Document Document Title
US07741726B2 Integrated circuit underfill package system
An integrated circuit underfill package system including providing a substrate having a dispense port, attaching a first integrated circuit die on the substrate, and supplying an underfill to the dispense port when the substrate and the first integrated circuit die are inverted.
US07741723B2 Semiconductor device comprising chip on chip structure
In a semiconductor device constituted of stacked semiconductor chips, in order to independently test each of the chips, a second chip is disposed to face a first chip, with a second interconnection terminal thereof connected to a first interconnection terminal of the first chip. First and second external terminals of the first and second chips are formed on surfaces of the first and second chips, the surface being on a same side of the first and second chips. Therefore, even after the first chip and the second chip are pasted together, it is possible to test the first chip and the second chip while operating them independently. Further, since test probes or the like can be brought into contact with the external terminals of the first chip and the second chip from the same side, it is possible to simultaneously test the first chip and the second chip.
US07741718B2 Electronic apparatus interconnect routing
Apparatus are provided for routing interconnects of a dual-gate electronic device operating in a differential configuration. An electronic apparatus formed on a substrate is provided comprising a first interconnect (40, 42, 44) configured to couple to a first region of the substrate, a first gate (22, 24, 26, 28) coupled to the first interconnect and configured to receive a first differential input, a second interconnect (30, 32, 34, 36, 38) parallel to the first interconnect and configured to couple to a second region of the substrate, and a second gate (20) coupled to the second interconnect and configured to receive a second differential input. The first gate is parallel to the first interconnect, and the second gate is parallel to the second interconnect.
US07741716B1 Integrated circuit bond pad structures
Integrated circuit bond pads are provided for forming wire bonds to integrated circuit package pins. Each pad uses a bond pad structure that provides room for under-pad circuitry. The under-pad circuitry can be connected to other circuitry on the integrated circuit, thereby providing efficient use of circuit real estate. The bond pad structures are formed in the dielectric stack portion of the integrated circuit using dummy bond pads and bond pad support structures. Bond pad support structures may be formed from metal in metal interconnect layers. Vias may be used to connect the bond pad support structures to each other and to the dummy bond pads. Bond pad support structures may be formed in a polysilicon layer at the bottom of the dielectric stack. A contact layer contains metal plugs that connect the polysilicon bond pad support structures to the lowermost metal-layer bond pad support structures.
US07741715B2 Crack stop and moisture barrier
A design for a crack stop and moisture barrier for a semiconductor device includes a plurality of discrete conductive features formed at the edge of an integrated circuit proximate a scribe line. The discrete conductive features may comprise a plurality of staggered lines, a plurality of horseshoe-shaped lines, or a combination of both.
US07741713B2 Semiconductor device and method of manufacturing the same
After a plurality of pads (2) are formed on an insulation film (1), a passivation film (3) is formed on the entire surface thereof, and opening parts (3a) which exposes all the pads (2) are formed in the passivation film (3). Next, another passivation film is formed on the entire surface and, for each of the pads (2), an opening part is formed in this passivation film to expose the central portion of the pad (2). According to the above method, the probing test can be performed with the opening parts (3a) formed in the passivation film (3). Performing the probing test in such a state increases the probability that the probe contacts the pad (2) since the entire surface of the pad (2) is exposed, thereby providing the test with a higher accuracy. Thus, the pad can be miniaturized and/or the pitch can be narrowed without requiring a higher accuracy of the probe.
US07741712B2 Semiconductor device, circuit substrate, electro-optic device and electronic appliance
A semiconductor device in the first embodiment includes: an electrode pad and a resin projection, formed on an active surface; a conductive film deposited from a surface of the electrode pad to a surface of the resin projection; a resin bump formed with the resin projection and with the conductive film. The semiconductor device is conductively connected to the opposing substrate through the resin bump electrode. The testing electrode is formed with the conductive film that is extended and applied to the opposite side of the electrode pad across the resin projection.
US07741711B2 Power semiconductor module with a connected substrate carrier and production method therefor
A power semiconductor module includes a housing, a substrate carrier with a circuit thereon and electrical connection elements extending therefrom. The carrier has a cutout between its inner surface (facing the interior of the module) and its outer surface. The cutout is smaller at the inner surface than at the outer surface. The housing has an extension that reaches into the cutout and may be deformed to form a riveted connection. The method comprises: forming a housing with at least one extension which extends towards the exterior of the module, wherein the extension projects through the cutout and beyond the outer surface of the carrier; and deforming the end of the extension so that it widens and forms a riveted connection and at the same time lies below the outer surface of the carrier.
US07741703B2 Electronic device and lead frame
A lead frame facilitates the handling, positioning, attachment, and/or continued integrity of multiple dies, without the use of multiple separate parts, such as jumpers. The lead frame includes a number of structures, each of which is attached to at least one lead. At least one receiving surface, arranged to receive a die, is associated with each structure. When dies are disposed on the receiving surfaces, anodes are similarly-oriented. A number of fingers are attached to the lead frame, and one or more electrode contact surfaces are attached to each finger. Each electrode contact surface can be positioned (for example, bent) with respect to one receiving surface, to facilitate electrical connection between the anode of a die and a lead. The lead frame may be used in connection with surface- and through-hole-mountable electronic devices, such as bridge rectifier modules.
US07741702B2 Semiconductor structure formed using a sacrificial structure
A semiconductor structure is provided which eliminates the contact resistance traditionally associated with a junction between one or more contacts and a buried conductive structure formed in the semiconductor structure. The semiconductor structure includes a first insulating layer formed on a semiconductor layer and a conductive structure formed on at least a portion of the first insulating layer. A second insulating layer is formed on at least a portion of the conductive structure. At least one contact is formed through the second insulating layer and electrically connected to the conductive structure. The contact and the conductive structure are formed as a substantially homogeneous structure in a same processing step.
US07741698B2 Post last wiring level inductor using patterned plate process
A semiconductor structure. The semiconductor structure includes: a substrate having a metal wiring level within the substrate; a capping layer on and above a top surface of the substrate; an insulative layer on and above a top surface of the capping layer; an inductor comprising a first portion in and above the insulative layer and a second portion only above the insulative layer; and a wire bond pad within the insulative layer, wherein the first portion the inductor has a height in a first direction greater than a height of the wire bond pad in the first direction, wherein the first direction is perpendicularly directed from the top surface of substrate toward the insulative layer.
US07741695B2 Semiconductor device
Extending from an upper surface of an n− semiconductor layer on a p− semiconductor substrate to the interface between the n− semiconductor layer and the p− semiconductor substrate, a p+ impurity region is provided. The p+ impurity region defines a high-potential island region, a low-potential island region and a slit region in the n− semiconductor layer. The n− semiconductor layer in the high-potential island region and the n− semiconductor layer in the low-potential island region are connected by the n− semiconductor layer in the slit region, and a logic circuit is formed in the n− semiconductor layer in the high-potential island region. A width in the direction of Y axis of the n− semiconductor layer in the slit region is set to be narrower than a width in the direction of the Y axis of the n− semiconductor layer in the high-potential island region.
US07741693B1 Method for integrating trench MOS Schottky barrier devices into integrated circuits and related semiconductor devices
Trenches are formed in a semiconductor substrate, where the trenches include an outer trench and multiple inner trenches within the outer trench. A metal-oxide semiconductor (MOS) device and a trench MOS Schottky barrier (TMBS) device are also formed in the semiconductor substrate using the trenches. The MOS device could include the outer trench, and the TMBS device could include the inner trenches. At least one of the inner trenches may contact the outer trench, and/or at least one of the inner trenches may be electrically isolated from the outer trench. The MOS device could represent a trench vertical double-diffused metal-oxide semiconductor (VDMOS) device, and the TMBS device may be monolithically integrated with the trench VDMOS device in the semiconductor substrate. A guard ring that covers portions of the inner trenches and that is open over other portions of the inner trenches could optionally be formed in the semiconductor substrate.
US07741688B2 Magnetic random access memory and method of manufacturing the same
A magnetic random access memory includes a magnetoresistive effect element having a fixed layer in which a magnetization direction is fixed, a recording layer in which a magnetization direction is reversible, and a nonmagnetic layer formed between the fixed layer and the recording layer, a hollow portion being formed in a center of the recording layer, and the magnetization directions in the fixed layer and the recording layer taking one of a parallel state and an antiparallel state in accordance with a direction of an electric current supplied between the fixed layer and the recording layer, an insulating layer formed in the hollow portion, a wiring connected to one terminal of the magnetoresistive effect element, and a transistor connected to the other terminal of the magnetoresistive effect element.
US07741686B2 Trench isolated capacitive micromachined ultrasonic transducer arrays with a supporting frame
A one or two-dimensional capacitive micro-machined ultrasonic transducer (CMUT) array with supporting frame is provided. The CMUT array has at least three array elements deposited on a conductive substrate. The invention also has at least one CMUT cell in the array element, a conductive top layer deposited to a top side of the element, and a conductive via disposed within the elements. The via is isolated from the conductive top layer and conducts with the substrate. There are at least two isolation trenches in the conductive substrate, and the trenches are disposed between adjacent vias to conductively isolating the vias. A substrate region between the trenches forms a mechanical support frame. At least one conductive electrode is deposited to a bottom surface of the conductive substrate, where the electrode conducts with the via. The support frame eliminates the need for a carrier wafer in the process steps.
US07741682B2 Semiconductor integrated circuit device including a silicon layer formed on a diffusion layer
A semiconductor integrated circuit device having a pair of adjacent MOS transistors and a contact plug 33, buried into a contact hole formed by a self-aligned contact process using a silicon nitride film as an etching stopper and electrically connected to diffusion layers 2 and 3 constituting the MOS transistor on a silicon substrate 21 surrounded by a device isolation region 4: wherein a silicon layer 28 is formed on the exposed surface of the diffusion layers 2 and 3 by selective epitaxial growth, which is in contact with an end of each gate insulation film 22 on the diffusion layer side; an insulation film 27′ composed of a silicon oxynitride film or a silicon oxide film is buried between the each gate electrode and the silicon layer 28 while being in contact with the gate insulation film 22; and the silicon nitride films 26, 29′, and 32 are isolated from the silicon substrate 21 by the insulation film 27′.
US07741681B2 Latchup robust array I/O using through wafer via
A structure and a method for preventing latchup. The structure including: an I/O cell and an ESD protection circuit in a region of an integrated circuit chip containing logic circuits; an electrically conductive through via extending from a bottom surface of the substrate toward a top surface of the substrate between the I/O cell and an ESD protection circuit and at least one of the logic circuits.
US07741679B2 Semiconductor device, method of manufacturing same and method of designing same
A partial oxide film with well regions formed therebeneath isolates transistor formation regions in an SOI layer from each other. A p-type well region is formed beneath part of the partial oxide film which isolates NMOS transistors from each other, and an n-type well region is formed beneath part of the partial oxide film which isolates PMOS transistors from each other. The p-type well region and the n-type well region are formed in side-by-side relation beneath part of the partial oxide film which provides isolation between the NMOS and PMOS transistors. A body region is in contact with the well region adjacent thereto. An interconnect layer formed on an interlayer insulation film is electrically connected to the body region through a body contact provided in the interlayer insulation film. A semiconductor device having an SOI structure reduces a floating-substrate effect.
US07741676B2 Semiconductor apparatus and manufacturing method using a gate contact section avoiding an upwardly stepped polysilicon gate contact
A semiconductor apparatus includes a cell section including at least two transistors. A layer interval insulation coat is formed at least overlying the gate electrode use polysilicon and the gate contact use polysilicon. A source electrode metal coat is formed overlying the semiconductor substrate and insulated from the gate electrode use polysilicon and the gate contact use polysilicon, and is electrically connected to the body diffusion layer and the source diffusion layer. A gate use connection hole is formed on the layer interval insulation coat overlying the gate contact use polysilicon. The gate use connection hole has a width larger than that of the trench. A gate electrode metal coat is formed on the gate use connection hole and the layer interval insulation coat. The polysilicon coat is formed at the same level or lower than the surface of the semiconductor substrate.
US07741670B2 Semiconductor decoupling capacitor
A semiconductor capacitor that includes a plurality of overlapping conductive layers and a field-effect transistor. The plurality of conductive layers include a first and second conductive layers that are spaced apart to creating a capacitance between the plurality of layers. In the semiconductor capacitor, the FET has a source, a drain and a gate. When the FET is in conduction mode, a capacitance is created between the gate and the conductive path in the semiconductor substrate between the source and the drain. The semiconductor capacitor's total capacitance is increased by coupling the drain and the source to the first conductive layer and coupling the gate to the second conductive layer.
US07741667B2 CMOS image sensor for improving the amount of light incident a photodiode
Provided are a CMOS image sensor and a fabricating method thereof. The CMOS image sensor includes a device isolation layer, a plurality of photodiode regions, an interlayer insulating layer, a refracting layer, a planarizing layer, a color filter layer, and a plurality of microlenses. The refracting layer, with a higher refractive index than that of the interlayer insulating layer, is formed through the interlayer insulating layer on portions of the device isolation layer, to divide the interlayer insulating layer and give the divided portions thereof the characteristics of a waveguide.
US07741666B2 Backside illuminated imaging sensor with backside P+ doped layer
A backside illuminated imaging sensor includes a semiconductor layer having a P-type region. A frontside and backside P+ doped layers are formed within the semiconductor layer. An imaging pixel having a photodiode is formed within the semiconductor layer, where the photodiode is an N− region formed within the P-type region of the semiconductor layer between the frontside P+ doped layer and the backside P+ doped layer.
US07741665B2 High-quality CMOS image sensor and photo diode
Provided are a high-quality CMOS image sensor and a photo diode, which can be fabricated in sub-90 nm regime using nanoscale CMOS technology. The photo diode includes: a p-type well; an internal n-type region formed under a surface of the p-type well; and a surface p-type region including a highly doped p-type SiGeC epitaxial layer or a polysilicon layer deposited on a top surface of the p-type well over the internal n-type region. The image sensor includes: a photo diode including an internal n-type region and a surface p-type region; a transfer transistor for transmitting photo-charges generated in the photo diode to a floating diffusion node; and a driving transistor for amplifying a variation in an electric potential of the floating diffusion node due to the photo-charges. The image sensor further includes a floating metal layer for functioning as the floating diffusion node and applying an electric potential from a drain of the transfer transistor to a gate of the driving transistor.
US07741661B2 Isolation and termination structures for semiconductor die
Various integrated circuit devices, including a lateral DMOS transistor, a quasi-vertical DMOS transistor, a junction field-effect transistor (JFET), a depletion-mode MOSFET, and a diode, are formed inside an isolation structure which includes a floor isolation region and a trench extending from the surface of the substrate to the floor isolation region. The trench may be filled with a dielectric material or may have a conductive material in a central portion with a dielectric layer lining the walls of the trench. Various techniques for terminating the isolation structure by extending the floor isolation region beyond the trench, using a guard ring, and a forming a drift region are described.
US07741660B2 Pixel and imager device having high-k dielectrics in isolation structures
An imager device that has an isolation structure such that pinned photodiode characteristics are maintained without increasing doping levels. The invention provides an isolation structure to maintain pinned photodiode characteristics without increasing doping levels around the photodiode. By creating a substrate region surrounding the charge-collection region of the photodiode, the photodiode may be electrically isolated from the bulk substrate. This region fixes the depletion region so that it does not migrate toward the surface of the substrate or the STI region. By doing so, the region prevents charge from being depleted from the substrate and the accumulation region, reducing dark current.
US07741654B2 Group III nitride semiconductor optical device
The present invention provides a semiconductor laser excellent in the current injection efficiency. In an inner stripe type semiconductor laser according to the present invention, a p type cladding layer 309 has a superlattice structure composed of GaN layers and Al0.1Ga0.9N layers, which are alternately layered on each other. The p type cladding layer 309 has a portion of high dislocation density and a portion of low dislocation density. That is, the dislocation density is relatively low in a region directly above an opening of the current-confining region 308, whereas the dislocation density is relatively high in a region directly above a current-confining region 308.
US07741650B2 Illuminating equipment of high-power and clustered light-emitting diodes coupled to high efficiency heat-spreading and heat-dissipating module
The invention discloses a light-emitting diode illuminating equipment. The light-emitting diode illuminating equipment of the invention includes a heat-dissipating plate device, a plurality of heat-dissipating fins, a plurality of diode light-emitting devices, and a plurality of bar-shaped heat-conducting devices with high heat-conducting coefficient. The heat-dissipating fins extend from a surface of the heat-dissipating plate device. By mounting the heat-conducting devices onto the surface of the heat-dissipating plate device and disposing them among the heat-dissipating fins, a heat produced in operation by each diode light-emitting device is distributed uniformly on the heat-dissipating plate device and the heat-conducting devices due to the high heat-conducting efficiency of the heat-conducting devices, and then it is dissipated such that the diode light-emitting devices have a consistent junction temperature to make a consistency of luminous efficiency and lifetime of the diode light-emitting devices.
US07741646B2 Liquid crystal display device and fabricating method thereof
A liquid crystal display panel and a fabricating method thereof comprising an image sensing capability, image scanning, and touch inputting. In the liquid crystal display device, a gate line and a data line are formed to intersect each other on a substrate to define a pixel area in which a pixel electrode is positioned. A first thin film transistor is positioned at an intersection area of the gate line and the data line. A sensor thin film transistor senses light having image information and supplied with a first driving voltage from the data line. A driving voltage supply line is positioned in parallel to the gate line to supply a second driving voltage to the sensor thin film transistor.
US07741644B2 Semiconductor device having stacked transistors
A semiconductor device includes a first semiconductor layer, a first interlayer insulation layer, a second semiconductor layer, and a gate pattern. The first interlayer insulation layer covers the first semiconductor layer. The second semiconductor layer is formed on the first interlayer insulation layer and includes source regions, drain regions, and a channel region interposed between the source region and the drain region. The gate pattern includes a gate insulation layer on the channel region of the second semiconductor layer. At least one of the source regions and the drain regions includes an elevated layer having a top surface higher than that of the channel region.
US07741641B2 TFT substrate and display device having the same
A TFT substrate includes a base substrate, a gate wiring formed on the base substrate, a gate insulation layer, an activation layer, an oxidation-blocking layer, a data wiring, a protection layer and a pixel electrode. The gate wiring includes a gate line and a gate electrode. The gate insulation layer is formed on the base substrate to cover the gate wiring. The activation layer is formed on the gate insulation layer. The oxidation-blocking layer is formed on the activation layer. The data wiring includes a data line, a source electrode and a drain electrode. The source and drain electrodes are disposed on the oxidation-blocking layer therefore lowering the on-current (“Ion”) for turning on the TFT and increasing the off-current (“Ioff”) for turning off the TFT due to the oxidation-blocking layer.
US07741639B2 Multi-chambered excimer or molecular fluorine gas discharge laser fluorine injection control
A multi-chambered excimer or molecular halogen gas discharge laser system comprising at least one oscillator chamber and at least one amplifier chamber producing oscillator output laser light pulses that are amplified in the at least one power chamber, having a fluorine injection control system and a method of using same is disclosed, which may comprise: a halogen gas consumption estimator: estimating the amount of halogen gas that has been consumed in one of the at least one oscillator chamber based upon at least a first operating parameter of one of the least one oscillator chamber and the at least one amplifier chamber, and the difference between a second operating parameter of the at least one oscillator chamber and the at least one amplifier chamber, and estimating the amount of halogen gas that has been consumed in the other of the at least one oscillator chamber and the at least one amplifier chamber based upon at least a third operating parameter of the other of the at least one oscillator chamber and the at least one amplifier chamber, and producing an output representative of an estimated halogen gas consumption in the at least one oscillator chamber and of the halogen gas consumption in the at least one amplifier chamber, and a halogen gas injection controller determining the amount of halogen gas injection for the at least one oscillator chamber and the at least one amplifier chamber based upon the estimated fluorine consumption outputs from the fluorine consumption estimator and a cost function comprising a plurality of weighted injection decision determinations.
US07741634B2 Josephson junction device for superconductive electronics with a magnesium diboride
A Josephson junction (JJ) device includes a buffered substrate comprising a first buffer layer formed on a substrate. A second buffer layer is formed on the first buffer layer. The second buffer layer includes a hexagonal compound structure. A trilayer structure is formed on the buffered substrate comprising at least two layers of a superconducting material. A thin tunnel barrier layer is positioned between the at least two layers. The buffered substrate is used to minimize lattice mismatch and interdiffusion in the trilayer structure so as to allow the JJ device to operate above 20 K.
US07741632B2 InGaAIN light-emitting device containing carbon-based substrate and method for making the same
One embodiment of the present invention provides an InGaAlN-based semiconductor light-emitting device which comprises an InGaAlN-based semiconductor multilayer structure and a carbon-based substrate which supports InGaAlN-based semiconductor multilayer structure, wherein the carbon-based substrate comprises at least one carbon-based layer. This carbon-based substrate has both high thermal conductivity and low electrical resistivity.
US07741622B2 Exposure device
The present invention presents an exposure device, which includes an optical source for emitting a UV ray, a lighting system for shaping the UV ray into a collimated light beam, an aperture member for producing rectangular first and second light beams based on the light beam from lighting system by using the first and second rectangular windows, first and second spatial light modulators for spatially modulating the first and second light beams, respectively, and first and second projection lighting systems for guiding the modulated first and second light beams to the object.
US07741621B2 Apparatus and method for focused electric field enhanced plasma-based ion implantation
There is disclosed an apparatus and method for focused electric field enhanced plasma-based ion implantation. The apparatus includes an implantation chamber, a vacuum pump for maintaining the pressure in the implantation chamber at a desired level, a sample holder, means for applying a negative potential to the sample holder, and means for supplying a gaseous or vaporized implantation material. The supplying means takes the form of a feed conduit having an exit opening located in the implantation chamber above the sample holder, and when a negative potential is applied to the sample holder the exit opening of the feed conduit is maintained at a potential that is positive relative to the sample holder.
US07741619B2 Scintillator panel for radiation, and flat panel detector
An objective is to provide a flat panel detector exhibiting high durability and less noise, which is fitted with a scintillator for radiation exhibiting high emission efficiency, wherein the scintillator is easy to be manufactured because of the simple structure. Also disclosed is a scintillator panel for radiation possessing a radiotransparent substrate and provided thereon, a phosphor layer from which light is emitted by exposing the substrate to radiation and a reflective film at which light from the phosphor layer is reflected, wherein the reflective film provided between the substrate and the phosphor layer possesses a multilayer film composed of at least two dielectric layers exhibiting a high reflectivity.
US07741617B2 Fluid treatment system
There is disclosed a fluid treatment device comprising a housing for receiving a flow of fluid. The housing comprises a fluid inlet, a fluid outlet, a closed fluid treatment zone disposed between the fluid inlet and the fluid outlet. Disposed in the housing is at least one elongate radiation source assembly having a longitudinal axis disposed in the fluid treatment zone substantially parallel to a direction of the flow of fluid through the housing. The radiation source assembly comprises an elongate radiation source disposed in a protective sleeve to define a substantially annular passageway. The protective sleeve has opposed open ends configured to permit heat to exit the passageway and the housing through at least one of the opposed open ends of the sleeve.
US07741615B2 High energy crystal generators and their applications
Ferroelectric, pyroelectric and piezoelectric crystals are used to generate spatially localized high energy (up to and exceeding 100 keV) electron and ion beams, which may be used in a wide variety of applications including pulsed neutron generation, therapeutic X-ray/electron devices, elemental analysis, local scanning chemical analysis, high energy scanning microscopy, point source compact transmission electron microscopy, compact ion beam sources, positron sources, micro-thrusters for ion engines, and improved fusion efficiency especially of the Farnsworth type. The high-energy emission can be created by simply heating the material or by application of external coercive electromagnetic and acoustic fields.
US07741611B2 Radiation detector power management for portable/handheld applications
A radiation detector includes at least one multiple channel pixelated detector driven via a plurality of pixelated anode electrodes and at least one planar cathode electrode. Each detector is configured to reduce the number of active pixelated anode electrodes until a rate of events detected via at least one corresponding planar cathode electrode exceeds a preset threshold above a background count rate within a predetermined time period.
US07741608B2 Image reader
In an image reader, if a first and second light sources alternately light-up when a conveying unit conveys an imaging target medium, a visible light data group that is based on a reflected light, of a wavelength inside a visible spectrum, of a first light having a wavelength inside the visible spectrum and a visible light external data group that is based on the reflected light, of the wavelength inside the visible spectrum, of a second light having a wavelength outside the visible spectrum are alternately generated. By scanning the imaging target medium once and by collecting multiple visible light data group, first image data of the imaging target medium, based on the first light, is generated. Furthermore, by collecting multiple visible light external data group, second image data of the imaging target medium, based on the second light, is also generated.
US07741607B2 Modular signal processing backbone for PET
An imaging system (2) having a scalable event processing architecture includes a plurality of detector modules (4) arranged around an associated imaging region (8) to detect radiation events emitted from a subject disposed within the imaging region (8); a plurality of sets of processing elements (6), each set including processing elements of at least one of the plurality of radiation detector modules (4), each processing element (6) time-stamping an associated detected radiation events; and inserting the time-stamped event into a chronological position within a data stream (10) of events; and coincident detecting circuitry (22, 54) that receives the chronologically ordered stream of events and detects coincident pairs of events for use in reconstructing one or more associated images of the object.
US07741594B2 Electromagnetic wave detector with an optical coupling surface comprising lamellar patterns
The invention relates to a detector comprising a multiple quantum well structure operating on interband or intersubband transitions by absorption of radiation having a wavelength λ having a polarization comprising a component perpendicular to the plane of the multiple quantum well structure, and comprising optical coupling means for coupling said radiation, wherein the coupling means comprise a set of first diffractive lamellar features that are distributed along at least a first direction and a set of second diffractive lamellar features that are distributed along at least a second direction, said first and second directions being mutually perpendicular and lying in a plane parallel to the plane of the multiple quantum well structure.
US07741592B1 Physiological sensor with booster circuit
A physiological sensor includes a light source in optical communication with a light detector. A controller is in communication with the light detector via a connector. A booster circuit is in communication with the light detector and the connector. The booster circuit may be configured to buffer signals generated by the light detector and reduce an input capacitance on either the controller or terminals of the connector. In various embodiments, the booster circuit may be disposed on the connector for a reusable cable or a disposable sensor pad.
US07741589B2 Method and apparatus providing multiple transfer gate control lines per pixel for automatic exposure control
An imager device includes a pixel array having some pixels providing output signals for automatic light control with other pixels providing image output signals. Multiple pixel cells of the array may be arranged to obtain sample data indicating the amount of light reaching the array, while image pixels in the array provide captured image data. An exemplary device includes a CMOS pixel array having 4T pixels arranged in rows and columns and having two transfer transistor control lines for each row of the array. Operation of the first transfer transistor line controls the pixels used for ALC operation while operation of the second transfer transistor line controls the pixels used for image capture.
US07741584B2 Encapsulated graphite heater and process
A graphite heater and method of forming a graphite heater comprising a graphite body configured to form an electrical heating circuit for at least one heating zone through the graphite encapsulated in a continuous overcoat layer comprising at least one of a nitride, carbide, carbonitride or oxynitride of elements selected from a group consisting of B, Al, Si, Ga, refractory hard metals, transition metals, and rare earth metals, or complexes and/or combinations thereof, wherein prior to being configured to form the electrical heating circuit path, the graphite body is coated with a layer comprising at least one of a nitride, carbide, carbonitride or oxynitride of elements selected from a group consisting of B, Al, Si, Ga, refractory hard metals, transition metals, and rare earth metals, or complexes and/or combinations thereof.
US07741581B2 Heatable steering wheel
A heatable steering wheel includes a steering wheel blank, a heating mat wrapped around the steering wheel blank, a first, visible hard sheathing whose surface is refinished after having been installed, a second, visible softer sheathing, both of the sheathings abutting each other in an abutting area, and a coupling element in the abutting area. The coupling element, as seen from the outside, has a depression and that, starting from the first sheathing, extends under the abutting area all the way to an abutting edge of the second sheathing. The heating mat extends continuously under the first sheathing and under the coupling element all the way to under the second sheathing.
US07741580B2 Method of welding a pipe/connector joint
A method for welding a pipe section and a connector, where each of the pipe and connector have inner and outer beveled surfaces forming only a single angular alignment land when mated. The pipe and connector are welded together with only a single interior welding pass and with more than one exterior welding pass to fill the weld joints at the outer beveled surface, so as to weld the connector to the pipe.
US07741576B2 Apparatus and method for hybrid machining a workpiece
An apparatus and method for hybrid machining a workpiece is disclosed. The apparatus includes a mandrel for supporting the workpiece adjacent a cutter mounted on an arbor. A workpiece is powered as an anode and the cutter is powered as a cathode, and a cutting fluid or coolant is circulated therebetween. The cutter is made of a conductive material and a non-conductive abrasive material to maximize the amount of material removed from the workpiece. The coolant includes one or more additives to enhance the electrical discharge between the cutter and the workpiece. The cutter is moved relative to the workpiece to remove material from the workpiece at a predetermined depth of cut using an enhanced high-speed electro-erosion (HSEE) process in which both HSEE and abrasive machining processes are used. The workpiece may then be finish machined to a final shape of the titanium article, such as a dovetail of a turbine blade.
US07741569B2 Electronic weight scale
An electronic weight scale includes: a main scale module including a main weight sensor disposed in a main housing and outputting an output corresponding to weight acting on the main housing and sensed thereby, a controller operable in one of folded and unfolded modes in response to a control signal from an input unit, and a display unit mounted on the main housing; and an auxiliary scale unit connected pivotally to the main scale module and including an auxiliary scale module that has an auxiliary weight sensor disposed in an auxiliary housing and outputting an output corresponding to weight acting on the auxiliary housing and sensed thereby. The controller outputs weight information, that indicates the output from the main weight sensor when in the folded mode and that indicates a sum of the outputs from the main and auxiliary weight sensors when in the unfolded mode, to the display unit.
US07741564B2 Electrical wire and method of making an electrical wire
An electrical wire has conductor and a covering. The covering includes a thermoplastic composition having a poly(arylene ether), a polyolefin and a polymeric compatibilizer. The thermoplastic composition may further have a flame retardant.
US07741563B2 Closed type cable or the like protection and guide device
A closed type cable or the like protection and guide device that reduces noise generation due to the generation of sliding contact sound during operation prevents entry of fine chips and wear powders of metal into the cable or the like protection and guide device. Scattering of contact wear powders, which are generated by sliding contact between components of the cable or the like protection and guide device, into the operation space can be prevented and a maintenance of the device is reduced. A cable or the like is included in a flexible support to be protected and guided from a fixed end side mounting member toward a movable end side mounting member and the entire outer surface of the flexible support except for an inlet and an outlet of the cable or the like is covered with a heat resistant tubular cloth cover.
US07741562B2 Wall plate assembly with integral universal serial bus module
A wall plate assembly including a wall plate with an integrated USB module. The assembly includes a USB connector and printed circuit board formed together on the wall plate as an integral whole such that USB extender circuitry is situated directly on, or is formed as part of, the printed circuit board. A quick-connect coupling enables fast electrical connection and disconnection with a complementary quick-connect coupling on a USB wire.
US07741560B2 Chalcopyrite solar cell
A chalcopyrite solar cell having a mica substrate or a laminated mica substrate, an intermediate layer made of a ceramic-based material formed on the mica substrate, and a binder layer formed on the intermediate layer. The intermediate layer has a thickness equal to or more than 2 μm and equal to or less than 20 μm. The binder layer has a thickness equal to or more than 3000 Å and equal to or less than 8000 Å. The intermediate layer and the binder layer are interposed between the mica substrate and a molybdenum electrode.
US07741555B2 Hybrid wind musical instrument and electric system for the same
A hybrid wind musical instrument is a combination of an alto saxophone and an electronic system, and a player has an option between acoustic tones and electronic tones to be produced during performance; the electronic system includes sensors monitoring selected component parts of the key mechanism so as to determine the electronic tones intended to be produced by the player, and plural combinations of pieces of magnet and Hall-effect elements serve as the sensors: However, the component parts of key mechanism are arranged in a narrow space over the surface of tubular instrument body; driven parts are attached to the selected component parts so as to bridge gap between the selected component parts and the Hall-effect elements remote from the selected component parts.
US07741553B2 White key for keyboard musical instrument
A white key for a keyboard musical instrument comprises a key body made of resin in the form of a hollow box shape having an upper wall to be pressed by an instrument player and vertical walls extending downward from the periphery of the upper wall. The upper wall of the key includes a wide part and a narrow part, the narrow part providing a space to accommodate a black key. The upper wall has a thickness not exceeding 1.5 mm and the wide part has a projection extending from the upper wall downward. The projection may be in the form of a rib bridging the vertical walls or of columns extruding from the lower surface of the upper wall. The frequency band of a vibration mode due to a deformation of the upper wall caused when struck by the player's finger is shifted higher when compared with the case where no projection is provided.
US07741544B1 Inbred corn line G07-NPIC3426
Basically, this invention provides for an inbred corn line designated G07-NPIC3426, methods for producing a corn plant by crossing plants of the inbred line G07-NPIC3426 with plants of another corn plants. The invention relates to the various parts of inbred G07-NPIC3426 including culturable cells. This invention also relates to methods for introducing transgenic transgenes into inbred corn line G07-NPIC3426 and plants produced by said methods.
US07741543B2 Cotton variety 03H070
The invention relates to the novel cotton variety designated 03H070. Provided by the invention are the seeds, plants, plant parts and derivatives of the cotton variety 03H070. Also provided by the invention are tissue cultures of the cotton variety 03H070 and the plants regenerated therefrom. Still further provided by the invention are methods for producing cotton plants by crossing the cotton variety 03H070 with itself or another cotton variety and plants produced by such methods.
US07741538B2 Methods and compositions for expression of transgenes in plants
Methods and compositions for the expression of transgenes in monocot plants including maize are disclosed. In the invention, gene silencing is avoided by use of monocot-homeologous sequences from plants of the genus Coix for transformation. Included in these transgene sequences are Coix promoters, enhancers, coding sequences and terminators. Suitable alternatives to maize-derived transgenes are desirable for expression in maize in that homology-based gene silencing can limit or effectively eliminate transgene expression.
US07741537B2 S-adenosyl-L-methionine synthetase promoter and its use in expression of transgenic genes in plants
A constitutive plant S-adenosyl-L-methionine synthetase (SAMS) promoter and subfragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in plants are described.
US07741536B2 Expression of human serum albumin in plastids
Humans Serum Albumin (HSA) or an HSA fusion protein is expressed in plant plastids. A plastid transformation vector is made which contains an expression cassette that contains regulatory sequences, the coding region for HSA or an HSA fusion protein and a selectable marker coding sequence. The vector is used to transform a plant where the plant expresses the HSA or HSA fusion protein. HSA is isolated and purified from the plant. A preferred plant is tobacco.
US07741535B2 Plant UDP-galactose epimerases
This invention relates to an isolated nucleic acid fragment encoding a UDP-galactose 4-epimerase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the UDP-galactose 4-epimerase, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the UDP-galactose 4-epimerase in a transformed host cell.
US07741529B1 Transgenic animal model for catecholaminergic polymorphic ventricular tachycardia (CPVT) and use thereof
The present invention refers to non-human transgenic mammals, preferably rodents, or mice, which comprise a mutation in the gene encoding for the cardiac ryanodine receptor (RyR2).Transgenic animals carrying the amino acid change R4496C in the RyR2 protein show a phenotype similar to that of Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) (OMIM: 604772). Further provided are methods for using these animals as in vivo model of Catecholaminergic Polymorphic Ventricular Tachycardia and RyR2 dependent arrhythmias, in drug screening and for understanding the molecular basis of RyR2 dependent arrhythmias.
US07741526B2 Feedstock preparation of olefins for oligomerization to produce fuels
A feedstock containing at least 1 wt % butenes, at least 1 wt % pentenes, at least 1 wt % hexenes, at least 10 wppm C4 dienes, at least 10 wppm C5 dienes, and optionally at least 10 wppm C6 dienes can be selectively hydrogenated over a catalyst (e.g., a noble metal) to form a stream containing 100 wppm to 4000 wppm total dienes. The hydrogenated stream, and an olefinic recycle stream having less than 10 wt. % C1+ moieties, can be contacted with a molecular sieve catalyst, e.g., at a recycle to feed ratio between 0.1 and 3.0, at a WHSV of at least 1.0 based on olefin in the feed, and at a reactor ΔT no greater than 40° F. (22° C.), thus forming a reaction product that can then be separated into a distillate, e.g., having from 1 wt % to 30 wt % non-normal C9 olefins, and the aforementioned olefinic recycle stream.
US07741524B2 Iodinated organic substances of low molecular mass and process for preparing them
Process for preparing one or more iodinated organic substances having a molecular mass of less than 2000 (substances (S)) using (A) at least one free-radical-generating substance chosen from peroxides, diazo compounds, dialkyldiphenylalkanes, substances derived from tetraphenylethane, boranes and iniferter substances comprising at least one thiuram disulphide group, (B) an ethylenically unsaturated substance capable of adding a free radical to its ethylenic double bond, (C) molecular iodine, which comprises the steps according to which at least a fraction of (A), at least a fraction of (B) and at least a fraction of (C) are introduced into a reactor, and then the contents of the reactor are caused to react, while introducing therein the possible remainder of (A), the possible remainder of (B) and the possible remainder of (C), until a moment is reached when the content of the reactor is a mixture comprising one or more substances (S). Iodinated organic substances for whose preparation the abovementioned process is particularly well suited.
US07741523B2 Method for oxidizing saturated cyclic hydrocarbons by oxygen
The present invention relates to a continuous method for oxidizing saturated cyclic hydrocarbons by oxygen to obtain a mixture of hydroperoxides, alcohols and ketones. It relates more particularly to a method for oxidizing cyclohexane in a column forming a bubble reactor, for the formation of cyclohexyl hydroperoxide, cyclohexanol and cyclohexanone. According to the invention, the column may be supplied with oxygen-enriched air, while meeting the maximum oxygen concentration requirements in the headspace of the reactor to avoid any risk of explosion.
US07741522B2 Direct amination of hydrocarbons
A process for aminating hydrocarbons with ammonia in the presence of catalyst (i) which catalyzes the amination, which comprises supplying oxidizing agent to the reaction mixture and reacting the oxidizing agent with hydrogen which is formed in the amination in the presence of a catalyst (ii) which catalyzes this reaction with hydrogen.
US07741519B2 Bis-aryl sulfonamides
Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
US07741517B2 Process for the production of acetic acid
A process for the production of acetic acid by carbonylating methanol and/or a reactive derivative thereof with carbon monoxide in the presence of an iridium promoted carbonylation catalyst wherein the promoters are ruthenium and at least one of niobium and tantalum.
US07741515B2 Optimized liquid-phase oxidation
Disclosed is an optimized process and apparatus for more efficiently and economically carrying out the liquid-phase oxidation of an oxidizable compound. Such liquid-phase oxidation is carried out in a bubble column reactor that provides for a highly efficient reaction at relatively low temperatures. When the oxidized compound is para-xylene and the product from the oxidation reaction is crude terephthalic acid (CTA), such CTA product can be purified and separated by more economical techniques than could be employed if the CTA were formed by a conventional high-temperature oxidation process.
US07741509B2 Conversion of terephthalic acid to Di-n-butyl terephthalate
Disclosed is a process for the preparation of di-n-butyl terephthalate by the esterification of terephthalic acid with n-butanol in the presence of a strong acid while employing a fractionating column.
US07741508B2 Single step green process for the preparation of substituted cinnamic esters with trans-selectivity
The invention provides a green process for direct oxidation of a large number of substituted or unsubstituted cinnamaldehydes or cinnamyl alcohols into the corresponding alkyl or aryl cinnamates in one step. The process of the present invention is a convenient and efficient green process for the preparation of various aryl or alkyl cinnamates under conventional, microwave and ultrasound directly from cinnamaldehydes or cinnamyl alcohols in the presence of an oxidizing agent, catalyst and an alcohol, with or without an organic solvent. These esters are immensely important compounds in flavor, perfumery and pharmaceutical industries. There are several prior arts available for the preparation of cinnamic esters, but all of them suffer from deficiencies such as use of expensive reagents and catalysts, harsh reaction conditions, use of toxic chemicals and others. In contrast, the present methodology is extremely simple and involves reaction of the substrate with an oxidizing agent mixed with a homogeneous or heterogeneous catalyst and an alcohol with or without organic solvent by stirring at room temperature or refluxing or under microwave or ultrasound irradiation to get the requisite products.
US07741507B2 Process for preparing Valsartan
The invention relates to novel compound of formula (IV), which is an organic acid salt of N-[(2′-cyanobiphenyl-4-yl)methyl]-(L)-valine ester. This compound is an useful intermediate for process of preparation of Valsartan of formula (I), chemically known as (S)—N-(1-Carboxy-2-methylprop-1-yl)-N-pentanoyl-N-[2′-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]amine. This invention also relates to a process for preparing Valsartan using novel intermediate of formula (IV).
US07741506B2 Probe for measuring phytase activity
A myo-inositol derivative: R1, R2, R3 and R4 are identical, being selected from PO3H2, PO3Na2, PO3K2, PO3Li2, PO3Ca, PO3Mg, PO3(NH4)2, PO3(RNH3)2, PO3(R2NH2)2, PO3(R4N)2, PO(OR)2, H, COZ and BHPP, where R is benzyl or alkyl of 1 to 6 carbon atoms and Z is an alkyl or arylalky group providing a cleavable protecting group; R5 is one of H, benzyl, 4-methoxybenzyl, COZ, PO3H2, PO3Na2, PO3K2, PO3Li2, PO3Ca, PO3Mg, PO3(NH4)2, PO3(RNH3)2, PO3(R2NH2)2, PO3(R4N)2, PO(OR)2, and BHPP, where R is benzyl or alkyl of 1 to 6 carbon atoms and Z is an alkyl or arylalky group providing a cleavable protecting group; X is one of CH2, CH2CH2O, and CH2CH2CH2O; n is an integer from 1 to 8; L1 is a single bond or CH2; L2 is one of a single bond, CONH, CH2CONH, CH2CH2CONH, CH2CH2NHCO, CH2CH2NHCONH, CH2CH2NHCSNH, CH2CH2NHSO2, CH2CH2CH2NHCO, CH2CH2CH2NHCONH, CH2CH2CH2NHCSNH, CH2CH2CH2NHSO2, NHCO, NHCONH, NHCSNH, OCONH, CH2, CH2CH2, CH2CH2O, CH2CH2S, CH2CH2NH, CH2CH2CH2, CH2CH2CH2O, CH2CH2CH2S, CH2CH2CH2NH, and NH—SO2; and R6 is a UV-visible chromophore, a UV-chromophore, a fluorescent moiety, or a radiolabeled moiety.
US07741504B2 Method for preparing an ω-haloalkyl dialkylhalosilane
The present invention relates to a method for preparing an omega-haloalkyl dialkylhalosilane by means of a hydrosilylation reaction in the presence of a catalytically effective amount of a hydrosilylation catalyst containing a platinum group metal. The catalytic metal is recovered by (i) subjecting the distillation residue to controlled hydrolysis to release the gaseous H-Hal haloacid, and providing an aqueous medium containing the catalytic metal with a low hydrolysable halide content Si-Hal=2%, expressed by weight of Hal, then (2i) recovering the platinum group catalytic metal from said aqueous medium by means of one of the conventional techniques specific to catalyst manufacturers that do not use a solid adsorbent and operate in ordinary facilities that do not have to be acid-resistant.
US07741502B2 Method of manufacturing alcohol esters from triglycerides and alcohols using heterogeneous catalysts based on phosphate or an organophosphorous compound of a group 4 metal
A method of manufacturing a composition of alcohol esters of linear monocarboxylic acids with 6 to 26 carbon atoms from a vegetable or animal oil, neutral or acid, virgin or recycled, with monoalcohols having 1 to 18 carbon atoms, in the presence of a phosphate type catalyst or of an organophosphorous compound of a metal selected from the group made up of zirconium, hafnium and titanium, allows to directly produce, in one or more stages, an ester that can be used as fuel and a pure glycerin.
US07741499B2 Catalyst composition
There is provided a catalyst carrier comprising a refractory inorganic material having a sodium solubilization rate no greater than 5 ppmw/5 minutes. There is further a catalyst comprising a refractory inorganic material carrier having a sodium solubilization rate no greater than 5 ppmw/5 minutes; and one or more catalytically reactive metals deposited on said carrier. There is also provided a catalyst suitable for the vapor phase production of alkylene oxide from olefins and oxygen comprising an alumina-based carrier having a sodium solubilization rate no greater than 5 ppmw/5 minutes; and catalytically reactive silver deposited on said carrier.
US07741495B2 Indoline-sulfonamides compounds
A series of indoline-sulfonamide compounds is disclosed. The formula of indoline-sulfonamide compounds is shown as formula (I). In formula (I), R1 is H or halogen; R2 is Ar, Ar—C(O)—, Ar—CH2—, Ar—SO2—, Ar—O—C(O), or R″—C(O)—, and Ar is a substituted or unsubstituted C5-C20 aryl, cyclyl, heterocyclyl, or heteroaryl, R′ and R″ independently is C1-C10 alkyl, or C1-C10 alkoxyl; and R3 is C5-C15 aryl or C1-C10 alkyl. The indoline-sulfonamide compounds disclosed in the present invention are characterized in inhibiting tubulin polymerization, and treating cancers and other tubulin polymerization-related disorders with a suitable pharmaceutical acceptable carrier.
US07741493B2 Heterocyclic compounds as P2X7 ion channel blockers
The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.
US07741490B2 Intermediates for the preparation of pramipexole
Intermediates useful for the preparation of pramipexole and the use thereof in such synthesis.
US07741488B2 Tetrahydropyridothiophenes as antiproliferative agents for the treatment of cancer
Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
US07741487B2 Method for producing quaterrylene-3,4:13, 14-tetracarboxy diimides by direct synthesis
A process for preparing quaterrylene-3,4:13,14-tetracarboximides of the general formula I in which R, R′ are each independently hydrogen or optionally substituted C1-C30-alkyl, C5-C8-cycloalkyl or aryl or hetaryl; which comprises reacting a perylene-3,4-dicarboximide of the general formula IIa in the presence of a base-stable, high-boiling, organic solvent and of an alkali metal base or alkaline earth metal base, with a perylene-3,4-dicarboximide of the general formula IIb in which X is hydrogen, bromine or chlorine.
US07741483B2 Process for making substituted pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of phosphodiesterase 5
The invention relates to the compounds of formula I, their preparation and the pharmaceutical compositions containing the compounds. The invention also relates to the use of the compounds of formula I in preparing medicines, which can treat sexual dysfunction of animals including human (male and female), especially erectile dysfunction of male and the diseases in which the function of phospholipase 5 (cGMP PDE5) is involved.
US07741482B2 Reference standard for characterization of rosuvastatin
Provided are rosuvastatin degradation products and their use as a reference standard (including reference marker) for analysis of rosuvastatin.
US07741478B2 Salts in the preparation of cephalosporin antibiotics
Compounds of general formula (II), wherein R1 represents R4 represents hydrogen or —CHO group, R5 represents hydrogen or trityl, R2 represents hydrogen or methoxy group, R3 represents —CH═CH2 or and M represents a dialkyl or dicycloalkyl ethylenediamine group selected from N,N′-diisobutylethylenediamine, N,N′-dicyclohexylethylenediamine, and N,N′-dicyclopentylethylenediamine, are useful in a process to make cephalosporin antibiotics of formula (I) wherein R represents hydrogen or pharmaceutically acceptable esters or alkali metals salts.
US07741473B2 Process for the preparation of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][1,3]dioxoles
The present invention is directed to a processes for the synthesis of trans isomer of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][1,3]dioxoles (Formula I). The process comprises the steps of: (a) obtaining a compound of Formula II, which is a mixture of cis and trans-diastereomers, and (b) chemically decomposing the compound of Formula II in a solution comprising a solvent and an acid that is a hydrogen donor or an electron pair acceptor, whereby the cis diastereomer is decomposed and the compound of Formula I is obtained. The compounds prepared by the present invention are useful in treating diseases or conditions associated with platelet aggregation and/or platelet activation.
US07741471B2 Reagents for the improved synthesis of isoguanosine containing oligonucleotides
The present invention provides the combination of the O-2 diphenylcarbamoyl (“DPC”) and N-6 dimethylaminomethylidene (“DMF”) protecting groups for isoguanosine nucleosides that can be utilized in oligonucleotide synthesis.
US07741467B2 Non-fluorescent energy transfer
The present invention relates generally to the transfer of non-fluorescent energy between donor and acceptor moieties. In certain embodiments, the invention provides biomolecules that include substantially non-fluorescent donor moieties. Processes involving these donor moieties typically entail reduced background fluorescence relative to applications that involve conventional fluorescent donor moieties. In addition to reaction mixtures and methods that include the use of these biomolecules, the invention also provides related kits and systems.
US07741464B2 Compositions and methods of using CRMP-1 and its fragments for treating cancer
The present invention discloses a method for treating cancer by using hCRMP1 and/or active fragments thereof, as well as the active fragments of hCRMP1 that are capable of inhibiting cell proliferation, invasive activity, and metastasis of cancer. The method can also be used prior to, or in combination with, the administration a chemotherapy agent. A vector capable of expressing an hCRMP1, a variant of hCRMP1, a fragment of hCRMP1 or a variant of a fragment of hCRMP1 is also disclosed.
US07741459B2 Nucleic acid anchoring system comprising covalent linkage of an oligonucleotide to a solid support
The anchoring system generally comprises a solid support and a chemical linking moiety useful for ether formation with another chemical moiety on a nucleic acid molecule. The present invention further contemplates methods for anchoring a nucleic acid molecule to a solid support via a covalent linkage. The anchoring system of the present invention is useful inter alia in construction of nucleic acid arrays, to purify nucleic acid molecules and to anchor nucleic acid molecules so that they can be used as templates for in vitro transcription and/or translation experiments and to participate in amplification reactions. The present invention is particularly adaptable for use with microspheres and the preparation of microsphere suspension arrays and optical fiber arrays. The anchoring system permits the generation of an anchored oligonucleotide for use as a universal nucleic acid conjugation substrate for any nucleic acid molecule or population of nucleic acid molecules. The present invention further provides a kit useful for anchoring nucleic acid molecules or comprising nucleic acid molecules already anchored to a solid support.
US07741456B2 Polyketides and antibiotics produced by combinatorial techniques
Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
US07741453B2 Long lasting fusion peptide inhibitors for HIV infection
The present invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.
US07741447B2 Antibody against tumor specific antigen as target
The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
US07741445B2 Breast cancer resistance protein (BCRP) antibodies
The Breast Cancer Resistance Protein is described, as well as the cDNA encoding said protein. This protein has been found to confer resistance to cancer chemotherapeutic drugs.
US07741444B2 Neoplasm specific antibodies and uses thereof
The present invention features polypeptides, such as antibodies, and their use in the treatment and diagnosis of neoplasms.
US07741442B2 Antibody composition exhibiting increased cellular cytotoxicity due to glycosylation
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
US07741441B2 Method for producing type IV collagen
An object of the invention is to provide type IV collagen without contamination by other proteins and without degradation or denaturation. The present invention provides a type IV collagen which is derived and extracted from lens capsules without the use of an enzyme and has a minimum molecular weight of 160 to 180 kDa measured by SDS-PAGE under reduced conditions.
US07741438B2 Methods and compositions involving endopeptidases PepO2 and PepO3
The present invention concerns the methods and compositions involving endopeptidase enzymes, especially PepO2 and PepO3 from L. helveticus, and their use in reducing bitterness by cleaving bitter peptides. In particular embodiments of the invention, these methods and compositions apply to the cheesemaking process. The invention also concerns the use of PepO2 and/or PepO3 polypeptides in the treatment or prevention of celiac sprue or as a food additive.
US07741437B2 P. ariasi polypeptides, p. perniciosus polypeptides and methods of use
Substantially purified salivary P. ariasi and P. perniciosus polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the P. ariasi and P. perniciosus polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating or preventing Leishmaniasis are disclosed.
US07741433B2 Diagnostic markers, especially for in vivo imaging and assays and methods of use thereof
Novel splice variants as diagnostic markers, preferably membrane-bound. The novel variants according to the present invention may optionally be used for diagnosis of Marker-detectable disease as described herein, optionally through immunohistochemistry.
US07741429B2 Process for preparing stable photoresist compositions
A method of making a stable photoresist solution containing a polymer from a solution of a polymer containing trace metals, said method comprising the steps of: (a) providing a polymer solution containing a polymer, a first solvent and trace metals; (b) passing said polymer solution through an acidic cation ion exchange material to remove said trace metals therefrom and thereby forming a polymer solution containing free acid radicals; (c) precipitating said polymer from said polymer solution of step b by contacting with a second solvent wherein the polymer is substantially insoluble therein; (d) filtering said solution and said second solvent to thereby form a solid polymer cake; (e) contacting said cake from step d with sufficient quantities of additional said second solvent in order to remove free acid radicals therefrom; (f) adding a compatible photoresist solvent to said solid polymer cake from step e and mixing the two in order to dissolve said polymer in said photoresist solvent and thereby forming a photoresist solution; and (g) removing any residual first and second solvents from said photoresist solution containing said polymer to form a stable photoresist solution.
US07741427B2 Barrier membrane
The present invention relates to a cell-occlusive membrane, obtainable by reaction of at least two precursors in the presence of water. The first precursor A comprises a core and n chains each having a conjugated unsaturated group or a conjugated unsaturated bond, and the second precursor B comprises a core and m chains each having a thiol group, wherein m is greater than or equal to 2, n is greater than or equal to 2, and m+n is greater than or equal 5. The reaction forms a three dimensional network with crosslinking-points. The adjacent crosslinking-points are connected by a chain having less than 600 atoms.
US07741426B2 Method for production of fluorinated phenylenediamine
A method for the production of a fluorinated phenylenediamine is provided which comprises steps of reacting a diamide represented by the following formula with NaOCl at a molar ratio of the NaOCl to the diamide in the range of 2.0-6.0 and NaOH at a molar ratio of the NaOH to the diamide in the range of 1.8-6.0 is provided. According to this invention, the fluorinated phenylenediamine can be produced conveniently in a high yield.
US07741425B2 Reactive polyurethane-hot melt adhesive having a low isocyanate-monomer content
The invention relates to relates to moisture-hardened hot melt adhesive which contains at least one polyurethane polymer of formula (I) which comprises aldimine groups and which is solid at room temperature, in addition to at least one polyurethane polymer P which comprises isocyanate groups, if q in formula (I) represents zero, or if X in formula (I) represents N—R8 with R8 as a substituent of formula (III). The compositions are characterised in that contain visibly less isocyanate monomers and are therefor particularly advantageous from a work-hygiene point of view.
US07741424B2 Phosphoric ester of cellulose derivative and metal adsorbent comprising the same
The present invention is directed to a phosphoric ester of 2,3-dihydroxypropyl cellulose or 3-(2,3-dihydroxypropoxy)-2-hydroxypropyl cellulose, the cellulose having optionally undergone partial carbamidation, and to a metal absorbent employing the ester, and to a metal-absorbing apparatus employing the metal adsorbent.The cellulose derivative phosphoric ester serves as a metal adsorbent which exhibits high metal adsorption performance and metal adsorption rate per unit weight; has high mechanical strength; effectively soften water or a similar liquid; removes heavy metals from wastewater or a similar liquid at remarkably high efficiency; has excellent processability and can be formed into a variety of shapes and thus is applicable within a wide range; and can readily be reutilized.
US07741422B2 Process for making vinyl fluoride interpolymers and dispersions
Interpolymers of 1-99 mol % vinyl fluoride and 99-1 mol % of at least one highly fluorinated monomer such as tetrafluoroethylene are disclosed. The interpolymers are characterized by the presence of ionic end groups and are prepared by polymerizing VF and fluorinated monomer in water with water-soluble free-radical initiators such as azoamidine initiators or persulfate initiators at temperatures within the range of 60 to 100° C. and reactor pressures within the range of 1 to 12 MPa (145 to 1760 psi). The invention further provides for protective self-supporting films and coatings formed from nonaqueous dispersions of the interpolymers, both for use on the surfaces of substrates including metal, plastic, ceramic, glass, concrete, fabric and wood.
US07741419B2 Process for producing olefin polymers
A process for producing an olefin polymer is provided, in which ethylene and at least one kind or more of monomers selected from α-olefins are polymerized by a high temperature solution polymerization in a temperature range between 120 and 300° C., in the presence of an olefin polymerization catalyst composed of a bridged metallocene compound represented by general formula [I] described below and at least one kind or more compounds (B) selected from (b-1) an organoaluminum oxy-compound, (b-2) a compound capable of forming an ion pair in a reaction with the bridged metallocene compound mentioned above, and (b-3) an organoaluminum compound. According to the high temperature solution polymerization of the present invention, it has become possible to obtain a polymer having a high molecular weight with high polymerization activity that was so far unattainable, and when the polymer is a copolymer, it is a process for producing a high molecular weight olefin polymer with a large comonomer content, a narrow composition distribution, and a narrow molecular weight distribution.
US07741417B2 Preparation of polymerization catalyst activators utilizing indole-modified silica supports
A process for polymerizing propylene is provided. The process comprises contacting propylene and optionally one or more monomers with a catalyst system comprising a bis-indenyl Group 4 metallocene compound supported on silica, the silica treated with one or more organoaluminum compounds and one or more heterocyclic compounds, under slurry conditions in the presence of hydrogen at a temperature of about 50° C. to about 160° C. and a pressure of from about 3 MPa to about 5 MPa to provide a catalyst activity of greater than 30,000 pounds of product per pound of catalyst; and then recovering isotactic polypropylene having a melt flow rate of 20 dg/min or less as measured according to ASTM D-1238 at 230° C. and 2.16 kg.
US07741415B2 Process for producing low density polyethylene compositions and polymers produced therefrom
The present invention relates to an ethylene homo or copolymer characterized as having long chain branching, and having a molecular weight distribution, Mw/Mn, and a GPC-LALLS CDF, which satisfies the following relationship: y≧0.0663x−0.015, wherein y=GPC-LALLS CDF and x=Mw/Mn measured by conventional GPC, a line drawn from where the LS chromatogram intersects with molecular weight 350,000 and molecular weight 1,150,000 has a positive slope, preferably with a melt index between 0.15 and 2000 g/10 minutes and having long chain branching. In addition, the invention relates to a free radical initiation polymerization process for the preparation of ethylene polymers or copolymers, comprising reacting ethylene and optionally one or more comonomers at a high pressure, conveniently between 13,000 psig and 100,000 psig, and at reactor temperatures of 115° C. to 400° C., preferably 125-400° C., more preferably 140-350° C., especially 165-320° C., in a reactor system comprising at least one tubular, and at least one autoclave reactor, wherein the monomer(s) feed into the reactors is divided into multiple monomer feed streams, and wherein at least one feed stream into the tubular reactor consists essentially of unreacted monomer.
US07741413B2 Curable compositions having improved adhesion performance
The present invention relates to adhesion-improved, curable compositions comprising a cyclic ether, a cyclic thiocarbonate, an amine and a carboxylic acid. A method of making such compositions and their use in adhesives, sealants and coatings are also provided.
US07741412B2 Curable organopolysiloxane composition
A curable organopolysiloxane composition is provided, which includes (A) an organopolysiloxane containing at least one silicon atom-bonded alkenyl group within each molecule, (B) an organohydrogenpolysiloxane, which contains, within each molecule, at least one silicon atom-bonded hydrogen atom at a molecular chain terminal, and at least two silicon atom-bonded hydrogen atoms at non-terminal positions within the molecular chain, and which satisfies the formula shown below: 0<α/β0.25 (wherein, α represents the number of silicon atom-bonded hydrogen atoms at non-terminal positions within the molecular chain, and β represents the total number of silicon atoms within the component (B)), in sufficient quantity to provide from 0.1 to 5 silicon atom-bonded hydrogen atoms per silicon atom-bonded alkenyl group within the component (A), and (C) a platinum-based catalyst. The composition can be cured even at low temperatures, generates a cured product that suffers no surface wrinkling, and displays excellent storage characteristics.
US07741409B2 Cure system composition and a method for curing chlorinated elastomer compositions
The instant invention is an improved cure system composition and a method for curing chlorinated elastomer compositions. The cure system composition includes a polymercapto crosslinking agent; an inorganic base; and an onium salt. The onium salt has a formula selected from the group consisting of formula (I) and formula (II); wherein Z is a nitrogen or phosphorous atom, R1 to R4 are independently alkyl or aryl groups containing between 2 and 8 carbon atoms, and the total number of carbon atoms on R1-R4 is between 10 and 14; wherein R5 and R6 are alkyl groups containing between 1 and 8 carbon atoms, and the total number of carbon atoms on R5-R6 being between 5 and 9; and wherein X is an anion. The method for curing a chlorinated elastomer composition according to instant invention includes the following steps: (1) providing a chlorinated elastomer composition; (2) providing a cure system composition as described above; (3) contacting said chlorinated elastomer composition with said cure system composition; and (4) thereby curing said chlorinated elastomer composition.
US07741408B2 Low gloss thermoformable flooring structure
A novel flooring composition was developed based on a blend comprising: a) an elastomer; b) a random propylene/alpha-olefin copolymer; c) a cross linking agent; and optionally d) a melt strength enhancing polymer. This composition achieves a unique balance of properties, exhibiting often-conflicting performance requirements. These include low gloss and excellent pattern duplication in embossing, low modulus, minimal odor, excellent grain acceptance and abrasion resistance, while remaining thermoformable and maintaining minimal shift in viscosity during recycle.
US07741406B2 Phenol-formaldehyde resin having low concentration of tetradimer
A phenol-formaldehyde resin, having a low concentration of tetradimer, making the resin suitable for preparing a binder composition for making non-woven fiber products, such as fiberglass insulation, prepared by reacting phenol and formaldehyde in the presence of a sulfite source.
US07741404B2 Polyurethane dispersants
The present invention provides a non-aqueous composition containing a particulate solid, an organic medium and a polyurethane dispersant having an essentially linear backbone and laterally attached solvent-solubilising side chains of a polyester, a polyether, a polyacrylate or a polyolefin including mixtures of such side chains.
US07741399B2 Rubber composition and tire using the same
Disclosed is a rubber composition having excellent low loss characteristics and capable of imparting a tire with wear resistance and fracture resistance. The rubber composition is obtained by blending a carbon black, which has a toluene coloring transmittance of not less than 90% while satisfying the following relation between the hydrogen emission rate (mass %) and the cetyltrimethylammonium bromide adsorption specific surface area (CTAB) (m2/g): the hydrogen emission rate >0.260−6.25×10−4×CTAB, into a modified natural rubber which is obtained by adding a polar group-containing monomer into a natural rubber latex for graft-polymerizing the polar group-containing monomer to a natural rubber molecule in the natural rubber latex, and then solidifying and drying the resulting product.
US07741397B2 Filled polymer compositions made from interpolymers of ethylene/α-olefins and uses thereof
A filled polymer composition comprises (i) an ethylene/α-olefin interpolymer, and (ii) a filler. The ethylene/α-olefin interpolymer is a block copolymer having at least a hard block and at least a soft block. The soft block comprises a higher amount of comonomers than the hard block. The block interpolymer has a number of unique characteristics disclosed here. The filled polymer compositions provided herein, in certain embodiments, have relatively higher heat resistance and improved noise, vibration and harshness properties and can be used in automotive floorings, roofings, wire and cable coating applications.
US07741393B2 Organic silicon-based compound and method of producing the same
Provided are an organic silicon compound of the following formula (I): (wherein, R1 to R20 represent each independently alkyl, alkoxy, aryloxy, cycloalkyl, alkylcycloalkyl, aryl, dialkylamino or the like, and the aryloxy and aryl may be substituted with a substituent selected from the group consisting of alkyl, alkoxy and alkoxyalkyl.) which can be used for suppression of coloration and thermal deterioration of an organic material in molding, and an organic material composition containing the organic silicon compound and a method of producing the organic silicon compound.
US07741387B2 Roadway repair and maintenance
A flowable material for pavement repair and maintenance comprises rounded sand coated with a polymeric surfactant to be non absorbent of water in the presence of a polymer mix which allows time for easy placement of the mix into damaged pavement. The polymeric surfactant coating creates a strong affinity between the sand and the polymer mix. The materials are chosen preferably to cause an isoviscous reaction to occur. This type of reaction is characterized by a setting phase which stabilizes the repair before a rapid change in viscosity occurs and may be further enabled by an excess of polymer to increase flowability. An excess of polymer insures that sufficient binder remains at the upper portions of the repair to provide flexible and waterproof structure while excess fluid components settle to the bottom of the repair before setting occurs to seal the surrounding pavement. The slow buildup of viscosity allows the sand to settle so that the mix becomes self-compacting.
US07741386B2 Water-based ink for inkjet printing
A water dispersion for inkjet printing which contains polymer particles containing a colorant. The polymer constituting the polymer particles is produced by the copolymerization of a monomer mixture in the presence of a-methylstyrene dimer. The water dispersion for inkjet printing and a water-based ink for inkjet printing containing the water dispersion exhibit excellent jetting properties and a high optical density.
US07741385B2 Ozone stable ink-jet inks
An ink set includes an ozone stable cyan ink, and an ozone stable magenta ink. According to this exemplary embodiment, the ozone stable magenta ink includes an ozone stable magenta dye and a liquid vehicle including a fluorocarbon surfactant formed at least in part from a polymer comprising at least one Formula 1: Where R1=OH and R2=O(CH2)m-(CF2)nCF3 with m=1-3 and n=0-3.
US07741384B2 Encapsulation of pigment particles by polymerization
A method of preparing an ink includes homogenizing a dispersion to coat pigment particles in the dispersion with a monomer. An ink for use in a printing device includes pigment particles encapsulated in a polymerized monomer, where the monomer has a polarity that is higher than a polarity of a surface of the pigment particles.
US07741381B2 Curable composition
A curable composition comprising: (A) 100 parts by mass of a monomer component which comprises a radically polymerizable monomer and has a water absorbing capacity of not larger than 20% by weight; (B) 0.5 to 10 parts by mass of water; (C) 0.1 to 20 parts by mass of a surfactant; and (D) an effective amount of a radical polymerization initiator. The curable composition is cured by polymerization in a state where a water layer is formed on the surfaces of the cured body that is being formed, effectively suppressing the hindrance of polymerization caused by oxygen and decreasing the formation of unpolymerized product on the surfaces of the cured body. The curable composition is particularly useful as a dental restorative which involves difficulty when it is to be polymerized while shutting off oxygen.
US07741380B2 Ink composition, ink jet recording method, method for producing planographic printing plate and planographic printing plate
The invention provides (1) an ink composition including a polymerization initiator and at least one compound selected from the group consisting of (meth)acrylic acid and monofunctional (meth)acrylic acid esters and amides each having a carboxy group in the molecule, (2) an ink composition including a polymerization initiator, at least one compound selected from the group consisting of (meth)acrylic acid and monofunctional (meth)acrylic acid esters and amides each having a carboxy group in the molecule, and a monofunctional (meth)acrylic acid ester or amide having an alkylene oxide repeating unit in the molecule, and (3) an ink composition including a polymerization initiator and a monofunctional (meth)acrylic acid ester or amide having a basic group in the molecule; and an ink jet recording method, a method for producing a planographic printing plate and a planographic printing plate produced by the method for producing a planographic printing plate using the above-mentioned ink compositions.
US07741378B2 Porous monodispersed particles and method for production thereof, and use thereof
To provide porous monodispersed particles obtained by preparing, as seed particles, poly(methyl methacrylate) particles or acrylic resin particles comprising 70% by mass or more of methyl methacrylate as a copolymerization component, swelling the seed particles 20 to 80 times the size of the original seed particles by mass using a swelling solution comprising an oil-soluble polymerization initiator and a monomer mixture containing 70% by mass or more of methyl methacrylate and 3 to 8% by mass of divinylbenzene, and polymerizing the monomers. The particles are porous particles with a diameter of the order of micrometers and a narrow particle-size distribution and are monodispersed. Colored monodispersed particles obtained by agglomerating a pigment in the porous monodispersed particles are monodispersed and spherical, and contain a large amount of pigment therein.
US07741372B2 Guanylhydrazones useful for treating diseases associated with T cell activation
There is disclosed a method for treating diseases and disorders involving T cell activation and HIV-infection using the p38 mitogen activated protein kinase (MAPK) signaling pathway as a target for intervention. There is further disclosed a use for guanylhydrazone-substituted compounds to treat diseases and disorders related to T cell activation and HIV-infection.
US07741371B2 Selective androgen receptor modulators and methods of use thereof
This invention provides a class of androgen receptor targeting agents (ARTA). The compounds are selective androgen receptor modulators (SARM) useful for, inter-alia, suppressing spermatogenesis, treating a subject having a hormone related condition, treating a subject suffering from prostate cancer, delaying the progression of prostate cancer, preventing the recurrence of prostate cancer, and treating the recurrence of prostate cancer.
US07741369B2 Lipoxin compounds and their use in treating cell proliferative disorders
Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed.
US07741368B2 Approach to antimicrobial host defense with molecular shields with EPA and DHA analogs
Methods to cause tissue, such as mucosal cells, to express increased amounts of bactericidal permeability increasing protein (BPI) are described. Various BPI inducing agents include icosapentanoic acid (EPA) analogs and docosahexaenoic acid (DHA) analogs.
US07741367B2 Method of using abscisic acid to treat diseases and disorders
The present invention provides compositions and methods for treating and/or preventing diseases and disorders associated with expression of PPAR γ and/or infiltration of macrophages into skeletal muscle tissue and/or white adipose tissue. The method treats such diseases and disorders with abscisic acid (ABA). Exemplary diseases and disorders include diabetes, including type 2 diabetes, prediabetes, glucose intolerance insulin resistance, and diseases and disorders involving the immune system, such as inflammation, including obesity-related inflammation, inflammatory bowel disease, type 1 diabetes, multiple sclerosis, allergies, asthma, cardiovascular disease, and arthritis.
US07741365B2 Peripheral cannabinoid receptor (CB2) selective ligands
Novel polycyclic cannabinoid analogs are presented which have preferentially high affinities for the cannabinoid CB2 receptor sites.
US07741364B2 Pyrrole derivatives and their methods of use
The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
US07741360B2 Bi-aryl or aryl-heteroaryl substituted indoles
The present invention relates to substituted indoles of Formula (I) useful as pharmaceutical compounds for treating respiratory disorders.
US07741355B2 Small-molecule modulators of TRP-p8 activity
Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.
US07741350B1 Bicyclic pyrazolo-heterocycles
The present invention provides substituted pyrazolo-heterocycles having the general structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
US07741349B2 Imidazo[2, 1-b]-1,3,4-thiadiazole sulfonamides
This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems. Formula I:
US07741348B2 Bisheterocycle tandem compounds useful as antiviral agents, the uses thereof and the compositions comprising such compounds
The present invention provides small molecule compounds of bisheterocycle in tandem having the structural formula of P1-P2, and the use thereof as well as a composition containing the compounds, each of P1 and P2 is an unsaturated 5-member heterocyclic ring having one or two heteroatoms. This compound may effectively inhibit the replication of influenza virus, the DNA replication of hepatitis B virus (HBV), and the formation of HBsAg and HBeAg. These compounds can be used for the preparation of a medicament for viral diseases, and may overcome the limitations of the known nucleosides drugs, including cytotoxicity, the requirement of other drugs having different structures for against the drug-resistant virus variants induced by long-term therapy. The structure of the compounds according to the invention is relatively simple and easy to be prepared.
US07741347B2 Hepatitis C virus inhibitors
The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
US07741345B2 AZA-peptide protease inhibitors
The invention is related to compounds of Formula I: or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
US07741343B2 6H-oxazolo[4,5 e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands
Compounds of the formula I in which R1, R2, R3 and R4 are as defined in Claim 1, are ligands of the nicotinic acetylcholine receptor and/or serotonergic ligands and are suitable for the prophylaxis or treatment of psychoses, schizophrenia, depression, anxiety states, dementia, in particular Alzheimer's disease and Lewy bodies dementia, neurodegenerative disorders, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, Tourette's syndrome, learning and memory restrictions, bulimia, anorexia nervosa or other eating disorders, compulsive behavior, premenstrual syndrome, age-induced memory impairment, amelioration of withdrawal symptoms in nicotine dependence, strokes or brain damage by toxic compounds, and for the treatment of disorders which are characterized by an excess of circulating serotonin or by serotonergic hyperactivity.
US07741337B2 Azonafide derivatives, methods for their production and pharmaceutical compositions therefrom
The present invention is directed to azonafide derivatives obtained by reacting azonafide with aldehydes, acyl halides, thioacyl halides, monoisocyanates, isothiocyanates, sulfonyl halides, monohalogenoalkanes, monohalogenoalkenes or monohalogenoalkynes, and are useful as active ingredients of pharmaceutical compositions for the prevention and treatment of cell proliferative disorders, in particular several forms of cancer.
US07741335B2 Use of tyrosine kinase inhibitors for treating inflammatory diseases
The present invention relates to a method for treating inflammatory diseases such as rheumatoid arthritis (RA), comprising administering a tyrosine kinase inhibitor to a human in need of such treatment, more particularly a non-toxic, selective and potent c-kit inhibitor. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.
US07741334B2 Low dose therapy for treating viral infections
A method of treating viral infections, particularly Hepatitis B (HBV) and Human Immunodeficiency Virus (HIV), by administering a low dose of Elvucitabine to a patient suffering viral infection is provided herein. The Elvucitabine dosages provided herein for effective anti-viral therapy are approximately 10-fold less than the effective dosages of currently marketed reverse transcriptase inhibitors. The Elvucitabine dosage may be given BID, daily, once every 48 hours, or once weekly. Also provided herein are packaged pharmaceutical formulations comprising Elvucitabine and instructions for treating a viral infection by administering a low BID, daily, once/48 hour, or weekly dosage of Elvucitabine. The low dose Elvucitabine formulations provided herein have the additional benefit of improving patient compliance with anti-viral therapy.
US07741332B2 Fused ring heterocycles as potassium channel modulators
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.
US07741330B1 Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.
US07741329B2 N-aroyl cyclic amines
Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.
US07741328B2 Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
US07741319B2 11-hydroxy-5h-pyrrolo[2,1-c][1,4] benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines
The present inventors have developed a key intermediate for the production of C2 substituted PBDs, which has a leaving group at the C2 position, a carbamate protecting group at the N10 position and a protected hydroxy group at the C11 position. In a first aspect, the present invention comprises a compound with a the formula (I), wherein: R10 is a carbamate-based nitrogen protecting group; R11 is an oxygen protecting group; and R2 is a labile leaving group. In a further aspect, the present invention comprises a method of synthesising a compound of formula (III), or a solvate thereof, from a compound of formula (I) as defined in the first aspect, R16 is either O—R11, wherein R11 is as defined in the first aspect, or OH, or R10 and R16 together form a double bond between N10 and C11; and R15 is R. The other substituents are defined in the claims. Further aspects of the present invention relate to compounds of formula (III) (including solvates thereof when R10 and R16 form a double bond between N10 and C11, and pharmaceutical salts thereof), pharmaceutical compositions comprising these, and their use in the manufacture of a medicament for the treatment of a proliferative disease.
US07741318B2 Pyrazolo [1,5-A]pyrimidine adenosine A2a receptor antagonists
Compounds having the structural formula I are disclosed, wherein A is alkylene, or optionally substituted arylene, cycloalkylene or heteroaryldiyl; X is —C(O)— or —S(O)2—; R1 is alkyl or cycloalkyl; R2 is hydrogen, halo or —CN; R3 is hydrogen or alkyl; R4 is hydrogen, alkyl, alkoxy, hydroxyalkyl, aminoalkyl-, cycloalkyl, heterocycloalkyl, heterocycloalkyl substituted by alkyl, optionally substituted arylalkyl or optionally substituted heteroarylalkyl; or R3 and R4, form an optionally substituted 5-7 membered ring, said ring optionally comprising an additional heteroatom ring member; R7 is alkyl, optionally substituted phenyl, optionally substituted heteroaryl, cycloalkyl, halo, morpholinyl, optionally substituted piperazinyl, or optionally substituted azacycloalkyl. Also disclosed is the use of the compounds in the treatment of Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, pharmaceutical compositions comprising them and kits comprising the components of the combinations.
US07741315B2 HIV integrase inhibitors
Tricyclic compounds of Formula (I) are inhibitors of HIV integrase and inhibitors of HIV replication: wherein bond a, ring A, R1, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
US07741308B2 DBAIT and uses thereof
The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses novel double-stranded nucleic acid molecules. that act as baits and hijack the holocomplex of enzymes responsible of DNA DSB sensing, signaling and/or repair pathways, in particular the non homologous end joining (NHEJ) pathway of DSB repair.The invention discloses the use of these molecules as adjuvant compositions to be used in association with a DNA breaking treatment, particularly radiotherapy or chemotherapy, in combination with a pharmaceutically acceptable carrier, in an efficient amount to be introduced in the tumor cell nuclei in order to neutralize transiently their DNA repair capacity and trigger their death.
US07741306B2 Regulation of oncogenes by microRNAs
Naturally occurring miRNAs that regulate human oncogenes and methods of use thereof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA ,or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA. The compositions are administered to a subject prior to administration of a cytotoxic therapy in an amount effective to sensitize cells or tissues to be treated to the effects of the cytotoxic therapy.
US07741303B2 Stimulation of cellular regeneration and differentiation in the inner ear
The present invention provides methods for stimulating the formation of inner ear cells, including inner ear sensory hair cells and inner ear support cells. The methods of the present invention damage and/or kill inner ear cells, and stimulate the formation of new, inner ear cells.
US07741298B2 Method and compositions for inhibiting tumorigenesis
The present invention relates to compounds, small interfering RNAs and compositions and methods of inhibiting tumorigenesis using agents that inhibit the sonic hedgehog and GLI signaling pathway, including agents that inhibit GLI expression, synthesis and/or function. The present invention also relates to particular biomarkers that can be used in the diagnosis and prognosis of cancer. Methods of treating cancer, including glioblastomas, medulloblastomas, basal cell carcinomas, prostate cancer and small cell and non-small cell lung cancer are also provided using small organic compounds, siRNAs and blocking antibodies that inhibit or block the SHH/GLI pathway.
US07741297B2 Immunostimulatory, covalently lipidated oligonucleotides
Covalently lipidated oligonucleotides comprising the CpG dinucleotide unit, or an analogue thereof, may be used as immunostimulatory agents to protect against a disease caused by a cancer cell or a pathogen, either alone or in conjunction with immunogens and/or non-immunological agents.Lipidated oligonucleotides with special backbones, lipidated oligonucleotides with fewer than eight nucleotides, and lipidated oligonucleotides comprising a plurality of CpG dinucleotide-containing segments connected by a long internucleoside linkage are of particular interest. These compounds are also novel per se.
US07741294B1 Non-standard nucleobases implementing the isocytidine and isoguanosine hydrogen bonding patterns
This invention provides compositions of matter that, when incorporated into an oligonucleotide, present to a complementary strand in a Watson-Crick pairing geometry a pattern of hydrogen bonds that is different from the pattern presented by adenine, guanine, cytosine, and thymine. Most specifically, this invention discloses and claims compositions of matter that present the same hydrogen bonding patterns as the isocytidine and isoguanosine nucleobases, but do not have unfavorable tautomeric forms, do not become disassociated from their sugar, and do not make major groove interactions, as much, as easily, or as strongly as isocytidine and isoguanosine.
US07741285B2 APO-2 ligand/trail formulations
The present invention relates generally to Apo2L/TRAIL purification involving crystallization.
US07741282B2 ApO2 ligand/TRAIL formulations
The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.
US07741280B2 Multimeric molecules, the preparation method thereof and use of same for the preparation of medicaments
The invention relates to a multimeric molecule which can imitate a natural multimeric proteinaceous ligand. The invention also relates to a multimeric molecule as defined above which is characterised in that it has the following general formula: A-Xn, wherein: n is equal to 3, 4, 5 or 6; A denotes a chemical group which is functionalised by at least three amine functions or COOH functions; and X denotes a D, B-D or B(D)-D′ group, in which B is a spacer and D and D′ are peptides or pseudopeptides corresponding to a sequence which is derived from the ligand and selected from residual matter forming the interface with the receptor and which can interact with the receptor.
US07741276B2 Use of interleukin-18 inhibitors to inhibit tumor metastasis
Use of IL-18 inhibitors in tumor metastasis is disclosed.
US07741274B2 Casein derived peptides and uses thereof in therapy
Biologically active peptides that are derived from or are similar to sequences identical with the N-terminus of the oS1 fraction of milk casein. These peptides are capable of stimulating and enhancing immune response, protecting against viral infection, normalizing serum cholesterol levels, and stimulating hematopoiesis. The casein-derived peptides are non-toxic and can be used to treat and prevent immune pathologies, hypercholesterolemia, hematological disorders and viral-related diseases.
US07741271B2 Methods of modulating immune responses by modulating tim-1, tim-2 and tim-4 function
The invention relates to methods of modulating immune responses in a subject, such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them.
US07741268B2 Liquid pharmaceutical formulations of FSH and LH together with a non-ionic surfactant
The invention relates to the field of pharmaceutical formulations of follicle-stimulating hormone (FSH), luteinising hormone (LH), and mixtures of FSH and luteinising hormone (LH), and to methods of producing such formulations. The invention provides a liquid or freeze-dried formulation of FSH, or LH, or FSH and LH comprising a surfactant selected from Pluronic® F77, Pluronic F87, Pluronic F88 and Pluronic F68.
US07741266B2 Process for preparing scented cellulosics and products prepared thereby
The present invention provides a process for optimizing the fragrance of a scented cellulosic.
US07741262B2 Compositions including hardness ions and gluconate and methods employing them to reduce corrosion and etch
The present invention relates to compositions including a water soluble magnesium salt, water soluble calcium salt, and gluconate, which have a beneficial effect on corrosion during cleaning. The present compositions can reduce corrosion of a variety of surfaces including glass, aluminum, chrome, copper, and steel. The present invention also relates to methods employing these compositions.
US07741258B2 Lubricating oil composition
A lubricating oil composition comprising base oil, one or more glycerol esters selected from glycerol monooleate and/or glycerol dioleate, optionally in combination with glycerol trioleate, wherein said composition further comprises one or more dispersant-viscosity index improver compounds and an additive amount of one or more additional polyhydric alcohol esters; and a method of lubricating an internal combustion engine comprising applying said lubricating oil composition thereto.
US07741256B2 Lubricant composition, expandable shaft, and steering system using the same
A lubricant composition contains poly-α-olefin oil having a kinematic viscosity of 1500 to 13000 mm 2/s (40° C.) as a base oil and from 45 to 50% by weight of a thickener composed of polytetrafluoroethylene. The lubricant composition may be used for lubricating an expandable shaft having a pair of shaft members filled with the lubricant composition to prevent stick-slip from occurring when a high surface pressure is applied thereto, thereby allowing consistent maintenance of good lubricating performance. Such an expandable shaft may be incorporated advantageously into a steering system as an intermediate shaft into an area between a steering shaft and a rack-and-pinion mechanism.
US07741246B2 Herbicide composition and weed-controlling method using the same
Provided is a herbicide composition which comprises a combination in a specific proportion of 2-[(4,6-dimethoxypyrimidin-2-yl)hydroxymethyl]-6-methoxymethyl-N-difluoromethanesulfonylanilide as the component (A) and either one of fifteen kinds of compounds including 4-(2-chlorophenyl)-N-cyclohexyl-N-ethyl-4,5-dihydro-5-oxo-1H-tetrazole-1-carboxamide as the component (B), none of which has been used in combination with the compound as the component (A). By an application of the herbicide composition to a paddy field in a specific dose, an excellent herbicidal effect is obtained against various kinds of weeds growing in paddy fields and the chemical damages thereof to paddy rice is extremely low.
US07741244B2 Fungicide compositions
This invention relates to agricultural compositions that find particular use as a fungicide composition. The fungicide composition can include one or more fatty acids and one or more organic acids different from the fatty acid. The organic acid can but need not exhibit any fungicidal activity; however, when combined with a fatty acid, the organic acid functions as a potent synergist for the fatty acid as a fungicide. Additionally, the fungicide composition can include other components such as emulsifiers, adjuvants, surfactants and diluents. The fungicide composition significantly reduces or prevents the fungal infection of cash crops including vegetables, fruits, berries, seeds, grains and at higher application rates, can also be used as a harvest aid or desiccant for harvested crops such as potatoes.
US07741242B2 Palladium catalyst composition
The present invention discloses 1) a catalyst composition consisting of a crosslinked organic polymer compound and a palladium catalyst, wherein said catalyst is physically carried on said crosslinked organic polymer compound, 2) a manufacturing method of the above catalyst composition 1), characterized by homogenizing a straight chain organic polymer compound, having a crosslinkable functional group, and a palladium catalyst in a solvent dissolving said straight chain organic polymer compound, then depositing a composition thus formed and subjecting the crosslinkable functional group in said deposit to a crosslinking reaction, 3) a method for substitution reaction at an allyl position, characterized by reacting an allyl carbonate and a neucleophilic agent in the presence of the above catalyst composition 1), and 4) a method for oxidizing an alcohol, characterized by subjecting the above catalyst composition 1) to reaction with an alcohol.
US07741240B2 Transition metal compounds for olefin polymerization and oligomerization
This invention relates to new transition metal catalyst compounds represented by the formula (I): where: M and M′ are, independently, a group 8, 9, 10 or 11 transition metal, preferably Ni, Co, Pd, Cu or Fe; each R group is, independently, is, hydrogen, or a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituents, and optionally, adjacent R groups may join together to form a substituted or unsubstituted, saturated, partially unsaturated, or aromatic cyclic or polycyclic substituent; R′ is hydrogen, or a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituents, and optionally, adjacent R groups may join together with R′ to form a substituted or unsubstituted, saturated, partially unsaturated, or aromatic cyclic or polycyclic substituent; each X group is, independently, is, hydrogen, a halogen, or a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituents, and optionally, adjacent X groups may join together to form a substituted or unsubstituted, saturated, partially unsaturated, or aromatic cyclic or polycyclic substituent; m and m′ are, independently, 0, 1, 2, or 3; z and z′ are, independently, 0, 1, 2, or 3; N is nitrogen; Q is hydrogen, or a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituents; Q′ is hydrogen, or a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituents; and L is a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituent.
US07741238B2 Spinel sintered body, light transmitting window and light transmitting lens
A low-cost spinel sintered body having small polarization and high heat-conductivity is provided. Also, a useful light-transmitting window and light-transmitting lens for light-emitting device is provided. For such purpose, the spinel sintered body of the present invention has a contrast ratio of 300 or more in the case of white light, where the contrast ratio is defined as the quotient obtained by dividing an amount of transmitting light in the case of being arranged between two polarizing plates, the polarizing directions of the two polarizing plates being parallel to each other, by an amount of transmitting light in the case of being arranged between two polarizing plates, the polarizing directions of the two polarizing plates being orthogonal to each other.
US07741234B2 Embossed fibrous structure product with enhanced absorbency
A fibrous structure product comprising one or more plies of fibrous structure; a basis weight from about 10 lbs/3000 ft2 to about 50 lbs/3000 ft2; from 16% to about 40% of hardwood fibers, in one embodiment eucalyptus fibers, wherein the starting hardwood fibers have a Runkel Ratio of from 4.5 to about 15 and a fiber count of from about 12 fibers/gram to about 35 fibers/gram; and a Residual Water Value from about 0.001 to about 0.18. In one embodiment the product comprises two or more plies of fibrous structure, a basis weight from about 25 lbs/3000 ft2 to about 50 lbs/3000 ft2 and from about 23% to about 40% of hardwood fibers. In another embodiment at least one of the piles of the fibrous structure product further comprises a plurality of embossments thereon comprising an embossment height of from about 600 μm to about 1,200 μm.
US07741233B2 Flame-retardant treatments for cellulose-containing fabrics and the fabrics so treated
Provided herein are several inventive fabrics having warp yarns and fill yarns, where the warp yarns preferably are an intimate blend of synthetic and cellulosic fibers and where the fill yarns are preferably a patternwise arrangement of synthetic and cellulosic yarns. Such fabric possesses sufficient cellulosic content (i.e., at least 45% by weight) to be easily rendered flame retardant, while simultaneously possessing sufficient synthetic content (i.e., at least 30% by weight) to be abrasion resistant and long-lasting. In one embodiment, the subject fabrics are treated with one or more flame retardant chemicals, typically in the presence of ammonia gas. In a second embodiment, the subject fabrics are coated on one side with an elastomeric composition into which a flame retardant compound has been incorporated. In yet another embodiment, the subject fabrics are both treated and coated to achieve flame retardance.
US07741230B2 Highly-selective metal etchants
A highly selective metal wet etchant with an active ingredient comprising one or more types of molecules having two or more oxygen atoms is described. In one embodiment, the wet etchant is utilized to pattern a metal layer in a semiconductor structure. In another embodiment, a highly selective metal wet etchant with an active ingredient comprising one or more types of molecules having two or more oxygen atoms is used to pattern a metal gate electrode in a replacement gate processing scheme.
US07741222B2 Etch stop structure and method of manufacture, and semiconductor device and method of manufacture
An etch stop layer is formed over a first structure by depositing a metal oxide material over the first structure and annealing the deposited metal oxide material. A second structure is formed over the etch stop layer, and a formation is etched through the second structure using the etch stop layer as an etch stop.
US07741221B2 Method of forming a semiconductor device having dummy features
A method for forming a semiconductor device includes providing a plurality of features in a layout, selecting critical features from the plurality of features, placing a first plurality of short-range dummy etch features in the layout at a first distance from the critical features to increase the feature density near the critical features, wherein each of the first plurality of short-range dummy etch features has a first width, removing at least one of the first plurality of short-range dummy etch features from the layout that will subsequently interfere with the electrical performance of at least one active feature so that a second plurality of short-range dummy etch features remains, and using the layout to pattern a layer on a semiconductor substrate.
US07741220B2 Semiconductor device and manufacturing method thereof
The present invention discloses a semiconductor device and a manufacturing method thereof which improves its characteristics even though it is miniaturized. According to one aspect of the present invention, it is provided a semiconductor device comprising a first semiconductor element device including a pair of first diffusion layers formed in the semiconductor substrate with a first gate electrode therebetween, and a first conductor layer formed in the first diffusion layer and having an internal stress in a first direction, and a second semiconductor element device including a pair of second diffusion layers formed in the semiconductor substrate with a second gate electrode therebetween, and a second conductor layer formed in the second diffusion layer, having an internal stress in a second direction opposite to the first direction, and constituted of the same element as that of the first conductor layer.
US07741217B2 Dual workfunction silicide diode
A CMOS diode and method of making it are disclosed. In one embodiment, the diode comprises a silicon substrate having an N doped region and a P doped region. A first silicide region is formed on the N doped region of the silicon substrate, and a second silicide region formed on the P doped region of the silicon substrate. The first silicide region is comprised of a material having a bandgap value lower than the bandgap value of the material comprising the second silicide region. The result is a diode where the workfunction of each region of silicide more closely matches the workfunction of the doped silicon it contacts, resulting in reduced contact resistance. This provides for a diode with improved performance characteristics.
US07741215B2 Semiconductor device and method for manufacturing the same
The present invention provides a method for manufacturing a semiconductor device, including the step of forming a hole penetrating an insulating film over a semiconductor substrate, wherein the step includes the steps of forming a pedestal at a position where a hole to be formed; forming an insulating film to bury the pedestal; forming a first hole in the insulating film so as to expose a top surface of the pedestal; and removing the pedestal to form a second hole continuous with the first hole to form a hole penetrating the insulating film.
US07741214B2 Method of forming a semiconductor device featuring copper wiring layers of different widths having metal capping layers of different thicknesses formed thereon
In a semiconductor device, an insulating interlayer is provided above a semiconductor substrate, and a plurality of first wiring layers and a plurality of second wiring layers are formed in the insulating interlayer. The first wiring layers are substantially composed of copper, and are arranged in parallel at a large pitch. The second wiring layers are substantially composed of copper, and are arranged in parallel at a small pitch. A first metal capping layer is formed on each of the first wiring layers, and a second metal capping layer is formed on each of the second wiring layers. The second metal capping layer has a smaller thickness than that of the first metal capping layer.
US07741213B2 Semiconductor device, DRAM integrated circuit device, and method of producing the same
A semiconductor device with a multi-layer wiring structure includes a first conductive region: a second conductive region that has an upper surface located in a higher position than the first conductive region with respect to the substrate; an insulating that covers the first and second conductive regions; a wiring groove that is formed in the insulating film so as to expose the second conductive region; a contact hole that is formed in the insulating film so as to expose the first conductive region; and a wiring pattern that fills the wiring groove and the contact hole. In this semiconductor device, the upper surface of the wiring pattern is located on the same plane as the upper surface of the insulating film.
US07741211B2 Method for manufacturing a semiconductor device
A semiconductor device can include a first interlayer dielectric layer disposed on a substrate, and an air gap defined in a portion of the first interlayer dielectric layer. The air gap can be formed within trenches etched into the first interlayer dielectric layer. An etch stop layer is disposed on the first interlayer dielectric layer and the air gap, and includes a hole communicating with the air gap.
US07741203B2 Method of forming gate pattern of flash memory device including over etch with argon
A method of forming a gate pattern of a flash memory device may include forming a tunnel dielectric layer, a conductive layer for a floating gate, a dielectric layer, a conductive layer for a control gate, a metal electrode layer, and a hard mask film over a semiconductor substrate. The metal electrode layer may be etched such that a positive slope of an upper sidewall may be formed larger than a positive slope of a lower sidewall of the metal electrode layer. The conductive layer for the control gate, the dielectric layer, and the conductive layer for the floating gate may then be etched. High molecular weight argon gas, for example, may be used to improve an anisotropic etch characteristic of plasma. Over etch of a metal electrode layer may be decreased to reduce a bowing profile. Resistance of word lines can be decreased and electrical properties can be improved.
US07741202B2 Method of controlling interface layer thickness in high dielectric constant film structures including growing and annealing a chemical oxide layer
A method for controlling interface layer thickness in high dielectric constant (high-k) film structures found in semiconductor devices. According to one embodiment, the method includes providing a monocrystalline silicon substrate, growing a chemical oxide layer on the monocrystalline silicon substrate in an aqueous bath, vacuum annealing the chemical oxide layer, depositing a high-k film on the vacuum annealed chemical oxide layer, and optionally vacuum annealing the high-k film. According to another embodiment, the method includes depositing a high-k film on a chemical oxide layer, and vacuum annealing the high-k film.
US07741193B2 SOI structure having a SiGe layer interposed between the silicon and the insulator
A semiconductor structure and a method of manufacturing a silicon on insulator (SOI) structure having a silicon germanium (SiGe) layer interposed between the silicon and the insulator. According to one manufacturing method, a first SiGe layer, a silicon layer, and a second SiGe layer are epitaxially grown in sequence over a first substrate, and then an insulating layer is formed on the second SiGe layer. Then, impurity ions are implanted into a predetermined location of the first substrate underlying the first SiGe layer to form an impurity implantation region. A second substrate is bonded to the insulating layer on the first substrate. After the first substrate is separated along the impurity implantation region and removed, the first SiGe layer remaining on the surface of the separated region is removed so that the surface of the silicon layer may be exposed.
US07741184B2 Fin device with capacitor integrated under gate electrode
A fin-type field effect transistor (FinFET) has a fin having a center channel portion, end portions comprising source and drain regions, and channel extensions extending from sidewalls of the channel portion of the fin. The structure also includes a gate insulator covering the channel portion and the channel extensions, and a gate conductor on the gate insulator. The channel extensions increase capacitance of the channel portion of the fin.
US07741182B2 Method of fabricating a dual gate FET
The invention provides a method of fabricating an extremely short-length dual-gate FET, using conventional semi-conductor processing techniques, with extremely small and reproducible fins with a pitch and a width that are both smaller than can be obtained with photolithographic techniques. On a protrusion (2) on a substrate (1), a first layer (3) and a second layer (4) are formed, after which the top surface of the protrusion (2) is exposed. A portion of the first layer (3) is selectively removed relative to the protrusion (2) and the second layer (4), thereby creating a fin (6) and a trench (5). Also a method is presented to form a plurality of fins (6) and trenches (5). The dual-gate FET is created by forming a gate electrode (7) in the trench(es) (5) and a source and drain region. Further a method is presented to fabricate an extremely short-length asymmetric dual-gate FET with two gate electrodes that can be biased separately.
US07741181B2 Methods of forming mixed gate CMOS with single poly deposition
A method for fabricating metal gate and polysilicon gate FET devices on the same chip is disclosed. The method avoids the use of two separate masks during gate stack fabrication of the differing gates. By using a single mask, tighter NFET to PFET distances can be achieved, and the fabrication process is simplified. After blanket disposing layers for the fabrication of the metal gate stack, a covering protective material layer is formed, again in blanket fashion. A block level mask is used to clear the surface for the gate insulator formation in the poly gate device regions. During oxidation, which forms the gate dielectric for the poly gate devices, the protective material prevents damage of the metal gate device regions. Following oxidation, a single common polysilicon cover is disposed in blanket manner for continuing the fabrication of the gate stacks. The protective material is selected in such a way to be either easily removable upon oxidation, or to be conductive upon oxidation. In this latter case the oxidized protective material is incorporated into the metal gate stack, which incorporation results in a novel CMOS structure.
US07741180B2 Method of manufacturing semiconductor device with recess gate transistor
A method of manufacturing a semiconductor device includes forming a plurality of recesses in a semiconductor substrate, forming a gate insulating film in the plurality of recesses, and a plurality of gate electrodes on the gate insulating film in the plurality of recesses, forming an insulating layer on the semiconductor substrate and the plurality of gate electrodes, forming a plurality of contact holes in the insulating layer, the contact holes being formed between adjacent ones of the plurality of gate electrodes, implanting a first impurity into the semiconductor substrate through the plurality of contact holes to form each of source and drain regions in contact with the gate insulating film.
US07741178B2 Method for fabricating vertical channel transistor in semiconductor device
A method for fabricating a vertical channel transistor in a semiconductor device includes forming a plurality of pillars arranged in a first direction and a second direction crossing the first direction over a substrate, wherein each of the pillars includes a hard mask pattern thereon, forming a bit line region in the substrate between the pillars, forming a first sidewall insulation layer on a sidewall of each of the pillars, forming an insulation layer for filling a space between the pillars, forming a mask pattern for exposing the substrate between lines of the pillars arranged in the first direction over a resulting structure including the insulation layer, etching the insulation layer and the substrate using the mask pattern as an etch barrier to form a trench for defining a bit line in the substrate, and forming a second sidewall insulation layer over a resulting structure including the trench.
US07741176B2 Method for fabricating a cylindrical capacitor including implanting impurities into the upper sections of the lower electrode to prevent the formation of hemispherical grain silicon on the upper sections
A method for fabricating a semiconductor device is disclosed. The semiconductor device includes a capacitor and a support insulator. The capacitor includes a cylindrical electrode. The cylindrical electrode comprises upper and lower sections. The lower section has a roughened inner surface and an outer surface supported by the support insulator. The upper section upwardly projects from the support insulator. An initial cylindrical electrode is formed, wherein the initial cylindrical electrode comprises an initial upper section and an initial lower section which correspond to the upper section and the lower section of the cylindrical electrode, respectively. The initial upper section is supported by the support insulator. Specific impurities are implanted into the initial upper section, wherein the specific impurities serve to prevent the initial upper section from being roughened. Then, the initial cylindrical electrode is exposed to a roughening process so that the initial lower section is roughened to be the lower section.
US07741175B2 Methods of forming capacitors
A method of forming a capacitor includes forming a first capacitor electrode over a semiconductor substrate. A capacitor dielectric region is formed onto the first capacitor electrode. The capacitor dielectric region has an exposed oxide containing surface. The exposed oxide containing surface of the capacitor dielectric region is treated with at least one of a borane or a silane. A second capacitor electrode is deposited over the treated oxide containing surface. The second capacitor electrode has an inner metal surface contacting against the treated oxide containing surface. Other aspects and implementations are contemplated.
US07741174B2 Methods of forming pad structures and related methods of manufacturing recessed channel transistors that include such pad structures
Methods of forming pad structures are provided in which a first contact region and second contact regions are formed in an active region of a substrate. An insulating interlayer is formed on the substrate. The insulating interlayer has a first opening that exposes the first contact region and the second contact regions. First conductive pads are formed in the first opening. Each first conductive pad is in electrical contact with a respective one of the second contact regions. Spacers are formed, where each spacer is on a sidewall of a respective one of the first conductive pads. Finally, a second conductive pad is formed between the first conductive pads and in electrical contact with the first contact region to complete the pad structure.
US07741171B2 Oxygen-rich layers underlying BPSG
An integrated circuit structure and a method of forming the same are provided. The method includes providing a surface; performing an ionized oxygen treatment to the surface; forming an initial layer comprising silicon oxide using first process gases comprising a first oxygen-containing gas and tetraethoxysilane (TEOS); and forming a silicate glass over the initial layer. The method may further include forming a buffer layer using second process gases comprising a second oxygen-containing gas and TEOS, wherein the first and the second process gases have different oxygen-to-TEOS ratio.
US07741170B2 Dielectric structure in nonvolatile memory device and method for fabricating the same
A dielectric structure in a nonvolatile memory device and a method for fabricating the same are provided. The dielectric structure includes: a first oxide layer; a first high-k dielectric film formed on the first oxide layer, wherein the first high-k dielectric film includes one selected from materials with a dielectric constant of approximately 9 or higher and a compound of at least two of the materials; and a second oxide layer formed on the first high-k dielectric film.
US07741169B2 Mobility enhancement by strained channel CMOSFET with single workfunction metal-gate and fabrication method thereof
The present invention provides a complementary metal-oxide-semiconductor (CMOS) device and a fabrication method thereof. The CMOSFET device includes a compressively strained SiGe channel for a PMOSFET, as well as a tensile strained Si channel for an NMOSFET, thereby enhancing hole and electron mobility for the PMOSFET and the NMOSFET, respectively. As such, the threshold voltages of the two types of transistors can be obtained in oppositely symmetric by single metal gate.
US07741168B2 Systems and methods for fabricating nanometric-scale semiconductor devices with dual-stress layers using double-stress oxide/nitride stacks
Systems and methods for fabricating semiconductor devices with dual-stress layers using double-stress oxide/nitride stacks. A method comprises providing NMOS and PMOS regions, selectively forming a dual-stack tensile stress layer over the NMOS region by depositing a tensile silicon nitride layer over the NMOS and PMOS regions, depositing a tensile silicon oxide layer over the tensile silicon nitride layer, removing a portion of the tensile silicon oxide layer from the PMOS region, and removing a portion of the tensile silicon nitride layer from the NMOS region and selectively forming a dual stack compressive stress layer over the PMOS region by depositing a compressive silicon nitride layer over the NMOS and PMOS regions, depositing a compressive silicon oxide layer over the compressive silicon nitride layer, removing a portion of the compressive silicon oxide layer from the NMOS region, and removing a portion of the compressive silicon nitride layer from the NMOS region.
US07741167B2 Semiconductor device comprising NMOS and PMOS transistors with embedded Si/Ge material for creating tensile and compressive strain
By forming a substantially continuous and uniform semiconductor alloy in one active region while patterning the semiconductor alloy in a second active region so as to provide a base semiconductor material in a central portion thereof, different types of strain may be induced, while, after providing a corresponding cover layer of the base semiconductor material, well-established process techniques for forming the gate dielectric may be used. In some illustrative embodiments, a substantially self-aligned process is provided in which the gate electrode may be formed on the basis of layer, which has also been used for defining the central portion of the base semiconductor material of one of the active regions. Hence, by using a single semiconductor alloy, the performance of transistors of different conductivity types may be individually enhanced.
US07741158B2 Method of making thermally enhanced substrate-base package
An array-type package encasing one or more semiconductor devices. The package includes a dielectric substrate having opposing first and second sides with a plurality of electrically conductive vias and a centrally disposed aperture extending from the first side to the second side. A heat slug has a mid portion extending through the aperture, a first portion adjacent the first side of the substrate with a cross sectional area larger than the cross sectional area of the aperture and an opposing second portion adjacent the second side of the substrate. One or more semiconductor devices are bonded to the first portion of the heat slug and electrically interconnected to the electrically conductive vias. A heat spreader having a first side and an opposing second side is spaced from the semiconductor devices and generally parallel with the heat slug, whereby the semiconductor devices are disposed between the heat spreader and the heat slug. A molding resin encapsulates the semiconductor devices and at least the first side of the substrate, the first portion of the heat slug and the first side of the heat spreader.
US07741156B2 Semiconductor device and method of forming through vias with reflowed conductive material
A semiconductor device is made by providing a first semiconductor wafer having semiconductor die. A gap is made between the semiconductor die. An insulating material is deposited in the gap. A portion of the insulating material is removed to form a first through hole via (THV). A conductive lining is conformally deposited in the first THV. A solder material is disposed above the conductive lining of the first THV. A second semiconductor wafer having semiconductor die is disposed over the first wafer. A second THV is formed in a gap between the die of the second wafer. A conductive lining is conformally deposited in the second THV. A solder material is disposed above the second THV. The second THV is aligned to the first THV. The solder material is reflowed to form the conductive vias within the gap. The gap is singulated to separate the semiconductor die.
US07741151B2 Integrated circuit package formation
Integrated circuit packages are formed from a panel where the panel is separated by laser cutting the panel. In some embodiments, the panel is attached to the carrier for the formation of interconnect layers on the panel. Afterwards, the panel is cut with a laser while on the carrier to separate the integrated circuit packages. A tape or other type of structure may be attached to the top of the packages after the laser cutting. The integrated circuit packages are removed from the carrier by releasing the adhesive and removing the integrated circuit packages with the tape. The packages are then removed from the tape.
US07741148B1 Semiconductor device and method of forming an interconnect structure for 3-D devices using encapsulant for structural support
A semiconductor device has a first interconnect structure formed over a first side of a substrate. A semiconductor die is mounted to the first interconnect structure. An encapsulant is deposited over the semiconductor die and first interconnect structure for structural support. A portion of a second side of the substrate, opposite the first side of the substrate, is removed to reduce its thickness. The encapsulant maintains substrate robustness during thinning process. A TSV is formed through the second side of the substrate to the first interconnect structure. A second interconnect structure is formed in the TSV. The TSV has a first insulating layer formed over the second side of the substrate and first conductive layer formed over the first insulating layer and into the TSV. The second interconnect structure has a second conductive layer formed over the first conductive layer in an area away from the TSV.
US07741145B2 Highly efficient organic light-emitting device using substrate or electrode having nanosized half-spherical convex and method for preparing the same
The present invention provides a transparent substance formed with a plurality of continuous half-spherical convexes having a diameter of 25˜1,000 nm on its first main surface; an organic light-emitting device comprising a substrate, a first electrode, an organic material layer(s) and a second electrode, sequentially, characterized by having a plurality of continuous half-spherical convexes having a diameter of 25˜1,000 nm on the underside of the substrate that does not contact the first electrode and/or the upside of the second electrode that does not contact the organic material layer; and a method for preparing same using a porous aluminum oxide layer forming process.
US07741144B2 Plasma treatment between deposition processes
Embodiments of the present invention include an improved method of forming a thin film solar cell device using a plasma processing treatment between two or more deposition steps. Embodiments of the invention also generally provide a method and apparatus for forming the same. The present invention may be used to advantage to form other single junction, tandem junction, or multi-junction solar cell devices.
US07741140B2 Methods, apparatus, and rollers for cross-web forming of optoelectronic devices
Apparatus and methods for forming optoelectronic devices such as an array of light emitting diodes or photovoltaic cells in one embodiment a roll-to-roll process in which a uniquely configured roller having a raised spiral coating surface is aligned with a plurality of first electrodes disposed on an angle on a substrate for coating a plurality of spaced-apart angled coated strips of optoelectronic materials along the cross-web direction of the substrate.
US07741138B2 Semiconductor device and fabricating method thereof
A semiconductor device and fabricating method thereof are disclosed, by which channel mobility is enhanced and by which effect of flicker noise can be minimized. Embodiments relate to a method of fabricating a semiconductor device which includes forming a first epi-layer over a substrate, forming a second epi-layer over the first epi-layer, forming a gate electrode over the second epi-layer, forming a spacer over both sides of the gate electrode, etching an area adjacent both sides of the spacer to a depth of the substrate, forming an LDD region in a region under the spacer, and forming a third epi-layer for a source/drain region over the etched area adjacent both of the sides of the spacer.
US07741137B2 Method of manufacturing electro-optical device
A method of manufacturing a plurality of electro-optical devices by notching, dicing, and cutting a composite substrate obtained by adhering a first substrate and a second substrate which faces the first substrate with an electro-optical layer interposed therebetween.
US07741135B2 Method of manufacturing light emitting display
A method of manufacturing a light emitting display including an image display part formed on a substrate and a pad part including at least one terminal electrically connected to the image display part. The method includes forming thin film transistors and at least one electroluminescent device electrically connected to the thin film transistors and including a first electrode layer, an emission layer, and a second electrode layer on the image display part, forming a protection layer on the second electrode layer of the electroluminescent device and the pad part, sealing the image display part on the protection layer, and removing the protection layer formed at least on the pad part to expose the terminals. Therefore, it is possible to easily remove the protection layer formed of organic material or inorganic material formed on the pad part without an additional mask.
US07741134B2 Inverted LED structure with improved light extraction
A light source and method for fabricating the same are disclosed. The light source includes a substrate and a light emitting structure. The substrate has a first surface and a second surface, the second surface including a curved, convex surface with respect to the first surface of the substrate. The light emitting structure includes a first layer of a material of a first conductivity type overlying the first surface, an active layer overlying the first layer, the active layer generating light when holes and electrons recombine therein, and a second layer includes a material of a second conductivity type overlying the active layer and a second surface opposite to the first surface. A mirror layer overlies the light emitting structure.
US07741131B2 Laser processing of light reflective multilayer target structure
A solution to an interference effect problem associated with laser processing of target structures entails adjusting laser pulse energy or other laser beam parameter, such as laser pulse temporal shape, based on light reflection information of the target structure and passivation layers stacked across a wafer surface or among multiple wafers in a group of wafers. Laser beam reflection measurements on a target link measurement structure and in a neighboring passivation layer area unoccupied by a link enable calculation of the laser pulse energy adjustment for a more consistent processing result without causing damage to the wafer. For thin film trimming on a wafer, similar reflection measurement information of the laser beam incident on the thin film structure and the passivation layer structure with no thin film present can also deliver the needed information for laser parameter selection to ensure better processing quality.
US07741125B2 Biosensor, biosensor measuring apparatus and measurement method
A biosensor and a biosensor measuring apparatus whose performance can be easily determined by an ordinary user are provided. A biosensor 100 includes a substrate 1 having a quality deciding section 13 and a sample receiving section 15 provided on the substrate 1 to which a sample is supplied. The quality deciding section 13 includes a moisture absorbing material changed in color through absorption of moisture. The sample receiving section 15 has a reagent section 7 including an enzyme reacted with a test substance as a substrate. The quality deciding section 13 includes a recess 17 formed in the substrate 1, the moisture absorbing material 16 disposed in the recess 17 and a film 18 with no air permeability substantially covering the opening of the recess 17 and closely adhered to the moisture absorbing material 16. Cobalt salt is used as the moisture absorbing material 16.
US07741124B2 Detection procedures for fibrinogen and/or fibrinogen derivatives
Described are determination procedures for fibrinogen and/or fibrinogen-derivatives by matrix-independent turbidimetry. In the FIFTA called procedure the fibrinogen activity is preferably determined in an undiluted sample by addition of thrombin and/or albumin, as well as polybrene if appropriate, in PBS and determination of the increase in absorbance at 405 nm. In the FIATA called procedure the fibrinogen-concentration and/or the concentration of fibrinogen-derivatives is preferably determined by addition of vancomycin and determination of the increase in turbidity at 405 nm. It is standardized by usage of plasma standards of known fibrinogen-activity and/or fibrinogen-concentration.
US07741123B2 Microfluidic device with thin-film electronic devices
A microfluidic device for analysis of a sample. The microfluidic device includes a substrate portion that at least partially defines a chamber for receiving the sample. The substrate portion includes a substrate having a surface. The substrate portion also includes a plurality of thin-film layers formed on the substrate adjacent the surface. The thin-film layers form a plurality of electronic devices. Each of at least two of the electronic devices is formed by a different set of the thin-film layers.
US07741120B2 Multifunctional nanocrystals
Multifunctional nanocomposites are provided including a core of either a magnetic material or an inorganic semiconductor, and, a shell of either a magnetic material or an inorganic semiconductor, wherein the core and the shell are of differing materials, such multifunctional nanocomposites having multifunctional properties including magnetic properties from the magnetic material and optical properties from the inorganic semiconductor material. Various applications of such multifunctional nanocomposites are also provided.
US07741115B2 Antibodies that bind LDCAM
The invention is directed to LDCAM as a purified and isolated protein, the DNA encoding the LDCAM, host cells transfected with cDNAs encoding LDCAM, processes for preparing LDCAM polypeptides and compositions and methods for treating utilizing LDCAM polypeptides.
US07741113B2 Cell-specific molecule and method for importing DNA into osteoblast nuclei
A plasmid, viral or linear DNA molecule containing a nucleic acid sequence derived from the promoter region of the hCol1α2 gene, which is selectively transported into the nuclei of cells in the osteoblast lineage. The sequence can be used independently as a nuclear entry sequence only, and/or as a nuclear entry sequence without regard to position, in a vector or linear DNA that directs gene expression and nuclear entry. The disclosure further includes a chimeric DNA sequence derived by the addition of osteoblast-specific enhancer sequences to the nuclear entry sequence/promoter sequence, to increase osteoblast-specific expression while retaining osteoblast-specific nuclear import. An enhancer sequence is derived from the promoter region of the human Core Binding Factor alpha 1 (Cbfa1/Runx2) gene. The Cbfa1/Runx2 promoter can be added to the sequence derived from, or alternatively, comprising the promoter region of the hCol1α2 gene. Also provided are methods of use of the novel sequences.
US07741108B2 Bacteria sensor and method
Bacteria accumulations on the interior walls of a fluid conduit are detected by placing a bacterial target substrate in the conduit. The substrate is structured to allow bacteria to colonize it at at least the rate of accumulation expected on the conduit walls or at an accelerated rate in order to preempt normal bacteria accumulation on the walls. A bacteria getter may be used to accelerate bacterial colonization of the substrate. An excitation signal interrogating the substrate causes autofluorescence in the presence of bacteria, specifically from NADH and/or NADPH present. The autofluorescent emission is transmitted to a detector and processor. In one system when the presence of bacteria at a preset level is detected there is initiated a diversion of the fluid into an auxiliary subsystem during which the primary subsystem is remediated. In one configuration, a wall portion is transparent and the biofilm target substrate is integral with the transparent wall portion and the sensor head is attached to the outside of the transparent wall portion. It can be made as a removable and/or disposable cell in which the transparent wall portion is a glass plug that fits into a hole in the conduit. The biofilm target substrate can be a getter affinity surface formed on the inside surface of the glass plug. Various means are used for obtaining accelerated biofilm growth.
US07741104B2 Capillary array and related methods
The invention provides methods and devices for detecting the presence of one or more target analytes in a sample employing a channel having affixed therein one or more binding partners for each target analyte. Assays are carried out by transporting the sample through the channel to each successive binding partner so that target analyte present in said sample binds to the corresponding binding partner. The sample is then transported beyond the binding partner(s), followed by detection of any target analyte bound to each binding partner. In one embodiment, binding efficiency is increased by the use of segmented transport, wherein a first bolus or bubble of a fluid that is immiscible with the sample precedes the sample during transport and a second bolus or bubble of a fluid that is immiscible with the sample follows the sample. Many configurations are possible for the device of the invention. A preferred device includes: a substrate with a channel formed in its surface, and a cover element that overlies and seals the channel. Binding partner(s) are affixed to the surface of the cover element facing the channel lumen.
US07741103B2 Integrated screening and confirmation device
The present invention provides a fluid collection and drug testing device that includes a fluid collector, to collect a fluid sample, and a housing to test and retain the fluid sample. The housing includes a collection chamber, having an open end to receive the fluid collector, at least one membrane test strip, in fluid communication with the collection chamber, to indicate the presence or absence of at least one test drug, and an immunoassay-based fingerprint acquisition pad, in fluid communication with the collection chamber, to positively identify the test subject and associate the test subject with the fluid sample.
US07741095B2 Subtilases
The present invention relates to novel JP170 like subtilases from wild-type bacteria, hybrids thereof and to methods of construction and production of these proteases. Further, the present invention relates to use of the claimed subtilases in detergents, such as a laundry or an automatic dishwashing detergent.
US07741094B2 Protein having prolyl oligopeptidase activity, and composition containing the same
A protein of amino acid sequence SEQ ID NO:6 isolated from Coprinus clastophyllus. The protein is stable at 30 to 37 degrees centigrade and has an optimal prolyl oligopeptidase activity at about 45 degree centigrade and at about pH 7. The present invention also relates to a medicament comprising such protein for treating celiac disease caused by proline abundant gluten.
US07741093B2 Cellulases and their uses
The present invention provides novel cellulase fusion proteins, preparations of cellulase fusion proteins and compositions of cellulase fusion proteins. The present invention further provides cellulase expression vectors, host cells expressing cellulase and methods for preparing such vectors and cells. Uses of cellulases, cellulase preparations and cellulase compositions in the textile, detergent, pulp and paper industries are also provided.
US07741090B2 Glucose dehydrogenase and process for producing the dehydrogenase
A novel glucose dehydrogenase, which is an enzyme that has high substrate specificity, can be produced at a low cost, is not affected by oxygen dissolved in a measurement sample and, in particular, has superior thermal stability is obtained by culturing a microorganism belonging to the genus Burkhorderia and having glucose dehydrogenase producing ability in a medium and collecting glucose dehydrogenase from the medium and/or cells of the microorganism.
US07741089B2 Laccases, nucleic acids encoding them and methods for making and using them
The invention provides laccases, polynucleotides encoding these enzymes, the use of such polynucleotides and polypeptides. In one aspect, the invention relates to the enzymatic production of nootkatone by way of the conversion of valencene using proteins having a laccase activity, e.g., a novel laccase of the invention. In one aspect, the invention provides methods of depolymerizing lignin, e.g., in a pulp or paper manufacturing process, using a polypeptide of the invention. In another aspect, the invention provides methods for oxidizing products that can be mediators of laccase-catalyzed oxidation reactions, e.g., 2,2-azinobis-(3-ethylbenzthiazoline-6-sulfonate) (ABTS), 1-hydroxybenzotriazole (HBT), 2,2,6,6-tetramethylpiperidin-1-yloxy (TEMPO), dimethoxyphenol, and the like.
US07741087B2 Lipid remodeling of GPI-anchored proteins
This invention provides proteins and genes thereof involved in the GPI lipid remodeling process and, thereby and constructing a system for screening for useful substances such as anticancer agents and a system for detecting abnormalities in the GPI lipid remodeling process.
US07741082B2 Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor
A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2 with di-tert-butyl dicarbonate to form the BOC-protected amine.
US07741080B2 Adiponectin expression-inducing agents and uses thereof
The present invention provides adiponectin expression-inducing agents, and therapeutic agents using the same for obesity and obesity-related diseases such as cardiovascular diseases or metabolic diseases, as well as methods of searching for adiponectin expression-inducing agents.KLF9, which can bind to the 32-bp fragment of position −188 to position −157 from the adiponectin expression start site, was demonstrated to enhance adiponectin promoter activity. Therefore, the present invention uses KLF9 as an adiponectin expression-inducing agent, and suggests that KLF9 replenishment therapy is useful for preventing and/or treating obesity or obesity-related diseases including metabolic diseases such as insulin resistance and type II diabetes, and cardiovascular diseases.
US07741078B2 Heparin-binding protein modified with heparan sulfate sugar chains, process for producing the same and pharmaceutical compositions containing the same
A heparin-binding protein having covalently bonded heparan sulfate sugar chains within its molecule is produced by ligating a cDNA encoding a peptide which can be modified with heparan sulfate sugar chains selectively to a cDNA encoding a heparin-binding protein and producing in an animal cell the gene product of the resultant ligated cDNA. This heparan sulfate sugar chain-modified heparin-binding protein is functionalized by covalently bonding thereto glycosaminoglycan sugar chains containing little chondroitin sulfate. For example, this heparin-binding protein is excellent in stabilities, such as thermostability, acid resistance, alkali resistance and in vivo stability. Further, the heparan sulfate sugar chain-modified heparin-binding protein is effective in cell proliferation and tissue regeneration, and has effect of regulating the physiological functions of FGFs. Thus, this heparin-binding protein is extremely useful as a medicine for preventing or treating various FGF-related diseases.
US07741076B2 Production of the lipidated form of the peptidoglycan-associated lipoproteins of gram-negative bacteria
The expression of the lipidated form of the peptidoglycan-associated protein (PAL) of gram-negative bacteria is achieved through the use of a plasmid containing a tightly regulated promoter. A bacterial host cell is transformed, transduced or transfected with such a plasmid. The host cell is then cultured under conditions such that the lipidated recombinant PAL is expressed. The lipidated recombinant PAL is included in an antigenic composition administered to a mammalian host to immunize against a gram-negative bacterium.
US07741071B2 Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
US07741067B2 Luciferase-based assays
A method and kit is provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the luciferase with a tolerance enhancement agent in an amount sufficient to substantially protect luciferase enzyme activity from interference of the compound and minimize interference by at least about 10% relative to an assay not having tolerance enhancement agent.
US07741064B2 Materials and methods relating to G-protein coupled receptor oligomers
The invention provides materials and methods relating to G-protein coupled receptor (GPCR) oligomers. Complexes of two or more GPCRs associated with G-proteins are provided. Also provided are fusion proteins comprising a GPCR and a G-protein, nucleic acids, expression vectors and host cells. Methods of producing the complexes and fusion proteins of the invention are also provided.
US07741063B2 Toxoplasma gondii oocyst protein
Recombinant proteins have been developed for the detection of Toxoplasma gondii oocyst proteins for example in biological fluids. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of cells and the production of the proteins.
US07741059B2 Methods and compositions for detection of Ehrlichia chaffeensis (p120)
The invention provides methods and compositions for the detection of Ehrlichia chaffeensis.
US07741056B2 Use of A33 antigens and JAM-IT
The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.
US07741053B2 Processes for purification of recombinant proteins
Processes for the detection and purification of peptides and proteins comprising a metal ion-affinity peptide having a high affinity for coordinated metals and also being highly antigenic are described. Antibodies for use in the processes are also described.
US07741044B2 Libraries of oligomers labeled with different tags
A method of making a set of labelled compounds by the use of a preferably particulate support, comprises dividing the support into lots, performing a different chemical reaction on each lot of the support, e.g. to couple a chemical moiety to that lot of the support, tagging a fraction of each lot of the support with a different label, and combining the said lots of the support. The steps are repeated several times, preferably to build up oligomer molecules carrying labels which identify the nature and position of a monomer unit of the oligomer, and which are releasable from the support. Preferred labels, which are releasable from the compounds by cleavage to provide charged groups for analysis by mass spectrometry, are groups of the trityl (trimethylphenyl) family. Also claimed are libraries of these labels and their use in assays and nucleic acid analysis methods.
US07741041B2 Diagnostic analytical method utilizing DNA chips with thin-film transistor (TFT) elements
An IJ-system reagent inspection device 3 that instructs an ejection device to eject a reagent and reads an inspection result from a detachable DNA chip module 2. The method is carried out based on inspection information of inputted inspection items to produce and output inspection data along with inputted examinee-identification information and the corresponding inspection items through communication lines. In a control device 5, the examinee identification information is received from the IJ-system reagent inspection device 3 along with the inspection items and the inspection data through the communication lines. The inspection items and the inspection data are recorded in association with the examinee identification information to request a diagnosis based on the inspection data.
US07741040B2 Methods and compositions for detecting cancers
In certain aspects, the invention provides isolated SLC5A8 (also referred to as Hui1) nucleic acid molecules, which encode novel sodium solute symporter members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SLC5A8 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a SLC5A8 gene has been introduced or disrupted. The invention still further provides isolated SLC5A8 proteins, fusion proteins, antigenic peptides, and anti-SLC5A8 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. In other aspects, the invention provides methods and compositions for detecting and treating SLC5A8-associated cancer. Differential methylation of the SLC5A8 nucleotide sequences has been observed in SLC5A8-associated cancer, such as colon cancer, breast cancer, thyroid cancer, or stomach cancer.
US07741029B2 Diagnosis and treatment of blood disorders
Based on the discovery of the nucleotide and amino acid differences which distinguish the Gova and Govb allelic forms of the membrane glycoprotein CD109, and which comprise the biallelic Gov platelet alloantigen system, compositions and methods are provided for determining the Gov genotype and phenotype of individuals. Also provided, on the basis of this discovery, are compositions and methods for treating disorders associated with Gov alloantigen incompatibility, such as the bleeding disorders post-transfusion purpura, post-transfusion platelet refractoriness, and neonatal alloimmune thrombocytopenia. The two allelic forms of CD109 differ by a single amino acid. The Gova allelic form has Tyr at amino acid position 703 in the CD109 sequence. The Govb allelic form has Ser at the same position. This amino acid difference is due to a single change, from A for the Gova allele to C for the Govb allele, in the CD109 gene.
US07741024B2 Immunogenic proteoliposomes, and uses thereof
An immunogenic proteoliposome containing a transmembrane protein or oligomeric complexes containing such proteins, including viral envelope glycoproteins, in a lipid membrane around an elliptoid or spherical shape. The shape preferably also contains an attractant such as streptavidin or avidin and the lipid membrane contains a moiety that binds to the attractant such as biotin. The immunogenic transmembrane protein is bound to a ligand which is anchored in the shape. Methods for making the immunogenic proteoliposomes are provided. uses of the proteoliposome are described, including their use as immunogens to elicit immune reaction, and their use in screening assays, including their use as antigens to screen antibody libraries, as well as for drug screening and the identification of ligands.
US07741023B2 Method for predicting immune response to neoplastic disease based on mRNA expression profile in neoplastic cells and stimulated leukocytes
Tumor necrosis factor (TNF) is capable of inducing apoptosis by interacting with specific TNF receptors on the surface of cancer cells. Because multiple members of TNF ligand and receptor are present within each superfamily, over 300 different ligand-receptor combinations exist. Activated blood leukocytes produce TNF as part of the immune response to cancer, as well as producing chemokines to attract other leukocytes to the site. A method is disclosed of detecting significant induction of a variety of TNF superfamily subtype and chemokine mRNAs in blood leukocytes when whole blood is exposed to heat-aggregated IgG or anti-T cell receptor antibodies as a model of immune system interactions. Substantial individual-to-individual variation is observed in TNF subtypes and chemokines induced. Since peripheral blood leukocytes are the supply of anti-cancer immune cells, the quantitation of ex vivo inducibility of appropriate TNF ligands and chemokines in blood will be useful in individualized cancer immunotherapy. If the tumor mass is small, such as with early invisible metastatic lesions, appropriate TNF assaults may be sufficient to prevent relapse.
US07741020B2 Methods for detecting Lp-PLA2 activity and inhibition of Lp-PLA2 activity
This invention relates to methods for determining the activity of Lp-PLA2 in at least one sample from an animal. The invention also relates to methods for determining the inhibition of Lp-PLA2 activity in samples from animals that are administered an Lp-PLA2 inhibitor.
US07741011B2 Polymerizable composition and planographic printing plate precursor using the same, alkali-soluble polyurethane resin, and process for producing diol compound
A polyurethane resin is synthesized from a compound represented by the following Formula (1), a polymerizable composition includes the polyurethane resin, a planographic printing plate precursor includes a photosensitive layer including the composition, and a method produces a diol compound that can be used as a raw material of the polyurethane resin. In Formula (1), R1 and R2 each independently represent a single bond or an alkylene group optionally having a substituent, R3 represents a hydrogen atom or an alkyl group, R4 represents a hydrogen atom or an alkyl group, and A represents a divalent or higher linking group, provided that R1 and R2 are not both a single bond.
US07741010B2 Laser-decomposable resin composition and pattern-forming material using the same
A laser-decomposable resin composition, includes: (A) a polymer compound containing a structure represented by formula (0) as a repeating unit in a main chain of the polymer compound: wherein R1 represents H or a hydrocarbyl group which may have a substituent; and (B) a photo-latent or heat-latent catalyst, and a pattern-forming material, includes: a layer containing the laser-decomposable resin composition.
US07741009B2 Positive resist composition and method of forming resist pattern
A positive resist composition including a resin component (A) which exhibits increased solubility in an alkali developing solution under action of acid and has a structural unit (a1) represented by general formula (a1-0-2) shown below, and an acid-generator component (B) which generates acid upon exposure and includes an acid generator (B1) consisting of a compound represented by general formula (b1-12) shown below: wherein R represents a hydrogen atom, a lower alkyl group or a halogenated lower alkyl group; X2 represents an acid dissociable, dissolution inhibiting group; and Y2 represents an alkylene group or a divalent aliphatic cyclic group; and R2—O—Y1—SO3−A+  (b1-12) wherein R2 represents a monovalent aromatic organic group; Y1 represents an alkylene group of 1 to 4 carbon atoms which may be substituted with a fluorine atom; and A+ represents a cation.
US07741008B2 Positive resist composition, positive resist composition for thermal flow, and resist pattern forming method
Disclosed is a positive resist composition comprising a resin component (A) and an acid generator component (B), wherein the component (A) contains a polymer compound (A1) containing a structural unit (a0) represented by formula (a0) shown below and a structural unit (a2) derived from an acrylate ester containing a lactone-containing cyclic group: (wherein R represents a hydrogen atom, a halogen atom, a lower alkyl group, or a halogenated lower alkyl group; Y1 represents an aliphatic cyclic group; Z represents an acid dissociable, dissolution inhibiting group containing a tertiary alkyl group; a represents an integer from 1 to 3, b represents an integer from 0 to 2, and a+b=1 to 3; and c, d and e each represents, independently, an integer from 0 to 3).
US07741005B2 Planographic printing plate precursor and stack thereof
The present invention provides a planographic printing plate precursor, including: a support; and a photosensitive layer containing a polymerizable compound; an oxygen barrier layer; and a protective layer containing a filler (preferably an organic resin particle), the layers being formed in this order on the support. The present invention also provides a stack of planographic printing plate precursors, produced by stacking the planographic printing plate precursors with the photosensitive layer side outermost layer and the support side rear surface of the adjacent plate precursor in direct contact with each other.
US07741002B2 Toner, toner production method, and image forming method
The present invention provides a method for producing a toner including preparing an emulsified dispersion which contains emulsion particles by emulsifying or dispersing an oil phase containing at least a pigment and any one of a binder resin and a binder resin precursor in an aqueous medium, and granulating toner base particles by converging the emulsified dispersion, wherein the Casson yield value of the single oil phase before being emulsified or dispersed in the aqueous medium is 0.5 Pa to 20 Pa; and the temperature Tn of the emulsified dispersion in the preparation of the emulsified dispersion, the temperature Ts of the emulsified dispersion in the granulation of the toner base particles, and the glass transition temperature Tg of the toner base particles satisfy the relation Tn
US07741001B2 Toner for electrostatic image development and process for preparing the same
A process for preparing a toner for electrostatic image development, the process comprising the steps of:(S1) mixing an aqueous pigment dispersion and an aqueous resin particle dispersion containing self-dispersible polyester resin particles as a binder resin to prepare a mixture; and(S2) adding a polyvalent metal salt as a flocculant to the mixture while stirring to form aggregates of the pigment bonded to the resin particles,wherein the self-dispersible polyester resin is prepared by reacting a carboxylic acid compound with an alcohol compound inclusive of a polyhydric alcohol, the carboxylic acid compound being one or more of a polycarboxylic acid having three or more carboxyl groups and its anhydride.
US07741000B2 Image forming method
Disclosed is a method for forming color image, in which one of the yellow, magenta, cyan and black toners is a high water content toner, and one of the yellow, magenta, cyan and black toners is a toner low water content toner,water content of the high water content toner is 1.2 to 2.5% by weight based on the high water content toner, and water content of the low water content toner is 0.1 to 1.2% by weight based on the low water content toner.
US07740999B2 Toner
To achieve improvements in developing performance, transferring performance, and fixing performance, a toner has a glass transition temperature (TgA) of 40 to 60° C. and a temperature (P1) of the highest peak of 70 to 120° C.; cyclohexane (CHX) insoluble matter in the tetrahydrofuran (THF) soluble matter of the toner has a glass transition temperature (TgB) of 80 to 120° C.; TgA and TgB satisfy a specific formula; the toner has a viscosity at 100° C. of 5,000 to 30,000 Pa·s; and the cyclohexane (CHX) insoluble matter has an acid value of 5 to 40 mgKOH/g.
US07740991B2 Beam dose computing method and writing method and record carrier body and writing apparatus for determining an optimal dose of a charged particle beam
A beam dose computing method includes specifying a matrix of rows and columns of regions as divided from a surface area of a target object to include first, second and third regions of different sizes, the third regions being less in size than the first and second regions, determining first corrected doses of a charged particle beam for correcting fogging effects in the first regions, determining corrected size values for correcting pattern line width deviations occurring due to loading effects in the second regions, using said corrected size values in said second regions to create a map of base doses of the beam in respective ones of said second regions, using said corrected size values to prepare a map of proximity effect correction coefficients in respective ones of said second regions, using the maps to determine second corrected doses of said beam for correction of proximity effects in said third regions, and using the first and second corrected doses to determine an actual beam dose at each position on the surface of said object.
US07740987B2 Fuel cell cogeneration system, method of operating
A method of operating a fuel cell cogeneration system comprises the steps of cooling a fuel cell by circulating an internal heat transfer medium through the fuel cell while the fuel cell is generating electric power, storing an external heat transfer medium in a heat utilization portion, detecting remaining calories of the heat utilization portion by a first detector provided at the heat utilization portion, increasing a temperature of the fuel cell to an operating temperature by carrying out a first temperature increasing operation, and increasing the temperature of the fuel cell to the operating temperature by carrying out a second temperature increasing operation.
US07740982B2 Active material, manufacturing method thereof, and non-aqueous electrolyte secondary battery including the active material
A resistivity of an active material is reduced to drastically decrease an amount of a conductive auxiliary agent to be added, in order to provide a non-aqueous electrolyte secondary battery with high capacity. A material represented by a composition formula: LixMeOyNz, wherein 0≦x≦2, 0.1
US07740979B2 Alkaline electrochemical cell capable of providing optimum discharge efficiencies at a high tech drain rate and a low drain rate
An alkaline electrochemical cell capable of providing optimum discharge efficiencies at both a high tech drain rate and a low drain rate is disclosed. In one embodiment, the ratio of the anode's electrochemical capacity to the cathode's electrochemical capacity is between 1.33:1 and 1.40:1 and the surface area of the anode to cathode interface is maximized.
US07740978B2 Battery pack
The battery pack uses a restraining tool capable of secure restraint despite relatively low rigidity to achieve weight and cost reductions. The battery pack is formed of a plurality of parallel arranged battery modules (2), each consisting of a plurality of cells (5) electrically connected in series and coupled together in one piece with gaps (8) formed therebetween (5, 5), each cell being formed of elements for electromotive force encased in a prismatic case. The restraining tool includes connecting members (4) extending through the gaps (8) at both ends of the parallel arranged battery modules (2) and between two given cells (5, 5).
US07740975B2 Platinum and titanium containing electrocatalysts
The present teachings are directed toward electrocatalyst compositions of platinum, titanium and at least a third metal for use in fuel cells. The electrocatalyst composition is composed essentially of platinum present in an atomic percentage ranging between about 55 percent and about 85 percent, titanium present in an atomic percentage ranging between about 1 percent and about 30 percent, and at least a third metal present in an atomic percentage ranging between about 1 percent and about 30 percent. The third metal can be at least one member selected from the group consisting of nickel, vanadium and molybdenum.
US07740969B2 Separator for fuel battery
To provide a separator for a fuel battery in which a gasket is integrally formed with rubber in gasket forming grooves provided in a separator main body without the gasket forming grooves being damaged at a time of forming with the rubber and sealing performance being lowered due to the damage of the separator, the separator for the fuel battery is structured such that a groove width of the gasket forming groove formed in one surface of the separator main body is made larger than a groove width of the gasket forming groove formed in the other surface, or groove side surfaces in the gasket forming groove are formed in an inclined shape, or a curvature is provided in corner portions of a groove bottom surface.
US07740963B2 Liquid fuel type fuel cell system and its operating method
A direct methanol type fuel cell system provided with a tank for storing an antifreeze that is injected into at least said unit cell or a cell stack and held in place at the time of stand-by operation of the direct methanol type fuel cell system. At the time of starting operation an oxidant gas is supplied to the cathode side and the antifreeze is removed from the unit cell or the cell stack. After starting operation, the passage between the antifreeze tank and the unit cell or the cell stack is closed and an aqueous solution of methanol is supplied as liquid fuel from a fuel tank to the anode side.
US07740962B2 Compact fuel cell stack with current shunt
A fuel cell assembly includes first and second compression members. Two or more membrane electrode assembly (MEA) stacks are disposed between the compression members, each MEA stack having a positive and negative end. A first current collector is electrically coupled to a positive end of a first stack of the MEA stacks. A second current collector is electrically coupled to a negative end of a second stack of the MEA stacks. A current shunt is disposed between the compression members and electrically couples the MEA stacks.
US07740961B2 Magnetic recording medium
A magnetic recording media has recording cells formed of two-dimensionally arrayed magnetic material, a nonmagnetic layer surrounding the recording cells, an adhesive film formed on each of the recording cells, and a lubricant directly adhered to the adhesive film.
US07740960B1 Multifunctionally graded environmental barrier coatings for silicon-base ceramic components
A multilayered coating system consisting of a multicomponent zirconia-base or hafnia-base oxide top layer, an interlayer comprised of a plurality of sublayers and a bond coat layer is provided. The multilayered coating system of the present invention, with an interlayer comprised of a plurality of sublayers, provides a protective coating solution for silicon-base ceramic components exposed to very high temperatures and/or high gas flow velocity water vapor combustion environments. The plurality of sublayers affords for a multitude of interfaces that aid in phonon scattering within the coating system and thereby reduces its thermal conductivity. Furthermore, the plurality of interlayer sublayers afford a strain tolerant buffer between the top layer and substrate and thereby accommodate the thermal expansion mismatch between the oxide top layer (coefficient of thermal expansion (CTE) up to ˜8-10×10−6 m/m-C) and the silicon-base ceramic substrate (CTE≈4-5×10−6 m/m-C).
US07740959B2 Organic electroluminescent device
An organic electroluminescent device comprises: a pair of electrodes; and at least one organic layer comprising a light-emitting layer, said at least one organic layer being between the electrodes, wherein at least one of said at least one organic layer comprises at least one kind of compound represented by formula [1]: wherein Q101 represents a linking group, the bond between the carbon atom bonded by R107 and the carbon atom bonded by R108 may be a single bond or a double bond (provided that when the bond between the carbon atom bonded by R107 and the carbon atom bonded by R108 is a double bond, R106 and R109 are not present), R102 to R105 each represents a substituent, R106 to R109 each represents a hydrogen atom or a substituent, R107 and R108 may combine to form a condensed ring, and n101 represents an integer of 1 or more].
US07740958B2 Organic light-emitting device
Provided is an organic light-emitting device capable of emitting light with high efficiency by incorporating a silyl compound in which a silyl group and an amino group are directly bonded to an anthracene ring particularly into its light-emitting layer. In the organic light-emitting device including: a pair of electrodes composed of an anode and a cathode; and an organic compound layer interposed between the pair of electrodes, wherein the organic compound layer contains the following silyl compound. A layer containing at least one kind of the silyl compound is a light-emitting layer.
US07740957B2 Red phosphorescence compounds and organic electroluminescence device using the same
Red phosphorescence compounds and organic electro-luminescence device using the same are disclosed. In an organic electroluminescence device including an anode, a hole injecting layer, a hole transport layer, a light emitting layer, an electron transport layer, an electron injecting layer, and a cathode serially deposited on one another, the organic electroluminescence device may use a compound as a dopant of the light emitting layer.
US07740954B2 Reactive dendrimers
A process for modifying at least one dendron that is intended to form part of a dendrimer is disclosed. One reacts at least one reactable unsaturated group in a chemoselective manner to form a less unsaturated group. Also disclosed is a process for modifying dendrimers in a similar manner.
US07740953B2 Skin system with elastic components having differing hardnesses for use with robotics
An artificial skin system for use with a robotic assembly such as to provide an animated robot head with realistic skin movement. The skin system includes a receiving component for contacting the manipulator mechanism of the robotic assembly and also includes an exterior skin component that extends over the receiving component. An inner surface of the exterior skin component is integrally bonded to the receiving component such that the exterior skin component moves with the receiving component when a manipulator mechanism or robotics anchored to the receiving component moves or applies a force. The exterior skin component is formed of an elastic material with a second hardness that differs from a first hardness of elastic material of the receiving component, e.g., is less than the first hardness. The skin system includes a backing component bonded to the other components with a third hardness less than the first and second hardnesses.
US07740951B2 Multilayered polymeric structure and methods
Multilayered structures formed from two or more polymeric layers are fabricated to obtain a single structure preferably having advantages of each of the separate layers. Polyolefin-based substrates can provide a layer with a good balance of stiffness and impact resistance, excellent processability, and relatively lower cost. Tie layers, preferably physically positioned adjacent a polyolefin-based substrate layer, facilitates adhering additional layer(s) together with the polyolefin-based substrate. Suitable tie layers generally include a multicomponent blend of at least one vinyl cyanide-containing component and at least one styrenic block copolymer component. Preferably, the additional layers include at least one acrylate-based cap layer, which can have a glossy, scratch resistance outer layer with excellent optical characteristics.
US07740950B2 Composition suitable for single-sided, low-noise, stretch cling film and films made therefrom
The invention is directed to a composition suitable for use in a single-sided stretch cling film, the composition having from 0.1 to 20 percent by weight of a propylene-based copolymer having substantially isotactic propylene sequences, and having from 80 to 99 percent by weight of an ethylene-based copolymer having a density of at least 0.905 g/cc, wherein a film made from the composition exhibits cling layer to release layer cling of at least 70 grams force per inch as measured by ASTM D-5458-95, noise levels of less than 87 dB during unwinding operations, and has a modulus of at least 3 MPA as determined by ASTM D-882.
US07740939B2 Insulating magnetic metal particles and method for manufacturing insulating magnetic material
An insulating magnetic metal particle includes a magnetic metal particle containing at least one metal selected from the group consisting of Co, Fe, and Ni and having a diameter of 5 to 500 nm, a first inorganic insulating layer made of an oxide that covers the surface of the magnetic metal particle, and a second inorganic insulating layer made of an oxide that produces a eutectic crystal by reacting together with the first inorganic insulating layer at the time of heating them, the second inorganic insulating layer being coated on the first inorganic insulating layer. A thickness ratio of the second inorganic insulating layer with respect to the first inorganic insulating layer is set so that the first inorganic insulating layer remains on the surface of the magnetic metal particle after producing the eutectic crystal.
US07740937B1 Fiber having increased filament separation and method of making same
A flock material exhibiting an increased degree of filament separation prepared by cutting a fluoropolymer or carbon fiber yarn into lengths, introducing mechanical energy into the lengths in order to cause the lengths to separate into single-filaments fibers and removing or classifying at least a portion of the single-filament fibers from the lengths in order to obtain a flock having a particular fraction of single-filament, fluoropolymer or carbon fibers.
US07740933B2 Patterned, high surface area substrate with hydrophilic/hydrophobic contrast, and method of use
Nanoporous structures are constructed that have hydrophilic regions separated by hydrophobic regions. The porous, hydrophilic regions have reaction sites suitable for use in a bioassay application and have a higher density of reaction sites than that of a non-porous (2-D) surface. The structure may be made by depositing a layer of a matrix material (e.g., an organosilicate) and a porogen, and then crosslinking the matrix material to form a nanohybrid composite structure. The porogen is decomposed to form pores within the matrix material, and a reactive gas phase species (e.g., ozone) is patternwise directed onto a surface of the matrix material. Ultraviolet light (directed through a mask) activates the gas phase species to form a reactive species that then reacts with the matrix material to make it hydrophilic. The porogen may be decomposed thermally or by exposing it to an oxidizing atmosphere in the presence of ultraviolet light.
US07740931B2 Fire protection gate and correlated fire protection inset
At a fire protection gate with an encompassing structure and bilateral steel plate shells, between which a fire protection inset is provided, consisting of at least an insulating element in the form of a plate of mineral fibers, soluble in a physical milieu and reinforced with a binding agent, the composition of the mineral fibers of said insulating element features an alkali/earth alkali-mass relation of <1 and the fiber structure of said insulating element is determined by an average geometrical fiber diameter of ≦4 μm, a gross density in the range of 60 to 130 kg/m3 and a portion of the binding agent, relative to the fiber mass, in the range of 1 to 3 weight %.
US07740927B2 Container seal with integral promotional token and method
A container seal having a releasable, integral promotional token attached thereto comprises a sealing sheet bound to a promotional token by a releasable adhesive. The sealant sheet has a tacking surface and a sealing surface. The promotional token has a tacking surface and an obverse surface. At least one surface of the promotional token has promotional indicia visible thereon. The tacking surface of the promotional token is bound to the tacking surface of the sealant sheet by a releasable adhesive, so that the promotional token is peelably removable from the sealant sheet when the sealant sheet is bound to the finish of a container. In a preferred embodiment, the obverse surface of the promotional token is bound to a compressible liner by a second layer of releasable adhesive, the liner being separable from the promotional token without separating the promotional token from the sealing sheet. Preferably, the promotional indicia are in the form of a redeemable coupon, a proof-of-purchase indicator, or a game token.
US07740924B2 Labeled resin container
Disclosed is an in-mold labeled thermoplastic resin container specifically so designed that the ratio of the product A of the Gurley stiffness (m·kgf) and the 3% elongation load (kgf) of the label-edge part of the labeled area thereof to the product B of the Gurley stiffness and the 3% elongation load of the label-surrounding part of the non-labeled area thereof, A/B, is at most 0.6. The container has good drop impact fracture resistance and has good producibility, and it is lightweight.
US07740920B2 Chemically-bonded porous coatings that enhance humid fastness and fade fastness performance of ink jet images
Silica-based, chemically-bonded porous coatings, synthesized via the reaction of organo silanes with silica, are used as coatings for inkjet image printing. Silica is used as the base material in all cases, due to its favorable chemical properties of the surface, and the favorable pore structure. The silane-silica reaction product substantially retains the original pore structure of the pre-reacted silica. The disclosed embodiments solve the problems in the prior art in that any catalytic activity of the silica surface towards image fade is eliminated by the chemical modification of silica. This improves the image fade and humid fastness properties of the coating.
US07740919B2 Cellulose ester film, its manufacturing method, optical retardation film, optical compensation sheet, elliptic polarizing plate, and image display
A manufacturing method of a cellulose ester film satisfying the relationships, Nx>Ny>Nz, and 0.8≦Rt/R0≦3.5, the method comprising casting a cellulose ester dope containing a solvent of a good solvent and a poor solvent on a support to form a web; peeling the web from the support; transporting the peeled web (step D0); holding the edges in the transverse direction of the web (step A); stretching the resulting web in the transverse direction while applying a tension; reducing the tension in the transverse direction of the web; and drying the stretched web, wherein the residual solvent content of the web is 5 to 90% by weight at the beginning in the step A, and the residual poor solvent content in the residual solvent content of the web is from 15 to 95% by weight at the terminal point in the Step D0.
US07740918B2 Liquid crystalline medium and liquid crystal display
A dielectrically positive liquid crystalline media comprising: a first dielectrically positive component, component A, comprising a dielectrically neutral compound of formula I wherein the parameters have the meanings defined herein; a second dielectrically positive component, component B, comprising one or more dielectrically positive compounds having a dielectric anisotropy of more than 3; and optionally a dielectrically neutral component, component C, comprising one or more dielectrically neutral compounds having a dielectric anisotropy in the range from −1.5 to 3, are suitable for use in liquid crystal displays, especially active matrix displays, and in particular TN and to IPS displays.
US07740917B2 Method for forming thin film and base and having thin film formed by such method
A method for forming a film comprising a first process and a second process, the first process comprising the steps of: supplying a discharge gas to a first discharge space where high frequency electric field A is generated at or near atmospheric pressure, whereby the discharge gas is excite; transferring energy of the excited discharge gas to a film forming gas, whereby the film forming gas is excited; and exposing a substrate to the film forming gas to form a film on the substrate, and the second process comprising the steps of: supplying a gas containing an oxidizing gas to a second discharge space where high frequency electric field B is generated at or near atmospheric pressure, whereby the gas containing the oxidizing gas is excite; and the film formed in the first process is exposed to the excited gas containing the oxidizing gas.
US07740911B2 Method of forming a multi-layer coating on automobile bodies without a primer bake
This invention relates to a method for forming a multi-layer coating, comprising sequentially applying a layer of primer coating composition, a layer of base coat composition, and a layer of clear coat composition on an automotive substrate in a wet-on-wet-on-wet manner, and simultaneously curing the applied three layers together in a single baking step. The primer surfacer comprises a film forming binder, a volatile organic liquid carrier, and pigment(s); and the binder contains about (a) 40 to 95% by weight of a caprolactone-modified highly branched acrylic polymer having a hydroxyl and/or carboxyl monomer content, all or part of which has been reacted with caprolactone, of about 1 to 65% by weight and a weight average molecular weight of about 10,000 to 150,000; and (b) 5 to 60% by weight of an aminoplast resin crosslinking agent. The composition is essentially free of crosslinked nonaqueous dispersion resin particles or crosslinked microgel resin particles or both. The resulting cured multi-layered coating has excellent aesthetic appearance, strike-in resistance, chipping resistance, sag resistance, and film build even when formed in a three wet layered application method.
US07740910B2 Method for epoxy application control overpresses
A method for placing a resin layer or shim on a frame member uses an overpress. The overpress has an inner surface with protruding nubs. The operator places a bead of liquid resin on the inner surface of the overpress, then clamps the overpress to the frame member. The clamps force the nubs of the overpress into contact with the frame member and allows the nubs to define a clearance between the overpress and the frame member. The liquid resin spreads throughout the clearance and cures. After the resin has cured, the overpress is removed from the frame member, leaving a layer of cured resin bound to the frame member. This layer is then machined to a desired thickness.
US07740901B2 Low temperature method of making a zinc oxide coated article and the coated article made thereby
An atmospheric chemical vapor deposition method of making a zinc oxide coated glass article, made by directing one or more streams of gaseous reactants, specifically a zinc containing compound, and an oxygen containing compound, onto a surface of a transparent substrate material heated to a temperature of 400° C. or less.
US07740896B2 Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof
The invention relates to a method for precipitating mono or multiple layers of organophosphoric acids of the general formula I (A) Y—B—OPO3H2  (IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2  (IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinimydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic indicator element may be coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring the substrate surface a resistance to protein adsorption and/or to cell adhesion and in the B chain may optionally be comprised one or more ethylene oxide groups, rather than one or more —CH2— groups. According to the invention, said precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, comprising the use of water-soluble salts of a compound of formula (IA) or (IB) for the treatment of these surfaces, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices in addition to new organophosphoric acids and organophosphonic acids themselves. The optionally substituted compounds of formulae (IA) and (IB) wherein the B and Y groups have the above-mentioned designations, i.e. optionally substituted alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetaryl, are hereinafter referred to as organophosphoric acids and organophosphonic acids.
US07740895B2 Nixtamalization process and products produced therefrom
The present invention provides a nixtamalization process wherein corn endosperm fractions, subfractions, or combinations thereof are individually nixtamalized to produce food products. The invention also comprises food products, including masa, instant masa, tortillas, and tortilla-related food products produced by the present invention's methods, including food products that have controllable fat and/or fiber levels.
US07740892B2 Coffee bean roaster and method for roasting coffee beans using the same
A coffee bean roaster and a method for roasting coffee beans using the roaster are disclosed. The coffee bean roaster includes an oven having a ceramic heating plate with a gate, and a rotary sliding unit to enter the gate so as to slide into the ceramic heating plate, so that the rotary sliding unit roasts coffee beans while rolling the coffee beans and spacing the coffee beans from both the ceramic heating plate and a burner. The method for roasting coffee beans using the coffee bean roaster includes entering the rotary sliding unit containing the coffee beans into the oven through the gate so as to place the rotary sliding unit in the oven at a position spaced apart from both the ceramic heating plate and the burner, roasting the coffee beans by far-infrared radiant heat emitted from the ceramic heating plate, and reburning combustion gases, generated from the roasting of the coffee beans, by the burner.
US07740891B2 Hand-held oatmeal
A hand-held oatmeal product is provided that is ready to eat. The oatmeal product may be packaged in a retortable pouch. Methods of making the oatmeal product are provided.
US07740884B2 Freeze-dried FSH/LH formulations
The invention relates to the field of pharmaceutical formulations of a mixture of follicle stimulating hormone (FSH) and luteinising hormone (LH), and to methods of producing such formulations.
US07740881B1 Method of treating humans with opioid formulations having extended controlled release
Solid controlled-release oral dosage forms comprising a therapeutically effective amount of an opioid analgesic or a salt thereof which provide an extended duration of pain relief of about 24 hours, have a dissolution rate in-vitro of the dosage form, when measured by the USP Paddle Method at 100 rpm at 900 ml aqueous buffer (pH between 1.6 and 7.2) at 37° C. of from about 12.5% to about 42.5% (by wt) opioid released after 1 hour, from about 25% to about 65% (by wt) opioid released after 2 hours, from about 45% to about 85% (by wt) opioid released after 4 hours, and greater than about 60% (by wt) opioid released after 8 hours, the in-vitro release rate being substantially independent of pH and chosen such that the peak plasma level of said opioid analgesic obtained in-vivo occurs from about 2 to about 8 hours after administration of the dosage form.
US07740877B2 Aliphatically modified biodegradable block copolymers as thermogelling polymers
A thermogelling, aliphatically modified polymer for use in drug delivery is described. Illustrative embodiments include poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) hexanoate and poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) laurate. Another illustrative embodiment includes a composition having a thermogelling amount of an aliphatically modified poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) and an effective amount of a drug. The thermogelling polymers are made by bonding an aliphatic group to poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone). A method of use includes injecting a warm-blooded individual with a thermogelling amount of the aliphatically modified polymer and a drug.
US07740876B2 Antimicrobial composition of 3-iodo-2-propynylbutyl carbamate and 1,3-butylene glycol as solvent
An antimicrobial composition of 3-iodo-2-propynylbutyl carbamate (IPBC) and 1,3-butylene glycol (BG) as solvent, in a defined weight ratio, preferably 9-11% IPBC and 89-91% BG, and personal care formulations including the composition in an amount of about 0.1-0.2% therein, at a pH of 4-9, is described.
US07740874B2 Method of making a lanolin free absorption base
A composition of matter comprises a lanolin free absorption base. The absorption base in includes a superior lanolin free emulsifier selected for its HLB (hydrophilic-lipophilic balance) compatibility, neutral, nonionic absorption base ideal for the incorporation of many active ingredients. Use of this emulsifier permits low production temperatures during base manufacture, thereby allowing incorporation of heat labile active ingredients. More efficient emulsification is realized, which leads to a much lower concentration of emulsifier. The absorption base is especially effective formulation for hydrocortisone or its salts due to HLB compatibility, and stabilizing ingredients often found in prior art products can be eliminated due to HLB compatibility.
US07740873B2 Composition comprising a quaternary silicone and a liquid fatty alcohol and method of treatment
Composition containing at least one silicone with quaternary ammonium groups and at least one liquid fatty alcohol. Method for the cosmetic treatment of keratinous materials, in particular hair. The compositions preferably are transparent and have a melting texture. Hair treated with these compositions is shiny, feels soft and is free of residues.
US07740870B2 Group B Streptococcus antigens and corresponding DNA fragments
The present invention relates to antigens, more particularly antigens of Group B Streptococcus (GBS) (S. agalactiae) which may be useful to prevent, diagnose and/or treat streptococcal infections.
US07740869B2 Phep, an amino acid permease of Staphylococcus aureus
The present invention relates to antigenic polypeptides expressed by pathogenic microbes, including antigenic polypeptides encoded by the nucleic acid sequence of FIG. 1, vaccines comprising the antigenic polypeptides and therapeutic antibodies directed to the antigenic polypeptides.
US07740868B2 Activatable clostridial toxins
Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
US07740867B2 Method for identification of virulence determinants
Disclosed are methods for the determination of virulence determinants in bacteria and in particular bacteria of the genus Mycobacterium. Also disclosed are compositions and methods for stimulating an immune response in an animal using bacteria and virulence determinants identified by the methods of the present invention.
US07740866B2 Circovirus sequences associated with piglet weight loss disease (PWD)
The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection is further provided. Pharmaceutical, including vaccines, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
US07740861B2 Drug delivery product and methods
The present invention provides a particulate delivery system comprising an extracted yeast cell wall comprising beta-glucan, a payload molecule and a payload trapping molecule. The invention further provides methods of making and methods of using the particulate delivery system.
US07740860B2 Composition and method for preventing or treating a virus infection
The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections.
US07740858B2 SARS-CoV-specific B-cell epitope and applications thereof
Disclosed is SARS-CoV-specific B-cell epitope and applications thereof. The epitopes are peptides and can either be expressed in phages or synthesized to diagnose SARS patients accurately. High sensitivity and specificity of the serologic detection are achievable by using a plurality of SARS-CoV-specific B-cell epitope-based peptides. Therefore, the peptides can be applied to SARS diagnosis and have potentials to be immunogens for producing antibodies against SARS.
US07740857B2 Compositions and methods for treating malaria with cupredoxin and cytochrome
The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the malaria parasite, and in particular the parasitemia of human red blood cells by P. falciparum. The invention provides isolated peptides that are variants, derivatives or structural equivalents of cupredoxins or cytochrome c, and compositions comprising cupredoxins and/or cytochrome c, or variants, derivatives or structural equivalents thereof, that are useful for treating or preventing malaria infection in mammals. Further, the invention provides methods to treat mammalian patients to prevent or inhibit the growth of malarial infection in mammals. The invention also provides methods to prevent the growth of malaria infection in insect vectors.
US07740854B2 Treatment of macrophage mediated disease
The invention relates to a method of treating or monitoring/diagnosing a disease state mediated by activated macrophages. The method comprises the step of administering to a patient suffering from a macrophage mediated disease state an effective amount of a composition comprising a conjugate or complex of the general formula Ab-X where the group Ab comprises a ligand capable of binding to activated macrophages, and when the conjugate is being used for treatment of the disease state, the group X comprises an immunogen, a cytotoxin, or a compound capable of altering macrophage function, and when the conjugate is being used for monitoring/diagnosing the disease state, X comprises an imaging agent. The method is useful for treating a patient suffering from a disease selected from the group consisting of rheumatoid arthritis, ulcerative colitis, Crohn's disease, inflammation, infections, osteomyelitis, atherosclerosis, organ transplant rejection, pulmonary fibrosis, sarcoidosis, and systemic sclerosis.
US07740851B2 Ultra high affinity neutralizing antibodies
Ultra high affinity antibodies with binding affinities in the range of 1010 M−1, and even 1011 M−1 are disclosed. Such antibodies include antibodies having novel high affinity complementarity determining regions (CDRs), especially those with framework and constant regions derived from either humans or mice. Methods of preparing and screening such antibodies, as well as methods of using them to prevent and/or treat disease, especially virus-induced diseases, are also disclosed.
US07740849B2 Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders
Disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using combinations of compounds that alter soluble endoglin and sFlt-1 expression levels or biological activity. Also disclosed are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using compounds that increase endothelial nitric oxide synthase levels or biological activity.
US07740845B2 Uses of monoclonal antibody 8H9
This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides different uses of the monoclonal antibody 8H9 or its derivative.
US07740839B2 EC SOD and cell transducing EC SOD and use thereof
The present invention relates to an EC SOD, a cell-transducing EC SOLD, and the use thereof. More particularly, the present invention relates to an EC SOD, an EC SOD fusion protein enhanced Cell-transduction ability, and the use thereof for preventing or treating skin diseases.
US07740837B2 Genetically modified cells expressing a TGF beta inhibitor, the cells being lung cancer cells
The present invention relates to compositions comprising a therapeutically effective amount of genetically modified cells containing a genetic construct expressing a TGFβ inhibitor effective to reduce expression of TGFβ, where the genetically modified cells are non-small cell lung cancer (NSCLC) cells or small cell lung cancer (SCLC) cells, and related methods.
US07740834B2 Murine zcytor17 ligand polypeptides
The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
US07740824B2 Optical quality diamond material
A CVD single crystal diamond material suitable for use in, or as, an optical device or element. It is suitable for use in a wide range of optical applications such as, for example, optical windows, laser windows, optical reflectors, optical refractors and gratings, and etalons. The CVD diamond material is produced by a CVD method in the presence of a controlled low level of nitrogen to control the development of crystal defects and thus achieve a diamond material having key characteristics for optical applications.
US07740823B2 Method of growing III group nitride single crystal and III group nitride single crystal manufactured by using the same
A method of growing a III group nitride single crystal by using a metal-organic chemical vapor deposition (MOCVD) process, the method including: preparing an r-plane (1-102) substrate; forming a nitride-based nucleation layer on the substrate; and growing a nonpolar a-plane nitride gallium single crystal on the nitride-based nucleation layer while altering increase and decrease of a ratio of V/III group to alternate a horizontal growth mode and a vertical growth mode.
US07740821B2 Highly condensed mesoporous silicate compositions and methods
A mesoporous silicate is prepared by a method that includes combining a silicate precursor, a bifunctional catalyst, and a structure-directing surfactant in an aqueous medium having a pH of about 4 to about 10. A mesoporous silicate forms as an aqueous suspension and can then be isolated. The mesoporous silicate can be formed under mild conditions of temperature and pH, and it exhibits a surprisingly high degree of network condensation.
US07740820B2 Method of producing fluoroapatite, fluoroapatite, and adsorption apparatus
A method of producing a fluoroapatite is provided. The method comprises preparing a slurry containing a hydroxyapatite which has at least one hydroxyl group, preparing a hydrogen fluoride-containing solution containing a hydrogen fluoride, mixing the hydrogen fluoride-containing solution with the slurry to obtain a mixture to thereby adjust a pH of the mixture in the range of 2.5 to 5, and reacting the hydroxyapatite with the hydrogen fluoride in the mixture in a state that the pH of the mixture is adjusted within the above range to thereby obtain the fluoroapatite by substituting the at least one hydroxyl group of the hydroxyapatite with fluorine atom of the hydrogen fluoride. The method can produce the fluoroapatite having improved acid resistance by reducing an impurity, such as ammonia, derived from a raw material to a low or very low level. Further, a fluoroapatite having high acid resistance is also provided. Furthermore, an adsorption apparatus using such a fluoroapatite is provided.
US07740818B2 Transition metal-substituted hydrotalcite catalyst for removing nitrogen oxides from the exhaust gas of diesel engine by storage-reduction
Disclosed herein is a transition metal-substituted hydrotalcite catalyst for removing nitrogen oxides using a storage-reduction method, in which a molar ratio of transition metal to magnesium is 0.2 or less, and a method of manufacturing a transition metal-substituted hydrotalcite catalyst for removing nitrogen oxides using a storage-reduction method, including the steps of preparing a hydrotalcite synthesis solution including transition metal precursors such that the molar ratio of transition metal to magnesium is 0.2 or less, and preferably 0.001 to 0.2; aging the synthesis solution; and hydrothermally treating the synthesis solution.
US07740816B1 Method for treating gases to be scrubbed
A method for treating gases to be scrubbed, comprising filling a scrubber with a volume of lean liquid adequate to cover a sintered permeable membrane in the reaction chamber and a bit more to create a reaction zone in not only a plurality of pores in the membrane with gases but in a reaction zone above the membrane, then introducing gases to be scrubbed to the membrane, building up pressure in the reaction chamber, and passing scrubbed gas from the reaction zone to an exit port at a rate equal to the rate of gases to be scrubbed are introduced.
US07740805B2 Integrated CMOS-compatible biochip
A device for analyzing a fluid sample is provided. The device includes a substrate, a trench formed in said substrate, and a processor. The trench includes a channel, a sample chamber, and a reagent chamber, each in fluid communication with each another. The sample chamber is configured to receive the fluid sample. The processor is integrally formed in the substrate and is in communication with the trench. The processor is configured to analyze the fluid sample. Methods for manufacturing the device are also provided.
US07740803B2 Biochemical sensor with thermoelastic probes
The thermoelastic response of certain materials to an incident electromagnetic excitation beam is highly sensitive to physical conditions existing at the surface of the material. Probe structures carrying probe materials are used as sensors in the analysis and investigation of biochemical molecules. Each probe structure is adapted to undergo a thermoelastic response when excited by temporally varying electromagnetic radiation, characteristics of the thermoelastic response being a function of physical properties of material binding to the surface of the probe structure. An electromagnetic excitation means directs electromagnetic energy at a selected one of the probe structures in order to elicit the excitation response. A detection means determines change in excitation response of the probe structures resulting from the binding of molecules thereto.
US07740789B2 Method for eliminating detrimental effects of flash on cups used for sport stacking
A method of making a cup that decreases the amount of flash on a bottom surface of the cup is provided. More specifically, a cup is provided that includes a thickened lip around an open surface. The lip also includes a recess for the receipt of excess material generated by the molding process. This excess material, or flashing, is detrimental to the use of cups in cup stacking competitions.
US07740788B2 Method of correcting shape of green tire and apparatus for carrying out the same
The shapes of the upper tire bead Bu and the lower tire bead Bl of a green tire G and the axial distance between the tire beads Bu and Bl are corrected in a short work time. The green tire G is placed in horizontal attitude on a green tire support table 3 provided with a lower tire bead correcting unit 10. Radially movable pressing members 13 included in the lower tire bead correcting unit 10 are engaged with the inner side of the lower tire bead Bl of the green tire G and stoppers 29 of the upper tire bead correcting unit 20 are engaged with the inner side of the upper tire bead Bu of the green tire G placed on the green tire support table 3. The pressing members 13 of the lower tire bead correcting unit 10 are moved radially outward to shape the lower tire bead Bl into a completely round shape of a predetermined diameter. The stoppers 29 of the upper tire bead correcting unit 20 are moved radially outward to shape the upper tire bead Bu into a completely round shape of a predetermined diameter and, at substantially the same time, the upper tire bead correcting unit 20 or the lower tire bead correcting unit 10 is moved vertically to adjust the axial distance B between the tire beads Bu and Bl to a predetermined axial bead spacing.
US07740786B2 Process for making necked nonwoven webs having improved cross-directional uniformity
Necked nonwoven webs having improved cross-directional uniformity are made by a process which includes the step (prior to neck stretching) of corrugating the nonwoven web to reduce its width from an initial width A to a reduced corrugated width B. The cross-directional uniformity is optimized as the corrugated width B approaches the ultimate width C of the necked nonwoven web.
US07740783B2 Film forming mold, film forming method using mold, and film forming control system
When forming a film on a work, such as a lamp holder, the work is not set in a film-forming chamber as in the prior art, but a film is formed thereon by using a mold, thereby simplifying the film formation work. A movable mold is matched to a fixed mold in a state where a vacuum deposition apparatus, the film-forming element, is provided in the fixed mold and the work is supported in the movable mold. Next, film formation is carried out with the film-forming space in a vacuum state. Thereafter, the movable mold is opened, wherein the film formation work on the work surface using molds can be carried out with a series of processes.
US07740779B2 Multiple calender process for forming non-fibrous high modulus ultra high molecular weight polyethylene tape
A multi-calender process for forming a high modulus, high strength component for use in ballistic-resistant articles. The process includes forming ultrahigh molecular weight polyethylene powder into a uniform sheet at a low pressure. Multiple calender units mold and draw the uniform sheet into a non-fibrous, monolithic, ultra high molecular weight polyethylene tape. The multi-calender process and subsequent draw stages stretch the non-fibrous UHMWPE tape to a total draw of at least 100 to 1 to produce a high modulus, high strength UHMWPE component with a modulus of 1,400 grams per denier or greater. The multi-calender process of the present invention enables production of a high-strength, high-modulus UHMWPE component for ballistic-resistant articles and other applications at significantly higher rates and at a lower unit cost.
US07740778B2 Conductive belt, method of producing same, and image-forming apparatus having same
A method of producing a conductive belt composed of a base resin containing polybutylene naphthalate resin at not less than 50 mass % nor more than 100 mass % and 1 to 3 mass % of carbon nano-fibers having a DBP oil absorption amount at not less than 150 ml/100 g. The method includes the steps of forming a conductive master batch by mixing the carbon nano-fibers with resin for use in a master batch containing the polybutylene naphthalate resin; mixing the obtained conductive master batch and resin for blending use containing the polybutylene naphthalate resin and not containing the carbon nano-fibers with each other in an unmelted state by setting a mixing mass ratio of the conductive master batch smaller than that of the resin for blending use; and meltingly molding an obtained mixture by an extrusion molder.
US07740777B2 Method and apparatus for producing polymer fibers and fabrics including multiple polymer components
A spunbond system for manufacturing a non-woven web of fibers includes a spin beam assembly configured to process and deliver a plurality of polymer streams for extrusion through spinneret orifices. The spin beam assembly includes a plurality of manifold sections within the spin beam assembly, each manifold section including a distribution pipe configured to transfer a respective polymer component to a plurality of piping sections extending within the manifold section and a heat transfer medium that flows within the manifold section and around the piping sections extending into the manifold section so as to maintain the respective polymer component at a selected temperature. The system further includes a quenching zone configured to receive and quench extruded filaments from the spinneret orifices, a drawing unit in communication with the quenching zone and configured to receive and attenuate the quenched filaments, and a forming surface configured to receive drawn filaments emerging from the drawing unit and form a non-woven fibrous web on the forming surface.
US07740773B2 Conductive composition and conductive paste
The present invention provides a conductive composition and a conductive paste from which a conductive film having a high conductivity and a low thermal expansion coefficient can be formed.The thermal expansion coefficient of an island fixing type conductive layer 10 is compatible with that of a substrate 12. A cracking of the island fixing type conductive layer 10 or a crack in the substrate 12 due to a difference between these thermal expansion coefficients is suitably inhibited. The thermal expansion coefficient of the island fixing type conductive layer 10 is adjusted by ZWP contained in the range from 10 to 55 (wt %) as a low-expansion filler. Thus, compared with the case where other low-expansion filler is added, the conductivity degradation is inhibited. Accordingly, the island fixing type conductive layer 10 having a high conductivity and a high bonding strength is obtained.
US07740771B2 Methods of determining a composition ratio of an organic white-light-emitting blend material
Organic white-light-emitting blend materials were prepared by light-doping method and electroluminescent devices fabricated using the same, including a transparent substance, translucent electrode, white-light-emitting layer and metal electrode in order, can efficiently control Förster energy transfer in organic light-emitting materials by performing light doping, thus to fabricate a white electroluminescent device using the blend materials which can emit white-light with high efficiency. The white-light-emitting blend materials can be obtained by the light-doping method, in which the energy transfer occurs only between a host which is a donor and each dopant which is an acceptor, while the energy transfers between dopants are efficiently blocked.
US07740768B1 Simultaneous front side ash and backside clean
A method and apparatus for cleaning a wafer. The wafer is heated and moved to a processing station within the apparatus that has a platen either permanently in a platen down position or is transferable from a platen up position to the platen down position. The wafer is positioned over the platen so as not to contact the platen and provide a gap between the platen and wafer. The gap may be generated by positioning the platen in a platen down position. A plasma flows into the gap to enable the simultaneous removal of material from the wafer front side, backside and edges. The apparatus may include a single processing station having the gap residing therein, or the apparatus may include a plurality of processing stations, each capable of forming the gap therein for simultaneously removing additional material from the wafer front side, backside and edges.
US07740767B2 Method and apparatus for manufacturing patterned media
According to one embodiment, a method for manufacturing a patterned media includes forming patterns of a magnetic layer having protrusions and recesses corresponding to tracks, servo zones or data zones on a substrate having a center hole, and spraying gas flow produced by diffusing a liquid gas toward the center hole of the substrate before or after forming the patterns of the magnetic layer.
US07740765B2 Methods for treating water
Disclosed is a method of providing potable water that includes providing a filter, passing water through the filter, and removing bacteria and viruses from the water with the filter. The filter comprises a housing having an inlet and an outlet and a filter material disposed within the housing, the filter material formed at least in part from a plurality of filter particles consisting of mesoporous activated carbon. A sum of mesopore and macropore volumes of the filter particles may be between about 0.2 mL/g and about 2 mL/g, wherein mesopore means an intra-particle pore having a diameter between 2 nm and 50 nm, and macropore means an intra-particle pore having a diameter greater than 50 nm, a total pore volume of the filter particles is greater than about 0.4 mL/g and less than about 3 mL/g, and a ratio of the sum of the mesopore and macropore volumes to the total pore volume of the filter particles is greater than about 0.3. The filter removes bacteria and viruses from the water at a level of Filter Bacteria Log Removal of greater than about 2 logs and a Filter Viruses Log Removal of greater than about 1 log.
US07740762B2 Treatment of sewage sludges
The present invention provides a method of reducing the pathogen content of sewage sludge comprising (a) adding to the sludge an effective amount of a phosphorous-containing compound and (b) keeping the phosphorous-containing compound in contact with the sludge for a sufficient time to reduce the amount of pathogens present in the sludge by an amount equivalent to a logarithmic reduction of 2 or more.
US07740760B2 Fluid concentrator
A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.
US07740759B2 Magnetic separation device
A magnetic separation device separating magnetic material from a working fluid of a container is disclosed. The magnetic separation device includes a first element, a second element and a magnetic assembly structure including a plurality of magnetic units. The first element includes a first body, a plurality of first main positioning portions disposed on the first body, and a plurality of first sub-positioning portions disposed on the first body and next to the first main positioning portions to receive the container. The second element includes a second body, a plurality of second main positioning portions disposed on the second body, and a plurality of second sub-positioning portions disposed on the second body and next to the second main positioning portions to receive the container. The magnetic units disposed on the first main positioning portions and the second main positioning portions absorb magnetic material from the working fluid.
US07740757B2 Apparatus for removing buoyant pollutants
An exemplary apparatus (20), for removing pollutants atop a body of coolant, includes a filter (21), a pollutant removing structure (22), and a pump (23). The filter includes a housing (210), and a filtering unit (211) positioned in the housing for removing the pollutants from the coolant. The filtering unit is separated into a first cavity (2112) and a second cavity (2113) by a partition sheet (213). The partition sheet is spaced apart from a bottom surface of the housing to define a communicating gap (2131) for the first cavity and the second cavity to communicate with each other. The pollutant removing structure is positioned on the filter. The pollutant removing structure includes a removing member (221) for removing the pollutants out of the filter. The pump is configured for pumping the coolant into the first cavity of the filter.
US07740755B2 Foam insert for rain gutter
A foam insert for a rain gutter for a residential dwelling is provided. The foam insert prevents debris such as leaves, pine needles, gravel, and dirt from entering the rain gutter and permits water to pass through the foam and into the gutter. The foam insert has a channel in the outer side to receive the inwardly projecting lip of a gutter when the foam insert is placed into the gutter. As the foam inserts are installed in the gutter, the lip of the gutter is positioned within the channel. The foam is flexible, which permits the foam insert to be bent and maneuvered into position within the gutter. The foam inserts are formed with a pore size of 14 ppi or below. The foam inserts are inexpensive and may be quickly and easily installed or removed from the gutter by a single individual.
US07740754B2 Apparatus for purifying a liquid
An apparatus for purifying a liquid including: reaction chambers that utilizes an ionization reaction material in turbulence with the liquid, a first fine collective filtration unit, a first laser photolytic light chamber that utilizes ultraviolet light in the 100 to 300 nanometer range to irradiate liquid, a second ultra-fine collective filtration unit, and a pharmaceutical grade granular activated carbon filter unit.
US07740752B2 Fluid remediation system
A system for separating suspended and dissolved materials in a fluid having a pH offset from neutral is disclosed. It employs a plurality of stacked, generally flat treatment beds each having a surface angled downward for receiving the fluid. Since the fluid is spread over a large surface, its velocity slows causing suspended materials to drop out of the fluid as a sludge. A pH correction device may add an agent to the flowing fluid which will bring the pH closer to neutral thereby causing said dissolved materials to precipitate out and into the sludge. Atmospheric oxygen may also be used to effect the precipitation. Portions of the beds may be isolated and the sludge collected resulting in a fluid having substantially less suspended and dissolved materials at a pH and temperature closer to normal. Energy may be produced from the movement of liquid through the system or from the heat energy of the fluid. Magnetics may be utilized to improve the precipitation of solids. The effluent discharge outlet may be connected to polishing ponds and/or to a water treatment facility. This invention is especially useful for remediating acid mine drainage.
US07740747B2 Injection method for microfluidic chips
A microchip for capillary electrophoresis is provided. The microchip comprises an injection channel and a separation channel configured to receive a sample through a sample well disposed on a first end of the separation channel; wherein the injection channel and the separation channel intersect to form a ‘T’ junction. The microchip further comprises a first valve disposed adjacent to the ‘T’ junction and on the separation channel and a second valve disposed at the ‘T’ junction. The second valve is a two-way valve. A sample plug is injected into an area between the ‘T’ junction and a second end of the separation channel.
US07740742B2 Powder composition for paper manufacturing
The powder composition for paper manufacturing of the invention contains a hydrophobic organic compound (A), an emulsifying and dispersing agent (B), and optionally water-soluble saccharides (C) added based on necessity and has an average particle diameter of 0.1 to 2,000 μm.
US07740741B2 Para-aramid pulp including meta-aramid fibrids and processes of making same
The present invention relates to para-aramid pulp including meta-aramid fibrids for use as reinforcement material in products including for example friction materials, fluid sealing materials, and papers. The invention further relates to processes for making such pulp.
US07740737B2 Plasma processing apparatus and method
An apparatus includes an upper electrode and a lower electrode for supporting a wafer disposed opposite each other within a process chamber. A first RF power supply configured to apply a first RF power having a relatively higher frequency is connected to the upper electrode. A second RF power supply configured to apply a second RF power having a relatively lower frequency is connected to the lower electrode. A variable DC power supply is connected to the upper electrode. A process gas is supplied into the process chamber while any one of application voltage, application current, and application power from the variable DC power supply to the upper electrode is controlled, to generate plasma of the process gas so as to perform plasma etching.
US07740732B2 Method for producing disposable worn article
A method for producing a disposable worn article of the present invention is directed to a method for producing a worn article including a core portion 2 covering the crotch of the wearer, and a torso portion 3 that fits to the torso of the wearer, wherein the torso portion 3 includes a back portion 3L and a front portion 3S. The method includes: a step of carrying a first web W1 including a waist portion 31 of a first back portion 3L1 and a second web W2 including a waist portion 31 of a second back portion 3L2 in the longitudinal direction Y of the webs; a step of forming a combined member by placing the core portion 2 so as to bridge between the first and second webs W1 and W2; and a step of cutting the combined member so as to divide the combined member into a first group G1 and a second group G2.
US07740730B2 Method of closing a container with a lid
A lid for closing containers includes an at least two-layered composite assembly. A layer facing the container seals against a container edge and forms an opening by layer separation, for removing contents. The layers have a continuous construction without weakening lines. The layer facing the container is made mainly of a plastic having an intrinsic tearing resistance being lower in the region of the opening than its adhesion to the layer facing away from the container in a remaining region and an adhesion to the container edge being greater at least in the region of an opening aid than to the other layer. The plastic adheres so strongly to the outer layer in the region of the opening that a region corresponding to the opening is torn out upon opening and a remaining layer of the lid facing the container continues to adhere to the container edge by sealing action.
US07740729B1 Method and system for controlling the eccentricity of bonded multiple optical discs
Techniques for bonding two disks with a minimized eccentricity (ECC) are disclosed. A positioning header includes an ECC controlling structure that further includes a positioning header. In one embodiment, the position header includes three members that form a round stand with a diameter smaller than the inner diameter of the disks. The round stand expands to the inner diameter of the disks to close the gap as a result of the difference between the two diameters when the three members are caused to expand. In one embodiment, the movement of the three members is controlled by magnetic means. Depending on the positions of the ECC controlling structure, the three members are expanded from or restored to their default positions.
US07740728B2 Film separation method and film separation apparatus
A film separation apparatus (100) for separating a film (110) attached to a film application surface of a wafer (120) comprises a wafer adsorption unit (31) for adsorbing the wafer with the film application surface up, a release tape supply unit (42) for supplying the release tape (3) onto the film application surface, and a heating unit (80) for pressing and heating only a part of the release tape against the wafer film at an edge of the wafer. Thus, the adhesion between the release tape and the film is increased at the particular part of the release tape. The apparatus further comprises a peeling unit (44) for separating the film from the film application surface of the wafer using a release tape with a part of the release tape having an improved adhesion as a separation starting point. Thus, the surface protective film can be easily separated from the wafer.
US07740727B2 Elastic composite for a disposable absorbent garment, and a system and process for making the elastic composite and a garment having the elastic composite
A method is provided for making an elastic composite for incorporation into a disposable absorbent garment. An elastic element applicator is provided that is configured to move a section of a continuous strand of elastic element generally about a plane. A first web of material is conveyed in a first web moving direction such that the first web intersects the plane. Then, the applicator is operated to move the elastic element about the plane, thereby applying the section of elastic element onto the first web along a direction generally transverse to the web moving direction and such that the first web draws the continuous elastic strand from the elastic element applicator as the first web is conveyed away from the plane. The elastic element applicator may be in the form of a spin cylinder or bracket that is operated to spin the elastic element about the moving first web, thereby applying the elastic element on the first web.
US07740722B2 Steel for use in high strength pinion shaft and manufacturing method thereof
A steel for use in high strength pinion shaft which is not refined and used by applying high frequency hardening, with less occurrence of peeling during hobbing, having high surface hardness, impact value and torsional strength after high frequency hardening, and with less heat treatment strains during high frequency hardening, containing, on the mass % basis; C: 0.45-0.55%, Si: 0.10-0.50%, Mn: 0.50-1.20%, P: 0.025% or less, S: 0.025% or less, Mo: 0.15-0.25%, B: 0.0005-0.005%, Ti: 0.005-0.10%, and N: 0.015% or less, satisfying: 0.80≦Ceq 0.95 and f value≦1.0, and the balance of Fe and inevitable impurities, as well as a manufacturing method thereof.
US07740718B2 Target of high-purity nickel or nickel alloy and its producing method
Provided is high purity nickel or nickel alloy target for magnetron sputtering having superior sputtering film uniformity and in which the magnetic permeability of the target is 100 or more, and this high purity nickel or a nickel alloy target for magnetron sputtering capable of achieving a favorable film uniformity (evenness of film thickness) and superior in plasma ignition (firing) even during the manufacturing process employing a 300 mm wafer. The present invention also provides the manufacturing method of such high purity nickel or nickel alloy target.
US07740716B2 Rare earth sintered magnet
The present invention provides a technique to improve an adhesion strength between a magnet main body and a protective film. The rare earth sintered magnet of the present invention comprises a magnet main body of a sintered body containing a rare earth element and a protective film formed on the magnet main body, wherein the ratio of a 10-point average surface roughness Rz of the magnet main body on which the protective film is formed to a mean grain size D50 in the magnet main body (Rz/D50 ratio) is kept in a range from 0.20 to 10.00, inclusive. This gives the rare earth sintered magnet which is coated with the protective film having a high adhesion strength of 100 N/m or more and exhibits high corrosion resistance.
US07740715B2 R-T-B based sintered magnet
An R-T-B based sintered magnet according to the present invention has a composition comprising: 12 at % to 15 at % of a rare-earth element R; 5.0 at % to 8.0 at % of boron B; 0.1 at % to at % of Al; 0.02 at % to less than 0.2 at % of Mn; and a transition metal T as the balance. The rare-earth element R is at least one element selected from the rare-earth elements, including Y (yttrium), and includes at least one of Nd and Pr. The transition element T includes Fe as its main element.
US07740714B2 Method for preparing radially anisotropic magnet
A radially anisotropic magnet is prepared by furnishing a cylindrical magnet-compacting mold comprising a die, a core, and top and bottom punches, packing a magnet powder in the mold cavity, applying a magnetic field across the magnet powder, and forcing the top and bottom punches to compress the magnet powder for compacting the magnet powder by a horizontal magnetic field vertical compacting process. The top punch is divided into segments so that the magnet powder may be partially compressed; in the step of compacting the magnet powder packed in the mold cavity by a horizontal magnetic field vertical compacting process, the magnet powder is partially compressed by the segments of the top punch cooperating with the bottom punch for thereby consolidating the partially compressed zones of magnet powder to a density from 1.1 times the packing density to less than the compact ultimate density; and thereafter, the entire magnet powder in the cavity is compressed under a pressure equal to or greater than that of partial compression by the entire top and bottom punches for finally compacting the magnet powder.
US07740713B2 Flux composition and techniques for use thereof
The present invention is directed to soldering techniques and compositions for use therein. In one aspect, a flux composition is provided. The flux composition comprises a fluxing agent comprising organic acid, an organic tacking agent and an organic wetting agent. In another aspect, a soldering method for joining objects is provided comprising the following steps. A flux composition and a solder compound are applied to at least a portion of one or more of the objects. The flux composition comprises a fluxing agent comprising organic acid, an organic tacking agent and an organic wetting agent. The objects are then joined.
US07740707B2 Method for operating a vacuum cleaner
A method for operating a vacuum cleaner having a fan, an electronic control system for the fan and/or another load, and a dust chamber for receiving an air-permeable dust bag, includes providing the dust bag with an identifier, and providing the vacuum cleaner with an identifying device associated with the electronic control system and configured to identify the identifier. When the identifier fails to be identified, at least one of the fan and the other load is controlled using the electronic control system so as to reduce at least one parameter associated with an intake of dust into the dust bag.
US07740706B2 Gas baffle and distributor for semiconductor processing chamber
Apparatus and methods for distributing gas in a semiconductor process chamber are provided. In an embodiment, a gas distributor for use in a gas processing chamber comprises a body. The body includes a baffle with a gas deflection surface to divert the flow of a gas from a first direction to a second direction. The gas deflection surface comprises a concave surface. The concave surface comprises at least about 75% of the surface area of the gas deflection surface. The concave surface substantially deflects the gas toward a chamber wall and provides decreased metal atom contamination from the baffle so that season times can be reduced.
US07740705B2 Exhaust apparatus configured to reduce particle contamination in a deposition system
A method and system for vapor deposition on a substrate that disposes a substrate in a process space of a processing system that is isolated from a transfer space of the processing system, processes the substrate at either of a first position or a second position in the process space while maintaining isolation from the transfer space, and deposits a material on said substrate at either the first position or the second position. Furthermore, the system includes a high conductance exhaust apparatus configured to be coupled to the process space, whereby particle contamination of the substrate processed in the deposition system is minimized. The exhaust apparatus comprises a pumping system located above the substrate and an evacuation duct, wherein the evacuation duct has an inlet located below the substrate plane.
US07740702B2 Silicon wafer and method for manufacturing the same
A silicon wafer and a method for manufacturing the same are provided, wherein the silicon wafer has no crystal defects in the vicinity of the surface and provides excellent gettering efficiency in the process of manufacturing devices without IG treatment. The oxygen concentration and the carbon concentration are controlled respectively within a range of 11×1017-17×1017 atoms/cm3 (OLD ASTM) and within a range of 1×1016-15×1016 atoms/cm3 (NEW ASTM). A denuded zone having no crystal defects due to the existence of oxygen is formed on the surface and in the vicinity thereof, and oxygen precipitates are formed at a density of 1×104-5×106 counts/cm2, when a heat treatment is carried out at a temperature of 500-1000° C. for 1 to 24 hours. In the method for manufacturing the silicon wafer, moreover, the silicon wafer having the oxygen and carbon concentrations as controlled above is heat-treated at a temperature of 1100° C.-1380° C. for 1 to 10 hours. The control of the oxygen and carbon concentrations in the growth of a single crystal with CZ method allows a desired density of oxygen precipitates to be attained in the process of manufacturing devices and thereby sufficient gettering efficiency to be obtained.
US07740699B2 Orthoformate-protected polyols
Disclosed herein are coating compositions comprising a blocked polyol having a first hydroxyl group at position 1 carbon atom and a second hydroxyl group at position 2 or 3 carbon atom, wherein both the first and the second hydroxyl groups are blocked by a single hydrolyzable orthoformate group; and a polyisocyanate compound. Methods of producing and using said coating compositions are also disclosed.
US07740698B2 Non-asbestos friction material
A non-asbestos friction material not containing a heavy metal and a heavy metallic compound as the blending ingredients of the friction material is provided with graphite and coke in total from 5 to 25 vol % in volume of friction material. A volume ratio of the graphite/coke is preferably from 2/1 to 7/1. An average particle size of the coke is preferably from 150 to 400 μm.
US07740697B2 Aqueous ink, ink cartridge using the same, inkjet printing method and recorded matter
The invention provides an ink which has a higher fixation of a recorded matter, is more excellent in stability and reliability of the ink, and allows a recorded matter of high image quality to be obtained stably, a recorded image, an inkjet recording method, and devices using such an ink. The invention provides an aqueous ink including micromicelles which are dispersed in a transparent single phase in water, characterized in that the micromicelles are comprised of a combination of two or more surfactants which exhibit an opaque or translucent dispersed state in water and a compound having an alkyl group and having only a hydroxyl group as a water-soluble group, and an inkjet recording method, devices and a recorded image, using the aqueous ink.
US07740694B2 Ink jet ink composition and method for printing
Disclosed is an ink jet ink composition suitable for printing on substrates such as glass and metal. The ink jet ink composition comprises two or more organic solvents at least one of which is an alcohol, three or more binder resins comprising nitrocellulose, a thermoplastic polyurethane, and a polyvinylbutyral resin, two or more adhesion promoters, and a soluble colorant. Also disclosed is a method of printing images on such glass and metal substrates. The ink jet ink composition provides improved print quality and reduced need for cleaning the nozzle.
US07740689B2 CO2 absorption solution
Disclosed is a formulation for the absorption of CO2, which comprises water, at least one CO2 absorption compound and a carbonic anhydrase as an activator to enhance the absorption capacity of the CO2 absorption compound. The invention also concerns the use of carbonic anhydrase, in a CO2 absorption solution to increase the CO2 absorption rate of such solution.
US07740685B2 Process for removal of the catalytic coating material from spent, defective or unused metal support catalytic converters
Process for recovering catalyst coating material from a supporting structure, such as, for example, a catalytic converter assembly having a metal mantle, including contacting the catalytic coating material with a sodium, potassium or ammonium hydroxide-containing compound at an elevated temperature; and rinsing with a liquid and filtering the solid catalyst coating material from the solution.
US07740679B2 Air filter element with composite molded end cap
A method and apparatus are provided for constructing a filter element, having enhanced structural capabilities, through use of a molded end cap having first and second foam portions of differing physical properties meeting at a common juncture of the first and second foam portions and simultaneously cured with one another.
US07740676B2 Dust collection in vacuum cleaners
A cyclonic separator assembly for a vacuum cleaner, the assembly including a first cyclonic separator for effecting a first stage of dust separation from the suction airflow of the cleaner, and at least one further cyclonic separator for further separation of dust from the air flow following the first separator, and a receptacle for separated dust, the receptacle including respective receiving portions for receiving dust separated by the first separator and the further separator(s), wherein the respective portions of the dust receptacle are able to be emptied separately from one another.
US07740674B2 High-pressure separator
A high-pressure separator with improved efficiency is provided. The separator comprises a centrifugal separator located inside of a gravity separator. The centrifugal separator has an enclosed upper portion and desirably comprises a single cylinder. The high-pressure separator is particularly suitable for use in the production of low-density polyethylene under high pressure.
US07740671B2 Dump cooled gasifier
A dump-cooled gasifier includes a vessel, a liner, and coolant. The liner has a head end, an aft end, and a plurality of channels extending along a length of the vessel. The aft end of the liner is axially and radially expandable with respect to the head end of the liner. The coolant enters at the head end of the liner, flows through the liner, and is expelled from the aft end of the liner directly into the vessel.
US07740670B2 Catalyst for partial oxidation reforming of fuel and fuel reforming apparatus and method using the catalyst
Disclosed is a catalyst for a partial oxidation reforming reaction of fuel in the form of disk having through-hole. In addition, according to the invention, there is provided a fuel reforming apparatus and method using the catalyst. The catalyst for a partial oxidation reforming reaction of fuel according to the invention makes it possible to progress the partial oxidation reforming reaction of fuel smoothly, to improve the efficiency when reforming the fuel and to simplify the fuel reforming reactor. According to the fuel reforming apparatus and method, since the heat of reaction is efficiently controlled and used, a simple on-off operation, reduction of starting time and a stable operational condition are accomplished, which are indispensably required for a fuel reforming system in fuel cells, such as household, portable and car fuel cells.
US07740668B2 Unleaded aminated aviation gasoline exhibiting control of toluene insoluble deposits
The present invention relates to an unleaded aminated aviation gasoline of high motor octane number (MON) and low toluene insoluble deposit formation containing an additive for controlling said deposits selected from the group consisting of high molecular weight hydrocarbyl amines, high molecular weight hydrocarbyl succinimide, high molecular weight hydrocarbyl substituted Mannish bases, and mixtures thereof, and optional carrier oil(s), to an additive concentrate for controlling toluene insoluble deposits, and to a method for producing the additive concentrate.
US07740667B2 Method of fabricating an electrode plate for rechargeable battery
An electrode plate of a rechargeable battery that is capable of preventing wastage of a base film and preventing an active material layer from being irregularly formed and a method for fabricating the same is disclosed. The electrode plate is fabricated by continuously coating the active material layer lengthwise along a surface of the base film and cutting the base film in a direction substantially perpendicular to a length of the base film or in a direction that forms a predetermined angle in relation to the length of the base film. The method includes forming an active material layer lengthwise on a base film except for on predetermined parts of both ends of the base film by continuously coating active materials, and forming an electrode plate by cutting the base film formed with the active material layer in a direction substantially perpendicular to the length of the base film using a cutter.
US07740664B2 Composition comprising at least one silicone compound and at least one organosilane
The present disclosure provides a composition for treating keratin fibers, for example, human keratin fibers such as the hair. The present disclosure provides a composition for dyeing keratin fibers, comprising: at least one compound X and at least one compound Y, wherein at least one of the compounds X and Y is a silicone compound, wherein when X and Y are placed in contact with each other they react together via a hydrosilyation reaction, a condensation reaction, or a crosslinking reaction in the presence of at least one peroxide; and at least one alkoxysilane comprising a single silicon atom.
US07740650B2 Electrical stimulation unit and waterbath system
A method for treating an infected area on a subject, comprising the steps of: exposing the infected area to an aqueous solution; and providing direct current to the aqueous solution to treat the infected area.
US07740647B2 Necklift procedure and instruments for performing same
Provided herein is a method of performing surgery and the associated instruments therefor. The method includes the steps of placing a tape template onto a portion of a patient's skin, marking a plurality of access sites, making an opening to form a mid-line access site, performing liposuction, forming a plurality of openings in the skin at the access sites, inserting a skin port into each of the openings, inserting a skin port into the mid-line access site, providing a threading device having a suture tied thereto, inserting the threading device and suture through at least one skin port to form a suture matrix under the skin, pulling the ends of the suture through the skin port in the mid-line access site, tying the ends of the suture into a knot, pushing the knot through the skin port in the mid-line access site and under the skin, and removing the skin ports from the openings at the access sites.
US07740646B2 Adhesives for use with suture system minimize tissue erosion
A design for a suture for use in suture appositioning techniques, and a method for use are disclosed. In one embodiment the suture may comprise a hollow length having a wall forming a lumen, which may serve as a conduit through which fluid may be pumped and discharged through a plurality of perforations in the wall. In another embodiment the suture may comprise a plurality of suture members connected by a connecting member. In one embodiment of a method disclosed, a suture having a hollow length having a wall forming a lumen, with a plurality of perforations in the wall, may be placed in a stitching procedure to apposition tissues, and a fluid such as an adhesive, adhesive activating agent or drug may be pumped through the lumen and discharged out the perforations for various beneficial effects.
US07740644B2 Embolic protection filtering device that can be adapted to be advanced over a guidewire
An improved embolic protection filtering device. In at least some embodiments, an embolic protection filtering device includes a filter wire assembly. The filter wire assembly may include an elongate shaft, a tubular member, and an embolic protection filter.
US07740643B2 Nasal cavity dilator
An adjustable nasal cavity dilation device includes a first deformable body having a shape corresponding to the nasal cavity. Top and bottom frame ends of the body are interconnected by a flexible wall structure that undergoes deformation in response to movement of one frame end relative to the other. A releasable holding member includes a ring that engages the bottom frame end and an upstanding central member that engages the top frame end. The ring and the upstanding central member are coupled by a plurality of radial arms. The flexible wall structure is deformed and effective for urging against nasal cavity walls to increase air flow through the nasal passage when the top and bottom frame ends are maintained in a holding condition by the ring and the upstanding central member. The ring and radial arms define openings that permit passage of air into and out of the nasal cavity through the releasable holding member.
US07740638B2 Apparatuses and methods for heart valve repair
A medical device for treating a heart having a faulty heart valve is disclosed. The medical device comprises a ligature including a first anchoring member and a second anchoring member is used. The ligature is percutaneously deployable into a patient with a faulty heart valve wherein the first anchoring member to anchor to a first tissue area of the heart and the second anchoring member to anchor to a second tissue area of the heart.
US07740635B2 Minimally invasive method and apparatus for placing facet screws and fusing adjacent vertebrae
A minimally invasive apparatus for placing screws across a facet joint between first and second vertebrae comprises a first K-wire for inserting into a spinous process of the first vertebrae and a first fixation block removably connected to the first K-wire. The apparatus has a second K-wire for inserting into a transverse process of the second vertebrae and a second fixation block removably connected to the second K-wire. A first rod member is removably connected to both of the first and second fixation blocks. A support apparatus further secures the first and second K-wires to the first and second vertebrae. The apparatus has a cannula that enables implantation of the translaminar screws across a facet joint between the first and second vertebrae.
US07740634B2 Method of bone plate shaping
Removable guide tips are pre-assembled into threaded holes of a fracture fixation plate. The guide tips may be used with or without drill guides to guide a drill along the axes of threaded holes defined in the plate. In addition, the tips may be used with bending tools to contour the plate laterally, longitudinally and with twist. More particularly, such plate contouring can be performed while the plate is located on the bone.
US07740633B2 Guide pin for guiding instrumentation along a soft tissue tract to a point on the spine
Disclosed are surgical tools, tool sets and methods for percutaneously accessing and preparing treatment sites within the spine for subsequent treatment procedures. The treatment site may be an inter-vertebral motion segments in the lumbar and sacral regions of the spine. The tool set may comprise introducer tools and bone dilators for accessing and tapping into a targeted site, such as, for example, the anterior surface of the S1 vertebral body. The tool set may also comprise cutters and extractors for preparing the treatment site for subsequent treatment procedures. The tool set may additionally comprise a bone graft inserter, an exchange system, and/or a temporary distraction tool for further preparing the treatment site for subsequent treatment procedures.
US07740629B2 Ablation catheter
An ablation catheter 10 includes an elongate carrier 12. A first loop 14.1 is arranged at, or adjacent, a distal end of the carrier 12. At least one sensing electrode 40 is carried on the first loop 14.1 for sensing irregular electrical activity in a patient's body. At least one further loop 14.2 is arranged proximally relative to the first loop 14.1 on the carrier 12 in a fixed orientation relative to the first loop 14.1. At least one ablating electrode 42 is carried on the second loop 14.2 for ablating a site of the patient's body where irregular electrical activity occurs.
US07740628B2 Surgical appliance
In order to improve a surgical appliance comprising a housing having at least one sealed cavity, and a drive unit arranged in the housing, such that the cavity can be sealed in a simple way, and the formation of germs can be reduced or these can be removed in a simple way from the cavity, it is proposed that a fluid connection be provided for forming a flow path into and out of the cavity, and that at least one sealing element be provided for closing the fluid connection to liquid fluids and opening the fluid connection to gaseous fluids.
US07740620B2 Insertion system and methods for nasogastric tubes including feeding tubes
A nasogastric tube insertion system comprises a nasogastric tube, a guide element, and an inserter element. The inserter element has a slim, elongate main body, a handle attached to the body, and an anatomically curved insertion section. The guide element comprises a swallowable weight attached to a cord, string, monofilament line, or other similar line. The nasogastric tube may be a nasogastric feeding tube and comprises a tube having one or more interior bores or lumina and a guide element capture structure. In use, the swallowable weight is placed onto the end of the inserter element. The inserter element is inserted through the patient's nasal passages and optionally into the oropharynx. The weight is released and the patient swallows it into the stomach. The guide element is threaded through the guide element retaining structure, and the nasogastric tube is safely inserted along the guide element into the patient's stomach. The tube and guide element are removed together when no longer needed.
US07740612B2 Self-administration injection system
Self-injection system allows a user to inject a drug from a cartridge carrying unique identification information, into any one of a plurality of injection sites. Tissue at each injection site is associated with at least one injection parameter, such as flow-rate, that is different for each site. A scanner reads the identification information of the cartridge and cooperates with a central processing unit to determine the validity of the drug in order to permit an injection procedure to commence. The central processing unit has a memory for storing the different injection parameters and controls a drive unit for driving fluid from the cartridge and through a needle into the selected tissue, at the injection parameter that is associated with the user selected tissue for the injection.
US07740611B2 Method and apparatus to indicate prior use of a medical item
The present invention monitors an IV bag injection port and informs the user of prior injections. The present invention employs an object and/or a sealed chamber within a transparent IV fluid bag injection port. In the case of the object, notification of prior use is achieved when the object's or IV fluid's appearance is altered. With respect to the sealed chamber, the chamber's seal is breached to allow fluid to pass between the chamber and the IV bag to change the appearance of the contents of the chamber. Since the injection port and bag walls are at least partially transparent, medical personnel are able to observe the altered appearance of either the object, IV fluid or the sealed chamber.
US07740607B2 Modular units for use in an injection device
Injection devices comprising multiple sections, e.g., modular components, are disclosed. In some embodiments the injection system comprises an upper section comprising a compressed gas reservoir, and one or more lower sections, e.g., modular components, containing one or more compositions to be injected. Methods of making and using the injection devices are also disclosed.
US07740603B2 Removable flexible orthosis for middle foot damage
A removable flexible orthosis for the middle foot comprising a) a first metatarsophalangeal collar that encircles and is fixed on the forefoot, and extends transversely from the heads of the first to the fifth metatarsi, and longitudinally from the toe's root towards the mid-diaphysis of the metatarsi, and b) a traction strap comprising at least one end fixed or fixable on the first metatarsophalangeal collar and on the portion of the orthosis designed to be applied on the rear of the foot is provided. The two ends of the stirrup-shaped traction strap can be fixed on the postero-external and postero-internal edges of the first metatarsophalangeal collar on the sides of the foot.
US07740601B2 Notebook computer with low-frequency electrotherapy
A notebook computer with low-frequency electrotherapy is provided. A low-frequency massage device including a pulse generator and massage pads is disposed in the mainframe of the notebook computer. The pulse generator is electrically coupled to a power supply of the mainframe, which supplies power for the pulse generator, and the massage pads are selectively connected to a low-frequency generator, such that while operating the notebook computer, a user attaches the massage pads on suitable parts of his/her body to enjoy the low frequency electrotherapy massage.
US07740596B2 Biopsy device with sample storage
A biopsy device and method are provided for obtaining and storing multiple tissue samples. The device permits the tissue samples to be stored in an end to end configuration. The device can include a sample tube having a sample lumen and a generally parallel vacuum lumen. A movable member, such as rod, can be advanced to uncover a predetermined number of fluid passageways between the sample lumen and the vacuum lumen as each sample is severed.
US07740590B2 Apparatus and method for determination of stroke volume using the brachial artery
Provided herein are methods and apparatus for stroke volume determination by bioimpedance from a patient's upper arm, or brachium, or a patient's thorax, utilizing pulsations of the arteries contained therein. The apparatus includes two or more spaced apart alternating current flow electrodes positioned on the patient's arm or thorax and two or more spaced apart voltage sensing electrodes positioned on the patient's arm or thorax and in-between alternating current flow electrodes. The system and method utilizes voltage sensed by the voltage sensing electrodes to calculate a cardiogenically induced impedance variation value of the patient, and to determine a stroke volume of the patient by multiplying the cardiogenically induced impedance variation value by a volume conductor VC and by a left ventricular ejection time TLVE.
US07740588B1 Wireless respiratory and heart rate monitoring system
A combined respiratory and heart rate sensor for a mammal has a flexible support with a surface adapted to be positioned over the skin of a mammal. A pair of inductive coil or capacitive plate elements, spaced apart by a foam spacer having openings therein, are attached to the support surface and are capable of independently sensing respiratory movement of the mammal in a direction perpendicular to the support surface and producing an output signal proportional thereto. The heart rate sensor includes an LED attached to the flexible support capable, and at least two light-detecting elements spaced apart from the LED, each capable of independently sensing light radiation reflected through the skin and capillaries from the light-emitting element and producing an output signal proportional thereto. A barrier layer attached to the support shield from the light-detecting elements light radiation that is not emitted from the LED.
US07740581B2 Methods of determining concentration of glucose
A region of skin, other than the fingertips, is stimulated. After stimulation, an opening is created in the skin (e.g., by lancing the skin) to cause a flow of body fluid from the region. At least a portion of this body fluid is transported to a testing device where the concentration of analyte (e.g., glucose) in the body fluid is then determined. It is found that the stimulation of the skin provides results that are generally closer to the results of measurements from the fingertips, the traditional site for obtaining body fluid for analyte testing.
US07740580B2 Analyte monitoring
Methods for covering an opening in an analyte meter are provided. Also provided are methods of determining analyte concentration.
US07740576B2 Articles, devices, and methods for pelvic surgery
Described are implants, tools, and related methods, for use in pelvic surgery to treat conditions such as prolapse and incontinence, including one embodiment of a method that uses a transcoccyx tissue path; other embodiments that use particular implants with various features relating to, e.g., end portions; and other embodiments relating to particular tools.
US07740572B2 Resistance chair with wheels
A resistance chair with wheels assists users with performing correct abdominal crunches by guiding the user's effort. The resistance chair includes a seat connected to a hinged back with back support that extends to support the user's back and assist in the crunch recovery following the crunch extension.
US07740571B1 Exercise apparatus
Exercise apparatus includes rotatable horizontal cylinder supporting user in a wide variety of exercises. Transversely spaced elongated handles extend from behind and lower than the cylinder upward and forward to substantially higher than the cylinder. The frame, cylinder, and elongated handles arranged so that user's body is supported primarily by the cylinder while user's hands can grasp the elongated handles sequentially higher and lower positions and can selectively pull and push translating user's body fore and aft on the cylinder. In exemplary embodiment, handles are bowed with upper portions positioned substantially above said cylinder to enable user sitting on said cylinder to reach upward and grasp handle upper portions, and frame includes transversely spaced posts, handles include portions extending downward to engage posts. Other features include lower handle set, vertically adjustable cylinder and soft surface cylinder and handles.
US07740568B2 Exercise machine having rotatable weight selection index
The present invention is a weight exercise machine for use by a user. The machine comprises an exercise member, a plurality of weights, and an index. The user exerts an exercise force against the exercise member when using the machine to exercise. The index is rotated to operably couple the exercise member to at least one of the weight plates such that the displacement of the exercise member causes the at least one of the weight plates to displace. The plurality of weight plates includes a first weight plate type and a second weight plate type having configurations and masses that differ. The index allows selection of different combinations of weight plates for operable coupling to the exercise member.
US07740567B2 Shoe accessory
The shoe accessory includes a platform for supporting a conventional shoe. The shoe accessory's base has a convex or other non-planar surface that causes the shoe accessory to be stable in a longitudinal (heel-toe) direction, and unstable in a lateral (medial/lateral) direction. The non-planar surface may be defined by a ridge segment on the platform's bottom side. One or more straps are provided to temporarily secure the wearer's conventional shoe to the platform in a non-destructive manner. A generally U-shaped heel retainer may be provided adjacent a rear portion of the platform for receiving the heel of the shoe. The shoe accessory makes a flat-soled shoe laterally unstable while allowing for longitudinal stability and a naturalistic gait, and thus facilitates exercise of leg and foot muscles during normal walking, etc.
US07740564B2 Stationary exercise apparatus
The present invention relates to a stationary exercise apparatus having an adjustable assembly connected to the frame for changing the position of the console or the handles. The stationary exercise apparatus comprises a frame, an adjustable assembly which has part of the frame, a moving member pivoted to the frame, a guiding mechanism interconnected the moving member and the frame, and an upright post mounted on the guiding mechanism, a crank unit mounted on the moving member, left and right supporting members respectively connected to the crank unit, left and right swing members respectively connected to the left and right supporting members, and left and right pedals respectively coupled to the left and right supporting members.
US07740562B2 Exercise equipment apparatus and method of use in tractor-trailers with sleepers
Apparatus and method of factory or post-manufacture installation of at least two exercise equipment units in tractor-trailer vehicles with sleepers. The exercise equipment units are stored initially in storage compartments located under beds behind the driver and passenger seats. The exercise equipment units are securely held within the storage compartments by storage locking mechanisms. Each exercise equipment unit is movable manually or electronically from the storage compartment to an operational or use position within the tractor-trailer walking space or sleeping area. In the operational position, the selected exercise equipment unit is secured by an operation locking mechanism in the operational position; adjusted and setup for use by multiple users. The exercise equipment units are connected to a computer for sensing, remote monitoring and displaying of vital signs of at least two users. The selected exercise equipment unit may be returned manually or electronically to either the first or said second storage compartment and re-secured in the storage compartment.
US07740559B2 Shift control device of vehicular automatic transmission
A shift control device of a vehicular automatic transmission, if during a first shift in a power-off state, a second shift judgment for a second shift that is a power-on downshift is made, performs a second shift control of lowering an input shaft rotation speed to a synchronous rotation speed of a post-second shift gear step through an engagement control of the friction engagement devices, and when the second shift is performed, performs a control of reducing a throttle valve opening degree of the engine to a predetermined degree that causes the engine to output a torque that is able to bring the input shaft rotation speed to a rotation speed that is higher than the synchronous rotation speed of the post-second shift gear step. The control device also executes a retardation control of retarding an ignition timing of the engine when the input shaft rotation speed is dropped through the second shift control.
US07740556B2 Hydraulic control apparatus and hydraulic control method
A hydraulic control apparatus includes two oil flow control valves (30, 32) each provided with a supply control portion (36, 38, 52, 54) for controlling an oil supply from a pressurized oil source, and a discharge control portion (40, 42, 56, 58) for controlling connection with a discharge passage. One of those oil flow control valves supplies/discharges oil to/from one of hydraulic chambers (22, 24) that are oppositely formed in a hydraulic servo mechanism. An operation direction of the hydraulic servo mechanism is performed by operating one of the oil flow control valves. The other operation direction of the hydraulic servo mechanism is performed by operating the other oil flow control valve.
US07740553B2 Detachable feed tray with self adjusting side guides
A method and mechanism are provided for controlling the movement of a belt. The arrangement may have a moveable member is coupled to an adjustable member. The members are coupled such that when the moveable member is moved in a first direction the adjustable member is move in a first direction and when the moveable member is moved in a second direction the adjustable member is moved in a second direction. A belt is coupled to the movable member. Movement of the belt in a first direction moves the moveable member in the first direction and movement of said belt in a second direction moves the moveable member in the second direction. A belt tensioner mechanism is connected to the belt so that when the belt moves in the first direction a biasing force is created that drives said belt to move a controlled amount in the second direction when movement of the belt in the first direction is stopped. The arrangement may be employed with a materials feed tray. Side guides for the tray are automatically set correctly for proper feeding from the tray without jamming, skew or off set of the materials.
US07740549B2 Device for training and improving a volleyball spike technique
The invention relates to sports training devices and can be used for training a volleyball spike-motion. The inventive device comprises a bearing frame, a ball, and a unit for returning the ball to the initial position thereof, which unit is provided with an elastic stretching connected to the frame by one end thereof, a rod whose one end is fixed to the frame in such a way that it has at least two degrees of freedom, whereas the second end of the rod is connected to the ball, and the second end of the stretching is connected to the rod. The frame is also provided with a limiter of traveling the rod. The device enables the ball to be moved along an arc, thereby increasing the quality of the spike-motion training, and improves effectiveness and safety of the training.
US07740547B2 Multi-piece solid golf ball
The present invention provides a multi-piece solid golf ball having a core obtained by molding under heat a specific rubber composition and having a cover of at least three layers which is composed of a thermoplastic resin material and encases the core. By optimizing the deflection of the core under a specific load, optimizing the hardness at the center of the core and the hardnesses of the innermost cover layer, outermost cover layer and intermediate cover layer, setting the combined thickness of the cover layers to at least a specific value, and forming the innermost cover layer of a highly neutralized ionomer resin composition, the spin rate of the ball on shots taken with a driver can be significantly reduced, enabling the distance traveled by the ball to be increased. Moreover, the ball has a good feel on shots with a driver.
US07740544B2 Method of enhancing participant's performance in a sporting activity
According to one aspect of the present invention, a method of improving a participant's ability to move an object toward a desired target through athletic movement is provided. The method comprises establishing a point of focus that is positioned outward from a participant's body. The method further comprises instructing the participant to continuously move the point of focus through one or more series of bodily movements within the field of vision of the participant. By shifting his or her emphasis on continuously moving the point of focus, the participant is able to improve focus and concentration, and eliminate the stress and anxiety associated with executing an athletic movement. The method also naturally triggers correct body mechanics, including the proper sequential release of the participant's joints.
US07740539B2 Multi-person games for parimutuel betting on live events
A parimutuel betting game featuring in-game wagers and payoffs, and real time parimutuel style odds, based on events unfolding during a live event, a principal objective being to acquire the largest number of betting tokens by the end of the event. An administrator oversees a plurality of betting lines associated with betting events. Players are allowed to bet tokens on an open betting line until it is closed by the administrator. The line will close at or before the time the situation in the live event changes appreciably, so the posted odds on the betting lines are in synch with the live event. When a line is closed, a new line may open. When a termination event occurs for a given betting event, the betting event is terminated and all lines that opened since the previous termination are paid off simultaneously in parimutuel style. The betting lines preferably have a hierarchical structure. The game may be played over the Internet.
US07740536B2 Gaming device having player selection of scatter pay symbol positions
A gaming device with a scatter pay formed by enabling a player to pick a plurality of symbol display areas. The symbols generated to be displayed in the picked symbol display areas of the scatter pay are evaluated by the gaming device for a winning combination. In one embodiment, whether an award is associated with a combination of symbols generated in the picked symbol display areas of the scatter pay is based on a separate scatter pay paytable. In one embodiment, the player is enabled to pick a predetermined number of symbol display areas upon the generation of a triggering symbol. Alternatively, the player is enabled to pick the symbol display areas to be included in a scatter pay based on making a wager of a predetermined amount.
US07740534B2 System and method enabling extension of a time element in a game
Disclosed herein is a system and method for facilitating the extension of a time-based element in a game of chance. In some embodiments, the time-based element may be extended as a result of a random event, such as the outcome of a random number generator. In other embodiments, the time-based element may be extended as a result of a player's purchase of the time extension.
US07740533B2 Method and apparatus for playing video poker with a redraw function
According to some embodiments of a video poker game of the present invention, a gaming device and/or controller may be configured to (i) output a pay table, (ii) deal an intermediate outcome, (iii) receive a request from a player to retain/discard a number of identified cards of the intermediate outcome, (iv) replace the discarded cards to create a primary game outcome, (v) determine a payout amount associated with the primary game outcome based on the pay table, (vi) determine one or more strategy options based on the primary game outcome to determine a secondary game outcome (e.g., holding selected cards from any in the final poker hand) (vii) determine a payout amount associated with one or more secondary game outcomes, (viii) receive a player selection to receive a strategy option, (ix) deal cards to a selected strategy, (x) determine whether or not the player achieves a winning secondary game outcome, and if so, (xi) output the payout amount associated with the winning secondary game outcome. Thus, in some embodiments, a video poker game of the present invention may allow a player to retain one or more cards of a primary video poker game, select a strategy based on the primary game outcome, and receive a payout if the player achieves a winning game outcome in the secondary game.
US07740531B2 Operation of a set of devices
A method of operating a set of devices comprises receiving a signal, for example at least part of a game world model from a computer program. The signal is analyzed to produce a real-world description in the form of an instruction set of a markup language and the set of devices is operated according to the description.
US07740530B2 Air handling system
An air handling system with an air intake device is provided. The air intake device includes first and second air/water separators having a baffle device positioned between the two separators to redirect the air flow from the first separator so that it is flowing generally longitudinally of the air intake device flow passage. A heater is provided to heat flowing air and snow for collection on a second separator having a foraminous device for subsequent collection and drainage from the air intake device.
US07740529B2 Coin dispenser with auto-latching coin canister
A coin dispenser includes a coin canister that automatically locks into the dispenser. A remotely operated mechanism may unlock the canister from the dispenser. The dispenser may serve as a loading stand for the canister. The canister may be adapted for manual loading of coins into the canister without removing the canister from the dispenser. The canister may include a receptacle for coins and an aperture adapted to facilitate loading coins into the receptacle and to retain coins in the receptacle. The canister may include a repositionable handle that covers an aperture of the canister in one position and serves as a carrying handle in another position. A system for dispensing coins includes a controller electrically connected to a coin dispenser. The dispenser includes a coin canister and a latch that locks the canister to the dispenser. The controller can send an electrical signal that unlocks the canister.
US07740528B1 Apparatus for cutting elongated meat
An apparatus for cutting elongated meat includes a frame that has a longitudinal axis and a motor proximate the frame. At least two generally circular blades are rotatably mounted to the frame each about a respective blade axis. Each blade axis is generally perpendicular to the longitudinal axis. The blades axes are positioned generally on an imaginary plane generally perpendicular to the longitudinal axis. The blades are rotated by the motor and cut the elongated meat when the elongated meat is placed generally collinear with the longitudinal axis and contacts the blades.
US07740526B2 Apparatus for the automatic stuffing of meat products into a double casing comprising a sheet and a net
A device for producing meat products by stuffing meat mass in a double casing made up of a film and a net, has a stuffing tube with a diameter, a mechanism for passing the meat mass through the stuffing tube and into the double casing and a mechanism for shaping the film into a cylinder that is adapted to the diameter of the stuffing tube, the shaping mechanism forming longitudinal folds for allowing radial expansion of the cylinder when the cylinder is fed with meat mass through the stuffing tube by unfolding the folds.
US07740519B2 Method for processing chamfering of eyeglass lens and apparatus for processing the same
A method for processing a chamfering of an eyeglass lens, including the steps of inputting a width of the chamfering and a range of the chamfering from a periphery of a lens shape at a position adjacent to a nose and/or a position far away form the nose, obtaining a trace of the chamfering on a refractive surface of the eyeglass lens and displaying the trace of the chamfering by overlapping the lens shape.
US07740517B2 Multi-function yo-yo
A multi-function yo-yo switchable between operation as a traditional yo-yo, a free-spin yo-yo, and a centrifugal-clutch yo-yo. Within one or both of the fly disks is one or more rotational-speed governors, and about the axle is a cylindrical axle sleeve which is rotatable about the axle. Each governor is spring-biased to an inwards position the governor contacts the axle sleeve, forcing the axle sleeve to rotate with the fly disks and axle. However, when the yo-yo spins sufficiently rapidly, the governors are thrown by centrifugal force to a radially-outwards position so as not to be in contact with the axle sleeve so that the axle sleeve may rotate independently of the fly disks. A function control switch locks the governors in the inwards position or the outwards position or allows the position to be controlled by centrifugal force.
US07740516B2 Electronic speed control programming
A method and apparatus for programming an electronic speed controller for a radio controlled model including a programmer for interfacing a personal computer to the RX port of the electronic speed controller. The electronic speed controller software may be updated, modified or replaced through the RX port.
US07740515B2 Flat panel display and method of fabricating the same
A light-emitting display device the same includes an insulating substrate having a thin film transistor formed thereon. The thin film transistor includes a source electrode and/or a drain electrode. A passivation layer is formed on the insulating substrate over at least a portion of the thin film transistor, and has a via hole formed therein, which electrically contacts either the source electrode or the drain electrode. A pixel electrode is formed in the via hole. A light-blocking layer is formed over an entire upper surface of the passivation layer except for an area corresponding to the pixel electrode. A planarization layer is formed on an upper surface of the light-blocking layer except for an area corresponding to the pixel electrode.
US07740509B2 Electrical wire connector
Electrical connectors, particularly for connecting telephone wire pairs, are disclosed in which connector strips having at least one row of apertures containing wire connection terminals is provided with at least one captive wire insertion tool which can push or otherwise force wires into terminals of the connector strip to establish electrical connection. The or each tool is mounted for captive sliding movement relative to the strip to position the tool with a selected one of the apertures in which a wire connection is to be made. In one form of the invention, a tool is adapted to slide along the strip so that it can be positioned at each aperture. In a further embodiment, the strip is provided with a plurality of tools, one for each aperture.
US07740507B2 Coupling for solenoid and lead frame
A coupling for a solenoid and a lead frame includes plurality of terminals. Each terminal includes a plurality of terminal guides. A lead frame defines a plurality of slots. A plurality of locating and support channels are defined adjacent each slot, wherein each of the plurality of terminals are coupled to a respective slot on the lead frame, and the plurality of terminal guides on each terminal are located in the plurality of locating and support channels defined adjacent a respective slot.
US07740504B2 Fuse and power circuit breaker including the same
A power circuit breaker having a simple structure with a small number of components is provided. The power circuit breaker includes: a circuit receiver which receives a pair of circuit terminals connected to an end of an opened power circuit; and a plug body having a fuse to be mounted on the circuit receiver to close the power circuit. In the fuse, a pair of terminals extending from a housing, which receives a fuse element of the fuse, is bent approximately at right angles at the middle of the terminal. A central curving portion of the bent part is provided with a notch. A cross section of the terminal exposed within the notch is pressed by a jig, which fits with the notch, so that the fuse is press-fit into the plug body.
US07740500B2 Electrical plug connector
The invention concerns an electrical plug connector with an insulating contact carrier that contains a number of electrical contacts in the form of contact pins or contact sockets that are arranged parallel to each other, and which can be inserted axially into a plug connector housing, with the contacts being accessible from the front side of the contact carrier, and with the contacts having connecting elements on a rear side of the contact carrier for a connection with electrical power supply lines. The invention proposes to divide the plug connector housing in the insertion direction into a front and a rear housing section that are connected to a hinge joint by means of a swivel axle that is oriented orthogonally to the insertion direction. In a straightened operating position of the plug connector housing, the axially inserted contact carrier that at least partially engages the two housing section and is in lateral contact with said housing sections at least is some sections reliably prevents the swiveling of the housing sections and therefore the opening of the plug connector housing.
US07740498B1 Advanced backward compatible connector assembly for electrically connecting computer subsystems
A backward compatible connector assembly that facilitates electrical communication between computer subsystems includes a receptacle, a receiver assembly and a conductor array. The receptacle includes a plurality of first connectors having a first connector length, and a plurality of interspersed second connectors having a second connector length that differs from the first connector length. The first connectors include data pins and the second connectors can include ground pins for single-ended signaling. Alternatively, the second connectors can include a plurality of data pins to form differential pairs of connectors for low voltage differential signaling. The receiver assembly includes first connector receivers that receive the first connectors, and second connector receivers that receive the second connectors. The conductor array can include approximately 40 signal-bearing conductors that have interspersed ground lines or signal-bearing lines. The first connector receivers have a first receiver depth that is different than a second receiver depth of the second connector receivers. The connector assembly can include 40 first connectors and first connector receivers, and 38 second connectors and second connector receivers.
US07740495B1 Portable storage device
A portable storage device essentially comprises a body and a protecting cap. The portable storage device is convenient to use since the portable storage device can be opened or closed easily by a pushing action.
US07740494B2 Data storage apparatus
The present invention discloses a data storage apparatus, including a memory module, a USB connector connected with the memory module, a housing for accommodating the memory module, a movable carriage for holding the memory module and the USB connector, and a rotary driving mechanism for transmitting a rotary motion into a linear motion for driving the USB connector.
US07740493B2 Universal serial bus (USB) flash drive housing a slim USB device and having swivel cap functionalities allowing for two locking positions
A Universal Serial Bus (USB) flash drive includes a slim USB device having an end used to couple the USB flash drive to a host and an opposite end and a swivel cap having a side slit that serves as an opening into which the slim USB device travels horizontally, the side slit being disposed along a lateral side of the swivel cap. The USB flash drive also includes a USB device rivet placed into the slim USB device and the swivel cap to pivotally connect them at one of the ends of the slim USB device, so that the slim USB device is pivotally extendable outwardly from the side slit in a closed or open position. The swivel rocker is pivotally extendable outwardly from the opposite end of the slim USB device and when the swivel rocker is extended outwardly, the slim USB device is caused to extend outwardly.
US07740486B2 Printed circuit board connection
An electronic device, comprising an improved printed circuit board connection for connecting a first printed circuit board to a second printed circuit board in a manner that permits physical engagement at a different position than the electrical engagement, and a method for making the improved printed circuit board connection with precision in alignment. In one embodiment, the first printed circuit board includes an end portion configured to engage with a member of a connector on the second printed circuit board. The end portion and the member engage along concave portions of the end portion and convex portions of the member. When engaged, the end portion and the member align wires of the first printed circuit board with terminals of the connector.
US07740482B2 Stable cationically crosslinkable/polymerizable dental composition with a high filler content
Stable and substantially filled cationic dental compositions are described which include: (1) at least one cationically reactive compound (A); (2) at least one dental filler (B); (3) optionally, at least one dispersant (C) composed of at least one organic polymer or copolymer; (4) at least one cationic photoinitiator (D); and (5) optionally, at least one photosensitizer (E). The dental filler (B) is treated with at least one organosilicon coupling agent (F), and at least one compound (G). The organosilicon coupling agent (F) has at least one reactive function (rfA) directly linked to a silicon atom forming after activation of a chemical bond with the dental filler, and at least one reactive function (rfB) not directly linked to a silicon atom, forming after activation, a chemical bond with a reactive function (rfC) of the compound (G).
US07740481B2 Osteointegrative interface for implantable prostheses and a method for the treatment of the osteointegrative interface
An interface including a substrate of biocompatible material such as titanium, tantalum or their alloys having, on the surface of the substrate, a first layer having a first concentration of oxide of the biocompatible material, enriched with a second concentration of phosphorus and with a third concentration of calcium, the ratio between the concentration of calcium and the concentration of phosphorus being greater than two. The interface also includes a second layer having a first surface in contact with the first layer and a second surface. The second layer has a fourth concentration of oxide enriched with a fifth concentration of calcium and a sixth concentration of phosphorus. The fourth concentration is less than the fifth and sixth concentrations and the ratio between the fifth concentration of calcium and the sixth concentration of phosphorus is no less than three.
US07740480B2 Sequence of canal instruments for executing an endodontic operative procedure
A sequence of canal instruments for performing an endodontic operating protocol uses a sequence of several instruments, for example, three such instruments with three cutting blades. The instruments have a progressive conicity, for example, 6%, 4% and 2%, and each instrument has an identical progressive pitch. The pitch further increases progressively from instrument to instrument as a function of the conicity of each instrument.
US07740477B2 Dental device for the investigation of the optical properties of tooth tissue
In a dental device for the investigation of the optical properties of tooth tissue, in particular for the recognition of caries, plaque, bacterial infection, concretions and tartar, having a generator for generating an excitation radiation, which is to be directed onto a tooth tissue region to be investigated, a radiation detector and a radiation evaluator for the detection and evaluation of a response radiation arising from the irradiated tooth tissue region as response to the irradiation, and an indicator means for the indication of a measurement result determined by the evaluation means on the basis of the detected response radiation, the excitation radiation generator, the radiation detector and at least also the indicator being integrated in a dental handpiece.
US07740476B2 Method and workstation for generating virtual tooth models from three-dimensional tooth data
A method is described for taking a three-dimensional virtual model of the dentition and associated anatomical structures of a patient and isolating individual teeth from the rest of the anatomical structure, e.g. gums, to thereby produce individual, virtual three-dimensional tooth objects. The individual tooth objects can be displayed on the display of an orthodontic workstation and moved independently from each other, and thereby form the basis of planning treatment for the patient. The individual, virtual three-dimensional tooth objects are created by comparing the virtual model of the dentition to virtual, three-dimensional template teeth that are stored in memory in a process described in detail herein. The template teeth can include roots as well as crowns. The template teeth can be stored objects acquired from some external source or alternatively developed from a database of patient scans. Virtual three-dimensional brackets are also stored in the memory of the workstation. The virtual brackets can be placed on the virtual teeth and moved relative to the teeth as needed in a preliminary step in treatment planning.
US07740475B2 Orthodontic apparatus with adjustable base plate and connecting plate
An adjustable orthodontic apparatus formed by at least one base plate having opposing sides, the first side being a tooth engaging side and the second side having a plurality of columns of protrusions and channels created by the columns of protrusions and at least one connecting plate having opposing sides, the first side having a plurality of columns of protrusions and channels created by the columns of protrusions and a front side having a cavity for receiving a wire. The protrusions are designed to travel within the channels during an adjustment stage. A securing device locks the connecting plate to a desired position on the base plate.
US07740474B2 Support for structural components and method for producing the same
A support for structural components that are subjected to a thermal treatment process. The support includes a frame having limbs and extending therefrom a grid of intersecting strands. In order to prevent the support from warping even when subjected to strong thermal loads or variations in temperature, the frame is produced from a temperature-resistant material and the strands are produced from carbon fibers or ceramic fibers that form the grid, extending from the limbs of the frame.
US07740473B2 Injection molding machine with heating plate
The molding apparatus includes a cavity mold with a cavity surface for defining a cavity in which a molten injection material is injected, and a core mold with a core surface for defining the cavity upon engagement with the cavity mold. The core mold has an intermediate core mold plate having the core surface and a support plate. A guide pin inserted into a guide hole formed in the cavity mold and fitted through the intermediate core mold plate to allow the intermediate core mold plate to be moved only in a forward and backward direction is fixed to the support plate. A first spring is installed between the intermediate core mold plate and the support plate, a first heating means is installed to a parting surface of the intermediate core mold plate and a cooling means is installed to the support plate.
US07740471B2 Mold having independent movable walls
A method for manufacturing products using a mold having at least one mold cavity which is at least partly defined by at least two movable wall parts, wherein the mold is closed and the at least two movable wall parts (35A, 35B) are brought to a retracted position relative to the mold cavity, so that the volume of the mold cavity is enlarged relative to the volume required for a product to be formed, wherein at least partly molten material is introduced into the mold cavity and then in a first step a first one (35A) of the at least two movable wall parts is set into motion in the direction of a forwardly moved position and in a second step a second one (35B) of the at least two movable wall parts is set into motion in the direction of a forwardly moved position, wherein the movable wall parts are moved into said forwardly moved position for the formation of the product.
US07740468B2 Rotary press
A rotary press with a stand, a rotor rotatably mounted around a vertical axis in the stand and being driven, which has an upper and a lower compression punch accommodation for upper and lower punches which co-operate with bores of a die plate of the rotor, and upper and lower control cam elements which can be detachably fastened on a cam carrier of the stand and which guide heads of the compression punches by means of control cams during the rotation of the rotor, characterized in that at least one control cam element, guiding the compression punch heads radially outside or radially inside, can be detachably fastened on the carrier and can be moved radially away from the punch heads when the fastening means is detached, so far that by-passing the punch heads, it can be taken out parallel to the axis of the rotor, towards the upside or towards the bottom side, respectively.
US07740466B2 Molding device for molding a weather strip
A molding device is provided with a holding portion for clamping the end of an extruded portion, and a cavity for forming a molded portion. The holding portion has holding cores to come in contact with the end of the extruded portion, and at least a part of the holding cores is formed by a material with a low thermal conductivity. Thus, the molding method of a weather strip includes, clamping the end of the extruded portion by the holding portions, then, ejecting or injecting a rubber material for molding the molded portion in the cavity, and then, molding the rubber by vulcanization.
US07740463B2 Pressurised metered dose inhalers (MDI)
The invention relates to the use of pressurised metered dose inhalers (MDIs) having part or all of their internal surfaces consisting of stainless steel, anodised aluminium or lined with an inert organic coating; and to compositions to be delivered with said MDIs.
US07740457B2 Means for delivery of flowable media, especially lubricants
A device for delivery of flowable media, especially of lubricants, includes a pump (1) driven by a motor and forming a component of a line system. At least one heating element (21) activated by energy supply is located outside of the housing (3) of the pump (1) in a position enabling heat transfer to the housing (3).
US07740455B1 Pumping system with hydraulic pump
A system for pumping liquid having a first reservoir at a first elevation, which stores a first liquid, a second reservoir at a second elevation, where the second elevation is substantially lower than the first elevation, the second reservoir stores a second liquid, a third reservoir at a third elevation, where the third elevation is substantially lower than the first elevation, the second elevation is higher than the third elevation, the third reservoir arranged to store the second liquid, and, at least one hydraulic pump connected to the first reservoir via a first conduit, connected to the second reservoir via a second conduit, connected to the third reservoir via a third conduit, the pump arranged to be powered by the first liquid when the first liquid is permitted to fall due to gravity, the pump arranged to pump the second liquid from the third reservoir to the second reservoir.
US07740452B2 Highly extensible power and/or signal transmission cable as well as rotor blade with such a cable
A fiber-composite rotor blade, especially of a rotary-wing aircraft, with a predefined rotor blade profile that has a predefined outer contour of the profile. The fiber-composite rotor blade includes a fiber-composite rotor blade structure having an upper and a lower cover skin and a profile core situated between them, and at least one highly extensible cable integrated into the fiber-composite rotor blade structure in the direction of the span of the rotor blade, whereby the cable can be connected to a functional device that can be attached onto or into the fiber-composite rotor blade structure. The cable is a highly extensible power and/or signal transmission cable that includes at least one cable strand with at least one first cable core made of an electrically insulating, elastic plastic material, and at least one first cable wire that is wound around the first cable core at a predefined pitch angle, like a spiral and free of crossovers.
US07740450B2 Lightweight hub for rotors
A structure for a hub of a rotor includes a space frame having truss members configured to carry primary torsion, bending, and direct loading. The structure also includes a shell on the space frame configured to stabilize the space frame and carry shear loading.
US07740447B2 Centrifugal pump for abrasive fluid
A centrifugal pump for abrasive fluid. The pump may include a bearing housing mounted to a tank containing an abrasive fluid. The bearing housing may house wear-susceptible components in a manner distancing and isolating the components from the fluid. A shaft may be coupled to the bearing housing and disposed through the tank to an impeller for dispensing the abrasive fluid beyond the centrifugal pump. Additionally the impeller itself may be housed within an impeller housing that is mechanically coupled to the bearing housing in order to enhance dimensional stability therebetween. Such a centrifugal pump may be coupled to other pumps such as higher pressure positive displacement pumps. In these circumstances the centrifugal pump may be used to facilitate the mixing of the abrasive fluid and provide a degree of pressurization thereto in advance of the fluid's use at an operation site. For example, where the fluid is a cement slurry, a triplex pump may be coupled to such a centrifugal pump for use in a cementing application at an oilfield.
US07740445B1 Turbine blade with near wall cooling
A turbine blade with a plurality of near wall cooling channels on both the pressure side wall and suction side wall of the blade, and a plurality of tip cooling channels that open into a concave impingement cavity formed on the upstream side wall of a squealer tip rail that extends from the trailing edge and along the suction side wall of the blade, around the leading edge and ends on the pressure side wall just past the leading edge. The tip cooling channels provide cooling for the blade tip and inject the spent cooling air into the concave impingement cavity which then redirects the spent cooling air toward the oncoming hot gas flow leakage to produce a cushion against the hot gas flow to push the flow up and over the tip. Cooling air from a root supply cavity flows up through the plurality of suction side cooling channels to provide near wall cooling for the blade, then discharges into a cooling air collector cavity formed between the pressure and suction side walls. The cooling air then migrates toward the platform and then flows into the pressure side wall cooling channels to provide near wall cooling, and then into the tip cooling channels before discharging into the concave tip cavity that extends along the tip rail.
US07740439B1 Wheel lifting device
A wheel lifting device for facilitating removal of a flat tire and positioning of a replacement tire includes a base bar being positionable on a support surface adjacent a tire. Each of a pair of arms is coupled to the base bar. Each of the arms has one of a pair of rollers rotatably coupled thereto. Each of the rollers is positioned between the arms to engage a tread of the tire. The rollers permit rotation of the tire to allow a rim to be rotated to properly align the rim with a wheel hub.
US07740438B2 Trolley and parking system using the same
A trolley and parking system using the trolley for transporting cars and the like. The present trolley includes a main body, capable of moving; and a clamping apparatus, having at least a first and a second moving plate and at least a pair of clamping claws. The present parking system includes a loading table, a differential table moving relative to the loading table, a trolley moving relative to the differential table, a longitudinal driving device, a power tube line transmission mechanism, and a power valve station and an electric control system thereof.
US07740435B2 Thread-tapping screw
A thread-tapping screw (11) has a thread (21) extending, starting from the screw shaft free end (15), at least along a portion of the shaft length and a height of which constantly decreasing toward the free end (15) of the shaft (12), and a plurality of cutting bodies (26, 36, 46, 56, 66) formed of a material having a greater hardness than hardness of the thread (21), located in recesses (24) formed in the thread (21) and opening radially outwardly and having, respectively, a radial outer profile (27, 37, 47, 57, 67) projecting, at least partially, beyond the thread and a height (A, B, C, D, E) of which decreases toward the free end (15) of the shaft (12) stepwise.
US07740431B1 Truck tie-down receiving system
A truck tie-down receiving system includes a pick-up truck that includes a cabin and a bed attached to the cabin. The bed includes a pair of lateral walls. Each of the lateral walls has an upper edge. A pair of mountings is provided and each of the upper edges has one of the mountings attached thereto. Each of the mountings has a plurality of apertures extending therethrough. Tie-down members may be extended through the apertures in the mountings to secure the tie-downs to the truck.
US07740424B2 Article separation apparatus and method for unit operations
An apparatus and method are disclosed for separating articles from a group of articles. The apparatus includes a container for containing one or more articles coupled to a suitable fluidizer for suspending articles within the container and transporting articles to an induction tube. A portal in the induction tube introduces articles singly into the induction tube. A vacuum pulls articles through the induction tube separating the articles from the group of articles in the container. The apparatus and method can be combined with one or more unit operations or modules, e.g., for inspecting articles, assessing quality of articles, or ascertaining material properties and/or parameters of articles, including layers thereof.
US07740421B2 Arrangement for the admission of pressurized water to spray systems
A water system for the admission of pressurized water to spray systems arranged on a powered support assembly for underground mining, having at least one spray system for plow or shearer track spraying and having at least one further spray system for goaf space spraying, canopy spraying and side spraying. A central water line feeds spray nozzles of the spray systems. To increase the operating reliability of the water system and thus of the powered support assembly, the control valves for the spray systems are accommodated in a spray valve block which is provided with a connection for the water line and which can be arranged on the powered support assembly as a unit separated from a hydraulic valve block.
US07740420B2 Retaining wall having artificial grass reinforcing fabric and methods for installing the fabric thereto
A reinforcing fabric for use in various applications, including retaining walls. Artificial grass is strategically provided on the fabric so that, when the fabric is positioned in the retaining wall installation, the artificial grass is at least visible on the vertical face of the wall.
US07740418B2 Buoyancy-based, underwater propulsion system and method
An apparatus for underwater propulsion. The apparatus may include a hydrofoil, a buoyancy compensator connected to the hydrofoil, a tank containing air, and a controller regulating the passage of air from the tank into the buoyancy compensator. The controller may also regulate the escape of air from the buoyancy compensator. By positioning the hydrofoil underwater and alternating between positive and negative angles of attack, a diver may generate forward propulsion by manipulating the controller to correspondingly alternate the buoyant force produced by the buoyancy compensator between levels below and above neutral buoyancy.
US07740414B2 Milling apparatus for a paved surface
In one aspect of the invention, an apparatus for directional degradation of a surface comprises an attachment assembly connected to a motorized vehicle comprising at least one degradation tool. The at least one degradation tool comprises a substantially cylindrical rotary degradation element having a substantially cylindrical working surface formed about a rotational axis. A plurality of cutting inserts is embedded within the substantially cylindrical working surface and is adapted to degrade a surface in a direction substantially normal to the rotational axis. At least one of the plurality of cutting inserts comprises a superhard material bonded to a cemented metal carbide substrate at a non-planar interface. The superhard material comprises a substantially pointed geometry with an apex comprising a 0.050 to 0.160 inch radius and a 0.100 to 0.500 inch thickness from the apex to the non-planar interface.
US07740410B2 Developing apparatus and developing method
A developing apparatus has a substrate holder to hold a substrate, a heater which is provided in a substrate holder, and heats a substrate on a substrate holder for processing a resist film by PEB, a cooler to cool a substrate on a substrate holder, a developing solution nozzle to supply a developing solution to a substrate on a substrate holder, and a controller to control a heater, a cooler and a developing nozzle.
US07740398B2 Dynamic mixer
A dynamic mixer includes a housing structure having a mixing chamber, having an inlet opening through which a material or materials to be mixed is passed into the mixing chamber and an outlet. A mixer rod has mixing rod portion disposed in the housing structure and a plurality of mixing paddle portions each having a mixing surface. The mixing rod is adapted for attachment to a drive unit which imparts a rotational mixing force to the rod. In one exemplary non-limiting embodiment of a mixer, the housing structure includes a hollow tubular structure with first and second open ends, a hollow T fitting having a first opening attached to the first end of the hollow tubular structure, a second opening opposed to and in alignment with the first opening and a third opening transverse to the first and second openings, and a coupler fitting attached to the second open end of the tubular structure. An end cap structure is attached to the second opening of the T fitting for supporting the rod drive portion for rotation and sealing against material leakage. A support structure is positioned at the second open end of the tubular structure and secured in place by the coupler fitting, to support the drive rod while permitting material flow out the open second end.
US07740393B2 Light guide plate and backlight module
A light guide plate (LGP) adapted to a backlight module having a light emitting surface, a bottom surface opposite to the light emitting surface, and at least one light incident surface contacting with the light emitting surface and the bottom surface is provided. The bottom surface has a plurality of flat surfaces and a plurality of groove groups. The groove groups and the flat surfaces are arranged in an alternating fashion. Each of the groove groups has at least two grooves. Each of the grooves has a first slanted surface, a peak, and a second slanted surface intersecting with the first slanted surface at the peak. In each of the grooves, a first edge side of the first slanted surface away from the peak is at a first distance from a second edge side of the second slanted surface away from the peak.
US07740392B2 Surface illumination apparatus and liquid crystal display
A surface illumination apparatus is provided which includes a laser light source and a light guide plate upon which a laser beam emitted from the laser light source is incident through an end-surface portion and from which the laser beam is emitted through a main-surface portion on one side thereof. The laser beam is incident through an end-surface portion at an inclination angle to a main-surface portion on the other side which faces the one main-surface portion of the light guide plate, undergoes a change in the optical-path direction thereof by the other main-surface portion, is incident on the one main-surface portion and is emitted as a substantially parallel beam from the one main-surface portion.
US07740387B2 Backlight wedge with side mounted light source
A backlight may include a light guide and a light input. The light guide may have a light reflection surface and a light emission surface. The light input may include a diverging wedge having a narrow end and opposing side surfaces extending to the narrow end. A light source may be disposed adjacent to one of the opposing side surfaces and may emit light into the light input portion. A multilayer polymeric mirror film may be disposed adjacent to the opposing side surfaces but not in intimate contact therewith and may reflect more than 95% of visible light incident on the multilayer polymeric mirror film.
US07740386B2 Lighting apparatus cable and lighting apparatus using the same
The present invention provides the lighting apparatus cable that allows it to easily attach the lighting module and enables it to improve the productivity. A flat cable used in a lighting apparatus having a plurality of lighting modules disposed in series, for connecting the lighting modules in such a manner that colors and/or luminous intensities of emitted lights of the lighting modules can be controlled, the flat cable comprising: at least four conductors disposed in parallel which include two signal conductors disposed at both sides of the cable and two power feeding conductors; a sheath member covering the at least four conductors to integrate; and notches formed on both sides of the cable so as to cut the signal conductors.
US07740381B2 Sports lighting fixture having die-cast frame in high-reflectance material
An apparatus and method for a high intensity lighting fixture. In one aspect, instead of a spun aluminum bowl-shaped reflector, a die cast metal reflector frame, somewhat simulating a bowl shape, includes an inner surface with mounting structure. A high reflectance sheet or plurality of high reflectance inserts are placed onto the mounting structure to create a reflecting surface. This allows high customability of the reflecting surface and minimizes light loss.
US07740375B2 High brightness illumination device with incoherent solid state light source
An illumination light source includes an incoherent solid state light source adapted to emit light over at least one light emission surface and having a total light emission surface area S0; a light circulation device including at least one light receiving surface adapted to receive the light from the incoherent solid state light source, and a light extraction area having a first surface area S1; and a light extraction device for extracting the light from the light circulation device at the light extraction area, wherein S1
US07740373B2 LED module for illumination
The present invention relates to an LED module for illumination, and more particularly, to an LED module for illumination capable of enhancing light emitting efficiency by having a light emitting structure, in which the thickness of an insulation substrate with an electrode pattern formed on a top portion thereof is minimized, a heat radiation substrate is formed by integrally attaching a radiator to a bottom surface of the insulation substrate, and LED elements are attached to the electrode pattern of the heat radiation substrate through silver epoxy with excellent heat conductivity as an adhesive agent, so that heat generated from the LED elements can effectively radiate through the radiator, white light is effectively generated from the light emitted from the LED elements, and the white light can be emitted to the outside maximally.
US07740369B2 Handheld power tool, in particular a power drill or screwdriver
A handheld power tool has a tool holder, which is received displaceably in a housing and is drivable via a drive unit that can be switched on and off upon an axial adjusting motion of the tool holder. A lighting unit on the handheld power tool can be switched on and/or off via the adjusting motion of the tool holder.
US07740365B2 Backlighting arrangement with semiconductor light sources arranged in light groups and lighting device
This invention relates to uniform backlighting of surfaces by semiconductor light sources. Various semiconductor light sources are combined into identical illumination groups. These identical illumination groups are arranged so that uniform backlighting of a surface is made possible. For homogeneous color mixing to be achieved, especially at edges, each illumination group in the arrangement has at least one adjacent illumination group in a different orientation.
US07740364B2 Backlight unit and liquid crystal display device employing the same
A direct light type backlight unit having a structure in which divided luminance areas are sequentially turned on and off and a liquid crystal display device employing the backlight unit are provided. The backlight unit includes: a base substrate; a plurality of point light sources arranged in a plurality of lines and mounted on the base substrate; and a reflector sheet vertically formed between lines of the point light sources, reflecting light emitted from the point light sources.
US07740359B2 Video display system with an oscillating projector screen
An apparatus for displaying images from a video projector. The apparatus includes a virtual projector screen assembly with an elongate screen element, such as a rod, that is mounted at one end to a base. The base is adapted for pivoting about its axis, arid a driver mechanism pivots the, base at high frequencies. During operation, the screen element oscillates between two edge positions with images projected from the projector being displayed on a side of the screen element facing or proximate to the projector. The two edge positions can be thought of as intersecting at the base and define a sweep angle (e.g., the angular difference between the two outer travel points of the screen element that is typically less than about 90 degrees). The driver may include a motor with an oscillating output shaft that pivots the base such as with a belt attached to the base.
US07740356B2 Monochromatic multi-resolution corneal topography target
A method to encode both high-resolution and low-resolution reflected features of a cornea to improve the measurements for reflection based corneal topography systems. The corneal topography reflective target provides for multiple resolutions of measurements to be obtained from a single acquisition.
US07740355B2 Device and method for determining optical parameters
The invention relates to a device (10) for determining the optical parameters of a user comprising: at least two image recording devices (14, 16), which are configured and arranged to respectively generate image data of at least sub-sections of the head of the user (30); a data processing unit comprising a user data determination device, which is configured to use the generated image data to determine user data relating to at least one sub-section of the head, or at least one sub-section of a system placed on the head that supports a pair of glasses (38) of the user (30) in a normal position of wear, the user data containing the three-dimensional location information of predetermined points in the head sub-section or the system sub-section and comprising a parameter determination unit, which is configured to determine at least some of the optical parameters of the user (30); a data output device, which outputs at least some of the determined optical parameters of the user (30). The invention also relates to an additional device, a corresponding method and a computer program.
US07740354B2 Multi-layered gradient index progressive lens
The present invention relates to a gradient index progressive addition spectacle lens that provides improved optical performance and a wide visual field. The lens comprises a plurality of axially layered and bonded lens sections of continuous curvature at least one of which has a refractive index gradient oriented transverse to a meridian of the lens that functions as a progressive intermediate vision zone between viewing portions of different refractive index that provide the refractive powers for corresponding vision portions of the lens. The other layer(s) of the lens incorporates a generally constant or similarly changing refractive index.
US07740352B2 Sports vision training device and method
A sports vision training device includes a pair of glasses with a frame supporting a left lens and a right lens. The right lens carries a right reticle, and the left lens carries a left reticle. The reticles provide visual references within the field of view of the player. The reticles may include upper and lower horizontal reference lines, vertical reference lines, a frame, and a crosshair pattern. Different patterns can be used for depth control training, timing control training, and early recognition for tennis and other sports.
US07740351B2 Ink-jet printing machine and printing method
An ink-jet printing machine has: a transfer belt that transfers a printing sheet; a sheet feeding unit that feeds the printing sheet; an ink-jet head that performs ink ejection on the printing sheet; a SS roller that presses a central region of the printing sheet between the sheet feeding unit and the ink-jet head; a printing sheet sensor that detects the deformation of the printing sheet; and a guide roller that presses the printing sheet. The rate of a distance A between the SS roller and the printing sheet sensor to a distance B between the upper surface of a transfer belt and the lower end of the printing sheet sensor is approximately equal to the rate of a distance A′ between the guide roller and the ink-jet head to a distance B′ between the upper surface of the transfer belt and the lower end of the ink-jet head.
US07740346B2 Resealed ink cartridge and method of manufacture
A resealed inkjet printer cartridge and method of manufacture in which an ink cartridge is reconditioned, recharged and resealed by a process which substantially eliminates “air lock” or interruption of ink flow to the printer head due to entrained air; which provides for welding together recharged cartridge subassemblies without the use of consumable adhesive or glue; and having a keyless cap adapted for use in various keyed cartridge receptacle inkjet printers.
US07740345B2 Actuator device, liquid-jet head and liquid-jet apparatus
Disclosed is an actuator device which includes a vibration plate and a piezoelectric element. The vibration plate includes an elastic film which is made of silicon oxide (SiO2) and which is formed on a substrate while the piezoelectric element is formed on the vibration plate and including a lower electrode, a piezoelectric layer and an upper electrode. The vibration plate has such a stress as to give a tensile stress between 300 MPa and 500 MPa, inclusive, to the piezoelectric element that is in a state of being displaced.
US07740344B2 Liquid droplet jetting apparatus and ink-jet printer
An ink-jet head includes a plurality of pressure chambers arranged in a paper feeding direction, and two manifold channels extended along the paper feeding direction. The manifold channel includes a first area which communicates with the pressure chambers, and a second area which is connected to an end of the first area, on a side opposite to an ink inflow port, and communicates with a plurality of dummy nozzles. A width of the second area is more than a width of the first area, and an acoustic capacitance of the second area, per unit length in the paper feeding direction is higher than an acoustic capacitance of the first area, per unit length in the paper feeding direction. Accordingly, it is possible to attenuate efficiently a pressure wave in the manifold channel.
US07740340B2 Inkjet printer with releasable print cartridge
An inkjet printer includes a cradle. A print cartridge can engage the cradle in a releasable manner. The print cartridge has a body housing a membrane which includes a number of ink storage reservoirs. The print cartridge also has a pagewidth printhead in fluid communication with the storage reservoirs. The printhead is configured to eject ink from the reservoirs. A fastening arrangement fastens the print cartridge within the cradle.
US07740339B2 Protection device for an ink cartridge storage unit
A protection device for an ink cartridge storage unit having an ink inducing member and a cover member is provided with a main body having an front face and a rear face, a sealing member connected to the front face, and a guiding protrusion arranged at the rear face. The cover member includes a pair of projections arranged at a location that corresponds to the guiding protrusion of the protection device. The width of the guiding protrusion is equal to or smaller than the width between the pair of projections, and the guiding protrusion is guided in between the pair of projections in the course of rotating the cover member to its closed state.
US07740336B2 Array type multi-pass inkjet printer and operating method thereof
An array type multi-pass inkjet printer head and an operating method thereof. The array type inkjet printer includes an image dividing unit to divide an image to be printed into a plurality of images, a printing unit having a head and to print one of the plurality of divided images on a printing medium using the head, the head being formed in a lateral direction and having a plurality of nozzles disposed in a longitudinal direction thereof, a feedback unit to reversely move the printing medium to a preceding end of the printing unit after the one of the plurality of divided images is printed by the printing unit, and a control unit to control the printing unit to print a divided image next to the printed one image on the reversely printing medium.
US07740333B2 Printhead, head cartridge, and printing apparatus using restriction circuit for restricting input of signals
A printhead tolerant of switching noise that occurs when concurrently driving plural printing elements, a head cartridge using the printhead, and a printing apparatus can be provided. The printhead includes plural printing elements and plural driving elements for driving the plural printing elements, and prints using these printing elements. The printhead also includes a shift register which receives print data in synchronism with a clock signal, and a latch circuit which latches the print data input to the shift register in synchronism with a latch signal. The printhead further includes a restriction circuit which restricts input of the print data and clock signal to the shift register and input of the latch signal to the latch circuit in synchronism with input of an enable signal for driving the plural driving elements.
US07740332B2 Device for fast displacement of the position in height of an internal shelf resting surface of an electrical household appliance, such as a refrigerator or freezer
A device for fast displacement of the position in height of a shelf within a refrigerating cell of an electrical household appliance, such as a refrigerator or freezer, includes elements for the coupling with respective guides for supporting the refrigerating cell arranged in a plurality of positions fixed in height within the refrigerating cell itself and adjustment elements set between the coupling elements and respective opposite lateral sides of the shelf for selective displacement of the shelf between a first position and a second position, set at different heights, with respect to the coupling elements; in this way, the resting shelf can be coupled in use with a pair of guides set at a selected height in the refrigerating cell and can be displaced between two different heights with respect to that of the pair of guides simply by pushing the shelf itself upwards.
US07740317B2 Lock apparatus of seat for vehicle
A lock apparatus of a seat for a vehicle includes a striker, a base including a first groove portion, a hook including a second groove portion and pivoting between a lock position and an unlock position, a pawl restraining a pivotal movement of the hook towards the unlock position while allowing the pivotal movement of the hook towards the lock position, a cam member including a cam profile for allowing the pivotal movement of the hook towards the lock position and for restraining the pivotal movement of the hook towards the unlock position, and a first biasing member. When the hook is pivoted to the lock position, the striker is positioned between the rotational shaft of the hook and the rotational shaft of the pawl, and the pawl and the hook are engaged at an opposite position of the rotational shaft of the hook relative to the striker.
US07740315B2 Back construction for seating unit
A chair includes a base having a control assembly operably supporting a seat assembly and also a back assembly for movement about a seat tilt axis and a back tilt axis, respectively. The back assembly includes a flexible sheet supported at upper/outer corners by a back support structure and hanging downwardly. The flexible sheet includes a lower portion coupled to the back support structure by a tensioner for holding the lower portion rearwardly. A vertically-adjustable lumbar mechanism is adjustably supported on the back support structure and operably engages the flexible sheet for flexing a lumbar area of the flexible sheet forwardly to provide an optimal ergonomic horizontal and vertical convex shape for postural lumbar support.
US07740314B2 Removeable car seat cover
A removable child car seat cover that enables removal of the cover without requiring that the car seat be removed from the car.
US07740313B1 Child restraint systems
Improvements for child restraint systems are directed specifically to the covers, handles, and harnesses thereof. A child restraint cover is readily removed without having to detach the harness from the seat. A soft and semi rigid child restraint handle includes members that are tied together in a crossover fashion. Another handle of the invention spans above the restraint in a head to foot direction. A further handle design includes dual integrated handles. 5-point and 7-point harnesses that do not require threading a child's limbs through harness loops are also provided. A harness height adjuster is also described.
US07740312B2 Portable drink holder with internal reader light
A drink holder assembly includes a drink holder which is mountable above a tray, such as an airline table tray mounted on the back of an airline chair. Typically, a support extends downwardly from the drink holder and a mounting mechanism connected to the support removably mounts the drink holder on the tray. A reading light is preferably mounted on the drink holder to provide light directed toward the tray. The assembly may include another light so that the assembly serves as a flashlight useful for emergency purposes. The assembly is collapsible to fit within a purse or briefcase. The drink holder may be spaced sufficiently above the tray to accommodate a laptop computer seated on the tray.
US07740310B1 Lawn chair with incorporated solar light protective device
A lawn chair with an incorporated solar light protective device that is designed to provide an outdoor place to sit down, while at the same time, provide a place to hide an individual from the potentially damaging rays of the sun. The device includes a sheet of flexible material, preferably canvas, that is mounted above a lawn chair. Some aspects of the sheet are adjustable to allow to be adjusted as needed for various users. The sheet is preferably placed over the head end of the lawn chair, protecting an individual's upper body while the individual is lying in the lawn chair.
US07740309B2 Folding chair
A folding chair utilizes a gear train to control a folding motion and to achieve a compact closed form. While holding a handle integrated into a backrest, the weight of the chair allows it to open and unfold automatically into an open position. The folding chair locks in place in the open position. To refold the chair, a button is depressed to release the lock and the seat is pulled toward the backrest. The gear train refolds the front and rear legs. In the compact folded position, the lightweight chair can be carried with one hand in a relaxed position, similar to an attache case. The handle is contoured so that it is possible for an adult to carry two chairs back to back in each hand.
US07740306B2 Stiffeners for utility trailer structural panels
A utility trailer structural panel (10) of the skin-stiffener type has a skin (15) supported by uniformly spaced stiffeners or roof bows (39). Stiffeners or roof bows (39) are secured to panel skin (15) and extend outwardly from the associated panel skin (15). Each stiffener (39) has central flange (35) from which extend webs (36, 37) to mounting flanges (41, 42). Mounting flanges (41, 42) have free edges and respective beads or curls (44, 46) formed thereon for stabilizing of flanges (41, 42) to improve load transfer at the interface between the roof bows (39) and the skin (15).
US07740299B2 Central console for a vehicle
A lid is formed with a domed underside that faces the internal space of a vehicle console. The console includes an operating mechanism disposed within an end face of the console basic body and that lies in a plane perpendicular to the pivot axis underneath the lid. The operating mechanism can be used universally both for individual lids as well as for lid wings. The operating mechanism requires as little usable space as possible to accommodate the operating mechanism.
US07740294B2 Protective vehicle cover
A vehicle protector having an elongated body with a front surface, a back surface, a top, a bottom, and a first and second end, the first and second ends disposed opposite from one another, with first and second top straps disposed on the front surface nearer to the top than the bottom, the first top strap having a distal end extending from the first body end and the second top strap having a distal end extending from the second body end. Upon the application of tensile forces to the first and second top straps and the first and second bottom straps, the top of the body is drawn towards the bottom of the body on the back surface.
US07740293B2 Combination bumper cover and stiffener for vehicles
A combination bumper cover and stiffener for vehicles maintains a good appearance and maximizes the absorption of shocks when a pedestrian is hit by the front of a vehicle. The combination bumper cover and stiffener includes a stiffener and a bumper cover. The stiffener includes a first mounting surface which contacts a front end module carrier of a vehicle, an extension surface which extends from the first mounting surface towards a front of the vehicle, and a second mounting surface which is formed by bending an edge of the extension surface towards a rear of the vehicle. The bumper cover is mounted at one surface thereof to the second mounting surface.
US07740292B1 Mechanical tamper-evident high security seal and method of use to secure a cargo container
A mechanical tamper evident security seal for sealing a cargo container door includes a metallic pin having a head at an upper end and circumferential indents at a second end. An upper banner includes a portion non-removably encasing the head of the metallic pin. The banner includes first identifying indicia unique to a particular one of a plurality of like mechanical seals. A lock receptacle receives the second end of the metallic pin therein and includes a lock housing retaining at least two locks therein. A first of the locks engaging a first of the circumferential indents and a second of the locks simultaneously engages a second of the circumferential indents. Any attempt to withdraw the metallic pin results in visually identifiable destruction of the seal. A lower banner extending from the lock receptacle includes second unalterable identifying indicia identical to the first identifying indicia. The seal is one element of a security seal tamper-evidencing kit providing a multi-layered approach to securing a cargo container.
US07740291B2 Door handle assembly
In at least one embodiment, a door handle assembly is provided. The door handle assembly includes a door handle and a mount. The door handle can be attached to the mount. The door handle is adapted to allow a bolt to move into and out of a wall aperture. A cam assembly is disposed adjacent the bolt. The cam assembly includes a locking cam. The locking cam is adapted to abut at least a portion of the bolt. The locking cam is moveable between a locked and an unlocked position. A lock release mechanism is coupled to the cam assembly and to the door handle. The lock release mechanism is adapted to disengage the locking cam from the bolt when the door handle is actuated such that the bolt is free to move.
US07740288B2 High-flow luer lock connector for a luer lock connection
A high-flow luer lock connector may include a connector body defining an interior region, a lumen, and an extended passageway. The interior region is bounded by a cylindrical side wall and a base wall. The lumen is defined at the base wall of the interior region and extends no more than 0.274 of an inch into the interior region. The extended passageway comprises a first and second end and passes through the connector body and the lumen. The extended passageway is in communication with the interior region to allow insufflation gas to flow through the interior region and extended passageway.
US07740287B2 Flexible joint for cryogenic pipe
A flexible joint for transfer of especially a cryogenic fluid includes a first element (3) and a second element (4). The first element (3) comprising an internal, partly curved surface (6), the second element (4) comprising a corresponding outer partly curved surface (8) with at least a sealing element (12,12′) between the curved surfaces (6,8). The first element (3) comprises a first connection part (9) and the second element comprises a second connection part (10) connectable to the first connection part (9) with a flexible part (11, 11′) between the connection of the two connectable parts (9,10) and the sealing element (12). Thereby it is formed a void (16) which may be pressurized with an inert gas at a pressure equal to or higher than the pressure of the fluid to be transferred through the joint.
US07740286B2 Rotary transmission leadthrough provided with a gas return line
A rotary transmission leadthrough is provided with a gas return line, in particular for filling a vehicle fuel tank comprising a rapid-action connection coupling, which is connected to the supply line and to a return line. The supply line and the return line are arranged in a coaxial manner in relation to each other.
US07740284B2 Vented gas riser apparatus
A vented gas riser for use in a system for conducting pressurized gas through a gas carrier pipe from a gas supply source line located below ground level to a delivery point disposed above ground is provided. A fluid tight gas riser protective casing is disposed around said carrier pipe and creates a gas escape passageway in an elongate annular space between the carrier pipe and the casing. A containment chamber is disposed below ground level which creates a confined space which has, as its only egress, a fluid connection to a gas escape passageway. Any gas which leaks into the containment chamber is directed into the gas escape passageway. A riser transition head, which includes at least one vent passageway, provides a fluid connection with said gas escape passageway and with the atmosphere such that any gas which leaks into said containment chamber is directed through the gas escape passageway and through the at least one vent and into the atmosphere.
US07740283B2 Tube fitting with separable tube gripping device
A tube fitting for a tube end has a female member that cooperates with a male member. A tube gripping device in the form of a gripping ring or ferrule is retained with the female member. Upon a partial pull-up, the tube gripping device separates from the female member.
US07740282B2 Port identification system and method
A cable port identification system is disclosed that provides identification facilities for communication, data, other cabling and/or wires and the connectors to which they are coupled found in a multi-port station. In some implementations the identification facilities can include label retention and protection and may also include label magnification.
US07740280B1 Substrate labeling system
In an embodiment, there is disclosed a product labeling system comprising: a first high energy electromagnetic or particle wave generator, at least one second high energy electromagnetic of particle wave generator; and a controller operatively configured to direct wave produced by said first generator and the wave produced by said second generator onto a portion of the subsurface of the product to mark the product at said subsurface without generating any substantial disruption of the surface of said product.
US07740276B2 Window restraint device
A window restraint device includes a mesh screen having an upper end and a lower end. The restraint device includes an upper attachment device, such as a clip or strap, coupled to the screen upper end for removable attachment to an automobile door frame. The restraint device also includes a lower attachment device, such as a suction cup, coupled to the screen lower end for connecting the lower end of the screen to an automobile window. Neither the upper or lower attachment devices interfere with normal operation of the vehicle window, nor do they restrict a pet from normal movement within the vehicle. The restraint device may also include a spring-loaded reel from which the screen may be extended from or retracted into. The spring provides tension between upper and lower ends of the screen.