Document Document Title
US08421150B2 High voltage device and manufacturing method thereof
The present invention discloses a high voltage device and a manufacturing method thereof. The high voltage device is formed in a first conductive type substrate, wherein the substrate has an upper surface. The high voltage device includes: a second conductive type buried layer, which is formed in the substrate; a first conductive type well, which is formed between the upper surface and the buried layer; and a second conductive type well, which is connected to the first conductive type well and located at different horizontal positions. The second conductive type well includes a well lower surface, which has a first part and a second part, wherein the first part is directly above the buried layer and electrically coupled to the buried layer; and the second part is not located above the buried layer and forms a PN junction with the substrate.
US08421149B2 Trench power MOSFET structure with high switching speed and fabrication method thereof
A fabrication method of trench power semiconductor structure with high switching speed is provided. An epitaxial layer with a first conductivity type is formed on a substrate. Then, gate structures are formed in the epitaxial layer. A shallow doped region with the first conductivity type is formed in the surface layer of the epitaxial layer. After that, a shielding structure is formed on the shallow doped region. Then, wells with a second conductivity type are formed in the epitaxial layer by using the shielding structure as an implantation mask. Finally, a source doped region with the first conductivity type is formed on the surface of the well. The doping concentration of the shallow doped layer is smaller than that of the source doped region and the well. The doping concentration of the shallow doped layer is larger than that of the epitaxial layer.
US08421146B2 Semiconductor device having vertical transistor, manufacturing method thereof, and data processing system
A semiconductor device includes: a semiconductor substrate; a silicon pillar provided perpendicularly to a main surface of the semiconductor substrate; a gate dielectric film that covers a portion of a side surface of the silicon pillar; an insulator pillar that covers remaining portions of the side surface of the silicon pillar; a gate electrode that covers the silicon pillar via the gate dielectric film and the insulator pillar; an interlayer dielectric film provided above the silicon pillar, the gate dielectric film, the insulator pillar, and the gate electrode; and a gate contact plug embedded in a contact hole provided in the interlayer dielectric film, and in contact with the gate electrode and the insulator pillar. A film thickness of the insulator pillar in a lateral direction is thicker than a film thickness of the gate dielectric film in a lateral direction.
US08421145B2 Power semiconductor device
Provided is a power semiconductor device including a semiconductor substrate, in which a current flows in a thickness direction of the semiconductor substrate. The semiconductor substrate includes a resistance control structure configured so that a resistance to the current becomes higher in a central portion of the semiconductor substrate than a peripheral portion of the semiconductor substrate.
US08421143B2 Nonvolatile semiconductor memory device having element isolating region of trench type
Disclosure is semiconductor device of a selective gate region, comprising a semiconductor layer, a first insulating film formed on the semiconductor layer, a first electrode layer formed on the first insulating layer, an element isolating region comprising an element isolating insulating film formed to extend through the first electrode layer and the first insulating film to reach an inner region of the semiconductor layer, the element isolating region isolating a element region and being self-aligned with the first electrode layer, a second insulating film formed on the first electrode layer and the element isolating region, an open portion exposing a surface of the first electrode layer being formed in the second insulating film, and a second electrode layer formed on the second insulating film and the exposed surface of the first electrode layer, the second electrode layer being electronically connected to the first electrode layer via the open portion.
US08421140B2 Dielectric structures
A capacitor structure and method of forming it are described. In particular, a high-K dielectric oxide is provided as the capacitor dielectric. The high-K dielectric is deposited in a series of thin layers and oxidized in a series of oxidation steps, as opposed to a depositing a single thick layer. Further, at least one of the oxidation steps is less aggressive than the oxidation environment or environments that would be used to deposit the single thick layer. This allows greater control over oxidizing the dielectric and other components beyond the dielectric.
US08421137B2 Magnetic random access memory
A device includes a magnetic tunnel junction (MTJ) structure and a cap layer in contact with the MTJ structure. The device also includes a spin-on material layer in contact with a sidewall portion of the cap layer and a conducting layer in contact with at least the spin-on material layer and a portion of the MTJ structure. The cap layer has been etched to expose a portion of an electrode contact layer of the MTJ structure. The conducting layer is in electrical contact with the exposed portion of the electrode contact layer of the MTJ structure.
US08421133B2 Detector module
A detector module, in particular for super-resolution satellites, contains a multi-chip carrier. At least one TDI-CCD detector and at least one CMOS chip are arranged on the multi-chip carrier, and are electrically connected to one another. The CMOS chip contains at least the digital output electronics for the TDI-CCD detector.
US08421126B2 Double-sided integrated circuit chips
Semiconductor structures. The semiconductor structures include two silicon-on-insulator wafers having devices fabricated therein and bonding them back to back utilizing the buried oxide layers or bonding them back to back utilizing an inter-substrate dielectric layer and a bonding layer between the buried oxide layers. The structures include contacts formed in the upper wafer to devices in the lower wafer and wiring levels formed on the upper wafer. The lower wafer may include wiring levels. The lower wafer may include landing pads for the contacts. Contacts to the silicon layer of the lower wafer may be silicided.
US08421121B2 Antimonide-based compound semiconductor with titanium tungsten stack
An apparatus in one example comprises an antimonide-based compound semiconductor (ABCS) stack, an upper barrier layer formed on the ABCS stack, and a gate stack formed on the upper barrier layer. The upper barrier layer comprises indium, aluminum, and arsenic. The gate stack comprises a base layer of titanium and tungsten formed on the upper barrier layer.
US08421120B2 Field effect transistor capable of reducing shift of threshold voltage
A problem is arisen in conventional J-FETs that a shifting in a threshold voltage (VT) is generated before or after an energization with a gate current. A junction gate field effect transistor (J-FET) according to the present invention includes an undoped InGaAs channel layer 5, which is capable of accumulating carrier of a first conductivity type, a p+ type GaAs layer 17 (semiconductor layer), which is provided on the undoped InGaAs channel layer 5, and contains an impurity of a second conductivity type, and a gate electrode 18, which is provided on the p+ type GaAs layer 17. Here, the concentration of hydrogen contained in the p+ type GaAs layer 17 is lower than the concentration of the second conductivity type carrier in the p+ type GaAs layer 17.
US08421116B2 Light emitting device and method for manufacturing the same
The light emitting device of the invention comprises a first electrode, a second electrode being light transmitting, and a carrier sandwiched between the first electrode and the second electrode and containing light emitters, wherein the first electrode has a plurality of projections or a pn junction formed with a p-type semiconductor and an n-type semiconductor each on a surface being in contact with the carrier.
US08421107B2 Group-III nitride semiconductor light emitting device and production method thereof, and lamp
A group III nitride semiconductor light emitting device including an LED structure formed on top of a single crystal, base layer (103) formed on top of a substrate (101) including a principal plane (10) having a flat surface (11) configured from a (0001) C plane, and a plurality of convex portions (12) including a surface (12c) non-parallel to the C plane having a width (d1) of 0.05 to 1.5 μm and height (H) of 0.05 to 1 μm, the base layer is formed by causing a group III nitride semiconductor to grow epitaxially so as to cover the flat surface and convex portions, and the width (d1) of the convex portions and top portion thickness (H2) of the base layer at the positions of the top portions (12e) of the convex portions satisfy: H2=kd1 (wherein 0.5
US08421103B2 Semiconductor light emitting device and light emitting device package including the same
A semiconductor light emitting device is provided. The semiconductor light emitting device comprises a plurality of compound semiconductor layers, an electrode layer, a conductive support member and a first buffer member. The compound semiconductor layers comprise a first conductive semiconductor layer, an active layer and a second conductive semiconductor layer. The electrode layer is disposed under the plurality of compound semiconductor layers. The conductive support member is disposed under the electrode layer. The first buffer member is embedded to be spaced apart, in the conductive support member.
US08421098B2 Semiconductor light emitting device having a roughness on a channel layer
Disclosed is a semiconductor light emitting device. The semiconductor light emitting device includes a light emitting structure including a first conductive semiconductor layer, an active layer below the first conductive semiconductor layer, and a second conductive semiconductor layer below the active layer; a channel layer below the light emitting structure, in which an inner portion of the channel layer is disposed along an outer peripheral portion of the light emitting structure and an outer portion of the channel layer extends out of the light emitting structure; and a second electrode layer below the light emitting structure.
US08421089B2 Light emitting device
A light emitting device includes a substrate, a first lead frame and a second lead frame on the substrate, an installation portion electrically connected to the first lead frame or the second lead frame, the installation portion being thinner than the first lead frame or the second lead frames, a light emitting diode on the installation portion, and a conductive member electrically connecting at least one of the lead frames to the light emitting diode.
US08421085B2 Semiconductor light-emitting device
According to one embodiment, a semiconductor light-emitting device includes a first semiconductor layer of a first conductivity type, a second semiconductor layer of a second conductivity type, a light-emitting layer, a third semiconductor layer and a first electrode. The light-emitting layer is provided between the first and second semiconductor layers. The third semiconductor layer is provided on opposite side of the first semiconductor layer from the light-emitting layer, has a lower impurity concentration than the first semiconductor layer, and includes an opening exposing part of the first semiconductor layer. The first electrode is in contact with the first semiconductor layer through the opening. The third semiconductor layer further includes a rough surface portion which is provided on opposite side from the first semiconductor layer and includes a surface asperity larger than wavelength in the third semiconductor layer of peak wavelength of emission light emitted from the light-emitting layer.
US08421084B2 Organic light emitting display and manufacturing method thereof
An organic light emitting display includes a gate electrode on a substrate, an active layer insulated from the gate electrode, source and drain electrodes that are insulated from the gate electrode and contact the active layer, an insulating layer between the active layer and the source and drain electrodes, a light blocking layer that is on the active layer and that blocks light of a predetermined wavelength from the active layer, and an organic light emitting device that is electrically connected to one of the source and drain electrodes.
US08421081B2 Memory device, memory module and electronic device
The first transistor includes first and second electrodes which are a source and a drain, and a first gate electrode overlapping with a first channel formation region with an insulating film provided therebetween. The second transistor includes third and fourth electrodes which are a source and a drain, and a second channel formation region which is provided between a second gate electrode and a third gate electrode with insulating films provided between the second channel formation region and the second gate electrode and between the second channel formation region and the third gate electrode. The first and second channel formation regions contain an oxide semiconductor, and the second electrode is connected to the second gate electrode.
US08421080B2 Thin-film transistor array device, organic EL display device, and method of manufacturing thin-film transistor array device
A thin-film transistor array device includes: a driving TFT including a first crystalline semiconductor film including crystal grains having a first average grain size; and a switching TFT including a second crystalline semiconductor film including crystal grains having a second average grain size that is smaller than the first average grain size. The first crystalline semiconductor film and the second crystalline semiconductor film are formed at the same time by irradiating a noncrystalline semiconductor film using a laser beam having a Gaussian light intensity distribution such that a temperature of the noncrystalline semiconductor film is within a range of 600° C. to 1100° C., and the first crystalline semiconductor film is formed such that the temperature of the noncrystalline semiconductor film is within a temperature range of 1100° C. to 1414° C. due to latent heat generated by the laser irradiation.
US08421078B2 Thin film transistor substrate and method for manufacturing same
A thin film transistor (TFT) substrate includes gate lines, data lines intersecting with the gate lines, a plurality of TFTs, pixel electrodes, and a common electrode insulating the gate lines, the data lines, the TFTs, and the pixel electrode. Each pixel electrode is connected to one of the gate lines and one of the data lines via one of the TFTs. A layer stack including an insulating layer and a passivation layer is sandwiched between the pixel electrodes and the common electrode.
US08421077B2 Replacement gate MOSFET with self-aligned diffusion contact
A replacement gate field effect transistor includes at least one self-aligned contact that overlies a portion of a dielectric gate cap. A replacement gate stack is formed in a cavity formed by removal of a disposable gate stack. The replacement gate stack is subsequently recessed, and a dielectric gate cap having sidewalls that are vertically coincident with outer sidewalls of the gate spacer is formed by filling the recess over the replacement gate stack. An anisotropic etch removes the dielectric material of the planarization layer selective to the material of the dielectric gate cap, thereby forming at least one via cavity having sidewalls that coincide with a portion of the sidewalls of the gate spacer. A portion of each diffusion contact formed by filling the at least one via cavity overlies a portion of the gate spacer and protrudes into the dielectric gate cap.
US08421075B2 Light emitting device, light emitting device package, and lighting system including the same
A light emitting device, a light emitting device package, and a lighting system are provided. The light emitting device includes a first conductive type semiconductor layer, a second conductive type semiconductor layer, and an active layer between the first and second conductive type semiconductor layers. The active layer includes a first active layer adjacent to the second conductive type semiconductor layer, a second active layer adjacent to the first conductive type semiconductor layer, and a gate quantum barrier between the first and second active layers.
US08421071B2 Memory device
A memory device in which a write error can be prevented is provided. The memory device includes a NAND cell unit including a plurality of memory cells connected in series, a first selection transistor connected to one of terminals of the NAND cell unit, a second selection transistor connected to the other of the terminals of the NAND cell unit, a source line connected to the first selection transistor, and a bit line which intersects with the source line and is connected to the second selection transistor. In the memory device, a channel region of each of the first selection transistor and the second selection transistor is formed in an oxide semiconductor layer.
US08421070B2 ZnO based semiconductor devices and methods of manufacturing the same
A semiconductor device may include a composite represented by Formula 1 below as an active layer. x(Ga2O3).y(In2O3).z(ZnO)  Formula 1 wherein, about 0.75≦x/z≦about 3.15, and about 0.55≦y/z≦about 1.70. Switching characteristics of displays and driving characteristics of driving transistors may be improved by adjusting the amounts of a gallium (Ga) oxide and an indium (In) oxide mixed with a zinc (Zn) oxide and improving optical sensitivity.
US08421069B2 Semiconductor device
An object is to reduce leakage current and parasitic capacitance of a transistor used for an LSI, a CPU, or a memory. A semiconductor integrated circuit included in an LSI, a CPU, or a memory is manufactured using the transistor which is formed using an oxide semiconductor which is an intrinsic or substantially intrinsic semiconductor obtained by removal of impurities which serve as electron donors (donors) from the oxide semiconductor and has larger energy gap than a silicon semiconductor, and is formed over a semiconductor substrate. With the transistor which is formed over the semiconductor substrate and includes the highly purified oxide semiconductor layer with sufficiently reduced hydrogen concentration, a semiconductor device whose power consumption due to leakage current is low can be realized.
US08421065B2 Organic electroluminescent display device
An organic electroluminescent display device which satisfies all of chromatic purity, transmission factor, reduction in reflection, and reflected color in balance at low cost is provided. An organic electroluminescent (EL) display device includes: a main substrate; an organic light-emitting layer formed above the main substrate and including a red light-emitting layer which emits red light, a green light-emitting layer which emits green light, a blue light-emitting layer which emits blue light, and a bank which is a non-light emitting region; a first light-adjusting layer formed above the blue light-emitting layer and the bank, which selectively transmits the blue light and selectively absorbs the green light and the red light; and a second light-adjusting layer formed above the red light-emitting layer and the green light-emitting layer, which selectively absorbs the blue light and selectively transmits the green light and the red light.
US08421063B2 Organic light emitting display
The general inventive concept relates to an organic light emitting display that has the same area where the upper and lower electrodes of a capacitor are overlapped for adjacent pixels, for respective pixels that constitute the organic light emitting display but implements the sizes of the upper and lower electrodes to be different. This thereby prevents the display quality of horizontal line shaped spot generated due to the effects of a critical dimension (CD) distribution from being degraded.
US08421062B2 Nanofiber composite, method of manufacturing the same, and field effect transistor including the same
A nanofiber composite including a nanofiber formed of a hydrophobic polymer, a nanowire formed of a conductive or semiconductive organic material that is oriented in the nanofiber in the longitudinal direction of the nanofiber, and an ionic active material.
US08421060B2 Reconfigurable logic device using spin accumulation and diffusion
A logic device includes: a substrate having a channel layer; two input terminal patterns of ferromagnetic material formed on the substrate and spaced apart from each other along a longitudinal direction of the channel layer so as to serve as the input terminals of a logic gate; and an output terminal pattern of ferromagnetic material formed on the substrate and disposed between the two input terminal patterns to serve as an output terminal of the logic gate. The output terminal pattern reads an output voltage by using spin accumulation and diffusion of electron spins which are injected into the channel layer from the input terminal patterns.
US08421059B2 Strain-inducing semiconductor regions
A method to form a strain-inducing semiconductor region is described. In one embodiment, formation of a strain-inducing semiconductor region laterally adjacent to a crystalline substrate results in a uniaxial strain imparted to the crystalline substrate, providing a strained crystalline substrate. In another embodiment, a semiconductor region with a crystalline lattice of one or more species of charge-neutral lattice-forming atoms imparts a strain to a crystalline substrate, wherein the lattice constant of the semiconductor region is different from that of the crystalline substrate, and wherein all species of charge-neutral lattice-forming atoms of the semiconductor region are contained in the crystalline substrate.
US08421056B2 Light-emitting device epitaxial wafer and light-emitting device
A light-emitting device epitaxial wafer includes an n-type substrate, an n-type cladding layer stacked on the n-type substrate, a light-emitting layer including a quantum well structure stacked on the n-type cladding layer, and a p-type cladding layer stacked on the light-emitting layer. The n-type cladding layer includes an epitaxial layer doped with a mixture of 2 or more n-type dopants including Si, and is not less than 250 nm and not more than 750 nm in thickness. Alternatively, a light-emitting device epitaxial wafer includes an n-type substrate, an n-type cladding layer stacked on the n-type substrate, a light-emitting layer stacked on the n-type cladding layer, and a p-type cladding layer stacked on the light-emitting layer. The n-type cladding layer includes 2 or more n-type impurities including Si.
US08421054B2 Light-emitting diode
A light-emitting diode element includes: an n-type conductive layer 2 being made of a gallium nitride-based compound, a principal surface being an m-plane; a semiconductor multilayer structure 21 provided on a first region 2a of the principal surface of the n-type conductive layer 2, the semiconductor multilayer structure 21 including a p-type conductive layer 4 and an active layer 3; a p-electrode 5 provided on the p-type conductive layer 4; a conductor portion 9 provided on a second region 2b of the principal surface of the n-type conductive layer 2, the conductor portion 9 being in contact with an inner wall of a through hole 8; and an n-type front surface electrode 6 provided on the second region 2b of the principal surface of the n-type conductive layer 2, the n-type front surface electrode 6 being in contact with the conductor portion 9.
US08421048B2 Non-volatile memory with active ionic interface region
An example memory cell may have at least a tunneling region disposed between a conducting region and a metal region, wherein the tunneling region can have at least an active interface region disposed between a first tunneling barrier and a second tunneling barrier. A high resistive film is formed in the active interface region with migration of ions from both the metal and conducting regions responsive to a write current to program the memory cell to a selected resistive state.
US08421047B2 Electro-hydrodynamic wind energy system
A system for electro-hydrodynamically extracting energy from wind includes an upstream collector that is biased at an electric potential and induces an electric field. An injector introduces a particle into the electric field. The wind drag on the particle is at least partially opposed by a force of the electric field on the particle. A sensor monitors an ambient atmospheric condition, and a controller changes a parameter of the injector in response to a change in the atmospheric condition.
US08421044B2 Radiation shielding lid for an auxiliary shield assembly of a radioisoptope elution system
Disclosed herein are embodiments of a radiation shielding lid of a radiation shielding container (e.g., auxiliary radiation shield) designed to house a radioisotope generator assembly.
US08421041B2 Intensity control of a charged particle beam extracted from a synchrotron
The invention comprises intensity control of a charged particle beam acceleration, extraction, and/or targeting method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Particularly, intensity of a charged particle stream of a synchrotron is described. Intensity control is described in combination with turning magnets, edge focusing magnets, concentrating magnetic field magnets, winding and control coils, and extraction elements of the synchrotron. The system reduces the overall size of the synchrotron, provides a tightly controlled proton beam, directly reduces the size of required magnetic fields, directly reduces required operating power, and allows continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.
US08421040B2 Writing apparatus and writing method
A writing apparatus includes a writing unit configured to write a first pattern onto a first mask substrate and a second pattern being complementary to the first pattern onto a second mask substrate using a charged particle beam, and an addition unit configured to add a positional deviation amount of the first pattern having been written on the first mask substrate to a writing position of the second pattern, wherein the writing unit writes the second pattern at the writing position on the second mask substrate, where the positional deviation amount of the first pattern has been added.
US08421038B2 Methods and systems for protecting critical structures during radiation treatment
Methods and systems are provided for protecting a critical structure during the administration of radiation treatment to a patient. A register receives proposed positions for one or more radiation beams with respect to a critical structure. A processor predicts a cumulative dose volume for the critical structure based on the dose distribution, and determines if the cumulative dose volume exceeds a tolerance value. If the cumulative dose volume exceeds the tolerance value, the dose distribution may be translated at least in part based on a relationship between the cumulative dose volume and the dose distribution position.
US08421036B2 Optical signal detection method, apparatus, sample cell and kit
A sensor chip includes a dielectric plate and a sensor portion having a metal layer deposited on a predetermined area on the dielectric plate. A photo-reactable labeling-substance of an amount corresponding to the amount of a substance to be detected in a sample binds to the sensor portion by contacting the sample with the sensor portion. The amount of the substance to be detected is obtained by irradiating the predetermined area with excitation light and by detecting light output from the photo-reactable labeling-substance in an enhanced electric field that has been generated on the metal layer by irradiation with the excitation light. The photo-reactable labeling-substance includes a photo-reactable substance enclosed by a light transmissive material that transmits light output from the photo-reactable substance to prevent metal quenching that occurs when the photo-reactable substance is located close to the metal layer.
US08421035B2 High-resolution microscope using optical amplification
Systems and methods that enhance the resolution of a microscope in all three spatial dimensions. A microscope system is provided that typically includes a first objective lens (20), an illumination source that provides excitation illumination (λex) at a first wavelength through the objective lens (20) in a first direction onto a fluorescent sample so as to induce fluorescent emission in the sample at a second wavelength (λfl) different than the first wavelength. The system also typically includes an element (60) that provides illumination at the second wavelength (λfl) to the sample in a second direction different from the first direction, and a detector (10) for detecting the fluorescent emission. The optical gain of the fluorescent emission at the second wavelength is enhanced through stimulated emission.
US08421034B2 Fluoroscopy apparatus and fluorescence image processing method
Provided is a fluoroscopy apparatus comprising a white-light-image generating section that generates a white-light image of observation target, a fluorescence-image generating section that generates a fluorescence image of the observation target, a fluorescence-image correcting section that normalizes the fluorescence image with the white-light image, a displacement calculating section that calculates the displacement of the observation target from a plurality of white-light images generated at time intervals, a region-size calculating section that calculates the size of a region having a fluorescence intensity higher than or equal to a predetermined threshold value from the fluorescence image, and a control unit that controls the fluorescence-image correcting section so that, when the displacement of the observation target relative to the size of the region is larger than or equal to a predetermined proportion, normalization of the fluorescence image is stopped.
US08421031B2 Particle beam therapy system
The objective is to obtain a particle beam therapy system that can suppress the effect of a leakage dose. There are provided a scanning nozzle that irradiates in a predetermined direction a particle beam emitted from an accelerator; an irradiation control unit that controls operation of the irradiation nozzle in such a way that the particle beam of a predetermined dose is sequentially irradiated onto each of a plurality of spots set in a planar direction in an irradiation subject; and a control unit that on/off-controls emission of the particle beam from the accelerator. The irradiation control unit makes the irradiation nozzle scan in a diluting manner the particle beam onto a predetermined area in the irradiation subject, in a predetermined period after a time point when emission is switched from ON to OFF, or in a period from the time point when emission is switched from ON to OFF to a time point when the particle beam is cut off.
US08421028B2 Device for deflecting or guiding in a particle beam
A device for deflecting a particle beam out of a beam axis, or for guiding a particle beam into the beam axis, has a simple design, requires little space, and additionally ensures that no area of an object that is not to be struck is struck by a particle beam. The device may include components in the following sequence along the beam axis: first deflection element, a magnetic apparatus for providing a magnetic field axially to the beam axis, and a second deflection element. A particle beam apparatus may have a device of this type.
US08421027B2 Charged particle analyser and method using electrostatic filter grids to filter charged particles
A charged particle analyzer (1) comprises a first non-imaging electrostatic lens (8, 9) for receiving charged particles having divergent, trajectories and for converting the said trajectories into substantially parallel trajectories. At least one planar filter (10) is provided for receiving the charged particles having the substantially parallel trajectories and for filtering the charged particles in accordance with their respective energies. A second non-imaging electrostatic lens (11) receives the energy filtered charged particles and selectively modifies their trajectories as a function of their energies. A charged particle detector (12) then receives the charged particles in accordance with their selectively modified trajectories.
US08421022B2 Method and apparatus for tissue equivalent solid state microdosimetry
A microdosimeter, comprising an array of three-dimensional p-n junction semiconductor detectors, each providing a sensitive volume-target and a tissue equivalent medium for generating secondary charged particles. The array is manufactured from a semiconductor on insulator wafer and the detectors are located to detect secondary charged particles generated in the tissue equivalent medium.
US08421009B2 Test structure for charged particle beam inspection and method for defect determination using the same
A test structure and method thereof for determining a defect in a sample of semiconductor device includes at least one transistor rendered grounded. The grounded transistor is preferably located at at least one end of a test pattern designed to be included in the sample. When the test structure is inspected by charged particle beam inspection, the voltage contrast (VC) of the transistors in the test pattern including the grounded transistor is observed for determination of the presence of defect in the sample.
US08421008B2 Pattern check device and pattern check method
Provided is a pattern inspection apparatus including: a charge formation means which forms charge on a surface of a substrate (7) by generating an electron beam from a second electron source (20) which is different from an electron source (1) which generates an electron beam before irradiating an electron beam (3), a current measuring means (34) which measures a value of current flowing in the substrate while the charge is formed on the surface of the substrate by the charge formation means; and an adjustment means (37) which adjusts the charge formed by the charge formation means so that the value of the current measured by the current measuring means is a predetermined target value. Provided is also a pattern inspection method which uses the pattern inspection apparatus. Thus, it is possible to easily set an optimal condition of precharge executed before inspection of a pattern formed by a semiconductor apparatus manufacturing process and automatically inspection whether the precharge is good. Then, the inspection result is fed back to the operation afterward. This prevents lowering of the reliability of the inspection result and always enables a stable inspection.
US08421000B2 Beam shaping without introducing divergence within a light beam
An optical beam shaper comprises a polarization-dependent phase adjustment member which applies a phase pattern of equal magnitude and opposite sign to two orthogonal polarization states. In a preferred embodiment the beamer shaper is a dif tractive element made of a birefringent material, such as a photo-polymerizable liquid crystal polymer frozen in a uniaxial alignment, said dif tractive element comprising a plurality of zones, each zone having a stepped thickness defining a plurality of steps. The beam shaper can be used to introduce astigmatism to a polarized light beam or to undo the astigmatism to a beam with an orthogonal polarization state. The beam shaper is advantageously used within a detection device, such as a fluorescence scanner.
US08420998B2 Target detecting and determining method for detecting and determining target based on height information and storage medium for storing program executing target detecting and determining method
In a target detecting technique using a laser sensor, misdetection can be reduced while maintaining a wide detecting range. A target detecting method for detecting a target by emitting a laser beam diagonally downward from an installing position of a laser emitting and receiving portion. The method includes the steps of: obtaining distance information from the laser emitting and receiving portion to an object to be detected; determining, when the object to be detected approaches the laser emitting and receiving portion, whether the tracking of the object to be detected is stopped or not; and determining, when the tracking of the object to be detected is stopped, whether the object to be detected is the target or a non-target based on distance information immediately before the tracking of the object to be detected is stopped.
US08420992B2 Microscope
In microscopes, particularly laser scanning microscopes, for detecting light coming from a sample, it is known to protect detectors from excessively high light outputs by means of shutters in the detection beam path. Further, in order to measure the light output impinging on the detector when the detection beam path is closed, a portion of the light is coupled out of the detection beam path and directed to a monitor diode. Constructions of this kind are complicated and costly. In the microscope according to the invention, a monitor diode is arranged on the shutter in such a way that the monitor diode is situated in the detection beam path when the shutter is closed. This makes it possible in a simple manner to measure the light output in a microscope when the detection beam path is closed even without additionally coupling light out of the detection beam path.
US08420989B2 Coil and semiconductor apparatus having the same
An apparatus to package a semiconductor chip includes a coil configured to use induction heating to reflow a solder ball of the semiconductor chip. The coil includes a first body, a second body parallel to the first body, a third body extending from the first body to the second body. The first and second bodies are symmetrical with respect to a vertical plane disposed therebetween. The first and second bodies have inclined surfaces facing each other, and the inclined surfaces are distant from each other downward.
US08420988B2 Cooktop control panel mounting assembly
A domestic appliance includes a control panel and a control panel mounting bracket which includes a frame shaped for being installed on a surface panel of a domestic appliance. The surface panel has an opening therein for receiving the frame. The frame has an open portion for receiving a control mount adhered over the open portion. The surface panel has a top surface and a bottom surface, and the frame has a main securing member having at least one tab extending therefrom. The tab is bendable along a line off-set from vertical such that when the tab is bent, it bears against the bottom surface of the surface panel to urge the frame against the surface panel.
US08420985B2 Mirror and window de-fogging device
The de-fogging device and has an elongated heating element mounted within a housing. There is an elongated opening in the housing beneath the heating element for admission of air below the device and a second elongated opening in the housing above the heating element through which air heated by the heating element flows by convection. The device is mounted to a mirror or window and is positioned such that the heated air flows upwardly across the mirror or window. There is means for regulating the temperature of the heating element such that the heated air prevents any moisture in the air surrounding the mirror or window from condensing on it.
US08420980B2 Ceramic heater, oxygen sensor and hair iron that uses the ceramic heater
The conventional lead member had a constant thickness in a section parallel to a longitudinal direction, so that it has found it difficult to enlarge a joint area with a soldering material. Therefore, the lead member itself has to be enlarged so as to enlarge the contact area which contributes to the joining property between the lead member and the soldering material. In a section parallel to the longitudinal direction of a lead member (11) and containing the center axis (A) of the lead member (11), the distance from one point (X) of the soldered portion of the outer circumference of the lead member (11) to the center axis (A) of the lead member (11) is made shorter than the distance from another point (Y) of the soldered portion to the center axis (A), so that the contact area between the lead member (11) and the soldering material can be enlarged.
US08420978B2 High throughput, low cost dual-mode patterning method for large area substrates
A high-throughput, low cost, patterning platform is provided that is an alternative to conventional photolithography and direct laser ablation patterning techniques. The processing methods are useful for making patterns of microsized and/or nanosized structures having accurately selected physical dimensions and spatial orientation that comprise active and passive components of a range of microelectronic devices. Processing provided by the methods is compatible with large area substrates, such as device substrates for semiconductor integrated circuits, displays, and microelectronic device arrays and systems, and is useful for fabrication applications requiring patterning of layered materials, such as patterning thin film layers in thin film electronic devices.
US08420977B2 High power laser system
A modulation device for directing a mobile tracking device away from an asset is provided. The modulation device includes a continuous wave laser source whose output is directed at a seeker head of the mobile tracking device. The modulation device causes the generation of localized sources within the mobile tracking device and confuses the mobile tracking device as to the true location of the asset. A portable cutting device is disclosed. The portable cutting device may include a portable power supply and a laser source. The portable power supply and laser source of the portable cutting device may be positioned within a backpack and carried by a user. A handheld unit which is coupled to the laser source may be supported by the hands of the operator. The handheld unit provides power generated by the laser source to a barrier to be cut.
US08420976B2 Laser welder
An apparatus for fitting two first workpieces with respective second workpieces of different dimensions has a track extending longitudinally through an assembly station and a welding station. An assembling appliance in the assembly station has a pair of jigs each dimensioned to fit with a respective one of the second workpieces, and a holdown appliance in the welding station similarly has a pair of differently sized holddowns. The holddown appliance can move between a pair of positions in each of which a respective one of the holddowns is aligned under the welding head. A workpiece holder in which either of the first workpieces can be held is shiftable between positions in the assembly station under the assembling appliances and a position in the welding station underneath a stationary welding head therein.
US08420974B2 Long life welding electrode and its fixing structure, welding head, and welding method
A fixing structure for a welding electrode and a welding head is shown which enable improvement of durability of a welding electrode, improvement of work efficiency in welding, and a reduction of time required for welding and also which make it possible to execute welding for an extended time with high reliability. In the fixing structure, a fixed section of a welding electrode is inserted via a thermally conductive material into an inserting section of a fixing base and a peripheral surface of the fixed section of the welding electrode is uniformly contacted to the fixing base to affix the welding electrode to the fixing base.
US08420970B2 Touch panel
A touch panel includes a substrate, plural first bridges, an insulating layer, plural conductive columns, plural second bridges, plural first sensing pads, plural second sensing pads, a reticulated electrode, and plural discharge electrodes. The insulating layer disposed on the substrate covers the first bridges and the substrate. The conductive columns are connected between the first sensing pads and the first bridges. The second bridges, the first sensing pads, the second sensing pads, the reticulated electrode, and the discharge electrodes are disposed on the insulating layer. Each of the second bridges is connected between two adjacent second sensing pads. The first sensing pads and the second sensing pads are located in openings of the reticulated electrode respectively and electrically insulated from the reticulated electrode. Each of the discharge electrodes connected to the reticulated electrode is located between two adjacent first sensing pads and between two adjacent second sensing pads.
US08420967B2 Back-lit operating unit for construction machinery
A back-lit operating unit for construction machinery includes a front panel having a plurality of cut-outs. Operating components are received in the cut-outs. A lighting device is arranged behind the front panel. The front panel has a sandwich construction including a carrier panel, a transparent mounting panel located on a front of the carrier panel, and a transparent film located on a front of the mounting panel.
US08420964B2 Electrical apparatus, and racking assembly and coupling therefor
A coupling is for a racking assembly for racking an electrical apparatus into and out of an enclosure with an actuator. The electrical apparatus includes a housing. The racking assembly includes a safety interlock, which is movable between a locked position, and an unlocked position corresponding to the racking assembly being operable to rack the electrical apparatus into or out of the enclosure. The coupling includes an adapter having a first portion coupled to the racking assembly, and a second portion coupled to the actuator. A sleeve is movably disposed on the adapter. The sleeve moves the safety interlock from the locked position to the unlocked position. When the safety interlock is disposed in the unlocked position, the adapter transfers movement of the actuator to the racking assembly to move the electrical apparatus.
US08420961B2 Contact block with interlock
An interlock contact block providing an automatic electrical disconnect for pushbutton operated contact blocks when components of the pushbutton switch assembly become sufficiently loose or dislodged from one another that proper operation of one or more contact blocks associated with the switch assembly can not be operated by the pushbutton assembly.
US08420956B2 Electrical device mounting adapter
In one embodiment, an adapter may include first and second mounting portions adapted to be attached to first and second mounting portions of an electrical device, and first and second spacers arranged to space the first and second mounting portion of the electrical device away from a building surface when the electrical device is mounted to an electrical box. In another embodiment, an adapter may include a ring to surround a body of a standard electrical device, and first and second slots to receive first and second mounting portion of the standard electrical device.
US08420955B2 Lead pin for package substrate
A lead pin for a package substrate includes a coupling pin, a head portion, and a flowing prevention portion. The coupling pin is to be inserted into a hole which is formed in an external substrate. The head portion is formed at one end of the coupling pin. The flowing prevention portion is formed on the top surface of the head portion and prevents a solder paste from flowing toward the coupling pin on the top surface of the head portion when the head portion is mounted on the package substrate.
US08420951B2 Package structure
A manufacturing method of a package structure is provided. In the manufacturing method, a metal substrate having a seed layer is provided. A patterned circuit layer is formed on a portion of the seed layer. A first patterned dry film layer is formed on the other portion of the seed layer. A surface treatment layer is electroplated on the patterned circuit layer with use of the first patterned dry film layer as an electroplating mask. The first patterned dry film layer is removed. A chip bonding process is performed to electrically connect a chip to the surface treatment layer. An encapsulant is formed on the metal substrate. The encapsulant encapsulates the chip, the surface treatment layer, and the patterned circuit layer. The metal substrate and the seed layer are removed to expose a bottom surface of the encapsulant and a lower surface of the patterned circuit layer.
US08420950B2 Circuit system with leads and method of manufacture thereof
A method of manufacture of a circuit system includes: providing a carrier base; forming a cavity in the carrier base; forming a bridge lead over the cavity, the bridge lead exposing the cavity; and mounting a device having an anchor interconnect, the anchor interconnect is in the cavity and conformal to the bridge lead over the cavity.
US08420947B2 Integrated circuit system with ultra-low k dielectric and method of manufacture thereof
A method of manufacturing an integrated circuit system includes: providing a etch stop layer; forming a layer stack over the etch stop layer with the layer stack having an anti-reflective coating layer over a low temperature oxide layer; forming a photoresist layer over the anti-reflective coating layer; forming a first resist line and a second resist line from the photoresist layer with the first resist line and the second resist line separated by a through line pitch on the anti-reflective coating layer; etching the anti-reflective coating layer using a low-pressure polymer burst with a non-oxidizing gas mixture to remove a portion of the anti-reflective coating layer; and forming a first polymer layer over the first resist line.
US08420941B2 Conductive channel of photovoltaic panel and method for manufacturing the same
An electrically conductive ribbon, which is soldered on an electrically conductive busbar of a photovoltaic panel, includes a cooper core and a tin based solder. The tin based solder fully wraps an outer surface of the cooper core, and has a convex solder surface, which has a first curvature to be fitted with a second curvature of a concave solder surface of the electrically conductive busbar.
US08420937B2 Enclosure of outdoor apparatus
An enclosure of an outdoor apparatus includes a first case, a second case and a gasket ring sealed between the first case and the second case. The first case includes a first cover and a flange portion extending from the first cover outwardly. The first case defines a first open surrounded by the flange portion. The flange portion defines a latching groove towards the first open. The second case includes a second cover and a stopper portion extending from the second cover outwardly. The stopper portion is received in the first open and matches with the flange portion. The cover defines a second open surrounded by the stopper portion and opposite to the first open. The stopper portion includes a latch portion protruded outwardly from the stopper portion to engage with the latching groove.
US08420935B2 Bus support system for a motor control center
A bus support system is provided. The bus support system includes a bus support having a plurality of vertical channels configured to receive vertical bus conductors, each of the plurality of vertical channels having a rear protrusion on a rear side of the bus support. The bus support system also includes a plurality of add-on bus support braces disposed on the rear side of the bus support and configured to contact the plurality of channels to limit a movement of the vertical bus conductors during a high current event.
US08420931B2 Electrical junction box
An electrical junction box includes a junction-box body having at least an outlet for discharging a liquid inside thereof to an outside thereof; and a bracket provided between the junction-box body and a vehicle-body panel. The bracket is adapted to attach the junction-box body to the vehicle-body panel such that the bracket resides in a lower space relative to the junction-box body in a vertical direction. The bracket includes a throughhole communicating with the outlet and adapted to guide the liquid from the outlet to the outside. The bracket may include a plurality of ribs spaced from each other and upstanding in a shape of a plate toward the vehicle-body panel such that the outlet is provided between the ribs. The ribs may be connected to each other via a foot of the bracket upstanding in a shape of a plate toward the vehicle-body panel.
US08420930B2 Method for making a protective element for items and casing obtained by said method
The purpose of the disclosure is to provide an insulation structure for efficiently controlling a thermal flow and protecting objects that is easy to implement, has a low cost and is compliant with strict standards in terms of fire resistance while offering protection against crushing and immersion. Accordingly the disclosure relates to a method for protecting at least one object previously encapsulated in a sealed pocket, that comprises imbedding the objects without trapping any air in a body of a high thermal-resistance insulator containing gypsum crystals, said insulator body being cast in a structure having a high mechanical resistance to crushing, and said structure consisting of an intermediate mould or directly defining a housing. A casing obtained by said method comprises the body block of a high thermal-resistance insulator and the housing having a high mechanical resistance to crushing. Advantageously, the objects, such as an electronic board, are encapsulated in a silicone sealed pocket, and the housing includes steam discharge slots as well as an opening for casting the insulator body, said opening being then closed by a plate held on the housing by screws. Sealed ducts are provided in the plate, the insulator, and the pocket for passing electric wires therethrough.
US08420921B2 Information processing apparatus, sound analysis method, and program
An information processing apparatus is provided which includes a beat analysis unit for detecting positions of beats included in an audio signal, a structure analysis unit for calculating similarity probabilities, each being a probability of similarity between contents of sound of beat sections divided by each beat position detected by the beat analysis unit, and a bar detection unit for determining a likely bar progression of the audio signal based on bar probabilities determined according to the similarity probabilities calculated by the structure analysis unit, the bar probabilities indicating to which ordinal in which meter respective beats correspond.
US08420920B2 Fret removal tool
A hand tool for removing frets associated with guitars, banjos and other string instruments. The tool has a handle with a blade extending therefrom. At a distal end of the blade is a slot wider than a tang of a fret and smaller than a top of the fret. The tool is slid under the fret, thereby providing pressure both to raise the fret and at the same time also against the wood surrounding the tang to prevent undue breakage of the wood during removal of the fret.
US08420918B2 Pedal device, and electronic musical instrument including the pedal device
Pedal device for an electronic keyboard instrument includes a pedal having opposed side walls extending downward from the opposite side edges, in a width direction, of an upper wall, and a reactive force imparting member which imparts reactive force to the pedal by being pressed by the lower surface of the pedal. The reactive force imparting member includes a plate-shaped base portion mounted on a mounting portion of a support member, and an upwardly-convexed dome-shaped body portion integrally formed with the upper surface of the base portion. The body portion and mounting portion each have a width dimension smaller than a distance between the opposed side walls of the pedal so that, during stroke action of the pedal, the body portion and mounting portion falls within a space between the opposed side walls.
US08420915B1 Inbred corn line NPXO5745GT21
Basically, this invention provides for an inbred corn line designated NPXO5745GT21, methods for producing a corn plant by crossing plants of the inbred line NPXO5745GT21, with plants of another corn plant. The invention relates to the various parts of inbred NPXO5745GT21, including culturable cells. This invention also relates to methods for introducing transgenic transgenes into inbred corn line NPXO5745GT21, and plants produced by these methods.
US08420914B1 Inbred corn line NPIJ7011Bt11/CRW604
Basically, this invention provides for an inbred corn line designated NPIJ7011BT11/CRW604, methods for producing a corn plant by crossing plants of the inbred line NPIJ7011BT11/CRW604, with plants of another corn plant. The invention relates to the various parts of inbred NPIJ7011BT11/CRW604, including culturable cells. This invention also relates to methods for introducing transgenic transgenes into inbred corn line NPIJ7011BT11/CRW604, and plants produced by these methods.
US08420913B1 Inbred corn line NPID5198BT11/CRW604
Basically, this invention provides for an inbred corn line designated NPID5198BT11/CRW604, methods for producing a corn plant by crossing plants of the inbred line NPID5198BT11/CRW604, with plants of another corn plant. The invention relates to the various parts of inbred NPID5198BT11/CRW604, including culturable cells. This invention also relates to methods for introducing transgenic transgenes into inbred corn line NPID5198BT11/CRW604, and plants produced by these methods.
US08420906B2 Inbred sorghum line ‘R07007’
An inbred sorghum line, designated R07007, is disclosed. The invention relates to the seeds of inbred sorghum line R07007, to the plants of inbred sorghum line R07007 and to methods for producing a sorghum plant by crossing the inbred line R07007 with itself or another sorghum line. The invention further relates to hybrid sorghum seeds and plants produced by crossing the inbred line R07007 with another sorghum line. The invention further relates to methods for producing a sorghum plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other inbred sorghum lines derived from the inbred R07007.
US08420904B1 Soybean cultivar WN0810485
The present invention is in the field of soybean variety WN0810485 breeding and development. The present invention particularly relates to the soybean variety WN0810485 and its progeny, and methods of making WN0810485.
US08420902B2 Soybean variety A1024640
The invention relates to the soybean variety designated A1024640. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1024640. Also provided by the invention are tissue cultures of the soybean variety A1024640 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1024640 with itself or another soybean variety and plants produced by such methods.
US08420901B2 Soybean variety A1024627
The invention relates to the soybean variety designated A1024627. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1024627. Also provided by the invention are tissue cultures of the soybean variety A1024627 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1024627 with itself or another soybean variety and plants produced by such methods.
US08420899B2 Soybean variety A1023692
The invention relates to the soybean variety designated A1023692. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1023692. Also provided by the invention are tissue cultures of the soybean variety A1023692 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1023692 with itself or another soybean variety and plants produced by such methods.
US08420898B2 Soybean variety A1024210
The invention relates to the soybean variety designated A1024210. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1024210. Also provided by the invention are tissue cultures of the soybean variety A1024210 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1024210 with itself or another soybean variety and plants produced by such methods.
US08420894B2 Snap pea variety SL3118
A novel snap pea cultivar, designated SL3118, is disclosed. The invention relates to the seeds of pea cultivar SL3118, to the plants of pea-line SL3118 and to methods for producing a pea plant by crossing the cultivar SL3118 with itself or another pea line. The invention further relates to methods for producing a pea plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other pea lines derived from the cultivar SL3118.
US08420893B2 AP2 domain transcription factor ODP2 (ovule development protein 2) and methods of use
Methods and compositions for modulating plant development are provided. Nucleotide sequences and amino acid sequences encoding Ovule Development Protein 2 (ODP2) proteins are provided. The sequences can be used in a variety of methods including modulating development, developmental pathways, altering oil content in a plant, increasing transformation efficiencies, modulating stress tolerance, and modulating the regenerative capacity of a plant. Transformed plants, plant cells, tissues, and seed are also provided.
US08420890B2 Use of NAP gene to manipulate leaf senescence in plants
The present invention discloses transgenic plants having an altered level of NAP protein compared to that of a non-transgenic plant, where the transgenic plants display an altered leaf senescence phenotype relative to a non-transgenic plant, as well as mutant plants comprising an inactivated NAP gene, where mutant plants display a delayed leaf senescence phenotype compared to that of a non-mutant plant. The present invention also discloses methods for delaying leaf senescence in a plant, as well as methods of making a mutant plant having a decreased level of NAP protein compared to that of a non-mutant plant, where the mutant plant displays a delayed leaf senescence phenotype relative to a non-mutant plant. Methods for causing precocious leaf senescence or promoting leaf senescence in a plant are also disclosed. Also disclosed are methods of identifying a candidate plant suitable for breeding that displays a delayed leaf senescence and/or enhanced yield phenotype.
US08420887B2 Plants having improved growth characteristics and method for making the same
The present invention concerns a method for improving growth characteristics of plants by increasing expression and/or activity in a plant of an LRR receptor kinase or a homologue thereof. One such method comprises introducing into a plant an RLK827 nucleic acid molecule or functional variant thereof. The invention also relates to transgenic plants having improved growth characteristics, which plants have modulated expression of a nucleic acid encoding an LRR receptor kinase. The present invention also concerns constructs useful in the methods of the invention.
US08420885B2 Determining the capability of a test compound to affect solid tumor stem cells
A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumor cells in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells. We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.
US08420880B2 Removal equipment and method for the storage facility for transuranium compounds
A nuclear chemistry laboratory adopts In-site Cutting Technique to remove the large-scale glove box contaminated by transuranium compounds. During removal operation, to prevent further spreading of contamination, it is necessary to build an alpha airtight quarantine tent around the glove box that is ready to be cut. Each section of the quarantine tent maintains a stable airflow and sufficient air exchange to meet negative pressure requirements and effectively prevent leak of α contamination. It is necessary to install a negative pressure ventilation system to assure the operation of the quarantine tent that has a pressure gradient and allows airflow from low contamination area to high contamination area to effectively prevent spreading of α contamination and also increase the safety for the transuranium contaminated glove box that is not in service.
US08420871B2 Process for producing an organic compound
Process for producing a chlorohydrin by reaction between a multihydroxylated-aliphatic hydrocarbon, an ester of a multihydroxylated-aliphatic hydrocarbon, or a mixture thereof, and a chlorinating agent, according to which the multihydroxylated-aliphatic hydrocarbon, the ester of a multihydroxylated-aliphatic hydrocarbon, or the mixture thereof used contains at least one solid or dissolved metal salt, the process comprising a separation operation to remove at least part of the metal salt.
US08420870B2 Process and apparatus for recovery of dichlorohydrins via codistillation
A process and apparatus for recovering dichlorohydrins from a mixture comprising dichlorohydrins, one or more compounds selected from esters of dichlorohydrins, monochlorohydrins and/or esters thereof, and multihydroxylated-aliphatic hydrocarbon compounds and/or esters thereof, and optionally one or more substances comprising water, chlorinating agents, catalysts and/or esters of catalysts is disclosed. The mixture is stripped to recover dichlorohydrin(s) while distilling or fractionating the mixture to separate a lower boiling fraction comprising dichlorohydrin(s) from the mixture in one step. Advantages include more efficient recovery of dichlorohydrins for a given distillation column, less waste due to avoiding the conditions conducive to the formation of heavy byproducts, and reduced capital investment in recovery equipment.
US08420868B2 Process for the preparation of 2,2,4,4-tetraalkylcyclobutane-1,3-diols
Disclosed is a process for the preparation of a 2,2,4,4-tetraalkylcyclobutane-1,3-diols by hydrogenation of a 2,2,4,4-tetraalkylcyclobutane-1,3-dione in the presence of a catalyst comprising ruthenium deposited on a carbon nanotube support. The process is useful for the preparation of 2,2,4,4-tetramethylcyclobutane-1,3-diol. The process may be carried out in the presence or absence of a solvent and in the liquid or vapor phase. Also disclosed is a process for modifying the cis:trans ratio of the 2,2,4,4-tetramethylcyclobutane-1,3-diol hydrogenation product by contacting the diol with hydrogen in the presence of a supported ruthenium catalyst.
US08420866B2 Process for preparing ketones by reacting 1,1-disubstituted olefins with N2O
The present invention relates to a process for preparing a ketone, comprising the reaction of a composition (I) at least comprising a 1,1-disubstituted olefin, with a composition comprising dinitrogen monoxide, wherein the reaction is effected in the presence of a solvent which comprises at least one proton-donating functional group.
US08420862B2 Process for the preparation of highly pure monomers for polybenzimidazole materials
Highly pure 2,3,5,6-tetraaminotoluene species are produced by chemically reducing undesirable oxidation byproducts. The 2,3,5,6-tetraaminotoluene species are then used in the manufacture of superior high-performance polybenzimidazole polymers.
US08420855B2 Insecticidal compounds
A compound of formula (I), wherein A1, A2, A3, A4, R1, R2, G1, G2, Q1 and Q2 are as defined in claim 1; or salts or N-oxides thereof. Furthermore, the present invention relates to processes and intermediates for preparing compounds of formula (I), to insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control insect, acarine, mollusc and nematode pests.
US08420854B2 Di(meth)acrylate compound, polymerizable liquid crystal composition, optical anisotropic material, optical element and optical information writing/reading device
The present invention provides an optical anisotropic material having a good light stability, and provides a di(meth)acrylate compound represented by the following formula (1) and a polymerizable liquid crystalline composition that are suitable for the production of the optical anisotropic material. Further, the present invention provides an optical element having a good light stability and an optical information writing/reading device using the same.
US08420850B2 Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers
The invention comprises compounds which are derived from a drug or a substance with therapeutic properties, and useful as reagents for the synthesis of biostable polymers including said drug in their backbone, namely polyurethanes, polyureas or polyurea urethanes that are biocompatible and biostable. The invention also comprises the processes for preparing the compounds and the polymers, and to the use of these polymers for the manufacture of medical devices.
US08420849B2 Process for producing thiophene compound and intermediate thereof
Provided are γ-ketosulfide compounds represented by the formula (5): where the structural variables R1, R2, R3 and R4 are as defined herein.
US08420843B2 Fluoroalkyl carbinol generating silane surface treatment agents
The compound is a silane surface treatment agent and is useful for modifying the surfaces of silicon oxide and other metal oxides with hexafluorodimethyl carbinol functional groups. Additionally provided is a surface treatment procedure that effectively bonds it and other alkoxysilanes via homogeneous and heterogeneous amine catalysis onto metal oxide surfaces.
US08420842B2 Lanolin substitute, production method thereof and applications of same
This invention proposes a lanolin substitute, capable of absorbing up to at least twice its weight of water or aqueous solution or aqueous suspension. It forms true emulsions, stable over time with a capacity for water absorption superior to that of lanolin.It also possesses the known emollient, moisturizing and occlusive properties of lanolin.This substitute is usable in all the present and future areas of application of lanolin: in the cosmetics industry, dermatology, and in industrial applications (polishes, lubricants . . . ).It is obtained by hemi-synthesis from a mixture of unsaturated fatty acids, esters of unsaturated fatty acids, unsaturated hydrocarbons or unsaturated derivatives of the latter and compounds comprising or generating hydroxyl functions, such as glycerol, preferably without a catalyst and in an atmosphere devoid of oxygen.Classical thermal treatment or preferably treatment by dielectric heating.
US08420839B1 Crystallization of 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol
A method of purifying 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol to obtain 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol in crystalline form using precipitation with hexane from ethyl acetate. A method of preparing 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol crystals acceptable for X-ray experiment using precipitation with hexane from benzene by diffusive exchange of the solvents is also described.
US08420837B2 Method of preparing a nanoparticulate iron—crown ether complex
A stabilized nano-Fe6-iron-crown ether complex is formed by preparing a solution of an iron salt and an olygomer crown compound in dialkylamine or diethylamine. Sodium tetrahydroboron (NaBH4) and dialkylamine or ethylendiamine are added at a temperature of 0-10° C. The mixture is heated to room temperature and boiled, thereby converting the formed iron (II)-borhydride complex (Fe(BH4)2) to a crown ether—iron-hydride complex [CWFe06]·(2H)6. At higher temperature this last complex is converted to the Fe06-crown nanocomposite complex.
US08420836B2 NFAT signal inhibitor and hair-growing agent
An NFAT signal inhibitor and the like are provided.An NFAT signal inhibitor and the like, containing, as an active ingredient, at least one compound selected from the group consisting of a coumarin derivative represented by formula [where in the formula (I), R1 and R2, which may be identical with or different from each other, each represent a hydrogen atom or a group represented by formula (II) (where in the formula (II), R3 represents a linear or branched alkyl or alkenyl group having 1 to 20 carbon atoms)] and pharmacologically acceptable salts thereof.
US08420833B2 Producing biofuels using polyketide synthases
The present invention provides for a non-naturally occurring polyketide synthase (PKS) capable of synthesizing a carboxylic acid or a lactone, and a composition such that a carboxylic acid or lactone is included. The carboxylic acid or lactone, or derivative thereof, is useful as a biofuel. The present invention also provides for a recombinant nucleic acid or vector that encodes such a PKS, and host cells which also have such a recombinant nucleic acid or vector. The present invention also provides for a method of producing such carboxylic acids or lactones using such a PKS.
US08420831B2 Intermediates of 1-O-acyl-2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranoses
The present invention relates to a process for preparing 1-O-acyl-2-deoxy-2-fluoro-4-thio-β-D-arabinofuranoses having formula I and intermediates thereof: wherein R1 represents —C(O)—C1-C6-alkyl or —C(O)-aryl; and R2 represents C1-C6-alkyl, C1-C4-perfluoroalkyl or aryl.
US08420824B2 Substituted pyrazoles, compositions containing these, method of production and use
The disclosure relates to a compound of formula (I): and salts thereof; wherein Ar, L, A, X, R1, R2, R3, R4a, R4b, and R5 are as defined in the disclosure; compositions comprising said compounds, methods for their preparation, intermediates thereto, and the use thereof, particularly as drugs.
US08420823B2 Long-chain fatty acyl elongase inhibitor comprising arylsulfonyl derivative as active ingredient
[Problem] To provide compounds useful as preventives or remedies for circular system disorders, nervous system disorders, metabolic disorders, reproduction system disorders, digestive system disorders, neoplasm, infectious diseases, etc., or as herbicides.[Means for Solution] A long-chain fatty acyl elongase inhibitor comprising, as the active ingredient thereof, a compound or a pharmaceutically-active salt thereof of a formula (I): [wherein W represents a hydrogen atom, a C1-6 alkyl, etc.; X represents an aryl, a heteroaryl, etc.; n indicates 0 or 1; Z represents a hydrogen atom, a C1-6 alkyl, etc.; A1, A2, A3 and A4 each independently represent CH or N].
US08420821B2 Process for production of 4-oxoquinoline compound
The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, the present invention provides, for example, compounds represented by the formulas (6), (7-1), (7-2) and (8): wherein R is a fluorine atom or a methoxy group, R1 is a C1-C4 alkyl group, R2 is a hydroxyl-protecting group, and X2 is a halogen atom, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.
US08420820B2 Pyrrolopyridinylpyrimidin-2-ylamine derivatives
Compounds of the formula I in which X, R1, R2, R3, R4 and R6 have the meanings indicated in Claim 1, are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumours.
US08420817B2 Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof
The invention relates to tricyclic N-heteroaryl-carboxamide derivatives having the formula (I): Wherein A, P, W, Z1, Z2, Z3, Z4, Z5, Z6, Z7, Z8, R3 and R3′ are as described herein. The invention also relates to a method for preparing the same and to the therapeutic use thereof.
US08420816B2 Dihydropyrrolonaphthyridinone compounds as inhibitors of JAK
Disclosed are JAK inhibitors of formula I where G1, R1, R2, R3, R4, R5, R6, and R7 are defined in the specification. Also disclosed are pharmaceutical compositions, kits and articles of manufacture which contain the compounds, methods and materials for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions involving the immune system and inflammation, including rheumatoid arthritis, hematological malignancies, epithelial cancers (i.e., carcinomas), and other diseases, disorders or conditions associated with JAK.
US08420815B1 Anti-cancer agents based on N-acyl-2, 3-dihydro-1H-pyrrolo[2,3-b]quinoline derivatives and a method of making
The present disclosure relates to novel compounds that can be used as anti-cancer agents in the prostate cancer therapy. In particular, the invention relates to N-acyl derivatives of 2,3-dihydro-1H-pyrrolo[2,3-b]quinolines having the structural Formula (I), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof. The meaning of R1 is independently selected from H; C1-C6 Alkyl, cyclo-Alkyl or iso-Alkyl substituents; R2 is selected from C1-C6 Alkyl, cyclo-Alkyl or iso-Alkyl; substituted or non-substituted, fused or non-fused to substituted or non-substituted aromatic ring, aryl or heteroaryl groups. The invention also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.
US08420809B2 Process for the manufacturing of betamimetics
The present invention relates to a process for preparing betamimetics of formula 1, wherein n denotes 1 or 2; R1 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R2 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R3 denotes hydrogen, C1-4-alkyl, OH, halogen, O—C1-4-alkyl, O—C1-4-alkylene-COOH, O—C1-4-alkylene-COO—C1-4-alkyl.
US08420806B2 Process for the crystallisation of cefadroxil monohydrate
The present invention relates to a process for the preparation of cefadroxil in crystal form, comprising a) adding an aqueous solution of cefadroxil to a crystallization vessel and a titrant to keep a pH in the crystallization vessel of between 7 to 9; and b) lowering the pH in the crystallization vessel to a value of between 5 and 6.5 to obtain a suspension of the β-lactam compound in crystal form. The invention further relates to cefadroxil in crystal form obtainable by the process according to the present invention. The invention also relates to cefadroxil in crystal form with a CIE b value of below 12 when stored at a temperature of 25° C. for at least 1 month.
US08420805B2 Process for preparing prophyrin derivatives, such as protoprophyrin (IX) and synthesis intermediates
The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: R and R′ are as defined in claim 1, comprising: a step of condensation, in an acidic medium, between a dipyrromethane of formula (II): in which R′b is as defined above for (I), and a dipyrromethane of formula (III): in which R″ is as defined in claim 1, and also the compounds of formula (III).
US08420798B2 Method for producing nucleic acid probes
The present disclosure provides nucleic acid probes, as well as kits that include such probes. Methods for producing and using (for example in chromosomal in situ hybridization) the probes are also provided. Such probes in some examples are used to detect chromosomal abnormalities or the presence of a pathogen.
US08420795B2 Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof. The neuromodulatory agent has one or more of the following characteristics: it is capable of inducing remyelination; binding to neural tissue; promoting Ca++ signaling with oligodendrocytes; and promoting cellular proliferation of glial cells. Amino acid and DNA sequences of exemplary antibodies are disclosed. Methods are described for treating demyelinating diseases, and diseases of the central nervous system of humans and domestic animals, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, active fragments thereof and the like. The invention also extends to the use of human antibodies, fragments, peptide derivatives and like materials, and their use in diagnostic and therapeutic applications, including screening assays for the discovery of additional antibodies that bind to cells of the nervous system, particularly oligodendrocytes.
US08420794B2 Anti-influenza M2e antibody
Humanized recombinant and monoclonal antibodies specific for the ectodomain of the influenza virus M2 ion channel protein are disclosed. The antibodies of the invention have anti-viral activity and may be useful as anti-viral therapeutics and/or prophylactic/vaccine agents for inhibiting influenza virus replication and for treating individuals infected with influenza.
US08420791B2 Expression of FoxP3 by cancer cells
The present invention relates to the treatment, diagnosis, and prophylaxis of cancer based on the expression of foxp3.
US08420790B2 Efficient and scalable process for the manufacture of Fondaparinux sodium
The present invention relates to a process for the synthesis of the Factor Xa anticoagulent Fondaparinux and related compounds. The invention relates, in addition, to efficient and scalable processes for the synthesis of various intermediates useful in the synthesis of Fondaparinux and related compounds.
US08420788B2 Epitopes derived from SATB2 and uses thereof
The present invention relates to an affinity ligand capable of selective interaction with an epitope sequence consisting of 47 amino acids or less and comprising the amino acid sequence of SEQ ID NO:1 and/or SEQ ID NO:2. Further, it relates to a polypeptide consisting of the epitope sequence and to uses of the affinity ligand and the polypeptide.
US08420787B2 Organic compounds
The present invention relates to human thymic stromal lymphopoietin (hTSLP) antibodies and especially those which neutralize hTSLP activity. It further relates to methods for using anti-hTSLP antibody molecules in diagnosis or treatment of hTSLP related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease, and Hodgkin's lymphoma.
US08420786B2 Bispecific antibody targeting a complement factor or complement regulatory protein
A multispecific antagonist is disclosed that reacts specifically with at least two different targets. The targets are (A) proinflammatory effectors of the innate immune system, (B) coagulation factors, (C) complement factors and complement regulatory proteins, and (D) targets specifically associated with an inflammatory or immune-dysregulatory disorder or with a pathologic angiogenesis or cancer, wherein this latter target is not (A), (B) or (C). At least one of the targets is (C), and when the multispecific antagonist comprises a single multispecific antibody, then CD74 is excluded as a target of said antagonist. When the multispecific antagonist comprises a combination of separate antibodies, combinations are excluded where one of said antibodies targets a B-cell antigen and the other antibody targets a T-cell, plasma cell, macrophage or inflammatory cytokine and combinations are also excluded where one of said antibodies targets CD20 and the other antibody targets C3b or CD40.
US08420785B2 Soluble human ST-2 antibodies and assays
Provided herein are antibodies and antigen-binding antibody fragments that bind to human soluble Growth Stimulation-Expressed Gene 2 (ST2) protein, kits containing these antibodies and antibody fragments, and methods of using these antibodies and antibody fragments.
US08420783B2 Method and compositions for immunotherapy of inflammatory and immune-dysregulatory diseases
Methods and compositions for immunotherapy of inflammatory and immune-dysregulatory diseases, using multispecific antagonists that target at least two different markers are disclosed. The different targets include proinflammatory effectors of the innate immune system and targets specifically associated with an inflammatory or immune-dysregulatory disorder, wherein the targets included in the latter group are not a proinflammatory effector of the immune system. Thus, the multispecific antagonist contains at least one binding specificity related to the diseased cell or condition being treated and at least one specificity to a component of the immune system. The multispecific antagonists are used in the treatment of various diseases that are generated or exacerbated by, or otherwise involve, proinflammatory effectors of the innate immune system.
US08420781B2 Fluorescent protein
An object of the present invention is to provide a red or orange fluorescent protein, which is characterized in that the difference (stokes shift) between an excitation peak value (wavelength of maximum absorption) and a fluorescence peak value (wavelength of maximum fluorescence) is greatened, so that the maximum fluorescence can be obtained by the maximum excitation. The present invention provides a novel fluorescent protein monomerized by introducing a mutation into a florescent protein derived from Fungia sp., and a novel chromoprotein and fluorescent protein derived from Montipora. sp.
US08420778B2 Tripeptides and derivatives thereof for cosmetic application in order to improve skin structure
The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R1 represents H, —C(O)—R6, —SO2—R6 or —C(O)—XR6; R2 and R4, independent of one another, represent (CH2)n—NH2 or (CH2)3—NHC(NH)NH2; n equals 1 4; R3 represents linear or branched C1-C4 alkyl that is optionally substituted by hydroxy; R5 and R6, independent of one another, represent hydrogen, optionally substituted (C1-C24)alkyl, optionally substituted C2-C24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4 alkyl or 9-fluorenyl-methyl; X represents oxygen (—O—) or NH—; or XR5 with X═O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R1 and R5 do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).
US08420775B2 Polypeptides and methods for modulating D1-D2 dopamine receptor interaction and function
The present invention provides for prevention and/or treatment of neurological or neuropsychiatric disorders involving abnormal D1-D2 dopamine receptor coupling and/or activation. Methods and agents are provided for modulating dopamine receptor function arising from D1-D2 coupling and/or activation. Agents of the present invention include fragments of D2 receptor or D1 receptor that can disrupt D1-D2 coupling.
US08420774B2 Decorating hydroxyapatite biomaterials with modular biologically active molecules
A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a hydroxyapatite-binding portion and a biomolecule-derived portion. The modular peptides have improved non-covalent binding to the surface of the HA-based materials, and are capable of initiating osteogenesis, angiogenesis, and/or osteogenic differentiation.
US08420773B2 Process for producing water-absorbing polymer particles
A process for producing water-absorbing polymer particles, comprising polymerization of a monomer solution or suspension, drying the resulting polymer gel, and grinding and classifying the dried polymer gel, wherein the grinding is performed by means of a multistage roll mill, the first milling gap has a width of 500 to 5000 μm, the product mass flow passing through the first milling gap is conducted through a magnetic separator to the second milling gap, and the second milling gap has a smaller gap width than the first milling gap.
US08420771B2 PH-sensitive polyethylene oxide co-polymer and synthetic method thereof
Provided are a new pH-sensitive co-polymer prepared from polyethylene oxide and a method of preparing the same. The polyethylene oxide co-polymer includes repeating units expressed by the Chemical Formulas 1 and 2, and further includes at least one of repeating units expressed by the Chemical Formulas 3 through 6.
US08420763B2 Fluorooxyalkylene group-containing polymer composition, a surface treatment agent comprising the same and an article treated with the agent
An object of the present invention is to provide a fluorooxyalkylene group-containing polymer composition, which yields a coating having excellent adhesior to a substrate, good water- and oil-repellency, a low dynamic friction coefficient, good releasing property, good abrasion resistance and good stain resistance, and to provide a surface treatment agent comprising the same. The present inventors have found that a composition comprising a fluorooxyalkylene group-containing polymer having a fluorinated group and a hydrolyzable group at each terminal and a fluorooxyalkylene group-containing polymer having hydrolyzable groups at both terminals can form a coating which has excellent water- and oil-repellency, a low dynamic friction coefficient, good releasing property, good abrasion resistance, and good stain resistance.
US08420759B2 Polymers of isoprene from renewable resources
It has been found that certain cells in culture can convert more than about 0.002 percent of the carbon available in the cell culture medium into isoprene. These cells have a heterologous nucleic acid that (i) encodes an isoprene synthase polypeptide and (ii) is operably linked to a promoter. The isoprene produced in such a cultured medium can then be recovered and polymerized into synthetic rubbers and other useful polymeric materials. The synthetic isoprene containing polymers of this invention offer the benefit of being verifiable as to being derived from non-petrochemical based resources. They can also be analytically distinguished from rubbers that come from natural sources. The present invention more specifically discloses a polyisoprene polymer which is comprised of repeat units that are derived from isoprene monomer, wherein the polyisoprene polymer has δ13C value of greater than −22‰.
US08420756B2 Polymerisation of ethylene and alpha-olefins with catalyst systems based on binam derived ligands
The present invention relates to the field of single site catalyst systems based on aromatic BINAM diamine ligands and suitable for oligomerising or polymerising ethylene and alpha-olefins.
US08420751B2 Method for producing a polymer
Provided is a method for performing a polymerization process in a stirred reactor, wherein a critical time window is determined by means of a monitor of at least one polymerization process parameter and an associated process window, and when a critical time window is present, an adaptation of process conditions is made in order to configure the polymerization process to conform to the process window.
US08420748B2 Process for preparing branched Si-H functional polysiloxanes and use thereof for preparing liquid SiC- or SiOC-linked, branched modified organomodified polysiloxanes
The invention provides a process for preparing liquid, branched SiH-functional siloxanes by reacting a mixture of one or more low molecular weight SiH-functional siloxanes, one or more low molecular weight SiH-free siloxanes, one or more tetraalkoxysilanes, and optionally one or more trialkoxysilanes with addition of water and in the presence of a Brønsted-acidic ion exchanger, which is characterized in that the reaction is performed in one process step.
US08420747B2 Aliphatic polycarbonates for use in thermosetting powder coatings
A thermosetting polymer material capable of being used in powder coatings. The thermosetting polymer material includes at least one hydroxyl functional aliphatic polycarbonates that is formulated and crosslinked with isocyanates to yield a thermoset organic coating material. These materials provide improved weatherability as compared to prior art powder coating materials while also being less expensive than prior art materials utilizing fluorinated polymers.
US08420743B2 Propylene-based copolymer and film made of the same
A propylene-based copolymer is composed of 60 to 90% by weight of Component (A) that is a polymer component whose major structural unit is a structural unit derived from propylene and 10 to 40% by weight of Component (B) that is a propylene-ethylene copolymer component whose content of a structural unit derived from ethylene is 50 to 80% by weight, wherein the sum total of Component (A) and Component (B) is 100% by weight, wherein the ratio of the intrinsic viscosity of Component (B) ([η]B) to the intrinsic viscosity of Component (A) ([η]A)([η]B/[η]A) satisfies a formula: 1.3<[η]B/[η]A≦2.0, and the melt flow rate, measured at a temperature of 230° C. and a load of 21.18 N, of the copolymer is not less than 5 g/10 minutes and not more than 30 g/10 minutes.
US08420742B2 Interpolymers suitable for use in hot melt adhesives and processes to prepare the same
The present invention relates to an ethylene/α-olefin interpolymer product comprising at least one α-olefin interpolymerized with ethylene and, characterized in at least one aspect, as having improved properties when utilized in a hot melt adhesive formulation. The invention also relates to a process for manufacturing the interpolymer product wherein the process comprises employing two or more single site catalyst systems in at least one reaction environment (or reactor) and wherein the at least two catalyst systems have (a) different comonomer incorporation capabilities or reactivities and/or (b) different termination kinetics, both when measured under the same polymerization conditions. The interpolymer products are useful, for example, in applications such as hot melt adhesives, and also for impact, bitumen and asphalt modification, adhesives, dispersions or latexes and fabricated articles such as, but not limited to, foams, films, sheet, moldings, thermoforms, profiles and fibers.
US08420741B2 Ethylene based polymer composition and film
An ethylene based polymer composition comprising the following component (A) and the following component (B) wherein the content of the component (B) is 0.1 to 20 parts by weight per 100 parts by weight of the component (A):Component (A): an ethylene-α-olefin copolymer satisfying all of the following requirements (a1) to (a3): (a1) the density is 890 to 925 kg/m3, (a2) the melt flow rate (MFR) is 0.1 to 10 g/10 minutes, (a3) the flow activation energy (Ea) is less than 50 kJ/mol, Component (B): an ethylene-α-olefin copolymer satisfying all of the following requirements (b1) to (b3): (b1) the density is 890 to 925 kg/m3, (b2) the intrinsic viscosity [η] measured in a tetralin solution is 4 to 15 dL/g, (b3) the flow activation energy (Ea) is less than 50 kJ/mol.
US08420740B2 Method to repair a damaged intervertebral disc through the use of a bioadhesive, thermogelling hydrogel
The present invention is directed to a bioadhesive thermogelling hydrogel composition for repairing and/or augmenting an intervertebral disc. The bioadhesive thermogelling hydrogel composition can be cross linked with the surrounding tissue so as to potentially serve as a nucleus pulposus replacement or augmentation along with serving to repair annular tears or fissure. The bioadhesive thermogelling hydrogel composition may include three main components: a thermal responsive polymer, an amine-containing polymer and a crosslinking component. All three components can be modified and combined in numerous ways to serve the need of the system as long as the amine-containing component is kept separate from the crosslinking component until the components are injected. The incorporation of a two-part crosslinking thermal responsive hydrogel permits smaller amounts of the crosslinking component to be used and enables the crosslinking dialdehyde to be delivered locally into the tissue that will react with the hydrogel. This helps prevent damage to tissues away from the hydrogel.
US08420739B2 Fluorine-containing elastomer composition
There is provided a fluorine-containing elastomer composition assuring easy kneading and providing a crosslinked article having improved strength. The fluorine-containing elastomer composition comprises (A) an elastomer of a vinylidene fluoride/hexafluoropropylene copolymer having a branching coefficient of 30 to 300 ppm, a Mooney viscosity (ML1+10: 121° C.) of 7 to 80 and a molecular weight distribution (Mw/Mn) of 1.5 to 4, and (B) an elastomer of a vinylidene fluoride/hexafluoropropylene copolymer having a storage modulus G′ at 180° C. at 500 cpm of 500 to 900, and a mass ratio of (A)/(B) is 70/30 to 90/10.
US08420738B2 Thermoplastic elastomer composition and production process
A thermoplastic elastomer composition which has excellent cleanability and is suitable for use as a medical rubber supply. It is characterized by comprising a rubber ingredient dynamically crosslinked with a crosslinking agent and a matrix which comprises a thermoplastic resin and in which the crosslinked rubber ingredient has been dispersed, the crosslinking agent comprising a triazine derivative.
US08420730B2 Capsulated colorant, method of preparing the same, ink composition including the capsulated colorant
The present disclosure provides a capsulated colorant including a colorant and a polymer resin coating the colorant, wherein the polymer resin is obtained by polymerization of a polymerizable composition including a basic monomer, a macromonomer and a polymerizable unsaturated monomer; a method of preparing the capsulated colorant; and an ink composition including the capsulated colorant.
US08420728B2 Fiber-reinforced resin composition and molded body thereof
Long-fiber-reinforced thermoplastic resin particles and a blend thereof are provided, wherein the opening property of the reinforcing fibers during molding is good, and a molded body exhibiting an excellent appearance and having high mechanical strength is obtained. The particles (A) contain a thermoplastic resin (A1), produced by using a metallocene catalyst, a modified polyolefin resin (A2) modified with an unsaturated carboxylic acid or a derivative thereof, and reinforcing fibers (A3) and satisfying additional requirements described herein.
US08420727B2 Polycarbonate resin composition and preparation method thereof
A polycarbonate resin composition with excellent rigidity (flexural strength) and impact resistance, and a method of preparing the same are disclosed. The polycarbonate resin composition includes 1 to 70 parts by weight of a filament filler of 5˜30 mm based on 100 parts by weight of the total amount of a first polycarbonate resin (A) having a weight-average molecular weight of 25,000 g/mol or less, the filament filler (B), and one of a second polycarbonate resin (C) having a weight-average molecular weight of more than 25,000 g/mol and a rubber-modified styrene graft copolymer resin and a styrene copolymer resin (C′). The polycarbonate resin composition provides high rigidity and impact strength, and thus is useful to manufacture a variety of molded articles such as mobile products, electronic components, etc.
US08420725B2 Urethane resin composition, coating material, adhesive, cured product obtained using the same, and method for producing cured product
An object of the present invention is to provide a urethane resin composition that has excellent coating workability and storage stability not causing gelation with time and that can form a cured product such as a coating that has excellent heat resistance. The present invention relates to a urethane resin composition includes an alcohol-soluble urethane resin (A) having a hydrolyzable silyl group, inorganic particles (B), and an alcohol (C), in which the inorganic particles (B) have a functional group [Y] that can react with a functional group [X] generated from the hydrolyzable silyl group of the urethane resin (A), a coating material and an adhesive that contain the urethane resin composition, and a formed body obtained by using the urethane resin composition.
US08420723B2 Mix comprising trialkoxymercaptoalkyl-silanes
A method of producing a tire mix, including a first mixing step, in which a mix contains at least one cross-linkable unsaturated-chain polymer base, 10 to 100 phr of silica, and 1 to 20 phr of a silane bonding agent in the trialkoxymercaptoalkyl-silane class; and a final mixing step, in which a curing system is added to the mix. The silane bonding agent is used in adsorbed form on 0.5 to 2 phr of zinc oxide, and on 5 to 15 phr of carbon black. At the first mixing step, the mix contains 1 to 5 phr of one or more fatty acid derivatives, and, at the final mixing step, 1 to 2 phr of zinc oxide is added to the mix. The fatty acid derivatives are derived from condensation of a fatty acid, having a carbon number of 16 to 20, with an alcohol having a carbon number of 2 to 6, or with a primary or secondary amine having a carbon number of 2 to 6.
US08420722B2 Composition and methods of forming solder bump and flip chip using the same
Provided are a composition for an anisotropic conductive adhesive, a method of forming a solder bump and a method of forming a flip chip using the same. The composition for an anisotropic conductive adhesive includes a low melting point solder particle and a thermo-curable polymer resin. The anisotropic conductive adhesive includes forming a mixture by mixing a polymer resin and a curing agent, and mixing a deforming agent, a catalyst or a reductant with the mixture.
US08420721B2 Polyolefin resin composition
A polyolefin resin composition having a high crystallization temperature and excellent transparency is provided. The polyolefin resin composition comprises 0.01 to 10 parts by mass of a methylenebisanilide compound with respect to 100 parts by mass of a polyolefin resin, wherein the methylenebisanilide compound is represented by General Formula 1, wherein each of X1, X2, X3, X4, X5, X6, X7 and X8 independently represents a hydrogen atom or C1-C10 alkyl which is optionally substituted or branched; and each of R1 and R2 independently represents a hydrogen atom, C1-C21 alkyl which is optionally substituted or branched, C3-C12 cycloalkyl which is optionally substituted, or C6-C20 aryl which is optionally substituted.
US08420718B2 Composition, polymerizable composition, resin, optical component, and method for producing the composition
The composition of the present invention contains a product having a thiol group obtained by reacting an Sb or Bi oxide or an Sb or Bi halide with at least one kind of polythiol compounds selected from compounds having at least two thiol groups in a molecule.
US08420717B2 Polyol functionalized water soluble carbon nanostructures
A method of making a water soluble carbon nanostructure includes treating a fluorinated carbon nanostructure material with a polyol in the presence of a base. A water soluble carbon nanostructure comprises a fluorinated carbon nanostructure covalently bound to a polyol. Exemplary uses of water soluble carbon nanostructures include use in polymer composites, biosensors and drug delivery vehicles.
US08420713B2 Capsulated colorant, method of preparing the same, and ink composition including the capsulated colorant
Provided are a capsulated colorant, a method of preparing same and ink compositions including the capsulated colorant. The capsulated colorant includes a colorant and a polymer resin coated on the colorant. The polymer resin is a result of polymerization of a polymerizable composition comprising a basic monomer and a polymerizable unsaturated monomer. The ink composition comprises the colorant coated with the polymeric resin and a solvent, which may be water and at least one organic solvent.
US08420711B2 Mono ethylenically unsaturated polymerizable group containing polycarbosiloxane monomers
The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain monoethylenically unsaturated polymerizable group containing polycarbosiloxane monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices.
US08420708B2 Methods for making dental restorations using two-phase light-curing materials
Methods for making dental crowns, bridges, inlays, onlays, veneers, fillings, and other restorations are provided. The methods involve using a two-phase light curing (TPLC) material. Preferably, the TPLC material used to form the dental restoration comprises a blend of polymerizable compounds; photopolymerization systems (a) and (b), and particulate filler materials (a) and (b). In a first light-curing step, curing light having a wavelength of greater than 420 nm is used to activate system (a). In a second light-curing step, curing light having a wavelength of less than 420 nm is used to activate system (b). The two step light-curing method is efficient and allows the dentist to make restorations having high mechanical strength and pleasing aesthetics.
US08420707B2 Biomass composite composition and foaming method thereof
Disclosed herein are a biomass composite composition and a foaming method thereof. The biomass composite composition includes (a) polyester alloy containing biodegradable polyester and petrochemical plastic, (b) reinforcing agent, (c) foaming agent, (d) compatibilizer, (e) lubricant, and (f) impact modifier. The biomass composite composition of the present invention is biodegradable and of heat resistance and melt strength suitable for manufacture of foam products.
US08420705B2 Particulate materials for acoustic texture material
A composition for forming a textured coating on drywall material, where the textured coating substantially matches a pre-existing acoustic texture material on the drywall material, comprises acoustic texture material and propellant material. The acoustic texture material comprises a base portion the base portion is capable of existing in a flowable state and a hardened state, and a particulate portion the particulate portion comprises discrete, visible particles of solidified urethane foam having irregular shapes. The propellant material comprises a hydrocarbon propellant. The particles of urethane foam are distributed throughout the acoustic texture material when the base portion is in the flowable state. The irregular shapes of the particulate portion are substantially the same when the base portion is in the flowable state and in the hardened state. The base portion is capable of securing the discrete, visible, particles of solidified urethane foam to the drywall material when the base portion is in the hardened state.
US08420704B2 Nano-structured polymer composites and process for preparing same
A process for preparing a polymer composite that includes reacting (a) a multi-functional monomer and (b) a block copolymer comprising (i) a first block and (ii) a second block that includes a functional group capable of reacting with the multi-functional monomer, to form a crosslinked, nano-structured, bi-continuous composite. The composite includes a continuous matrix phase and a second continuous phase comprising the first block of the block copolymer.
US08420701B2 Polymer electrolyte membrane, membrane-electrode assembly for polymer electrolyte fuel cells and process for producing polymer electrolyte membrane
A polymer electrolyte membrane comprises at least one layer of a perforated sheet having many through-holes formed substantially parallel to the thickness direction with an average cross-sectional area per hole ranging from 1×10−3 to 20 mm2, wherein the numerical aperture based on the through-holes ranges from 30 to 80%, and the through-holes are filled with an ion exchange resin.
US08420698B2 Histone deacetylase inhibitors
Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy.
US08420697B2 Treatment of acute exacerbation of asthma and reduction of likelihood of hospitalization of patients suffering therefrom
The invention provides a method of improving one or more clinical outcomes of an individual experiencing an acute respiratory attack. The acute respiratory attack may include acute reversible bronchospasm, severe acute bronchospasm, or acute exacerbation of asthma. The method includes administering to an individual suffering from an acute respiratory attack an effective amount of bedoradrine or a pharmaceutically acceptable salt thereof in combination with a standard of care (SOC) treatment regimen.
US08420694B2 Pyrrolidin-2-one derivatives as androgen receptor modulator
A compound represented by the formula (I′): or a salt thereof, has a superior androgen modulating action, wherein R1, R2, R4 to R8, R10 and R11 are defined in the claim.
US08420690B2 Inhibitors of Akt activity
Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
US08420689B2 Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
The present invention relates to novel cannabinoid receptor modulators, in particular cannabinoid 1 (CB1) or cannabinoid 2 (CB2) receptor modulators, and uses thereof for treating diseases, conditions and/or disorders modulated by a cannabinoid receptor.
US08420683B2 5 substituted hydantoins
The present invention relates to 5-substituted hydantoins, a process for the preparation of 5-substituted hydantoins and the use of 5-substituted hydantoins in the preparation of enantiomerically enriched α-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel 5-substituted hydantoins.
US08420679B2 Aminothiazole derivatives and their use as CRF receptor ligands
Substituted 4-phenyl-2-aminothiazole derivatives, processes for preparing the same, and the use thereof as corticotrophin releasing factor (CRF) antagonists.
US08420678B2 Small molecule inhibitors of the pleckstrin homology domain and methods for using same
Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
US08420677B2 Use of 3,3′-diindolylmethane
Use of DIM and/or its derivatives for prevention, treatment and/or delay of age-related hearing loss in mammals.
US08420672B2 Solid forms of 3-(4-amino-1-oxo-1,3-dihydro-isoindo1-2-yl)-piperidine-2,6-dione and methods of making the same
The present invention provides for new crystalline and amorphous forms of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione, and methods of making the same.
US08420671B2 Stabilised thiophene derivatives
The present invention relates to a stabilized monomer composition comprising at least 50 wt.-%, based on the total weight of the stabilized monomer composition, of a thiophene derivative monomer having the general formula (I) in which R1 and R2 stand, independently of one another, for hydrogen, for an optionally substituted C1-C20-alkyl group or C1-C20-oxyalkyl group, optionally interrupted by 1 to 5 oxygen atoms and/or sulfur atoms, or jointly for an optionally substituted C1-C20-dioxyalkylene group or C6-C20-dioxyarylene group, and 0.001 to 10 wt.-%, based on the total weight of the stabilized monomer composition, of a stabilizer. The present invention also relates to a method for the manufacture of a capacitor, a capacitor obtained by this method, the use of a stabilized monomer composition and to the use of a stabilizer.
US08420669B2 Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the BETA2 adrenergic receptor
The present disclosure relates to 4-(2-amino-1-hydroxyethyl)phenol derivatives of formula (I) as well as pharmaceutical compositions comprising them, and their use in therapy as agonists of the BETA2 adrenergic receptor.
US08420666B2 Pyrazolo (3, 4-B) pyridine derivatives as phosphodiesterase inhibitors
The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed herein having the structure of Formula 1: can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4/PDE type 7 inhibitors are provided.
US08420664B2 A3 adenosine receptor allosteric modulators
The present invention relates to allosteric modulation of A3 adenosine receptor (A3AR) and provides for the use of an A3 adenosine receptor modulator (A3RM), for the preparation of pharmaceutical compositions for modulating the A3AR in a subject, as well as pharmaceutical compositions comprising the same and therapeutic methods comprising administering to a subject an amount of an A3RM, the amount being effective to modulate A3AR activity. The A3RM according to the invention are 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives. The invention also provides some of such novel 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives.
US08420663B2 Peripheral opioid receptor antagonists and uses thereof
The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
US08420660B2 Antitubercular alkaloid
A derivative of β-carboline alkaloid harmine, 10,12-diheptanoyl-11-hydroxy-3-methyl-β-carboline, prepared by a Friedel-Crafts acylation of harmine is reported as a novel potent antitubercular drug.
US08420655B2 Benzimidazole inhibitors of leukotriene production
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salt thereof, wherein R1-R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
US08420654B2 1,5-Diphenyl-pyrrolidin-2-one compounds as CB-1 ligands
CB-1 receptor inverse agonist compounds of Formula and pharmaceutical compositions for the treatment of obesity or cognitive impairment associated with schizophrenia.
US08420653B2 Pyrimidine compounds and their uses
Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases.
US08420651B2 Substituted 1-alkylcinnolin-4(1H)-one derivatives, preparation thereof and therapeutic application of same
The subject of the present invention is compounds corresponding to the formula (I) in which: X represents a divalent (C2-C5)alkylene radical which is unsubstituted or substituted one or more times by an Alk group; R1 represents a phenyl, a naphthyl, a pyridyl, a 1-benzothienyl or a 1,3-benzodioxolyl; R2 represents a hydrogen atom, a halogen atom, an Alk group, an OAlk group or else a group chosen from —S-Alk, —SO-Alk, —SO2-Alk, —CO—N(R4)-Alk, —N(R4)SO2-Alk, —N(R4)CO-Alk, —N(R4)SO2—N(Alk)2; R3 represents a hydrogen atom, a halogen atom, an Alk group or an OAlk group; R4 represents a hydrogen atom or a (C1-C4)alkyl; Alk represents an unsubstituted or substituted (C1-C4)alkyl. Preparation process and therapeutic application.
US08420650B2 Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP)
A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.
US08420648B2 Polymorphs of brimonidine pamoate
A brimonidine pamoate polymorph exhibits characteristics disclosed herein, wherein the brimonidine pamoate has the following formula The polymorph is included in a composition, device, or implant for use in the treatment or control of elevated intraocular pressure or in the neuroprotection of components of a neurological tissue to prevent progressive degeneration of such components. In particular, such a composition, device, or implant can be used to provide neuroprotection to cells and components of the optic nerve system.
US08420643B2 Compounds and method for treatment of cancer
The present invention is directed to methods of use of a compound of Formula I: and/or a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical isomer, or combination thereof, a composition comprising the thiosemicarbazone, a method of administration thereof, and use thereof to treat a cancer.
US08420639B2 Arylsulfonamide CCR3 antagonists
Provided herein are arylsulfonamides that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3-mediated disorder, disease, or condition.
US08420633B2 Aryl-cyclohexyl-tetraazabenzo[e]azulenes
The present invention is concerned with aryl-cyclohexyl-tetraazabenzo[e]azulenes of formula I wherein R1, R2 and R3 are as described herein. The invention further provides methods for the manufacture of such compounds and pharmaceutical compositions containing them. The compounds according to the invention act as V1a receptor modulators, and in particular as V1a receptor antagonists. The compounds are useful as therapeutics acting peripherally and centrally in the conditions of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior.
US08420630B2 Pyrimidine derivatives
The present invention relates to trisubstituted pyrimidines of formula (I) wherein 0Ra to Re are defined as in claim 1, which are suitable for the treatment of illnesses characterized by excessive or abnormal cell proliferation, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.
US08420629B2 Azetidine and cyclobutane derivatives as JAK inhibitors
The present invention relates to azetidine and cyclobutane derivatives, as well as their compositions, methods of use, and processes for preparation, which are JAK inhibitors useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
US08420626B2 Arene connected polyamine macrocyclic derivatives, preparation methods and pharmaceutical uses thereof
The present invention relates to arene connected polyamine macrocyclic derivatives represented by general formula I, pharmaceutically acceptable salts or hydrates thereof which have anti-HIV activities, in which the definitions of substituents are as defined in the description; to preparation methods of the compounds of formula I; to pharmaceutical compositions containing the compounds of formula I or their pharmaceutically acceptable salts or hydrates; to the use of the compounds of formula I or their pharmaceutically acceptable salts or hydrates for the preparation of a medicament for the treatment and prevention of HIV-associated diseases.
US08420625B2 Lipolytic methods for regional adiposity
Compositions, formulations, methods, and systems for treating regional fat deposits comprise contacting a targeted fat deposit with a composition comprising long acting beta-2 adrenergic receptor agonist and a compound that reduces desensitization of the target tissue to the long acting beta-2 adrenergic receptor agonist, for example, glucocorticosteroids and/or ketotifen. Embodiments of the composition are administered, for example, by injection, and/or transdermally.
US08420624B2 Methods for treating or preventing symptoms of hormonal variations
The present invention relates to methods for treating or preventing symptoms of hormonal variation. The method comprises the steps of administering an effective amount of a receptor antagonist to a subject having one or more symptoms of hormonal variations, wherein the receptor antagonist binds to at least one receptor selected from the group consisting of a serotonin type 2A (5-HT2A) and a dopamine type 2 (D2) receptors.
US08420621B2 Methods of using gamma cyclodextrin to control blood glucose and insulin secretion
Disclosed are methods of producing a blunted postprandial glycemic response in an individual, and/or reducing postprandial insulin secretion, said methods comprising administering to the individual a nutritional or other product comprising gamma-cyclodextrin. Also disclosed are similar other methods directed toward the use of such products to provide weight and appetite control, to normalize blood glucose levels in individuals with impaired glucose tolerance, to minimize nighttime hypoglycemia in diabetic and non-diabetic patients, to prevent reactive hypoglycemia in susceptible non-diabetics, to normalize blood glucose levels in individuals with gestational diabetes or impaired glucose tolerance during gestation, and/or to provide a prolonged glycemic response during exercise. The methods are based upon the discovery that gamma-cyclodextrins are rapidly metabolized and absorbed in the small intestine, but subsequently result in a surprisingly blunted postprandial glycemic response and reduced insulin secretion.
US08420620B2 Induced internalization of surface receptors
Disclosed is a hetero-bifunctional ligand for use in inducing internalization of a target receptor. The hetero-bifunctional ligand includes a target receptor-binding agent that specifically binds the target receptor linked to an internalizing receptor-binding agent that specifically binds to an internalizing receptor, where the two binding agents are non-identical. Also disclosed is a method of inducing the internalization of a target receptor on a cell. The method includes contacting a cell with a hetero-bifunctional ligand, where binding of the hetero-bifunctional ligand induces internalization of a target receptor of the cell. Also disclosed a method of treating a disease or condition associated with a target receptor using the disclosed hetero-bifunctional ligand and pharmaceutical compositions including a hetero-bifunctional ligand.
US08420617B2 Multiantivirus compound, composition and method for treatment of virus diseases
A method for obtaining a new antiviral compound with multiple action against many viruses, comprising modified highly purified yeast RNA, a pharmaceutical composition comprising such RNA, and a method for the treatment and prevention of viral disease comprising administering to a patient a composition comprising an amount effective to ameliorate the symptoms of viral disease of ribonucleic acid. The exogenous modified yeast RNA has a pronounced multiple anti-virus action in a wide range of concentrations. The modified yeast RNA is capable of inhibiting the reproduction of viruses from Orthomyxoviridae, Paramyxovirus, Hepatitis, Herpesviridae families, enterovirus and adenovirus. Also, the modified yeast RNA is capable of inhibiting the reproduction of influenza viruses, hepatitis C virus, genital herpes, human immunodeficiency virus and Coxsackie B virus.
US08420611B2 Combined gene therapy for the treatment of macroscopic gliomas
Described herein are compositions and methods for the treatment of cancer, and particularly brain cancer (e.g., glioma) in a mammal. In various embodiments of the invention, a combined therapeutic approach including TK with systemic ganciclovir administration and Flt3L are used in connection with gene therapeutic techniques or direct peptide injection for the aforementioned indications. Kits useful in practicing the inventive method are also disclosed, as are animal models useful for studying brain cancer.
US08420606B2 Method of utilizing physiological activity of rare saccharide and composition containing rare saccharide
A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.
US08420602B2 Endocannabinoid conjugate and a pharmaceutical composition for treatment of neuronal disorders
A compound provided by the present invention includes an endocannabinoid, endocannabinoid derivative, or endocannabinoid analog moiety covalently bonded to a biologically active peptide. One example of an inventive compound described is a conjugate of an endocannabinoid, endocannabinoid derivative, or endocannabinoid analog moiety covalently coupled to an opioid peptide, such as an endorphin, enkephalin, dynorphin or endomorphin. Also detailed are processes for making the described conjugates and pharmaceutical compositions including such compounds.
US08420600B2 Injectable capsaicin
The present invention is directed to compositions and methods for relieving pain at a site in a human or animal by administering at a discrete site in a human or animal a dose of capsaicin in an amount effective to denervate the discrete site without eliciting an effect outside the discrete location.
US08420599B2 Bone-reinforcing food material
Disclosed is a bone-reinforcing agent which comprises a milk protein fraction having the following properties (1) to (4): (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein component having a molecular weight of 6,000 to 150,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 12 to 14 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.5 to 0.7; and (4) the milk protein fraction has an activity of accelerating the calcification in an osteoblast.
US08420598B2 Mono modified exendin with polyethylene glycol or its derivatives and uses thereof
Disclosed herein are exendin singly modified with polyethylene glycole or a derivative thereof, a method for the preparation of the same, and uses thereof. Exendin modified at lysine (27) with polyethylene glycol shows biological activity similar to that of natural exendin, but is improved in half life. In addition, the modification position and the number of PEG or its derivative are restricted so as to minimize the side effects caused by a variety of combinations of such factors. The exendin is useful in the prevention and treatment of diseases caused by the over-secretion of insulin, or diseases caused due to a decrease in plasma glucose level, the inhibition of gastric or intestinal motility, the promotion of satiety, or the inhibition of food intake, especially diabetes, obesity and irritable colon syndrome.
US08420595B2 Methods for treating acute acoustic trauma
The current invention provides methods and compositions for treating sensorineural hearing loss including but not limited to acute acoustic trauma (AAT). The composition includes compounds which function as free radical traps such as phenyl butyl nitrone (PBN), free radical scavengers, such as edaravone, resveratrol, ebselen and iron chelator and compounds from the family of antioxidant compounds including, but not limited to, N-acetylcysteine (NAC), Acetyl-L-Carnitine (ALCAR), glutathione monoethylester, ebselen, D-methionine and carbamathione. The compositions of the current invention may be delivered by injections or orally.
US08420594B2 Inhibitors of MRP4 and agents stimulating MRP4 activity for the treatment of cardiac disorders
The invention relates to inhibitors of Multi drug Resistant Protein 4 (MRP4) for the treatment and/or the prevention of cardiac disorders, such as acute or chronic heart failure and cardiogenic shock. The invention also relates to agents stimulating MRP4 activity for the treatment and/or the prevention of cardiac hypertrophy.
US08420593B1 Compositions and methods for regulating membrane potential
Compositions are described according to embodiments of the present invention which include a neuronal potassium channel antagonist and a neuronal sodium channel antagonist, the neuronal potassium channel antagonist and the neuronal sodium channel antagonist each conjugated to a transporter moiety to form one or more conjugates. The transporter moiety is capable of crossing the blood/brain or blood/nerve barrier such that the conjugate is delivered to the brain and/or nerve. Inventive methods of treating a demyelinating condition in a subject are described herein which include administering an effective amount of a conjugate composition of the present invention to a subject having a demyelinating condition.
US08420590B2 Genes and proteins that home to developing microvessels
Described herein are polypeptides that home to developing microvasculature, (also referred to as developing microvessels), such as newly developing microvasculature in mammals, particularly in humans, and to DNA that encodes such polypeptides. These polypeptides are referred to herein as developing microvasculature homing polypeptides. In a specific embodiment, the homing peptides are collateral vessel endothelia (CVE) homing polypeptides, which have been shown to home to collateral vessel endothelia after ischemia.
US08420586B2 Thickened oven cleaner comprising a glutamic acid salt or disodium ethanol diglycine chelant
Cleaner compositions, associated cleaners, and associated methods are disclosed. The cleaner compositions are capable for use in making thickened cleaners that are capable of removing from vertical and inverted surfaces fresh, greasy soils and baked-on soils encountered in the food service industry. The cleaner compositions include one or more alkalinity sources, one or more chelants, one or more surfactants, one or more thickening agents, one or more buffers, and as a remainder, water. Cleaner compositions of the invention are substantially free of phosphates and have a low caustic content making them user and environmentally friendly. Yet the cleaners of the invention are surprisingly effective at removing tenacious baked-on soils encountered in the food service industry. Compositions of the invention have a viscosity of about 700 cps and are applied using a foaming or misting dispenser. The one or more alkalinity sources may be present in an amount sufficient to provide a free alkalinity (expressible as Na2O) of less than about 1.0 wt % and a total alkalinity (expressible as Na2O) of less than about 2.0 wt %, based on the total weight of the cleaner concentrate. The one or more chelants may be present in an amount up to about 5.0 wt %.
US08420582B2 Friction and wear modifiers using solvent partitioning of hydrophilic surface-interactive chemicals contained in boundary layer-targeted emulsions
A wear and/or friction reducing additive for a lubricating fluid in which the additive is a combination of a moderately hydrophilic single-phase compound and an anti-wear and/or anti-friction aqueous salt solution. The aqueous salt solution produces a coating on boundary layer surfaces. The lubricating fluid can be an emulsion-free hydrophobic oil, hydraulic fluid, antifreeze, or water. Preferably, the moderately hydrophilic single-phase compound is sulfonated castor oil and the aqueous salt solution additionally contains boric acid and zinc oxide. The emulsions produced by the aqueous salt solutions, the moderately hydrophilic single-phase compounds, or the combination thereof provide targeted boundary layer organizers that significantly enhance the anti-wear and/or anti-friction properties of the base lubricant by decreasing wear and/or friction of sliding and/or rolling surfaces at boundary layers.
US08420576B2 Hydrophobically and cationically modified relative permeability modifiers and associated methods
Methods comprising introducing a hydrophobically and cationically modified relative permeability modifier into a portion of a subterranean formation. The hydrophobically and cationically modified relative permeability modifier comprises a hydrophilic polymer backbone with a hydrophobic modification and a cationic modification. The cationic modification may comprise at least one cationic compound comprising an alkyl chain length of from 1 to 3 carbons.
US08420570B2 Chiral 3-(benzylsulfinyl)-5,5-dimethyl-4,5-dihydroisoxazole derivatives and 5,5-dimethyl-3-[(1H-pyrazol-4-ylmethyl)sulfinyl]-4,5-dihydroisoxazole derivatives, method for the production thereof, and use of same as herbicides and plant growth regulations
The invention relates to 3-(benzylsulfinyl)-5,5-dimethyl-4,5-dihydroisoxazole derivatives and 5,5-dimethyl-3-[(1H-pyrazol-4-ylmethyl)sulfinyl]-4,5-dihydroisoxazole derivatives of the formula (I) and their salts processes for their preparation and their use as herbicides and plant growth regulators, in particular as herbicides for the selective control of harmful plants in crops of useful plants.
US08420568B2 Color-developing compositions and recording material containing same
Provided is a color-developing composition for recording materials having a superior heat resistance. The color-developing composition is a reaction composition containing a mixture of compounds represented by formula (III) obtained by reacting a dihydroxydiphenylsulfone derivative represented by formula (I) with a dihalide represented by formula (II) X—Y—X (II), wherein, in a composition where the content of a compound with n=1 in said reaction composition is from 5 to 80% by mass of the total solid content of the composition, at least 10% by mass of the compound with n=1 is a crystalline material.
US08420567B1 Process for superabsorbent polymer and crosslinker composition
The present invention further relates to a process to make a superabsorbent polymer comprising the steps of a) preparing a neutralized monomer solution comprising a polymerizable monomer selected from unsaturated acid groups-containing monomers, ethylenically unsaturated carboxylic acid anhydride, salts, or derivatives thereof and a caustic agent selection from an alkali agent, wherein the polymerizable monomer is neutralized to from about 50 mol % to about 85 mol %; b) forming a crosslinker monomer mixture by adding an internal crosslinker composition to the neutralized monomer solution wherein the internal crosslinking composition is the reaction product of a stoichiometric excess of amine with a glycidyl compound, wherein the internal crosslinker composition has a residual amount of glycidyl compounds of less than about 500 ppm based on the mass of the internal crosslinker composition; and c) polymerizing the crosslinker monomer mixture to make a superabsorbent polymer.
US08420566B2 High efficiency ammoxidation process and mixed metal oxide catalysts
A process and novel catalyst for the production of acrylonitrile, acetonitrile and hydrogen cyanide characterized by the relative yields of acrylonitrile, acetonitrile and hydrogen cyanide produced in the process and by the catalyst, which are defined by the following: α=[(% AN+(3×% HCN)+(1.5×% ACN))÷% PC]×100 wherein % AN is the Acrylonitrile Yield and % AN≧81, % HCN is the Hydrogen Cyanide Yield, % ACN is the Acetonitrile Yield, % PC is the Propylene Conversion, and α is greater than 100.
US08420564B2 Sulfur-tolerant catalyst prepared through high pressure decomposition
A method of producing a MoS2 catalyst. The method begins by the decomposition of ammonium tetrathiomolybdate in an organic solvent. This decomposition is done in the presence of a solution comprising: a solvent and a promoter, and done under gaseous pressure.
US08420560B2 Dielectric ceramic, method for producing dielectric ceramic, and method for producing powder for producing dielectric ceramic
A dielectric ceramic includes a main component and a minor component. The main component includes a BaTi4O9 crystal phase and a Ba2Ti9O20 crystal phase, is represented by BaO.xTiO2, has a molar ratio x of TiO2 to BaO of 4.6 to 8.0, and in X-ray diffraction, and has an X-ray diffraction peak intensity ratio I29/I14 of a maximum diffraction peak intensity (I14) of the BaTi4O9 crystal phase to a maximum diffraction peak intensity (I29) of the Ba2Ti9O20 crystal phase of 1 or more. The minor component includes a boron oxide and a copper oxide, in which the boron oxide content is in the range of 0.5 to 5.0 parts by mass with respect to 100 parts by mass of the main component, and the copper oxide content is in the range of 0.1 to 3.0 parts by mass with respect to 100 parts by mass of the main component.
US08420559B2 Multilayer ceramic capacitor
Disclosed is a multilayer ceramic capacitor which is formed by alternately laminating (i) dielectric layers composed of a dielectric ceramic and (ii) internal electrode layers. The dielectric ceramic is composed of crystal grains mainly composed of barium titanate, while containing predetermined amounts of magnesium, vanadium, manganese and terbium, and at least one rare earth element selected from yttrium, dysprosium, holmium and erbium. In an x-ray diffraction chart of the dielectric ceramic, the diffraction intensity of the (200) plane indicating cubic barium titanate is higher than the diffraction intensity of the (002) plane indicating tetragonal barium titanate. The dielectric ceramic has a Curie temperature of 110-120° C.
US08420555B2 Manufacturing method for semiconductor device and manufacturing apparatus for semiconductor device
A manufacturing method for a semiconductor device including: determining pattern dependency of a radiation factor of an element forming surface of one wafer having a predetermined pattern formed on the wafer; determining a heating surface of the wafer, based on the pattern dependency of the radiation factor; holding the one wafer having the determined heating surface and another wafer having a determined heating surface, spaced at a predetermined distance in such a manner that non-heating surfaces of the one wafer and the another wafer oppose to each other; and heating the each heating surface of the one wafer and the another wafer.
US08420550B2 Method for cleaning backside etch during manufacture of integrated circuits
A method for manufacturing semiconductor substrates. The method includes providing a semiconductor wafer, which has an upper surface, a backside surface, and an edge region around a periphery of the semiconductor wafer. In a preferred embodiment, the upper surface is often for the manufacture of the integrated circuit device elements themselves. The method includes subjecting the semiconductor wafer to one or more process steps to form one or more films of materials on the backside surface. The method mounts the semiconductor wafer to expose the backside surface. The method rotates the semiconductor wafer in a circular manner. In a specific embodiment, the method includes supplying an acid solution containing fluorine bearing species, a nitric acid species, a surfactant species, and an organic acid species, on at least the backside surface as the semiconductor wafer rotates. The method causes removal of one or more contaminants from the backside surface, while a portion of the center region of the backside surface remains exposed as the semiconductor wafer rotates in the circular manner.
US08420549B2 Etching and cleaning methods and etching and cleaning apparatuses used therefor
A method of manufacturing a semiconductor device includes preparing a semiconductor wafer having a device area, an end face, and a surface peripheral area located outside the device area and between the end face and the device area. Forming a Cu layer on the semiconductor wafer and rotating the wafer in a horizontal plane. Emitting a first liquid from an edge nozzle towards the surface peripheral area which selectively removes a first unnecessary material in the surface peripheral area. Emitting a protecting liquid toward the semiconductor wafer, thereby protecting the device area from the first liquid. An angle of a longitudinal axis of the edge nozzle with respect to a tangent of the semiconductor wafer at a point, where the longitudinal axis of the edge nozzle intersects the end face of the wafer, is set in the range of 0 to 90 degrees in plan view.
US08420548B2 Method for treating germanium surfaces and solutions to be employed therein
The present invention concerns an improved method for treating germanium surfaces in order to reveal crystal defects.
US08420547B2 Plasma processing method
A plasma processing method performed in a plasma processing apparatus including a processing chamber accommodating a substrate in which a plasma is generated; a mounting table mounting the substrate, which is provided in the processing chamber and to which a plasma attraction high frequency voltage is applied; and a facing electrode provided to face the mounting table in the processing chamber, to which a negative DC voltage is applied, the method including: applying a plasma attraction high frequency voltage to the mounting table for a predetermined period of time; and stopping the application of the plasma attraction high frequency voltage to the mounting table. In the plasma processing method, the application of the plasma attraction high frequency voltage and stopping thereof are alternately repeated.
US08420544B2 Method for fabricating interconnection structure with dry-cleaning process
A method for fabricating an interconnection structure includes the following steps. Firstly, a substrate having a first conductive layer thereon is provided. Next, an ultra low-k material layer is formed on the substrate. Next, a portion of the ultra low-k material layer is removed, so as to form an opening to expose the first conductive layer. Next, a dry-cleaning process is performed by using gas, so as to clean a surface of the first conductive layer exposed by the opening. The dry-cleaning process is performed at a temperature in a range from the room temperature to 100° C.
US08420542B2 Method of patterned image reversal
A method of forming a reverse image pattern on a semiconductor base layer is disclosed. The method comprises depositing a transfer layer of amorphous carbon on the semiconductor base layer, depositing a resist layer on the transfer layer, creating a first pattern in the resist layer, creating the first pattern in the transfer layer, removing the resist layer, depositing a reverse mask layer, planarizing the reverse mask layer, and removing the transfer layer, thus forming a second pattern that is a reverse image of the first pattern.
US08420532B2 Method of manufacturing semiconductor device
The present invention relates to a method of fabricating a semiconductor device. According to the method, a first insulating layer having a contact hole formed therein is formed over a semiconductor substrate. A second insulating layer is gap filled within the contact hole. A third insulating layer having a trench formed therein is formed over the semiconductor substrate including the contact hole. The second insulating layer gap filled within the contact hole is removed. A contact plug and a bit line are formed within the contact hole and the trench.
US08420529B2 Copper wiring surface protective liquid and method for manufacturing semiconductor circuit
A copper wiring material surface protective liquid for production of a semiconductor device is provided, containing an oxyalkylene adduct of an acetylenediol containing an acetylenediol having an oxyalkylene having 2 or 3 carbon atoms added thereto. A method for producing a semiconductor circuit device is provided, containing: forming an insulating film and/or a diffusion preventing film on a silicon substrate; then forming a copper film by a sputtering method; then forming a copper wiring containing 80% by mass or more of copper thereon by a plating method; and flattening the wiring by a chemical mechanical polishing (CMP) method, thereby providing a semiconductor substrate containing a copper wiring, the semiconductor substrate having an exposed surface of a copper wiring material being treated by making in contact with the copper wiring material surface protective liquid.
US08420519B1 Methods for fabricating integrated circuits with controlled P-channel threshold voltage
Methods are provided for fabricating integrated circuits having controlled threshold voltages. In accordance with one embodiment a method includes forming a gate dielectric overlying an N-doped silicon substrate and depositing a layer of titanium nitride and a layer of tantalum nitride overlying the gate dielectric. A sub-monolayer of tantalum oxide is deposited overlying the layer of tantalum nitride by a process of atomic layer deposition, and oxygen is diffused from the tantalum oxide through the tantalum nitride and titanium nitride.
US08420518B2 Structure and method of latchup robustness with placement of through wafer via within CMOS circuitry
A method of manufacturing a semiconductor structure includes: forming a trench in a back side of a substrate; depositing a dopant on surfaces of the trench; forming a shallow trench isolation (STI) structure in a top side of the substrate opposite the trench; forming a deep well in the substrate; out-diffusing the dopant into the deep well and the substrate; forming an N-well and a P-well in the substrate; and filling the trench with a conductive material.
US08420515B2 Method of producing a solar cell
A method for manufacturing a solar cell is disclosed. A conductive layer is introduced into a mold having an interior defining a shape of a solar cell. A planar capillary space is formed along the conductive layer. A measure of silicon is placed in fluid communication with the capillary space. The silicon is melted and allowed to flow into the capillary space. The melted silicon is then cooled within the capillary space such that the silicon forms a p-n junction along the conductive layer.
US08420513B2 Method of fabricating thin film transistor
A thin film transistor (TFT), including a crystalline semiconductor pattern on a substrate, a gate insulating layer on the crystalline semiconductor pattern, the gate insulating layer having two first source/drain contact holes and a semiconductor pattern access hole therein, a gate electrode on the gate insulating layer, the gate electrode being between the two first source/drain contact holes, an interlayer insulating layer covering the gate electrode, the interlayer insulating layer having two second source/drain contact holes therein, and source and drain electrodes on the interlayer insulating layer, each of the source and drain electrodes being insulated from the gate electrode, and having a portion connected to the crystalline semiconductor pattern through the first and second source/drain contact holes.
US08420508B2 Integrated circuit packaging system with bump contact on package leads and method of manufacture thereof
A method of manufacture of an integrated circuit packaging system includes: providing a base panel having a first side with a cavity and a second side opposite the first side; connecting an integrated circuit device and the first side; applying a resist mask having an opening on the second side, the opening offset from the cavity; forming a bump contact in the opening; applying an encapsulation in the cavity over the integrated circuit device and the first side; and forming a package lead by removing a portion of the base panel under the cavity, a flared tip of the package lead intersecting a base side of the encapsulation.
US08420507B2 Laser processing method
A modified region 7 to become a starting point region for cutting is formed in a GaAs substrate 12 along a line to cut 5 upon radiation with laser light L which is pulsed laser light. As a consequence, the modified region 7 formed in the GaAs substrate 12 along the line to cut 5 is likely to generate fractures in the thickness direction of an object to be processed 1. Therefore, the modified region 7 having an extremely high function as a starting point region for cutting can be formed in the planar object to be processed 1 comprising the GaAs substrate 12.
US08420504B2 Method for manufacturing semiconductor device
There are provided a semiconductor device having a structure which can realize not only suppression of a punch-through current but also reuse of a silicon wafer used for bonding, in manufacturing a semiconductor device using an SOI technique, and a manufacturing method thereof. A semiconductor film into which an impurity imparting a conductivity type opposite to that of a source region and a drain region is implanted is formed over a substrate, and a single crystal semiconductor film is bonded to the semiconductor film by an SOI technique to form a stacked semiconductor film. A channel formation region is formed using the stacked semiconductor film, thereby suppressing a punch-through current in a semiconductor device.
US08420502B2 Group III-V semiconductor device and method for producing the same
A method for producing a Group III-V semiconductor device, includes forming, on a base, a plurality of semiconductor devices isolated from one another, forming, through ion implantation, a high-resistance region in a surface layer of a side surface of each semiconductor device, after formation of the high-resistance region, forming a p-electrode and a low-melting-point metal diffusion prevention layer on the top surface of the semiconductor device, bonding the semiconductor device to a conductive support substrate via a low-melting-point metal layer, and removing the base through the laser lift-off process.
US08420501B2 Transfer method of functional region, LED array, LED printer head, and LED printer
A method includes arranging a first bonding layer on a first functional region on a first substrate, or a region on a second substrate, bonding the first functional region to the second substrate through the first bonding layer, subjecting a first release layer to a first process to separate the first substrate from the first functional region at the first release layer, arranging a second bonding layer on a second functional region on the first substrate, or a region on a third substrate, bonding the second functional region to the second or third substrate through the second bonding layer, and subjecting a second release layer to a second process to separate the first substrate from the second functional region at the second release layer.
US08420495B2 Manufacturing approach for collector and a buried layer of bipolar transistor
This invention disclosed a manufacturing approach of collector and buried layer of a bipolar transistor. One aspect of the invention is that a pseudo buried layer, i.e, collector buried layer, is manufactured by ion implantation and thermal anneal. This pseudo buried layer has a small area, which makes deep trench isolation to divide pseudo buried layer unnecessary in subsequent process. Another aspect is, the doped area, i.e, collector, is formed by ion implantation instead of high cost epitaxy process. This invention simplified the manufacturing process, as a consequence, saved manufacturing cost.
US08420491B2 Structure and method for replacement metal gate field effect transistors
A structure and method for replacement metal gate (RMG) field effect transistors is disclosed. Silicide regions are formed on a raised source-drain (RSD) structure. The silicide regions form a chemical mechanical polish (CMP) stopping layer during a CMP process used to expose the gates prior to replacement. Protective layers are then applied and etched in the formation of metal contacts.
US08420480B2 Patterning a gate stack of a non-volatile memory (NVM) with formation of a gate edge diode
A gate-edge diode is made in a diode region of a substrate and a non-volatile memory cell is made in an NVM region of the substrate. A first dielectric layer is formed on the substrate in the diode region and the NVM region. A first conductive layer is formed on the first dielectric layer. A second dielectric layer is formed on the first conductive layer. A second conductive layer is formed over the second dielectric layer. A first mask is formed over the diode region having a first pattern. The first pattern is of a plurality of fingers and a second mask over the NVM region has a second pattern. The second pattern is of a gate stack of the non-volatile memory cell. An etch is performed through the second conductive layer, the second dielectric layer, and the first conductive layer to leave the first pattern of the plurality of fingers in the diode region and the second pattern of the gate stack in the NVM region. An implant is performed using the gate stack and the plurality of fingers as a mask to provide source/drain regions adjacent to the gate stack in the NVM region and diode terminals between the fingers in the diode region to form the gate-edge diode with the diode terminals and the substrate.
US08420479B2 Semiconductor device comprising a capacitor formed in the contact level
A contact level in a semiconductor device may be used for providing a capacitor that may be directly connected to a transistor, thereby providing a very space-efficient capacitor/transistor configuration. For example, superior dynamic RAM arrays may be formed on the basis of the capacitor/transistor configuration disclosed herein.
US08420476B2 Integrated circuit with finFETs and MIM fin capacitor
An integrated circuit having finFETs and a metal-insulator-metal (MIM) fin capacitor and methods of manufacture are disclosed. A method includes forming a first finFET comprising a first dielectric and a first conductor; forming a second finFET comprising a second dielectric and a second conductor; and forming a fin capacitor comprising the first conductor, the second dielectric, and the second conductor.
US08420474B1 Controlling threshold voltage in carbon based field effect transistors
A field effect transistor fabrication method includes defining a gate structure on a substrate, depositing a dielectric layer on the gate structure, depositing a first metal layer on the dielectric layer, removing a portion of the first metal layer, depositing a second metal layer, annealing the first and second metal layers, and defining a carbon based device on the dielectric layer and the gate structure.
US08420471B2 Dense pitch bulk FinFET process by selective EPI and etch
Disclosed is a method of forming a pair of transistors by epitaxially growing a pair of silicon fins on a silicon germanium fin on a bulk wafer. In one embodiment a gate conductor between the fins is isolated from a conductor layer on the bulk wafer so a front gate may be formed. In another embodiment a gate conductor between the fins contacts a conductor layer on the bulk wafer so a back gate may be formed. In yet another embodiment both of the previous structures are simultaneously formed on the same bulk wafer. The method allow the pairs of transistors to be formed with a variety of features.
US08420470B2 Method of fabricating a semiconductor device using compressive material with a replacement gate technique
The disclosed method of fabricating a semiconductor device structure forms a dummy gate structure on a substrate, deposits a dielectric material overlying the dummy gate structure in a manner that forms angled sidewalls of the deposited dielectric material outboard the spacers, and conformally deposits a compressive material overlying the deposited dielectric material such that the deposited compressive material forms angled peaks overlying the dummy gate structure. The method continues by forming an upper dielectric layer overlying the deposited compressive material, planarizing the resulting device structure, and exposing the temporary gate element of the dummy gate structure. Thereafter, the temporary gate element is removed, while leaving sections of the deposited compressive material outboard the spacers, and the gate recess is filled with a gate electrode material. The compressive material pulls the upper ends of the spacers apart to facilitate filling the gate recess.
US08420469B2 Schottky FET fabricated with gate last process
A method for forming a field effect transistor (FET) includes forming a dummy gate on a top semiconductor layer of a semiconductor on insulator substrate; forming source and drain regions in the top semiconductor layer, wherein the source and drain regions are located in the top semiconductor layer on either side of the dummy gate; forming a supporting material over the source and drain regions adjacent to the dummy gate; removing the dummy gate to form a gate opening, wherein a channel region of the top semiconductor layer is exposed through the gate opening; thinning the channel region of the top semiconductor layer through the gate opening; and forming gate spacers and a gate in the gate opening over the thinned channel region.
US08420467B2 Semiconductor device and method for manufacturing the same
A semiconductor device has a semiconductor substrate, a semiconductor fin which is formed on the semiconductor substrate, which has a long side direction and a short side direction, and which has a carbon-containing silicon film including an impurity and a silicon film formed on the carbon-containing silicon film, a gate electrode which is formed to face both side surfaces of the semiconductor fin in the short side direction, source and drain regions which are respectively formed in the semiconductor fin located in the direction of both sides in the long side direction of the semiconductor fin so as to sandwich the gate electrode, and an element isolation insulating film which is formed on the side surface of the semiconductor fin and between the gate electrode and the semiconductor substrate.
US08420466B2 Method of forming TFT floating gate memory cell structures
A device having thin-film transistor (TFT) floating gate memory cell structures is provided. The device includes a substrate, a dielectric layer on the substrate, and one or more source or drain regions being embedded in the dielectric layer. the dielectric layer being associated with a first surface. Each of the one or more source or drain regions includes an N+ polysilicon layer on a diffusion barrier layer which is on a first conductive layer. The N+ polysilicon layer has a second surface substantially co-planar with the first surface. Additionally, the device includes a P− polysilicon layer overlying the co-planar surface and a floating gate on the P− polysilicon layer. The floating gate is a low-pressure CVD-deposited silicon layer sandwiched by a bottom oxide tunnel layer and an upper oxide block layer. Moreover, the device includes at least one control gate made of a P+ polysilicon layer overlying the upper oxide block layer. A method of making the same memory cell structure is provided and can be repeated to integrate the structure three-dimensionally.
US08420463B2 Method for manufacturing pixel structure
A pixel structure includes a scan line, a data line, an active element, a first passivation layer, a second passivation layer and a pixel electrode. The data line includes a first data metal segment and a second data metal layer. The active element includes a gate electrode, an insulating layer, a channel layer, a source and a drain. The channel layer is positioned on the insulating layer above the gate electrode. The source and the drain are positioned on the channel layer. The source is coupled to the data line. The first passivation layer and the second passivation layer cover the active element and form a first contact hole to expose a part of the drain. The second passivation layer covers a part edge of the drain. The pixel electrode is disposed across the second passivation layer and coupled to the drain via the first contact hole.
US08420460B2 Method, structure and design structure for customizing history effects of SOI circuits
A design structure is embodied in a machine readable medium for designing, manufacturing, or testing a design. The design structure includes a high-leakage dielectric formed over an active region of a FET and a low-leakage dielectric formed on the active region and adjacent the high-leakage dielectric. The low-leakage dielectric has a lower leakage than the high-leakage dielectric. Also provided is a structure and method of fabricating the structure.
US08420459B1 Bulk fin-field effect transistors with well defined isolation
A fin field-effect-transistor fabricated by forming a dummy fin structure on a semiconductor substrate. A dielectric layer is formed on the semiconductor substrate. The dielectric layer surrounds the dummy fin structure. The dummy fin structure is removed to form a cavity within the dielectric layer. The cavity exposes a portion of the semiconductor substrate thereby forming an exposed portion of the semiconductor substrate within the cavity. A dopant is implanted into the exposed portion of the semiconductor substrate within the cavity thereby creating a dopant implanted exposed portion of the semiconductor substrate within the cavity. A semiconductor layer is epitaxially grown within the cavity atop the dopant implanted exposed portion of the semiconductor substrate.
US08420458B2 Semiconductor device and method of producing same
A semiconductor device has a planarizing layer that is made of an inorganic film, and has a recessed portion formed in a region thereof in which a conductive film is disposed. A first contact hole penetrating through at least an interlayer insulating film is formed on a first wiring layer, while a second contact hole penetrating through at least the interlayer insulating film is formed on the conductive film so as to run through the inside of the recessed portion.
US08420451B2 Manufacturing method of semiconductor device
Performing electrolysis plating to a wiring is made possible, aiming at the increasing of pin count of a semiconductor device. Package substrate 3 by which ring shape common wiring 3p for electric supply was formed in the inner area of bonding lead 3j in device region 3v of main surface 3a is used. Since a plurality of first plating lines 3r and fourth plating lines 3u for electric supply connected to common wiring 3p can be arranged by this, the feeder for electrolysis plating can be arranged to all the land parts on the back. Hereby, it becomes possible to perform electrolysis plating to the wiring of main surface 3a of package substrate 3, and the back surface.
US08420434B2 Solid-state imaging device and method of manufacturing solid-state imaging device
A solid state imaging device having a back-illuminated type structure in which a lens is formed on the back side of a silicon layer with a light-receiving sensor portion being formed thereon. Insulating layers are buried into the silicon layer around an image pickup region, with the insulating layer being buried around a contact layer that connects an electrode layer of a pad portion and an interconnection layer of the surface side. A method of manufacturing such a solid-state imaging device is also provided.
US08420433B2 Tiled light sensing array
A method is provided of forming a light sensing arrangement for use in a light sensor. The method comprises tiling a plurality of individual light sensing elements on a carrier, each element having a notch formed in an edge thereof, the notch being adapted to provide space, when the elements are tiled together, for an electrical connection to be made between the carrier and a surface of the element arranged to faced away from the carrier. Each element may comprise Silicon Photomultiplier (SPM) circuitry.
US08420431B2 Solar cell
A method of fabricating a solar cell includes steps of: forming an amorphous carbon layer, an AlN layer and a first n-type nitride semiconductor layer on the surface of the graphite substrate, forming a mask layer with a plurality of openings on the first n-type nitride semiconductor layer; forming a plurality of second n-type nitride semiconductor layers on the portions of the first n-type nitride semiconductor layer which are exposed by the plurality of openings; forming a plurality of light absorption layers on the plurality of second n-type nitride semiconductor layers; forming a plurality of p-side nitride semiconductor layers on the plurality of the light absorption layers; forming a p-side electrode; and forming an n-side electrode.
US08420427B2 Methods for implementation of a switching function in a microscale device and for fabrication of a microscale switch
Methods for Implementation of a Switching Function in a Microscale Device and for Fabrication of a Microscale Switch. According to one embodiment, a method is provided for implementing a switching function in a microscale device. The method can include providing a stationary electrode and a stationary contact formed on a substrate. Further, a movable microcomponent suspended above the substrate can be provided. A voltage can be applied between the between a movable electrode of the microcomponent and the stationary electrode to electrostatically couple the movable electrode with the stationary electrode, whereby the movable component is deflected toward the substrate and a movable contact moves into contact with the stationary contact to permit an electrical signal to pass through the movable and stationary contacts. A current can be applied through the first electrothermal component to produce heating for generating force for moving the microcomponent.
US08420425B2 Method for producing a group III nitride semiconductor light-emitting device
The present invention provides a method for producing a Group III nitride semiconductor light-emitting device whose driving voltage is reduced. In the production method, a p cladding layer has a superlattice structure in which a p-AlGaN layer having a thickness of 0.5 nm to 10 nm and an InGaN layer are alternately deposited. A growth temperature of the p-AlGaN layer is 800° C. to 950° C. The InGaN layer having a thickness of one to two monolayers is formed on the p-AlGaN layer, by stopping the supply of TMA, introducing TMI, and increasing the supply amount of Ga source gas while maintaining the p-AlGaN layer at the growth temperature. Thus, the thickness of the p cladding layer can be reduced while maintaining good crystal quality, thereby reducing the driving voltage.
US08420419B2 Group-III nitride semiconductor laser device, and method for fabricating group-III nitride semiconductor laser device
A method of fabricating a III-nitride semiconductor laser device includes: preparing a substrate product, where the substrate product has a laser structure, the laser structure includes a semiconductor region and a substrate of a hexagonal III-nitride semiconductor, the substrate has a semipolar primary surface, and the semiconductor region is formed on the semipolar primary surface; scribing a first surface of the substrate product to form a scribed mark, the scribed mark extending in a direction of an a-axis of the hexagonal III-nitride semiconductor; and after forming the scribed mark, carrying out breakup of the substrate product by press against a second region of the substrate product while supporting a first region of the substrate product but not supporting the second region thereof, to form another substrate product and a laser bar.
US08420417B2 Light emitting device and method of manufacture
A method of making a light emitting device includes forming an active layer between first and semiconductor layers of different conductivity types, and forming a transparent conductive layer adjacent the second semiconductor layer. The transparent conductive layer includes a first transparent conductive region contacting a first region of the second semiconductor layer and a second transparent conductive region contacting a second region of the second semiconductor layer. An electrode is formed adjacent the first semiconductor layer in vertical alignment with the second region.
US08420413B2 Method for manufacturing pixel structure
A pixel structure including a scan line, a data line, an active device, a shielding electrode, and a pixel electrode is provided on a substrate. The data line includes an upper conductive wire and a bottom conductive wire. The upper conductive wire is disposed over and across the scan line. The bottom conductive wire is electrically connected to the upper conductive wire. The active device is electrically connected to the scan line and the upper conductive wire. The shielding electrode is disposed over the bottom conductive wire. The pixel electrode disposed over the shielding electrode is electrically connected to the active device. In addition, parts of the pixel electrode and parts of the shielding electrode form a storage capacitor.
US08420410B2 Techniques providing fiducial markers for failure analysis
A semiconductor die includes a group of spacer cells within the semiconductor die. The spacer cells include fiducial markings therein. The fiducial markings can be located within a metal layer, a diffusion layer, a polysilicon layer, and/or a Shallow Trench Isolation (STI) structure.
US08420409B2 Method for manufacturing semiconductor device
An object is to provide a highly reliable semiconductor device that has tolerance to external stress and electrostatic discharge. Another object is to prevent defective shapes and defective characteristics due to the external stress or an electrostatic discharge in the manufacturing process, and to manufacture a semiconductor device with high yield. Still another object is to manufacture a semiconductor device at low cost and with high productivity. With the use of a conductive shield, electrostatic breakdown (malfunctions of the circuit or damages of a semiconductor element) due to electrostatic discharge of the semiconductor integrated circuit is prevented. The conductive shield is formed so that at least the conductive shields on the top and bottom surfaces are electrically connected by a plating method. In addition, a semiconductor device can be formed at low cost with high productivity because a plating method is used for the formation of the conductive shield.
US08420408B2 Semiconductor memory and manufacturing method thereof
A method for manufacturing a semiconductor memory device includes sequentially depositing a bottom electrode layer, a magnetic tunnel junction (MTJ) layer, a first top electrode layer, a second top electrode layer and a mask layer, etching the mask layer and forming a mask pattern, etching the second top electrode layer and the first top electrode layer by using the mask pattern as an etch barrier, etching the MTJ layer by using the mask layer and the second top electrode layer as an etch barrier, and etching the bottom electrode layer by using the first top electrode layer as an etch barrier.
US08420406B2 Method for analysing metabolites
Described is a method for analyzing the metabolites of a biological sample which comprises quantitatively determining one or more metabolites in said sample in a way that said quantitative determination resolves isotopic mass differences within one metabolite, said method being characterized in that the sample comprises or is derived from a cell which has been maintained under conditions allowing the uptake of an isotopically labeled metabolizable compound so that the metabolites in said cell are saturated with the isotope with which said metabolizable compound is labeled. This method may further comprise, prior to quantitative determining the metabolites, combining the biological sample (i.e. the first biological sample) with a second biological sample in which the metabolites are not isotopically labeled or are isotopically labeled differently from the first biological sample; and determining in said biological samples the relative quantity of metabolites which differ by their isotopical label. Furthermore described is a set of isotopically labeled metabolites obtainable by applying this method, as well as kits facilitating the application of this method and corresponding uses.
US08420395B2 Methods of unidirectional, site-specific integration into a genome, compositions and kits for practicing the same
The subject invention provides a unidirectional site-specific integration system for integrating a nucleic acid into the genome of a target cell. The provided systems include a (1) a mutant, unidirectional site specific integrase, which can be provided by an integrase vector encoding the mutant integrase and (2) a targeting vector that includes: (a) a nucleic acid to be integrated; and (b) a vector attachment site, where the targeting vector attachment site serves as a substrate for the mutant, unidirectional site-specific integrase. In using the subject systems for site-specific integration, the targeting vector and integrase are introduced into the target cell and the cell is maintained under conditions sufficient to provide for site-specific integration of the nucleic acid into the target cell genome via a recombination event mediated by the site-specific integrase. Also provided are kits that include the subject systems. The subjects systems, methods and kits find use in a variety of different applications, several representative ones of which are described in detail as well.
US08420392B2 Method for culturing human periosteum
The present invention provides a method for forcingly culturing a piece of human periosteum tissue in a shorter culture period, the method including the steps of: (1) placing a periosteum piece dissected from a patient on a culture dish containing no culture solution; (2) dropping platelet-rich plasma collected from the patient onto the surface of the periosteum piece on the culture dish and coagulating the platelet-rich plasma so as to cover the surface of the periosteum piece; (3) adding a first culture medium to the culture dish and growing the culture; and (4) growing the culture in a second culture medium containing a basic fibroblast growth factor and no platelet-rich plasma, after the step (3).
US08420391B2 RNA sequence-specific mediators of RNA interference
The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long dsRNA. Thus, these 21-23 nt fragments are the sequence-specific mediators of RNA degradation. A molecular signal, which may be their specific length, must be present in these 21-23 nt fragments to recruit cellular factors involved in RNAi. This present invention encompasses these 21-23 nt fragments and their use for specifically inactivating gene function. The use of these fragments (or chemically synthesized oligonucleotides of the same or similar nature) enables the targeting of specific mRNAs for degradation in mammalian cells, where the use of long dsRNAs to elicit RNAi is usually not practical, presumably because of the deleterious effects of the interferon response. This specific targeting of a particular gene function is useful in functional genomic and therapeutic applications.
US08420389B2 Nipah virus vaccines
The present invention relates to recombinant anti-Nipah virus vaccines and the administration of such vaccines to animals, advantageously pigs. Advantageously, the anti-Nipah virus vaccine may comprise a recombinant avipox virus containing a Nipah virus glycoprotein gene. The invention encompasses methods of vaccinating animals, advantageously pigs, by administration of anti-Nipah virus vaccines that may comprise a recombinant avipox virus that may contain a Nipah virus glycoprotein gene.
US08420386B2 Transposon-based targeting system
The present invention relates to a targeting system comprising, preferably as distinct components (a) a transposon which is devoid of polynucleotide encoding a functional transposase comprising (aa) a polynucleotide of interest and; (ab) a DNA sequence specifically recognized by a DNA binding domain; and (ba) a fusion protein comprising (i) said DNA binding domain; or (ii) a (poly)peptide binding domain binding to a (poly)peptide comprising said DNA binding domain; and (iii) a DNA targeting domain; or (iv) a (poly)peptide binding domain that binds to a cellular or engineered (poly)peptide that comprises a DNA targeting domain; or (bb) a polynucleotide encoding the fusion protein of (ba); and (ca) a transposase or a fragment or derivative thereof having transposase function; or (cb) a polynucleotide encoding the transposase or fragment or derivative thereof having transposase function of (ca).
US08420384B2 Apparatus for making a solid nutrient medium and associated method
The present invention provides an apparatus comprised of devices for simple, fast and cost-effective storage and plating of solid nutrient medium (SNM) for various uses in the field of microbiological analysis. The devices consist of a container which can be aseptically filled with SNM and equipped with a plunger to accurately press out needed amounts of the SNM; a cutting means to cut, hold and transfer SNM; a measuring means to measure the amount of SNM exiting the container; and a growth plate for storage of SNM, growth of microorganisms on SNM, and introduction of indicator substances to SNM for analysis of microorganisms.
US08420382B2 Acoustic wave biosensor for the detection and identification of characteristic signaling molecules in a biological medium
An acoustic wave biosensor comprises a plurality of spaced apart electrodes disposed on a substrate of piezoelectric material and having a biolayer matched to a specific type of autoinducer signaling molecule to be detected. The biolayer comprises a layer of heterobifunctional molecules disposed on the electrodes and on the piezoelectric material between the electrodes, and a plurality of bioreceptor molecules which bind exclusively with the specific type of autoinducer signaling molecule to be detected. The bioreceptor molecules are supported by the layer of heterobifunctional molecules, and a hydrogel layer surrounds the bioreceptor molecules to support a three-dimensional structure thereof. The bioreceptor molecules can bind with the specific type of autoinducer signaling molecule to be detected, and the biolayer is reactive thereto such that corresponding autoinducer signaling molecules bind to the biolayer and detectably vary acoustic characteristics of the acoustic wave biosensor.
US08420381B2 Apparatus and method for maintaining and/or restoring viability of organs
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
US08420379B2 Material for capturing microbes, device for capturing microbes, method of capturing microbes, and method of producing material for capturing microbes
The invention relates to a material for capturing microbes or the like, a device for capturing microbes or the like, a method of capturing microbes or the like, and a method of producing a material for capturing microbes or the like, and has an object of using a pulverizable resin whereby a minor amount of microbes or the like contained in a large amount of a liquid, or microbes or the like contained in a small amount of a liquid can be captured efficiently, quickly, labor-savingly, and reliably. Disclosed is: a material for capturing microbes or the like, which comprises irregular-shaped powdery grains made of a pulverizable adsorbent resin and distributed in a predetermined grain size range, and which can adsorb or bond to a target such as a microbe contained in a liquid; a device for capturing microbes or the like; and a method of capturing microbes or the like.
US08420377B2 Transgenomic mitochondria, transmitochondrial cells and organisms, and methods of making and using
The invention provides transgenomic mitochondria, transmitochondrial cells and organisms, and the materials and methods for making such mitochondria, cells, and organisms.
US08420375B2 Microorganisms and methods for carbon-efficient biosynthesis of MEK and 2-butanol
A non-naturally occurring microbial organism has at least one exogenous nucleic acid encoding a MEK pathway enzyme expressed in a sufficient amount to produce MEK. The MEK pathway includes an enzyme selected from an acetoacetyl-CoA dehydrogenase (bifunctional), an acetoacetyl-CoA aldehyde dehydrogenase, a 3-oxobutyraldehyde reductase, a 3-oxobutanol dehydratase, an MEK oxidoreductase, a 3-oxobutyraldehyde aminotransferase, a 4-aminobutan-2-one deaminase, a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP aminotransferase, a 2,4-dioxopentanoate decarboxylase, an AKP deaminase, an acetylacrylate decarboxylase, an AKP decarboxylase, a glutamate dehydrogenase, a 3-oxobutyraldehyde oxidoreductase (aminating) and an AKP oxidoreductase (aminating). A 2-butanol pathway further includes an MEK reductase. A method for producing MEK or 2-butanol includes culturing these organisms under conditions and for a sufficient period of time to produce MEK or 2-butanol.
US08420374B2 Helicobacter system and uses thereof
Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. In some embodiments, the Helicobacter provides exposure of a desired molecule of interest though the surface of the Helicobacter, providing exposure of the antigen to the host at the gastric mucosa. Live Helicobacter pylori vaccines are also provided. Vectors and shuttle vector constructs of the Helicobacter are also disclosed.
US08420372B2 Porcine adeno-associated viruses
Porcine tissues were screened for the presence of Adeno-Associated Viruses (AAV). Several AAV sequences were isolated from various porcine tissues, and BLAST analysis confirmed high to low homology with known AAV sequences of different origin. Sequence analysis confirmed the isolation of at least three novel porcine AAV isolates which we named AAVpo1, -po2, and -po3. Novel AAVs derived from porcine tissues may significantly contribute to the generation of new preventive or curative clinical modalities acceptable for human use.
US08420370B2 Alpha-amylase variants
The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular reduced capability of cleaving a substrate close to the branching point, and improved substrate specificity and/or improved specific activity relative to the parent alpha-amylase.
US08420368B2 Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof
This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the lysosomal sulfatase enzyme.
US08420361B2 Clostridium sporosphaeroides for the treatment of biomass
A method of treatment of biomass is described, characterized in that a microorganism of the species Clostridium sporosphaeroides is added to the biomass.
US08420358B2 Method for the combined production of butanol and hydrogen
The invention relates to a process for the combined production of butanol and hydrogen from biomass, comprising the steps of fermenting biomass to obtain butanol in a first reaction mixture; removing the butanol and hydrogen from the first reaction mixture to obtain effluent; and using the effluent as a substrate in a second reaction mixture in a process using low substrate concentrations, in particular a hydrogen production process. Preferably, the process using low substrate concentrations is a hydrogen production process and at least part of the end products of the hydrogen production process is removed from the second reaction mixture for obtaining an effluent that comprises organic acid, which effluent is returned to the first reaction mixture.
US08420357B2 Recombinant microorganism capable of producing polylactate or polylactate copolymer from sucrose and method for producing polylactate or polylactate copolymer from sucrose using the same
Provided are a microorganism capable of producing a polylactate (PLA) or PLA copolymer from sucrose and a method of producing the PLA or PLA copolymer from sucrose using the same. A gene of an enzyme converting lactate into lactyl-CoA and a gene of a polyhydroxyalkanoate (PHA) synthase using lactyl-CoA as a substrate are introduced into a microorganism capable of using sucrose as a substrate, and the microorganism is cultured using sucrose as the substrate, thereby allowing efficient production of a PLA or PLA copolymer.
US08420349B2 Enzymatic modification of oil
The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated fatty acid in an oil composition.
US08420348B2 Antibodies for the detection of integrin complexes in FFPE material
The invention relates to antibodies that are capable to bind the extracellular domain of integrin. Another object of the invention concerns the use of said antibodies for detecting integrins in archival formalin fixed paraffin embedded (FFPE) tissue. The invention also relates to methods for preparing monoclonal rabbit antibodies, wherein the immunogen is an insect expression culture-derived recombinant extracellular integrin domain, and another method for screening anti-integrin antibodies that discriminate between closest integrin homologues and that are especially suited for immunohistochemistry in FFPE material.
US08420345B2 Method for identifying at least two groups of microorganisms
The present invention relates to a method for identifying at least two groups of microorganisms expressing the same enzymatic activity, comprising the following steps: a) incubating said groups of microorganisms in a reaction medium comprising a first enzyme substrate and a second enzyme substrate, said first and second enzyme substrates being metabolized by the same enzymatic activity; b) identifying said groups of microorganisms.
US08420344B2 Fatty acid pattern analysis for predicting acute coronary syndrome
The present invention provides blood based methods for predicting risk of acute coronary syndrome in a subject.
US08420341B2 Methods for measuring ADP
This invention relates to assays for detecting and measuring ADP. In particular, this invention provides homogeneous luminescent assays that detect ADP generation and measures ADP accumulation based on enzymatic coupling reactions. The assays of the present invention can be applied to all types of kinases and other ADP-generating enzymes, are antibody free, beads free, radioisotope free, and compatible with commonly used kinase buffers.
US08420337B2 Lipoprotein-associated markers for cardiovascular disease
The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop, or is suffering from, cardiovascular disease. The methods comprise detecting an amount of at least one biomarker in a biological sample, or HDL subfraction thereof, from the subject, and comparing the detected amount of the biomarker to a predetermined value, where a difference between the detected amount and the predetermined value is indicative of the presence or risk of cardiovascular disease in the subject. In some embodiments, the biomarker comprises at least one of ApoC-IV, Paraoxonase 1, C3, C4, ApoA-IV, ApoE, ApoL1, C4B1, Histone H2A, ApoC-II, ApoM, Vitronectin, Haptoglobin-related protein, and Clusterin, or combinations thereof.
US08420336B2 Method of bioassaying yokukansan
An in-vitro bioassay method for yokukansan, involving competitively binding a labeled ligand and yokukansan with cells or cell membranes expressing glutamate receptors, measuring the binding activity of yokukansan, and determining the pharmacological activity of yokukansan from the measurement.
US08420330B2 Diagnosis and treatment of cardiac troponin 1 (cTn1) autoantibody-mediated heart disease
Provided herein are, inter alia, methods of diagnosing and treating autoimmune cardiomyopathy in subjects, based upon the detection of IgG4 autoantibodies to cardiac troponin I (cTnI).
US08420325B2 Thermostable polymerases having altered fidelity and methods of identifying and using same
The present invention provides a method for identifying a thermostable polymerase having altered fidelity. The method consists of generating a random population of polymerase mutants by mutating at least one amino acid residue of a thermostable polymerase and screening the population for one or more active polymerase mutants by genetic selection. For example, the invention provides a method for identifying a thermostable polymerase having altered fidelity by mutating at least one amino acid residue in an active site O-helix of a thermostable polymerase. The invention also provides thermostable polymerases and nucleic acids encoding thermostable polymerases having altered fidelity, for example, high fidelity polymerases and low fidelity polymerases. The invention additionally provides a method for identifying one or more mutations in a gene by amplifying the gene with a high fidelity polymerase. The invention further provides a method for accurately copying repetitive nucleotide sequences using a high fidelity polymerase mutant. The invention also provides a method for diagnosing a genetic disease using a high fidelity polymerase mutant. The invention further provides a method for randomly mutagenizing a gene by amplifying the gene using a low fidelity polymerase mutant.
US08420320B2 Method for rapid identification of microorganisms
The present invention relates, in general, to probes, methods, and kits used to determine the presence or absence of a microorganism in a sample. The probes, methods, and kits comprise at least one capture probe and/or at least one detector probe.
US08420318B2 Microfabricated integrated DNA analysis system
Methods and apparatus for genome analysis are provided. A microfabricated structure including a microfluidic distribution channel is configured to distribute microreactor elements having copies of a sequencing template into a plurality of microfabricated thermal cycling chambers. A microreactor element may include a microcarrier element carrying the multiple copies of the sequencing template. The microcarrier element may comprise a microsphere. An autovalve at an exit port of a thermal cycling chamber, an optical scanner, or a timing arrangement may be used to ensure that only one microsphere will flow into one thermal cycling chamber wherein thermal cycling extension fragments are produced. The extension products are captured, purified, and concentrated in an integrated oligonucleotide gel capture chamber. A microfabricated component separation apparatus is used to analyze the purified extension fragments. The microfabricated structure may be used in a process for performing sequencing and other genetic analysis of DNA or RNA.
US08420311B2 Method to block the infection by flaviviruses, molecules and uses
The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
US08420307B2 Sperm cryoprotective media
Described herein is a composition that comprises a cryoprotectant; a membrane protectant that stabilizes or assists in stabilization of membranes of sperm; and a free radical scavenger (e.g., a reducing agent, an antioxidant).
US08420303B2 Substrate processing method, computer-readable storage medium and substrate processing system
A PEB unit has a first heat plate and a second heat plate. After an exposure process for a resist film for EUV on a wafer and before a development process, the PEB unit heats the wafer through the first heat plate at a first heating temperature. A heating time through the first heat plate is not less than 10 seconds and not more than 30 seconds. Thereafter, the PEB unit heats the wafer through the second heat plate at a second heating temperature lower than the first heating temperature. A temperature difference between the first heating temperature and the second heating temperature is not less than 20° C. and not more than 60° C.
US08420287B2 Positive photosensitive resin composition
Disclosed is a positive photosensitive resin composition that includes: (A) a polybenzoxazole precursor including a repeating unit represented by the Chemical Formula 1, a repeating unit represented by the Chemical Formula 2, or a combination thereof, and a thermally polymerizable functional group at least one terminal end of the polybenzoxazole precursor; (B) a photosensitive diazoquinone compound; (C) a silane compound; (D) a phenol compound including a cross-linking functional group; and (E) a solvent.
US08420286B2 Toner process
The present disclosure provides processes for preparing toner particles, in which fewer coarse particles are generated. The process includes introducing a buffer solution during coalescence of the toner slurry. The amount of coarse particles in the resulting toner particles may, in embodiments, be reduced to less than about 5 percent by weight of the total toner particles generated.
US08420280B2 Hologram recording medium
The present invention provides a hologram recording medium which can attain high refractive index change, flexibility, high sensitivity, low scattering, environment resistance, durability, low dimension change (low shrinkage) and high multiplicity in holographic memory record using a blue laser. A hologram recording medium (11) comprising at least a hologram recording material layer, wherein the hologram recording material layer (21) comprises at least a metal oxide and a photopolymerizable compound; and said hologram recording medium has a light transmittance of 50% or more at a wavelength of 405 nm, or a light reflectance of 25% or more at a wavelength of 405 nm.
US08420274B2 Membrane electrode assembly for fuel cell, method of manufacturing the same, and fuel cell including the membrane electrode assembly
A membrane electrode assembly for a fuel cell, includes: an electrolyte membrane, and cathode and anode that are respectively disposed on opposing surfaces of the electrolyte membrane, wherein the anode comprises an anode catalyst layer, an anode micro-porous layer and an anode diffusion support that are sequentially disposed on one surface of the electrolyte membrane, wherein the thickness ratio of the anode catalyst layer to the anode micro-porous layer is in a range of 1:0.82 to 1:3.28, and the thickness ratio of the anode catalyst layer to the anode diffusion support is in a range of 1:5 to 1:7.05.
US08420270B2 Fuel cell system
A fuel cell system capable of restraining temperature change in a fuel cell caused by a refrigerant. The fuel cell system has a refrigerant circulating system for circulating the refrigerant. The refrigerant circulating system has flow control means for restraining the inflow of the refrigerant, which has a predetermined difference in temperature from that of the fuel cell, into the fuel cell.
US08420265B2 Electrolyte for rechargeable lithium battery and rechargeable lithium battery including the same
Disclosed is an electrolyte for a rechargeable lithium battery that includes a lithium salt, a phosphine compound having at least one trialkylsilyl group and organic solvent, and a rechargeable lithium battery including the electrolyte. The phosphine compound may be tris(trialkylsilyl)phosphine wherein the alkyl groups are the same or different and are each independently selected from C1 to C6 alkyl.
US08420262B2 Nonaqueous electrolyte battery, battery pack and vehicle
A nonaqueous electrolyte battery includes a negative electrode and a positive electrode. The negative electrode includes a negative electrode current collector and a negative electrode active material having a lithium ion absorption potential of 0.4 V (vs. Li/Li+) or more. The negative electrode current collector is made of aluminum or an aluminum alloy. The positive electrode includes a positive electrode current collector and a positive electrode active material. The positive electrode current collector has a total area and specific capacitance larger than those of the negative electrode current collector, and is made of aluminum or an aluminum alloy.
US08420261B2 Thin film alloy electrodes
Thin film alloy electrodes are provided that are useful as negative electrodes in lithium-ion electrochemical cells. The alloys include aluminum and at least one additional electrochemically active metal or composite. They can be used as a current collector or as a complete electrode.
US08420257B2 Cap assembly comprising gasket prevented from sagging and cylindrical secondary battery comprising the same
A cap assembly is provided. The cap assembly comprises a main gasket surrounding the outer circumference of a safety vent and an auxiliary gasket surrounding the outer circumference of a current interrupt device (CID). The main gasket is supported by the auxiliary gasket, leaving no space between the main gasket and the safety vent. The cap assembly is constructed such that the auxiliary gasket prevents the main gasket seated on a beading portion from sagging. This construction makes the cap assembly effective in preventing an electrolyte from leaking. Further provided is a cylindrical secondary battery comprising the cap assembly.
US08420254B2 End cover assembly for an electrochemical cell
An end cover assembly for a battery comprises a cover plate; a scabbard mounted on the cover plate; a connector; and a sealing material. The cover plate comprises an opening. The scabbard comprises an interior channel. The opening is in communication with the channel. The connector is disposed in the interior channel and protrudes from the scabbard. The sealing material is disposed in the interior channel and extends beyond the upper portion of the scabbard and wraps around the outside of the scabbard to form a protective flange.
US08420252B2 Battery layout incorporating full metal edge seal
A first current collector on the first surface of the substrate and a second current collector having a first surface and a perimeter. One of the first and second current collector is an anode current collector and the other is a cathode current collector. The battery also comprises a cathode material having a perimeter, the cathode material being located on the cathode current collector; an electrolyte layer having a perimeter, the electrolyte separating the cathode material from the anode current collector; an insulation layer having a perimeter, the insulation layer together with the electrolyte layer separating the anode current collector from the cathode material and the cathode current collector. A first passivation layer generally overlies at least the perimeter of the cathode material, the perimeter of the electrolyte, and the perimeter of the insulation layer, the first passivation layer being electrically coupled to the first current collector and forming a continuous metal to metal seal around a defined area of the first current collector. The first passivation layer has a via opening. A second passivation layer is electrically coupled to the second current collector through the via opening of the first passivation layer.
US08420250B2 Battery module and battery pack including the same
A battery module and battery pack, the battery module including a pair of end plates facing each other; a plurality of battery units arranged in a first direction between the end plates; a first side plate extending along a first side of the plurality of battery units, the first side plate being coupled to the end plates; a second side plate extending along a second side of the plurality of battery units, the second side plate being coupled to the end plates and being disposed opposite to the first side plate; a first coupling member, the first coupling member coupling the end plates to the first side plate; and a second coupling member, the second coupling member coupling the end plates to the second side plate, wherein the first coupling member and the second coupling member are disposed in asymmetrical positions with respect to a central line of the end plates.
US08420247B2 Crosslinking polymer-supported porous film for battery separator and use thereof
The present invention relates to a crosslinking polymer-supported porous film for battery separator, including: a porous film; and a crosslinking polymer supported on the porous film, the crosslinking polymer having a plurality of cation-polymerizable functional groups in the molecule thereof and having oxyalkylene groups represented by general formula (I): in which the Rs may be the same or different and each independently represent a hydrogen atom or a methyl group, and n represents an integer of 4 to 9, in a side chain thereof.
US08420246B2 Electronic device with sliding battery cover
An electronic device with sliding battery cover includes a housing, a battery holder formed in the housing, a fixing element rotatably connected to the battery holder, and a battery cover slidably connected to the fixing element to cover or uncover the battery holder. The battery holder is for placing at least one battery. The fixing element includes at least one conductive elastic element. When the battery cover covers the battery holder, each conductive elastic element contacts an electrode of one of the at least one battery placed in the battery holder, and the battery cover is locked to the battery holder; when the battery cover is to uncover the battery holder, a force applied to the battery cover makes the battery cover slide along the fixing element to unlock the battery cover from the battery holder.
US08420244B2 Battery pack configured for enhanced operation in a cold environment
A battery pack includes a battery compartment, a terminal plate positioned within the battery compartment for retaining at least two batteries within the battery compartment, and a cover for enclosing the battery compartment, wherein, upon enclosing the battery compartment with the cover, the cover is configured to urge an exterior surface of one of the at least two batteries against an exterior surface of another of the at least two batteries to establish both physical and thermal contact between the at least two batteries.
US08420242B2 Cell module
A cell module has a cell group with a plurality of cells connected to each other. The module comprises a bus bar plate including a bus bar connecting between the cells and an end cover for covering the bus bar plate. The cell module is configure to be fixed with the end cover.
US08420236B2 Magnetic semiconductor material
A magnetic semiconductor material contains at least one type of transition metals (Mn2+, Fe3+, Ru3+, Re2+, and Os3+) having five electrons in the d atomic orbital as a magnetic ion, in which the magnetic semiconductor material exhibits n-type electrical conduction by injection of an electron carrier and p-type electric conduction by injection of a hole carrier. A specific example is a layered oxy-pnictide compound represented by LnMnOPn (wherein Ln is at least one type selected from Y and rare earth elements of La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu, and Pn is at least one selected from pnicogen elements of N, P, As, Bi, and Sb). A high-sensitivity magnetic sensor, current sensor, or memory device can be made by using a magnetic pn homojunction structure made of thin films composed of the magnetic semiconductor material.
US08420232B2 Binaphthyl-arylamine polymers
Disclosed are Binaphthyl-Arylamine Polymers having Formula I: In the Formula: Ar1 is an arylene; Ar2 is an aryl group; Ar3 is an arylene; Binap is a binaphthyl moiety; M is a conjugated moiety; and x, y and z are mole fractions such that x+y+z=1.0, with the proviso that x and y are not zero.
US08420227B2 Composite material, light emitting element and light emitting device
An object of the present invention is to provide a composite material formed of an organic compound and an inorganic compound, and has an excellent carrier transporting property, an excellent carrier injecting property to the organic compound, as well as excellent transparency. A composite material of the present invention for achieving the above object is a composite material of an organic compound represented in the general formula below, and an inorganic compound. For the inorganic compound, an oxide of a transition metal, preferably an oxide of a metal belonging to groups 4 to 8 of the periodic table, in particular vanadium oxide, tantalum oxide, molybdenum oxide, tungsten oxide, rhenium oxide, and ruthenium oxide, can be used.
US08420226B2 Welded structural member and method and use thereof
A structural member comprising at least two aluminum alloy parts displaying different property balances, said at least two parts being welded and wherein one of said parts either is (i) selected from an aluminum alloy different from the other of said at least two parts and/or (ii) is selected from an initial temper different from the other of said at least two parts, and wherein at least one of said at least two parts has been pre-aged prior to being welded, and, wherein said structural member has undergone a post-welding thermal treatment conferring a final temper to each of said at least two parts. The parts are advantageously welded by friction stir welding. Another subject of the invention is a method for manufacturing a structural member.
US08420220B2 Rubber composition
A rubber composition comprising 0.3 to 10 parts by mass of sulfur and 0.1 to 10 parts by mass of a sulfeneamide base vulcanization accelerator represented by the following Formula (I) based on 100 parts by mass of a rubber component: (wherein R1 to R10 are a hydrogen atom, a linear alkyl group having 1 to 4 carbon atoms or a branched alkyl group having 3 to 4 carbon atoms, and they may be the same or different; R11 is a hydrogen atom, a linear alkyl group having 1 to 10 carbon atoms or a branched alkyl group having 3 to 10 carbon atoms; R12 to R15 are a hydrogen atom, a linear alkyl group or alkoxy group having 1 to 4 carbon atoms or a branched alkyl group or alkoxy group having 3 to 4 carbon atoms, and they may be the same or different; and x represents an integer of 1 or 2).
US08420218B2 Photovoltaic modules having reduced weight
The construction principles according to the present invention make possible large sheet-like solar modules with low weight, which have great mechanical toughness, are inured to rough climatic environment influences and withstand thermal stress due to solar irradiation and shadowing effects. The solar modules have front and back panes, one of which has a thickness of at least 3 mm and the other of which has a thickness of at most 2 mm. The coefficient of thermal expansion of the thicker pane is preferably greater than that of the thinner pane. In preferred embodiments burling or a wavy structure is provided on one side of the front pane and/or the back pane.
US08420217B2 Elastic bonding films
Elastic bonding films that include an elastic, thermoset core layer and a thermoplastic bonding layer on each side of the core layer are described. The thermoset core layer is a polyurethane formed as the reaction product of (i) a multifunctional isocyanate with (ii) a combination of polyols comprising (a) polyester diol, (b) crosslinker, and (c) hard segment. Articles incorporating such elastic bonding films including fabrics bonded to such films are also described.
US08420216B2 Thermosetting resin composition
The thermosetting resin composition according to the present invention includes a resin (A) containing two or more carboxyl groups and having a polyurethane structure, a strongly basic nitrogen-containing heterocyclic compound having pKa of 10.0 to 14.0 as a curing accelerator (B) and a curing agent (C). A cured product of the thermosetting resin composition is used as an insulating protective film for printed wiring boards, flexible printed wiring boards, chip-on-films, etc. The thermosetting resin composition of the invention has improved low-temperature curability and instantaneous curability, can realize tack-free property, can simultaneously realize low warpage property and electrical insulation property, does not contaminate a curing oven and the like by outgassing during heating, has a sufficient pot life, can form excellent cured products and insulating protective films, and can form solder resists and insulating protective films at low cost with good productivity.
US08420215B2 Cyclic process for the preparation of barium sulphate and lithium metal phosphate compounds
A cyclic process for the preparation of barium sulphate and lithium-iron phosphate comprising (i) preparing an aqueous solution containing lithium and sulphate ions and (ii) adding solid barium hydroxide at a temperature of more than 50° C., wherein the barium hydroxide is added over a period of less than 15 minutes. Also, barium sulphate obtainable by the process according to the invention.
US08420214B2 Acrylic pressure-sensitive adhesives with aziridine crosslinking agents
A pre-adhesive composition is described comprising an acid-functional (meth)acrylate copolymer and an aziridine crosslinking agent, which when crosslinked provides a pressure-sensitive adhesive and pressure-sensitive adhesive articles.
US08420213B2 Composite substrate and method for forming metal pattern
A composite substrate is a piezoelectric substrate that is transparent to light used for photolithography, and a supporting substrate for supporting the piezoelectric substrate are bonded together via an organic adhesive layer. Where at least one of the supporting substrate and the organic adhesive layer of the composite substrate absorbs light used for photolithography.
US08420212B2 Silane coupling agents with heat resistance, durability, releasability and antifouling property, and process for producing these compounds
Silane coupling agents which are high in heat resistance, and which are high in durability, releasability, and antifouling properties. The silane coupling agents have a biphenylalkyl group and are represented by the following general formula (1).
US08420211B2 Porous polyimide membrane and process for production of same
Disclosed is a porous polyimide membrane of a three-layer structure having two surface layers (a) and (b) and a macrovoid layer interposed between the surface layers (a) and (b), wherein the macrovoid layer has a partition wall joined to the surface layers (a) and (b) and plural macrovoids surrounded by the partition wall and the surface layers (a) and (b), with an average void diameter in a membrane plane direction of from 10 to 500 μm; each of the partition wall of the macrovoid layer and the surface layers (a) and (b) has a thickness of from 0.1 to 50 μm and has plural pores having an average pore diameter of from 0.01 to 5 μm, the pores being communicated with each other and also communicated with the macrovoids; and the membrane has a total membrane thickness of from 5 to 500 μm and a porosity of from 70 to 95%.
US08420203B2 Surface structure for a working device
The present invention relates to a surface structure for a working device. In particular, the invention relates to a surface structure for a working device that has at least one first element with a first height and a second element with a second height, and a third element having a third height, wherein the second height is greater than the third height, having in addition a first grip area, a second grip area, and a third grip area, wherein the elements are arranged on a dot matrix, wherein the centers of the second elements and the centers of the third elements are arranged on the points of intersection and the centers of the first elements are not arranged on the points of intersection, and the first grip area comprises first elements and second elements, the second grip area comprises predominantly second elements, the third grip area comprises predominantly third elements. The present invention also relates to a working device having such a surface structure.
US08420194B2 Rotomoulded articles prepared with polyethylene
The present invention is concerned with rotomoulded articles having very low warpage and shrinkage and consisting essentially of polyethylene prepared with a catalyst system based on a bis-indenyl or on a bis(n-butyl-cyclopentadienyl)metallocene component.
US08420192B2 Silica container and method for producing the same
A method for producing a silica container comprising: forming a preliminarily molded substrate, wherein a first powdered raw material is fed to an inner wall of an outer frame having aspiration holes while rotating the outer frame; forming a preliminarily molded intermediate layer, wherein a second powdered raw material added with an aluminum compound or a crystal nucleating agent as an additive is fed to an inner wall of the preliminarily molded substrate; and forming an inner layer, wherein the preliminarily molded substrate and the preliminarily molded intermediate layer are degassed by aspiration from a peripheral side with heating from an inside thereby forming a substrate and an intermediate layer, and while a third powdered raw material having a high silica purity is spread from inside the substrate having the formed intermediate layer with heating from the inside thereby forming an inner layer on an inner surface of the intermediate layer.
US08420190B2 Packaging material for packaging of container having photosensitive composition filled therein
A packaging material for packaging a container having a photosensitive composition filled therein, which comprises a film having a transmittance of a light in a wavelength range of 200 nm to 500 nm of 5% or less and a transmittance of a light in a wavelength range of 620 nm to 940 nm of 10% or more.
US08420187B2 Cellulose acylate composition, cellulose acylate film, and its applications
A novel cellulose acylate composition is disclosed. The composition comprises at least one cellulose acylate having an aromatic group-containing acyl group (Substituent A), in which a substitution degree with Substituent A satisfies following relational expressions (I) and (II): DSA2+DSA3−DSA6>0.05,  (I) 0.11
US08420186B2 Method and apparatus of growing a thin film
A method and apparatus of growing a thin film are provided. The method comprises at least (a) providing a number of substrates; (b) cleaning the substrates; and (c) placing the substrates into a reaction liquid; (d) vibrating the reaction liquid by ultrasonic waves such that a thin film is grown on the substrates evenly.
US08420184B2 Method for preparing surface modification coating of metal bipolar plates
A method for preparing a surface modification coating of metal bipolar plates is disclosed, which comprises the following steps: providing a substrate; pre-treating the substrate by processing the substrate, depositing a Ni-layer on the substrate, or a combination thereof, to form an activated layer on the surface of the substrate; packing the substrate in a powder mixture containing a permeated master metal, an activator, and filler powder; and heat-treating the packing to allow the permeated master metal to diffuse into the activated layer and then to form a surface modification coating. The permeation rate of the permeated master metal can be increased due to the activated layer having a high defect concentration. Hence, it is possible to prepare a surface modification coating at a low temperature. The surface modification coating of the present invention can also decrease the interface contact resistance between the bipolar plates and gas diffusion layers.
US08420182B2 Method of manufacturing polymer dispersed liquid crystal display device including dichroic dye
Example embodiments relate to a method of manufacturing a polymer dispersed liquid crystal (PDLC) display device including dichroic dye. The method may include filling a mixture solution including liquid crystals, a photopolymerizable material, dichroic dyes, and liquid crystalline polymers in a space between a first electrode and a second electrode that face each other; applying an electric field between the first electrode and the second electrode; and arranging the dichroic dyes in the mixture solution.
US08420181B2 Method of producing microfluidic devices based on a polymer
Disclosed is a method for producing a polymer-based microfluidic device, including: forming a microstructure on a lower polymer matrix; coating the lower polymer matrix with TiO2 to perform patterning of TiO2; bonding the lower polymer matrix with an upper polymer matrix; and radiating UV lights thereto to convert TiO2-coated regions into hydrophilic regions. Disclosed also is a polymer-based microfluidic device obtained by the method. The method enables development of a microfluidic device having high stability and long-term durability.
US08420180B2 Electrostatic spray for coating aircraft engine components
Electrostatic deposition of high performance powdered materials onto gas turbine surfaces. The process also includes post-deposition thermal staging of the deposited powder to provide a durable coating that will satisfy the demands of turbine engine operation. The process envisions application of organic-based powdered materials, glass/ceramic powdered materials and metal-based powdered materials and combinations thereof using electrostatic techniques to components exposed to low temperature operations, such as may be found in the front section of a gas turbine engine or to the exterior portions of an aircraft engine, and metal-containing glass ceramics, glass-ceramic materials, or materials that can be transformed into glass ceramic materials, when applied to components exposed to high temperature operations, such as may be found in the turbine and exhaust sections of a gas turbine engine or the flaps of an aircraft.
US08420178B2 Liquid sending method and system
A liquid sending method comprises the steps of sending a coating solution to a liquid sending pipe, passing the coating solution to an orifice which is provided at a part of the liquid sending pipe to prevent a vibration propagation and passing the coating solution to a pulsation absorb device which is provided at a part of the liquid sending pipe where is located at a downstream of the orifice, wherein the pulsation absorb device includes a first chamber that a liquid can flow in and out, a second chamber which is introduced a gas, and a diaphragm which separates the first chamber and the second chamber.
US08420177B2 Method for preparing functional multilayer anisotropic conductive adhesive film
A functional multilayer anisotropic conductive adhesive film, capable of bonding and package 0.18-0.13 micron IC chips and high density COF, includes a monomer layer, a reinforcing layer, a low-temperature, hot-melt resin layer, and a conductive particle layer, successively bonded by coating and drying processes. The monomer layer comprises a copolymer of butyl acrylate, methyl acrylate, glycol acrylate, and tetramethyl butyl peroxy-2-ethyl hexanoate. The reinforcing layer comprises long chain imidazole derivatives. The hot-melt resin layer comprises polymer of tocopheroxyl, novolac epoxy, acrylic rubbers and elastic mixture of acrylic rubbers and styrene-butadiene rubbers. The conductive particle layer comprises conductive particles and micro-encapsulating resin for receiving the conductive particles. Diameter of the conductive particles is selected from the group consisting of 3.00 μm ±0.05, 3.25 μm±0.05, 3.50 μm±0.05, 3.75 μm±0.05 and 4.00 μm±0.05.
US08420172B1 Apparatus and method of manufacturing shingles from cellular polyvinyl chloride
A method for forming shingles from cellular polyvinyl chloride boards comprising brushing, parting, cutting and coating the boards to desired dimensions and finish. The method comprises passing cellular polyvinyl chloride boards through one or more of a specially designed brushing assembly, cross cut saw assembly, parting assembly, and sizing saw assembly, wherein the assemblies are in-line. The method may further include an in-line, high speed application and accelerated curing of a uniquely formulated solar reflective, ceramic-based finish.
US08420171B2 Forming heaters for phase change memories
A heater for a phase change memory may be formed by depositing a first material into a trench such that the material is thicker on the side wall than on the bottom of the trench. In one embodiment, because the trench side walls are of a different material than the bottom, differential deposition occurs. Then a heater material is deposited thereover. The heater material may react with the first material at the bottom of the trench to make Ohmic contact with an underlying metal layer. As a result, a vertical heater may be formed which is capable of making a small area contact with an overlying chalcogenide material.
US08420169B2 Method of manufacturing organic thin film
A thin film of a uniform film thickness is formed even without increasing the film deposition rate. The temperature of an evaporation device disposed in an evaporation chamber is raised in advance, and an organic material is dropped from a supply unit onto an evaporation surface of the evaporation device; and when the organic material is evaporated, a heated carrier gas is introduced into the evaporation chamber, and is mixed in the evaporation chamber and is introduced into a discharger. While a molecular flow is formed in the discharger in a case that only the organic material vapor is introduced into the discharger, the pressure within the discharger is raised due to the carrier gas, so that a viscous flow is formed and the mixed gas is filled in the discharger and is uniformly discharged. The organic material may be supplied by a small amount and the film deposition rate may not become too high.
US08420167B2 Method of manufacturing a semiconductor device
A method of manufacturing a semiconductor device includes the steps of: conveying a plurality of substrates disposed in a direction perpendicular to a substrate processing surface into a processing chamber provided inside of a reaction tube, with an outer periphery surrounded by a heating device; and processing the substrates by introducing gas to a gas inlet tube provided on a side face of the reaction tube in a region for processing the substrates inside the reaction tube, so as to reach at least an outside of the heating device, and spouting the gas into the processing chamber from a slit-shaped gas spouting port disposed in a form so as to straddle at least a plurality of the substrates in a direction perpendicular to the substrate processing surface.
US08420164B2 Solid type rubber-based pressure-sensitive adhesive composition and pressure-sensitive adhesive sheet thereof
The present invention relates to a solid type rubber-based pressure-sensitive adhesive composition, which is prepared by adding a tackifier, a softener, and an isocyanate-based crosslinking agent reactable with active hydrogen into an acrylic rubber containing a monomer having an active hydrogen-containing functional group as a copolymerization component to thereby obtain a solventless and nonaqueous pressure-sensitive adhesive composition, and particularly it relates to a solid type rubber-based pressure-sensitive adhesive composition having the above-mentioned constitution, in which the above-mentioned acrylic rubber includes a copolymer containing butyl acrylate as a main component, and as the copolymerization component a monomer having a hydroxyl group or a carboxyl group as the active hydrogen-containing functional group.
US08420162B2 Method of making coated article using rapid heating for reducing emissivity and/or sheet resistance, and corresponding product
This invention relates to a method of making a coated article for use in insulating glass (IG) window units, vehicle windows, or the like. The coated article typically includes a low-E coated article, including a low-E (low emissivity) coating supported by a glass substrate. In certain example embodiments, rapid heating (not sufficient for tempering or heat bending) of the coated article is utilized in order to reduce the emissivity and/or sheet resistance of the coated article without significantly damaging the infrared (IR) reflecting layer(s) of the coating, thereby activating the coated article. The glass of the coated article does not become too hot during such rapid heating.
US08420161B2 Method for producing anti-glare film
A method for producing an anti-glare film includes applying a coating composition including at least a resin, a solvent, and fine particles to a substrate; drying the coating composition applied to the substrate so that a Benard cell structure is formed in the surface of the coating layer due to convection caused during volatilization of the solvent; and curing the resin contained in the coating composition having formed therein a Benard cell structure to form an anti-glare layer having fine irregularities with a moderate surface waviness. The anti-glare layer has a degree of white muddiness of 1.7 or less, as measured by quantitatively determining a diffuse reflection component of the diffused light incident upon the surface of the anti-glare layer.
US08420160B2 Method for producing sintered NdFeB magnet
The present invention provides a method for producing a sintered NdFeB magnet having high coercivity and capable of being brought into applications without lowering its residual magnetic flux density or maximum energy product and without reprocessing. The method for producing a sintered NdFeB magnet according to the present invention includes applying a substance containing dysprosium (Dy) and/or terbium (Tb) to the surface of the sintered NdFeB magnet forming a base body and then heating the magnet to diffuse Dy and/or Tb through the grain boundary and thereby increase the coercivity of the magnet. This method is characterized in that: (1) the substance containing Dy or Tb to be applied to the surface of the sintered NdFeB magnet is substantially a metal powder; (2) the metal powder is composed of a rare-earth element R and an iron-group transition element T, or composed of R, T and another element X, the element X capable of forming an alloy or intermetallic compound with R and/or T; and (3) the oxygen content of the sintered NdFeB magnet forming the base body is 5000 ppm or lower. The element T may contain nickel (Ni) or cobalt (Co) to produce an anticorrosion effect.
US08420159B2 Method of fabricating magnetic head slider including partial removal step of protecting film
The method of fabricating a magnetic head slider includes steps of: forming a first protective film on an air bearing surface of a magnetic head slider on which either a recording element or a reproduction element is formed or on which both a recording element and a reproduction element are formed; removing a portion of the first protective film to reduce the thickness of the first protective film and forming a second protective film over the first protective film that has been reduced in thickness; and forming an uneven portion for controlling the flying characteristics of the magnetic head slider on the air bearing surface of the magnetic head slider; wherein the formation of the uneven portion is carried out after the first protective film has been formed and before the second protective film is formed, or after the second protective film has been formed.
US08420157B2 Electroluminescent device
An electroluminescent device comprises a hole injecting electrode, an electron injecting electrode and at least one organic light emitting layer disposed between said hole injecting electrode and said electron injecting electrode wherein a layered metal chalcogenide layer is disposed between said hole injecting electrode and said light emitting layer.
US08420156B2 Method of forming pattern and manufacturing method of organic light emitting device
A method of forming a pattern and a method of manufacturing an organic light emitting device, the method of forming a pattern including providing an electromagnetic substrate for generating an electromagnetic field at a selectively controllable position by selectively controlling where current flows through the electromagnetic substrate; providing a patterning substrate for forming a pattern; aligning the electromagnetic substrate to a first surface of the patterning substrate; selectively applying current to the electromagnetic substrate to form the electromagnetic field at the predetermined position; providing masking powder in a vicinity of a second surface of the patterning substrate such that the masking powder reacts to the electromagnetic field; supplying a pattern forming material to the second surface of the patterning substrate; and cutting off the current to the electromagnetic substrate.
US08420154B2 Method of manufacturing glass substrate and information recording medium
In a method of manufacturing a glass substrate for an information recording medium including a step for chemically strengthening the glass substrate by contacting the glass substrate with chemical strengthening processing liquid containing chemical strengthening salt, concentration of Fe and Cr is 500 ppb or less in said chemical strengthening salt, respectively. The concentration may be detected by the use of an ICP (Inductively Coupled Plasma) emission spectrometry analyzing method or a fluorescent X-ray spectroscopy analyzing method.
US08420148B2 Beverage whitening composition and method
A beverage whitening composition for replacing cream or milk in a reduced volume comprising: cream having a higher butter fat content than the cream or milk to be replaced; milk having a lower butter fat content than the cream or milk to be replaced; and serum solids, such as skim milk powder. The composition has the beverage whitening ability of the cream or milk to be replaced in a target volume of from 30% to 95% of the volume of cream or milk to be replaced. The composition is formulated so that from 300 mL to 950 mL of the composition has the whitening ability of 1 liter of the cream or milk to be replaced. The composition is useful for replacing conventional coffee cream in dispensers containing bags of cream so as to reduce frequency of bag replacement.
US08420145B2 Isosorbide derivatives and their use as flavor modifiers, tastants, and taste enhancers
The present invention provides isosorbide derivatives having the formula shown below and certain subgenera or species thereof, as flavor or taste modifiers, particularly, savory (“umami”) taste modifiers, savory flavoring agents and savory flavor enhancers in foods, beverages, and other comestible compositions,
US08420142B2 Food and beverage preservative
Non-toxic, naturally derived, preservative compositions for beverage products, food products and other consumer products which include d-limonene, natural wax and monohydric alcohol are provided. Methods for manufacturing such preservative compositions are also provided. In addition beverage products, food products and other consumer products which include preservative compositions comprising d-limonene, natural wax and monohydric alcohol are provided.
US08420141B2 Prevention of synthetic color fading in beverages using botanically derived color stabilizers
Fading of synthetically colored beverages is prevented using botanically derived color stabilizers which are C6-C3 phenylpropenoic carbonyl compounds which contain both (i) unsaturation and (ii) oxidation at a carbon atom.
US08420140B2 Galvanic package for fruits and vegetables and preservation method
A package for fruits and vegetables having galvanic functionality is formed by using two or more metals with different galvanic activity properties on the surface of a nonmetallic substrate. The metals may be deposited electrolytically, by vacuum, autocatalytically, or by other methods. The metals are selected to create a galvanic reaction after the package is filled with a low pH food product and its associated liquids, juices, brine, etc. The package may extend the shelf-life of the food product contained therein, for example, by making metal ions available to the food product.
US08420139B2 Capsule for infusion beverages
The invention relates to a capsule and a device for preparing an infusion beverage, such as coffee, tea, or milk beverages. The capsule comprises two parallel extending wall sections, which are connected to each other by a sealing connection. A pressurized liquid or gaseous medium can be conducted through an access to the sealing connection of the capsule with the aid of a supply line in a holder of the device such that the sealing connection is partially undone. As a result, an opening is produced in the capsule. An infusion fluid can be conducted through the opening, wherein the fluid can then become mixed with a powder or granules present in the capsule into an infusion beverage. The infusion beverage can be discharged through a further opening.
US08420137B2 Bioactive composition for cosmetic applications
The invention relates to a process for the preparation of a plant extract from Curcuma plants, characterized by the process steps process step A) liquid extraction of Curcuma rhizomes, process step B) optionally, separation of a curcuminoid-containing solid obtained by precipitation from the extraction mixture obtained in process step A), process step C) removal of solvents present from the extraction mixture obtained in process step A) or B) to obtain a concentrate and process step D) distillation of the concentrate at a pressure of less than 1 bar to give the extract as distillate.
US08420136B2 Herbal preparation for anemia and a manufacture method thereof
A herbal extract for anemia is obtained by a process including steps of drying, by providing a herbal material comprising dry mulberry and dry Acanthopanax senticosus in a weight ratio of 2:1 to 1:2, with the water content of the herbal material lower than 10%; extracting, by soaking the herbal material into a solvent to obtain a liquid extract, with the weight ratio between the herbal material and the solvent being 1:10 to 1:5; and condensation, by condensing the liquid extract to obtain a herbal extract.
US08420134B2 Herbal medicinal composition and extract thereof for inhibiting growth of cancer cells
The present invention relates to herbal medicinal compositions and extracts thereof for inhibiting growth of cancer cells. One of the examples described in the present invention comprises Forsythiae fructus, Menthae Herba, Gardeniae Fructus, Scutellariae Radix, Lophatheri Folium, Glycyrrhizae Radix, Rhei Rhizoma, Na2SO4, and Atractylodis Rhizoma . The residual examples are described herein.
US08420133B2 Modified pectins, compositions and methods related thereto
The present invention provides compositions of modified pectin and methods for preparing and using them.
US08420122B2 Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same
The present invention provides a method of continuous precipitation and isolation of an amorphous solid particulate form of 3-[2-(3-tert-Butyl-ureido)-3,3-dimethyl-butyryl]-6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylic acid (2-carbamoyl-1-cyclobutylmethyl-2-oxo-ethyl)-amide having controlled physical properties. The present invention provides also pharmaceutical formulations comprising the precipitated compound.
US08420120B2 Oral drug delivery system
Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
US08420113B2 Biodegradable medical devices with enhanced mechanical strength and pharmacological functions
The present invention is directed to a medical device, specifically a prosthesis which utilizes a novel class of blends between biodegradable polymers and bioceramics for medical device applications allowing one to capitalize on the biodegradable nature of these two distinct materials while enhancing the strength of these devices through the addition of various amounts of bioactive ceramic and glasses to biodegradable polymers. The blend may be fabricated into a medical device such as a stent or a distal protection device, and may incorporate various agents to enhance radioapacity and/or pharmacological function. In addition, the blend may be used as a coating to a medical device.
US08420111B2 Method and kit for reducing the symptoms of peripheral vascular disease
A method for reducing the symptoms of peripheral vascular disease and for improving peripheral circulation wherein a progestin is administered to a subject in need thereof.
US08420107B2 Peptide vaccines against group A streptococci
This invention, in one aspect, relates to synthetic immunoreactive peptides. These peptides are approximately 20-25 amino acids in length which are portions of the N termini of the M proteins of the most prevalent United States (U.S.) Group A Streptococcus (GAS) serotypes. At least some of the synthetic peptides can be recognized by M type-specific antibodies and are capable of eliciting functional opsonic antibodies and/or anti-attachment antibodies without eliciting tissue cross-reactive antibodies. In another aspect, it relates to compositions or vaccines comprising these synthetic serotype-specific peptides, including polypeptides and proteins. The invention may also be isolated antibodies which are raised in response to the peptides, compositions or vaccines. The invention further relates to kits for using the peptides, compositions, or antibodies. In still further aspects, the invention also relates to methods for using the peptides, compositions, vaccines, or antibodies and methods for tailoring vaccines.
US08420105B2 Botulinum toxin administration to treat various conditions
Methods for treating conditions in an animal or human subject. The conditions may be pain, skeletal muscle conditions, smooth muscle conditions, glandular conditions and cosmetic conditions. The methods comprise the step of administering a Clostridium neurotoxin component or Clostridium neurotoxin component encoding DNA to the subject using a needleless syringe.
US08420100B2 Tumor suppressor activating polypeptides and uses thereof
Chimeric tumor suppressor activating peptides derived from matrix attachment region binding protein (MARBP) SMARI unique in their sequence comprising a arginine rich motif flanked by serine residues wherein from the stretch of four consecutive serine residues the first serine residue gets phosphorylated by the protein kinase C family of serine threonine kinases being indispensable for its functionality, the phosphorylation being directly correlated to the phosphorylation of p53 at serine 15 residue thereby stabilizing it, wherein the peptide activates p53 by modifying it post translationally which allow phosphorylation and translocation of p53 to the nucleus.
US08420096B2 Cell-penetrating SOCS polypeptides that inhibit cytokine-induced signaling
Disclosed are compositions and methods related to cell-penetrating suppressor of cytokine signaling (SOCS) proteins that inhibit cytokine-induced signaling.
US08420095B2 Antigen-containing microspheres for the treatment of allergies
Microspheres containing antigens for allergy therapy, the microspheres having a binding constant of 1×104 M−1 toward a specific carbohydrate residue of intestinal and/or nasal epithelial cells.
US08420093B2 Anti-ADDL monoclonal antibody and use thereof
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
US08420092B2 Method of treating diabetes by administering an anti-NKp46 antibody
The invention relates to use of the natural cytotoxicity receptor NKp46 for preventing and treating diabetes, including type I diabetes (TID) and type 2 diabetes. In particular, the invention provides compositions comprising a fragment of the extracellular region of NKp46 for preventing the onset and progression of diabetes.
US08420085B2 Anti-IGF-IR antibodies and uses thereof
The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor IGF-IR and/or capable of specifically inhibiting the tyrosine kinase activity of said IGF-IR, especially monoclonal antibodies of marine, chimeric and humanized origin, as well as the amino acid and nucleic acid sequences coding for these antibodies. The invention likewise comprises the use of these antibodies as a medicament for the prophylactic and/or therapeutic treatment of cancers overexpressing IGF-IR or any pathology connected with the overexpression of said receptor as well as in processes or kits for diagnosis of illnesses connected with the overexpression of the IGF-IR. The invention finally comprises products and/or compositions comprising such antibodies in combination with anti-EGFR antibodies and/or anti-VEGF antibodies and/or antibodies directed against other growth factors involved in tumor progression or metastasis and/or compounds and/or anti-cancer agents or agents conjugated with toxins and their use for the prevention and/or the treatment of certain cancers.
US08420074B2 Methods of making and using Lactobacillus strains
Lactobacillus strains that have a genetic Profile I based on Apa I, Not I, and Xba I digests are provided. Preferably, the strains decrease level of at least one of coliforms and E. coli within the gastrointestinal tract of an animal. A direct-fed microbial that includes the strain is additionally provided. A method of feeding an animal the strain and a method of forming a direct fed microbial that includes the strain is also provided.
US08420071B2 Herpes simplex virus expressing foreign genes and method for treating cancers therewith
An anti-cancer pharmaceutical composition includes a herpes simplex virus (HSV) vector into which a nucleic acid sequence encoding for an anti-cancer agent selected from interleukin-12, GM-CSF, and CD has been inserted. A method of treatment of a patient suffering from cancer includes administering to the patient the anti-tumor pharmaceutical composition including a HSV vector having a nucleic acid sequence encoding for an anti-cancer agent selected from interleukin-12, GM-CSF, and CD inserted therein.
US08420066B2 O/W emulsion cosmetic composition
Provided is an O/W emulsion cosmetic composition, which contains the following components (A), (B) and (C): (A) a polymer which is either a nonionic or cationic polymer composed of a hydrophobic monomer unit and a hydrophilic monomer unit and contains from 40 to 80 wt. % of a hydrophilic group; (B) a dispersion containing the following components (a), (b), (c) and (d): (a) powders having ultraviolet screening ability and having a surface subjected to hydrophobic treatment, (b) a polymer composed of a hydrophobic monomer unit and a hydrophilic monomer unit, (c) a silicone oil, and (d) an alcohol having from 1 to 3 carbon atoms, at an (a):(b):(c):(d) weight ratio of (from 25 to 65):(from 0.1 to 5):(from 10 to 50):(from 10 to 50); and (C) water.
US08420065B2 Hair or skin conditioning compositions comprising hydrophobically modified amido silicone copolyol
Disclosed are hair or skin conditioning compositions comprising by weight: (a) from about 0.1% to about 10% of a thickening polymer system; (b) from about 0.1% to about 8.0% of a surfactant system selected from the group consisting of cationic surfactant, nonionic surfactant, and mixtures thereof; (c) from about 0.1% to about 10% of a hydrophobically modified amido silicone copolyol; and (d) an aqueous carrier; wherein the composition has a transmittance of 25% or more and/or wherein the composition has a viscosity of from about 1,000 cps to about 50,000 cps and Shear Thinning Index of 30 or more. The compositions are especially suitable for hair care products such as hair conditioning products for rinse-off/leave-on use.
US08420063B2 Lip cosmetics
The present invention provides a lip cosmetic that has good gloss and good stability, while maintaining post-application secondary adhesion resistance. The lip cosmetic of the present invention is characterized by comprising the following components (a) to (d): (a) 4.5 to 35 mass % of glyceryl monoisostearate; (b) 20 to 80 mass % of one or more kinds of methyl phenyl silicones that do not separate out when mixed with (a) at 90° C. and separate out when mixed with (a) at 25° C.; (c) 5 mass % or more of water and/or glycerin, relative to the component (a), and 24 mass % or less, relative to the total amount of the cosmetic; and (d) 4 to 10 mass % of a wax.
US08420059B2 Aerosol composition
A single phase aerosol composition comprising the following constituents: (a) 5 to 75 wt % of a hydrofluorocarbon(s) (HFC) of vapor pressure greater than or equal to 4 bar at 20° C. (60 psig at 70° F.); (b) 10 to 30 wt % of a hydrocarbon propellant; (c) 1 to 70 wt % of a hydrocarbon solvent(s) with a vapor pressure of less than 0.1 mm Hg at 20° C.; (d) 0.01 to 10 wt % of an active constituent(s) selected from the group which includes fragrances, air-sanitisers, air fresheners, deodorizers, odor eliminators, malodor counteractants, insecticides, insect repellants, medicinal substances, disinfectants, aroma therapy compositions; and, (e) 0 to 25 wt % of an adjuvant constituent(s) other than (a), (b), (c) or (d). Methods of making the said composition and aerosol dispensers containing the said composition are also disclosed.
US08420051B2 Muteins of hNGAL and related proteins with affinity for a given target
The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also relates to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates a method for producing such a mutein. Furthermore, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.
US08420050B2 Gastrin releasing peptide compounds
Novel methods of treating prostate tumors or of delaying the progression of prostate tumors are also provided, including, methods of treating bone or soft tissue metastases of prostate cancer methods for treating hormone sensitive and hormone refractory prostate cancer, methods for delaying the progression of hormone sensitive prostate cancer, for facilitating combination therapy in patients with hormone sensitive prostate cancer and for decreasing aberrant vascular permeability in patients with hormone sensitive prostate cancer, said methods comprising the step of administering to a subject a dose comprising an amount of radioactively labeled L70, N-[4-[[[[[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]acetyl]amino]benzoyl]-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-leucyl-L-methioninamide.
US08420048B1 System and method for parallel solution extraction of one or more metal values from metal-bearing materials
The present disclosure relates to a process and system for recovery of one or more metal values using solution extraction techniques and to a system for metal value recovery. In an exemplary embodiment, the solution extraction system comprises a first solution extraction circuit and a second solution extraction circuit. A first metal-bearing solution is provided to the first and second circuit, and a second metal-bearing solution is provided to the first circuit. The first circuit produces a first rich electrolyte solution, which can be forwarded to primary metal value recovery, and a low-grade raffinate, which is forwarded to secondary metal value recovery. The second circuit produces a second rich electrolyte solution, which is also forwarded to primary metal value recovery. The first and second solution extraction circuits have independent organic phases and each circuit can operate independently of the other circuit.
US08420045B2 Use of redox mass having a spinel type structure for a looping redox process
The invention relates to the use of a novel type of active mass in looping redox processes. Said mass contains a spinel of formula Cu1−xFe1+xAlO4 with 0≦x≦0.1. The active mass according to the invention has a high oxygen transfer capacity and improved oxidation and reduction rates.
US08420041B2 High-pressure vessel for growing group III nitride crystals and method of growing group III nitride crystals using high-pressure vessel and group III nitride crystal
The present invention discloses a high-pressure vessel of large size formed with a limited size of e.g. Ni—Cr based precipitation hardenable superalloy. Vessel may have multiple zones. For instance, the high-pressure vessel may be divided into at least three regions with flow-restricting devices and the crystallization region is set higher temperature than other regions. This structure helps to reliably seal both ends of the high-pressure vessel, at the same time, may help to greatly reduce unfavorable precipitation of group III nitride at the bottom of the vessel. Invention also discloses novel procedures to grow crystals with improved purity, transparency and structural quality. Alkali metal-containing mineralizers are charged with minimum exposure to oxygen and moisture until the high-pressure vessel is filled with ammonia. Several methods to reduce oxygen contamination during the process steps are presented. Back etching of seed crystals and a new temperature ramping scheme to improve structural quality are disclosed.
US08420036B1 Control of NO/NO2 ratio to improve SCR efficiency for treating engine exhaust using bypass oxidation catalyst
Methods and systems for treating NOx-containing exhaust from an internal combustion engine. An exhaust aftertreatment system has at least a primary oxidation catalyst, a particulate filter, and a selective reduction catalyst (SCR). A bypass line diverts a portion of the exhaust from the exhaust line from a point downstream the particulate filter to a point upstream the SCR. A secondary oxidation catalyst on the bypass line is used to generate NO or NO2 to be returned to the exhaust line upstream the SCR.
US08420033B2 Compositions and methods to sequester flue gas mercury in concrete
Mercury adsorbed from combustion gas by activated carbon can be sequestered in concrete containing air entraining admixtures. The activated carbon may be made by providing a carbon char made from anthracite or low-volatile bituminous coal that was devolatilized and carbonized in an oxygen-depleted environment and activating this char in the presence of steam to provide an activated carbon with an acid blue 80 index of less than about 30 milligrams per gram of carbon. The activated carbon may also be made by providing a carbon char that was devolatilized and carbonized in an oxygen-depleted environment and activating this char in the presence of oxygen to provide an activated carbon. The carbon may be injected into a combustion gas stream containing fly ash and mercury and may then be removed with fly ash from the gas stream. The resulting composition may be used as a partial substitute for cement in air-entrained concretes.
US08420030B2 Well plate for holding a sample during analysis and a method for preparing a sample for analysis
A well plate (1) for holding samples of a bodily fluid during analysis thereof, typically in an analytical apparatus, comprises a plate (2) having a plurality of first wells (3) extending downwardly therefrom for holding a sample during optical analysis of the sample, and a plurality of second wells (4) for holding samples during mechanical analysis of the samples. A plurality of holding wells (8) are provided for initially receiving and holding samples of the bodily fluid to be analysed so that samples of relatively accurate size can be pipetted from the holding wells (8) to the first and second wells (3,4).
US08420029B2 Clean transportation system
A transportation system for transporting a biological material container between a sterile field and a nonsterile field and substantially maintaining sterility of the biological material container includes a housing assembly that removably houses the biological material container. The system also includes a port defined by the housing assembly, and the port provides communication into the biological material container from outside the housing assembly. The housing assembly includes a first member that covers a first portion of the biological material container such that a second portion of the biological material container extends from the first member. The housing assembly also includes a second member that covers the second portion of the biological material container. The second member is removably coupled to the first member to expose the second portion of the biological material container. A keying member that keys the transportation system in a centrifuge is also disclosed.
US08420020B2 Honeycomb filter and method for manufacturing honeycomb filter
A honeycomb filter includes a plurality of porous partition portions each forming a cell, which is open at one end and closed at the other end and serves as an exhaust gas flow path, and a trapping layer, for trapping and removing solid components contained in the exhaust gas, formed on each of the partition portions. At least part of each of the partition portions is loaded with a catalyst. The amount of catalyst a (g/L) in an upstream partition portion and the amount of catalyst b (g/L) in a downstream partition portion satisfy 1.05≦a/b≦3.00. A method for limiting a/b to this range includes the entire honeycomb structure, including the partition portions, into contact with a catalyst component to form a catalyst, and subsequently bringing only an upstream region of the honeycomb structure into contact with a catalyst component to form a catalyst.
US08420016B2 Microbial deactivation apparatus having integrated ultrasonic drying system
A system for microbially deactivating articles, such as medical, dental, veterinary and mortuary instruments and devices. The system includes vibration means for producing ultrasonic waves to facilitate drying after the completion of a liquid microbial deactivation process.
US08420012B2 Use of monochlorourea to treat industrial waters
The present invention comprises a method for controlling (e.g. inhibiting) or killing microorganisms in an aqueous environment. The method includes the addition of an effective amount of monochlorourea or modified monochlorourea to an aqueous solution. This aqueous solution may be a cooling water system, a recreational water system, a water treatment facility, or any circulating water system (i.e. a papermaking facility). A method of producing monochlorourea or modified monochlorourea is also disclosed.
US08420011B2 Aluminum alloy plate and process for producing the same
The present invention provides an Al—Mg series alloy sheet of high-Mg with improved press formability and homogeneity which can be applied to automobile outer panels and inner panels. This is an Al—Mg series aluminum alloy sheet having 0.5 to 3 mm in thickness cast by twin-roll continuous casting and cold rolled, comprising over 8% but not more than 14% Mg, 1.0% or less Fe, and 0.5% or less Si with the remainder being Al and unavoidable impurities wherein the mean conductivity of the aluminum alloy sheet is in the range of at least 20 IACS % but less than 26 IACS %, the strength-ductility balance (tensile strength×total elongation) as a material property of the aluminum alloy sheet is 11000 (MPa %) or more, and the homogeneity and press formability of the sheet have been improved.
US08420007B2 Apparatus for direct smelting of zinc bearing compounds to produce metallic zinc
Apparatus for producing lead and zinc from concentrates of zinc and lead sulfides or oxides, including: a source of zinc ore and/or lead ore concentrates, iron bearing and carbon containing materials; metallic iron fines and iron oxide fines; carbonaceous reductant; fluxing agent; and a binder; a mixer for forming a mixture from said concentrates and other materials; an agglomerator communicating with the mixer for forming agglomerates from the mixture; a melting furnace for melting the mixture and vaporizing lead and zinc; a pressure sealed feed system communicating with the agglomerator and the melting furnace for introducing agglomerates to the melting furnace; a pressure sealed chamber surrounding the melting furnace; a water-cooled condenser for receiving the vaporized metal and cooling and condensing the metal vapors to liquid metal; a tapping device communicating with the condenser for removing the liquid metal; and associated devices for separating the zinc and lead and recovering the lead and zinc metal separately.
US08420003B2 Method of manufacturing a belt member and the belt member
A tube material is formed by continuously extruding a thermoplastic resin material in the shape of a cylinder that has a thickness of 100 μm and a circumferential length of 800 mm. After that, in a polishing process, the tube material is rubbed with a lapping tape of #2000 while being rotated in one direction at a fixed speed, so that circumferential stripes are formed on the outer circumferential surface of the tube material. Then, the circumferential stripes are thermally transferred by pressing the outer circumferential surface of the heated tube material against a mold surface that is finished in the shape of circumferential stripes by a thermal transfer process.
US08420002B2 Method of RTM molding
A method of RTM molding wherein a reinforcing fiber substrate is placed in a mold, each of a first and a second resin distribution media exhibiting a resin flow resistance lower than the resistance of the reinforcing fiber substrate is placed on each surface of the reinforcing fiber substrate, and the inside of the mold is evacuated and a resin is injected into the mold to thereby impregnate the reinforcing fiber substrate with the resin injected, characterized in that the first resin distribution medium exhibits a resin flow resistance lower than that of the second resin distribution medium, and the evacuation is carried out through the second resin distribution medium while the resin is injected through the first resin distribution medium. The method can be advantageously employed for producing, in particular, FRP structure which is thick and excellent in designability, lightweight property and/or strength.
US08419997B2 Method and device for injection molding plastic material
The present invention relates to a method and to a device for injection molding plastic material, wherein the starting plastic material to be treated is first subjected to a pretreatment, wherein the plastic material is heated in a receiving container at a temperature below the melting temperature while constantly being mixed, and thereby at the same time is crystallized, dried and/or cleaned and/or the intrinsic viscosity thereof is increased. According to the invention, the plastic material pretreated in this way is transferred into a screw injection molding machine (10) having a screw (16) rotating in a housing (17) and being axially displaceable therein and/or acting as a piston, is plasticized in said screw, and molded into a molded part, for example a preform.
US08419993B2 Extrusion blow molding machine and method for the production of a hollow plastic body
The invention relates to an extrusion blow molding machine (1) with at least one extrusion head (2) and with at least two sheet dies (3), arranged next to one another, for the extrusion of sheet-like plastic preforms (4), with a multipart molding die (5) for processing two preforms into an essentially closed hollow body, having a device for handling the preforms (4). The device for handling the preforms comprises at least two grippers (10), arranged next to one another on a common carrier (8), for receiving the preforms (4), the distance between the grippers (10) being variable.
US08419992B2 Mold for gasket, method for manufacturing the gasket, and gasket
This invention provides a mold for a gasket, which can render the planar shape of a mold for integral molding of a large-diameter gasket as small as possible to reduce the size of the manufacturing equipment and, at the same time, by virtue of integral molding, does not require labor and time in the manufacture thereof and does not cause a lack of strength in the connecting part. To this end, a mold (1) for molding an endless-type gasket comprises a plurality of molding parts (11,21), formed by disposing two molding grooves (12, 22), in a spiral wound form, in parallel so as to be adjacent to each other. The spiral wound molding grooves (12, 22) have reversing parts (14, 24) in their respective inner ends (13, 23), and, at the same time, their outer ends (15, 25) are connected to each other in a rope form.
US08419980B2 Ternary thermoelectric material containing nanoparticles and process for producing the same
A thermoelectric material that comprises a ternary main group matrix material and nano-particles and/or nano-inclusions of a Group 2 or Group 12 metal oxide dispersed therein. A process for making the thermoelectric material that includes reacting a reduced metal precursor with an oxidized metal precursor in the presence of nanoparticles.
US08419977B2 Conductive coating, method for preparing a coating, roller, and method for manufacturing a roller and using a coating
A conductive coating is described, suitable for coating a developer, charge or transfer roller in a developing apparatus to give a charge providing layer. The coating comprises a conductive polymer in a matrix. A roller is also described, suitable for a developing apparatus comprising, from the center to the periphery, a conductive mandrel, a conductive elastic base layer and a charge providing layer.
US08419976B2 Polyelectrolyte complexes as thickeners for high ionic strength salt solutions
A polyelectrolyte complex composition capable of viscosifying or thickening an aqueous high salt-containing system comprises a mixture of at least one anionic polymer and at least one cationic polymer in an inorganic salt-containing aqueous medium. The anionic polymer and cationic polymer can each be linear and water-soluble, crosslinked and water-soluble, or crosslinked and water-insoluble or swellable.
US08419973B2 Polymerizable liquid crystal composition and homeotropically-aligned liquid crystal film
A polymerizable liquid crystal composition is provided that can contains a mixture of polymerizable compounds containing a compound represented by the formula (1-1), a compound represented by the formula (2), a compound represented by the formula (3-1) and a compound represented by the formula (4), and a amine silane coupling agent. The composition can form a polymerizable liquid crystal layer exhibiting a uniform homeotropic alignment by coating the composition on a supporting substrate, independently from the kind of the supporting substrate without a special alignment film. Examples of each of the components are shown below, in which ring T represents triptycen-1,4-diyl.
US08419971B2 Method for producing mechanically stable water-absorbent polymer particles
A process for producing water-absorbing polymer particles by polymerizing droplets of a monomer solution in a gas phase surrounding the droplets, wherein the particle surface is coated at least partly with at least one polymer and/or wax.
US08419970B2 Silicon nitride polishing liquid and polishing method
A silicon nitride polishing liquid for chemical mechanical polishing of a body to be polished in a planarization process for manufacturing of a semiconductor integrated circuit, the body to be polished including at least a first layer containing silicon nitride and a second layer containing at least one silicon-including material selected from the group consisting of polysilicon, modified polysilicon, silicon oxide, silicon carbide, and silicon oxycarbide, the silicon nitride polishing liquid having a pH of 2.5 to 5.0, and including (a) colloidal silica, (b) an organic acid that has at least one sulfonic acid group or phosphonic acid group in the molecular structure thereof and functions as a polishing accelerator for silicon nitride, and (c) water.
US08419968B2 Lubricants for refrigeration systems
A polyol ester suitable for use as a lubricant or a lubricant base stock has a kinematic viscosity at 40° C. less than or equal to 22 cSt and a viscosity index of greater than or equal to 140. The ester comprises a reaction product of (a) at least one polyhydric alcohol having at least 2 primary hydroxyl groups, (b) at least one monocarboxylic acid having 2 to 15 carbon atoms and (c) at least one polycarboxylic acid having 2 to 15 carbon atoms, wherein the number of acid groups derived from the polycarboxylic acid(s) is at least 25% of the total number of acid groups derived from the monocarboxylic and polycarboxylic acids.
US08419961B2 Oil/gas separation membrane, its use in gas sensor and process for producing the same
An oil gas separation membrane combines a gas permeable yet oil and temperature resistant bulk polymer membrane such as poly(tetrafluoroethylene) and poly(tetrafluoroethylene-co-hexafluoropropylene); a porous metal support such as sintered metal frit disk made with stainless steel, bronze or nickel; and an highly gas permeable adhesive that bonds firmly the bulk polymer membrane and the metal frit surface together. The adhesive is either a homogenous polymer that has desirable gas permeability, or a coalescent porous polymer particulates network. A gas sensor employing the oil gas separation membrane for detecting and monitoring fault gases of oil filled electrical equipment requires no mechanical wearing or moving part such as pump and valve and the gas sensor is operated normally under various temperature and pressure conditions.
US08419959B2 Clamped monolithic showerhead electrode
An electrode assembly for a plasma reaction chamber used in semiconductor substrate processing. The assembly includes an upper showerhead electrode which is mechanically attached to a backing plate by a series of spaced apart cam locks. A guard ring surrounds the backing plate and is movable to positions at which openings in the guard ring align with openings in the backing plate so that the cam locks can be rotated with a tool to release locking pins extending from the upper face of the showerhead electrode.
US08419954B1 Method for providing a side shield for a magnetic recording transducer
A method for fabricating a side shield for a magnetic transducer is described. The transducer has a nonmagnetic layer, a pole, a gap layer between the pole sidewalls and the nonmagnetic layer, and a hard mask having a hard mask aperture. A removal mask having a removal aperture exposing part of the pole and hard mask aperture is provided. The removal mask covers part of the hard mask aperture and the part of the hard mask. A trench in the nonmagnetic layer is formed by removing part of the nonmagnetic layer. A seed layer is deposited. A deposition mask having a deposition aperture therein is provided. The deposition aperture exposes part of the trench and part of the nonmagnetic layer. Side shield material(s) are deposited. Part of the side shield material(s) external to the deposition trench are removed. A remaining portion of the side shield material forms the side shield.
US08419952B2 Method of manufacturing magnetic recording medium and magnetic recording apparatus
According to one embodiment, a method of manufacturing a patterned medium includes forming an implantation depth-adjusting layer above a magnetic recording layer, the magnetic recording layer being made of a material that is deactivated when implanted with a chemical species, and the implantation depth-adjusting layer being made of a material that is etched when irradiated with an ion beam of the chemical species and irradiating the implantation depth-adjusting layer with the ion beam to implant the chemical species into a part of the magnetic recording layer through the implantation depth-adjusting layer while etching the implantation depth-adjusting layer by an action of the ion beam to decrease a thickness of the implantation depth-adjusting layer.
US08419951B2 Method of manufacturing magnetic recording medium, and magnetic recording/reproducing device
A method of manufacturing a magnetic recording medium is provided, which include: forming a magnetic layer on the surface of a nonmagnetic substrate; forming a groove in which a nonmagnetic section is formed by etching a portion corresponding to a formation region of the nonmagnetic section in the magnetic layer and a magnetic recording section formed of the magnetic layer; applying a resin having an active energy ray curable functional group to the surface of the magnetic recording section so as to fill the groove; pressing a plate material against the resin so that the smooth surface of the plate material is in contact with the surface of the resin to make the surface of the resin smooth; removing the plate material from the resin; and forming the nonmagnetic section in the groove by etching and removing a portion located above the surface of the magnetic recording section in the resin having a smooth surface.
US08419950B2 Pattern forming method
According to one embodiment, a pattern forming method is disclosed. The method includes contacting a template with light curable resin on a substrate. The template comprises a concave-convex pattern including concave portions and convex portions, and a metal layer provided on a convex portion of the concave-convex pattern. The concave-convex pattern is to be contacted with the light curable resin. The pattern forming method further includes irradiating the light curable resin with light of a predetermined wavelength under a condition ε1=−2ε2. Where ε1 is a complex relative permittivity of the metal layer corresponding to the predetermined wavelength, ε2 is a complex relative permittivity of the light curable resin corresponding to the predetermined wavelength.
US08419940B2 Combined axial piston liquid pump and energy recovery pressure exchanger
A pumping machine, that can serve a system as the sole main pump for pressurizing a primary liquid flow, incorporates, in a single machine, a rotor-drum type AP (axial piston) pump and a PX (pressure exchanger) that recovers energy from a secondary liquid flow such as the brine discharge from an RO seawater desalination system, with benefits including fewer moving parts and small machine size along with lower capital and operating costs. A single rotor-drum containing the cylinders and pistons is located between two end blocks, one or both configured with manifold passageways, ports and sliding valves. A swash-plate at one end reciprocates the pistons axially when the rotor-drum is rotated. Two working chambers, primary and secondary, are formed at opposite ends of a single piston in each cylinder, thus enabling the single rotor-drum to function as a primary liquid-pressurizing axial pump (AP) with sliding valves at the primary end enabling primary liquid pumping, and as a secondary outflow-driven pressure exchanger (PX) recovering energy from pressure drop in the secondary liquid flow and thus contributing work to primary pumping, saving energy and reducing operating costs.
US08419939B2 Micro dialyzer
A spherical dialysis chamber with a heavier cap (the density of cap material is higher than that of the dialyzer) or the distribution of weight is such that it is higher weight distribution is towards the cap, so that it tilts always towards the bottom of the container containing the dialysis buffer.
US08419932B2 Method and apparatus for separating cooking oils from snack food products through a quasi-continuous centrifuge action
A centrifuge operative in successive low speed and high speed modes serves to remove surface cooking oil from a continuous stream of fragile snack food products wherein the oil removal occurs in the high speed mode and products are discharged from the centrifuge with relatively low kinetic energy in the low speed mode.
US08419930B2 System for preparing high-quality gasoline through component oil refining hydrocarbon recombination hydrogenation and method thereof
The invention discloses a system for preparing high-quality gasoline through component oil refining hydrocarbon recombination hydrogenation and a method thereof, which is characterized by comprising an extraction system, a distillation system and a hydrogenation device, wherein the upper part of the extraction system is connected with the distillation system through a pipeline, and the lower part of the extraction system is connected with an extract oil hydrogenation device through the pipeline; light gasoline is recovered by the upper part of the distillation system through the pipeline; the lower part of the distillation system is connected with the heavy gasoline hydrogenation device through the pipeline; and reformate or ethylene feed are recovered through the lower part of the heavy gasoline hydrogenation device through the pipeline. The system for preparing high-quality gasoline through component oil refining hydrocarbon recombination hydrogenation and the method thereof has small scale and low cost and can remove olefin, mercaptan sulphur and diene.
US08419926B2 Electrolyzed water producing method and apparatus
Electrolyzed water producing method and apparatus are provided which are capable of producing electrolyzed water having a desired property irrespective of the quality of raw water supplied and the like while allowing the size and weight of the apparatus and the cost to be reduced by limiting the capacity of an electrolysis power source. The electrolyzed water producing method includes: circulating an aqueous electrolyte solution to a first electrolytic chamber of a pair of electrolytic chambers opposed to each other across an intervening ion permeable diaphragm while supplying raw water to the second electrolytic chamber; and applying a predetermined voltage to a pair of electrodes disposed in the respective electrolytic chambers with the diaphragm intervening there between, to electrolyze the raw water and the aqueous electrolyte solution, thereby producing electrolyzed water in the second electrolytic chamber.
US08419923B2 Lithographic printing plate support
A method for making a lithographic printing plate support is disclosed comprising the steps of: (i) providing an aluminum support; (ii) treating said support in an aqueous solution; (iii) graining said treated support in an electrolyte solution by applying an alternating voltage thereby inducing a local current density J; characterized in that said local current density J at time t fulfills the following equation: J(t)≦a+bQ(t) for t=o to t=tf and wherein Q(t) is the integrated value of the absolute value of the local current density at time t:(I)—a is equal to 5—b is equal to 10—and tf is the time necessary to obtain a value of Q(t) equal to 50 C/dm2. Q ⁡ ( t ) = ∫ 0 t ⁢  J ⁡ ( τ )  ⁢ ⅆ τ
US08419922B2 Efficient production of hydrogen
A liquid phase process for producing hydrogen gas in a reactor comprising the step of combining at least one oxidizable reactant with liquid water and at least one alkaline electrolyte to form a mixture having a pH, wherein the pH of the mixture is substantially maintained at a value of about 10.5 or greater and conducting a reaction in the presence of an electron transfer material that permits the movement of electrons. An alternative method produces hydrogen gas from a reaction in an electrochemical cell, the reaction characterized by an overall thermodynamic energy balance and half-cell reactions occurring at each of an anode and cathode. Energy transfers, such as thermal and electric, are analyzed and controlled in order to satisfy the thermodynamic energy balance of the reaction for efficient hydrogen production.
US08419921B2 Electrolytic apparatus for producing fluorine or nitrogen trifluoride
It is a task of the present invention to provide an electrolytic apparatus for producing fluorine or nitrogen trifluoride by electrolyzing a hydrogen fluoride-containing molten salt, the electrolytic apparatus being advantageous in that the electrolysis can be performed without the occurrence of the anode effect even at a high current density and without the occurrence of an anodic dissolution. In the present invention, this task has been accomplished by an electrolytic apparatus for producing fluorine or nitrogen trifluoride by electrolyzing a hydrogen fluoride-containing molten salt at an applied current density of from 1 to 1,000 A/dm2, the electrolytic apparatus using a conductive diamond-coated electrode as an anode.
US08419920B2 Method of preparing electrolytic copper solution acidified with sulfuric acid, sulfuric-acid-acidified electrolytic copper solution prepared by the preparation method, and electrodeposited copper film
An object of the present invention is to provide a method for preparing a sulfuric acid base copper electrolytic solution used for formation of an electro-deposited copper film comprising a surface excellent in smoothness and gloss when formed by using the solution just after preparation and is prepared by using mono-sulfides. To achieve the object, a sulfuric acid base copper electrolytic solution is made to contain a sulfonated active sulfur compound, the bis(3-sulfopropyl)disulfide which is recommended for formation of a glossy electro-deposited copper film. And the bis(3-sulfopropyl)disulfide contained is obtained by converting a 3-mercapto-1-propanesulfonic acid into the bis(3-sulfopropyl)disulfide in an aqueous solution of the 3-mercapto-1-propanesulfonic acid by an oxidation reaction. In the oxidation reaction, an air bubbling method is preferably used to prevent oxidative decomposition of the 3-mercapto-1-propanesulfonic acid.
US08419919B1 System and method for generating particles
A method may include the steps of supplying current to the electrodes of an electrochemical cell according to a first charging profile, wherein the electrochemical cell has an anode, cathode, and electrolytic solution; maintaining a generally constant current between the electrodes; exposing the cell to an external field either during or after the termination of the deposition of deuterium absorbing metal on the cathode; and supplying current to the electrodes according to a second charging profile during the exposure of the cell to the external field. The electrolytic solution may include a metallic salt including palladium, and a supporting electrolyte, each dissolved in heavy water. The cathode may comprise a second metal that does not substantially absorb deuterium, such as gold. The external field may be a magnetic field.
US08419917B2 Electroplating head and method for operating the same
An electroplating head is disposed above and proximate to an upper surface of a wafer. Cations are transferred from an anode to an electroplating solution within the electroplating head. The electroplating solution flows downward through a porous electrically resistive material at an exit of the electroplating head to be disposed on the upper surface of the wafer. An electric current is established between the anode and the upper surface of the wafer through the electroplating solution. The electric current is uniformly distributed by the porous electrically resistive material present between the anode and the upper surface of the wafer. The electric current causes the cations to be attracted to the upper surface of the wafer.
US08419913B2 Porous electroconductive material and process for production thereof; electrode and process for production thereof; fuel cell and process for production thereof; and electronic instrument, mobile machine, electric power generating system, cogeneration system, and electrode reaction-based apparatus
A porous electroconductive material is provided. The electroconductive material enables efficient enzymatic metabolic reactions on electrodes and yields electrodes having immobilized enzymes thereon which remain stable in any working environment. The porous electroconductive material, which has a three-dimensional network structure, is formed from a skeleton of porous material and a carbonaceous material covering the surface of the skeleton. The porous material constituting the skeleton is foamed metal or alloy. This porous electroconductive material is made into an electrode, and enzymes are immobilized on this electrode. The resulting electrode with immobilized enzymes thereon is used as the anode of a bio-fuel cell.
US08419904B2 Systems and methods for solar water purification
Systems and methods for solar water purification are described. In one exemplary aspect, the system includes a sun-tracking reflecting mirror unit, and a two-axis Fresnel concentrator mirror unit to collect sunlight reflected from the sun-tracking reflecting mirror unit and focus the sunlight. A central water purification boiler module includes a heating zone upon which the sunlight is focused by the two-axis Fresnel concentrator mirror unit. The focused sunlight heats the water contained therein to create steam which is redirected to heat water coming into the boiler and to condense as purified water.
US08419900B2 Apparatus for pretreatment for saccharification of lignocellulose biomass
To provide an apparatus for pretreatment for saccharification easily and continuously applying a treatment and capable of reusing ammonia at low cost. The apparatus has a mixing unit 2, a first heating unit 3, a separation unit 4, a transfer unit 6, an ammonia water supply unit 8 and an ammonia recovery unit 19. The apparatus may have the first heat exchanger 18, a second heat exchanger 25 and a heat supply unit 27 and further has a second heating unit 14. The apparatus may have a wet grinding unit 32 between the heating unit 3 and 25.
US08419899B2 Paperboard containing recycled fibers and method of making the same
A paperboard comprises from greater than 0% to 100% recycled fibers and has a microorganism count of less than 5,000 colony forming units per gram of paperboard.
US08419896B2 Semi-automated reworkability process for de-bonding a display
A method for reworking a bonded display (e.g., a bonded LCD) having a substrate (e.g., plate or film) adhesively bonded to a face (e.g., front face) of the display. The method provides for efficient and clean removal of the substrate from the bonded display when necessary (e.g., when defect(s) are present) to afford a de-bonded display that is undamaged such that the resulting de-bonded display (e.g., de-bonded LCD) can subsequently be re-bonded as a component in a device being manufactured.
US08419893B2 Shielded lid heater assembly
A shielded lid heater lid heater suitable for use with a plasma processing chamber, a plasma processing chamber having a shielded lid heater and a method for plasma processing are provided. The method and apparatus enhances positional control of plasma location within a plasma processing chamber, and may be utilized in etch, deposition, implant, and thermal processing systems, among other applications where the control of plasma location is desirable. In one embodiment, a shielded lid heater is provided that includes an aluminum base and RF shield sandwiching a heater element.
US08419892B2 Plasma process detecting sensor
The present invention provides a plasma process detecting sensor. In the plasma process detecting sensor, a hole diameter of an insulating film is spread with almost no spread of a hole diameter of an upper electrode. Therefore, when the plasma process detecting sensor is exposed to a plasma, positive ions incident onto the bottom of a contact hole are hard to collide with an inner wall surface of a hole main body of the insulating film. As a result, the inner wall surface of the hole main body of the insulating film is hard to undergo damage, and the generation of a defect level that assists electric conduction can be suppressed. It is thus possible to suppress age deterioration of a sensor function during the measurement of a charge-up under an environment of a plasma etching condition.
US08419890B2 Composition for structural adhesive
The invention relates to composition for an acrylic structural adhesive containing a mixture of block copolymers containing styrene and an elastomer.
US08419889B2 Ultrasecure card package
A package for securing a card is disclosed where the card is retained between two panels that are secured together by a heat-activated adhesives and/or a combination of polymeric and adhesive constituents to drastically hinder surreptitious access to the contents of the package. The package may include additional features for activating or accessing the card and increasing the aesthetic appeal of the package.
US08419887B2 Composite structural member and method for producing the same
A composite structural member is provided. The structural member includes a tubular shaft having a mating region of stiffness, and possibly thickness, greater than another region of said shaft. The shaft defines a lumen, and a fitting is disposed in the lumen. The fitting has a coupling region that defines at least one recessed portion bounded by one or more non-recessed portions, and the mating region mates with the coupling region of said fitting. As such, the shaft and fitting are mechanically restrained from at least some relative movement due to interference of the shaft and the fitting. A sleeve may be coupled to said shaft, for example, by including a tubular inner surface that proximately surrounds at least part of said shaft and mating region, for discouraging expansion of the mating region of said shaft.
US08419884B2 Method for manufacturing multilayer wiring substrate
A method for manufacturing a multilayer wiring substrate processes a via hole without unnecessarily increasing the diameter thereof and which can easily achieve the formation of fine wiring. A first resin layer in a cured state is prepared in which at least one first via hole including a bottom made of a conductive pattern is formed by laser processing, a second resin layer in an uncured state is prepared in which at least one second via hole is formed to penetrate therethrough at a position corresponding to the first via hole, and the first resin layer and the second resin layer are laminated to each other so that the first via hole and the second via hole communicate with each other. After a conductive paste is simultaneously filled in the first via hole and the second via hole, a metal foil is pressure-bonded to the second resin layer, and the second resin layer and the conductive paste are simultaneously cured. Subsequently, the metal foil is patterned.
US08419880B2 Method of transferring graphene
A method of transferring graphene, the method including: preparing a graphene forming structure including a base member, an oxide layer that is hydrophilic and is formed on the base member, a metal catalyst layer that is hydrophobic and is formed on the oxide layer, and graphene that is formed on the metal catalyst layer; attaching the graphene forming structure on a surface of a first carrier; separating the oxide layer from the metal catalyst layer by applying steam to the graphene forming structure; and removing the metal catalyst layer.
US08419874B2 Method for making diaper
A method of making a diaper includes: forming the continuous sheet at a distance in a width direction from an imaginary center line M bisecting the width dimension of the continuous sheet with let-through openings for passage of feces at a regular pitch, bonding absorbent panels, each having an absorbent core to the middle section of a sheet piece having an area larger than the area of the absorbent core; coating the surface of the continuous sheet opposite to the surface to which the absorbent panels have been bonded with hot melt adhesive HM; and cutting the assembly of the continuous sheet and the absorbent panels along the imaginary vertical line V defined between each pair of the adjacent absorbent panels at the regular pitch to obtain the diapers.
US08419872B2 Asphalt-based reactive polyurethane roof membrane adhesive
A cold applied adhesive that includes a blend of polyurethane pre-polymer, petroleum liquid and additive. The weight percent of petroleum liquid in the blend is less than 50 weight percent. The weight percent of polyurethane pre-polymer in the blend is less than 50 weight percent.
US08419870B2 Method for making strain aging resistant steel
A method for making a strain aging resistant steel comprises adding boron to the steel, wherein substantially all of the boron in the steel forms boron nitride. A method for making steel comprises adding a nitride-forming element to the steel to lower the free nitrogen content of the steel to a free nitrogen content specification. A high-carbon steel contains boron nitride, wherein the free nitrogen content of the steel is less than 80 ppm. A strain aging resistant steel wherein the carbon content of the steel is between about 0.54 percent and about 0.75 percent.
US08419867B2 Gold alloy compositions formed by environmentally friendly process
Rose-color and yellow-color gold alloys are formed from a gold-base alloy containing silver and copper. Mining these elements is usually highly detrimental to the environmental. Environmentally friendly alloys are obtained through the use of recycled elements and elements recovered from mines utilizing specific guidelines. Jewelry manufactured from these environmentally friendly alloys may be more receptive to a consumer, resulting in a competitive advantage.
US08419866B2 Method of manufacturing transition metal oxide having spinel structure
A novel method of manufacturing a transition metal oxide having a spinel structure is provided. A mixture of powdery metals of metal elements constituting the transition metal oxide is heated in an oxidizing atmosphere to generate the transition metal oxide.
US08419865B2 Heat recovery system for use with a washing appliance
A heat recovery system for use with a washing appliance having a tub includes a heat exchanger having a first tube and a second tube extending through the first tube such that the first tube and the second tube are substantially concentric. A first end connector is configured to couple to a first end portion of the first tube and a first end portion of the second tube. The first end connector is formed as one-piece and includes a first connection portion configured to couple in flow communication with the first tube, and a second connection portion configured to couple in flow communication with the second tube.
US08419864B2 Dishwasher
A dishwasher includes a wash compartment with a retainer, a water connector supported by the retainer and that connects a supply line from a water supply network to a liquid line system of the dishwasher.
US08419861B2 Method for adapting a rinsing program in a dishwasher machine, and corresponding dishwasher machine
A method for adapting a rinsing program in a dishwasher machine, and a dishwashing machine configured to perform the method, the method enabling the rinsing program run of a dishwasher machine to be adapted in such a way that satisfactory cleaning and drying performances are achieved even when using a combination rinse aid. To this end, the rinsing program run is adapted if there is insufficient salt, if the softening device is switched off, and if the dishwasher machine is on.
US08419860B2 Device and method of sensing temperature of a rotating electromagnetic machine
A system and method of determining the temperature of a rotating electromagnetic machine, such as an electric motor or generator. A temperature calibration parameter is calculated based on the temperature of an object situated close to the motor, such as a motor drive connected to the motor, and a first resistance value of the winding. In exemplary embodiments, the motor drive and first resistance value are determined only after the motor has been idle for some predetermined time period. Once the calibration parameter is calculated, the processor uses it along with subsequent resistance measurements to calculate the temperature of the motor.
US08419859B2 Method of cleaning plasma-treating apparatus, plasma-treating apparatus where the cleaning method is practiced, and memory medium memorizing program executing the cleaning method
A method of cleaning a plasma processing apparatus for processing a target in a process container, which is vacuum-evacuatable, using plasma, includes performing a first cleaning process by supplying a cleaning gas into the process container to generate plasma and maintaining the pressure in the process container at a first pressure, and performing a second cleaning process by supplying a cleaning gas into the process container to generate plasma and maintaining the pressure in the process container at a second pressure that is higher than the first pressure. Accordingly, the plasma processing apparatus can be efficiently and rapidly cleaned without damaging at least one of the group consisting of inner surfaces of the process container and members in the process container.
US08419851B2 Sulfate resistant cement
Mixed cement containing mainly ground granulated blast furnace slag with an alumina ratio of 12 to 17.5 mass % and Portland cement, wherein a ratio of mixture of the ground granulated blast furnace slag is made 10 to 60 mass % and wherein plaster having a specific surface area of 7000 cm2/g or more is mixed in by a ratio of 2 to 4 mass % converted to SO3 mass. By using this mixed cement as a concrete material, it is possible to suppress expansion of the concrete even if in contact with soil containing residual sulfates over a long period.
US08419850B2 Aqueous composition containing a carbonate of zirconium and of an alkaline metal salt, and an ammonium halide, as well as its use thereof
The invention relates to an aqueous composition comprising a carbonate of zirconium and of an alkali metal salt, prepared from a zirconium compound and an alkali metal bicarbonate, and an ammonium halide, and to its use as insolubilizing agent in a coating bath for paper or board.
US08419845B2 Air filter
The present invention provides an air filter including a main body, a pressure fan, a filter mode and a fixing assembly. The main body has a containing room, an entrance hole and an exit hole. The pressure fan is disposed in the containing room. The filter mode includes a first filter layer, a second filter layer and a frame body. The first filter layer is disposed in the entrance hole, and the second filter layer is disposed in the frame body. As such, users can select to use only the first filter layer or both filter layers at one time. Moreover, users only need to let the frame body pivot to a position away from the entrance hole so that users can change the filter layers faster and easier.
US08419840B2 Air-conditioning system
The present invention provides an air-conditioning system that supplies a gas to a space to be air-conditioned and/or discharges a gas from the space to be air-conditioned through a permeable membrane in order to provide an air-conditioning system that can sufficiently block suspended matter in the air such as SPM, and can sufficiently introduce outside air in which the permeable membrane is an asymmetric membrane formed of a polymeric material prepared by polymerizing a monomer composition containing a predetermined monomer.
US08419834B2 Air cleaner assembly
In at least some embodiments, the present invention relates to an air cleaner having a housing portion, and a low profile rain cover having an opening on an underside of the cover to allow unfiltered air to enter into the air cleaner. Also, in at least some embodiments, the present invention relates to an air cleaner including a housing and an additional component by which the air cleaner is capable of being directly coupled to a carburetor inlet. In some such embodiments, one or more protrusions can be provided within a channel formed by the housing/additional component to influence air flow. Further, in at least some embodiments, the present invention relates to an air cleaner having a shaped wall formed on a housing portion, where the shaped wall includes both an interior surface and an exterior surface by which air flowing within the air cleaner is imparted with helical motion.
US08419833B2 Apparatus and method for gas-liquid separation
A two phase gas-liquid separation apparatus is provided that shapes the flow in a flow shaping line. Shaping the two-phase flow allows centrifugal force to send the heavier, denser liquid to the outside wall of the flow shaping line and allows the lighter, less dense vapor or gas to occupy the inner wall of the flow shaping line. With the gas positioned on the inner wall of the flow shaping line, an exit port on the inner wall will allow for the majority, if not all, of the gas, along with a low amount of liquid, to be sent to a conventional separator. A high ratio of vapor/liquid at a flow rate much lower than the total flow rate within the flow shaping line is sent to the conventional separator. This allows for efficient separation of the vapor from the liquid with the use of a smaller conventional separator.
US08419826B2 Process for regeneration of adsorbent beds
The invention provides a process for the regeneration of at least one adsorbent bed, comprising at least the steps of: (a) contacting a first adsorbent bed (B1) with a gaseous stream (10) such that at least a portion of adsorbed species in said first adsorbent bed (B1) are released; (b) cooling a second adsorbent bed (B2); wherein a bypass (20) is provided around the second adsorbent bed (B2) and the gaseous stream (10), before contact with the first adsorbent bed (B1), is directed to at least one of (i) the second adsorbent bed (B2), and (ii) the bypass (20) around the second adsorbent bed (B2), wherein the proportion of gaseous stream (10) flowing through the bypass (20) is controlled.
US08419824B2 Method for producing briquette, method for producing reduced metal, and method for separating zinc or lead
An object of the present invention is to produce briquettes that have high strength even when the amounts of binder and water used are decreased as much as possible. A method for producing briquettes that achieve this object includes a step of forming primary granules by using a powder containing a metal oxide and at least one of zinc oxide, lead oxide, and titanium oxide and a step of compressing the primary granules still containing the at least one of zinc oxide, lead oxide, and titanium oxide so as to mold the primary granules into secondary granules.
US08419821B2 Method for treating spheroidal graphite iron and pouring device thereof
A method for treating spheroidal graphite iron includes the step: pouring molten spheroidal graphite iron into a pouring electrical furnace (1); covering the molten spheroidal graphite iron (5) with alkali slag (6) which is melted at high temperature and rich in alkali earth metal ion, rare earth metal ion, or mixture of them; connecting the molten spheroidal graphite iron (5) with the negative pole of the direct current source by one pole (7); connecting the alkali slag (6) with the positive pole of the direct current source by another pole (4), treating the molten spheroidal graphite iron (5) with the alkali slag (6) which is used as electrolyte. The method can prevent the spheroidized fading velocity of the spheroidal graphite iron. The pouring electrical furnace can be used for treating the molten spheroidal graphite iron.
US08419817B2 Self-supporting pleated filter media
The present invention is a filter that includes a length of filter media and a continuous, substantially nonlinear adhesive strand. The filter media has a front face and a rear face. The filter media has a plurality of pleats defined by a plurality of fold lines, each fold line being intermediate oppositely sloping first and second wall surfaces. The plurality of fold lines comprise a first plurality of pleat tips and a second plurality of pleat valleys. The adhesive strand is provided on the front face of the filter media in discontinuous contact with the filter media. The adhesive strand contacts the filter media at a pleat tip and contacts the filter media at a portion of a first wall surface and contacts the filter media at a portion of a second wall surface.
US08419816B2 Gas isolation valve
Provided is a gas isolation valve which separates reactive materials, principally gases, contained in a high temperature reactor from the surrounding atmosphere. The valve is of modular construction with each module having a gas providing section and a gas removal section. Any number of modules can be provided in series. A central chamber, open at each end gives unimpeded access to the high temperature reactor. It is through the central chamber that the product of the reactor is removed and harvested. In the case of Ilas invention the product is carbon nanotubes.
US08419815B1 Bird deflector and air replacement system
A bird deflector and air replacement system for a jet engine, the bird deflector being conical or arcuate in shape as formed by suitable longitudinal and lateral interconnected bars, and the air replacement apparatus being one of a frustum or a selectively perforated tube or a modified cowl with cooperating external spaced-apart channels or openings formed therearound for directing additional air into the mainstream of the jet engine inlet. The system may be manufactured as an aftermarket add-on, or it may be manufactured as original cowl equipment for respective jet engine models.
US08419814B2 Polycrystalline abrasive compacts
A method of manufacturing polycrystalline abrasive elements consisting of micron, sub-micron or nano-sized ultrahard abrasives dispersed in micron, sub-micron or nano-sized matrix materials. A plurality of ultrahard abrasive particles having vitreophilic surfaces are coated with a matrix precursor material in a refined colloidal process and then treated to render them suitable for sintering. The matrix precursor material can be converted to an oxide, nitride, carbide, oxynitride, oxycarbide, or carbonitride, or an elemental form thereof. The coated ultrahard abrasive particles are consolidated and sintered at a pressure and temperature at which they are crystallographically or thermodynamically stable.
US08419813B2 Integrated energy and/or synthesis gas production method by in-situ oxygen production, chemical looping combustion and gasification
The invention relates to an integrated method of in-situ oxygen production, chemical looping combustion and gasification of liquid, solid or gaseous fuels allowing combustion of coal, petroleum coke and/or liquid hydrocarbons and notably heavy and/or extra heavy or bituminous residues for production of synthesis gas under pressure and/or energy.
US08419811B2 Fuel composition
A fuel composition contains at least 74% by volume of C4 to C14 isoalkanes and, pursuant to the determination of the distillation characteristics according to DIN EN ISO 3405, at least 25% by volume of the fuel composition evaporate at temperatures above 110° C. The fuel composition can also contain oxygen-containing organic compounds, aromatic compounds, olefins, and naphthenes.
US08419809B2 Method of manufacturing solid electrolytic capacitor
A solid electrolytic capacitor having an even conductive polymer layer and a method of manufacturing the same are provided. The method of manufacturing a solid electrolytic capacitor includes the steps of forming a conductive polymer layer on an anode element by bringing a dispersion containing a conductive solid and a first solvent into contact with the anode element having a dielectric film formed thereon, washing the anode element with a second solvent higher in boiling point than the first solvent, in which the conductive solid can be dispersed, after the conductive polymer layer is formed, and drying the anode element washed with the second solvent at a temperature not lower than the boiling point of the first solvent and lower than the boiling point of the second solvent.
US08419807B2 Composition including a glyceride and an organophosphonic acid or one of the salts thereof, dyeing or colour-lightening method implementing same and devices
The present invention relates to a composition for coloring or lightening human keratin fibers, comprising, in a cosmetically medium: (a) at least 25 wt. % of one or more fatty substances; (b) one or more salified or unsalified organophosphonic acids; (c) one or more alkalizing agents and/or one or more dyes selected from oxidation dyes, direct dyes and mixtures thereof and (d) one or more oxidizing agents. It further relates to a method of coloring or lightening employing it. Another object of the invention is constituted by kits with two or three compartments for obtaining, after mixing the compositions from the compartments, just before its application, a composition according to the invention.
US08419801B2 Adjustable, remote-controllable orthopaedic prosthesis and associated method
An implantable, adjustable prosthesis includes a first component which may be moved relative to a second component by use of a transcutaneous control signal. A method of operating such a prosthesis is also disclosed.
US08419800B2 Prosthesis
A preassembled acetabular cup prosthesis comprising an outer shell and a ceramic liner located within the shell, said preassembled unit having been assembled ex-vivo under a controlled force selected to optimize the pre-stressing of the components of the prosthesis.
US08419799B2 Assembly tool for modular implants and associated method
An assembly tool (1) for assembly of a first component (2) of a prosthesis (4) to a second component (6) of the prosthesis (4) for use in joint arthroplasty is provided. The tool (1) includes a first member (8) operably associated with the first component (2). The first member (8) defines a first member longitudinal axis (10) of the first member (8). The tool also includes a second member (12) operably associated with the second component (6). The second member (12) defines a second member longitudinal axis (14) of the second member (12). The second member (12) is adapted to provide relative motion of the second member (12) with respect to the first member (8) when the second member (12) is rotated relative to the first member (8) about the second member longitudinal axis (14).
US08419793B2 Coating with antimicrobial agents
A coating with antimicrobial agents for use with medical devices. In one approach, a related method involves coating high temperature vulcanized silicone material with a room temperature vulcanized dispersion.
US08419788B2 Secured strand end devices
A woven, self-expanding stent device has one or more strands and is configured for insertion into an anatomical structure. The device includes a coupling structure secured to two different strand end portions that are substantially aligned with each other. The two different strand end portions include nickel and titanium. The coupling structure is not a strand of the device.
US08419787B2 Implantable intraluminal device and method of using same in treating aneurysms
A method and apparatus for reducing blood flow to an aneurysm proximate to a bifurcation having a source blood vessel a first branch vessel and a second branch vessel, the method comprising: providing a first mesh-like tube of bio-compatible material, the first mesh-like tube exhibiting a porosity index pre-selected to skew blood flow about the bifurcation away from the aneurysm; inserting the first mesh-like tube into the source blood vessel and the first branch vessel; and securing the first mesh-like tube to at least one of the source blood vessel and the first branch vessel, whereby blood flowing from the source blood vessel flows without undue impedance to the first branch vessel and the second branch vessel while being skewed away from the aneurysm.
US08419786B2 Self-expanding stent
The stent of this invention is a self-expanding stent created by a scaffolding lattice. The stent may be made from a nickel-titanium alloy. The lattice is formed from two different types of helices that proceed circumferentially in opposite directions along the longitudinal axis of the stent. The helices have no free ends. The first type of helix is formed by a series of undulations and the second type of helix is formed from a series of connection elements. The undulations may be in a zigzag or sinusoidal pattern. The connection elements connect the junction points lying on adjacent turns of the first type of helix. The junction points are formed by the ascending and descending arms of the undulations or zigzags. The ends of the stent may be formed by a closed circumferential element which is linked by connection elements to a transition zone. The transition zone is formed by a closed loop that connects directly to the first helix. The amplitude of the undulations or zigzags forming the transition zone increases from the closed loop to the point connecting the transition zone with the first type of helix. The closed circumferential element may be made from a radiopaque material. The scaffolding lattice design of the stent provides a stent having a high degree of flexibility as well as radial strength.
US08419780B2 Apparatus for securing an implantable object to bone
A fixation augmentation device (FAD) comprising a generally tubular body having a first end and a second end, said body having an opening adapted to receive a screw therein; a collar attached to the first end of said body, said collar having a non-circular shape and having an opening which is aligned with the opening in said body; and at least one flange disposed at the second end of said body, wherein said at least one flange is extendable from said body in response to a screw being inserted into the hole of said body.
US08419778B2 Uniplanar bone anchor system
The present teachings provide one or more surgical implements for repairing damaged tissue, such as in the case of a spinal fixation procedure. A uniplanar bone anchor system for a fixation procedure is provided. The system can include a bone fastener including a head with a bearing surface and a shaft adapted to engage an anatomy. The system can also include a saddle, which can include a first bore formed about a longitudinal axis that receives the bone fastener and a coupling bore defined transverse to the longitudinal axis. The system can also include a coupling system, which can have a second bearing surface. The coupling system can be received through the coupling bore such that the second bearing surface of the coupling system can contact the bearing surface to permit the bone fastener to move in only one plane.
US08419776B2 Radius-plate assembly
An assembly for reducing a fracture between an epiphysis and a diaphysis of a bone has a bone plate having a fan-shaped outer end formed with a plurality of outer holes and a bar-shaped inner end extending along a longitudinal axis from the outer end and formed with a plurality of inner holes. The plate further is formed on the bar-shaped inner end with a longitudinally extending throughgoing guide slot and between the guide slot and the outer holes with an aperture. A slide has a longitudinally extending leg with an inner end formed with a guide formation engaged into and longitudinally slidable along the guide slot and a crosspiece overlying the aperture and engaging the bone plate to both transverse sides of the aperture. The crosspiece is formed with a transversely elongated slide slot, and a slide screw engaged through the slide.
US08419768B2 Surgical stapling apparatus with powered articulation
The surgical stapling apparatus includes a handle assembly, an elongated body extending distally from the handle assembly, and an articulation mechanism for articulating a tool assembly. The articulation mechanism includes a first gear rotatably mounted on a transmission shaft and configured to engage a second gear, a clutch interconnecting the second gear and a main shaft; and a yoke shaft coupled to the main shaft and adapted to linearly advance a J-channel, the J-channel operatively connected to an articulation link. A motor assembly may rotate the transmission shaft of the articulation mechanism. Alternatively, the articulation mechanism may include an articulation knob. Users may manually rotate the articulation knob to articulate the tool assembly of the surgical stapling apparatus.
US08419767B2 Steerable atrial septal occluder implantation device with flexible neck
An atrial septal occluder device for repairing an atrial septal defect in a human heart includes an elongated catheter for insertion into and moved along a blood vessel and into the heart of a patient. The catheter includes a head portion, a tail portion and a neck portion between the head and tail portions. The neck portion is about 1 cm in length and 2 to 4 mm in diameter. The device also includes an Amplatzer ASO removably fixed to the head of the device and a moveable neck portion for positioning the ASO with respect to the ASD and an activator for closing the ASO over the ASD from outside of the patient's body.
US08419765B2 Medical apparatus
A medical instrument includes a swingable operating section formed of a pair of forceps which rock around a first rocking axis. A tubular sheath includes a distal end portion situated on a proximal end side of the operating section having a circular-section portion having a circular cross-section perpendicular to a longitudinal central axis and a pair of flat portions formed by cutting the opposite sides of the circular-section portion and in sliding contact with the proximal end portions of the forceps. A manipulator advances and retreats in a longitudinal direction of the sheath, thereby rocking the forceps. A junction connects the manipulator for rocking motion around a second rocking axis with respect to the forceps in the flat portions, and is situated on or near a reference plane passing through the longitudinal central axis of the sheath and extending parallel to the second rocking axis when the operating section is closed.
US08419761B2 Blood lancet device
This invention relates to a blood lancet device that is used to collect a small quantity of blood from a human body. More specifically, it relates to a blood lancet device that: can control the depth of the lancet needle's penetration of the skin; can push the lancet to eject; can accurately collect blood by ensuring linear motion; and can reduce the pain involved in blood collection.
US08419760B2 Cutting accessory for a powered surgical handpiece, the cutting accessory including features to facilitate the alignment of the accessory with the handpiece, hold the accessory to the handpiece, facilitate the transfer of torque to the accessory and reduce the wobble of the accessory
A surgical handpiece with a rotating spindle for receiving the coupling head of a surgical attachment or a cutting accessory. A gear train has plural drive heads that simultaneously rotate at different speeds. A clutch assembly has pins that move along the length of the spindle. The clutch assembly sets the position of the pins so they will engage one of the drive heads. The spindle rotates with the drive head with which the clutch pins are engaged.
US08419755B2 Obesity treatment tools and methods
Various obesity treatment tools and methods are described herein, as well as treatments for other gastric-related diseases, e.g., GERD. Treatment includes reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach directly from the interior of the stomach itself. The smaller pouches may be made through the use of individual anchoring devices, rotating probes, or volume reduction devices. A pyloroplasty procedure may also be performed to render the pyloric sphincter incompetent. A gastric bypass procedure may additionally be performed using atraumatic magnetic anastomoses devices so that sugars and fats are passed directly to the bowel while bypassing the stomach. Many of these procedures may be done in a variety of combinations. Treatment may create enforced behavioral modifications by discouraging the ingestion of high-caloric foods.
US08419753B2 Suturing device with split arm and method of suturing tissue
A device for suturing an opening in a tissue, having an elongated shaft, at least two arms movable to a deployed positioning which the arms are non-perpendicular to the shaft, the arms having needle receiving portions; and needles advanceable longitudinally along the shaft toward the needle receiving portions, the needles exiting through side walls of the shaft at a location proximal to the arms.
US08419750B2 Adjustable instruments for use with a localizer
A system for tracking the position of an instrument relative to an area of interest. The system includes an instrument and an instrument guide mounted to the instrument. The instrument guide carries a first localizer proximate the instrument. The first localizer is movable relative to the instrument. The system also includes a fixator configured to be attached to the area of interest. The fixator carries a second localizer proximate the area of interest. The second localizer is movable relative to the area of interest. The first and second localizers are movable in order that the first and second localizers are in communication such that the position of one of the first and second localizers is known relative to the position of the other of the first and second localizers.
US08419743B2 Assembly tool for modular implants and associated method
An assembly tool comprises in an assembled configuration a proximal implant fastener, a distal implant fastener, and a compression member. The assembly tool is operable to hold in the assembled configuration a proximal implant partially engageable with a distal implant during implantation and axial impaction. Axial impaction is exerted through the compression member of the assembly tool. The assembly tool is also operable to securely lock the tapers of proximal and distal implants after impaction by rotating the compression member.
US08419742B2 Instruments and method for preparing an intervertebral space for receiving an artificial disc implant
Instruments and methods for preparing an intervertebral space for receiving an implant. An adjustable trial implant has an adjustable stop mechanism having a stop member connected thereto to vary the distance that a body portion of the trial implant can move into the intervertebral space. Cutting tools for forming cutouts in the adjacent vertebrae use the trial implant and/or a guide to position a cutting tool which may be a burr or a chisel. The chisel cutting tool can be moveable relative to a selected trial implant or the chisel cutting tools can be fixed onto a trial implant shaped body portion.
US08419737B2 Bone grafting material condensing instrument and method of use
In an internal sinus manipulation procedure for augmenting bone of a dental patient between a bony floor of the patient's sinus and a raised portion of the patient's sinus membrane, employing a bone graft material condensing instrument comprising a longitudinally extending handle and a laterally extending distal head having an upper surface bounded by vertically extending substantially flat sides and a flat horizontally extending lower surface and placed within the raised portion of the patient's sinus membrane to condense a previously placed bone graft forming material upon a turning thereof.
US08419736B2 Sternal reconstruction system
A flexible cable for sternal reconstruction, the cable including first and second ends, the first end of the cable including a crimp fitting member, and the crimp fitting member including a flattened disk-like head. Also provided are methods for sternal reconstruction including wrapping a flexible cable having first and second ends around the sternum, tensioning the flexible cable to a desired tension and securing the tensioned cable, wherein the first end of the cable includes a crimp fitting member, and the crimp fitting member includes a flattened disk-like head.
US08419733B2 External fixation apparatus with adjustable pin clamping means
An external fixation device for holding bone fragments in place includes a housing having a number of rotationally adjustable pin holders, each of which is held by a clamping member that simultaneously clamps the pin holder within an internal mounting surface of the housing and a bone pin within the pin holder. A first embodiment includes a number of pin mounting structures, each of which can include a single pin holder. A second embodiment includes one or two pin mounting structures, each of which holds a row of pin holders that is clamped in place by a single clamping member. Other embodiments are formed by fastening together a group of elements to form different housing configurations.
US08419727B2 Impedance mediated power delivery for electrosurgery
An adaptive algorithm monitors the rate of tissue impedance change during an electrosurgical procedure. Impedance levels are examined to determine an impedance ramp and/or slope rate, which indicates the rate at which a target tissue is undergoing a phase or state change. The level of electrosurgical energy applied to the target tissue is adjusted in real time. Energy is applied to the target tissue at levels that allow tissue phase or state change to occur in an optimum fashion. Undesired results such as thermal damage and defective sealing are mitigated. Another embodiment determines impedance achieved within a specific interval and adjusts the electrosurgical energy applied to the tissue after a threshold impedance has been maintained or exceeded for a predetermined interval. A further aspect of the invention provides mitigation during processing for partial tissue coverage of device electrodes or thin tissue.
US08419726B2 Methods and devices for treating tissue
The invention provides a system and method for achieving the cosmetically beneficial effects of shrinking collagen tissue in the dermis or other areas of tissue in an effective, non-invasive manner using an array of electrodes. Systems described herein allow for improved treatment of tissue. Additional variations of the system include array of electrodes configured to minimize the energy required to produce the desired effect.
US08419723B2 Methods for treatment of prostatic tissue
A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe transurethrally. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Another feature of the prostate therapy system is that it can aspirate tissue from the prostate. Yet another feature of the prostate therapy system is that it can rotate during delivery of vapor and aspiration of tissue. Methods associated with use of the prostate therapy system are also covered.
US08419719B2 Target-close electromagnetic energy emitting device
An apparatus having an excitation source that includes at least one laser diode and also having a handpiece with a disposable, bendable tip cannula is disclosed.
US08419718B2 Laser handle and fiber guard
A protective handle for a mobile laser unit wherein the protective handle provides protection to a front section of the mobile laser unit from damage due to bumps and other impacts as the mobile laser unit is transported between treatment locations. The protective handle simultaneously acts to protect an attached optical fiber from damage during transport by limiting a bend radius of the laser fiber. The protective handle includes a U-shaped central segment having rear and forward surfaces defining a fiber optic support structure. The protective handle is attached to the mobile laser unit such that an optical fiber connector is centered within the U-shaped central segment and the optical fiber can rest on the fiber optic support structure.
US08419717B2 Control system configured to compensate for non-ideal actuator-to-joint linkage characteristics in a medical robotic system
A medical robotic system having non-ideal actuator-to-joint linkage characteristics, includes a control system including a proximal control loop with actuator sensor feedback to control dynamic response of an actuator coupled to a distal joint which in turn, is coupled to an end effector to provide a degree of freedom movement of the end effector, a distal control loop with distal joint sensor feedback and feedforward to the actuator to ensure steady-state convergence of the distal joint position, and an end effector control loop with end-point sensor feedback to control the end effector position to reach a commanded end effector position.
US08419715B2 Medical device with an energy supply having at least two energy sources
According to one embodiment, a medical device may include an energy supply. The energy supply may include a lithium-ion polymer battery including at least two battery stacks and a control unit. One of the at least two battery stacks may be a backup energy source. The control unit may monitor and control the energy supply such that when the control unit detects a fault in the at least two battery stacks, the control unit disconnects a faulty battery stack. The energy supply may be rechargeable. Each of the at least two battery stacks may include a positive potential terminal, a negative potential terminal and one or more battery cell.
US08419713B1 Carrier assembly with caps for medical connectors
An assembly for mounting medical connector caps includes a carrier formed from a sheet of material and having an array of holes. The assembly also includes a plurality of medical connector caps. Each cap is inserted into one of the holes of the array. The assembly also includes a plurality of sealing tabs. A distinct sealing tab includes a cover portion that sealingly covers the openable end of a corresponding one of the caps and includes an overhang portion that overhangs the openable end thereof. The overhang portion is dimensioned to include a tether of sufficient length that a tip of the tether overlaps an adjacent portion of the carrier. The tip is affixed to the carrier, so that the corresponding one of the caps is tethered to the carrier by such sealing tab.
US08419709B2 System for detecting and removing a gas bubble from a vascular infusion line
System for detecting and removing gas bubbles from a vascular infusion line, including a cassette adapted for disposition intermediate the fluid line, the cassette including a flexible tube having an inlet port for connection to a supply side of the fluid line, an outlet port configured for connection to a patient side of the fluid line, and a purge port intermediate the inlet and outlet ports, and a base unit adapted to receive the cassette and monitor fluid flow through the tube, the base unit including a sensor to detect the presence of a gas bubble in the fluid flow, a pinch valve adapted to stop the flow of fluid, and a control unit adapted to operate the base unit so that (i) fluid is permitted to flow past the pinch valve when no gas bubble is detected; and (ii) fluid flow is arrested when a gas bubble is detected.
US08419708B2 Transdermal drug administration apparatus having microneedles
It is intended to provide a transdermal drug administration apparatus having microneedles, which is capable of piercing the skin by a simple procedure in the transdermal administration of a biologically active substance (drug) and allows rapid absorption of the biologically active substance. The present apparatus comprises a microneedle device (50) comprising a microneedle substrate (53) having a plurality of microneedles (51) capable of piercing the skin, an absorbent (11) disposed thereon, the absorbent (11) comprising a material capable of absorbing a liquid, and a dissolving solution reservoir (18) disposed on the absorbent (11), the dissolving solution reservoir (18) containing a dissolving solution (16) for dissolving a drug and being capable of disrupting a diaphragm (20) provided the dissolving solution reservoir (18) and the absorbent (11) by pressing. A coating containing a dry drug is disposed on the microneedles (51) and/or the microneedle substrate (53).
US08419704B2 Absorbent article with fastening flaps
An absorbent article (1) includes an absorbent body (5) arranged superpositioned onto a backsheet (4). The absorbent article (1) has a side edge (6; 12a, 12b) encompassing the absorbent article (1). The absorbent article (1) includes at least one fastening tab (2) positioned along the side edge (6; 12a, 12b). In a first position the fastening tab (2) is folded over itself at least once creating at least one first pleat (13) and secured in its folded position by fastening means (17) positioned in the first pleat (13) on only a first side (14) of the fastening tabs (2), and in that in a second position, the fastening tab (2) is arranged to be unfolded at least partly for attachment to the outside and/or the inside of an undergarment (21).
US08419701B2 Absorbent articles with stretch zones comprising slow recovery elastic materials
An absorbent article may have at least one stretch zone comprising a slow recovery elastomer wherein the slow recovery elastomer exhibits a normalized unload force of greater than about 0.04 N/mm2 at 37° C.; and the slow recovery elastomer exhibits at least about 20% post elongation strain at 22° C. after 15 seconds of recovery from a 400% strain. The absorbent article may additionally comprises one or more of a liquid permeable topsheet, a liquid impermeable backsheet, an absorbent core, an ear, a side panel, a waist feature, a fastener component, a leg cuff, a gasketing cuff, and a barrier cuff, wherein the feature comprises at least a part of the stretch zone.
US08419700B2 Tampon overwrap
A packaged elongate intravaginal device has an overwrap substantially enclosing the device. The overwrap has a longitudinal overlap seam disposed generally parallel to the longitudinal axis. The seam includes one ply of overwrap material disposed at a first margin of a overwrap blank superposed on a second ply of overwrap material disposed at a second margin of the overwrap blank, opposite the first. The overwrap has a substantially continuous line of weakness that intersects a plane including the longitudinal axis of the packaged device at at least three unique locations. The line of weakness extends across the longitudinal overlap seam and includes weakness components superposed in each ply of the overlap seam, and the line of weakness is arranged and configured in a manner to permit the overwrap to remain as a unitary structure upon destruction of the line of weakness.
US08419697B2 Liquid collection system and related methods
Various embodiments of a fluid collection system having multiple storage chambers are disclosed. In an exemplary embodiment, the system may include a first chamber in fluid communication with a suction source and a second chamber in fluid communication with the first chamber. The second chamber may have a volume less than a volume of the first chamber. The second chamber may also comprise an inlet port for connecting to an external tube. The system may be configured to selectively drain liquid from the second chamber into the first chamber.
US08419695B2 Apparatus and method of maintaining insufflation
An apparatus includes a body configured to be at least partially inserted into a rectum of a patient. The body defines a first passageway and a second passageway between a proximal end portion and a distal end portion. The first passageway is configured to receive a medical tool and the second passageway is configured to communicate an insufflation medium. An insufflation port is coupled to the second passageway and is configured to communicate the insufflation medium to the second passageway. A retention portion is coupled to the body and is configured to have a dimension transverse to an axis defined by the body sufficient to retain at least a portion of the body in the rectum. The retention portion is configured to be located beyond an anus of the patient.
US08419694B2 Extension tube clamps for use with a catheter
A clamping assembly includes a first clamping member and a second clamping member. The first clamping member defines a first lumen dimensioned to non-rotatably engage a first portion of a tubular member. Rotating the first clamping member effects a rotation of the first portion of the tubular member. The second clamping member defines a second lumen dimensioned to non-rotatably engage a second portion of the tubular member. Rotating the second clamping member in relation to the first clamping member rotates the second portion of the tubular member in relation to the first portion of the tubular member to twist the tubular member to restrict flow through the tubular member.
US08419689B2 Enclosing package for medical port and cover
A securement device for securing a catheter to a patient is provided. The securement device includes a base including a support member and at least one securement arm extending away from the support member. The support member defines a cradle portion, the cradle portion of the support member being configured to receive at least a portion of a catheter. The at least one securement arm being movable over the cradle portion to a position to secure a catheter within the cradle portion. The securement device further includes a cover member configured to be received over the base and dimensioned to secure the base to a patient.
US08419687B2 Device for shielding a sharp tip of a cannula and method of using the same
A safety device for shielding a sharp tip of a tubular needle includes a shaft sized and shaped for being received into the passage of the tubular needle through a first end of the passage and extending to a second end of the passage. A shield is associated with the shaft and is constructed for receiving and substantially shielding the sharp tip of the needle. A catch is associated with the shaft. The catch prevents the withdrawal of the shaft from the passage of the needle when the shield is shielding the sharp tip of the needle.
US08419677B2 Balloon-tipped endoscopic system
Multi-luminal endoscopic systems for sterilely delivering deployable devices or obtaining bodily tissues. The system comprise an outer catheter comprising a wall that encloses an outer lumen; an inner catheter movably disposed within the outer lumen and having an inner lumen; a balloon-tipped catheter movably disposed within the inner lumen and having a distal end and a proximal end, wherein the distal end of the balloon-tipped catheter comprises a balloon tip that can be expanded to contact the wall of the outer catheter to provide a seal to prevent bodily fluids from entering the outer lumen; and a push catheter having a lumen and is located within the outer lumen. The delivery systems can comprise concentric catheters. Systems used for tissue collecting can comprise catheters with different common center.
US08419675B2 Applicator
An applicator insertable into a living body includes a nozzle having an elongated nozzle main body and a nozzle head on a front end side of the nozzle main body and through which a liquid together with a gas is expelled, with the nozzle main body including a flexible curved section. The applicator also includes an outer tube in which is positioned a portion of the nozzle main body so as to be movable along a longitudinal direction. The angle or degree of curvature of the curved section is changed by inserting the curved section into the outer tube to thereby adjust a direction of the nozzle head relative to a axis of the nozzle main body. In addition, a longitudinally extending gap exists between the outer tube and the nozzle. The gap functions as a discharge path for discharging gas within the body cavity.
US08419670B2 Frame for an orthopedic brace having a truss structure and an associated strapping system
A frame is provided for an orthopedic brace having an upper frame assembly, a lower frame assembly, a first hinge and a second hinge. The first and second hinges dynamically connect the upper and lower frame assemblies. The upper or lower frame assembly includes a truss unit which defines a triangle. The first side of the triangle is a substantially vertical longitudinal strut. The second side of the triangle is a first cross beam which is substantially horizontal or diagonal. The third side of the triangle is a diagonal second cross beam.
US08419669B2 Brace hinge with telescoping condyle pad
A knee brace assembly is provided having an adjustable, pressure-applying gear system mounted to a portion of the hinge assembly. Through selective adjustment of the gear system, the knee brace assembly can apply pressure to a portion or portions of the knee joint, thereby relieving pressure on the knee joint. A method of treating a knee joint using a knee brace assembly including a planetary gear system is also provided.