic containing as an effective ingredient the polypeptide are disclosed. The polypeptide of this invention has an amino acid sequence shown in SEQ ID NOs:1 to 12 and 13 to 31. This antibacterial agent, antifungal agent and/or antiseptic is useful for the prevention, amelioration or treatment of diseases such as burn, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliterans, cellulitis, acute lymphangitis, lymphadenitis, erysipelas, skin abscess, necrotizing subcutaneous infection, staphylococcal scalded skin syndrome (SSSS), folliculitis, facial furuncle, suppurative hidradenitis, carbuncle, infectious paronychia, erythrasma and severe infection (sepsis).
US08470763B2 Alpha-amino-N-substituted amides, pharmaceutical composition containing them and uses thereof
Disclosed are a series of α-amino-N-substituted amide compounds having a structure of the following formula, the pharmaceutically acceptable salts thereof, and the pharmaceutical composition comprising the same. The α-amino-N-substituted amide compounds or the pharmaceutically acceptable salts thereof according to the present invention have anti-tumor and/or anti-cancer activities in vivo and in vitro, can effectively depress the growth of various tumor cells and/or cancer cells, and thus can be used in preparing drugs for treating tumors and/or cancers.
US08470756B2 Eco-friendly laundry pretreatment compositions
An eco-friendly liquid composition for pretreatment of fabrics is disclosed. The composition may include one or more nonionic surfactants, water, and optional ingredients such as a small amount of anionic surfactant, protease enzyme, borax, pH adjusting agent, fragrance, and preservative. The one or more nonionic surfactants may include alkyl polyglycoside. If nonionic surfactants other than the alkyl polyglycoside are included, at least 60% of the total nonionic surfactant in the composition is alkyl polyglycoside. The composition may have a Natural Index of at least 98% as defined herein. The composition may be essentially free of any propellant and bleach component.
US08470754B2 Detergent cosmetic compositions comprising at least one amino silicone, and uses thereof
The disclosure relates to novel detergent compositions comprising, in a cosmetically acceptable medium, (A) at least one sulfate or sulfonate anionic surfactant, (B) at least one surfactant chosen from amphoteric and zwitterionic surfactants and (C) at least one amino silicone with a weight-average molecular mass Mw greater than or equal to 75,000, the (sulfate or sulfonate anionic surfactant)/(amphoteric and/or zwitterionic surfactant) weight ratio ranging from 1:1 to 2:1, the total amount of surfactants representing from 4% to 35% by weight relative to the total weight of the final composition. The disclosure also relates to the use of the composition for protecting the coloration of artificially dyed hair.
US08470751B2 Lubricating oil compositions
An internal combustion engine crankcase lubricating oil composition has a phosphorus content of not greater than 0.08 mass % and a metal detergent additive system comprising a calcium salicylate and a magnesium salicylate and having a mass ratio of magnesium atoms to calcium atoms of greater than one.
US08470750B2 Trithiocarbonate derivatives and the use thereof in the form of transfer agents for acrylic acid controlled radical polymerisation
The invention relates to novel sulphur compounds, to the production thereof by a method carried out in an aqueous medium and the use thereof in the form of transfer agents in a method for controlled radical polymerization of acrylic acid and/or acrylic acid with water-soluble monomers in water. The thus obtained polymers are usable in the form of dispersing agents or grinding aid agents and/or aid agents for combined grinding of mineral materials in an aqueous suspension and in the form of dispersing agents directly incorporated into aqueous formulations containing mineral materials.
US08470744B2 High temperature superconductor, in particular improved coated conductor
A coated conductor is provided with improved electrical connection between the conductive layers such as the high temperature superconductor layer and a metal protection layer applied onto the high temperature superconductor layer and the substrate. A method includes obtaining such electrical connection, in particular, creating a coated conductor wherein the substrate is a core covered with the layers all around its periphery.
US08470743B2 Composite superconductor
A composite superconductor and methods of providing same include a superconductor powder dispersed within a conductive polymer matrix.
US08470741B2 Homogeneous liquid saccharide and oil systems
Oil based emulsifiable concentrates containing a liquid saccharide including a) at least one oil component; b) at least one saccharide, particularly a liquid saccharide solution (LS); c) and at least one non-ionic surfactant. The concentrate may also contain at least one of d) at least one surfactant hydrocarbyl saccharide; or e) at least one anionic surfactant; or f) at least one additional oil soluble non-ionic surfactant. The concentrates are typically homogeneous for at least 24 hours and emulsify readily on dilution into water. The concentrates may also contain an antifoaming agent especially a polysiloxane. Upon dilution in water, the emulsions formed from the concentrates are applied to substrates in combination with agrochemically active ingredients, preferably N-phosphonomethylglycine in the form of its soluble salts, to control weeds.
US08470735B2 Coating solution for heat-sensitive color-developing layer, and heat-sensitive recording material
Provided are a coating solution for a thermosensitive color developing layer of excellent storability wherein color development during its storage or during producing a thermal recording material is suppressed, and a thermal recording material with excellent print portion (image portion) storability and suppressed staining in the background color (white background).A coating solution for a thermosensitive color developing layer, which comprises a colorless or pale-colored electron-donating leuco dye, a hindered phenol compound and, as an electron-accepting developer, a diphenylsulfone derivative represented by the following formula (1): wherein the aforementioned hindered phenol compound has an average particle size (D50) of not more than 0.5 μm, and the coating solution has a color tone a* of not less than −4.0 as measured according to JIS Z 8729 and a whiteness W of not less than 62 as measured according to JIS Z 8715.
US08470732B2 Thermosensitive recording material comprising a back coating
A thermosensitive recording material comprising a substrate, a thermosensitive recording layer applied to the front and a back coating which comprises a polyurethane-based-cross-linking component in addition to pigments and binders.
US08470731B2 Oil adsorbent, and method for recovering the same
An oil adsorbent includes a plurality of particles, each being constituted from at least one of an inorganic particle and an organic particle as a core and a polymer covering the core. The plurality of particles are aggregated to form an aggregate so that a porosity of the aggregate is 70% or more.
US08470729B2 Method for storing titanium-containing silicon oxide catalyst
Provided is a method for storing a high active titanium-containing silicon oxide catalyst, characterized in that the catalyst is stored at a relative humidity of 60% or less. The method can be used for a reaction, for example, wherein an oxirane compound is prepared from hydroperoxide and olefinic compound, even after the catalyst has been stored for a long period of time. The titanium-containing silicon oxide catalyst can be suitably employed as a catalyst satisfying the following requirements: (1) an average pore diameter is 10 Å or more, (2) the pores accounting for 90% or more of the total pore volume have a pore diameter of 50 to 200 Å, and (3) a specific pore volume is 0.2 cm cm3/g or more.
US08470728B2 Exhaust gas purifying catalyst
To overcome the problem of a conventional catalyst and to provide an exhaust gas purifying catalyst that meets the requirement concerning Hg oxidation activity and SO2 oxidation activity; i.e., an exhaust gas purifying catalyst which specifically reduces percent SO2 oxidation, while maintaining percent Hg oxidation at a high level.The invention provides an exhaust gas purifying catalyst which comprises a composition containing oxides of (i) titanium (Ti), (ii) molybdenum (Mo) and/or tungsten (W), (iii) vanadium (V), and (iv) phosphorus (P), wherein the catalyst contains Ti, Mo and/or W, and V in atomic proportions of 85 to 97.5:2 to 10:0.5 to 10, and has an atomic ratio of P/(sum of V and Mo and/or W) of 0.5 to 1.5, and an exhaust gas purifying method comprising exposing an exhaust gas containing a nitrogen oxide (NOX) and metallic mercury (Hg) to the catalyst in the presence of ammonia as a reducing agent, to thereby perform reduction of NOX contained in the exhaust gas and oxidation of metallic mercury (Hg) contained in the exhaust gas.
US08470726B2 Alkylation catalysts with low olefin skeletal isomerization activity
A catalyst is presented for use in the production of linear alkylbenzenes. The catalyst includes two zeolites combined to improve the quality of the linear alkylbenzenes. The catalyst includes a first zeolite that is UZM-8 and a second zeolite that is a low silica to alumina ratio zeolite. The second zeolite is also cation exchanged with a rare earth elements to provide a zeolite that increases the alkylation of benzene while reducing the amount of skeletal isomerization.
US08470725B2 Process for regenerating a catalyst
A process for regenerating one or more deactivated cobalt comprising Fischer-Tropsch catalyst particle(s), comprising the steps of: (i) oxidizing the catalyst particle(s) at a temperature between 20 and 400° C.; (ii) treating the catalyst particle(s) for more than 5 minutes with a solvent, which solvent comprises an amine, (iii) drying the catalyst particle(s); and (iv) optionally reducing the catalyst particle(s) with hydrogen or a hydrogen comprising gas. This process may be preceded by a step in which Fischer-Tropsch product is removed from the catalyst particle(s).
US08470723B2 Low softening point glass composition, bonding material using same and electronic parts
A low softening point glass composition, which is substantially free from lead, bismuth and antimony and comprises oxides of vanadium, phosphorous, tellurium and iron, a softening point of the composition being 380° C. or lower.
US08470720B2 Film forming apparatus and film forming method
A wall surface of a film forming container is heated to or above a vaporization temperature of a material monomer, which is used to form an organic film, by using an external heater formed along the wall surface of the film forming container, substrates are heated to a thermal polymerization reaction temperature by using an internal heater that is disposed apart from the external heater and near a substrate-supporting container in which the substrates are received, and the organic film is formed through thermal polymerization occurring on the substrates by supplying the material monomer into the film forming container.
US08470719B2 Method for fabricating phase change memory device using solid state reaction
Provided are a nonvolatile memory device and a method of fabricating the same, in which a phase-change layer is formed using a solid-state reaction to reduce a programmable volume, thereby lessening power consumption. The device includes a first reactant layer, a second reactant layer formed on the first reactant layer, and a phase-change layer formed between the first and second reactant layers due to a solid-state reaction between a material forming the first reactant layer and a material forming the second reactant layer. The phase-change memory device consumes low power and operates at high speed.
US08470717B2 Method of forming current tracks on semiconductors
Methods of making current tracks for semiconductors are disclosed. The methods involve selectively depositing a hot melt ink resist containing rosin resins and waxes on a silicon dioxide or silicon nitride layer coating a semiconductor followed by etching uncoated portions of the silicon dioxide or silicon nitride layer with an inorganic acid etch to expose the semiconductor and simultaneously inhibit undercutting of the hot melt ink resist. The etched portions may then be metallized to form a plurality of substantially uniform current tracks.
US08470710B2 Methods of forming a metal pattern
A method of forming a metal pattern includes depositing a metal material over a photosensitive, insulative material and into a trench positioned over a bond pad. A photoresist material having a substantially planar surface may be formed over the metal material. A portion of the photoresist material may be etched to expose the metal material outside of the trench. The metal material may be isotropically etched to leave sidewalls of the metal protruding above surfaces of the photosensitive, insulative material outside of the trench. Some methods include removing a portion of a dielectric material to form at least one trench. Metal material and photoresist material may be deposited over the trench. A portion of the photoresist material may be etched to expose areas of the metal material. The metal material may be etched to form sidewalls of the metal material that protrude above the dielectric material.
US08470708B2 Double patterning strategy for contact hole and trench in photolithography
A method of lithography patterning includes forming a mask layer on a material layer and forming a capping layer on the mask layer. The capping layer is a boron-containing layer with a higher resistance to an etching reaction of patterning process of the material layer. By adapting the boron-containing layer as the capping layer, the thickness of the mask layer can be thus reduced. Hence, a better gap filling for forming an interconnect metallization in the material layer could be achieved as well.
US08470704B2 Nonvolatile memory device and method of forming the nonvolatile memory device including giving an upper portion of an insulating layer an etching selectivity with respect to a lower portion
A nonvolatile memory device and a method of forming a nonvolatile memory device are provided. The nonvolatile memory device includes an active region of a semiconductor substrate defined by a device isolation layer, a tunnel insulating structure disposed on the active region, and a charge storage structure disposed on the tunnel insulating structure. The nonvolatile memory device also includes a gate interlayer dielectric layer disposed on the charge storage structure, and a control gate electrode disposed on the gate interlayer dielectric layer. The charge storage structure includes an upper charge storage structure and a lower charge storage structure, and the upper charge storage structure has a higher impurity concentration than the lower charge storage structure.
US08470701B2 Printable, flexible and stretchable diamond for thermal management
Various heat-sinked components and methods of making heat-sinked components are disclosed where diamond in thermal contact with one or more heat-generating components are capable of dissipating heat, thereby providing thermally-regulated components. Thermally conductive diamond is provided in patterns capable of providing efficient and maximum heat transfer away from components that may be susceptible to damage by elevated temperatures. The devices and methods are used to cool flexible electronics, integrated circuits and other complex electronics that tend to generate significant heat. Also provided are methods of making printable diamond patterns that can be used in a range of devices and device components.
US08470694B2 Apparatus and method for growing nitride semiconductor crystal film
An apparatus for growing a nitride semiconductor crystal film, comprises a chamber that can control inside temperature and air pressure, a susceptor supported by a rotating shaft inside the chamber and on which a growth substrate is placed, a reactant gas supplier that emits reactant gas to the growth substrate in parallel to a surface of the growth substrate, a first subflow gas supplier that emits first subflow gas for pressing the reactant gas down to the surface of the growth substrate at an inclination angle of 45 to 90 degrees in a same in-plane direction as the reactant gas, a second subflow gas supplier that emits second subflow gas for removing the reactant gas from an periphery of the growth substrate to the surface at an inclination angle of 45 to 90 degrees, and an exhaust device that exhausts gas from the chamber.
US08470691B2 Method for cutting substrate and method for manufacturing electronic element
An image pickup section picks up images of a pair of targets formed on a substrate with a cutting line interposed therebetween (S101). An extracting section extracts the targets from the images (S102). Then, a measuring section measures the distance d1 between the targets (S103). When a driving section presses a blade against the substrate (S104), the substrate is pressed by the blade to become warped and starts to break. Thus, the image pickup section picks up images of the targets again (S105), and the extracting section extracts the targets from the images (S106). The measuring section measures the distance d2 between the targets (S107). A determining section determines the cutting state of the substrate from the amount of change (d2−d1) of the distances between the targets (S108). Thereby, a method for cutting a substrate and a method for manufacturing electronic elements using the method are provided by which the cutting situation of the substrate can be judged at the time of cutting the substrate into chips by breaking.
US08470687B2 Strained semiconductor by full wafer bonding
One aspect of this disclosure relates to a method for forming a wafer with a strained semiconductor. In various embodiments of the method, a predetermined contour is formed in one of a semiconductor membrane and a substrate wafer. The semiconductor membrane is bonded to the substrate wafer and the predetermined contour is straightened to induce a predetermined strain in the semiconductor membrane. In various embodiments, a substrate wafer is flexed into a flexed position, a portion of the substrate wafer is bonded to a semiconductor layer when the substrate wafer is in the flexed position, and the substrate wafer is relaxed to induce a predetermined strain in the semiconductor layer. Other aspects and embodiments are provided herein.
US08470685B2 Integration of self-aligned trenches in-between metal lines
The present invention provides an improved method of forming air cavities to overcome IC via-misalignment issues. The method of forming air cavity trenches in-between metal lines of an integrated circuit includes the steps of partially removing (42) an intertrack dielectric deposited on an interconnect structure surface to control the height between the top surface of a metal line of the interconnect surface and the surface of the intertrack dielectric; depositing (44) a dielectric liner on the interconnect surface; removing (46) at least part of the dielectric liner on the interconnect surface; successively repeating (48) the deposition of the dielectric liner and the removal of the dielectric liner on the interconnect surface in so far as the interconnect surface is sufficiently protected by a remaining dielectric liner for forming of the plurality of air cavity trenches; and forming (50) at least one air cavity trench in-between the metal lines by etching the intertrack dielectric material.
US08470679B2 Semiconductor device including a deep contact and a method of manufacturing such a device
A semiconductor device includes a buried layer and a deep contact for providing a low resistive connection to the buried layer. The deep contact is formed by doped polycrystalline silicon. A method of manufacturing a semiconductor device and a deep contact for providing a low resistive connection to the buried layer, with the steps of forming a buried layer, providing an active region adjacent the buried layer and forming a deep contact for providing a low resistive connection to the buried layer by patterning a contact shape for the deep contact on an upper surface of the active region, removing part of the active region underneath the contact shape to create a deep contact cavity. Subsequently a polycrystalline silicon layer for filling the deep contact cavity is deposited and doped.
US08470675B2 Thick gate oxide for LDMOS and DEMOS
A process of forming an integrated circuit, including forming a dummy oxide layer for ion implanting low voltage transistors, replacing the dummy oxide in the low voltage transistor area with a thinner gate dielectric layer, and retaining the dummy oxide for a gate dielectric for a DEMOS or LDMOS transistor. A process of forming an integrated circuit, including forming a dummy oxide layer for ion implanting low voltage and intermediate voltage transistors, replacing the dummy oxide in the low voltage transistors with a thinner gate dielectric layer, replacing the dummy oxide in the intermediate voltage transistor with another gate dielectric layer, and retaining the dummy oxide for a gate dielectric for a DEMOS or LDMOS transistor.
US08470666B2 Methods of making random access memory devices, transistors, and memory cells
A memory device includes an array of memory cells and peripheral devices. At least some of the individual memory cells include carbonated portions that contain SiC. At least some of the peripheral devices do not include any carbonated portions. A transistor includes a first source/drain, a second source/drain, a channel including a carbonated portion of a semiconductive substrate that contains SiC between the first and second sources/drains and a gate operationally associated with opposing sides of the channel.
US08470660B2 Method of manufacturing a semiconductor device
A method of manufacturing a semiconductor device is disclosed. The exemplary method includes providing a substrate having a source region and a drain region. The method further includes forming a first recess in the substrate within the source region and a second recess in the substrate within the drain region. The first recess has a first plurality of surfaces and the second recess has a second plurality of surfaces. The method also includes epi-growing a semiconductor material in the first and second recesses and, thereafter, forming shallow isolation (STI) features in the substrate.
US08470653B2 Method for manufacturing a P-type MOS transistor, method for manufacturing a CMOS-type semiconductor apparatus having the P-type MOS transistor, and CMOS-type semiconductor apparatus manufactured using the manufacturing method
A method for manufacturing a P-type MOS transistor includes forming a gate insulating film on the substrate, forming a gate electrode from amorphous silicon containing no impurities on the gate insulating film, performing a heat treatment for controlling the film characteristics of the amorphous silicon, depositing a nickel (Ni) layer on the gate electrode, and forming nickel silicides from the gate electrode and the nickel (Ni).
US08470652B1 Monolithic integration of group III nitride enhancement layers
A monolithically integrated device includes a substrate, a first set of Group III nitride epitaxial layers grown for a first HFET on a first region of the substrate, and a second set of Group III nitride epitaxial layers for a second HFET grown on a second region of the substrate.
US08470651B2 Method for producing a thin film transistor, and a thin film transistor
Provided is a metallic wiring film which is not peeled away even when exposed to a hydrogen plasma. A metallic wiring film is constituted by an adhesion layer containing copper, Ca, and oxygen and a low-resistance metal layer (a layer of a copper alloy or pure copper) having a lower resistance than the adhesion layer. When the adhesion layer is composed of a copper alloy, which contains Ca and oxygen, and a source electrode film and a drain electrode film adhering to an ohmic contact layer are constituted by the adhesion layer, even if the adhesion layer is exposed to the hydrogen plasma, a Cu-containing oxide formed at an interface between the adhesion layer and the ohmic contact layer is not reduced, so that no peeling occurs between the adhesion layer and a silicon layer.
US08470645B2 Method for manufacturing an antifuse memory cell
A method for forming a memory cell including a selection transistor and an antifuse transistor, in a technological process adapted to the manufacturing of a first and of a second types of MOS transistors of different gate thicknesses, this method including the steps of: forming the selection transistor according to the steps of manufacturing of the N-channel transistor of the second type; and forming the antifuse transistor essentially according the steps of manufacturing of the N-channel transistor of the first type, by modifying the following step: instead of performing a P-type implantation in the channel region at the same time as in the N-channel transistors of the first type, performing an N-type implantation in the channel region at the same time as in the P-channel transistors of the first type.
US08470641B2 Exposed mold
A method for forming a semiconductor device can include providing a patterned layer of mold compound having a plurality of individual mold compound structures overlying a base film. The plurality of mold compound structures are aligned with a plurality of semiconductor dice to interpose the individual mold compound structures between the plurality of semiconductor dice. A pressure is applied to the individual mold compound structures to fill spaces between each of the plurality of semiconductor dice with the mold compound. The mold compound structures can be formed on the base film using a photosensitive mold compound. The mold compound structures can also be formed through the use of a patterned mask and a screen printing process.
US08470624B2 Fabricating method of organic electro-luminescence display unit
A fabricating method of an organic electroluminescent display unit is provided. A gate and a gate insulating layer covering the gate are formed on the substrate. A patterned metal-oxide layer with an etching stop layer thereon is formed on the gate insulating layer. A surface treatment is performed on the patterned metal-oxide layer with use of the etching stop layer as a mask, such that a portion of the patterned metal-oxide layer uncovered by the etching stop layer has greater conductivity than conductivity of another portion of the patterned metal-oxide layer covered by the etching stop layer. The patterned metal-oxide layer treated by the surface treatment includes a pixel electrode and an active layer located above the gate. A source and a drain are then formed. And then, an organic electro-luminescence layer and a top electrode are sequentially formed on the pixel electrode.
US08470623B2 Thin film display panel and method of manufacturing the same
A thin film transistor array panel includes: a substrate; a gate line disposed on the substrate and including a gate electrode; a gate insulating layer disposed on the gate line; an semiconductive oxide layer disposed on the gate insulating layer; a data line disposed on the semiconductive oxide layer and including a source electrode; a drain electrode facing the source electrode on the semiconductive oxide layer; and a passivation layer disposed on the data line. The semiconductive oxide layer is patterned with chlorine (Cl) containing gas which alters relative atomic concentrations of primary semiconductive characteristic-providing elements of the semiconductive oxide layer at least at a portion where a transistor channel region is defined.
US08470619B2 Selective decomposition of nitride semiconductors to enhance LED light extraction
A method of texturing a surface within or immediately adjacent to a template layer of a LED is described. The method uses a texturing laser directed through a substrate to decompose and pit a semiconductor material at the surface to be textured. By texturing the surface, light trapping within the template layer is reduced. Furthermore, by patterning the arrangement of pits, metal coating each pit can be arranged to spread current through the template layer and thus through the n-doped region of a LED.
US08470608B2 Combined visual/fluorescence analyte detection test
The sensitivity of visually read lateral flow immunoassay tests is enhanced by adding a small quantity of fluorescing dye or fluorescing latex bead conjugates to the initial conjugate material. When the visible spectrum test line is visibly present, the test result is observed and recorded. However, in the case where the result is indeterminate, a light of an appropriate spectrum, such as a UV, visible, or infrared spectrum, is cast on the test line to excite and fluoresce the fluorescing latex beads which are bound in the test line in true positive tests to enhance the visible color at the test line.
US08470604B2 Transient decay amperometry
A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.
US08470602B2 Methods and systems for determining the presence or amount of delta 5 steroid compounds in a sample
Disclosed are methods and systems for the analysis of delta 5 steroid compounds in a sample using supported liquid extraction and liquid chromatography/mass spectrometry.
US08470601B2 Apparatus and method for indicating biological content within a container
An apparatus for indicating biological content within a container is provided. The apparatus includes a medical sterilization container having a cover removably attached to the medical sterilization container. An enclosable, sterilizable interior compartment is formed by the medical sterilization container and the cover, wherein the interior compartment is sized to house at least one medical instrument. A biological indicator is located at least partially in communication with the interior compartment, wherein the biological indicator provides at least one indication of biological content within the interior compartment after the medical sterilization container and cover are subjected to a sterilization process.
US08470599B2 Renal progenitor cells from embryonic stem cells
The present invention relates to compositions and methods for inducing the differentiation of stem cells into renal progenitor cells. In particular, the present invention provides compositions containing activin-a, retinoic acid, and bmp-7, and variants thereof, for differentiating stem cells into renal cells containing tubular epithelia. In certain embodiments, the present invention provides stem cells cultured with compositions used to treat renal disease.
US08470598B2 Modified Vaccinia Ankara virus variant and cultivation method
The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus and the use of the virus, or its recombinants, as a medicament or vaccine. A method is provided for inducing an immune response in individuals who may be immune-compromised, receiving antiviral therapy, or have a pre-existing immunity to the vaccine virus. In addition, a method is provided for the administration of a therapeutically effective amount of the virus, or its recombinants, in a vaccinia virus prime/vaccinia virus boost innoculation regimen. The present invention relates to a method of virus amplification in primary cells which are cultivated in a serum free medium. Viruses produced by this method are advantageously free of any infectious agents comprised in animal sera.
US08470593B2 Plasmid system for multigene expression
The present invention provides a plasmid system which facilitates the construction of a single amplifiable plasmid that, having the potential to accommodate many independent expression cassettes, has the ability to express multi-subunit complex proteins such as antibodies and receptors.
US08470592B2 Isolation and characterization of Schizochytrium aggregatum cellobiohydrolase I (Cbh 1)
The present invention provides for the isolation and characterization of the cbh1 gene from Schizochytrium aggregatum. In particular, the present invention provides for the nucleic acid and amino acid sequences of Schizochytrium aggregatum cbh1, and domains, variants and derivatives thereof. The present invention further provides for the heterologous expression of Schizochytrium aggregatum Cbh1 in host cells, including yeast, e.g., Saccharomyces cerevisiae. Expression of Schizochytrium aggregatum Cbh1 in host cells will augment cellulose digestion and facilitate ethanol production by those host cells on cellulosic substrates. In certain embodiments, heterologous expression in Saccharomyces cerevisiae is in coordination with heterologous expression of other known, or newly identified saccharolytic enzymes. Therefore, the present invention also provides that the novel Schizochytrium aggregatum Cbh1 gene can utilized in a consolidated bioprocessing system.
US08470590B2 Multiwell plate device
A multiwell plate device is provided having a frame, a substantially flat substrate and a multiwell structure supported by the substrate. The multiwell structure includes multiple bottomless wells formed therein. The substrate is supported by the frame and may be processed by an automated arrayer or instrument that is used to print or spot arrays in a pattern on a reaction surface of the substrate. Thereafter, the multiwell structure may be engaged with the substrate and the multiwell structure and substrate may be engaged with the frame in an upright orientation. For scanning or other analysis, the multiwell structure and substrate may be disengaged from the frame, inverted 180°, and then reengaged with the frame in the inverted orientation.
US08470588B2 Rotatable test element
A test element and method for detecting an analyte with the aid thereof is provided. The test element is essentially disk-shaped and flat, and can be rotated about a preferably central axis which is perpendicular to the plane of the disk-shaped test element. The test element has a sample application opening for applying a liquid sample, a capillary-active zone, in particular a porous, absorbent matrix, having a first end that is remote from the axis and a second end that is near to the axis, and a sample channel which extends from an area near to the axis to the first end of the capillary-active zone that is remote from the axis.
US08470586B2 Processing polynucleotide-containing samples
Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that regain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under a second set of conditions (e.g., higher temperature and/or more basic pH). The processing region can be used to, for example, concentrate polynucleotides of a sample and/or separate inhibitors of amplification reactions from the polynucleotides. Microfluidic devices with a processing region are disclosed.
US08470583B1 Lactobacillus strain and bacteriocin
The present invention relates to an isolated Lactobacillus paracasei bacterium, deposited as NRRL B-50314, that secretes a bacteriocin. More specifically, the bacteriocin has antibacterial activity against a range of Gram-positive bacteria, including but not limited to Listeria monocytogenes, Staphylococcus aureus, Enterococcus faecalis, and other Lactobacillus species. Additionally, the bacteriocin has antibacterial activity against methicillin resistant Staphylococcus aureus.
US08470579B2 Strains of lactic acid bacteria for preventing necrotizing enterocolitis
The present invention relates to novel strains of lactic acid bacteria, Lactobacillus plantarum subsp. plantarum PM-A0087 deposited as NRRL accession number B-50523, Bifidobacterium longum PM-A0101 deposited as NRRL accession number B-50525, and Bifidobacterium bifidum PM-A0218 deposited as NRRL accession number B-50524.
US08470578B2 Purification of vaccinia viruses using hydrophobic interaction chromatography
The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in terms of purity, biological activity and stability, aspects advantageous for industrial production.
US08470576B2 Group of novel enantioselective microbial nitrile hydratases with broad substrate specificity
The present invention provides a polynucleotide or a pair of polynucleotides encoding an enzyme having nitrile hydratase (NHase) [E.C. 4.2.1.84] activity. Furthermore, a vector and a host comprising the disclosed polynucleotide or pair of polynucleotides and methods for the production of the same are provided. Moreover, the invention relates to a pair of polypeptides or a fusion protein having NHase activity, an antibody specifically binding to the pair of polypeptides or fusion protein, a primer or probe, which specifically hybridizes under stringent conditions to the disclosed polynucleotide or either one of the pair of polynucleotides, a composition comprising the polynucleotide or pair of polynucleotides, the pair of polypeptides or fusion protein, the antibody and/or one or more primers or probes of the invention and a method for the production of amides comprising the enantioselective conversion of nitriles.
US08470573B2 Hybrid polymerases having the ability to produce long amplicons
The present invention provides DNA polymerases having increased efficiency of amplification of long amplicons. The present invention also provides for methods of amplifying target nucleic acid molecules with the DNA polymerases for increasing the efficiency of amplification of long amplicons.
US08470572B2 Ketoreductase polypeptides for the production of azetidinone
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
US08470570B2 Apparatus and method for printing biomolecular droplet on substrate
An apparatus for printing a biomolecular droplet onto a substrate using an electric charge concentration effect includes; an electric field forming electrode including an accommodating area in which the biomolecular droplet including micro magnetic beads is accommodated and a nozzle formed on an end of the accommodating area through which the biomolecular droplet is discharged, a substrate disposed below the electric field forming electrode, including a grounded target surface onto which the biomolecular droplet discharged from the nozzle of the electric field forming electrode is deposited, a magnet disposed below the substrate which applies a magnetic force on the micro magnetic beads, and an open circuit type voltage applying unit electrically connected to the electric field forming electrode which applies a charge to the electric field forming electrode which generates an electrical force which causes the biomolecular droplet to be ejected onto the target surface of the substrate.
US08470568B2 Methods and compositions for producing squalene using yeast
Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically converted yeast and uses therefore. In some aspects and embodiments, the genetically converted yeast produce isoprenoids, preferably squalene. Also are provided methods of producing squalene using a genetically converted yeast or a non-genetically converted yeast. The invention also provides squalene produced by genetically converted yeast or non-genetically converted yeast.
US08470564B2 Transaminase polypeptides
The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
US08470560B2 CR-2 binding peptide P28 as molecular adjuvant for DNA vaccines
The invention is an DNA vaccine and method of use thereof for modulating the immune response against the circumsporozoite protein (CSP) of malaria parasites, using the CR2 binding motifs of C3d, especially p28.
US08470556B2 Nucleic acids that encode antigen binding proteins that bind PAR-2
The present invention provides compositions and methods relating to or derived from anti-PAR-2 antibodies. In particular embodiments, the invention provides human antibodies that bind PAR-2, PAR-2-binding fragments and derivatives of such antibodies, and PAR-2-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PAR-2-related disorders or conditions.
US08470554B2 Prokaryotic expression of soluble, active Dkk
Dickkopf (Dkk) proteins inhibit the canonical Wnt signaling pathway. Each of the members of the Dkk family has been previously cloned and expressed as a soluble protein in eukaryotic cells, while expression in bacterial cells has resulted in the formation of insoluble inclusion bodies that require further processing. The present invention provides compositions and methods for producing soluble, active dkk protein in prokaryotic host cells, by expressing the dkk protein as a fusion protein with a solubilization molecule, thereby providing an inexpensive and convenient source of pure active Dkk.
US08470550B2 Composition comprising raw starch for the production of ethanol
Disclosed herein are compositions for producing ethanol, which compositions comprise raw starch and amylase enzymes.
US08470546B2 Treatment of autism spectrum disorders with agents that activate the Locus Coeruleus-Noradrenergic system
Methods are provided for treating autism spectrum disorders (ASD) using agents that activate the locus coeruleus-noradrenergic (LC-NA) system of the brain and for screening for compounds for treating ASD comprising determining whether or not the compounds activate the LC-NA system.
US08470542B2 Methods and assays for measuring p95 and/or p95 complexes in a sample and antibodies specific for p95
The invention provides methods of measuring and/or quantifying the presence and/or amount of p95 and/or p95 complex in a sample. The invention also provides antibodies specific for p95.
US08470540B2 Method for the effective delivery of photonic energy to cultures in a fluid medium
A method of preventing bio-filming during the delivery of photonic energy to a culture or set of organisms in a fluid culture medium, the method including introducing a fluid energy-transfer medium into the fluid culture medium through an interface and distributing light into the fluid energy-transfer medium as it is introduced into the fluid culture medium.
US08470537B2 Sequential addition of short DNA oligos in DNA-polymerase-based synthesis reactions
A method of preselecting a multiplicity of DNA sequence segments that will comprise the DNA molecule of user-defined sequence, separating the DNA sequence segments temporally, and combining the multiplicity of DNA sequence segments with at least one polymerase enzyme wherein the multiplicity of DNA sequence segments join to produce the DNA molecule of user-defined sequence. Sequence segments may be of length n, where n is an odd integer. In one embodiment the length of desired hybridizing overlap is specified by the user and the sequences and the protocol for combining them are guided by computational (bioinformatics) predictions. In one embodiment sequence segments are combined from multiple reading frames to span the same region of a sequence, so that multiple desired hybridizations may occur with different overlap lengths.
US08470536B2 Compositions and method for storage of nucleic acid from bodily fluids
The present invention provides an aqueous composition and method for extracting nucleic acid from a sample of bodily fluid, such as saliva, such that the nucleic acid within said sample remains stable for at least fourteen days at room temperature. The composition permits direct use of the extracted and stored DNA in an amplification reaction without further processing.
US08470533B2 Methods and materials for assessing RNA expression
This document provides methods and materials for assessing RNA expression. For example, methods and materials for detecting the presence, absence, or amount of target nucleic acid (e.g., target RNA or target cDNA produced from target RNA), kits for detecting the presence, absence, or amount of target nucleic acid (e.g., target RNA or target cDNA produced from target RNA), and methods for making such kits are provided.
US08470531B2 Compositions, methods, and kits for amplifying nucleic acids
The present teachings are directed to compositions, methods, and kits for amplifying target nucleic acids while reducing non-specific fluorescence and undesired amplification products, sometimes referred to as secondary amplification products or spurious side-products. The enzyme inhibitors disclosed herein comprise a nucleotide sequence and at least one quencher. Complexes comprising an enzyme inhibitor associated with an enzyme, wherein at least one enzymatic activity of the enzyme is inhibited, are also provided. Methods for amplifying a target nucleic acid while reducing undesired amplification products are disclosed, as are methods for reducing non-specific fluorescence. Kits for expediting the performance of certain disclosed methods are also provided.
US08470529B2 Methine-substituted cyanine dye compounds
Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6 alkyl, sulfoalkyl, carboxyalkyl or C1-C6 alkoxy; each R2 is independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R3, R4, and R5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R3, R4 or R5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.
US08470521B2 Method for removing antiplatelet agent and anticoagulant from a platelet composition by diafiltration
The present invention relates to methods for removing antiplatelet agents and anticoagulants from a platelet preparation. In one embodiment, the method includes the step of flowing the platelet preparation through a filtering tube comprising a filtering membrane and separating the antiplatelet agents and anticoagulants from the platelet preparation by tangential flow filtration. In another embodiment, the method includes the step of passing the platelet preparation through porous material that specifically binds to the antiplatelet agents and anticoagulants.
US08470518B2 Photosensitive element having reinforcing particles and method for preparing a printing form from the element
The invention provides a photosensitive element and a method for preparing a printing form from the element. The photosensitive element includes a layer of a photosensitive composition containing a binder, a monomer, and a Norrish type II photoinitiator, wherein the photosensitive layer has a transmittance to actinic radiation of less than 20% and contains reinforcing particles of graphene and/or carbon nanotubes.
US08470517B2 Method of improving print performance in flexographic printing plates
A method of making a relief image printing element from a photosensitive printing blank is provided. A photosensitive printing blank with a laser ablatable layer disposed on at least one photocurable layer is ablated with a laser to create an in situ mask. The printing blank is then exposed to at least one source of actinic radiation through the in situ mask to selectively cross link and cure portions of the photocurable layer. Diffusion of air into the at least one photocurable layer is limited during the exposing step and preferably at least one of the type, power and incident angle of illumination of the at least one source of actinic radiation is altered during the exposure step. The resulting relief image comprises a plurality of dots and a dot shape of the plurality of dots is produced that is highly resistant to print fluting for printing on corrugated board.
US08470515B2 Method of forming an etch mask
A method of forming an etch mask includes: providing a substrate having thereon a material layer to be etched; forming a hard mask layer consisting of a radiation-sensitive, single-layer resist material on the material layer; exposing the hard mask layer to actinic energy to change solvent solubility of exposed regions of the hard mask layer; and subjecting the hard mask layer to water treatment to remove the exposed regions of the hard mask layer, thereby forming a masking pattern consisting of unexposed regions of the hard mask layer.
US08470512B2 Polymer, chemically amplified negative resist composition, and patterning process
A polymer is provided comprising recurring units having a N,N′-bis(alkoxymethyl)tetrahydropyrimidinone or N,N′-bis(hydroxymethyl)tetrahydropyrimidinone structure on a side chain. When a chemically amplified negative resist composition is formulated using the polymer and processed by lithography, a fine resist pattern can be formed with the advantages of improved LER and high resolution.
US08470510B2 Polymer for lithographic purposes and method for producing same
A polymer for lithographic purposes has at least a repeating structural unit represented by following General Formula (I). In Formula (I), R1, R3, R4, and R6 each independently represent hydrogen atom, a halogen atom, cyano group, an alkyl group, or a haloalkyl group; R2 and R5 each independently represent hydrogen atom, cyano group, etc.; X1 and X2 each independently represent single bond, or a substituted or unsubstituted bivalent alkylene, alkenylene, or cycloalkylene group, etc.; X3 and X4 each independently represent single bond or —CO—; R7, R8, R9, and R10 each independently represent hydrogen atom, an alkyl group, or a cycloalkyl group. The polymer for lithographic purposes shows good balance between line edge roughness (LER) and etching resistance and allows very fine and uniform patterning.
US08470508B2 Toner manufacturing method
Disclosed is a toner manufacturing method, comprising: dispersing a polyester resin prepared by condensing a polyol and a polycarboxylic acid into an aqueous medium and adjusting a polyester resin particle dispersion liquid, wherein the polyol includes an unsaturated polyol, or the polycarboxylic acid includes an unsaturated polycarboxylic acid; and adding a radical polymerization initiator to the polyester resin particle dispersion liquid to cause a radical polymerization reaction, and adjusting the obtained dispersion liquid of polyester resin particles.
US08470507B2 Hybrid developing carrier, hybrid developing device and image-forming apparatus
A hybrid developing carrier, comprising a resin layer formed on an outermost surface, wherein the surface of said resin layer is provided with sites formed of an inorganic compound having basic points or acidic points and sites where the resin forming the resin layer is exposed, a hybrid developing device equipped with the hybrid developing carrier, and an image-forming apparatus equipped with the hybrid developing device.
US08470506B2 Toner, and image forming method and apparatus using the toner
The toner includes at least a binder resin, and a colorant. The toner has properties such that the percentage W(3000) of components having a molecular weight of 3,000 or less in tetrahydrofuran-soluble components of the toner determined by a GPC-RALLS viscosity analysis is 20% by weight or less; the molecular weight Mp at the peak top of the main peak in the molecular weight distribution curve of the tetrahydrofuran-soluble components is from 4,000 to 10,000; and the ratio Rt(Mp)/Rs(Mp) of an inertia square radius Rt(Mp) at the molecular weight Mp to an inertia square radius Rs(Mp) of linear polystyrene at the molecular weight Mp is greater than 0.98, wherein the inertia square radius Rs(Mp) is determined from a working curve obtained by subjecting plural polystyrenes having different molecular weights to the GPC-RALLS viscosity analysis.
US08470504B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus
The electrophotographic photosensitive member contains a support; and a first intermediate layer, a second intermediate layer and a photosensitive layer which are provided on the support in this order, in which the second intermediate layer contains a polyolefin resin and a metal oxide particle having a volume-average particle diameter of 20 nm or less, and the first intermediate layer contains a metal oxide particle, and the volume-average particle diameter of the metal oxide particle contained in the first intermediate layer is 10 times or more to 200 times or less as large as the volume average particle diameter of the metal oxide particle contained in the second intermediate layer.
US08470502B2 Photosensitive resin composition, color filter and method of producing the same, and solid-state imaging device
A photosensitive resin composition is provided which provides a high resolution even when a pattern is formed using a low exposure intensity (in particular, less than 200 mJ/cm2) and may inhibit deterioration in pattern rectangularity during a post baking process of a post treatment. The photosensitive resin composition includes: a resin; an oxime photopolymerization initiator; a UV absorbing agent; and a monomer containing a hydrogen bonding group, the amount of the monomer containing a hydrogen bonding group being 30 mass % or more with respect to the total solid content of the composition, and the photosensitive resin composition is used for forming a solid-state imaging device.
US08470499B2 Method and system of fabricating alternating phase shift mask
An alternating phase shift mask is fabricated by defining transparent regions by forming light blocking patterns over a transparent substrate and forming an etch stop layer within the transparent substrate of a phase shift region among the transparent regions. The transparent substrate of the phase shift region may be etched and the etching may be deemed to be completed based upon radiation detected in an area under the etch stop layer.
US08470497B2 Manufacture of membrane electrode assembly with edge protection for PEM fuel cells
Methods for attaching a subgasket to an ionomer membrane, wherein the methods provide for the precise location of the subgasket relative to the other component edges of the fuel cell, such as the catalyst layers, so as provide the functionality required to extend the ionomer membrane life and prevent damage to the ionomer membrane during the assembly process.
US08470495B2 Electrode catalyst with improved longevity properties and fuel cell using the same
Disclosed is an electrode catalyst comprising: (a) a support; (b) metal catalyst particles supported on the support and formed of a catalytically active metal or metal-containing alloy; and (c) an anti-coarsening compound, which is dispersed in at least one region selected from the group consisting of interstitial spaces among the catalyst particles and contact sites between the support and the catalyst particles, and has a coarsening temperature higher than that of the catalyst. A method for preparing the electrode catalyst is also disclosed.
US08470493B2 Fuel cell device and system
Fuel cell devices and systems are provided. In certain embodiments, the devices include a ceramic support structure having a length, a width, and a thickness with the length direction being the dominant direction of thermal expansion. A reaction zone having at least one active layer therein is spaced from the first end and includes first and second opposing electrodes, associated active first and second gas passages, and electrolyte. The active first gas passage includes sub-passages extending in the y direction and spaced apart in the x direction. An artery flow passage extends from the first end along the length and into the reaction zone and is fluidicly coupled to the sub-passages of the active first gas passage. The thickness of the artery flow passage is greater than the thickness of the sub-passages. In other embodiments, fuel cell devices include second sub-passages for the active second gas passage and a second artery flow passage coupled thereto, and extending from either the first end or the second end into the reaction zone. In yet other embodiments, one or both electrodes of a fuel cell device are segmented.
US08470492B2 Voltage detection connector for a fuel cell and a fuel cell adapted for same
A connector of the present invention has a at least one detection terminal that is connected to an electrode provided on the fuel cell, and an insulating connector case housing the detection terminal. The connector case may have either a channel-shaped groove or a protruding guide for mating with, and for causing sliding with a protruding guide or channel-shaped groove provided on the fuel cell when the connector is attached to the fuel cell.
US08470491B2 PEM fuel cell stack hydrogen distribution insert
A fluid distribution insert adapted to be received within an inlet header of a fuel cell assembly. The fluid distribution insert includes a hollow insert with a first end and a second end. An inlet is formed at the first end of the hollow insert in fluid communication with a source of a reactant gas and adapted to receive the reactant gas therein. An outlet is formed intermediate the first end and the second end. The outlet is adapted to deliver the reactant gas to a plurality of fuel cells of the fuel cell assembly, wherein the hollow insert delivers the reactant gas to the fuel cells in a substantially simultaneous and uniform manner.
US08470488B2 Metallic bipolar plates with high electrochemical stability and improved water management
A flow field plate or bipolar plate for a fuel cell that includes a carbide coating that makes the bipolar plate conductive, hydrophilic and stable in the fuel cell environment. Suitable carbides include, but are not limited to, chromium carbide, titanium carbide, tantalum carbide, niobium carbide and zirconium carbide. The carbide coating is then polished or textured by a suitable process, such as laser or chemical etching, to provide a surface morphology that makes the coating more hydrophilic, and further reduces the contact resistance on its surface.
US08470479B2 Sensorless relative humidity control in a fuel cell application
A technique for determining the relative humidity of the cathode input airflow to a fuel cell stack that eliminates the need for a dew-point sensor. The cathode input airflow is humidified by a water vapor transfer unit that uses water in the cathode exhaust gas. The technique employs an algorithm that determines the flow of water into the cathode inlet of the stack. In one embodiment, the algorithm determines the volume flow of water through the water vapor transfer unit using the Arrhenius equation, and then converts the water volume flow to a water mole flow. The algorithm then uses the water mole flow through the water vapor transfer unit and the water mole flow of ambient air to determine the water mole flow into the cathode inlet. The algorithm then uses the water mole flow into the cathode inlet to determine the relative humidity of the cathode airflow.
US08470478B2 Solid electrolyte and electrochemical element
A solid electrolyte which is made of a material having high biocompatibility and which is capable of conducting a large electric current while performing a rectifying function; and an electrochemical element employing the same. The solid electrolyte is formed by stacking a first layer containing an acidic amino acid and a second layer containing a basic amino acid; and the electrochemical element is formed by disposing the solid electrolyte between a positive electrode and a negative electrode.
US08470469B2 Method for manufacturing a bipolar battery with a gasket
A gasket is for use in a starved electrolyte bipolar battery. The gasket may be made from a hydrophobic material in the shape of a frame to prevent the creation of an electrolyte path between adjacent cells when mounted in a battery. The frame may be designed to at least partially encompass a biplate when mounted in a bipolar battery, and include a device or way to permit gas passage through the gasket. The gasket may be made from a material with deformable properties to provide a sealing to a biplate and/or endplate when mounted in a bipolar battery, whereby an outer pressure tight seal of the battery may be obtained. A starved bipolar battery and a method for manufacturing a starved bipolar battery are also disclosed.
US08470463B2 Magnetic shield with in-plane anisotropy
An apparatus and associated method are generally directed to a magnetic shield capable of screening magnetic flux with in-plane anisotropy. Various embodiments of the present invention may have at least one magnetic shield. The shield may be constructed of a Cobalt-Iridium compound capable of providing in-plane anisotropy along a longitudinal plane of the shield.
US08470456B2 Layer system for the formation of a surface layer on a surface of a substrate and also vaporization source for the manufacture of a layer system
The invention relates to a layer system for the formation of a surface layer on a surface of a substrate, in particular on the surface of a tool, wherein the layer system includes at least one first hard layer of the composition (MoSipAYq)γ(NrCsOt)δ with (o+p+q)=γ, (r+s+t)=δ, and (γ+δ)=100, wherein 40≦γ≦60 and wherein M is at least one metal of the group of the chemical elements consisting of Al and the elements of the secondary groups IVb, Vb, VIb of the periodic system of elements. In accordance with the invention the component AY is at least one element of the group of the chemical elements consisting of Mn, Fe, Co, Ni, Cu and the elements of the secondary group IIIB and the elements of the main group IA, IIA and IIIA and the elements of the group of the lanthanoids of the periodic system of chemical elements, with AY preferably additionally containing boron.
US08470453B2 Biocompatible substrates and uses thereof
A new substrate makes it possible to modify surface properties relating to biocompatibility. Said substrate has an electron donating surface, characterized in having metal particles on said surface, said metal particles comprising palladium and at least one metal chosen from gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of said metal particles is from about 0.001 to about 8 μg/cm2. The substrate is suggested for different uses, such as for modifying the hydrophobicity, protein adsorption; tissue ingrowth, complement activation, inflammatory response, thrombogenicity, friction coefficient, and surface hardness.
US08470447B2 Easy open ends that can be favorably opened at high temperatures
An easy open end comprising a resin-coated metal plate obtained by coating a metal substrate with a polyester film via a primer, wherein the primer comprises an epoxy resin or a polyester resin and a resole-type phenol resin, and the resole-type phenol resin has 0.2 to 2.0 methylol groups per a benzene ring. The end can be lightly opened without causing defect at the time of opening the end by pushing in the end of a tab and cutting the score and, particularly, can be excellently opened at high temperatures without arousing the problem even in a state of being heated at high temperatures featuring excellent corrosion resistance, resistance against the content and retort resistance.
US08470442B2 Metal nanoparticles functionalized with rationally designed coatings and uses thereof
The present invention provides a composition and method for functionalizing nanoparticles that enables them to undergo reversible aggregation/deaggregation. The aggregation properties of this new system are reversible and readily monitored by optical absorbance measurements with the possibility of electrical and/or magnetic monitoring as well. The outer portion of the coating material is functionalized with polyethylene glycol (PEG) entities that facilitate biocompatibility and stability both in solution and in the solid state. Also provided are nanoparticles functionalized with rationally designed free radical initiators to effect tailored polymer growth from the surface. These systems may be used for a broad variety of applications, including biosensing with real-time feedback.
US08470435B2 Epdxy resin for prepreg, prepreg, fiber-reinforced composite material, and methods for production thereof
An epoxy resin composition suitably used for a prepreg which can complete curing in a short time even at a low temperature and secure a sufficient usable period under preservation at room temperature, in comparison with conventional epoxy resin compositions. An epoxy resin composition comprising at least one of an epoxy resin, an amine compound having at least one sulfur atom in the molecule thereof, and a reaction product of an epoxy resin and an amine compound having at least one sulfur atom in the molecule thereof, and an amine compound having at least one sulfur atom in the molecule thereof, and a urea compound and a dicyandiamide, wherein each of the contents of the sulfur atom and the urea compound in the epoxy resin composition is respectively 0.2 to 7% by mass and 1 to 15% by mass.
US08470433B2 Transparent decoratable multilayer film
A multi layer film which comprises the following layers: I. an upper layer composed of a polyamide molding composition which is transparent at the selected layer thickness, and II. a lower layer composed of a polyamide molding composition which comprises the following components: a) from 70 to 99% by weight of a polyamide selected from a group of polyamides and copolyamides, as described, b) from 1 to 30% by weight of a copolymer which contains units of the following monomers: α) from 20 to 94.5% by weight of one or more α-olefins having from 2 to 12 carbon atoms, β) from 5 to 79.5% by weight of one or more acrylic compounds, γ) from 0 to 50% by weight of an olefinically unsaturated epoxide, carboxylic anhydride, carboximide, oxazoline, or oxazinone, and has good printability and adhesive-bondability and transparency, and can be used, for example, as an overcoating for skis.
US08470432B2 Hardshell cover
An exemplary system, method of making, of use, for providing a hard shell cover for covering objects, boats, and like. Hard shell cover is disclosed as comprising, inter alia, a material layer 202, a material layer 204, and a material layer 206, and a transition region. Disclosed features and specifications may be variously controlled, configured, adapted or otherwise optionally modified to further improve or otherwise optimize material and design performance or other material characteristics. Exemplary embodiments of the present invention representatively provide for hard cover components, methods of making and use that may be readily incorporated with existing technologies for the improvement of covers, packaging of objects, form factors, weights and/or other manufacturing, device or material performance metrics.
US08470430B2 Honeycomb structure and method for manufacturing the same
Provided is a honeycomb structure in which as compared with partition walls of an end face side portion of all inlet of a fluid, partition walls of an end face side portion of an outlet of the fluid satisfy at least one of conditions of (1) a heat conductivity being relatively high, (2) a heat capacity being relatively large, (3) a bending strength being relatively high and (4) a porosity being relatively low. In this honeycomb structure, the melting or thermal shock breakdown of the partition walls does not easily occur, and the structure is suitably used as a DPF.
US08470429B2 Optical recording medium
An optical recording medium includes a support substrate, and a semi-transmissive recording layer including a first dielectric layer, a semi-transmissive semi-reflective layer, a second dielectric layer, a phase-change recording material layer, and a third dielectric layer which are laminated in that order from the support substrate side. The semi-transmissive semi-reflective layer is composed of silver, and the first dielectric layer includes a composite oxide layer using niobium oxide.
US08470425B2 Composite cores and panels
The plurality of pieces of low density cellular material, such as foam plastics, form a core panel having opposite side surfaces and with adjacent pieces having opposing edge surfaces extending between the side surfaces. Sheets of flexible material, such as veils or mats or scrim, are adhesively attached to the side surfaces, and portions of one sheet extend between the opposing adjacent edge surfaces for limiting flexing of the panel. The pieces may be tapered, and portions of the one sheet may project between the edge surfaces either partially or fully to form double wall webs. The webs may have flanges adhesively attached to the other sheet on the opposite side. One sheet may also be stretchable in areas not adhesively attached to the pieces to provide for curving the panel from a planar position maintained by the sheet on the opposite side.
US08470424B2 Beverage packaging labels made of resin blends that provide enhanced gas barrier properties and related methods
A method of improving the shelf life of a beverage may involve selecting a container for containing a beverage, the container having a first gas barrier property; selecting a blended label having a second gas barrier property; applying the blended label to the container such that the container has a resultant gas barrier property that is greater than the first gas barrier property; and placing the beverage in the container. A beverage container may have a PET wall having a first gas barrier property and a blended label adjacent the PET wall, the blended label having a second gas barrier property, wherein the container has a resultant gas barrier property that is greater than the first gas barrier property. Two different beverage products may be bottled in the same type of container using blended labels that have different gas barrier properties tailored for each beverage product.
US08470420B2 Heat-shrinkable film, moldings and heat-shrinkable labels made using the heat-shrinkable film, and containers made by using the moldings or fitted with the labels
A heat-shrinkable film which is excellent in mechanical characteristics such as heat shrinkage characteristics, impact resistance, and transparency and in the finish of shrinkage and which is suitable for shrink packaging, shrink bundling, shrinkable labels, and so on. A film which is made from a mixed resin comprising as the main components either a polylactic acid resin (A) and a (meth)acrylic resin (B) or a polylactic acid resin (A) and a silicone/acrylic composite rubber (D) or has at least one layer made from the mixed resin and which exhibits a heat shrinkage percentage of 20% or above in the main shrinkage direction when dipped in water at 80° C. for 10 seconds.
US08470414B2 Vehicle ornaments, kits containing the same, and methods of making and using the same
A vehicle ornament and a kit containing components to form the vehicle ornament that can be attached to an outer surface of a vehicle. The components of the kit include at least one vehicle ornament base member having a circular, substantially flat lower surface and at least one vehicle ornament upper shaped member having a three-dimensional cone-like, pyramid-like or thorn-like shape. The base member and the upper shaped member include complementary engagement members that are operatively adapted to enable non-rotatable connection of the base member to the upper shaped member. The overall height of the vehicle ornament is from about 10.2 cm to about 20.3 cm and the diameter of the circular, flat lower surface of the base member is from about 10.2 cm to about 20.3 cm.
US08470411B2 Liquid crystal alignment layer
A photopolymer mixture is capable of use for a liquid crystal alignment layer. An alignment layer is formed from such a photopolymer mixture. The mixture comprises at least two polymerisable materials which are blended together in proportion so as to give a predetermined, preferably low, surface energy. A low surface energy, e.g., less than 4×10−2 N/m, can result in an alignment layer which imparts a particular orientation to liquid crystal molecules with out requiring any post-cure treatments. The polymerisable materials may be monomers, oligomers, or diluents that form long chain molecules when cured, and the mixture may contain additives to lower the overall surface energy.
US08470410B2 Method and system for producing electrocatalytic coatings and electrodes
A method for producing nanostructured coatings on a substrate, comprising: preparing a nanocrystalline powder of a powder size comprised between 1 and 60 μm; and combining cleaning the surface of the substrate and cold spraying the nanocrystalline powder on the surface of the substrate, and a system for producing nanocrystalline coatings on a substrate, comprising a spray head, a cleaning head and a handling system monitoring the spray head and the cleaning head relative to the substrate to be coated, the spray head being a first cold spray head, the first cold spray head depositing on the substrate at least one nanocrystalline powder, the cleaning head optimizing the surface being coated with the at least one layer of nanocrystalline powder.
US08470408B2 Carbon nanotube synthesis for nanopore devices
In a process for fabricating a nanopore device, at least one carbon nanotube catalyst region is formed on a structure. A plurality of nanopores is formed in the structure at a distance from the catalyst region that is no greater than about an expected length for a carbon nanotube synthesized from the catalyst region. Then at least one carbon nanotube is synthesized from the catalyst region. This fabrication sequence enables the in situ synthesis of carbon nanotubes at the site of nanopores, whereby one or more nanotubes articulate one or more nanopores without requiring manual positioning of the nanotubes.
US08470406B2 Method of spray application, and spray apparatus, for bentonite material
The present invention provides a spray method and spray apparatus for bentonite-based material that allow forming a bentonite layer of high dry density. A spray apparatus 1 comprises a supersonic nozzle 2, to which a compressor 5 and a bentonite container 6 are connected. The supersonic nozzle 2 is fed compressed air from the compressor 5 and a bentonite-based material from the bentonite container 6. The compressed air, mixed with the bentonite-based material, is accelerated to supersonic speed when passing through a constriction portion 14 of the supersonic nozzle 2, and is sprayed at supersonic speed out of a jet orifice 11.
US08470404B2 Process of manufacturing fiber reinforced composite via selective infusion of resin and resin blocking substance
The invention relates to joined fiber reinforced composite structures with continuity of fiber reinforcement across adhesive-to-substrate boundaries. Use of a thermal gradient to control the extent of infusion of resin blocking substances into fiber reinforced material, and subsequent resin infusion and resin blocking substance removal, during manufacture of components to be subsequently bonded, provides partially exposed reinforcing fibers which serve to reinforce a subsequently formed joint or boundary.
US08470402B2 Method of depositing a metal-containing dielectric film
Methods of depositing a metal containing dielectric film on a substrate are disclosed. The metal containing dielectric film has the formula (M11-a M2a) Ob Nc, wherein 0≦a<1, 0
US08470401B2 Use of group V metal containing precursors for a process of depositing a metal containing film
The disclosure is directed to a process for depositing a group V metal containing film on a substrate by introducing a substrate into a reactor; preferably heating the substrate at a temperature above 150° C.; feeding a compound of the formula (Ia) or of the formula (Ib), or a mixture of said compounds thereof in the vapor phase into the reactor; optionally feeding a second compound of the formula (Ia) or of the formula (Ib), or a second mixture of said compounds thereof in vapor phase into the reactor; and thereby depositing the group V metal containing film onto said substrate.
US08470395B2 Low energy, high recovery, rapid cycle kinetic PSA for biogas
Disclosed herein are embodiments of a rotary gas separation device, such as a rotary pressure swing adsorption device. The rotary pressure swing device can include, for example, a rotor with a plurality of adsorber elements, a stator with a plurality of conduits, and a rotary valve comprising a seal assembly positioned between the rotor and the stator.
US08470389B2 Method of manufacturing solid electrolytic capacitor
Provided is a method of manufacturing a solid electrolytic capacitor, including the steps of: forming a capacitor element including an anode body having a dielectric coating film on a surface thereof; impregnating the capacitor element with a polymerization liquid containing a precursor monomer of a conductive polymer and an oxidant; impregnating the capacitor element impregnated with the polymerization liquid with a silane compound or a silane compound containing solution; and forming a conductive polymer layer by polymerizing the precursor monomer after impregnating the capacitor element with the silane compound or the silane compound containing solution.
US08470387B2 Bone repair material and method for producing the same
A bone repair material being superior in apatite-forming ability and its stability in a storage and high in scratch resistance is disclosed. The material is produced by a method comprising the steps of: immersing a substrate made of titanium or a titanium alloy in a first aqueous solution that does not contain calcium ions but contains at least one cation selected from the group consisting of sodium ions and potassium ions and is alkaline; immersing the substrate in a second aqueous solution that does not contain phosphate ions but contains calcium ions; heating the substrate in a dry atmosphere; and treating the substrate with hot water of 60° C. or higher or with steam.
US08470384B2 Oxalamide derivative as umami flavouring agent
The compound of the formula (1) is novel and is useful in conferring umami taste on consumable compositions, such as foodstuffs and beverages.
US08470383B2 Method and system for treating food items with an additive and liquid nitrogen
A liquid additive is sprayed over liquid nitrogen to form discrete solid particles of the additive in liquid nitrogen. The mixture of additive particles and liquid nitrogen is mixed with a flow of liquid nitrogen at an eductor pump to provide a food treatment composition comprising additive particles. The food treatment composition flows into an interior of food processing equipment to come into contact with food items contained therein.
US08470377B2 Composition and method for reducing food intake
The present invention features compositions and methods for suppressing appetite. The compositions of the invention are composed of a dietary fiber and a combination of selected herbal extracts, at least one of which is capable of inhibiting gastric emptying and one which increases metabolic rate.
US08470376B2 NFAT signal inhibitor and calcineurin inhibitor
To provide a drug, an external use composition, and a cosmetic composition, which exhibit an NFAT signal inhibitory action, a calcineurin inhibitory action, and a hair growth-promoting effect.The NFAT signal inhibitor contains, as an active ingredient, American angelica or an extract thereof.
US08470375B1 Method of formulating and designing liquid drug suspensions containing ion exchange resin particles
The invention relates to the formulation and quality control of liquid drug suspensions. In particular, the invention relates to methods of formulating liquid suspensions comprising drug-containing resin particles. The invention also relates to methods of confirming the acceptability of drug-containing resin particles for use in formulating liquid drug suspensions. The invention further relates to methods of formulating liquid suspensions in which drug-containing resin particles, the liquid suspension, or both are modified to achieve a desired in vitro dissolution profile. The invention also relates to a novel dissolution method and methods of predicting in vivo bioequivalence based on in vitro dissolution methods.
US08470372B2 Material with immunogenicity
Provided is a fusion protein, which comprises human papillomavirus E7 antigen, virus capsid protein and molecular chaperone. Also provided is a macromolecule with immunogenicity aggregated by the fusion proteins. The particle morphology of the macromolecule is different from that of the virus-like particle. The macromolecule can be used for treatment of human papillomavirus relating diseases.
US08470369B2 Bone paste composition
Bone paste compositions are described, which promote bone healing and remodeling by stimulating bone marrow elements using a combination of hemopoietic agents, angiogenic agents and a bone molecular signaling material.
US08470368B2 Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a thiazolidinedione derivative is herein disclosed and described.
US08470353B2 Two-piece, internal-channel osmotic delivery system flow modulator
An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
US08470350B2 Cosmetic compositions and container therefor
A self-standing container holds particles of a cosmetic composition. The container may be cup-shaped or box-shaped, for example, and made of laminated paper or polystyrene. When ready to use, the user opens the container and adds liquid or gel to mix with the dry particles to form a moist cosmetic composition, so no separate mixing container or measuring cup is necessary. The composition formed is suitable for treating a user's skin and/or hair. A fill mark on the container informs the user of a proper amount of the liquid or gel to add to the container. The particles may include both ground-up and whole particles from substances such as dried botanicals (plant ingredients) and a binding agent. A cosmetic composition includes a ready-to-mix mixture of ingredients including particles from dried herbs and/or flowers and a dried food, and an essential oil.
US08470347B2 Self-emulsifying active substance formulation and use of this formulation
The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.
US08470344B2 Aqueous dispersions and solutions of difficult to dissolve materials and methods of their preparation
The present invention encompasses a method of preparing a ready-to-dissolve or ready-to-disperse composition of difficult to dissolve in water compounds and suspensions or aqueous solutions of difficult to dissolve in water compounds.
US08470342B2 Methods of altering an immune response induced by CpG oligodeoxynucleotides
It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune response are disclosed that include administering agents that increase the activity and/or expression of CXCL16 and a D ODN. Methods of decreasing an immune response to a CpG ODN are also disclosed. These methods include administering an agent that decreases the activity and/or expression of CXCL16. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression of CXCL16 are provided.
US08470336B2 Vaccination of young animals against Lawsonia intracellularis infections
The present invention provides a method of vaccinating a young animal against L. intracellularis infection comprising the step of administering to an animal an effective dose of L. intracellularis antigen. It also provides a method of vaccinating an animal, preferably a young animal, having anti-L. intracellularis antibodies or is exposed to anti-L. intracellularis antibodies. In particular, those anti-L.intracellularis antibodies are maternally derived antibodies.
US08470335B2 Recombinant SARS-CoV nsp12 and the use of thereof and the method for producing it
The present invention relates to a recombinant severe acute respiratory syndrome coronavirus (SARS-CoV) non-structural protein (nsp) 12 with an RNA polymerase activity, its expression vector, its preparation method, and its use. According to the present invention, a soluble recombinant SARS-CoV nsp12 with an RdRp activity of initiating SARS-CoV genome synthesis can be over-expressed in the transformed host cells, and conveniently purified with high purity. An in vitro replication system important for studying SARS-CoV replication can be established with the purified recombinant SARS-CoV nsp12. SARS-CoV nsp12 produced by the present invention can also be used as a target for the development of anti-viral agents against SARS-CoV. In addition, materials inhibiting RNA-dependent RNA polymerase (RdRp) activity of nsp12 can be screened efficiently according to the present invention as the optimal conditions for the RdRp assay with SARS-CoV nsp12 were found.
US08470333B2 Chimeric peptides comprising HER-2 B-cell epitopes and T-helper epitopes
Compositions, methods, and vaccines that may stimulate the immune system and that may be used for treating malignancies associated with overexpression of the HER-2 protein are provided. Such compositions include epitopes of the HER-2 proteins.
US08470331B2 Composition of antigen and glycolipid adjuvant for sublingual administration
A method of producing a mucosal and systemic immune response in a mammal comprising administering sublingually an effective amount of a composition comprising at least one antigen and a glycolipid adjuvant to said mammal.
US08470328B2 Purification method which prevents denaturation of an antibody
The present invention provides a method of purifying an antibody by protein A affinity chromatography. More specifically, the present invention provides a technique relating to an elution buffer solution which provides a good antibody recovery rate without denaturation.
US08470327B2 Human binding molecules capable of neutralizing influenza virus H3N2 and uses thereof
Binding molecules, such as human monoclonal antibodies, that bind to influenza virus comprising HA of the H3 subtype, such as H3N2, and have a broad neutralizing activity against such influenza virus. Provided are nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H3N2 infection. The antibodies may provide cross-subtype protection, such that infections with H3, H7, and/or H10-based influenza subtypes can be prevented and/or treated.
US08470325B2 Method of treating amykloidosis comprising administering an anti-HMGB-1 antibody
Previously, it was difficult to obtain high-affinity antibodies that specifically bind to HMGB-1 but not to HMGB-2. Under this circumstance, the present inventors successfully obtained antibodies that are more reactive to HMGB-1 than to HMGB-2 by using specific peptides as an antigen. The present inventors also demonstrated that the antibodies had a HMGB-1-neutralizing activity. The present inventors administered the antibodies to amyloidosis model animals, and as a result, successfully demonstrated that the antibodies produced a significant therapeutic effect.
US08470322B2 Anti sulfatides and anti sufated proteoglycans antibodies and their use
The present invention relates to the biotechnology and particularly with new products for use in human health.The present invention provides new specific monoclonal antibodies, which bind with high affinity sulfatides and sulfated proteoglycans.The anti sulfatides and anti sulfated proteoglycans antibodies disclosed in the present invention and described in the description, provide important diagnostic and therapeutic tools to act on pathological processes associated with the appearance of atherosclerotic plaques.Accordingly, the invention provides pharmaceutical compositions comprising MAbs of the invention or fragments thereof for the therapeutic and diagnostic use associated with cardiovascular diseases. Particularly, the present invention relates to the fragments derived from the MAbs that recognize sulfatides and sulfated proteoglycans, which can be used in the therapy or diagnosis of this pathology.
US08470320B2 Humanised antibodies with anti-tumour activity
The present invention provides humanized antibodies and binding domains thereof with anti-tumor activity. In particular the humanized antibodies have specific binding to and direct killing of human colon tumor cells and display potent immune-mediated cytotoxic activity against human colon cancer cells in vitro using antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) assays and in vivo using mouse tumor models.
US08470317B2 B7RP-1 antagonists
Novel polypeptides which comprise a receptor-ligand pair involved in T-cell, activation are disclosed. Nucleic acid molecules encoding said polypeptides, and vectors and host cells for expressing same are also disclosed. The polypeptides, or agonists and antagonists thereof, are used to treat T-cell mediated disorders.
US08470316B2 Agents for suppressing damage to transplanted islets after islet transplantation
The present inventors investigated anti-IL-6 receptor antibodies for their effect in suppressing damage to transplanted islets after islet transplantation. As a result, they found that anti-IL-6 receptor antibodies reduced damage to transplanted islets, improved islet survival, and corrected hyperglycemia in recipients. Further, they revealed that administration of the anti-IL-6 receptor antibodies of the present invention suppressed the production of inflammatory cytokines by infiltrating cells after transplantation. Specifically, the present inventors discovered for the first time that damage to transplanted islets after islet transplantation can be suppressed by using anti-IL-6 receptor antibodies according to the present invention.
US08470307B2 Methods for treating acute myeloid leukemia with diphtheria toxin-interleukin-3 conjugates
The present invention provides methods for inhibiting interleukin-3 receptor-expressing cells, and, in particular, inhibiting the growth of such cells by using a diphtheria toxin-human interleukin-3 conjugate (DT-IL3) that is toxic to cells expressing the interleukin-3 receptor. In preferred embodiments, the DT-IL3 conjugate is a fusion protein comprising amino acids 1-388 of diphtheria toxin fused via a peptide linker to full-length, human interleukin-3. In certain embodiments, the methods of the present invention relate to the administration of a DT-IL3 conjugate to inhibit the growth of cancer cells and/or cancer stem cells in humans, which cells express one or more subunits of the interleukin-3 receptor. Exemplary cells include myeloid leukemia cancer stem cells. In other embodiments, the methods of the present invention relate to ex vivo purging of bone marrow or peripheral blood to remove cells that express one or more subunits of the interleukin-3 receptor such that the purged bone marrow or peripheral blood is suitable, e.g., for autologous stem cell transplantation to restore hematopoietic function.
US08470304B2 Therapeutic vitamin D sun-protecting formulations and methods for their use
The present invention concerns topical sun-protecting formulations including therapeutically effective amounts of Vitamin D, including formulations that provide Vitamin D in bioavailable amounts that correspond to decreased natural Vitamin D production resulting from the sun-blocking effects of the formulations and formulations for the prevention and treatment of disorders and disease states associated with vitamin D deficiency and vitamin D insufficiency.
US08470302B2 Toothpaste
A toothpaste filled in a container which has two chambers and is capable of simultaneously discharging two different compositions filled respectively in the two chambers when the main body of the container is pressed, wherein a ratio of a storage modulus GA′ of Composition (A) filled in one chamber to a storage modulus GB′ of Composition (B) filled in the other chamber falls within a range of from 0.6 to 1.4. By controlling the ratio, it is possible to stably discharge from the container storing these two compositions separately predetermined amounts of these two compositions which will otherwise cause a time-dependent change if they are pre-mixed thereby failing to attain the purpose of their addition.
US08470300B2 Coated sensors and methods related thereto
The invention provides coated sensors for detecting the presence of analytes. The sensor comprises one or more fluorescent sources, such as one or more quantum dots or one or more fluorescent dyes, a polymeric matrix, a surface coating, and one or more analyte sensing components. The surface coating may be a conformal polymeric film, permeable to the analyte, which may be deposited via a solventless process such as initiated chemical vapor deposition or photoinitiated chemical vapor deposition. The surface coating may increase the biocompatibility of the sensor, reduce nonspecific protein adsorption, and/or sequester functional sensor components within the sensor. The invention also provides methods for detecting the presence of an analyte with coated sensors of the invention.
US08470297B1 FDG-pet evaluation of Ewing's sarcoma sensitivity
This invention relates to methods for evaluating the efficacy of an IGF1R inhibitor, such as an anti-IGF1R antibody, for the treatment of an Ewing's sarcoma tumor by determining the level of tumoral glucose metabolism. Tumoral glucose metabolism is determining at an early point in the treatment regimen by any of several methods known in the art including FDG-PET/CT scan.
US08470295B2 Methods of treatment of androgenic steroidal hormone dependent cancer with auger electron-emitting nucleoside analogs
A method is provided for treatment of disorders involving hyperproliferative cells, such as malignancies, advanced stage solid tumors like glioblastoma multiforme, and non-malignant hyperproliferative pathological conditions such as adult macular degeneration. A short range, unselective cell killing radiotherapeutic substance is administered, optionally in a spatially defined volume of tissue, optionally in combination with a mitogenic agent that stimulates or induces DNA biosynthesis. In this way, the percentage of hyperproliferative that are susceptible to killing by the radiotherapeutic agent is increased. Cancer stem cells can be induced to enter S phase with the mitogenic agent, then killed with the radiotherapeutic agent. Thus, not only does the combination effectively kill the transit amplifying cell population, the most rapidly replicating type of cell in a tumor, but it also effectively kills the tumor stem cells, which give rise to the transit amplifying cells, for a longer lasting anticancer effect.
US08470287B2 Preparation of copper zinc tin sulfide
The present invention relates to synthesis of copper zinc tin sulfide, Cu2ZnSnS4. Copper zinc tin sulfide is useful as an absorber material in a thin film solar cell application.
US08470282B2 Production of calcium carbonate
A method of producing calcium carbonate from lime comprises the steps of: (i) providing an aqueous solution comprising 10% to 35% by weight of dissolved polyhydroxy compound and 1% to 5% by weight of dissolved calcium hydroxide (expressed as Ca(OH)2) and having a pH of at least 11.5; (ii) treating the solution prepared in step (i) to remove solids including suspended solids; (iii) dispersing carbon dioxide through the solution so as to form calcium carbonate with a consequential reduction in the pH of the reaction mixture, (iv) during a time period beginning at the start of a sudden, short rise in pH and ended during a subsequent fall in pH but before it reaches 9.5 terminating the dispersion of carbon dioxide and adding an alkaline reagent to maintain a pH for the product mixture of at least 9.5, and (v) recovering precipitated calcium carbonate.
US08470279B2 High purity silicon-containing products and method of manufacture
Silicon-containing products, such as silicon, silicon carbide and silicon nitride, containing less than 0.01 weight percent total mineral impurities and selectively determined carbon-to-silicon ratios. The products are derived from plant matter, such as rice hulls and rice straw, containing at least three weight percent silica. Methods are provided for making such high purity silicon-containing products by leaching silica-containing plant matter with aqueous sulfuric acid under controlled temperatures, pressures and reaction times to remove minerals and metals while adjusting the mole ratio of fixed carbon to silica, and then thermally treating under controlled conditions to produce the desired product.
US08470276B1 Process for CO2 capture using a regenerable magnesium hydroxide sorbent
A process for CO2 separation using a regenerable Mg(OH)2 sorbent. The process absorbs CO2 through the formation of MgCO3 and releases water product H2O. The MgCO3 is partially regenerated through direct contact with steam, which acts to heat the magnesium carbonate to a higher temperature, provide heat duty required to decompose the magnesium carbonate to yield MgO and CO2, provide an H2O environment over the magnesium carbonate thereby shifting the equilibrium and increasing the potential for CO2 desorption, and supply H2O for rehydroxylation of a portion of the MgO. The mixture is polished in the absence of CO2 using water product H2O produced during the CO2 absorption to maintain sorbent capture capacity. The sorbent now comprised substantially of Mg(OH)2 is then available for further CO2 absorption duty in a cyclic process.
US08470275B2 Reduced-carbon footprint concrete compositions
Reduced-carbon footprint concrete compositions, and methods for making and using the same, are provided. Aspects of the reduced-carbon footprint concrete compositions include CO2-sequestering carbonate compounds, which may be present in the hydraulic cement and/or aggregate components of the concrete. The reduced-carbon footprint concrete compositions find use in a variety of applications, including use in a variety of building materials and building applications.
US08470273B2 Device and method for processing cement kiln combustion exhaust
A combustion exhaust gas processing device comprises: a dust collector collecting dust in a cement kiln combustion exhaust gas: a wet dust collector as a catalyst-poisoning-substance stripper removing a catalyst-poisoning substance from a combustion exhaust gas which passed the wet dust collector; and a catalyst device from which NOx, a persistent organic pollutant, etc. in the preheated combustion exhaust gas, are removed. A titanium-vanadium catalyst etc. as an oxide catalyst is used upstream of the catalyst device, and a platinum catalyst etc. as a noble-metal catalyst downstream of the catalyst device. The temperature of the combustion exhaust gas after the catalyst-poisoning substance is removed is increased up to 140° C. or more with the preheaters to prevent decline in denitration efficiency of and the decomposition efficiency of a volatile organic compound.
US08470271B2 Process for chlorinating resources containing recoverable metals
A process for chlorinating ore, slag, mill scale, scrap, dust and other resources containing recoverable metals from the groups 4-6, 8-12, and 14 in the periodic table. The process comprises: a) forming a liquid fused salt melt consisting essentially of aluminum chloride and at least one other metal chloride selected from the group consisting of alkali metal chlorides and alkaline earth metal chlorides, wherein the aluminum chloride content in the liquid salt melt exceeds 10% by weight; b) introducing the recoverable metal resources into said liquid salt melt: c) reacting the aluminum chloride as chlorine donor with said recoverable metal resource to form metal chlorides, which are dissolved in the salt melt; and d) recovering the formed metal chlorides from the salt melt.
US08470269B2 Highly efficient uranium leaching method using ultrasound
A highly efficient uranium leaching method using ultrasound is disclosed. The uranium leaching method includes preparing black slate powder containing uranium by pulverizing black slate containing uranium, placing the black slate powder and water in a reaction bath, and performing uranium leaching by adding and mixing sulfuric acid and an oxidant with the black slate powder and water to prepare a mixture in the reaction bath while applying ultrasound to the reaction bath. In this method, uranium leaching efficiency can be maximized by adding sulfuric acid to the uranium ore while applying ultrasound thereto.
US08470267B2 Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus
An apparatus for separating magnetic particles from a liquid which contains said particles, said liquid being contained in an elongated vessel (11) having a length axis (12), said vessel being arranged in a vessel holder (13) with its length axis (12) in a substantially vertical position, said vessel (11) having a bottom and a tapered cross-section that diminishes towards the bottom of the vessel and a side wall (14) which has an outer surface which forms an angle with the length axis (12) of said vessel (11). This apparatus comprises a magnet (15) having a plane outer surface (16) and being adapted for being moved by transport means (17) along a motion path (25), said magnet (15) and said transport means (17) being so arranged with respect to said vessel (11) that over a portion of said motion path (25) said plane outer surface (16) of said magnet is in contact with a portion of said outer surface of said side wall (14) of said vessel (11), and transport means (17) for moving said magnet (15) between a first predetermined position and a second predetermined position along said motion path (25).
US08470266B2 Sample packing device
Provided is a sample packing device for packing a sample with respect to a microchip for performing reaction of a micro component contained in the sample, the microchip at least including: a sample reservoir; a reaction reservoir; and a channel connected between the sample reservoir and the reaction reservoir, in which a package including a sample chamber packed in advance with the sample is mounted on the microchip so as to pack the sample in the sample chamber into the sample reservoir.
US08470262B2 Microfluidic device
It is a microfluidic device including a flowchannel in which liquid flows. The flowchannel includes a main channel and a pair of branch channels provided across the main channel from each other to be each connected to the main channel. The main channel includes a first zone, a second zone, and a coupling zone that connects the first zone and the second zone. The second zone is smaller than the first zone in a distance between a bottom surface and a ceiling surface. The coupling zone is configured such that the distance between the bottom surface and the ceiling surface thereof gradually decreases towards the second zone from the first zone. A connection zone provided in the main channel and connected to each of the pair of branch channels overlaps with the coupling zone.
US08470261B2 Integrated sample preparation systems and stabilized enzyme mixtures
The present invention provides integrated sample preparation systems and stabilized enzyme mixtures. In particular, the present invention provides microfluidic cards configured for processing a sample and generating DNA libraries that are suitable for use in sequencing methods or other suitable nucleic acid analysis methods. The present invention also provides stabilized enzyme mixtures containing an enzyme, BSA, and a sugar. Such enzyme mixtures may be lyophilized and stored at room temperature without significant loss of enzyme activity for months.
US08470256B2 Device for sorting carbon nanotubes
A method for sorting carbon nanotubes (CNTs) is disclosed. In one embodiment, a method for sorting CNTs of the present disclosure comprises providing to a surface of a substrate, the surface modified with a trans isomer of photo-isomerization-reactive diazo compound, a dispersion containing a mixture of conducting CNTs and semiconducting CNTs; removing CNTs which are not associated with the modified surface from the surface; and irradiating the modified surface to detach the CNTs associated with the modified surface.
US08470248B2 Gas identifying apparatus, gas identifying method gas handling assisting system and gas handling assisting method for identifying gas based on color of reaction surface produced by chemical reaction
A detector detects the color of a medium after a gas to be identified and a reagent have chemically reacted with each other on the medium. A controller identifies color information, which is most similar to the color detected by the detector, from color information stored in a spectral database, and reads gas identifying information related to the identified color information, as gas identifying information representing the gas to be identified, from the spectral database.
US08470246B2 Detection and fluidic system of a flow cytometer
The fluidic system including a sheath pump that pumps sheath fluid from a sheath container into an interrogation zone, a waste pump that pumps waste fluid from the interrogation zone to a waste container, in which the flow rate of the sheath fluid is different from the flow rate of the waste fluid thereby drawing a sample fluid from a sample container into the interrogation zone, a detection system that provides a data set of input signals from the sample fluid, an analysis engine that recognizes aggregate particle events in the data set, and a controller that automatically adjusts the flow rate of the sample fluid into the interrogation zone based on the recognition of aggregate particle events, by controlling at least one of the flow rates of the sheath fluid and the waste fluid.
US08470245B2 Plastic reprocessing with controlled decontamination
A device for reprocessing used plastic containers including a system for analyzing the degree of contamination of the plastic, a system for determining decontamination process parameters as a function of the degree of contamination thus detected, and a system for controlled decontamination of the plastic according to the decontamination process parameters thus determined. The system for determining decontamination process parameters provides determined decontamination process parameters to corresponding decontamination control elements that are automatically adjusted depending on the degree of contamination.
US08470244B2 Receiving and transferring station for coverslipped specimen slides
A receiving and transferring station (1) for coverslipped specimen slides (2, 2′, 2″) comprises at least one vertically upright magazine frame (5), open toward the receiving side, for at least one specimen slide magazine (4) having horizontally oriented compartments (6), and a rotation apparatus, connected to the magazine frame (5) and having a vertically upright rotation axis, for conveying the magazine frame (5) from a receiving position (3) into a transferring position (8).
US08470243B2 Sample plate for a biochemical analyzer
A sample plate for a biochemical analyzer is provided, which includes a main shaft, an inner plate, an outer plate, a refrigeration bin, a tubing portion, a cooling fluid inlet and a cooling fluid outlet.
US08470241B2 Fluid injection and safety system
Various medical systems and methods are described, including a medical monitoring system. The medical monitoring system can have a fluid system configured to receive bodily fluid and optically analyze said fluid to determine analyte concentration. The fluid system can have a removable portion. The removable portion can have an opening with a port. The system can also have a container configured to contain anticoagulant. The container can have a portion configured to mate with the port of the removable portion. The container can be further configured to not fit into a conventional luer fitting. An anti-coagulant insertion apparatus is also described. The apparatus can have a syringe, a dock with a port, and an adapter configured to connect the syringe to the port. The dock can also have a tab configured to move with the port.
US08470240B2 Method and device for sterilizing preforms
The method includes at least the following steps of spraying a flow of sterilizing vapor, including a vaporized sterilizing product, towards the preforms to be sterilized, so as to cover at least an inner wall (15) of the preforms to be sterilized with the product; and heating, by radiation, the preforms covered with sterilizing product in order to bring them to a temperature (T2) at or above an activation temperature (Ta) for the product. The spraying of the flow of sterilizing vapor is carried out in a protective chamber (40), heating is carried out outside the protective chamber (40), and the flow of sterilizing vapor is in the form of a jet of vapor (F) vaporized onto the preforms (12), in such a way as to bring about the deposition, by condensation, of a substantially uniform film of condensate (48) of sterilizing product on at least the inner wall (15) of the preforms to be sterilized.
US08470239B1 Sanitization devices and methods of their use
The present invention relates to sanitization devices and methods. More particularly, the invention relates to devices and methods that significantly reduce or eliminate germs, bacteria and/or other microorganisms from objects such as bags, purses, footwear or other objects, as well as bare feet, hands, paws, hooves or other anatomical surfaces, which come into contact with them. The device and method uses germicidal radiation which exposes only the areas of the object that come into applied contact with the device. A top platform of the device is partitioned so that each partition can act independently of each other.
US08470238B2 Composition and method for controlling copper discharge and erosion of copper alloys in industrial systems
Compositions and methods of using such compositions for reducing copper ion discharge from aqueous systems is disclosed and claimed. The composition includes a synergistic combination of at least two different benzotriazoles or salts thereof that effectively provides an erosion-resistant barrier on copper-containing surfaces of industrial systems.
US08470232B2 Annular belt made of polyimide and a production method thereof
The present invention relates to a method for producing an annular belt made of polyimide comprising; a) joining both ends of a sheet made of a polyimide precursor to form an annular belt; and b) performing an imidizing reaction of the polyimide precursor.
US08470230B2 Method for forming a container and cap assembly
A container and cap assembly includes a container body and a cap integrally connected to the container body. An annular recess is formed in the lip of the container. The cap includes first and second sealing flanges that form a generally fluid tight seal with an annular lip of the container body.
US08470228B2 Method and a device for injection moulding and assembling plastic parts
The invention concerns a device for injection molding (1) comprising a first fixed half-mold (3) and a second half-mold (5) mobile in direction (y) of the side blocks (4) of an injection molding machine (2). Between the first and the second half-molds are mounted first and second immediate elements (6, 7) mobile in the direction of the side blocks (4). The first and the second intermediate elements (6, 7) comprise each a mold support (12, 13) pivoting relative to a base (14, 15, 31, 32) about a pivoting axis (8, 9). Centering elements (26, 27) upon the opening and closure of the injection molding devices (1).
US08470226B2 Creating conduit end caps in the field
A method for forming an end cap includes cleaning an exposed end of a conduit upon which the end cap will be formed, inserting a backing material into the exposed end of the conduit to the desired resin depth, dispensing the resin into the conduit, spreading the resin across the backing material, curing the resin with a radiation source and applying additional layers of resin and curing until the resin is flush with or forms a convex surface relative to an exposed end of the conduit.
US08470225B2 Tray or storage/transport-box floor
A transport/storage tray is made by injecting molding of plastic an upper floor panel formed with an array of throughgoing holes and a separate lower floor panel with an array of throughgoing holes. Then the upper and lower panels are juxtaposed with each of the holes of the upper panel aligned with a respective one of the holes of the lower panel, and the two panels are welded together.
US08470224B2 Method of manufacturing sheet for food containers
This invention relates to a method of manufacturing sheet for food containers, which comprises: adding a chain extender to moist flakes of recovered PET; charging the flakes of recovered PET containing the chain extender into an extruder having two or more vent holes, melting and kneading the flakes of recovered PET with sucking to degas through the vent holes, while molecular chains of the recovered PET of which the molecular weight has been lowered are bonded to each other by the chain extender to render the molecular weight higher, and simultaneously, ethylene glycol and acetaldehyde, produced during depolymerization by water and heat, are trapped by the chain extender to remove residual aldehydes; and extruding the recovered PET from the extruder into sheet.
US08470222B2 Fibers formed from a blend of a modified aliphatic-aromatic copolyester and thermoplastic starch
A fiber formed from a thermoplastic composition that contains a thermoplastic starch and an aliphatic-aromatic copolyester is provided. The copolyester enhances the strength of the starch-containing fibers and also facilitates the ability of the starch to be melt processed. Due to its relatively low melting point, the aliphatic-aromatic copolyester may also be extruded with the thermoplastic starch at a temperature that is low enough to avoid substantial removal of the moisture found in the starch. Furthermore, the aliphatic-aromatic copolyester is also modified with an alcohol so that it contains one or more hydroxyalkyl or alkyl terminal groups. By selectively controlling the conditions of the alcoholysis reaction (e.g., alcohol and copolymer concentrations, temperature, etc.), the resulting modified aliphatic-aromatic copolyester may have a molecular weight that is relatively low. Such low molecular weight polymers have the combination of a higher melt flow index and lower apparent viscosity, which is useful in a wide variety of fiber forming applications, such as in the meltblowing of nonwoven webs.
US08470221B2 Method for making carbon nanotube composite wire structure
A method for making a carbon nanotube composite wire structure comprises the following steps. A supply unit, a collecting unit, and a wrapping unit are provided. The wrapping unit comprises a hollow rotating shaft, and a face plate mounted on the hollow rotating shaft. A linear structure is provided by the supply unit. The linear structure passes through the hollow rotating shaft and is fixed on a collecting unit. A carbon nanotube structure is drawn from a carbon nanotube array. The carbon nanotube array is loaded on the face plate. One end of the carbon nanotube structure is adhered to the linear structure. The face plate is rotated, and the linear structure is pulled along a fixed direction. As such the carbon nanotube structure is wrapping around the linear structure.
US08470217B2 Foamed molding and its manufacturing method
After heating the expandable resin beads to sealing temperature of expandable resin beads in the presence of heated steam, foam cells are sealed and cooled while controlling the foaming amount. The foaming amount is controlled by pressure control on the expandable resin beads in the mold. Mutually adjacent foam cells are softened, fused, and bonded on contact faces, and thereby a foamed molding is manufactured. This foamed molding is characterized by three-dimensional permeable pores of volume porosity of 10 to 40% among foam cells, having bending limit strength of at least 10N. Without using adhesive resin, a foamed molding having enough strength and desired porous structure is obtained.
US08470216B2 Method for producing a composite material with improved adhesion between thermoplastics and polyurethane
The present disclosure relates to a method for producing composite materials containing as a first layer a foamed thermoplastic support and as a second layer polyurethane (PU), the resulting composite materials being characterized by improved foam adhesion, wherein (i) a foamed polycarbonate molding composition is produced by injection molding using chemical or physical foaming techniques, and (ii) the polyurethane reaction system is applied on top and allowed to cure. The disclosure also provides the composite systems produced by this method and their use as a component, in particular in the automotive sector.
US08470212B2 Infrared shielding nanoparticle, its manufacturing method, infrared shielding nanoparticle dispersion using the same, and infrared shielding base material
There is provided infrared shielding nanoparticles having excellent water-resistant property and excellent infrared shielding property, which is the infrared shielding nanoparticles of composite tungsten oxide expressed by a general formula WyOz and/or a general formula MxWyOz, with an average primary particle size of the nanoparticle being 1 nm or more and 800 nm or less, and a surface of the nanoparticle being coated with tetrafunctional silane compound or its hydrolysis product and/or an organic metal compound.
US08470210B2 Carbon blacks-free sulfur-vulcanised electrically conductive rubber blends
A practical and environmentally-friendly method, i.e. the high temperature-mechanical mixing by using an internal mixing device and a two-roll open milling device is used to produce the carbon blacks-free electrically conductive sulfur-vulcanised rubber blends of solid poly(butadiene-co-acrylonitrile) and solid sulfonic acid doped polyaniline. The addition of sulfur vulcanisation system does not affect the electrical properties of the vulcanised blends. All vulcanised blends prepared by using this method show useful electrical conductivities up to the order of 10−2 S/cm, good tensile strengths up to 18.0 MPa and colourable with the addition of a whitening agent. As a result, they have good potential to be used for manufacturing any antistatic products, electrostatic discharge or dissipative products and electromagnetic or radio frequency interferences shielding products.
US08470205B2 Electrically conductive films formed from dispersions comprising conductive polymers and hyperbranched polymers
An aqueous dispersion and a method for making an aqueous dispersion. The dispersion including at least one conductive polymer, such as a polythienothiophene, at least one hyperbranched polymer and optionally at least one colloid-forming polymeric acid and one non-fluorinated polymeric acid. Devices utilizing layers formed of the aqueous dispersions are also disclosed.
US08470203B2 Fabrication of polyaniline nanofiber dispersions and films
A new method for forming stable polyaniline nanofiber colloids uses electrostatic repulsion to maintain dispersion of the nanofibers and prevent aggregation during synthesis of the nanofibers. The colloidal suspensions are formed directly from the reactants in solution maintained at a pH of about 1.0 to about 4.0 and a temperature of about 10° C. to about 100° C. with minimal or no stirring. Also set forth are new methods for forming ultrathin films of polyaniline nanofibers via self-assembly.
US08470199B2 Five-ring liquid crystal compound, liquid crystal composition and liquid crystal display device
The invention provides a liquid crystal compound having a high stability to heat, light or the like, a nematic phase in a wide temperature range, a small viscosity, a suitable optical anisotropy (especially, a relatively small optical anisotropy), a large elastic constant K33 and a suitable dielectric anisotropy (especially, a relatively large dielectric anisotropy), which is represented by formula (1-1). For example, R1 and R2 are alkyl having 1 to 10 carbons, alkenyl having 2 to 10 carbons or alkoxy having 1 to 9 carbons; the ring A1 and the ring A2 is 1,4-phenylene, 2-fluoro-1,4-phenylene, 3-fluoro-1,4-phenylene or 3,5-difluoro-1,4-phenylene; and m and n are 0, 1, 2 or 3, and the sum of m and n is 3.
US08470195B2 Chemical mechanical polishing aqueous dispersion preparation set, method of preparing chemical mechanical polishing aqueous dispersion, chemical mechanical polishing aqueous dispersion, and chemical mechanical polishing method
A chemical mechanical polishing aqueous dispersion preparation set including: a first composition which includes colloidal silica having an average primary particle diameter of 15 to 40 nm and a basic compound and has a pH of 8.0 to 11.0; and a second composition which includes poly(meth)acrylic acid and an organic acid having two or more carbonyl groups other than the poly(meth)acrylic acid and has a pH of 1.0 to 5.0.
US08470194B2 Ni—Zn—Cu ferrite particles, green sheet comprising the Ni—Zn—Cu ferrite particles and Ni—Zn—Cu ferrite sintered ceramics
A Ni—Zn—Cu ferrite material having excellent DC bias characteristics is provided by adding zinc silicate thereto. The above problem can be solved by Ni—Zn—Cu ferrite particles which comprise a spinel-type ferrite and zinc silicate, which have a composition comprising 36.0 to 48.5 mol % of Fe2O3, 7.0 to 38 mol % of NiO, 4.5 to 40 mol % of ZnO, 5.0 to 17 mol % of CuO and 1.0 to 8.0 mol % of SiO2, all amounts being calculated in terms of the respective oxides, and which have a ratio of an X-ray diffraction intensity from a 113 plane of the zinc silicate to an X-ray diffraction intensity from a 311 plane of the spinel-type ferrite is 0.01 to 0.12; a green sheet obtained by forming a material comprising the Ni—Zn—Cu ferrite particles into a film; and a Ni—Zn—Cu ferrite sintered ceramics.
US08470190B2 Method for processing portions of walls of an opening formed in a silicon substrate
A method for processing at least one wall of an opening formed in a silicon substrate, successively including the steps of implanting fluorine atoms into an upper portion of the wall of the opening, performing an oxidization step, and applying a specific processing to at least a portion of the non-implanted portion of the opening.
US08470189B2 Method of forming mask pattern, method of forming thin film pattern and method of forming magnetoresistive element
In the present invention, provided is a method of forming a mask pattern by which a fine thin film pattern may be formed more easily with higher resolution and precision. In the method of forming a mask pattern, a photoresist pattern having an opening is formed on a substrate, then, an inorganic film is formed so as to cover the upper surface of the photoresist pattern and the inside of the opening, then the inorganic film on the upper surface of the photoresist pattern is removed by a dry etching process. Subsequently, an inorganic mask pattern is formed by removing the photoresist pattern. The inorganic mask pattern thus formed hardly produces an issue of deformation such as physical displacement even when it is heated in the dry etching process.
US08470188B2 Nano-imprint lithography templates
Porous nano-imprint lithography templates may include pores, channels, or porous layers arranged to allow evacuation of gas trapped between a nano-imprint lithography template and substrate. The pores or channels may be formed by etch or other processes. Gaskets may be formed on an nano-imprint lithography template to restrict flow of polymerizable material during nano-imprint lithography processes.
US08470187B2 Method of depositing film with tailored comformality
A method of depositing a film with a target conformality on a patterned substrate, includes: depositing a first film on a convex pattern and a bottom surface; and depositing a second film on the first film, thereby forming an integrated film having a target conformality, wherein one of the first and second films is a conformal film which is non-flowable when being deposited and has a conformality of about 80% to about 100%, and the other of the first and second films is a flowable film which is flowable when being deposited.
US08470181B2 Surface-reacted calcium carbonate in combination with hydrophobic adsorbent for water treatment
The present invention relates to a process for reducing the amount of organic components in water, wherein a surface-reacted naturalcalcium carbonate and a hydrophobic adsorbent, selected from the group consisting of talc, hydrophobized calcium carbonate, hydrophobized bentonite, hydrophobized kaolinite, hydrophobized glass, or any mixture thereof, are brought into contact with the water to be purified, the surface-reacted natural calcium carbonate being the reaction product of a naturalcalcium carbonate with an acid and carbon dioxide, which is formed in situ by the acid treatment and/or supplied externally, and the surface-reacted natural calcium carbonate being prepared as an aqueous suspension having a pH of greater than 6.0, measured at 20° C.
US08470180B2 Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams
A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.
US08470178B2 Organic oil boom
An organic oil boom is a method for containing pollution floating on water or the sea. The invention describes a method that makes it possible to isolate pollution as, for example, oil, from the surrounding environment. Spraying a viscous liquid such as an alginate or chitosan solution over and around the oil results in isolation of the oil from the seawater as the mixture has a density that is lighter than seawater and heavier than oil. To isolate the oil also from the air, a gas is added so that the density of the mixture is lower than the density of the oil. The addition of a multivalent cation solution such as calcium ions will, under the right pH conditions, polymerise the viscous liquid, thus forming a solid polymer film which surrounds the oil and isolates it from the surrounding environment.
US08470177B2 Method and apparatus for anaerobic digestion of organic liquid waste streams
A system and method for treating high-strength organic liquid waste. Generally, the method includes feeding influent high-strength organic liquid waste including organic molecules to an anaerobic digester, converting at least a portion of the organic molecules in the liquid waste to acids using acid forming bacteria, converting at least a portion of the acids in the liquid waste to methane using methanogenic bacteria, separating the liquid waste after treatment with the methanogenic bacteria into alkaline sludge and effluent, and using the alkaline sludge to adjust the pH of the liquid waste in the anaerobic digester. In the case of acidic high-strength organic liquid wastes, a portion of the acids produced by the acid forming bacteria may be recirculated to the front of the anaerobic digester and combined with influent high-strength organic liquid waste.
US08470174B2 Filtration arrangement for micro, ultra and nanofiltration
The invention relates to a filtration device including a flat filter module and a base housing, on which the flat filter module is placed. A wall of the base housing includes a polymer cellular lightweight construction material, or a fiber composite material.
US08470168B2 Heat exchanger system
A heat exchanger system through which a liquid can flow, including a heat exchanger including a liquid inlet and a liquid outlet, a bypass valve including a liquid inlet and a liquid outlet, and a self-cleaning filter including a liquid inlet and two liquid outlets, one being an outlet for filtered liquid and one being an outlet for non-filtered liquid. The outlet for filtered liquid is connected to the inlet of the exchanger and the outlet for non-filtered liquid is connected to the inlet of the valve. The outlet of the heat exchanger is connected downstream of the outlet of the valve. A fuel circuit of an airplane jet engine can include such a system.
US08470163B2 Exhaust gas sensor and method of manufacture
A method of manufacturing an exhaust gas sensor that includes positioning at least a portion of a subassembly of the exhaust gas sensor in a mold fixture, overmolding at least a portion of the subassembly with a ceramic material, and removing the overmolded subassembly from the mold fixture.
US08470162B2 Biosensor, thin film electrode forming method, quantification apparatus, and quantification method
Quantifying devices and methods are disclosed for quantifying substrate content using a biosensor where the methods include a first detecting step for detecting an electrical change generated between a measuring electrode and a counter electrode of a biosensor by applying a sample liquid to the biosensor; a second detecting step for detecting an electrical change generated between a detecting electrode of the biosensor and the counter electrode or the measuring electrode by applying the sample liquid to the biosensor; and a notification step for informing a user when the second detecting step does not occur within a predetermined period after the first detecting step.
US08470161B2 Biomass production and harvesting system
A self-contained system which promotes the multiplication of algae from either salt water or fresh water sources as a feedstock. This process inspires a direct output of lipids for bio-diesel fuel as well as a significant raw algae yield which can be further processed into additional bio-fuel as well as other valuable resources. In addition to inspiring a direct output of algal lipids for bio-diesel, the system generates massive raw algae biomass output that can be directly utilized as an agent for efficiently cleaning up oil spills.
US08470156B2 Electrochemical process and production of novel complex hydrides
A process of using an electrochemical cell to generate aluminum hydride (AlH3) is provided. The electrolytic cell uses a polar solvent to solubilize NaAlH4. The resulting electrochemical process results in the formation of AlH3. The AlH3 can be recovered and used as a source of hydrogen for the automotive industry. The resulting spent aluminum can be regenerated into NaAlH4 as part of a closed loop process of AlH3 generation.
US08470155B2 Copper/niobium composite piping material produced by copper electroforming, process for producing the same and superconducting acceleration cavity produced from the composite piping material
In order to produce industrially advantageously an electroformed copper/niobium composite piping material wherein an electroformed copper layer and a niobium thin piping material are strongly bonded to each other, the electroformed copper/niobium composite piping material can be produced by coating any one or each of the outer peripheral surface and the inner peripheral surface of a niobium thin piping material with a nickel thin film, coating the surface of the nickel thin film with copper by electroforming, and subsequently annealing the resultant.
US08470152B2 Method of operating a capacitive deionization cell using gentle charge
A method of operating a capacitive deionization cell using charge potentials of 1 V or less.
US08470149B2 Electrowetting dispensing devices and related methods
A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.
US08470148B2 Method for sample application
The present invention relates to a method for sample application and separation. More closely, the invention relates to convenient direct loading of a biomolecule sample via magnetic beads to, for example, a gel before electrophoresis. In this way, the invention combines elution and application steps with minimal losses of sample. Thus, the invention relates to a method for sample application of biomolecules on a separation media, comprising the following steps: a) obtaining said biomolecules from a sample by magnetic beads; b) applying the magnetic beads with the biomolecules to a separation medium; c) releasing the biomolecules into the separation media, and d) separation of the biomolecules from each other in the separation medium.
US08470146B2 Cable insertion for corrosion sensors
A method and apparatus for sensing corrosion comprises a casing and a counter-electrode. The casing is made of material that is substantively incompressible at pressures on wires within a structural cable. The casing has a thickness that is not greater than typical interstitial spaces between wires of the structural cable and has a length on an order of a radius of the structural cable. The counter-electrode exchanges electrons with ions of an electrolyte that corrodes the wires of the structural cable. The counter-electrode is embedded in the casing, is exposed to the electrolyte in a window of the casing, and is recessed to avoid contact with any wire of the structural cable when the sensor is deployed among the wires of the structural cable.
US08470142B2 Sputtering apparatus and driving method thereof
A sputtering apparatus for depositing a target material on a substrate includes a chamber, a target in the chamber to provide the target material, a carrier to carry the substrate in the chamber to face the target, and a plurality of masks arranged along sides of the carrier and being movable back and forth with respect to the carrier.
US08470140B2 Method for the production of an ultra barrier layer system
The invention relates to a method for producing an ultrabarrier layer system through vacuum coating a substrate with a layer stack that is embodied as an alternating layer system of smoothing layers and transparent ceramic layers, but comprising at least one smoothing layer between two transparent ceramic layers, which are applied by sputtering, in which during the deposition of the smoothing layer a monomer is admitted into an evacuated coating chamber in which a magnetron plasma is operated.
US08470139B2 Systems and method for low temperature recovery of fractionated water
In accordance with one embodiment, a method for treating fractionated water produced by a hydraulic fracturing process is provided. The method includes decanting a fractionated water stream in at least one decanter. The decanter is maintained at a temperature ranging from about 90° F. to about 120° F. The method also includes flashing the decanted water in at least one first flash tank and at least one second flash tank in fluid communication with one another to provide a residual concentrate stream. The first flash tank is operated at a temperature ranging from about 180° F. to about 200° F. and the second flash tank is operated at a temperature ranging from about 140° F. to about 160° F. Both the first flash tank and the second flash tank are maintained at a vacuum pressure. The method also includes evaporating the residual concentrate stream in at least one evaporator kettle to produce a concentrated brine. The evaporator kettle is fluidly connected to the second flash tank, and the evaporator kettle is operated at a temperature ranging from about 95° F. to about 115° F. The evaporator kettle is maintained at a vacuum pressure. The method also includes dewatering the concentrated brine to produce recovered salt having less than about 20 wt. % water.
US08470137B2 Recycler assembly
An assembly for recycling a solvent from a contaminated solvent solution includes a reservoir module connected to a recycler module. The reservoir module includes a mounted reservoir including an interior volume and a removable lid that reduces the interior volume and includes an access port. The recycler module includes a distillation assembly and an air handler assembly. The distillation assembly includes a distiller and a conduit including a condenser and a sight glass. The air handler assembly includes a duct having an intake port, an exhaust port and a source of air flow. The condenser is disposed within the duct and the sight glass is disposed external to the duct.
US08470136B2 Parts washer with recycler assembly
An assembly for removing contaminants from objects and recycling a solvent from a contaminated solvent solution includes a parts washer assembly including a container for a contaminated solvent solution and a recycling assembly that includes a reservoir module connected to a recycler module. The reservoir module includes a mounted reservoir including an interior volume and a removable lid that reduces the interior volume and includes an access port. The recycler module includes a distillation assembly and an air handler assembly. The distillation assembly includes a distiller and a conduit including a condenser and a sight glass. The air handler assembly includes a duct having an intake port, an exhaust port and a source of air flow. The condenser is disposed within the duct and the sight glass is disposed external to the duct.
US08470135B2 Method and apparatus for minimizing accumulation of polymer on process equipment, especially safety devices
Accumulation of polymer on equipment, which is in contact with polymerizable material during normal process operation, is minimized by the method and apparatus of the present invention. The method involves positioning and affixing the equipment, such as a pressure relief device, to process apparatus, such as a distillation column, proximate to a wetted region formed by liquid phase fluid in the process apparatus, such that the moving liquid phase fluid is at least intermittently in contact with the equipment and one or more of accumulated polymerizable material, condensate including same, and polymer, is washed off of the equipment. The apparatus of the present invention is effective for maintaining the service-readiness of the equipment, which provides for safe long-term operation of the process apparatus.
US08470130B2 Universal die detachment apparatus
A die detachment apparatus for partially delaminating a die from an adhesive tape on which it is mounted comprises a cover having a support surface that is operative to support the adhesive tape, the support surface including a set of cover holes. A movable pin chuck is positioned below the support surface and includes a set of pin holes that are arranged coaxially with the cover holes. The movable pin chuck is configured for detachably inserting a set of pins in a first desired configuration on some of the pin holes, and the pins are also operable to be relocated on the pin chuck to form another desired configuration. The pins are operative to protrude from the cover by passing through the cover holes to contact and lift the die.
US08470123B2 Pressure sensitive adhesive for sticking an electromagnetic wave-shielding film and an optically functional film, and a display panel filter element containing same
A pressure sensitive adhesive for sticking together an electromagnetic wave-shielding film and optically functional film, wherein a storage elastic modulus at 70° C. is 7.00×104 Pa or more; and a display panel filter element comprising (1) an electromagnetic wave-shielding film, the film being a laminate of a transparent substrate film, an adhesive for a metal foil, which is applied on one surface of the transparent substrate film, and a metal foil mesh formed on the adhesive for a metal foil, (2) a layer of the pressure sensitive adhesive according to (1), which is applied so as to cover the metal foil mesh of the electromagnetic wave-shielding film, and (3) an optically functional film provided on the pressure sensitive adhesive, are provided. The pressure sensitive adhesive exhibits sufficient adhesive strength, can be filled into the inside of the pores of the metal foil mesh, and does not generate bubbles in a heating treatment.
US08470117B2 Method of manufacture for a flexible packaging film with reclosure
In a method of manufacture for a packaging film, a pour-hole film strip is supplied to a film web and with its film strip sealing layer is attached to that side of the film web which, when the packaging film is used as prescribed, forms a film inner side of the packaging so that a tensile force can be transmitted via a pull tab in the packaging film to a separating region in the film strip sealing layer and said separating region and an adjoining region of an adhesive layer form a reclosure cooperating with the pull tab.
US08470115B2 Adhesive sheet and method for manufacturing the same, semiconductor device manufacturing method and semiconductor device
An adhesive sheet comprising a release substrate 10, a substrate film 14, and a first tacky-adhesive layer 12 placed between the release substrate 10 and the substrate film 14, wherein an annular incision D is formed on the release substrate 10 from the surface of the first tacky-adhesive layer 12 side, the first tacky-adhesive layer 12 is laminated so as to cover the whole inner surface of the incision D in the release substrate 10, and the incision D has a depth d of less than the thickness of the release substrate 10 and 25 μm or less.
US08470114B2 Method of preparing thermoplastics-continuous fiber hybrid composite
Provided is a method of preparing thermoplastics-continuous fiber hybrid composite, which is easily woven and has excellent uniformity and impregnation at the time of hot melt impregnation after the weaving, including: a) widely and uniformly stretching a bundle of glass fibers; b) heating the stretched glass fibers; c) preparing a thermoplastics-continuous fiber bonding material by binding the heated glass fiber with thermoplastics; d) preparing a multi-layered thermoplastics-continuous fiber bonding material by folding the bonding material in a shape of zigzag; and e) pressing the multi-layered thermoplastics-continuous fiber bonding material.
US08470104B2 High strength valve spring for vehicle engine and method of manufacturing the same
A method of manufacturing a high strength valve spring for a vehicle engine is provided, which includes (a) forming a high strength wire rod in the form of a spring using a roller type jig, (b) cutting an end of the formed spring using a rotary type cutting blade, (c) performing residual stress removal heat treatment at 390° C. to 410° C. for 20 to 40 minutes, (d) performing shot peening for applying compression stress to a surface of the spring with fine ball particles, and (e) performing hot setting for applying, in advance, plastic deformation to the spring. Accordingly, the damage of the spring during the spring forming process is prevented, and the hardness deterioration of the spring during the residual stress removal heat treatment process is also prevented.
US08470103B2 Method of making a Cu-base bulk amorphous alloy
The present invention provides Cu-base amorphous alloys containing an amorphous phase of 90% or more by volume fraction. The amorphous phase has a composition represented by the formula: Cu100-a-b(Zr+Hf)aTib or Cu100-a-b-c-d(Zr+Hf′)aTibMcTd, wherein M is one or more elements selected from Fe, Cr, Mn, Ni, Co, Nb, Mo, W, Sn, Al, Ta and rare earth elements, T is one or more elements selected from the group consisting of Ag, Pd, Pt and Au, and a, b, c and d are atomic percentages falling within the following ranges: 5≦a≦55, 0≦b≦45, 30≦a+b≦60, 0.5≦c≦5, 0≦d≦10. The Cu-base amorphous alloy has a high glass-forming ability as well as excellent mechanical properties and formability, and can be formed as a rod or plate material with a diameter or thickness of 1 mm or more and an amorphous phase of 90% or more by volume fraction, through a metal mold casting process.
US08470101B2 Lead-free copper alloy for casting with excellent mechanical properties
Disclosed is a lead-free copper alloy for casting which contains 0.1-0.7% of S, 8% or less (excluding 0%) of Sn, and 6% or less (excluding 0%) of Zn, and in which a sulfide is dispersed and the average spheroidization ratio of the sulfide is 0.7 or greater. Due to this constitution, said lead-free copper alloy for casting has excellent mechanical properties such as strength, high pressure resistance and good machinability and, therefore, is useful as a starting material for faucet metal fittings, water faucet and so on, even though the alloy contains no lead which causes deterioration of water.
US08470100B2 Copper alloys and heat exchanger tubes
Alloys containing copper, iron, tin and, optionally, phosphorus or copper, zinc, tin and, optionally, phosphorus, which can be used in, for example, a copper alloy tube for heat exchangers that provides excellent fracture strength and processability for reducing the weight of the tube and for use in high pressure applications with cooling media such as carbon dioxide.
US08470098B2 Metal gasket
A metal gasket includes embossments that exhibit essentially full functional recovery and full retained internal stress at temperatures up to about 1000° F. which is made from sheet material that is cold rolled and whose embossments are work hardened without any post embossment heat treating that would act to harden the material. This material may also receive a precipitation hardening heat treatment prior to being embossed. The gasket materials include alloys having greater than about 18% Ni, greater than about 14% Cr, from about 0.1 to 10% of at least one of Mo, Ti, V, Al, Co, Nb, Ta or Cu and the balance Fe with incidental impurities, which are cold rolled without any post embossment heat treating that would act to harden the material.
US08470097B2 Silicon-containing steel compostition with improved heat exchanger corrosion and fouling resistance
A method of providing sulfidation corrosion resistance and corrosion induced fouling resistance to a heat transfer component surface includes providing a silicon containing steel composition including an alloy and a Si-partitioned non-metallic film formed on a surface of the alloy. The alloy is formed from the composition η, θ,and τ, in which η is a metal selected from the group consisting of Fe, Ni, Co, and mixtures thereof, θ is Si, and τ is at least one alloying element selected from the group consisting of Cr, Al, Mn, Ti, Zr, Hf, V, Nb, Ta, Mo, W, Sc, La, Y, Ce, Ru, Rh, Ir, Pd, Pt, Cu, Ag, Au, Ga, Ge, As, In, Sn, Sb, Pb, B, C, N, P, O, S and mixtures thereof. The Si-partitioned non-metallic film comprises at least one of sulfide, oxysulfide and mixtures thereof.
US08470094B2 Apparatus for continuous coating
Apparatus for continuous coating has a chamber wall which forms a processing chamber, thermal insulation which forms a processing area within the chamber, a transportation device for substrates located in the processing area with a substrate transportation direction of the substrates lying in the lengthwise extension of the apparatus for continuous coating, and heating equipment which heats the substrates, is designed to minimize unwanted coating, in particular of parts of the apparatus, in order to minimize the expense of maintaining and servicing the apparatus A condensation element is positioned in the processing chamber, which extends into the processing area and binds the arising vapor through condensation.
US08470093B2 Device for pulling a single crystal
A device for pulling a single crystal from a melt having a widened portion between an upper and a lower neck portion including a pulling device having a pulling device cable drum configured to wind a pulling cable, the pulling cable configured to pull the single crystal and a supporting device configured to relieve the upper neck portion of a weight of the single crystal.
US08470091B2 SiC single crystal substrate, SiC single crystal epitaxial wafer, and SiC semiconductor device
A direction of a dislocation line of a threading dislocation is aligned, and an angle between the direction of the dislocation line of the threading dislocation and a [0001]-orientation c-axis is equal to or smaller than 22.5 degrees. The threading dislocation having the dislocation line along with the [0001]-orientation c-axis is perpendicular to a direction of a dislocation line of a basal plane dislocation. Accordingly, the dislocation does not provide an extended dislocation on the c-face, so that a stacking fault is not generated. Thus, when an electric device is formed in a SiC single crystal substrate having the direction of the dislocation line of the threading dislocation, which is the [0001]-orientation c-axis, a SiC semiconductor device is obtained such that device characteristics are excellent without deterioration, and a manufacturing yield ration is improved.
US08470087B2 Production method for a lightweight construction material using asbestos waste
The present invention relates to a production method for a lightweight construction material using asbestos waste, and more specifically to a production method for a lightweight construction material using asbestos waste in which the production takes place with the addition of loess, silicon carbide, a zeolite and half silty clay to asbestos waste, and relates to a lightweight construction material produced thereby. By adding silicon carbide, loess, a zeolite and half silty clay to asbestos waste, the present invention has the advantageous effect that construction materials can be made lighter in weight without the asbestos component being detected, and an environmentally friendly lightweight construction material can be produced which has outstanding strength, thermal insulation properties, forming properties, water-absorbing power and water-retaining ability.
US08470080B1 High pressure separator
A high pressure horizontal vessel separator for separating petroleum mixtures. An inlet on one end of the vessel and gas, water, and oil outlets provided on an opposite end, with each outlet having a vortex breaker. The inlet communicating with a momentum absorbing, flow distributing inlet diverter that causes the gas to separate into the top of the main section of the vessel and the fluids to flow to the bottom of the main section. Sediment collects in the bottom of the main section and is removed via a sand trap. Water remains at the bottom of the vessel, and the fluids flow through a perforated baffle then through a bent lamella demister before entering a settling portion of the vessel where gas and water exit via the gas and water outlets and oil flows over an oil weir and exits downstream of the weir via the oil outlet.
US08470078B2 Process for removing tar from synthesis gas
A process and system for removing tars from synthesis gas uses glycerol produced as a byproduct of biodiesel manufacture. The biodiesel may be made from various oil feedstocks such as canola, rapeseed, or soybean oils. Associated with the harvesting of these crops may be the ready availability of byproduct biomass useful as feedstock for gasification. In addition, methanol may be sourced from the gasification of biomass to exploit a potential synergy between biodiesel manufacture and biomass gasification. The present invention develops those synergies further by making use of a byproduct stream from the manufacture of biodiesel to remove tars from the gasifier synthesis gas and to provide a useful end use for the byproduct.
US08470074B2 Carbon dioxide sorbents
Improved CO2 sorbents comprised of a mesoporous silica functionalized with a polyamine are obtained by the in-situ polymerization of azetidine. Also included herein are processes utilizing the improved CO2 sorbents wherein CO2 is chemisorbed onto the polyamine portion of the sorbent and the process is thermally reversible.
US08470070B2 Ash detection in diesel particulate filter
Detecting ash in a diesel particulate filter includes receiving data indicative of signal attenuation for ash-responsive and ash-insensitive RF signals transmitted through a diesel particulate filter containing trapped soot and ash. A difference between the RF signals, such as a difference in signal attenuation, may be leveraged to detect a relative ash loading state or a change in relative ash loading state of the diesel particulate filter, and responsively indicate that filter cleaning is needed.
US08470068B2 Method and system for producing metallic iron nuggets
Method and system for producing metallic nuggets includes providing reducible mixture of reducing material (such as carbonaceous material) and reducible iron bearing material (such as iron oxide) that may be arranged in discrete portions, such as mounds or briquettes, on at least a portion of a hearth material layer (such as carbonaceous material). A coarse overlayer of carbonaceous material may be provided over at least some of the discrete portions. Heating the reducible mixture to 1425° C. or 1400° C. or 1375° C. results in formation of an intermediate product of one or more metallic iron nuggets, which may have a sulfur content of less than 0.03%, and slag, which may have less than 5% mass MgO, which may have a ratio of percent by weight sulfur in the slag over percent by weight sulfur in the metallic nuggets of at least about 12 or at least about 15.
US08470066B2 Aqueous-based method for producing ultra-fine metal powders
The present invention provides a method for forming compositions having a plurality of ultra-fine metallic particles, and the metallic composition produced therewith. Also provided is a substrate coated with the plurality of ultra-fine metallic particles obtained in accordance with the method of the present invention.
US08470062B2 Drain tube for gas-liquid separation systems
A drain tube for an air-oil separator system, the tube being configured vertically in the system, the tube having an upper opening for receiving oil separated from air in the system, and a lower opening for releasing oil separated from air in the system, wherein the upper opening has a horizontal cross-sectional area that is greater than a horizontal cross-sectional area of the lower opening.
US08470058B2 Diesel fuel combustion enhancing additive
Embodiments disclosed herein generally relate to the use of low concentration additives comprising a terpene and a cetane improver in diesel fuel to rapidly promote fuel atomization and air mixing in the combustion chamber and thereby increase the fuel efficiency and reduce harmful NOx and particulate exhaust emissions.
US08470056B2 Non-aqueous electrolyte secondary battery and method for producing the same
The method for producing a non-aqueous electrolyte secondary battery of the invention includes: (a) a step of preparing an electrode mixture slurry, (b) an ionization step of oxidizing and ionizing a metal impurity present in the electrode mixture slurry, and (c) a step of producing an electrode by using the electrode mixture slurry after the ionization step. In the invention, when the electrode mixture is in the form of a slurry, the metal impurity contained in the electrode mixture is ionized to minimize the amount of the impurity. Therefore, the invention can provide a highly reliable non-aqueous electrolyte secondary battery while minimizing a decrease in production yield by the metal impurity.
US08470054B2 Azo compound, azo pigment, pigment dispersion, coloring composition, color filter, ink for inkjet recording, and printing ink
Provided are an azo compound represented by the following formula (1), a tautomer thereof, and a salt or hydrate of the azo compound or the tautomer: wherein in the formula (1), A represents a heterocyclic group; G represents a hydrogen atom, an aliphatic group, an aromatic group, or a heterocyclic group; R1 and R2 each independently represent a group represented by the following formula (2) or (3):
US08470052B2 Phenoxypyrazole composition and process for the solvent extraction of metals
Methods for extracting metals from aqueous solutions, by contacting an aqueous solution containing a dissolved metal with a solvent extraction composition having a water-immiscible organic solvent; and a metal extractant compound according to Formula (1) and tautomers and salts thereof, are disclosed herein, wherein substituents R5-8, Y, and Z are as described herein.
US08470050B2 Rapid fit modular prosthetic device for accommodating gait alignment and residual limb shape and volume
A Rapid Fit Modular Prosthetic Device that can be inexpensively manufactured using modern technology and advanced polymer materials. The Rapid Fit Modular Prosthetic Device will be immediately fit on the residual limb and aligned for optimal gait without specialized tools or labs, alleviating the many steps involved with conventional labor-intensive and costly prosthesis construction. The Rapid Fit Modular Prosthetic Device also accommodates the changing in size and shape of the limb, eliminating the need for multiple prostheses and adjustments to an existing prosthesis during the lifetime of an amputee.
US08470047B2 Fixed-bearing knee prosthesis
A fixed-bearing prosthesis includes a femoral component having a medial condyle surface and a lateral condyle surface. The knee prosthesis also includes a bearing having a medial bearing surface configured to articulate with the medial condyle surface of the femoral component, and a lateral bearing surface configured to articulate with the lateral condyle surface of the femoral component. A tibial tray is secured to the bearing. The tibial tray has a platform with an elongated stem extending downwardly from a lower surface thereof. A peripheral rail extends along at least an anterior section of the perimeter of the tray's platform. The peripheral rail extends upwardly from an upper surface of the platform. A retaining rail extends upwardly from the upper surface of the platform and posteriorly away from the peripheral rail.
US08470046B2 Bone augmentation device and method
A bone augmentation device includes at least one axial member defining a longitudinal axis and a plurality of transverse members. Each transverse member extends from a first end, or removably connected to the at least one axial member to a second end configured for fixation with bone. The transverse members are spaced apart and disposed along the longitudinal axis. The at least one axial member and the transverse members are disposed in a configuration to define a bone graft cavity. Methods of use are also disclosed.
US08470043B2 Tissue removal tools and methods of use
Discectomy or disc preparation system that includes a guide member that is changeable from a deployment configuration for insertion into an intervertebral disc space to a deployed configuration upon being deployed into the intervertebral disc. The system also includes at least one tissue manipulator, such as cutting, scraping and extraction elements, that can be moved or tracked longitudinally along the guide member into and through the intervertebral disc space.
US08470040B2 Intervertebral implant devices for supporting vertebrae and devices and methods for insertion thereof
Implant devices for implantation within an intervertebral space are provided, together with methods and tools for use therewith. Implant devices of the present invention include an implant body formed of a synthetic bone substitute material, such as a nanocrystalline calcium phosphate material. The implant body and the methods and tools used therewith are configured to optimize strength and stability of the implant, minimize areas of stress concentration in the implant body and promote bone growth through the implant body and fusion of the vertebra.
US08470031B2 Device for folding or rolling an intraocular lens to be implanted into an eye
A device for folding or rolling up an intraocular lens 1 that is to be implanted into an eye, with a lens receiving compartment 2 that is formed by two swivel-connected lens receiving parts 3, 4, which lens receiving compartment 2 is to be moved from an open position for receiving the lens 1, in which the lens is unfolded, into a closed position for folding or rolling up the lens 1 by swiveling the lens receiving parts 3, 4 relative to each other, and with a holding device which is formed by two holding elements 5, 6, one of which holding elements 5 is attached to one lens receiving part 3 and the other holding element 6 is attached to the other lens receiving part 4.
US08470030B2 Device for loading an intraocular lens into an injection cartridge
Disclosed are a device for loading a flexible intraocular lens into an injection cartridge capable of serving as a packaging support, an injection cartridge and a set formed by said loading device and an injection cartridge. The loading device comprises a tubular element (1) having an internal passage (10), said passage comprising a receiving section (11), an intermediate truncated folding section (12) and an end section (13) capable of receiving an injection cartridge detachably, a supporting element (3) mounted in said receiving section, capable of supporting a lens in a non-folded state, and a plunger (5) capable of pushing a lens (9) positioned in the receiving section through the truncated intermediate folding section to fold said lens gradually, then in the receiving chamber of an injection cartridge placed in the end section.
US08470028B2 Methods, systems and devices for cardiac valve repair
Disclosed are devices and methods for treating regurgitation through a valve in the heart. The devices can include an expandable, fluid-tight bladder configured to be deployed between valve leaflets of the heart valve. The bladder can include an upper portion that extends into the atrium of the heart; a lower portion that extends into the ventricle of the heart; and a middle portion positionable within the line of valve leaflet coaptation that provides a sealing surface for one or more of the leaflets.
US08470027B2 Devices and a kit for improving the function of a heart valve
A device for improving the function of a heart valve comprises a first loop-shaped support, which is configured to abut a first side of the heart valve, and a second loop-shaped support, which is configured to abut a second side of the heart valve opposite to said first side, whereby a portion of the valve tissue is trapped between the first and second supports. An outer boundary of the second support is greater than an outer boundary of the first support.
US08470026B2 Mechanical heart valve apparatus
A mechanical heart valve apparatus includes a loop-shaped frame defining a valve opening and formed with a pair of transverse slot units and a pair of longitudinal slots; and a pair of valve plates mounted on the loop-shaped frame. Each of the valve plates includes a pair of first studs that are slidably and respectively inserted into the transverse slot units, and a second stud that is slidably inserted into a respective one of the longitudinal slots. The valve plates are pivoted to each other so as to be rotatable relative to each other between a closed position, in which the second studs are disposed adjacent to upper ends of the longitudinal slots, and an opening position, in which the second studs are disposed adjacent to lower ends of the longitudinal slots.
US08470025B2 Cardiovascular procedures
A method for performing cardiovascular and surgical procedures includes providing a conduit in the form of a graft/canula placed using balloon dilatation catheter and providing a fixing mechanism for the graft/canula. At least one opening is formed through a wall of the heart substantially at the apex. The escape of blood is prevented through the use of the fixing mechanism. Each of these steps is performed while the heart is beating.
US08470023B2 Percutaneous valve, system, and method
Apparatus, systems, and methods for percutaneous valve replacement and/or augmentation are provided. The apparatus includes a valve having a valve frame, a valve leaflet coupled to the valve frame, and a leaflet transition member coupled to the valve leaflet. The valve leaflet and leaflet transition member can transition from a first position where the valve leaflet and leaflet frame are at least partially outside a lumen of the valve frame to a second position where the valve leaflet and the leaflet transition member are within the lumen of the valve frame.
US08470021B2 Radially expandable stent
An expandable stent radially adjustable between a collapsed state and an expanded state. The stent generally includes a main body and a plurality of connector segments. The main body has first and second ends, a longitudinal axis extending from the first end to the second end, and a plurality of ring structures. Each of the plurality of connector segments joins adjacent ring structures. Some ring structures may be connected by a pair of diamond connector segments that define a diamond-shaped portion when the stent is in the expanded state. Some ring structures may be connected by flex connector segments oriented to permit rotation of the second ring structure about the longitudinal axis during radial expansion of the stent.
US08470020B2 Intralumenally-implantable frames
Implantable frames for use in body passages are provided herein. The implantable frames can include a plurality of hoop members joined by a plurality of longitudinal connecting members to form a tubular frame defining a cylindrical lumen. The plurality of longitudinal connecting members may include first and second longitudinal connecting members joining a first hoop member to a second hoop member such that the first and second longitudinal connecting members extend across an entire space separating the first and second hoop members.
US08470018B2 Fenestration for stent graft arrangements and stent graft including the same
A fenestration (32) for a stent graft (30). The fenestration is an aperture in the biocompatible graft material and has at least one flap (38, 40) of a biocompatible graft material covering the aperture on the inside whereby the flap closes off the aperture but can be displaced to allow access through the fenestration. An array of such fenestrations may be placed on a stent graft to facilitate alignment of a branch vessel with a fenestration. A slip knot (46, 46) which can be released by forcing a dilator between the flaps can be used to hold the flaps together.
US08470014B2 Stent-catheter assembly with a releasable connection for stent retention
Medical assemblies with a releasable connection and methods of constructing such medical assemblies are disclosed. The medical assemblies generally comprise a stent, a catheter assembly having catheter body a balloon, and a releasable connection between the stent and the catheter assembly that releases the stent from the catheter assembly in response to enlargement of the balloon or when the balloon has been enlarged to an expanded configuration.
US08470010B2 Systems and methods for treating superficial venous malformations like spider veins
Systems and methods treat superficial venous malformations, such as spider veins. The systems and methods distribute a reactive agent, e.g., a light-reactive agent such as talaporfin sodium or verteporfin, at or near an inner wall of a vein. The systems and methods activate the reactive agent by applying energy, e.g. non-thermal light energy at a wavelength that activates the reactive agent to cause localized injury to the inner wall of the vein.
US08470008B2 Modular fastener assemblies for spinal stabilization systems and methods
A fastener assembly for engaging vertebral elements has a connecting body that includes a receptacle extending between a first opening and a second opening and a fastener with a head movably supported in the receptacle. The fastener includes a vertebral engaging portion extending distally through the second opening. The fastener assembly further includes a post that has an elongated body with a proximal portion extending proximally from the first opening of the connecting body, a distal engagement end in the receptacle, and an adjusting portion extending between the proximal portion and the engagement end. The adjusting portion is movably engaged to the connecting body to position the engagement end relative to the head of the fastener to substantially fix the head in the receptacle and resist movement of the fastener with respect to the post and the connecting body.
US08470004B2 Apparatus, systems, and methods for stabilizing a spondylolisthesis
Assemblies of one or more implant structures make possible the achievement of diverse interventions involving the fusion and/or stabilization of lumbar and sacral vertebra in a non-invasive manner, with minimal incision, and without the necessitating the removing the intervertebral disc. The representative lumbar spine interventions, which can be performed on adults or children, include, but are not limited to, lumbar interbody fusion; translaminar lumbar fusion; lumbar facet fusion; trans-iliac lumbar fusion; and the stabilization of a spondylolisthesis.
US08470001B2 Polyaxial screw
A bone-anchoring device is provided. The bone-anchoring device may comprise a screw including a threaded shaft portion configured to engage bone tissue, and a head portion having a cup-shaped cavity. The device may further include a rod connector and a linking member, wherein the linking member includes a spherical head portion configured to engage the cup-shaped cavity of the head of the screw, a widened flange s configured to engage the linking member, and an elongate body extending from the widened flange portion and configured to extend through an opening in the rod connector.
US08469995B2 Blood vessel closure clip and delivery device
A clip for closing a puncture in a body lumen comprises a clip having a resiliently expandable circumference and a plurality of barbed prongs extending at least approximately in the same direction from one edge of the clip. A device for deploying such a clip is described. A method for deploying such a clip is also described.
US08469991B2 Apparatus for performing an electrosurgical procedure
An endoscopic forceps is provided and includes a housing having a shaft that extends therefrom. An end effector assembly is operatively connected to a distal end of the shaft and includes a pair of pivotably coupled first and second jaw members. One of the jaw members is movable relative to the other jaw member. A drive mechanism includes a driving structure in operative communication with a cam slot operably disposed on one of the first and second jaw members. The driving structure includes a detent.
US08469990B2 Vein filter
A vessel filter comprising a first region and a second region wherein the filter is movable between a collapsed position for delivery to the vessel and an expanded position for placement within the vessel. A first region has a filter portion having a converging region to direct particles toward the center of the filter and the second region is flared in the expanded position to have a transverse dimension increasing toward a second end portion opposite the first end portion. The second region includes a vessel engaging portion at the second end portion. The first region includes a plurality of spaced apart elongated struts with adjacent struts being joined and a spacer extending radially with respect to a longitudinal axis of the filter.
US08469987B2 Split sheath for trocar assembly
A trocar assembly including a trocar and a trocar sheath and methods for accessing an intracorporeal site, e.g. biopsy or trocar site, using the trocar assembly. The trocar has a tissue penetrating distal tip, an elongated shaft and a proximal handle portion. The distal portion of the trocar sheath forms a releasable connection, such as a friction fit, with the shaft of the trocar and a slit that extends from the distal portion to the proximal end of the trocar sheath. The trocar assembly is advanced through the patient's tissue until the distal end of the trocar sheath is located at the desired site and then the trocar is removed. A treatment device such as a radiation balloon catheter is advanced through the interior of the sheath until the treatment component thereof is at the desired site.
US08469986B2 Lancet device with combined trigger and cocking mechanism and method
Lancet device including a skin engaging end that includes a lancet opening through which a lancet needle may extend, a movably mounted holding member configured to receive a lancet, and a combined triggering and cocking system structured and arranged to move the holding member to a retracted position during a cocking phase and to cause the holding member to move to an extended position during a triggering phase. A method of puncturing a surface of skin using the lancet device includes disposing the skin engaging end against a user's skin and manually activating the combined triggering and cocking system. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.
US08469981B2 Rotatable cutting implement arrangements for ultrasonic surgical instruments
Over the years, a variety of different types of non-ultrasonically powered cutters and shaving devices for performing surgical procedures have been developed. Some of these devices employ a rotary cutting instrument and other devices employ a reciprocating cutting member. For example, shavers are widely used in arthroscopic surgery. These devices generally consist of a power supply, a handpiece, and a single-use end effector. The end effector commonly has an inner and outer tube. The inner tube rotates relative to the outer tube and will cut tissue with its sharpened edges. The inner tube can rotate continuously or oscillate. In addition, such device may employ a suction channel that travels through the interior of the inner tube. For example, U.S. Pat. No. 4,850,354 to McGurk-Burleson, et al., discloses a non-ultrasonically powered surgical cutting instrument that comprises a rotary cutter for cutting material with a shearing action. It employs an inner cutting member which is rotatable within an outer tube.
US08469980B2 Methods and devices for preparing and implanting tissue scaffolds
Methods and devices are provided for preparing and implanting tissue scaffolds. Various embodiments of scribing tools are provided that are configured to mark one or more predetermined shapes around a defect site in tissue. The shape or shapes marked in tissue can be used to cut a tissue scaffold having a shape that matches the shape or shapes marked in tissue. In one embodiment, the scribing tool used to mark a shape in tissue can also be used to cut the tissue scaffold.
US08469978B2 Gastric bypass band and surgical method
An inventive method for performing gastric bypass surgery and a gastric bypass band that is used in conjunction with the surgical method is disclosed. The inventive method involves separating a top portion of the stomach along with the esophagus from the remainder of the stomach, and re-connecting the separated portion to the small intestine to form a gastric pouch of about 20-30 cc in size. The inventive gastric band is placed midway along the gastric pouch to act as a restrictor valve to limit the amount of food passing through the valve. The band also retains food within the gastric pouch to give the patient a feeling of satiety. The band is comprised of an expansion-resistant section combined with a one-way latch mechanism. The latch has a curved orientation so that the band is formed into a radial profile when placed around the gastric pouch.
US08469972B2 Methods and devices for reducing gastric volume
The present invention involves new interventional methods for reducing gastric volume, and thereby treating obesity. The procedures are generally performed laparoscopically and may generally be described as laparoscopic plication gastroplasty (LPG) in which, after obtaining abdominal access, spaced apart sites on a gastric wall are engaged, approximated and fastened to create one or more tissue folds forming one or more plications projecting into the gastrointestinal space. The serosal tissue may optionally be treated during the procedure to promote the formation of a strong serosa-to-serosa bond that ensures the long-term stability of the tissue plication. These procedures are preferably carried out entirely extragastrically (i.e. without penetrating through the gastrointestinal wall), thereby minimizing the risks of serious complications.
US08469971B2 Stylet for guiding leads of implantable electric stimulation systems and methods of making and using
A lead assembly includes a lead and a stylet. The lead has a distal end, a proximal end, and an outer lead covering. The lead includes a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and at least one lumen defined in the lead that extends from the distal end to the proximal end. The lead also includes a plurality of conductive wires electrically coupling the plurality of electrodes to the plurality of terminals. The stylet is configured and arranged for inserting into one of the at least one lumens of the lead. The stylet includes an elongated body and a protective feature that is coupled to the elongated body. The protective feature is configured and arranged for absorbing or redirecting an amount of force applied to the stylet above a threshold amount of force.
US08469965B2 Tool for detecting planes of a bone and assigned data processing method
The present application relates to a tool for detecting planes which are defined by anatomical landmarks, comprising a first and a second level abutment area for placing onto a body structure, wherein the first and second abutment areas have a predetermined position relative to each other, and comprising a tool marker device which has a stationary position relative to the first and second abutment areas.
US08469962B1 Prosthetic socket alignment
Methods, systems and devices for properly positioning and aligning a prosthetic socket into a bone cavity of a patient. The methods involve placing a guide piece, in bone that is close to the bone cavity, according to the position and alignment of a trial prosthetic socket previously fitted in a desired position and alignment in the bone cavity and then, after removing the trial, positioning and aligning the prosthetic socket in the bone cavity using the guide piece's position and alignment for guidance. A tilt sensing device is used to show the tilt or angle of devices used in the positioning and alignment procedure.
US08469959B2 Bone preparation device
A bone preparation device for shaping endplates forming an intervertebral disc space between two adjacent vertebrae includes a cutter component and a cutter-positioner component. The cutter-positioner is arranged to limit the distal travel of the cutter component and to restrict the range of motion of the distal end of the cutter component. The bone preparation device also includes a rotational interface between the cutter component and the cutter-positioner component. The rotational interface is structurally arranged to permit the cutting blade to be rotated at the same time the cutter component is restricted in its range of motion.
US08469958B2 Fixing block and method for stabilizing bone
A system is provided for stabilizing bone. The system includes a fixing block, a pin having a far end which is adapted to be fixed directly into bone and a near end which enters the fixing block, and a frame on which the fixing block is fixable. The pin enters the fixing block in a non-orthogonal manner in order to permit the pin to enter the bone with an orientation which is non-orthogonal to the bone's surface, thereby permitting the pin to engage more of the bone.
US08469952B2 System and method for positioning an eye therapy device
A system for aligning an eye therapy instrument over a selected area or feature of an eye provides an attachment element that is removably attached to a surface of an eye. A receiving element is coupled to the attachment element and movable relative to the attachment element. The receiving element includes a coupling element configured to operably couple an eye therapy instrument to the receiving element and adjustably move the eye therapy instrument into a selected position with respect to the attachment element. The system makes adjustments to ensure accurate delivery of treatment from the eye therapy device to areas of the eye. In one embodiment, the receiving element allows lateral adjustments to be made along one or more axes. Additionally or alternatively, the receiving element allows angular or rotational adjustments to be made about one or more axes.
US08469950B2 Intra-atrial apparatus and method of use thereof
An intra-atrial ablation therapy apparatus is disclosed. The apparatus comprises a balloon adapted for intra-atrial inflation to fill at least part of the atrium, the balloon being adapted to permit a flow of blood from a pulmonary vein to a mitral valve when inflated in the atrium. The apparatus further comprises an inflation lumen being in fluid communication with the balloon and adapted for conducting an inflation fluid to the balloon. The apparatus also comprises an ablation tool connected to the catheter.
US08469946B2 Operation unit and treatment tool for endoscope provided with the same
An operation unit of a treatment tool for an endoscope includes a first joining member configured to be joined to a rear end of a flexible sheath of the treatment tool, a second joining member configured such that the first joining member is fitted therearound rotatably around an axis line of the first joining member relative to the second joining member, and a pin fit hole formed between the first joining member and the second joining member such that a pin is fitted therein, the pin fit hole being configured to restrict rotational movement of the first joining member around the axis line relative to the second joining member when the pin is fitted in the pin fit hole.
US08469944B2 Introducer access assembly
An elongated introducer access assembly 2 comprising a distal end 4 and a proximal end 6, and provided with a first tubular channel 8 having a longitudinal axis 10 and running from a first proximal end opening 12 to a distal end opening (14) of the assembly and being adapted to receive a first tubular medical device. The assembly is provided with a second tubular channel 16 having a second proximal end opening 18 and running from the proximal end of the assembly. The second tubular channel being arranged in an angled direction in relation to the longitudinal axis of the first tubular channel, and that the second tubular channel enters the first tubular channel at a junction (20) proximally to the distal end of the assembly, and that an intersectional angle (α) is formed between the first tubular channel and the second tubular channel. The assembly further comprises a cutting unit 22 adapted to provide an opening cut through a part of a first tubular medical device arranged in said first tubular channel such that a second tubular device may be inserted into said second tubular channel and into the first tubular medical device via said opening cut.
US08469941B2 Intracranial catheter
A catheter having an outer profile which is formed such that a path length along an outer surface of the catheter is greater than the corresponding length of the catheter, and to a method for determining the shape of a catheter, and wherein the elasticity and/or conductivity of the tissue into which the catheter is to be introduced is taken into account in order to determine the outer profile of the catheter.
US08469940B2 Systems and methods for safe medicament transport
A medicament transport system includes a syringe adapter assembly; and a vial adapter assembly including a base defining an opening having a seal member disposed therewithin, a stem extending from the base and defining a lumen therethrough and an opening through a wall thereof, a needle shuttle valve slidably disposed within the lumen of the stem and supporting a transfer needle and a vacuum needle; and a vacuum cup slidably supported on the stem, wherein a vacuum chamber is defined in the space between the base, the stem and the vacuum cup. The medicament transport system includes a condition where the transfer needle and the vacuum needles penetrate the seal member of the vial adapter assembly, and the vacuum cup is moved to draw a vacuum through the vacuum needle. An automation system is provided that utilizes a medicament transport system for forming a medicament solution from a liquid/non-liquid solution.
US08469939B2 Vial adaptor
A vial adaptor configured to be attached to a wide range of vial sizes, the adaptor being configured to penetrate the vial seal so that the contents of a vial can be removed. The vial adaptor can have a body portion, a penetrating portion projecting from the body portion and configured to be inserted through the seal and positioned within an interior space of the vial so that the contents of the vial can flow through an opening in the penetrating portion, an interface portion supported by the body portion that is connectable to a syringe or other medical implement, at least one deflectable tab configured be bendable by hand or to bend in response to contact with the vial. The vial can also have a filtered air vent to allow air to fill the vial as the contents thereof are being removed.
US08469938B2 Process of fusion-bonding plastic film and drug bag
The present invention relates to a process of fusion-bonding a plastic film (8a, 8b) to an object to be fusion-bonded such as a port member (16) in manufacturing a drug bag, and relates to a drug bag. The present fusion-bonding process comprises steps of disposing a heat generation element generating heat by absorbing infrared laser, on an opposite surface (8c) of the plastic film (8a, 8b) from the port member (16), or between the port member (16) and the plastic film (8a, 8b), pressing a press member (30a, 30b), which allows infrared laser to be transmitted therethrough, from a side of the plastic film (8a, 8b), and irradiating the infrared laser (L) to the heat generation element (24a, 24b) through the press member (30a, 30b).
US08469936B2 Reduced-pressure dressings, systems, and methods employing desolidifying barrier layers
Reduced-pressure medical dressings, systems, and methods involve a dressing with a first barrier layer that desolidifies when exposed to a fluid—typically a liquid—to form a treatment aperture in the first barrier that is used to deliver reduced pressure to a tissue site. The first barrier layer is formed from a desolidifying material. The system includes a drape covering a second surface of a manifold and a portion of the patient's epidermis to provide a substantially sealed space containing a manifold and the first barrier layer. Other systems, dressings, and methods are also disclosed.
US08469929B2 Infusion set
A device for inserting a cannula into tissue, including a cannula, a protective element which can accommodate said cannula, an operating element for moving the cannula out of the protective element, and a holder fixedly connected to the cannula. The invention encompasses a system for connecting a liquid supply to the cannula.
US08469928B2 Systems and methods for providing a flushable catheter assembly
A flushable catheter assembly having features to enable selective activation of fluid flow through the catheter assembly is disclosed herein. A septum is placed within the catheter adapter of the catheter assembly and includes a pathway that is closed prior to being biased open via a septum activator also positioned within the catheter adapter. A plurality of air vent channels is interposed between the septum and the inner surface of the catheter adapter to permit “flashback” of blood during insertion of the catheter into a patient. The septum activator is advanced through the pathway of the septum as a coupler is attached to a proximal opening of the catheter adapter.
US08469924B2 Method and apparatus for generating vascular treatment foam
Apparatus and methods for generating foam are disclosed. The inventions can be used for generating foam for sclerotherapy. A foaming element can be agitated within a foaming chamber by a drive unit that does not touch the foaming element, but actuates it from outside the foaming chamber. The foaming element and drive unit can be magnetically coupled. A syringe can be used to form a foaming chamber.
US08469919B2 Apparatus and methods for uniformly distributing coolant within a cryo-ablation device
Apparatus and methods for uniformly distributing coolant within a cryo-ablation device. A nozzle apparatus includes a tubular member having a plurality of angled apertures that induce swirling of coolant streams dispersed through the angled apertures. Coolant swirling round the tubular member and along an inner surface of an inflatable balloon element inflates the balloon element and cryogenically ablate tissue. The swirling action achieved using angled apertures uniformly distributes coolant along the inner surface of the balloon such that the temperatures along an inner surface of the balloon element and ablation of tissue adjacent to the balloon element are substantially uniform.
US08469917B2 Insertion device for infusion sets
An insertion device for infusion sets, including a housing for generally enclosing an infusion set placed in the insertion device and a drive device for displacing the infusion set, wherein the displacing is as friction-free as possible with respect to the housing.
US08469914B2 Compression device
The invention relates to a compression device and particularly a compression device provided with fastening means to provide an adjustability of the circumference enabling controllable compression of the device. In particular, present invention relates to a compression device or legging with fastening means comprising a tongue with multiple zip fasteners.
US08469913B1 Injured limb protector
An injured limb protector (10) includes a pad (11), a tubular pad cover (12) surrounding the pad, and a tubular sleeve (13). The pad is a dual density material having an outer layer (16) which is made of a high density material bonded to an inner layer (17) which is made of a low density material. The outer layer is scored or cut to allow manipulation of the pad to conform to an elbow or heel. The pad includes a central portion (19), two oppositely disposed end flaps (22) and two oppositely disposed side flaps (23), which allow it to be formed into a cup-shaped pad. The sleeve is provided with a visible alignment line (26) oriented longitudinally upon the one side (15) of the sleeve to which the pad is mounted.
US08469911B2 Surgical positioning system
A surgical positioning system includes a flexible air-impermeable shell filled with beads that is wrapped against the patient and subjected to a vacuum to hold the patient in place. The shell includes rounded shoulder portions, on either side of a separately inflatable pillow, to envelop portions of the patient's neck and shoulders, tapered waist portion to provide easy access to a patient's forearms and lower lateral abdomen, and expanded wrist hand portion to cradle the patient's hands and thighs.
US08469910B2 Pneumatic compression garment with noise attenuating means
A pneumatic compression garment comprises a flexible member for placement on a limb of a human body. A bladder in the flexible member defines an inflatable chamber. The bladder has an opening through which the inflatable chamber is inflated. A port mounted on the bladder has an air inlet adapted for communication with a source of pressurized air and an air outlet in communication with the inflatable chamber via the opening in the bladder. Pressurized air is delivered from into the inflatable chamber for inflating the inflatable chamber and thereby applying a compression force to the limb when the flexible member is in place on the limb. Noise attenuating means associated with the bladder opening is provided for reducing noise from air flow through the opening into the inflatable chamber.
US08469909B2 Motor for a personal skin care appliance
The motor includes a rigid anchor member which is fixedly mounted to the applicator housing, an electromagnetic stator member and an armature. The armature includes a permanent magnet assembly and two leaf springs which connect the anchor member and the armature, the leaf springs being positioned at right angles to each other. The ratio of the lengths of the spring members is within the range of 0.75:1 to 0.95:1. A driving assembly produces an alternating current drive signal to the stator member which moves the armature and a skin contact member attached thereto in a reciprocating motion which includes a first component perpendicular to the skin, a second component parallel to the skin and a third arcuate component.
US08469908B2 Analgesic implant device and system
An implant system for imparting vibratory massage to tissue of a patient from within the body of the patient is disclosed. The system comprises an implant device configured to produce and communicate a vibration to body tissue located adjacent to the implant device. The device may include a case forming at least a portion of an exterior of the device, and a vibration generator configured to vibrate the portion of the exterior. The device may include a power supply to supply power to the vibration generator and a switch to selectively permit power from the power supply to be supplied to the vibration generator. The device may include a power receiver to receive electrical energy from a location external to the body of the patient and a signal receiver to receive signals from a location external to the body of the patient when the receiver is located in the body of the patient.
US08469903B2 Ultrasonic treatment apparatus and program
An ultrasonic treatment apparatus according to the present invention includes: an oscillation unit which selectively oscillates a plurality of ultrasonic signals; a data table which includes a plurality of data rows storing in advance frequency data of the ultrasonic signals, at least one data row among the plurality of data rows storing specific frequency data and other frequency data such that a storage amount of the specific frequency data is larger than that of the other frequency data; an operation unit which select one application data row from the plurality of data rows: a plurality of ultrasonic oscillators which include a plurality of resonance frequencies: a plurality of connectors to which the plurality of ultrasonic oscillators are each connectable; a plurality of switches which are each connected, to the plurality of connectors; and a control unit which, in order to apply an application ultrasonic signal selected based on the application data row among the plurality of ultrasonic signals to one application ultrasonic oscillator among the plurality of ultrasonic oscillators, controls the plurality of switches so as to selectively apply the application ultrasonic signal to an application connector connected to the application ultrasonic oscillator, among the plurality of connectors.
US08469900B2 Allergy testing device and method of testing for allergies
An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has at least one touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activators to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and/or discomfort during testing.
US08469898B2 Indication-based worsening HF alert
This document discusses, among other things, receiving a user selection of a heart failure symptom, receiving a user selection of an abnormal psychological condition, receiving information about a physiological patient status parameter, and determining a heart failure status using the received information.
US08469894B2 Ultrasonic probe and ultrasonic diagnostic device
An ultrasonic probe includes at least one transmission element layer for transmitting ultrasonic waves, at least one reception element layer for receiving ultrasonic waves and which is provided with an electrode on each of both surfaces opposed in a thickness direction thereof, and at least one matching layer for matching acoustic impedance. These layers are arranged in this order in a direction of transmitting the ultrasonic waves. An upper layer and a lower layer each sandwiching the electrodes formed on both surfaces of the reception element layer are each provided with a projecting portion which projects from the reception element layer in a direction of elevation. At least one of the electrodes formed on the reception element layer is formed by extending on a surface of one of the projecting portion opposed to a respective one of the upper layer and the lower layer.
US08469890B2 System and method for compensating for motion when displaying ultrasound motion tracking information
A system and method for compensating for motion with displaying ultrasound motion tracking information are provided. The method includes obtaining ultrasound image data of an imaged object and determining motion tracking information based on the ultrasound image data. The method further includes compensating for motion of the imaged object based on the determined motion tracking information and generating motion compensated ultrasound image data in combination with motion tracking indicators based on the motion compensation.
US08469886B2 Signal processing for continuous analyte sensor
Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.
US08469883B2 Surgical access device comprising internal retractor
Devices, methods, and systems provide a surgical access device comprising an internal retractor device integrated with or coupled to a body wall or wound retractor. The wound retractor retracts an opening in a body wall into a body cavity, while the internal retractor permits a user to control the positions of internal structures within the body cavity, thereby permitting a user to define a surgical field. Embodiments of the internal retractor are adjustable.
US08469882B2 Digital otoscope
An otoscope includes an instrument head, a tip element and an optical system. The instrument head has a distal insertion portion for insertion into an ear of a human or veterinary subject. The distal insertion portion has a distal opening. The tip element is releasably attached to the distal insertion portion. The tip element has a distal opening. The optical system is contained within the instrument head. The optical system includes a plurality of optical components. The optical system further comprises a viewing component for viewing of an image of a target of interest aligned along an optical axis disposed within said distal opening.
US08469876B2 Endoscopic devices and method of use
A catheter including a shaft comprising a body with a proximal portion and a distal portion, the body defining an opening from the proximal portion to the distal portion, the distal portion having an end that is beveled in a first direction across an end opening, such that a length of the shaft to a first point on the end is a first length and a length of the shaft to a second point on the end is a second length longer than the first length. A method including placing at least one embryo near an open end of a catheter, inserting the open end of the catheter into an endometrial lining of a subject's uterus, using the catheter to open a flap of the endometrial lining, and transferring the at least one embryo from the catheter to the pocket site.
US08469874B2 Heart help device, system, and method
An implantable device for improving the pump function of the heart of a human patient by applying an external force on the heart muscle is provided. The device comprises at least one pump device having a pump. The pump comprising: a piston adapted for reciprocating movement, an operating device for operating the piston, a heart contacting organ. The movement of the piston assists the pump function of the heart through said heart contacting organ.
US08469872B2 Magnetic therapy device
A magnetic therapy device may include a housing, a disk, a tachometer, a microprocessor, a driver integrated circuit, and a plurality of coils. The disk may include a plurality of magnets thereon, the disk being mounted inside the housing and configured to rotate within the housing. The tachometer may be configured to monitor a magnetic field generated by the plurality of magnets and provide a frequency signal to a microprocessor based on the monitored magnetic field. The microprocessor may be configured to provide a control signal to the driver integrated circuit based on the frequency signal, the microprocessor being programmed to provide the control signal to maintain a constant speed of rotation of the disk based on the frequency signal. The driver integrated circuit may be configured to provide a current to a plurality of coils based on the control signal. The plurality of coils may be configured to generate, based on the current received from the driver integrated circuit, a magnetic field which will generate a force on the plurality of magnets and thereby cause the disk to rotate.
US08469871B2 Centrifuge
Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.
US08469869B2 Apparatus and method for folding article
An apparatus for folding articles advancing in a machine direction including a rotatable roll having a roll surface, at least one protrusion that defines an outermost surface of the roll and at least one pocket that defines an innermost surface of the roll. The apparatus also includes a first and second vacuum conveyor assembly, each comprising two vacuum conveyors. The roll and the vacuum conveyor assemblies are cooperatively configured to fold an article.
US08469866B2 Wheelchair gym
A wheelchair gym having a support bar releasably connected to the frame of the wheelchair. A vertical post is attached to the support bar and hand grips are slidably mounted on the vertical post. The hand grips are resiliently biased and may be moved conjointly or opposite to one another to provide arm exercise for a patient in the wheelchair. The gym also has leg supports on which resiliently biased foot rests may be moved conjointly or opposite to one another. The leg supports may be moved up and down or may be splayed laterally.
US08469864B2 Exercise device having inelastic straps and interchangeable parts
An exercise device having an anchor with multiple components is described. In one embodiment, the anchor includes one or more interlocking components, such as rigid or flexible loops. Rigid loops such as gated rings may advantageously be used to connect the different components. Embodiments permit for replacing, interchanging, or adding components to an exercise device anchor.
US08469859B2 Control apparatus for hybrid vehicle
In a hybrid vehicle having a locking mechanism in which a play elimination process is required in the locking, a torque shock in the play elimination is reduced. In a hybrid vehicle 1 having a locking mechanism 700 which is a cam-lock type engaging apparatus, an ECU 100 performs MG1 locking control. In the control, play is formed between a cam 710 and a clutch plate 720 of the locking mechanism 700. The formed play is gradually reduced such that the torque shock in the play elimination does not occur due to the phase control of the cam 710, on the basis of an initial value of the amount of the play when the clutch plate 720 is bought into contact with a friction part 733 and a play elimination amount G.
US08469857B2 Vehicle and control method and control device for vehicle
An ECU controls SOCs of a master battery and a sub battery so that the SOCs vary within the range of a predetermined upper limit value and lower limit value. A control is made so that the SOC of the sub battery is lower than the SOC of the master battery when the condition that execution of charging with electric power supplied from the source external to a plug-in hybrid vehicle is predicted is satisfied.
US08469853B2 Continuously variable transmission
A variable speed transmission having a plurality of tilting balls and opposing input and output discs is illustrated and described that provides an infinite number of speed combinations over its transmission ratio range. The use of a planetary gear set allows minimum speeds to be in reverse and the unique geometry of the transmission allows all of the power paths to be coaxial, thereby reducing overall size and complexity of the transmission in comparison to transmissions achieving similar transmission ratio ranges.
US08469851B2 Oil supply system for an automatic transmission of a vehicle, an automatic transmission and a vehicle comprising the oil supply system
An oil supply system is provided for an automatic transmission of a vehicle that includes, but is not limited to a valve body and an electric oil pump. The valve body houses a plurality of hydraulic pressure control valves to control main pressure, torque converter and gear shifts of the automatic transmission. The valve body is in flow communication with an oil pan. The electric oil pump is driven by an electric supply and is configured to pump oil into the automatic transmission via the plurality of hydraulic control valves. The electric oil pump is positioned within the valve body or within the oil pan.
US08469850B2 Superposition transmission
A superposition transmission in several variants and embodiments has hydrostatic-mechanical or electric-mechanical power splitting for the use in vehicles and work machines such as municipal vehicles, handling devices such as telehandlers or forklifts, wheel loaders, tractors and comparable apparatuses, in which an infinitely variable adjustment of the gear ratio is desired independent of the speed of the drive engine. The input shaft (1) is connected with a variator which is in operative connection with two summing planetary gears (12) and (13) arranged parallel with respect to each other. The output occurs in all driving speeds and all driving ranges via the planet carrier arranged as carrier (18).
US08469849B2 Hybrid vehicle system and controller
A system for operating a hybrid vehicle that includes a chargeable energy storage device, a single dynamo (motor/generator combination) an internal combustion engine, and a torque coupling device configured to variably couple the engine to the dynamo. The torque coupling device is such that using only a single dynamo, the system is able to operate in different modes expected of hybrid vehicles, such as: electric drive only, engine drive only, electric and engine drive combined, and charging of the chargeable energy storage device.
US08469848B2 Vehicular drive apparatus
In a drive apparatus in which a first motor-generator, a power split device, a shift mechanism, and a second motor-generator are coaxially arranged, a first support wall which is next to the second motor-generator and supports one end of a rotor, and a second support wall that supports the other end of the rotor are provided in a case. A switching portion of the shift mechanism is provided on the first support wall. This kind of structure enables the drive apparatus to be shorter in the axial direction.
US08469842B2 Expandable arrowhead or broadhead
An expandable arrowhead having a blade-carrying body with a slot that houses at least one movably mounted blade. Each blade can be pivotally mounted about a shaft. In some embodiments, the shaft is fixed with respect to the body. In other embodiments, the shaft is movably mounted with respect to the body, for example by mounting a shaft within the slot so that the shaft moves within the slot with respect to the blade-carrying body. In some embodiments of this invention, a spring element positively holds one or more blades in a closed position or a retracted position, particularly during extreme forces encountered when launching an arrow from an archery bow, such as a compound archery bow. The spring element of this invention can be used to improve blade opening capabilities of conventional blade-opening arrowheads or broadheads.
US08469837B2 Color golf ball
The invention provides a colored golf ball composed of a core, a cover having a plurality of dimples formed on an outside surface thereof, and an inside layer in contact with the cover. The ball satisfies the following conditions: (i) a color difference ΔE* between the inside layer and the ball of at least 30; (ii) the inside layer has a lightness L* value, expressed in the L*a*b* color system based on JIS Z8729, of at least 82; (iii) the ball has a lightness L* value of at least 50; (iv) the lightness L* value of the ball≦the lightness value of the inside layer; (v) the inside layer has a transparency which is up to 10% in terms of total transmittance and up to 1.0% in terms of parallel transmittance; (vi) the cover has a transparency which is at least 50% in terms of total transmittance and at least 1.0% in terms of parallel transmittance; and (vii) the inside layer has a haze (H), mentioned in JIS K7105 (1981), of at least 90. The colored golf ball of the invention is a fluorescent ball, yet retains a sense of transparency and thus confers a sense of quality. The ball also has weather resistance and is able to prevent changes in color. Moreover, the golf ball of the invention has a reassuring and psychologically calming effect on the golfer during play, and has a suitable look and feel.
US08469834B2 Golf club head
A golf club head having a hollow construction includes a face part having a ball-impacting surface and a first main rib and a second main rib disposed on the inner surface of the face part. The first main rib extends from a crown side to a sole side, and the second main rib extends from a hosel side to a toe-side part of the sole side, the first and second main ribs intersecting each other. The material thickness on a toe side of the face part, with the first main rib being the boundary, is formed so as to be thinner than the material thickness on a heel side of the face part.
US08469830B2 Universal joint
A universal joint includes a pivotal member and two connecting assemblies. The two connecting assemblies are assembled to two ends of the pivotal member, respectively, such that the two connecting assemblies are rotatably assembled together via the pivotal member. The pivotal member defines four arc-shaped pivotal slots spaced to each other at an outer periphery thereof. Each connecting assembly includes two connecting members respectively assembled to the two symmetrical pivotal slots of the pivotal member, and are positioned at a same end of the pivotal member.
US08469828B2 Elastic joint body
An elastic joint body for a shaft arrangement for the articulated connection of two shaft sections is provided, with a plurality of bushings arranged in the circumferential direction at predetermined angular distances with respect to a center axis of the joint body, a plurality of loop bundles, each loop bundle looping around in each case two adjacent bushings, and a rubber-elastic casing in which the loop bundles and the bushings are at least partially embedded. A flange is provided at least one end region on at least one of the bushings for the axial support of an adjacent loop bundle, encircling the bushing, being at least partially embedded in the rubber-elastic casing and having a U-shaped cross-section, as viewed in the axis-containing section, the cross-section being designed with two U longitudinal limbs and one U transverse limb, the flange bearing with a U longitudinal limb against the bushing.
US08469827B2 Torque fluctuation absorber
A torque fluctuation absorber includes a seating member having a pivoting portion at an inner portion in a radial direction and a supporting portion, which rotationally supports the pivoting portion, at an end surface in a circumferential direction of a first and a second opening portion. When no relative rotational torsion existing between a first and a second rotational member, the pivoting portion is in contact with the supporting portion and a clearance is defined between a portion on each seating member positioned outwardly in a radial direction relative to the pivoting portion and a portion of the first and the second opening portion positioned outwardly in a radial direction relative to the supporting portion. At a first torsion angle, the portion on each seating member contacts the portion of first or second opening portion in a state where the pivoting portion is in contact with the supporting portion.
US08469825B2 Elastic coupling
An Elastic Coupling (1) has a pair of bodies (2,3) that can rotate about a common axis and are mutually associated by a plurality of springs (7). Each spring has an end associated with the other body; the ends of the springs are associated with the bodies by floating engagement means (8). The floating engagement means arc provided by mating spherical surfaces between the spring and the seats (6) and allows to recover the misalignment cased by the variation of the distance between the seats, limiting the stresses and allowing the spring to work exclusively in an axial direction, without warping, contrary to conventional spring couplings, wherein the springs are inserted in simple cylindrical seats and must necessarily warp.
US08469823B2 Method and apparatus for generating special effects
Systems and methods for generating special effect are provided. In one embodiment, the method includes: receiving an input information from a game controller; generating an output data set based on the input information received by the game controller at a game console; transmitting the output data to a stage kit; and generating special effects at the stage kit based on the output data received from the game console.
US08469815B2 Video game accessory
A video game accessory comprises a body configured to receive a video game controller at a first location of the body, receive a controller expansion device connectable to the video game controller at a second location of the body, and maintain the orientation of the controller expansion device so that the orientation of the controller expansion device is substantially fixed with respect to an orientation of the video game controller, and a pass through cable comprising a first end that includes a first connector and a second end that includes a second connector, the pass through cable extending from the first location to the second location, wherein the first connector is engageable with a first mating connector of the video game controller and the second connector is engageable with a second mating connector of the controller expansion device.
US08469810B2 Storage medium having game program stored thereon and game apparatus
Reference coordinates in a coordinate system and designated coordinates based on coordinate information outputted by a pointing device are provided, and a distance between the reference coordinates and the designated coordinates is calculated. When a first mode is selected, a calculated distance is converted into a predetermined parameter using a first conversion function. On the other hand, when a second mode is selected, a calculated distance is converted into a parameter using a second conversion function. According to whether the first mode is selected or the second mode is selected, a game is processed based on the aforementioned parameter.
US08469809B2 Game apparatus, storage medium storing game program and game controlling method
A game apparatus includes an LCD, and a touch panel is placed on a top surface of the LCD. A player instructs an enemy character displayed on the LCD by use of a stick to attack the enemy character. For example, in a case that the enemy character exists at a depth of a game screen, little damage is applied to the enemy character, and a weak vibration is applied to the game apparatus. Conversely, in a case that the enemy character exists at a front of the game screen, much damage is applied to the character, and a strong vibration is applied to the game apparatus. In either case, the vibrations are transmitted to the fingers or hands of the payer via the stick.
US08469805B2 Tiered achievement system
A game console has the capability to execute programming to unlock an achievement. After the achievements are unlocked, a data store accessible by the game console over a network stores the information in the profile of the user. The achievements associated with the user profiles can be retrieved from the store along with an indicator, that is indicative of a tier level associated with the achievement where the tier indicates a certain performance level associated with unlocking a particular achievement.
US08469796B2 Gaming machine and method with a plurality of formats
A gaming system comprises a game controller and a memory storage device comprising game data, the game controller and the memory storage device being arranged such that the game controller can process the game data to effect play of a game. In this gaming system, the play of a game comprises selecting a plurality of symbols and presenting the selected symbols in a plurality of symbol positions that are generally arranged in a plurality of columns, to provide a plurality of game combinations, and wherein the game play comprises a first game component in the form of a line game and a second game component in the form of a game in which for at least one column a plurality of the display positions are designated and the combinations of the game include every possible combination of the designated symbol positions when taking one designated symbol position from each column and wherein less than all of the symbol positions are designated.
US08469794B2 Gaming controller, a gaming system, and a method of gaming
A method of gaming comprising: a) displaying a plurality of display positions to a player, at least one of the display positions corresponding to a hidden object to be sought by the player; b) determining a selection of a display position; c) revealing whether or not the selected display position corresponds to the hidden object; e) determining whether to allow a selection by conducting at least one trial, each trial comprising seeking to complete a symbol combination; and f) repeating steps b) to e) until either the symbol combination is completed or a designated number of hidden objects is located.
US08469793B2 Gaming apparatus and method including hidden objects
A method of game play, where a plurality of graphic objects are displayed on the display (106), each graphic object being operable to present one or more symbols. A subset of the graphic objects (604, 606, 608, 610) are activated to present symbols on the display, and at least one remaining graphic object (602) is obscured during the activation. The remaining graphic object (602) is revealed if a combination of symbols presented on the activated subset matches an eligibility criterion, and the revealed graphic object (602) is activated to present one or more symbols. An award is awarded if the symbols displayed on the graphic objects match a specified winning criterion.
US08469791B2 Method of playing a bingo-type game with a mechanical technological aid, and an apparatus and program product for playing the game
A method of playing a bingo-type game includes the steps of generating a result of the game and displaying a representation of the result. More specifically, the representation of the result of the game is displayed through a mechanical technological aid at an electronic play station. An apparatus for playing the game includes a server and the electronic play station in operative communication with the server. The server generates the called numbers, which correlate to the result of the game, and the electronic play station includes the mechanical technological aid for displaying the representation of the result of the game. A program product for playing the game is stored on computer readable media and includes a result program code for generating the result of the game and a display program code for displaying the representation of the result through the mechanical technological aid.