Document Document Title
US08420836B2 NFAT signal inhibitor and hair-growing agent
An NFAT signal inhibitor and the like are provided.An NFAT signal inhibitor and the like, containing, as an active ingredient, at least one compound selected from the group consisting of a coumarin derivative represented by formula [where in the formula (I), R1 and R2, which may be identical with or different from each other, each represent a hydrogen atom or a group represented by formula (II) (where in the formula (II), R3 represents a linear or branched alkyl or alkenyl group having 1 to 20 carbon atoms)] and pharmacologically acceptable salts thereof.
US08420833B2 Producing biofuels using polyketide synthases
The present invention provides for a non-naturally occurring polyketide synthase (PKS) capable of synthesizing a carboxylic acid or a lactone, and a composition such that a carboxylic acid or lactone is included. The carboxylic acid or lactone, or derivative thereof, is useful as a biofuel. The present invention also provides for a recombinant nucleic acid or vector that encodes such a PKS, and host cells which also have such a recombinant nucleic acid or vector. The present invention also provides for a method of producing such carboxylic acids or lactones using such a PKS.
US08420831B2 Intermediates of 1-O-acyl-2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranoses
The present invention relates to a process for preparing 1-O-acyl-2-deoxy-2-fluoro-4-thio-β-D-arabinofuranoses having formula I and intermediates thereof: wherein R1 represents —C(O)—C1-C6-alkyl or —C(O)-aryl; and R2 represents C1-C6-alkyl, C1-C4-perfluoroalkyl or aryl.
US08420824B2 Substituted pyrazoles, compositions containing these, method of production and use
The disclosure relates to a compound of formula (I): and salts thereof; wherein Ar, L, A, X, R1, R2, R3, R4a, R4b, and R5 are as defined in the disclosure; compositions comprising said compounds, methods for their preparation, intermediates thereto, and the use thereof, particularly as drugs.
US08420823B2 Long-chain fatty acyl elongase inhibitor comprising arylsulfonyl derivative as active ingredient
[Problem] To provide compounds useful as preventives or remedies for circular system disorders, nervous system disorders, metabolic disorders, reproduction system disorders, digestive system disorders, neoplasm, infectious diseases, etc., or as herbicides.[Means for Solution] A long-chain fatty acyl elongase inhibitor comprising, as the active ingredient thereof, a compound or a pharmaceutically-active salt thereof of a formula (I): [wherein W represents a hydrogen atom, a C1-6 alkyl, etc.; X represents an aryl, a heteroaryl, etc.; n indicates 0 or 1; Z represents a hydrogen atom, a C1-6 alkyl, etc.; A1, A2, A3 and A4 each independently represent CH or N].
US08420821B2 Process for production of 4-oxoquinoline compound
The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, the present invention provides, for example, compounds represented by the formulas (6), (7-1), (7-2) and (8): wherein R is a fluorine atom or a methoxy group, R1 is a C1-C4 alkyl group, R2 is a hydroxyl-protecting group, and X2 is a halogen atom, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.
US08420820B2 Pyrrolopyridinylpyrimidin-2-ylamine derivatives
Compounds of the formula I in which X, R1, R2, R3, R4 and R6 have the meanings indicated in Claim 1, are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumours.
US08420817B2 Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof
The invention relates to tricyclic N-heteroaryl-carboxamide derivatives having the formula (I): Wherein A, P, W, Z1, Z2, Z3, Z4, Z5, Z6, Z7, Z8, R3 and R3′ are as described herein. The invention also relates to a method for preparing the same and to the therapeutic use thereof.
US08420816B2 Dihydropyrrolonaphthyridinone compounds as inhibitors of JAK
Disclosed are JAK inhibitors of formula I where G1, R1, R2, R3, R4, R5, R6, and R7 are defined in the specification. Also disclosed are pharmaceutical compositions, kits and articles of manufacture which contain the compounds, methods and materials for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions involving the immune system and inflammation, including rheumatoid arthritis, hematological malignancies, epithelial cancers (i.e., carcinomas), and other diseases, disorders or conditions associated with JAK.
US08420815B1 Anti-cancer agents based on N-acyl-2, 3-dihydro-1H-pyrrolo[2,3-b]quinoline derivatives and a method of making
The present disclosure relates to novel compounds that can be used as anti-cancer agents in the prostate cancer therapy. In particular, the invention relates to N-acyl derivatives of 2,3-dihydro-1H-pyrrolo[2,3-b]quinolines having the structural Formula (I), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof. The meaning of R1 is independently selected from H; C1-C6 Alkyl, cyclo-Alkyl or iso-Alkyl substituents; R2 is selected from C1-C6 Alkyl, cyclo-Alkyl or iso-Alkyl; substituted or non-substituted, fused or non-fused to substituted or non-substituted aromatic ring, aryl or heteroaryl groups. The invention also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.
US08420809B2 Process for the manufacturing of betamimetics
The present invention relates to a process for preparing betamimetics of formula 1, wherein n denotes 1 or 2; R1 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R2 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R3 denotes hydrogen, C1-4-alkyl, OH, halogen, O—C1-4-alkyl, O—C1-4-alkylene-COOH, O—C1-4-alkylene-COO—C1-4-alkyl.
US08420806B2 Process for the crystallisation of cefadroxil monohydrate
The present invention relates to a process for the preparation of cefadroxil in crystal form, comprising a) adding an aqueous solution of cefadroxil to a crystallization vessel and a titrant to keep a pH in the crystallization vessel of between 7 to 9; and b) lowering the pH in the crystallization vessel to a value of between 5 and 6.5 to obtain a suspension of the β-lactam compound in crystal form. The invention further relates to cefadroxil in crystal form obtainable by the process according to the present invention. The invention also relates to cefadroxil in crystal form with a CIE b value of below 12 when stored at a temperature of 25° C. for at least 1 month.
US08420805B2 Process for preparing prophyrin derivatives, such as protoprophyrin (IX) and synthesis intermediates
The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: R and R′ are as defined in claim 1, comprising: a step of condensation, in an acidic medium, between a dipyrromethane of formula (II): in which R′b is as defined above for (I), and a dipyrromethane of formula (III): in which R″ is as defined in claim 1, and also the compounds of formula (III).
US08420798B2 Method for producing nucleic acid probes
The present disclosure provides nucleic acid probes, as well as kits that include such probes. Methods for producing and using (for example in chromosomal in situ hybridization) the probes are also provided. Such probes in some examples are used to detect chromosomal abnormalities or the presence of a pathogen.
US08420795B2 Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof. The neuromodulatory agent has one or more of the following characteristics: it is capable of inducing remyelination; binding to neural tissue; promoting Ca++ signaling with oligodendrocytes; and promoting cellular proliferation of glial cells. Amino acid and DNA sequences of exemplary antibodies are disclosed. Methods are described for treating demyelinating diseases, and diseases of the central nervous system of humans and domestic animals, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, active fragments thereof and the like. The invention also extends to the use of human antibodies, fragments, peptide derivatives and like materials, and their use in diagnostic and therapeutic applications, including screening assays for the discovery of additional antibodies that bind to cells of the nervous system, particularly oligodendrocytes.
US08420794B2 Anti-influenza M2e antibody
Humanized recombinant and monoclonal antibodies specific for the ectodomain of the influenza virus M2 ion channel protein are disclosed. The antibodies of the invention have anti-viral activity and may be useful as anti-viral therapeutics and/or prophylactic/vaccine agents for inhibiting influenza virus replication and for treating individuals infected with influenza.
US08420791B2 Expression of FoxP3 by cancer cells
The present invention relates to the treatment, diagnosis, and prophylaxis of cancer based on the expression of foxp3.
US08420790B2 Efficient and scalable process for the manufacture of Fondaparinux sodium
The present invention relates to a process for the synthesis of the Factor Xa anticoagulent Fondaparinux and related compounds. The invention relates, in addition, to efficient and scalable processes for the synthesis of various intermediates useful in the synthesis of Fondaparinux and related compounds.
US08420788B2 Epitopes derived from SATB2 and uses thereof
The present invention relates to an affinity ligand capable of selective interaction with an epitope sequence consisting of 47 amino acids or less and comprising the amino acid sequence of SEQ ID NO:1 and/or SEQ ID NO:2. Further, it relates to a polypeptide consisting of the epitope sequence and to uses of the affinity ligand and the polypeptide.
US08420787B2 Organic compounds
The present invention relates to human thymic stromal lymphopoietin (hTSLP) antibodies and especially those which neutralize hTSLP activity. It further relates to methods for using anti-hTSLP antibody molecules in diagnosis or treatment of hTSLP related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease, and Hodgkin's lymphoma.
US08420786B2 Bispecific antibody targeting a complement factor or complement regulatory protein
A multispecific antagonist is disclosed that reacts specifically with at least two different targets. The targets are (A) proinflammatory effectors of the innate immune system, (B) coagulation factors, (C) complement factors and complement regulatory proteins, and (D) targets specifically associated with an inflammatory or immune-dysregulatory disorder or with a pathologic angiogenesis or cancer, wherein this latter target is not (A), (B) or (C). At least one of the targets is (C), and when the multispecific antagonist comprises a single multispecific antibody, then CD74 is excluded as a target of said antagonist. When the multispecific antagonist comprises a combination of separate antibodies, combinations are excluded where one of said antibodies targets a B-cell antigen and the other antibody targets a T-cell, plasma cell, macrophage or inflammatory cytokine and combinations are also excluded where one of said antibodies targets CD20 and the other antibody targets C3b or CD40.
US08420785B2 Soluble human ST-2 antibodies and assays
Provided herein are antibodies and antigen-binding antibody fragments that bind to human soluble Growth Stimulation-Expressed Gene 2 (ST2) protein, kits containing these antibodies and antibody fragments, and methods of using these antibodies and antibody fragments.
US08420783B2 Method and compositions for immunotherapy of inflammatory and immune-dysregulatory diseases
Methods and compositions for immunotherapy of inflammatory and immune-dysregulatory diseases, using multispecific antagonists that target at least two different markers are disclosed. The different targets include proinflammatory effectors of the innate immune system and targets specifically associated with an inflammatory or immune-dysregulatory disorder, wherein the targets included in the latter group are not a proinflammatory effector of the immune system. Thus, the multispecific antagonist contains at least one binding specificity related to the diseased cell or condition being treated and at least one specificity to a component of the immune system. The multispecific antagonists are used in the treatment of various diseases that are generated or exacerbated by, or otherwise involve, proinflammatory effectors of the innate immune system.
US08420781B2 Fluorescent protein
An object of the present invention is to provide a red or orange fluorescent protein, which is characterized in that the difference (stokes shift) between an excitation peak value (wavelength of maximum absorption) and a fluorescence peak value (wavelength of maximum fluorescence) is greatened, so that the maximum fluorescence can be obtained by the maximum excitation. The present invention provides a novel fluorescent protein monomerized by introducing a mutation into a florescent protein derived from Fungia sp., and a novel chromoprotein and fluorescent protein derived from Montipora. sp.
US08420778B2 Tripeptides and derivatives thereof for cosmetic application in order to improve skin structure
The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R1 represents H, —C(O)—R6, —SO2—R6 or —C(O)—XR6; R2 and R4, independent of one another, represent (CH2)n—NH2 or (CH2)3—NHC(NH)NH2; n equals 1 4; R3 represents linear or branched C1-C4 alkyl that is optionally substituted by hydroxy; R5 and R6, independent of one another, represent hydrogen, optionally substituted (C1-C24)alkyl, optionally substituted C2-C24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4 alkyl or 9-fluorenyl-methyl; X represents oxygen (—O—) or NH—; or XR5 with X═O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R1 and R5 do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).
US08420775B2 Polypeptides and methods for modulating D1-D2 dopamine receptor interaction and function
The present invention provides for prevention and/or treatment of neurological or neuropsychiatric disorders involving abnormal D1-D2 dopamine receptor coupling and/or activation. Methods and agents are provided for modulating dopamine receptor function arising from D1-D2 coupling and/or activation. Agents of the present invention include fragments of D2 receptor or D1 receptor that can disrupt D1-D2 coupling.
US08420774B2 Decorating hydroxyapatite biomaterials with modular biologically active molecules
A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a hydroxyapatite-binding portion and a biomolecule-derived portion. The modular peptides have improved non-covalent binding to the surface of the HA-based materials, and are capable of initiating osteogenesis, angiogenesis, and/or osteogenic differentiation.
US08420773B2 Process for producing water-absorbing polymer particles
A process for producing water-absorbing polymer particles, comprising polymerization of a monomer solution or suspension, drying the resulting polymer gel, and grinding and classifying the dried polymer gel, wherein the grinding is performed by means of a multistage roll mill, the first milling gap has a width of 500 to 5000 μm, the product mass flow passing through the first milling gap is conducted through a magnetic separator to the second milling gap, and the second milling gap has a smaller gap width than the first milling gap.
US08420771B2 PH-sensitive polyethylene oxide co-polymer and synthetic method thereof
Provided are a new pH-sensitive co-polymer prepared from polyethylene oxide and a method of preparing the same. The polyethylene oxide co-polymer includes repeating units expressed by the Chemical Formulas 1 and 2, and further includes at least one of repeating units expressed by the Chemical Formulas 3 through 6.
US08420763B2 Fluorooxyalkylene group-containing polymer composition, a surface treatment agent comprising the same and an article treated with the agent
An object of the present invention is to provide a fluorooxyalkylene group-containing polymer composition, which yields a coating having excellent adhesior to a substrate, good water- and oil-repellency, a low dynamic friction coefficient, good releasing property, good abrasion resistance and good stain resistance, and to provide a surface treatment agent comprising the same. The present inventors have found that a composition comprising a fluorooxyalkylene group-containing polymer having a fluorinated group and a hydrolyzable group at each terminal and a fluorooxyalkylene group-containing polymer having hydrolyzable groups at both terminals can form a coating which has excellent water- and oil-repellency, a low dynamic friction coefficient, good releasing property, good abrasion resistance, and good stain resistance.
US08420759B2 Polymers of isoprene from renewable resources
It has been found that certain cells in culture can convert more than about 0.002 percent of the carbon available in the cell culture medium into isoprene. These cells have a heterologous nucleic acid that (i) encodes an isoprene synthase polypeptide and (ii) is operably linked to a promoter. The isoprene produced in such a cultured medium can then be recovered and polymerized into synthetic rubbers and other useful polymeric materials. The synthetic isoprene containing polymers of this invention offer the benefit of being verifiable as to being derived from non-petrochemical based resources. They can also be analytically distinguished from rubbers that come from natural sources. The present invention more specifically discloses a polyisoprene polymer which is comprised of repeat units that are derived from isoprene monomer, wherein the polyisoprene polymer has δ13C value of greater than −22‰.
US08420756B2 Polymerisation of ethylene and alpha-olefins with catalyst systems based on binam derived ligands
The present invention relates to the field of single site catalyst systems based on aromatic BINAM diamine ligands and suitable for oligomerising or polymerising ethylene and alpha-olefins.
US08420751B2 Method for producing a polymer
Provided is a method for performing a polymerization process in a stirred reactor, wherein a critical time window is determined by means of a monitor of at least one polymerization process parameter and an associated process window, and when a critical time window is present, an adaptation of process conditions is made in order to configure the polymerization process to conform to the process window.
US08420748B2 Process for preparing branched Si-H functional polysiloxanes and use thereof for preparing liquid SiC- or SiOC-linked, branched modified organomodified polysiloxanes
The invention provides a process for preparing liquid, branched SiH-functional siloxanes by reacting a mixture of one or more low molecular weight SiH-functional siloxanes, one or more low molecular weight SiH-free siloxanes, one or more tetraalkoxysilanes, and optionally one or more trialkoxysilanes with addition of water and in the presence of a Brønsted-acidic ion exchanger, which is characterized in that the reaction is performed in one process step.
US08420747B2 Aliphatic polycarbonates for use in thermosetting powder coatings
A thermosetting polymer material capable of being used in powder coatings. The thermosetting polymer material includes at least one hydroxyl functional aliphatic polycarbonates that is formulated and crosslinked with isocyanates to yield a thermoset organic coating material. These materials provide improved weatherability as compared to prior art powder coating materials while also being less expensive than prior art materials utilizing fluorinated polymers.
US08420743B2 Propylene-based copolymer and film made of the same
A propylene-based copolymer is composed of 60 to 90% by weight of Component (A) that is a polymer component whose major structural unit is a structural unit derived from propylene and 10 to 40% by weight of Component (B) that is a propylene-ethylene copolymer component whose content of a structural unit derived from ethylene is 50 to 80% by weight, wherein the sum total of Component (A) and Component (B) is 100% by weight, wherein the ratio of the intrinsic viscosity of Component (B) ([η]B) to the intrinsic viscosity of Component (A) ([η]A)([η]B/[η]A) satisfies a formula: 1.3<[η]B/[η]A≦2.0, and the melt flow rate, measured at a temperature of 230° C. and a load of 21.18 N, of the copolymer is not less than 5 g/10 minutes and not more than 30 g/10 minutes.
US08420742B2 Interpolymers suitable for use in hot melt adhesives and processes to prepare the same
The present invention relates to an ethylene/α-olefin interpolymer product comprising at least one α-olefin interpolymerized with ethylene and, characterized in at least one aspect, as having improved properties when utilized in a hot melt adhesive formulation. The invention also relates to a process for manufacturing the interpolymer product wherein the process comprises employing two or more single site catalyst systems in at least one reaction environment (or reactor) and wherein the at least two catalyst systems have (a) different comonomer incorporation capabilities or reactivities and/or (b) different termination kinetics, both when measured under the same polymerization conditions. The interpolymer products are useful, for example, in applications such as hot melt adhesives, and also for impact, bitumen and asphalt modification, adhesives, dispersions or latexes and fabricated articles such as, but not limited to, foams, films, sheet, moldings, thermoforms, profiles and fibers.
US08420741B2 Ethylene based polymer composition and film
An ethylene based polymer composition comprising the following component (A) and the following component (B) wherein the content of the component (B) is 0.1 to 20 parts by weight per 100 parts by weight of the component (A):Component (A): an ethylene-α-olefin copolymer satisfying all of the following requirements (a1) to (a3): (a1) the density is 890 to 925 kg/m3, (a2) the melt flow rate (MFR) is 0.1 to 10 g/10 minutes, (a3) the flow activation energy (Ea) is less than 50 kJ/mol, Component (B): an ethylene-α-olefin copolymer satisfying all of the following requirements (b1) to (b3): (b1) the density is 890 to 925 kg/m3, (b2) the intrinsic viscosity [η] measured in a tetralin solution is 4 to 15 dL/g, (b3) the flow activation energy (Ea) is less than 50 kJ/mol.
US08420740B2 Method to repair a damaged intervertebral disc through the use of a bioadhesive, thermogelling hydrogel
The present invention is directed to a bioadhesive thermogelling hydrogel composition for repairing and/or augmenting an intervertebral disc. The bioadhesive thermogelling hydrogel composition can be cross linked with the surrounding tissue so as to potentially serve as a nucleus pulposus replacement or augmentation along with serving to repair annular tears or fissure. The bioadhesive thermogelling hydrogel composition may include three main components: a thermal responsive polymer, an amine-containing polymer and a crosslinking component. All three components can be modified and combined in numerous ways to serve the need of the system as long as the amine-containing component is kept separate from the crosslinking component until the components are injected. The incorporation of a two-part crosslinking thermal responsive hydrogel permits smaller amounts of the crosslinking component to be used and enables the crosslinking dialdehyde to be delivered locally into the tissue that will react with the hydrogel. This helps prevent damage to tissues away from the hydrogel.
US08420739B2 Fluorine-containing elastomer composition
There is provided a fluorine-containing elastomer composition assuring easy kneading and providing a crosslinked article having improved strength. The fluorine-containing elastomer composition comprises (A) an elastomer of a vinylidene fluoride/hexafluoropropylene copolymer having a branching coefficient of 30 to 300 ppm, a Mooney viscosity (ML1+10: 121° C.) of 7 to 80 and a molecular weight distribution (Mw/Mn) of 1.5 to 4, and (B) an elastomer of a vinylidene fluoride/hexafluoropropylene copolymer having a storage modulus G′ at 180° C. at 500 cpm of 500 to 900, and a mass ratio of (A)/(B) is 70/30 to 90/10.
US08420738B2 Thermoplastic elastomer composition and production process
A thermoplastic elastomer composition which has excellent cleanability and is suitable for use as a medical rubber supply. It is characterized by comprising a rubber ingredient dynamically crosslinked with a crosslinking agent and a matrix which comprises a thermoplastic resin and in which the crosslinked rubber ingredient has been dispersed, the crosslinking agent comprising a triazine derivative.
US08420730B2 Capsulated colorant, method of preparing the same, ink composition including the capsulated colorant
The present disclosure provides a capsulated colorant including a colorant and a polymer resin coating the colorant, wherein the polymer resin is obtained by polymerization of a polymerizable composition including a basic monomer, a macromonomer and a polymerizable unsaturated monomer; a method of preparing the capsulated colorant; and an ink composition including the capsulated colorant.
US08420728B2 Fiber-reinforced resin composition and molded body thereof
Long-fiber-reinforced thermoplastic resin particles and a blend thereof are provided, wherein the opening property of the reinforcing fibers during molding is good, and a molded body exhibiting an excellent appearance and having high mechanical strength is obtained. The particles (A) contain a thermoplastic resin (A1), produced by using a metallocene catalyst, a modified polyolefin resin (A2) modified with an unsaturated carboxylic acid or a derivative thereof, and reinforcing fibers (A3) and satisfying additional requirements described herein.
US08420727B2 Polycarbonate resin composition and preparation method thereof
A polycarbonate resin composition with excellent rigidity (flexural strength) and impact resistance, and a method of preparing the same are disclosed. The polycarbonate resin composition includes 1 to 70 parts by weight of a filament filler of 5˜30 mm based on 100 parts by weight of the total amount of a first polycarbonate resin (A) having a weight-average molecular weight of 25,000 g/mol or less, the filament filler (B), and one of a second polycarbonate resin (C) having a weight-average molecular weight of more than 25,000 g/mol and a rubber-modified styrene graft copolymer resin and a styrene copolymer resin (C′). The polycarbonate resin composition provides high rigidity and impact strength, and thus is useful to manufacture a variety of molded articles such as mobile products, electronic components, etc.
US08420725B2 Urethane resin composition, coating material, adhesive, cured product obtained using the same, and method for producing cured product
An object of the present invention is to provide a urethane resin composition that has excellent coating workability and storage stability not causing gelation with time and that can form a cured product such as a coating that has excellent heat resistance. The present invention relates to a urethane resin composition includes an alcohol-soluble urethane resin (A) having a hydrolyzable silyl group, inorganic particles (B), and an alcohol (C), in which the inorganic particles (B) have a functional group [Y] that can react with a functional group [X] generated from the hydrolyzable silyl group of the urethane resin (A), a coating material and an adhesive that contain the urethane resin composition, and a formed body obtained by using the urethane resin composition.
US08420723B2 Mix comprising trialkoxymercaptoalkyl-silanes
A method of producing a tire mix, including a first mixing step, in which a mix contains at least one cross-linkable unsaturated-chain polymer base, 10 to 100 phr of silica, and 1 to 20 phr of a silane bonding agent in the trialkoxymercaptoalkyl-silane class; and a final mixing step, in which a curing system is added to the mix. The silane bonding agent is used in adsorbed form on 0.5 to 2 phr of zinc oxide, and on 5 to 15 phr of carbon black. At the first mixing step, the mix contains 1 to 5 phr of one or more fatty acid derivatives, and, at the final mixing step, 1 to 2 phr of zinc oxide is added to the mix. The fatty acid derivatives are derived from condensation of a fatty acid, having a carbon number of 16 to 20, with an alcohol having a carbon number of 2 to 6, or with a primary or secondary amine having a carbon number of 2 to 6.
US08420722B2 Composition and methods of forming solder bump and flip chip using the same
Provided are a composition for an anisotropic conductive adhesive, a method of forming a solder bump and a method of forming a flip chip using the same. The composition for an anisotropic conductive adhesive includes a low melting point solder particle and a thermo-curable polymer resin. The anisotropic conductive adhesive includes forming a mixture by mixing a polymer resin and a curing agent, and mixing a deforming agent, a catalyst or a reductant with the mixture.
US08420721B2 Polyolefin resin composition
A polyolefin resin composition having a high crystallization temperature and excellent transparency is provided. The polyolefin resin composition comprises 0.01 to 10 parts by mass of a methylenebisanilide compound with respect to 100 parts by mass of a polyolefin resin, wherein the methylenebisanilide compound is represented by General Formula 1, wherein each of X1, X2, X3, X4, X5, X6, X7 and X8 independently represents a hydrogen atom or C1-C10 alkyl which is optionally substituted or branched; and each of R1 and R2 independently represents a hydrogen atom, C1-C21 alkyl which is optionally substituted or branched, C3-C12 cycloalkyl which is optionally substituted, or C6-C20 aryl which is optionally substituted.
US08420718B2 Composition, polymerizable composition, resin, optical component, and method for producing the composition
The composition of the present invention contains a product having a thiol group obtained by reacting an Sb or Bi oxide or an Sb or Bi halide with at least one kind of polythiol compounds selected from compounds having at least two thiol groups in a molecule.
US08420717B2 Polyol functionalized water soluble carbon nanostructures
A method of making a water soluble carbon nanostructure includes treating a fluorinated carbon nanostructure material with a polyol in the presence of a base. A water soluble carbon nanostructure comprises a fluorinated carbon nanostructure covalently bound to a polyol. Exemplary uses of water soluble carbon nanostructures include use in polymer composites, biosensors and drug delivery vehicles.
US08420713B2 Capsulated colorant, method of preparing the same, and ink composition including the capsulated colorant
Provided are a capsulated colorant, a method of preparing same and ink compositions including the capsulated colorant. The capsulated colorant includes a colorant and a polymer resin coated on the colorant. The polymer resin is a result of polymerization of a polymerizable composition comprising a basic monomer and a polymerizable unsaturated monomer. The ink composition comprises the colorant coated with the polymeric resin and a solvent, which may be water and at least one organic solvent.
US08420711B2 Mono ethylenically unsaturated polymerizable group containing polycarbosiloxane monomers
The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain monoethylenically unsaturated polymerizable group containing polycarbosiloxane monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices.
US08420708B2 Methods for making dental restorations using two-phase light-curing materials
Methods for making dental crowns, bridges, inlays, onlays, veneers, fillings, and other restorations are provided. The methods involve using a two-phase light curing (TPLC) material. Preferably, the TPLC material used to form the dental restoration comprises a blend of polymerizable compounds; photopolymerization systems (a) and (b), and particulate filler materials (a) and (b). In a first light-curing step, curing light having a wavelength of greater than 420 nm is used to activate system (a). In a second light-curing step, curing light having a wavelength of less than 420 nm is used to activate system (b). The two step light-curing method is efficient and allows the dentist to make restorations having high mechanical strength and pleasing aesthetics.
US08420707B2 Biomass composite composition and foaming method thereof
Disclosed herein are a biomass composite composition and a foaming method thereof. The biomass composite composition includes (a) polyester alloy containing biodegradable polyester and petrochemical plastic, (b) reinforcing agent, (c) foaming agent, (d) compatibilizer, (e) lubricant, and (f) impact modifier. The biomass composite composition of the present invention is biodegradable and of heat resistance and melt strength suitable for manufacture of foam products.
US08420705B2 Particulate materials for acoustic texture material
A composition for forming a textured coating on drywall material, where the textured coating substantially matches a pre-existing acoustic texture material on the drywall material, comprises acoustic texture material and propellant material. The acoustic texture material comprises a base portion the base portion is capable of existing in a flowable state and a hardened state, and a particulate portion the particulate portion comprises discrete, visible particles of solidified urethane foam having irregular shapes. The propellant material comprises a hydrocarbon propellant. The particles of urethane foam are distributed throughout the acoustic texture material when the base portion is in the flowable state. The irregular shapes of the particulate portion are substantially the same when the base portion is in the flowable state and in the hardened state. The base portion is capable of securing the discrete, visible, particles of solidified urethane foam to the drywall material when the base portion is in the hardened state.
US08420704B2 Nano-structured polymer composites and process for preparing same
A process for preparing a polymer composite that includes reacting (a) a multi-functional monomer and (b) a block copolymer comprising (i) a first block and (ii) a second block that includes a functional group capable of reacting with the multi-functional monomer, to form a crosslinked, nano-structured, bi-continuous composite. The composite includes a continuous matrix phase and a second continuous phase comprising the first block of the block copolymer.
US08420701B2 Polymer electrolyte membrane, membrane-electrode assembly for polymer electrolyte fuel cells and process for producing polymer electrolyte membrane
A polymer electrolyte membrane comprises at least one layer of a perforated sheet having many through-holes formed substantially parallel to the thickness direction with an average cross-sectional area per hole ranging from 1×10−3 to 20 mm2, wherein the numerical aperture based on the through-holes ranges from 30 to 80%, and the through-holes are filled with an ion exchange resin.
US08420698B2 Histone deacetylase inhibitors
Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy.
US08420697B2 Treatment of acute exacerbation of asthma and reduction of likelihood of hospitalization of patients suffering therefrom
The invention provides a method of improving one or more clinical outcomes of an individual experiencing an acute respiratory attack. The acute respiratory attack may include acute reversible bronchospasm, severe acute bronchospasm, or acute exacerbation of asthma. The method includes administering to an individual suffering from an acute respiratory attack an effective amount of bedoradrine or a pharmaceutically acceptable salt thereof in combination with a standard of care (SOC) treatment regimen.
US08420694B2 Pyrrolidin-2-one derivatives as androgen receptor modulator
A compound represented by the formula (I′): or a salt thereof, has a superior androgen modulating action, wherein R1, R2, R4 to R8, R10 and R11 are defined in the claim.
US08420690B2 Inhibitors of Akt activity
Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
US08420689B2 Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
The present invention relates to novel cannabinoid receptor modulators, in particular cannabinoid 1 (CB1) or cannabinoid 2 (CB2) receptor modulators, and uses thereof for treating diseases, conditions and/or disorders modulated by a cannabinoid receptor.
US08420683B2 5 substituted hydantoins
The present invention relates to 5-substituted hydantoins, a process for the preparation of 5-substituted hydantoins and the use of 5-substituted hydantoins in the preparation of enantiomerically enriched α-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel 5-substituted hydantoins.
US08420679B2 Aminothiazole derivatives and their use as CRF receptor ligands
Substituted 4-phenyl-2-aminothiazole derivatives, processes for preparing the same, and the use thereof as corticotrophin releasing factor (CRF) antagonists.
US08420678B2 Small molecule inhibitors of the pleckstrin homology domain and methods for using same
Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
US08420677B2 Use of 3,3′-diindolylmethane
Use of DIM and/or its derivatives for prevention, treatment and/or delay of age-related hearing loss in mammals.
US08420672B2 Solid forms of 3-(4-amino-1-oxo-1,3-dihydro-isoindo1-2-yl)-piperidine-2,6-dione and methods of making the same
The present invention provides for new crystalline and amorphous forms of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione, and methods of making the same.
US08420671B2 Stabilised thiophene derivatives
The present invention relates to a stabilized monomer composition comprising at least 50 wt.-%, based on the total weight of the stabilized monomer composition, of a thiophene derivative monomer having the general formula (I) in which R1 and R2 stand, independently of one another, for hydrogen, for an optionally substituted C1-C20-alkyl group or C1-C20-oxyalkyl group, optionally interrupted by 1 to 5 oxygen atoms and/or sulfur atoms, or jointly for an optionally substituted C1-C20-dioxyalkylene group or C6-C20-dioxyarylene group, and 0.001 to 10 wt.-%, based on the total weight of the stabilized monomer composition, of a stabilizer. The present invention also relates to a method for the manufacture of a capacitor, a capacitor obtained by this method, the use of a stabilized monomer composition and to the use of a stabilizer.
US08420669B2 Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the BETA2 adrenergic receptor
The present disclosure relates to 4-(2-amino-1-hydroxyethyl)phenol derivatives of formula (I) as well as pharmaceutical compositions comprising them, and their use in therapy as agonists of the BETA2 adrenergic receptor.
US08420666B2 Pyrazolo (3, 4-B) pyridine derivatives as phosphodiesterase inhibitors
The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed herein having the structure of Formula 1: can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4/PDE type 7 inhibitors are provided.
US08420664B2 A3 adenosine receptor allosteric modulators
The present invention relates to allosteric modulation of A3 adenosine receptor (A3AR) and provides for the use of an A3 adenosine receptor modulator (A3RM), for the preparation of pharmaceutical compositions for modulating the A3AR in a subject, as well as pharmaceutical compositions comprising the same and therapeutic methods comprising administering to a subject an amount of an A3RM, the amount being effective to modulate A3AR activity. The A3RM according to the invention are 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives. The invention also provides some of such novel 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives.
US08420663B2 Peripheral opioid receptor antagonists and uses thereof
The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
US08420660B2 Antitubercular alkaloid
A derivative of β-carboline alkaloid harmine, 10,12-diheptanoyl-11-hydroxy-3-methyl-β-carboline, prepared by a Friedel-Crafts acylation of harmine is reported as a novel potent antitubercular drug.
US08420655B2 Benzimidazole inhibitors of leukotriene production
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salt thereof, wherein R1-R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
US08420654B2 1,5-Diphenyl-pyrrolidin-2-one compounds as CB-1 ligands
CB-1 receptor inverse agonist compounds of Formula and pharmaceutical compositions for the treatment of obesity or cognitive impairment associated with schizophrenia.
US08420653B2 Pyrimidine compounds and their uses
Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases.
US08420651B2 Substituted 1-alkylcinnolin-4(1H)-one derivatives, preparation thereof and therapeutic application of same
The subject of the present invention is compounds corresponding to the formula (I) in which: X represents a divalent (C2-C5)alkylene radical which is unsubstituted or substituted one or more times by an Alk group; R1 represents a phenyl, a naphthyl, a pyridyl, a 1-benzothienyl or a 1,3-benzodioxolyl; R2 represents a hydrogen atom, a halogen atom, an Alk group, an OAlk group or else a group chosen from —S-Alk, —SO-Alk, —SO2-Alk, —CO—N(R4)-Alk, —N(R4)SO2-Alk, —N(R4)CO-Alk, —N(R4)SO2—N(Alk)2; R3 represents a hydrogen atom, a halogen atom, an Alk group or an OAlk group; R4 represents a hydrogen atom or a (C1-C4)alkyl; Alk represents an unsubstituted or substituted (C1-C4)alkyl. Preparation process and therapeutic application.
US08420650B2 Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP)
A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.
US08420648B2 Polymorphs of brimonidine pamoate
A brimonidine pamoate polymorph exhibits characteristics disclosed herein, wherein the brimonidine pamoate has the following formula The polymorph is included in a composition, device, or implant for use in the treatment or control of elevated intraocular pressure or in the neuroprotection of components of a neurological tissue to prevent progressive degeneration of such components. In particular, such a composition, device, or implant can be used to provide neuroprotection to cells and components of the optic nerve system.
US08420643B2 Compounds and method for treatment of cancer
The present invention is directed to methods of use of a compound of Formula I: and/or a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical isomer, or combination thereof, a composition comprising the thiosemicarbazone, a method of administration thereof, and use thereof to treat a cancer.
US08420639B2 Arylsulfonamide CCR3 antagonists
Provided herein are arylsulfonamides that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3-mediated disorder, disease, or condition.
US08420633B2 Aryl-cyclohexyl-tetraazabenzo[e]azulenes
The present invention is concerned with aryl-cyclohexyl-tetraazabenzo[e]azulenes of formula I wherein R1, R2 and R3 are as described herein. The invention further provides methods for the manufacture of such compounds and pharmaceutical compositions containing them. The compounds according to the invention act as V1a receptor modulators, and in particular as V1a receptor antagonists. The compounds are useful as therapeutics acting peripherally and centrally in the conditions of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior.
US08420630B2 Pyrimidine derivatives
The present invention relates to trisubstituted pyrimidines of formula (I) wherein 0Ra to Re are defined as in claim 1, which are suitable for the treatment of illnesses characterized by excessive or abnormal cell proliferation, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.
US08420629B2 Azetidine and cyclobutane derivatives as JAK inhibitors
The present invention relates to azetidine and cyclobutane derivatives, as well as their compositions, methods of use, and processes for preparation, which are JAK inhibitors useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
US08420626B2 Arene connected polyamine macrocyclic derivatives, preparation methods and pharmaceutical uses thereof
The present invention relates to arene connected polyamine macrocyclic derivatives represented by general formula I, pharmaceutically acceptable salts or hydrates thereof which have anti-HIV activities, in which the definitions of substituents are as defined in the description; to preparation methods of the compounds of formula I; to pharmaceutical compositions containing the compounds of formula I or their pharmaceutically acceptable salts or hydrates; to the use of the compounds of formula I or their pharmaceutically acceptable salts or hydrates for the preparation of a medicament for the treatment and prevention of HIV-associated diseases.
US08420625B2 Lipolytic methods for regional adiposity
Compositions, formulations, methods, and systems for treating regional fat deposits comprise contacting a targeted fat deposit with a composition comprising long acting beta-2 adrenergic receptor agonist and a compound that reduces desensitization of the target tissue to the long acting beta-2 adrenergic receptor agonist, for example, glucocorticosteroids and/or ketotifen. Embodiments of the composition are administered, for example, by injection, and/or transdermally.
US08420624B2 Methods for treating or preventing symptoms of hormonal variations
The present invention relates to methods for treating or preventing symptoms of hormonal variation. The method comprises the steps of administering an effective amount of a receptor antagonist to a subject having one or more symptoms of hormonal variations, wherein the receptor antagonist binds to at least one receptor selected from the group consisting of a serotonin type 2A (5-HT2A) and a dopamine type 2 (D2) receptors.
US08420621B2 Methods of using gamma cyclodextrin to control blood glucose and insulin secretion
Disclosed are methods of producing a blunted postprandial glycemic response in an individual, and/or reducing postprandial insulin secretion, said methods comprising administering to the individual a nutritional or other product comprising gamma-cyclodextrin. Also disclosed are similar other methods directed toward the use of such products to provide weight and appetite control, to normalize blood glucose levels in individuals with impaired glucose tolerance, to minimize nighttime hypoglycemia in diabetic and non-diabetic patients, to prevent reactive hypoglycemia in susceptible non-diabetics, to normalize blood glucose levels in individuals with gestational diabetes or impaired glucose tolerance during gestation, and/or to provide a prolonged glycemic response during exercise. The methods are based upon the discovery that gamma-cyclodextrins are rapidly metabolized and absorbed in the small intestine, but subsequently result in a surprisingly blunted postprandial glycemic response and reduced insulin secretion.
US08420620B2 Induced internalization of surface receptors
Disclosed is a hetero-bifunctional ligand for use in inducing internalization of a target receptor. The hetero-bifunctional ligand includes a target receptor-binding agent that specifically binds the target receptor linked to an internalizing receptor-binding agent that specifically binds to an internalizing receptor, where the two binding agents are non-identical. Also disclosed is a method of inducing the internalization of a target receptor on a cell. The method includes contacting a cell with a hetero-bifunctional ligand, where binding of the hetero-bifunctional ligand induces internalization of a target receptor of the cell. Also disclosed a method of treating a disease or condition associated with a target receptor using the disclosed hetero-bifunctional ligand and pharmaceutical compositions including a hetero-bifunctional ligand.
US08420617B2 Multiantivirus compound, composition and method for treatment of virus diseases
A method for obtaining a new antiviral compound with multiple action against many viruses, comprising modified highly purified yeast RNA, a pharmaceutical composition comprising such RNA, and a method for the treatment and prevention of viral disease comprising administering to a patient a composition comprising an amount effective to ameliorate the symptoms of viral disease of ribonucleic acid. The exogenous modified yeast RNA has a pronounced multiple anti-virus action in a wide range of concentrations. The modified yeast RNA is capable of inhibiting the reproduction of viruses from Orthomyxoviridae, Paramyxovirus, Hepatitis, Herpesviridae families, enterovirus and adenovirus. Also, the modified yeast RNA is capable of inhibiting the reproduction of influenza viruses, hepatitis C virus, genital herpes, human immunodeficiency virus and Coxsackie B virus.
US08420611B2 Combined gene therapy for the treatment of macroscopic gliomas
Described herein are compositions and methods for the treatment of cancer, and particularly brain cancer (e.g., glioma) in a mammal. In various embodiments of the invention, a combined therapeutic approach including TK with systemic ganciclovir administration and Flt3L are used in connection with gene therapeutic techniques or direct peptide injection for the aforementioned indications. Kits useful in practicing the inventive method are also disclosed, as are animal models useful for studying brain cancer.
US08420606B2 Method of utilizing physiological activity of rare saccharide and composition containing rare saccharide
A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.
US08420602B2 Endocannabinoid conjugate and a pharmaceutical composition for treatment of neuronal disorders
A compound provided by the present invention includes an endocannabinoid, endocannabinoid derivative, or endocannabinoid analog moiety covalently bonded to a biologically active peptide. One example of an inventive compound described is a conjugate of an endocannabinoid, endocannabinoid derivative, or endocannabinoid analog moiety covalently coupled to an opioid peptide, such as an endorphin, enkephalin, dynorphin or endomorphin. Also detailed are processes for making the described conjugates and pharmaceutical compositions including such compounds.
US08420600B2 Injectable capsaicin
The present invention is directed to compositions and methods for relieving pain at a site in a human or animal by administering at a discrete site in a human or animal a dose of capsaicin in an amount effective to denervate the discrete site without eliciting an effect outside the discrete location.
US08420599B2 Bone-reinforcing food material
Disclosed is a bone-reinforcing agent which comprises a milk protein fraction having the following properties (1) to (4): (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein component having a molecular weight of 6,000 to 150,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 12 to 14 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.5 to 0.7; and (4) the milk protein fraction has an activity of accelerating the calcification in an osteoblast.
US08420598B2 Mono modified exendin with polyethylene glycol or its derivatives and uses thereof
Disclosed herein are exendin singly modified with polyethylene glycole or a derivative thereof, a method for the preparation of the same, and uses thereof. Exendin modified at lysine (27) with polyethylene glycol shows biological activity similar to that of natural exendin, but is improved in half life. In addition, the modification position and the number of PEG or its derivative are restricted so as to minimize the side effects caused by a variety of combinations of such factors. The exendin is useful in the prevention and treatment of diseases caused by the over-secretion of insulin, or diseases caused due to a decrease in plasma glucose level, the inhibition of gastric or intestinal motility, the promotion of satiety, or the inhibition of food intake, especially diabetes, obesity and irritable colon syndrome.
US08420595B2 Methods for treating acute acoustic trauma
The current invention provides methods and compositions for treating sensorineural hearing loss including but not limited to acute acoustic trauma (AAT). The composition includes compounds which function as free radical traps such as phenyl butyl nitrone (PBN), free radical scavengers, such as edaravone, resveratrol, ebselen and iron chelator and compounds from the family of antioxidant compounds including, but not limited to, N-acetylcysteine (NAC), Acetyl-L-Carnitine (ALCAR), glutathione monoethylester, ebselen, D-methionine and carbamathione. The compositions of the current invention may be delivered by injections or orally.
US08420594B2 Inhibitors of MRP4 and agents stimulating MRP4 activity for the treatment of cardiac disorders
The invention relates to inhibitors of Multi drug Resistant Protein 4 (MRP4) for the treatment and/or the prevention of cardiac disorders, such as acute or chronic heart failure and cardiogenic shock. The invention also relates to agents stimulating MRP4 activity for the treatment and/or the prevention of cardiac hypertrophy.
US08420593B1 Compositions and methods for regulating membrane potential
Compositions are described according to embodiments of the present invention which include a neuronal potassium channel antagonist and a neuronal sodium channel antagonist, the neuronal potassium channel antagonist and the neuronal sodium channel antagonist each conjugated to a transporter moiety to form one or more conjugates. The transporter moiety is capable of crossing the blood/brain or blood/nerve barrier such that the conjugate is delivered to the brain and/or nerve. Inventive methods of treating a demyelinating condition in a subject are described herein which include administering an effective amount of a conjugate composition of the present invention to a subject having a demyelinating condition.
US08420590B2 Genes and proteins that home to developing microvessels
Described herein are polypeptides that home to developing microvasculature, (also referred to as developing microvessels), such as newly developing microvasculature in mammals, particularly in humans, and to DNA that encodes such polypeptides. These polypeptides are referred to herein as developing microvasculature homing polypeptides. In a specific embodiment, the homing peptides are collateral vessel endothelia (CVE) homing polypeptides, which have been shown to home to collateral vessel endothelia after ischemia.
US08420586B2 Thickened oven cleaner comprising a glutamic acid salt or disodium ethanol diglycine chelant
Cleaner compositions, associated cleaners, and associated methods are disclosed. The cleaner compositions are capable for use in making thickened cleaners that are capable of removing from vertical and inverted surfaces fresh, greasy soils and baked-on soils encountered in the food service industry. The cleaner compositions include one or more alkalinity sources, one or more chelants, one or more surfactants, one or more thickening agents, one or more buffers, and as a remainder, water. Cleaner compositions of the invention are substantially free of phosphates and have a low caustic content making them user and environmentally friendly. Yet the cleaners of the invention are surprisingly effective at removing tenacious baked-on soils encountered in the food service industry. Compositions of the invention have a viscosity of about 700 cps and are applied using a foaming or misting dispenser. The one or more alkalinity sources may be present in an amount sufficient to provide a free alkalinity (expressible as Na2O) of less than about 1.0 wt % and a total alkalinity (expressible as Na2O) of less than about 2.0 wt %, based on the total weight of the cleaner concentrate. The one or more chelants may be present in an amount up to about 5.0 wt %.
US08420582B2 Friction and wear modifiers using solvent partitioning of hydrophilic surface-interactive chemicals contained in boundary layer-targeted emulsions
A wear and/or friction reducing additive for a lubricating fluid in which the additive is a combination of a moderately hydrophilic single-phase compound and an anti-wear and/or anti-friction aqueous salt solution. The aqueous salt solution produces a coating on boundary layer surfaces. The lubricating fluid can be an emulsion-free hydrophobic oil, hydraulic fluid, antifreeze, or water. Preferably, the moderately hydrophilic single-phase compound is sulfonated castor oil and the aqueous salt solution additionally contains boric acid and zinc oxide. The emulsions produced by the aqueous salt solutions, the moderately hydrophilic single-phase compounds, or the combination thereof provide targeted boundary layer organizers that significantly enhance the anti-wear and/or anti-friction properties of the base lubricant by decreasing wear and/or friction of sliding and/or rolling surfaces at boundary layers.
US08420576B2 Hydrophobically and cationically modified relative permeability modifiers and associated methods
Methods comprising introducing a hydrophobically and cationically modified relative permeability modifier into a portion of a subterranean formation. The hydrophobically and cationically modified relative permeability modifier comprises a hydrophilic polymer backbone with a hydrophobic modification and a cationic modification. The cationic modification may comprise at least one cationic compound comprising an alkyl chain length of from 1 to 3 carbons.
US08420570B2 Chiral 3-(benzylsulfinyl)-5,5-dimethyl-4,5-dihydroisoxazole derivatives and 5,5-dimethyl-3-[(1H-pyrazol-4-ylmethyl)sulfinyl]-4,5-dihydroisoxazole derivatives, method for the production thereof, and use of same as herbicides and plant growth regulations
The invention relates to 3-(benzylsulfinyl)-5,5-dimethyl-4,5-dihydroisoxazole derivatives and 5,5-dimethyl-3-[(1H-pyrazol-4-ylmethyl)sulfinyl]-4,5-dihydroisoxazole derivatives of the formula (I) and their salts processes for their preparation and their use as herbicides and plant growth regulators, in particular as herbicides for the selective control of harmful plants in crops of useful plants.
US08420568B2 Color-developing compositions and recording material containing same
Provided is a color-developing composition for recording materials having a superior heat resistance. The color-developing composition is a reaction composition containing a mixture of compounds represented by formula (III) obtained by reacting a dihydroxydiphenylsulfone derivative represented by formula (I) with a dihalide represented by formula (II) X—Y—X (II), wherein, in a composition where the content of a compound with n=1 in said reaction composition is from 5 to 80% by mass of the total solid content of the composition, at least 10% by mass of the compound with n=1 is a crystalline material.
US08420567B1 Process for superabsorbent polymer and crosslinker composition
The present invention further relates to a process to make a superabsorbent polymer comprising the steps of a) preparing a neutralized monomer solution comprising a polymerizable monomer selected from unsaturated acid groups-containing monomers, ethylenically unsaturated carboxylic acid anhydride, salts, or derivatives thereof and a caustic agent selection from an alkali agent, wherein the polymerizable monomer is neutralized to from about 50 mol % to about 85 mol %; b) forming a crosslinker monomer mixture by adding an internal crosslinker composition to the neutralized monomer solution wherein the internal crosslinking composition is the reaction product of a stoichiometric excess of amine with a glycidyl compound, wherein the internal crosslinker composition has a residual amount of glycidyl compounds of less than about 500 ppm based on the mass of the internal crosslinker composition; and c) polymerizing the crosslinker monomer mixture to make a superabsorbent polymer.
US08420566B2 High efficiency ammoxidation process and mixed metal oxide catalysts
A process and novel catalyst for the production of acrylonitrile, acetonitrile and hydrogen cyanide characterized by the relative yields of acrylonitrile, acetonitrile and hydrogen cyanide produced in the process and by the catalyst, which are defined by the following: α=[(% AN+(3×% HCN)+(1.5×% ACN))÷% PC]×100 wherein % AN is the Acrylonitrile Yield and % AN≧81, % HCN is the Hydrogen Cyanide Yield, % ACN is the Acetonitrile Yield, % PC is the Propylene Conversion, and α is greater than 100.
US08420564B2 Sulfur-tolerant catalyst prepared through high pressure decomposition
A method of producing a MoS2 catalyst. The method begins by the decomposition of ammonium tetrathiomolybdate in an organic solvent. This decomposition is done in the presence of a solution comprising: a solvent and a promoter, and done under gaseous pressure.
US08420560B2 Dielectric ceramic, method for producing dielectric ceramic, and method for producing powder for producing dielectric ceramic
A dielectric ceramic includes a main component and a minor component. The main component includes a BaTi4O9 crystal phase and a Ba2Ti9O20 crystal phase, is represented by BaO.xTiO2, has a molar ratio x of TiO2 to BaO of 4.6 to 8.0, and in X-ray diffraction, and has an X-ray diffraction peak intensity ratio I29/I14 of a maximum diffraction peak intensity (I14) of the BaTi4O9 crystal phase to a maximum diffraction peak intensity (I29) of the Ba2Ti9O20 crystal phase of 1 or more. The minor component includes a boron oxide and a copper oxide, in which the boron oxide content is in the range of 0.5 to 5.0 parts by mass with respect to 100 parts by mass of the main component, and the copper oxide content is in the range of 0.1 to 3.0 parts by mass with respect to 100 parts by mass of the main component.
US08420559B2 Multilayer ceramic capacitor
Disclosed is a multilayer ceramic capacitor which is formed by alternately laminating (i) dielectric layers composed of a dielectric ceramic and (ii) internal electrode layers. The dielectric ceramic is composed of crystal grains mainly composed of barium titanate, while containing predetermined amounts of magnesium, vanadium, manganese and terbium, and at least one rare earth element selected from yttrium, dysprosium, holmium and erbium. In an x-ray diffraction chart of the dielectric ceramic, the diffraction intensity of the (200) plane indicating cubic barium titanate is higher than the diffraction intensity of the (002) plane indicating tetragonal barium titanate. The dielectric ceramic has a Curie temperature of 110-120° C.
US08420555B2 Manufacturing method for semiconductor device and manufacturing apparatus for semiconductor device
A manufacturing method for a semiconductor device including: determining pattern dependency of a radiation factor of an element forming surface of one wafer having a predetermined pattern formed on the wafer; determining a heating surface of the wafer, based on the pattern dependency of the radiation factor; holding the one wafer having the determined heating surface and another wafer having a determined heating surface, spaced at a predetermined distance in such a manner that non-heating surfaces of the one wafer and the another wafer oppose to each other; and heating the each heating surface of the one wafer and the another wafer.
US08420550B2 Method for cleaning backside etch during manufacture of integrated circuits
A method for manufacturing semiconductor substrates. The method includes providing a semiconductor wafer, which has an upper surface, a backside surface, and an edge region around a periphery of the semiconductor wafer. In a preferred embodiment, the upper surface is often for the manufacture of the integrated circuit device elements themselves. The method includes subjecting the semiconductor wafer to one or more process steps to form one or more films of materials on the backside surface. The method mounts the semiconductor wafer to expose the backside surface. The method rotates the semiconductor wafer in a circular manner. In a specific embodiment, the method includes supplying an acid solution containing fluorine bearing species, a nitric acid species, a surfactant species, and an organic acid species, on at least the backside surface as the semiconductor wafer rotates. The method causes removal of one or more contaminants from the backside surface, while a portion of the center region of the backside surface remains exposed as the semiconductor wafer rotates in the circular manner.
US08420549B2 Etching and cleaning methods and etching and cleaning apparatuses used therefor
A method of manufacturing a semiconductor device includes preparing a semiconductor wafer having a device area, an end face, and a surface peripheral area located outside the device area and between the end face and the device area. Forming a Cu layer on the semiconductor wafer and rotating the wafer in a horizontal plane. Emitting a first liquid from an edge nozzle towards the surface peripheral area which selectively removes a first unnecessary material in the surface peripheral area. Emitting a protecting liquid toward the semiconductor wafer, thereby protecting the device area from the first liquid. An angle of a longitudinal axis of the edge nozzle with respect to a tangent of the semiconductor wafer at a point, where the longitudinal axis of the edge nozzle intersects the end face of the wafer, is set in the range of 0 to 90 degrees in plan view.
US08420548B2 Method for treating germanium surfaces and solutions to be employed therein
The present invention concerns an improved method for treating germanium surfaces in order to reveal crystal defects.
US08420547B2 Plasma processing method
A plasma processing method performed in a plasma processing apparatus including a processing chamber accommodating a substrate in which a plasma is generated; a mounting table mounting the substrate, which is provided in the processing chamber and to which a plasma attraction high frequency voltage is applied; and a facing electrode provided to face the mounting table in the processing chamber, to which a negative DC voltage is applied, the method including: applying a plasma attraction high frequency voltage to the mounting table for a predetermined period of time; and stopping the application of the plasma attraction high frequency voltage to the mounting table. In the plasma processing method, the application of the plasma attraction high frequency voltage and stopping thereof are alternately repeated.
US08420544B2 Method for fabricating interconnection structure with dry-cleaning process
A method for fabricating an interconnection structure includes the following steps. Firstly, a substrate having a first conductive layer thereon is provided. Next, an ultra low-k material layer is formed on the substrate. Next, a portion of the ultra low-k material layer is removed, so as to form an opening to expose the first conductive layer. Next, a dry-cleaning process is performed by using gas, so as to clean a surface of the first conductive layer exposed by the opening. The dry-cleaning process is performed at a temperature in a range from the room temperature to 100° C.
US08420542B2 Method of patterned image reversal
A method of forming a reverse image pattern on a semiconductor base layer is disclosed. The method comprises depositing a transfer layer of amorphous carbon on the semiconductor base layer, depositing a resist layer on the transfer layer, creating a first pattern in the resist layer, creating the first pattern in the transfer layer, removing the resist layer, depositing a reverse mask layer, planarizing the reverse mask layer, and removing the transfer layer, thus forming a second pattern that is a reverse image of the first pattern.
US08420532B2 Method of manufacturing semiconductor device
The present invention relates to a method of fabricating a semiconductor device. According to the method, a first insulating layer having a contact hole formed therein is formed over a semiconductor substrate. A second insulating layer is gap filled within the contact hole. A third insulating layer having a trench formed therein is formed over the semiconductor substrate including the contact hole. The second insulating layer gap filled within the contact hole is removed. A contact plug and a bit line are formed within the contact hole and the trench.
US08420529B2 Copper wiring surface protective liquid and method for manufacturing semiconductor circuit
A copper wiring material surface protective liquid for production of a semiconductor device is provided, containing an oxyalkylene adduct of an acetylenediol containing an acetylenediol having an oxyalkylene having 2 or 3 carbon atoms added thereto. A method for producing a semiconductor circuit device is provided, containing: forming an insulating film and/or a diffusion preventing film on a silicon substrate; then forming a copper film by a sputtering method; then forming a copper wiring containing 80% by mass or more of copper thereon by a plating method; and flattening the wiring by a chemical mechanical polishing (CMP) method, thereby providing a semiconductor substrate containing a copper wiring, the semiconductor substrate having an exposed surface of a copper wiring material being treated by making in contact with the copper wiring material surface protective liquid.
US08420519B1 Methods for fabricating integrated circuits with controlled P-channel threshold voltage
Methods are provided for fabricating integrated circuits having controlled threshold voltages. In accordance with one embodiment a method includes forming a gate dielectric overlying an N-doped silicon substrate and depositing a layer of titanium nitride and a layer of tantalum nitride overlying the gate dielectric. A sub-monolayer of tantalum oxide is deposited overlying the layer of tantalum nitride by a process of atomic layer deposition, and oxygen is diffused from the tantalum oxide through the tantalum nitride and titanium nitride.
US08420518B2 Structure and method of latchup robustness with placement of through wafer via within CMOS circuitry
A method of manufacturing a semiconductor structure includes: forming a trench in a back side of a substrate; depositing a dopant on surfaces of the trench; forming a shallow trench isolation (STI) structure in a top side of the substrate opposite the trench; forming a deep well in the substrate; out-diffusing the dopant into the deep well and the substrate; forming an N-well and a P-well in the substrate; and filling the trench with a conductive material.
US08420515B2 Method of producing a solar cell
A method for manufacturing a solar cell is disclosed. A conductive layer is introduced into a mold having an interior defining a shape of a solar cell. A planar capillary space is formed along the conductive layer. A measure of silicon is placed in fluid communication with the capillary space. The silicon is melted and allowed to flow into the capillary space. The melted silicon is then cooled within the capillary space such that the silicon forms a p-n junction along the conductive layer.
US08420513B2 Method of fabricating thin film transistor
A thin film transistor (TFT), including a crystalline semiconductor pattern on a substrate, a gate insulating layer on the crystalline semiconductor pattern, the gate insulating layer having two first source/drain contact holes and a semiconductor pattern access hole therein, a gate electrode on the gate insulating layer, the gate electrode being between the two first source/drain contact holes, an interlayer insulating layer covering the gate electrode, the interlayer insulating layer having two second source/drain contact holes therein, and source and drain electrodes on the interlayer insulating layer, each of the source and drain electrodes being insulated from the gate electrode, and having a portion connected to the crystalline semiconductor pattern through the first and second source/drain contact holes.
US08420508B2 Integrated circuit packaging system with bump contact on package leads and method of manufacture thereof
A method of manufacture of an integrated circuit packaging system includes: providing a base panel having a first side with a cavity and a second side opposite the first side; connecting an integrated circuit device and the first side; applying a resist mask having an opening on the second side, the opening offset from the cavity; forming a bump contact in the opening; applying an encapsulation in the cavity over the integrated circuit device and the first side; and forming a package lead by removing a portion of the base panel under the cavity, a flared tip of the package lead intersecting a base side of the encapsulation.
US08420507B2 Laser processing method
A modified region 7 to become a starting point region for cutting is formed in a GaAs substrate 12 along a line to cut 5 upon radiation with laser light L which is pulsed laser light. As a consequence, the modified region 7 formed in the GaAs substrate 12 along the line to cut 5 is likely to generate fractures in the thickness direction of an object to be processed 1. Therefore, the modified region 7 having an extremely high function as a starting point region for cutting can be formed in the planar object to be processed 1 comprising the GaAs substrate 12.
US08420504B2 Method for manufacturing semiconductor device
There are provided a semiconductor device having a structure which can realize not only suppression of a punch-through current but also reuse of a silicon wafer used for bonding, in manufacturing a semiconductor device using an SOI technique, and a manufacturing method thereof. A semiconductor film into which an impurity imparting a conductivity type opposite to that of a source region and a drain region is implanted is formed over a substrate, and a single crystal semiconductor film is bonded to the semiconductor film by an SOI technique to form a stacked semiconductor film. A channel formation region is formed using the stacked semiconductor film, thereby suppressing a punch-through current in a semiconductor device.
US08420502B2 Group III-V semiconductor device and method for producing the same
A method for producing a Group III-V semiconductor device, includes forming, on a base, a plurality of semiconductor devices isolated from one another, forming, through ion implantation, a high-resistance region in a surface layer of a side surface of each semiconductor device, after formation of the high-resistance region, forming a p-electrode and a low-melting-point metal diffusion prevention layer on the top surface of the semiconductor device, bonding the semiconductor device to a conductive support substrate via a low-melting-point metal layer, and removing the base through the laser lift-off process.
US08420501B2 Transfer method of functional region, LED array, LED printer head, and LED printer
A method includes arranging a first bonding layer on a first functional region on a first substrate, or a region on a second substrate, bonding the first functional region to the second substrate through the first bonding layer, subjecting a first release layer to a first process to separate the first substrate from the first functional region at the first release layer, arranging a second bonding layer on a second functional region on the first substrate, or a region on a third substrate, bonding the second functional region to the second or third substrate through the second bonding layer, and subjecting a second release layer to a second process to separate the first substrate from the second functional region at the second release layer.
US08420495B2 Manufacturing approach for collector and a buried layer of bipolar transistor
This invention disclosed a manufacturing approach of collector and buried layer of a bipolar transistor. One aspect of the invention is that a pseudo buried layer, i.e, collector buried layer, is manufactured by ion implantation and thermal anneal. This pseudo buried layer has a small area, which makes deep trench isolation to divide pseudo buried layer unnecessary in subsequent process. Another aspect is, the doped area, i.e, collector, is formed by ion implantation instead of high cost epitaxy process. This invention simplified the manufacturing process, as a consequence, saved manufacturing cost.
US08420491B2 Structure and method for replacement metal gate field effect transistors
A structure and method for replacement metal gate (RMG) field effect transistors is disclosed. Silicide regions are formed on a raised source-drain (RSD) structure. The silicide regions form a chemical mechanical polish (CMP) stopping layer during a CMP process used to expose the gates prior to replacement. Protective layers are then applied and etched in the formation of metal contacts.
US08420480B2 Patterning a gate stack of a non-volatile memory (NVM) with formation of a gate edge diode
A gate-edge diode is made in a diode region of a substrate and a non-volatile memory cell is made in an NVM region of the substrate. A first dielectric layer is formed on the substrate in the diode region and the NVM region. A first conductive layer is formed on the first dielectric layer. A second dielectric layer is formed on the first conductive layer. A second conductive layer is formed over the second dielectric layer. A first mask is formed over the diode region having a first pattern. The first pattern is of a plurality of fingers and a second mask over the NVM region has a second pattern. The second pattern is of a gate stack of the non-volatile memory cell. An etch is performed through the second conductive layer, the second dielectric layer, and the first conductive layer to leave the first pattern of the plurality of fingers in the diode region and the second pattern of the gate stack in the NVM region. An implant is performed using the gate stack and the plurality of fingers as a mask to provide source/drain regions adjacent to the gate stack in the NVM region and diode terminals between the fingers in the diode region to form the gate-edge diode with the diode terminals and the substrate.
US08420479B2 Semiconductor device comprising a capacitor formed in the contact level
A contact level in a semiconductor device may be used for providing a capacitor that may be directly connected to a transistor, thereby providing a very space-efficient capacitor/transistor configuration. For example, superior dynamic RAM arrays may be formed on the basis of the capacitor/transistor configuration disclosed herein.
US08420476B2 Integrated circuit with finFETs and MIM fin capacitor
An integrated circuit having finFETs and a metal-insulator-metal (MIM) fin capacitor and methods of manufacture are disclosed. A method includes forming a first finFET comprising a first dielectric and a first conductor; forming a second finFET comprising a second dielectric and a second conductor; and forming a fin capacitor comprising the first conductor, the second dielectric, and the second conductor.
US08420474B1 Controlling threshold voltage in carbon based field effect transistors
A field effect transistor fabrication method includes defining a gate structure on a substrate, depositing a dielectric layer on the gate structure, depositing a first metal layer on the dielectric layer, removing a portion of the first metal layer, depositing a second metal layer, annealing the first and second metal layers, and defining a carbon based device on the dielectric layer and the gate structure.
US08420471B2 Dense pitch bulk FinFET process by selective EPI and etch
Disclosed is a method of forming a pair of transistors by epitaxially growing a pair of silicon fins on a silicon germanium fin on a bulk wafer. In one embodiment a gate conductor between the fins is isolated from a conductor layer on the bulk wafer so a front gate may be formed. In another embodiment a gate conductor between the fins contacts a conductor layer on the bulk wafer so a back gate may be formed. In yet another embodiment both of the previous structures are simultaneously formed on the same bulk wafer. The method allow the pairs of transistors to be formed with a variety of features.
US08420470B2 Method of fabricating a semiconductor device using compressive material with a replacement gate technique
The disclosed method of fabricating a semiconductor device structure forms a dummy gate structure on a substrate, deposits a dielectric material overlying the dummy gate structure in a manner that forms angled sidewalls of the deposited dielectric material outboard the spacers, and conformally deposits a compressive material overlying the deposited dielectric material such that the deposited compressive material forms angled peaks overlying the dummy gate structure. The method continues by forming an upper dielectric layer overlying the deposited compressive material, planarizing the resulting device structure, and exposing the temporary gate element of the dummy gate structure. Thereafter, the temporary gate element is removed, while leaving sections of the deposited compressive material outboard the spacers, and the gate recess is filled with a gate electrode material. The compressive material pulls the upper ends of the spacers apart to facilitate filling the gate recess.
US08420469B2 Schottky FET fabricated with gate last process
A method for forming a field effect transistor (FET) includes forming a dummy gate on a top semiconductor layer of a semiconductor on insulator substrate; forming source and drain regions in the top semiconductor layer, wherein the source and drain regions are located in the top semiconductor layer on either side of the dummy gate; forming a supporting material over the source and drain regions adjacent to the dummy gate; removing the dummy gate to form a gate opening, wherein a channel region of the top semiconductor layer is exposed through the gate opening; thinning the channel region of the top semiconductor layer through the gate opening; and forming gate spacers and a gate in the gate opening over the thinned channel region.
US08420467B2 Semiconductor device and method for manufacturing the same
A semiconductor device has a semiconductor substrate, a semiconductor fin which is formed on the semiconductor substrate, which has a long side direction and a short side direction, and which has a carbon-containing silicon film including an impurity and a silicon film formed on the carbon-containing silicon film, a gate electrode which is formed to face both side surfaces of the semiconductor fin in the short side direction, source and drain regions which are respectively formed in the semiconductor fin located in the direction of both sides in the long side direction of the semiconductor fin so as to sandwich the gate electrode, and an element isolation insulating film which is formed on the side surface of the semiconductor fin and between the gate electrode and the semiconductor substrate.
US08420466B2 Method of forming TFT floating gate memory cell structures
A device having thin-film transistor (TFT) floating gate memory cell structures is provided. The device includes a substrate, a dielectric layer on the substrate, and one or more source or drain regions being embedded in the dielectric layer. the dielectric layer being associated with a first surface. Each of the one or more source or drain regions includes an N+ polysilicon layer on a diffusion barrier layer which is on a first conductive layer. The N+ polysilicon layer has a second surface substantially co-planar with the first surface. Additionally, the device includes a P− polysilicon layer overlying the co-planar surface and a floating gate on the P− polysilicon layer. The floating gate is a low-pressure CVD-deposited silicon layer sandwiched by a bottom oxide tunnel layer and an upper oxide block layer. Moreover, the device includes at least one control gate made of a P+ polysilicon layer overlying the upper oxide block layer. A method of making the same memory cell structure is provided and can be repeated to integrate the structure three-dimensionally.
US08420463B2 Method for manufacturing pixel structure
A pixel structure includes a scan line, a data line, an active element, a first passivation layer, a second passivation layer and a pixel electrode. The data line includes a first data metal segment and a second data metal layer. The active element includes a gate electrode, an insulating layer, a channel layer, a source and a drain. The channel layer is positioned on the insulating layer above the gate electrode. The source and the drain are positioned on the channel layer. The source is coupled to the data line. The first passivation layer and the second passivation layer cover the active element and form a first contact hole to expose a part of the drain. The second passivation layer covers a part edge of the drain. The pixel electrode is disposed across the second passivation layer and coupled to the drain via the first contact hole.
US08420460B2 Method, structure and design structure for customizing history effects of SOI circuits
A design structure is embodied in a machine readable medium for designing, manufacturing, or testing a design. The design structure includes a high-leakage dielectric formed over an active region of a FET and a low-leakage dielectric formed on the active region and adjacent the high-leakage dielectric. The low-leakage dielectric has a lower leakage than the high-leakage dielectric. Also provided is a structure and method of fabricating the structure.
US08420459B1 Bulk fin-field effect transistors with well defined isolation
A fin field-effect-transistor fabricated by forming a dummy fin structure on a semiconductor substrate. A dielectric layer is formed on the semiconductor substrate. The dielectric layer surrounds the dummy fin structure. The dummy fin structure is removed to form a cavity within the dielectric layer. The cavity exposes a portion of the semiconductor substrate thereby forming an exposed portion of the semiconductor substrate within the cavity. A dopant is implanted into the exposed portion of the semiconductor substrate within the cavity thereby creating a dopant implanted exposed portion of the semiconductor substrate within the cavity. A semiconductor layer is epitaxially grown within the cavity atop the dopant implanted exposed portion of the semiconductor substrate.
US08420458B2 Semiconductor device and method of producing same
A semiconductor device has a planarizing layer that is made of an inorganic film, and has a recessed portion formed in a region thereof in which a conductive film is disposed. A first contact hole penetrating through at least an interlayer insulating film is formed on a first wiring layer, while a second contact hole penetrating through at least the interlayer insulating film is formed on the conductive film so as to run through the inside of the recessed portion.
US08420451B2 Manufacturing method of semiconductor device
Performing electrolysis plating to a wiring is made possible, aiming at the increasing of pin count of a semiconductor device. Package substrate 3 by which ring shape common wiring 3p for electric supply was formed in the inner area of bonding lead 3j in device region 3v of main surface 3a is used. Since a plurality of first plating lines 3r and fourth plating lines 3u for electric supply connected to common wiring 3p can be arranged by this, the feeder for electrolysis plating can be arranged to all the land parts on the back. Hereby, it becomes possible to perform electrolysis plating to the wiring of main surface 3a of package substrate 3, and the back surface.
US08420434B2 Solid-state imaging device and method of manufacturing solid-state imaging device
A solid state imaging device having a back-illuminated type structure in which a lens is formed on the back side of a silicon layer with a light-receiving sensor portion being formed thereon. Insulating layers are buried into the silicon layer around an image pickup region, with the insulating layer being buried around a contact layer that connects an electrode layer of a pad portion and an interconnection layer of the surface side. A method of manufacturing such a solid-state imaging device is also provided.
US08420433B2 Tiled light sensing array
A method is provided of forming a light sensing arrangement for use in a light sensor. The method comprises tiling a plurality of individual light sensing elements on a carrier, each element having a notch formed in an edge thereof, the notch being adapted to provide space, when the elements are tiled together, for an electrical connection to be made between the carrier and a surface of the element arranged to faced away from the carrier. Each element may comprise Silicon Photomultiplier (SPM) circuitry.
US08420431B2 Solar cell
A method of fabricating a solar cell includes steps of: forming an amorphous carbon layer, an AlN layer and a first n-type nitride semiconductor layer on the surface of the graphite substrate, forming a mask layer with a plurality of openings on the first n-type nitride semiconductor layer; forming a plurality of second n-type nitride semiconductor layers on the portions of the first n-type nitride semiconductor layer which are exposed by the plurality of openings; forming a plurality of light absorption layers on the plurality of second n-type nitride semiconductor layers; forming a plurality of p-side nitride semiconductor layers on the plurality of the light absorption layers; forming a p-side electrode; and forming an n-side electrode.
US08420427B2 Methods for implementation of a switching function in a microscale device and for fabrication of a microscale switch
Methods for Implementation of a Switching Function in a Microscale Device and for Fabrication of a Microscale Switch. According to one embodiment, a method is provided for implementing a switching function in a microscale device. The method can include providing a stationary electrode and a stationary contact formed on a substrate. Further, a movable microcomponent suspended above the substrate can be provided. A voltage can be applied between the between a movable electrode of the microcomponent and the stationary electrode to electrostatically couple the movable electrode with the stationary electrode, whereby the movable component is deflected toward the substrate and a movable contact moves into contact with the stationary contact to permit an electrical signal to pass through the movable and stationary contacts. A current can be applied through the first electrothermal component to produce heating for generating force for moving the microcomponent.
US08420425B2 Method for producing a group III nitride semiconductor light-emitting device
The present invention provides a method for producing a Group III nitride semiconductor light-emitting device whose driving voltage is reduced. In the production method, a p cladding layer has a superlattice structure in which a p-AlGaN layer having a thickness of 0.5 nm to 10 nm and an InGaN layer are alternately deposited. A growth temperature of the p-AlGaN layer is 800° C. to 950° C. The InGaN layer having a thickness of one to two monolayers is formed on the p-AlGaN layer, by stopping the supply of TMA, introducing TMI, and increasing the supply amount of Ga source gas while maintaining the p-AlGaN layer at the growth temperature. Thus, the thickness of the p cladding layer can be reduced while maintaining good crystal quality, thereby reducing the driving voltage.
US08420419B2 Group-III nitride semiconductor laser device, and method for fabricating group-III nitride semiconductor laser device
A method of fabricating a III-nitride semiconductor laser device includes: preparing a substrate product, where the substrate product has a laser structure, the laser structure includes a semiconductor region and a substrate of a hexagonal III-nitride semiconductor, the substrate has a semipolar primary surface, and the semiconductor region is formed on the semipolar primary surface; scribing a first surface of the substrate product to form a scribed mark, the scribed mark extending in a direction of an a-axis of the hexagonal III-nitride semiconductor; and after forming the scribed mark, carrying out breakup of the substrate product by press against a second region of the substrate product while supporting a first region of the substrate product but not supporting the second region thereof, to form another substrate product and a laser bar.
US08420417B2 Light emitting device and method of manufacture
A method of making a light emitting device includes forming an active layer between first and semiconductor layers of different conductivity types, and forming a transparent conductive layer adjacent the second semiconductor layer. The transparent conductive layer includes a first transparent conductive region contacting a first region of the second semiconductor layer and a second transparent conductive region contacting a second region of the second semiconductor layer. An electrode is formed adjacent the first semiconductor layer in vertical alignment with the second region.
US08420413B2 Method for manufacturing pixel structure
A pixel structure including a scan line, a data line, an active device, a shielding electrode, and a pixel electrode is provided on a substrate. The data line includes an upper conductive wire and a bottom conductive wire. The upper conductive wire is disposed over and across the scan line. The bottom conductive wire is electrically connected to the upper conductive wire. The active device is electrically connected to the scan line and the upper conductive wire. The shielding electrode is disposed over the bottom conductive wire. The pixel electrode disposed over the shielding electrode is electrically connected to the active device. In addition, parts of the pixel electrode and parts of the shielding electrode form a storage capacitor.
US08420410B2 Techniques providing fiducial markers for failure analysis
A semiconductor die includes a group of spacer cells within the semiconductor die. The spacer cells include fiducial markings therein. The fiducial markings can be located within a metal layer, a diffusion layer, a polysilicon layer, and/or a Shallow Trench Isolation (STI) structure.
US08420409B2 Method for manufacturing semiconductor device
An object is to provide a highly reliable semiconductor device that has tolerance to external stress and electrostatic discharge. Another object is to prevent defective shapes and defective characteristics due to the external stress or an electrostatic discharge in the manufacturing process, and to manufacture a semiconductor device with high yield. Still another object is to manufacture a semiconductor device at low cost and with high productivity. With the use of a conductive shield, electrostatic breakdown (malfunctions of the circuit or damages of a semiconductor element) due to electrostatic discharge of the semiconductor integrated circuit is prevented. The conductive shield is formed so that at least the conductive shields on the top and bottom surfaces are electrically connected by a plating method. In addition, a semiconductor device can be formed at low cost with high productivity because a plating method is used for the formation of the conductive shield.
US08420408B2 Semiconductor memory and manufacturing method thereof
A method for manufacturing a semiconductor memory device includes sequentially depositing a bottom electrode layer, a magnetic tunnel junction (MTJ) layer, a first top electrode layer, a second top electrode layer and a mask layer, etching the mask layer and forming a mask pattern, etching the second top electrode layer and the first top electrode layer by using the mask pattern as an etch barrier, etching the MTJ layer by using the mask layer and the second top electrode layer as an etch barrier, and etching the bottom electrode layer by using the first top electrode layer as an etch barrier.
US08420406B2 Method for analysing metabolites
Described is a method for analyzing the metabolites of a biological sample which comprises quantitatively determining one or more metabolites in said sample in a way that said quantitative determination resolves isotopic mass differences within one metabolite, said method being characterized in that the sample comprises or is derived from a cell which has been maintained under conditions allowing the uptake of an isotopically labeled metabolizable compound so that the metabolites in said cell are saturated with the isotope with which said metabolizable compound is labeled. This method may further comprise, prior to quantitative determining the metabolites, combining the biological sample (i.e. the first biological sample) with a second biological sample in which the metabolites are not isotopically labeled or are isotopically labeled differently from the first biological sample; and determining in said biological samples the relative quantity of metabolites which differ by their isotopical label. Furthermore described is a set of isotopically labeled metabolites obtainable by applying this method, as well as kits facilitating the application of this method and corresponding uses.
US08420395B2 Methods of unidirectional, site-specific integration into a genome, compositions and kits for practicing the same
The subject invention provides a unidirectional site-specific integration system for integrating a nucleic acid into the genome of a target cell. The provided systems include a (1) a mutant, unidirectional site specific integrase, which can be provided by an integrase vector encoding the mutant integrase and (2) a targeting vector that includes: (a) a nucleic acid to be integrated; and (b) a vector attachment site, where the targeting vector attachment site serves as a substrate for the mutant, unidirectional site-specific integrase. In using the subject systems for site-specific integration, the targeting vector and integrase are introduced into the target cell and the cell is maintained under conditions sufficient to provide for site-specific integration of the nucleic acid into the target cell genome via a recombination event mediated by the site-specific integrase. Also provided are kits that include the subject systems. The subjects systems, methods and kits find use in a variety of different applications, several representative ones of which are described in detail as well.
US08420392B2 Method for culturing human periosteum
The present invention provides a method for forcingly culturing a piece of human periosteum tissue in a shorter culture period, the method including the steps of: (1) placing a periosteum piece dissected from a patient on a culture dish containing no culture solution; (2) dropping platelet-rich plasma collected from the patient onto the surface of the periosteum piece on the culture dish and coagulating the platelet-rich plasma so as to cover the surface of the periosteum piece; (3) adding a first culture medium to the culture dish and growing the culture; and (4) growing the culture in a second culture medium containing a basic fibroblast growth factor and no platelet-rich plasma, after the step (3).
US08420391B2 RNA sequence-specific mediators of RNA interference
The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long dsRNA. Thus, these 21-23 nt fragments are the sequence-specific mediators of RNA degradation. A molecular signal, which may be their specific length, must be present in these 21-23 nt fragments to recruit cellular factors involved in RNAi. This present invention encompasses these 21-23 nt fragments and their use for specifically inactivating gene function. The use of these fragments (or chemically synthesized oligonucleotides of the same or similar nature) enables the targeting of specific mRNAs for degradation in mammalian cells, where the use of long dsRNAs to elicit RNAi is usually not practical, presumably because of the deleterious effects of the interferon response. This specific targeting of a particular gene function is useful in functional genomic and therapeutic applications.
US08420389B2 Nipah virus vaccines
The present invention relates to recombinant anti-Nipah virus vaccines and the administration of such vaccines to animals, advantageously pigs. Advantageously, the anti-Nipah virus vaccine may comprise a recombinant avipox virus containing a Nipah virus glycoprotein gene. The invention encompasses methods of vaccinating animals, advantageously pigs, by administration of anti-Nipah virus vaccines that may comprise a recombinant avipox virus that may contain a Nipah virus glycoprotein gene.
US08420386B2 Transposon-based targeting system
The present invention relates to a targeting system comprising, preferably as distinct components (a) a transposon which is devoid of polynucleotide encoding a functional transposase comprising (aa) a polynucleotide of interest and; (ab) a DNA sequence specifically recognized by a DNA binding domain; and (ba) a fusion protein comprising (i) said DNA binding domain; or (ii) a (poly)peptide binding domain binding to a (poly)peptide comprising said DNA binding domain; and (iii) a DNA targeting domain; or (iv) a (poly)peptide binding domain that binds to a cellular or engineered (poly)peptide that comprises a DNA targeting domain; or (bb) a polynucleotide encoding the fusion protein of (ba); and (ca) a transposase or a fragment or derivative thereof having transposase function; or (cb) a polynucleotide encoding the transposase or fragment or derivative thereof having transposase function of (ca).
US08420384B2 Apparatus for making a solid nutrient medium and associated method
The present invention provides an apparatus comprised of devices for simple, fast and cost-effective storage and plating of solid nutrient medium (SNM) for various uses in the field of microbiological analysis. The devices consist of a container which can be aseptically filled with SNM and equipped with a plunger to accurately press out needed amounts of the SNM; a cutting means to cut, hold and transfer SNM; a measuring means to measure the amount of SNM exiting the container; and a growth plate for storage of SNM, growth of microorganisms on SNM, and introduction of indicator substances to SNM for analysis of microorganisms.
US08420382B2 Acoustic wave biosensor for the detection and identification of characteristic signaling molecules in a biological medium
An acoustic wave biosensor comprises a plurality of spaced apart electrodes disposed on a substrate of piezoelectric material and having a biolayer matched to a specific type of autoinducer signaling molecule to be detected. The biolayer comprises a layer of heterobifunctional molecules disposed on the electrodes and on the piezoelectric material between the electrodes, and a plurality of bioreceptor molecules which bind exclusively with the specific type of autoinducer signaling molecule to be detected. The bioreceptor molecules are supported by the layer of heterobifunctional molecules, and a hydrogel layer surrounds the bioreceptor molecules to support a three-dimensional structure thereof. The bioreceptor molecules can bind with the specific type of autoinducer signaling molecule to be detected, and the biolayer is reactive thereto such that corresponding autoinducer signaling molecules bind to the biolayer and detectably vary acoustic characteristics of the acoustic wave biosensor.
US08420381B2 Apparatus and method for maintaining and/or restoring viability of organs
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
US08420379B2 Material for capturing microbes, device for capturing microbes, method of capturing microbes, and method of producing material for capturing microbes
The invention relates to a material for capturing microbes or the like, a device for capturing microbes or the like, a method of capturing microbes or the like, and a method of producing a material for capturing microbes or the like, and has an object of using a pulverizable resin whereby a minor amount of microbes or the like contained in a large amount of a liquid, or microbes or the like contained in a small amount of a liquid can be captured efficiently, quickly, labor-savingly, and reliably. Disclosed is: a material for capturing microbes or the like, which comprises irregular-shaped powdery grains made of a pulverizable adsorbent resin and distributed in a predetermined grain size range, and which can adsorb or bond to a target such as a microbe contained in a liquid; a device for capturing microbes or the like; and a method of capturing microbes or the like.
US08420377B2 Transgenomic mitochondria, transmitochondrial cells and organisms, and methods of making and using
The invention provides transgenomic mitochondria, transmitochondrial cells and organisms, and the materials and methods for making such mitochondria, cells, and organisms.
US08420375B2 Microorganisms and methods for carbon-efficient biosynthesis of MEK and 2-butanol
A non-naturally occurring microbial organism has at least one exogenous nucleic acid encoding a MEK pathway enzyme expressed in a sufficient amount to produce MEK. The MEK pathway includes an enzyme selected from an acetoacetyl-CoA dehydrogenase (bifunctional), an acetoacetyl-CoA aldehyde dehydrogenase, a 3-oxobutyraldehyde reductase, a 3-oxobutanol dehydratase, an MEK oxidoreductase, a 3-oxobutyraldehyde aminotransferase, a 4-aminobutan-2-one deaminase, a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP aminotransferase, a 2,4-dioxopentanoate decarboxylase, an AKP deaminase, an acetylacrylate decarboxylase, an AKP decarboxylase, a glutamate dehydrogenase, a 3-oxobutyraldehyde oxidoreductase (aminating) and an AKP oxidoreductase (aminating). A 2-butanol pathway further includes an MEK reductase. A method for producing MEK or 2-butanol includes culturing these organisms under conditions and for a sufficient period of time to produce MEK or 2-butanol.
US08420374B2 Helicobacter system and uses thereof
Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. In some embodiments, the Helicobacter provides exposure of a desired molecule of interest though the surface of the Helicobacter, providing exposure of the antigen to the host at the gastric mucosa. Live Helicobacter pylori vaccines are also provided. Vectors and shuttle vector constructs of the Helicobacter are also disclosed.
US08420372B2 Porcine adeno-associated viruses
Porcine tissues were screened for the presence of Adeno-Associated Viruses (AAV). Several AAV sequences were isolated from various porcine tissues, and BLAST analysis confirmed high to low homology with known AAV sequences of different origin. Sequence analysis confirmed the isolation of at least three novel porcine AAV isolates which we named AAVpo1, -po2, and -po3. Novel AAVs derived from porcine tissues may significantly contribute to the generation of new preventive or curative clinical modalities acceptable for human use.
US08420370B2 Alpha-amylase variants
The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular reduced capability of cleaving a substrate close to the branching point, and improved substrate specificity and/or improved specific activity relative to the parent alpha-amylase.
US08420368B2 Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof
This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the lysosomal sulfatase enzyme.
US08420361B2 Clostridium sporosphaeroides for the treatment of biomass
A method of treatment of biomass is described, characterized in that a microorganism of the species Clostridium sporosphaeroides is added to the biomass.
US08420358B2 Method for the combined production of butanol and hydrogen
The invention relates to a process for the combined production of butanol and hydrogen from biomass, comprising the steps of fermenting biomass to obtain butanol in a first reaction mixture; removing the butanol and hydrogen from the first reaction mixture to obtain effluent; and using the effluent as a substrate in a second reaction mixture in a process using low substrate concentrations, in particular a hydrogen production process. Preferably, the process using low substrate concentrations is a hydrogen production process and at least part of the end products of the hydrogen production process is removed from the second reaction mixture for obtaining an effluent that comprises organic acid, which effluent is returned to the first reaction mixture.
US08420357B2 Recombinant microorganism capable of producing polylactate or polylactate copolymer from sucrose and method for producing polylactate or polylactate copolymer from sucrose using the same
Provided are a microorganism capable of producing a polylactate (PLA) or PLA copolymer from sucrose and a method of producing the PLA or PLA copolymer from sucrose using the same. A gene of an enzyme converting lactate into lactyl-CoA and a gene of a polyhydroxyalkanoate (PHA) synthase using lactyl-CoA as a substrate are introduced into a microorganism capable of using sucrose as a substrate, and the microorganism is cultured using sucrose as the substrate, thereby allowing efficient production of a PLA or PLA copolymer.
US08420349B2 Enzymatic modification of oil
The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated fatty acid in an oil composition.
US08420348B2 Antibodies for the detection of integrin complexes in FFPE material
The invention relates to antibodies that are capable to bind the extracellular domain of integrin. Another object of the invention concerns the use of said antibodies for detecting integrins in archival formalin fixed paraffin embedded (FFPE) tissue. The invention also relates to methods for preparing monoclonal rabbit antibodies, wherein the immunogen is an insect expression culture-derived recombinant extracellular integrin domain, and another method for screening anti-integrin antibodies that discriminate between closest integrin homologues and that are especially suited for immunohistochemistry in FFPE material.
US08420345B2 Method for identifying at least two groups of microorganisms
The present invention relates to a method for identifying at least two groups of microorganisms expressing the same enzymatic activity, comprising the following steps: a) incubating said groups of microorganisms in a reaction medium comprising a first enzyme substrate and a second enzyme substrate, said first and second enzyme substrates being metabolized by the same enzymatic activity; b) identifying said groups of microorganisms.
US08420344B2 Fatty acid pattern analysis for predicting acute coronary syndrome
The present invention provides blood based methods for predicting risk of acute coronary syndrome in a subject.
US08420341B2 Methods for measuring ADP
This invention relates to assays for detecting and measuring ADP. In particular, this invention provides homogeneous luminescent assays that detect ADP generation and measures ADP accumulation based on enzymatic coupling reactions. The assays of the present invention can be applied to all types of kinases and other ADP-generating enzymes, are antibody free, beads free, radioisotope free, and compatible with commonly used kinase buffers.
US08420337B2 Lipoprotein-associated markers for cardiovascular disease
The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop, or is suffering from, cardiovascular disease. The methods comprise detecting an amount of at least one biomarker in a biological sample, or HDL subfraction thereof, from the subject, and comparing the detected amount of the biomarker to a predetermined value, where a difference between the detected amount and the predetermined value is indicative of the presence or risk of cardiovascular disease in the subject. In some embodiments, the biomarker comprises at least one of ApoC-IV, Paraoxonase 1, C3, C4, ApoA-IV, ApoE, ApoL1, C4B1, Histone H2A, ApoC-II, ApoM, Vitronectin, Haptoglobin-related protein, and Clusterin, or combinations thereof.
US08420336B2 Method of bioassaying yokukansan
An in-vitro bioassay method for yokukansan, involving competitively binding a labeled ligand and yokukansan with cells or cell membranes expressing glutamate receptors, measuring the binding activity of yokukansan, and determining the pharmacological activity of yokukansan from the measurement.
US08420330B2 Diagnosis and treatment of cardiac troponin 1 (cTn1) autoantibody-mediated heart disease
Provided herein are, inter alia, methods of diagnosing and treating autoimmune cardiomyopathy in subjects, based upon the detection of IgG4 autoantibodies to cardiac troponin I (cTnI).
US08420325B2 Thermostable polymerases having altered fidelity and methods of identifying and using same
The present invention provides a method for identifying a thermostable polymerase having altered fidelity. The method consists of generating a random population of polymerase mutants by mutating at least one amino acid residue of a thermostable polymerase and screening the population for one or more active polymerase mutants by genetic selection. For example, the invention provides a method for identifying a thermostable polymerase having altered fidelity by mutating at least one amino acid residue in an active site O-helix of a thermostable polymerase. The invention also provides thermostable polymerases and nucleic acids encoding thermostable polymerases having altered fidelity, for example, high fidelity polymerases and low fidelity polymerases. The invention additionally provides a method for identifying one or more mutations in a gene by amplifying the gene with a high fidelity polymerase. The invention further provides a method for accurately copying repetitive nucleotide sequences using a high fidelity polymerase mutant. The invention also provides a method for diagnosing a genetic disease using a high fidelity polymerase mutant. The invention further provides a method for randomly mutagenizing a gene by amplifying the gene using a low fidelity polymerase mutant.
US08420320B2 Method for rapid identification of microorganisms
The present invention relates, in general, to probes, methods, and kits used to determine the presence or absence of a microorganism in a sample. The probes, methods, and kits comprise at least one capture probe and/or at least one detector probe.
US08420318B2 Microfabricated integrated DNA analysis system
Methods and apparatus for genome analysis are provided. A microfabricated structure including a microfluidic distribution channel is configured to distribute microreactor elements having copies of a sequencing template into a plurality of microfabricated thermal cycling chambers. A microreactor element may include a microcarrier element carrying the multiple copies of the sequencing template. The microcarrier element may comprise a microsphere. An autovalve at an exit port of a thermal cycling chamber, an optical scanner, or a timing arrangement may be used to ensure that only one microsphere will flow into one thermal cycling chamber wherein thermal cycling extension fragments are produced. The extension products are captured, purified, and concentrated in an integrated oligonucleotide gel capture chamber. A microfabricated component separation apparatus is used to analyze the purified extension fragments. The microfabricated structure may be used in a process for performing sequencing and other genetic analysis of DNA or RNA.
US08420311B2 Method to block the infection by flaviviruses, molecules and uses
The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
US08420307B2 Sperm cryoprotective media
Described herein is a composition that comprises a cryoprotectant; a membrane protectant that stabilizes or assists in stabilization of membranes of sperm; and a free radical scavenger (e.g., a reducing agent, an antioxidant).
US08420303B2 Substrate processing method, computer-readable storage medium and substrate processing system
A PEB unit has a first heat plate and a second heat plate. After an exposure process for a resist film for EUV on a wafer and before a development process, the PEB unit heats the wafer through the first heat plate at a first heating temperature. A heating time through the first heat plate is not less than 10 seconds and not more than 30 seconds. Thereafter, the PEB unit heats the wafer through the second heat plate at a second heating temperature lower than the first heating temperature. A temperature difference between the first heating temperature and the second heating temperature is not less than 20° C. and not more than 60° C.
US08420287B2 Positive photosensitive resin composition
Disclosed is a positive photosensitive resin composition that includes: (A) a polybenzoxazole precursor including a repeating unit represented by the Chemical Formula 1, a repeating unit represented by the Chemical Formula 2, or a combination thereof, and a thermally polymerizable functional group at least one terminal end of the polybenzoxazole precursor; (B) a photosensitive diazoquinone compound; (C) a silane compound; (D) a phenol compound including a cross-linking functional group; and (E) a solvent.
US08420286B2 Toner process
The present disclosure provides processes for preparing toner particles, in which fewer coarse particles are generated. The process includes introducing a buffer solution during coalescence of the toner slurry. The amount of coarse particles in the resulting toner particles may, in embodiments, be reduced to less than about 5 percent by weight of the total toner particles generated.
US08420280B2 Hologram recording medium
The present invention provides a hologram recording medium which can attain high refractive index change, flexibility, high sensitivity, low scattering, environment resistance, durability, low dimension change (low shrinkage) and high multiplicity in holographic memory record using a blue laser. A hologram recording medium (11) comprising at least a hologram recording material layer, wherein the hologram recording material layer (21) comprises at least a metal oxide and a photopolymerizable compound; and said hologram recording medium has a light transmittance of 50% or more at a wavelength of 405 nm, or a light reflectance of 25% or more at a wavelength of 405 nm.
US08420274B2 Membrane electrode assembly for fuel cell, method of manufacturing the same, and fuel cell including the membrane electrode assembly
A membrane electrode assembly for a fuel cell, includes: an electrolyte membrane, and cathode and anode that are respectively disposed on opposing surfaces of the electrolyte membrane, wherein the anode comprises an anode catalyst layer, an anode micro-porous layer and an anode diffusion support that are sequentially disposed on one surface of the electrolyte membrane, wherein the thickness ratio of the anode catalyst layer to the anode micro-porous layer is in a range of 1:0.82 to 1:3.28, and the thickness ratio of the anode catalyst layer to the anode diffusion support is in a range of 1:5 to 1:7.05.
US08420270B2 Fuel cell system
A fuel cell system capable of restraining temperature change in a fuel cell caused by a refrigerant. The fuel cell system has a refrigerant circulating system for circulating the refrigerant. The refrigerant circulating system has flow control means for restraining the inflow of the refrigerant, which has a predetermined difference in temperature from that of the fuel cell, into the fuel cell.
US08420265B2 Electrolyte for rechargeable lithium battery and rechargeable lithium battery including the same
Disclosed is an electrolyte for a rechargeable lithium battery that includes a lithium salt, a phosphine compound having at least one trialkylsilyl group and organic solvent, and a rechargeable lithium battery including the electrolyte. The phosphine compound may be tris(trialkylsilyl)phosphine wherein the alkyl groups are the same or different and are each independently selected from C1 to C6 alkyl.
US08420262B2 Nonaqueous electrolyte battery, battery pack and vehicle
A nonaqueous electrolyte battery includes a negative electrode and a positive electrode. The negative electrode includes a negative electrode current collector and a negative electrode active material having a lithium ion absorption potential of 0.4 V (vs. Li/Li+) or more. The negative electrode current collector is made of aluminum or an aluminum alloy. The positive electrode includes a positive electrode current collector and a positive electrode active material. The positive electrode current collector has a total area and specific capacitance larger than those of the negative electrode current collector, and is made of aluminum or an aluminum alloy.
US08420261B2 Thin film alloy electrodes
Thin film alloy electrodes are provided that are useful as negative electrodes in lithium-ion electrochemical cells. The alloys include aluminum and at least one additional electrochemically active metal or composite. They can be used as a current collector or as a complete electrode.
US08420257B2 Cap assembly comprising gasket prevented from sagging and cylindrical secondary battery comprising the same
A cap assembly is provided. The cap assembly comprises a main gasket surrounding the outer circumference of a safety vent and an auxiliary gasket surrounding the outer circumference of a current interrupt device (CID). The main gasket is supported by the auxiliary gasket, leaving no space between the main gasket and the safety vent. The cap assembly is constructed such that the auxiliary gasket prevents the main gasket seated on a beading portion from sagging. This construction makes the cap assembly effective in preventing an electrolyte from leaking. Further provided is a cylindrical secondary battery comprising the cap assembly.
US08420254B2 End cover assembly for an electrochemical cell
An end cover assembly for a battery comprises a cover plate; a scabbard mounted on the cover plate; a connector; and a sealing material. The cover plate comprises an opening. The scabbard comprises an interior channel. The opening is in communication with the channel. The connector is disposed in the interior channel and protrudes from the scabbard. The sealing material is disposed in the interior channel and extends beyond the upper portion of the scabbard and wraps around the outside of the scabbard to form a protective flange.
US08420252B2 Battery layout incorporating full metal edge seal
A first current collector on the first surface of the substrate and a second current collector having a first surface and a perimeter. One of the first and second current collector is an anode current collector and the other is a cathode current collector. The battery also comprises a cathode material having a perimeter, the cathode material being located on the cathode current collector; an electrolyte layer having a perimeter, the electrolyte separating the cathode material from the anode current collector; an insulation layer having a perimeter, the insulation layer together with the electrolyte layer separating the anode current collector from the cathode material and the cathode current collector. A first passivation layer generally overlies at least the perimeter of the cathode material, the perimeter of the electrolyte, and the perimeter of the insulation layer, the first passivation layer being electrically coupled to the first current collector and forming a continuous metal to metal seal around a defined area of the first current collector. The first passivation layer has a via opening. A second passivation layer is electrically coupled to the second current collector through the via opening of the first passivation layer.
US08420250B2 Battery module and battery pack including the same
A battery module and battery pack, the battery module including a pair of end plates facing each other; a plurality of battery units arranged in a first direction between the end plates; a first side plate extending along a first side of the plurality of battery units, the first side plate being coupled to the end plates; a second side plate extending along a second side of the plurality of battery units, the second side plate being coupled to the end plates and being disposed opposite to the first side plate; a first coupling member, the first coupling member coupling the end plates to the first side plate; and a second coupling member, the second coupling member coupling the end plates to the second side plate, wherein the first coupling member and the second coupling member are disposed in asymmetrical positions with respect to a central line of the end plates.
US08420247B2 Crosslinking polymer-supported porous film for battery separator and use thereof
The present invention relates to a crosslinking polymer-supported porous film for battery separator, including: a porous film; and a crosslinking polymer supported on the porous film, the crosslinking polymer having a plurality of cation-polymerizable functional groups in the molecule thereof and having oxyalkylene groups represented by general formula (I): in which the Rs may be the same or different and each independently represent a hydrogen atom or a methyl group, and n represents an integer of 4 to 9, in a side chain thereof.
US08420246B2 Electronic device with sliding battery cover
An electronic device with sliding battery cover includes a housing, a battery holder formed in the housing, a fixing element rotatably connected to the battery holder, and a battery cover slidably connected to the fixing element to cover or uncover the battery holder. The battery holder is for placing at least one battery. The fixing element includes at least one conductive elastic element. When the battery cover covers the battery holder, each conductive elastic element contacts an electrode of one of the at least one battery placed in the battery holder, and the battery cover is locked to the battery holder; when the battery cover is to uncover the battery holder, a force applied to the battery cover makes the battery cover slide along the fixing element to unlock the battery cover from the battery holder.
US08420244B2 Battery pack configured for enhanced operation in a cold environment
A battery pack includes a battery compartment, a terminal plate positioned within the battery compartment for retaining at least two batteries within the battery compartment, and a cover for enclosing the battery compartment, wherein, upon enclosing the battery compartment with the cover, the cover is configured to urge an exterior surface of one of the at least two batteries against an exterior surface of another of the at least two batteries to establish both physical and thermal contact between the at least two batteries.
US08420242B2 Cell module
A cell module has a cell group with a plurality of cells connected to each other. The module comprises a bus bar plate including a bus bar connecting between the cells and an end cover for covering the bus bar plate. The cell module is configure to be fixed with the end cover.
US08420236B2 Magnetic semiconductor material
A magnetic semiconductor material contains at least one type of transition metals (Mn2+, Fe3+, Ru3+, Re2+, and Os3+) having five electrons in the d atomic orbital as a magnetic ion, in which the magnetic semiconductor material exhibits n-type electrical conduction by injection of an electron carrier and p-type electric conduction by injection of a hole carrier. A specific example is a layered oxy-pnictide compound represented by LnMnOPn (wherein Ln is at least one type selected from Y and rare earth elements of La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu, and Pn is at least one selected from pnicogen elements of N, P, As, Bi, and Sb). A high-sensitivity magnetic sensor, current sensor, or memory device can be made by using a magnetic pn homojunction structure made of thin films composed of the magnetic semiconductor material.
US08420232B2 Binaphthyl-arylamine polymers
Disclosed are Binaphthyl-Arylamine Polymers having Formula I: In the Formula: Ar1 is an arylene; Ar2 is an aryl group; Ar3 is an arylene; Binap is a binaphthyl moiety; M is a conjugated moiety; and x, y and z are mole fractions such that x+y+z=1.0, with the proviso that x and y are not zero.
US08420227B2 Composite material, light emitting element and light emitting device
An object of the present invention is to provide a composite material formed of an organic compound and an inorganic compound, and has an excellent carrier transporting property, an excellent carrier injecting property to the organic compound, as well as excellent transparency. A composite material of the present invention for achieving the above object is a composite material of an organic compound represented in the general formula below, and an inorganic compound. For the inorganic compound, an oxide of a transition metal, preferably an oxide of a metal belonging to groups 4 to 8 of the periodic table, in particular vanadium oxide, tantalum oxide, molybdenum oxide, tungsten oxide, rhenium oxide, and ruthenium oxide, can be used.
US08420226B2 Welded structural member and method and use thereof
A structural member comprising at least two aluminum alloy parts displaying different property balances, said at least two parts being welded and wherein one of said parts either is (i) selected from an aluminum alloy different from the other of said at least two parts and/or (ii) is selected from an initial temper different from the other of said at least two parts, and wherein at least one of said at least two parts has been pre-aged prior to being welded, and, wherein said structural member has undergone a post-welding thermal treatment conferring a final temper to each of said at least two parts. The parts are advantageously welded by friction stir welding. Another subject of the invention is a method for manufacturing a structural member.
US08420220B2 Rubber composition
A rubber composition comprising 0.3 to 10 parts by mass of sulfur and 0.1 to 10 parts by mass of a sulfeneamide base vulcanization accelerator represented by the following Formula (I) based on 100 parts by mass of a rubber component: (wherein R1 to R10 are a hydrogen atom, a linear alkyl group having 1 to 4 carbon atoms or a branched alkyl group having 3 to 4 carbon atoms, and they may be the same or different; R11 is a hydrogen atom, a linear alkyl group having 1 to 10 carbon atoms or a branched alkyl group having 3 to 10 carbon atoms; R12 to R15 are a hydrogen atom, a linear alkyl group or alkoxy group having 1 to 4 carbon atoms or a branched alkyl group or alkoxy group having 3 to 4 carbon atoms, and they may be the same or different; and x represents an integer of 1 or 2).
US08420218B2 Photovoltaic modules having reduced weight
The construction principles according to the present invention make possible large sheet-like solar modules with low weight, which have great mechanical toughness, are inured to rough climatic environment influences and withstand thermal stress due to solar irradiation and shadowing effects. The solar modules have front and back panes, one of which has a thickness of at least 3 mm and the other of which has a thickness of at most 2 mm. The coefficient of thermal expansion of the thicker pane is preferably greater than that of the thinner pane. In preferred embodiments burling or a wavy structure is provided on one side of the front pane and/or the back pane.
US08420217B2 Elastic bonding films
Elastic bonding films that include an elastic, thermoset core layer and a thermoplastic bonding layer on each side of the core layer are described. The thermoset core layer is a polyurethane formed as the reaction product of (i) a multifunctional isocyanate with (ii) a combination of polyols comprising (a) polyester diol, (b) crosslinker, and (c) hard segment. Articles incorporating such elastic bonding films including fabrics bonded to such films are also described.
US08420216B2 Thermosetting resin composition
The thermosetting resin composition according to the present invention includes a resin (A) containing two or more carboxyl groups and having a polyurethane structure, a strongly basic nitrogen-containing heterocyclic compound having pKa of 10.0 to 14.0 as a curing accelerator (B) and a curing agent (C). A cured product of the thermosetting resin composition is used as an insulating protective film for printed wiring boards, flexible printed wiring boards, chip-on-films, etc. The thermosetting resin composition of the invention has improved low-temperature curability and instantaneous curability, can realize tack-free property, can simultaneously realize low warpage property and electrical insulation property, does not contaminate a curing oven and the like by outgassing during heating, has a sufficient pot life, can form excellent cured products and insulating protective films, and can form solder resists and insulating protective films at low cost with good productivity.
US08420215B2 Cyclic process for the preparation of barium sulphate and lithium metal phosphate compounds
A cyclic process for the preparation of barium sulphate and lithium-iron phosphate comprising (i) preparing an aqueous solution containing lithium and sulphate ions and (ii) adding solid barium hydroxide at a temperature of more than 50° C., wherein the barium hydroxide is added over a period of less than 15 minutes. Also, barium sulphate obtainable by the process according to the invention.
US08420214B2 Acrylic pressure-sensitive adhesives with aziridine crosslinking agents
A pre-adhesive composition is described comprising an acid-functional (meth)acrylate copolymer and an aziridine crosslinking agent, which when crosslinked provides a pressure-sensitive adhesive and pressure-sensitive adhesive articles.
US08420213B2 Composite substrate and method for forming metal pattern
A composite substrate is a piezoelectric substrate that is transparent to light used for photolithography, and a supporting substrate for supporting the piezoelectric substrate are bonded together via an organic adhesive layer. Where at least one of the supporting substrate and the organic adhesive layer of the composite substrate absorbs light used for photolithography.
US08420212B2 Silane coupling agents with heat resistance, durability, releasability and antifouling property, and process for producing these compounds
Silane coupling agents which are high in heat resistance, and which are high in durability, releasability, and antifouling properties. The silane coupling agents have a biphenylalkyl group and are represented by the following general formula (1).
US08420211B2 Porous polyimide membrane and process for production of same
Disclosed is a porous polyimide membrane of a three-layer structure having two surface layers (a) and (b) and a macrovoid layer interposed between the surface layers (a) and (b), wherein the macrovoid layer has a partition wall joined to the surface layers (a) and (b) and plural macrovoids surrounded by the partition wall and the surface layers (a) and (b), with an average void diameter in a membrane plane direction of from 10 to 500 μm; each of the partition wall of the macrovoid layer and the surface layers (a) and (b) has a thickness of from 0.1 to 50 μm and has plural pores having an average pore diameter of from 0.01 to 5 μm, the pores being communicated with each other and also communicated with the macrovoids; and the membrane has a total membrane thickness of from 5 to 500 μm and a porosity of from 70 to 95%.
US08420203B2 Surface structure for a working device
The present invention relates to a surface structure for a working device. In particular, the invention relates to a surface structure for a working device that has at least one first element with a first height and a second element with a second height, and a third element having a third height, wherein the second height is greater than the third height, having in addition a first grip area, a second grip area, and a third grip area, wherein the elements are arranged on a dot matrix, wherein the centers of the second elements and the centers of the third elements are arranged on the points of intersection and the centers of the first elements are not arranged on the points of intersection, and the first grip area comprises first elements and second elements, the second grip area comprises predominantly second elements, the third grip area comprises predominantly third elements. The present invention also relates to a working device having such a surface structure.
US08420194B2 Rotomoulded articles prepared with polyethylene
The present invention is concerned with rotomoulded articles having very low warpage and shrinkage and consisting essentially of polyethylene prepared with a catalyst system based on a bis-indenyl or on a bis(n-butyl-cyclopentadienyl)metallocene component.
US08420192B2 Silica container and method for producing the same
A method for producing a silica container comprising: forming a preliminarily molded substrate, wherein a first powdered raw material is fed to an inner wall of an outer frame having aspiration holes while rotating the outer frame; forming a preliminarily molded intermediate layer, wherein a second powdered raw material added with an aluminum compound or a crystal nucleating agent as an additive is fed to an inner wall of the preliminarily molded substrate; and forming an inner layer, wherein the preliminarily molded substrate and the preliminarily molded intermediate layer are degassed by aspiration from a peripheral side with heating from an inside thereby forming a substrate and an intermediate layer, and while a third powdered raw material having a high silica purity is spread from inside the substrate having the formed intermediate layer with heating from the inside thereby forming an inner layer on an inner surface of the intermediate layer.
US08420190B2 Packaging material for packaging of container having photosensitive composition filled therein
A packaging material for packaging a container having a photosensitive composition filled therein, which comprises a film having a transmittance of a light in a wavelength range of 200 nm to 500 nm of 5% or less and a transmittance of a light in a wavelength range of 620 nm to 940 nm of 10% or more.
US08420187B2 Cellulose acylate composition, cellulose acylate film, and its applications
A novel cellulose acylate composition is disclosed. The composition comprises at least one cellulose acylate having an aromatic group-containing acyl group (Substituent A), in which a substitution degree with Substituent A satisfies following relational expressions (I) and (II): DSA2+DSA3−DSA6>0.05,  (I) 0.11
US08420186B2 Method and apparatus of growing a thin film
A method and apparatus of growing a thin film are provided. The method comprises at least (a) providing a number of substrates; (b) cleaning the substrates; and (c) placing the substrates into a reaction liquid; (d) vibrating the reaction liquid by ultrasonic waves such that a thin film is grown on the substrates evenly.
US08420184B2 Method for preparing surface modification coating of metal bipolar plates
A method for preparing a surface modification coating of metal bipolar plates is disclosed, which comprises the following steps: providing a substrate; pre-treating the substrate by processing the substrate, depositing a Ni-layer on the substrate, or a combination thereof, to form an activated layer on the surface of the substrate; packing the substrate in a powder mixture containing a permeated master metal, an activator, and filler powder; and heat-treating the packing to allow the permeated master metal to diffuse into the activated layer and then to form a surface modification coating. The permeation rate of the permeated master metal can be increased due to the activated layer having a high defect concentration. Hence, it is possible to prepare a surface modification coating at a low temperature. The surface modification coating of the present invention can also decrease the interface contact resistance between the bipolar plates and gas diffusion layers.
US08420182B2 Method of manufacturing polymer dispersed liquid crystal display device including dichroic dye
Example embodiments relate to a method of manufacturing a polymer dispersed liquid crystal (PDLC) display device including dichroic dye. The method may include filling a mixture solution including liquid crystals, a photopolymerizable material, dichroic dyes, and liquid crystalline polymers in a space between a first electrode and a second electrode that face each other; applying an electric field between the first electrode and the second electrode; and arranging the dichroic dyes in the mixture solution.
US08420181B2 Method of producing microfluidic devices based on a polymer
Disclosed is a method for producing a polymer-based microfluidic device, including: forming a microstructure on a lower polymer matrix; coating the lower polymer matrix with TiO2 to perform patterning of TiO2; bonding the lower polymer matrix with an upper polymer matrix; and radiating UV lights thereto to convert TiO2-coated regions into hydrophilic regions. Disclosed also is a polymer-based microfluidic device obtained by the method. The method enables development of a microfluidic device having high stability and long-term durability.
US08420180B2 Electrostatic spray for coating aircraft engine components
Electrostatic deposition of high performance powdered materials onto gas turbine surfaces. The process also includes post-deposition thermal staging of the deposited powder to provide a durable coating that will satisfy the demands of turbine engine operation. The process envisions application of organic-based powdered materials, glass/ceramic powdered materials and metal-based powdered materials and combinations thereof using electrostatic techniques to components exposed to low temperature operations, such as may be found in the front section of a gas turbine engine or to the exterior portions of an aircraft engine, and metal-containing glass ceramics, glass-ceramic materials, or materials that can be transformed into glass ceramic materials, when applied to components exposed to high temperature operations, such as may be found in the turbine and exhaust sections of a gas turbine engine or the flaps of an aircraft.
US08420178B2 Liquid sending method and system
A liquid sending method comprises the steps of sending a coating solution to a liquid sending pipe, passing the coating solution to an orifice which is provided at a part of the liquid sending pipe to prevent a vibration propagation and passing the coating solution to a pulsation absorb device which is provided at a part of the liquid sending pipe where is located at a downstream of the orifice, wherein the pulsation absorb device includes a first chamber that a liquid can flow in and out, a second chamber which is introduced a gas, and a diaphragm which separates the first chamber and the second chamber.
US08420177B2 Method for preparing functional multilayer anisotropic conductive adhesive film
A functional multilayer anisotropic conductive adhesive film, capable of bonding and package 0.18-0.13 micron IC chips and high density COF, includes a monomer layer, a reinforcing layer, a low-temperature, hot-melt resin layer, and a conductive particle layer, successively bonded by coating and drying processes. The monomer layer comprises a copolymer of butyl acrylate, methyl acrylate, glycol acrylate, and tetramethyl butyl peroxy-2-ethyl hexanoate. The reinforcing layer comprises long chain imidazole derivatives. The hot-melt resin layer comprises polymer of tocopheroxyl, novolac epoxy, acrylic rubbers and elastic mixture of acrylic rubbers and styrene-butadiene rubbers. The conductive particle layer comprises conductive particles and micro-encapsulating resin for receiving the conductive particles. Diameter of the conductive particles is selected from the group consisting of 3.00 μm ±0.05, 3.25 μm±0.05, 3.50 μm±0.05, 3.75 μm±0.05 and 4.00 μm±0.05.
US08420172B1 Apparatus and method of manufacturing shingles from cellular polyvinyl chloride
A method for forming shingles from cellular polyvinyl chloride boards comprising brushing, parting, cutting and coating the boards to desired dimensions and finish. The method comprises passing cellular polyvinyl chloride boards through one or more of a specially designed brushing assembly, cross cut saw assembly, parting assembly, and sizing saw assembly, wherein the assemblies are in-line. The method may further include an in-line, high speed application and accelerated curing of a uniquely formulated solar reflective, ceramic-based finish.
US08420171B2 Forming heaters for phase change memories
A heater for a phase change memory may be formed by depositing a first material into a trench such that the material is thicker on the side wall than on the bottom of the trench. In one embodiment, because the trench side walls are of a different material than the bottom, differential deposition occurs. Then a heater material is deposited thereover. The heater material may react with the first material at the bottom of the trench to make Ohmic contact with an underlying metal layer. As a result, a vertical heater may be formed which is capable of making a small area contact with an overlying chalcogenide material.
US08420169B2 Method of manufacturing organic thin film
A thin film of a uniform film thickness is formed even without increasing the film deposition rate. The temperature of an evaporation device disposed in an evaporation chamber is raised in advance, and an organic material is dropped from a supply unit onto an evaporation surface of the evaporation device; and when the organic material is evaporated, a heated carrier gas is introduced into the evaporation chamber, and is mixed in the evaporation chamber and is introduced into a discharger. While a molecular flow is formed in the discharger in a case that only the organic material vapor is introduced into the discharger, the pressure within the discharger is raised due to the carrier gas, so that a viscous flow is formed and the mixed gas is filled in the discharger and is uniformly discharged. The organic material may be supplied by a small amount and the film deposition rate may not become too high.
US08420167B2 Method of manufacturing a semiconductor device
A method of manufacturing a semiconductor device includes the steps of: conveying a plurality of substrates disposed in a direction perpendicular to a substrate processing surface into a processing chamber provided inside of a reaction tube, with an outer periphery surrounded by a heating device; and processing the substrates by introducing gas to a gas inlet tube provided on a side face of the reaction tube in a region for processing the substrates inside the reaction tube, so as to reach at least an outside of the heating device, and spouting the gas into the processing chamber from a slit-shaped gas spouting port disposed in a form so as to straddle at least a plurality of the substrates in a direction perpendicular to the substrate processing surface.
US08420164B2 Solid type rubber-based pressure-sensitive adhesive composition and pressure-sensitive adhesive sheet thereof
The present invention relates to a solid type rubber-based pressure-sensitive adhesive composition, which is prepared by adding a tackifier, a softener, and an isocyanate-based crosslinking agent reactable with active hydrogen into an acrylic rubber containing a monomer having an active hydrogen-containing functional group as a copolymerization component to thereby obtain a solventless and nonaqueous pressure-sensitive adhesive composition, and particularly it relates to a solid type rubber-based pressure-sensitive adhesive composition having the above-mentioned constitution, in which the above-mentioned acrylic rubber includes a copolymer containing butyl acrylate as a main component, and as the copolymerization component a monomer having a hydroxyl group or a carboxyl group as the active hydrogen-containing functional group.
US08420162B2 Method of making coated article using rapid heating for reducing emissivity and/or sheet resistance, and corresponding product
This invention relates to a method of making a coated article for use in insulating glass (IG) window units, vehicle windows, or the like. The coated article typically includes a low-E coated article, including a low-E (low emissivity) coating supported by a glass substrate. In certain example embodiments, rapid heating (not sufficient for tempering or heat bending) of the coated article is utilized in order to reduce the emissivity and/or sheet resistance of the coated article without significantly damaging the infrared (IR) reflecting layer(s) of the coating, thereby activating the coated article. The glass of the coated article does not become too hot during such rapid heating.
US08420161B2 Method for producing anti-glare film
A method for producing an anti-glare film includes applying a coating composition including at least a resin, a solvent, and fine particles to a substrate; drying the coating composition applied to the substrate so that a Benard cell structure is formed in the surface of the coating layer due to convection caused during volatilization of the solvent; and curing the resin contained in the coating composition having formed therein a Benard cell structure to form an anti-glare layer having fine irregularities with a moderate surface waviness. The anti-glare layer has a degree of white muddiness of 1.7 or less, as measured by quantitatively determining a diffuse reflection component of the diffused light incident upon the surface of the anti-glare layer.
US08420160B2 Method for producing sintered NdFeB magnet
The present invention provides a method for producing a sintered NdFeB magnet having high coercivity and capable of being brought into applications without lowering its residual magnetic flux density or maximum energy product and without reprocessing. The method for producing a sintered NdFeB magnet according to the present invention includes applying a substance containing dysprosium (Dy) and/or terbium (Tb) to the surface of the sintered NdFeB magnet forming a base body and then heating the magnet to diffuse Dy and/or Tb through the grain boundary and thereby increase the coercivity of the magnet. This method is characterized in that: (1) the substance containing Dy or Tb to be applied to the surface of the sintered NdFeB magnet is substantially a metal powder; (2) the metal powder is composed of a rare-earth element R and an iron-group transition element T, or composed of R, T and another element X, the element X capable of forming an alloy or intermetallic compound with R and/or T; and (3) the oxygen content of the sintered NdFeB magnet forming the base body is 5000 ppm or lower. The element T may contain nickel (Ni) or cobalt (Co) to produce an anticorrosion effect.
US08420159B2 Method of fabricating magnetic head slider including partial removal step of protecting film
The method of fabricating a magnetic head slider includes steps of: forming a first protective film on an air bearing surface of a magnetic head slider on which either a recording element or a reproduction element is formed or on which both a recording element and a reproduction element are formed; removing a portion of the first protective film to reduce the thickness of the first protective film and forming a second protective film over the first protective film that has been reduced in thickness; and forming an uneven portion for controlling the flying characteristics of the magnetic head slider on the air bearing surface of the magnetic head slider; wherein the formation of the uneven portion is carried out after the first protective film has been formed and before the second protective film is formed, or after the second protective film has been formed.
US08420157B2 Electroluminescent device
An electroluminescent device comprises a hole injecting electrode, an electron injecting electrode and at least one organic light emitting layer disposed between said hole injecting electrode and said electron injecting electrode wherein a layered metal chalcogenide layer is disposed between said hole injecting electrode and said light emitting layer.
US08420156B2 Method of forming pattern and manufacturing method of organic light emitting device
A method of forming a pattern and a method of manufacturing an organic light emitting device, the method of forming a pattern including providing an electromagnetic substrate for generating an electromagnetic field at a selectively controllable position by selectively controlling where current flows through the electromagnetic substrate; providing a patterning substrate for forming a pattern; aligning the electromagnetic substrate to a first surface of the patterning substrate; selectively applying current to the electromagnetic substrate to form the electromagnetic field at the predetermined position; providing masking powder in a vicinity of a second surface of the patterning substrate such that the masking powder reacts to the electromagnetic field; supplying a pattern forming material to the second surface of the patterning substrate; and cutting off the current to the electromagnetic substrate.
US08420154B2 Method of manufacturing glass substrate and information recording medium
In a method of manufacturing a glass substrate for an information recording medium including a step for chemically strengthening the glass substrate by contacting the glass substrate with chemical strengthening processing liquid containing chemical strengthening salt, concentration of Fe and Cr is 500 ppb or less in said chemical strengthening salt, respectively. The concentration may be detected by the use of an ICP (Inductively Coupled Plasma) emission spectrometry analyzing method or a fluorescent X-ray spectroscopy analyzing method.
US08420148B2 Beverage whitening composition and method
A beverage whitening composition for replacing cream or milk in a reduced volume comprising: cream having a higher butter fat content than the cream or milk to be replaced; milk having a lower butter fat content than the cream or milk to be replaced; and serum solids, such as skim milk powder. The composition has the beverage whitening ability of the cream or milk to be replaced in a target volume of from 30% to 95% of the volume of cream or milk to be replaced. The composition is formulated so that from 300 mL to 950 mL of the composition has the whitening ability of 1 liter of the cream or milk to be replaced. The composition is useful for replacing conventional coffee cream in dispensers containing bags of cream so as to reduce frequency of bag replacement.
US08420145B2 Isosorbide derivatives and their use as flavor modifiers, tastants, and taste enhancers
The present invention provides isosorbide derivatives having the formula shown below and certain subgenera or species thereof, as flavor or taste modifiers, particularly, savory (“umami”) taste modifiers, savory flavoring agents and savory flavor enhancers in foods, beverages, and other comestible compositions,
US08420142B2 Food and beverage preservative
Non-toxic, naturally derived, preservative compositions for beverage products, food products and other consumer products which include d-limonene, natural wax and monohydric alcohol are provided. Methods for manufacturing such preservative compositions are also provided. In addition beverage products, food products and other consumer products which include preservative compositions comprising d-limonene, natural wax and monohydric alcohol are provided.
US08420141B2 Prevention of synthetic color fading in beverages using botanically derived color stabilizers
Fading of synthetically colored beverages is prevented using botanically derived color stabilizers which are C6-C3 phenylpropenoic carbonyl compounds which contain both (i) unsaturation and (ii) oxidation at a carbon atom.
US08420140B2 Galvanic package for fruits and vegetables and preservation method
A package for fruits and vegetables having galvanic functionality is formed by using two or more metals with different galvanic activity properties on the surface of a nonmetallic substrate. The metals may be deposited electrolytically, by vacuum, autocatalytically, or by other methods. The metals are selected to create a galvanic reaction after the package is filled with a low pH food product and its associated liquids, juices, brine, etc. The package may extend the shelf-life of the food product contained therein, for example, by making metal ions available to the food product.
US08420139B2 Capsule for infusion beverages
The invention relates to a capsule and a device for preparing an infusion beverage, such as coffee, tea, or milk beverages. The capsule comprises two parallel extending wall sections, which are connected to each other by a sealing connection. A pressurized liquid or gaseous medium can be conducted through an access to the sealing connection of the capsule with the aid of a supply line in a holder of the device such that the sealing connection is partially undone. As a result, an opening is produced in the capsule. An infusion fluid can be conducted through the opening, wherein the fluid can then become mixed with a powder or granules present in the capsule into an infusion beverage. The infusion beverage can be discharged through a further opening.
US08420137B2 Bioactive composition for cosmetic applications
The invention relates to a process for the preparation of a plant extract from Curcuma plants, characterized by the process steps process step A) liquid extraction of Curcuma rhizomes, process step B) optionally, separation of a curcuminoid-containing solid obtained by precipitation from the extraction mixture obtained in process step A), process step C) removal of solvents present from the extraction mixture obtained in process step A) or B) to obtain a concentrate and process step D) distillation of the concentrate at a pressure of less than 1 bar to give the extract as distillate.
US08420136B2 Herbal preparation for anemia and a manufacture method thereof
A herbal extract for anemia is obtained by a process including steps of drying, by providing a herbal material comprising dry mulberry and dry Acanthopanax senticosus in a weight ratio of 2:1 to 1:2, with the water content of the herbal material lower than 10%; extracting, by soaking the herbal material into a solvent to obtain a liquid extract, with the weight ratio between the herbal material and the solvent being 1:10 to 1:5; and condensation, by condensing the liquid extract to obtain a herbal extract.
US08420134B2 Herbal medicinal composition and extract thereof for inhibiting growth of cancer cells
The present invention relates to herbal medicinal compositions and extracts thereof for inhibiting growth of cancer cells. One of the examples described in the present invention comprises Forsythiae fructus, Menthae Herba, Gardeniae Fructus, Scutellariae Radix, Lophatheri Folium, Glycyrrhizae Radix, Rhei Rhizoma, Na2SO4, and Atractylodis Rhizoma . The residual examples are described herein.
US08420133B2 Modified pectins, compositions and methods related thereto
The present invention provides compositions of modified pectin and methods for preparing and using them.
US08420122B2 Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same
The present invention provides a method of continuous precipitation and isolation of an amorphous solid particulate form of 3-[2-(3-tert-Butyl-ureido)-3,3-dimethyl-butyryl]-6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylic acid (2-carbamoyl-1-cyclobutylmethyl-2-oxo-ethyl)-amide having controlled physical properties. The present invention provides also pharmaceutical formulations comprising the precipitated compound.
US08420120B2 Oral drug delivery system
Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
US08420113B2 Biodegradable medical devices with enhanced mechanical strength and pharmacological functions
The present invention is directed to a medical device, specifically a prosthesis which utilizes a novel class of blends between biodegradable polymers and bioceramics for medical device applications allowing one to capitalize on the biodegradable nature of these two distinct materials while enhancing the strength of these devices through the addition of various amounts of bioactive ceramic and glasses to biodegradable polymers. The blend may be fabricated into a medical device such as a stent or a distal protection device, and may incorporate various agents to enhance radioapacity and/or pharmacological function. In addition, the blend may be used as a coating to a medical device.
US08420111B2 Method and kit for reducing the symptoms of peripheral vascular disease
A method for reducing the symptoms of peripheral vascular disease and for improving peripheral circulation wherein a progestin is administered to a subject in need thereof.
US08420107B2 Peptide vaccines against group A streptococci
This invention, in one aspect, relates to synthetic immunoreactive peptides. These peptides are approximately 20-25 amino acids in length which are portions of the N termini of the M proteins of the most prevalent United States (U.S.) Group A Streptococcus (GAS) serotypes. At least some of the synthetic peptides can be recognized by M type-specific antibodies and are capable of eliciting functional opsonic antibodies and/or anti-attachment antibodies without eliciting tissue cross-reactive antibodies. In another aspect, it relates to compositions or vaccines comprising these synthetic serotype-specific peptides, including polypeptides and proteins. The invention may also be isolated antibodies which are raised in response to the peptides, compositions or vaccines. The invention further relates to kits for using the peptides, compositions, or antibodies. In still further aspects, the invention also relates to methods for using the peptides, compositions, vaccines, or antibodies and methods for tailoring vaccines.
US08420105B2 Botulinum toxin administration to treat various conditions
Methods for treating conditions in an animal or human subject. The conditions may be pain, skeletal muscle conditions, smooth muscle conditions, glandular conditions and cosmetic conditions. The methods comprise the step of administering a Clostridium neurotoxin component or Clostridium neurotoxin component encoding DNA to the subject using a needleless syringe.
US08420100B2 Tumor suppressor activating polypeptides and uses thereof
Chimeric tumor suppressor activating peptides derived from matrix attachment region binding protein (MARBP) SMARI unique in their sequence comprising a arginine rich motif flanked by serine residues wherein from the stretch of four consecutive serine residues the first serine residue gets phosphorylated by the protein kinase C family of serine threonine kinases being indispensable for its functionality, the phosphorylation being directly correlated to the phosphorylation of p53 at serine 15 residue thereby stabilizing it, wherein the peptide activates p53 by modifying it post translationally which allow phosphorylation and translocation of p53 to the nucleus.
US08420096B2 Cell-penetrating SOCS polypeptides that inhibit cytokine-induced signaling
Disclosed are compositions and methods related to cell-penetrating suppressor of cytokine signaling (SOCS) proteins that inhibit cytokine-induced signaling.
US08420095B2 Antigen-containing microspheres for the treatment of allergies
Microspheres containing antigens for allergy therapy, the microspheres having a binding constant of 1×104 M−1 toward a specific carbohydrate residue of intestinal and/or nasal epithelial cells.
US08420093B2 Anti-ADDL monoclonal antibody and use thereof
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
US08420092B2 Method of treating diabetes by administering an anti-NKp46 antibody
The invention relates to use of the natural cytotoxicity receptor NKp46 for preventing and treating diabetes, including type I diabetes (TID) and type 2 diabetes. In particular, the invention provides compositions comprising a fragment of the extracellular region of NKp46 for preventing the onset and progression of diabetes.
US08420085B2 Anti-IGF-IR antibodies and uses thereof
The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor IGF-IR and/or capable of specifically inhibiting the tyrosine kinase activity of said IGF-IR, especially monoclonal antibodies of marine, chimeric and humanized origin, as well as the amino acid and nucleic acid sequences coding for these antibodies. The invention likewise comprises the use of these antibodies as a medicament for the prophylactic and/or therapeutic treatment of cancers overexpressing IGF-IR or any pathology connected with the overexpression of said receptor as well as in processes or kits for diagnosis of illnesses connected with the overexpression of the IGF-IR. The invention finally comprises products and/or compositions comprising such antibodies in combination with anti-EGFR antibodies and/or anti-VEGF antibodies and/or antibodies directed against other growth factors involved in tumor progression or metastasis and/or compounds and/or anti-cancer agents or agents conjugated with toxins and their use for the prevention and/or the treatment of certain cancers.
US08420074B2 Methods of making and using Lactobacillus strains
Lactobacillus strains that have a genetic Profile I based on Apa I, Not I, and Xba I digests are provided. Preferably, the strains decrease level of at least one of coliforms and E. coli within the gastrointestinal tract of an animal. A direct-fed microbial that includes the strain is additionally provided. A method of feeding an animal the strain and a method of forming a direct fed microbial that includes the strain is also provided.
US08420071B2 Herpes simplex virus expressing foreign genes and method for treating cancers therewith
An anti-cancer pharmaceutical composition includes a herpes simplex virus (HSV) vector into which a nucleic acid sequence encoding for an anti-cancer agent selected from interleukin-12, GM-CSF, and CD has been inserted. A method of treatment of a patient suffering from cancer includes administering to the patient the anti-tumor pharmaceutical composition including a HSV vector having a nucleic acid sequence encoding for an anti-cancer agent selected from interleukin-12, GM-CSF, and CD inserted therein.
US08420066B2 O/W emulsion cosmetic composition
Provided is an O/W emulsion cosmetic composition, which contains the following components (A), (B) and (C): (A) a polymer which is either a nonionic or cationic polymer composed of a hydrophobic monomer unit and a hydrophilic monomer unit and contains from 40 to 80 wt. % of a hydrophilic group; (B) a dispersion containing the following components (a), (b), (c) and (d): (a) powders having ultraviolet screening ability and having a surface subjected to hydrophobic treatment, (b) a polymer composed of a hydrophobic monomer unit and a hydrophilic monomer unit, (c) a silicone oil, and (d) an alcohol having from 1 to 3 carbon atoms, at an (a):(b):(c):(d) weight ratio of (from 25 to 65):(from 0.1 to 5):(from 10 to 50):(from 10 to 50); and (C) water.
US08420065B2 Hair or skin conditioning compositions comprising hydrophobically modified amido silicone copolyol
Disclosed are hair or skin conditioning compositions comprising by weight: (a) from about 0.1% to about 10% of a thickening polymer system; (b) from about 0.1% to about 8.0% of a surfactant system selected from the group consisting of cationic surfactant, nonionic surfactant, and mixtures thereof; (c) from about 0.1% to about 10% of a hydrophobically modified amido silicone copolyol; and (d) an aqueous carrier; wherein the composition has a transmittance of 25% or more and/or wherein the composition has a viscosity of from about 1,000 cps to about 50,000 cps and Shear Thinning Index of 30 or more. The compositions are especially suitable for hair care products such as hair conditioning products for rinse-off/leave-on use.
US08420063B2 Lip cosmetics
The present invention provides a lip cosmetic that has good gloss and good stability, while maintaining post-application secondary adhesion resistance. The lip cosmetic of the present invention is characterized by comprising the following components (a) to (d): (a) 4.5 to 35 mass % of glyceryl monoisostearate; (b) 20 to 80 mass % of one or more kinds of methyl phenyl silicones that do not separate out when mixed with (a) at 90° C. and separate out when mixed with (a) at 25° C.; (c) 5 mass % or more of water and/or glycerin, relative to the component (a), and 24 mass % or less, relative to the total amount of the cosmetic; and (d) 4 to 10 mass % of a wax.
US08420059B2 Aerosol composition
A single phase aerosol composition comprising the following constituents: (a) 5 to 75 wt % of a hydrofluorocarbon(s) (HFC) of vapor pressure greater than or equal to 4 bar at 20° C. (60 psig at 70° F.); (b) 10 to 30 wt % of a hydrocarbon propellant; (c) 1 to 70 wt % of a hydrocarbon solvent(s) with a vapor pressure of less than 0.1 mm Hg at 20° C.; (d) 0.01 to 10 wt % of an active constituent(s) selected from the group which includes fragrances, air-sanitisers, air fresheners, deodorizers, odor eliminators, malodor counteractants, insecticides, insect repellants, medicinal substances, disinfectants, aroma therapy compositions; and, (e) 0 to 25 wt % of an adjuvant constituent(s) other than (a), (b), (c) or (d). Methods of making the said composition and aerosol dispensers containing the said composition are also disclosed.
US08420051B2 Muteins of hNGAL and related proteins with affinity for a given target
The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also relates to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates a method for producing such a mutein. Furthermore, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.
US08420050B2 Gastrin releasing peptide compounds
Novel methods of treating prostate tumors or of delaying the progression of prostate tumors are also provided, including, methods of treating bone or soft tissue metastases of prostate cancer methods for treating hormone sensitive and hormone refractory prostate cancer, methods for delaying the progression of hormone sensitive prostate cancer, for facilitating combination therapy in patients with hormone sensitive prostate cancer and for decreasing aberrant vascular permeability in patients with hormone sensitive prostate cancer, said methods comprising the step of administering to a subject a dose comprising an amount of radioactively labeled L70, N-[4-[[[[[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]acetyl]amino]benzoyl]-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-leucyl-L-methioninamide.
US08420048B1 System and method for parallel solution extraction of one or more metal values from metal-bearing materials
The present disclosure relates to a process and system for recovery of one or more metal values using solution extraction techniques and to a system for metal value recovery. In an exemplary embodiment, the solution extraction system comprises a first solution extraction circuit and a second solution extraction circuit. A first metal-bearing solution is provided to the first and second circuit, and a second metal-bearing solution is provided to the first circuit. The first circuit produces a first rich electrolyte solution, which can be forwarded to primary metal value recovery, and a low-grade raffinate, which is forwarded to secondary metal value recovery. The second circuit produces a second rich electrolyte solution, which is also forwarded to primary metal value recovery. The first and second solution extraction circuits have independent organic phases and each circuit can operate independently of the other circuit.
US08420045B2 Use of redox mass having a spinel type structure for a looping redox process
The invention relates to the use of a novel type of active mass in looping redox processes. Said mass contains a spinel of formula Cu1−xFe1+xAlO4 with 0≦x≦0.1. The active mass according to the invention has a high oxygen transfer capacity and improved oxidation and reduction rates.
US08420041B2 High-pressure vessel for growing group III nitride crystals and method of growing group III nitride crystals using high-pressure vessel and group III nitride crystal
The present invention discloses a high-pressure vessel of large size formed with a limited size of e.g. Ni—Cr based precipitation hardenable superalloy. Vessel may have multiple zones. For instance, the high-pressure vessel may be divided into at least three regions with flow-restricting devices and the crystallization region is set higher temperature than other regions. This structure helps to reliably seal both ends of the high-pressure vessel, at the same time, may help to greatly reduce unfavorable precipitation of group III nitride at the bottom of the vessel. Invention also discloses novel procedures to grow crystals with improved purity, transparency and structural quality. Alkali metal-containing mineralizers are charged with minimum exposure to oxygen and moisture until the high-pressure vessel is filled with ammonia. Several methods to reduce oxygen contamination during the process steps are presented. Back etching of seed crystals and a new temperature ramping scheme to improve structural quality are disclosed.
US08420036B1 Control of NO/NO2 ratio to improve SCR efficiency for treating engine exhaust using bypass oxidation catalyst
Methods and systems for treating NOx-containing exhaust from an internal combustion engine. An exhaust aftertreatment system has at least a primary oxidation catalyst, a particulate filter, and a selective reduction catalyst (SCR). A bypass line diverts a portion of the exhaust from the exhaust line from a point downstream the particulate filter to a point upstream the SCR. A secondary oxidation catalyst on the bypass line is used to generate NO or NO2 to be returned to the exhaust line upstream the SCR.
US08420033B2 Compositions and methods to sequester flue gas mercury in concrete
Mercury adsorbed from combustion gas by activated carbon can be sequestered in concrete containing air entraining admixtures. The activated carbon may be made by providing a carbon char made from anthracite or low-volatile bituminous coal that was devolatilized and carbonized in an oxygen-depleted environment and activating this char in the presence of steam to provide an activated carbon with an acid blue 80 index of less than about 30 milligrams per gram of carbon. The activated carbon may also be made by providing a carbon char that was devolatilized and carbonized in an oxygen-depleted environment and activating this char in the presence of oxygen to provide an activated carbon. The carbon may be injected into a combustion gas stream containing fly ash and mercury and may then be removed with fly ash from the gas stream. The resulting composition may be used as a partial substitute for cement in air-entrained concretes.
US08420030B2 Well plate for holding a sample during analysis and a method for preparing a sample for analysis
A well plate (1) for holding samples of a bodily fluid during analysis thereof, typically in an analytical apparatus, comprises a plate (2) having a plurality of first wells (3) extending downwardly therefrom for holding a sample during optical analysis of the sample, and a plurality of second wells (4) for holding samples during mechanical analysis of the samples. A plurality of holding wells (8) are provided for initially receiving and holding samples of the bodily fluid to be analysed so that samples of relatively accurate size can be pipetted from the holding wells (8) to the first and second wells (3,4).
US08420029B2 Clean transportation system
A transportation system for transporting a biological material container between a sterile field and a nonsterile field and substantially maintaining sterility of the biological material container includes a housing assembly that removably houses the biological material container. The system also includes a port defined by the housing assembly, and the port provides communication into the biological material container from outside the housing assembly. The housing assembly includes a first member that covers a first portion of the biological material container such that a second portion of the biological material container extends from the first member. The housing assembly also includes a second member that covers the second portion of the biological material container. The second member is removably coupled to the first member to expose the second portion of the biological material container. A keying member that keys the transportation system in a centrifuge is also disclosed.
US08420020B2 Honeycomb filter and method for manufacturing honeycomb filter
A honeycomb filter includes a plurality of porous partition portions each forming a cell, which is open at one end and closed at the other end and serves as an exhaust gas flow path, and a trapping layer, for trapping and removing solid components contained in the exhaust gas, formed on each of the partition portions. At least part of each of the partition portions is loaded with a catalyst. The amount of catalyst a (g/L) in an upstream partition portion and the amount of catalyst b (g/L) in a downstream partition portion satisfy 1.05≦a/b≦3.00. A method for limiting a/b to this range includes the entire honeycomb structure, including the partition portions, into contact with a catalyst component to form a catalyst, and subsequently bringing only an upstream region of the honeycomb structure into contact with a catalyst component to form a catalyst.
US08420016B2 Microbial deactivation apparatus having integrated ultrasonic drying system
A system for microbially deactivating articles, such as medical, dental, veterinary and mortuary instruments and devices. The system includes vibration means for producing ultrasonic waves to facilitate drying after the completion of a liquid microbial deactivation process.
US08420012B2 Use of monochlorourea to treat industrial waters
The present invention comprises a method for controlling (e.g. inhibiting) or killing microorganisms in an aqueous environment. The method includes the addition of an effective amount of monochlorourea or modified monochlorourea to an aqueous solution. This aqueous solution may be a cooling water system, a recreational water system, a water treatment facility, or any circulating water system (i.e. a papermaking facility). A method of producing monochlorourea or modified monochlorourea is also disclosed.
US08420011B2 Aluminum alloy plate and process for producing the same
The present invention provides an Al—Mg series alloy sheet of high-Mg with improved press formability and homogeneity which can be applied to automobile outer panels and inner panels. This is an Al—Mg series aluminum alloy sheet having 0.5 to 3 mm in thickness cast by twin-roll continuous casting and cold rolled, comprising over 8% but not more than 14% Mg, 1.0% or less Fe, and 0.5% or less Si with the remainder being Al and unavoidable impurities wherein the mean conductivity of the aluminum alloy sheet is in the range of at least 20 IACS % but less than 26 IACS %, the strength-ductility balance (tensile strength×total elongation) as a material property of the aluminum alloy sheet is 11000 (MPa %) or more, and the homogeneity and press formability of the sheet have been improved.
US08420007B2 Apparatus for direct smelting of zinc bearing compounds to produce metallic zinc
Apparatus for producing lead and zinc from concentrates of zinc and lead sulfides or oxides, including: a source of zinc ore and/or lead ore concentrates, iron bearing and carbon containing materials; metallic iron fines and iron oxide fines; carbonaceous reductant; fluxing agent; and a binder; a mixer for forming a mixture from said concentrates and other materials; an agglomerator communicating with the mixer for forming agglomerates from the mixture; a melting furnace for melting the mixture and vaporizing lead and zinc; a pressure sealed feed system communicating with the agglomerator and the melting furnace for introducing agglomerates to the melting furnace; a pressure sealed chamber surrounding the melting furnace; a water-cooled condenser for receiving the vaporized metal and cooling and condensing the metal vapors to liquid metal; a tapping device communicating with the condenser for removing the liquid metal; and associated devices for separating the zinc and lead and recovering the lead and zinc metal separately.
US08420003B2 Method of manufacturing a belt member and the belt member
A tube material is formed by continuously extruding a thermoplastic resin material in the shape of a cylinder that has a thickness of 100 μm and a circumferential length of 800 mm. After that, in a polishing process, the tube material is rubbed with a lapping tape of #2000 while being rotated in one direction at a fixed speed, so that circumferential stripes are formed on the outer circumferential surface of the tube material. Then, the circumferential stripes are thermally transferred by pressing the outer circumferential surface of the heated tube material against a mold surface that is finished in the shape of circumferential stripes by a thermal transfer process.
US08420002B2 Method of RTM molding
A method of RTM molding wherein a reinforcing fiber substrate is placed in a mold, each of a first and a second resin distribution media exhibiting a resin flow resistance lower than the resistance of the reinforcing fiber substrate is placed on each surface of the reinforcing fiber substrate, and the inside of the mold is evacuated and a resin is injected into the mold to thereby impregnate the reinforcing fiber substrate with the resin injected, characterized in that the first resin distribution medium exhibits a resin flow resistance lower than that of the second resin distribution medium, and the evacuation is carried out through the second resin distribution medium while the resin is injected through the first resin distribution medium. The method can be advantageously employed for producing, in particular, FRP structure which is thick and excellent in designability, lightweight property and/or strength.
US08419997B2 Method and device for injection molding plastic material
The present invention relates to a method and to a device for injection molding plastic material, wherein the starting plastic material to be treated is first subjected to a pretreatment, wherein the plastic material is heated in a receiving container at a temperature below the melting temperature while constantly being mixed, and thereby at the same time is crystallized, dried and/or cleaned and/or the intrinsic viscosity thereof is increased. According to the invention, the plastic material pretreated in this way is transferred into a screw injection molding machine (10) having a screw (16) rotating in a housing (17) and being axially displaceable therein and/or acting as a piston, is plasticized in said screw, and molded into a molded part, for example a preform.
US08419993B2 Extrusion blow molding machine and method for the production of a hollow plastic body
The invention relates to an extrusion blow molding machine (1) with at least one extrusion head (2) and with at least two sheet dies (3), arranged next to one another, for the extrusion of sheet-like plastic preforms (4), with a multipart molding die (5) for processing two preforms into an essentially closed hollow body, having a device for handling the preforms (4). The device for handling the preforms comprises at least two grippers (10), arranged next to one another on a common carrier (8), for receiving the preforms (4), the distance between the grippers (10) being variable.
US08419992B2 Mold for gasket, method for manufacturing the gasket, and gasket
This invention provides a mold for a gasket, which can render the planar shape of a mold for integral molding of a large-diameter gasket as small as possible to reduce the size of the manufacturing equipment and, at the same time, by virtue of integral molding, does not require labor and time in the manufacture thereof and does not cause a lack of strength in the connecting part. To this end, a mold (1) for molding an endless-type gasket comprises a plurality of molding parts (11,21), formed by disposing two molding grooves (12, 22), in a spiral wound form, in parallel so as to be adjacent to each other. The spiral wound molding grooves (12, 22) have reversing parts (14, 24) in their respective inner ends (13, 23), and, at the same time, their outer ends (15, 25) are connected to each other in a rope form.
US08419980B2 Ternary thermoelectric material containing nanoparticles and process for producing the same
A thermoelectric material that comprises a ternary main group matrix material and nano-particles and/or nano-inclusions of a Group 2 or Group 12 metal oxide dispersed therein. A process for making the thermoelectric material that includes reacting a reduced metal precursor with an oxidized metal precursor in the presence of nanoparticles.
US08419977B2 Conductive coating, method for preparing a coating, roller, and method for manufacturing a roller and using a coating
A conductive coating is described, suitable for coating a developer, charge or transfer roller in a developing apparatus to give a charge providing layer. The coating comprises a conductive polymer in a matrix. A roller is also described, suitable for a developing apparatus comprising, from the center to the periphery, a conductive mandrel, a conductive elastic base layer and a charge providing layer.
US08419976B2 Polyelectrolyte complexes as thickeners for high ionic strength salt solutions
A polyelectrolyte complex composition capable of viscosifying or thickening an aqueous high salt-containing system comprises a mixture of at least one anionic polymer and at least one cationic polymer in an inorganic salt-containing aqueous medium. The anionic polymer and cationic polymer can each be linear and water-soluble, crosslinked and water-soluble, or crosslinked and water-insoluble or swellable.
US08419973B2 Polymerizable liquid crystal composition and homeotropically-aligned liquid crystal film
A polymerizable liquid crystal composition is provided that can contains a mixture of polymerizable compounds containing a compound represented by the formula (1-1), a compound represented by the formula (2), a compound represented by the formula (3-1) and a compound represented by the formula (4), and a amine silane coupling agent. The composition can form a polymerizable liquid crystal layer exhibiting a uniform homeotropic alignment by coating the composition on a supporting substrate, independently from the kind of the supporting substrate without a special alignment film. Examples of each of the components are shown below, in which ring T represents triptycen-1,4-diyl.
US08419971B2 Method for producing mechanically stable water-absorbent polymer particles
A process for producing water-absorbing polymer particles by polymerizing droplets of a monomer solution in a gas phase surrounding the droplets, wherein the particle surface is coated at least partly with at least one polymer and/or wax.
US08419970B2 Silicon nitride polishing liquid and polishing method
A silicon nitride polishing liquid for chemical mechanical polishing of a body to be polished in a planarization process for manufacturing of a semiconductor integrated circuit, the body to be polished including at least a first layer containing silicon nitride and a second layer containing at least one silicon-including material selected from the group consisting of polysilicon, modified polysilicon, silicon oxide, silicon carbide, and silicon oxycarbide, the silicon nitride polishing liquid having a pH of 2.5 to 5.0, and including (a) colloidal silica, (b) an organic acid that has at least one sulfonic acid group or phosphonic acid group in the molecular structure thereof and functions as a polishing accelerator for silicon nitride, and (c) water.
US08419968B2 Lubricants for refrigeration systems
A polyol ester suitable for use as a lubricant or a lubricant base stock has a kinematic viscosity at 40° C. less than or equal to 22 cSt and a viscosity index of greater than or equal to 140. The ester comprises a reaction product of (a) at least one polyhydric alcohol having at least 2 primary hydroxyl groups, (b) at least one monocarboxylic acid having 2 to 15 carbon atoms and (c) at least one polycarboxylic acid having 2 to 15 carbon atoms, wherein the number of acid groups derived from the polycarboxylic acid(s) is at least 25% of the total number of acid groups derived from the monocarboxylic and polycarboxylic acids.
US08419961B2 Oil/gas separation membrane, its use in gas sensor and process for producing the same
An oil gas separation membrane combines a gas permeable yet oil and temperature resistant bulk polymer membrane such as poly(tetrafluoroethylene) and poly(tetrafluoroethylene-co-hexafluoropropylene); a porous metal support such as sintered metal frit disk made with stainless steel, bronze or nickel; and an highly gas permeable adhesive that bonds firmly the bulk polymer membrane and the metal frit surface together. The adhesive is either a homogenous polymer that has desirable gas permeability, or a coalescent porous polymer particulates network. A gas sensor employing the oil gas separation membrane for detecting and monitoring fault gases of oil filled electrical equipment requires no mechanical wearing or moving part such as pump and valve and the gas sensor is operated normally under various temperature and pressure conditions.
US08419959B2 Clamped monolithic showerhead electrode
An electrode assembly for a plasma reaction chamber used in semiconductor substrate processing. The assembly includes an upper showerhead electrode which is mechanically attached to a backing plate by a series of spaced apart cam locks. A guard ring surrounds the backing plate and is movable to positions at which openings in the guard ring align with openings in the backing plate so that the cam locks can be rotated with a tool to release locking pins extending from the upper face of the showerhead electrode.
US08419954B1 Method for providing a side shield for a magnetic recording transducer
A method for fabricating a side shield for a magnetic transducer is described. The transducer has a nonmagnetic layer, a pole, a gap layer between the pole sidewalls and the nonmagnetic layer, and a hard mask having a hard mask aperture. A removal mask having a removal aperture exposing part of the pole and hard mask aperture is provided. The removal mask covers part of the hard mask aperture and the part of the hard mask. A trench in the nonmagnetic layer is formed by removing part of the nonmagnetic layer. A seed layer is deposited. A deposition mask having a deposition aperture therein is provided. The deposition aperture exposes part of the trench and part of the nonmagnetic layer. Side shield material(s) are deposited. Part of the side shield material(s) external to the deposition trench are removed. A remaining portion of the side shield material forms the side shield.
US08419952B2 Method of manufacturing magnetic recording medium and magnetic recording apparatus
According to one embodiment, a method of manufacturing a patterned medium includes forming an implantation depth-adjusting layer above a magnetic recording layer, the magnetic recording layer being made of a material that is deactivated when implanted with a chemical species, and the implantation depth-adjusting layer being made of a material that is etched when irradiated with an ion beam of the chemical species and irradiating the implantation depth-adjusting layer with the ion beam to implant the chemical species into a part of the magnetic recording layer through the implantation depth-adjusting layer while etching the implantation depth-adjusting layer by an action of the ion beam to decrease a thickness of the implantation depth-adjusting layer.
US08419951B2 Method of manufacturing magnetic recording medium, and magnetic recording/reproducing device
A method of manufacturing a magnetic recording medium is provided, which include: forming a magnetic layer on the surface of a nonmagnetic substrate; forming a groove in which a nonmagnetic section is formed by etching a portion corresponding to a formation region of the nonmagnetic section in the magnetic layer and a magnetic recording section formed of the magnetic layer; applying a resin having an active energy ray curable functional group to the surface of the magnetic recording section so as to fill the groove; pressing a plate material against the resin so that the smooth surface of the plate material is in contact with the surface of the resin to make the surface of the resin smooth; removing the plate material from the resin; and forming the nonmagnetic section in the groove by etching and removing a portion located above the surface of the magnetic recording section in the resin having a smooth surface.
US08419950B2 Pattern forming method
According to one embodiment, a pattern forming method is disclosed. The method includes contacting a template with light curable resin on a substrate. The template comprises a concave-convex pattern including concave portions and convex portions, and a metal layer provided on a convex portion of the concave-convex pattern. The concave-convex pattern is to be contacted with the light curable resin. The pattern forming method further includes irradiating the light curable resin with light of a predetermined wavelength under a condition ε1=−2ε2. Where ε1 is a complex relative permittivity of the metal layer corresponding to the predetermined wavelength, ε2 is a complex relative permittivity of the light curable resin corresponding to the predetermined wavelength.
US08419940B2 Combined axial piston liquid pump and energy recovery pressure exchanger
A pumping machine, that can serve a system as the sole main pump for pressurizing a primary liquid flow, incorporates, in a single machine, a rotor-drum type AP (axial piston) pump and a PX (pressure exchanger) that recovers energy from a secondary liquid flow such as the brine discharge from an RO seawater desalination system, with benefits including fewer moving parts and small machine size along with lower capital and operating costs. A single rotor-drum containing the cylinders and pistons is located between two end blocks, one or both configured with manifold passageways, ports and sliding valves. A swash-plate at one end reciprocates the pistons axially when the rotor-drum is rotated. Two working chambers, primary and secondary, are formed at opposite ends of a single piston in each cylinder, thus enabling the single rotor-drum to function as a primary liquid-pressurizing axial pump (AP) with sliding valves at the primary end enabling primary liquid pumping, and as a secondary outflow-driven pressure exchanger (PX) recovering energy from pressure drop in the secondary liquid flow and thus contributing work to primary pumping, saving energy and reducing operating costs.
US08419939B2 Micro dialyzer
A spherical dialysis chamber with a heavier cap (the density of cap material is higher than that of the dialyzer) or the distribution of weight is such that it is higher weight distribution is towards the cap, so that it tilts always towards the bottom of the container containing the dialysis buffer.
US08419932B2 Method and apparatus for separating cooking oils from snack food products through a quasi-continuous centrifuge action
A centrifuge operative in successive low speed and high speed modes serves to remove surface cooking oil from a continuous stream of fragile snack food products wherein the oil removal occurs in the high speed mode and products are discharged from the centrifuge with relatively low kinetic energy in the low speed mode.
US08419930B2 System for preparing high-quality gasoline through component oil refining hydrocarbon recombination hydrogenation and method thereof
The invention discloses a system for preparing high-quality gasoline through component oil refining hydrocarbon recombination hydrogenation and a method thereof, which is characterized by comprising an extraction system, a distillation system and a hydrogenation device, wherein the upper part of the extraction system is connected with the distillation system through a pipeline, and the lower part of the extraction system is connected with an extract oil hydrogenation device through the pipeline; light gasoline is recovered by the upper part of the distillation system through the pipeline; the lower part of the distillation system is connected with the heavy gasoline hydrogenation device through the pipeline; and reformate or ethylene feed are recovered through the lower part of the heavy gasoline hydrogenation device through the pipeline. The system for preparing high-quality gasoline through component oil refining hydrocarbon recombination hydrogenation and the method thereof has small scale and low cost and can remove olefin, mercaptan sulphur and diene.
US08419926B2 Electrolyzed water producing method and apparatus
Electrolyzed water producing method and apparatus are provided which are capable of producing electrolyzed water having a desired property irrespective of the quality of raw water supplied and the like while allowing the size and weight of the apparatus and the cost to be reduced by limiting the capacity of an electrolysis power source. The electrolyzed water producing method includes: circulating an aqueous electrolyte solution to a first electrolytic chamber of a pair of electrolytic chambers opposed to each other across an intervening ion permeable diaphragm while supplying raw water to the second electrolytic chamber; and applying a predetermined voltage to a pair of electrodes disposed in the respective electrolytic chambers with the diaphragm intervening there between, to electrolyze the raw water and the aqueous electrolyte solution, thereby producing electrolyzed water in the second electrolytic chamber.
US08419923B2 Lithographic printing plate support
A method for making a lithographic printing plate support is disclosed comprising the steps of: (i) providing an aluminum support; (ii) treating said support in an aqueous solution; (iii) graining said treated support in an electrolyte solution by applying an alternating voltage thereby inducing a local current density J; characterized in that said local current density J at time t fulfills the following equation: J(t)≦a+bQ(t) for t=o to t=tf and wherein Q(t) is the integrated value of the absolute value of the local current density at time t:(I)—a is equal to 5—b is equal to 10—and tf is the time necessary to obtain a value of Q(t) equal to 50 C/dm2. Q ⁡ ( t ) = ∫ 0 t ⁢  J ⁡ ( τ )  ⁢ ⅆ τ
US08419922B2 Efficient production of hydrogen
A liquid phase process for producing hydrogen gas in a reactor comprising the step of combining at least one oxidizable reactant with liquid water and at least one alkaline electrolyte to form a mixture having a pH, wherein the pH of the mixture is substantially maintained at a value of about 10.5 or greater and conducting a reaction in the presence of an electron transfer material that permits the movement of electrons. An alternative method produces hydrogen gas from a reaction in an electrochemical cell, the reaction characterized by an overall thermodynamic energy balance and half-cell reactions occurring at each of an anode and cathode. Energy transfers, such as thermal and electric, are analyzed and controlled in order to satisfy the thermodynamic energy balance of the reaction for efficient hydrogen production.
US08419921B2 Electrolytic apparatus for producing fluorine or nitrogen trifluoride
It is a task of the present invention to provide an electrolytic apparatus for producing fluorine or nitrogen trifluoride by electrolyzing a hydrogen fluoride-containing molten salt, the electrolytic apparatus being advantageous in that the electrolysis can be performed without the occurrence of the anode effect even at a high current density and without the occurrence of an anodic dissolution. In the present invention, this task has been accomplished by an electrolytic apparatus for producing fluorine or nitrogen trifluoride by electrolyzing a hydrogen fluoride-containing molten salt at an applied current density of from 1 to 1,000 A/dm2, the electrolytic apparatus using a conductive diamond-coated electrode as an anode.
US08419920B2 Method of preparing electrolytic copper solution acidified with sulfuric acid, sulfuric-acid-acidified electrolytic copper solution prepared by the preparation method, and electrodeposited copper film
An object of the present invention is to provide a method for preparing a sulfuric acid base copper electrolytic solution used for formation of an electro-deposited copper film comprising a surface excellent in smoothness and gloss when formed by using the solution just after preparation and is prepared by using mono-sulfides. To achieve the object, a sulfuric acid base copper electrolytic solution is made to contain a sulfonated active sulfur compound, the bis(3-sulfopropyl)disulfide which is recommended for formation of a glossy electro-deposited copper film. And the bis(3-sulfopropyl)disulfide contained is obtained by converting a 3-mercapto-1-propanesulfonic acid into the bis(3-sulfopropyl)disulfide in an aqueous solution of the 3-mercapto-1-propanesulfonic acid by an oxidation reaction. In the oxidation reaction, an air bubbling method is preferably used to prevent oxidative decomposition of the 3-mercapto-1-propanesulfonic acid.
US08419919B1 System and method for generating particles
A method may include the steps of supplying current to the electrodes of an electrochemical cell according to a first charging profile, wherein the electrochemical cell has an anode, cathode, and electrolytic solution; maintaining a generally constant current between the electrodes; exposing the cell to an external field either during or after the termination of the deposition of deuterium absorbing metal on the cathode; and supplying current to the electrodes according to a second charging profile during the exposure of the cell to the external field. The electrolytic solution may include a metallic salt including palladium, and a supporting electrolyte, each dissolved in heavy water. The cathode may comprise a second metal that does not substantially absorb deuterium, such as gold. The external field may be a magnetic field.
US08419917B2 Electroplating head and method for operating the same
An electroplating head is disposed above and proximate to an upper surface of a wafer. Cations are transferred from an anode to an electroplating solution within the electroplating head. The electroplating solution flows downward through a porous electrically resistive material at an exit of the electroplating head to be disposed on the upper surface of the wafer. An electric current is established between the anode and the upper surface of the wafer through the electroplating solution. The electric current is uniformly distributed by the porous electrically resistive material present between the anode and the upper surface of the wafer. The electric current causes the cations to be attracted to the upper surface of the wafer.
US08419913B2 Porous electroconductive material and process for production thereof; electrode and process for production thereof; fuel cell and process for production thereof; and electronic instrument, mobile machine, electric power generating system, cogeneration system, and electrode reaction-based apparatus
A porous electroconductive material is provided. The electroconductive material enables efficient enzymatic metabolic reactions on electrodes and yields electrodes having immobilized enzymes thereon which remain stable in any working environment. The porous electroconductive material, which has a three-dimensional network structure, is formed from a skeleton of porous material and a carbonaceous material covering the surface of the skeleton. The porous material constituting the skeleton is foamed metal or alloy. This porous electroconductive material is made into an electrode, and enzymes are immobilized on this electrode. The resulting electrode with immobilized enzymes thereon is used as the anode of a bio-fuel cell.
US08419904B2 Systems and methods for solar water purification
Systems and methods for solar water purification are described. In one exemplary aspect, the system includes a sun-tracking reflecting mirror unit, and a two-axis Fresnel concentrator mirror unit to collect sunlight reflected from the sun-tracking reflecting mirror unit and focus the sunlight. A central water purification boiler module includes a heating zone upon which the sunlight is focused by the two-axis Fresnel concentrator mirror unit. The focused sunlight heats the water contained therein to create steam which is redirected to heat water coming into the boiler and to condense as purified water.
US08419900B2 Apparatus for pretreatment for saccharification of lignocellulose biomass
To provide an apparatus for pretreatment for saccharification easily and continuously applying a treatment and capable of reusing ammonia at low cost. The apparatus has a mixing unit 2, a first heating unit 3, a separation unit 4, a transfer unit 6, an ammonia water supply unit 8 and an ammonia recovery unit 19. The apparatus may have the first heat exchanger 18, a second heat exchanger 25 and a heat supply unit 27 and further has a second heating unit 14. The apparatus may have a wet grinding unit 32 between the heating unit 3 and 25.
US08419899B2 Paperboard containing recycled fibers and method of making the same
A paperboard comprises from greater than 0% to 100% recycled fibers and has a microorganism count of less than 5,000 colony forming units per gram of paperboard.
US08419896B2 Semi-automated reworkability process for de-bonding a display
A method for reworking a bonded display (e.g., a bonded LCD) having a substrate (e.g., plate or film) adhesively bonded to a face (e.g., front face) of the display. The method provides for efficient and clean removal of the substrate from the bonded display when necessary (e.g., when defect(s) are present) to afford a de-bonded display that is undamaged such that the resulting de-bonded display (e.g., de-bonded LCD) can subsequently be re-bonded as a component in a device being manufactured.
US08419893B2 Shielded lid heater assembly
A shielded lid heater lid heater suitable for use with a plasma processing chamber, a plasma processing chamber having a shielded lid heater and a method for plasma processing are provided. The method and apparatus enhances positional control of plasma location within a plasma processing chamber, and may be utilized in etch, deposition, implant, and thermal processing systems, among other applications where the control of plasma location is desirable. In one embodiment, a shielded lid heater is provided that includes an aluminum base and RF shield sandwiching a heater element.
US08419892B2 Plasma process detecting sensor
The present invention provides a plasma process detecting sensor. In the plasma process detecting sensor, a hole diameter of an insulating film is spread with almost no spread of a hole diameter of an upper electrode. Therefore, when the plasma process detecting sensor is exposed to a plasma, positive ions incident onto the bottom of a contact hole are hard to collide with an inner wall surface of a hole main body of the insulating film. As a result, the inner wall surface of the hole main body of the insulating film is hard to undergo damage, and the generation of a defect level that assists electric conduction can be suppressed. It is thus possible to suppress age deterioration of a sensor function during the measurement of a charge-up under an environment of a plasma etching condition.
US08419890B2 Composition for structural adhesive
The invention relates to composition for an acrylic structural adhesive containing a mixture of block copolymers containing styrene and an elastomer.
US08419889B2 Ultrasecure card package
A package for securing a card is disclosed where the card is retained between two panels that are secured together by a heat-activated adhesives and/or a combination of polymeric and adhesive constituents to drastically hinder surreptitious access to the contents of the package. The package may include additional features for activating or accessing the card and increasing the aesthetic appeal of the package.
US08419887B2 Composite structural member and method for producing the same
A composite structural member is provided. The structural member includes a tubular shaft having a mating region of stiffness, and possibly thickness, greater than another region of said shaft. The shaft defines a lumen, and a fitting is disposed in the lumen. The fitting has a coupling region that defines at least one recessed portion bounded by one or more non-recessed portions, and the mating region mates with the coupling region of said fitting. As such, the shaft and fitting are mechanically restrained from at least some relative movement due to interference of the shaft and the fitting. A sleeve may be coupled to said shaft, for example, by including a tubular inner surface that proximately surrounds at least part of said shaft and mating region, for discouraging expansion of the mating region of said shaft.
US08419884B2 Method for manufacturing multilayer wiring substrate
A method for manufacturing a multilayer wiring substrate processes a via hole without unnecessarily increasing the diameter thereof and which can easily achieve the formation of fine wiring. A first resin layer in a cured state is prepared in which at least one first via hole including a bottom made of a conductive pattern is formed by laser processing, a second resin layer in an uncured state is prepared in which at least one second via hole is formed to penetrate therethrough at a position corresponding to the first via hole, and the first resin layer and the second resin layer are laminated to each other so that the first via hole and the second via hole communicate with each other. After a conductive paste is simultaneously filled in the first via hole and the second via hole, a metal foil is pressure-bonded to the second resin layer, and the second resin layer and the conductive paste are simultaneously cured. Subsequently, the metal foil is patterned.
US08419880B2 Method of transferring graphene
A method of transferring graphene, the method including: preparing a graphene forming structure including a base member, an oxide layer that is hydrophilic and is formed on the base member, a metal catalyst layer that is hydrophobic and is formed on the oxide layer, and graphene that is formed on the metal catalyst layer; attaching the graphene forming structure on a surface of a first carrier; separating the oxide layer from the metal catalyst layer by applying steam to the graphene forming structure; and removing the metal catalyst layer.
US08419874B2 Method for making diaper
A method of making a diaper includes: forming the continuous sheet at a distance in a width direction from an imaginary center line M bisecting the width dimension of the continuous sheet with let-through openings for passage of feces at a regular pitch, bonding absorbent panels, each having an absorbent core to the middle section of a sheet piece having an area larger than the area of the absorbent core; coating the surface of the continuous sheet opposite to the surface to which the absorbent panels have been bonded with hot melt adhesive HM; and cutting the assembly of the continuous sheet and the absorbent panels along the imaginary vertical line V defined between each pair of the adjacent absorbent panels at the regular pitch to obtain the diapers.
US08419872B2 Asphalt-based reactive polyurethane roof membrane adhesive
A cold applied adhesive that includes a blend of polyurethane pre-polymer, petroleum liquid and additive. The weight percent of petroleum liquid in the blend is less than 50 weight percent. The weight percent of polyurethane pre-polymer in the blend is less than 50 weight percent.
US08419870B2 Method for making strain aging resistant steel
A method for making a strain aging resistant steel comprises adding boron to the steel, wherein substantially all of the boron in the steel forms boron nitride. A method for making steel comprises adding a nitride-forming element to the steel to lower the free nitrogen content of the steel to a free nitrogen content specification. A high-carbon steel contains boron nitride, wherein the free nitrogen content of the steel is less than 80 ppm. A strain aging resistant steel wherein the carbon content of the steel is between about 0.54 percent and about 0.75 percent.
US08419867B2 Gold alloy compositions formed by environmentally friendly process
Rose-color and yellow-color gold alloys are formed from a gold-base alloy containing silver and copper. Mining these elements is usually highly detrimental to the environmental. Environmentally friendly alloys are obtained through the use of recycled elements and elements recovered from mines utilizing specific guidelines. Jewelry manufactured from these environmentally friendly alloys may be more receptive to a consumer, resulting in a competitive advantage.
US08419866B2 Method of manufacturing transition metal oxide having spinel structure
A novel method of manufacturing a transition metal oxide having a spinel structure is provided. A mixture of powdery metals of metal elements constituting the transition metal oxide is heated in an oxidizing atmosphere to generate the transition metal oxide.
US08419865B2 Heat recovery system for use with a washing appliance
A heat recovery system for use with a washing appliance having a tub includes a heat exchanger having a first tube and a second tube extending through the first tube such that the first tube and the second tube are substantially concentric. A first end connector is configured to couple to a first end portion of the first tube and a first end portion of the second tube. The first end connector is formed as one-piece and includes a first connection portion configured to couple in flow communication with the first tube, and a second connection portion configured to couple in flow communication with the second tube.
US08419864B2 Dishwasher
A dishwasher includes a wash compartment with a retainer, a water connector supported by the retainer and that connects a supply line from a water supply network to a liquid line system of the dishwasher.
US08419861B2 Method for adapting a rinsing program in a dishwasher machine, and corresponding dishwasher machine
A method for adapting a rinsing program in a dishwasher machine, and a dishwashing machine configured to perform the method, the method enabling the rinsing program run of a dishwasher machine to be adapted in such a way that satisfactory cleaning and drying performances are achieved even when using a combination rinse aid. To this end, the rinsing program run is adapted if there is insufficient salt, if the softening device is switched off, and if the dishwasher machine is on.
US08419860B2 Device and method of sensing temperature of a rotating electromagnetic machine
A system and method of determining the temperature of a rotating electromagnetic machine, such as an electric motor or generator. A temperature calibration parameter is calculated based on the temperature of an object situated close to the motor, such as a motor drive connected to the motor, and a first resistance value of the winding. In exemplary embodiments, the motor drive and first resistance value are determined only after the motor has been idle for some predetermined time period. Once the calibration parameter is calculated, the processor uses it along with subsequent resistance measurements to calculate the temperature of the motor.
US08419859B2 Method of cleaning plasma-treating apparatus, plasma-treating apparatus where the cleaning method is practiced, and memory medium memorizing program executing the cleaning method
A method of cleaning a plasma processing apparatus for processing a target in a process container, which is vacuum-evacuatable, using plasma, includes performing a first cleaning process by supplying a cleaning gas into the process container to generate plasma and maintaining the pressure in the process container at a first pressure, and performing a second cleaning process by supplying a cleaning gas into the process container to generate plasma and maintaining the pressure in the process container at a second pressure that is higher than the first pressure. Accordingly, the plasma processing apparatus can be efficiently and rapidly cleaned without damaging at least one of the group consisting of inner surfaces of the process container and members in the process container.
US08419851B2 Sulfate resistant cement
Mixed cement containing mainly ground granulated blast furnace slag with an alumina ratio of 12 to 17.5 mass % and Portland cement, wherein a ratio of mixture of the ground granulated blast furnace slag is made 10 to 60 mass % and wherein plaster having a specific surface area of 7000 cm2/g or more is mixed in by a ratio of 2 to 4 mass % converted to SO3 mass. By using this mixed cement as a concrete material, it is possible to suppress expansion of the concrete even if in contact with soil containing residual sulfates over a long period.
US08419850B2 Aqueous composition containing a carbonate of zirconium and of an alkaline metal salt, and an ammonium halide, as well as its use thereof
The invention relates to an aqueous composition comprising a carbonate of zirconium and of an alkali metal salt, prepared from a zirconium compound and an alkali metal bicarbonate, and an ammonium halide, and to its use as insolubilizing agent in a coating bath for paper or board.
US08419845B2 Air filter
The present invention provides an air filter including a main body, a pressure fan, a filter mode and a fixing assembly. The main body has a containing room, an entrance hole and an exit hole. The pressure fan is disposed in the containing room. The filter mode includes a first filter layer, a second filter layer and a frame body. The first filter layer is disposed in the entrance hole, and the second filter layer is disposed in the frame body. As such, users can select to use only the first filter layer or both filter layers at one time. Moreover, users only need to let the frame body pivot to a position away from the entrance hole so that users can change the filter layers faster and easier.
US08419840B2 Air-conditioning system
The present invention provides an air-conditioning system that supplies a gas to a space to be air-conditioned and/or discharges a gas from the space to be air-conditioned through a permeable membrane in order to provide an air-conditioning system that can sufficiently block suspended matter in the air such as SPM, and can sufficiently introduce outside air in which the permeable membrane is an asymmetric membrane formed of a polymeric material prepared by polymerizing a monomer composition containing a predetermined monomer.
US08419834B2 Air cleaner assembly
In at least some embodiments, the present invention relates to an air cleaner having a housing portion, and a low profile rain cover having an opening on an underside of the cover to allow unfiltered air to enter into the air cleaner. Also, in at least some embodiments, the present invention relates to an air cleaner including a housing and an additional component by which the air cleaner is capable of being directly coupled to a carburetor inlet. In some such embodiments, one or more protrusions can be provided within a channel formed by the housing/additional component to influence air flow. Further, in at least some embodiments, the present invention relates to an air cleaner having a shaped wall formed on a housing portion, where the shaped wall includes both an interior surface and an exterior surface by which air flowing within the air cleaner is imparted with helical motion.
US08419833B2 Apparatus and method for gas-liquid separation
A two phase gas-liquid separation apparatus is provided that shapes the flow in a flow shaping line. Shaping the two-phase flow allows centrifugal force to send the heavier, denser liquid to the outside wall of the flow shaping line and allows the lighter, less dense vapor or gas to occupy the inner wall of the flow shaping line. With the gas positioned on the inner wall of the flow shaping line, an exit port on the inner wall will allow for the majority, if not all, of the gas, along with a low amount of liquid, to be sent to a conventional separator. A high ratio of vapor/liquid at a flow rate much lower than the total flow rate within the flow shaping line is sent to the conventional separator. This allows for efficient separation of the vapor from the liquid with the use of a smaller conventional separator.
US08419826B2 Process for regeneration of adsorbent beds
The invention provides a process for the regeneration of at least one adsorbent bed, comprising at least the steps of: (a) contacting a first adsorbent bed (B1) with a gaseous stream (10) such that at least a portion of adsorbed species in said first adsorbent bed (B1) are released; (b) cooling a second adsorbent bed (B2); wherein a bypass (20) is provided around the second adsorbent bed (B2) and the gaseous stream (10), before contact with the first adsorbent bed (B1), is directed to at least one of (i) the second adsorbent bed (B2), and (ii) the bypass (20) around the second adsorbent bed (B2), wherein the proportion of gaseous stream (10) flowing through the bypass (20) is controlled.
US08419824B2 Method for producing briquette, method for producing reduced metal, and method for separating zinc or lead
An object of the present invention is to produce briquettes that have high strength even when the amounts of binder and water used are decreased as much as possible. A method for producing briquettes that achieve this object includes a step of forming primary granules by using a powder containing a metal oxide and at least one of zinc oxide, lead oxide, and titanium oxide and a step of compressing the primary granules still containing the at least one of zinc oxide, lead oxide, and titanium oxide so as to mold the primary granules into secondary granules.
US08419821B2 Method for treating spheroidal graphite iron and pouring device thereof
A method for treating spheroidal graphite iron includes the step: pouring molten spheroidal graphite iron into a pouring electrical furnace (1); covering the molten spheroidal graphite iron (5) with alkali slag (6) which is melted at high temperature and rich in alkali earth metal ion, rare earth metal ion, or mixture of them; connecting the molten spheroidal graphite iron (5) with the negative pole of the direct current source by one pole (7); connecting the alkali slag (6) with the positive pole of the direct current source by another pole (4), treating the molten spheroidal graphite iron (5) with the alkali slag (6) which is used as electrolyte. The method can prevent the spheroidized fading velocity of the spheroidal graphite iron. The pouring electrical furnace can be used for treating the molten spheroidal graphite iron.
US08419817B2 Self-supporting pleated filter media
The present invention is a filter that includes a length of filter media and a continuous, substantially nonlinear adhesive strand. The filter media has a front face and a rear face. The filter media has a plurality of pleats defined by a plurality of fold lines, each fold line being intermediate oppositely sloping first and second wall surfaces. The plurality of fold lines comprise a first plurality of pleat tips and a second plurality of pleat valleys. The adhesive strand is provided on the front face of the filter media in discontinuous contact with the filter media. The adhesive strand contacts the filter media at a pleat tip and contacts the filter media at a portion of a first wall surface and contacts the filter media at a portion of a second wall surface.
US08419816B2 Gas isolation valve
Provided is a gas isolation valve which separates reactive materials, principally gases, contained in a high temperature reactor from the surrounding atmosphere. The valve is of modular construction with each module having a gas providing section and a gas removal section. Any number of modules can be provided in series. A central chamber, open at each end gives unimpeded access to the high temperature reactor. It is through the central chamber that the product of the reactor is removed and harvested. In the case of Ilas invention the product is carbon nanotubes.
US08419815B1 Bird deflector and air replacement system
A bird deflector and air replacement system for a jet engine, the bird deflector being conical or arcuate in shape as formed by suitable longitudinal and lateral interconnected bars, and the air replacement apparatus being one of a frustum or a selectively perforated tube or a modified cowl with cooperating external spaced-apart channels or openings formed therearound for directing additional air into the mainstream of the jet engine inlet. The system may be manufactured as an aftermarket add-on, or it may be manufactured as original cowl equipment for respective jet engine models.
US08419814B2 Polycrystalline abrasive compacts
A method of manufacturing polycrystalline abrasive elements consisting of micron, sub-micron or nano-sized ultrahard abrasives dispersed in micron, sub-micron or nano-sized matrix materials. A plurality of ultrahard abrasive particles having vitreophilic surfaces are coated with a matrix precursor material in a refined colloidal process and then treated to render them suitable for sintering. The matrix precursor material can be converted to an oxide, nitride, carbide, oxynitride, oxycarbide, or carbonitride, or an elemental form thereof. The coated ultrahard abrasive particles are consolidated and sintered at a pressure and temperature at which they are crystallographically or thermodynamically stable.
US08419813B2 Integrated energy and/or synthesis gas production method by in-situ oxygen production, chemical looping combustion and gasification
The invention relates to an integrated method of in-situ oxygen production, chemical looping combustion and gasification of liquid, solid or gaseous fuels allowing combustion of coal, petroleum coke and/or liquid hydrocarbons and notably heavy and/or extra heavy or bituminous residues for production of synthesis gas under pressure and/or energy.
US08419811B2 Fuel composition
A fuel composition contains at least 74% by volume of C4 to C14 isoalkanes and, pursuant to the determination of the distillation characteristics according to DIN EN ISO 3405, at least 25% by volume of the fuel composition evaporate at temperatures above 110° C. The fuel composition can also contain oxygen-containing organic compounds, aromatic compounds, olefins, and naphthenes.
US08419809B2 Method of manufacturing solid electrolytic capacitor
A solid electrolytic capacitor having an even conductive polymer layer and a method of manufacturing the same are provided. The method of manufacturing a solid electrolytic capacitor includes the steps of forming a conductive polymer layer on an anode element by bringing a dispersion containing a conductive solid and a first solvent into contact with the anode element having a dielectric film formed thereon, washing the anode element with a second solvent higher in boiling point than the first solvent, in which the conductive solid can be dispersed, after the conductive polymer layer is formed, and drying the anode element washed with the second solvent at a temperature not lower than the boiling point of the first solvent and lower than the boiling point of the second solvent.
US08419807B2 Composition including a glyceride and an organophosphonic acid or one of the salts thereof, dyeing or colour-lightening method implementing same and devices
The present invention relates to a composition for coloring or lightening human keratin fibers, comprising, in a cosmetically medium: (a) at least 25 wt. % of one or more fatty substances; (b) one or more salified or unsalified organophosphonic acids; (c) one or more alkalizing agents and/or one or more dyes selected from oxidation dyes, direct dyes and mixtures thereof and (d) one or more oxidizing agents. It further relates to a method of coloring or lightening employing it. Another object of the invention is constituted by kits with two or three compartments for obtaining, after mixing the compositions from the compartments, just before its application, a composition according to the invention.
US08419801B2 Adjustable, remote-controllable orthopaedic prosthesis and associated method
An implantable, adjustable prosthesis includes a first component which may be moved relative to a second component by use of a transcutaneous control signal. A method of operating such a prosthesis is also disclosed.
US08419800B2 Prosthesis
A preassembled acetabular cup prosthesis comprising an outer shell and a ceramic liner located within the shell, said preassembled unit having been assembled ex-vivo under a controlled force selected to optimize the pre-stressing of the components of the prosthesis.
US08419799B2 Assembly tool for modular implants and associated method
An assembly tool (1) for assembly of a first component (2) of a prosthesis (4) to a second component (6) of the prosthesis (4) for use in joint arthroplasty is provided. The tool (1) includes a first member (8) operably associated with the first component (2). The first member (8) defines a first member longitudinal axis (10) of the first member (8). The tool also includes a second member (12) operably associated with the second component (6). The second member (12) defines a second member longitudinal axis (14) of the second member (12). The second member (12) is adapted to provide relative motion of the second member (12) with respect to the first member (8) when the second member (12) is rotated relative to the first member (8) about the second member longitudinal axis (14).
US08419793B2 Coating with antimicrobial agents
A coating with antimicrobial agents for use with medical devices. In one approach, a related method involves coating high temperature vulcanized silicone material with a room temperature vulcanized dispersion.
US08419788B2 Secured strand end devices
A woven, self-expanding stent device has one or more strands and is configured for insertion into an anatomical structure. The device includes a coupling structure secured to two different strand end portions that are substantially aligned with each other. The two different strand end portions include nickel and titanium. The coupling structure is not a strand of the device.
US08419787B2 Implantable intraluminal device and method of using same in treating aneurysms
A method and apparatus for reducing blood flow to an aneurysm proximate to a bifurcation having a source blood vessel a first branch vessel and a second branch vessel, the method comprising: providing a first mesh-like tube of bio-compatible material, the first mesh-like tube exhibiting a porosity index pre-selected to skew blood flow about the bifurcation away from the aneurysm; inserting the first mesh-like tube into the source blood vessel and the first branch vessel; and securing the first mesh-like tube to at least one of the source blood vessel and the first branch vessel, whereby blood flowing from the source blood vessel flows without undue impedance to the first branch vessel and the second branch vessel while being skewed away from the aneurysm.
US08419786B2 Self-expanding stent
The stent of this invention is a self-expanding stent created by a scaffolding lattice. The stent may be made from a nickel-titanium alloy. The lattice is formed from two different types of helices that proceed circumferentially in opposite directions along the longitudinal axis of the stent. The helices have no free ends. The first type of helix is formed by a series of undulations and the second type of helix is formed from a series of connection elements. The undulations may be in a zigzag or sinusoidal pattern. The connection elements connect the junction points lying on adjacent turns of the first type of helix. The junction points are formed by the ascending and descending arms of the undulations or zigzags. The ends of the stent may be formed by a closed circumferential element which is linked by connection elements to a transition zone. The transition zone is formed by a closed loop that connects directly to the first helix. The amplitude of the undulations or zigzags forming the transition zone increases from the closed loop to the point connecting the transition zone with the first type of helix. The closed circumferential element may be made from a radiopaque material. The scaffolding lattice design of the stent provides a stent having a high degree of flexibility as well as radial strength.
US08419780B2 Apparatus for securing an implantable object to bone
A fixation augmentation device (FAD) comprising a generally tubular body having a first end and a second end, said body having an opening adapted to receive a screw therein; a collar attached to the first end of said body, said collar having a non-circular shape and having an opening which is aligned with the opening in said body; and at least one flange disposed at the second end of said body, wherein said at least one flange is extendable from said body in response to a screw being inserted into the hole of said body.
US08419778B2 Uniplanar bone anchor system
The present teachings provide one or more surgical implements for repairing damaged tissue, such as in the case of a spinal fixation procedure. A uniplanar bone anchor system for a fixation procedure is provided. The system can include a bone fastener including a head with a bearing surface and a shaft adapted to engage an anatomy. The system can also include a saddle, which can include a first bore formed about a longitudinal axis that receives the bone fastener and a coupling bore defined transverse to the longitudinal axis. The system can also include a coupling system, which can have a second bearing surface. The coupling system can be received through the coupling bore such that the second bearing surface of the coupling system can contact the bearing surface to permit the bone fastener to move in only one plane.
US08419776B2 Radius-plate assembly
An assembly for reducing a fracture between an epiphysis and a diaphysis of a bone has a bone plate having a fan-shaped outer end formed with a plurality of outer holes and a bar-shaped inner end extending along a longitudinal axis from the outer end and formed with a plurality of inner holes. The plate further is formed on the bar-shaped inner end with a longitudinally extending throughgoing guide slot and between the guide slot and the outer holes with an aperture. A slide has a longitudinally extending leg with an inner end formed with a guide formation engaged into and longitudinally slidable along the guide slot and a crosspiece overlying the aperture and engaging the bone plate to both transverse sides of the aperture. The crosspiece is formed with a transversely elongated slide slot, and a slide screw engaged through the slide.
US08419768B2 Surgical stapling apparatus with powered articulation
The surgical stapling apparatus includes a handle assembly, an elongated body extending distally from the handle assembly, and an articulation mechanism for articulating a tool assembly. The articulation mechanism includes a first gear rotatably mounted on a transmission shaft and configured to engage a second gear, a clutch interconnecting the second gear and a main shaft; and a yoke shaft coupled to the main shaft and adapted to linearly advance a J-channel, the J-channel operatively connected to an articulation link. A motor assembly may rotate the transmission shaft of the articulation mechanism. Alternatively, the articulation mechanism may include an articulation knob. Users may manually rotate the articulation knob to articulate the tool assembly of the surgical stapling apparatus.
US08419767B2 Steerable atrial septal occluder implantation device with flexible neck
An atrial septal occluder device for repairing an atrial septal defect in a human heart includes an elongated catheter for insertion into and moved along a blood vessel and into the heart of a patient. The catheter includes a head portion, a tail portion and a neck portion between the head and tail portions. The neck portion is about 1 cm in length and 2 to 4 mm in diameter. The device also includes an Amplatzer ASO removably fixed to the head of the device and a moveable neck portion for positioning the ASO with respect to the ASD and an activator for closing the ASO over the ASD from outside of the patient's body.
US08419765B2 Medical apparatus
A medical instrument includes a swingable operating section formed of a pair of forceps which rock around a first rocking axis. A tubular sheath includes a distal end portion situated on a proximal end side of the operating section having a circular-section portion having a circular cross-section perpendicular to a longitudinal central axis and a pair of flat portions formed by cutting the opposite sides of the circular-section portion and in sliding contact with the proximal end portions of the forceps. A manipulator advances and retreats in a longitudinal direction of the sheath, thereby rocking the forceps. A junction connects the manipulator for rocking motion around a second rocking axis with respect to the forceps in the flat portions, and is situated on or near a reference plane passing through the longitudinal central axis of the sheath and extending parallel to the second rocking axis when the operating section is closed.
US08419761B2 Blood lancet device
This invention relates to a blood lancet device that is used to collect a small quantity of blood from a human body. More specifically, it relates to a blood lancet device that: can control the depth of the lancet needle's penetration of the skin; can push the lancet to eject; can accurately collect blood by ensuring linear motion; and can reduce the pain involved in blood collection.
US08419760B2 Cutting accessory for a powered surgical handpiece, the cutting accessory including features to facilitate the alignment of the accessory with the handpiece, hold the accessory to the handpiece, facilitate the transfer of torque to the accessory and reduce the wobble of the accessory
A surgical handpiece with a rotating spindle for receiving the coupling head of a surgical attachment or a cutting accessory. A gear train has plural drive heads that simultaneously rotate at different speeds. A clutch assembly has pins that move along the length of the spindle. The clutch assembly sets the position of the pins so they will engage one of the drive heads. The spindle rotates with the drive head with which the clutch pins are engaged.
US08419755B2 Obesity treatment tools and methods
Various obesity treatment tools and methods are described herein, as well as treatments for other gastric-related diseases, e.g., GERD. Treatment includes reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach directly from the interior of the stomach itself. The smaller pouches may be made through the use of individual anchoring devices, rotating probes, or volume reduction devices. A pyloroplasty procedure may also be performed to render the pyloric sphincter incompetent. A gastric bypass procedure may additionally be performed using atraumatic magnetic anastomoses devices so that sugars and fats are passed directly to the bowel while bypassing the stomach. Many of these procedures may be done in a variety of combinations. Treatment may create enforced behavioral modifications by discouraging the ingestion of high-caloric foods.
US08419753B2 Suturing device with split arm and method of suturing tissue
A device for suturing an opening in a tissue, having an elongated shaft, at least two arms movable to a deployed positioning which the arms are non-perpendicular to the shaft, the arms having needle receiving portions; and needles advanceable longitudinally along the shaft toward the needle receiving portions, the needles exiting through side walls of the shaft at a location proximal to the arms.
US08419750B2 Adjustable instruments for use with a localizer
A system for tracking the position of an instrument relative to an area of interest. The system includes an instrument and an instrument guide mounted to the instrument. The instrument guide carries a first localizer proximate the instrument. The first localizer is movable relative to the instrument. The system also includes a fixator configured to be attached to the area of interest. The fixator carries a second localizer proximate the area of interest. The second localizer is movable relative to the area of interest. The first and second localizers are movable in order that the first and second localizers are in communication such that the position of one of the first and second localizers is known relative to the position of the other of the first and second localizers.
US08419743B2 Assembly tool for modular implants and associated method
An assembly tool comprises in an assembled configuration a proximal implant fastener, a distal implant fastener, and a compression member. The assembly tool is operable to hold in the assembled configuration a proximal implant partially engageable with a distal implant during implantation and axial impaction. Axial impaction is exerted through the compression member of the assembly tool. The assembly tool is also operable to securely lock the tapers of proximal and distal implants after impaction by rotating the compression member.
US08419742B2 Instruments and method for preparing an intervertebral space for receiving an artificial disc implant
Instruments and methods for preparing an intervertebral space for receiving an implant. An adjustable trial implant has an adjustable stop mechanism having a stop member connected thereto to vary the distance that a body portion of the trial implant can move into the intervertebral space. Cutting tools for forming cutouts in the adjacent vertebrae use the trial implant and/or a guide to position a cutting tool which may be a burr or a chisel. The chisel cutting tool can be moveable relative to a selected trial implant or the chisel cutting tools can be fixed onto a trial implant shaped body portion.
US08419737B2 Bone grafting material condensing instrument and method of use
In an internal sinus manipulation procedure for augmenting bone of a dental patient between a bony floor of the patient's sinus and a raised portion of the patient's sinus membrane, employing a bone graft material condensing instrument comprising a longitudinally extending handle and a laterally extending distal head having an upper surface bounded by vertically extending substantially flat sides and a flat horizontally extending lower surface and placed within the raised portion of the patient's sinus membrane to condense a previously placed bone graft forming material upon a turning thereof.
US08419736B2 Sternal reconstruction system
A flexible cable for sternal reconstruction, the cable including first and second ends, the first end of the cable including a crimp fitting member, and the crimp fitting member including a flattened disk-like head. Also provided are methods for sternal reconstruction including wrapping a flexible cable having first and second ends around the sternum, tensioning the flexible cable to a desired tension and securing the tensioned cable, wherein the first end of the cable includes a crimp fitting member, and the crimp fitting member includes a flattened disk-like head.
US08419733B2 External fixation apparatus with adjustable pin clamping means
An external fixation device for holding bone fragments in place includes a housing having a number of rotationally adjustable pin holders, each of which is held by a clamping member that simultaneously clamps the pin holder within an internal mounting surface of the housing and a bone pin within the pin holder. A first embodiment includes a number of pin mounting structures, each of which can include a single pin holder. A second embodiment includes one or two pin mounting structures, each of which holds a row of pin holders that is clamped in place by a single clamping member. Other embodiments are formed by fastening together a group of elements to form different housing configurations.
US08419727B2 Impedance mediated power delivery for electrosurgery
An adaptive algorithm monitors the rate of tissue impedance change during an electrosurgical procedure. Impedance levels are examined to determine an impedance ramp and/or slope rate, which indicates the rate at which a target tissue is undergoing a phase or state change. The level of electrosurgical energy applied to the target tissue is adjusted in real time. Energy is applied to the target tissue at levels that allow tissue phase or state change to occur in an optimum fashion. Undesired results such as thermal damage and defective sealing are mitigated. Another embodiment determines impedance achieved within a specific interval and adjusts the electrosurgical energy applied to the tissue after a threshold impedance has been maintained or exceeded for a predetermined interval. A further aspect of the invention provides mitigation during processing for partial tissue coverage of device electrodes or thin tissue.
US08419726B2 Methods and devices for treating tissue
The invention provides a system and method for achieving the cosmetically beneficial effects of shrinking collagen tissue in the dermis or other areas of tissue in an effective, non-invasive manner using an array of electrodes. Systems described herein allow for improved treatment of tissue. Additional variations of the system include array of electrodes configured to minimize the energy required to produce the desired effect.
US08419723B2 Methods for treatment of prostatic tissue
A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe transurethrally. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Another feature of the prostate therapy system is that it can aspirate tissue from the prostate. Yet another feature of the prostate therapy system is that it can rotate during delivery of vapor and aspiration of tissue. Methods associated with use of the prostate therapy system are also covered.
US08419719B2 Target-close electromagnetic energy emitting device
An apparatus having an excitation source that includes at least one laser diode and also having a handpiece with a disposable, bendable tip cannula is disclosed.
US08419718B2 Laser handle and fiber guard
A protective handle for a mobile laser unit wherein the protective handle provides protection to a front section of the mobile laser unit from damage due to bumps and other impacts as the mobile laser unit is transported between treatment locations. The protective handle simultaneously acts to protect an attached optical fiber from damage during transport by limiting a bend radius of the laser fiber. The protective handle includes a U-shaped central segment having rear and forward surfaces defining a fiber optic support structure. The protective handle is attached to the mobile laser unit such that an optical fiber connector is centered within the U-shaped central segment and the optical fiber can rest on the fiber optic support structure.
US08419717B2 Control system configured to compensate for non-ideal actuator-to-joint linkage characteristics in a medical robotic system
A medical robotic system having non-ideal actuator-to-joint linkage characteristics, includes a control system including a proximal control loop with actuator sensor feedback to control dynamic response of an actuator coupled to a distal joint which in turn, is coupled to an end effector to provide a degree of freedom movement of the end effector, a distal control loop with distal joint sensor feedback and feedforward to the actuator to ensure steady-state convergence of the distal joint position, and an end effector control loop with end-point sensor feedback to control the end effector position to reach a commanded end effector position.
US08419715B2 Medical device with an energy supply having at least two energy sources
According to one embodiment, a medical device may include an energy supply. The energy supply may include a lithium-ion polymer battery including at least two battery stacks and a control unit. One of the at least two battery stacks may be a backup energy source. The control unit may monitor and control the energy supply such that when the control unit detects a fault in the at least two battery stacks, the control unit disconnects a faulty battery stack. The energy supply may be rechargeable. Each of the at least two battery stacks may include a positive potential terminal, a negative potential terminal and one or more battery cell.
US08419713B1 Carrier assembly with caps for medical connectors
An assembly for mounting medical connector caps includes a carrier formed from a sheet of material and having an array of holes. The assembly also includes a plurality of medical connector caps. Each cap is inserted into one of the holes of the array. The assembly also includes a plurality of sealing tabs. A distinct sealing tab includes a cover portion that sealingly covers the openable end of a corresponding one of the caps and includes an overhang portion that overhangs the openable end thereof. The overhang portion is dimensioned to include a tether of sufficient length that a tip of the tether overlaps an adjacent portion of the carrier. The tip is affixed to the carrier, so that the corresponding one of the caps is tethered to the carrier by such sealing tab.
US08419709B2 System for detecting and removing a gas bubble from a vascular infusion line
System for detecting and removing gas bubbles from a vascular infusion line, including a cassette adapted for disposition intermediate the fluid line, the cassette including a flexible tube having an inlet port for connection to a supply side of the fluid line, an outlet port configured for connection to a patient side of the fluid line, and a purge port intermediate the inlet and outlet ports, and a base unit adapted to receive the cassette and monitor fluid flow through the tube, the base unit including a sensor to detect the presence of a gas bubble in the fluid flow, a pinch valve adapted to stop the flow of fluid, and a control unit adapted to operate the base unit so that (i) fluid is permitted to flow past the pinch valve when no gas bubble is detected; and (ii) fluid flow is arrested when a gas bubble is detected.
US08419708B2 Transdermal drug administration apparatus having microneedles
It is intended to provide a transdermal drug administration apparatus having microneedles, which is capable of piercing the skin by a simple procedure in the transdermal administration of a biologically active substance (drug) and allows rapid absorption of the biologically active substance. The present apparatus comprises a microneedle device (50) comprising a microneedle substrate (53) having a plurality of microneedles (51) capable of piercing the skin, an absorbent (11) disposed thereon, the absorbent (11) comprising a material capable of absorbing a liquid, and a dissolving solution reservoir (18) disposed on the absorbent (11), the dissolving solution reservoir (18) containing a dissolving solution (16) for dissolving a drug and being capable of disrupting a diaphragm (20) provided the dissolving solution reservoir (18) and the absorbent (11) by pressing. A coating containing a dry drug is disposed on the microneedles (51) and/or the microneedle substrate (53).
US08419704B2 Absorbent article with fastening flaps
An absorbent article (1) includes an absorbent body (5) arranged superpositioned onto a backsheet (4). The absorbent article (1) has a side edge (6; 12a, 12b) encompassing the absorbent article (1). The absorbent article (1) includes at least one fastening tab (2) positioned along the side edge (6; 12a, 12b). In a first position the fastening tab (2) is folded over itself at least once creating at least one first pleat (13) and secured in its folded position by fastening means (17) positioned in the first pleat (13) on only a first side (14) of the fastening tabs (2), and in that in a second position, the fastening tab (2) is arranged to be unfolded at least partly for attachment to the outside and/or the inside of an undergarment (21).
US08419701B2 Absorbent articles with stretch zones comprising slow recovery elastic materials
An absorbent article may have at least one stretch zone comprising a slow recovery elastomer wherein the slow recovery elastomer exhibits a normalized unload force of greater than about 0.04 N/mm2 at 37° C.; and the slow recovery elastomer exhibits at least about 20% post elongation strain at 22° C. after 15 seconds of recovery from a 400% strain. The absorbent article may additionally comprises one or more of a liquid permeable topsheet, a liquid impermeable backsheet, an absorbent core, an ear, a side panel, a waist feature, a fastener component, a leg cuff, a gasketing cuff, and a barrier cuff, wherein the feature comprises at least a part of the stretch zone.
US08419700B2 Tampon overwrap
A packaged elongate intravaginal device has an overwrap substantially enclosing the device. The overwrap has a longitudinal overlap seam disposed generally parallel to the longitudinal axis. The seam includes one ply of overwrap material disposed at a first margin of a overwrap blank superposed on a second ply of overwrap material disposed at a second margin of the overwrap blank, opposite the first. The overwrap has a substantially continuous line of weakness that intersects a plane including the longitudinal axis of the packaged device at at least three unique locations. The line of weakness extends across the longitudinal overlap seam and includes weakness components superposed in each ply of the overlap seam, and the line of weakness is arranged and configured in a manner to permit the overwrap to remain as a unitary structure upon destruction of the line of weakness.
US08419697B2 Liquid collection system and related methods
Various embodiments of a fluid collection system having multiple storage chambers are disclosed. In an exemplary embodiment, the system may include a first chamber in fluid communication with a suction source and a second chamber in fluid communication with the first chamber. The second chamber may have a volume less than a volume of the first chamber. The second chamber may also comprise an inlet port for connecting to an external tube. The system may be configured to selectively drain liquid from the second chamber into the first chamber.
US08419695B2 Apparatus and method of maintaining insufflation
An apparatus includes a body configured to be at least partially inserted into a rectum of a patient. The body defines a first passageway and a second passageway between a proximal end portion and a distal end portion. The first passageway is configured to receive a medical tool and the second passageway is configured to communicate an insufflation medium. An insufflation port is coupled to the second passageway and is configured to communicate the insufflation medium to the second passageway. A retention portion is coupled to the body and is configured to have a dimension transverse to an axis defined by the body sufficient to retain at least a portion of the body in the rectum. The retention portion is configured to be located beyond an anus of the patient.
US08419694B2 Extension tube clamps for use with a catheter
A clamping assembly includes a first clamping member and a second clamping member. The first clamping member defines a first lumen dimensioned to non-rotatably engage a first portion of a tubular member. Rotating the first clamping member effects a rotation of the first portion of the tubular member. The second clamping member defines a second lumen dimensioned to non-rotatably engage a second portion of the tubular member. Rotating the second clamping member in relation to the first clamping member rotates the second portion of the tubular member in relation to the first portion of the tubular member to twist the tubular member to restrict flow through the tubular member.
US08419689B2 Enclosing package for medical port and cover
A securement device for securing a catheter to a patient is provided. The securement device includes a base including a support member and at least one securement arm extending away from the support member. The support member defines a cradle portion, the cradle portion of the support member being configured to receive at least a portion of a catheter. The at least one securement arm being movable over the cradle portion to a position to secure a catheter within the cradle portion. The securement device further includes a cover member configured to be received over the base and dimensioned to secure the base to a patient.
US08419687B2 Device for shielding a sharp tip of a cannula and method of using the same
A safety device for shielding a sharp tip of a tubular needle includes a shaft sized and shaped for being received into the passage of the tubular needle through a first end of the passage and extending to a second end of the passage. A shield is associated with the shaft and is constructed for receiving and substantially shielding the sharp tip of the needle. A catch is associated with the shaft. The catch prevents the withdrawal of the shaft from the passage of the needle when the shield is shielding the sharp tip of the needle.
US08419677B2 Balloon-tipped endoscopic system
Multi-luminal endoscopic systems for sterilely delivering deployable devices or obtaining bodily tissues. The system comprise an outer catheter comprising a wall that encloses an outer lumen; an inner catheter movably disposed within the outer lumen and having an inner lumen; a balloon-tipped catheter movably disposed within the inner lumen and having a distal end and a proximal end, wherein the distal end of the balloon-tipped catheter comprises a balloon tip that can be expanded to contact the wall of the outer catheter to provide a seal to prevent bodily fluids from entering the outer lumen; and a push catheter having a lumen and is located within the outer lumen. The delivery systems can comprise concentric catheters. Systems used for tissue collecting can comprise catheters with different common center.
US08419675B2 Applicator
An applicator insertable into a living body includes a nozzle having an elongated nozzle main body and a nozzle head on a front end side of the nozzle main body and through which a liquid together with a gas is expelled, with the nozzle main body including a flexible curved section. The applicator also includes an outer tube in which is positioned a portion of the nozzle main body so as to be movable along a longitudinal direction. The angle or degree of curvature of the curved section is changed by inserting the curved section into the outer tube to thereby adjust a direction of the nozzle head relative to a axis of the nozzle main body. In addition, a longitudinally extending gap exists between the outer tube and the nozzle. The gap functions as a discharge path for discharging gas within the body cavity.
US08419670B2 Frame for an orthopedic brace having a truss structure and an associated strapping system
A frame is provided for an orthopedic brace having an upper frame assembly, a lower frame assembly, a first hinge and a second hinge. The first and second hinges dynamically connect the upper and lower frame assemblies. The upper or lower frame assembly includes a truss unit which defines a triangle. The first side of the triangle is a substantially vertical longitudinal strut. The second side of the triangle is a first cross beam which is substantially horizontal or diagonal. The third side of the triangle is a diagonal second cross beam.
US08419669B2 Brace hinge with telescoping condyle pad
A knee brace assembly is provided having an adjustable, pressure-applying gear system mounted to a portion of the hinge assembly. Through selective adjustment of the gear system, the knee brace assembly can apply pressure to a portion or portions of the knee joint, thereby relieving pressure on the knee joint. A method of treating a knee joint using a knee brace assembly including a planetary gear system is also provided.
US08419668B2 Compact package for an orthopedic cast
A compact package for making an orthopedic cast is disclosed. The package comprises a fabric folded and compressed, having an initial over-all surface area, that, when saturated with water, expands to final over-all surface area that is larger by a factor greater than 50 than the initial over-all surface area. The expansion of the fabric occurs during a first time period. The package also includes a water-curable material, impregnated into the fabric, so that when the material is saturated with water, the material cures over a second period of time to become rigid, wherein the second period of time is substantially longer than the first period of time. When the package is used, the fabric impregnated with the material may be immersed in water and expanded. Once expanded and unfolded, the fabric may be placed around a portion of a body for which the orthopedic cast is desired. When the second time period elapses, the material has become rigid so as to form the orthopedic cast.
US08419667B2 Electric shower masseuse
The present invention is suspended between the shower sliding door frame and the opposite shower wall. It has two large rotating disk wheels that massage and clean the body. A water reservoir allows soapy water to flow gently onto both shower disk wheels continuously, enabling the user to limit the volume of water used. The disk wheels spin in opposite directions at the same speed, controlled by a single motor and a drive belt that rotates two shafts. The lower disk wheel moves forward and backward to conform to the contours of the body. The unit is braced against the back wall of the shower enclosure and kept in position by adjustable arms. It can be raised and lowered to clean the upper and lower body. Its speed and efficiency lead to conserving water, time, and energy. The invention is especially useful for anyone with limited hand or arm mobility.
US08419666B2 Compression sleeve
A compression sleeve includes a first sheet, a second sheet, at least one close-loop sealing contact and at least two open-loop sealing contacts. The at least one close-loop sealing contact is formed between the first and second sheet so as to form an isolated inflatable section within the close-loop sealing contact. The at least two open-loop sealing contacts are disposed within the at least one close-loop sealing contact, wherein at least one of the at least two open-loop sealing contacts includes two through holes respectively at two opposite ends.
US08419664B2 Massaging device
The invention relates to a massaging device in the shape of a rod having an essentially cylindrical end element, a shell forming the outer surface of the end element made of a rubber-elastic material and a drive unit for generating a motion on the end element, the drive unit forming a plurality of bearing and support surfaces, against which the shell bears and the bearing and support surfaces being designed for an oscillating deformation of the shell relative to the longitudinal axis (LA) of the end element radially outward and inward by means of radial stroke motions of the bearing and support surfaces. The massaging device features a first and second operating mode (T, W), in the first operating mode (T) the oscillating deformation along the longitudinal axis (LA) being in phase and in the second operating mode (W) out of phase.
US08419663B2 Massager
Disclosed is an apparatus for massaging the body of a user comprising an arcuate member extending between first and second opposed ends and a central portion therebetween. The first and second ends are oriented away from the central portion and the arcuate member defines an arc having an angle of less than 180 degrees. The apparatus further comprises gripping portions disposed at the first and second opposed ends and a therapy applicator connectable to the central portion.
US08419661B2 Upper limb measurement and rehabilitation method and system
A method for measuring an upper limb reaching capability of a user with an impaired limb is provided. Each upper limb is placed at a default position on a horizontal surface. A target is displayed from among a plurality of targets on the horizontal surface. One of the limbs reaches for the target. Limb choice, position information and elapsed time are sensed and recorded. The reaching limb is retracted to the default position. The displaying step through the retracting step are repeated for each of the plurality of targets, wherein each of the plurality of targets is spaced apart.
US08419657B2 Device for sampling bodily fluids
A bodily fluid sampling device comprising a lancet which can be advanced against a skin-piercing site to produce a droplet of bodily fluid. A transport medium is positioned sufficiently close to the lancing medium to retain a droplet of bodily fluid therebetween by capillary action. One of the two mediums has hydrophobic material on its surface and the other hydrophilic. Various mechanisms are provided for relatively displacing the lancing and transport medium to move the droplet of bodily fluid away from the skin-piercing end. Furthermore, multiple lancet assemblies may be provided in a barrel or disk configuration and indexed to the displacing mechanisms for sampling a skin site.
US08419654B2 Eye gaze tracking apparatus, imaging apparatus, eye gaze tracking method, program, and integrated circuit
An eye gaze tracking apparatus (100) includes: an electro-oculogram measuring unit that outputs an electro-oculogram original signal; a calibration index presenting unit (103) that presents a calibration index to a user; a saccade detection unit (104) that outputs an electro-oculogram change amount that is an amount of change in an electro-oculogram before or after a saccadic movement which is measured when a gaze-path position of the user moves to the calibration index; a calibration parameter calculating unit (105) that calculates a calibration parameter based on a position of the calibration index and an electro-oculogram change amount; and a calibration unit (101) that detects the gaze-path direction of the user from the electro-oculogram original signal.
US08419651B2 Spectrum analysis of coronary artery turbulent blood flow
A method includes acquiring vibrational cardiac data from an array of N transducers wherein the transducers are coupled to a human. A master replica is selected from a segment of the vibrational cardiac data. The master replica is correlated with the segment to obtain a plurality of local maxima. Vibrational cardiac data that were emitted during a diastolic interval are extracted from each heart cycle with the aid of the plurality of local maxima. A two-dimensional space-time frequency power spectrum is processed for Equivalent Rectangular Bandwidth, which provides estimates of the energy produced by turbulent blood flow through a coronary stenosis.
US08419644B2 Cordless charger for a wearable patient monitor
The present application discloses a cordless charger for a wearable patient monitor. When a patient (10) is diagnosed with a heart condition, or suspected heart condition, they are prescribed a patient monitoring system. The system includes monitors (12) that the patient (10) wears to collect the data of interest. Each day, the patient swaps the monitor (12) he or she is wearing with a fully charged monitor (12) from a cordless charger (14). In this manner, a fresh monitor (12) is always available for monitoring the patient (10). The cordless charger (14) includes a battery (50) that powers the processes of the charger and recharges batteries (34) of the monitors (12). Data from the monitors can be either offloaded to the charger memory (70), or transmitted to a remote database (32) via the patient's Bluetooth enabled cellular phone (30) or other like device.
US08419637B2 Sizing and positioning technology for an in-the-ear multi-measurement sensor to enable NIBP calculation
An in-the-ear (ITE) physiological measurement device (2) includes a structure (4) formed for easy insertion into multiple shaped and sized ear canals. An inflatable balloon (6) surrounds an end portion of the structure (4) to be positioned in the ear. Optionally, a mushroom shaped tip (22) is connected with an end of the structure (4) and carries a plurality of sensors (8). Inflation of the balloon (6) expands the tip (22) radially to position the sensors (8) proximate to vascular tissue within the ear canal. Once suitably positioned, the one or more sensors (8) sense physiological signals from the vascular tissue and bone structure.
US08419635B2 Surgical access device having removable and replaceable components
Methods and devices are provided to improve access to a surgical site during surgical procedures. In one exemplary embodiment a surgical access device is provided having a cannula, a cannula base, and a retractor. The cannula base is configured to couple both to the retractor and the cannula to provide access to a surgical site. The cannula can be removably and replaceably coupled to the cannula base. Optionally, the cannula base can be removably and replaceably coupled to the retractor. As desired, the cannula can be decoupled from the cannula base, which can allow for an object to be removed from the surgical site and/or for the cannula, or another cannula to be attached to the cannula base that remains in place to maintain access to the surgical site. Exemplary methods for accessing a surgical site are also provided.
US08419634B2 Apparatus and method for airway management
The claimed subject matter provides systems and/or methods that facilitate improving visualization associated with intubation. A dynamical articulating laryngoscope can include a handle assembly and a blade assembly. The blade assembly can further include a main blade assembly, a proximal blade assembly, and a distal blade assembly. A medium control articulation point can couple the main blade assembly and the proximal blade assembly, and a fine control articulation point can couple the distal blade assembly and the proximal blade assembly. Further, the proximal blade assembly can pivot relative to the main blade assembly around the medium control articulation point and/or the distal blade assembly can pivot relative to the proximal blade assembly around the fine control articulation point. Pivoting about the medium control articulation point and/or the fine control articulation point can be effectuated by one or more blade control components.
US08419628B2 Endoscope system and endoscopic image processing apparatus
An endoscope system includes: an endoscope equipped with an insertion portion, and an image pickup unit disposed at a distal end portion of the insertion portion; an illumination unit detachably connected to the endoscope; an imaging mode input unit used to set an imaging mode of the endoscope to one of a normal-light mode and a special-light mode; a processing condition selection unit which selects a processing condition for a color correction process of an endoscopic image based on the imaging mode; and a processor detachably connected to the endoscope and equipped with an image processing unit which performs the color correction process, under the processing condition selected by the processing condition selection unit, with respect to each of hue regions partitioned by at least eight reference color axes including six reference color axes which divide a color space into R (red), M (magenta), B (blue), C (cyan), G (green), and Y (yellow) hue regions and at least two reference color axes established additionally based on the imaging mode.
US08419625B2 Endoscope apparatus for cleaning transparent member
An endoscope apparatus includes a transparent member provided at a distal end of an insertion portion of an endoscope, opposed to an image pickup optical system, a transducer attached to an inner surface of the transparent member, a diffraction grating provided on an outer surface of the transparent member, for converting ultrasound vibration from the transducer to a surface acoustic wave Φ that propagates on the outer surface of the transparent member and a conversion section provided in an outer peripheral corner of the transparent member for converting the surface acoustic wave Φ to a bulk wave Φb that scatters into the transparent member.
US08419623B2 Portable endoscope for diverse medical disciplines
Disclosed herein is a portable endoscope and kit for performing multiple medical procedures. The portable endoscope comprises a detachable operator control section assembly and one of multiple detachable and interchangeable flexible insertion shaft assemblies with a flexible distal end. The proximal end of a detachable and interchangeable flexible insertion shaft assembly is detachably connected to the detachable operator control section assembly. The detachable and interchangeable flexible insertion shaft assembly accommodates principal cable wires, proxy cable wires, an optical imaging system, and an illumination system. An internal cable wire control system integrated with the detachable operator control section assembly utilizes an adaptable drive transmission system for controlling the orientation and angular position of the flexible distal end using the principal cable wires or the proxy cable wires. The proxy cable wires may be engaged in an event of failure of the principal cable wires.
US08419621B2 Capsule medical system and method for treating desired region inside subject
A capsule medical system includes a capsule medical apparatus, a selecting unit, and a control unit. The capsule medical apparatus is introduced inside a subject and includes an imaging unit for taking an in-vivo image of the subject, a treating unit for treating a living tissue in the subject, and a driving unit for contributing to movement of the capsule medical apparatus. The selecting unit selects a treatment target of the treating unit from the in-vivo image. The control unit determines a relative distance between the treatment target and the treating unit, and moves the capsule medical apparatus in an imaging direction of the imaging unit by a distance corresponding to the relative distance using the driving unit.
US08419618B2 Display device and in-vivo information acquiring system using the same
A display device includes: a display unit that displays examination procedure information indicating an examination procedure of a subject; and a control unit that acquires position-related information of a capsule endoscope inserted into the subject, calculates a position of the capsule endoscope based on the acquired position-related information, determines a to-be-executed examination procedure of the subject corresponding to the calculated position, and performs control to display the examination procedure information indicating the determined to-be-executed examination procedure of the subject.
US08419611B1 Intimate pleasure enhancing device
An intimate pleasure enhancing device 10 (IPED 10) that is presented in four designs that function in combination with an elongated structure (12). The first design utilizes a rear ring (30) that is attached by a first spring (58) to a movable first stimulator (42) located adjacent the front end (14) of the structure (12). The second design utilizes a rear ring (30) and a front ring (82). The front ring (82) is attached to the rear ring (30) by the first spring (58) and a second spring (72). The third design utilizes a front ring (82) that has attached a resilient member (92) located across the first end (14) of the structure (12). The fourth design utilizes a magnetic displacement assembly (104) that utilizes a set of similar polarity permanent magnets (120,134) that cause a front ring (82) to move along the outer surface (18) of the elongated structure (12). The IPED (10) can also be designed to function with a spring roller (150) that allows the first ring (82) to roll over the elongated structure (12).
US08419609B2 Impeller for a rotary ventricular assist device
An impeller for a blood pump such as a magnetically driven, rotary ventricular assist device for pumping blood of a patient, the impeller being substantially entirely made of an alloy which consists essentially of about 70-80 weight percent of platinum and 20-30 weight percent of cobalt.
US08419605B2 Arrangement for producing paper cushions
The present invention relates to an arrangement for producing paper cushions from a paper web which has been rolled up into a supply roll, the arrangement having a machine with a bearing arrangement for bearing the supply roll in a rotatable manner, and also having a device for forming the paper web and an arrangement for producing the paper cushions. The machine has coupling elements via which a transporting carriage provided with mating coupling elements can be coupled in a releasable manner to the machine, it being possible for a supply roll to be mounted on the transporting carriage such that, when the transporting carriage is coupled to the machine, the supply roll can be inserted into the bearing arrangement of the machine by way of a rolling and/or sliding movement.
US08419604B2 Apparatus for manipulating flat articles, such as sheets of paper, plastic, cardboard and the like
A device for manipulation of flat articles such as sheets of paper, plastic, cardboard and the like has at least one adjustable conveying unit with conveying elements, especially rollers. The at least one conveying unit is adjustable between at least two positions for performing at least two manipulations on the article. At least one switch that is adjustable between at least two positions for performing at least two manipulations on the article is provided.
US08419603B2 Method for folding sheets
A folding machine and a folding method perform overlapped folding of sheets of paper, paperboard and the like. The folding machine has at least one first and one second folding station each having driven folding rolls, a transport device disposed between the first and second folding stations, a drive and a common control unit connected to the drives. The products are transported between the first and the second folding stations in an overlapping manner.
US08419594B2 Exercise device for correcting posture
It is intended to provide a posture-correcting exercise device (10) having a novel structure by which an effect comparable to traction can be easily established without resorting to use a large-scaled apparatus and which can be easily and conveniently operated and yet is expected as achieving effects of, for example, correcting spine distortion and reinforcing muscles supporting the spine to thereby fundamentally reduce the load on the spine when appropriately operated. To solve the above problem, the posture-correcting exercise device (10) has a chin rest portion, on which the chin of a user (34) is placed, at the upper end face and a setting face at the lower end face. The outer periphery of the setting face serves as a tilting face (26) in a curved shape. When the user (34) puts his/her chin on the chin rest portion, the device is tiltable at the setting face.
US08419592B2 Engine automatic-stop/restart system
An engine automatic-stop/restart system resumes injection of fuel when an engine restart condition is satisfied, and energizes the starter motor when, after injection of the fuel has resumed, starting of the engine is not completed. The system can also control the coupling degree of a forward clutch under certain conditions, and energize a solenoid to engage a starter pinion with a crankshaft ring gear when their relative speeds are close to each other. The system then releases the forward clutch after the pinion and the ring gear have engaged.
US08419591B2 Vehicle drive system
In a drive system of a vehicle, the drive power of an engine is divided by a planetary gear set to drive two power transfer shafts. One of the two shafts includes a continuously variable transmission unit and a clutch. The output sides of the two shafts are coupled to a common power output shaft, which is coupled to an AC motor. In a power transfer condition of the clutch, the vehicle is driven with only the output drive power of the engine or both drive powers of the engine and the AC motor. In a power interruption condition of the clutch, the vehicle is driven with only the drive power of the AC motor. The kinetic energy generated at deceleration of the vehicle is converted into electric energy by the AC motor thereby to perform regenerative braking.
US08419588B2 Locking ring for a planetary gear set incorporated into a transmission member
A planetary gear set includes a carrier assembly. The carrier assembly includes a carrier member having a carrier member body that defines an inner carrier portion. The carrier member body includes a planet gear support surface and a carrier plate support member that extends substantially perpendicularly from the planet gear support surface. The carrier plate support member includes an edge portion having a mounting element. A carrier plate is arranged, at least in part, within the inner carrier portion at the edge portion. The carrier plate includes a carrier plate body having first and second opposing surfaces that define an outer edge section. The outer edge section includes a mounting member. A locking member is arranged in the mounting element and the mounting member to operatively coupling the carrier member and the carrier plate.
US08419587B2 Multi-ratio transmission
A multi step transmission comprising planetary gearsets (P1, P2, P3, P4), shafts and shift elements. The sun gear of gearset (P1) couples shaft (4) which couples housing (G) via brake (04). The carrier of gearset (P1) couples shaft (3), which couples housing (G) via brake (03), drive shaft (1) via clutch (13), and shaft (6) via clutch (36). Shaft (6) couples the ring gear of gearset (P2) and the sun gear of set (P4), and, via clutch (68), shaft (8), which couples the sun gear of gearset (P3). Shaft (1) couples the sun gear of gearset (P2) and the carrier of set (P3). Shaft (7) couples the ring gear of set (P1) and the carrier of gearset (P2). The ring gear of set (P4) couples shaft (5) which couples housing (G) via brake (05). Output shaft (2) couples the ring gear and carrier of gearsets (P3, P4) respectively.
US08419580B2 Electric wheel for electric vehicles
An electric wheel for electric vehicles includes a rim, connecting members, a hub motor, a battery, and a control device. The connecting members are connected to an inside of the rim and the hub motor is connected to the connecting members. The hub motor includes a shaft, a rotor and a stator. The shaft is located on a central axis of the rim and two ends of the shaft are fixed to a vehicle frame. The battery is located on the rim and the control device receives a wireless command signal and generating a control signal to control the battery to provide power to the hub motor, and to allow the hub motor to operate. The rim is equipped with the battery and the hub motor and directly connected to the vehicle frame without wires connected to the vehicle frame.
US08419575B2 Ball-type tensioner
A tensioner for a chain or similar power transmission medium comprises a spring-biased plunger having annular rack teeth with gradually sloping forward surfaces and steeper rearward surfaces. The teeth are engaged by radially movable balls received in inclined grooves in an axially movable annular ball seat disposed in an annular groove formed in the wall of a plunger-accommodating hole in a tensioner housing. The bottoms of the inclined grooves face a steep rearward surface of a rack tooth, and the annular ball seat is axially movable in the annular groove and biased in the plunger protruding direction by a spring that exerts a biasing force greater than the biasing force exerted on the plunger. The balls and the movable annular ball seat block retraction of the plunger on engine start-up, but permit retraction when excessive force is imparted to the plunger while the plunger is in a protruding condition.
US08419570B2 Golf ball
Golf ball 2 has a spherical core 4, a mid layer 6 covering this core 4, a reinforcing layer 8 covering this mid layer 6, and a cover 10 covering this reinforcing layer 8. Base polymer of the mid layer 6 includes an ionomer resin as a principal component. The mid layer 6 has a hardness Hm as measured with a Shore D type hardness scale of equal to or greater than 55. Base polymer of the reinforcing layer 8 is a thermosetting resin. Base polymer of the cover 10 includes a thermoplastic polyurethane elastomer as a principal component. The cover 10 has a thickness Tc of equal to or less than 0.6 mm. The cover has a hardness Hc as measured with a Shore D type hardness scale of equal to or less than 54. Ratio (Tr/Tc) of the thickness Tr of the reinforcing layer to the thickness Tc of the cover is 0.005 or greater and 3.0 or less.
US08419567B2 Golf coupling mechanisms and related methods
Embodiments of golf coupling mechanisms are presented herein. Other examples and related methods are also disclosed herein.
US08419558B2 Child carrier apparatus and its operating method
A child seating apparatus comprises a support frame, a seat assembly mounted with the support frame, a pivot joint and an actuating mechanism. The pivot joint includes a first coupling element connected with the support frame, a second coupling element connected with the seat assembly and pivotally assembled with the first coupling element, and a latching member movable between a first position locking the first and the second coupling element in position, and a second position unlocking the second coupling element from the first coupling element. The actuating mechanism includes a casing, and a handle movably assembled through the casing and is connected with the latching member via a link element, whereby the handle is operable with a single hand to cause the latching member to move from the first position to the second position. In some embodiments, a method of operating the child seating apparatus is also described.
US08419557B2 Waterslide assembly and system
The present disclosure provides a waterslide that may include a flexible slide portion and an anchor portion. The anchor portion may secure the slide portion to a surface and may include a tab element, a stake element, and an adhesive element.
US08419551B2 Rotary shaft device
In a rotary joint for a rotary shaft device, ring-shaped inner seals and outer seals are projectingly arranged, and concentric with faces of a front joint disk and a rear joint disk opposing with each other respectively. A ring-shaped inner space communicates with forward communication holes, and a ring-shaped outer space communicates with backward communication holes. The inner and outer space are adjacently arranged concentrically between the inner seals and the outer seals. The forward communication holes and the backward communication holes in the reciprocating flow passages and the front joint disk are arranged at an equal distance in the peripheral direction of the opposing faces.
US08419546B2 Gaming system and method for selectively providing an elimination tournament that funds an award through expected values of unplayed tournament games of eliminated players
A gaming system including a central server operable to communicate a plurality of different commands to a plurality of gaming devices to provide non-tournament game play and provide an elimination tournament. The gaming system contributes an average expected payout value of tournament games that were determined to be subsequently played by tournament players but were then not played because the players were eliminated before the end of the tournament to a tournament award. The tournament award is provided to a winner of the tournament.
US08419545B2 Method and system for controlling movements of objects in a videogame
Techniques for controlling movements of an object in a videogame are disclosed. At least one video camera is used at a location where at least a player plays the videogame, the video camera captures various movements of the player. A designated device (e.g., a game console or computer) is configured to the video data to derive the movements of the player from the video data, and cause the object to respond to the movements of the player. When the designated device receives video data from more than one locations, players at the respective locations can play a networked videogame that may be built upon a shared space representing some or all of the real-world spaces of the locations. The video game is embedded with objects, some of which respond to the movements of the players and interact with other objects in accordance with rules of the video games.
US08419541B2 Smart shell to a game controller
Devices, systems, and methods of use are presented for a smart shell that can be fitted by an end user to a video game controller that routes signals from various buttons or other sensors on the smart shell to a video game console. Signals can flow from the video game console back to the shell to operate tactile feedback motors, lights, or speakers. The smart shell can be clipped to the game controller by the end user and released after a game is played. The smart shell can be in the shape of a gun with sensors to determine which grips are being held and a sensor to determine if a player is holding the gun's scope to his face. Logic using the three sensors can robustly determine whether the user is holding the gun as a pistol, machine gun, or a sniper rifle, and can reflect the player's choice of style in the video game.
US08419538B2 Storage medium storing game program, game apparatus and game control method
A game apparatus includes an LCD, and a game screen is displayed on the LCD. A touch panel is provided on the LCD. The game screen presents a marker image so as to be variable in position in time with performance of music, and also presents a timer circle image for indicating touch timing for the marker image. A player needs to touch a marker image to be touched with precise timing, listening to the music or watching the timer circle image. The player's touch is evaluated on the basis of the touch timing and the touch position. If the touch is evaluated as a failure, the game screen is shaken.
US08419532B2 Distributed promotional coupon system for a gaming environment
Methods and apparatuses for a distributed promotional coupon system for use within a casino which has cash-less gaming machines involving a plurality of game installed cash-out Voucher Printers networked to a central server. A central coupon server harnesses the processing power of the plurality of printers, tasking each one to analyze the player activity of the game into which it is installed. Handshaking and signaling between the server and the plurality of printers ensure that the server was system master, approving the issuance of all coupons. One advantage of the system is the simplification of the server whose real-time processing requirements become more of data routing than analysis.
US08419531B2 Methods, systems, and computer program products for determining an integrity measure of a game user using dynamically generated data events
The subject matter described herein includes methods, systems, and computer program products for determining an integrity measure of a game user using dynamic performance events. According to one aspect, the method includes providing a plurality of predetermined data events in a gaming interface for sending to a client device and inserting, during sending of the gaming interface to the client device, at least one dynamically generated data event into the predetermined data events for determining an integrity measure of a game user. After sending gaming interface to a client device, input response to the at least one dynamically generated data event is received. Based on the input response to the at least one dynamically generated data event, a game user integrity measure is determined.
US08419530B2 Method of gaming, a game controller and a gaming system
An example method of gaming includes: conducting a progressive jackpot including a prize defined by a plurality of digits; and incrementing the progressive jackpot by incrementing a digit of said plurality of digits of the prize in response to a trigger event corresponding to the digit occurring.
US08419527B2 Wagering game account management system
A wagering game account management system and its operations are described herein. In embodiments, the operations include determining that a trigger condition for an account rule has occurred, wherein the account rule specifies an account action to be performed upon satisfaction of the trigger condition, and wherein the account action is associated with a wagering game account and other financial accounts. In some embodiments, the operations also include initiating the account actions and indicating a result of the account actions.
US08419526B1 Methods and apparatus for providing tickets from gaming devices and/or lottery terminals
Gaming devices dispense tickets which are unrelated to a player's success on a particular game played on a gaming device or to the player's credits on a credit meter or other “cash out” indicator. The gaming devices provide gaming awards and also provide tickets. Other methods provide tickets during the play of wagering games. Still other embodiments comprise lottery terminals which dispense tickets other than those purchased by a lottery patron or won on a purchased lottery ticket.
US08419523B2 Gaming machine in which symbol involving possibility of winning prize is illuminated
A slot machine 10 includes: reels 101-105 each having symbols 501; backlight devices M7 which individually light the symbols 501; a display window 150 which displays the symbols 501; and a motherboard 70 programmed to run a game in which the reels 101-105 are rotated to rearrange the symbols 501, and a prize is awarded according to a combination of the symbols 501. The motherboard 70 (a1) drives and rotating the reels 101-105; (a2) stops the rotation of a predetermined reel; (a3) causes a backlight source M70 of a backlight device M7, which corresponds to a winning-related symbol 501 out of the symbols 501 rearranged, to be in an on-state while causing a backlight source M70 of a backlight device M7 corresponding to a non-winning-related symbol 501 to be in an off-state; and (a4) executes (a3) every time the rotation of at least one of the reels 101-105 is stopped.
US08419522B2 Apparatus and method for mapping multiple bingo game results to a common display
Apparatus and methods are described for presenting multiple bingo game results on a common display. A bingo game player may participate in a number of bingo games and obtain results for each of those games. These bingo game results are combined to amount to a cumulative result, and a common graphic display is produced that is representative of the cumulative result. The common graphic display is then shown to the player on the display device of a particular electronic player station.
US08419519B2 Wagering game with symbols forming an altered array or secondary array
A gaming system for conducting a wagering game includes an input device for receiving a wager to play a wagering game. The gaming system further includes a primary display (14) for displaying a first array of symbols (173) that indicates a randomly selected outcome of the wagering game. The gaming system further includes a secondary display (16) for displaying a secondary array of symbols (181) that indicates a secondary outcome of the wagering game. In response to a predetermined criterion, at least one winning symbol (175a, 175c) is moved from a first position in the first array to a second position in the secondary array to create a modified secondary array that indicates a winning outcome.
US08419515B1 Magnetic register vent cover and associated method
An air register for diffusing air away from an existing air duct may include a body with an open panel and plurality of louvers situated therealong. The body may include a plurality of planar side walls extending orthogonally to the panel and disposed inwardly from an outer perimeter thereof. A mechanism may be included for articulating the interconnected louvers between open and closed positions. A second mechanism may be included for magnetically affixing the planar walls to the existing air duct. In operation, the magnetically affixing mechanism may be automatically displaced outwardly and away from the planar side walls while the interconnected louvers biasing mechanism is toggled between the open and closed positions. In this manner, the body may be maintained at a substantially stable position during articulation of the interconnected louvers by maintaining the magnets firmly against the walls of the air duct.
US08419514B2 Apparatus for circulating air
Disclosed is an apparatus for circulating air. The apparatus comprises a hollow handle assembly having a proximal end and a distal end. The apparatus further includes an air circulation assembly pivotally secured to the proximal end of the hollow handle assembly. The air circulation assembly is capable of generating an air-flow. Moreover, the apparatus includes a connecting fixture coupled to the distal end of the hollow handle assembly. The connecting fixture is capable of being received in a receptacle for a lighting appliance and for providing an electrical connection to the apparatus for circulating the air. The air circulation assembly is adapted to have an angular motion in all directions about the hollow handle assembly.
US08419511B1 Chicken mid-wing splitter
An apparatus for splitting poultry mid-wings into separate radius and ulna portions. The apparatus includes a plurality of carrier blocks mounted to a drive chain that drives the carrier blocks along a path in a continuous loop around the apparatus. Each carrier block has recesses formed in it that cooperate with recesses formed in adjacent carrier blocks to form carrier slots that hold mid-wings in a predetermined orientation. A blade member having an upper blade and a lower blade extends into the path and is aligned with blade channels formed in the carrier blocks. The blade member bisects mid-wings that are held in the carrier slots as they move downstream. The carrier blocks rotate downwardly about the downstream end of the path and are separated from one another, thereby opening the carrier slots. The separated mid-wings contained in the slots are thereby allowed to fall out of the slots.
US08419505B2 Tumbled, polished, vibrated broken tempered glass pieces
An invention is provided for creating smoothed, heat-treated glass fragments. The invention includes placing a plurality of heat-treated glass fragments into a tumbling or vibrating apparatus. Each heat-treated glass fragment is formed from glass that has been heated to a temperature of at least 1000° Fahrenheit and rapidly cooled to a temperature below 700° Fahrenheit. The plurality of glass fragments are then tumbled or vibrated for a predetermined period of time such that surfaces of the heat-treated glass fragments are smoother than prior to tumbling. The glass fragments are thereafter removed from the tumbling apparatus, resulting in smoothed, heat-treated glass fragments that are suitable for direct handling without hand protection.
US08419503B2 Cushioned brassiere
A molded brassiere cup is disclosed in which an underwire is located between sheets of material which provide the outer and inner surfaces of the brassiere cup. During manufacture an insert of a cushioning substance, preferably a piece of foam, is located between the inner sheet of material and the underwire. The invention avoids prior art complex casing structures for underwires and is cheaper to manufacture.
US08419495B2 Switchable particle-based display and method of manufacturing same
A method for manufacturing a switchable PBD includes filling a plurality of first-type particles and a plurality of second-type particles into each cell, where the plurality of first-type particles carries charges of a first charge polarity having a first charge density and the plurality of second-type particles is substantially electrically neutral, or carries charges having a second charge density that is substantially lower than the first charge density of the first-type particles, and filling a fluid into each cell, where the fluid comprises a charge controlling agent having a second charge polarity opposite to the first charge polarity, and the charge controlling agent has a substantially selective wettability, absorbability or adsorbability on the plurality of second-type particles. As such, at least part of the plurality of second-type particles is charged to have the second charge polarity in each cell.
US08419494B2 Flat panel display device and method of manufacturing the same
A flat panel display device and a method of manufacturing the same. The method of manufacturing the flat panel display device includes: forming a display on a substrate; preparing an organic layer mask comprising a first mask body, a regulator extending from the first mask body and contacting the organic layer, and a tunnel having a space between the first mask body and the regulator; forming an organic layer covering the display in a region divided by the regulator of the organic layer mask, and condensing a part of the organic layer permeating through the tunnel; preparing an inorganic layer mask; and forming an inorganic layer covering the organic layers formed in the region divided by the regulator through the inorganic layer mask and in the tunnel.
US08419492B2 Printing bead spacers on flat panel display substrates
An apparatus for printing bead spacers on a substrate of an LCD panel includes a head unit for spraying a plurality of bead spacer groups on the substrate, a transfer unit for transferring the head unit, and a supply unit for supplying the bead spacers to the head unit. Each of the bead spacer groups includes a plurality of bead spacers, and the sizes of the respective spacers of at least two of the spacer groups are different from each other. The invention enables a cell gap of a substantially uniform thickness to be created and maintained in the panel, prevents the occurrence of smear failures in the panel, and increases the allowable tolerance in the amount of liquid crystal material needed to fill the panel correctly.
US08419491B2 Method for manufacturing a spark plug for preventing deformation caused by cutting a center electrode
When a movable blade cuts a distal end portion of a ground electrode member and is pulled back along a cut surface formed at a distal end of the ground electrode member, the distal end portion may move in the pull-back direction of the movable blade due to friction generated between the movable blade and the cut surface. This movement could cause deflective deformation of the ground electrode member. In order to restrain such movement, a support part is provided on the movable blade via a spring located near the cut surface. During the pull back step, the support part presses and supports the portion of the cut ground electrode member near the distal end thereof. Therefore, even when friction is generated when the movable blade is pulled back, the ground electrode member does not undergo deflective deformation.
US08419490B1 Retractable tether and dye (RTD) combined with a portable floatation device (PFD)
The present application discloses a device designed to be used on board of ships, vessels, boats. The device consists of a retractable tether having two ends a first end and a second end. Said first end to be securely connected to the body of said ship. Said second end to be securely connected to a personal floatation device. Said retractable tether thus connects the seaman wearing it to the body of the ship or vessels. During normal operations the seaman can enjoy additional room to move by extending a retractable reel from a retractable reel assembly. When an out of the ordinary tension is applied as when the seaman is ejected by the ship, the tether breaks dispersing in the water an high visibility dye in the water. A portable floatation device then helps the seaman to be kept afloat while waiting for aid to come.
US08419487B2 Internally mounted watercraft rowing fin system
An internally mounted rowboat rowing fin system that includes two rotating fin assemblies mounted on the inside surface of the watercraft's opposite sidewalls. Each fin assembly includes a rotating vertical post held on the inside surface of the sidewall by a mounting tube selectively mounted or integrally formed on the sidewall. Longitudinally aligned and disposed inside each mounting tube is a hollow, elongated sleeve. Disposed inside each elongated sleeve is a rotating post that extends upward above the gunwale and into the water below the elongated sleeve. A pivoting fin arm with a flexible fin attached thereto is pivotally attached to the lower end of each rotating post. Attached to the upper end of each rotating post is a perpendicularly aligned handle bracket. A rowing handle is pivotally attached at one end to the handle hinge. During use, the two handles extend inward from the sidewall and are grasped by the rower. Both handles are able to swing in a vertical 180 arc over their respective handle hinges thereby allowing the fins to rotate 180 and sweep in opposite directions.
US08419485B2 Bulkhead connector assembly
A bulkhead connector assembly is provided having an outer housing that has an internal chamber. The outer housing has a sealing section configured to seal an exterior of the outer housing within an opening. A terminal housing is configured to hold a plurality of terminals. The terminal housing is received in the internal chamber. The terminal housing has primary locking mechanisms configured to secure the terminals in the terminal housing. An independent secondary lock (ISL) is separately provided from, and coupled to, the terminal housing. The ISL is configured to secure the terminals in the terminal housing and assure they are properly seated.
US08419482B1 Electrical connector
A power connector mounting on a printed circuit board (PCB), includes an insulating housing, and a number of power contacts received in the housing. The insulating housing extends along a transversal direction and defines a number of passageways extending therethrough along a front-to-back direction. The insulating housing has a top wall, an opposite bottom wall, and a pair of side walls. A beam is provided inside of the passageway. Each power contact has a main portion, a pair of contacting fingers extending from a forward edge of the main portion and distal tails extending downwards from the main portion. The pair of contacting fingers defining a groove therebetween for engaging with the beam so as to facilitate the contact being secured in the passageway with respect to said insulating housing.
US08419478B2 Dual-card connector
A dual-card connector for receiving dual SIM (Subscriber Identification Module) cards therein includes an insulating housing, a plurality of conductive terminals, an upper cover and a lower cover. The insulating housing has a base body. A top and a bottom of the base body define two sets of longitudinal terminal grooves. Each set of the terminal grooves is divided into a front row and a rear row penetrating a front end and a rear end of the base body, respectively. The conductive terminals are received in the corresponding terminal grooves of the insulating housing for electrically connecting with the respective SIM cards. The upper cover is covered to the insulating housing to form a first insertion space therebetween for receiving a first SIM card. The lower cover is covered to the insulating housing to form a second insertion space therebetween for receiving a second SIM card.
US08419477B1 Electrical connector
An electrical connector includes an insulating housing, a number of power contacts and a number of signal contacts received in the insulating housing, and a power bus bar electrically and mechanically connecting with one power contact. The insulating housing defines an opening at a rear side thereof, and defines a number of first and second passageways extending therethrough and communicating with the opening. The power contacts are received in corresponding first passageways and the signal contacts are received in corresponding second passageways. Each power contact is composed by a pair of opposite power contact halves. Each power contact half defines a contacting end and an engaging end opposite to the contacting end. A fish-shape slot is defined between the two engaging ends.
US08419476B1 Electrical connector
An electrical connector for connecting a cable includes an insulating housing with power contacts and signal contacts received therein, a power bus bar connecting with one power contact, and a spacer receiving the power bus bar. The insulating housing includes a mating face, a mounting face opposite to the mating face and defines first and second passageways extending therethrough. Each power contact forms a first engaging portion and a first contacting portion. Each signal contact forms a second engaging portion and a second contacting portion. The power bus bar has a main section extending along a first plane, a middle section extending from the main section, and a connecting section extending along a second plane perpendicular to the first plane.
US08419475B2 Modular open fuseholder with multi-stage positionable cover
A modular fuse holder includes a cover that is movable from a closed position to an open position relative to a base along two different paths of motion to prevent inadvertent opening or closing of the cover.
US08419463B2 Coaxial connector
A surface mount type coaxial connector 1 to be mounted on a circuit wiring board 50 comprises: a contact 10 for signals having a cylindrical fitting portion 11 for signals divided by first slits 111a housing 20 having a circular convex portion 22 which surrounds the fitting portion 11 for signals via a first space S1; and a ground shell 30 having a circular fitting portion 32 for ground which surrounds the convex portion 22 via a second space S2, and the contact 10 for signals, the housing 20, and the ground shell 30 are integrally formed by insert molding.
US08419459B2 Connector port
A connector port provided on the outer surface of a housing of an electronic device includes: a connector holding section that is formed in the housing and has a connector opening; and an opening/closing cover including an attaching section that is screwed to the connector holding section, a flat cover section that is pivotably supported by the attaching section at the proximal end thereof and opens and closes the connector opening, and an elastically deforming section that is provided at the distal end of the cover section and elastically deforms to engage in the connector holding section. The connector holding section is formed as a recess on the outer surface of the housing, the opening/closing cover is housed in the recess, and the outer surface of the housing and the outer surface of the cover section are substantially flush with each other.
US08419453B2 Cable connector
A cable connector is disclosed. The cable connector includes a male connector and a female connector. The male connector includes a male base and male terminals received in the male base. The female connector includes a female base and female terminals locked with the female base. Two posts respectively protrude outwardly from ends of two side walls of the male base. Two locking slots which are tilting are respectively defined in the middles of two side walls of the female base. When assembled, the male base is pushed so that the posts are respectively locked with the corresponding locking slots. The male base of the present invention is steadily locked with the female base. Furthermore, the male base of the present invention is disassembled from the female base by pushing the male base, so that the posts are withdrawn from the locking slots.
US08419452B2 Electric connector and endoscope
An electric connector portion includes first and second electric contact portions which are connectable to first and second target electric contact portions, respectively, and a protective member which is movable from a protecting position where the first and second electric contact portions are protected to an opening position where the first and second electric contact portions are opened in a moving direction extending from the first electric contact portion side to the second electric contact portion side, wherein the protective member includes an opening portion which is configured to open the second electric contact portion when the protective member is arranged at the opening position.
US08419450B2 Conductor line, collector and conductor system
The invention relates to: a conductor line (2) for powering at least one device (11) that can travel along the conductor line (2), comprising a first elongated conductor lane (5b) and at least one other, second elongated conductor lane (6b), wherein the first (5b) and second (6b) conductor lanes comprise a first (5f) and a second (6f) contact opening, respectively, running along the length of the respective lane, for holding a part (15a; 16a) of a first (15) and a second (16) respective conductor contact of a collector (14) of the device (11); a collector (3) comprising at least one first conductor contact (15) provided for engaging into a first contact opening (5f) running along the length of a first conductor lane (5b) of the conductor line (2) and for electrically connecting to the first conductor lane (5b); and a conductor line system (1) formed therefrom. The invention accomplishes the objective of enabling a simple, fast, but non-mistakable connection of a specific conductor contact to a specific conductor lane of a conductor line, using a conductor line (2), a collector (14) and a conductor line system (1), wherein the second contact opening (6f) of the second conductor lane (6b) is adapted so that the first conductor contact (15) provided for connecting to the first conductor lane (5b) cannot engage into the second contact opening (6f) and cannot be connected to the second conductor lane (9).
US08419448B2 Elastic connector, method of manufacturing elastic connector, and electric connection tool
The present invention provides technology with high production efficiency for an elastic connector that electrically connects two connection target members. The technology enables an initial product to be quickly completed with a low initial cost, in correspondence to any distance between the connection target members and any angle formed between them. An elastic connector was obtained by forming a major-axis columnar body, in which a conductive part was formed by cross linking and hardening (solidifying) conductive members inside a tube-like part formed of an insulative rubber tube, and then cutting the major-axis columnar body with a cutting blade along a cutting line, which is in a direction crossing the axis of the major-axis columnar body, to shorten the major-axis columnar body. This elastic connector eliminates the need to create a new metal mold in its manufacturing. When a length to which the major-axis columnar body is cut is appropriately changed and it is cut to that length, an elastic connector that suit any distance between the connection target members and any angle formed between them can be obtained.
US08419446B2 Electrical connector having contacts with solder portion pointing opposite directions
An electrical connector includes an insulative housing with a plurality of passageways arranged in a matrix. A contact includes a base for securing the contact in the passageway, a spring portion and a soldering portion extending from the base. The soldering portions of the contacts laid in a row of the passageways are alternately arranged toward two opposite sides of the base to form two rows. Such array of soldering portions of the contact can improve contact density.
US08419445B1 Memory card with a connector
A memory card with a connector includes a card main body for storing data and a connector including multiple terminals and an insulation main body. Multiple terminal soldering sections are disposed on the card main body. The multiple terminals are integrally connected with the insulation main body to form the connector. In manufacturing, the connector integrally composed of the terminals and the insulation main body is directly rested on the card main body. Then, in a one-time soldering process, all the terminals are soldered on the terminal soldering sections of the card main body. Accordingly, the manufacturing process is simplified and the manufacturing cost is lowered. Also, the ratio of good products is increased.
US08419444B2 Adapter for high-speed ethernet
An adapter includes a mechanical frame, which is configured to be inserted into a SFP-type receptacle and contains a socket for receiving a plug of a twisted-pair-type cable. First electrical terminals, held by the mechanical frame, are configured to mate with a connector in the receptacle. Second electrical terminals, held within the socket, are configured to mate with electrical connections of the plug. Circuitry connects the first and second electrical terminals so as to enable interoperation of the plug with the receptacle.
US08419443B2 Electric connection box
For an object of providing an electric connection box which can relax limitation of arranging electric components and connectors of a wiring harness, the electric connection box includes a box main body having a plurality of cassette blocks in which a relay is mounted. A fusible link is mounted at one cassette block. A top surface of the one cassette block is arranged at a higher position than a top surface of the cassette block adjacent to the one cassette block. The plurality of cassette blocks is arranged to locate each of the top surfaces thereof lower one by one in proportion to parting from the one cassette block.
US08419441B1 System for electrically connecting a pair of circuit boards using a pair of board connectors and an interconnector received in apertures of the circuit boards
A system for electrically connecting circuit boards includes a pair of board connectors configured to be electrically connected to respective circuit boards. Each of the board connectors includes a plurality of electrical conductors and a housing configured to enclose at least a portion of the electrical conductors. An interconnector includes a plurality of electrical conductors, each of which is configured to be electrically connected to a respective electrical conductor of the board connectors, thereby electrically connecting the circuit boards. An interconnector housing is configured to cooperate with the housings of the board conductors to at least partially enclose the electrical connections between the electrical conductors of the interconnector and the board connectors.
US08419439B2 Apparatus and related methods for the controlled illumination of a convex surface
Illumination provided to the interior of a convex surface can be controlled using a plurality of internal barriers separating light sources such as light emitting diodes. Such controlled illumination can simulate phases of the moon using logic which can be limited to yes or no Boolean decisions, thereby minimizing the complexity of required input.
US08419434B2 Interactive recipe preparation using interactive cooking device to communicate with kitchen appliances
A user selects a recipe from a list of recipes. Preparation steps corresponding to the selected recipe are retrieved from a data store, such as a database. Each of the retrieved preparation steps is displayed sequentially to the user on a horizontal surface display that is included in an interactive cooking preparation device. During at least one preparation step, a selected kitchen appliance is identified, such as a configurable burner surface. The identified preparation step also includes one or more appliance parameters that correspond to the selected kitchen appliance. The selected kitchen appliance is controlled by sending one or more signals from the interactive cooking preparation device to the selected kitchen appliance. At least one of the signals sent to the appliance includes one of the appliance parameters.
US08419431B2 Preformed provisional crowns and methods for constructing temporary dental crowns and bridges
Apparatuses and methods for providing crowns and bridges is disclosed. The apparatuses include provisional preforms which can have cavities, windows and slits that enable material and linear members to extend through for engagement with adjacent teeth or other preforms. The methods also include ways in which to create crowns and bridges using the preforms.
US08419426B2 Device for positioning and immobilizing a surgical guide in a patient's mouth
The invention relates to a positioning and immobilization device for positioning and immobilizing a mandibular or maxillary surgical guide on a patient, which guide is adapted to preparing for and to fitting at least one dental implant and is provided with a link slab member designed to extend outside the oral cavity when the surgical guide is placed in register with the patient's mandible or maxilla, said positioning and immobilization device being characterized in that it comprises a body that has bearing face for bearing against the outside of the head of the patient, and a fastener designed to co-operate with the link slab member of the surgical guide.
US08419424B2 Functional orthodontic appliance with an extraoral device
A functional orthodontic appliance including a facebow as an extraoral device for treating malpositions of the jaws or teeth. The functional orthodontic appliance includes a pad holder which is fastened to a transition area of the facebow and can be individually positioned and adjusted by very simple means. Preferably, the pad holder is provided with one pair of pads or a twin plate which is/are placed inside the lower lip in the vestibule that is displaced downward. The inventive appliance makes it possible to do functional orthodontic therapy of the lower jaw with all known advantages while correcting the position of the teeth in the upper jaw.
US08419413B1 Mold core positioning device
A mold core positioning device configured to position a mold core includes a base and a sleeve assembly. The base defines a receiving space. The sleeve assembly includes a hollow sleeve and a number of balls. A number of receiving holes are defined in a sidewall of the sleeve, and each of the receiving holes holds one of the balls, and each of the balls can rotate freely in a corresponding receiving hole. The sleeve is received in the receiving space, and the balls received in the sleeve is to hold the mold core in position with the balls contacting the mold core.
US08419412B2 Nano-imprint mold and substrate with uneven patterns manufactured by using the mold
According to one embodiment, a nano-imprint mold includes plural pairs of first and second protrusions formed on a base layer, each of which is formed along the same straight line. Each protrusion has a top surface and four side surfaces. The first and second protrusions are mirror-symmetrical with each other. A first side surface of the first protrusion and a second side surface of the second protrusion face each other. A first angle between the first side surface or the second side surface and a main surface of the base layer is not less than 85° and not more than 90°. A second angle between a third side surface in the first protrusion or a fourth side surface in the second protrusion and the main surface of the base layer is not less than 70° and not more than 88°. The first angle is larger than the second angle.
US08419411B2 Aerosol container
An aerosol container (1), comprising:—a reservoir (2) containing a propellant and a foodproduct;—operable discharge means (3) to discharge the foodproduct;—a dispensing head (10) defining a foodproduct receiving space (11) to receive the foodproduct from the discharge means (3), a distal part (15) of the head (10) having foodproduct shaping projections (12), wherein the foodproduct receiving space comprises an upstream foodproduct receiving space (11A, 11B) that widens, viewed in a foodproduct discharge direction, wherein a maximum diameter (D1) of the foodproduct receiving space of the dispensing head is larger than about 2 cm.
US08419406B2 Dynamic mould tool
Mould tool to be arranged in a press with essentially parallel press surfaces for production of rigid expanded polymer embryo bodies, the mould tool comprises a first mould member and an second mould member that are moveable with respect to each other in a direction perpendicular to the press surfaces, and sealing means providing an essentially hermetic seal between the first and second mould member during at least a portion of such a relative motion, thereby defining a closed mould cavity of variable volume, wherein the first mould member defines at least a portion of the mould cavity volume and comprises an outer peripheral edge, and the second mould member comprises a rim that closely circumscribes the outer peripheral edge of the first mould member and wherein the sealing means is arranged in the gap formed between the rim and the outer peripheral edge.
US08419405B2 System for forming a composition with an optimized filler
The particle size distribution of a first fly ash is compared to an ideal particle size distribution that was empirically developed to provide a resin melt with a lower viscosity as more fly ash is added. A second fly ash material is similarly compared to the ideal curve and then is blended or optimized to provide an optimum filler for use with a suitable resin or similar material. Additional fly ash materials may be similarly compared and blended. Additional additives may be added for, among other things, foaming and coloration.
US08419403B2 Conveyer of honeycomb formed article and conveying method thereof
There is disclosed a conveyer and a conveying method that enable conveying a lengthy honeycomb formed article extruded at a high speed with a simple apparatus without causing cracks and deformation. The conveyer of a honeycomb formed article includes a plurality of lengthy cradles that are sequentially supplied and then sequentially support and convey the honeycomb formed article, and a fixed support that is fixed so as to extend from the extruder to a supply position of the lengthy cradles, supports the honeycomb formed article just after being extruded, and conveys it to one of the lengthy cradles, and the fixed support is an air float having a supporting face and a plurality of air ejection pores formed on the supporting face that conveys the honeycomb formed article by feeding air from the air ejection pores.
US08419401B2 Method and device for dispensing sealant within a gap
A nozzle head for dispensing sealant within a gap is provided. The nozzle head includes, but is not limited to, a body section and a port connected with the body section. The body section forms a primary channel through which sealant is dispensed. The primary channel forms an entrance through which sealant enters the body section and an exit through which sealant is dispensed from the nozzle. The port is connected with the body section and surrounds the exit. The port forms a chamber having a tip portion opposed to a rear opening. The chamber forms an angled path from the tip portion to the rear opening to trap and guide excess sealant within the chamber to the rear opening.
US08419397B2 Screw compressor
A screw compressor includes a casing, a screw rotor and a gate rotor. The casing has a cylinder. The screw rotor is cylindrical-shaped and configured to be fitted into the cylinder. The gate rotor is configured to be engaged with the screw rotor. A, outlet width of a seal surface of the casing on a gas-outlet side of the screw rotor is larger than an inlet width of the seal surface on a gas-inlet side of the screw rotor. The seal surface of the casing is opposed to one surface of the gate rotor.
US08419393B2 Compressor having bearing assembly
A compressor may include a shell, a compression mechanism, a drive shaft, and first and second bearing housing assemblies. The compression mechanism may be supported within the shell and the drive shaft may have a first end drivingly engaged with the compression mechanism. The second bearing housing assembly may be located within and fixed to the shell. The second bearing housing may include a radially extending base portion defining an aperture rotatably supporting a second end of the drive shaft therein. The second bearing housing may additionally include a wall portion extending axially from the base portion and having a first region coupled to the shell at a first location, a second region coupled to the shell at a second location and a third region extending from the first region to the second region.
US08419391B2 High pressure pump
A fuel gallery has a first opening port communicated to a variable volume chamber formed at a lower side of a plunger and a second opening port communicated to a fuel pressurizing chamber formed at an upper side of the plunger. A connecting tube member is provided in the fuel gallery for communicating the first and second opening ports with each other. During a fuel amount adjusting stroke, for example, in which the plunger is moved in an upward direction, a part of excessive fuel from the fuel pressurizing chamber is supplied to the variable volume chamber through the connecting tube member and the remaining part of the excessive fuel is discharged from the connecting tube member into the fuel gallery through a communication through-hole formed in the connecting tube member.
US08419382B2 Piston compressor
A compressor includes a rotary shaft, a cam, a cylinder block, pistons, a thrust bearing, a rotary valve, and an oil passage. The rotary shaft has an in-shaft passage formed therein. The in-shaft passage has an outlet open to the outer peripheral surface of the rotary shaft. The cam rotates integrally with the rotary shaft. The pistons are coupled to the rotary shaft through the cam. The thrust bearing is provided between the cam and the cylinder block. The thrust bearing includes a first race in contact with the cam, a second race in contact with the cylinder block, and rolling elements retained between the first and second races to form a gap therebetween. The oil passage is formed in the outer peripheral surface of the rotary shaft so as to extend from the gap to the outlet of the in-shaft passage.
US08419380B2 Hermetic compressor
A noise reducing device for a hermetic type compressor is provided that includes a plurality of cylinders disposed at upper and lower portions thereof, a communication path that provides for communication between inlets of the plurality of cylinders, and a suction pipe coupled to an inlet of one of the plurality of cylinders. Such an arrangement may reduce a number of components and simplify the fabrication process. Accordingly, fabrication costs may be reduced, and vibration due to resonation of a plurality of suction pipes may be avoided. Further, such an arrangement may provide enhanced performance by optimizing a specification of the suction pipe and a suction path thereof.
US08419378B2 Jet pump
A fluid mover (1) includes a hollow body (2) provided with a straight-through passage (3) of substantially constant cross section with an inlet end (4) an outlet end (5) for the entry and discharge respectively of a working fluid. A nozzle (16) substantially circumscribes and opens into the passage (3) intermediate the inlet (4) and outlet (5) ends. An inlet (10) communicates with the nozzle (16) for the introduction of a transport fluid and a mixing chamber (3A) is formed within the passage (3) downstream of the nozzle (16). The nozzle internal geometry and the bore profile immediately upstream of the nozzle exit are disposed and configured to optimise the energy transfer between the transport fluid and working fluid. In use, through the introduction of transport fluid, the working fluid or fluids are atomized to form a dispersed vapor/droplet flow regime with locally supersonic flow conditions within a pseudo-vena contracta, resulting in the creation of a supersonic condensation shock wave (17) within the downstream mixing chamber (3A) by the condensation of the transport fluid. Methods of moving and processing fluids using the fluid mover are also disclosed.
US08419375B2 Method of making a rotor yoke and rotor yoke thereof
A method of making a rotor yoke includes preparing a cured composite rotor yoke preform on a single-sided curing tool and machining at least one portion of the cured rotor yoke preform to form a rotor yoke. In one embodiment, preparing the cured composite rotor yoke is accomplished by applying successive layers of uncured polymeric composite material to a single-sided tool in a configuration to produce an uncured rotor yoke preform; disposing a semi-rigid caul to an untooled side of the uncured rotor yoke preform; enclosing the uncured rotor yoke preform and the semi-rigid caul by substantially hermetically sealing a vacuum bag to the tool; substantially evacuating a volume defined by the vacuum bag and the tool of air; and heating the uncured rotor yoke preform, sometimes under pressure, to form the cured composite rotor yoke preform.
US08419374B2 Gas turbine engine composite blade
The disclosed composite airfoil includes a three-dimensional composite core extending longitudinally and having a chord-wise direction. The core has a core in-plane thickness extending between opposing sides in a through-plane direction generally perpendicular to the chord-wise and longitudinal directions. A composite skin covers the opposing sides and has an exterior surface providing an airfoil contour. The skin includes a total skin in-plane thickness corresponding to a sum of thicknesses through the skin in the through-plane direction from each of the opposing sides to their adjoining exterior surface. A sum of the core in-plane and total skin in-plane thicknesses at a central portion of the composite airfoil is a total in-plane thickness. The total skin in-plane thickness at the central portion is less than 50% of the total in-plane thickness.
US08419373B1 Wind turbine blade, wind turbine generator equipped with wind turbine blade and method of designing wind turbine blade
It is intended to provide a wind turbine blade with superior aerodynamic characteristics and rigidity, a wind turbine generator equipped with the wind turbine blade, and a method of designing the wind turbine blade. The wind turbine blade 1 is provided with a blade tip part 2, a blade root part 4 connected to a hub 112, and an airfoil part 6 disposed between the blade tip part 2 and the blade root part 4. The airfoil part 6 includes a flatback airfoil 10 with a blunt trailing edge 8 at least in an area in a longitudinal direction of the wind turbine blade 1 where a blade thickness ratio X is 40% to 50%. X indicates a ratio of a maximum thickness tMAX to a chord length LC. In the area where the blade thickness ratio X is 40% to 50%, the flatback airfoil has a trailing edge thickness ratio Y which is 5% to YH%, Y indicating a ratio of a trailing edge thickness tTE to the maximum thickness tMAX and YH has a relationship of YH=1.5X−30 with the blade thickness ratio X.
US08419371B2 Wind turbine blades with twisted and tapered tips
A blade for a wind turbine includes a total backward twist of between approximately 6 degrees and approximately 15 degrees between an outer approximately 1 percent to approximately 10 percent of a rotor radius of the blade; and a total normalized chord change of between approximately one percent and approximately two percent between the outer approximately 1 percent to approximately 10 percent of the rotor radius of the blade.
US08419370B2 Retaining and sealing ring assembly
A fan blade retaining and sealing ring assembly for an aft side of a bladed disk assembly is disclosed herein. The ring assembly includes an inner ring operable to prevent aft movement of a fan blade positioned in a slot formed in the blade disk. The ring assembly also includes an outer ring operable to seal against a platform of the fan blade. The inner ring and the outer ring are formed from different materials.
US08419364B2 Fan with an arrangement of detecting degradation of the bearings
The fan has an arrangement for monitoring the ageing of at least one of its bearing, the arrangement including a reference ambient temperature sensor and a processing circuit for comparing the temperature difference between the temperature measured by the temperature sensor or by each temperature sensor fitted directly on the corresponding bearing and the temperature measured by the reference temperature sensor with a first predetermined value.
US08419362B2 Foldable blades for wind turbines
A turbine blade assembly includes an outboard blade section that folds onto an inboard blade section at a hinge located between the sections. When the outboard blade section is rotating to a folded position a longitudinal axis of the outboard blade section is transverse to a longitudinal axis of the inboard blade section. When the outboard blade section is in a fully folded position, the axes are parallel. The method of folding the outboard blade section includes adjusting the pitch of the turbine blade while it is rotating. Adjusting the pitch changes the pressure on a non-hinge side of the turbine blade and results in the outboard blade section folding with respect to the inboard blade section.
US08419361B2 Anti fret liner assembly
An anti-fret assembly for a turbine engine, the assembly comprising an elongated liner having first and second walls connected by a base to provide a generally U-shaped channel, the liner having an outer surface adapted to lie against a first component and an inner surface adapted to lie against a second component at least the first wall being provided with a notch for receipt of an anti-translation pin, the assembly further comprising an anti-translation pin.
US08419360B2 Multi-blade centrifugal fan
A multi-blade centrifugal fan for preventing circular flows in the end portions of an impeller in the axial direction is provided in a simple structure. The multi-blade centrifugal fan is formed of a fan casing of a scroll type and a multi-blade centrifugal impeller. The fan casing has a bellmouth which becomes an air intake. The multi-blade centrifugal impeller has a number of annularly arranged blades inside the fan casing. The centrifugal impeller draws in air through the intake, which faces the bellmouth, and blows out the air in the centrifugal direction through the blades. A retainer ring is provided in an outer peripheral end portion of the impeller. A cylindrical body is integrally provided in such a manner as to extend from the outer end of the retainer ring, so that circular flows toward the intake side are prevented in the end portions of the impeller.
US08419358B2 Flow output nozzle for centrifugal pump
A flow outlet for a pump includes a pocket section which defines a pocket section diameter. A throat section downstream of the pocket section, the throat section defines a throat section diameter less than the pocket section diameter.
US08419357B2 Apparatus and method for reducing the pressure on a joint between at least two delimiting parts
An apparatus, especially a steam turbine, including a first delimiting part and a second delimiting part is provided. The delimiting parts are attached to one another forming a joint and enclosing at least a part of a first pressure chamber. A shielding element is also provided on the sides of the delimiting parts facing towards the first pressure chamber and is arranged to form a seal completely covering the joint, so that a cavity is formed between the delimiting parts and the shielding element. A line is routed in the cavity connecting the cavity to a second pressure chamber. In addition, a method for decreasing the force acting on a joint, which is formed by the joining together of a first delimiting part and a second delimiting part of an apparatus, especially a steam turbine, and for reducing the attachment forces acting on the joint is provided.