预测肝癌预后的组合物或试剂盒以及预测肝癌预后的方法专利检索-免疫吸附疗法专利检索查询-专利查询网

预测肝癌预后的组合物或 试剂盒以及预测肝癌预后的方法

阅读：70发布：2021-08-14

专利汇可以提供预测肝癌预后的组合物或试剂盒以及预测肝癌预后的方法专利检索，专利查询，专利分析的服务。并且本发明提供用于获得肝癌预后的标志物、用于获得肝癌预后的组合物或试剂盒以及用于获得肝癌预后的方法，所述组合物或试剂盒优选是能够在各个分期获得肝癌预后的肝癌预后组合物或试剂盒。本发明的标志物、组合物或试剂盒以及方法能够有效地获得肝癌预后、优选在各个分期有效地获得肝癌预后。，下面是预测肝癌预后的组合物或试剂盒以及预测肝癌预后的方法专利的具体信息内容。

权利要求

1.一种用于预测肝癌预后的组合物或试剂盒，所述组合物或试剂盒包含：
对选自下表所示的组的一种或至少两种基因中的每一种分别具有特异性的核酸，或对所述基因编码的蛋白有特异性的抗体；并且
所述组合物或试剂盒用于根据选自A1组、A2组、B组或C组的一个或多个组中的分
期来预测肝癌预后；其中A1组为门静脉侵袭阴性患者组，患者处于BCLC(巴塞罗那临床肝癌)分期系统的0期或A期，具有1个尺寸为5cm以下的肿瘤或3个以下的尺寸为3cm以下的肿瘤；A2组为门静脉侵袭阴性患者组，患者具有尺寸大于5cm的肿瘤；B组为门静脉侵袭阴性患者组，患者处于BCLC分期系统的中期，具有多个尺寸大于3cm的肿瘤或数量大于
3的多个肿瘤；C组为门静脉侵袭阳性患者组，不论肿瘤尺寸和数量如何：
[表1]
2.如权利要求1所述的组合物或试剂盒，其中，由基因组成的所述组是由下表所示的基因组成的组：
[表2]
3.如权利要求2所述的组合物或试剂盒，其中，由基因组成的所述组还包含下表所示的基因：
[表3]
4.如权利要求1所述的组合物或试剂盒，其中，所述预后是对复发、存活或无病存活的预测。
5.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测A1组的复发预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表4]
一种两种的组合三种的组合四种的组合
BCL2L1 FRAP1_SESN1 FRAP1_CASP3_CDH2 ID2_NAMPT_RPS19BP1_SESN3
BECN1 FRAP1_TWIST1 ID2_CDH2_SESN3 FRAP1_LC3_CASP3_CDH2
BAX FRAP1_CASP3 FRAP1_CDH2_SESN1 FRAP1_TKT_CASP3_CDH2
CDH2 FRAP1_CCNG2 FRAP1_LC3_CASP3 BAX_FRAP1_LC3_CDH2
NAMPT BAX_FRAP1 FRAP1_LC3_TWIST1 ID2_CDH2_NAMPT_SESN3
TWIST1 FRAP1_NNMT BAX_FRAP1_LC3 CBS_ID2_CDH2_SESN3
RPS19BP1 BCL2L1_FRAP1 FRAP1_CDH2_TWIST1 FRAP1_LC3_CDH2_KIAA1967
MMP2 AIFM1_FRAP1 FRAP1_NNMT_CDH2 FRAP1_CDH2_SESN1_STAT3
SESN3 FRAP1_RAGE FRAP1_LC3_NNMT FRAP1_LC3_NNMT_CDH2
ID2 FRAP1_VEGF BAX_FRAP1_CDH2 FRAP1_LC3_CDH2_RAPTOR
AGER ID2_CDH2 FRAP1_SESN1_STAT3 ID2_CDH2_RPS19BP1_SESN3
ATG12 FRAP1_PTEN AIFM1_FRAP1_CDH2 FRAP1_LC3_CDH2_TWIST1
NAMPT_SESN3 FRAP1_LC3_VEGF FRAP1_LC3_CDH2_VEGF
BCL2_FRAP1 FRAP1_NNMT_MMP2 FRAP1_LC3_SESN1_STAT3
CDH2_SESN3 FRAP1_LC3_RAGE FRAP1_LC3_CDH2_RAGE
FRAP1_RAPTOR FRAP1_CCNG2_CDH2 FRAP1_LC3_NNMT_STAT3
FRAP1_KIAA1967 BCL2L1_FRAP1_CDH2 ID2_CDH2_MMP2_SESN3
FRAP1_XIAP FRAP1_CDH2_VEGF FRAP1_LC3_CASP3_STAT3
BECN1_SESN3 FRAP1_LC3_CCNG2 AIFM1_FRAP1_LC3_CDH2
HMGB1_TWIST1 FRAP1_CASP3_MMP2 BCL2L1_FRAP1_LC3_CDH2
ID2_NAMPT BCL2L1_FRAP1_LC3 FRAP1_LC3_PTEN_CDH2
FRAP1_PRKAA1 FRAP1_LC3_SESN1 BAX_FRAP1_LC3_BECN1
ID2_RPS19BP1 FRAP1_CDH2_KIAA1967 BAX_FRAP1_LC3_RPS19BP1
BAX_LC3 AIFM1_FRAP1_LC3 FRAP1_CASP3_CDH2_STAT3
FRAP1_TP63 FRAP1_LC3_RAPTOR LC3_HMGB1_STAT3_TWIST1
ATG12_SESN3 FRAP1_CDH2_RAGE BAX_FRAP1_TKT_CDH2
BAX_TWIST1 BAX_FRAP1_MMP2 FRAP1_LC3_CCNG2_CDH2
RPS19BP1_SESN3 FRAP1_LC3_PTEN FRAP1_TKT_CDH2_SESN1
BAX_MMP2 FRAP1_TKT_CASP3 FRAP1_LC3_HMGB1_TWIST1
SESN1_STAT3 FRAP1_PTEN_CDH2 FRAP1_NNMT_TKT_CDH2
LC3_TWIST1 FRAP1_TKT_TWIST1 BAX_FRAP1_LC3_MMP2
MMP2_NAMPT FRAP1_LC3_KIAA1967 FRAP1_LC3_CCNG2_STAT3
ID2_BECN1 BAX_FRAP1_TKT FRAP1_LC3_STAT3_TWIST1
BCL2L1_LC3 BCL2_FRAP1_CDH2 FRAP1_TKT_CDH2_TWIST1
MMP2_RPS19BP1 FRAP1_HMGB1_TWIST1 FRAP1_LC3_NNMT_MMP2
ATG7_BCL2L1 FRAP1_RPS19BP1_TWIST1 BAX_FRAP1_TKT_MMP2
ID2_TWIST1 FRAP1_CDH2_RAPTOR FRAP1_NNMT_CDH2_MMP2
CDH2_HMGB1 FRAP1_TKT_SESN1 FRAP1_LC3_CDH2_SESN1
CDH2_MMP2 FRAP1_RPS19BP1_SESN1 BAX_FRAP1_LC3_TKT
ATG7_TWIST1 BAX_FRAP1_BECN1 FAS_FRAP1_CDH2_SESN1
BAX_SESN3 ID2_NAMPT_SESN3 BAX_FAS_FRAP1_LC3
FASLG_NAMPT FRAP1_CCNG2_STAT3 FRAP1_CASP3_CDH2_MMP2
ATG7_BAX BCL2L1_FRAP1_MMP2 ID2_FASLG_NAMPT_SESN3
TKT_NAMPT BCL2_FRAP1_LC3 FRAP1_ID2_CDH2_TWIST1
STAT3_TWIST1 FASLG_NAMPT_SESN3 FRAP1_CDH2_HMGB1_TWIST1
BCL2L1_MMP2 AIFM1_FRAP1_MMP2 BAX_FRAP1_BECN1_CDH2
LC3_KIAA1967 FRAP1_CCNG2_RPS19BP1 DRAM_ID2_CDH2_SESN3
BAX_BECN1 BAX_FRAP1_RPS19BP1 FRAP1_LC3_RPS19BP1_TWIST1
ATG12_ID2 FAS_FRAP1_SESN1 AIFM1_FRAP1_TKT_CDH2
BECN1_MMP2 BCL2L1_FRAP1_TKT FRAP1_TKT_CCNG2_CDH2
AKT1_BAX FRAP1_NNMT_STAT3 BCL2L1_FRAP1_TKT_CDH2
LC3_RAPTOR FRAP1_MMP2_SESN1 DIABLO_ID2_CDH2_SESN3
BAX_RPS19BP1 FRAP1_ID2_TWIST1 BCL2_FRAP1_LC3_CDH2
BAX_TKT FRAP1_CASP3_STAT3 FRAP1_LC3_CASP3_FASLG
BAX_SATB1 FRAP1_TKT_CCNG2 FRAP1_CDH2_RPS19BP1_SESN1
LC3_NAMPT FRAP1_MMP2_VEGF FRAP1_LC3_CASP3_MMP2
KIAA1967_MMP2 FRAP1_MMP2_RAPTOR ID2_CDH2_HMGB2_SESN3
CDH1_ID2_MMP9_TCF3
五种的组合六种的组合
FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_LC3_BECN1_CASP3_CDH2_STAT3
ID2_MMP2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_NNMT_BECN1_CDH2_STAT3
FRAP1_LC3_CDH2_SESN1_STAT3 FRAP1_LC3_TKT_CASP3_CDH2_STAT3
ID2_CDH2_MMP2_RPS19BP1_SESN3 ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3
FRAP1_LC3_NNMT_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_SESN1_STAT3
BAX_FRAP1_LC3_BECN1_CDH2 ID2_CDH2_FASLG_NAMPT_RPS19BP1_SESN3
ID2_FASLG_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_CASP3_CDH2_HMGB1_STAT3
BAX_FRAP1_LC3_TKT_CDH2 FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3
FRAP1_LC3_BECN1_CDH2_RAPTOR FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3
FRAP1_LC3_CDH2_STAT3_TWIST1 FRAP1_LC3_CDH2_HMGB1_STAT3_TWIST1
FRAP1_LC3_CCNG2_CDH2_STAT3 ID2_HMGB2_MMP2_NAMPT_RPS19BP1_SESN3
ID2_CDH2_FASLG_NAMPT_SESN3 AIFM1_FRAP1_LC3_BECN1_CDH2_STAT3
LC3_CDH2_HMGB1_STAT3_TWIST1 ID2_MMP2_NAMPT_RPS19BP1_SESN3_STAT3
ID2_CDH2_HMGB1_RPS19BP1_SESN3 ID2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3
ID2_CDH2_MMP2_NAMPT_SESN3 AKT1_FAS_BECN1_CDH2_STAT3_TP63
FRAP1_LC3_BECN1_CDH2_KIAA1967 FRAP1_LC3_CCNG2_CDH2_RPS19BP1_STAT3
BAX_FRAP1_LC3_CDH2_RPS19BP1 AKT1_ATG12_BECN1_CDH2_STAT3_TP63
ID2_HMGB2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3
ID2_NAMPT_RPS19BP1_SESN3_STAT3 CSE1L_FRAP1_LC3_CASP3_CDH2_STAT3
FRAP1_LC3_CDH2_HMGB1_TWIST1 FRAP1_LC3_BECN1_CDH2_RAGE_STAT3
FRAP1_TKT_CDH2_SESN1_STAT3 FAS_FRAP1_LC3_NNMT_CDH2_STAT3
CSE1L_ID2_CDH2_RPS19BP1_SESN3 ID2_HMGB1_MMP2_NAMPT_RPS19BP1_SESN3
FRAP1_LC3_TKT_CASP3_CDH2 FRAP1_LC3_TKT_CDH2_SESN1_STAT3
BAX_FAS_FRAP1_LC3_CDH2 FRAP1_LC3_NNMT_CDH2_MMP2_STAT3
FAS_FRAP1_LC3_CDH2_RAPTOR FRAP1_LC3_NNMT_TKT_CDH2_STAT3
LC3_CASP3_CDH2_HMGB1_STAT3 BAX_FRAP1_LC3_BECN1_CDH2_STAT3
FAS_FRAP1_LC3_CDH2_KIAA1967 FRAP1_LC3_CASP3_CDH2_SIRT1_STAT3
AIFM1_FRAP1_LC3_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR_RPS19BP1
FRAP1_LC3_BECN1_CASP3_STAT3 CBS_FRAP1_LC3_CASP3_CDH2_STAT3
FRAP1_BECN1_CASP3_CDH2_STAT3 FAS_FRAP1_LC3_CASP3_CDH2_STAT3
ID2_CDH2_NAMPT_SESN3_STAT3 AKT1_ATG12_FAS_CDH2_STAT3_TP63
LC3_ID2_NAMPT_RPS19BP1_SESN3 LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1
FRAP1_LC3_NNMT_MMP2_STAT3 FRAP1_LC3_BECN1_CDH2_STAT3_TWIST1
BAX_FRAP1_LC3_CASP3_CDH2 FRAP1_LC3_CASP3_CDH2_MMP2_STAT3
FRAP1_TKT_CASP3_CDH2_STAT3 ID2_MMP9_MMP2_NAMPT_RPS19BP1_SESN3
LC3_HMGB1_RPS19BP1_STAT3_TWIST1 CSE1L_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_CDH2_RPS19BP1_SESN1_STAT3 FRAP1_LC3_BECN1_CDH2_STAT3_VEGF
CBS_FRAP1_LC3_CASP3_CDH2 BAX_FRAP1_LC3_TKT_BECN1_CDH2
FRAP1_LAMP1_TKT_CASP3_CDH2 FRAP1_LC3_NNMT_CASP3_CDH2_STAT3
ID2_CDH2_HMGB1_NAMPT_SESN3 FRAP1_TKT_BECN1_CASP3_CDH2_STAT3
ID2_HMGB1_NAMPT_RPS19BP1_SESN3 ID2_FASLG_NAMPT_RPS19BP1_SESN3_STAT3
AKT1_ID2_NAMPT_RPS19BP1_SESN3 FAS_FRAP1_LC3_CDH2_KIAA1967_RPS19BP1
FRAP1_LC3_TKT_CDH2_KIAA1967 FRAP1_LC3_BECN1_CDH2_SESN1_STAT3
FRAP1_LC3_CASP3_CDH2_HMGB1 ID2_CDH2_FASLG_NAMPT_SESN3_STAT3
ATG7_FRAP1_LC3_CASP3_CDH2 FRAP1_LC3_TKT_CDH2_STAT3_TWIST1
BAX_FRAP1_LC3_TKT_MMP2 ATG5_FRAP1_LC3_CASP3_CDH2_STAT3
FRAP1_LC3_CDH2_RAPTOR_RPS19BP1 ID2_CDH2_MMP2_RPS19BP1_SESN3_STAT3
FRAP1_LC3_RPS19BP1_SESN1_STAT3 FAS_LC3_CDH2_HMGB1_STAT3_TWIST1
BAX_FRAP1_LC3_CDH2_MMP2 AIFM1_FRAP1_LC3_TKT_CDH2_STAT3
ID2_TCF3_CDH2_RPS19BP1_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_FASLG
FRAP1_TKT_CASP3_CDH2_FASLG DRAM_ID2_MMP2_NAMPT_RPS19BP1_SESN3
FAS_FRAP1_CDH2_SESN1_STAT3 FRAP1_LC3_CASP3_CDH2_NAMPT_STAT3
CBS_ID2_NAMPT_RPS19BP1_SESN3 FAS_FRAP1_LC3_CCNG2_CDH2_STAT3
FRAP1_LC3_CDH2_KIAA1967_MMP2 BAX_FAS_FRAP1_LC3_CDH2_RPS19BP1
FAS_FRAP1_LC3_CASP3_CDH2 BNIP3_FRAP1_LC3_CASP3_CDH2_STAT3
BAX_CBS_FRAP1_LC3_CDH2 FRAP1_LC3_CDH2_RPS19BP1_STAT3_TWIST1
FRAP1_LC3_TKT_CDH2_RAPTOR FRAP1_LC3_MMP9_CASP3_CDH2_STAT3
CDH1_ID2_MMP9_TCF3_RPS19BP1 CDH1_ID2_MMP9_TCF3_RPS19BP1_SESN3
七种的组合八种的组合
AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63ID2_CDH2_FASLG_NAMPT_RPS19BP1_SESN3_STAT3 AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63FRAP1_LC3_NNMT_TKT_BECN1_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63AKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 FAS_FRAP1_LC3_BECN1_CASP3_CDH2_RPS19BP1_STAT3FAS_FRAP1_LC3_CCNG2_CDH2_RPS19BP1_STAT3 AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63FRAP1_LC3_BECN1_CASP3_CDH2_HMGB1_STAT3 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_FASLG_STAT3ID2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3_STAT3 CSE1L_FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3FRAP1_LC3_NNMT_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63CBS_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 FAS_FRAP1_LC3_NNMT_BECN1_CDH2_RPS19BP1_STAT3FRAP1_LC3_BECN1_CASP3_CDH2_SIRT1_STAT3 AKT1_CASP8_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63CSE1L_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 FRAP1_LC3_NNMT_TKT_BECN1_CDH2_FASLG_STAT3FRAP1_LC3_TKT_CASP3_CDH2_HMGB1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63FRAP1_LC3_TKT_CDH2_HMGB1_STAT3_TWIST1 AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63ATG5_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63CSE1L_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 ID2_CDH2_FASLG_HMGB1_HMGB2_NAMPT_RPS19BP1_SESN3FRAP1_LC3_BECN1_CASP3_CDH2_HMGB2_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_CIAP2_STAT3_TP63AKT1_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_CDH2_MMP2_RAPTOR_RPS19BP1 ID2_CDH2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3_STAT3AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63FRAP1_LC3_BECN1_CASP3_CDH2_FASLG_STAT3 AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3 AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RPS19BP1_SESN2_STAT3_TP63FAS_FRAP1_LC3_TKT_CDH2_SESN1_STAT3 AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63CBS_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 AKT1_LC3_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63FRAP1_LC3_BECN1_CDH2_HMGB1_STAT3_TWIST1 FAS_FRAP1_LC3_CASP3_CDH2_FASLG_RPS19BP1_STAT3CSE1L_FRAP1_LC3_TKT_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_CASP3_CDH2_STAT3_TP63FRAP1_LC3_NNMT_BECN1_CDH2_SIRT1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_HMGB2_STAT3_TP63AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63ID2_CDH2_FASLG_HMGB1_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_FASLG_HMGB1_STAT3ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3_STAT3 FAS_FRAP1_LC3_NNMT_CDH2_MMP2_RPS19BP1_STAT3FRAP1_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 FAS_FRAP1_LC3_BECN1_CDH2_RPS19BP1_SESN1_STAT3FAS_FRAP1_LC3_CDH2_KIAA1967_MMP2_RPS19BP1 FAS_FRAP1_LC3_TKT_CDH2_RPS19BP1_SESN1_STAT3FRAP1_LC3_BECN1_CASP3_CDH2_RPS19BP1_STAT3 AKT1_ATG12_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63FRAP1_LC3_TKT_CASP3_CDH2_FASLG_STAT3 AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63BNIP3_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63FRAP1_LC3_CASP3_CDH2_HMGB1_MMP2_STAT3 FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_SIRT1_STAT3FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 FAS_FRAP1_LC3_CDH2_FASLG_RPS19BP1_SESN1_STAT3ID2_HMGB1_HMGB2_MMP2_NAMPT_RPS19BP1_SESN3 AKT1_FAS_NNMT_BECN1_CDH2_RPS19BP1_STAT3_TP63FRAP1_LC3_TKT_BECN1_CDH2_FASLG_RAPTOR CSE1L_FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3FRAP1_LC3_NNMT_BECN1_CDH2_FASLG_STAT3 FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTOR_RPS19BP1FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1 AKT1_FAS_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63FRAP1_LC3_MMP9_BECN1_CASP3_CDH2_STAT3 FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63_TWIST1FAS_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 FAS_FRAP1_LC3_TKT_CASP3_CDH2_RPS19BP1_STAT3AIFM1_FAS_FRAP1_LC3_CDH2_RPS19BP1_STAT3 ID2_CDH2_FASLG_HMGB1_NAMPT_RPS19BP1_SESN3_STAT3AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63 FAS_FRAP1_LC3_BECN1_CDH2_FASLG_RAPTOR_RPS19BP1AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 CSE1L_FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3ID2_CDH2_HMGB1_MMP2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_HMGB1_STAT3AKT1_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_BECN1_CCNG2_CDH2_RPS19BP1_STAT3AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 FAS_FRAP1_LC3_TKT_BECN1_CDH2_FASLG_RAPTORATG5_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 AKT1_ATG12_FAS_TKT_BECN1_CDH2_STAT3_TP63FRAP1_LC3_CASP3_CDH2_HMGB1_RPS19BP1_STAT3 FRAP1_LC3_BECN1_CASP3_CDH2_FASLG_HMGB1_STAT3CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3 CDH1_ID2_MMP9_TCF3_CDH2_MMP2_RPS19BP1_SESN3。
6.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测A1组的存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表5]
一种两种的组合三种的组合四种的组合
ID2 CDH1_ID2 ATG12_CDH1_ID2 ATG12_CDH1_ID2_HMGB2
CDH1 ATG12_CDH1 CDH1_ID2_HMGB2 CDH1_ID2_AGER_HMGB2
LC3 LAMP1_ID2 ATG12_CDH1_HMGB2 ATG12_CDH1_ID2_AGER
TKT BNIP3_ID2 CDH1_ID2_AGER ATG12_CDH1_TCF3_HMGB2
AKT1 ATG12_ID2 DRAM_CDH1_ID2 ATG12_DRAM_CDH1_ID2
AIFM1 CDH1_HMGB2 E2F1_CDH1_ID2 AIFM1_CASP8_LC3_CDH1
BNIP3 ID2_HMGB2 CDH1_ID2_LAMP2 ATG12_CDH1_AGER_HMGB2
LAMP1 E2F1_ID2 TKT_CDH1_ID2 ATG12_CDH1_ID2_BECN1
FRAP1 TKT_ID2 LAMP1_CDH1_ID2 ATG12_DRAM_CDH1_HMGB2
DRAM_ID2 CDH1_ID2_MMP2 DRAM_CDH1_ID2_HMGB2
ATG5_ID2 ATG12_DRAM_CDH1 ATG12_CDH1_BHLHE41_HMGB2
ID2_BECN1 CSE1L_CDH1_ID2 CDH1_ID2_HMGB2_LAMP2
ID2_AGER CDH1_ID2_MMP9 ATG12_CDH1_BECN1_HMGB2
ID2_MMP2 BNIP3_CDH1_ID2 E2F1_CDH1_ID2_HMGB2
ATG3_ID2 CDH1_ID2_BECN1 ATG12_DIABLO_CDH1_BHLHE41
ID2_LAMP2 ATG12_CDH1_BHLHE41 CDH1_ID2_BECN1_HMGB2
ULK1_CDH1 ULK1_CDH1_ID2 ATG12_ATG5_CDH1_HMGB2
CSE1L_ID2 LC3_CDH1_ID2 DRAM_CDH1_ID2_AGER
TKT_CDH1 ATG12_CDH1_TCF3 LAMP1_CDH1_ID2_HMGB2
LC3_CDH1 ATG5_CDH1_ID2 ATG12_BNIP3_CDH1_ID2
ID2_MMP9 ATG3_CDH1_ID2 ATG12_CSE1L_CDH1_ID2
LC3_ID2 DIABLO_CDH1_ID2 ATG12_CDH1_ID2_MMP2
FRAP1_ID2 CASP8_CDH1_ID2 ATG12_CASP8_CDH1_ID2
CASP8_ID2 ATG12_ULK1_CDH1 ATG12_ATG3_CDH1_HMGB2
ID2_CIAP2 ATG12_CDH1_BECN1 ATG12_CDH1_ID2_MMP9
ID2_UVRAG ATG12_BNIP3_ID2 CDH1_ID2_HMGB2_MMP2
DIABLO_ID2 CDH1_ID2_CIAP2 ATG12_ATG3_CDH1_ID2
DRAM_CDH1 CBS_CDH1_ID2 ATG12_CASP8_CDH1_HMGB2
ID2_SIRT1 CDH1_ID2_HMGB1 ATG12_LAMP1_CDH1_ID2
FAS_ID2 CDH1_ID2_SIRT1 CDH1_ID2_AGER_BECN1
CDH1_AGER LAMP1_ID2_HMGB2 ATG12_FAS_CDH1_HMGB2
ID2_STAT3 CDH1_ID2_UVRAG ATG12_TKT_CDH1_ID2
CBS_ID2 AIFM1_LC3_CDH1 CDH1_ID2_MMP9_HMGB2
CDH1_MMP2 ATG12_CDH1_AGER ATG12_CDH1_HMGB1_HMGB2
AKT1_ID2 CDH1_ID2_STAT3 ATG12_CDH1_MMP9_HMGB2
ID2_CDH2 ATG12_LAMP1_ID2 ATG12_ATG5_CDH1_ID2
ATG7_ID2 ATG12_LC3_CDH1 ATG5_CDH1_ID2_HMGB2
ID2_HMGB1 CDH1_AGER_HMGB2 ATG3_CDH1_ID2_HMGB2
ULK1_ID2 FAS_CDH1_ID2 ATG12_DIABLO_CDH1_ID2
CDH1_LAMP2 ATG7_CDH1_ID2 CSE1L_CDH1_ID2_HMGB2
ATG5_CDH1 ATG12_CDH1_MMP2 ATG12_CDH1_CIAP2_HMGB2
ID2_SATB1 ATG12_CASP8_CDH1 ATG12_CDH1_ID2_UVRAG
CDH1_MMP9 ATG12_TKT_CDH1 ATG12_CDH1_HMGB2_SESN3
ID2_RPS19BP1 BNIP3_ID2_HMGB2 LC3_CDH1_ID2_AGER
ID2_TCF3 E2F1_ID2_HMGB2 ATG12_CDH1_HMGB2_SIRT1
CSE1L_CDH1 ATG12_CDH1_MMP9 ATG12_E2F1_CDH1_ID2
AIFM1_CDH1 ATG12_CDH1_SESN2 ATG12_FAS_CDH1_ID2
ID2_SESN3 CDH1_ID2_CDH2 AIFM1_ATG3_LC3_CDH1
ID2_SESN2 AKT1_CDH1_ID2 ATG12_CDH1_HMGB2_MMP2
LAMP1_CDH1 LAMP1_ID2_BECN1 BNIP3_CDH1_ID2_HMGB2
AIFM1_LC3 CDH1_ID2_TCF3 ATG12_ULK1_CDH1_HMGB2
E2F1_CDH1 ATG12_CDH1_UVRAG TKT_CDH1_ID2_HMGB2
ID2_NAMPT ATG12_FAS_CDH1 ATG12_CDH1_ID2_LAMP2
DIABLO_CDH1 LAMP1_TKT_ID2 ATG12_LC3_CDH1_ID2
BNIP3_CDH1 LAMP1_ID2_AGER ATG12_CDH1_HMGB2_UVRAG
AKT1_CDH1 DRAM_LAMP1_ID2 CASP8_CDH1_ID2_HMGB2
CASP8_CDH1 ATG12_DIABLO_CDH1 DIABLO_CDH1_ID2_HMGB2
CDH1_ID2_MMP9_TCF3
五种的组合六种的组合
ATG12_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_HMGB2
ATG12_DRAM_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_AGER_BECN1_HMGB2
DRAM_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_BECN1_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_RPS19BP1
ATG12_LAMP1_CDH1_ID2_HMGB2 ATG12_LAMP1_CDH1_ID2_AGER_HMGB2
ATG12_ATG5_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_MMP9_AGER_HMGB2
ATG12_E2F1_CDH1_ID2_HMGB2 ATG12_ATG3_CDH1_ID2_AGER_HMGB2
ATG12_ATG3_CDH1_ID2_HMGB2 ATG12_LC3_CDH1_ID2_AGER_HMGB2
CDH1_ID2_AGER_BECN1_HMGB2 ATG12_BNIP3_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_HMGB2_MMP2 ATG12_CDH1_ID2_AGER_HMGB2_SIRT1
ATG12_CASP8_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_MMP2
ATG12_BNIP3_CDH1_ID2_HMGB2 ATG12_CASP8_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_MMP9_HMGB2 ATG12_CDH1_ID2_AGER_CIAP2_HMGB2
LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_ATG5_CDH1_ID2_AGER_HMGB2
ATG12_CSE1L_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_TCF3_AGER_HMGB2
LC3_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_BECN1_HMGB2
ATG12_DIABLO_CDH1_ID2_HMGB2 ATG12_FAS_CDH1_ID2_AGER_HMGB2
CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_AGER_HMGB1_HMGB2
CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_HMGB2
CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_ATG3_DRAM_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_CIAP2_HMGB2 ATG12_ATG5_DRAM_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_HMGB2_UVRAG ATG12_DIABLO_CDH1_ID2_AGER_HMGB2
ATG12_DRAM_CDH1_ID2_AGER ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2
ATG12_DRAM_CDH1_TCF3_HMGB2 ATG12_CASP8_DRAM_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_AGER_BECN1 ATG12_DRAM_CDH1_ID2_HMGB2_MMP2
ATG12_DIABLO_CDH1_BHLHE41_HMGB2 ATG12_LAMP1_CDH1_ID2_BECN1_HMGB2
ATG12_DIABLO_CDH1_HMGB2_SESN3 ATG12_CBS_CDH1_ID2_AGER_HMGB2
ATG12_FAS_CDH1_ID2_HMGB2 ATG12_DRAM_CDH1_ID2_MMP9_HMGB2
ATG3_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_UVRAG
CDH1_ID2_AGER_HMGB2_MMP2 ATG12_E2F1_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_TCF3_HMGB2 ATG12_ATG5_CDH1_ID2_BECN1_HMGB2
ATG12_CDH1_TCF3_AGER_HMGB2 ATG12_DIABLO_CDH1_CIAP2_HMGB2_SESN3
ATG12_CDH1_ID2_HMGB1_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_HMGB2
AIFM1_ATG3_CASP8_LC3_CDH1 ATG12_DRAM_E2F1_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_HMGB2_SIRT1 ATG12_DIABLO_CDH1_TCF3_HMGB2_SESN3
ATG12_CDH1_TCF3_BECN1_HMGB2 AIFM1_ATG3_ATG5_CASP8_LC3_CDH1
ATG12_DIABLO_CDH1_TCF3_BHLHE41 ATG12_BNIP3_DRAM_CDH1_ID2_HMGB2
BNIP3_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_CDH1_ID2_HMGB2_SESN3
AIFM1_CASP8_DRAM_LC3_CDH1 AIFM1_ATG3_CASP8_LC3_CDH1_MMP9
ATG12_CDH1_ID2_HMGB2_LAMP2 ATG12_ATG3_CDH1_ID2_BECN1_HMGB2
ATG12_ATG3_CDH1_TCF3_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_STAT3
ATG12_LC3_CDH1_ID2_HMGB2 ATG12_DIABLO_DRAM_CDH1_ID2_HMGB2
ATG12_TKT_CDH1_ID2_HMGB2 ATG12_DRAM_CDH1_ID2_CIAP2_HMGB2
CASP8_CDH1_ID2_AGER_HMGB2 DRAM_LAMP1_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_TCF3_BHLHE41_HMGB2 DRAM_CDH1_ID2_AGER_BECN1_HMGB2
ATG5_CDH1_ID2_AGER_HMGB2 ATG12_BNIP3_CDH1_ID2_HMGB2_MMP2
ATG12_CSE1L_CDH1_ID2_AGER ATG12_BNIP3_CDH1_ID2_BECN1_HMGB2
CDH1_ID2_AGER_HMGB2_SIRT1 ATG12_CSE1L_CDH1_ID2_BECN1_HMGB2
CDH1_ID2_AGER_CIAP2_HMGB2 LAMP1_LC3_CDH1_ID2_AGER_HMGB2
CDH1_ID2_TCF3_AGER_HMGB2 ATG12_CDH1_ID2_BECN1_HMGB2_MMP2
AIFM1_CASP8_LC3_CDH1_MMP9 DRAM_LC3_CDH1_ID2_AGER_HMGB2
ATG12_DRAM_CDH1_ID2_BECN1 ATG12_DIABLO_CDH1_BHLHE41_HMGB2_SIRT1
AIFM1_CASP8_DIABLO_LC3_CDH1 ATG12_TKT_CDH1_ID2_AGER_HMGB2
CDH1_ID2_AGER_HMGB1_HMGB2 DRAM_CDH1_ID2_MMP9_AGER_HMGB2
ATG12_CDH1_ID2_HMGB2_RPS19BP1 ATG12_CDH1_ID2_MMP9_BECN1_HMGB2
ATG12_LC3_CDH1_AGER_HMGB2 CSE1L_DRAM_CDH1_ID2_AGER_HMGB2
FAS_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_FAS_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_MMP9_TCF3 ATG12_CDH1_ID2_MMP9_TCF3_HMGB2
七种的组合八种的组合
ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_ATG3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_DRAM_CDH1_TCF3_CIAP2_HMGB2_SESN3ATG12_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 ATG12_BNIP3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1ATG12_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_AGER_BECN1_HMGB2ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_DRAM_CDH1_TCF3_BHLHE41_HMGB2_SIRT1ATG12_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_DIABLO_CDH1_TCF3_BECN1_CIAP2_HMGB2_SESN3ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_LAMP1_LC3_CDH1_ID2_AGER_BECN1_HMGB2ATG12_LC3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1ATG12_DRAM_LC3_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2ATG12_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_LC3_CDH1_ID2_AGER_BECN1_HMGB2ATG12_DRAM_CDH1_ID2_AGER_HMGB2_SIRT1 ATG12_ATG3_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_MMP9_AGER_BECN1_HMGB2ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 ATG12_CASP8_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_LAMP1_LC3_CDH1_ID2_AGER_HMGB2ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_CDH1_TCF3_BECN1_BHLHE41_HMGB2_SIRT1ATG12_DRAM_CDH1_ID2_AGER_CIAP2_HMGB2 ATG12_CSE1L_LC3_CDH1_ID2_AGER_BECN1_HMGB2ATG12_LAMP1_LC3_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1ATG12_CASP8_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_TCF3_AGER_BECN1_HMGB2ATG12_CSE1L_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SESN2_SIRT1ATG12_BNIP3_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_ATG5_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 ATG12_ATG3_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2ATG12_CDH1_ID2_AGER_BECN1_HMGB2_MMP2 ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2_MMP2ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_MMP9_AGER_HMGB2ATG12_ATG3_CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2_RPS19BP1ATG12_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3 ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2 ATG12_CSE1L_CDH1_ID2_MMP9_AGER_BECN1_HMGB2ATG12_ATG3_DIABLO_CDH1_TCF3_HMGB2_SESN3 ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1ATG12_CSE1L_LC3_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_FAS_CDH1_TCF3_BECN1_BHLHE41_HMGB2ATG12_CSE1L_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_CSE1L_DRAM_LC3_CDH1_ID2_AGER_HMGB2ATG12_ATG5_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2ATG12_DRAM_CDH1_ID2_AGER_HMGB1_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_MMP2ATG12_DRAM_LAMP1_CDH1_ID2_BECN1_HMGB2 ATG12_ATG3_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2ATG12_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1 ATG12_CSE1L_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2ATG12_DRAM_FAS_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1ATG12_DIABLO_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_MMP9_AGER_HMGB2ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2ATG12_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2 ATG12_DRAM_FAS_CDH1_ID2_AGER_BECN1_HMGB2ATG12_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_CDH1_TCF3_BECN1_HMGB2_SESN3_SIRT1ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2 ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2_MMP2ATG12_ATG3_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_LC3_CDH1_ID2_MMP9_AGER_BECN1_HMGB2ATG12_CDH1_ID2_AGER_BECN1_HMGB2_SIRT1 AIFM1_CASP8_LAMP1_CDH1_AGER_CIAP2_HMGB2_RPS19BP1ATG12_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1 ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1AIFM1_ATG3_CASP8_CSE1L_LC3_CDH1_MMP9 ATG12_ATG3_DIABLO_CDH1_BECN1_HMGB2_SESN3_SIRT1ATG12_ATG3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_HMGB2_SESN3ATG12_LC3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_FAS_CDH1_TCF3_CIAP2_HMGB2_SESN3AIFM1_CASP8_LC3_CDH1_AGER_HMGB2_RPS19BP1 ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2_RPS19BP1ATG12_ATG5_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_CDH1_ID2_TCF3_AGER_BECN1_HMGB2ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_BNIP3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1AIFM1_ATG3_ATG5_CASP8_LC3_CDH1_MMP9 ATG12_DRAM_LC3_CDH1_ID2_MMP9_AGER_HMGB2ATG12_ATG5_DRAM_CDH1_ID2_BECN1_HMGB2 ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_RPS19BP1_SESN3ATG12_BNIP3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2_RPS19BP1ATG12_BNIP3_CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_LAMP1_CDH1_ID2_TCF3_AGER_BECN1_HMGB2ATG12_CDH1_ID2_MMP9_TCF3_AGER_HMGB2 ATG12_CDH1_ID2_MMP9_TCF3_AGER_BECN1_HMGB2。
7.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测A1组的无病存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表6]
一种两种的组合三种的组合四种的组合
MMP2 ID2_CDH2 FRAP1_CASP3_CDH2 FRAP1_TKT_CASP3_CDH2
ID2 FRAP1_TWIST1 ID2_CDH2_SESN3 ID2_CDH2_MMP2_SESN3
TWIST1 FRAP1_CASP3 ID2_CDH2_MMP2 CBS_ID2_CDH2_SESN3
BECN1 FRAP1_SESN1 FRAP1_CDH2_TWIST1 FRAP1_TKT_CDH2_TWIST1
BAX BAX_FRAP1 FRAP1_CDH2_SESN1 FRAP1_LC3_CASP3_CDH2
BCL2L1 FRAP1_NNMT FRAP1_NNMT_CDH2 FRAP1_NNMT_TKT_CDH2
CDH2 FRAP1_CCNG2 AIFM1_FRAP1_CDH2 ID2_CDH2_RPS19BP1_SESN3
FASLG BCL2L1_FRAP1 FRAP1_TKT_TWIST1 BAX_FRAP1_TKT_CDH2
AGER FRAP1_RAGE BAX_FRAP1_CDH2 BAX_FRAP1_LC3_CDH2
ATG12 AIFM1_FRAP1 FRAP1_LC3_TWIST1 ATG12_ID2_CDH2_SESN3
TKT BCL2_FRAP1 AKT1_ID2_CDH2 ATG12_ID2_MMP2_SESN3
FRAP1_VEGF ATG12_ID2_MMP2 FRAP1_LC3_CDH2_KIAA1967
FRAP1_PTEN FRAP1_CDH2_KIAA1967 AIFM1_FRAP1_TKT_CDH2
HMGB1_TWIST1 FRAP1_CCNG2_CDH2 FRAP1_TKT_CDH2_SESN1
ATG12_ID2 FRAP1_NNMT_MMP2 ID2_MMP2_RPS19BP1_SESN3
FRAP1_RAPTOR FRAP1_CDH2_RAGE FRAP1_CDH2_SESN1_STAT3
FRAP1_KIAA1967 BCL2L1_FRAP1_CDH2 FRAP1_LC3_CDH2_TWIST1
ID2_BECN1 FRAP1_TKT_CASP3 FRAP1_LC3_NNMT_CDH2
BECN1_SESN3 ATG12_MMP2_SESN3 FRAP1_LC3_CDH2_RAPTOR
ATG12_MMP2 FRAP1_CDH2_VEGF FRAP1_TKT_CCNG2_CDH2
CDH2_SESN3 ID2_CDH2_HMGB1 DIABLO_ID2_CDH2_SESN3
ID2_MMP2 FRAP1_PTEN_CDH2 ID2_CDH2_HMGB2_SESN3
FRAP1_XIAP CDH1_ID2_CDH2 FRAP1_TKT_CDH2_KIAA1967
AKT1_CDH2 FRAP1_CASP3_MMP2 FRAP1_LC3_CDH2_RAGE
FRAP1_PRKAA1 FRAP1_LC3_CASP3 BAX_FRAP1_TKT_MMP2
ID2_RPS19BP1 BCL2_FRAP1_CDH2 BCL2L1_FRAP1_TKT_CDH2
TKT_MMP2 BAX_FRAP1_TKT FRAP1_CASP3_CDH2_STAT3
BAX_TWIST1 FRAP1_CDH2_RAPTOR FRAP1_PTEN_TKT_CDH2
BECN1_FASLG BAX_FRAP1_LC3 FRAP1_ID2_CDH2_TWIST1
ATG12_SESN3 BAX_FRAP1_MMP2 ID2_CDH2_NAMPT_SESN3
CDH2_MMP2 FAS_ID2_CDH2 FRAP1_TKT_CDH2_VEGF
BECN1_MMP2 FRAP1_RPS19BP1_TWIST1 FRAP1_LC3_CDH2_VEGF
BAX_MMP2 FRAP1_LC3_NNMT FRAP1_NNMT_CDH2_MMP2
ID2_NAMPT FRAP1_LC3_RAGE AIFM1_FRAP1_LC3_CDH2
CASP8_ID2 FRAP1_HMGB1_TWIST1 FRAP1_LC3_PTEN_CDH2
ID2_TWIST1 FRAP1_SESN1_STAT3 FRAP1_TKT_CDH2_RAGE
MMP2_SESN3 FRAP1_TKT_SESN1 FRAP1_CDH2_HMGB1_TWIST1
AKT1_BAX ATG3_ID2_CDH2 FAS_FRAP1_CDH2_SESN1
FRAP1_TP63 FRAP1_ID2_CDH2 FRAP1_CASP3_CDH2_MMP2
BAX_LC3 FRAP1_TKT_CCNG2 DRAM_ID2_CDH2_SESN3
ATG12_FASLG FAS_FRAP1_TWIST1 LC3_HMGB1_STAT3_TWIST1
LC3_TWIST1 FRAP1_NNMT_TKT CASP8_ID2_CDH2_SESN3
AKT1_TWIST1 AIFM1_FRAP1_MMP2 FRAP1_TKT_CDH2_RAPTOR
ID2_FASLG ID2_CDH2_CIAP2 BCL2L1_FRAP1_LC3_CDH2
STAT3_TWIST1 FRAP1_LC3_VEGF FRAP1_CDH2_KIAA1967_MMP2
TKT_FASLG CDH2_MMP2_SESN3 FRAP1_TKT_CASP3_FASLG
AKT1_ATG12 ID2_CDH2_FASLG TKT_ID2_CDH2_MMP2
MMP2_NAMPT CBS_ID2_CDH2 FRAP1_NNMT_TKT_MMP2
ID2_SIRT1 FRAP1_LC3_CCNG2 FRAP1_TKT_CASP3_MMP2
ID2_AGER BCL2L1_FRAP1_TKT ID2_CDH2_CIAP2_SESN3
ATG7_TWIST1 FRAP1_ID2_TWIST1 FRAP1_CDH2_STAT3_TWIST1
AKT1_BCL2L1 AIFM1_FRAP1_LC3 CBS_FRAP1_CASP3_CDH2
BAX_TKT AIFM1_FRAP1_TKT BAX_FRAP1_CDH2_MMP2
KIAA1967_MMP2 ATG5_ID2_CDH2 ATG12_TKT_MMP2_SESN3
BCL2L1_MMP2 FRAP1_TKT_RAGE FRAP1_CDH1_CASP3_CDH2
ATG7_TP63 BCL2L1_FRAP1_MMP2 BAX_FRAP1_BECN1_CDH2
LC3_BECN1 FRAP1_CDH2_TP63 ID2_CDH2_HMGB1_MMP2
CDH1_ID2_MMP9_TCF3
五种的组合六种的组合
ID2_CDH2_MMP2_RPS19BP1_SESN3 AKT1_ATG12_FAS_CDH2_STAT3_TP63
ATG12_ID2_CDH2_MMP2_SESN3 AKT1_FAS_BECN1_CDH2_STAT3_TP63
FRAP1_LC3_CASP3_CDH2_STAT3 AKT1_FAS_CDH2_RPS19BP1_STAT3_TP63
ATG12_ID2_MMP2_RPS19BP1_SESN3 AKT1_FAS_LC3_CDH2_STAT3_TP63
AKT1_FAS_CDH2_STAT3_TP63 ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CASP3_CDH2_STAT3 AKT1_ATG12_BECN1_CDH2_STAT3_TP63
CASP8_ID2_CDH2_MMP2_SESN3 AKT1_ATG7_FAS_CDH2_RPS19BP1_TP63
FRAP1_TKT_CASP3_CDH2_FASLG ATG12_ID2_CDH2_HMGB1_MMP2_SESN3
BAX_FRAP1_LC3_TKT_CDH2 FRAP1_LC3_BECN1_CASP3_CDH2_STAT3
ID2_CDH2_HMGB2_MMP2_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_STAT3
DIABLO_ID2_CDH2_MMP2_SESN3 FRAP1_LC3_NNMT_BECN1_CDH2_STAT3
FRAP1_LAMP1_TKT_CASP3_CDH2 ID2_CDH2_HMGB2_MMP2_RPS19BP1_SESN3
CBS_ID2_CDH2_MMP2_SESN3 ATG12_ID2_CDH2_CIAP2_MMP2_SESN3
FRAP1_LC3_NNMT_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_SESN1_STAT3
FRAP1_TKT_CDH2_SESN1_STAT3 FRAP1_TKT_BECN1_CASP3_CDH2_STAT3
LC3_CDH2_HMGB1_STAT3_TWIST1 ATG12_FRAP1_ID2_CDH2_MMP2_SESN3
DRAM_ID2_CDH2_MMP2_SESN3 FAS_LC3_CDH2_HMGB1_STAT3_TWIST1
FRAP1_LC3_CDH2_SESN1_STAT3 ATG12_TKT_ID2_CDH2_MMP2_SESN3
CBS_FRAP1_TKT_CASP3_CDH2 ID2_CDH2_CIAP2_MMP2_RPS19BP1_SESN3
ID2_MMP2_NAMPT_RPS19BP1_SESN3 AKT1_CASP8_FAS_CDH2_STAT3_TP63
AKT1_ID2_CDH2_RPS19BP1_SESN3 AKT1_FAS_CASP3_CDH2_STAT3_TP63
ID2_CDH2_MMP2_NAMPT_SESN3 FAS_FRAP1_LC3_NNMT_CDH2_STAT3
AKT1_BECN1_CDH2_STAT3_TP63 FAS_FRAP1_TKT_CDH2_SESN1_STAT3
FAS_FRAP1_LC3_CDH2_RAPTOR ATG12_ID2_CDH2_MMP2_SESN3_STAT3
FRAP1_LC3_CDH2_STAT3_TWIST1 FRAP1_NNMT_TKT_BECN1_CDH2_STAT3
BAX_FRAP1_TKT_CDH2_MMP2 ATG12_FAS_FRAP1_CDH2_STAT3_TP63
FAS_FRAP1_LC3_CDH2_KIAA1967 ATG12_ATG3_ID2_CDH2_MMP2_SESN3
AKT1_ATG7_CDH2_RPS19BP1_TP63 DRAM_ID2_CDH2_MMP2_RPS19BP1_SESN3
FAS_FRAP1_LC3_CDH2_RAGE ATG12_CBS_ID2_CDH2_MMP2_SESN3
FAS_LC3_HMGB1_STAT3_TWIST1 ID2_CDH2_MMP2_RPS19BP1_SESN3_STAT3
FRAP1_LC3_TKT_CASP3_CDH2 FRAP1_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CASP3_CDH2_CIAP2 AKT1_ID2_CDH2_MMP2_RPS19BP1_SESN3
TKT_ID2_CDH2_MMP2_SESN3 FAS_FRAP1_LC3_CASP3_CDH2_STAT3
FRAP1_TKT_CDH2_KIAA1967_MMP2 ATG5_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CDH2_HMGB1_TWIST1 AKT1_FAS_CDH2_HMGB1_STAT3_TP63
BAX_FRAP1_LC3_BECN1_CDH2 CSE1L_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CDH2_STAT3_TWIST1 ATG3_ID2_CDH2_MMP2_RPS19BP1_SESN3
AKT1_ATG12_ID2_CDH2_SESN3 FRAP1_LC3_NNMT_TKT_CDH2_STAT3
BAX_FAS_FRAP1_LC3_CDH2 CBS_ID2_CDH2_MMP2_RPS19BP1_SESN3
ATG12_CBS_ID2_MMP2_SESN3 AKT1_ATG12_CDH2_HMGB1_STAT3_TP63
FAS_FRAP1_CDH2_SESN1_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR_RPS19BP1
FRAP1_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_ID2_CDH2_MMP2_SESN3
FAS_FRAP1_TKT_CDH2_SESN1 ATG12_ATG5_ID2_CDH2_MMP2_SESN3
FRAP1_LC3_CCNG2_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_STAT3_TP63
ID2_CDH2_MMP2_SESN3_UVRAG AKT1_FAS_BECN1_RPS19BP1_STAT3_TP63
ATG7_ID2_CDH2_MMP2_SESN3 FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR
ID2_CDH2_HMGB1_RPS19BP1_SESN3 FAS_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CDH2_MMP2_RAPTOR ATG12_CDH1_ID2_CDH2_MMP2_SESN3
FRAP1_LC3_BECN1_CDH2_RAPTOR FRAP1_LC3_TKT_CDH2_STAT3_TWIST1
ATG12_ID2_CDH2_FASLG_SESN3 CDH1_ID2_CDH2_MMP2_RPS19BP1_SESN3
ATG7_FRAP1_TKT_CASP3_CDH2 FAS_FRAP1_LC3_CDH2_KIAA1967_RPS19BP1
FRAP1_TKT_CASP3_CDH2_MMP2 FRAP1_LC3_CDH2_HMGB1_STAT3_TWIST1
FRAP1_LC3_CDH2_HMGB1_TWIST1 ATG12_ID2_CDH2_HMGB2_MMP2_SESN3
FRAP1_LC3_TKT_CDH2_KIAA1967 ATG12_FAS_ID2_CDH2_MMP2_SESN3
ATG7_ID2_CDH2_RPS19BP1_TP63 TKT_ID2_CDH2_MMP2_RPS19BP1_SESN3
BAX_FRAP1_TKT_BECN1_CDH2 BAX_FAS_FRAP1_LC3_TKT_CDH2
ATG3_FRAP1_TKT_CASP3_CDH2 ATG12_ID2_CDH2_MMP2_RPS19BP1_SESN3
CDH1_ID2_MMP9_TCF3_CDH2 CDH1_ID2_MMP9_TCF3_CDH2_SESN3
七种的组合八种的组合
AKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63AKT1_ATG12_FAS_CASP3_CDH2_STAT3_TP63 AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_LAMP1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_CDH2_HMGB2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63AIFM1_AKT1_ATG12_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_CDH2_CIAP2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_KIAA1967_STAT3_TP63AKT1_ATG12_FAS_CDH2_SESN2_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RAPTOR_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_NNMT_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_BCL2L1_FAS_BECN1_CDH2_STAT3_TP63AKT1_ATG12_FAS_CDH2_NAMPT_STAT3_TP63 AKT1_CASP8_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63AKT1_ATG12_FAS_CDH2_SIRT1_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_LC3_CDH2_STAT3_TP63AKT1_FAS_LC3_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_LC3_CDH2_STAT3_TP63AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RAPTOR_RPS19BP1_STAT3_TP63AKT1_ATG12_DRAM_FAS_CDH2_STAT3_TP63 AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_NNMT_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_BECN1_RPS19BP1_STAT3_TP63AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63AKT1_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_CDH2_HMGB1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63ATG12_FAS_FRAP1_LC3_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_LAMP1_CDH2_STAT3_TP63AKT1_ATG12_FAS_XIAP_CDH2_STAT3_TP63 AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63AKT1_ATG12_FAS_CDH2_LAMP2_STAT3_TP63 AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63AKT1_ATG12_ATG3_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63AKT1_ATG12_FAS_PTEN_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63AKT1_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH1_BECN1_CDH2_STAT3_TP63AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_TP63 AKT1_CASP8_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_LC3_CDH2_HMGB1_STAT3_TP63 AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_TKT_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_CIAP2_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 AKT1_FAS_CDH2_HMGB1_HMGB2_RPS19BP1_STAT3_TP63AKT1_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CASP3_CDH2_STAT3_TP63AKT1_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTOR AKT1_ATG12_E2F1_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_E2F1_FAS_CDH2_STAT3_TP63 AKT1_ATG12_DRAM_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63 AKT1_FAS_CASP3_CDH2_RPS19BP1_SESN2_STAT3_TP63AKT1_FAS_NNMT_BECN1_CDH2_STAT3_TP63 AKT1_FAS_CDH2_HMGB2_RPS19BP1_SESN2_STAT3_TP63AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CASP3_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_BECN1_CDH2_LAMP2_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 AKT1_FAS_TKT_CDH2_RPS19BP1_SESN2_STAT3_TP63FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 AKT1_ATG12_ATG3_FAS_CDH2_RPS19BP1_STAT3_TP63ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3 AKT1_ATG12_FAS_XIAP_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_CDH2_RAPTOR_STAT3_TP63 AKT1_ATG12_CASP8_FAS_NNMT_CDH2_STAT3_TP63FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_CASP8_FAS_CASP3_CDH2_STAT3_TP63FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1 AKT1_ATG12_FAS_CDH2_RPS19BP1_SIRT1_STAT3_TP63FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 AKT1_ATG12_BCL2L1_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_TKT_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_HMGB2_STAT3_TP63AKT1_CASP8_FAS_LC3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_NNMT_CDH2_STAT3_TP63AKT1_FAS_LC3_CASP3_CDH2_STAT3_TP63 AIFM1_AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63AKT1_FAS_LAMP1_BECN1_CDH2_STAT3_TP63 AKT1_ATG7_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_TP63 AKT1_ATG12_FAS_PTEN_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_TCF3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_CIAP2_STAT3_TP63CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3 AKT1_CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3。
8.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测A2组的复发预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表7]
一种两种的组合三种的组合四种的组合
TKT PRKAA1_LAMP2 LC3_SESN2_SIRT1 ATG5_LC3_SESN2_SIRT1
SESN2 TKT_SESN2 BNIP3_PRKAA1_LAMP2 ATG3_LC3_SESN2_SIRT1
LAMP2 ATG7_LAMP2 ATG5_LC3_SESN2 CSE1L_LC3_SESN2_SIRT1
LAMP2_SESN2 BNIP3_LC3_SESN2 ATG5_CSE1L_LC3_SESN2
AKT1_PRKAA1 ATG7_LC3_SESN2 BNIP3_LC3_SESN2_SIRT1
SESN2_SIRT1 AKT1_PRKAA1_LAMP2 FRAP1_LC3_SESN2_SIRT1
TKT_VEGF ATG7_TKT_SESN2 AKT1_ATG3_PRKAA1_LAMP2
ATG7_TKT DRAM_LC3_SESN2 ATG3_ATG5_LC3_SESN2
TKT_LAMP2 PRKAA1_AGER_LAMP2 ATG7_LC3_SESN2_SIRT1
BHLHE41_SESN2 PRKAA1_TKT_LAMP2 BNIP3_CSE1L_LC3_SESN2
TKT_BHLHE41 ATG7_TKT_LAMP2 TKT_LAMP2_SESN2_SIRT1
ATG5_SESN2 TKT_LAMP2_SESN2 CIAP2_LAMP2_SESN2_SIRT1
LAMP1_SESN2 TKT_LAMP2_VEGF ATG12_TKT_LAMP2_SESN2
CSE1L_LAMP2 ATG12_LC3_SESN2 ATG7_TKT_LAMP2_SESN2
ATG12_SESN2 ATG7_LAMP2_SESN2 AKT1_ATG7_PRKAA1_LAMP2
AKT1_TKT TKT_SESN2_SIRT1 ATG5_BNIP3_LC3_SESN2
E2F1_SESN2 E2F1_LC3_SESN2 ATG3_BNIP3_LC3_SESN2
ATG3_LAMP2 LC3_SESN2_UVRAG AKT1_PRKAA1_LAMP2_UVRAG
BNIP3_SESN2 PRKAA1_CCNG2_LAMP2 DRAM_LC3_SESN2_SIRT1
LC3_SESN2 AKT1_ATG7_TKT ATG7_CSE1L_LC3_SESN2
TWIST1_VEGF ATG5_PRKAA1_LAMP2 ATG7_FRAP1_LC3_SESN2
ATG7_LC3 ATG3_LAMP2_SESN2 BNIP3_PRKAA1_LAMP2_SESN2
CSE1L_SESN2 BNIP3_TKT_SESN2 ATG5_ATG7_LC3_SESN2
ATG5_LC3 LAMP2_SESN2_SIRT1 PRKAA1_TKT_LAMP2_SESN2
ATG7_SESN2 ATG7_PRKAA1_LAMP2 ATG3_ATG7_LC3_SESN2
LC3_ULK1 LAMP1_LC3_SESN2 BNIP3_PRKAA1_AGER_LAMP2
ATG3_TKT ATG12_PRKAA1_LAMP2 E2F1_LC3_SESN2_SIRT1
DRAM_SESN2 CASP8_PRKAA1_LAMP2 LC3_ID2_SESN2_SIRT1
PRKAA1_TKT AIFM1_TKT_SESN2 LC3_NAMPT_SESN2_SIRT1
BHLHE41_LAMP2 FRAP1_SESN2_SIRT1 ATG5_FRAP1_LC3_SESN2
LAMP2_VEGF PRKAA1_HMGB1_LAMP2 ATG7_BNIP3_LC3_SESN2
AKT1_VEGF LC3_BHLHE41_SESN2 LC3_RPS19BP1_SESN2_SIRT1
TKT_CIAP2 ATG12_TKT_SESN2 AKT1_ATG7_TKT_SESN2
CSE1L_BHLHE41 CSE1L_LAMP2_SESN2 BCL2L1_BNIP3_PRKAA1_LAMP2
LC3_BHLHE41 PRKAA1_CASP3_LAMP2 CSE1L_DRAM_LC3_SESN2
LC3_SIRT1 PRKAA1_LAMP2_RAGE DIABLO_LC3_SESN2_SIRT1
CSE1L_LAMP1 PRKAA1_LAMP2_SESN2 LC3_SESN2_SIRT1_STAT3
TKT_RPS19BP1 TKT_CIAP2_SESN2 ATG12_ATG5_LC3_SESN2
CBS_TKT BCL2L1_PRKAA1_LAMP2 BNIP3_PRKAA1_TCF3_LAMP2
CSE1L_BECN1 DIABLO_PRKAA1_LAMP2 LC3_SESN2_SIRT1_UVRAG
TKT_CDH1 PRKAA1_CDH1_LAMP2 BNIP3_PRKAA1_MMP9_LAMP2
TKT_HMGB1 CBS_PRKAA1_LAMP2 AKT1_LC3_SESN2_SIRT1
TKT_RAGE CSE1L_SESN2_SIRT1 AKT1_PRKAA1_CDH1_LAMP2
AIFM1_SESN2 ATG3_PRKAA1_LAMP2 CSE1L_LAMP1_LC3_SESN2
ATG7_TWIST1 PRKAA1_FASLG_LAMP2 ATG7_PRKAA1_TKT_LAMP2
BHLHE41_NAMPT PRKAA1_ID2_LAMP2 KIAA1967_LAMP2_SESN2_SIRT1
BNIP3_LC3 PRKAA1_LAMP2_SATB1 LC3_SESN2_SESN3_SIRT1
PRKAA1_SESN2 PRKAA1_LAMP2_SESN1 BNIP3_PRKAA1_HMGB1_LAMP2
ATG7_NAMPT AKT1_ATG7_PTEN CSE1L_LC3_SESN2_UVRAG
BECN1_SESN2 ATG7_TKT_BHLHE41 LC3_MMP9_SESN2_SIRT1
TKT_HMGB2 PRKAA1_LAMP2_MMP2 ATG3_LAMP2_SESN2_SIRT1
TKT_SIRT1 CSE1L_LAMP1_SESN2 BNIP3_PRKAA1_CCNG2_LAMP2
ATG5_CSE1L PRKAA1_LAMP2_SESN3 BNIP3_PRKAA1_LAMP2_SATB1
SESN2_UVRAG ATG3_TKT_SESN2 BNIP3_PRKAA1_LAMP2_SESN1
TKT_CASP3 ATG5_CSE1L_SESN2 ATG5_DRAM_LC3_SESN2
TKT_CDH2 ATG5_CSE1L_LC3 BNIP3_PRKAA1_CASP3_LAMP2
TKT_MMP2 FRAP1_PRKAA1_LAMP2 BNIP3_FRAP1_LC3_SESN2

五种的组合六种的组合
CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG5_LC3_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_FRAP1_LC3_SESN2_SIRT1 NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG7_FRAP1_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
TKT_CIAP2_LAMP2_SESN2_SIRT1 AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_FRAP1_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SESN1_SESN2_SIRT1
ATG5_BNIP3_LC3_SESN2_SIRT1 CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1
TKT_CDH1_LAMP2_SESN2_SIRT1 CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
CSE1L_FRAP1_LC3_SESN2_SIRT1 AKT1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_BNIP3_LC3_SESN2_SIRT1 ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_CSE1L_LC3_SESN2_SIRT1 FAS_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_LC3_LAMP2_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1
BNIP3_FRAP1_LC3_SESN2_SIRT1 TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
BNIP3_PRKAA1_TKT_LAMP2_SESN2 ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1
ATG12_TKT_LAMP2_SESN2_SIRT1 ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_ATG7_LC3_SESN2_SIRT1 BCL2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG7_BNIP3_TKT_LAMP2_SESN2 CIAP2_FASLG_LAMP2_RAGE_SESN2_SIRT1
AKT1_ATG7_BNIP3_PRKAA1_LAMP2 ATG5_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG7_LC3_SESN2_SIRT1 CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG5_BNIP3_LC3_SESN2 FRAP1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
BNIP3_CSE1L_LC3_SESN2_SIRT1 MMP9_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_DRAM_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1
AIFM1_CIAP2_LAMP2_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC3_SESN2_SIRT1
ATG7_TKT_LAMP2_SESN2_SIRT1 CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_CSE1L_FRAP1_LC3_SESN2 LAMP1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG7_LC3_NAMPT_SESN2_SIRT1 TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_E2F1_LC3_SESN2_SIRT1 ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1
BNIP3_CSE1L_FRAP1_LC3_SESN2 ATG3_ATG7_LC3_LAMP2_SESN2_SIRT1
ATG7_LC3_LAMP2_SESN2_SIRT1 ATG3_BNIP3_FRAP1_LC3_SESN2_SIRT1
AIFM1_BNIP3_PRKAA1_LAMP2_SESN2 ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1
ATG12_BNIP3_TKT_LAMP2_SESN2 ATG3_ATG5_BNIP3_LC3_SESN2_SIRT1
CIAP2_KIAA1967_LAMP2_SESN2_SIRT1 E2F1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG12_ATG5_BNIP3_LC3_SESN2 ATG3_BNIP3_LC3_LAMP2_SESN2_SIRT1
ATG3_ATG7_LC3_LAMP2_SESN2 ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1
ATG12_TKT_CIAP2_LAMP2_SESN2 ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1
ATG5_BNIP3_CSE1L_LC3_SESN2 TKT_CDH1_CIAP2_LAMP2_SESN2_SIRT1
AKT1_ATG7_PRKAA1_TKT_LAMP2 ATG5_BNIP3_E2F1_LC3_SESN2_SIRT1
ATG3_LC3_NAMPT_SESN2_SIRT1 ATG3_ATG7_LC3_NAMPT_SESN2_SIRT1
ATG3_CSE1L_LC3_SESN2_SIRT1 AIFM1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG7_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG5_LC3_ID2_SESN2_SIRT1 CBS_TKT_CIAP2_LAMP2_SESN2_SIRT1
BNIP3_E2F1_LC3_SESN2_SIRT1 ATG3_ATG5_LC3_ID2_SESN2_SIRT1
ATG3_LC3_ID2_SESN2_SIRT1 AIFM1_TKT_CIAP2_LAMP2_SESN2_SIRT1
ATG7_CSE1L_FRAP1_LC3_SESN2 ATG3_DRAM_FRAP1_LC3_SESN2_SIRT1
AIFM1_TKT_LAMP2_SESN2_SIRT1 ATG3_ATG5_E2F1_LC3_SESN2_SIRT1
LC3_CIAP2_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_LAMP2_SESN2_SIRT1
ATG12_TKT_CDH1_LAMP2_SESN2 ATG3_ATG5_LC3_SESN2_SIRT1_STAT3
ATG5_LC3_SESN2_SIRT1_STAT3 AIFM1_AKT1_LAMP2_SESN2_SIRT1_UVRAG
ATG3_DRAM_LC3_SESN2_SIRT1 AKT1_ATG7_TKT_LAMP2_SESN2_SIRT1
ATG5_DIABLO_LC3_SESN2_SIRT1 ATG3_ATG5_LC3_NAMPT_SESN2_SIRT1
ATG7_BNIP3_LC3_SESN2_SIRT1 ATG3_ATG5_DIABLO_LC3_SESN2_SIRT1
CDH2_CIAP2_LAMP2_SESN2_SIRT1 TKT_CDH1_HMGB1_LAMP2_SESN2_SIRT1
ATG3_ATG5_FRAP1_LC3_SESN2 ATG3_ATG5_LC3_LAMP2_SESN2_SIRT1
DRAM_TKT_LAMP2_SESN2_SIRT1 ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1
ATG12_ATG3_TKT_LAMP2_SESN2 BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG3_LC3_SESN2_SIRT1_STAT3 AKT1_ATG3_ATG5_LC3_SESN2_SIRT1
ATG5_LC3_SESN2_SIRT1_UVRAG AIFM1_BNIP3_PRKAA1_TKT_LAMP2_SESN2
TKT_CDH1_ID2_MMP9_TCF3_SESN2
七种的组合八种的组合
ATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_ID2_FASLG_LAMP2_SESN2_SIRT1MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 ATG5_FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN2_SIRT1LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1FAS_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1CIAP2_FASLG_LAMP2_NAMPT_SESN1_SESN2_SIRT1 ATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1_STAT3CIAP2_FASLG_LAMP2_MMP2_SESN1_SESN2_SIRT1 NNMT_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 FRAP1_AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1LC3_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN1_SESN2_SIRT1ATG5_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 TCF3_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 TCF3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SATB1_SESN2_SIRT1AKT1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FAS_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 NNMT_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1 ATG3_ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1NNMT_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 AKT1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 FRAP1_LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1AGER_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 FRAP1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1BCL2_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_ID2_FASLG_LAMP2_SESN2_SIRT1BCL2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1_STAT3ULK1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 C IAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN1_SESN2_SIRT1LC3_CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1LC3_CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_BECN1_FASLG_LAMP2_SESN2_SIRT1AKT1_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC3_FASLG_LAMP2_SESN2_SIRT1FRAP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 NNMT_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1FRAP1_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SESN3_SIRT1CASP3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1CIAP2_FASLG_HMGB1_LAMP2_SESN1_SESN2_SIRT1 FAS_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN1_SESN2_SIRT1ATG5_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SATB1_SESN2_SIRT1ID2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BCL2_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1TCF3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ULK1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1FAS_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN2_SIRT1LAMP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BCL2_FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1 AKT1_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1TCF3_CIAP2_FASLG_LAMP2_SESN1_SESN2_SIRT1 ATG7_BNIP3_LC3_MMP9_FASLG_LAMP2_SESN2_SIRT1FRAP1_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 MMP9_AGER_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG3_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 FRAP1_LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1AKT1_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1NNMT_ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CASP3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CDH2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1MMP9_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1BNIP3_PRKAA1_CDH1_ID2_MMP9_TCF3_LAMP2 TKT_CDH1_ID2_MMP9_TCF3_LAMP2_SESN2_SIRT1。
9.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测A2组的存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表8]
一种两种的组合三种的组合四种的组合
BCL2L1 BCL2L1_NNMT BCL2L1_NNMT_PRKAA1 ATG3_BCL2L1_NNMT_PRKAA1
FAS BCL2L1_E2F1 BCL2L1_E2F1_PRKAA1 BCL2L1_TKT_CASP3_SESN2
LAMP1 BCL2L1_TKT ATG3_BCL2L1_PRKAA1 BCL2L1_ID2_CASP3_SESN2
BHLHE41 FAS_LAMP1 ATG3_BCL2L1_NNMT ATG3__BCL2L1__E2F1_PRKAA1
TKT BCL2L1_PRKAA1 ATG3_BCL2L1_E2F1 BCL2L1_NNMT_PRKAA1_HMGB1
LC3 FAS_BHLHE41 FAS_BHLHE41_SESN2 BCL2L1_NNMT_PRKAA1_MMP2
SESN2 FAS_TKT BCL2L1_PRKAA1_HMGB2 BCL2L1_NNMT_PRKAA1_CDH1
BCL2L1_CASP3 BCL2L1_CASP3_SESN2 FAS_TKT_CASP3_SESN2
ATG3_BCL2L1 BCL2L1_PRKAA1_TKT BCL2L1_NNMT_PRKAA1_VEGF
ATG7_BCL2L1 FAS_CASP3_SESN2 ATG7_BCL2L1_NNMT_PRKAA1
FAS_CASP3 BCL2L1_TKT_CASP3 BCL2L1_FRAP1_NNMT_PRKAA1
TKT_BHLHE41 FAS_TKT_CASP3 BCL2L1_NNMT_PRKAA1_ID2
BCL2L1_KIAA1967 BCL2L1_E2F1_TKT AIFM1_BCL2L1_NNMT_PRKAA1
FAS_PRKAA1 BCL2L1_NNMT_TKT BCL2L1_TKT_BHLHE41_CASP3
FAS_KIAA1967 FAS_TKT_BHLHE41 BCL2L1_NNMT_PRKAA1_CDH2
FAS_SESN2 FAS_TKT_SESN2 BCL2L1_CSE1L_NNMT_PRKAA1
BCL2L1_HMGB2 FAS_LAMP1_BHLHE41 BCL2L1_NNMT_PRKAA1_HMGB2
BCL2L1_VEGF FAS_LAMP1_SESN2 BCL2L1_CBS_NNMT_PRKAA1
BNIP3_FAS ATG3_BCL2L1_TKT FAS_TKT_SESN2_TP63
FAS_TWIST1 ATG7_BCL2L1_PRKAA1 BCL2L1_DRAM_NNMT_PRKAA1
BNIP3_TKT DIABLO_FAS_BHLHE41 BCL2L1_NNMT_PRKAA1_ULK1
BCL2L1_CSE1L TKT_SESN2_TP63 BNIP3_TKT_CASP3_SESN2
TKT_SESN2 FAS_PRKAA1_TKT ATG5_BCL2L1_NNMT_PRKAA1
BCL2L1_FRAP1 ATG7_BCL2L1_NNMT BCL2L1_DIABLO_NNMT_PRKAA1
LAMP1_SESN2 BCL2L1_BNIP3_TKT BCL2L1_NNMT_CASP3_SESN2
LC3_BHLHE41 BNIP3_FAS_TKT FAS_TKT_BHLHE41_CASP3
BCL2L1_BNIP3 BCL2L1_NNMT_CASP3 BCL2L1_NNMT_PRKAA1_TKT
BCL2L1_LC3 TKT_BHLHE41_CASP3 BNIP3_FAS_TKT_CASP3
ATG5_BCL2L1 ATG3_BCL2L1_CASP3 ATG3_ATG7_BCL2L1_PRKAA1
BCL2L1_CBS BCL2L1_PRKAA1_CASP3 FAS_ID2_CASP3_SESN2
CSE1L_LAMP1 BCL2L1_PRKAA1_MMP2 BCL2L1_NNMT_PRKAA1_CASP3
E2F1_FAS FAS_BHLHE41_CASP3 ATG3_BCL2L1_PRKAA1_HMGB2
AIFM1_BCL2L1 FAS_TKT_KIAA1967 FAS_LC3_BHLHE41_SESN2
BHLHE41_SESN2 FAS_TKT_TWIST1 ATG3_BCL2L1_BNIP3_NNMT
CASP8_FAS BCL2L1_E2F1_NNMT BCL2L1_CASP8_NNMT_PRKAA1
FAS_NAMPT BCL2L1_FRAP1_NNMT FAS_BHLHE41_CASP3_SESN2
FAS_TP63 BCL2L1_TKT_BHLHE41 BCL2L1_BNIP3_NNMT_TKT
LAMP1_BHLHE41 BCL2L1_TKT_SESN2 DIABLO_FAS_BHLHE41_SESN2
ATG12_FAS FAS_KIAA1967_SESN2 ATG3_BCL2L1_PRKAA1_TKT
BCL2L1_MMP2 DIABLO_FAS_LAMP1 BCL2L1_NNMT_PRKAA1_MMP9
BHLHE41_CASP3 ATG3_BCL2L1_KIAA1967 BNIP3_FAS_CASP3_SESN2
FAS_HMGB1 ATG7_BCL2L1_E2F1 FAS_LAMP1_BHLHE41_SESN2
FAS_VEGF FAS_BHLHE41_SATB1 BCL2L1_CASP3_SESN1_SESN2
LAMP1_TCF3 ATG3_ATG7_BCL2L1 BCL2L1_NNMT_PRKAA1_SIRT1
BCL2L1_ULK1 ATG7_BCL2L1_TKT DIABLO_FAS_LAMP1_BHLHE41
FAS_LC3 BCL2L1_BNIP3_NNMT FAS_TKT_CASP3_SIRT1
NNMT_BHLHE41 BCL2L1_PRKAA1_VEGF E2F1_FAS_BHLHE41_SESN2
BCL2L1_FAS BCL2L1_BHLHE41_CASP3 FAS_TKT_CASP3_FASLG
TKT_TP63 FAS_SESN2_TP63 FAS_TKT_HMGB1_SESN2
AKT1_BCL2L1 TKT_BHLHE41_TP63 FAS_CASP3_HMGB1_SESN2
ATG12_BCL2L1 AIFM1_BCL2L1_NNMT BAX_BCL2L1_NNMT_PRKAA1
FAS_HMGB2 BCL2L1_CSE1L_NNMT BCL2L1_E2F1_NNMT_PRKAA1
BCL2L1_ID2 BCL2L1_E2F1_FRAP1 ATG3_BCL2L1_PRKAA1_MMP2
BCL2L1_RPS19BP1 BNIP3_FAS_CASP3 FAS_TKT_KIAA1967_SESN2
TKT_SATB1 FAS_TKT_SATB1 BNIP3_FAS_TKT_TWIST1
FAS_XIAP BCL2L1_CSE1L_PRKAA1 ATG3_BCL2L1_BNIP3_TKT
BCL2_BCL2L1 BCL2L1_NNMT_VEGF BCL2L1_NNMT_PRKAA1_PTEN

五种的组合六种的组合
BCL2L1_NNMT_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2
BCL2L1_PTEN_TKT_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_HMGB1 ATG3_BCL2L1_NNMT_PRKAA1_CASP3_SIRT1
BCL2L1_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_SESN1_SESN2
BCL2L1_TKT_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_ID2 BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2
BCL2L1_BNIP3_TKT_CASP3_SESN2 FAS_TKT_CASP3_HMGB1_SESN2_TP63
ATG3_BCL2L1_NNMT_PRKAA1_CDH1 ATG3_BCL2L1_NNMT_PRKAA1_KIAA1967_SIRT1
BCL2L1_TKT_CASP3_RAGE_SESN2 ATG3_BCL2L1_NNMT_ID2_CASP3_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_ULK1 ATG3_BCL2L1_NNMT_PRKAA1_HMGB1_VEGF
FAS_TKT_CASP3_HMGB1_SESN2 BCL2L1_PTEN_TKT_CASP3_SESN1_SESN2
FAS_TKT_CASP3_SESN2_TP63 BCL2L1_NNMT_ID2_AGER_CASP3_SESN2
ATG3_BCL2L1_FRAP1_NNMT_PRKAA1 BCL2L1_NNMT_ID2_BECN1_CASP3_SESN2
FAS_TKT_HMGB1_SESN2_TP63 BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN2
AIFM1_ATG3_BCL2L1_NNMT_PRKAA1 BCL2L1_PTEN_TKT_XIAP_CASP3_SESN2
BCL2L1_ID2_CASP3_SESN1_SESN2 ATG12_BCL2L1_NNMT_ID2_CASP3_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_MMP2 BNIP3_TKT_XIAP_CASP3_RAGE_SESN2
BCL2L1_TKT_CASP3_SESN1_SESN2 BCL2L1_NNMT_ID2_CASP3_CCNG2_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_VEGF AIFM1_BCL2L1_NNMT_ID2_CASP3_SESN2
BCL2L1_TKT_ID2_CASP3_SESN2 BCL2L1_PTEN_TKT_CASP3_RAGE_SESN2
ATG3_BCL2L1_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_CDH2_SESN2
BNIP3_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_LAMP2_SESN2
BCL2L1_NNMT_PRKAA1_ID2_SESN2 ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_FASLG
BCL2L1_NNMT_PRKAA1_HMGB1_VEGF BCL2L1_NNMT_ID2_CASP3_SESN2_SESN3
ATG3_BCL2L1_NNMT_PRKAA1_CDH2 BCL2L1_CSE1L_NNMT_ID2_CASP3_SESN2
ATG3_BCL2L1_LAMP1_NNMT_PRKAA1 BAX_BCL2L1_NNMT_ID2_CASP3_SESN2
BCL2L1_NNMT_ID2_SESN2_UVRAG BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2
ATG3_ATG7_BCL2L1_NNMT_PRKAA1 BCL2L1_NNMT_ID2_CASP3_MMP2_SESN2
ATG3_BCL2L1_CBS_NNMT_PRKAA1 BNIP3_PTEN_TKT_XIAP_CASP3_SESN2
BCL2L1_ID2_CASP3_RPS19BP1_SESN2 BCL2L1_BNIP3_TKT_ID2_CASP3_SESN2
BNIP3_FAS_TKT_CASP3_SESN2 BCL2L1_BNIP3_TKT_CASP3_SESN1_SESN2
ATG3_BCL2L1_DRAM_NNMT_PRKAA1 ATG3_ATG7_BCL2L1_NNMT_PRKAA1_HMGB1
ATG7_BCL2L1_NNMT_PRKAA1_HMGB1 BCL2L1_CASP8_NNMT_ID2_CASP3_SESN2
BCL2L1_NNMT_PRKAA1_HMGB1_HMGB2 ATG5_BCL2L1_NNMT_ID2_CASP3_SESN2
BCL2L1_FAS_TKT_CASP3_SESN2 BCL2L1_NNMT_CDH1_ID2_CASP3_SESN2
ATG3_BCL2L1_CSE1L_NNMT_PRKAA1 ATG3_BCL2L1_NNMT_PRKAA1_ID2_VEGF
ATG3_BCL2L1_DIABLO_NNMT_PRKAA1 BCL2L1_NNMT_PRKAA1_ID2_CASP3_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_SIRT1 BCL2L1_TKT_XIAP_CASP3_SESN1_SESN2
BCL2L1_CASP8_ID2_CASP3_SESN2 BCL2L1_NNMT_XIAP_ID2_CASP3_SESN2
BCL2L1_DIABLO_ID2_CASP3_SESN2 BCL2L1_DIABLO_NNMT_ID2_CASP3_SESN2
BCL2L1_TKT_CASP3_SESN2_STAT3 BCL2L1_TKT_XIAP_CASP3_HMGB1_SESN2
BCL2L1_NNMT_PRKAA1_ID2_VEGF BCL2L1_BNIP3_TKT_CASP3_RAGE_SESN2
BCL2L1_ID2_CASP3_HMGB2_SESN2 BCL2L1_TKT_BHLHE41_CASP3_SESN1_SESN2
BCL2L1_TKT_CASP3_SESN2_SESN3 BCL2L1_TKT_CASP3_HMGB1_RAGE_SESN2
BCL2L1_TKT_CASP3_CCNG2_SESN2 BCL2L1_PTEN_TKT_CASP3_CCNG2_SESN2
FAS_TKT_CASP3_FASLG_SESN2 BCL2L1_PRKAA1_TKT_XIAP_CASP3_SESN2
FAS_TKT_CASP3_SESN2_SIRT1 BCL2L1_TKT_CASP3_HMGB1_SESN1_SESN2
BCL2L1_NNMT_ID2_KIAA1967_SESN2 BNIP3_FAS_TKT_CASP3_HMGB1_SESN2
ATG5_BCL2L1_ID2_CASP3_SESN2 FAS_TKT_XIAP_CASP3_HMGB1_SESN2
BCL2L1_NNMT_PRKAA1_CASP3_SIRT1 BCL2L1_NNMT_ID2_SESN1_SESN2_UVRAG
BCL2L1_TKT_XIAP_BHLHE41_CASP3 FAS_TKT_HMGB1_KIAA1967_SESN2_TP63
FAS_TKT_XIAP_CASP3_SESN2 BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN2
BCL2L1_CDH1_ID2_CASP3_SESN2 BCL2L1_PTEN_TKT_ID2_CASP3_SESN2
BCL2L1_TKT_CASP3_SESN2_SIRT1 BCL2L1_ID2_CASP3_RAGE_RPS19BP1_SESN2
ATG7_BCL2L1_NNMT_PRKAA1_ID2 BNIP3_TKT_XIAP_CASP3_HMGB1_SESN2
BCL2_BCL2L1_TKT_CASP3_SESN2 ATG3_ATG7_BCL2L1_NNMT_PRKAA1_ID2
BCL2L1_ID2_CASP3_CDH2_SESN2 BCL2L1_BNIP3_NNMT_TKT_CASP3_SESN2
七种的组合八种的组合
BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_PTEN_XIAP_ID2_CASP3_SESN2BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_SESN3BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2ATG3_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2_SESN3BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN1_SESN2ATG3_BCL2L1_NNMT_PRKAA1_ID2_CASP3_SIRT1 BCL2_BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2BCL2L1_CASP8_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_RAGE_SESN2BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN2 BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN1_SESN2ATG3_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_HMGB1_SESN2BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_ID2_CASP3_SESN2BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_RAGE_SESN2BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2_SESN3 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2_SESN3BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN1_SESN2BNIP3_PTEN_TKT_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN1_SESN2ATG3_BCL2L1_NNMT_PRKAA1_XIAP_CASP3_SIRT1 BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_RPS19BP1_SESN2BCL2L1_BNIP3_NNMT_TKT_XIAP_CASP3_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2BCL2_BCL2L1_TKT_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG BCL2L1_NNMT_ID2_BHLHE41_CASP3_HMGB1_SESN1_SESN2ATG3_BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2 ATG3_BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2BCL2L1_NNMT_PRKAA1_ID2_CASP3_RAGE_SESN2 ATG5_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BCL2L1_PRKAA1_TKT_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_MMP2_SESN2BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2 BCL2L1_BNIP3_TKT_XIAP_CASP3_RAGE_RPS19BP1_SESN2BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2_SESN3ATG3_BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_MMP2_SESN2BCL2L1_BNIP3_NNMT_TKT_ID2_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CCNG2_SESN2BCL2L1_NNMT_ID2_CASP3_HMGB1_RAGE_SESN2 BCL2_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2BCL2L1_PRKAA1_TKT_XIAP_CASP3_RAGE_SESN2 ATG5_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2BCL2L1_PRKAA1_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_AGER_CASP3_SESN2BCL2L1_TKT_BHLHE41_CASP3_RAGE_SESN1_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN1_SESN2BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_LAMP2_SESN2BCL2L1_NNMT_ID2_BECN1_CASP3_RAGE_SESN2 BCL2L1_BNIP3_NNMT_TKT_XIAP_ID2_CASP3_SESN2BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_SESN2 ATG12_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BNIP3_TKT_XIAP_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_BECN1_CASP3_SESN2BCL2L1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_CDH2_SESN2BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN1_SESN2 AIFM1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN2 ATG12_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2AIFM1_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 BAX_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BCL2L1_NNMT_ID2_CASP3_CDH2_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_LAMP2_SESN2BCL2L1_NNMT_CDH1_ID2_CASP3_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_AGER_CASP3_SESN2BCL2L1_NNMT_ID2_AGER_CASP3_RAGE_SESN2 AKT1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BNIP3_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 BAX_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2BNIP3_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_PTEN_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2BNIP3_TKT_XIAP_CASP3_HMGB1_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_BECN1_CASP3_SESN2BCL2L1_NNMT_ID2_CASP3_MMP2_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CDH2_SESN2ATG5_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 BCL2L1_CASP8_NNMT_ID2_CASP3_HMGB1_RAGE_SESN2BCL2L1_BNIP3_TKT_ID2_CASP3_RPS19BP1_SESN2 BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN1_SESN2BCL2L1_NNMT_ID2_CASP3_RAGE_SESN1_SESN2 ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG_KIAA1967BCL2L1_NNMT_TKT_ID2_BHLHE41_CASP3_SESN2 BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2_SESN3BCL2L1_PTEN_TKT_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_CSE1L_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BCL2L1_CSE1L_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_STAT3BCL2L1_PTEN_TKT_CASP3_RAGE_SESN1_SESN2 BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2BNIP3_TKT_XIAP_CASP3_CCNG2_RAGE_SESN2 BCL2L1_NNMT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3ATG3_BCL2L1_BNIP3_TKT_CASP3_FASLG_SESN2 BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN1_SESN2BCL2L1_BNIP3_E2F1_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_ID2_HMGB1_HMGB2_SESN1_SESN2BCL2L1_CDH1_ID2_MMP9_TCF3_CASP3_SESN2 BCL2L1_TKT_CDH1_ID2_MMP9_TCF3_CASP3_SESN2。
10.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测A2组的无病存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表9]
一种两种的组合三种的组合四种的组合
SESN2 TKT_SESN2 ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SESN2
TKT BHLHE41_SESN2 FRAP1_SESN2_SIRT1 CSE1L_FRAP1_SESN2_SIRT1
LAMP2 LAMP2_SESN2 ATG5_LC3_SESN2 ATG7_TKT_LAMP2_SESN2
BHLHE41 ATG5_SESN2 ATG5_FRAP1_SESN2 ATG5_FRAP1_SESN2_SIRT1
CSE1L LAMP1_SESN2 TKT_LAMP2_SESN2 AKT1_ATG7_TKT_SESN2
SESN2_SIRT1 AIFM1_TKT_SESN2 ATG5_CSE1L_LC3_SESN2
E2F1_SESN2 ATG5_CSE1L_SESN2 FRAP1_LC3_SESN2_SIRT1
ATG12_SESN2 LC3_SESN2_SIRT1 CSE1L_FRAP1_LAMP1_SESN2
TKT_VEGF ATG12_TKT_SESN2 ATG7_TKT_SESN2_SESN3
CSE1L_BECN1 CSE1L_LAMP1_SESN2 ATG5_FRAP1_LC3_SESN2
CSE1L_SESN2 TKT_HMGB2_SESN2 ATG7_CSE1L_FRAP1_SESN2
ATG7_TKT ATG5_TKT_SESN2 CSE1L_LC3_SESN2_SIRT1
FASLG_SESN2 TKT_CDH1_SESN2 ATG5_LC3_SESN2_SIRT1
PRKAA1_LAMP2 TKT_SESN2_SESN3 ATG7_TKT_FASLG_SESN2
PRKAA1_SESN2 TKT_SESN2_VEGF ATG7_TKT_AGER_SESN2
TKT_BHLHE41 CSE1L_BHLHE41_SESN2 ATG7_TKT_HMGB1_SESN2
CSE1L_BHLHE41 PRKAA1_TKT_SESN2 ATG7_TKT_MMP2_SESN2
ATG7_SESN2 ATG3_TKT_SESN2 BNIP3_CSE1L_FRAP1_SESN2
CSE1L_LAMP2 TKT_RPS19BP1_SESN2 ATG5_ATG7_TKT_SESN2
FAS_SESN2 CBS_TKT_SESN2 ATG7_BCL2_TKT_SESN2
HMGB2_SESN2 CSE1L_LAMP2_SESN2 ATG7_BNIP3_TKT_SESN2
CSE1L_LAMP1 TKT_SESN2_SIRT1 FAS_FRAP1_SESN2_SIRT1
BECN1_SESN2 AKT1_TKT_SESN2 AIFM1_ATG7_TKT_SESN2
NNMT_SESN2 CSE1L_SESN2_SIRT1 ATG12_TKT_LAMP2_SESN2
AIFM1_SESN2 TKT_CDH2_SESN2 ATG7_TKT_BHLHE41_SESN2
BAX_SESN2 BNIP3_TKT_SESN2 ATG7_TKT_ID2_SESN2
DRAM_SESN2 NNMT_TKT_SESN2 CSE1L_DRAM_FRAP1_SESN2
CSE1L_ULK1 TKT_AGER_SESN2 CSE1L_FRAP1_SESN2_UVRAG
KIAA1967_SESN2 TKT_BHLHE41_SESN2 ATG7_LAMP1_TKT_SESN2
SESN2_VEGF TKT_HMGB1_SESN2 ATG7_BCL2L1_TKT_SESN2
BNIP3_SESN2 TKT_MMP2_SESN2 ATG7_TKT_CCNG2_SESN2
SESN2_UVRAG E2F1_TKT_SESN2 CSE1L_E2F1_FRAP1_SESN2
TWIST1_VEGF NAMPT_SESN2_SIRT1 CSE1L_LAMP1_LC3_SESN2
PRKAA1_FASLG TKT_KIAA1967_SESN2 PRKAA1_TKT_LAMP2_SESN2
TKT_RPS19BP1 DRAM_TKT_SESN2 ATG7_CBS_TKT_SESN2
PRKAA1_TKT TKT_CIAP2_SESN2 ATG7_LC3_TKT_SESN2
ATG7_LAMP2 TKT_MMP9_SESN2 ATG7_NNMT_TKT_SESN2
AGER_SESN2 ATG5_NAMPT_SESN2 ATG7_TKT_CIAP2_SESN2
CDH2_SESN2 ATG7_FRAP1_SESN2 ATG7_TKT_SESN2_STAT3
AKT1_PRKAA1 CSE1L_E2F1_SESN2 ATG7_PTEN_TKT_SESN2
ULK1_SESN2 LAMP1_TKT_SESN2 ATG7_TKT_CASP3_SESN2
MMP2_SESN2 LC3_TKT_SESN2 ATG7_TKT_CDH2_SESN2
ATG5_CSE1L TKT_CASP3_SESN2 ATG7_TKT_HMGB2_SESN2
HMGB1_SESN2 TKT_CCNG2_SESN2 ATG7_TKT_NAMPT_SESN2
AKT1_TKT TKT_ID2_SESN2 ATG7_TKT_RAPTOR_SESN2
CBS_SESN2 TKT_RAPTOR_SESN2 ATG7_TKT_SESN2_SIRT1
FRAP1_SESN2 TKT_XIAP_SESN2 ATG7_FRAP1_LC3_SESN2
CIAP2_SESN2 BAX_TKT_SESN2 ATG7_TKT_BECN1_SESN2
BCL2_SESN2 BCL2_TKT_SESN2 ATG7_DIABLO_TKT_SESN2
CCNG2_SESN2 ATG12_CSE1L_SESN2 ATG7_FRAP1_SESN2_SIRT1
BCL2L1_SESN2 BCL2L1_TKT_SESN2 ATG12_CSE1L_FRAP1_SESN2
CSE1L_UVRAG CASP8_TKT_SESN2 ATG7_TKT_XIAP_SESN2
RAPTOR_SESN2 DIABLO_TKT_SESN2 ATG7_E2F1_TKT_SESN2
XIAP_SESN2 FAS_BHLHE41_SESN2 ATG7_TKT_MMP9_SESN2
CASP3_SESN2 FRAP1_TKT_SESN2 ATG7_TKT_RAGE_SESN2
CASP8_SESN2 PTEN_TKT_SESN2 ATG3_ATG7_TKT_SESN2
LC3_SESN2 TKT_RAGE_SESN2 ATG7_CSE1L_LC3_SESN2
五种的组合六种的组合
ATG5_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1
CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1
ATG5_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_FRAP1_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2
ATG7_CSE1L_FRAP1_LC3_SESN2 ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG7_FRAP1_LC3_SESN2_SIRT1 ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_FRAP1_LAMP1_SESN2 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2
AKT1_ATG7_TKT_LAMP2_SESN2 ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1
ATG5_FRAP1_LAMP1_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2
CSE1L_FRAP1_LAMP1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1
ATG3_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2
AKT1_ATG5_CSE1L_FRAP1_SESN2 ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1
ATG5_CSE1L_DIABLO_FRAP1_SESN2 ATG5_CSE1L_FRAP1_LC3_ID2_SESN2
ATG5_CSE1L_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3
CSE1L_FRAP1_SESN2_SIRT1_UVRAG CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG7_TKT_LAMP2_SESN2_SESN3 AKT1_CSE1L_FRAP1_LC3_SESN2_SIRT1
CSE1L_FRAP1_SATB1_SESN2_SIRT1 ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1
CSE1L_FRAP1_CDH1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG7_TKT_FASLG_LAMP2_SESN2 ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG5_CSE1L_FRAP1_ID2_SESN2 CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1
AKT1_ATG7_TKT_SESN2_SESN3 CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1
ATG7_TKT_LAMP2_MMP2_SESN2 CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1
AKT1_CSE1L_FRAP1_SESN2_SIRT1 AKT1_ATG5_FRAP1_LC3_SESN2_SIRT1
BNIP3_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2
ATG5_CSE1L_FRAP1_SESN2_SESN3 ATG5_FRAP1_LC3_ID2_SESN2_SIRT1
CSE1L_FRAP1_LAMP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LAMP1_SESN2_SIRT1
ATG3_ATG5_CSE1L_FRAP1_SESN2 ATG3_ATG7_FRAP1_LC3_SESN2_SIRT1
CSE1L_DRAM_FRAP1_LC3_SESN2 ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1
ATG3_CSE1L_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LAMP1_LC3_SESN2
ATG5_ATG7_FRAP1_LC3_SESN2 ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2
ATG5_FAS_FRAP1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3
CSE1L_FRAP1_SESN2_SESN3_SIRT1 BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1
CSE1L_DRAM_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_SESN2_SIRT1_UVRAG
CSE1L_DIABLO_FRAP1_SESN2_SIRT1 ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2
ATG7_CSE1L_FRAP1_SESN2_SIRT1 ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1
ATG5_CSE1L_FRAP1_CDH1_SESN2 ATG5_ATG7_FRAP1_LAMP1_SESN2_SIRT1
ATG7_TKT_FASLG_SESN2_SESN3 ATG5_CSE1L_FRAP1_CDH1_SESN2_SIRT1
ATG7_TKT_HMGB1_LAMP2_SESN2 ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3
ATG7_TKT_AGER_LAMP2_SESN2 ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2
ATG3_ATG5_FRAP1_LC3_SESN2 ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG3_ATG5_FRAP1_SESN2_SIRT1 ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_FRAP1_SATB1_SESN2 ATG3_ATG5_FRAP1_LAMP1_SESN2_SIRT1
CSE1L_FRAP1_ID2_SESN2_SIRT1 CSE1L_FRAP1_LC3_CDH1_SESN2_SIRT1
ATG7_BNIP3_TKT_LAMP2_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_STAT3
ATG5_ATG7_CSE1L_FRAP1_SESN2 AIFM1_ATG12_TKT_FASLG_LAMP2_SESN2
ATG5_LC3_NAMPT_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_UVRAG
ATG12_ATG5_CSE1L_FRAP1_SESN2 CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1
CSE1L_FRAP1_SESN2_SIRT1_STAT3 CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1
CSE1L_FRAP1_LC3_SESN2_UVRAG ATG5_CSE1L_FRAP1_LC3_RPS19BP1_SESN2
AKT1_ATG7_TKT_MMP2_SESN2 AKT1_ATG5_CSE1L_FRAP1_SESN2_SIRT1
ATG5_BNIP3_CSE1L_FRAP1_SESN2 ATG5_CSE1L_E2F1_FRAP1_LC3_SESN2
CSE1L_FRAP1_MMP9_SESN2_SIRT1 CSE1L_E2F1_FRAP1_LC3_SESN2_SIRT1
BNIP3_CSE1L_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2
AKT1_ATG7_TKT_HMGB1_SESN2 ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2
AIFM1_AKT1_ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SATB1_SESN2_SIRT1
AKT1_ATG5_ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SESN2_SESN3_SIRT1
ATG12_ATG7_TKT_LAMP2_SESN2 ATG7_TKT_FASLG_LAMP2_SESN2_SIRT1
CDH1_ID2_MMP9_TCF3_SESN2 TKT_CDH1_ID2_MMP9_TCF3_SESN2
七种的组合八种的组合
ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_FASLG_HMGB1_LAMP2_SESN2ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAGATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAGATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAGATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG3_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1ATG3_ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG3_ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1_UVRAGAKT1_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1ATG3_ATG5_FRAP1_LC3_ID2_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_CIAP2_FASLG_LAMP2_SESN2ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2ATG5_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAGAIFM1_ATG12_TKT_CDH1_FASLG_LAMP2_SESN2 ATG3_ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1_UVRAGATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3 AKT1_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1AKT1_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1 AIFM1_ATG12_NNMT_CDH2_CIAP2_FASLG_LAMP2_SESN2ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG3_ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SESN3_SIRT1ATG3_ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1_UVRAGATG3_ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_AGER_FASLG_LAMP2_SESN2ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1_UVRAGATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1_UVRAGATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1AIFM1_ATG12_TKT_CIAP2_FASLG_LAMP2_SESN2 ATG3_ATG5_ATG7_FRAP1_LAMP1_LC3_SESN2_SIRT1ATG5_CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1 AKT1_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1ATG7_TKT_FASLG_LAMP2_SESN2_SESN3_SIRT1 AIFM1_DRAM_TKT_CDH1_FASLG_LAMP2_SESN2_SIRT1ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SATB1_SESN2_SIRT1ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_ID2_SATB1_SESN2_SIRT1ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SESN3_SIRT1ATG12_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SESN3_SIRT1AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1ATG5_ATG7_FRAP1_LC3_RPS19BP1_SESN2_SIRT1ATG5_CSE1L_DRAM_FRAP1_LC3_SATB1_SESN2_SIRT1ATG3_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 AIFM1_DRAM_TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 ATG5_ATG7_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2 ATG3_ATG5_DIABLO_DRAM_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3 ATG5_ATG7_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1AKT1_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_MMP9_AGER_FASLG_LAMP2_SESN2_SIRT1AKT1_ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1ATG7_TKT_CDH1_ID2_MMP9_TCF3_SESN2 TKT_CDH1_ID2_MMP9_TCF3_FASLG_SESN2_SIRT1。
11.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测B组的复发预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表10]
一种两种的组合三种的组合四种的组合
HMGB1 ATG3_HMGB1 ATG3_BCL2_HMGB1 ATG3_BCL2_CDH1_HMGB1
TKT ATG3_BECN1 ATG3_HMGB1_RAGE ATG3_CDH1_HMGB1_UVRAG
TKT_HMGB1 ATG3_TKT_HMGB1 ATG3_BCL2_TKT_HMGB1
BCL2L1_TKT ATG3_CDH1_HMGB1 ATG3_BCL2_HMGB1_RAGE
ATG3_NAMPT ATG3_HMGB1_HMGB2 ATG3_BCL2_HMGB1_HMGB2
BCL2_HMGB1 ATG3_HMGB1_UVRAG ATG3_CDH1_HMGB1_SIRT1
HMGB1_TWIST1 ATG3_CASP3_HMGB1 ATG3_BCL2_HMGB1_MMP2
ATG12_ATG3 ATG3_HMGB1_SIRT1 ATG3_HMGB1_HMGB2_RAGE
CSE1L_DIABLO ATG3_BECN1_SATB1 ATG3_BCL2_BNIP3_HMGB1
ATG3_TKT ATG3_HMGB1_SATB1 ATG3_CDH1_CASP3_HMGB1
LAMP1_HMGB1 ATG3_LC3_BECN1 ATG3_CDH1_HMGB1_KIAA1967
TKT_BECN1 ATG3_HMGB1_LAMP2 ATG3_HMGB1_RAGE_UVRAG
CDH1_HMGB1 ATG3_HMGB1_RAPTOR ATG3_HMGB1_RAGE_SIRT1
HMGB1_TP63 ATG3_HMGB1_KIAA1967 ATG3_TKT_HMGB1_HMGB2
TKT_NAMPT BCL2L1_TKT_CASP3 ATG3_TKT_HMGB1_UVRAG
BCL2_TKT ATG12_ATG3_HMGB1 ATG3_BCL2_LAMP1_HMGB1
CSE1L_TKT BCL2L1_TKT_SIRT1 ATG3_BCL2_HMGB1_RAPTOR
LC3_TKT ATG3_CIAP2_HMGB1 AIFM1_ATG3_BCL2_HMGB1
TKT_CASP3 BCL2L1_TKT_BECN1 ATG3_CASP3_HMGB1_RAGE
FASLG_HMGB1 BCL2_TKT_HMGB1 ATG12_ATG3_HMGB1_RAGE
CDH2_HMGB1 ATG3_BECN1_SESN3 ATG3_TKT_CASP3_HMGB1
ATG5_HMGB1 ATG3_CASP8_HMGB1 ATG3_TKT_HMGB1_KIAA1967
HMGB1_SIRT1 ATG3_CDH2_HMGB1 ATG3_BCL2L1_TKT_BECN1
ATG12_HMGB1 ATG3_FRAP1_HMGB1 ATG12_ATG3_CDH1_HMGB1
HMGB1_RAGE ATG3_BNIP3_HMGB1 ATG3_CDH1_HMGB1_RAGE
HMGB1_UVRAG ATG3_BECN1_HMGB1 ATG3_BCL2_FRAP1_HMGB1
BCL2L1_SIRT1 ATG3_CBS_HMGB1 ATG3_BCL2_HMGB1_LAMP2
ATG3_TCF3 AIFM1_ATG3_HMGB1 ATG3_BCL2_DIABLO_HMGB1
BCL2L1_HMGB1 ATG3_HMGB1_STAT3 ATG3_TKT_HMGB1_SIRT1
TKT_SIRT1 ATG3_HMGB1_MMP2 ATG3_BCL2_CBS_HMGB1
HMGB1_LAMP2 ATG3_LAMP1_HMGB1 ATG3_BCL2_CASP8_HMGB1
TKT_SESN2 BCL2L1_TKT_FASLG ATG3_HMGB1_HMGB2_SATB1
HMGB1_MMP2 ATG3_DIABLO_HMGB1 ATG3_BCL2_PTEN_HMGB1
TKT_AGER BCL2_BCL2L1_TKT ATG3_HMGB1_RAGE_RAPTOR
HMGB1_RAPTOR TKT_HMGB1_TWIST1 ATG3_TKT_HMGB1_RAGE
E2F1_HMGB1 ATG3_NNMT_HMGB1 ATG3_BCL2_CASP3_HMGB1
CASP8_HMGB1 ATG3_MMP9_HMGB1 ATG3_BCL2_HMGB1_SATB1
TKT_ID2 BCL2L1_TKT_HMGB1 ATG3_HMGB1_LAMP2_RAGE
AKT1_TKT ATG3_LAMP1_BECN1 ATG3_CDH1_HMGB1_LAMP2
ATG3_SIRT1 ATG3_BCL2L1_BECN1 ATG3_HMGB1_HMGB2_UVRAG
TKT_RPS19BP1 ATG5_TKT_HMGB1 ATG3_BCL2L1_TKT_HMGB1
CSE1L_HMGB1 ATG3_FASLG_HMGB1 CDH1_HMGB1_TP63_UVRAG
BCL2L1_BECN1 ATG3_MMP9_BECN1 ATG3_CDH1_HMGB1_HMGB2
CASP3_HMGB1 ATG3_ATG7_BECN1 ATG3_BCL2L1_TKT_CASP3
ATG7_HMGB1 ATG3_HMGB1_SESN3 ATG3_HMGB1_KIAA1967_RAGE
FRAP1_HMGB1 ATG3_E2F1_HMGB1 ATG3_BCL2_DRAM_HMGB1
HMGB1_HMGB2 HMGB1_RAPTOR_TWIST1 ATG3_LC3_TKT_HMGB1
HMGB1_SATB1 AKT1_ATG3_BECN1 ATG3_BCL2_HMGB1_UVRAG
ATG3_ULK1 ATG3_FAS_HMGB1 ATG3_CDH1_CDH2_HMGB1
ATG3_SESN1 ATG3_ULK1_HMGB1 BCL2_BCL2L1_TKT_CASP3
CBS_HMGB1 TKT_HMGB1_SIRT1 ATG3_TKT_BECN1_HMGB1
TKT_KIAA1967 ATG3_BAX_HMGB1 ATG3_TKT_HMGB1_LAMP2
ATG12_BCL2L1 TKT_CDH2_HMGB1 ATG3_BCL2_PRKAA1_HMGB1
DRAM_HMGB1 ATG3_PTEN_HMGB1 BCL2L1_TKT_CASP3_SIRT1
LC3_FASLG ATG3_TKT_BECN1 BCL2L1_TKT_CASP3_FASLG
HMGB1_KIAA1967 ATG3_HMGB1_TWIST1 BCL2L1_TKT_CASP3_CDH2
TKT_SESN1 BCL2L1_TKT_UVRAG ATG3_BCL2_NNMT_HMGB1
五种的组合六种的组合
ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR
ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE
ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE
ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE
ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR
ATG3_BCL2_BNIP3_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE
ATG3_BCL2_CDH1_HMGB1_LAMP2 ATG3_BCL2_CDH1_HMGB1_RAGE_UVRAG
ATG3_BCL2_CDH1_CDH2_HMGB1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE
ATG3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_CASP3_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG
ATG12_ATG3_BCL2_CDH1_HMGB1 ATG12_ATG3_BCL2_CDH1_HMGB1_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_UVRAG
ATG3_BCL2_CASP8_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAGE
ATG3_BCL2_FRAP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2
ATG3_BCL2_CBS_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2
ATG3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1
ATG3_BCL2_TKT_HMGB1_HMGB2 AIFM1_ATG3_BCL2_CDH1_HMGB1_UVRAG
ATG3_BCL2_CDH1_HMGB1_MMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967
ATG3_BCL2_NNMT_CDH1_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2
ATG3_BCL2_HMGB1_HMGB2_RAGE ATG12_ATG3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_CDH1_MMP9_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAPTOR
ATG12_ATG3_CDH1_HMGB1_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_SIRT1
ATG3_CDH1_HMGB1_LAMP2_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2
ATG3_BCL2_DIABLO_CDH1_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE
ATG3_BCL2L1_TKT_BECN1_CASP3 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967
ATG3_BCL2_HMGB1_MMP2_RAGE ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE
ATG3_CDH1_HMGB1_HMGB2_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2
ATG3_BCL2_DRAM_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_SIRT1
ATG3_BCL2_TKT_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_UVRAG
ATG3_BCL2_TKT_CASP3_HMGB1 ATG3_BCL2_CASP8_CDH1_HMGB1_RAGE
ATG3_CDH1_HMGB1_KIAA1967_UVRAG ATG3_CDH1_HMGB1_LAMP2_RAGE_SIRT1
ATG3_CDH1_HMGB1_LAMP2_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_UVRAG
ATG3_BCL2_BCL2L1_TKT_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_SATB1 ATG3_BCL2_BCL2L1_TKT_HMGB1_SIRT1
ATG3_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_SIRT1
ATG3_BCL2_TKT_ID2_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_RAGE
ATG3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967
ATG3_BCL2_PTEN_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAPTOR
AIFM1_ATG3_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_RAGE_SIRT1_UVRAG
ATG3_BCL2_CDH1_HMGB1_STAT3 ATG3_BCL2_CBS_CDH1_HMGB1_RAGE
ATG3_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_UVRAG
ATG3_BCL2_LC3_TKT_HMGB1 ATG3_BCL2_CBS_CDH1_HMGB1_UVRAG
ATG3_CDH1_CASP3_HMGB1_UVRAG ATG3_CDH1_HMGB1_HMGB2_RAGE_SIRT1
ATG3_BCL2_CDH1_CIAP2_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAPTOR
ATG3_BCL2_BNIP3_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAPTOR
ATG3_CDH1_HMGB1_RAPTOR_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3
ATG3_CDH1_HMGB1_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_RAPTOR_UVRAG
ATG3_CDH1_HMGB1_RAPTOR_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2
ATG3_CDH1_HMGB1_KIAA1967_SIRT1 ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2
ATG3_BAX_BCL2_CDH1_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_SIRT1
ATG3_BCL2_LAMP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_SIRT1
ATG3_ATG5_BCL2_CDH1_HMGB1 AIFM1_ATG3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_TKT_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2
ATG3_CDH1_HMGB1_SATB1_UVRAG ATG3_BCL2_CBS_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_SESN3 ATG3_BCL2_CASP8_CDH1_HMGB1_UVRAG
ATG3_BCL2_FAS_CDH1_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_UVRAG
CDH1_ID2_MMP9_TCF3_FASLG ATG12_ATG3_CDH1_ID2_MMP9_TCF3
七种的组合八种的组合
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAGATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGEATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1 AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_KIAA1967_TWIST1ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGE ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGEATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_UVRAGATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967 ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_TWIST1ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_HMGB2_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAPTORATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGEATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGE ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_KIAA1967AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAGATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTORATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGEAIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAGATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_LAMP2ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_UVRAGATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_KIAA1967AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_LC3_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAGAIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_SIRT1ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_UVRAGATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTOR AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGE ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_UVRAG ATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1 ATG3_LC3_TKT_HMGB1_KIAA1967_RAGE_TWIST1_UVRAGATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_KIAA1967AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTORATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTORATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_UVRAGATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_UVRAGATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGE ATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGEATG12_ATG3_CDH1_ID2_MMP9_TCF3_SATB1 ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG。
12.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测B组的存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表11]
一种两种的组合三种的组合四种的组合
ATG12 DIABLO_NAMPT DIABLO_ID2_NAMPT ATG12_ID2_MMP9_TCF3
DIABLO ATG12_ID2 DIABLO_FAS_NAMPT DIABLO_FAS_ID2_NAMPT
UVRAG ATG12_RPS19BP1 ATG12_ID2_TCF3 ATG12_CSE1L_ID2_MMP9
NAMPT ATG12_DIABLO DIABLO_FAS_STAT3 DIABLO_ID2_MMP9_NAMPT
STAT3 ID2_NAMPT ATG12_ID2_MMP9 DIABLO_FAS_MMP9_NAMPT
E2F1 DIABLO_STAT3 ATG12_ID2_SATB1 DIABLO_ID2_NAMPT_STAT3
BECN1 DIABLO_FAS ATG12_ID2_RPS19BP1 ATG12_FAS_ID2_MMP9
FRAP1 ATG12_CSE1L ATG12_CSE1L_ID2 ATG12_ID2_MMP9_SATB1
ATG7 ATG12_MMP9 ATG12_DIABLO_FAS DIABLO_ID2_NAMPT_SATB1
ID2 ATG12_ATG3 ATG12_ID2_SESN2 ATG12_ID2_MMP9_SESN2
SIRT1 ATG12_SATB1 ATG12_ID2_NAMPT ATG12_ID2_MMP9_RPS19BP1
BCL2 ATG12_SESN2 ATG12_CSE1L_DIABLO CSE1L_DIABLO_ID2_NAMPT
BNIP3 CSE1L_DIABLO ID2_NAMPT_STAT3 DIABLO_ID2_TCF3_NAMPT
LAMP2 ATG12_TCF3 ATG12_ID2_BHLHE41 DIABLO_FAS_NAMPT_SATB1
TKT ATG12_FAS CSE1L_DIABLO_NAMPT ATG12_DIABLO_FAS_MMP9
ATG12_STAT3 DIABLO_LC3_NAMPT DIABLO_FAS_ID2_STAT3
ATG12_BHLHE41 ATG12_FAS_ID2 ATG12_ATG3_ID2_TCF3
ATG12_NAMPT ID2_NAMPT_RPS19BP1 ATG3_DIABLO_ID2_NAMPT
ATG12_ATG7 ID2_MMP9_TCF3 ATG12_ID2_TCF3_STAT3
ID2_BECN1 DIABLO_NAMPT_SATB1 DIABLO_FAS_NAMPT_STAT3
E2F1_FAS ATG12_CSE1L_MMP9 ATG12_CSE1L_DIABLO_MMP9
ATG12_ATG5 ATG12_MMP9_RPS19BP1 ATG12_ID2_TCF3_SATB1
ID2_STAT3 ID2_MMP9_BECN1 DIABLO_FAS_MMP9_STAT3
ATG12_ULK1 DIABLO_NAMPT_STAT3 ATG12_ID2_MMP9_BHLHE41
DIABLO_BECN1 ATG12_DIABLO_MMP9 ATG12_BNIP3_ID2_MMP9
ATG12_LAMP1 ATG12_FAS_RPS19BP1 DIABLO_FAS_SATB1_STAT3
ATG12_LC3 DIABLO_FAS_MMP9 DIABLO_FAS_NAMPT_RPS19BP1
DIABLO_TCF3 ID2_MMP9_NAMPT ATG12_ATG3_ID2_MMP9
AKT1_ATG12 ATG12_ID2_STAT3 ATG12_ID2_MMP9_NAMPT
ATG12_FRAP1 ATG12_DIABLO_TCF3 DIABLO_FAS_NAMPT_SESN2
DIABLO_ID2 ATG12_ATG3_ID2 DIABLO_ID2_NAMPT_SESN2
ID2_TCF3 ATG12_DIABLO_ID2 ATG12_ID2_TCF3_RPS19BP1
DIABLO_SATB1 CSE1L_DIABLO_STAT3 ATG12_DIABLO_MMP9_TCF3
ATG12_BECN1 DIABLO_ID2_STAT3 ATG12_CSE1L_ID2_SATB1
ATG12_SIRT1 ATG12_ATG3_RPS19BP1 ATG12_FAS_MMP9_RPS19BP1
NAMPT_STAT3 ATG12_DIABLO_SATB1 ID2_MMP9_TCF3_STAT3
ATG12_BNIP3 ATG12_MMP9_TCF3 ATG12_DIABLO_ID2_NAMPT
DIABLO_MMP9 ATG3_DIABLO_NAMPT DIABLO_ID2_TCF3_STAT3
ATG12_UVRAG ATG12_DIABLO_NAMPT ATG12_ULK1_ID2_TCF3
DIABLO_FRAP1 ATG12_CSE1L_RPS19BP1 ATG12_ID2_TCF3_SESN2
NAMPT_RPS19BP1 DIABLO_MMP9_NAMPT BNIP3_CSE1L_DIABLO_MMP9
AKT1_NAMPT ATG12_ATG3_DIABLO ATG12_DIABLO_ID2_TCF3
E2F1_UVRAG DIABLO_SATB1_STAT3 ATG12_ATG5_ID2_MMP9
ATG3_DIABLO ID2_TCF3_STAT3 ATG12_ID2_SATB1_STAT3
NAMPT_UVRAG ATG12_RPS19BP1_SATB1 ATG12_MMP9_TCF3_RPS19BP1
BNIP3_DIABLO ATG12_DIABLO_STAT3 ATG12_DIABLO_FAS_ID2
DIABLO_LC3 ATG12_TCF3_RPS19BP1 ATG12_CSE1L_ID2_SESN2
DIABLO_SIRT1 DIABLO_NAMPT_SESN2 DIABLO_FAS_MMP9_TCF3
LC3_NAMPT ATG12_DIABLO_SESN2 ATG12_ID2_TCF3_BHLHE41
DIABLO_SESN2 ATG12_ULK1_ID2 ATG12_FAS_ID2_STAT3
FAS_STAT3 ATG12_ATG5_ID2 BNIP3_CSE1L_ID2_MMP9
FAS_NAMPT AKT1_DIABLO_NAMPT CSE1L_DIABLO_FAS_NAMPT
E2F1_NAMPT ATG12_ID2_BECN1 ATG12_CSE1L_ID2_TCF3
ATG12_SESN3 ATG12_FAS_MMP9 ATG12_ID2_NAMPT_RPS19BP1
BCL2_TKT ATG12_DIABLO_BHLHE41 ATG12_ID2_MMP9_BECN1
ATG7_NAMPT ATG12_RPS19BP1_STAT3 DIABLO_FAS_LC3_NAMPT
ATG7_BECN1 DIABLO_NAMPT_RPS19BP1 FAS_ID2_NAMPT_RPS19BP1
CDH1_ID2_MMP9_TCF3
五种的组合六种的组合
DIABLO_FAS_ID2_MMP9_NAMPT DIABLO_FAS_ID2_MMP9_TCF3_NAMPT
ATG12_ATG3_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3
ATG12_ID2_MMP9_TCF3_SATB1 ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1
ATG12_CSE1L_ID2_MMP9_TCF3 ATG12_ATG3_ID2_MMP9_TCF3_SATB1
ATG12_BNIP3_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_SATB1
ATG12_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ULK1_ID2_MMP9_TCF3
ATG12_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_CSE1L_ID2_MMP9_SESN2
ATG12_ATG5_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_STAT3
ATG12_FAS_ID2_MMP9_TCF3 ATG12_ATG3_FAS_ID2_MMP9_TCF3
DIABLO_FAS_ID2_NAMPT_STAT3 ATG12_ATG3_ID2_MMP9_TCF3_SESN2
ATG12_ID2_MMP9_TCF3_RPS19BP1 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3
ATG12_BNIP3_ID2_MMP9_RPS19BP1 CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT
ATG12_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_CSE1L_ID2_MMP9_TCF3
ATG12_CSE1L_ID2_MMP9_SESN2 ATG12_BNIP3_ID2_MMP9_TCF3_SATB1
ATG12_LAMP1_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_SESN2
DIABLO_FAS_ID2_NAMPT_SATB1 ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41
ATG12_BNIP3_CSE1L_ID2_MMP9 ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1
DIABLO_ID2_MMP9_TCF3_NAMPT DIABLO_FAS_ID2_MMP9_TCF3_STAT3
ATG12_BNIP3_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9
ATG12_ID2_MMP9_TCF3_BHLHE41 ATG12_ATG3_BNIP3_ID2_MMP9_SATB1
ATG12_ID2_MMP9_TCF3_STAT3 ATG12_BNIP3_CSE1L_ID2_MMP9_RPS19BP1
ATG12_BNIP3_FAS_ID2_MMP9 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9
ATG12_BNIP3_ID2_MMP9_SESN2 ATG12_BNIP3_FAS_ID2_MMP9_RPS19BP1
ATG12_ATG3_FAS_ID2_MMP9 ATG12_CSE1L_ID2_MMP9_TCF3_SATB1
CSE1L_DIABLO_ID2_MMP9_NAMPT ATG12_CSE1L_ULK1_ID2_MMP9_TCF3
ATG12_DIABLO_ID2_MMP9_TCF3 ATG12_FAS_ID2_MMP9_TCF3_RPS19BP1
DIABLO_ID2_NAMPT_SATB1_STAT3 DIABLO_FAS_ID2_NAMPT_SATB1_STAT3
ATG12_ATG3_CSE1L_ID2_MMP9 ATG12_ATG5_BNIP3_ID2_MMP9_TCF3
ATG12_FAS_ID2_MMP9_RPS19BP1 ATG12_BNIP3_ID2_MMP9_TCF3_SESN2
ATG12_DIABLO_FAS_ID2_MMP9 ATG12_CSE1L_ID2_MMP9_TCF3_SESN2
DIABLO_FAS_ID2_MMP9_STAT3 ATG12_ID2_MMP9_TCF3_SATB1_SESN2
ATG12_CSE1L_ID2_MMP9_BHLHE41 ATG12_ULK1_ID2_MMP9_TCF3_SATB1
DIABLO_ID2_MMP9_NAMPT_STAT3 ATG12_ATG3_ATG5_ID2_MMP9_TCF3
DIABLO_FAS_ID2_NAMPT_SESN2 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9
ATG12_CSE1L_FAS_ID2_MMP9 ATG12_ATG3_LAMP1_ID2_MMP9_TCF3
DIABLO_FAS_ID2_TCF3_NAMPT ATG12_BNIP3_DIABLO_ID2_MMP9_TCF3
ATG12_ATG3_ID2_MMP9_SATB1 ATG12_BNIP3_ULK1_ID2_MMP9_TCF3
ATG12_BNIP3_ID2_MMP9_BHLHE41 ATG12_DIABLO_FAS_ID2_MMP9_TCF3
ATG3_DIABLO_FAS_ID2_NAMPT ATG12_ULK1_ID2_MMP9_TCF3_SESN2
CSE1L_DIABLO_FAS_ID2_NAMPT ATG3_DIABLO_FAS_ID2_MMP9_NAMPT
ATG12_CSE1L_ID2_MMP9_RPS19BP1 ATG12_ATG3_BNIP3_ID2_MMP9_SESN2
ATG12_CSE1L_ULK1_ID2_MMP9 ATG12_ATG3_ID2_MMP9_TCF3_BHLHE41
DIABLO_FAS_ID2_MMP9_TCF3 ATG12_BNIP3_CSE1L_FAS_ID2_MMP9
CSE1L_DIABLO_ID2_NAMPT_STAT3 DIABLO_ID2_MMP9_TCF3_NAMPT_SATB1
ATG12_ATG3_ID2_MMP9_SESN2 ATG12_ATG3_BNIP3_ID2_MMP9_RPS19BP1
DIABLO_ID2_MMP9_TCF3_STAT3 ATG12_ATG5_ID2_MMP9_TCF3_SATB1
DIABLO_ID2_TCF3_NAMPT_SATB1 ATG12_BNIP3_FAS_ID2_MMP9_TCF3
CSE1L_DIABLO_FAS_MMP9_NAMPT ATG12_ATG3_CSE1L_ID2_MMP9_SATB1
DIABLO_FAS_ID2_NAMPT_RPS19BP1 ATG12_ATG3_ID2_MMP9_TCF3_STAT3
BNIP3_DIABLO_FAS_ID2_MMP9 ATG12_ATG5_BNIP3_ID2_MMP9_SATB1
DIABLO_ID2_MMP9_NAMPT_SATB1 ATG12_BNIP3_ID2_MMP9_TCF3_BHLHE41
ATG12_DIABLO_FAS_MMP9_TCF3 ATG12_FAS_ID2_MMP9_TCF3_SESN2
ATG12_ATG5_FAS_ID2_MMP9 DIABLO_FAS_ID2_MMP9_NAMPT_RPS19BP1
ATG12_LC3_ID2_MMP9_TCF3 ATG12_ATG3_CSE1L_ID2_MMP9_SESN2
ATG12_FAS_ID2_MMP9_STAT3 ATG12_ATG3_ID2_MMP9_TCF3_RPS19BP1
FAS_ID2_MMP9_NAMPT_RPS19BP1 ATG12_ATG5_BNIP3_FAS_ID2_MMP9
ATG12_ID2_MMP9_TCF3_BECN1 ATG12_ATG5_ULK1_ID2_MMP9_TCF3
ATG12_CDH1_ID2_MMP9_TCF3 E2F1_FAS_CDH1_ID2_MMP9_TCF3
七种的组合八种的组合
DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SESN2 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_STAT3DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_SESN2ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_SESN2ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_STAT3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_STAT3 ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2ATG12_ATG3_BNIP3_FAS_ID_MMP9_TCF3 ATG3_BCL2_E2F1_LAMP1_TKT_MMP9_CASP3_HMGB1ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_CSE1L_DIABLO_FAS_ID2_MMP9ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_BHLHE41ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_SATB1ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_SATB1ATG12_ATG3_ID2_MMP9_TCF3_SATB1_SESN2 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_SESN2DIABLO_FAS_ID2_MMP9_TCF3_SATB1_STAT3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41_SATB1ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9 ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_SESN2ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1_SESN2ATG12_BNIP3_CSE1L_DIABLO_FAS_ID2_MMP9 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_SATB1ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SESN2 ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_SATB1CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_STAT3 ATG12_BNIP3_FAS_ULK1_ID2_MMP9_TCF3_RPS19BP1ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9 CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_STAT3ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_TCF3ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_SESN2ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2 ATG12_ATG3_ATG5_BNIP3_ULK1_ID2_MMP9_TCF3ATG12_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_RPS19BP1ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_SATB1ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SESN2ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1 ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_SATB1ATG12_ATG3_FAS_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_SESN2ATG12_ATG3_FAS_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_RPS19BP1ATG12_ATG3_FAS_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_TCF3ATG12_ATG3_FAS_ULK1_ID2_MMP9_TCF3 ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_SATB1 ATG12_ATG5_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_RPS19BP1 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1_SESN2ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SESN2 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3_SATB1ATG12_ATG3_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_SESN2ATG12_BNIP3_CSE1L_FAS_ID2_MMP9_RPS19BP1 ATG12_BNIP3_DIABLO_FAS_ULK1_ID2_MMP9_TCF3ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1 ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_SESN2ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41 ATG3_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1ATG12_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2_STAT3ATG12_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1 DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2_STAT3DIABLO_FAS_ID2_MMP9_NAMPT_SESN2_STAT3 ATG12_ATG3_ATG5_BNIP3_CSE1L_FAS_ID2_MMP9CSE1L_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_BHLHE41DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_TCF3CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_RPS19BP1ATG12_ATG3_BNIP3_DIABLO_ID2_MMP9_TCF3 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_FAS_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_SESN2ATG3_TKT_CDH1_ID2_MMP9_TCF3_UVRAG ATG3_TKT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG。
13.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测B组的无病存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表12]
一种两种的组合三种的组合四种的组合
DIABLO ATG3_BECN1 ATG3_BCL2_HMGB1 ATG3_BCL2_CDH1_HMGB1
BECN1 ATG3_HMGB1 ATG3_HMGB1_RAGE ATG3_CDH1_HMGB1_UVRAG
HMGB1 BCL2L1_TKT ATG3_HMGB1_UVRAG ATG3_BCL2_TKT_HMGB1
CSE1L_DIABLO ATG3_CASP3_HMGB1 ATG3_BCL2_HMGB1_RAGE
BCL2_HMGB1 ATG3_HMGB1_SIRT1 ATG3_BCL2_HMGB1_HMGB2
ATG12_ATG3 ATG3_BECN1_SATB1 ATG3_CDH1_HMGB1_SIRT1
ATG3_NAMPT ATG3_HMGB1_LAMP2 ATG3_BCL2_HMGB1_MMP2
HMGB1_TWIST1 ATG3_HMGB1_RAPTOR ATG3_HMGB1_HMGB2_RAGE
TKT_HMGB1 ATG3_LC3_BECN1 ATG3_BCL2_BNIP3_HMGB1
LAMP1_HMGB1 ATG3_HMGB1_KIAA1967 ATG3_CDH1_CASP3_HMGB1
TKT_BECN1 BCL2L1_TKT_CASP3 ATG3_CDH1_HMGB1_KIAA1967
HMGB1_TP63 ATG12_ATG3_HMGB1 ATG3_HMGB1_RAGE_UVRAG
BCL2_TKT BCL2L1_TKT_SIRT1 ATG3_HMGB1_RAGE_SIRT1
TKT_CASP3 BCL2L1_TKT_BECN1 ATG3_TKT_HMGB1_UVRAG
FASLG_HMGB1 BCL2_TKT_HMGB1 ATG3_BCL2_LAMP1_HMGB1
TKT_NAMPT ATG3_BECN1_SESN3 ATG3_BCL2_HMGB1_RAPTOR
ATG5_HMGB1 ATG3_BNIP3_HMGB1 AIFM1_ATG3_BCL2_HMGB1
HMGB1_SIRT1 ATG3_BECN1_HMGB1 ATG3_CASP3_HMGB1_RAGE
ATG12_HMGB1 AIFM1_ATG3_HMGB1 ATG12_ATG3_HMGB1_RAGE
HMGB1_RAGE ATG3_LAMP1_HMGB1 ATG3_TKT_CASP3_HMGB1
DIABLO_NAMPT BCL2L1_TKT_FASLG ATG3_TKT_HMGB1_KIAA1967
HMGB1_UVRAG BCL2_BCL2L1_TKT ATG3_BCL2L1_TKT_BECN1
DIABLO_BECN1 TKT_HMGB1_TWIST1 ATG12_ATG3_CDH1_HMGB1
BECN1_SATB1 ATG3_NNMT_HMGB1 ATG3_CDH1_HMGB1_RAGE
BCL2L1_SIRT1 BCL2L1_TKT_HMGB1 ATG3_BCL2_FRAP1_HMGB1
BCL2L1_HMGB1 ATG3_BCL2L1_BECN1 ATG3_BCL2_HMGB1_LAMP2
TKT_SIRT1 ATG5_TKT_HMGB1 ATG3_BCL2_DIABLO_HMGB1
DIABLO_TCF3 ATG3_FASLG_HMGB1 ATG3_TKT_HMGB1_SIRT1
HMGB1_LAMP2 ATG3_MMP9_BECN1 ATG3_BCL2_CBS_HMGB1
DIABLO_SATB1 ATG3_LAMP1_BECN1 ATG3_BCL2_CASP8_HMGB1
HMGB1_RAPTOR ATG3_E2F1_HMGB1 ATG3_BCL2_PTEN_HMGB1
E2F1_HMGB1 HMGB1_RAPTOR_TWIST1 ATG3_HMGB1_RAGE_RAPTOR
ATG5_BECN1 AKT1_ATG3_BECN1 ATG3_TKT_HMGB1_RAGE
ATG12_SATB1 ATG3_ULK1_HMGB1 ATG3_BCL2_CASP3_HMGB1
BCL2L1_BECN1 TKT_HMGB1_SIRT1 ATG3_BCL2_HMGB1_SATB1
CASP3_HMGB1 ATG3_BAX_HMGB1 ATG3_HMGB1_LAMP2_RAGE
ATG12_CSE1L ATG3_PTEN_HMGB1 ATG3_CDH1_HMGB1_LAMP2
ATG7_HMGB1 ATG3_TKT_HMGB1 ATG3_HMGB1_HMGB2_UVRAG
ATG3_SIRT1 ATG3_TKT_BECN1 ATG3_BCL2L1_TKT_HMGB1
CASP8_HMGB1 ATG3_HMGB1_TWIST1 CDH1_HMGB1_TP63_UVRAG
ATG3_SESN1 BCL2L1_TKT_UVRAG ATG3_BCL2L1_TKT_CASP3
TKT_KIAA1967 TKT_HMGB1_UVRAG ATG3_HMGB1_KIAA1967_RAGE
ATG12_BCL2L1 BCL2L1_TKT_CDH2 ATG3_BCL2_DRAM_HMGB1
DRAM_HMGB1 BCL2L1_TKT_KIAA1967 ATG3_BCL2_HMGB1_UVRAG
LC3_FASLG ATG3_BCL2L1_HMGB1 BCL2_BCL2L1_TKT_CASP3
HMGB1_KIAA1967 ATG3_ATG5_HMGB1 ATG3_TKT_BECN1_HMGB1
TKT_SESN1 ATG3_DRAM_HMGB1 ATG3_TKT_HMGB1_LAMP2
ATG3_DIABLO ATG3_HMGB1_SATB1 ATG3_BCL2_PRKAA1_HMGB1
DIABLO_SIRT1 ATG3_BCL2L1_TKT BCL2L1_TKT_CASP3_SIRT1
BECN1_HMGB1 ATG3_PRKAA1_HMGB1 BCL2L1_TKT_CASP3_FASLG
AIFM1_HMGB1 TKT_CASP3_HMGB1 BCL2L1_TKT_CASP3_CDH2
ID2_BECN1 ATG3_XIAP_HMGB1 ATG3_BCL2_NNMT_HMGB1
CSE1L_BECN1 TKT_HMGB1_KIAA1967 ATG3_CDH1_HMGB1_RAPTOR
TKT_ULK1 TKT_HMGB1_LAMP2 ATG3_BNIP3_HMGB1_RAGE
BNIP3_HMGB1 HMGB1_RAGE_TWIST1 ATG3_BAX_BCL2_HMGB1
TKT_UVRAG ATG12_BCL2L1_TKT ATG3_BCL2_ID2_HMGB1
ATG5_TKT ATG3_PTEN_BECN1 ATG3_BCL2_HMGB1_STAT3
五种的组合六种的组合
ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR
ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE
ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE
ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE
ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR
ATG3_BCL2_BNIP3_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE
ATG3_BCL2_CDH1_HMGB1_LAMP2 ATG3_BCL2_CDH1_HMGB1_RAGE_UVRAG
ATG3_BCL2_CDH1_CDH2_HMGB1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE
ATG3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_CASP3_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG
ATG12_ATG3_BCL2_CDH1_HMGB1 ATG12_ATG3_BCL2_CDH1_HMGB1_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_UVRAG
ATG3_BCL2_CASP8_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAGE
ATG3_BCL2_FRAP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2
ATG3_BCL2_CBS_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2
ATG3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1
ATG3_BCL2_TKT_HMGB1_HMGB2 AIFM1_ATG3_BCL2_CDH1_HMGB1_UVRAG
ATG3_BCL2_CDH1_HMGB1_MMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967
ATG3_BCL2_NNMT_CDH1_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2
ATG3_BCL2_HMGB1_HMGB2_RAGE ATG12_ATG3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_CDH1_MMP9_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAPTOR
ATG12_ATG3_CDH1_HMGB1_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_SIRT1
ATG3_CDH1_HMGB1_LAMP2_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2
ATG3_BCL2_DIABLO_CDH1_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE
ATG3_BCL2L1_TKT_BECN1_CASP3 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967
ATG3_BCL2_HMGB1_MMP2_RAGE ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE
ATG3_CDH1_HMGB1_HMGB2_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2
ATG3_BCL2_DRAM_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_SIRT1
ATG3_BCL2_TKT_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_UVRAG
ATG3_BCL2_TKT_CASP3_HMGB1 ATG3_BCL2_CASP8_CDH1_HMGB1_RAGE
ATG3_CDH1_HMGB1_KIAA1967_UVRAG ATG3_CDH1_HMGB1_LAMP2_RAGE_SIRT1
ATG3_CDH1_HMGB1_LAMP2_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_UVRAG
ATG3_BCL2_BCL2L1_TKT_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_SATB1 ATG3_BCL2_BCL2L1_TKT_HMGB1_SIRT1
ATG3_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_SIRT1
ATG3_BCL2_TKT_ID2_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_RAGE
ATG3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967
ATG3_BCL2_PTEN_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAPTOR
AIFM1_ATG3_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_RAGE_SIRT1_UVRAG
ATG3_BCL2_CDH1_HMGB1_STAT3 ATG3_BCL2_CBS_CDH1_HMGB1_RAGE
ATG3_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_UVRAG
ATG3_BCL2_LC3_TKT_HMGB1 ATG3_BCL2_CBS_CDH1_HMGB1_UVRAG
ATG3_CDH1_CASP3_HMGB1_UVRAG ATG3_CDH1_HMGB1_HMGB2_RAGE_SIRT1
ATG3_BCL2_CDH1_CIAP2_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAPTOR
ATG3_BCL2_BNIP3_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAPTOR
ATG3_CDH1_HMGB1_RAPTOR_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3
ATG3_CDH1_HMGB1_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_RAPTOR_UVRAG
ATG3_CDH1_HMGB1_RAPTOR_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2
ATG3_CDH1_HMGB1_KIAA1967_SIRT1 ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2
ATG3_BAX_BCL2_CDH1_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_SIRT1
ATG3_BCL2_LAMP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_SIRT1
ATG3_ATG5_BCL2_CDH1_HMGB1 AIFM1_ATG3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_TKT_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2
ATG3_CDH1_HMGB1_SATB1_UVRAG ATG3_BCL2_CBS_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_SESN3 ATG3_BCL2_CASP8_CDH1_HMGB1_UVRAG
ATG3_BCL2_FAS_CDH1_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_UVRAG
CDH1_ID2_MMP9_TCF3_FASLG ATG12_ATG3_CDH1_ID2_MMP9_TCF3
七种的组合八种的组合
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAGATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGEATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1 AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_KIAA1967_TWIST1ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGE ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGEATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_UVRAGATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967 ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_TWIST1ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_HMGB2_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAPTORATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGEATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGE ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_KIAA1967AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAGATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTORATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGEAIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAGATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_LAMP2ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_UVRAGATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_KIAA1967AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_LC3_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAGAIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_SIRT1ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_UVRAGATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTOR AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGE ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_CDH1_HMGB1_MMP2_RAGEUVRAG ATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1 ATG3_LC3_TKT_HMGB1_KIAA1967_RAGE_TWIST1_UVRAGATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_KIAA1967AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTORATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTORATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_UVRAGATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1 ATG3BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_UVRAGATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGE ATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGENNMT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG。
14.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测C组的复发预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表13]
一种两种的组合三种的组合四种的组合
FASLG CIAP2_FASLG FAS_LC3_FASLG DIABLO_FAS_LC3_FASLG
CIAP2 E2F1_FASLG DIABLO_FAS_FASLG FAS_LC3_FASLG_UVRAG
CSE1L LC3_FASLG E2F1_LC3_FASLG BNIP3_FAS_LC3_FASLG
FAS DIABLO_FASLG FAS_FASLG_RPS19BP1 DRAM_FAS_LC3_FASLG
TCF3 FAS_FASLG E2F1_FAS_FASLG E2F1_FAS_LC3_FASLG
FASLG_RPS19BP1 FAS_FASLG_UVRAG ATG3_FAS_LC3_FASLG
PTEN_FASLG DIABLO_LC3_FASLG ATG7_FAS_LC3_FASLG
CASP3_FASLG ATG7_FAS_FASLG FAS_LC3_FASLG_STAT3
FASLG_SESN2 CIAP2_FASLG_SESN3 FAS_FRAP1_LC3_FASLG
FASLG_HMGB1 CIAP2_FASLG_UVRAG FAS_LC3_FASLG_SESN3
CDH2_FASLG BNIP3_LC3_FASLG FAS_LC3_FASLG_SIRT1
FRAP1_FASLG LC3_CIAP2_FASLG FAS_LC3_BECN1_FASLG
ATG7_FASLG LC3_FASLG_SESN2 ATG5_FAS_LC3_FASLG
ATG3_FAS FRAP1_LC3_FASLG FAS_LC3_FASLG_RPS19BP1
FASLG_HMGB2 LC3_FASLG_SESN3 FAS_LAMP1_LC3_FASLG
FASLG_UVRAG ATG3_FAS_FASLG FAS_LC3_FASLG_NAMPT
DIABLO_FAS ATG7_LC3_FASLG AKT1_FAS_LC3_FASLG
FASLG_MMP2 FAS_FRAP1_FASLG FAS_LC3_FASLG_SESN2
TKT_FASLG DIABLO_FASLG_SESN2 FAS_LC3_MMP9_FASLG
PTEN_CIAP2 DRAM_LC3_FASLG FAS_FASLG_RPS19BP1_SESN3
FAS_LC3 CIAP2_FASLG_HMGB1 FAS_FASLG_RPS19BP1_UVRAG
CBS_FASLG FAS_FASLG_SESN3 FAS_LC3_CDH1_FASLG
AIFM1_FASLG LC3_FASLG_UVRAG ATG12_FAS_LC3_FASLG
CASP3_CIAP2 CASP3_CIAP2_FASLG DIABLO_FAS_FASLG_SESN3
FASLG_SESN3 FAS_FASLG_SESN2 DIABLO_FAS_FASLG_UVRAG
ATG3_FASLG PTEN_CIAP2_FASLG FAS_LC3_FASLG_LAMP2
CASP8_FASLG DIABLO_FASLG_SESN3 FAS_LC3_ID2_FASLG
XIAP_FASLG ATG7_CIAP2_FASLG DIABLO_FAS_FASLG_SESN2
AGER_FASLG LC3_FASLG_SIRT1 FAS_LC3_BHLHE41_FASLG
ATG3_ULK1 LC3_FASLG_RPS19BP1 DIABLO_DRAM_FAS_FASLG
BNIP3_FASLG FASLG_SESN2_SESN3 DIABLO_FAS_FASLG_STAT3
FAS_UVRAG DRAM_FAS_FASLG DRAM_FAS_FASLG_RPS19BP1
CIAP2_RAGE ID2_CIAP2_FASLG DIABLO_FAS_FRAP1_FASLG
ATG3_TCF3 FAS_FASLG_STAT3 FAS_FASLG_SESN2_UVRAG
FASLG_RAGE AKT1_CIAP2_FASLG ATG3_FAS_FASLG_SESN2
E2F1_CIAP2 DIABLO_FRAP1_FASLG ATG7_DIABLO_FAS_FASLG
FASLG_VEGF BNIP3_FAS_FASLG FAS_LC3_TCF3_FASLG
E2F1_FAS FAS_LAMP1_FASLG ATG7_FAS_FASLG_UVRAG
XIAP_CIAP2 TKT_CIAP2_FASLG DIABLO_FAS_FASLG_NAMPT
BCL2L1_FASLG ATG7_DIABLO_FASLG DIABLO_FAS_FASLG_SIRT1
BNIP3_FAS FRAP1_FASLG_SESN2 DIABLO_FAS_LAMP1_FASLG
FASLG_SESN1 E2F1_ULK1_FASLG FAS_FRAP1_FASLG_RPS19BP1
FASLG_KIAA1967 DRAM_CIAP2_FASLG CSE1L_FAS_LC3_FASLG
AIFM1_CIAP2 PTEN_CASP3_FASLG DIABLO_FAS_BECN1_FASLG
DRAM_FASLG LC3_FASLG_NAMPT E2F1_LC3_ID2_FASLG
ATG3_CIAP2 PTEN_CDH1_CIAP2 AKT1_DIABLO_FAS_FASLG
CSE1L_FASLG ATG12_CIAP2_FASLG ATG3_DIABLO_FAS_FASLG
FASLG_RAPTOR FASLG_RPS19BP1_SESN3 E2F1_FAS_FASLG_SESN3
TCF3_FASLG MMP9_CIAP2_FASLG ATG7_FAS_FASLG_SESN2
FASLG_STAT3 LAMP1_CIAP2_FASLG DIABLO_FAS_FASLG_RPS19BP1
ULK1_FASLG LC3_BECN1_FASLG DRAM_FAS_FASLG_UVRAG
PRKAA1_CIAP2 CDH1_CIAP2_FASLG LC3_MMP9_FASLG_SESN2
FASLG_SIRT1 BECN1_CIAP2_FASLG FAS_FASLG_SESN3_UVRAG
ATG12_FASLG CIAP2_FASLG_HMGB2 DIABLO_FAS_FASLG_LAMP2
LAMP1_FASLG E2F1_FASLG_LAMP2 DIABLO_FAS_ID2_FASLG
NNMT_FASLG CIAP2_FASLG_SIRT1 E2F1_LC3_FASLG_LAMP2
BCL2L1_CIAP2 PTEN_XIAP_FASLG E2F1_LC3_MMP9_FASLG
CDH1_ID2_MMP9_TCF3
五种的组合六种的组合
BNIP3_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_SESN2
DRAM_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_FASLG_SESN3
DIABLO_DRAM_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2
ATG3_FAS_LC3_FASLG_SESN3 ATG3_FAS_LC3_MMP9_FASLG_SESN3
BNIP3_FAS_LC3_FASLG_SESN3 ATG3_FAS_LC3_FASLG_SESN2_SESN3
BNIP3_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG
ATG3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_STAT3
BNIP3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_UVRAG
DRAM_FAS_LC3_FASLG_STAT3 BNIP3_DRAM_FAS_LC3_FASLG_SIRT1
DIABLO_FAS_LC3_BECN1_FASLG ATG3_DRAM_FAS_LC3_FASLG_SESN2
BNIP3_DIABLO_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_BECN1_FASLG
ATG7_DRAM_FAS_LC3_FASLG DRAM_FAS_LC3_ID2_FASLG_UVRAG
DIABLO_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_MMP9_FASLG_UVRAG
DRAM_FAS_LC3_FASLG_SIRT1 DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1
DRAM_E2F1_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_UVRAG
DRAM_FAS_LC3_FASLG_SESN3 DRAM_FAS_LC3_FASLG_SIRT1_UVRAG
DRAM_FAS_LC3_BECN1_FASLG DRAM_FAS_LC3_MMP9_FASLG_UVRAG
BNIP3_FAS_LC3_FASLG_STAT3 BNIP3_DRAM_FAS_LC3_ID2_FASLG
BNIP3_FAS_LC3_MMP9_FASLG ATG3_DRAM_FAS_LC3_FASLG_SESN3
DIABLO_FAS_LC3_ID2_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN3
DIABLO_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN2
ATG5_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_BECN1_FASLG_UVRAG
ATG5_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_FRAP1_LC3_FASLG
DIABLO_FAS_LC3_FASLG_SIRT1 BNIP3_FAS_LC3_FASLG_SESN3_SIRT1
FAS_LC3_FASLG_SIRT1_UVRAG DRAM_FAS_LC3_BHLHE41_FASLG_UVRAG
DRAM_FAS_FRAP1_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_LAMP2
DIABLO_FAS_LC3_FASLG_SESN3 AKT1_BNIP3_DRAM_FAS_LC3_FASLG
FAS_LC3_BECN1_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG
ATG3_FAS_LC3_MMP9_FASLG DRAM_FAS_LC3_FASLG_SESN3_SIRT1
BNIP3_FAS_LC3_FASLG_SIRT1 ATG3_DIABLO_FAS_LC3_MMP9_FASLG
BNIP3_FAS_FRAP1_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN3_STAT3
DIABLO_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_BECN1_FASLG_SESN2
DIABLO_FAS_LC3_FASLG_NAMPT BNIP3_FAS_LC3_FASLG_SESN2_SIRT1
FAS_LC3_MMP9_FASLG_RPS19BP1 DIABLO_DRAM_FAS_LC3_MMP9_FASLG
BNIP3_FAS_LC3_BECN1_FASLG BNIP3_FAS_LC3_BECN1_FASLG_SESN3
E2F1_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN2_UVRAG
FAS_LC3_MMP9_FASLG_UVRAG DRAM_FAS_LC3_FASLG_LAMP2_UVRAG
ATG3_DIABLO_FAS_LC3_FASLG ATG3_FAS_FRAP1_LC3_MMP9_FASLG
DIABLO_FAS_LC3_BHLHE41_FASLG DRAM_FAS_LC3_BECN1_FASLG_SESN3
FAS_LC3_ID2_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_BECN1_FASLG
DIABLO_FAS_LC3_FASLG_LAMP2 ATG3_DRAM_FAS_LC3_MMP9_FASLG
DRAM_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_CDH1_FASLG
DRAM_FAS_LAMP1_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN2_UVRAG
ATG3_FAS_FRAP1_LC3_FASLG BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG
FAS_LC3_FASLG_STAT3_UVRAG ATG5_DRAM_FAS_LC3_FASLG_SESN3
AKT1_BNIP3_FAS_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN3_STAT3
FAS_LC3_FASLG_SESN3_UVRAG BNIP3_FAS_LC3_FASLG_SESN2_STAT3
ATG3_DRAM_FAS_LC3_FASLG BNIP3_DIABLO_FAS_LC3_MMP9_FASLG
AKT1_DRAM_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_SESN2
FAS_LC3_FASLG_SESN2_UVRAG ATG5_FAS_LC3_MMP9_FASLG_UVRAG
FAS_LC3_BHLHE41_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_BHLHE41_FASLG
DRAM_FAS_LC3_FASLG_NAMPT DIABLO_DRAM_FAS_LC3_FASLG_STAT3
FAS_LC3_FASLG_LAMP2_UVRAG ATG3_DIABLO_FAS_LC3_FASLG_SESN3
ATG7_BNIP3_FAS_LC3_FASLG DRAM_FAS_LC3_TCF3_FASLG_UVRAG
AKT1_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1
E2F1_FAS_LC3_ID2_FASLG ATG5_DRAM_FAS_LC3_FASLG_STAT3
DRAM_FAS_LC3_CDH1_FASLG ATG7_DRAM_FAS_LC3_MMP9_FASLG
PTEN_CDH1_ID2_MMP9_TCF3 LC3_CDH1_ID2_MMP9_TCF3_FASLG
七种的组合八种的组合
ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3ATG3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN3 ATG3_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1 ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_FASLG_SESN3_SIRT1 ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN3BNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3 ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SIRT1 ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAGBNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3_SIRT1ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN3 ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAGATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_SESN2BNIP3_DRAM_FAS_LC3_FASLG_SESN3_STAT3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_SESN2ATG3_FAS_LC3_ID2_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_STAT3ATG3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN3ATG5_DRAM_FAS_LC3_MMP9_FASLG_UVRAG ATG3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2 ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAGATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2 ATG3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN3 ATG3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3ATG3_FAS_LC3_FASLG_SESN2_SESN3_SIRT1 AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2ATG3_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2 BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SIRT1BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN3 ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_FAS_LC3_BECN1_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2ATG7_BNIP3_DRAM_FAS_LC3_MMP9_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_STAT3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_STAT3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAGBNIP3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_STAT3ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN3BNIP3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 BNIP3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN3 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN3 ATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_BECN1_FASLGBNIP3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG BNIP3_CSE1L_DRAM_FAS_LC3_MMP9_FASLG_SESN3ATG3_FAS_LC3_FASLG_LAMP2_SESN2_SESN3 ATG3_DRAM_FAS_LC3_ULK1_MMP9_FASLG_SESN3BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3BNIP3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN3 ATG3_FAS_LC3_ULK1_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAGBNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3_SIRT1FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG ATG3_FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG
。
15.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测C组的存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表14]
一种两种的组合二种的组合四种的组合
CSE1L ID2_CIAP2 ID2_CIAP2_SESN2 AIFM1_ID2_CIAP2_SESN2
CIAP2 CASP3_CIAP2 ID2_CASP3_CIAP2 PTEN_ID2_CIAP2_SESN2
TCF3 ID2_TCF3 ULK1_ID2_HMGB2 DIABLO_ID2_CASP3_CIAP2
CDH2 DIABLO_CDH2 ULK1_ID2_HMGB1 DRAM_FRAP1_CIAP2_TP63
FASLG CSE1L_CDH2 DIABLO_ID2_CASP3 BAX_ID2_CIAP2_SESN2
BECN1 CSE1L_TCF3 ULK1_ID2_AGER ID2_CIAP2_SESN2_VEGF
CASP3 CSE1L_CASP3 ID2_CIAP2_RPS19BP1 DRAM_ID2_CIAP2_SESN2
CDH1 CSE1L_RPS19BP1 CASP8_ULK1_ID2 ID2_CIAP2_RPS19BP1_SESN2
CDH2_CIAP2 ID2_TCF3_CIAP2 CBS_ID2_CIAP2_SESN2
ULK1_ID2 FRAP1_ID2_CIAP2 ATG3_ID2_CIAP2_SESN2
CSE1L_ID2 AIFM1_CDH1_CIAP2 NNMT_ID2_CIAP2_SESN2
CDH1_CIAP2 PTEN_CDH1_CIAP2 DIABLO_ID2_CIAP2_SESN2
CSE1L_FASLG ULK1_ID2_CIAP2 PRKAA1_ID2_CIAP2_SESN2
NNMT_CIAP2 DIABLO_ID2_CDH2 FRAP1_ID2_CIAP2_SESN2
CSE1L_MMP9 CDH1_CIAP2_VEGF DIABLO_DRAM_ID2_CASP3
CSE1L_CDH1 CDH1_CCNG2_CIAP2 XIAP_ID2_CIAP2_SESN2
CIAP2_RPS19BP1 BAX_CDH1_CIAP2 ID2_CIAP2_RAGE_SESN2
ID2_CDH2 ATG3_ID2_TCF3 DRAM_CIAP2_SESN2_TP63
CDH2_RPS19BP1 ULK1_ID2_MMP2 BNIP3_ID2_CIAP2_SESN2
CSE1L_STAT3 CBS_ULK1_ID2 BCL2L1_ID2_CIAP2_SESN2
DIABLO_CASP3 DIABLO_ID2_CIAP2 AIFM1_DIABLO_CDH1_CIAP2
CDH1_TCF3 LC3_ID2_CIAP2 ID2_CCNG2_CIAP2_SESN2
CSE1L_SIRT1 PTEN_ULK1_ID2 LC3_ID2_CIAP2_SESN2
CIAP2_SESN2 BAX_ULK1_ID2 ID2_CASP3_CIAP2_RPS19BP1
AIFM1_CIAP2 DIABLO_PTEN_CDH1 AIFM1_CDH1_CIAP2_SESN2
DIABLO_KIAA1967 CDH1_CASP3_CIAP2 ATG3_ID2_TCF3_RPS19BP1
CSE1L_KIAA1967 ULK1_ID2_CDH2 DIABLO_FRAP1_ID2_CDH2
AKT1_CSE1L CDH1_CIAP2_RAGE E2F1_ID2_CIAP2_SESN2
CSE1L_SESN2 ID2_CDH2_CIAP2 ID2_CASP3_CIAP2_SESN2
FRAP1_CDH2 NNMT_ID2_CIAP2 DRAM_ID2_CIAP2_RPS19BP1
FRAP1_CIAP2 XIAP_CIAP2_SESN2 ID2_CIAP2_HMGB1_SESN2
TCF3_FASLG CSE1L_ID2_CASP3 PTEN_ID2_CASP3_CIAP2
FASLG_SESN2 CSE1L_FRAP1_CDH2 ATG3_ID2_MMP9_TCF3
CSE1L_DIABLO BCL2_ID2_SESN2 LAMP1_ID2_CIAP2_SESN2
CSE1L_SATB1 AIFM1_ULK1_ID2 AIFM1_ID2_CASP3_CIAP2
MMP9_TCF3 ULK1_ID2_RAGE ATG5_ID2_CIAP2_SESN2
ATG12_CSE1L DIABLO_CDH1_CCNG2 DIABLO_PTEN_CDH1_CIAP2
ATG7_CSE1L BAX_DIABLO_CDH1 LAMP1_ID2_CASP3_CIAP2
CSE1L_BECN1 CSE1L_ID2_CDH2 ID2_CIAP2_HMGB2_SESN2
XIAP_CIAP2 AIFM1_CIAP2_SESN2 BCL2L1_CSE1L_ID2_SESN2
CSE1L_FAS NNMT_CDH1_CIAP2 TKT_ID2_CIAP2_SESN2
TCF3_RPS19BP1 CBS_ID2_CIAP2 DIABLO_XIAP_ID2_SESN2
XIAP_SESN2 DIABLO_CDH1_VEGF FRAP1_LC3_ID2_CIAP2
CIAP2_KIAA1967 ID2_MMP9_TCF3 ATG7_ID2_CIAP2_SESN2
TKT_CIAP2 AIFM1_DIABLO_CDH1 ID2_AGER_CIAP2_SESN2
PRKAA1_CIAP2 PRKAA1_CIAP2_SESN2 CSE1L_ID2_CASP3_CIAP2
CDH2_FASLG CDH1_ID2_CIAP2 DRAM_CASP3_CIAP2_TP63
CSE1L_FRAP1 CSE1L_CASP3_CIAP2 PTEN_CDH1_ID2_CIAP2
CSE1L_CIAP2 ULK1_ID2_VEGF CDH1_ID2_CIAP2_RPS19BP1
CSE1L_ULK1 ID2_CIAP2_HMGB1 ATG3_ULK1_ID2_HMGB1
PTEN_CIAP2 BCL2L1_CDH1_CIAP2 FRAP1_ID2_CIAP2_RPS19BP1
BCL2L1_CIAP2 ID2_CIAP2_MMP2 DIABLO_PTEN_ID2_CASP3
CIAP2_VEGF CSE1L_ID2_CIAP2 ID2_CIAP2_SESN2_TP63
ATG3_TCF3 BCL2L1_CSE1L_CDH1 ID2_TCF3_CIAP2_SESN2
AKT1_TCF3 CSE1L_CDH1_CASP3 DIABLO_CDH1_CIAP2_VEGF
CSE1L_LC3 CSE1L_XIAP_SESN2 ATG3_ULK1_ID2_AGER
TKT_CDH2 PRKAA1_CDH1_CIAP2 ID2_CIAP2_MMP2_SESN2
CDH1_ID2_MMP9_TCF3
五种的组合六种的组合
DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_TKT_CIAP2_TP63
AIFM1_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_TKT_CIAP2_SESN2_TP63
DRAM_FRAP1_CDH1_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_CIAP2_TP63
ATG12_DRAM_FRAP1_CIAP2_TP63 AIFM1_DRAM_ID2_CIAP2_SESN2_TP63
DRAM_FRAP1_XIAP_CIAP2_TP63 DRAM_TKT_ID2_CIAP2_SESN2_TP63
DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG3_DRAM_CIAP2_SESN2_TP63
AIFM1_CDH1_ID2_CIAP2_SESN2 DRAM_FRAP1_TKT_CDH1_CIAP2_TP63
AIFM1_DRAM_FRAP1_CIAP2_TP63 ATG3_DRAM_ID2_CIAP2_SESN2_TP63
DRAM_FRAP1_TKT_CIAP2_TP63 DRAM_PTEN_ID2_CIAP2_SESN2_TP63
PTEN_CDH1_ID2_CIAP2_SESN2 DRAM_FRAP1_TKT_XIAP_CIAP2_TP63
BAX_CDH1_ID2_CIAP2_SESN2 DRAM_E2F1_FRAP1_CDH1_CIAP2_TP63
DRAM_FRAP1_ID2_CIAP2_TP63 ATG3_DRAM_FRAP1_CDH1_CIAP2_TP63
DRAM_TKT_CASP3_CIAP2_TP63 ATG7_DRAM_ID2_CIAP2_SESN2_TP63
CDH1_ID2_CCNG2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_CDH1_CIAP2_TP63
AIFM1_PTEN_ID2_CIAP2_SESN2 ATG5_DRAM_ID2_CIAP2_SESN2_TP63
DIABLO_FRAP1_CDH1_ID2_CIAP2 AIFM1_DIABLO_CDH1_ID2_CIAP2_SESN2
AIFM1_CBS_ID2_CIAP2_SESN2 AIFM1_BNIP3_DRAM_CIAP2_SESN2_TP63
AIFM1_LAMP1_ID2_CIAP2_SESN2 BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63
DRAM_ID2_CASP3_CIAP2_TP63 DRAM_NNMT_ID2_CIAP2_SESN2_TP63
DIABLO_PTEN_CDH1_ID2_CIAP2 CASP8_DRAM_ID2_CIAP2_SESN2_TP63
CDH1_ID2_CIAP2_SESN2_VEGF DRAM_ID2_BHLHE41_CIAP2_SESN2_TP63
DIABLO_CDH1_ID2_CASP3_CIAP2 DRAM_FRAP1_CDH1_CIAP2_RPS19BP1_TP63
AIFM1_ATG3_ID2_CIAP2_SESN2 DRAM_LAMP1_ID2_CIAP2_SESN2_TP63
AIFM1_BNIP3_ID2_CIAP2_SESN2 DRAM_FRAP1_CDH1_ID2_CIAP2_TP63
AIFM1_DIABLO_CDH1_ID2_CIAP2 BNIP3_DRAM_ID2_CIAP2_SESN2_TP63
ATG3_DRAM_ID2_CIAP2_SESN2 DRAM_ID2_MMP9_CIAP2_SESN2_TP63
AIFM1_BAX_ID2_CIAP2_SESN2 AKT1_DRAM_ID2_CIAP2_SESN2_TP63
DRAM_E2F1_CASP3_CIAP2_TP63 DRAM_ID2_CIAP2_RAGE_SESN2_TP63
AIFM1_ID2_CIAP2_HMGB2_SESN2 ATG12_DRAM_FRAP1_XIAP_CIAP2_TP63
AIFM1_ID2_MMP9_CIAP2_SESN2 DRAM_PRKAA1_ID2_CIAP2_SESN2_TP63
DIABLO_CDH1_ID2_CIAP2_VEGF DRAM_XIAP_ID2_CIAP2_SESN2_TP63
DIABLO_DRAM_XIAP_ID2_SESN2 AIFM1_DRAM_PTEN_CIAP2_SESN2_TP63
AIFM1_ATG5_ID2_CIAP2_SESN2 ATG3_DRAM_FRAP1_CASP3_CIAP2_TP63
AIFM1_ID2_CIAP2_HMGB1_SESN2 CASP8_DRAM_FRAP1_CDH1_CIAP2_TP63
BAX_DIABLO_CDH1_ID2_CIAP2 AIFM1_ATG5_DRAM_CIAP2_SESN2_TP63
DRAM_FRAP1_NNMT_CIAP2_TP63 AIFM1_CASP8_DRAM_CIAP2_SESN2_TP63
FRAP1_CDH1_ID2_CIAP2_RPS19BP1 BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63
DRAM_XIAP_CIAP2_SESN2_TP63 CBS_DRAM_ID2_CIAP2_SESN2_TP63
AIFM1_DIABLO_ID2_CIAP2_SESN2 DRAM_FRAP1_NNMT_TKT_CIAP2_TP63
AIFM1_DRAM_ID2_CIAP2_SESN2 AIFM1_AKT1_DRAM_CIAP2_SESN2_TP63
AIFM1_ID2_CIAP2_SESN2_VEGF DRAM_FRAP1_PTEN_CDH1_CIAP2_TP63
AIFM1_TKT_ID2_CIAP2_SESN2 DIABLO_PTEN_CDH1_ID2_CIAP2_SESN2
ATG3_ID2_MMP9_TCF3_RPS19BP1 DRAM_ID2_CIAP2_SESN2_TP63_VEGF
ATG5_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_XIAP_CIAP2_SESN2_TP63
CBS_FRAP1_ID2_CIAP2_SESN2 BNIP3_DRAM_FRAP1_CDH1_CIAP2_TP63
AIFM1_DIABLO_ID2_CASP3_CIAP2 AIFM1_ATG7_DRAM_CIAP2_SESN2_TP63
AIFM1_NNMT_ID2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_NNMT_CIAP2_TP63
ATG3_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_MMP9_CIAP2_SESN2_TP63
ATG3_FRAP1_ID2_CIAP2_SESN2 AIFM1_DRAM_PRKAA1_CIAP2_SESN2_TP63
BAX_DIABLO_DRAM_ID2_CASP3 AIFM1_DRAM_CIAP2_RAGE_SESN2_TP63
LAMP1_PTEN_ID2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_XIAP_CIAP2_TP63
CDH1_ID2_CIAP2_RAGE_SESN2 AIFM1_DRAM_NNMT_CIAP2_SESN2_TP63
CBS_DIABLO_ID2_CIAP2_SESN2 DRAM_FRAP1_CDH1_CIAP2_TP63_VEGF
DIABLO_CDH1_ID2_CCNG2_CIAP2 AIFM1_DRAM_LAMP1_CIAP2_SESN2_TP63
DIABLO_LAMP1_ID2_CASP3_CIAP2 DIABLO_DRAM_FRAP1_XIAP_CASP3_HMGB2
AIFM1_DRAM_CASP3_CIAP2_TP63 DRAM_TKT_XIAP_CIAP2_SESN2_TP63
BCL2L1_DRAM_FRAP1_CIAP2_TP63 AIFM1_BCL2L1_DRAM_CIAP2_SESN2_TP63
CDH1_ID2_MMP9_TCF3_CIAP2 BAX_CDH1_ID2_MMP9_TCF3_CIAP2
七种的组合八种的组合
AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGFATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_PTEN_TKT_XIAP_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF AIFM1_ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_SATB1_TP63ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 AIFM1_AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63 ATG12_BCL2L1_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63 AIFM1_ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PTEN_MMP9_CIAP2_TP63AIFM1_BCL2L1_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_E2F1_FRAP1_TKT_MMP9_CIAP2_TP63AIFM1_ATG12_DRAM_FRAP1_PTEN_CIAP2_TP63 ATG12_BCL2L1_CBS_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63_VEGFAIFM1_DRAM_PTEN_ID2_CIAP2_SESN2_TP63 ATG12_DIABLO_DRAM_FRAP1_TKT_CDH1_CIAP2_TP63AIFM1_DRAM_TKT_MMP9_CIAP2_SESN2_TP63 AIFM1_ATG3_DRAM_ID2_MMP9_CIAP2_SESN2_TP63ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63 ATG12_CBS_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_LAMP1_TKT_XIAP_CIAP2_TP63ATG12_DRAM_E2F1_FRAP1_TKT_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_BHLHE41_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_HMGB1_TP63AIFM1_ATG12_DRAM_FRAP1_MMP9_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63AIFM1_ATG3_DRAM_ID2_CIAP2_SESN2_TP63 AIFM1_DRAM_PTEN_ID2_MMP9_CIAP2_SESN2_TP63AIFM1_ATG3_DRAM_MMP9_CIAP2_SESN2_TP63 ATG12_ATG7_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_CIAP2_HMGB1_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63_VEGFAIFM1_ATG12_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_BNIP3_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63AIFM1_DRAM_ID2_MMP9_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63AIFM1_DRAM_LAMP1_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63_VEGFDRAM_FRAP1_TKT_CASP3_CIAP2_HMGB2_TP63 ATG12_DRAM_FRAP1_LAMP1_PTEN_TKT_CIAP2_TP63AIFM1_AKT1_ATG12_DRAM_FRAP1_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63AIFM1_DRAM_PRKAA1_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_DRAM_TKT_CIAP2_RAGE_SESN2_TP63 AIFM1_ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_TP63AIFM1_DRAM_TKT_ID2_CIAP2_SESN2_TP63 ATG12_BCL2L1_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_T T_CIAP2_SATB1_TP63 ATG12_CBS_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63AIFM1_AKT1_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_LAMP1_PRKAA1_TKT_CIAP2_TP63A M1_ATG12_DRAM_FRAP1_CIAP2_TP63_VEGF ATG12_DR M_FRAP1_LAMP1_TKT_CIAP2_RAGE_TP63AIFM1_ATG3_DRAM_NNMT_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63AIFM1_BAX_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_BCL2L1_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_DRAM_NNMT_ID2_CIAP2_SESN2_TP63 ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63_VEGFDRAM_FRAP1_NNMT_TKT_XIAP_CIAP2_TP63 AIFM1_ TG3_DRAM_NNMT_ID2_CIAP2_SESN2_TP63BC DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_DRAM_NNMT_PTEN_ID2_CIAP2_SESN2_TP63AIFM1_ATG12_ATG3_DRAM_FRAP1_CIAP2_TP63 ATG12_CBS_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63AIFM1_ATG7_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_PTEN_TKT_MMP9_CIAP2_TP63AIFM1_DRAM_TKT_CIAP2_SESN2_TP63_VEGF AIFM1_ATG12_ATG3_DRAM_FRAP1_MMP9_CIAP2_TP63ATG12_ATG3_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_CASP8_DRAM_TKT_CIAP2_SESN2_TP63AIFM1_AKT1_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_ATG7_CBS_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_ATG12_ATG7_DRAM_FRAP1_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63AIFM1_ATG3_BCL2L1_DRAM_CIAP2_SESN2_TP63 AIFM1_ATG12_DRAM_PTEN_TKT_CIAP2_SESN2_TP63AIFM1_ATG7_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_BCL2L1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63AIFM1_BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_E2F1_FRAP1_NNMT_TKT_CIAP2_TP63AIFM1_CBS_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63_VEGFAIFM1_DRAM_PTEN_TKT_CIAP2_SESN2_TP63 ATG12_BNIP3_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63AIFM1_DRAM_TKT_BHLHE41_CIAP2_SESN2_TP63 ATG12_CBS_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_TP63 ATG12_DIABLO_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63BCL2L1_DRAM_TKT_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_PRKAA1_TKT_XIAP_CIAP2_TP63BAX_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_RAGE_TP63CBS_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3 ATG3_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3_AGER
16.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测C组的无病存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表15]
一种两种的组合三种的组合四种的组合
FASLG FAS_FASLG FAS_LC3_FASLG DIABLO_FAS_LC3_FASLG
CIAP2 LC3_FASLG DIABLO_FAS_FASLG FAS_LC3_FASLG_UVRAG
FAS E2F1_FASLG E2F1_LC3_FASLG E2F1_FAS_LC3_FASLG
CSE1L CIAP2_FASLG FAS_FASLG_RPS19BP1 BNIP3_FAS_LC3_FASLG
TCF3 DIABLO_FASLG E2F1_FAS_FASLG DRAM_FAS_LC3_FASLG
FASLG_RPS19BP1 FAS_FASLG_UVRAG ATG7_FAS_LC3_FASLG
FASLG_SESN2 DIABLO_LC3_FASLG FAS_LAMP1_LC3_FASLG
CASP3_FASLG ATG7_FAS_FASLG FAS_FRAP1_LC3_FASLG
FASLG_UVRAG FAS_FASLG_SESN2 ATG3_FAS_LC3_FASLG
FRAP1_FASLG LC3_FASLG_SESN2 FAS_LC3_FASLG_RPS19BP1
PTEN_FASLG FAS_LAMP1_FASLG FAS_LC3_FASLG_SESN3
FASLG_HMGB1 ATG3_FAS_FASLG FAS_LC3_FASLG_SESN2
ATG3_FAS C IAP2_FASLG_SESN3 ATG5_FAS_LC3_FASLG
CASP3_CIAP2 FAS_FRAP1_FASLG FAS_LC3_FASLG_STAT3
TCF3_FASLG FRAP1_LC3_FASLG FAS_LC3_FASLG_SIRT1
ATG7_FASLG BNIP3_LC3_FASLG AKT1_FAS_LC3_FASLG
PTEN_CIAP2 FAS_FASLG_SESN3 FAS_LC3_ID2_FASLG
CDH2_FASLG BNIP3_FAS_FASLG FAS_LC3_FASLG_NAMPT
FASLG_SESN3 DIABLO_FASLG_SESN2 FAS_LC3_BECN1_FASLG
DIABLO_FAS CIAP2_FASLG_UVRAG FAS_LC3_MMP9_FASLG
FAS_LC3 LC3_FASLG_UVRAG DIABLO_FAS_FASLG_UVRAG
ULK1_FASLG LC3_CIAP2_FASLG ATG12_FAS_LC3_FASLG
CSE1L_FASLG DRAM_FAS_FASLG FAS_FASLG_RPS19BP1_UVRAG
CBS_FASLG LC3_FASLG_SESN3 DIABLO_FAS_FASLG_SESN2
FASLG_HMGB2 FAS_FASLG_STAT3 FAS_LC3_FASLG_LAMP2
FAS_UVRAG ATG7_LC3_FASLG FAS_LC3_CDH1_FASLG
LAMP1_FASLG ATG5_FAS_FASLG DIABLO_FAS_FASLG_SESN3
BNIP3_FASLG E2F1_FASLG_SESN2 FAS_LC3_TCF3_FASLG
MMP9_FASLG LC3_ID2_FASLG E2F1_LC3_ID2_FASLG
TKT_FASLG DRAM_LC3_FASLG FAS_LC3_BHLHE41_FASLG
FASLG_STAT3 FAS_TCF3_FASLG DIABLO_FAS_LAMP1_FASLG
AKT1_FASLG AKT1_FAS_FASLG DIABLO_DRAM_FAS_FASLG
FASLG_MMP2 E2F1_ULK1_FASLG FAS_FASLG_SESN2_UVRAG
DRAM_FASLG E2F1_TCF3_FASLG FAS_FASLG_RPS19BP1_SESN3
FASLG_SIRT1 LC3_FASLG_RPS19BP1 DIABLO_FAS_FRAP1_FASLG
ATG12_FASLG LC3_MMP9_FASLG DIABLO_FAS_FASLG_STAT3
CIAP2_RAGE FAS_FASLG_SIRT1 ATG7_DIABLO_FAS_FASLG
FAS_LAMP1 FAS_ULK1_FASLG CSE1L_FAS_LC3_FASLG
ATG5_FASLG FAS_FASLG_NAMPT E2F1_LC3_MMP9_FASLG
ATG3_FASLG LC3_FASLG_SIRT1 DRAM_FAS_FASLG_RPS19BP1
E2F1_FAS CASP3_CIAP2_FASLG DIABLO_FAS_FASLG_RPS19BP1
BECN1_FASLG ATG12_FAS_FASLG FAS_LC3_ULK1_FASLG
E2F1_CIAP2 FAS_BECN1_FASLG DIABLO_FAS_FASLG_SIRT1
CASP8_FASLG ATG5_LC3_FASLG DIABLO_FAS_ID2_FASLG
XIAP_CIAP2 LC3_BECN1_FASLG AKT1_DIABLO_FAS_FASLG
CDH1_FASLG LC3_FASLG_STAT3 DIABLO_FAS_FASLG_NAMPT
FASLG_NAMPT E2F1_FASLG_SESN3 ATG3_FAS_FASLG_SESN2
BNIP3_FAS AKT1_LC3_FASLG FAS_FASLG_RPS19BP1_SESN2
FASLG_LAMP2 FAS_FASLG_LAMP2 DIABLO_FAS_BECN1_FASLG
AGER_FASLG LC3_TCF3_FASLG DIABLO_FAS_CDH1_FASLG
ID2_FASLG LC3_FASLG_NAMPT ATG7_FAS_FASLG_UVRAG
AIFM1_FASLG LC3_CDH1_FASLG DIABLO_FAS_FASLG_LAMP2
FASLG_SESN1 ATG12_LC3_FASLG FAS_FRAP1_FASLG_RPS19BP1
AIFM1_CIAP2 PTEN_CDH1_CIAP2 FAS_LAMP1_FASLG_UVRAG
PRKAA1_CIAP2 LC3_FASLG_LAMP2 E2F1_FAS_LAMP1_FASLG
BCL2L1_CIAP2 DIABLO_FASLG_SESN3 ATG7_FAS_FASLG_RPS19BP1
XIAP_FASLG FAS_CDH1_FASLG E2F1_FAS_FASLG_UVRAG
CDH1_ID2_MMP9_TCF3
五种的组合六种的组合
DIABLO_FAS_LC3_ID2_FASLG BNIP3_DRAM_FAS_LC3_FASLG_SESN2
DRAM_FAS_LC3_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG
DIABLO_DRAM_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2
BNIP3_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_ID2_FASLG_UVRAG
BNIP3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_UVRAG
BNIP3_DRAM_FAS_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN2_UVRAG
BNIP3_DIABLO_FAS_LC3_FASLG DIABLO_FAS_LC3_ID2_FASLG_UVRAG
FAS_LC3_ID2_FASLG_UVRAG DIABLO_FAS_LC3_ID2_FASLG_STAT3
DIABLO_FAS_LC3_FASLG_UVRAG DIABLO_FAS_LC3_ID2_FASLG_SESN3
DIABLO_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_MMP9_FASLG_UVRAG
DIABLO_FAS_LC3_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_FASLG_SESN3
DIABLO_FAS_LC3_FASLG_SIRT1 BNIP3_FAS_LC3_ID2_FASLG_UVRAG
FAS_LC3_MMP9_FASLG_RPS19BP1 DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1
ATG5_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1
BNIP3_FAS_LC3_FASLG_SESN3 BNIP3_FAS_LC3_ID2_FASLG_SESN2
DIABLO_FAS_LC3_BECN1_FASLG BNIP3_DIABLO_FAS_LC3_ID2_FASLG
DIABLO_FAS_LC3_CDH1_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN2
ATG3_FAS_LC3_FASLG_SESN2 DIABLO_FAS_LC3_ID2_FASLG_SIRT1
D RAM_E2F1_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_UVRAG
FAS_LC3_FASLG_SESN2_UVRAG FAS_LC3_MMP9_FASLG_RPS19BP1_UVRAG
DIABLO_FAS_LC3_FASLG_LAMP2 ATG3_FAS_LC3_FASLG_SESN2_SESN3
E2F1_FAS_LC3_ID2_FASLG DRAM_FAS_LC3_FASLG_SESN2_UVRAG
D IABLO_FAS_LC3_FASLG_NAMPT DIABLO_FAS_LC3_ID2_BECN1_FASLG
DIABLO_FAS_LC3_MMP9_FASLG DRAM_FAS_LC3_FASLG_SIRT1_UVRAG
FAS_LC3_FASLG_SIRT1_UVRAG FAS_LC3_ID2_FASLG_SESN2_UVRAG
FAS_LC3_FASLG_SESN3_UVRAG DIABLO_FAS_LC3_CDH1_ID2_FASLG
FAS_LAMP1_LC3_FASLG_UVRAG FAS_LC3_ID2_MMP9_FASLG_RPS19BP1
AKT1_DIABLO_FAS_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN2_SESN3
DIABLO_FAS_FRAP1_LC3_FASLG DIABLO_FAS_LC3_ID2_FASLG_NAMPT
DIABLO_FAS_LC3_BHLHE41_FASLG DIABLO_FAS_LC3_ID2_FASLG_SESN2
FAS_LC3_FASLG_STAT3_UVRAG DIABLO_FAS_LC3_ID2_FASLG_LAMP2
DIABLO_FAS_LC3_FASLG_SESN2 BNIP3_FAS_LC3_FASLG_SESN2_SIRT1
E2F1_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN2_STAT3
BNIP3_FAS_FRAP1_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN3_UVRAG
DIABLO_FAS_LAMP1_LC3_FASLG DIABLO_DRAM_FAS_LC3_FASLG_STAT3
FAS_LC3_BECN1_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG
AKT1_FAS_LC3_FASLG_UVRAG ATG5_FAS_LC3_ID2_FASLG_UVRAG
BNIP3_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN3_UVRAG
FAS_FRAP1_LC3_FASLG_UVRAG DRAM_FAS_LC3_BECN1_FASLG_UVRAG
BNIP3_FAS_LC3_FASLG_STAT3 DIABLO_DRAM_FAS_LC3_CDH1_FASLG
FAS_LC3_CDH1_FASLG_UVRAG AKT1_DIABLO_FAS_LC3_ID2_FASLG
FAS_LC3_FASLG_LAMP2_UVRAG BNIP3_DIABLO_FAS_LC3_MMP9_FASLG
FAS_LC3_MMP9_FASLG_UVRAG DRAM_FAS_LC3_CDH1_FASLG_UVRAG
ATG7_FAS_LC3_FASLG_UVRAG DIABLO_FAS_FRAP1_LC3_ID2_FASLG
ATG7_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_STAT3
BNIP3_FAS_LC3_FASLG_SIRT1 DIABLO_DRAM_FAS_LC3_FASLG_SESN3
DRAM_FAS_LAMP1_LC3_FASLG BNIP3_DIABLO_DRAM_FAS_LC3_FASLG
ATG7_BNIP3_FAS_LC3_FASLG DIABLO_DRAM_FAS_LC3_FASLG_SIRT1
BNIP3_FAS_LAMP1_LC3_FASLG BNIP3_DRAM_FAS_FRAP1_LC3_FASLG
ATG3_FAS_LC3_MMP9_FASLG DIABLO_DRAM_FAS_LC3_BECN1_FASLG
ATG5_DIABLO_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN3
BNIP3_FAS_LC3_ID2_FASLG DIABLO_FAS_LAMP1_LC3_ID2_FASLG
ATG12_DIABLO_FAS_LC3_FASLG DRAM_FAS_LC3_FASLG_LAMP2_UVRAG
E2F1_FAS_LC3_FASLG_SESN3 ATG5_FAS_LC3_FASLG_SESN2_UVRAG
AKT1_BNIP3_FAS_LC3_FASLG FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3
FAS_LC3_FASLG_NAMPT_UVRAG FAS_LAMP1_LC3_ID2_FASLG_UVRAG
ATG12_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG
PTEN_CDH1_ID2_MMP9_TCF3 LC3_CDH1_ID2_MMP9_TCF3_FASLG
七种的组合八种的组合
ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAGBNIP3_FAS_LC3_ID2_FASLG_SESN2_UVRAG ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAGFAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_ID2_FASLG_UVRAG ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAGDRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAGDRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 ATG5_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAGATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1 ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAG ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3 ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAG ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_TCF3_FASLG_UVRAGDIABLO_DRAM_FAS_LC3_ID2_FASLG_STAT3 DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3DIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAGATG5_DRAM_FAS_LC3_ID2_FASLG_UVRAG ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1 ATG3_DIABLO_FAS_LC3_ID2_MMP9_FASLG_SESN2ATG5_FAS_LC3_ID2_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAGATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAGDIABLO_DRAM_FAS_LC3_ID2_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2DIABLO_DRAM_FAS_LC3_CDH1_ID2_FASLG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1DRAM_FAS_LC3_ID2_FASLG_SIRT1_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3DIABLO_DRAM_FAS_LC3_ID2_FASLG_SIRT1 ATG3_FAS_LC3_ID2_MMP9_TCF3_FASLG_SESN2BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3 ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3BNIP3_FAS_LC3_ID2_MMP9_FASLG_UVRAG BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN2_UVRAGDIABLO_DRAM_FAS_LC3_ID2_BECN1_FASLG ATG5_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAGDRAM_FAS_LC3_ID2_FASLG_SESN3_UVRAG BNIP3_FAS_LC3_CDH1_ID2_FASLG_SESN2_UVRAGATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2 BNIP3_FAS_LC3_ID2_FASLG_SESN2_SIRT1_UVRAGBNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3 ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3BNIP3_FAS_LC3_ID2_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_CDH1_ID2_FASLG_SESN2DIABLO_DRAM_FAS_LC3_ID2_FASLG_LAMP2 BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN3_UVRAGBNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2 AKT1_BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2ATG5_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_LAMP2_SESN2DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_UVRAG ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3DRAM_FAS_LAMP1_LC3_ID2_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2_UVRAGDIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN2 BNIP3_FAS_LC3_ID2_FASLG_LAMP2_SESN2_UVRAGATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2 BNIP3_FAS_LC3_ID2_BECN1_FASLG_SESN2_UVRAGAKT1_BNIP3_DRAM_FAS_LC3_FASLG_SESN2 BNIP3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAGDRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 BNIP3_DRAM_FAS_LC3_ID2_TCF3_FASLG_UVRAGATG3_D RAM_FAS_LC3_FASLG_SESN2_SESN3 AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAGDRAM_FAS_LC3_ID2_FASLG_STAT3_UVRAG ATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_CDH1_FASLG_UVRAG BNIP3_DRAM_FAS_LAMP1_LC3_ID2_FASLG_SESN2ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 ATG3_FAS_FRAP1_LC3_ID2_MMP9_FASLG_SESN2DRAM_FAS_LC3_ID2_BECN1_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2E2F1_LC3_CDH1_ID2_MMP9_TCF3_FASLG FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG_UVRAG。
17.如权利要求1所述的组合物或试剂盒，其中，所述核酸是引物或探针。
18.如权利要求1所述的组合物或试剂盒，其中，所述肝癌预后是对癌症肝脏切除术后的预后的预测。
19.一种用于预测肝癌预后的组合物或试剂盒，所述组合物或试剂盒包含：对选自下表所示的组的一种或至少两种基因中的每一种分别具有特异性的核酸，或对所述基因编码的蛋白有特异性的抗体：
[表2]
20.如权利要求19所述的组合物或试剂盒，其中，由基因组成的所述组还包含下表所示的基因：
[表3]
21.如权利要求19所述的组合物或试剂盒，其中，所述核酸是引物或探针。
22.如权利要求19所述的组合物或试剂盒，其中，所述预测肝癌预后是预测癌症肝脏切除术后的预后。
23.一种根据分期来预测肝癌预后的方法，所述方法包括：
(A)检测获自肝癌患者的样品中的选自由下表所示的基因组成的组的一种或至少两种基因的表达水平或表达模式中的一项或多项；和
(B)将步骤(A)的结果与对照组的测量结果进行比较，从而预测肝癌预后，
其中，所述肝癌患者属于选自A1组、A2组、B组或C组的一个或多个组；其中A1组为门静脉侵袭阴性患者组，患者处于BCLC(巴塞罗那临床肝癌)分期系统的0期或A期，具有
1个尺寸为5cm以下的肿瘤或3个以下尺寸为3cm以下的肿瘤；A2组为门静脉侵袭阴性患者组，患者具有尺寸大于5cm的肿瘤；B组为门静脉侵袭阴性患者组，患者处于BCLC分期系统中期，具有多个尺寸大于3cm的肿瘤或数量大于3的多个肿瘤；C组为门静脉侵袭阳性患者组，不论肿瘤尺寸和数量如何；
[表1]
24.如权利要求23所述的方法，其中，由基因组成的所述组是下表所示的基因组成的组：
[表2]
25.如权利要求23所述的方法，其中，由基因组成的所述组还包含下表所示的基因：
[表3]
26.如权利要求23所述的方法，所述方法用于预测A1组的复发预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表4]
一种两种的组合三种的组合四种的组合
BCL2L1 FRAP1_SESN1 FRAP1_CASP3_CDH2 ID2_NAMPT_RPS19BP1_SESN3
BECN1 FRAP1_TWIST1 ID2_CDH2_SESN3 FRAP1_LC3_CASP3_CDH2
BAX FRAP1_CASP3 FRAP1_CDH2_SESN1 FRAP1_TKT_CASP3_CDH2
CDH2 FRAP1_CCNG2 FRAP1_LC3_CASP3 BAX_FRAP1_LC3_CDH2
NAMPT BAX_FRAP1 FRAP1_LC3_TWIST1 ID2_CDH2_NAMPT_SESN3
TWIST1 FRAP1_NNMT BAX_FRAP1_LC3 CBS_ID2_CDH2_SESN3
RPS19BP1 BCL2L1_FRAP1 FRAP1_CDH2_TWIST1 FRAP1_LC3_CDH2_KIAA1967
MMP2 AIFM1_FRAP1 FRAP1_NNMT_CDH2 FRAP1_CDH2_SESN1_STAT3
SESN3 FRAP1_RAGE FRAP1_LC3_NNMT FRAP1_LC3_NNMT_CDH2
ID2 FRAP1_VEGF BAX_FRAP1_CDH2 FRAP1_LC3_CDH2_RAPTOR
AGER ID2_CDH2 FRAP1_SESN1_STAT3 ID2_CDH2_RPS19BP1_SESN3
ATG12 FRAP1_PTEN AIFM1_FRAP1_CDH2 FRAP1_LC3_CDH2_TWIST1
NAMPT_SESN3 FRAP1_LC3_VEGF FRAP1_LC3_CDH2_VEGF
BCL2_FRAP1 FRAP1_NNMT_MMP2 FRAP1_LC3_SESN1_STAT3
CDH2_SESN3 FRAP1_LC3_RAGE FRAP1_LC3_CDH2_RAGE
FRAP1_RAPTOR FRAP1_CCNG2_CDH2 FRAP1_LC3_NNMT_STAT3
FRAP1_KIAA1967 BCL2L1_FRAP1_CDH2 ID2_CDH2_MMP2_SESN3
FRAP1_XIAP FRAP1_CDH2_VEGF FRAP1_LC3_CASP3_STAT3
BECN1_SESN3 FRAP1_LC3_CCNG2 AIFM1_FRAP1_LC3_CDH2
HMGB1_TWIST1 FRAP1_CASP3_MMP2 BCL2L1_FRAP1_LC3_CDH2
ID2_NAMPT BCL2L1_FRAP1_LC3 FRAP1_LC3_PTEN_CDH2
FRAP1_PRKAA1 FRAP1_LC3_SESN1 BAX_FRAP1_LC3_BECN1
ID2_RPS19BP1 FRAP1_CDH2_KIAA1967 BAX_FRAP1_LC3_RPS19BP1
BAX_LC3 AIFM1_FRAP1_LC3 FRAP1_CASP3_CDH2_STAT3
FRAP1_TP63 FRAP1_LC3_RAPTOR LC3_HMGB1_STAT3_TWIST1
ATG12_SESN3 FRAP1_CDH2_RAGE BAX_FRAP1_TKT_CDH2
BAX_TWIST1 BAX_FRAP1_MMP2 FRAP1_LC3_CCNG2_CDH2
RPS19BP1_SESN3 FRAP1_LC3_PTEN FRAP1_TKT_CDH2_SESN1
BAX_MMP2 FRAP1_TKT_CASP3 FRAP1_LC3_HMGB1_TWIST1
SESN1_STAT3 FRAP1_PTEN_CDH2 FRAP1_NNMT_TKT_CDH2
LC3_TWIST1 FRAP1_TKT_TWIST1 BAX_FRAP1_LC3_MMP2
MMP2_NAMPT FRAP1_LC3_KIAA1967 FRAP1_LC3_CCNG2_STAT3
ID2_BECN1 BAX_FRAP1_TKT FRAP1_LC3_STAT3_TWIST1
BCL2L1_LC3 BCL2_FRAP1_CDH2 FRAP1_TKT_CDH2_TWIST1
MMP2_RPS19BP1 FRAP1_HMGB1_TWIST1 FRAP1_LC3_NNMT_MMP2
ATG7_BCL2L1 FRAP1_RPS19BP1_TWIST1 BAX_FRAP1_TKT_MMP2
ID2_TWIST1 FRAP1_CDH2_RAPTOR FRAP1_NNMT_CDH2_MMP2
CDH2_HMGB1 FRAP1_TKT_SESN1 FRAP1_LC3_CDH2_SESN1
CDH2_MMP2 FRAP1_RPS19BP1_SESN1 BAX_FRAP1_LC3_TKT
ATG7_TWIST1 BAX_FRAP1_BECN1 FAS_FRAP1_CDH2_SESN1
BAX_SESN3 ID2_NAMPT_SESN3 BAX_FAS_FRAP1_LC3
FASLG_NAMPT FRAP1_CCNG2_STAT3 FRAP1_CASP3_CDH2_MMP2
ATG7_BAX BCL2L1_FRAP1_MMP2 ID2_FASLG_NAMPT_SESN3
TKT_NAMPT BCL2_FRAP1_LC3 FRAP1_ID2_CDH2_TWIST1
STAT3_TWIST1 FASLG_NAMPT_SESN3 FRAP1_CDH2_HMGB1_TWIST1
BCL2L1_MMP2 AIFM1_FRAP1_MMP2 BAX_FRAP1_BECN1_CDH2
LC3_KIAA1967 FRAP1_CCNG2_RPS19BP1 DRAM_ID2_CDH2_SESN3
BAX_BECN1 BAX_FRAP1_RPS19BP1 FRAP1_LC3_RPS19BP1_TWIST1
ATG12_ID2 FAS_FRAP1_SESN1 AIFM1_FRAP1_TKT_CDH2
BECN1_MMP2 BCL2L1_FRAP1_TKT FRAP1_TKT_CCNG2_CDH2
AKT1_BAX FRAP1_NNMT_STAT3 BCL2L1_FRAP1_TKT_CDH2
LC3_RAPTOR FRAP1_MMP2_SESN1 DIABLO_ID2_CDH2_SESN3
BAX_RPS19BP1 FRAP1_ID2_TWIST1 BCL2_FRAP1_LC3_CDH2
BAX_TKT FRAP1_CASP3_STAT3 FRAP1_LC3_CASP3_FASLG
BAX_SATB1 FRAP1_TKT_CCNG2 FRAP1_CDH2_RPS19BP1_SESN1
LC3_NAMPT FRAP1_MMP2_VEGF FRAP1_LC3_CASP3_MMP2
KIAA1967_MMP2 FRAP1_MMP2_RAPTOR ID2_CDH2_HMGB2_SESN3
CDH1_ID2_MMP9_TCF3
五种的组合六种的组合
FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_LC3_BECN1_CASP3_CDH2_STAT3
ID2_MMP2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_NNMT_BECN1_CDH2_STAT3
FRAP1_LC3_CDH2_SESN1_STAT3 FRAP1_LC3_TKT_CASP3_CDH2_STAT3
ID2_CDH2_MMP2_RPS19BP1_SESN3 ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3
FRAP1_LC3_NNMT_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_SESN1_STAT3
BAX_FRAP1_LC3_BECN1_CDH2 ID2_CDH2_FASLG_NAMPT_RPS19BP1_SESN3
ID2_FASLG_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_CASP3_CDH2_HMGB1_STAT3
BAX_FRAP1_LC3_TKT_CDH2 FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3
FRAP1_LC3_BECN1_CDH2_RAPTOR FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3
FRAP1_LC3_CDH2_STAT3_TWIST1 FRAP1_LC3_CDH2_HMGB1_STAT3_TWIST1
FRAP1_LC3_CCNG2_CDH2_STAT3 ID2_HMGB2_MMP2_NAMPT_RPS19BP1_SESN3
ID2_CDH2_FASLG_NAMPT_SESN3 AIFM1_FRAP1_LC3_BECN1_CDH2_STAT3
LC3_CDH2_HMGB1_STAT3_TWIST1 ID2_MMP2_NAMPT_RPS19BP1_SESN3_STAT3
ID2_CDH2_HMGB1_RPS19BP1_SESN3 ID2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3
ID2_CDH2_MMP2_NAMPT_SESN3 AKT1_FAS_BECN1_CDH2_STAT3_TP63
FRAP1_LC3_BECN1_CDH2_KIAA1967 FRAP1_LC3_CCNG2_CDH2_RPS19BP1_STAT3
BAX_FRAP1_LC3_CDH2_RPS19BP1 AKT1_ATG12_BECN1_CDH2_STAT3_TP63
ID2_HMGB2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3
ID2_NAMPT_RPS19BP1_SESN3_STAT3 CSE1L_FRAP1_LC3_CASP3_CDH2_STAT3
FRAP1_LC3_CDH2_HMGB1_TWIST1 FRAP1_LC3_BECN1_CDH2_RAGE_STAT3
FRAP1_TKT_CDH2_SESN1_STAT3 FAS_FRAP1_LC3_NNMT_CDH2_STAT3
CSE1L_ID2_CDH2_RPS19BP1_SESN3 ID2_HMGB1_MMP2_NAMPT_RPS19BP1_SESN3
FRAP1_LC3_TKT_CASP3_CDH2 FRAP1_LC3_TKT_CDH2_SESN1_STAT3
BAX_FAS_FRAP1_LC3_CDH2 FRAP1_LC3_NNMT_CDH2_MMP2_STAT3
FAS_FRAP1_LC3_CDH2_RAPTOR FRAP1_LC3_NNMT_TKT_CDH2_STAT3
LC3_CASP3_CDH2_HMGB1_STAT3 BAX_FRAP1_LC3_BECN1_CDH2_STAT3
FAS_FRAP1_LC3_CDH2_KIAA1967 FRAP1_LC3_CASP3_CDH2_SIRT1_STAT3
AIFM1_FRAP1_LC3_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR_RPS19BP1
FRAP1_LC3_BECN1_CASP3_STAT3 CBS_FRAP1_LC3_CASP3_CDH2_STAT3
FRAP1_BECN1_CASP3_CDH2_STAT3 FAS_FRAP1_LC3_CASP3_CDH2_STAT3
ID2_CDH2_NAMPT_SESN3_STAT3 AKT1_ATG12_FAS_CDH2_STAT3_TP63
LC3_ID2_NAMPT_RPS19BP1_SESN3 LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1
FRAP1_LC3_NNMT_MMP2_STAT3 FRAP1_LC3_BECN1_CDH2_STAT3_TWIST1
BAX_FRAP1_LC3_CASP3_CDH2 FRAP1_LC3_CASP3_CDH2_MMP2_STAT3
FRAP1_TKT_CASP3_CDH2_STAT3 ID2_MMP9_MMP2_NAMPT_RPS19BP1_SESN3
LC3_HMGB1_RPS19BP1_STAT3_TWIST1 CSE1L_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_CDH2_RPS19BP1_SESN1_STAT3 FRAP1_LC3_BECN1_CDH2_STAT3_VEGF
CBS_FRAP1_LC3_CASP3_CDH2 BAX_FRAP1_LC3_TKT_BECN1_CDH2
FRAP1_LAMP1_TKT_CASP3_CDH2 FRAP1_LC3_NNMT_CASP3_CDH2_STAT3
ID2_CDH2_HMGB1_NAMPT_SESN3 FRAP1_TKT_BECN1_CASP3_CDH2_STAT3
ID2_HMGB1_NAMPT_RPS19BP1_SESN3 ID2_FASLG_NAMPT_RPS19BP1_SESN3_STAT3
AKT1_ID2_NAMPT_RPS19BP1_SESN3 FAS_FRAP1_LC3_CDH2_KIAA1967_RPS19BP1
FRAP1_LC3_TKT_CDH2_KIAA1967 FRAP1_LC3_BECN1_CDH2_SESN1_STAT3
FRAP1_LC3_CASP3_CDH2_HMGB1 ID2_CDH2_FASLG_NAMPT_SESN3_STAT3
ATG7_FRAP1_LC3_CASP3_CDH2 FRAP1_LC3_TKT_CDH2_STAT3_TWIST1
BAX_FRAP1_LC3_TKT_MMP2 ATG5_FRAP1_LC3_CASP3_CDH2_STAT3
FRAP1_LC3_CDH2_RAPTOR_RPS19BP1 ID2_CDH2_MMP2_RPS19BP1_SESN3_STAT3
FRAP1_LC3_RPS19BP1_SESN1_STAT3 FAS_LC3_CDH2_HMGB1_STAT3_TWIST1
BAX_FRAP1_LC3_CDH2_MMP2 AIFM1_FRAP1_LC3_TKT_CDH2_STAT3
ID2_TCF3_CDH2_RPS19BP1_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_FASLG
FRAP1_TKT_CASP3_CDH2_FASLG DRAM_ID2_MMP2_NAMPT_RPS19BP1_SESN3
FAS_FRAP1_CDH2_SESN1_STAT3 FRAP1_LC3_CASP3_CDH2_NAMPT_STAT3
CBS_ID2_NAMPT_RPS19BP1_SESN3 FAS_FRAP1_LC3_CCNG2_CDH2_STAT3
FRAP1_LC3_CDH2_KIAA1967_MMP2 BAX_FAS_FRAP1_LC3_CDH2_RPS19BP1
FAS_FRAP1_LC3_CASP3_CDH2 BNIP3_FRAP1_LC3_CASP3_CDH2_STAT3
BAX_CBS_FRAP1_LC3_CDH2 FRAP1_LC3_CDH2_RPS19BP1_STAT3_TWIST1
FRAP1_LC3_TKT_CDH2_RAPTOR FRAP1_LC3_MMP9_CASP3_CDH2_STAT3
CDH1_ID2_MMP9_TCF3_RPS19BP1 CDH1_ID2_MMP9_TCF3_RPS19BP1_SESN3
七种的组合八种的组合
AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63ID2_CDH2_FASLG_NAMPT_RPS19BP1_SESN3_STAT3 AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63FRAP1_LC3_NNMT_TKT_BECN1_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63AKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 FAS_FRAP1_LC3_BECN1_CASP3_CDH2_RPS19BP1_STAT3FAS_FRAP1_LC3_CCNG2_CDH2_RPS19BP1_STAT3 AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63FRAP1_LC3_BECN1_CASP3_CDH2_HMGB1_STAT3 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_FASLG_STAT3ID2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3_STAT3 CSE1L_FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3FRAP1_LC3_NNMT_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63CBS_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 FAS_FRAP1_LC3_NNMT_BECN1_CDH2_RPS19BP1_STAT3FRAP1_LC3_BECN1_CASP3_CDH2_SIRT1_STAT3 AKT1_CASP8_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63CSE1L_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 FRAP1_LC3_NNMT_TKT_BECN1_CDH2_FASLG_STAT3FRAP1_LC3_TKT_CASP3_CDH2_HMGB1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63FRAP1_LC3_TKT_CDH2_HMGB1_STAT3_TWIST1 AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63ATG5_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63CSE1L_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 ID2_CDH2_FASLG_HMGB1_HMGB2_NAMPT_RPS19BP1_SESN3FRAP1_LC3_BECN1_CASP3_CDH2_HMGB2_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_CIAP2_STAT3_TP63AKT1_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_CDH2_MMP2_RAPTOR_RPS19BP1 ID2_CDH2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3_STAT3AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63FRAP1_LC3_BECN1_CASP3_CDH2_FASLG_STAT3 AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3 AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RPS19BP1_SESN2_STAT3_TP63FAS_FRAP1_LC3_TKT_CDH2_SESN1_STAT3 AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63CBS_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 AKT1_LC3_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63FRAP1_LC3_BECN1_CDH2_HMGB1_STAT3_TWIST1 FAS_FRAP1_LC3_CASP3_CDH2_FASLG_RPS19BP1_STAT3CSE1L_FRAP1_LC3_TKT_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_CASP3_CDH2_STAT3_TP63FRAP1_LC3_NNMT_BECN1_CDH2_SIRT1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_HMGB2_STAT3_TP63AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63ID2_CDH2_FASLG_HMGB1_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_FASLG_HMGB1_STAT3ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3_STAT3 FAS_FRAP1_LC3_NNMT_CDH2_MMP2_RPS19BP1_STAT3FRAP1_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 FAS_FRAP1_LC3_BECN1_CDH2_RPS19BP1_SESN1_STAT3FAS_FRAP1_LC3_CDH2_KIAA1967_MMP2_RPS19BP1 FAS_FRAP1_LC3_TKT_CDH2_RPS19BP1_SESN1_STAT3FRAP1_LC3_BECN1_CASP3_CDH2_RPS19BP1_STAT3 AKT1_ATG12_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63FRAP1_LC3_TKT_CASP3_CDH2_FASLG_STAT3 AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63BNIP3_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63FRAP1_LC3_CASP3_CDH2_HMGB1_MMP2_STAT3 FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_SIRT1_STAT3FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 FAS_FRAP1_LC3_CDH2_FASLG_RPS19BP1_SESN1_STAT3ID2_HMGB1_HMGB2_MMP2_NAMPT_RPS19BP1_SESN3 AKT1_FAS_NNMT_BECN1_CDH2_RPS19BP1_STAT3_TP63FRAP1_LC3_TKT_BECN1_CDH2_FASLG_RAPTOR CSE1L_FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3FRAP1_LC3_NNMT_BECN1_CDH2_FASLG_STAT3 FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTOR_RPS19BP1FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1 AKT1_FAS_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63FRAP1_LC3_MMP9_BECN1_CASP3_CDH2_STAT3 FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63_TWIST1FAS_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 FAS_FRAP1_LC3_TKT_CASP3_CDH2_RPS19BP1_STAT3AIFM1_FAS_FRAP1_LC3_CDH2_RPS19BP1_STAT3 ID2_CDH2_FASLG_HMGB1_NAMPT_RPS19BP1_SESN3_STAT3AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63 FAS_FRAP1_LC3_BECN1_CDH2_FASLG_RAPTOR_RPS19BP1AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 CSE1L_FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3ID2_CDH2_HMGB1_MMP2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_HMGB1_STAT3AKT1_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_BECN1_CCNG2_CDH2_RPS19BP1_STAT3AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 FAS_FRAP1_LC3_TKT_BECN1_CDH2_FASLG_RAPTORATG5_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 AKT1_ATG12_FAS_TKT_BECN1_CDH2_STAT3_TP63FRAP1_LC3_CASP3_CDH2_HMGB1_RPS19BP1_STAT3 FRAP1_LC3_BECN1_CASP3_CDH2_FASLG_HMGB1_STAT3CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3 CDH1_ID2_MMP9_TCF3_CDH2_MMP2_RPS19BP1_SESN3。
27.如权利要求23所述的方法，所述方法用于预测A1组的存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表5]
一种两种的组合三种的组合四种的组合
ID2 CDH1_ID2 ATG12_CDH1_ID2 ATG12_CDH1_ID2_HMGB2
CDH1 ATG12_CDH1 CDH1_ID2_HMGB2 CDH1_ID2_AGER_HMGB2
LC3 LAMP1_ID2 ATG12_CDH1_HMGB2 ATG12_CDH1_ID2_AGER
TKT BNIP3_ID2 CDH1_ID2_AGER ATG12_CDH1_TCF3_HMGB2
AKT1 ATG12_ID2 DRAM_CDH1_ID2 ATG12_DRAM_CDH1_ID2
AIFM1 CDH1_HMGB2 E2F1_CDH1_ID2 AIFM1_CASP8_LC3_CDH1
BNIP3 ID2_HMGB2 CDH1_ID2_LAMP2 ATG12_CDH1_AGER_HMGB2
LAMP1 E2F1_ID2 TKT_CDH1_ID2 ATG12_CDH1_ID2_BECN1
FRAP1 TKT_ID2 LAMP1_CDH1_ID2 ATG12_DRAM_CDH1_HMGB2
DRAM_ID2 CDH1_ID2_MMP2 DRAM_CDH1_ID2_HMGB2
ATG5_ID2 ATG12_DRAM_CDH1 ATG12_CDH1_BHLHE41_HMGB2
ID2_BECN1 CSE1L_CDH1_ID2 CDH1_ID2_HMGB2_LAMP2
ID2_AGER CDH1_ID2_MMP9 ATG12_CDH1_BECN1_HMGB2
ID2_MMP2 BNIP3_CDH1_ID2 E2F1_CDH1_ID2_HMGB2
ATG3_ID2 CDH1_ID2_BECN1 ATG12_DIABLO_CDH1_BHLHE41
ID2_LAMP2 ATG12_CDH1_BHLHE41 CDH1_ID2_BECN1_HMGB2
ULK1_CDH1 ULK1_CDH1_ID2 ATG12_ATG5_CDH1_HMGB2
CSE1L_ID2 LC3_CDH1_ID2 DRAM_CDH1_ID2_AGER
TKT_CDH1 ATG12_CDH1_TCF3 LAMP1_CDH1_ID2_HMGB2
LC3_CDH1 ATG5_CDH1_ID2 ATG12_BNIP3_CDH1_ID2
ID2_MMP9 ATG3_CDH1_ID2 ATG12_CSE1L_CDH1_ID2
LC3_ID2 DIABLO_CDH1_ID2 ATG12_CDH1_ID2_MMP2
FRAP1_ID2 CASP8_CDH1_ID2 ATG12_CASP8_CDH1_ID2
CASP8_ID2 ATG12_ULK1_CDH1 ATG12_ATG3_CDH1_HMGB2
ID2_CIAP2 ATG12_CDH1_BECN1 ATG12_CDH1_ID2_MMP9
ID2_UVRAG ATG12_BNIP3_ID2 CDH1_ID2_HMGB2_MMP2
DIABLO_ID2 CDH1_ID2_CIAP2 ATG12_ATG3_CDH1_ID2
DRAM_CDH1 CBS_CDH1_ID2 ATG12_CASP8_CDH1_HMGB2
ID2_SIRT1 CDH1_ID2_HMGB1 ATG12_LAMP1_CDH1_ID2
FAS_ID2 CDH1_ID2_SIRT1 CDH1_ID2_AGER_BECN1
CDH1_AGER LAMP1_ID2_HMGB2 ATG12_FAS_CDH1_HMGB2
ID2_STAT3 CDH1_ID2_UVRAG ATG12_TKT_CDH1_ID2
CBS_ID2 AIFM1_LC3_CDH1 CDH1_ID2_MMP9_HMGB2
CDH1_MMP2 ATG12_CDH1_AGER ATG12_CDH1_HMGB1_HMGB2
AKT1_ID2 CDH1_ID2_STAT3 ATG12_CDH1_MMP9_HMGB2
ID2_CDH2 ATG12_LAMP1_ID2 ATG12_ATG5_CDH1_ID2
ATG7_ID2 ATG12_LC3_CDH1 ATG5_CDH1_ID2_HMGB2
ID2_HMGB1 CDH1_AGER_HMGB2 ATG3_CDH1_ID2_HMGB2
ULK1_ID2 FAS_CDH1_ID2 ATG12_DIABLO_CDH1_ID2
CDH1_LAMP2 ATG7_CDH1_ID2 CSE1L_CDH1_ID2_HMGB2
ATG5_CDH1 ATG12_CDH1_MMP2 ATG12_CDH1_CIAP2_HMGB2
ID2_SATB1 ATG12_CASP8_CDH1 ATG12_CDH1_ID2_UVRAG
CDH1_MMP9 ATG12_TKT_CDH1 ATG12_CDH1_HMGB2_SESN3
ID2_RPS19BP1 BNIP3_ID2_HMGB2 LC3_CDH1_ID2_AGER
ID2_TCF3 E2F1_ID2_HMGB2 ATG12_CDH1_HMGB2_SIRT1
CSE1L_CDH1 ATG12_CDH1_MMP9 ATG12_E2F1_CDH1_ID2
AIFM1_CDH1 ATG12_CDH1_SESN2 ATG12_FAS_CDH1_ID2
ID2_SESN3 CDH1_ID2_CDH2 AIFM1_ATG3_LC3_CDH1
ID2_SESN2 AKT1_CDH1_ID2 ATG12_CDH1_HMGB2_MMP2
LAMP1_CDH1 LAMP1_ID2_BECN1 BNIP3_CDH1_ID2_HMGB2
AIFM1_LC3 CDH1_ID2_TCF3 ATG12_ULK1_CDH1_HMGB2
E2F1_CDH1 ATG12_CDH1_UVRAG TKT_CDH1_ID2_HMGB2
ID2_NAMPT ATG12_FAS_CDH1 ATG12_CDH1_ID2_LAMP2
DIABLO_CDH1 LAMP1_TKT_ID2 ATG12_LC3_CDH1_ID2
BNIP3_CDH1 LAMP1_ID2_AGER ATG12_CDH1_HMGB2_UVRAG
AKT1_CDH1 DRAM_LAMP1_ID2 CASP8_CDH1_ID2_HMGB2
CASP8_CDH1 ATG12_DIABLO_CDH1 DIABLO_CDH1_ID2_HMGB2
CDH1_ID2_MMP9_TCF3
五种的组合六种的组合
ATG12_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_HMGB2
ATG12_DRAM_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_AGER_BECN1_HMGB2
DRAM_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_BECN1_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_RPS19BP1
ATG12_LAMP1_CDH1_ID2_HMGB2 ATG12_LAMP1_CDH1_ID2_AGER_HMGB2
ATG12_ATG5_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_MMP9_AGER_HMGB2
ATG12_E2F1_CDH1_ID2_HMGB2 ATG12_ATG3_CDH1_ID2_AGER_HMGB2
ATG12_ATG3_CDH1_ID2_HMGB2 ATG12_LC3_CDH1_ID2_AGER_HMGB2
CDH1_ID2_AGER_BECN1_HMGB2 ATG12_BNIP3_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_HMGB2_MMP2 ATG12_CDH1_ID2_AGER_HMGB2_SIRT1
ATG12_CASP8_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_MMP2
ATG12_BNIP3_CDH1_ID2_HMGB2 ATG12_CASP8_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_MMP9_HMGB2 ATG12_CDH1_ID2_AGER_CIAP2_HMGB2
LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_ATG5_CDH1_ID2_AGER_HMGB2
ATG12_CSE1L_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_TCF3_AGER_HMGB2
LC3_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_BECN1_HMGB2
ATG12_DIABLO_CDH1_ID2_HMGB2 ATG12_FAS_CDH1_ID2_AGER_HMGB2
CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_AGER_HMGB1_HMGB2
CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_HMGB2
CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_ATG3_DRAM_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_CIAP2_HMGB2 ATG12_ATG5_DRAM_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_HMGB2_UVRAG ATG12_DIABLO_CDH1_ID2_AGER_HMGB2
ATG12_DRAM_CDH1_ID2_AGER ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2
ATG12_DRAM_CDH1_TCF3_HMGB2 ATG12_CASP8_DRAM_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_AGER_BECN1 ATG12_DRAM_CDH1_ID2_HMGB2_MMP2
ATG12_DIABLO_CDH1_BHLHE41_HMGB2 ATG12_LAMP1_CDH1_ID2_BECN1_HMGB2
ATG12_DIABLO_CDH1_HMGB2_SESN3 ATG12_CBS_CDH1_ID2_AGER_HMGB2
ATG12_FAS_CDH1_ID2_HMGB2 ATG12_DRAM_CDH1_ID2_MMP9_HMGB2
ATG3_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_UVRAG
CDH1_ID2_AGER_HMGB2_MMP2 ATG12_E2F1_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_TCF3_HMGB2 ATG12_ATG5_CDH1_ID2_BECN1_HMGB2
ATG12_CDH1_TCF3_AGER_HMGB2 ATG12_DIABLO_CDH1_CIAP2_HMGB2_SESN3
ATG12_CDH1_ID2_HMGB1_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_HMGB2
AIFM1_ATG3_CASP8_LC3_CDH1 ATG12_DRAM_E2F1_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_HMGB2_SIRT1 ATG12_DIABLO_CDH1_TCF3_HMGB2_SESN3
ATG12_CDH1_TCF3_BECN1_HMGB2 AIFM1_ATG3_ATG5_CASP8_LC3_CDH1
ATG12_DIABLO_CDH1_TCF3_BHLHE41 ATG12_BNIP3_DRAM_CDH1_ID2_HMGB2
BNIP3_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_CDH1_ID2_HMGB2_SESN3
AIFM1_CASP8_DRAM_LC3_CDH1 AIFM1_ATG3_CASP8_LC3_CDH1_MMP9
ATG12_CDH1_ID2_HMGB2_LAMP2 ATG12_ATG3_CDH1_ID2_BECN1_HMGB2
ATG12_ATG3_CDH1_TCF3_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_STAT3
ATG12_LC3_CDH1_ID2_HMGB2 ATG12_DIABLO_DRAM_CDH1_ID2_HMGB2
ATG12_TKT_CDH1_ID2_HMGB2 ATG12_DRAM_CDH1_ID2_CIAP2_HMGB2
CASP8_CDH1_ID2_AGER_HMGB2 DRAM_LAMP1_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_TCF3_BHLHE41_HMGB2 DRAM_CDH1_ID2_AGER_BECN1_HMGB2
ATG5_CDH1_ID2_AGER_HMGB2 ATG12_BNIP3_CDH1_ID2_HMGB2_MMP2
ATG12_CSE1L_CDH1_ID2_AGER ATG12_BNIP3_CDH1_ID2_BECN1_HMGB2
CDH1_ID2_AGER_HMGB2_SIRT1 ATG12_CSE1L_CDH1_ID2_BECN1_HMGB2
CDH1_ID2_AGER_CIAP2_HMGB2 LAMP1_LC3_CDH1_ID2_AGER_HMGB2
CDH1_ID2_TCF3_AGER_HMGB2 ATG12_CDH1_ID2_BECN1_HMGB2_MMP2
AIFM1_CASP8_LC3_CDH1_MMP9 DRAM_LC3_CDH1_ID2_AGER_HMGB2
ATG12_DRAM_CDH1_ID2_BECN1 ATG12_DIABLO_CDH1_BHLHE41_HMGB2_SIRT1
AIFM1_CASP8_DIABLO_LC3_CDH1 ATG12_TKT_CDH1_ID2_AGER_HMGB2
CDH1_ID2_AGER_HMGB1_HMGB2 DRAM_CDH1_ID2_MMP9_AGER_HMGB2
ATG12_CDH1_ID2_HMGB2_RPS19BP1 ATG12_CDH1_ID2_MMP9_BECN1_HMGB2
ATG12_LC3_CDH1_AGER_HMGB2 CSE1L_DRAM_CDH1_ID2_AGER_HMGB2
FAS_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_FAS_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_MMP9_TCF3 ATG12_CDH1_ID2_MMP9_TCF3_HMGB2
七种的组合八种的组合
ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_ATG3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_DRAM_CDH1_TCF3_CIAP2_HMGB2_SESN3ATG12_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 ATG12_BNIP3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1ATG12_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_AGER_BECN1_HMGB2ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_DRAM_CDH1_TCF3_BHLHE41_HMGB2_SIRT1ATG12_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_DIABLO_CDH1_TCF3_BECN1_CIAP2_HMGB2_SESN3ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_LAMP1_LC3_CDH1_ID2_AGER_BECN1_HMGB2ATG12_LC3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1ATG12_DRAM_LC3_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2ATG12_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_LC3_CDH1_ID2_AGER_BECN1_HMGB2ATG12_DRAM_CDH1_ID2_AGER_HMGB2_SIRT1 ATG12_ATG3_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_MMP9_AGER_BECN1_HMGB2ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 ATG12_CASP8_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_LAMP1_LC3_CDH1_ID2_AGER_HMGB2ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_CDH1_TCF3_BECN1_BHLHE41_HMGB2_SIRT1ATG12_DRAM_CDH1_ID2_AGER_CIAP2_HMGB2 ATG12_CSE1L_LC3_CDH1_ID2_AGER_BECN1_HMGB2ATG12_LAMP1_LC3_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1ATG12_CASP8_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_TCF3_AGER_BECN1_HMGB2ATG12_CSE1L_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SESN2_SIRT1ATG12_BNIP3_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_ATG5_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 ATG12_ATG3_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2ATG12_CDH1_ID2_AGER_BECN1_HMGB2_MMP2 ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2_MMP2ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_MMP9_AGER_HMGB2ATG12_ATG3_CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2_RPS19BP1ATG12_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3 ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2 ATG12_CSE1L_CDH1_ID2_MMP9_AGER_BECN1_HMGB2ATG12_ATG3_DIABLO_CDH1_TCF3_HMGB2_SESN3 ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1ATG12_CSE1L_LC3_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_FAS_CDH1_TCF3_BECN1_BHLHE41_HMGB2ATG12_CSE1L_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_CSE1L_DRAM_LC3_CDH1_ID2_AGER_HMGB2ATG12_ATG5_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2ATG12_DRAM_CDH1_ID2_AGER_HMGB1_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_MMP2ATG12_DRAM_LAMP1_CDH1_ID2_BECN1_HMGB2 ATG12_ATG3_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2ATG12_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1 ATG12_CSE1L_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2ATG12_DRAM_FAS_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1ATG12_DIABLO_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_MMP9_AGER_HMGB2ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2ATG12_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2 ATG12_DRAM_FAS_CDH1_ID2_AGER_BECN1_HMGB2ATG12_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_CDH1_TCF3_BECN1_HMGB2_SESN3_SIRT1ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2 ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2_MMP2ATG12_ATG3_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_LC3_CDH1_ID2_MMP9_AGER_BECN1_HMGB2ATG12_CDH1_ID2_AGER_BECN1_HMGB2_SIRT1 AIFM1_CASP8_LAMP1_CDH1_AGER_CIAP2_HMGB2_RPS19BP1ATG12_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1 ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1AIFM1_ATG3_CASP8_CSE1L_LC3_CDH1_MMP9 ATG12_ATG3_DIABLO_CDH1_BECN1_HMGB2_SESN3_SIRT1ATG12_ATG3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_HMGB2_SESN3ATG12_LC3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_FAS_CDH1_TCF3_CIAP2_HMGB2_SESN3AIFM1_CASP8_LC3_CDH1_AGER_HMGB2_RPS19BP1 ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2_RPS19BP1ATG12_ATG5_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_CDH1_ID2_TCF3_AGER_BECN1_HMGB2ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_BNIP3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1AIFM1_ATG3_ATG5_CASP8_LC3_CDH1_MMP9 ATG12_DRAM_LC3_CDH1_ID2_MMP9_AGER_HMGB2ATG12_ATG5_DRAM_CDH1_ID2_BECN1_HMGB2 ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_RPS19BP1_SESN3ATG12_BNIP3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2_RPS19BP1ATG12_BNIP3_CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_LAMP1_CDH1_ID2_TCF3_AGER_BECN1_HMGB2ATG12_CDH1_ID2_MMP9_TCF3_AGER_HMGB2 ATG12_CDH1_ID2_MMP9_TCF3_AGER_BECN1_HMGB2。
28.如权利要求23所述的方法，所述方法用于预测A1组的无病存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表6]
一种两种的组合三种的组合四种的组合
MMP2 ID2_CDH2 FRAP1_CASP3_CDH2 FRAP1_TKT_CASP3_CDH2
ID2 FRAP1_TWIST1 ID2_CDH2_SESN3 ID2_CDH2_MMP2_SESN3
TWIST1 FRAP1_CASP3 ID2_CDH2_MMP2 CBS_ID2_CDH2_SESN3
BECN1 FRAP1_SESN1 FRAP1_CDH2_TWIST1 FRAP1_TKT_CDH2_TWIST1
BAX BAX_FRAP1 FRAP1_CDH2_SESN1 FRAP1_LC3_CASP3_CDH2
BCL2L1 FRAP1_NNMT FRAP1_NNMT_CDH2 FRAP1_NNMT_TKT_CDH2
CDH2 FRAP1_CCNG2 AIFM1_FRAP1_CDH2 ID2_CDH2_RPS19BP1_SESN3
FASLG BCL2L1_FRAP1 FRAP1_TKT_TWIST1 BAX_FRAP1_TKT_CDH2
AGER FRAP1_RAGE BAX_FRAP1_CDH2 BAX_FRAP1_LC3_CDH2
ATG12 AIFM1_FRAP1 FRAP1_LC3_TWIST1 ATG12_ID2_CDH2_SESN3
TKT BCL2_FRAP1 AKT1_ID2_CDH2 ATG12_ID2_MMP2_SESN3
FRAP1_VEGF ATG12_ID2_MMP2 FRAP1_LC3_CDH2_KIAA1967
FRAP1_PTEN FRAP1_CDH2_KIAA1967 AIFM1_FRAP1_TKT_CDH2
HMGB1_TWIST1 FRAP1_CCNG2_CDH2 FRAP1_TKT_CDH2_SESN1
ATG12_ID2 FRAP1_NNMT_MMP2 ID2_MMP2_RPS19BP1_SESN3
FRAP1_RAPTOR FRAP1_CDH2_RAGE FRAP1_CDH2_SESN1_STAT3
FRAP1_KIAA1967 BCL2L1_FRAP1_CDH2 FRAP1_LC3_CDH2_TWIST1
ID2_BECN1 FRAP1_TKT_CASP3 FRAP1_LC3_NNMT_CDH2
BECN1_SESN3 ATG12_MMP2_SESN3 FRAP1_LC3_CDH2_RAPTOR
ATG12_MMP2 FRAP1_CDH2_VEGF FRAP1_TKT_CCNG2_CDH2
CDH2_SESN3 ID2_CDH2_HMGB1 DIABLO_ID2_CDH2_SESN3
ID2_MMP2 FRAP1_PTEN_CDH2 ID2_CDH2_HMGB2_SESN3
FRAP1_XIAP CDH1_ID2_CDH2 FRAP1_TKT_CDH2_KIAA1967
AKT1_CDH2 FRAP1_CASP3_MMP2 FRAP1_LC3_CDH2_RAGE
FRAP1_PRKAA1 FRAP1_LC3_CASP3 BAX_FRAP1_TKT_MMP2
ID2_RPS19BP1 BCL2_FRAP1_CDH2 BCL2L1_FRAP1_TKT_CDH2
TKT_MMP2 BAX_FRAP1_TKT FRAP1_CASP3_CDH2_STAT3
BAX_TWIST1 FRAP1_CDH2_RAPTOR FRAP1_PTEN_TKT_CDH2
BECN1_FASLG BAX_FRAP1_LC3 FRAP1_ID2_CDH2_TWIST1
ATG12_SESN3 BAX_FRAP1_MMP2 ID2_CDH2_NAMPT_SESN3
CDH2_MMP2 FAS_ID2_CDH2 FRAP1_TKT_CDH2_VEGF
BECN1_MMP2 FRAP1_RPS19BP1_TWIST1 FRAP1_LC3_CDH2_VEGF
BAX_MMP2 FRAP1_LC3_NNMT FRAP1_NNMT_CDH2_MMP2
ID2_NAMPT FRAP1_LC3_RAGE AIFM1_FRAP1_LC3_CDH2
CASP8_ID2 FRAP1_HMGB1_TWIST1 FRAP1_LC3_PTEN_CDH2
ID2_TWIST1 FRAP1_SESN1_STAT3 FRAP1_TKT_CDH2_RAGE
MMP2_SESN3 FRAP1_TKT_SESN1 FRAP1_CDH2_HMGB1_TWIST1
AKT1_BAX ATG3_ID2_CDH2 FAS_FRAP1_CDH2_SESN1
FRAP1_TP63 FRAP1_ID2_CDH2 FRAP1_CASP3_CDH2_MMP2
BAX_LC3 FRAP1_TKT_CCNG2 DRAM_ID2_CDH2_SESN3
ATG12_FASLG FAS_FRAP1_TWIST1 LC3_HMGB1_STAT3_TWIST1
LC3_TWIST1 FRAP1_NNMT_TKT CASP8_ID2_CDH2_SESN3
AKT1_TWIST1 AIFM1_FRAP1_MMP2 FRAP1_TKT_CDH2_RAPTOR
ID2_FASLG ID2_CDH2_CIAP2 BCL2L1_FRAP1_LC3_CDH2
STAT3_TWIST1 FRAP1_LC3_VEGF FRAP1_CDH2_KIAA1967_MMP2
TKT_FASLG CDH2_MMP2_SESN3 FRAP1_TKT_CASP3_FASLG
AKT1_ATG12 ID2_CDH2_FASLG TKT_ID2_CDH2_MMP2
MMP2_NAMPT CBS_ID2_CDH2 FRAP1_NNMT_TKT_MMP2
ID2_SIRT1 FRAP1_LC3_CCNG2 FRAP1_TKT_CASP3_MMP2
ID2_AGER BCL2L1_FRAP1_TKT ID2_CDH2_CIAP2_SESN3
ATG7_TWIST1 FRAP1_ID2_TWIST1 FRAP1_CDH2_STAT3_TWIST1
AKT1_BCL2L1 AIFM1_FRAP1_LC3 CBS_FRAP1_CASP3_CDH2
BAX_TKT AIFM1_FRAP1_TKT BAX_FRAP1_CDH2_MMP2
KIAA1967_MMP2 ATG5_ID2_CDH2 ATG12_TKT_MMP2_SESN3
BCL2L1_MMP2 FRAP1_TKT_RAGE FRAP1_CDH1_CASP3_CDH2
ATG7_TP63 BCL2L1_FRAP1_MMP2 BAX_FRAP1_BECN1_CDH2
LC3_BECN1 FRAP1_CDH2_TP63 ID2_CDH2_HMGB1_MMP2
CDH1_ID2_MMP9_TCF3
五种的组合六种的组合
ID2_CDH2_MMP2_RPS19BP1_SESN3 AKT1_ATG12_FAS_CDH2_STAT3_TP63
ATG12_ID2_CDH2_MMP2_SESN3 AKT1_FAS_BECN1_CDH2_STAT3_TP63
FRAP1_LC3_CASP3_CDH2_STAT3 AKT1_FAS_CDH2_RPS19BP1_STAT3_TP63
ATG12_ID2_MMP2_RPS19BP1_SESN3 AKT1_FAS_LC3_CDH2_STAT3_TP63
AKT1_FAS_CDH2_STAT3_TP63 ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CASP3_CDH2_STAT3 AKT1_ATG12_BECN1_CDH2_STAT3_TP63
CASP8_ID2_CDH2_MMP2_SESN3 AKT1_ATG7_FAS_CDH2_RPS19BP1_TP63
FRAP1_TKT_CASP3_CDH2_FASLG ATG12_ID2_CDH2_HMGB1_MMP2_SESN3
BAX_FRAP1_LC3_TKT_CDH2 FRAP1_LC3_BECN1_CASP3_CDH2_STAT3
ID2_CDH2_HMGB2_MMP2_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_STAT3
DIABLO_ID2_CDH2_MMP2_SESN3 FRAP1_LC3_NNMT_BECN1_CDH2_STAT3
FRAP1_LAMP1_TKT_CASP3_CDH2 ID2_CDH2_HMGB2_MMP2_RPS19BP1_SESN3
CBS_ID2_CDH2_MMP2_SESN3 ATG12_ID2_CDH2_CIAP2_MMP2_SESN3
FRAP1_LC3_NNMT_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_SESN1_STAT3
FRAP1_TKT_CDH2_SESN1_STAT3 FRAP1_TKT_BECN1_CASP3_CDH2_STAT3
LC3_CDH2_HMGB1_STAT3_TWIST1 ATG12_FRAP1_ID2_CDH2_MMP2_SESN3
DRAM_ID2_CDH2_MMP2_SESN3 FAS_LC3_CDH2_HMGB1_STAT3_TWIST1
FRAP1_LC3_CDH2_SESN1_STAT3 ATG12_TKT_ID2_CDH2_MMP2_SESN3
CBS_FRAP1_TKT_CASP3_CDH2 ID2_CDH2_CIAP2_MMP2_RPS19BP1_SESN3
ID2_MMP2_NAMPT_RPS19BP1_SESN3 AKT1_CASP8_FAS_CDH2_STAT3_TP63
AKT1_ID2_CDH2_RPS19BP1_SESN3 AKT1_FAS_CASP3_CDH2_STAT3_TP63
ID2_CDH2_MMP2_NAMPT_SESN3 FAS_FRAP1_LC3_NNMT_CDH2_STAT3
AKT1_BECN1_CDH2_STAT3_TP63 FAS_FRAP1_TKT_CDH2_SESN1_STAT3
FAS_FRAP1_LC3_CDH2_RAPTOR ATG12_ID2_CDH2_MMP2_SESN3_STAT3
FRAP1_LC3_CDH2_STAT3_TWIST1 FRAP1_NNMT_TKT_BECN1_CDH2_STAT3
BAX_FRAP1_TKT_CDH2_MMP2 ATG12_FAS_FRAP1_CDH2_STAT3_TP63
FAS_FRAP1_LC3_CDH2_KIAA1967 ATG12_ATG3_ID2_CDH2_MMP2_SESN3
AKT1_ATG7_CDH2_RPS19BP1_TP63 DRAM_ID2_CDH2_MMP2_RPS19BP1_SESN3
FAS_FRAP1_LC3_CDH2_RAGE ATG12_CBS_ID2_CDH2_MMP2_SESN3
FAS_LC3_HMGB1_STAT3_TWIST1 ID2_CDH2_MMP2_RPS19BP1_SESN3_STAT3
FRAP1_LC3_TKT_CASP3_CDH2 FRAP1_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CASP3_CDH2_CIAP2 AKT1_ID2_CDH2_MMP2_RPS19BP1_SESN3
TKT_ID2_CDH2_MMP2_SESN3 FAS_FRAP1_LC3_CASP3_CDH2_STAT3
FRAP1_TKT_CDH2_KIAA1967_MMP2 ATG5_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CDH2_HMGB1_TWIST1 AKT1_FAS_CDH2_HMGB1_STAT3_TP63
BAX_FRAP1_LC3_BECN1_CDH2 CSE1L_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CDH2_STAT3_TWIST1 ATG3_ID2_CDH2_MMP2_RPS19BP1_SESN3
AKT1_ATG12_ID2_CDH2_SESN3 FRAP1_LC3_NNMT_TKT_CDH2_STAT3
BAX_FAS_FRAP1_LC3_CDH2 CBS_ID2_CDH2_MMP2_RPS19BP1_SESN3
ATG12_CBS_ID2_MMP2_SESN3 AKT1_ATG12_CDH2_HMGB1_STAT3_TP63
FAS_FRAP1_CDH2_SESN1_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR_RPS19BP1
FRAP1_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_ID2_CDH2_MMP2_SESN3
FAS_FRAP1_TKT_CDH2_SESN1 ATG12_ATG5_ID2_CDH2_MMP2_SESN3
FRAP1_LC3_CCNG2_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_STAT3_TP63
ID2_CDH2_MMP2_SESN3_UVRAG AKT1_FAS_BECN1_RPS19BP1_STAT3_TP63
ATG7_ID2_CDH2_MMP2_SESN3 FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR
ID2_CDH2_HMGB1_RPS19BP1_SESN3 FAS_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CDH2_MMP2_RAPTOR ATG12_CDH1_ID2_CDH2_MMP2_SESN3
FRAP1_LC3_BECN1_CDH2_RAPTOR FRAP1_LC3_TKT_CDH2_STAT3_TWIST1
ATG12_ID2_CDH2_FASLG_SESN3 CDH1_ID2_CDH2_MMP2_RPS19BP1_SESN3
ATG7_FRAP1_TKT_CASP3_CDH2 FAS_FRAP1_LC3_CDH2_KIAA1967_RPS19BP1
FRAP1_TKT_CASP3_CDH2_MMP2 FRAP1_LC3_CDH2_HMGB1_STAT3_TWIST1
FRAP1_LC3_CDH2_HMGB1_TWIST1 ATG12_ID2_CDH2_HMGB2_MMP2_SESN3
FRAP1_LC3_TKT_CDH2_KIAA1967 ATG12_FAS_ID2_CDH2_MMP2_SESN3
ATG7_ID2_CDH2_RPS19BP1_TP63 TKT_ID2_CDH2_MMP2_RPS19BP1_SESN3
BAX_FRAP1_TKT_BECN1_CDH2 BAX_FAS_FRAP1_LC3_TKT_CDH2
ATG3_FRAP1_TKT_CASP3_CDH2 ATG12_ID2_CDH2_MMP2_RPS19BP1_SESN3
CDH1_ID2_MMP9_TCF3_CDH2 CDH1_ID2_MMP9_TCF3_CDH2_SESN3
七种的组合八种的组合
AKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63AKT1_ATG12_FAS_CASP3_CDH2_STAT3_TP63 AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_LAMP1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_CDH2_HMGB2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63AIFM1_AKT1_ATG12_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_CDH2_CIAP2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_KIAA1967_STAT3_TP63AKT1_ATG12_FAS_CDH2_SESN2_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RAPTOR_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_NNMT_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_BCL2L1_FAS_BECN1_CDH2_STAT3_TP63AKT1_ATG12_FAS_CDH2_NAMPT_STAT3_TP63 AKT1_CASP8_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63AKT1_ATG12_FAS_CDH2_SIRT1_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_LC3_CDH2_STAT3_TP63AKT1_FAS_LC3_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_LC3_CDH2_STAT3_TP63AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RAPTOR_RPS19BP1_STAT3_TP63AKT1_ATG12_DRAM_FAS_CDH2_STAT3_TP63 AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_NNMT_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_BECN1_RPS19BP1_STAT3_TP63AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63AKT1_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_CDH2_HMGB1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63ATG12_FAS_FRAP1_LC3_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_LAMP1_CDH2_STAT3_TP63AKT1_ATG12_FAS_XIAP_CDH2_STAT3_TP63 AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63AKT1_ATG12_FAS_CDH2_LAMP2_STAT3_TP63 AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63AKT1_ATG12_ATG3_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63AKT1_ATG12_FAS_PTEN_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63AKT1_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH1_BECN1_CDH2_STAT3_TP63AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_TP63 AKT1_CASP8_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_LC3_CDH2_HMGB1_STAT3_TP63 AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_TKT_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_CIAP2_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 AKT1_FAS_CDH2_HMGB1_HMGB2_RPS19BP1_STAT3_TP63AKT1_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CASP3_CDH2_STAT3_TP63AKT1_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTOR AKT1_ATG12_E2F1_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_E2F1_FAS_CDH2_STAT3_TP63 AKT1_ATG12_DRAM_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63 AKT1_FAS_CASP3_CDH2_RPS19BP1_SESN2_STAT3_TP63AKT1_FAS_NNMT_BECN1_CDH2_STAT3_TP63 AKT1_FAS_CDH2_HMGB2_RPS19BP1_SESN2_STAT3_TP63AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CASP3_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_BECN1_CDH2_LAMP2_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 AKT1_FAS_TKT_CDH2_RPS19BP1_SESN2_STAT3_TP63FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 AKT1_ATG12_ATG3_FAS_CDH2_RPS19BP1_STATS_TP63ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3 AKT1_ATG12_FAS_XIAP_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_CDH2_RAPTOR_STAT3_TP63 AKT1_ATG12_CASP8FAS_NNMT_CDH2_STAT3_TP63FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_CASP8_FAS_CASP3_CDH2_STAT3_TP63FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1 AKT1_ATG12_FAS_CDH2_RPS19BP1_SIRT1_STAT3_TP63FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 AKT1_ATG12_BCL2L1_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_TKT_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_HMGB2_STAT3_TP63AKT1_CASP8_FAS_LC3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_NNMT_CDH2_STAT3_TP63AKT1_FAS_LC3_CASP3_CDH2_STAT3_TP63 AIFM1_AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63AKT1_FAS_LAMP1_BECN1_CDH2_STAT3_TP63 AKT1_ATG7_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_TP63 AKT1_ATG12_FAS_PTEN_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_TCF3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP8FAS_CDH2_CIAP2_STAT3_TP63CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3 AKT1_CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3。
29.如权利要求23所述的方法，所述方法用于预测A2组的复发预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表7]
一种两种的组合三种的组合四种的组合
TKT PRKAA1_LAMP2 LC3_SESN2_SIRT1 ATG5_LC3_SESN2_SIRT1
SESN2 TKT_SESN2 BNIP3_PRKAA1_LAMP2 ATG3_LC3_SESN2_SIRT1
LAMP2 ATG7_LAMP2 ATG5_LC3_SESN2 CSE1L_LC3_SESN2_SIRT1
LAMP2_SESN2 BNIP3_LC3_SESN2 ATG5_CSE1L_LC3_SESN2
AKT1_PRKAA1 ATG7_LC3_SESN2 BNIP3_LC3_SESN2_SIRT1
SESN2_SIRT1 AKT1_PRKAA1_LAMP2 FRAP1_LC3_SESN2_SIRT1
TKT_VEGF ATG7_TKT_SESN2 AKT1_ATG3_PRKAA1_LAMP2
ATG7_TKT DRAM_LC3_SESN2 ATG3_ATG5_LC3_SESN2
TKT_LAMP2 PRKAA1_AGER_LAMP2 ATG7_LC3_SESN2_SIRT1
BHLHE41_SESN2 PRKAA1_TKT_LAMP2 BNIP3_CSE1L_LC3_SESN2
TKT_BHLHE41 ATG7_TKT_LAMP2 TKT_LAMP2_SESN2_SIRT1
ATG5_SESN2 TKT_LAMP2_SESN2 CIAP2_LAMP2_SESN2_SIRT1
LAMP1_SESN2 TKT_LAMP2_VEGF ATG12_TKT_LAMP2_SESN2
CSE1L_LAMP2 ATG12_LC3_SESN2 ATG7_TKT_LAMP2_SESN2
ATG12_SESN2 ATG7_LAMP2_SESN2 AKT1_ATG7_PRKAA1_LAMP2
AKT1_TKT TKT_SESN2_SIRT1 ATG5_BNIP3_LC3_SESN2
E2F1_SESN2 E2F1_LC3_SESN2 ATG3_BNIP3_LC3_SESN2
ATG3_LAMP2 LC3_SESN2_UVRAG AKT1_PRKAA1_LAMP2_UVRAG
BNIP3_SESN2 PRKAA1_CCNG2_LAMP2 DRAM_LC3_SESN2_SIRT1
LC3_SESN2 AKT1_ATG7_TKT ATG7_CSE1L_LC3_SESN2
TWIST1_VEGF ATG5_PRKAA1_LAMP2 ATG7_FRAP1_LC3_SESN2
ATG7_LC3 ATG3_LAMP2_SESN2 BNIP3_PRKAA1_LAMP2_SESN2
CSE1L_SESN2 BNIP3_TKT_SESN2 ATG5_ATG7_LC3_SESN2
ATG5_LC3 LAMP2_SESN2_SIRT1 PRKAA1_TKT_LAMP2_SESN2
ATG7_SESN2 ATG7_PRKAA1_LAMP2 ATG3_ATG7_LC3_SESN2
LC3_ULK1 LAMP1_LC3_SESN2 BNIP3_PRKAA1_AGER_LAMP2
ATG3_TKT ATG12_PRKAA1_LAMP2 E2F1_LC3_SESN2_SIRT1
DRAM_SESN2 CASP8_PRKAA1_LAMP2 LC3_ID2_SESN2_SIRT1
PRKAA1_TKT AIFM1_TKT_SESN2 LC3_NAMPT_SESN2_SIRT1
BHLHE41_LAMP2 FRAP1_SESN2_SIRT1 ATG5_FRAP1_LC3_SESN2
LAMP2_VEGF PRKAA1_HMGB1_LAMP2 ATG7_BNIP3_LC3_SESN2
AKT1_VEGF LC3_BHLHE41_SESN2 LC3_RPS19BP1_SESN2_SIRT1
TKT_CIAP2 ATG12_TKT_SESN2 AKT1_ATG7_TKT_SESN2
CSE1L_BHLHE41 CSE1L_LAMP2_SESN2 BCL2L1_BNIP3_PRKAA1_LAMP2
LC3_BHLHE41 PRKAA1_CASP3_LAMP2 CSE1L_DRAM_LC3_SESN2
LC3_SIRT1 PRKAA1_LAMP2_RAGE DIABLO_LC3_SESN2_SIRT1
CSE1L_LAMP1 PRKAA1_LAMP2_SESN2 LC3_SESN2_SIRT1_STAT3
TKT_RPS19BP1 TKT_CIAP2_SESN2 ATG12_ATG5_LC3_SESN2
CBS_TKT BCL2L1_PRKAA1_LAMP2 BNIP3_PRKAA1_TCF3_LAMP2
CSE1L_BECN1 DIABLO_PRKAA1_LAMP2 LC3_SESN2_SIRT1_UVRAG
TKT_CDH1 PRKAA1_CDH1_LAMP2 BNIP3_PRKAA1_MMP9_LAMP2
TKT_HMGB1 CBS_PRKAA1_LAMP2 AKT1_LC3_SESN2_SIRT1
TKT_RAGE CSE1L_SESN2_SIRT1 AKT1_PRKAA1_CDH1_LAMP2
AIFM1_SESN2 ATG3_PRKAA1_LAMP2 CSE1L_LAMP1_LC3_SESN2
ATG7_TWIST1 PRKAA1_FASLG_LAMP2 ATG7_PRKAA1_TKT_LAMP2
BHLHE41_NAMPT PRKAA1_ID2_LAMP2 KIAA1967_LAMP2_SESN2_SIRT1
BNIP3_LC3 PRKAA1_LAMP2_SATB1 LC3_SESN2_SESN3_SIRT1
PRKAA1_SESN2 PRKAA1_LAMP2_SESN1 BNIP3_PRKAA1_HMGB1_LAMP2
ATG7_NAMPT AKT1_ATG7_PTEN CSE1L_LC3_SESN2_UVRAG
BECN1_SESN2 ATG7_TKT_BHLHE41 LC3_MMP9_SESN2_SIRT1
TKT_HMGB2 PRKAA1_LAMP2_MMP2 ATG3_LAMP2_SESN2_SIRT1
TKT_SIRT1 CSE1L_LAMP1_SESN2 BNIP3_PRKAA1_CCNG2_LAMP2
ATG5_CSE1L PRKAA1_LAMP2_SESN3 BNIP3_PRKAA1_LAMP2_SATB1
SESN2_UVRAG ATG3_TKT_SESN2 BNIP3_PRKAA1_LAMP2_SESN1
TKT_CASP3 ATG5_CSE1L_SESN2 ATG5_DRAM_LC3_SESN2
TKT_CDH2 ATG5_CSE1L_LC3 BNIP3_PRKAA1_CASP3_LAMP2
TKT_MMP2 FRAP1_PRKAA1_LAMP2 BNIP3_FRAP1_LC3_SESN2

五种的组合六种的组合
CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG5_LC3_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_FRAP1_LC3_SESN2_SIRT1 NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG7_FRAP1_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
TKT_CIAP2_LAMP2_SESN2_SIRT1 AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_FRAP1_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SESN1_SESN2_SIRT1
ATG5_BNIP3_LC3_SESN2_SIRT1 CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1
TKT_CDH1_LAMP2_SESN2_SIRT1 CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
CSE1L_FRAP1_LC3_SESN2_SIRT1 AKT1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_BNIP3_LC3_SESN2_SIRT1 ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_CSE1L_LC3_SESN2_SIRT1 FAS_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_LC3_LAMP2_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1
BNIP3_FRAP1_LC3_SESN2_SIRT1 TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
BNIP3_PRKAA1_TKT_LAMP2_SESN2 ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1
ATG12_TKT_LAMP2_SESN2_SIRT1 ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_ATG7_LC3_SESN2_SIRT1 BCL2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG7_BNIP3_TKT_LAMP2_SESN2 CIAP2_FASLG_LAMP2_RAGE_SESN2_SIRT1
AKT1_ATG7_BNIP3_PRKAA1_LAMP2 ATG5_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG7_LC3_SESN2_SIRT1 CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG5_BNIP3_LC3_SESN2 FRAP1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
BNIP3_CSE1L_LC3_SESN2_SIRT1 MMP9_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_DRAM_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1
AIFM1_CIAP2_LAMP2_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC3_SESN2_SIRT1
ATG7_TKT_LAMP2_SESN2_SIRT1 CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_CSE1L_FRAP1_LC3_SESN2 LAMP1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG7_LC3_NAMPT_SESN2_SIRT1 TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_E2F1_LC3_SESN2_SIRT1 ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1
BNIP3_CSE1L_FRAP1_LC3_SESN2 ATG3_ATG7_LC3_LAMP2_SESN2_SIRT1
ATG7_LC3_LAMP2_SESN2_SIRT1 ATG3_BNIP3_FRAP1_LC3_SESN2_SIRT1
AIFM1_BNIP3_PRKAA1_LAMP2_SESN2 ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1
ATG12_BNIP3_TKT_LAMP2_SESN2 ATG3_ATG5_BNIP3_LC3_SESN2_SIRT1
CIAP2_KIAA1967_LAMP2_SESN2_SIRT1 E2F1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG12_ATG5_BNIP3_LC3_SESN2 ATG3_BNIP3_LC3_LAMP2_SESN2_SIRT1
ATG3_ATG7_LC3_LAMP2_SESN2 ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1
ATG12_TKT_CIAP2_LAMP2_SESN2 ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1
ATG5_BNIP3_CSE1L_LC3_SESN2 TKT_CDH1_CIAP2_LAMP2_SESN2_SIRT1
AKT1_ATG7_PRKAA1_TKT_LAMP2 ATG5_BNIP3_E2F1_LC3_SESN2_SIRT1
ATG3_LC3_NAMPT_SESN2_SIRT1 ATG3_ATG7_LC3_NAMPT_SESN2_SIRT1
ATG3_CSE1L_LC3_SESN2_SIRT1 AIFM1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG7_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG5_LC3_ID2_SESN2_SIRT1 CBS_TKT_CIAP2_LAMP2_SESN2_SIRT1
BNIP3_E2F1_LC3_SESN2_SIRT1 ATG3_ATG5_LC3_ID2_SESN2_SIRT1
ATG3_LC3_ID2_SESN2_SIRT1 AIFM1_TKT_CIAP2_LAMP2_SESN2_SIRT1
ATG7_CSE1L_FRAP1_LC3_SESN2 ATG3_DRAM_FRAP1_LC3_SESN2_SIRT1
AIFM1_TKT_LAMP2_SESN2_SIRT1 ATG3_ATG5_E2F1_LC3_SESN2_SIRT1
LC3_CIAP2_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_LAMP2_SESN2_SIRT1
ATG12_TKT_CDH1_LAMP2_SESN2 ATG3_ATG5_LC3_SESN2_SIRT1_STAT3
ATG5_LC3_SESN2_SIRT1_STAT3 AIFM1_AKT1_LAMP2_SESN2_SIRT1_UVRAG
ATG3_DRAM_LC3_SESN2_SIRT1 AKT1_ATG7_TKT_LAMP2_SESN2_SIRT1
ATG5_DIABLO_LC3_SESN2_SIRT1 ATG3_ATG5_LC3_NAMPT_SESN2_SIRT1
ATG7_BNIP3_LC3_SESN2_SIRT1 ATG3_ATG5_DIABLO_LC3_SESN2_SIRT1
CDH2_CIAP2_LAMP2_SESN2_SIRT1 TKT_CDH1_HMGB1_LAMP2_SESN2_SIRT1
ATG3_ATG5_FRAP1_LC3_SESN2 ATG3_ATG5_LC3_LAMP2_SESN2_SIRT1
DRAM_TKT_LAMP2_SESN2_SIRT1 ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1
ATG12_ATG3_TKT_LAMP2_SESN2 BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG3_LC3_SESN2_SIRT1_STAT3 AKT1_ATG3_ATG5_LC3_SESN2_SIRT1
ATG5_LC3_SESN2_SIRT1_UVRAG AIFM1_BNIP3_PRKAA1_TKT_LAMP2_SESN2
TKT_CDH1_ID2_MMP9_TCF3_SESN2
七种的组合八种的组合
ATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_ID2_FASLG_LAMP2_SESN2_SIRT1MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 ATG5_FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN2_SIRT1LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1FAS_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1CIAP2_FASLG_LAMP2_NAMPT_SESN1_SESN2_SIRT1 ATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1_STAT3CIAP2_FASLG_LAMP2_MMP2_SESN1_SESN2_SIRT1 NNMT_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 FRAP1_AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1LC3_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN1_SESN2_SIRT1ATG5_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 TCF3_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 TCF3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SATB1_SESN2_SIRT1AKT1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FAS_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 NNMT_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1 ATG3_ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1NNMT_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 AKT1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 FRAP1_LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1AGER_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 FRAP1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1BCL2_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_ID2_FASLG_LAMP2_SESN2_SIRT1BCL2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1_STAT3ULK1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN1_SESN2_SIRT1LC3_CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1LC3_CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_BECN1_FASLG_LAMP2_SESN2_SIRT1AKT1_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC3_FASLG_LAMP2_SESN2_SIRT1FRAP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 NNMT_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1FRAP1_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SESN3_SIRT1CASP3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1CIAP2_FASLG_HMGB1_LAMP2_SESN1_SESN2_SIRT1 FAS_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN1_SESN2_SIRT1ATG5_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SATB1_SESN2_SIRT1ID2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BCL2_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1TCF3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ULK1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1FAS_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN2_SIRT1LAMP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BCL2_FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1 AKT1_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1TCF3_CIAP2_FASLG_LAMP2_SESN1_SESN2_SIRT1 ATG7_BNIP3_LC3_MMP9_FASLG_LAMP2_SESN2_SIRT1FRAP1_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 MMP9_AGER_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG3_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 FRAP1_LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1AKT1_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1NNMT_ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CASP3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CDH2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1MMP9_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1BNIP3_PRKAA1_CDH1_ID2_MMP9_TCF3_LAMP2 TKT_CDH1_ID2_MMP9_TCF3_LAMP2_SESN2_SIRT1。
30.如权利要求23所述的方法，所述方法用于预测A2组的存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表8]
一种两种的组合三种的组合四种的组合
BCL2L1 BCL2L1_NNMT BCL2L1_NNMT_PRKAA1 ATG3_BCL2L1_NNMT_PRKAA1
FAS BCL2L1_E2F1 BCL2L1_E2F1_PRKAA1 BCL2L1_TKT_CASP3_SESN2
LAMP1 BCL2L1_TKT ATG3_BCL2L1_PRKAA1 BCL2L1_ID2_CASP3_SESN2
BHLHE41 FAS_LAMP1 ATG3_BCL2L1_NNMT ATG3_BCL2L1_E2F1_PRKAA1
TKT BCL2L1_PRKAA1 ATG3_BCL2L1_E2F1 BCL2L1_NNMT_PRKAA1_HMGB1
LC3 FAS_BHLHE41 FAS_BHLHE41_SESN2 BCL2L1_NNMT_PRKAA1_MMP2
SESN2 FAS_TKT BCL2L1_PRKAA1_HMGB2 BCL2L1_NNMT_PRKAA1_CDH1
BCL2L1_CASP3 BCL2L1_CASP3_SESN2 FAS_TKT_CASP3_SESN2
ATG3_BCL2L1 BCL2L1_PRKAA1_TKT BCL2L1_NNMT_PRKAA1_VEGF
ATG7_BCL2L1 FAS_CASP3_SESN2 ATG7_BCL2L1_NNMT_PRKAA1
FAS_CASP3 BCL2L1_TKT_CASP3 BCL2L1_FRAP1_NNMT_PRKAA1
TKT_BHLHE41 FAS_TKT_CASP3 BCL2L1_NNMT_PRKAA1_ID2
BCL2L1_KIAA1967 BCL2L1_E2F1_TKT AIFM1_BCL2L1_NNMT_PRKAA1
FAS_PRKAA1 BCL2L1_NNMT_TKT BCL2L1_TKT_BHLHE41_CASP3
FAS_KIAA1967 FAS_TKT_BHLHE41 BCL2L1_NNMT_PRKAA1_CDH2
FAS_SESN2 FAS_TKT_SESN2 BCL2L1_CSE1L_NNMT_PRKAA1
BCL2L1_HMGB2 FAS_LAMP1_BHLHE41 BCL2L1_NNMT_PRKAA1_HMGB2
BCL2L1_VEGF FAS_LAMP1_SESN2 BCL2L1_CBS_NNMT_PRKAA1
BNIP3_FAS ATG3_BCL2L1_TKT FAS_TKT_SESN2_TP63
FAS_TWIST1 ATG7_BCL2L1_PRKAA1 BCL2L1_DRAM_NNMT_PRKAA1
BNIP3_TKT DIABLO_FAS_BHLHE41 BCL2L1_NNMT_PRKAA1_ULK1
BCL2L1_CSE1L TKT_SESN2_TP63 BNIP3_TKT_CASP3_SESN2
TKT_SESN2 FAS_PRKAA1_TKT ATG5_BCL2L1_NNMT_PRKAA1
BCL2L1_FRAP1 ATG7_BCL2L1_NNMT BCL2L1_DIABLO_NNMT_PRKAA1
LAMP1_SESN2 BCL2L1_BNIP3_TKT BCL2L1_NNMT_CASP3_SESN2
LC3_BHLHE41 BNIP3_FAS_TKT FAS_TKT_BHLHE41_CASP3
BCL2L1_BNIP3 BCL2L1_NNMT_CASP3 BCL2L1_NNMT_PRKAA1_TKT
BCL2L1_LC3 TKT_BHLHE41_CASP3 BNIP3_FAS_TKT_CASP3
ATG5_BCL2L1 ATG3_BCL2L1_CASP3 ATG3_ATG7_BCL2L1_PRKAA1
BCL2L1_CBS BCL2L1_PRKAA1_CASP3 FAS_ID2_CASP3_SESN2
CSE1L_LAMP1 BCL2L1_PRKAA1_MMP2 BCL2L1_NNMT_PRKAA1_CASP3
E2F1_FAS FAS_BHLHE41_CASP3 ATG3_BCL2L1_PRKAA1_HMGB2
AIFM1_BCL2L1 FAS_TKT_KIAA1967 FAS_LC3_BHLHE41_SESN2
BHLHE41_SESN2 FAS_TKT_TWIST1 ATG3_BCL2L1_BNIP3_NNMT
CASP8_FAS BCL2L1_E2F1_NNMT BCL2L1_CASP8_NNMT_PRKAA1
FAS_NAMPT BCL2L1_FRAP1_NNMT FAS_BHLHE41_CASP3_SESN2
FAS_TP63 BCL2L1_TKT_BHLHE41 BCL2L1_BNIP3_NNMT_TKT
LAMP1_BHLHE41 BCL2L1_TKT_SESN2 DIABLO_FAS_BHLHE41_SESN2
ATG12_FAS FAS_KIAA1967_SESN2 ATG3_BCL2L1_PRKAA1_TKT
BCL2L1_MMP2 DIABLO_FAS_LAMP1 BCL2L1_NNMT_PRKAA1_MMP9
BHLHE41_CASP3 ATG3_BCL2L1_KIAA1967 BNIP3_FAS_CASP3_SESN2
FAS_HMGB1 ATG7_BCL2L1_E2F1 FAS_LAMP1_BHLHE41_SESN2
FAS_VEGF FAS_BHLHE41_SATB1 BCL2L1_CASP3_SESN1_SESN2
LAMP1_TCF3 ATG3_ATG7_BCL2L1 BCL2L1_NNMT_PRKAA1_SIRT1
BCL2L1_ULK1 ATG7_BCL2L1_TKT DIABLO_FAS_LAMP1_BHLHE41
FAS_LC3 BCL2L1_BNIP3_NNMT FAS_TKT_CASP3_SIRT1
NNMT_BHLHE41 BCL2L1_PRKAA1_VEGF E2F1_FAS_BHLHE41_SESN2
BCL2L1_FAS BCL2L1_BHLHE41_CASP3 FAS_TKT_CASP3_FASLG
TKT_TP63 FAS_SESN2_TP63 FAS_TKT_HMGB1_SESN2
AKT1_BCL2L1 TKT_BHLHE41_TP63 FAS_CASP3_HMGB1_SESN2
ATG12_BCL2L1 AIFM1_BCL2L1_NNMT BAX_BCL2L1_NNMT_PRKAA1
FAS_HMGB2 BCL2L1_CSE1L_NNMT BCL2L1_E2F1_NNMT_PRKAA1
BCL2L1_ID2 BCL2L1_E2F1_FRAP1 ATG3_BCL2L1_PRKAA1_MMP2
BCL2L1_RPS19BP1 BNIP3_FAS_CASP3 FAS_TKT_KIAA1967_SESN2
TKT_SATB1 FAS_TKT_SATB1 BNIP3_FAS_TKT_TWIST1
FAS_XIAP BCL2L1_CSE1L_PRKAA1 ATG3_BCL2L1_BNIP3_TKT
BCL2_BCL2L1 BCL2L1_NNMT_VEGF BCL2L1_NNMT_PRKAA1_PTEN

五种的组合六种的组合
BCL2L1_NNMT_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2
BCL2L1_PTEN_TKT_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_HMGB1 ATG3_BCL2L1_NNMT_PRKAA1_CASP3_SIRT1
BCL2L1_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_SESN1_SESN2
BCL2L1_TKT_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_ID2 BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2
BCL2L1_BNIP3_TKT_CASP3_SESN2 FAS_TKT_CASP3_HMGB1_SESN2_TP63
ATG3_BCL2L1_NNMT_PRKAA1_CDH1 ATG3_BCL2L1_NNMT_PRKAA1_KIAA1967_SIRT1
BCL2L1_TKT_CASP3_RAGE_SESN2 ATG3_BCL2L1_NNMT_ID2_CASP3_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_ULK1 ATG3_BCL2L1_NNMT_PRKAA1_HMGB1_VEGF
FAS_TKT_CASP3_HMGB1_SESN2 BCL2L1_PTEN_TKT_CASP3_SESN1_SESN2
FAS_TKT_CASP3_SESN2_TP63 BCL2L1_NNMT_ID2_AGER_CASP3_SESN2
ATG3_BCL2L1_FRAP1_NNMT_PRKAA1 BCL2L1_NNMT_ID2_BECN1_CASP3_SESN2
FAS_TKT_HMGB1_SESN2_TP63 BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN2
AIFM1_ATG3_BCL2L1_NNMT_PRKAA1 BCL2L1_PTEN_TKT_XIAP_CASP3_SESN2
BCL2L1_ID2_CASP3_SESN1_SESN2 ATG12_BCL2L1_NNMT_ID2_CASP3_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_MMP2 BNIP3_TKT_XIAP_CASP3_RAGE_SESN2
BCL2L1_TKT_CASP3_SESN1_SESN2 BCL2L1_NNMT_ID2_CASP3_CCNG2_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_VEGF AIFM1_BCL2L1_NNMT_ID2_CASP3_SESN2
BCL2L1_TKT_ID2_CASP3_SESN2 BCL2L1_PTEN_TKT_CASP3_RAGE_SESN2
ATG3_BCL2L1_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_CDH2_SESN2
BNIP3_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_LAMP2_SESN2
BCL2L1_NNMT_PRKAA1_ID2_SESN2 ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_FASLG
BCL2L1_NNMT_PRKAA1_HMGB1_VEGF BCL2L1_NNMT_ID2_CASP3_SESN2_SESN3
ATG3_BCL2L1_NNMT_PRKAA1_CDH2 BCL2L1_CSE1L_NNMT_ID2_CASP3_SESN2
ATG3_BCL2L1_LAMP1_NNMT_PRKAA1 BAX_BCL2L1_NNMT_ID2_CASP3_SESN2
BCL2L1_NNMT_ID2_SESN2_UVRAG BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2
ATG3_ATG7_BCL2L1_NNMT_PRKAA1 BCL2L1_NNMT_ID2_CASP3_MMP2_SESN2
ATG3_BCL2L1_CBS_NNMT_PRKAA1 BNIP3_PTEN_TKT_XIAP_CASP3_SESN2
BCL2L1_ID2_CASP3_RPS19BP1_SESN2 BCL2L1_BNIP3_TKT_ID2_CASP3_SESN2
BNIP3_FAS_TKT_CASP3_SESN2 BCL2L1_BNIP3_TKT_CASP3_SESN1_SESN2
ATG3_BCL2L1_DRAM_NNMT_PRKAA1 ATG3_ATG7_BCL2L1_NNMT_PRKAA1_HMGB1
ATG7_BCL2L1_NNMT_PRKAA1_HMGB1 BCL2L1_CASP8_NNMT_ID2_CASP3_SESN2
BCL2L1_NNMT_PRKAA1_HMGB1_HMGB2 ATG5_BCL2L1_NNMT_ID2_CASP3_SESN2
BCL2L1_FAS_TKT_CASP3_SESN2 BCL2L1_NNMT_CDH1_ID2_CASP3_SESN2
ATG3_BCL2L1_CSE1L_NNMT_PRKAA1 ATG3_BCL2L1_NNMT_PRKAA1_ID2_VEGF
ATG3_BCL2L1_DIABLO_NNMT_PRKAA1 BCL2L1_NNMT_PRKAA1_ID2_CASP3_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_SIRT1 BCL2L1_TKT_XIAP_CASP3_SESN1_SESN2
BCL2L1_CASP8_ID2_CASP3_SESN2 BCL2L1_NNMT_XIAP_ID2_CASP3_SESN2
BCL2L1_DIABLO_ID2_CASP3_SESN2 BCL2L1_DIABLO_NNMT_ID2_CASP3_SESN2
BCL2L1_TKT_CASP3_SESN2_STAT3 BCL2L1_TKT_XIAP_CASP3_HMGB1_SESN2
BCL2L1_NNMT_PRKAA1_ID2_VEGF BCL2L1_BNIP3_TKT_CASP3_RAGE_SESN2
BCL2L1_ID2_CASP3_HMGB2_SESN2 BCL2L1_TKT_BHLHE41_CASP3_SESN1_SESN2
BCL2L1_TKT_CASP3_SESN2_SESN3 BCL2L1_TKT_CASP3_HMGB1_RAGE_SESN2
BCL2L1_TKT_CASP3_CCNG2_SESN2 BCL2L1_PTEN_TKT_CASP3_CCNG2_SESN2
FAS_TKT_CASP3_FASLG_SESN2 BCL2L1_PRKAA1_TKT_XIAP_CASP3_SESN2
FAS_TKT_CASP3_SESN2_SIRT1 BCL2L1_TKT_CASP3_HMGB1_SESN1_SESN2
BCL2L1_NNMT_ID2_KIAA1967_SESN2 BNIP3_FAS_TKT_CASP3_HMGB1_SESN2
ATG5_BCL2L1_ID2_CASP3_SESN2 FAS_TKT_XIAP_CASP3_HMGB1_SESN2
BCL2L1_NNMT_PRKAA1_CASP3_SIRT1 BCL2L1_NNMT_ID2_SESN1_SESN2_UVRAG
BCL2L1_TKT_XIAP_BHLHE41_CASP3 FAS_TKT_HMGB1_KIAA1967_SESN2_TP63
FAS_TKT_XIAP_CASP3_SESN2 BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN2
BCL2L1_CDH1_ID2_CASP3_SESN2 BCL2L1_PTEN_TKT_ID2_CASP3_SESN2
BCL2L1_TKT_CASP3_SESN2_SIRT1 BCL2L1_ID2_CASP3_RAGE_RPS19BP1_SESN2
ATG7_BCL2L1_NNMT_PRKAA1_ID2 BNIP3_TKT_XIAP_CASP3_HMGB1_SESN2
BCL2_BCL2L1_TKT_CASP3_SESN2 ATG3_ATG7_BCL2L1_NNMT_PRKAA1_ID2
BCL2L1_ID2_CASP3_CDH2_SESN2 BCL2L1_BNIP3_NNMT_TKT_CASP3_SESN2
七种的组合八种的组合
BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_PTEN_XIAP_ID2_CASP3_SESN2BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_SESN3BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2ATG3_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2_SESN3BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN1_SESN2ATG3_BCL2L1_NNMT_PRKAA1_ID2_CASP3_SIRT1 BCL2_BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2BCL2L1_CASP8_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_RAGE_SESN2BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN2 BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN1_SESN2ATG3_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_HMGB1_SESN2BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_ID2_CASP3_SESN2BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_RAGE_SESN2BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2_SESN3 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2_SESN3BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN1_SESN2BNIP3_PTEN_TKT_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN1_SESN2ATG3_BCL2L1_NNMT_PRKAA1_XIAP_CASP3_SIRT1 BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_RPS19BP1_SESN2BCL2L1_BNIP3_NNMT_TKT_XIAP_CASP3_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2BCL2_BCL2L1_TKT_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG BCL2L1_NNMT_ID2_BHLHE41_CASP3_HMGB1_SESN1_SESN2ATG3_BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2 ATG3_BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2BCL2L1_NNMT_PRKAA1_ID2_CASP3_RAGE_SESN2 ATG5_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BCL2L1_PRKAA1_TKT_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_MMP2_SESN2BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2 BCL2L1_BNIP3_TKT_XIAP_CASP3_RAGE_RPS19BP1_SESN2BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2_SESN3ATG3_BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_MMP2_SESN2BCL2L1_BNIP3_NNMT_TKT_ID2_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CCNG2_SESN2BCL2L1_NNMT_ID2_CASP3_HMGB1_RAGE_SESN2 BCL2_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2BCL2L1_PRKAA1_TKT_XIAP_CASP3_RAGE_SESN2 ATG5_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2BCL2L1_PRKAA1_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_AGER_CASP3_SESN2BCL2L1_TKT_BHLHE41_CASP3_RAGE_SESN1_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN1_SESN2BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_LAMP2_SESN2BCL2L1_NNMT_ID2_BECN1_CASP3_RAGE_SESN2 BCL2L1_BNIP3_NNMT_TKT_XIAP_ID2_CASP3_SESN2BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_SESN2 ATG12_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BNIP3_TKT_XIAP_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_BECN1_CASP3_SESN2BCL2L1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_CDH2_SESN2BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN1_SESN2 AIFM1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN2 ATG12_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2AIFM1_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 BAX_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BCL2L1_NNMT_ID2_CASP3_CDH2_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_LAMP2_SESN2BCL2L1_NNMT_CDH1_ID2_CASP3_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_AGER_CASP3_SESN2BCL2L1_NNMT_ID2AGER_CASP3_RAGE_SESN2 AKT1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BNIP3_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 BAX_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2BNIP3_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_PTEN_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2BNIP3_TKT_XIAP_CASP3_HMGB1_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_BECN1_CASP3_SESN2BCL2L1_NNMT_ID2_CASP3_MMP2_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CDH2_SESN2ATG5_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 BCL2L1_CASP8_NNMT_ID2_CASP3_HMGB1_RAGE_SESN2BCL2L1_BNIP3_TKT_ID2_CASP3_RPS19BP1_SESN2 BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN1_SESN2BCL2L1_NNMT_ID2_CASP3_RAGE_SESN1_SESN2 ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG_KIAA1967BCL2L1_NNMT_TKT_ID2_BHLHE41_CASP3_SESN2 BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2_SESN3BCL2L1_PTEN_TKT_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_CSE1L_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BCL2L1_CSE1L_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_STAT3BCL2L1_PTEN_TKT_CASP3_RAGE_SESN1_SESN2 BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2BNIP3_TKT_XIAP_CASP3_CCNG2_RAGE_SESN2 BCL2L1_NNMT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3ATG3_BCL2L1_BNIP3_TKT_CASP3_FASLG_SESN2 BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN1_SESN2BCL2L1_BNIP3_E2F1_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_ID2_HMGB1_HMGB2_SESN1_SESN2BCL2L1_CDH1_ID2_MMP9_TCF3_CASP3_SESN2 BCL2L1_TKT_CDH1_ID2_MMP9_TCF3_CASP3_SESN2。
31.如权利要求23所述的方法，所述方法用于预测A2组的无病存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表9]
一种两种的组合三种的组合四种的组合
SESN2 TKT_SESN2 ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SESN2
TKT BHLHE41_SESN2 FRAP1_SESN2_SIRT1 CSE1L_FRAP1_SESN2_SIRT1
LAMP2 LAMP2_SESN2 ATG5_LC3_SESN2 ATG7_TKT_LAMP2_SESN2
BHLHE41 ATG5_SESN2 ATG5_FRAP1_SESN2 ATG5_FRAP1_SESN2_SIRT1
CSE1L LAMP1_SESN2 TKT_LAMP2_SESN2 AKT1_ATG7_TKT_SESN2
SESN2_SIRT1 AIFM1_TKT_SESN2 ATG5_CSE1L_LC3_SESN2
E2F1_SESN2 ATG5_CSE1L_SESN2 FRAP1_LC3_SESN2_SIRT1
ATG12_SESN2 LC3_SESN2_SIRT1 CSE1L_FRAP1_LAMP1_SESN2
TKT_VEGF ATG12_TKT_SESN2 ATG7_TKT_SESN2_SESN3
CSE1L_BECN1 CSE1L_LAMP1_SESN2 ATG5_FRAP1_LC3_SESN2
CSE1L_SESN2 TKT_HMGB2_SESN2 ATG7_CSE1L_FRAP1_SESN2
ATG7_TKT ATG5_TKT_SESN2 CSE1L_LC3_SESN2_SIRT1
FASLG_SESN2 TKT_CDH1_SESN2 ATG5_LC3_SESN2_SIRT1
PRKAA1_LAMP2 TKT_SESN2_SESN3 ATG7_TKT_FASLG_SESN2
PRKAA1_SESN2 TKT_SESN2_VEGF ATG7_TKT_AGER_SESN2
TKT_BHLHE41 CSE1L_BHLHE41_SESN2 ATG7_TKT_HMGB1_SESN2
CSE1L_BHLHE41 PRKAA1_TKT_SESN2 ATG7_TKT_MMP2_SESN2
ATG7_SESN2 ATG3_TKT_SESN2 BNIP3_CSE1L_FRAP1_SESN2
CSE1L_LAMP2 TKT_RPS19BP1_SESN2 ATG5_ATG7_TKT_SESN2
FAS_SESN2 CBS_TKT_SESN2 ATG7_BCI2_TKT_SESN2
HMGB2_SESN2 CSE1L_LAMP2_SESN2 ATG7_BNIP3_TKT_SESN2
CSE1L_LAMP1 TKT_SESN2_SIRT1 FAS_FRAP1_SESN2_SIRT1
BECN1_SESN2 AKT1_TKT_SESN2 AIFM1_ATG7_TKT_SESN2
NNMT_SESN2 CSE1L_SESN2_SIRT1 ATG12_TKT_LAMP2_SESN2
AIFM1_SESN2 TKT_CDH2_SESN2 ATG7_TKT_BHLHE41_SESN2
BAX_SESN2 BNIP3_TKT_SESN2 ATG7_TKT_ID2_SESN2
DRAM_SESN2 NNMT_TKT_SESN2 CSE1L_DRAM_FRAP1_SESN2
CSE1L_ULK1 TKT_AGER_SESN2 CSE1L_FRAP1_SESN2_UVRAG
KIAA1967_SESN2 TKT_BHLHE41_SESN2 ATG7_LAMP1_TKT_SESN2
SESN2_VEGF TKT_HMGB1_SESN2 ATG7_BCL2L1_TKT_SESN2
BNIP3_SESN2 TKT_MMP2_SESN2 ATG7_TKT_CCNG2_SESN2
SESN2_UVRAG E2F1_TKT_SESN2 CSE1L_E2F1_FRAP1_SESN2
TWIST1_VEGF NAMPT_SESN2_SIRT1 CSE1L_LAMP1_LC3_SESN2
PRKAA1_FASLG TKT_KIAA1967_SESN2 PRKAA1_TKT_LAMP2_SESN2
TKT_RPS19BP1 DRAM_TKT_SESN2 ATG7_CBS_TKT_SESN2
PRKAA1_TKT TKT_CIAP2_SESN2 ATG7_LC3_TKT_SESN2
ATG7_LAMP2 TKT_MMP9_SESN2 ATG7_NNMT_TKT_SESN2
AGER_SESN2 ATG5_NAMPT_SESN2 ATG7_TKT_CIAP2_SESN2
CDH2_SESN2 ATG7_FRAP1_SESN2 ATG7_TKT_SESN2_STAT3
AKT1_PRKAA1 CSE1L_E2F1_SESN2 ATG7_PTEN_TKT_SESN2
ULK1_SESN2 LAMP1_TKT_SESN2 ATG7_TKT_CASP3_SESN2
MMP2_SESN2 LC3_TKT_SESN2 ATG7_TKT_CDH2_SESN2
ATG5_CSE1L TKT_CASP3_SESN2 ATG7_TKT_HMGB2_SESN2
HMGB1_SESN2 TKT_CCNG2_SESN2 ATG7_TKT_NAMPT_SESN2
AKT1_TKT TKT_ID2_SESN2 ATG7_TKT_RAPTOR_SESN2
CBS_SESN2 TKT_RAPTOR_SESN2 ATG7_TKT_SESN2_SIRT1
FRAP1_SESN2 TKT_XIAP_SESN2 ATG7_FRAP1_LC3_SESN2
CIAP2_SESN2 BAX_TKT_SESN2 ATG7_TKT_BECN1_SESN2
BCL2_SESN2 BCL2_TKT_SESN2 ATG7_DIABLO_TKT_SESN2
CCNG2_SESN2 ATG12_CSE1L_SESN2 ATG7_FRAP1_SESN2_SIRT1
BCL2L1_SESN2 BCL2L1_TKT_SESN2 ATG12_CSE1L_FRAP1_SESN2
CSE1L_UVRAG CASP8_TKT_SESN2 ATG7_TKT_XIAP_SESN2
RAPTOR_SESN2 DIABLO_TKT_SESN2 ATG7_E2F1_TKT_SESN2
XIAP_SESN2 FAS_BHLHE41_SESN2 ATG7_TKT_MMP9_SESN2
CASP3_SESN2 FRAP1_TKT_SESN2 ATG7_TKT_RAGE_SESN2
CASP8_SESN2 PTEN_TKT_SESN2 ATG3_ATG7_TKT_SESN2
LC3_SESN2 TKT_RAGE_SESN2 ATG7_CSE1L_LC3_SESN2
五种的组合六种的组合
ATG5_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1
CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1
ATG5_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_FRAP1_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2
ATG7_CSE1L_FRAP1_LC3_SESN2 ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG7_FRAP1_LC3_SESN2_SIRT1 ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_FRAP1_LAMP1_SESN2 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2
AKT1_ATG7_TKT_LAMP2_SESN2 ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1
ATG5_FRAP1_LAMP1_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2
CSE1L_FRAP1_LAMP1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1
ATG3_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2
AKT1_ATG5_CSE1L_FRAP1_SESN2 ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1
ATG5_CSE1L_DIABLO_FRAP1_SESN2 ATG5_CSE1L_FRAP1_LC3_ID2_SESN2
ATG5_CSE1L_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3
CSE1L_FRAP1_SESN2_SIRT1_UVRAG CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG7_TKT_LAMP2_SESN2_SESN3 AKT1_CSE1L_FRAP1_LC3_SESN2_SIRT1
CSE1L_FRAP1_SATB1_SESN2_SIRT1 ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1
CSE1L_FRAP1_CDH1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG7_TKT_FASLG_LAMP2_SESN2 ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG5_CSE1L_FRAP1_ID2_SESN2 CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1
AKT1_ATG7_TKT_SESN2_SESN3 CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1
ATG7_TKT_LAMP2_MMP2_SESN2 CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1
AKT1_CSE1L_FRAP1_SESN2_SIRT1 AKT1_ATG5_FRAP1_LC3_SESN2_SI RT1
BNIP3_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2
ATG5_CSE1L_FRAP1_SESN2_SESN3 ATG5_FRAP1_LC3_ID2_SESN2_SIRT1
CSE1L_FRAP1_LAMP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LAMP1_SESN2_SIRT1
ATG3_ATG5_CSE1L_FRAP1_SESN2 ATG3_ATG7_FRAP1_LC3_SESN2_SIRT1
CSE1L_DRAM_FRAP1_LC3_SESN2 ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1
ATG3_CSE1L_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LAMP1_LC3_SESN2
ATG5_ATG7_FRAP1_LC3_SESN2 ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2
ATG5_FAS_FRAP1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3
CSE1L_FRAP1_SESN2_SESN3_SIRT1 BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1
CSE1L_DRAM_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_SESN2_SIRT1_UVRAG
CSE1L_DIABLO_FRAP1_SESN2_SIRT1 ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2
ATG7_CSE1L_FRAP1_SESN2_SIRT1 ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1
ATG5_CSE1L_FRAP1_CDH1_SESN2 ATG5_ATG7_FRAP1_LAMP1_SESN2_SIRT1
ATG7_TKT_FASLG_SESN2_SESN3 ATG5_CSE1L_FRAP1_CDH1_SESN2_SIRT1
ATG7_TKT_HMGB1_LAMP2_SESN2 ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3
ATG7_TKT_AGER_LAMP2_SESN2 ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2
ATG3_ATG5_FRAP1_LC3_SESN2 ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG3_ATG5_FRAP1_SESN2_SIRT1 ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_FRAP1_SATB1_SESN2 ATG3_ATG5_FRAP1_LAMP1_SESN2_SIRT1
CSE1L_FRAP1_ID2_SESN2_SIRT1 CSE1L_FRAP1_LC3_CDH1_SESN2_SIRT1
ATG7_BNIP3_TKT_LAMP2_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_STAT3
ATG5_ATG7_CSE1L_FRAP1_SESN2 AIFM1_ATG12_TKT_FASLG_LAMP2_SESN2
ATG5_LC3_NAMPT_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_UVRAG
ATG12_ATG5_CSE1L_FRAP1_SESN2 CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1
CSE1L_FRAP1_SESN2_SIRT1_STAT3 CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1
CSE1L_FRAP1_LC3_SESN2_UVRAG ATG5_CSE1L_FRAP1_LC3_RPS19BP1_SESN2
AKT1_ATG7_TKT_MMP2_SESN2 AKT1_ATG5_CSE1L_FRAP1_SESN2_SIRT1
ATG5_BNIP3_CSE1L_FRAP1_SESN2 ATG5_CSE1L_E2F1_FRAP1_LC3_SESN2
CSE1L_FRAP1_MMP9_SESN2_SIRT1 CSE1L_E2F1_FRAP1_LC3_SESN2_SIRT1
BNIP3_CSE1L_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2
AKT1_ATG7_TKT_HMGB1_SESN2 ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2
AIFM1_AKT1_ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SATB1_SESN2_SIRT1
AKT1_ATG5_ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SESN2_SESN3_SIRT1
ATG12_ATG7_TKT_LAMP2_SESN2 ATG7_TKT_FASLG_LAMP2_SESN2_SIRT1
CDH1_ID2_MMP9_TCF3_SESN2 TKT_CDH1_ID2_MMP9_TCF3_SESN2
七种的组合八种的组合
ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_FASLG_HMGB1_LAMP2_SESN2ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAGATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAGATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAGATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG3_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1ATG3_ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG3_ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1_UVRAGAKT1_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1ATG3_ATG5_FRAP1_LC3_ID2_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_CIAP2_FASLG_LAMP2_SESN2ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2ATG5_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAGAIFM1_ATG12_TKT_CDH1_FASLG_LAMP2_SESN2 ATG3_ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1_UVRAGATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3 AKT1_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1AKT1_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1 AIFM1_ATG12_NNMT_CDH2_CIAP2_FASLG_LAMP2_SESN2ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG3_ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SESN3_SIRT1ATG3_ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1_UVRAGATG3_ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_AGER_FASLG_LAMP2_SESN2ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1_UVRAGATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1_UVRAGATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1AIFM1_ATG12_TKT_CIAP2_FASLG_LAMP2_SESN2 ATG3_ATG5_ATG7_FRAP1_LAMP1_LC3_SESN2_SIRT1ATG5_CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1 AKT1_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1ATG7_TKT_FASLG_LAMP2_SESN2_SESN3_SIRT1 AIFM1_DRAM_TKT_CDH1_FASLG_LAMP2_SESN2_SIRT1ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SATB1_SESN2_SIRT1ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_ID2_SATB1_SESN2_SIRT1ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SESN3_SIRT1ATG12_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SESN3_SIRT1AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1ATG5_ATG7_FRAP1_LC3_RPS19BP1_SESN2_SIRT1ATG5_CSE1L_DRAM_FRAP1_LC3_SATB1_SESN2_SIRT1ATG3_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 AIFM1_DRAM_TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 ATG5_ATG7_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2 ATG3_ATG5_DIABLO_DRAM_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3 ATG5_ATG7_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1AKT1_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_MMP9_AGER_FASLG_LAMP2_SESN2_SIRT1AKT1_ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1ATG7_TKT_CDH1_ID2_MMP9_TCF3_SESN2 TKT_CDH1_ID2_MMP9_TCF3_FASLG_SESN2_SIRT1。
32.如权利要求23所述的方法，所述方法用于预测B组的复发预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表10]
一种两种的组合三种的组合四种的组合
HMGB1 ATG3_HMGB1 ATG3_BCL2_HMGB1 ATG3_BCL2_CDH1_HMGB1
TKT ATG3_BECN1 ATG3_HMGB1_RAGE ATG3_CDH1_HMGB1_UVRAG
TKT_HMGB1 ATG3_TKT_HMGB1 ATG3_BCL2_TKT_HMGB1
BCL2L1_TKT ATG3_CDH1_HMGB1 ATG3_BCL2_HMGB1_RAGE
ATG3_NAMPT ATG3_HMGB1_HMGB2 ATG3_BCL2_HMGB1_HMGB2
BCL2_HMGB1 ATG3_HMGB1_UVRAG ATG3_CDH1_HMGB1_SIRT1
HMGB1_TWIST1 ATG3_CASP3_HMGB1 ATG3_BCL2_HMGB1_MMP2
ATG12_ATG3 ATG3_HMGB1_SIRT1 ATG3_HMGB1_HMGB2_RAGE
CSE1L_DIABLO ATG3_BECN1_SATB1 ATG3_BCL2_BNIP3_HMGB1
ATG3_TKT ATG3_HMGB1_SATB1 ATG3_CDH1_CASP3_HMGB1
LAMP1_HMGB1 ATG3_LC3_BECN1 ATG3_CDH1_HMGB1_KIAA1967
TKT_BECN1 ATG3_HMGB1_LAMP2 ATG3_HMGB1_RAGE_UVRAG
CDH1_HMGB1 ATG3_HMGB1_RAPTOR ATG3_HMGB1_RAGE_SIRT1
HMGB1_TP63 ATG3_HMGB1_KIAA1967 ATG3_TKT_HMGB1_HMGB2
TKT_NAMPT BCL2L1_TKT_CASP3 ATG3_TKT_HMGB1_UVRAG
BCL2_TKT ATG12_ATG3_HMGB1 ATG3_BCL2_LAMP1_HMGB1
CSE1L_TKT BCL2L1_TKT_SIRT1 ATG3_BCL2_HMGB1_RAPTOR
LC3_TKT ATG3_CIAP2_HMGB1 AIFM1_ATG3_BCL2_HMGB1
TKT_CASP3 BCL2L1_TKT_BECN1 ATG3_CASP3_HMGB1_RAGE
FASLG_HMGB1 BCL2_TKT_HMGB1 ATG12_ATG3_HMGB1_RAGE
CDH2_HMGB1 ATG3_BECN1_SESN3 ATG3_TKT_CASP3_HMGB1
ATG5_HMGB1 ATG3_CASP8_HMGB1 ATG3_TKT_HMGB1_KIAA1967
HMGB1_SIRT1 ATG3_CDH2_HMGB1 ATG3_BCL2L1_TKT_BECN1
ATG12_HMGB1 ATG3_FRAP1_HMGB1 ATG12_ATG3_CDH1_HMGB1
HMGB1_RAGE ATG3_BNIP3_HMGB1 ATG3_CDH1_HMGB1_RAGE
HMGB1_UVRAG ATG3_BECN1_HMGB1 ATG3_BCL2_FRAP1_HMGB1
BCL2L1_SIRT1 ATG3_CBS_HMGB1 ATG3_BCL2_HMGB1_LAMP2
ATG3_TCF3 AIFM1_ATG3_HMGB1 ATG3_BCL2_DIABLO_HMGB1
BCL2L1_HMGB1 ATG3_HMGB1_STAT3 ATG3_TKT_HMGB1_SIRT1
TKT_SIRT1 ATG3_HMGB1_MMP2 ATG3_BCL2_CBS_HMGB1
HMGB1_LAMP2 ATG3_LAMP1_HMGB1 ATG3_BCL2_CASP8_HMGB1
TKT_SESN2 BCL2L1_TKT_FASLG ATG3_HMGB1_HMGB2_SATB1
HMGB1_MMP2 ATG3_DIABLO_HMGB1 ATG3_BCL2_PTEN_HMGB1
TKT_AGER BCL2_BCL2L1_TKT ATG3_HMGB1_RAGE_RAPTOR
HMGB1_RAPTOR TKT_HMGB1_TWIST1 ATG3_TKT_HMGB1_RAGE
E2F1_HMGB1 ATG3_NNMT_HMGB1 ATG3_BCL2_CASP3_HMGB1
CASP8_HMGB1 ATG3_MMP9_HMGB1 ATG3_BCL2_HMGB1_SATB1
TKT_ID2 BCL2L1_TKT_HMGB1 ATG3_HMGB1_LAMP2_RAGE
AKT1_TKT ATG3_LAMP1_BECN1 ATG3_CDH1_HMGB1_LAMP2
ATG3_SIRT1 ATG3_BCL2L1_BECN1 ATG3_HMGB1_HMGB2_UVRAG
TKT_RPS19BP1 ATG5_TKT_HMGB1 ATG3_BCL2L1_TKT_HMGB1
CSE1L_HMGB1 ATG3_FASLG_HMGB1 CDH1_HMGB1_TP63_UVRAG
BCL2L1_BECN1 ATG3_MMP9_BECN1 ATG3_CDH1_HMGB1_HMGB2
CASP3_HMGB1 ATG3_ATG7_BECN1 ATG3_BCL2L1_TKT_CASP3
ATG7_HMGB1 ATG3_HMGB1_SESN3 ATG3_HMGB1_KIAA1967_RAGE
FRAP1_HMGB1 ATG3_E2F1_HMGB1 ATG3_BCL2_DRAM_HMGB1
HMGB1_HMGB2 HMGB1_RAPTOR_TWIST1 ATG3_LC3_TKT_HMGB1
HMGB1_SATB1 AKT1_ATG3_BECN1 ATG3_BCL2_HMGB1_UVRAG
ATG3_ULK1 ATG3_FAS_HMGB1 ATG3_CDH1_CDH2_HMGB1
ATG3_SESN1 ATG3_ULK1_HMGB1 BCL2_BCL2L1_TKT_CASP3
CBS_HMGB1 TKT_HMGB1_SIRT1 ATG3_TKT_BECN1_HMGB1
TKT_KIAA1967 ATG3_BAX_HMGB1 ATG3_TKT_HMGB1_LAMP2
ATG12_BCL2L1 TKT_CDH2_HMGB1 ATG3_BCL2_PRKAA1_HMGB1
DRAM_HMGB1 ATG3_PTEN_HMGB1 BCL2L1_TKT_CASP3_SIRT1
LC3_FASLG ATG3_TKT_BECN1 BCL2L1_TKT_CASP3_FASLG
HMGB1_KIAA1967 ATG3_HMGB1_TWIST1 BCL2L1_TKT_CASP3_CDH2
TKT_SESN1 BCL2L1_TKT_UVRAG ATG3_BCL2_NNMT_HMGB1
五种的组合六种的组合
ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR
ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE
ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE
ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE
ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR
ATG3_BCL2_BNIP3_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE
ATG3_BCL2_CDH1_HMGB1_LAMP2 ATG3_BCL2_CDH1_HMGB1_RAGE_UVRAG
ATG3_BCL2_CDH1_CDH2_HMGB1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE
ATG3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_CASP3_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG
ATG12_ATG3_BCL2_CDH1_HMGB1 ATG12_ATG3_BCL2_CDH1_HMGB1_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_UVRAG
ATG3_BCL2_CASP8_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAGE
ATG3_BCL2_FRAP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2
ATG3_BCL2_CBS_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2
ATG3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1
ATG3_BCL2_TKT_HMGB1_HMGB2 AIFM1_ATG3_BCL2_CDH1_HMGB1_UVRAG
ATG3_BCL2_CDH1_HMGB1_MMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967
ATG3_BCL2_NNMT_CDH1_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2
ATG3_BCL2_HMGB1_HMGB2_RAGE ATG12_ATG3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_CDH1_MMP9_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAPTOR
ATG12_ATG3_CDH1_HMGB1_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_SIRT1
ATG3_CDH1_HMGB1_LAMP2_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2
ATG3_BCL2_DIABLO_CDH1_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE
ATG3_BCL2L1_TKT_BECN1_CASP3 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967
ATG3_BCL2_HMGB1_MMP2_RAGE ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE
ATG3_CDH1_HMGB1_HMGB2_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2
ATG3_BCL2_DRAM_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_SIRT1
ATG3_BCL2_TKT_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_UVRAG
ATG3_BCL2_TKT_CASP3_HMGB1 ATG3_BCL2_CASP8_CDH1_HMGB1_RAGE
ATG3_CDH1_HMGB1_KIAA1967_UVRAG ATG3_CDH1_HMGB1_LAMP2_RAGE_SIRT1
ATG3_CDH1_HMGB1_LAMP2_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_UVRAG
ATG3_BCL2_BCL2L1_TKT_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_SATB1 ATG3_BCL2_BCL2L1_TKT_HMGB1_SIRT1
ATG3_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_SIRT1
ATG3_BCL2_TKT_ID2_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_RAGE
ATG3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967
ATG3_BCL2_PTEN_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAPTOR
AIFM1_ATG3_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_RAGE_SIRT1_UVRAG
ATG3_BCL2_CDH1_HMGB1_STAT3 ATG3_BCL2_CBS_CDH1_HMGB1_RAGE
ATG3_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_UVRAG
ATG3_BCL2_LC3_TKT_HMGB1 ATG3_BCL2_CBS_CDH1_HMGB1_UVRAG
ATG3_CDH1_CASP3_HMGB1_UVRAG ATG3_CDH1_HMGB1_HMGB2_RAGE_SIRT1
ATG3_BCL2_CDH1_CIAP2_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAPTOR
ATG3_BCL2_BNIP3_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAPTOR
ATG3_CDH1_HMGB1_RAPTOR_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3
ATG3_CDH1_HMGB1_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_RAPTOR_UVRAG
ATG3_CDH1_HMGB1_RAPTOR_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2
ATG3_CDH1_HMGB1_KIAA1967_SIRT1 ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2
ATG3_BAX_BCL2_CDH1_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_SIRT1
ATG3_BCL2_LAMP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_SIRT1
ATG3_ATG5_BCL2_CDH1_HMGB1 AIFM1_ATG3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_TKT_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2
ATG3_CDH1_HMGB1_SATB1_UVRAG ATG3_BCL2_CBS_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_SESN3 ATG3_BCL2_CASP8_CDH1_HMGB1_UVRAG
ATG3_BCL2_FAS_CDH1_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_UVRAG
CDH1_ID2_MMP9_TCF3_FASLG ATG12_ATG3_CDH1_ID2_MMP9_TCF3
七种的组合八种的组合
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAGATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGEATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1 AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_KIAA1967_TWIST1ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGE ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGEATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_UVRAGATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967 ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_TWIST1ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_HMGB2_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAPTORATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGEATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGE ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_KIAA1967AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAGATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTORATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGEAIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAGATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_LAMP2ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_UVRAGATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_KIAA1967AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_LC3_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAGAIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_SIRT1ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_UVRAGATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTOR AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGE ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_UVRAG ATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1 ATG3_LC3_TKT_HMGB1_KIAA1967_RAGE_TWIST1_UVRAGATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_KIAA1967AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTORATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTORATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_UVRAGATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_UVRAGATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGE ATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGEATG12_ATG3_CDH1_ID2_MMP9_TCF3_SATB1 ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG。
33.如权利要求23所述的方法，所述方法用于预测B组的存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表11]
一种两种的组合三种的组合四种的组合
ATG12 DIABLO_NAMPT DIABLO_ID2_NAMPT ATG12_ID2_MMP9_TCF3
DIABLO ATG12_ID2 DIABLO_FAS_NAMPT DIABLO_FAS_ID2_NAMPT
UVRAG ATG12_RPS19BP1 ATG12_ID2_TCF3 ATG12_CSE1L_ID2_MMP9
NAMPT ATG12_DIABLO DIABLO_FAS_STAT3 DIABLO_ID2_MMP9_NAMPT
STAT3 ID2_NAMPT ATG12_ID2_MMP9 DIABLO_FAS_MMP9_NAMPT
E2F1 DIABLO_STAT3 ATG12_ID2_SATB1 DIABLO_ID2_NAMPT_STAT3
BECN1 DIABLO_FAS ATG12_ID2_RPS19BP1 ATG12_FAS_ID2_MMP9
FRAP1 ATG12_CSE1L ATG12_CSE1L_ID2 ATG12_ID2_MMP9_SATB1
ATG7 ATG12_MMP9 ATG12_DIABLO_FAS DIABLO_ID2_NAMPT_SATB1
ID2 ATG12_ATG3 ATG12_ID2_SESN2 ATG12_ID2_MMP9_SESN2
SIRT1 ATG12_SATB1 ATG12_ID2_NAMPT ATG12_ID2_MMP9_RPS19BP1
BCL2 ATG12_SESN2 ATG12_CSE1L_DIABLO CSE1L_DIABLO_ID2_NAMPT
BNIP3 CSE1L_DIABLO ID2_NAMPT_STAT3 DIABLO_ID2_TCF3_NAMPT
LAMP2 ATG12_TCF3 ATG12_ID2_BHLHE41 DIABLO_FAS_NAMPT_SATB1
TKT ATG12_FAS CSE1L_DIABLO_NAMPT ATG12_DIABLO_FAS_MMP9
ATG12_STAT3 DIABLO_LC3_NAMPT DIABLO_FAS_ID2_STAT3
ATG12_BHLHE41 ATG12_FAS_ID2 ATG12_ATG3_ID2_TCF3
ATG12_NAMPT ID2_NAMPT_RPS19BP1 ATG3_DIABLO_ID2_NAMPT
ATG12_ATG7 ID2_MMP9_TCF3 ATG12_ID2_TCF3_STAT3
ID2_BECN1 DIABLO_NAMPT_SATB1 DIABLO_FAS_NAMPT_STAT3
E2F1_FAS ATG12_CSE1L_MMP9 ATG12_CSE1L_DIABLO_MMP9
ATG12_ATG5 ATG12_MMP9_RPS19BP1 ATG12_ID2_TCF3_SATB1
ID2_STAT3 ID2_MMP9_BECN1 DIABLO_FAS_MMP9_STAT3
ATG12_ULK1 DIABLO_NAMPT_STAT3 ATG12_ID2_MMP9_BHLHE41
DIABLO_BECN1 ATG12_DIABLO_MMP9 ATG12_BNIP3_ID2_MMP9
ATG12_LAMP1 ATG12_FAS_RPS19BP1 DIABLO_FAS_SATB1_STAT3
ATG12_LC3 DIABLO_FAS_MMP9 DIABLO_FAS_NAMPT_RPS19BP1
DIABLO_TCF3 ID2_MMP9_NAMPT ATG12_ATG3_ID2_MMP9
AKT1_ATG12 ATG12_ID2_STAT3 ATG12_ID2_MMP9_NAMPT
ATG12_FRAP1 ATG12_DIABLO_TCF3 DIABLO_FAS_NAMPT_SESN2
DIABLO_ID2 ATG12_ATG3_ID2 DIABLO_ID2_NAMPT_SESN2
ID2_TCF3 ATG12_DIABLO_ID2 ATG12_ID2_TCF3_RPS19BP1
DIABLO_SATB1 CSE1L_DIABLO_STAT3 ATG12_DIABLO_MMP9_TCF3
ATG12_BECN1 DIABLO_ID2_STAT3 ATG12_CSE1L_ID2_SATB1
ATG12_SIRT1 ATG12_ATG3_RPS19BP1 ATG12_FAS_MMP9_RPS19BP1
NAMPT_STAT3 ATG12_DIABLO_SATB1 ID2_MMP9_TCF3_STAT3
ATG12_BNIP3 ATG12_MMP9_TCF3 ATG12_DIABLO_ID2_NAMPT
DIABLO_MMP9 ATG3_DIABLO_NAMPT DIABLO_ID2_TCF3_STAT3
ATG12_UVRAG ATG12_DIABLO_NAMPT ATG12_ULK1_ID2_TCF3
DIABLO_FRAP1 ATG12_CSE1L_RPS19BP1 ATG12_ID2_TCF3_SESN2
NAMPT_RPS19BP1 DIABLO_MMP9_NAMPT BNIP3_CSE1L_DIABLO_MMP9
AKT1_NAMPT ATG12_ATG3_DIABLO ATG12_DIABLO_ID2_TCF3
E2F1_UVRAG DIABLO_SATB1_STAT3 ATG12_ATG5_ID2_MMP9
ATG3_DIABLO ID2_TCF3_STAT3 ATG12_ID2_SATB1_STAT3
NAMPT_UVRAG ATG12_RPS19BP1_SATB1 ATG12_MMP9_TCF3_RPS19BP1
BNIP3_DIABLO ATG12_DIABLO_STAT3 ATG12_DIABLO_FAS_ID2
DIABLO_LC3 ATG12_TCF3_RPS19BP1 ATG12_CSE1L_ID2_SESN2
DIABLO_SIRT1 DIABLO_NAMPT_SESN2 DIABLO_FAS_MMP9_TCF3
LC3_NAMPT ATG12_DIABLO_SESN2 ATG12_ID2_TCF3_BHLHE41
DIABLO_SESN2 ATG12_ULK1_ID2 ATG12_FAS_ID2_STAT3
FAS_STAT3 ATG12_ATG5_ID2 BNIP3_CSE1L_ID2_MMP9
FAS_NAMPT AKT1_DIABLO_NAMPT CSE1L_DIABLO_FAS_NAMPT
E2F1_NAMPT ATG12_ID2_BECN1 ATG12_CSE1L_ID2_TCF3
ATG12_SESN3 ATG12_FAS_MMP9 ATG12_ID2_NAMPT_RPS19BP1
BCL2_TKT ATG12_DIABLO_BHLHE41 ATG12_ID2_MMP9_BECN1
ATG7_NAMPT ATG12_RPS19BP1_STAT3 DIABLO_FAS_LC3_NAMPT
ATG7_BECN1 DIABLO_NAMPT_RPS19BP1 FAS_ID2_NAMPT_RPS19BP1
CDH1_ID2_MMP9_TCF3
五种的组合六种的组合
DIABLO_FAS_ID2_MMP9_NAMPT DIABLO_FAS_ID2_MMP9_TCF3_NAMPT
ATG12_ATG3_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3
ATG12_ID2_MMP9_TCF3_SATB1 ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1
ATG12_CSE1L_ID2_MMP9_TCF3 ATG12_ATG3_ID2_MMP9_TCF3_SATB1
ATG12_BNIP3_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_SATB1
ATG12_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ULK1_ID2_MMP9_TCF3
ATG12_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_CSE1L_ID2_MMP9_SESN2
ATG12_ATG5_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_STAT3
ATG12_FAS_ID2_MMP9_TCF3 ATG12_ATG3_FAS_ID2_MMP9_TCF3
DIABLO_FAS_ID2_NAMPT_STAT3 ATG12_ATG3_ID2_MMP9_TCF3_SESN2
ATG12_ID2_MMP9_TCF3_RPS19BP1 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3
ATG12_BNIP3_ID2_MMP9_RPS19BP1 CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT
ATG12_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_CSE1L_ID2_MMP9_TCF3
ATG12_CSE1L_ID2_MMP9_SESN2 ATG12_BNIP3_ID2_MMP9_TCF3_SATB1
ATG12_LAMP1_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_SESN2
DIABLO_FAS_ID2_NAMPT_SATB1 ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41
ATG12_BNIP3_CSE1L_ID2_MMP9 ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1
DIABLO_ID2_MMP9_TCF3_NAMPT DIABLO_FAS_ID2_MMP9_TCF3_STAT3
ATG12_BNIP3_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9
ATG12_ID2_MMP9_TCF3_BHLHE41 ATG12_ATG3_BNIP3_ID2_MMP9_SATB1
ATG12_ID2_MMP9_TCF3_STAT3 ATG12_BNIP3_CSE1L_ID2_MMP9_RPS19BP1
ATG12_BNIP3_FAS_ID2_MMP9 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9
ATG12_BNIP3_ID2_MMP9_SESN2 ATG12_BNIP3_FAS_ID2_MMP9_RPS19BP1
ATG12_ATG3_FAS_ID2_MMP9 ATG12_CSE1L_ID2_MMP9_TCF3_SATB1
CSE1L_DIABLO_ID2_MMP9_NAMPT ATG12_CSE1L_ULK1_ID2_MMP9_TCF3
ATG12_DIABLO_ID2_MMP9_TCF3 ATG12_FAS_ID2_MMP9_TCF3_RPS19BP1
DIABLO_ID2_NAMPT_SATB1_STAT3 DIABLO_FAS_ID2_NAMPT_SATB1_STAT3
ATG12_ATG3_CSE1L_ID2_MMP9 ATG12_ATG5_BNIP3_ID2_MMP9_TCF3
ATG12_FAS_ID2_MMP9_RPS19BP1 ATG12_BNIP3_ID2_MMP9_TCF3_SESN2
ATG12_DIABLO_FAS_ID2_MMP9 ATG12_CSE1L_ID2_MMP9_TCF3_SESN2
DIABLO_FAS_ID2_MMP9_STAT3 ATG12_ID2_MMP9_TCF3_SATB1_SESN2
ATG12_CSE1L_ID2_MMP9_BHLHE41 ATG12_ULK1_ID2_MMP9_TCF3_SATB1
DIABLO_ID2_MMP9_NAMPT_STAT3 ATG12_ATG3_ATG5_ID2_MMP9_TCF3
DIABLO_FAS_ID2_NAMPT_SESN2 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9
ATG12_CSE1L_FAS_ID2_MMP9 ATG12_ATG3_LAMP1_ID2_MMP9_TCF3
DIABLO_FAS_ID2_TCF3_NAMPT ATG12_BNIP3_DIABLO_ID2_MMP9_TCF3
ATG12_ATG3_ID2_MMP9_SATB1 ATG12_BNIP3_ULK1_ID2_MMP9_TCF3
ATG12_BNIP3_ID2_MMP9_BHLHE41 ATG12_DIABLO_FAS_ID2_MMP9_TCF3
ATG3_DIABLO_FAS_ID2_NAMPT ATG12_ULK1_ID2_MMP9_TCF3_SESN2
CSE1L_DIABLO_FAS_ID2_NAMPT ATG3_DIABLO_FAS_ID2_MMP9_NAMPT
ATG12_CSE1L_ID2_MMP9_RPS19BP1 ATG12_ATG3_BNIP3_ID2_MMP9_SESN2
ATG12_CSE1L_ULK1_ID2_MMP9 ATG12_ATG3_ID2_MMP9_TCF3_BHLHE41
DIABLO_FAS_ID2_MMP9_TCF3 ATG12_BNIP3_CSE1L_FAS_ID2_MMP9
CSE1L_DIABLO_ID2_NAMPT_STAT3 DIABLO_ID2_MMP9_TCF3_NAMPT_SATB1
ATG12_ATG3_ID2_MMP9_SESN2 ATG12_ATG3_BNIP3_ID2_MMP9_RPS19BP1
DIABLO_ID2_MMP9_TCF3_STAT3 ATG12_ATG5_ID2_MMP9_TCF3_SATB1
DIABLO_ID2_TCF3_NAMPT_SATB1 ATG12_BNIP3_FAS_ID2_MMP9_TCF3
CSE1L_DIABLO_FAS_MMP9_NAMPT ATG12_ATG3_CSE1L_ID2_MMP9_SATB1
DIABLO_FAS_ID2_NAMPT_RPS19BP1 ATG12_ATG3_ID2_MMP9_TCF3_STAT3
BNIP3_DIABLO_FAS_ID2_MMP9 ATG12_ATG5_BNIP3_ID2_MMP9_SATB1
DIABLO_ID2_MMP9_NAMPT_SATB1 ATG12_BNIP3_ID2_MMP9_TCF3_BHLHE41
ATG12_DIABLO_FAS_MMP9_TCF3 ATG12_FAS_ID2_MMP9_TCF3_SESN2
ATG12_ATG5_FAS_ID2_MMP9 DIABLO_FAS_ID2_MMP9_NAMPT_RPS19BP1
ATG12_LC3_ID2_MMP9_TCF3 ATG12_ATG3_CSE1L_ID2_MMP9_SESN2
ATG12_FAS_ID2_MMP9_STAT3 ATG12_ATG3_ID2_MMP9_TCF3_RPS19BP1
FAS_ID2_MMP9_NAMPT_RPS19BP1 ATG12_ATG5_BNIP3_FAS_ID2_MMP9
ATG12_ID2_MMP9_TCF3_BECN1 ATG12_ATG5_ULK1_ID2_MMP9_TCF3
ATG12_CDH1_ID2_MMP9_TCF3 E2F1_FAS_CDH1_ID2_MMP9_TCF3
七种的组合八种的组合
DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SESN2 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_STAT3DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_SESN2ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_SESN2ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_STAT3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_STAT3 ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3 ATG3_BCL2_E2F1_LAMP1_TKT_MMP9_CASP3_HMGB1ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_CSE1L_DIABLO_FAS_ID2_MMP9ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_BHLHE41ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_SATB1ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_SATB1ATG12_ATG3_ID2_MMP9_TCF3_SATB1_SESN2 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_SESN2DIABLO_FAS_ID2_MMP9_TCF3_SATB1_STAT3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41_SATB1ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9 ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_SESN2ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1_SESN2ATG12_BNIP3_CSE1L_DIABLO_FAS_ID2_MMP9 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_SATB1ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SESN2 ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_SATB1CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_STAT3 ATG12_BNIP3_FAS_ULK1_ID2_MMP9_TCF3_RPS19BP1ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9 CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_STAT3ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_TCF3ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_SESN2ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2 ATG12_ATG3_ATG5_BNIP3_ULK1_ID2_MMP9_TCF3ATG12_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_RPS19BP1ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_SATB1ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SESN2ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1 ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_SATB1ATG12_ATG3_FAS_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_SESN2ATG12_ATG3_FAS_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_RPS19BP1ATG12_ATG3_FAS_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_TCF3ATG12_ATG3_FAS_ULK1_ID2_MMP9_TCF3 ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_SATB1 ATG12_ATG5_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_RPS19BP1 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1_SESN2ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SESN2 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3_SATB1ATG12_ATG3_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_SESN2ATG12_BNIP3_CSE1L_FAS_ID2_MMP9_RPS19BP1 ATG12_BNIP3_DIABLO_FAS_ULK1_ID2_MMP9_TCF3ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1 ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_SESN2ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41 ATG3_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1ATG12_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2_STAT3ATG12_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1 DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2_STAT3DIABLO_FAS_ID2_MMP9_NAMPT_SESN2_STAT3 ATG12_ATG3_ATG5_BNIP3_CSE1L_FAS_ID2_MMP9CSE1L_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_BHLHE41DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_TCF3CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_RPS19BP1ATG12_ATG3_BNIP3_DIABLO_ID2_MMP9_TCF3 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_FAS_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_SESN2ATG3_TKT_CDH1_ID2_MMP9_TCF3_UVRAG ATG3_TKT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG。
34.如权利要求23所述的方法，所述方法用于预测B组的无病存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表12]
一种两种的组合三种的组合四种的组合
DIABLO ATG3_BECN1 ATG3_BCL2_HMGB1 ATG3_BCL2_CDH1_HMGB1
BECN1 ATG3_HMGB1 ATG3_HMGB1_RAGE ATG3_CDH1_HMGB1_UVRAG
HMGB1 BCL2L1_TKT ATG3_HMGB1_UVRAG ATG3_BCL2_TKT_HMGB1
CSE1L_DIABLO ATG3_CASP3_HMGB1 ATG3_BCL2_HMGB1_RAGE
BCL2_HMGB1 ATG3_HMGB1_SIRT1 ATG3_BCL2_HMGB1_HMGB2
ATG12_ATG3 ATG3_BECN1_SATB1 ATG3_CDH1_HMGB1_SIRT1
ATG3_NAMPT ATG3_HMGB1_LAMP2 ATG3_BCL2_HMGB1_MMP2
HMGB1_TWIST1 ATG3_HMGB1_RAPTOR ATG3_HMGB1_HMGB2_RAGE
TKT_HMGB1 ATG3_LC3_BECN1 ATG3_BCL2_BNIP3_HMGB1
LAMP1_HMGB1 ATG3_HMGB1_KIAA1967 ATG3_CDH1_CASP3_HMGB1
TKT_BECN1 BCL2L1_TKT_CASP3 ATG3_CDH1_HMGB1_KIAA1967
HMGB1_TP63 ATG12_ATG3_HMGB1 ATG3_HMGB1_RAGE_UVRAG
BCL2_TKT BCL2L1_TKT_SIRT1 ATG3_HMGB1_RAGE_SIRT1
TKT_CASP3 BCL2L1_TKT_BECN1 ATG3_TKT_HMGB1_UVRAG
FASLG_HMGB1 BCL2_TKT_HMGB1 ATG3_BCL2_LAMP1_HMGB1
TKT_NAMPT ATG3_BECN1_SESN3 ATG3_BCL2_HMGB1_RAPTOR
ATG5_HMGB1 ATG3_BNIP3_HMGB1 AIFM1_ATG3_BCL2_HMGB1
HMGB1_SIRT1 ATG3_BECN1_HMGB1 ATG3_CASP3_HMGB1_RAGE
ATG12_HMGB1 AIFM1_ATG3_HMGB1 ATG12_ATG3_HMGB1_RAGE
HMGB1_RAGE ATG3_LAMP1_HMGB1 ATG3_TKT_CASP3_HMGB1
DIABLO_NAMPT BCL2L1_TKT_FASLG ATG3_TKT_HMGB1_KIAA1967
HMGB1_UVRAG BCL2_BCL2L1_TKT ATG3_BCL2L1_TKT_BECN1
DIABLO_BECN1 TKT_HMGB1_TWIST1 ATG12_ATG3_CDH1_HMGB1
BECN1_SATB1 ATG3_NNMT_HMGB1 ATG3_CDH1_HMGB1_RAGE
BCL2L1_SIRT1 BCL2L1_TKT_HMGB1 ATG3_BCL2_FRAP1_HMGB1
BCL2L1_HMGB1 ATG3_BCL2L1_BECN1 ATG3_BCL2_HMGB1_LAMP2
TKT_SIRT1 ATG5_TKT_HMGB1 ATG3_BCL2_DIABLO_HMGB1
DIABLO_TCF3 ATG3_FASLG_HMGB1 ATG3_TKT_HMGB1_SIRT1
HMGB1_LAMP2 ATG3_MMP9_BECN1 ATG3_BCL2_CBS_HMGB1
DIABLO_SATB1 ATG3_LAMP1_BECN1 ATG3_BCL2_CASP8_HMGB1
HMGB1_RAPTOR ATG3_E2F1_HMGB1 ATG3_BCL2_PTEN_HMGB1
E2F1_HMGB1 HMGB1_RAPTOR_TWIST1 ATG3_HMGB1_RAGE_RAPTOR
ATG5_BECN1 AKT1_ATG3_BECN1 ATG3_TKT_HMGB1_RAGE
ATG12_SATB1 ATG3_ULK1_HMGB1 ATG3_BCL2_CASP3_HMGB1
BCL2L1_BECN1 TKT_HMGB1_SIRT1 ATG3_BCL2_HMGB1_SATB1
CASP3_HMGB1 ATG3_BAX_HMGB1 ATG3_HMGB1_LAMP2_RAGE
ATG12_CSE1L ATG3_PTEN_HMGB1 ATG3_CDH1_HMGB1_LAMP2
ATG7_HMGB1 ATG3_TKT_HMGB1 ATG3_HMGB1_HMGB2_UVRAG
ATG3_SIRT1 ATG3_TKT_BECN1 ATG3_BCL2L1_TKT_HMGB1
CASP8_HMGB1 ATG3_HMGB1_TWIST1 CDH1_HMGB1_TP63_UVRAG
ATG3_SESN1 BCL2L1_TKT_UVRAG ATG3_BCL2L1_TKT_CASP3
TKT_KIAA1967 TKT_HMGB1_UVRAG ATG3_HMGB1_KIAA1967_RAGE
ATG12_BCL2L1 BCL2L1_TKT_CDH2 ATG3_BCL2_DRAM_HMGB1
DRAM_HMGB1 BCL2L1_TKT_KIAA1967 ATG3_BCL2_HMGB1_UVRAG
LC3_FASLG ATG3_BCL2L1_HMGB1 BCL2_BCL2L1_TKT_CASP3
HMGB1_KIAA1967 ATG3_ATG5_HMGB1 ATG3_TKT_BECN1_HMGB1
TKT_SESN1 ATG3_DRAM_HMGB1 ATG3_TKT_HMGB1_LAMP2
ATG3_DIABLO ATG3_HMGB1_SATB1 ATG3_BCL2_PRKAA1_HMGB1
DIABLO_SIRT1 ATG3_BCL2L1_TKT BCL2L1_TKT_CASP3_SIRT1
BECN1_HMGB1 ATG3_PRKAA1_HMGB1 BCL2L1_TKT_CASP3_FASLG
AIFM1_HMGB1 TKT_CASP3_HMGB1 BCL2L1_TKT_CASP3_CDH2
ID2_BECN1 ATG3_XIAP_HMGB1 ATG3_BCL2_NNMT_HMGB1
CSE1L_BECN1 TKT_HMGB1_KIAA1967 ATG3_CDH1_HMGB1_RAPTOR
TKT_ULK1 TKT_HMGB1_LAMP2 ATG3_BNIP3_HMGB1_RAGE
BNIP3_HMGB1 HMGB1_RAGE_TWIST1 ATG3_BAX_BCL2_HMGB1
TKT_UVRAG ATG12_BCL2L1_TKT ATG3_BCL2_ID2_HMGB1
ATG5_TKT ATG3_PTEN_BECN1 ATG3_BCL2_HMGB1_STAT3
五种的组合六种的组合
ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR
ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE
ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE
ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE
ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR
ATG3_BCL2_BNIP3_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE
ATG3_BCL2_CDH1_HMGB1_LAMP2 ATG3_BCL2_CDH1_HMGB1_RAGE_UVRAG
ATG3_BCL2_CDH1_CDH2_HMGB1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE
ATG3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_CASP3_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG
ATG12_ATG3_BCL2_CDH1_HMGB1 ATG12_ATG3_BCL2_CDH1_HMGB1_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_UVRAG
ATG3_BCL2_CASP8_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAGE
ATG3_BCL2_FRAP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2
ATG3_BCL2_CBS_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2
ATG3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1
ATG3_BCL2_TKT_HMGB1_HMGB2 AIFM1_ATG3_BCL2_CDH1_HMGB1_UVRAG
ATG3_BCL2_CDH1_HMGB1_MMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967
ATG3_BCL2_NNMT_CDH1_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2
ATG3_BCL2_HMGB1_HMGB2_RAGE ATG12_ATG3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_CDH1_MMP9_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAPTOR
ATG12_ATG3_CDH1_HMGB1_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_SIRT1
ATG3_CDH1_HMGB1_LAMP2_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2
ATG3_BCL2_DIABLO_CDH1_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE
ATG3_BCL2L1_TKT_BECN1_CASP3 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967
ATG3_BCL2_HMGB1_MMP2_RAGE ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE
ATG3_CDH1_HMGB1_HMGB2_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2
ATG3_BCL2_DRAM_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_SIRT1
ATG3_BCL2_TKT_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_UVRAG
ATG3_BCL2_TKT_CASP3_HMGB1 ATG3_BCL2_CASP8_CDH1_HMGB1_RAGE
ATG3_CDH1_HMGB1_KIAA1967_UVRAG ATG3_CDH1_HMGB1_LAMP2_RAGE_SIRT1
ATG3_CDH1_HMGB1_LAMP2_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_UVRAG
ATG3_BCL2_BCL2L1_TKT_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_SATB1 ATG3_BCL2_BCL2L1_TKT_HMGB1_SIRT1
ATG3_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_SIRT1
ATG3_BCL2_TKT_ID2_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_RAGE
ATG3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967
ATG3_BCL2_PTEN_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAPTOR
AIFM1_ATG3_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_RAGE_SIRT1_UVRAG
ATG3_BCL2_CDH1_HMGB1_STAT3 ATG3_BCL2_CBS_CDH1_HMGB1_RAGE
ATG3_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_UVRAG
ATG3_BCL2_LC3_TKT_HMGB1 ATG3_BCL2_CBS_CDH1_HMGB1_UVRAG
ATG3_CDH1_CASP3_HMGB1_UVRAG ATG3_CDH1_HMGB1_HMGB2_RAGE_SIRT1
ATG3_BCL2_CDH1_CIAP2_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAPTOR
ATG3_BCL2_BNIP3_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAPTOR
ATG3_CDH1_HMGB1_RAPTOR_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3
ATG3_CDH1_HMGB1_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_RAPTOR_UVRAG
ATG3_CDH1_HMGB1_RAPTOR_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2
ATG3_CDH1_HMGB1_KIAA1967_SIRT1 ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2
ATG3_BAX_BCL2_CDH1_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_SIRT1
ATG3_BCL2_LAMP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_SIRT1
ATG3_ATG5_BCL2_CDH1_HMGB1 AIFM1_ATG3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_TKT_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2
ATG3_CDH1_HMGB1_SATB1_UVRAG ATG3_BCL2_CBS_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_SESN3 ATG3_BCL2_CASP8_CDH1_HMGB1_UVRAG
ATG3_BCL2_FAS_CDH1_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_UVRAG
CDH1_ID2_MMP9_TCF3_FASLG ATG12_ATG3_CDH1_ID2_MMP9_TCF3
七种的组合八种的组合
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAGATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGEATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1 AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_KIAA1967_TWIST1ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGE ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGEATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_UVRAGATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967 ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_TWIST1ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_HMGB2_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAPTORATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGEATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGE ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_KIAA1967AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAGATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTORATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGEAIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAGATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_LAMP2ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_UVRAGATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_KIAA1967AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_LC3_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAGAIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_SIRT1ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_UVRAGATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTOR AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGE ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_UVRAG ATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1 ATG3_LC3_TKT_HMGB1_KIAA1967_RAGE_TWIST1_UVRAGATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_KIAA1967AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTORATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTORATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_UVRAGATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_UVRAGATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGE ATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGENNMT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG。
35.如权利要求23所述的方法，所述方法用于预测C组的复发预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表13]
一种两种的组合三种的组合四种的组合
FASLG CIAP2_FASLG FAS_LC3_FASLG DIABLO_FAS_LC3_FASLG
CIAP2 E2F1_FASLG DIABLO_FAS_FASLG FAS_LC3_FASLG_UVRAG
CSE1L LC3_FASLG E2F1_LC3_FASLG BNIP3_FAS_LC3_FASLG
FAS DIABLO_FASLG FAS_FASLG_RPS19BP1 DRAM_FAS_LC3_FASLG
TCF3 FAS_FASLG E2F1_FAS_FASLG E2F1_FAS_LC3_FASLG
FASLG_RPS19BP1 FAS_FASLG_UVRAG ATG3_FAS_LC3_FASLG
PTEN_FASLG DIABLO_LC3_FASLG ATG7_FAS_LC3_FASLG
CASP3_FASLG ATG7_FAS_FASLG FAS_LC3_FASLG_STAT3
FASLG_SESN2 CIAP2_FASLG_SESN3 FAS_FRAP1_LC3_FASLG
FASLG_HMGB1 CIAP2_FASLG_UVRAG FAS_LC3_FASLG_SESN3
CDH2_FASLG BNIP3_LC3_FASLG FAS_LC3_FASLG_SIRT1
FRAP1_FASLG LC3_CIAP2_FASLG FAS_LC3_BECN1_FASLG
ATG7_FASLG LC3_FASLG_SESN2 ATG5_FAS_LC3_FASLG
ATG3_FAS FRAP1_LC3_FASLG FAS_LC3_FASLG_RPS19BP1
FASLG_HMGB2 LC3_FASLG_SESN3 FAS_LAMP1_LC3_FASLG
FASLG_UVRAG ATG3_FAS_FASLG FAS_LC3_FASLG_NAMPT
DIABLO_FAS ATG7_LC3_FASLG AKT1_FAS_LC3_FASLG
FASLG_MMP2 FAS_FRAP1_FASLG FAS_LC3_FASLG_SESN2
TKT_FASLG DIABLO_FASLG_SESN2 FAS_LC3_MMP9_FASLG
PTEN_CIAP2 DRAM_LC3_FASLG FAS_FASLG_RPS19BP1_SESN3
FAS_LC3 CIAP2_FASLG_HMGB1 FAS_FASLG_RPS19BP1_UVRAG
CBS_FASLG FAS_FASLG_SESN3 FAS_LC3_CDH1_FASLG
AIFM1_FASLG LC3_FASLG_UVRAG ATG12_FAS_LC3_FASLG
CASP3_CIAP2 CASP3_CIAP2_FASLG DIABLO_FAS_FASLG_SESN3
FASLG_SESN3 FAS_FASLG_SESN2 DIABLO_FAS_FASLG_UVRAG
ATG3_FASLG PTEN_CIAP2_FASLG FAS_LC3_FASLG_LAMP2
CASP8_FASLG DIABLO_FASLG_SESN3 FAS_LC3_ID2_FASLG
XIAP_FASLG ATG7_CIAP2_FASLG DIABLO_FAS_FASLG_SESN2
AGER_FASLG LC3_FASLG_SIRT1 FAS_LC3_BHLHE41_FASLG
ATG3_ULK1 LC3_FASLG_RPS19BP1 DIABLO_DRAM_FAS_FASLG
BNIP3_FASLG FASLG_SESN2_SESN3 DIABLO_FAS_FASLG_STAT3
FAS_UVRAG DRAM_FAS_FASLG DRAM_FAS_FASLG_RPS19BP1
CIAP2_RAGE ID2_CIAP2_FASLG DIABLO_FAS_FRAP1_FASLG
ATG3_TCF3 FAS_FASLG_STAT3 FAS_FASLG_SESN2_UVRAG
FASLG_RAGE AKT1_CIAP2_FASLG ATG3_FAS_FASLG_SESN2
E2F1_CIAP2 DIABLO_FRAP1_FASLG ATG7_DIABLO_FAS_FASLG
FASLG_VEGF BNIP3_FAS_FASLG FAS_LC3_TCF3_FASLG
E2F1_FAS FAS_LAMP1_FASLG ATG7_FAS_FASLG_UVRAG
XIAP_CIAP2 TKT_CIAP2_FASLG DIABLO_FAS_FASLG_NAMPT
BCL2L1_FASLG ATG7_DIABLO_FASLG DIABLO_FAS_FASLG_SIRT1
BNIP3_FAS FRAP1_FASLG_SESN2 DIABLO_FAS_LAMP1_FASLG
FASLG_SESN1 E2F1_ULK1_FASLG FAS_FRAP1_FASLG_RPS19BP1
FASLG_KIAA1967 DRAM_CIAP2_FASLG CSE1L_FAS_LC3_FASLG
AIFM1_CIAP2 PTEN_CASP3_FASLG DIABLO_FAS_BECN1_FASLG
DRAM_FASLG LC3_FASLG_NAMPT E2F1_LC3_ID2_FASLG
ATG3_CIAP2 PTEN_CDH1_CIAP2 AKT1_DIABLO_FAS_FASLG
CSE1L_FASLG ATG12_CIAP2_FASLG ATG3_DIABLO_FAS_FASLG
FASLG_RAPTOR FASLG_RPS19BP1_SESN3 E2F1_FAS_FASLG_SESN3
TCF3_FASLG MMP9_CIAP2_FASLG ATG7_FAS_FASLG_SESN2
FASLG_STAT3 LAMP1_CIAP2_FASLG DIABLO_FAS_FASLG_RPS19BP1
ULK1_FASLG LC3_BECN1_FASLG DRAM_FAS_FASLG_UVRAG
PRKAA1_CIAP2 CDH1_CIAP2_FASLG LC3_MMP9_FASLG_SESN2
FASLG_SIRT1 BECN1_CIAP2_FASLG FAS_FASLG_SESN3_UVRAG
ATG12_FASLG CIAP2_FASLG_HMGB2 DIABLO_FAS_FASLG_LAMP2
LAMP1_FASLG E2F1_FASLG_LAMP2 DIABLO_FAS_ID2_FASLG
NNMT_FASLG CIAP2_FASLG_SIRT1 E2F1_LC3_FASLG_LAMP2
BCL2L1_CIAP2 PTEN_XIAP_FASLG E2F1_LC3_MMP9_FASLG
CDH1_ID2_MMP9_TCF3
五种的组合六种的组合
BNIP3_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_SESN2
DRAM_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_FASLG_SESN3
DIABLO_DRAM_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2
ATG3_FAS_LC3_FASLG_SESN3 ATG3_FAS_LC3_MMP9_FASLG_SESN3
BNIP3_FAS_LC3_FASLG_SESN3 ATG3_FAS_LC3_FASLG_SESN2_SESN3
BNIP3_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG
ATG3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_STAT3
BNIP3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_UVRAG
DRAM_FAS_LC3_FASLG_STAT3 BNIP3_DRAM_FAS_LC3_FASLG_SIRT1
DIABLO_FAS_LC3_BECN1_FASLG ATG3_DRAM_FAS_LC3_FASLG_SESN2
BNIP3_DIABLO_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_BECN1_FASLG
ATG7_DRAM_FAS_LC3_FASLG DRAM_FAS_LC3_ID2_FASLG_UVRAG
DIABLO_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_MMP9_FASLG_UVRAG
DRAM_FAS_LC3_FASLG_SIRT1 DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1
DRAM_E2F1_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_UVRAG
DRAM_FAS_LC3_FASLG_SESN3 DRAM_FAS_LC3_FASLG_SIRT1_UVRAG
DRAM_FAS_LC3_BECN1_FASLG DRAM_FAS_LC3_MMP9_FASLG_UVRAG
BNIP3_FAS_LC3_FASLG_STAT3 BNIP3_DRAM_FAS_LC3_ID2_FASLG
BNIP3_FAS_LC3_MMP9_FASLG ATG3_DRAM_FAS_LC3_FASLG_SESN3
DIABLO_FAS_LC3_ID2_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN3
DIABLO_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN2
ATG5_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_BECN1_FASLG_UVRAG
ATG5_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_FRAP1_LC3_FASLG
DIABLO_FAS_LC3_FASLG_SIRT1 BNIP3_FAS_LC3_FASLG_SESN3_SIRT1
FAS_LC3_FASLG_SIRT1_UVRAG DRAM_FAS_LC3_BHLHE41_FASLG_UVRAG
DRAM_FAS_FRAP1_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_LAMP2
DIABLO_FAS_LC3_FASLG_SESN3 AKT1_BNIP3_DRAM_FAS_LC3_FASLG
FAS_LC3_BECN1_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG
ATG3_FAS_LC3_MMP9_FASLG DRAM_FAS_LC3_FASLG_SESN3_SIRT1
BNIP3_FAS_LC3_FASLG_SIRT1 ATG3_DIABLO_FAS_LC3_MMP9_FASLG
BNIP3_FAS_FRAP1_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN3_STAT3
DIABLO_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_BECN1_FASLG_SESN2
DIABLO_FAS_LC3_FASLG_NAMPT BNIP3_FAS_LC3_FASLG_SESN2_SIRT1
FAS_LC3_MMP9_FASLG_RPS19BP1 DIABLO_DRAM_FAS_LC3_MMP9_FASLG
BNIP3_FAS_LC3_BECN1_FASLG BNIP3_FAS_LC3_BECN1_FASLG_SESN3
E2F1_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN2_UVRAG
FAS_LC3_MMP9_FASLG_UVRAG DRAM_FAS_LC3_FASLG_LAMP2_UVRAG
ATG3_DIABLO_FAS_LC3_FASLG ATG3_FAS_FRAP1_LC3_MMP9_FASLG
DIABLO_FAS_LC3_BHLHE41_FASLG DRAM_FAS_LC3_BECN1_FASLG_SESN3
FAS_LC3_ID2_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_BECN1_FASLG
DIABLO_FAS_LC3_FASLG_LAMP2 ATG3_DRAM_FAS_LC3_MMP9_FASLG
DRAM_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_CDH1_FASLG
DRAM_FAS_LAMP1_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN2_UVRAG
ATG3_FAS_FRAP1_LC3_FASLG BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG
FAS_LC3_FASLG_STAT3_UVRAG ATG5_DRAM_FAS_LC3_FASLG_SESN3
AKT1_BNIP3_FAS_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN3_STAT3
FAS_LC3_FASLG_SESN3_UVRAG BNIP3_FAS_LC3_FASLG_SESN2_STAT3
ATG3_DRAM_FAS_LC3_FASLG BNIP3_DIABLO_FAS_LC3_MMP9_FASLG
AKT1_DRAM_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_SESN2
FAS_LC3_FASLG_SESN2_UVRAG ATG5_FAS_LC3_MMP9_FASLG_UVRAG
FAS_LC3_BHLHE41_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_BHLHE41_FASLG
DRAM_FAS_LC3_FASLG_NAMPT DIABLO_DRAM_FAS_LC3_FASLG_STAT3
FAS_LC3_FASLG_LAMP2_UVRAG ATG3_DIABLO_FAS_LC3_FASLG_SESN3
ATG7_BNIP3_FAS_LC3_FASLG DRAM_FAS_LC3_TCF3_FASLG_UVRAG
AKT1_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1
E2F1_FAS_LC3_ID2_FASLG ATG5_DRAM_FAS_LC3_FASLG_STAT3
DRAM_FAS_LC3_CDH1_FASLG ATG7_DRAM_FAS_LC3_MMP9_FASLG
PTEN_CDH1_ID2_MMP9_TCF3 LC3_CDH1_ID2_MMP9_TCF3_FASLG
七种的组合八种的组合
ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3ATG3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN3 ATG3_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1 ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_FASLG_SESN3_SIRT1 ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN3BNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3 ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SIRT1 ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAGBNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3_SIRT1ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN3 ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAGATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_SESN2BNIP3_DRAM_FAS_LC3_FASLG_SESN3_STAT3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_SESN2ATG3_FAS_LC3_ID2_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_STAT3ATG3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN3ATG5_DRAM_FAS_LC3_MMP9_FASLG_UVRAG ATG3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2 ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAGATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2 ATG3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN3 ATG3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3ATG3_FAS_LC3_FASLG_SESN2_SESN3_SIRT1 AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2ATG3_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2 BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SIRT1BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN3 ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_FAS_LC3_BECN1_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2ATG7_BNIP3_DRAM_FAS_LC3_MMP9_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_STAT3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_STAT3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAGBNIP3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_STAT3ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN3BNIP3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 BNIP3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN3 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN3 ATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_BECN1_FASLGBNIP3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG BNIP3_CSE1L_DRAM_FAS_LC3_MMP9_FASLG_SESN3ATG3_FAS_LC3_FASLG_LAMP2_SESN2_SESN3 ATG3_DRAM_FAS_LC3_ULK1_MMP9_FASLG_SESN3BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3BNIP3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN3 ATG3_FAS_LC3_ULK1_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAGBNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3_SIRT1FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG ATG3_FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG
。
36.如权利要求23所述的方法，所述方法用于预测C组的存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表14]
一种两种的组合三种的组合四种的组合
CSE1L ID2_CIAP2 ID2_CIAP2_SESN2 AIFM1_ID2_CIAP2_SESN2
CIAP2 CASP3_CIAP2 ID2_CASP3_CIAP2 PTEN_ID2_CIAP2_SESN2
TCF3 ID2_TCF3 ULK1_ID2_HMGB2 DIABLO_ID2_CASP3_CIAP2
CDH2 DIABLO_CDH2 ULK1_ID2_HMGB1 DRAM_FRAP1_CIAP2_TP63
FASLG CSE1L_CDH2 DIABLO_ID2_CASP3 BAX_ID2_CIAP2_SESN2
BECN1 CSE1L_TCF3 ULK1_ID2_AGER ID2_CIAP2_SESN2_VEGF
CASP3 CSE1L_CASP3 ID2_CIAP2_RPS19BP1 DRAM_ID2_CIAP2_SESN2
CDH1 CSE1L_RPS19BP1 CASP8_ULK1_ID2 ID2_CIAP2_RPS19BP1_SESN2
CDH2_CIAP2 ID2_TCF3_CIAP2 CBS_ID2_CIAP2_SESN2
ULK1_ID2 FRAP1_ID2_CIAP2 ATG3_ID2_CIAP2_SESN2
CSE1L_ID2 AIFM1_CDH1_CIAP2 NNMT_ID2_CIAP2_SESN2
CDH1_CIAP2 PTEN_CDH1_CIAP2 DIABLO_ID2_CIAP2_SESN2
CSE1L_FASLG ULK1_ID2_CIAP2 PRKAA1_ID2_CIAP2_SESN2
NNMT_CIAP2 DIABLO_ID2_CDH2 FRAP1_ID2_CIAP2_SESN2
CSE1L_MMP9 CDH1_CIAP2_VEGF DIABLO_DRAM_ID2_CASP3
CSE1L_CDH1 CDH1_CCNG2_CIAP2 XIAP_ID2_CIAP2_SESN2
CIAP2_RPS19BP1 BAX_CDH1_CIAP2 ID2_CIAP2_RAGE_SESN2
ID2_CDH2 ATG3_ID2_TCF3 DRAM_CIAP2_SESN2_TP63
CDH2_RPS19BP1 ULK1_ID2_MMP2 BNIP3_ID2_CIAP2_SESN2
CSE1L_STAT3 CBS_ULK1_ID2 BCL2L1_ID2_CIAP2_SESN2
DIABLO_CASP3 DIABLO_ID2_CIAP2 AIFM1_DIABLO_CDH1_CIAP2
CDH1_TCF3 LC3_ID2_CIAP2 ID2_CCNG2_CIAP2_SESN2
CSE1L_SIRT1 PTEN_ULK1_ID2 LC3_ID2_CIAP2_SESN2
CIAP2_SESN2 BAX_ULK1_ID2 ID2_CASP3_CIAP2_RPS19BP1
AIFM1_CIAP2 DIABLO_PTEN_CDH1 AIFM1_CDH1_CIAP2_SESN2
DIABLO_KIAA1967 CDH1_CASP3_CIAP2 ATG3_ID2_TCF3_RPS19BP1
CSE1L_KIAA1967 ULK1_ID2_CDH2 DIABLO_FRAP1_ID2_CDH2
AKT1_CSE1L CDH1_CIAP2_RAGE E2F1_ID2_CIAP2_SESN2
CSE1L_SESN2 ID2_CDH2_CIAP2 ID2_CASP3_CIAP2_SESN2
FRAP1_CDH2 NNMT_ID2_CIAP2 DRAM_ID2_CIAP2_RPS19BP1
FRAP1_CIAP2 XIAP_CIAP2_SESN2 ID2_CIAP2_HMGB1_SESN2
TCF3_FASLG CSE1L_ID2_CASP3 PTEN_ID2_CASP3_CIAP2
FASLG_SESN2 CSE1L_FRAP1_CDH2 ATG3_ID2_MMP9_TCF3
CSE1L_DIABLO BCL2_ID2_SESN2 LAMP1_ID2_CIAP2_SESN2
CSE1L_SATB1 AIFM1_ULK1_ID2 AIFM1_ID2_CASP3_CIAP2
MMP9_TCF3 ULK1_ID2_RAGE ATG5_ID2_CIAP2_SESN2
ATG12_CSE1L DIABLO_CDH1_CCNG2 DIABLO_PTEN_CDH1_CIAP2
ATG7_CSE1L BAX_DIABLO_CDH1 LAMP1_ID2_CASP3_CIAP2
CSE1L_BECN1 CSE1L_ID2_CDH2 ID2_CIAP2_HMGB2_SESN2
XIAP_CIAP2 AIFM1_CIAP2_SESN2 BCL2L1_CSE1L_ID2_SESN2
CSE1L_FAS NNMT_CDH1_CIAP2 TKT_ID2_CIAP2_SESN2
TCF3_RPS19BP1 CBS_ID2_CIAP2 DIABLO_XIAP_ID2_SESN2
XIAP_SESN2 DIABLO_CDH1_VEGF FRAP1_LC3_ID2_CIAP2
CIAP2_KIAA1967 ID2_MMP9_TCF3 ATG7_ID2_CIAP2_SESN2
TKT_CIAP2 AIFM1_DIABLO_CDH1 ID2_AGER_CIAP2_SESN2
PRKAA1_CIAP2 PRKAA1_CIAP2_SESN2 CSE1L_ID2_CASP3_CIAP2
CDH2_FASLG CDH1_ID2_CIAP2 DRAM_CASP3_CIAP2_TP63
CSE1L_FRAP1 CSE1L_CASP3_CIAP2 PTEN_CDH1_ID2_CIAP2
CSE1L_CIAP2 ULK1_ID2_VEGF CDH1_ID2_CIAP2_RPS19BP1
CSE1L_ULK1 ID2_CIAP2_HMGB1 ATG3_ULK1_ID2_HMGB1
PTEN_CIAP2 BCL2L1_CDH1_CIAP2 FRAP1_ID2_CIAP2_RPS19BP1
BCL2L1_CIAP2 ID2_CIAP2_MMP2 DIABLO_PTEN_ID2_CASP3
CIAP2_VEGF CSE1L_ID2_CIAP2 ID2_CIAP2_SESN2_TP63
ATG3_TCF3 BCL2L1_CSE1L_CDH1 ID2_TCF3_CIAP2_SESN2
AKT1_TCF3 CSE1L_CDH1_CASP3 DIABLO_CDH1_CIAP2_VEGF
CSE1L_LC3 CSE1L_XIAP_SESN2 ATG3_ULK1_ID2_AGER
TKT CDH2 PRKAA1_CDH1_CIAP2 ID2_CIAP2_MMP2_SESN2
CDH1_ID2_MMP9_TCF3
五种的组合六种的组合
DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_TKT_CIAP2_TP63
AIFM1_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_TKT_CIAP2_SESN2_TP63
DRAM_FRAP1_CDH1_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_CIAP2_TP63
ATG12_DRAM_FRAP1_CIAP2_TP63 AIFM1_DRAM_ID2_CIAP2_SESN2_TP63
DRAM_FRAP1_XIAP_CIAP2_TP63 DRAM_TKT_ID2_CIAP2_SESN2_TP63
DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG3_DRAM_CIAP2_SESN2_TP63
AIFM1_CDH1_ID2_CIAP2_SESN2 DRAM_FRAP1_TKT_CDH1_CIAP2_TP63
AIFM1_DRAM_FRAP1_CIAP2_TP63 ATG3_DRAM_ID2_CIAP2_SESN2_TP63
DRAM_FRAP1_TKT_CIAP2_TP63 DRAM_PTEN_ID2_CIAP2_SESN2_TP63
PTEN_CDH1_ID2_CIAP2_SESN2 DRAM_FRAP1_TKT_XIAP_CIAP2_TP63
BAX_CDH1_ID2_CIAP2_SESN2 DRAM_E2F1_FRAP1_CDH1_CIAP2_TP63
DRAM_FRAP1_ID2_CIAP2_TP63 ATG3_DRAM_FRAP1_CDH1_CIAP2_TP63
DRAM_TKT_CASP3_CIAP2_TP63 ATG7_DRAM_ID2_CIAP2_SESN2_TP63
CDH1_ID2_CCNG2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_CDH1_CIAP2_TP63
AIFM1_PTEN_ID2_CIAP2_SESN2 ATG5_DRAM_ID2_CIAP2_SESN2_TP63
DIABLO_FRAP1_CDH1_ID2_CIAP2 AIFM1_DIABLO_CDH1_ID2_CIAP2_SESN2
AIFM1_CBS_ID2_CIAP2_SESN2 AIFM1_BNIP3_DRAM_CIAP2_SESN2_TP63
AIFM1_LAMP1_ID2_CIAP2_SESN2 BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63
DRAM_ID2_CASP3_CIAP2_TP63 DRAM_NNMT_ID2_CIAP2_SESN2_TP63
DIABLO_PTEN_CDH1_ID2_CIAP2 CASP8_DRAM_ID2_CIAP2_SESN2_TP63
CDH1_ID2_CIAP2_SESN2_VEGF DRAM_ID2_BHLHE41_CIAP2_SESN2_TP63
DIABLO_CDH1_ID2_CASP3_CIAP2 DRAM_FRAP1_CDH1_CIAP2_RPS19BP1_TP63
AIFM1_ATG3_ID2_CIAP2_SESN2 DRAM_LAMP1_ID2_CIAP2_SESN2_TP63
AIFM1_BNIP3_ID2_CIAP2_SESN2 DRAM_FRAP1_CDH1_ID2_CIAP2_TP63
AIFM1_DIABLO_CDH1_ID2_CIAP2 BNIP3_DRAM_ID2_CIAP2_SESN2_TP63
ATG3_DRAM_ID2_CIAP2_SESN2 DRAM_ID2_MMP9_CIAP2_SESN2_TP63
AIFM1_BAX_ID2_CIAP2_SESN2 AKT1_DRAM_ID2_CIAP2_SESN2_TP63
DRAM_E2F1_CASP3_CIAP2_TP63 DRAM_ID2_CIAP2_RAGE_SESN2_TP63
AIFM1_ID2_CIAP2_HMGB2_SESN2 ATG12_DRAM_FRAP1_XIAP_CIAP2_TP63
AIFM1_ID2_MMP9_CIAP2_SESN2 DRAM_PRKAA1_ID2_CIAP2_SESN2_TP63
DIABLO_CDH1_ID2_CIAP2_VEGF DRAM_XIAP_ID2_CIAP2_SESN2_TP63
DIABLO_DRAM_XIAP_ID2_SESN2 AIFM1_DRAM_PTEN_CIAP2_SESN2_TP63
AIFM1_ATG5_ID2_CIAP2_SESN2 ATG3_DRAM_FRAP1_CASP3_CIAP2_TP63
AIFM1_ID2_CIAP2_HMGB1_SESN2 CASP8_DRAM_FRAP1_CDH1_CIAP2_TP63
BAX_DIABLO_CDH1_ID2_CIAP2 AIFM1_ATG5_DRAM_CIAP2_SESN2_TP63
DRAM_FRAP1_NNMT_CIAP2_TP63 AIFM1_CASP8_DRAM_CIAP2_SESN2_TP63
FRAP1_CDH1_ID2_CIAP2_RPS19BP1 BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63
DRAM_XIAP_CIAP2_SESN2_TP63 CBS_DRAM_ID2_CIAP2_SESN2_TP63
AIFM1_DIABLO_ID2_CIAP2_SESN2 DRAM_FRAP1_NNMT_TKT_CIAP2_TP63
AIFM1_DRAM_ID2_CIAP2_SESN2 AIFM1_AKT1_DRAM_CIAP2_SESN2_TP63
AIFM1_ID2_CIAP2_SESN2_VEGF DRAM_FRAP1_PTEN_CDH1_CIAP2_TP63
AIFM1_TKT_ID2_CIAP2_SESN2 DIABLO_PTEN_CDH1_ID2_CIAP2_SESN2
ATG3_ID2_MMP9_TCF3_RPS19BP1 DRAM_ID2_CIAP2_SESN2_TP63_VEGF
ATG5_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_XIAP_CIAP2_SESN2_TP63
CBS_FRAP1_ID2_CIAP2_SESN2 BNIP3_DRAM_FRAP1_CDH1_CIAP2_TP63
AIFM1_DIABLO_ID2_CASP3_CIAP2 AIFM1_ATG7_DRAM_CIAP2_SESN2_TP63
AIFM1_NNMT_ID2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_NNMT_CIAP2_TP63
ATG3_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_MMP9_CIAP2_SESN2_TP63
ATG3_FRAP1_ID2_CIAP2_SESN2 AIFM1_DRAM_PRKAA1_CIAP2_SESN2_TP63
BAX_DIABLO_DRAM_ID2_CASP3 AIFM1_DRAM_CIAP2_RAGE_SESN2_TP63
LAMP1_PTEN_ID2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_XIAP_CIAP2_TP63
CDH1_ID2_CIAP2_RAGE_SESN2 AIFM1_DRAM_NNMT_CIAP2_SESN2_TP63
CBS_DIABLO_ID2_CIAP2_SESN2 DRAM_FRAP1_CDH1_CIAP2_TP63_VEGF
DIABLO_CDH1_ID2_CCNG2_CIAP2 AIFM1_DRAM_LAMP1_CIAP2_SESN2_TP63
DIABLO_LAMP1_ID2_CASP3_CIAP2 DIABLO_DRAM_FRAP1_XIAP_CASP3_HMGB2
AIFM1_DRAM_CASP3_CIAP2_TP63 DRAM_TKT_XIAP_CIAP2_SESN2_TP63
BCL2L1_DRAM_FRAP1_CIAP2_TP63 AIFM1_BCL2L1_DRAM_CIAP2_SESN2_TP63
CDH1_ID2_MMP9_TCF3_CIAP2 BAX_CDH1_ID2_MMP9_TCF3_CIAP2
七种的组合八种的组合
AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGFATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_PTEN_TKT_XIAP_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF AIFM1_ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_SATB1_TP63ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 AIFM1_AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63 ATG12_BCL2L1_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63 AIFM1_ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PTEN_MMP9_CIAP2_TP63AIFM1_BCL2L1_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_E2F1_FRAP1_TKT_MMP9_CIAP2_TP63AIFM1_ATG12_DRAM_FRAP1_PTEN_CIAP2_TP63 ATG12_BCL2L1_CBS_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63_VEGFAIFM1_DRAM_PTEN_ID2_CIAP2_SESN2_TP63 ATG12_DIABLO_DRAM_FRAP1_TKT_CDH1_CIAP2_TP63AIFM1_DRAM_TKT_MMP9_CIAP2_SESN2_TP63 AIFM1_ATG3_DRAM_ID2_MMP9_CIAP2_SESN2_TP63ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63 ATG12_CBS_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_LAMP1_TKT_XIAP_CIAP2_TP63ATG12_DRAM_E2F1_FRAP1_TKT_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_BHLHE41_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_HMGB1_TP63AIFM1_ATG12_DRAM_FRAP1_MMP9_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63AIFM1_ATG3_DRAM_ID2_CIAP2_SESN2_TP63 AIFM1_DRAM_PTEN_ID2_MMP9_CIAP2_SESN2_TP63AIFM1_ATG3_DRAM_MMP9_CIAP2_SESN2_TP63 ATG12_ATG7_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_CIAP2_HMGB1_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63_VEGFAIFM1_ATG12_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_BNIP3_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63AIFM1_DRAM_ID2_MMP9_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63AIFM1_DRAM_LAMP1_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63_VEGFDRAM_FRAP1_TKT_CASP3_CIAP2_HMGB2_TP63 ATG12_DRAM_FRAP1_LAMP1_PTEN_TKT_CIAP2_TP63AIFM1_AKT1_ATG12_DRAM_FRAP1_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63AIFM1_DRAM_PRKAA1_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_DRAM_TKT_CIAP2_RAGE_SESN2_TP63 AIFM1_ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_TP63AIFM1_DRAM_TKT_ID2_CIAP2_SESN2_TP63 ATG12_BCL2L1_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_CIAP2_SATB1_TP63 ATG12_CBS_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63AIFM1_AKT1_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_LAMP1_PRKAA1_TKT_CIAP2_TP63AIFM1_ATG12_DRAM_FRAP1_CIAP2_TP63_VEGF ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_RAGE_TP63AIFM1_ATG3_DRAM_NNMT_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63AIFM1_BAX_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_BCL2L1_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_DRAM_NNMT_ID2_CIAP2_SESN2_TP63 ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63_VEGFDRAM_FRAP1_NNMT_TKT_XIAP_CIAP2_TP63 AIFM1_ATG3_DRAM_NNMT_ID2_CIAP2_SESN2_TP63BCL2L1_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_DRAM_NNMT_PTEN_ID2_C_IAP2_SESN2_TP63AIFM1_ATG12_ATG3_DRAM_FRAP1_CIAP2_TP63 ATG12_CBS_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63AIFM1_ATG7_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_PTEN_TKT_MMP9_CIAP2_TP63AIFM1_DRAM_TKT_CIAP2_SESN2_TP63_VEGF AIFM1_ATG12_ATG3_DRAM_FRAP1_MMP9_CIAP2_TP63ATG12_ATG3_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_CASP8_DRAM_TKT_CIAP2_SESN2_TP63AIFM1_AKT1_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_ATG7_CBS_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_ATG12_ATG7_DRAM_FRAP1_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63AIFM1_ATG3_BCL2L1_DRAM_CIAP2_SESN2_TP63 AIFM1_ATG12_DRAM_PTEN_TKT_CIAP2_SESN2_TP63AIFM1_ATG7_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_BCL2L1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63AIFM1_BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_E2F1_FRAP1_NNMT_TKT_CIAP2_TP63AIFM1_CBS_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63_VEGFAIFM1_DRAM_PTEN_TKT_CIAP2_SESN2_TP63 ATG12_BNIP3_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63AIFM1_DRAM_TKT_BHLHE41_CIAP2_SESN2_TP63 ATG12_CBS_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_TP63 ATG12_DIABLO_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63BCL2L1_DRAM_TKT_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_PRKAA1_TKT_XIAP_CIAP2_TP63BAX_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_RAGE_TP63CBS_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3 ATG3_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3_AGER。
37.如权利要求23所述的方法，所述方法用于预测C组的无病存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表15]
一种两种的组合三种的组合四种的组合
FASLG FAS_FASLG FAS_LC3_FASLG DIABLO_FAS_LC3_FASLG
CIAP2 LC3_FASLG DIABLO_FAS_FASLG FAS_LC3_FASLG_UVRAG
FAS E2F1_FASLG E2F1_LC3_FASLG E2F1_FAS_LC3_FASLG
CSE1L CIAP2_FASLG FAS_FASLG_RPS19BP1 BNIP3_FAS_LC3_FASLG
TCF3 DIABLO_FASLG E2F1_FAS_FASLG DRAM_FAS_LC3_FASLG
FASLG_RPS19BP1 FAS_FASLG_UVRAG ATG7_FAS_LC3_FASLG
FASLG_SESN2 DIABLO_LC3_FASLG FAS_LAMP1_LC3_FASLG
CASP3_FASLG ATG7_FAS_FASLG FAS_FRAP1_LC3_FASLG
FASLG_UVRAG FAS_FASLG_SESN2 ATG3_FAS_LC3_FASLG
FRAP1_FASLG LC3_FASLG_SESN2 FAS_LC3_FASLG_RPS19BP1
PTEN_FASLG FAS_LAMP1_FASLG FAS_LC3_FASLG_SESN3
FASLG_HMGB1 ATG3_FAS_FASLG FAS_LC3_FASLG_SESN2
ATG3_FAS CIAP2_FASLG_SESN3 ATG5_FAS_LC3_FASLG
CASP3_CIAP2 FAS_FRAP1_FASLG FAS_LC3_FASLG_STAT3
TCF3_FASLG FRAP1_LC3_FASLG FAS_LC3_FASLG_SIRT1
ATG7_FASLG BNIP3_LC3_FASLG AKT1_FAS_LC3_FASLG
PTEN_CIAP2 FAS_FASLG_SESN3 FAS_LC3_ID2_FASLG
CDH2_FASLG BNIP3_FAS_FASLG FAS_LC3_FASLG_NAMPT
FASLG_SESN3 DIABLO_FASLG_SESN2 FAS_LC3_BECN1_FASLG
DIABLO_FAS CIAP2_FASLG_UVRAG FAS_LC3_MMP9_FASLG
FAS_LC3 LC3_FASLG_UVRAG DIABLO_FAS_FASLG_UVRAG
ULK1_FASLG LC3_CIAP2_FASLG ATG12_FAS_LC3_FASLG
CSE1L_FASLG DRAM_FAS_FASLG FAS_FASLG_RPS19BP1_UVRAG
CBS_FASLG LC3_FASLG_SESN3 DIABLO_FAS_FASLG_SESN2
FASLG_HMGB2 FAS_FASLG_STAT3 FAS_LC3_FASLG_LAMP2
FAS_UVRAG ATG7_LC3_FASLG FAS_LC3_CDH1_FASLG
LAMP1_FASLG ATG5_FAS_FASLG DIABLO_FAS_FASLG_SESN3
BNIP3_FASLG E2F1_FASLG_SESN2 FAS_LC3_TCF3_FASLG
MMP9_FASLG LC3_ID2_FASLG E2F1_LC3_ID2_FASLG
TKT_FASLG DRAM_LC3_FASLG FAS_LC3_BHLHE41_FASLG
FASLG_STAT3 FAS_TCF3_FASLG DIABLO_FAS_LAMP1_FASLG
AKT1_FASLG AKT1_FAS_FASLG DIABLO_DRAM_FAS_FASLG
FASLG_MMP2 E2F1_ULK1_FASLG FAS_FASLG_SESN2_UVRAG
DRAM_FASLG E2F1_TCF3_FASLG FAS_FASLG_RPS19BP1_SESN3
FASLG_SIRT1 LC3_FASLG_RPS19BP1 DIABLO_FAS_FRAP1_FASLG
ATG12_FASLG LC3_MMP9_FASLG DIABLO_FAS_FASLG_STAT3
CIAP2_RAGE FAS_FASLG_SIRT1 ATG7_DIABLO_FAS_FASLG
FAS_LAMP1 FAS_ULK1_FASLG CSE1L_FAS_LC3_FASLG
ATG5_FASLG FAS_FASLG_NAMPT E2F1_LC3_MMP9_FASLG
ATG3_FASLG LC3_FASLG_SIRT1 DRAM_FAS_FASLG_RPS19BP1
E2F1_FAS CASP3_CIAP2_FASLG DIABLO_FAS_FASLG_RPS19BP1
BECN1_FASLG ATG12_FAS_FASLG FAS_LC3_ULK1_FASLG
E2F1_CIAP2 FAS_BECN1_FASLG DIABLO_FAS_FASLG_SIRT1
CASP8_FASLG ATG5_LC3_FASLG DIABLO_FAS_ID2_FASLG
XIAP_CIAP2 LC3_BECN1_FASLG AKT1_DIABLO_FAS_FASLG
CDR1_FASLG LC3_FASLG_STAT3 DIABLO_FAS_FASLG_NAMPT
FASLG_NAMPT E2F1_FASLG_SESN3 ATG3_FAS_FASLG_SESN2
BNIP3_FAS AKT1_LC3_FASLG FAS_FASLG_RPS19BP1_SESN2
FASLG_LAMP2 FAS_FASLG_LAMP2 DIABLO_FAS_BECN1_FASLG
AGER_FASLG LC3_TCF3_FASLG DIABLO_FAS_CDH1_FASLG
ID2_FASLG LC3_FASLG_NAMPT ATG7_FAS_FASLG_UVRAG
AIFM1_FASLG LC3_CDH1_FASLG DIABLO_FAS_FASLG_LAMP2
FASLG_SESN1 ATG12_LC3_FASLG FAS_FRAP1_FASLG_RPS19BP1
AIFM1_CIAP2 PTEN_CDH1_CIAP2 FAS_LAMP1_FASLG_UVRAG
PRKAA1_CIAP2 LC3_FASLG_LAMP2 E2F1_FAS_LAMP1_FASLG
BCL2L1_CIAP2 DIABLO_FASLG_SESN3 ATG7_FAS_FASLG_RPS19BP1
XIAP_FASLG FAS_CDH1_FASLG E2F1_FAS_FASLG_UVRAG
CDH1_ID2_MMP9_TCF3
五种的组合六种的组合
DIABLO_FAS_LC3_ID2_FASLG BNIP3_DRAM_FAS_LC3_FASLG_SESN2
DRAM_FAS_LC3_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG
DIABLO_DRAM_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2
BNIP3_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_ID2_FASLG_UVRAG
BNIP3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_UVRAG
BNIP3_DRAM_FAS_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN2_UVRAG
BNIP3_DIABLO_FAS_LC3_FASLG DIABLO_FAS_LC3_ID2_FASLG_UVRAG
FAS_LC3_ID2_FASLG_UVRAG DIABLO_FAS_LC3_ID2_FASLG_STAT3
DIABLO_FAS_LC3_FASLG_UVRAG DIABLO_FAS_LC3_ID2_FASLG_SESN3
DIABLO_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_MMP9_FASLG_UVRAG
DIABLO_FAS_LC3_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_FASLG_SESN3
DIABLO_FAS_LC3_FASLG_SIRT1 BNIP3_FAS_LC3_ID2_FASLG_UVRAG
FAS_LC3_MMP9_FASLG_RPS19BP1 DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1
ATG5_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1
BNIP3_FAS_LC3_FASLG_SESN3 BNIP3_FAS_LC3_ID2_FASLG_SESN2
DIABLO_FAS_LC3_BECN1_FASLG BNIP3_DIABLO_FAS_LC3_ID2_FASLG
DIABLO_FAS_LC3_CDH1_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN2
ATG3_FAS_LC3_FASLG_SESN2 DIABLO_FAS_LC3_ID2_FASLG_SIRT1
DRAM_E2F1_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_UVRAG
FAS_LC3_FASLG_SESN2_UVRAG FAS_LC3_MMP9_FASLG_RPS19BP1_UVRAG
DIABLO_FAS_LC3_FASLG_LAMP2 ATG3_FAS_LC3_FASLG_SESN2_SESN3
E2F1_FAS_LC3_ID2_FASLG DRAM_FAS_LC3_FASLG_SESN2_UVRAG
D IABLO_FAS_LC3_FASLG_NAMPT DIABLO_FAS_LC3_ID2_BECN1_FASLG
DIABLO_FAS_LC3_MMP9_FASLG DRAM_FAS_LC3_FASLG_SIRT1_UVRAG
FAS_LC3_FASLG_SIRT1_UVRAG FAS_LC3_ID2_FASLG_SESN2_UVRAG
FAS_LC3_FASLG_SESN3_UVRAG DIABLO_FAS_LC3_CDH1_ID2_FASLG
FAS_LAMP1_LC3_FASLG_UVRAG FAS_LC3_ID2_MMP9_FASLG_RPS19BP1
AKT1_DIABLO_FAS_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN2_SESN3
DIABLO_FAS_FRAP1_LC3_FASLG DIABLO_FAS_LC3_ID2_FASLG_NAMPT
DIABLO_FAS_LC3_BHLHE41_FASLG DIABLO_FAS_LC3_ID2_FASLG_SESN2
FAS_LC3_FASLG_STAT3_UVRAG DIABLO_FAS_LC3_ID2_FASLG_LAMP2
DIABLO_FAS_LC3_FASLG_SESN2 BNIP3_FAS_LC3_FASLG_SESN2_SIRT1
E2F1_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN2_STAT3
BNIP3_FAS_FRAP1_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN3_UVRAG
DIABLO_FAS_LAMP1_LC3_FASLG DIABLO_DRAM_FAS_LC3_FASLG_STAT3
FAS_LC3_BECN1_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG
AKT1_FAS_LC3_FASLG_UVRAG ATG5_FAS_LC3_ID2_FASLG_UVRAG
BNIP3_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN3_UVRAG
FAS_FRAP1_LC3_FASLG_UVRAG DRAM_FAS_LC3_BECN1_FASLG_UVRAG
BNIP3_FAS_LC3_FASLG_STAT3 DIABLO_DRAM_FAS_LC3_CDH1_FASLG
FAS_LC3_CDH1_FASLG_UVRAG AKT1_DIABLO_FAS_LC3_ID2_FASLG
FAS_LC3_FASLG_LAMP2_UVRAG BNIP3_DIABLO_FAS_LC3_MMP9_FASLG
FAS_LC3_MMP9_FASLG_UVRAG DRAM_FAS_LC3_CDH1_FASLG_UVRAG
ATG7_FAS_LC3_FASLG_UVRAG DIABLO_FAS_FRAP1_LC3_ID2_FASLG
ATG7_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_STAT3
BNIP3_FAS_LC3_FASLG_SIRT1 DIABLO_DRAM_FAS_LC3_FASLG_SESN3
DRAM_FAS_LAMP1_LC3_FASLG BNIP3_DIABLO_DRAM_FAS_LC3_FASLG
ATG7_BNIP3_FAS_LC3_FASLG DIABLO_DRAM_FAS_LC3_FASLG_SIRT1
BNIP3_FAS_LAMP1_LC3_FASLG BNIP3_DRAM_FAS_FRAP1_LC3_FASLG
ATG3_FAS_LC3_MMP9_FASLG DIABLO_DRAM_FAS_LC3_BECN1_FASLG
ATG5_DIABLO_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN3
BNIP3_FAS_LC3_ID2_FASLG DIABLO_FAS_LAMP1_LC3_ID2_FASLG
ATG12_DIABLO_FAS_LC3_FASLG DRAM_FAS_LC3_FASLG_LAMP2_UVRAG
E2F1_FAS_LC3_FASLG_SESN3 ATG5_FAS_LC3_FASLG_SESN2_UVRAG
AKT1_BNIP3_FAS_LC3_FASLG FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3
FAS_LC3_FASLG_NAMPT_UVRAG FAS_LAMP1_LC3_ID2_FASLG_UVRAG
ATG12_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG
PTEN_CDH1_ID2_MMP9_TCF3 LC3_CDH1_ID2_MMP9_TCF3_FASLG
七种的组合八种的组合
ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAGBNIP3_FAS_LC3_ID2_FASLG_SESN2_UVRAG ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAGFAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_ID2_FASLG_UVRAG ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAGDRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAGDRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 ATG5_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAGATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1 ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAG ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3 ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAG ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_TCF3_FASLG_UVRAGDIABLO_DRAM_FAS_LC3_ID2_FASLG_STAT3 DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3DIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAGATG5_DRAM_FAS_LC3_ID2_FASLG_UVRAG ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1 ATG3_DIABLO_FAS_LC3_ID2_MMP9_FASLG_SESN2ATG5_FAS_LC3_ID2_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAGATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAGDIABLO_DRAM_FAS_LC3_ID2_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2DIABLO_DRAM_FAS_LC3_CDH1_ID2_FASLG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1DRAM_FAS_LC3_ID2_FASLG_SIRT1_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3DIABLO_DRAM_FAS_LC3_ID2_FASLG_SIRT1 ATG3_FAS_LC3_ID2_MMP9_TCF3_FASLG_SESN2BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3 ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3BNIP3_FAS_LC3_ID2_MMP9_FASLG_UVRAG BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN2_UVRAGDIABLO_DRAM_FAS_LC3_ID2_BECN1_FASLG ATG5_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAGDRAM_FAS_LC3_ID2_FASLG_SESN3_UVRAG BNIP3_FAS_LC3_CDH1_ID2_FASLG_SESN2_UVRAGATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2 BNIP3_FAS_LC3_ID2_FASLG_SESN2_SIRT1_UVRAGBNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3 ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3BNIP3_FAS_LC3_ID2_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_CDH1_ID2_FASLG_SESN2DIABLO_DRAM_FAS_LC3_ID2_FASLG_LAMP2 BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN3_UVRAGBNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2 AKT1_BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2ATG5_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_LAMP2_SESN2DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_UVRAG ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3DRAM_FAS_LAMP1_LC3_ID2_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2_UVRAGDIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN2 BNIP3_FAS_LC3_ID2_FASLG_LAMP2_SESN2_UVRAGATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2 BNIP3_FAS_LC3_ID2_BECN1_FASLG_SESN2_UVRAGAKT1_BNIP3_DRAM_FAS_LC3_FASLG_SESN2 BNIP3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAGDRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 BNIP3_DRAM_FAS_LC3_ID2_TCF3_FASLG_UVRAGATG3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAGDRAM_FAS_LC3_ID2_FASLG_STAT3_UVRAG ATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_CDH1_FASLG_UVRAG BNIP3_DRAM_FAS_LAMP1_LC3_ID2_FASLG_SESN2ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 ATG3_FAS_FRAP1_LC3_ID2_MMP9_FASLG_SESN2DRAM_FAS_LC3_ID2_BECN1_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2E2F1_LC3_CDH1_ID2_MMP9_TCF3_FASLG FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG_UVRAG。
38.如权利要求23～37中任一项所述的方法，其中，蛋白的表达水平或表达模式用选自以下方法中的一种或多种来检测：RT-PCR、竞争性RT-PCR、实时RT-PCR、RNA酶保护测定、RNA印迹、DNA微阵列、蛋白质印迹、ELISA(酶联免疫吸附测定)、放射免疫测定、放射免疫扩散、Ouchterlony免疫扩散、火箭免疫电泳、组织免疫染色、免疫沉淀测定、补体结合测定、FACS或蛋白芯片。
39.一种预测肝癌预后的方法，所述方法包括：
(A)检测获自肝癌患者的样品中的选自由下表所示的基因组成的组的一种或至少两种基因的表达水平或表达模式中的一项或多项；和
(B)将步骤(A)的结果与对照组的测量结果进行比较，从而预测肝癌预后：
[表2]
40.如权利要求39所述的方法，其中，由基因组成的所述组还包含下表所示的基因：
[表3]
41.如权利要求39或40所述的方法，其中，蛋白的表达水平或表达模式用选自以下方法中的一种或多种来检测：RT-PCR、竞争性RT-PCR、实时RT-PCR、RNA酶保护测定、RNA印迹、DNA微阵列、蛋白质印迹、ELISA(酶联免疫吸附测定)、放射免疫测定、放射免疫扩散、Ouchterlony免疫扩散、火箭免疫电泳、组织免疫染色、免疫沉淀测定、补体结合测定、FACS或蛋白芯片。

说明书全文

预测肝癌预后的组合物或 试剂盒以及预测肝癌预后的方法

技术领域

[0001] 本发明涉及一种用于预测肝癌预后的生物标志物。更具体而言，本发明涉及一种预测肝癌预后的组合物或试剂盒及预测肝癌预后的方法。

背景技术

[0002] 肝癌已知是世界上最致命的癌症之一。特别而言，据报道，在亚洲和撒哈拉以南的非洲每年有至少约50万人死于肝癌。肝癌大体上可以分为源于肝细胞本身的肝细胞癌和
从其他组织传播到肝脏的转移性肝癌。至少约90％的肝癌是肝细胞癌，通常将术语“肝癌”
理解为肝细胞癌。

[0003] 肝癌预后是指对肝癌患者的多种状况的预估，例如从肝癌完全恢复的可能性、治疗后复发的可能性、诊断患有肝癌后患者存活的可能性等。其视不同条件(例如疾病的严
重程度、诊断点、治疗进程等)而有所不同。肝癌仅在根据其预后来正确地使用各种治疗方
法时能够得到高效地治疗。例如，对于被评估为预后良好的患者，有必要避免使用可能为患
者带来严重副作用的危险治疗方法(例如攻击性的化学治疗或手术、放射治疗)而选择相
对温和、保守和安全的治疗方法。另一方面，对于被评估为预后不佳的患者，为了延长生存
期或提高生存率，应当积极地进行化学治疗或手术、诸如放射治疗等治疗方法。

[0004] 根据迄今为止已进行的研究可知，对于已发生进展的肝癌，其预后非常差，并且显示出自诊断起6个月内死亡、平均存活期仅为4个月的高致死率。但是，尺寸小于3cm的
肝癌却具有良好的预后，已知其在不进行任何特殊治疗时及在术后的1年内的生存率为
90％，5年内的生存率为约40％～50％。然而，用现有技术来精确地预估肝癌预后是非常困
难的。为了准确地预估预后，必须有一种将患者分类为各个风险组的分析方法。然而，迄今
为止，预后仅仅是根据诊断时的临床病理学肝癌分期以及初步的外科手术治疗来确定，并
不存在准确地预估肝癌预后的手段。

[0005] 常规的分析方法包括BCLC(巴塞罗那临床肝癌)分期系统。该系统是通过在对患者进行外科手术前确定患者的肝癌分期来将肝癌患者分类从而确定治疗方法(肝
脏切除、肝脏移植或射频消蚀等，视疾病分期而定)的系统(Llovert JM，Bru C，Bruix
J.Prognosis of hepatocellular carcinoma：the BCLC staging classification.Semin
Liver Dis.1999；19(3)：329-338)。

[0006] 然而，可惜的是，仅凭肝癌分期不能精确地确定每个肝癌患者的预后。因此，有必要开发一种使用基因标志物来对肝癌患者的预后进行精确预测的技术。即，基于每位个体
患者的分期和预后结果来选择被预期为对特定治疗方法(例如，肝脏切除术)响应良好的
患者，并向这些患者提供所述治疗，从而能够改进肝癌患者的整体治疗结果，并能够预期产
生如节省医疗成本等社会经济效应。

[0007] 同时，对于UVRAG、NAMPT、STAT3、CIAP2、BHLHE41、MMP2、SESN2、HMGB1、SIRT1、RPS19BP1、LAMP2、AGER、SESN3、ID2、TCF3、HMGB2、TP63、RAGE、KIAA1967、SATB1、RAPTOR、
SESN1、CCNG2、CDH1、FASLG、CASP3、BECN1、CDH2、TWIST1、MMP9、VEGF、ATG12、DIABLO、E2F1、
LAMP1、LC3、ATG7、TKT、AIFM1、BNIP3、ATG3、DRAM、ATG5、NNMT、PRKAA1、CASP8、ULK1、BCL2L1、
FAS、CSE1L、FRAP1、AKT1、BAX、BCL2、PTEN、CBS、XIAP等蛋白，它们在肝癌组织中的表达水
平或表达模式如何随肝癌的分期而变化，以及如何能够将它们用于根据分期来预测肝癌预
后，都是已知的。虽然在一些情况下已使用上述蛋白或一些编码上述蛋白的基因来作为肝
癌预后的标志物，但是尚无使用它们来作为根据分期来进行肝癌预后的标志物的情况。

[0008] 在进行了有关预测肝癌预后的研究后，本发明人发现了表达水平和表达模式(根据肝癌的分期)发生显著变化的基因，并完成了本发明。

具体实施方式

[0009] 技术主题

[0010] 本发明所要解决的一个技术主题是提供一种用于预测肝癌预后的生物标志物，所述生物标志物能够(根据癌症的分期)对预后进行预测。

[0011] 本发明所要解决的另一技术主题是提供一种用于预测肝癌预后的组合物或试剂盒，所述组合物或试剂盒能够(根据癌症的分期)对预后进行预测。

[0012] 本发明所要解决的又一个技术主题是提供一种用于预测肝癌预后的方法，所述方法可以用来(根据癌症的分期)对预后进行预测。

[0013] 实现主题的方法

[0014] 本发明提供一种用于预测肝癌预后的生物标志物，优选是用于根据分期来预测肝癌预后的生物标志物，所述生物标志物是选自下表1所列的基因和这些基因所编码的蛋白
中的至少一种。

[0015] [表1]

[0016]

[0017]

[0018] 在上表中，NCBI GI(Geninfo标识符)是指由美国国家生物技术信息中心(NCBI)提供的序列识别号，其由登录号和版本号组成。

[0019] 在本发明中，“肝癌”包括源于肝细胞本身的肝细胞癌和从其他组织传播到肝脏的转移性肝癌。优选的是，“肝癌”指肝细胞癌。

[0020] 在本发明中，“用于预测肝癌预后的标志物”是指基因标志物，其作为在肝癌出现后预测肝癌预后的标准。该标志物具有显著低的p值，其中所述p值根据所述标志物在具
有不同预后的患者的肝癌细胞和/或组织中的表达差异计算得到。优选的是，所述标志物
的p值小于0.05。

[0021] 此外，本发明提供用于预测肝癌预后的组合物或试剂盒，所述组合物或试剂盒包含：对选自表1所示的组的一种或至少两种基因中的每一种分别具有特异性的核酸，或对
所述基因编码的蛋白有特异性的抗体；且所述组合物或试剂盒用于根据选自下述各组的一
个或多个组中的分期来预测肝癌预后：A1组{门静脉侵袭阴性患者组，患者处于BCLC(巴
塞罗那临床肝癌)分期系统的0期或A期，具有1个尺寸为5cm以下的肿瘤或3个以下的
尺寸为3cm以下的肿瘤}，A2组{门静脉侵袭阴性患者组，患者具有尺寸大于5cm的肿瘤}，
B组{门静脉侵袭阴性患者组，患者处于BCLC分期系统的中期，具有多个尺寸大于3cm的
肿瘤或数量大于3的多个肿瘤}，或C组{门静脉侵袭阳性患者组，不论肿瘤尺寸和数量如
何}。

[0022] 所述至少两种基因可以是至少三种、四种、五种、六种、七种或八种以上基因。

[0023] 优选的是，由基因组成的所述组可以是下表2所示的基因组成的组。

[0024] [表2]

[0025]

[0026] 更优选的是，由基因组成的所述组还可以包含下表3所示的基因。

[0027] [表3]

[0028]

[0029]

[0030] 在上表2所示的基因中，CDH1、ID2、MMP9、TCF3可以从表2中排除，并且可以进一步包含在表3所示的基因的组中。

[0031] BCLC分类(即，图1中所用的分类)是通过在对肝癌患者进行外科手术前确定肝癌的分期来将肝癌患者分类从而确定治疗方法(肝脏切除、肝脏移植或射频消蚀等，视分
期而定)的系统(Llovert JM，Bru C，Bruix J.Prognosis of hepatocellular carcinoma：
the BCLC staging classification.Semin Liver Dis.1999；19(3)：329-338)。在图1中，
体力状态测试(PST)分为阶段0～阶段4。阶段0是指体力无问题的情况；阶段1是指患
者能够进行轻度工作的情况；阶段2是指患者不能工作但可以照料自己的情况；阶段3是
指患者能够有限地照料自己且日常生活的至少50％是在床上或椅上度过的阶段；阶段4是
指患者不能进行任何活动、不能照料自己且全天都在床上或椅上度过的情况。在Okuda分
期中，各期基于四种标准来确定，并根据癌的尺寸大于还是小于整个肝脏的50％、根据是否
存在腹水并根据胆红素数值(小于或大于3mg/dL)和白蛋白数值(小于或大于3g/dL)来
将这些期分类为I期、II期、III期。Child-Pugh分级是评估肝硬化患者的肝功的指数。
评估了白蛋白值(＞3.5g/dL：1分；2.8～3.5g/dL：2分；＜2.8g/dL：3分)、胆红素值
(＜2.0mg/dL：1分；2.0～3.0mg/dL：2分；＞3.0mg/dL：3分)、凝血酶原时间值(＞50％：
1分；40％～50％：2分；＜40％：3分)、腹水的存在(无：1分；略有：2分；中等：3分)、
脑病分级(无：1分；不确定的脾气变化、抑郁、震颤、嗜睡、讲话缓慢且口齿不清、扑翼样震
颤、行走困难：2分；肌肉僵直、失定向、意识错乱、间歇性肌痛性痉挛、眼球震颤、昏迷、瞳孔
散大、去大脑动物姿势：3分)等。6分以下为A类，7～9分为B类，10分以上为C类。

[0032] 以上预后能够预示复发、存活或无病存活，并且可以作为进行了癌症肝脏切除术后的预后。“复发”指的是进行了癌症肝脏切除术后的存活者的肝癌复发。“存活”是指在
癌症肝脏切除术后5年内的存活率。无病存活是指进行癌症肝脏切除术后无复发的存活。

[0033] 优选的是，所述组合物或试剂盒用于预测A1组的复发预后，并且所述基因是选自下表4所示的基因或基因的组中的一种或多种。

[0034] [表4]

[0035]一种两种的组合三种的组合四种的组合
BCL2L1 FRAP1_SESN1 FRAP1_CASP3_CDH2 ID2_NAMPT_RPS19BP1_SESN3
BECN1 FRAP1_TWIST1 ID2_CDH2_SESN3 FRAP1_LC3_CASP3_CDH2
BAX FRAP1_CASP3 FRAP1_CDH2_SESN1 FRAP1_TKT_CASP3_CDH2
CDH2 FRAP1_CCNG2 FRAP1_LC3_CASP3 BAX_FRAP1_LC3CDH2
NAMPT BAX_FRAP1 FRAP1_LC3_TWIST1 ID2_CDH2_NAMPT_SESN3
TWIST1 FRAP1_NNMT BAX_FRAP1_LC3 CBS_ID2_CDH2_SESN3
RPS19BP1 BCL2L1_FRAP1 FRAP1_CDH2_TWIST1 FRAP1_LC3_CDH2_KIAA1967
MMP2 AIFM1_FRAP1 FRAP1_NNMT_CDH2 FRAP1_CDH2_SESN1_STAT3
SESN3 FRAP1_RAGE FRAP1_LC3_NNMT FRAP1_LC3_NNMT_CDH2
ID2 FRAP1_VEGF BAX_FRAP1_CDH2 FRAP1_LC3_CDH2_RAPTOR
AGER ID2_CDH2 FRAP1_SESN1_STAT3 ID2_CDH2_RPS19BP1_SESN3
ATG12 FRAP1_PTEN AIFM1_FRAP1_CDH2 FRAP1_LC3_CDH2_TWIST1
NAMPT_SESN3 FRAP1_LC3_VEGF FRAP1_LC3_CDH2_VEGF
BCL2_FRAP1 FRAP1_NNMT_MMP2 FRAP1_LC3_SESN1_STAT3
CDH2_SESN3 FRAP1_LC3_RAGE FRAP1_LC3_CDH2_RAGE
FRAP1_RAPTOR FRAP1_CCNG2_CDH2 FRAP1_LC3_NNMT_STAT3
FRAP1_KIAA1967 BCL2L1_FRAP1_CDH2 ID2_CDH2_MMP2_SESN3
FRAP1_XIAP FRAP1_CDH2_VEGF FRAP1_LC3_CASP3_STAT3
BECN1_SESN3 FRAP1_LC3_CCNG2 AIFM1_FRAP1_LC3_CDH2
HMGB1_TWIST1 FRAP1_CASP3_MMP2 BCL2L1_FRAP1_LC3_CDH2
ID2_NAMPT BCL2L1_FRAP1_LC3 FRAP1_LC3_PTEN_CDH2
FRAP1_PRKAA1 FRAP1_LC3_SESN1 BAX_FRAP1_LC3_BECN1
ID2_RPS19BP1 FRAP1_CDH2_KIAA1967 BAX_FRAP1_LC3_RPS19BP1
BAX_LC3 AIFM1_FRAP1_LC3 FRAP1_CASP3_CDH2_STAT3
FRAP1_TP63 FRAP1_LC3_RAPTOR LC3_HMGB1_STAT3_TWIST1
ATG12_SESN3 FRAP1_CDH2_RAGE BAX_FRAP1_TKT_CDH2
BAX_TWIST1 BAX_FRAP1_MMP2 FRAP1_LC3_CCNG2_CDH2
RPS19BP1_SESN3 FRAP1_LC3_PTEN FRAP1_TKT_CDH2_SESN1
BAX_MMP2 FRAP1_TKT_CASP3 FRAP1_LC3_HMGB1_TWIST1
SESN1_STAT3 FRAP1_PTEN_CDH2 FRAP1_NNMT_TKT_CDH2
LC3_TWIST1 FRAP1_TKT_TWIST1 BAX_FRAP1_LC3_MMP2

[0036]MMP2_NAMPT FRAP1_LC3_KIAA1967 FRAP1_LC3_CCNG2_STAT3
ID2_BECN1 BAX_FRAP1_TKT FRAP1_LC3_STAT3_TWIST1
BCL2L1_LC3 BCL2_FRAP1_CDH2 FRAP1_TKT_CDH2_TWIST1
MMP2_RPS19BP1 FRAP1_HMGB1_TWIST1 FRAP1_LC3_NNMT_MMP2
ATG7_BCL2L1 FRAP1_RPS19BP1_TWIST1 BAX_FRAP1_TKT_MMP2
ID2_TWIST1 FRAP1_CDH2_RAPTOR FRAP1_NNMT_CDH2_MMP2
CDH2_HMGB1 FRAP1_TKT_SESN1 FRAP1_LC3_CDH2_SESN1
CDH2_MMP2 FRAP1_RPS19BP1_SESN1 BAX_FRAP1_LC3_TKT
ATG7_TWIST1 BAX_FRAP1_BECN1 FAS_FRAP1_CDH2_SESN1
BAX_SESN3 ID2_NAMPT_SESN3 BAX_FAS_FRAP1_LC3
FASLG_NAMPT FRAP1_CCNG2_STAT3 FRAP1_CASP3_CDH2_MMP2
ATG7_BAX BCL2L1_FRAP1_MMP2 ID2_FASLG_NAMPT_SESN3
TKT_NAMPT BCL2_FRAP1_LC3 FRAP1_ID2_CDH2_TWIST1
STAT3_TWIST1 FASLG_NAMPT_SESN3 FRAP1_CDH2_HMGB1_TWIST1
BCL2L1_MMP2 AIFM1_FRAP1_MMP2 BAX_FRAP1_BECN1_CDH2
LC3_KIAA1967 FRAP1_CCNG2_RPS19BP1 DRAM_ID2_CDH2_SESN3
BAX_BECN1 BAX_FRAP1_RPS19BP1 FRAP1_LC3_RPS19BP1_TWIST1
ATG12_ID2 FAS_FRAP1_SESN1 AIFM1_FRAP1_TKT_CDH2
BECN1_MMP2 BCL2L1_FRAP1_TKT FRAP1_TKT_CCNG2_CDH2
AKT1_BAX FRAP1_NNMT_STAT3 BCL2L1_FRAP1_TKT_CDH2
LC3_RAPTOR FRAP1_MMP2_SESN1 DIABLO_ID2_CDH2_SESN3
BAX_RPS19BP1 FRAP1_ID2_TWIST1 BCL2_FRAP1_LC3_CDH2
BAX_TKT FRAP1_CASP3_STAT3 FRAP1_LC3_CASP3_FASLG
BAX_SATB1 FRAP1_TKT_CCNG2 FRAP1_CDH2_RPS19BP1_SESN1
LC3_NAMPT FRAP1_MMP2_VEGF FRAP1_LC3_CASP3_MMP2
KIAA1967_MMP2 FRAP1_MMP2_RAPTOR ID2_CDH2_HMGB2_SESN3
CDH1_ID2_MMP9_TCF3

[0037]五种的组合六种的组合
FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_LC3_BECN1_CASP3_CDH2_STAT3
ID2_MMP2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_NNMT_BECN1_CDH2_STAT3
FRAP1_LC3_CDH2_SESN1_STAT3 FRAP1_LC3_TKT_CASP3_CDH2_STAT3
ID2_CDH2_MMP2_RPS19BP1_SESN3 ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3
FRAP1_LC3_NNMT_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_SESN1_STAT3
BAX_FRAP1_LC3_BECN1_CDH2 ID2_CDH2_FASLG_NAMPT_RPS19BP1_SESN3
ID2_FASLG_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_CASP3_CDH2_HMGB1_STAT3
BAX_FRAP1_LC3_TKT_CDH2 FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3
FRAP1_LC3_BECN1_CDH2_RAPTOR FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3
FRAP1_LC3_CDH2_STAT3_TWIST1 FRAP1_LC3_CDH2_HMGB1_STAT3_TWIST1
FRAP1_LC3_CCNG2_CDH2_STAT3 ID2_HMGB2_MMP2_NAMPT_RPS19BP1_SESN3
ID2_CDH2_FASLG_NAMPT_SESN3 AIFM1_FRAP1_LC3_BECN1_CDH2_STAT3
LC3_CDH2_HMGB1_STAT3_TWIST1 ID2_MMP2_NAMPT_RPS19BP1_SESN3_STAT3
ID2_CDH2_HMGB1_RPS19BP1_SESN3 ID2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3
ID2_CDH2_MMP2_NAMPT_SESN3 AKT1_FAS_BECN1_CDH2_STAT3_TP63
FRAP1_LC3_BECN1_CDH2_KIAA1967 FRAP1_LC3_CCNG2_CDH2_RPS19BP1_STAT3
BAX_FRAP1_LC3_CDH2_RPS19BP1 AKT1_ATG12_BECN1_CDH2_STAT3_TP63
ID2_HMGB2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3
ID2_NAMPT_RPS19BP1_SESN3_STAT3 CSE1L_FRAP1_LC3_CASP3_CDH2_STAT3
FRAP1_LC3_CDH2_HMGB1_TWIST1 FRAP1_LC3_BECN1_CDH2_RAGE_STAT3
FRAP1_TKT_CDH2_SESN1_STAT3 FAS_FRAP1_LC3_NNMT_CDH2_STAT3
CSE1L_ID2_CDH2_RPS19BP1_SESN3 ID2_HMGB1_MMP2_NAMPT_RPS19BP1_SESN3
FRAP1_LC3_TKT_CASP3_CDH2 FRAP1_LC3_TKT_CDH2_SESN1_STAT3
BAX_FAS_FRAP1_LC3_CDH2 FRAP1_LC3_NNMT_CDH2_MMP2_STAT3
FAS_FRAP1_LC3_CDH2_RAPTOR FRAP1_LC3_NNMT_TKT_CDH2_STAT3
LC3_CASP3_CDH2_HMGB1_STAT3 BAX_FRAP1_LC3_BECN1_CDH2_STAT3
FAS_FRAP1_LC3_CDH2_KIAA1967 FRAP1_LC3_CASP3_CDH2_SIRT1_STAT3
AIFM1_FRAP1_LC3_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR_RPS19BP1
FRAP1_LC3_BECN1_CASP3_STAT3 CBS_FRAP1_LC3_CASP3_CDH2_STAT3
FRAP1_BECN1_CASP3_CDH2_STAT3 FAS_FRAP1_LC3_CASP3_CDH2_STAT3
ID2_CDH2_NAMPT_SESN3_STAT3 AKT1_ATG12_FAS_CDH2_STAT3_TP63

[0038]LC3_ID2_NAMPT_RPS19BP1_SESN3 LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1
FRAP1_LC3_NNMT_MMP2_STAT3 FRAP1_LC3_BECN1_CDH2_STAT3_TWIST1
BAX_FRAP1_LC3_CASP3_CDH2 FRAP1_LC3_CASP3_CDH2_MMP2_STAT3
FRAP1_TKT_CASP3_CDH2_STAT3 ID2_MMP9_MMP2_NAMPT_RPS19BP1_SESN3
LC3_HMGB1_RPS19BP1_STAT3_TWIST1 CSE1L_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_CDH2_RPS19BP1_SESN1_STAT3 FRAP1_LC3_BECN1_CDH2_STAT3_VEGF
CBS_FRAP1_LC3_CASP3_CDH2 BAX_FRAP1_LC3_TKT_BECN1_CDH2
FRAP1_LAMP1_TKT_CASP3_CDH2 FRAP1_LC3_NNMT_CASP3_CDH2_STAT3
ID2_CDH2_HMGB1_NAMPT_SESN3 FRAP1_TKT_BECN1_CASP3_CDH2_STAT3
ID2_HMGB1_NAMPT_RPS19BP1_SESN3 ID2_FASLG_NAMPT_RPS19BP1_SESN3_STAT3
AKT1_ID2_NAMPT_RPS19BP1_SESN3 FAS_FRAP1_LC3_CDH2_KIAA1967_RPS19BP1
FRAP1_LC3_TKT_CDH2_KIAA1967 FRAP1_LC3_BECN1_CDH2_SESN1_STAT3
FRAP1_LC3_CASP3_CDH2_HMGB1 ID2_CDH2_FASLG_NAMPT_SESN3_STAT3
ATG7_FRAP1_LC3_CASP3_CDH2 FRAP1_LC3_TKT_CDH2_STAT3_TWIST1
BAX_FRAP1_LC3_TKT_MMP2 ATG5_FRAP1_LC3_CASP3_CDH2_STAT3
FRAP1_LC3_CDH2_RAPTOR_RPS19BP1 ID2_CDH2_MMP2_RPS19BP1_SESN3_STAT3
FRAP1_LC3_RPS19BP1_SESN1_STAT3 FAS_LC3_CDH2_HMGB1_STAT3_TWIST1
BAX_FRAP1_LC3_CDH2_MMP2 AIFM1_FRAP1_LC3_TKT_CDH2_STAT3
ID2_TCF3_CDH2_RPS19BP1_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_FASLG
FRAP1_TKT_CASP3_CDH2_FASLG DRAM_ID2_MMP2_NAMPT_RPS19BP1_SESN3
FAS_FRAP1_CDH2_SESN1_STAT3 FRAP1_LC3_CASP3_CDH2_NAMPT_STAT3
CBS_ID2_NAMPT_RPS19BP1_SESN3 FAS_FRAP1_LC3_CCNG2_CDH2_STAT3
FRAP1_LC3_CDH2_KIAA1967_MMP2 BAX_FAS_FRAP1_LC3_CDH2_RPS19BP1
FAS_FRAP1_LC3_CASP3_CDH2 BNIP3_FRAP1_LC3_CASP3_CDH2_STAT3
BAX_CBS_FRAP1_LC3_CDH2 FRAP1_LC3_CDH2_RPS19BP1_STAT3_TWIST1
FRAP1_LC3_TKT_CDH2_RAPTOR FRAP1_LC3_MMP9_CASP3_CDH2_STAT3
CDH1_ID2_MMP9_TCF3_RPS19BP1 CDH1_ID2_MMP9_TCF3_RPS19BP1_SESN3

[0039]七种的组合八种的组合
AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63
FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63
FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63
FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63
AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63
ID2_CDH2_FASLG_NAMPT_RPS19BP1_SESN3_STAT3 AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63
FRAP1_LC3_NNMT_TKT_BECN1_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63
AKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63
FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 FAS_FRAP1_LC3_BECN1_CASP3_CDH2_RPS19BP1_STAT3
FAS_FRAP1_LC3_CCNG2_CDH2_RPS19BP1_STAT3 AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63
FRAP1_LC3_BECN1_CASP3_CDH2_HMGB1_STAT3 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_FASLG_STAT3
ID2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3_STAT3 CSE1L_FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3
FRAP1_LC3_NNMT_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63
CBS_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 FAS_FRAP1_LC3_NNMT_BECN1_CDH2_RPS19BP1_STAT3
FRAP1_LC3_BECN1_CASP3_CDH2_SIRT1_STAT3 AKT1_CASP8_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63
CSE1L_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 FRAP1_LC3_NNMT_TKT_BECN1_CDH2_FASLG_STAT3
FRAP1_LC3_TKT_CASP3_CDH2_HMGB1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63
FRAP1_LC3_TKT_CDH2_HMGB1_STAT3_TWIST1 AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63
ATG5_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63
CSE1L_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 ID2_CDH2_FASLG_HMGB1_HMGB2_NAMPT_RPS19BP1_SESN3
FRAP1_LC3_BECN1_CASP3_CDH2_HMGB2_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_CIAP2_STAT3_TP63
AKT1_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63
FAS_FRAP1_LC3_CDH2_MMP2_RAPTOR_RPS19BP1 ID2_CDH2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3_STAT3
AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63
FRAP1_LC3_BECN1_CASP3_CDH2_FASLG_STAT3 AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63
ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3 AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63
AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RPS19BP1_SESN2_STAT3_TP63
FAS_FRAP1_LC3_TKT_CDH2_SESN1_STAT3 AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63
CBS_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 AKT1_LC3_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63
AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63
FRAP1_LC3_BECN1_CDH2_HMGB1_STAT3_TWIST1 FAS_FRAP1_LC3_CASP3_CDH2_FASLG_RPS19BP1_STAT3

[0040]CSE1L_FRAP1_LC3_TKT_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_CASP3_CDH2_STAT3_TP63
FRAP1_LC3_NNMT_BECN1_CDH2_SIRT1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_HMGB2_STAT3_TP63
AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63
ID2_CDH2_FASLG_HMGB1_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_FASLG_HMGB1_STAT3
ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3_STAT3 FAS_FRAP1_LC3_NNMT_CDH2_MMP2_RPS19BP1_STAT3
FRAP1_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 FAS_FRAP1_LC3_BECN1_CDH2_RPS19BP1_SESN1_STAT3
FAS_FRAP1_LC3_CDH2_KIAA1967_MMP2_RPS19BP1 FAS_FRAP1_LC3_TKT_CDH2_RPS19BP1_SESN1_STAT3
FRAP1_LC3_BECN1_CASP3_CDH2_RPS19BP1_STAT3 AKT1_ATG12_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63
FRAP1_LC3_TKT_CASP3_CDH2_FASLG_STAT3 AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63
BNIP3_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63
FRAP1_LC3_CASP3_CDH2_HMGB1_MMP2_STAT3 FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_SIRT1_STAT3
FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 FAS_FRAP1_LC3_CDH2_FASLG_RPS19BP1_SESN1_STAT3
ID2_HMGB1_HMGB2_MMP2_NAMPT_RPS19BP1_SESN3 AKT1_FAS_NNMT_BECN1_CDH2_RPS19BP1_STAT3_TP63
FRAP1_LC3_TKT_BECN1_CDH2_FASLG_RAPTOR CSE1L_FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3
FRAP1_LC3_NNMT_BECN1_CDH2_FASLG_STAT3 FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTOR_RPS19BP1
FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1 AKT1_FAS_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63
FRAP1_LC3_MMP9_BECN1_CASP3_CDH2_STAT3 FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63_TWIST1
FAS_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 FAS_FRAP1_LC3_TKT_CASP3_CDH2_RPS19BP1_STAT3
AIFM1_FAS_FRAP1_LC3_CDH2_RPS19BP1_STAT3 ID2_CDH2_FASLG_HMGB1_NAMPT_RPS19BP1_SESN3_STAT3
AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63 FAS_FRAP1_LC3_BECN1_CDH2_FASLG_RAPTOR_RPS19BP1
AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 CSE1L_FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3
ID2_CDH2_HMGB1_MMP2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_HMGB1_STAT3
AKT1_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_BECN1_CCNG2_CDH2_RPS19BP1_STAT3
AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 FAS_FRAP1_LC3_TKT_BECN1_CDH2_FASLG_RAPTOR
ATG5_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 AKT1_ATG12_FAS_TKT_BECN1_CDH2_STAT3_TP63
FRAP1_LC3_CASP3_CDH2_HMGB1_RPS19BP1_STAT3 FRAP1_LC3_BECN1_CASP3_CDH2_FASLG_HMGB1_STAT3
CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3 CDH1_ID2_MMP9_TCF3_CDH2_MMP2_RPS19BP1_SESN3

[0041] 优选的是，所述组合物或试剂盒用于预测A1组的存活预后，并且所述基因是选自下表5所示的基因或基因的组中的一种或多种。

[0042] [表5]

[0043]一种两种的组合三种的组合四种的组合
ID2 CDH1_ID2 ATG12_CDH1_ID2 ATG12_CDH1_ID2_HMGB2
CDH1 ATG12_CDH1 CDH1_ID2_HMGB2 CDH1_ID2_AGER_HMGB2
LC3 LAMP1_ID2 ATG12_CDH1_HMGB2 ATG12_CDH1_ID2_AGER
TKT BNIP3_ID2 CDH1_ID2_AGER ATG12_CDH1_TCF3_HMGB2
AKT1 ATG12_ID2 DRAM_CDH1_ID2 ATG12_DRAM_CDH1_ID2
AIFM1 CDH1_HMGB2 E2F1_CDH1_ID2 AIFM1_CASP8_LC3_CDH1
BNIP3 ID2_HMGB2 CDH1_ID2_LAMP2 ATG12_CDH1_AGER_HMGB2
LAMP1 E2F1_ID2 TKT_CDH1_ID2 ATG12_CDH1_ID2_BECN1
FRAP1 TKT_ID2 LAMP1_CDH1_ID2 ATG12_DRAM_CDH1_HMGB2
DRAM_ID2 CDH1_ID2_MMP2 DRAM_CDH1_ID2_HMGB2
ATG5_ID2 ATG12_DRAM_CDH1 ATG12_CDH1_BHLHE41_HMGB2
ID2_BECN1 CSE1L_CDH1_ID2 CDH1_ID2_HMGB2_LAMP2
ID2_AGER CDH1_ID2_MMP9 ATG12_CDH1_BECN1_HMGB2
ID2_MMP2 BNIP3_CDH1_ID2 E2F1_CDH1_ID2_HMGB2
ATG3_ID2 CDH1_ID2_BECN1 ATG12_DIABLO_CDH1_BHLHE41
ID2_LAMP2 ATG12_CDH1_BHLHE41 CDH1_ID2_BECN1_HMGB2
ULK1_CDH1 ULK1_CDH1_ID2 ATG12_ATG5_CDH1_HMGB2
CSE1L_ID2 LC3_CDH1_ID2 DRAM_CDH1_ID2_AGER
TKT_CDH1 ATG12_CDH1_TCF3 LAMP1_CDH1_ID2_HMGB2
LC3_CDH1 ATG5_CDH1_ID2 ATG12_BNIP3_CDH1_ID2
ID2_MMP9 ATG3_CDH1_ID2 ATG12_CSE1L_CDH1_ID2
LC3_ID2 DIABLO_CDH1_ID2 ATG12_CDH1_ID2_MMP2
FRAP1_ID2 CASP8_CDH1_ID2 ATG12_CASP8_CDH1_ID2
CASP8_ID2 ATG12_ULK1_CDH1 ATG12_ATG3_CDH1_HMGB2
ID2_CIAP2 ATG12_CDH1_BECN1 ATG12_CDH1_ID2_MMP9

[0044]ID2_UVRAG ATG12_BNIP3_ID2 CDH1_ID2_HMGB2_MMP2
DIABLO_ID2 CDH1_ID2_CIAP2 ATG12_ATG3_CDH1_ID2
DRAM_CDH1 CBS_CDH1_ID2 ATG12_CASP8_CDH1_HMGB2
ID2_SIRT1 CDH1_ID2_HMGB1 ATG12_LAMP1_CDH1_ID2
FAS_ID2 CDH1_ID2_SIRT1 CDH1_ID2_AGER_BECN1
CDH1_AGER LAMP1_ID2_HMGB2 ATG12_FAS_CDH1_HMGB2
ID2_STAT3 CDH1_ID2_UVRAG ATG12_TKT_CDH1_ID2
CBS_ID2 AIFM1_LC3_CDH1 CDH1_ID2_MMP9_HMGB2
CDH1_MMP2 ATG12_CDH1_AGER ATG12_CDH1_HMGB1_HMGB2
AKT1_ID2 CDH1_ID2_STAT3 ATG12_CDH1_MMP9_HMGB2
ID2_CDH2 ATG12_LAMP1_ID2 ATG12_ATG5_CDH1_ID2
ATG7_ID2 ATG12_LC3_CDH1 ATG5_CDH1_ID2_HMGB2
ID2_HMGB1 CDH1_AGER_HMGB2 ATG3_CDH1_ID2_HMGB2
ULK1_ID2 FAS_CDH1_ID2 ATG12_DIABLO_CDH1_ID2
CDH1_LAMP2 ATG7_CDH1_ID2 CSE1L_CDH1_ID2_HMGB2
ATG5_CDH1 ATG12_CDH1_MMP2 ATG12_CDH1_CIAP2_HMGB2
ID2_SATB1 ATG12_CASP8_CDH1 ATG12_CDH1_ID2_UVRAG
CDH1_MMP9 ATG12_TKT_CDH1 ATG12_CDH1_HMGB2_SESN3
ID2_RPS19BP1 BNIP3_ID2_HMGB2 LC3_CDH1_ID2_AGER
ID2_TCF3 E2F1_ID2_HMGB2 ATG12_CDH1_HMGB2_SIRT1
CSE1L_CDH1 ATG12_CDH1_MMP9 ATG12_E2F1_CDH1_ID2
AIFM1_CDH1 ATG12_CDH1_SESN2 ATG12_FAS_CDH1_ID2
ID2_SESN3 CDH1_ID2_CDH2 AIFM1_ATG3_LC3_CDH1
ID2_SESN2 AKT1_CDH1_ID2 ATG12_CDH1_HMGB2_MMP2
LAMP1_CDH1 LAMP1_ID2_BECN1 BNIP3_CDH1_ID2_HMGB2
AIFM1_LC3 CDH1_ID2_TCF3 ATG12_ULK1_CDH1_HMGB2
E2F1_CDH1 ATG12_CDH1_UVRAG TKT_CDH1_ID2_HMGB2
ID2_NAMPT ATG12_FAS_CDH1 ATG12_CDH1_ID2_LAMP2
DIABLO_CDH1 LAMP1_TKT_ID2 ATG12_LC3_CDH1_ID2
BNIP3_CDH1 LAMP1_ID2_AGER ATG12_CDH1_HMGB2_UVRAG
AKT1_CDH1 DRAM_LAMP1_ID2 CASP8_CDH1_ID2_HMGB2
CASP8_CDH1 ATG12_DIABLO_CDH1 DIABLO_CDH1_ID2_HMGB2
CDH1_ID2_MMP9_TCF3

[0045]五种的组合六种的组合
ATG12_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_HMGB2
ATG12_DRAM_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_AGER_BECN1_HMGB2
DRAM_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_BECN1_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_RPS19BP1
ATG12_LAMP1_CDH1_ID2_HMGB2 ATG12_LAMP1_CDH1_ID2_AGER_HMGB2
ATG12_ATG5_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_MMP9_AGER_HMGB2
ATG12_E2F1_CDH1_ID2_HMGB2 ATG12_ATG3_CDH1_ID2_AGER_HMGB2
ATG12_ATG3_CDH1_ID2_HMGB2 ATG12_LC3_CDH1_ID2_AGER_HMGB2
CDH1_ID2_AGER_BECN1_HMGB2 ATG12_BNIP3_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_HMGB2_MMP2 ATG12_CDH1_ID2_AGER_HMGB2_SIRT1
ATG12_CASP8_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_MMP2
ATG12_BNIP3_CDH1_ID2_HMGB2 ATG12_CASP8_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_MMP9_HMGB2 ATG12_CDH1_ID2_AGER_CIAP2_HMGB2
LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_ATG5_CDH1_ID2_AGER_HMGB2
ATG12_CSE1L_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_TCF3_AGER_HMGB2
LC3_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_BECN1_HMGB2
ATG12_DIABLO_CDH1_ID2_HMGB2 ATG12_FAS_CDH1_ID2_AGER_HMGB2
CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_AGER_HMGB1_HMGB2
CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_HMGB2
CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_ATG3_DRAM_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_CIAP2_HMGB2 ATG12_ATG5_DRAM_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_HMGB2_UVRAG ATG12_DIABLO_CDH1_ID2_AGER_HMGB2
ATG12_DRAM_CDH1_ID2_AGER ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2
ATG12_DRAM_CDH1_TCF3_HMGB2 ATG12_CASP8_DRAM_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_AGER_BECN1 ATG12_DRAM_CDH1_ID2_HMGB2_MMP2
ATG12_DIABLO_CDH1_BHLHE41_HMGB2 ATG12_LAMP1_CDH1_ID2_BECN1_HMGB2

[0046]ATG12_DIABLO_CDH1_HMGB2_SESN3 ATG12_CBS_CDH1_ID2_AGER_HMGB2
ATG12_FAS_CDH1_ID2_HMGB2 ATG12_DRAM_CDH1_ID2_MMP9_HMGB2
ATG3_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_UVRAG
CDH1_ID2_AGER_HMGB2_MMP2 ATG12_E2F1_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_TCF3_HMGB2 ATG12_ATG5_CDH1_ID2_BECN1_HMGB2
ATG12_CDH1_TCF3_AGER_HMGB2 ATG12_DIABLO_CDH1_CIAP2_HMGB2_SESN3
ATG12_CDH1_ID2_HMGB1_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_HMGB2
AIFM1_ATG3_CASP8_LC3_CDH1 ATG12_DRAM_E2F1_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_HMGB2_SIRT1 ATG12_DIABLO_CDH1_TCF3_HMGB2_SESN3
ATG12_CDH1_TCF3_BECN1_HMGB2 AIFM1_ATG3_ATG5_CASP8_LC3_CDH1
ATG12_DIABLO_CDH1_TCF3_BHLHE41 ATG12_BNIP3_DRAM_CDH1_ID2_HMGB2
BNIP3_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_CDH1_ID2_HMGB2_SESN3
AIFM1_CASP8_DRAM_LC3_CDH1 AIFM1_ATG3_CASP8_LC3_CDH1_MMP9
ATG12_CDH1_ID2_HMGB2_LAMP2 ATG12_ATG3_CDH1_ID2_BECN1_HMGB2
ATG12_ATG3_CDH1_TCF3_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_STAT3
ATG12_LC3_CDH1_ID2_HMGB2 ATG12_DIABLO_DRAM_CDH1_ID2_HMGB2
ATG12_TKT_CDH1_ID2_HMGB2 ATG12_DRAM_CDH1_ID2_CIAP2_HMGB2
CASP8_CDH1_ID2_AGER_HMGB2 DRAM_LAMP1_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_TCF3_BHLHE41_HMGB2 DRAM_CDH1_ID2_AGER_BECN1_HMGB2
ATG5_CDH1_ID2_AGER_HMGB2 ATG12_BNIP3_CDH1_ID2_HMGB2_MMP2
ATG12_CSE1L_CDH1_ID2_AGER ATG12_BNIP3_CDH1_ID2_BECN1_HMGB2
CDH1_ID2_AGER_HMGB2_SIRT1 ATG12_CSE1L_CDH1_ID2_BECN1_HMGB2
CDH1_ID2_AGER_CIAP2_HMGB2 LAMP1_LC3_CDH1_ID2_AGER_HMGB2
CDH1_ID2_TCF3_AGER_HMGB2 ATG12_CDH1_ID2_BECN1_HMGB2_MMP2
AIFM1_CASP8_LC3_CDH1_MMP9 DRAM_LC3_CDH1_ID2_AGER_HMGB2
ATG12_DRAM_CDH1_ID2_BECN1 ATG12_DIABLO_CDH1_BHLHE41_HMGB2_SIRT1
AIFM1_CASP8_DIABLO_LC3_CDH1 ATG12_TKT_CDH1_ID2_AGER_HMGB2
CDH1_ID2_AGER_HMGB1_HMGB2 DRAM_CDH1_ID2_MMP9_AGER_HMGB2
ATG12_CDH1_ID2_HMGB2_RPS19BP1 ATG12_CDH1_ID2_MMP9_BECN1_HMGB2
ATG12_LC3_CDH1_AGER_HMGB2 CSE1L_DRAM_CDH1_ID2_AGER_HMGB2
FAS_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_FAS_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_MMP9_TCF3 ATG12_CDH1_ID2_MMP9_TCF3_HMGB2

[0047]七种的组合八种的组合
ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_ATG3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3
ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_DRAM_CDH1_TCF3_CIAP2_HMGB2_SESN3
ATG12_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 ATG12_BNIP3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3
ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1
ATG12_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_DRAM_CDH1_TCF3_BHLHE41_HMGB2_SIRT1
ATG12_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_DIABLO_CDH1_TCF3_BECN1_CIAP2_HMGB2_SESN3
ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_LAMP1_LC3_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_LC3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1
ATG12_DRAM_LC3_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_LC3_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_DRAM_CDH1_ID2_AGER_HMGB2_SIRT1 ATG12_ATG3_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3
ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_MMP9_AGER_BECN1_HMGB2
ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 ATG12_CASP8_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3
ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1
ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_LAMP1_LC3_CDH1_ID2_AGER_HMGB2
ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_CDH1_TCF3_BECN1_BHLHE41_HMGB2_SIRT1
ATG12_DRAM_CDH1_ID2_AGER_CIAP2_HMGB2 ATG12_CSE1L_LC3_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_LAMP1_LC3_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1
ATG12_CASP8_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_TCF3_AGER_BECN1_HMGB2
ATG12_CSE1L_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SESN2_SIRT1
ATG12_BNIP3_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_ATG5_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1
ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 ATG12_ATG3_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_AGER_BECN1_HMGB2_MMP2 ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2
ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2_MMP2
ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_MMP9_AGER_HMGB2

[0048]ATG12_ATG3_CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2_RPS19BP1
ATG12_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3 ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1
ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2 ATG12_CSE1L_CDH1_ID2_MMP9_AGER_BECN1_HMGB2
ATG12_ATG3_DIABLO_CDH1_TCF3_HMGB2_SESN3 ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1
ATG12_CSE1L_LC3_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_FAS_CDH1_TCF3_BECN1_BHLHE41_HMGB2
ATG12_CSE1L_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_CSE1L_DRAM_LC3_CDH1_ID2_AGER_HMGB2
ATG12_ATG5_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2
ATG12_DRAM_CDH1_ID2_AGER_HMGB1_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_MMP2
ATG12_DRAM_LAMP1_CDH1_ID2_BECN1_HMGB2 ATG12_ATG3_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1 ATG12_CSE1L_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2
ATG12_DRAM_FAS_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1
ATG12_DIABLO_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_MMP9_AGER_HMGB2
ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2 ATG12_DRAM_FAS_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_CDH1_TCF3_BECN1_HMGB2_SESN3_SIRT1
ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2 ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2_MMP2
ATG12_ATG3_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_LC3_CDH1_ID2_MMP9_AGER_BECN1_HMGB2
ATG12_CDH1_ID2_AGER_BECN1_HMGB2_SIRT1 AIFM1_CASP8_LAMP1_CDH1_AGER_CIAP2_HMGB2_RPS19BP1
ATG12_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1 ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1
AIFM1_ATG3_CASP8_CSE1L_LC3_CDH1_MMP9 ATG12_ATG3_DIABLO_CDH1_BECN1_HMGB2_SESN3_SIRT1
ATG12_ATG3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_HMGB2_SESN3
ATG12_LC3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_FAS_CDH1_TCF3_CIAP2_HMGB2_SESN3
AIFM1_CASP8_LC3_CDH1_AGER_HMGB2_RPS19BP1 ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2_RPS19BP1
ATG12_ATG5_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_CDH1_ID2_TCF3_AGER_BECN1_HMGB2
ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_BNIP3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1
AIFM1_ATG3_ATG5_CASP8_LC3_CDH1_MMP9 ATG12_DRAM_LC3_CDH1_ID2_MMP9_AGER_HMGB2
ATG12_ATG5_DRAM_CDH1_ID2_BECN1_HMGB2 ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_RPS19BP1_SESN3
ATG12_BNIP3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2_RPS19BP1
ATG12_BNIP3_CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_LAMP1_CDH1_ID2_TCF3_AGER_BECN1_HMGB2
ATG12_CDH1_ID2_MMP9_TCF3_AGER_HMGB2 ATG12_CDH1_ID2_MMP9_TCF3_AGER_BECN1_HMGB2

[0049] 优选的是，所述组合物或试剂盒用于预测A1组的无病存活预后，并且所述基因是选自下表6所示的基因或基因的组中的一种或多种。

[0050] [表6]

[0051]一种两种的组合三种的组合四种的组合
MMP2 ID2_CDH2 FRAP1_CASP3_CDH2 FRAP1_TKT_CASP3_CDH2
ID2 FRAP1_TWIST1 ID2_CDH2_SESN3 ID2_CDH2_MMP2_SESN3
TWIST1 FRAP1_CASP3 ID2_CDH2_MMP2 CBS_ID2_CDH2_SESN3
BECN1 FRAP1_SESN1 FRAP1_CDH2_TWIST1 FRAP1_TKT_CDH2_TWIST1
BAX BAX_FRAP1 FRAP1_CDH2_SESN1 FRAP1_LC3_CASP3_CDH2
BCL2L1 FRAP1_NNMT FRAP1_NNMT_CDH2 FRAP1_NNMT_TKT_CDH2
CDH2 FRAP1_CCNG2 AIFM1_FRAP1_CDH2 ID2_CDH2_RPS19BP1_SESN3
FASLG BCL2L1_FRAP1 FRAP1_TKT_TWIST1 BAX_FRAP1_TKT_CDH2
AGER FRAP1_RAGE BAX_FRAP1_CDH2 BAX_FRAP1_LC3_CDH2
ATG12 AIFM1_FRAP1 FRAP1_LC3_TWIST1 ATG12_ID2_CDH2_SESN3
TKT BCL2_FRAP1 AKT1_ID2_CDH2 ATG12_ID2_MMP2_SESN3
FRAP1_VEGF ATG12_ID2_MMP2 FRAP1_LC3_CDH2_KIAA1967
FRAP1_PTEN FRAP1_CDH2_KIAA1967 AIFM1_FRAP1_TKT_CDH2
HMGB1_TWIST1 FRAP1_CCNG2_CDH2 FRAP1_TKT_CDH2_SESN1
ATG12_ID2 FRAP1_NNMT_MMP2 ID2_MMP2_RPS19BP1_SESN3
FRAP1_RAPTOR FRAP1_CDH2_RAGE FRAP1_CDH2_SESN1_STAT3
FRAP1_KIAA1967 BCL2L1_FRAP1_CDH2 FRAP1_LC3_CDH2_TWIST1
ID2_BECN1 FRAP1_TKT_CASP3 FRAP1_LC3_NNMT_CDH2
BECN1_SESN3 ATG12_MMP2_SESN3 FRAP1_LC3_CDH2_RAPTOR
ATG12_MMP2 FRAP1_CDH2_VEGF FRAP1_TKT_CCNG2_CDH2
CDH2_SESN3 ID2_CDH2_HMGB1 DIABLO_ID2_CDH2_SESN3
ID2_MMP2 FRAP1_PTEN_CDH2 ID2_CDH2_HMGB2_SESN3

[0052]FRAP1_XIAP CDH1_ID2_CDH2 FRAP1_TKT_CDH2_KIAA1967
AKT1_CDH2 FRAP1_CASP3_MMP2 FRAP1_LC3_CDH2_RAGE
FRAP1_PRKAA1 FRAP1_LC3_CASP3 BAX_FRAP1_TKT_MMP2
ID2_RPS19BP1 BCL2_FRAP1_CDH2 BCL2L1_FRAP1_TKT_CDH2
TKT_MMP2 BAX_FRAP1_TKT FRAP1_CASP3_CDH2_STAT3
BAX_TWIST1 FRAP1_CDH2_RAPTOR FRAP1_PTEN_TKT_CDH2
BECN1_FASLG BAX_FRAP1_LC3 FRAP1_ID2_CDH2_TWIST1
ATG12_SESN3 BAX_FRAP1_MMP2 ID2_CDH2_NAMPT_SESN3
CDH2_MMP2 FAS_ID2_CDH2 FRAP1_TKT_CDH2_VEGF
BECN1_MMP2 FRAP1_RPS19BP1_TWIST1 FRAP1_LC3_CDH2_VEGF
BAX_MMP2 FRAP1_LC3_NNMT FRAP1_NNMT_CDH2_MMP2
ID2_NAMPT FRAP1_LC3_RAGE AIFM1_FRAP1_LC3_CDH2
CASP8_ID2 FRAP1_HMGB1_TWIST1 FRAP1_LC3_PTEN_CDH2
ID2_TWIST1 FRAP1_SESN1_STAT3 FRAP1_TKT_CDH2_RAGE
MMP2_SESN3 FRAP1_TKT_SESN1 FRAP1_CDH2_HMGB1_TWIST1
AKT1_BAX ATG3_ID2_CDH2 FAS_FRAP1_CDH2_SESN1
FRAP1_TP63 FRAP1_ID2_CDH2 FRAP1_CASP3_CDH2_MMP2
BAX_LC3 FRAP1_TKT_CCNG2 DRAM_ID2_CDH2_SESN3
ATG12_FASLG FAS_FRAP1_TWIST1 LC3_HMGB1_STAT3_TWIST1
LC3_TWIST1 FRAP1_NNMT_TKT CASP8_ID2_CDH2_SESN3
AKT1_TWIST1 AIFM1_FRAP1_MMP2 FRAP1_TKT_CDH2_RAPTOR
ID2_FASLG ID2_CDH2_CIAP2 BCL2L1_FRAP1_LC3_CDH2
STAT3_TWIST1 FRAP1_LC3_VEGF FRAP1_CDH2_KIAA1967_MMP2
TKT_FASLG CDH2_MMP2_SESN3 FRAP1_TKT_CASP3_FASLG
AKT1_ATG12 ID2_CDH2_FASLG TKT_ID2_CDH2_MMP2
MMP2_NAMPT CBS_ID2_CDH2 FRAP1_NNMT_TKT_MMP2
ID2_SIRT1 FRAP1_LC3_CCNG2 FRAP1_TKT_CASP3_MMP2
ID2_AGER BCL2L1_FRAP1_TKT ID2_CDH2_CIAP2_SESN3
ATG7_TWIST1 FRAP1_ID2_TWIST1 FRAP1_CDH2_STAT3_TWIST1
AKT1_BCL2L1 AIFM1_FRAP1_LC3 CBS_FRAP1_CASP3_CDH2
BAX_TKT AIFM1_FRAP1_TKT BAX_FRAP1_CDH2_MMP2
KIAA1967_MMP2 ATG5_ID2_CDH2 ATG12_TKT_MMP2_SESN3
BCL2L1_MMP2 FRAP1_TKT_RAGE FRAP1_CDH1_CASP3_CDH2
ATG7_TP63 BCL2L1_FRAP1_MMP2 BAX_FRAP1_BECN1_CDH2
LC3_BECN1 FRAP1_CDH2_TP63 ID2_CDH2_HMGB1_MMP2
CDH1_ID2_MMP9_TCF3

[0053]五种的组合六种的组合
ID2_CDH2_MMP2_RPS19BP1_SESN3 AKT1_ATG12_FAS_CDH2_STAT3_TP63
ATG12_ID2_CDH2_MMP2_SESN3 AKT1_FAS_BECN1_CDH2_STAT3_TP63
FRAP1_LC3_CASP3_CDH2_STAT3 AKT1_FAS_CDH2_RPS19BP1_STAT3_TP63
ATG12_ID2_MMP2_RPS19BP1_SESN3 AKT1_FAS_LC3_CDH2_STAT3_TP63
AKT1_FAS_CDH2_STAT3_TP63 ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CASP3_CDH2_STAT3 AKT1_ATG12_BECN1_CDH2_STAT3_TP63
CASP8_ID2_CDH2_MMP2_SESN3 AKT1_ATG7_FAS_CDH2_RPS19BP1_TP63
FRAP1_TKT_CASP3_CDH2_FASLG ATG12_ID2_CDH2_HMGB1_MMP2_SESN3
BAX_FRAP1_LC3_TKT_CDH2 FRAP1_LC3_BECN1_CASP3_CDH2_STAT3
ID2_CDH2_HMGB2_MMP2_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_STAT3
DIABLO_ID2_CDH2_MMP2_SESN3 FRAP1_LC3_NNMT_BECN1_CDH2_STAT3
FRAP1_LAMP1_TKT_CASP3_CDH2 ID2_CDH2_HMGB2_MMP2_RPS19BP1_SESN3
CBS_ID2_CDH2_MMP2_SESN3 ATG12_ID2_CDH2_CIAP2_MMP2_SESN3
FRAP1_LC3_NNMT_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_SESN1_STAT3
FRAP1_TKT_CDH2_SESN1_STAT3 FRAP1_TKT_BECN1_CASP3_CDH2_STAT3
LC3_CDH2_HMGB1_STAT3_TWIST1 ATG12_FRAP1_ID2_CDH2_MMP2_SESN3
DRAM_ID2_CDH2_MMP2_SESN3 FAS_LC3_CDH2_HMGB1_STAT3_TWIST1
FRAP1_LC3_CDH2_SESN1_STAT3 ATG12_TKT_ID2_CDH2_MMP2_SESN3
CBS_FRAP1_TKT_CASP3_CDH2 ID2_CDH2_CIAP2_MMP2_RPS19BP1_SESN3
ID2_MMP2_NAMPT_RPS19BP1_SESN3 AKT1_CASP8_FAS_CDH2_STAT3_TP63
AKT1_ID2_CDH2_RPS19BP1_SESN3 AKT1_FAS_CASP3_CDH2_STAT3_TP63
ID2_CDH2_MMP2_NAMPT_SESN3 FAS_FRAP1_LC3_NNMT_CDH2_STAT3
AKT1_BECN1_CDH2_STAT3_TP63 FAS_FRAP1_TKT_CDH2_SESN1_STAT3

[0054]FAS_FRAP1_LC3_CDH2_RAPTOR ATG12_ID2_CDH2_MMP2_SESN3_STAT3
FRAP1_LC3_CDH2_STAT3_TWIST1 FRAP1_NNMT_TKT_BECN1_CDH2_STAT3
BAX_FRAP1_TKT_CDH2_MMP2 ATG12_FAS_FRAP1_CDH2_STAT3_TP63
FAS_FRAP1_LC3_CDH2_KIAA1967 ATG12_ATG3_ID2_CDH2_MMP2_SESN3
AKT1_ATG7_CDH2_RPS19BP1_TP63 DRAM_ID2_CDH2_MMP2_RPS19BP1_SESN3
FAS_FRAP1_LC3_CDH2_RAGE ATG12_CBS_ID2_CDH2_MMP2_SESN3
FAS_LC3_HMGB1_STAT3_TWIST1 ID2_CDH2_MMP2_RPS19BP1_SESN3_STAT3
FRAP1_LC3_TKT_CASP3_CDH2 FRAP1_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CASP3_CDH2_CIAP2 AKT1_ID2_CDH2_MMP2_RPS19BP1_SESN3
TKT_ID2_CDH2_MMP2_SESN3 FAS_FRAP1_LC3_CASP3_CDH2_STAT3
FRAP1_TKT_CDH2_KIAA1967_MMP2 ATG5_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CDH2_HMGB1_TWIST1 AKT1_FAS_CDH2_HMGB1_STAT3_TP63
BAX_FRAP1_LC3_BECN1_CDH2 CSE1L_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CDH2_STAT3_TWIST1 ATG3_ID2_CDH2_MMP2_RPS19BP1_SESN3
AKT1_ATG12_ID2_CDH2_SESN3 FRAP1_LC3_NNMT_TKT_CDH2_STAT3
BAX_FAS_FRAP1_LC3_CDH2 CBS_ID2_CDH2_MMP2_RPS19BP1_SESN3
ATG12_CBS_ID2_MMP2_SESN3 AKT1_ATG12_CDH2_HMGB1_STAT3_TP63
FAS_FRAP1_CDH2_SESN1_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR_RPS19BP1
FRAP1_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_ID2_CDH2_MMP2_SESN3
FAS_FRAP1_TKT_CDH2_SESN1 ATG12_ATG5_ID2_CDH2_MMP2_SESN3
FRAP1_LC3_CCNG2_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_STAT3_TP63
ID2_CDH2_MMP2_SESN3_UVRAG AKT1_FAS_BECN1_RPS19BP1_STAT3_TP63
ATG7_ID2_CDH2_MMP2_SESN3 FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR
ID2_CDH2_HMGB1_RPS19BP1_SESN3 FAS_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CDH2_MMP2_RAPTOR ATG12_CDH1_ID2_CDH2_MMP2_SESN3
FRAP1_LC3_BECN1_CDH2_RAPTOR FRAP1_LC3_TKT_CDH2_STAT3_TWIST1
ATG12_ID2_CDH2_FASLG_SESN3 CDH1_ID2_CDH2_MMP2_RPS19BP1_SESN3
ATG7_FRAP1_TKT_CASP3_CDH2 FAS_FRAP1_LC3_CDH2_KIAA1967_RPS19BP1
FRAP1_TKT_CASP3_CDH2_MMP2 FRAP1_LC3_CDH2_HMGB1_STAT3_TWIST1
FRAP1_LC3_CDH2_HMGB1_TWIST1 ATG12_ID2_CDH2_HMGB2_MMP2_SESN3
FRAP1_LC3_TKT_CDH2_KIAA1967 ATG12_FAS_ID2_CDH2_MMP2_SESN3
ATG7_ID2_CDH2_RPS19BP1_TP63 TKT_ID2_CDH2_MMP2_RPS19BP1_SESN3
BAX_FRAP1_TKT_BECN1_CDH2 BAX_FAS_FRAP1_LC3_TKT_CDH2
ATG3_FRAP1_TKT_CASP3_CDH2 ATG12_ID2_CDH2_MMP2_RPS19BP1_SESN3
CDH1_ID2_MMP9_TCF3_CDH2 CDH1_ID2_MMP9_TCF3_CDH2_SESN3

[0055]七种的组合八种的组合
AKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63
AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63
AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63
AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63
AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63
AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63
AKT1_ATG12_FAS_CASP3_CDH2_STAT3_TP63 AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63
AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_LAMP1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_CDH2_HMGB2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63
AIFM1_AKT1_ATG12_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_CDH2_CIAP2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_KIAA1967_STAT3_TP63
AKT1_ATG12_FAS_CDH2_SESN2_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RAPTOR_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_NNMT_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63
AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_BCL2L1_FAS_BECN1_CDH2_STAT3_TP63
AKT1_ATG12_FAS_CDH2_NAMPT_STAT3_TP63 AKT1_CASP8_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63
AKT1_ATG12_FAS_CDH2_SIRT1_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_LC3_CDH2_STAT3_TP63
AKT1_FAS_LC3_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_LC3_CDH2_STAT3_TP63
AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RAPTOR_RPS19BP1_STAT3_TP63
AKT1_ATG12_DRAM_FAS_CDH2_STAT3_TP63 AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_NNMT_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_BECN1_RPS19BP1_STAT3_TP63AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63
AKT1_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_CDH2_HMGB1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63

[0056]ATG12_FAS_FRAP1_LC3_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_LAMP1_CDH2_STAT3_TP63
AKT1_ATG12_FAS_XIAP_CDH2_STAT3_TP63 AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63
AKT1_ATG12_FAS_CDH2_LAMP2_STAT3_TP63 AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63
AKT1_ATG12_ATG3_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63
AKT1_ATG12_FAS_PTEN_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63
AKT1_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH1_BECN1_CDH2_STAT3_TP63
AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_TP63 AKT1_CASP8_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63
AKT1_FAS_LC3_CDH2_HMGB1_STAT3_TP63 AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_TKT_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_CIAP2_RPS19BP1_STAT3_TP63
FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 AKT1_FAS_CDH2_HMGB1_HMGB2_RPS19BP1_STAT3_TP63
AKT1_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CASP3_CDH2_STAT3_TP63
AKT1_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63
FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTOR AKT1_ATG12_E2F1_FAS_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_E2F1_FAS_CDH2_STAT3_TP63 AKT1_ATG12_DRAM_FAS_CDH2_RPS19BP1_STAT3_TP63
AKT1_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63 AKT1_FAS_CASP3_CDH2_RPS19BP1_SESN2_STAT3_TP63
AKT1_FAS_NNMT_BECN1_CDH2_STAT3_TP63 AKT1_FAS_CDH2_HMGB2_RPS19BP1_SESN2_STAT3_TP63
AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CASP3_CDH2_RPS19BP1_STAT3_TP63
AKT1_FAS_BECN1_CDH2_LAMP2_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63
FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 AKT1_FAS_TKT_CDH2_RPS19BP1_SESN2_STAT3_TP63
FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 AKT1_ATG12_ATG3_FAS_CDH2_RPS19BP1_STAT3_TP63
ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3 AKT1_ATG12_FAS_XIAP_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_CDH2_RAPTOR_STAT3_TP63 AKT1_ATG12_CASP8_FAS_NNMT_CDH2_STAT3_TP63
FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_CASP8_FAS_CASP3_CDH2_STAT3_TP63
FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1 AKT1_ATG12_FAS_CDH2_RPS19BP1_SIRT1_STAT3_TP63
FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 AKT1_ATG12_BCL2L1_FAS_CDH2_RPS19BP1_STAT3_TP63
AKT1_FAS_TKT_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_HMGB2_STAT3_TP63
AKT1_CASP8_FAS_LC3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_NNMT_CDH2_STAT3_TP63
AKT1_FAS_LC3_CASP3_CDH2_STAT3_TP63 AIFM1_AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63
AKT1_FAS_LAMP1_BECN1_CDH2_STAT3_TP63 AKT1_ATG7_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_TP63 AKT1_ATG12_FAS_PTEN_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_TCF3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_CDH2_RPS19BP1_STAT3_TP63
AKT1_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_CIAP2_STAT3_TP63
CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3 AKT1_CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3

[0057] 优选的是，所述组合物或试剂盒用于预测A2组的复发预后，并且所述基因是选自下表7所示的基因或基因的组中的一种或多种。

[0058] [表7]

[0059]一种两种的组合三种的组合四种的组合
TKT PRKAA1_LAMP2 LC3_SESN2_SIRT1 ATG5_LC3_SESN2_SIRT1
SESN2 TKT_SESN2 BNIP3_PRKAA1_LAMP2 ATG3_LC3_SESN2_SIRT1
LAMP2 ATG7_LAMP2 ATG5_LC3_SESN2 CSE1L_LC3_SESN2_SIRT1
LAMP2_SESN2 BNIP3_LC3_SESN2 ATG5_CSE1L_LC3_SESN2
AKT1_PRKAA1 ATG7_LC3_SESN2 BNIP3_LC3_SESN2_SIRT1
SESN2_SIRT1 AKT1_PRKAA1_LAMP2 FRAP1_LC3_SESN2_SIRT1
TKT_VEGF ATG7_TKT_SESN2 AKT1_ATG3_PRKAA1_LAMP2
ATG7_TKT DRAM_LC3_SESN2 ATG3_ATG5_LC3_SESN2
TKT_LAMP2 PRKAA1_AGER_LAMP2 ATG7_LC3_SESN2_SIRT1
BHLHE41_SESN2 PRKAA1_TKT_LAMP2 BNIP3_CSE1L_LC3_SESN2
TKT_BHLHE41 ATG7_TKT_LAMP2 TKT_LAMP2_SESN2_SIRT1
ATG5_SESN2 TKT_LAMP2_SESN2 CIAP2_LAMP2_SESN2_SIRT1
LAMP1_SESN2 TKT_LAMP2_VEGF ATG12_TKT_LAMP2_SESN2
CSE1L_LAMP2 ATG12_LC3_SESN2 ATG7_TKT_LAMP2_SESN2
ATG12_SESN2 ATG7_LAMP2_SESN2 AKT1_ATG7_PRKAA1_LAMP2
AKT1_TKT TKT_SESN2_SIRT1 ATG5_BNIP3_LC3_SESN2
E2F1_SESN2 E2F1_LC3_SESN2 ATG3_BNIP3_LC3_SESN2
ATG3_LAMP2 LC3_SESN2_UVRAG AKT1_PRKAA1_LAMP2_UVRAG
BNIP3_SESN2 PRKAA1_CCNG2_LAMP2 DRAM_LC3_SESN2_SIRT1

[0060]LC3_SESN2 AKT1_ATG7_TKT ATG7_CSE1L_LC3_SESN2
TWIST1_VEGF ATG5_PRKAA1_LAMP2 ATG7_FRAP1_LC3_SESN2
ATG7_LC3 ATG3_LAMP2_SESN2 BNIP3_PRKAA1_LAMP2_SESN2
CSE1L_SESN2 BNIP3_TKT_SESN2 ATG5_ATG7_LC3_SESN2
ATG5_LC3 LAMP2_SESN2_SIRT1 PRKAA1_TKT_LAMP2_SESN2
ATG7_SESN2 ATG7_PRKAA1_LAMP2 ATG3_ATG7_LC3_SESN2
LC3_ULK1 LAMP1_LC3_SESN2 BNIP3_PRKAA1_AGER_LAMP2
ATG3_TKT ATG12_PRKAA1_LAMP2 E2F1_LC3_SESN2_SIRT1
DRAM_SESN2 CASP8_PRKAA1_LAMP2 LC3_ID2_SESN2_SIRT1
PRKAA1_TKT AIFM1_TKT_SESN2 LC3_NAMPT_SESN2_SIRT1
BHLHE41_LAMP2 FRAP1_SESN2_SIRT1 ATG5_FRAP1_LC3_SESN2
LAMP2_VEGF PRKAA1_HMGB1_LAMP2 ATG7_BNIP3_LC3_SESN2
AKT1_VEGF LC3_BHLHE41_SESN2 LC3_RPS19BP1_SESN2_SIRT1
TKT_CIAP2 ATG12_TKT_SESN2 AKT1_ATG7_TKT_SESN2
CSE1L_BHLHE41 CSE1L_LAMP2_SESN2 BCL2L1_BNIP3_PRKAA1_LAMP2
LC3_BHLHE41 PRKAA1_CASP3_LAMP2 CSE1L_DRAM_LC3_SESN2
LC3_SIRT1 PRKAA1_LAMP2_RAGE DIABLO_LC3_SESN2_SIRT1
CSE1L_LAMP1 PRKAA1_LAMP2_SESN2 LC3_SESN2_SIRT1_STAT3
TKT_RPS19BP1 TKT_CIAP2_SESN2 ATG12_ATG5_LC3_SESN2
CBS_TKT BCL2L1_PRKAA1_LAMP2 BNIP3_PRKAA1_TCF3_LAMP2
CSE1L_BECN1 DIABLO_PRKAA1_LAMP2 LC3_SESN2_SIRT1_UVRAG
TKT_CDH1 PRKAA1_CDH1_LAMP2 BNIP3_PRKAA1_MMP9_LAMP2
TKT_HMGB1 CBS_PRKAA1_LAMP2 AKT1_LC3_SESN2_SIRT1
TKT_RAGE CSE1L_SESN2_SIRT1 AKT1_PRKAA1_CDH1_LAMP2
AIFM1_SESN2 ATG3_PRKAA1_LAMP2 CSE1L_LAMP1_LC3_SESN2
ATG7_TWIST1 PRKAA1_FASLG_LAMP2 ATG7_PRKAA1_TKT_LAMP2
BHLHE41_NAMPT PRKAA1_ID2_LAMP2 KIAA1967_LAMP2_SESN2_SIRT1
BNIP3_LC3 PRKAA1_LAMP2_SATB1 LC3_SESN2_SESN3_SIRT1
PRKAA1_SESN2 PRKAA1_LAMP2_SESN1 BNIP3_PRKAA1_HMGB1_LAMP2
ATG7_NAMPT AKT1_ATG7_PTEN CSE1L_LC3_SESN2_UVRAG
BECN1_SESN2 ATG7_TKT_BHLHE41 LC3_MMP9_SESN2_SIRT1
TKT_HMGB2 PRKAA1_LAMP2_MMP2 ATG3_LAMP2_SESN2_SIRT1
TKT_SIRT1 CSE1L_LAMP1_SESN2 BNIP3_PRKAA1_CCNG2_LAMP2
ATG5_CSE1L PRKAA1_LAMP2_SESN3 BNIP3_PRKAA1_LAMP2_SATB1
SESN2_UVRAG ATG3_TKT_SESN2 BNIP3_PRKAA1_LAMP2_SESN1
TKT_CASP3 ATG5_CSE1L_SESN2 ATG5_DRAM_LC3_SESN2
TKT_CDH2 ATG5_CSE1L_LC3 BNIP3_PRKAA1_CASP3_LAMP2
TKT_MMP2 FRAP1_PRKAA1_LAMP2 BNIP3_FRAP1_LC3_SESN2

[0061]五种的组合六种的组合
CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG5_LC3_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_FRAP1_LC3_SESN2_SIRT1 NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG7_FRAP1_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
TKT_CIAP2_LAMP2_SESN2_SIRT1 AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_FRAP1_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SESN1_SESN2_SIRT1
ATG5_BNIP3_LC3_SESN2_SIRT1 CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1
TKT_CDH1_LAMP2_SESN2_SIRT1 CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
CSE1L_FRAP1_LC3_SESN2_SIRT1 AKT1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_BNIP3_LC3_SESN2_SIRT1 ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_CSE1L_LC3_SESN2_SIRT1 FAS_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_LC3_LAMP2_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1
BNIP3_FRAP1_LC3_SESN2_SIRT1 TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
BNIP3_PRKAA1_TKT_LAMP2_SESN2 ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1
ATG12_TKT_LAMP2_SESN2_SIRT1 ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_ATG7_LC3_SESN2_SIRT1 BCL2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG7_BNIP3_TKT_LAMP2_SESN2 CIAP2_FASLG_LAMP2_RAGE_SESN2_SIRT1
AKT1_ATG7_BNIP3_PRKAA1_LAMP2 ATG5_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG7_LC3_SESN2_SIRT1 CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG5_BNIP3_LC3_SESN2 FRAP1_CIAP2_FASLG_LAMP2_SESN2_SIRT1

[0062]BNIP3_CSE1L_LC3_SESN2_SIRT1 MMP9_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_DRAM_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1
AIFM1_CIAP2_LAMP2_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC3_SESN2_SIRT1
ATG7_TKT_LAMP2_SESN2_SIRT1 CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_CSE1L_FRAP1_LC3_SESN2 LAMP1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG7_LC3_NAMPT_SESN2_SIRT1 TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_E2F1_LC3_SESN2_SIRT1 ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1
BNIP3_CSE1L_FRAP1_LC3_SESN2 ATG3_ATG7_LC3_LAMP2_SESN2_SIRT1
ATG7_LC3_LAMP2_SESN2_SIRT1 ATG3_BNIP3_FRAP1_LC3_SESN2_SIRT1
AIFM1_BNIP3_PRKAA1_LAMP2_SESN2 ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1
ATG12_BNIP3_TKT_LAMP2_SESN2 ATG3_ATG5_BNIP3_LC3_SESN2_SIRT1
CIAP2_KIAA1967_LAMP2_SESN2_SIRT1 E2F1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG12_ATG5_BNIP3_LC3_SESN2 ATG3_BNIP3_LC3_LAMP2_SESN2_SIRT1
ATG3_ATG7_LC3_LAMP2_SESN2 ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1
ATG12_TKT_CIAP2_LAMP2_SESN2 ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1
ATG5_BNIP3_CSE1L_LC3_SESN2 TKT_CDH1_CIAP2_LAMP2_SESN2_SIRT1
AKT1_ATG7_PRKAA1_TKT_LAMP2 ATG5_BNIP3_E2F1_LC3_SESN2_SIRT1
ATG3_LC3_NAMPT_SESN2_SIRT1 ATG3_ATG7_LC3_NAMPT_SESN2_SIRT1
ATG3_CSE1L_LC3_SESN2_SIRT1 AIFM1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG7_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG5_LC3_ID2_SESN2_SIRT1 CBS_TKT_CIAP2_LAMP2_SESN2_SIRT1
BNIP3_E2F1_LC3_SESN2_SIRT1 ATG3_ATG5_LC3_ID2_SESN2_SIRT1
ATG3_LC3_ID2_SESN2_SIRT1 AIFM1_TKT_CIAP2_LAMP2_SESN2_SIRT1
ATG7_CSE1L_FRAP1_LC3_SESN2 ATG3_DRAM_FRAP1_LC3_SESN2_SIRT1
AIFM1_TKT_LAMP2_SESN2_SIRT1 ATG3_ATG5_E2F1_LC3_SESN2_SIRT1
LC3_CIAP2_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_LAMP2_SESN2_SIRT1
ATG12_TKT_CDH1_LAMP2_SESN2 ATG3_ATG5_LC3_SESN2_SIRT1_STAT3
ATG5_LC3_SESN2_SIRT1_STAT3 AIFM1_AKT1_LAMP2_SESN2_SIRT1_UVRAG
ATG3_DRAM_LC3_SESN2_SIRT1 AKT1_ATG7_TKT_LAMP2_SESN2_SIRT1
ATG5_DIABLO_LC3_SESN2_SIRT1 ATG3_ATG5_LC3_NAMPT_SESN2_SIRT1
ATG7_BNIP3_LC3_SESN2_SIRT1 ATG3_ATG5_DIABLO_LC3_SESN2_SIRT1
CDH2_CIAP2_LAMP2_SESN2_SIRT1 TKT_CDH1_HMGB1_LAMP2_SESN2_SIRT1
ATG3_ATG5_FRAP1_LC3_SESN2 ATG3_ATG5_LC3_LAMP2_SESN2_SIRT1
DRAM_TKT_LAMP2_SESN2_SIRT1 ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1
ATG12_ATG3_TKT_LAMP2_SESN2 BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG3_LC3_SESN2_SIRT1_STAT3 AKT1_ATG3_ATG5_LC3_SESN2_SIRT1
ATG5_LC3_SESN2_SIRT1_UVRAG AIFM1_BNIP3_PRKAA1_TKT_LAMP2_SESN2
TKT_CDH1_ID2_MMP9_TCF3_SESN2

[0063]七种的组合八种的组合
ATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_ID2_FASLG_LAMP2_SESN2_SIRT1
MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 ATG5_FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1
LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN2_SIRT1
LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1
FAS_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
CIAP2_FASLG_LAMP2_NAMPT_SESN1_SESN2_SIRT1 ATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1_STAT3
CIAP2_FASLG_LAMP2_MMP2_SESN1_SESN2_SIRT1 NNMT_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 FRAP1_AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
LC3_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN1_SESN2_SIRT1
ATG5_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1
LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 TCF3_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 TCF3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SATB1_SESN2_SIRT1

[0064]AKT1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FAS_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 NNMT_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
CCNG2_CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1 ATG3_ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1
NNMT_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 AKT1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1
NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 FRAP1_LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1
AGER_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 FRAP1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
BCL2_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_ID2_FASLG_LAMP2_SESN2_SIRT1
BCL2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1_STAT3
ULK1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN1_SESN2_SIRT1
LC3_CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1
LC3_CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_BECN1_FASLG_LAMP2_SESN2_SIRT1
AKT1_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC3_FASLG_LAMP2_SESN2_SIRT1
FRAP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 NNMT_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
FRAP1_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SESN3_SIRT1
CASP3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
CIAP2_FASLG_HMGB1_LAMP2_SESN1_SESN2_SIRT1 FAS_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1
CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN1_SESN2_SIRT1
ATG5_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SATB1_SESN2_SIRT1
ID2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BCL2_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
TCF3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ULK1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
FAS_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN2_SIRT1
LAMP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BCL2_FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1 AKT1_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
TCF3_CIAP2_FASLG_LAMP2_SESN1_SESN2_SIRT1 ATG7_BNIP3_LC3_MMP9_FASLG_LAMP2_SESN2_SIRT1
FRAP1_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 MMP9_AGER_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 FRAP1_LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
AKT1_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1
NNMT_ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CASP3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CDH2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
MMP9_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1
BNIP3_PRKAA1_CDH1_ID2_MMP9_TCF3_LAMP2 TKT_CDH1_ID2_MMP9_TCF3_LAMP2_SESN2_SIRT1

[0065] 优选的是，所述组合物或试剂盒用于预测A2组的存活预后，并且所述基因是选自下表8所示的基因或基因的组中的一种或多种。

[0066] [表8]

[0067]一种两种的组合三种的组合四种的组合
BCL2L1 BCL2L1_NNMT BCL2L1_NNMT_PRKAA1 ATG3_BCL2L1_NNMT_PRKAA1
FAS BCL2L1_E2F1 BCL2L1_E2F1_PRKAA1 BCL2L1_TKT_CASP3_SESN2
LAMP1 BCL2L1_TKT ATG3_BCL2L1_PRKAA1 BCL2L1_ID2_CASP3_SESN2
BHLHE41 FAS_LAMP1 ATG3_BCL2L1_NNMT ATG3_BCL2L1_E2F1_PRKAA1
TKT BCL2L1_PRKAA1 ATG3_BCL2L1_E2F1 BCL2L1_NNMT_PRKAA1_HMGB1
LC3 FAS_BHLHE41 FAS_BHLHE41_SESN2 BCL2L1_NNMT_PRKAA1_MMP2
SESN2 FAS_TKT BCL2L1_PRKAA1_HMGB2 BCL2L1_NNMT_PRKAA1_CDH1
BCL2L1_CASP3 BCL2L1_CASP3_SESN2 FAS_TKT_CASP3_SESN2
ATG3_BCL2L1 BCL2L1_PRKAA1_TKT BCL2L1_NNMT_PRKAA1_VEGF
ATG7_BCL2L1 FAS_CASP3_SESN2 ATG7_BCL2L1_NNMT_PRKAA1
FAS_CASP3 BCL2L1_TKT_CASP3 BCL2L1_FRAP1_NNMT_PRKAA1
TKT_BHLHE41 FAS_TKT_CASP3 BCL2L1_NNMT_PRKAA1_ID2
BCL2L1_KIAA1967 BCL2L1_E2F1_TKT AIFM1_BCL2L1_NNMT_PRKAA1
FAS_PRKAA1 BCL2L1_NNMT_TKT BCL2L1_TKT_BHLHE41_CASP3
FAS_KIAA1967 FAS_TKT_BHLHE41 BCL2L1_NNMT_PRKAA1_CDH2
FAS_SESN2 FAS_TKT_SESN2 BCL2L1_CSE1L_NNMT_PRKAA1

[0068]BCL2L1_HMGB2 FAS_LAMP1_BHLHE41 BCL2L1_NNMT_PRKAA1_HMGB2
BCL2L1_VEGF FAS_LAMP1_SESN2 BCL2L1_CBS_NNMT_PRKAA1
BNIP3_FAS ATG3_BCL2L1_TKT FAS_TKT_SESN2_TP63
FAS_TWIST1 ATG7_BCL2L1_PRKAA1 BCL2L1_DRAM_NNMT_PRKAA1
BNIP3_TKT DIABLO_FAS_BHLHE41 BCL2L1_NNMT_PRKAA1_ULK1
BCL2L1_CSE1L TKT_SESN2_TP63 BNIP3_TKT_CASP3_SESN2
TKT_SESN2 FAS_PRKAA1_TKT ATG5_BCL2L1_NNMT_PRKAA1
BCL2L1_FRAP1 ATG7_BCL2L1_NNMT BCL2L1_DIABLO_NNMT_PRKAA1
LAMP1_SESN2 BCL2L1_BNIP3_TKT BCL2L1_NNMT_CASP3_SESN2
LC3_BHLHE41 BNIP3_FAS_TKT FAS_TKT_BHLHE41_CASP3
BCL2L1_BNIP3 BCL2L1_NNMT_CASP3 BCL2L1_NNMT_PRKAA1_TKT
BCL2L1_LC3 TKT_BHLHE41_CASP3 BNIP3_FAS_TKT_CASP3
ATG5_BCL2L1 ATG3_BCL2L1_CASP3 ATG3_ATG7_BCL2L1_PRKAA1
BCL2L1_CBS BCL2L1_PRKAA1_CASP3 FAS_ID2_CASP3_SESN2
CSE1L_LAMP1 BCL2L1_PRKAA1_MMP2 BCL2L1_NNMT_PRKAA1_CASP3
E2F1_FAS FAS_BHLHE41_CASP3 ATG3_BCL2L1_PRKAA1_HMGB2
AIFM1_BCL2L1 FAS_TKT_KIAA1967 FAS_LC3_BHLHE41_SESN2
BHLHE41_SESN2 FAS_TKT_TWIST1 ATG3_BCL2L1_BNIP3_NNMT
CASP8_FAS BCL2L1_E2F1_NNMT BCL2L1_CASP8_NNMT_PRKAA1
FAS_NAMPT BCL2L1_FRAP1_NNMT FAS_BHLHE41_CASP3_SESN2
FAS_TP63 BCL2L1_TKT_BHLHE41 BCL2L1_BNIP3_NNMT_TKT
LAMP1_BHLHE41 BCL2L1_TKT_SESN2 DIABLO_FAS_BHLHE41_SESN2
ATG12_FAS FAS_KIAA1967_SESN2 ATG3_BCL2L1_PRKAA1_TKT
BCL2L1_MMP2 DIABLO_FAS_LAMP1 BCL2L1_NNMT_PRKAA1_MMP9
BHLHE41_CASP3 ATG3_BCL2L1_KIAA1967 BNIP3_FAS_CASP3_SESN2
FAS_HMGB1 ATG7_BCL2L1_E2F1 FAS_LAMP1_BHLHE41_SESN2
FAS_VEGF FAS_BHLHE41_SATB1 BCL2L1_CASP3_SESN1_SESN2
LAMP1_TCF3 ATG3_ATG7_BCL2L1 BCL2L1_NNMT_PRKAA1_SIRT1
BCL2L1_ULK1 ATG7_BCL2L1_TKT DIABLO_FAS_LAMP1_BHLHE41
FAS_LC3 BCL2L1_BNIP3_NNMT FAS_TKT_CASP3_SIRT1
NNMT_BHLHE41 BCL2L1_PRKAA1_VEGF E2F1_FAS_BHLHE41_SESN2
BCL2L1_FAS BCL2L1_BHLHE41_CASP3 FAS_TKT_CASP3_FASLG
TKT_TP63 FAS_SESN2_TP63 FAS_TKT_HMGB1_SESN2
AKT1_BCL2L1 TKT_BHLHE41_TP63 FAS_CASP3_HMGB1_SESN2
ATG12_BCL2L1 AIFM1_BCL2L1_NNMT BAX_BCL2L1_NNMT_PRKAA1
FAS_HMGB2 BCL2L1_CSE1L_NNMT BCL2L1_E2F1_NNMT_PRKAA1
BCL2L1_ID2 BCL2L1_E2F1_FRAP1 ATG3_BCL2L1_PRKAA1_MMP2
BCL2L1_RPS19BP1 BNIP3_FAS_CASP3 FAS_TKT_KIAA1967_SESN2
TKT_SATB1 FAS_TKT_SATB1 BNIP3_FAS_TKT_TWIST1
FAS_XIAP BCL2L1_CSE1L_PRKAA1 ATG3_BCL2L1_BNIP3_TKT
BCL2_BCL2L1 BCL2L1_NNMT_VEGF BCL2L1_NNMT_PRKAA1_PTEN

[0069]五种的组合六种的组合
BCL2L1_NNMT_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2
BCL2L1_PTEN_TKT_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_HMGB1 ATG3_BCL2L1_NNMT_PRKAA1_CASP3_SIRT1
BCL2L1_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_SESN1_SESN2
BCL2L1_TKT_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_ID2 BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2
BCL2L1_BNIP3_TKT_CASP3_SESN2 FAS_TKT_CASP3_HMGB1_SESN2_TP63
ATG3_BCL2L1_NNMT_PRKAA1_CDH1 ATG3_BCL2L1_NNMT_PRKAA1_KIAA1967_SIRT1
BCL2L1_TKT_CASP3_RAGE_SESN2 ATG3_BCL2L1_NNMT_ID2_CASP3_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_ULK1 ATG3_BCL2L1_NNMT_PRKAA1_HMGB1_VEGF
FAS_TKT_CASP3_HMGB1_SESN2 BCL2L1_PTEN_TKT_CASP3_SESN1_SESN2
FAS_TKT_CASP3_SESN2_TP63 BCL2L1_NNMT_ID2_AGER_CASP3_SESN2
ATG3_BCL2L1_FRAP1_NNMT_PRKAA1 BCL2L1_NNMT_ID2_BECN1_CASP3_SESN2
FAS_TKT_HMGB1_SESN2_TP63 BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN2
AIFM1_ATG3_BCL2L1_NNMT_PRKAA1 BCL2L1_PTEN_TKT_XIAP_CASP3_SESN2
BCL2L1_ID2_CASP3_SESN1_SESN2 ATG12_BCL2L1_NNMT_ID2_CASP3_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_MMP2 BNIP3_TKT_XIAP_CASP3_RAGE_SESN2

[0070]BCL2L1_TKT_CASP3_SESN1_SESN2 BCL2L1_NNMT_ID2_CASP3_CCNG2_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_VEGF AIFM1_BCL2L1_NNMT_ID2_CASP3_SESN2
BCL2L1_TKT_ID2_CASP3_SESN2 BCL2L1_PTEN_TKT_CASP3_RAGE_SESN2
ATG3_BCL2L1_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_CDH2_SESN2
BNIP3_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_LAMP2_SESN2
BCL2L1_NNMT_PRKAA1_ID2_SESN2 ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_FASLG
BCL2L1_NNMT_PRKAA1_HMGB1_VEGF BCL2L1_NNMT_ID2_CASP3_SESN2_SESN3
ATG3_BCL2L1_NNMT_PRKAA1_CDH2 BCL2L1_CSE1L_NNMT_ID2_CASP3_SESN2
ATG3_BCL2L1_LAMP1_NNMT_PRKAA1 BAX_BCL2L1_NNMT_ID2_CASP3_SESN2
BCL2L1_NNMT_ID2_SESN2_UVRAG BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2
ATG3_ATG7_BCL2L1_NNMT_PRKAA1 BCL2L1_NNMT_ID2_CASP3_MMP2_SESN2
ATG3_BCL2L1_CBS_NNMT_PRKAA1 BNIP3_PTEN_TKT_XIAP_CASP3_SESN2
BCL2L1_ID2_CASP3_RPS19BP1_SESN2 BCL2L1_BNIP3_TKT_ID2_CASP3_SESN2
BNIP3_FAS_TKT_CASP3_SESN2 BCL2L1_BNIP3_TKT_CASP3_SESN1_SESN2
ATG3_BCL2L1_DRAM_NNMT_PRKAA1 ATG3_ATG7_BCL2L1_NNMT_PRKAA1_HMGB1
ATG7_BCL2L1_NNMT_PRKAA1_HMGB1 BCL2L1_CASP8_NNMT_ID2_CASP3_SESN2
BCL2L1_NNMT_PRKAA1_HMGB1_HMGB2 ATG5_BCL2L1_NNMT_ID2_CASP3_SESN2
BCL2L1_FAS_TKT_CASP3_SESN2 BCL2L1_NNMT_CDH1_ID2_CASP3_SESN2
ATG3_BCL2L1_CSE1L_NNMT_PRKAA1 ATG3_BCL2L1_NNMT_PRKAA1_ID2_VEGF
ATG3_BCL2L1_DIABLO_NNMT_PRKAA1 BCL2L1_NNMT_PRKAA1_ID2_CASP3_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_SIRT1 BCL2L1_TKT_XIAP_CASP3_SESN1_SESN2
BCL2L1_CASP8_ID2_CASP3_SESN2 BCL2L1_NNMT_XIAP_ID2_CASP3_SESN2
BCL2L1_DIABLO_ID2_CASP3_SESN2 BCL2L1_DIABLO_NNMT_ID2_CASP3_SESN2
BCL2L1_TKT_CASP3_SESN2_STAT3 BCL2L1_TKT_XIAP_CASP3_HMGB1_SESN2
BCL2L1_NNMT_PRKAA1_ID2_VEGF BCL2L1_BNIP3_TKT_CASP3_RAGE_SESN2
BCL2L1_ID2_CASP3_HMGB2_SESN2 BCL2L1_TKT_BHLHE41_CASP3_SESN1_SESN2
BCL2L1_TKT_CASP3_SESN2_SESN3 BCL2L1_TKT_CASP3_HMGB1_RAGE_SESN2
BCL2L1_TKT_CASP3_CCNG2_SESN2 BCL2L1_PTEN_TKT_CASP3_CCNG2_SESN2
FAS_TKT_CASP3_FASLG_SESN2 BCL2L1_PRKAA1_TKT_XIAP_CASP3_SESN2
FAS_TKT_CASP3_SESN2_SIRT1 BCL2L1_TKT_CASP3_HMGB1_SESN1_SESN2
BCL2L1_NNMT_ID2_KIAA1967_SESN2 BNIP3_FAS_TKT_CASP3_HMGB1_SESN2
ATG5_BCL2L1_ID2_CASP3_SESN2 FAS_TKT_XIAP_CASP3_HMGB1_SESN2
BCL2L1_NNMT_PRKAA1_CASP3_SIRT1 BCL2L1_NNMT_ID2_SESN1_SESN2_UVRAG
BCL2L1_TKT_XIAP_BHLHE41_CASP3 FAS_TKT_HMGB1_KIAA1967_SESN2_TP63
FAS_TKT_XIAP_CASP3_SESN2 BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN2
BCL2L1_CDH1_ID2_CASP3_SESN2 BCL2L1_PTEN_TKT_ID2_CASP3_SESN2
BCL2L1_TKT_CASP3_SESN2_SIRT1 BCL2L1_ID2_CASP3_RAGE_RPS19BP1_SESN2
ATG7_BCL2L1_NNMT_PRKAA1_ID2 BNIP3_TKT_XIAP_CASP3_HMGB1_SESN2
BCL2_BCL2L1_TKT_CASP3_SESN2 ATG3_ATG7_BCL2L1_NNMT_PRKAA1_ID2
BCL2L1_ID2_CASP3_CDH2_SESN2 BCL2L1_BNIP3_NNMT_TKT_CASP3_SESN2

[0071]七种的组合八种的组合
BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_PTEN_XIAP_ID2_CASP3_SESN2
BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_SESN3
BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2
BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2
ATG3_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2_SESN3
BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2
BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN1_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_ID2_CASP3_SIRT1 BCL2_BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2
BCL2L1_CASP8_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_RAGE_SESN2
BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN2 BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN1_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_HMGB1_SESN2
BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_ID2_CASP3_SESN2
BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_RAGE_SESN2
BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2_SESN3 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2_SESN3
BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN1_SESN2
BNIP3_PTEN_TKT_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN1_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_XIAP_CASP3_SIRT1 BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_RPS19BP1_SESN2
BCL2L1_BNIP3_NNMT_TKT_XIAP_CASP3_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2
BCL2_BCL2L1_TKT_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3

[0072]ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG BCL2L1_NNMT_ID2_BHLHE41_CASP3_HMGB1_SESN1_SESN2
ATG3_BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2 ATG3_BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2
BCL2L1_NNMT_PRKAA1_ID2_CASP3_RAGE_SESN2 ATG5_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2
BCL2L1_PRKAA1_TKT_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_MMP2_SESN2
BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2 BCL2L1_BNIP3_TKT_XIAP_CASP3_RAGE_RPS19BP1_SESN2
BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2_SESN3
ATG3_BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_MMP2_SESN2
BCL2L1_BNIP3_NNMT_TKT_ID2_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CCNG2_SESN2
BCL2L1_NNMT_ID2_CASP3_HMGB1_RAGE_SESN2 BCL2_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2
BCL2L1_PRKAA1_TKT_XIAP_CASP3_RAGE_SESN2 ATG5_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2
BCL2L1_PRKAA1_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2
BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_AGER_CASP3_SESN2
BCL2L1_TKT_BHLHE41_CASP3_RAGE_SESN1_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN1_SESN2
BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_LAMP2_SESN2
BCL2L1_NNMT_ID2_BECN1_CASP3_RAGE_SESN2 BCL2L1_BNIP3_NNMT_TKT_XIAP_ID2_CASP3_SESN2
BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_SESN2 ATG12_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2
BNIP3_TKT_XIAP_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_BECN1_CASP3_SESN2
BCL2L1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_CDH2_SESN2
BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN1_SESN2 AIFM1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2
BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN2 ATG12_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2
AIFM1_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 BAX_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2
BCL2L1_NNMT_ID2_CASP3_CDH2_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_LAMP2_SESN2
BCL2L1_NNMT_CDH1_ID2_CASP3_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_AGER_CASP3_SESN2
BCL2L1_NNMT_ID2_AGER_CASP3_RAGE_SESN2 AKT1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2
BNIP3_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 BAX_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2
BNIP3_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_PTEN_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2
BNIP3_TKT_XIAP_CASP3_HMGB1_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_BECN1_CASP3_SESN2
BCL2L1_NNMT_ID2_CASP3_MMP2_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CDH2_SESN2
ATG5_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 BCL2L1_CASP8_NNMT_ID2CASP3_HMGB1_RAGE_SESN2
BCL2L1_BNIP3_TKT_ID2_CASP3_RPS19BP1_SESN2 BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN1_SESN2
BCL2L1_NNMT_ID2_CASP3_RAGE_SESN1_SESN2 ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG_KIAA1967
BCL2L1_NNMT_TKT_ID2_BHLHE41_CASP3_SESN2 BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2_SESN3
BCL2L1_PTEN_TKT_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_CSE1L_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2
BCL2L1_CSE1L_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_STAT3
BCL2L1_PTEN_TKT_CASP3_RAGE_SESN1_SESN2 BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2
BNIP3_TKT_XIAP_CASP3_CCNG2_RAGE_SESN2 BCL2L1_NNMT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3
ATG3_BCL2L1_BNIP3_TKT_CASP3_FASLG_SESN2 BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN1_SESN2
BCL2L1_BNIP3_E2F1_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_ID2_HMGB1_HMGB2_SESN1_SESN2
BCL2L1_CDH1_ID2_MMP9_TCF3_CASP3_SESN2 BCL2L1_TKT_CDH1_ID2_MMP9_TCF3_CASP3_SESN2

[0073] 优选的是，所述组合物或试剂盒用于预测A2组的无病存活预后，并且所述基因是选自下表9所示的基因或基因的组中的一种或多种。

[0074] [表9]

[0075]一种两种的组合三种的组合四种的组合
SESN2 TKT_SESN2 ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SESN2
TKT BHLHE41_SESN2 FRAP1_SESN2_SIRT1 CSE1L_FRAP1_SESN2_SIRT1
LAMP2 LAMP2_SESN2 ATG5_LC3_SESN2 ATG7_TKT_LAMP2_SESN2
BHLHE41 ATG5_SESN2 ATG5_FRAP1_SESN2 ATG5_FRAP1_SESN2_SIRT1
CSE1L LAMP1_SESN2 TKT_LAMP2_SESN2 AKT1_ATG7_TKT_SESN2
SESN2_SIRT1 AIFM1_TKT_SESN2 ATG5_CSE1L_LC3_SESN2
E2F1_SESN2 ATG5_CSE1L_SESN2 FRAP1_LC3_SESN2_SIRT1
ATG12_SESN2 LC3_SESN2_SIRT1 CSE1L_FRAP1_LAMP1_SESN2
TKT_VEGF ATG12_TKT_SESN2 ATG7_TKT_SESN2_SESN3
CSE1L_BECN1 CSE1L_LAMP1_SESN2 ATG5_FRAP1_LC3_SESN2
CSE1L_SESN2 TKT_HMGB2_SESN2 ATG7_CSE1L_FRAP1_SESN2
ATG7_TKT ATG5_TKT_SESN2 CSE1L_LC3_SESN2_SIRT1
FASLG_SESN2 TKT_CDH1_SESN2 ATG5_LC3_SESN2_SIRT1
PRKAA1_LAMP2 TKT_SESN2_SESN3 ATG7_TKT_FASLG_SESN2

[0076]PRKAA1_SESN2 TKT_SESN2_VEGF ATG7_TKT_AGER_SESN2
TKT_BHLHE41 CSE1L_BHLHE41_SESN2 ATG7_TKT_HMGB1_SESN2
CSE1L_BHLHE41 PRKAA1_TKT_SESN2 ATG7_TKT_MMP2_SESN2
ATG7_SESN2 ATG3_TKT_SESN2 BNIP3_CSE1L_FRAP1_SESN2
CSE1L_LAMP2 TKT_RPS19BP1_SESN2 ATG5_ATG7_TKT_SESN2
FAS_SESN2 CBS_TKT_SESN2 ATG7_BCL2_TKT_SESN2
HMGB2_SESN2 CSE1L_LAMP2_SESN2 ATG7_BNIP3_TKT_SESN2
CSE1L_LAMP1 TKT_SESN2_SIRT1 FAS_FRAP1_SESN2_SIRT1
BECN1_SESN2 AKT1_TKT_SESN2 AIFM1_ATG7_TKT_SESN2
NNMT_SESN2 CSE1L_SESN2_SIRT1 ATG12_TKT_LAMP2_SESN2
AIFM1_SESN2 TKT_CDH2_SESN2 ATG7_TKT_BHLHE41_SESN2
BAX_SESN2 BNIP3_TKT_SESN2 ATG7_TKT_ID2_SESN2
DRAM_SESN2 NNMT_TKT_SESN2 CSE1L_DRAM_FRAP1_SESN2
CSE1L_ULK1 TKT_AGER_SESN2 CSE1L_FRAP1_SESN2_UVRAG
KIAA1967_SESN2 TKT_BHLHE41_SESN2 ATG7_LAMP1_TKT_SESN2
SESN2_VEGF TKT_HMGB1_SESN2 ATG7_BCL2L1_TKT_SESN2
BNIP3_SESN2 TKT_MMP2_SESN2 ATG7_TKT_CCNG2_SESN2
SESN2_UVRAG E2F1_TKT_SESN2 CSE1L_E2F1_FRAP1_SESN2
TWIST1_VEGF NAMPT_SESN2_SIRT1 CSE1L_LAMP1_LC3_SESN2
PRKAA1_FASLG TKT_KIAA1967_SESN2 PRKAA1_TKT_LAMP2_SESN2
TKT_RPS19BP1 DRAM_TKT_SESN2 ATG7_CBS_TKT_SESN2
PRKAA1_TKT TKT_CIAP2_SESN2 ATG7_LC3_TKT_SESN2
ATG7_LAMP2 TKT_MMP9_SESN2 ATG7_NNMT_TKT_SESN2
AGER_SESN2 ATG5_NAMPT_SESN2 ATG7_TKT_CIAP2_SESN2
CDH2_SESN2 ATG7_FRAP1_SESN2 ATG7_TKT_SESN2_STAT3
AKT1_PRKAA1 CSE1L_E2F1_SESN2 ATG7_PTEN_TKT_SESN2
ULK1_SESN2 LAMP1_TKT_SESN2 ATG7_TKT_CASP3_SESN2
MMP2_SESN2 LC3_TKT_SESN2 ATG7_TKT_CDH2_SESN2
ATG5_CSE1L TKT_CASP3_SESN2 ATG7_TKT_HMGB2_SESN2
HMGB1_SESN2 TKT_CCNG2_SESN2 ATG7_TKT_NAMPT_SESN2
AKT1_TKT TKT_ID2_SESN2 ATG7_TKT_RAPTOR_SESN2
CBS_SESN2 TKT_RAPTOR_SESN2 ATG7_TKT_SESN2_SIRT1
FRAP1_SESN2 TKT_XIAP_SESN2 ATG7_FRAP1_LC3_SESN2
CIAP2_SESN2 BAX_TKT_SESN2 ATG7_TKT_BECN1_SESN2
BCL2_SESN2 BCL2_TKT_SESN2 ATG7_DIABLO_TKT_SESN2
CCNG2_SESN2 ATG12_CSE1L_SESN2 ATG7_FRAP1_SESN2_SIRT1
BCL2L1_SESN2 BCL2L1_TKT_SESN2 ATG12_CSE1L_FRAP1_SESN2
CSE1L_UVRAG CASP8_TKT_SESN2 ATG7_TKT_XIAP_SESN2
RAPTOR_SESN2 DIABLO_TKT_SESN2 ATG7_E2F1_TKT_SESN2
XIAP_SESN2 FAS_BHLHE41_SESN2 ATG7_TKT_MMP9_SESN2
CASP3_SESN2 FRAP1_TKT_SESN2 ATG7_TKT_RAGE_SESN2
CASP8_SESN2 PTEN_TKT_SESN2 ATG3_ATG7_TKT_SESN2
LC3_SESN2 TKT_RAGE_SESN2 ATG7_CSE1L_LC3_SESN2

[0077]五种的组合六种的组合
ATG5_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1
CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1
ATG5_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_FRAP1_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2
ATG7_CSE1L_FRAP1_LC3_SESN2 ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG7_FRAP1_LC3_SESN2_SIRT1 ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_FRAP1_LAMP1_SESN2 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2
AKT1_ATG7_TKT_LAMP2_SESN2 ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1
ATG5_FRAP1_LAMP1_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2
CSE1L_FRAP1_LAMP1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1
ATG3_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2
AKT1_ATG5_CSE1L_FRAP1_SESN2 ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1
ATG5_CSE1L_DIABLO_FRAP1_SESN2 ATG5_CSE1L_FRAP1_LC3_ID2_SESN2
ATG5_CSE1L_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3
CSE1L_FRAP1_SESN2_SIRT1_UVRAG CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG7_TKT_LAMP2_SESN2_SESN3 AKT1_CSE1L_FRAP1_LC3_SESN2_SIRT1

[0078]CSE1L_FRAP1_SATB1_SESN2_SIRT1 ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1
CSE1L_FRAP1_CDH1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG7_TKT_FASLG_LAMP2_SESN2 ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG5_CSE1L_FRAP1_ID2_SESN2 CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1
AKT1_ATG7_TKT_SESN2_SESN3 CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1
ATG7_TKT_LAMP2_MMP2_SESN2 CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1
AKT1_CSE1L_FRAP1_SESN2_SIRT1 AKT1_ATG5_FRAP1_LC3_SESN2_SIRT1
BNIP3_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2
ATG5_CSE1L_FRAP1_SESN2_SESN3 ATG5_FRAP1_LC3_ID2_SESN2_SIRT1
CSE1L_FRAP1_LAMP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LAMP1_SESN2_SIRT1
ATG3_ATG5_CSE1L_FRAP1_SESN2 ATG3_ATG7_FRAP1_LC3_SESN2_SIRT1
CSE1L_DRAM_FRAP1_LC3_SESN2 ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1
ATG3_CSE1L_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LAMP1_LC3_SESN2
ATG5_ATG7_FRAP1_LC3_SESN2 ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2
ATG5_FAS_FRAP1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3
CSE1L_FRAP1_SESN2_SESN3_SIRT1 BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1
CSE1L_DRAM_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_SESN2_SIRT1_UVRAG
CSE1L_DIABLO_FRAP1_SESN2_SIRT1 ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2
ATG7_CSE1L_FRAP1_SESN2_SIRT1 ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1
ATG5_CSE1L_FRAP1_CDH1_SESN2 ATG5_ATG7_FRAP1_LAMP1_SESN2_SIRT1
ATG7_TKT_FASLG_SESN2_SESN3 ATG5_CSE1L_FRAP1_CDH1_SESN2_SIRT1
ATG7_TKT_HMGB1_LAMP2_SESN2 ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3
ATG7_TKT_AGER_LAMP2_SESN2 ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2
ATG3_ATG5_FRAP1_LC3_SESN2 ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG3_ATG5_FRAP1_SESN2_SIRT1 ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_FRAP1_SATB1_SESN2 ATG3_ATG5_FRAP1_LAMP1_SESN2_SIRT1
CSE1L_FRAP1_ID2_SESN2_SIRT1 CSE1L_FRAP1_LC3_CDH1_SESN2_SIRT1
ATG7_BNIP3_TKT_LAMP2_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_STAT3
ATG5_ATG7_CSE1L_FRAP1_SESN2 AIFM1_ATG12_TKT_FASLG_LAMP2_SESN2
ATG5_LC3_NAMPT_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_UVRAG
ATG12_ATG5_CSE1L_FRAP1_SESN2 CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1
CSE1L_FRAP1_SESN2_SIRT1_STAT3 CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1
CSE1L_FRAP1_LC3_SESN2_UVRAG ATG5_CSE1L_FRAP1_LC3_RPS19BP1_SESN2
AKT1_ATG7_TKT_MMP2_SESN2 AKT1_ATG5_CSE1L_FRAP1_SESN2_SIRT1
ATG5_BNIP3_CSE1L_FRAP1_SESN2 ATG5_CSE1L_E2F1_FRAP1_LC3_SESN2
CSE1L_FRAP1_MMP9_SESN2_SIRT1 CSE1L_E2F1_FRAP1_LC3_SESN2_SIRT1
BNIP3_CSE1L_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2
AKT1_ATG7_TKT_HMGB1_SESN2 ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2
AIFM1_AKT1_ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SATB1_SESN2_SIRT1
AKT1_ATG5_ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SESN2_SESN3_SIRT1
ATG12_ATG7_TKT_LAMP2_SESN2 ATG7_TKT_FASLG_LAMP2_SESN2_SIRT1
CDH1_ID2_MMP9_TCF3_SESN2 TKT_CDH1_ID2_MMP9_TCF3_SESN2

[0079]七种的组合八种的组合
ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3
ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_FASLG_HMGB1_LAMP2_SESN2
ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1
AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1
ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG3_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1
ATG3_ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1_UVRAG
AKT1_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1

[0080]ATG3_ATG5_FRAP1_LC3_ID2_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_CIAP2_FASLG_LAMP2_SESN2
ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2
ATG5_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG
AIFM1_ATG12_TKT_CDH1_FASLG_LAMP2_SESN2 ATG3_ATG5_CSE1L_DRAM_FRAP1_LC3SESN2_SIRT1
ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1_UVRAG
ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3 AKT1_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1
AKT1_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1 AIFM1_ATG12_NNMT_CDH2_CIAP2_FASLG_LAMP2_SESN2
ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG3_ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1
ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SESN3_SIRT1
ATG3_ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG3_ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_AGER_FASLG_LAMP2_SESN2
ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_ID2SESN2_SIRT1_UVRAG
ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1
AIFM1_ATG12_TKT_CIAP2_FASLG_LAMP2_SESN2 ATG3_ATG5_ATG7_FRAP1_LAMP1_LC3_SESN2_SIRT1
ATG5_CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1 AKT1_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1
ATG3_ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1
ATG7_TKT_FASLG_LAMP2_SESN2_SESN3_SIRT1 AIFM1_DRAM_TKT_CDH1_FASLG_LAMP2_SESN2_SIRT1
ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1
ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SATB1_SESN2_SIRT1
ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_ID2_SATB1_SESN2_SIRT1
ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3
AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG12_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SESN3_SIRT1
AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG5_ATG7_FRAP1_LC3_RPS19BP1_SESN2_SIRT1ATG5_CSE1L_DRAM_FRAP1_LC3_SATB1_SESN2_SIRT1
ATG3_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1
ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3
ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1
ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 AIFM1_DRAM_TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1
AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 ATG5_ATG7_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1
ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2 ATG3_ATG5_DIABLO_DRAM_FRAP1_LC3_SESN2_SIRT1
ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3 ATG5_ATG7_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1
AKT1_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_MMP9_AGER_FASLG_LAMP2_SESN2_SIRT1
AKT1_ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1
ATG7_TKT_CDH1_ID2MMP9_TCF3_SESN2 TKT_CDH1_ID2_MMP9_TCF3_FASLG_SESN2_SIRT1

[0081] 优选的是，所述组合物或试剂盒用于预测B组的复发预后，并且所述基因是选自下表10所示的基因或基因的组中的一种或多种。

[0082] [表10]

[0083]一种两种的组合三种的组合四种的组合
HMGB1 ATG3_HMGB1 ATG3_BCL2_HMGB1 ATG3_BCL2_CDH1_HMGB1
TKT ATG3_BECN1 ATG3_HMGB1_RAGE ATG3_CDH1_HMGB1_UVRAG
TKT_HMGB1 ATG3_TKT_HMGB1 ATG3_BCL2_TKT_HMGB1
BCL2L1_TKT ATG3_CDH1_HMGB1 ATG3_BCL2_HMGB1_RAGE
ATG3_NAMPT ATG3_HMGB1_HMGB2 ATG3_BCL2_HMGB1_HMGB2
BCL2_HMGB1 ATG3_HMGB1_UVRAG ATG3_CDH1_HMGB1_SIRT1
HMGB1_TWIST1 ATG3_CASP3_HMGB1 ATG3_BCL2_HMGB1_MMP2
ATG12_ATG3 ATG3_HMGB1_SIRT1 ATG3_HMGB1_HMGB2_RAGE
CSE1L_DIABLO ATG3_BECN1_SATB1 ATG3_BCL2_BNIP3_HMGB1
ATG3_TKT ATG3_HMGB1_SATB1 ATG3_CDH1_CASP3_HMGB1
LAMP1_HMGB1 ATG3_LC3_BECN1 ATG3_CDH1_HMGB1_KIAA1967
TKT_BECN1 ATG3_HMGB1_LAMP2 ATG3_HMGB1_RAGE_UVRAG

[0084]CDH1_HMGB1 ATG3_HMGB1_RAPTOR ATG3_HMGB1_RAGE_SIRT1
HMGB1_TP63 ATG3_HMGB1_KIAA1967 ATG3_TKT_HMGB1_HMGB2
TKT_NAMPT BCL2L1_TKT_CASP3 ATG3_TKT_HMGB1_UVRAG
BCL2_TKT ATG12_ATG3_HMGB1 ATG3_BCL2_LAMP1_HMGB1
CSE1L_TKT BCL2L1_TKT_SIRT1 ATG3_BCL2_HMGB1_RAPTOR
LC3_TKT ATG3_CIAP2_HMGB1 AIFM1_ATG3_BCL2_HMGB1
TKT_CASP3 BCL2L1_TKT_BECN1 ATG3_CASP3_HMGB1_RAGE
FASLG_HMGB1 BCL2_TKT_HMGB1 ATG12_ATG3_HMGB1_RAGE
CDH2_HMGB1 ATG3_BECN1_SESN3 ATG3_TKT_CASP3_HMGB1
ATG5_HMGB1 ATG3_CASP8_HMGB1 ATG3_TKT_HMGB1_KIAA1967
HMGB1_SIRT1 ATG3_CDH2_HMGB1 ATG3_BCL2L1_TKT_BECN1
ATG12_HMGB1 ATG3_FRAP1_HMGB1 ATG12_ATG3_CDH1_HMGB1
HMGB1_RAGE ATG3_BNIP3_HMGB1 ATG3_CDH1_HMGB1_RAGE
HMGB1_UVRAG ATG3_BECN1_HMGB1 ATG3_BCL2_FRAP1_HMGB1
BCL2L1_SIRT1 ATG3_CBS_HMGB1 ATG3_BCL2_HMGB1_LAMP2
ATG3_TCF3 AIFM1_ATG3_HMGB1 ATG3_BCL2_DIABLO_HMGB1
BCL2L1_HMGB1 ATG3_HMGB1_STAT3 ATG3_TKT_HMGB1_SIRT1
TKT_SIRT1 ATG3_HMGB1_MMP2 ATG3_BCL2_CBS_HMGB1
HMGB1_LAMP2 ATG3_LAMP1_HMGB1 ATG3_BCL2_CASP8_HMGB1
TKT_SESN2 BCL2L1_TKT_FASLG ATG3_HMGB1_HMGB2_SATB1
HMGB1_MMP2 ATG3_DIABLO_HMGB1 ATG3_BCL2_PTEN_HMGB1
TKT_AGER BCL2_BCL2L1_TKT ATG3_HMGB1_RAGE_RAPTOR
HMGB1_RAPTOR TKT_HMGB1_TWIST1 ATG3_TKT_HMGB1_RAGE
E2F1_HMGB1 ATG3_NNMT_HMGB1 ATG3_BCL2_CASP3_HMGB1
CASP8_HMGB1 ATG3_MMP9_HMGB1 ATG3_BCL2_HMGB1_SATB1
TKT_ID2 BCL2L1_TKT_HMGB1 ATG3_HMGB1_LAMP2_RAGE
AKT1_TKT ATG3_LAMP1_BECN1 ATG3_CDH1_HMGB1_LAMP2
ATG3_SIRT1 ATG3_BCL2L1_BECN1 ATG3_HMGB1_HMGB2_UVRAG
TKT_RPS19BP1 ATG5_TKT_HMGB1 ATG3_BCL2L1_TKT_HMGB1
CSE1L_HMGB1 ATG3_FASLG_HMGB1 CDH1_HMGB1_TP63_UVRAG
BCL2L1_BECN1 ATG3_MMP9_BECN1 ATG3_CDH1_HMGB1_HMGB2
CASP3_HMGB1 ATG3_ATG7_BECN1 ATG3_BCL2L1_TKT_CASP3
ATG7_HMGB1 ATG3_HMGB1_SESN3 ATG3_HMGB1_KIAA1967_RAGE
FRAP1_HMGB1 ATG3_E2F1_HMGB1 ATG3_BCL2_DRAM_HMGB1
HMGB1_HMGB2 HMGB1_RAPTOR_TWIST1 ATG3_LC3_TKT_HMGB1
HMGB1_SATB1 AKT1_ATG3_BECN1 ATG3_BCL2_HMGB1_UVRAG
ATG3_ULK1 ATG3_FAS_HMGB1 ATG3_CDH1_CDH2_HMGB1
ATG3_SESN1 ATG3_ULK1_HMGB1 BCL2_BCL2L1_TKT_CASP3
CBS_HMGB1 TKT_HMGB1_SIRT1 ATG3_TKT_BECN1_HMGB1
TKT_KIAA1967 ATG3_BAX_HMGB1 ATG3_TKT_HMGB1_LAMP2
ATG12_BCL2L1 TKT_CDH2_HMGB1 ATG3_BCL2_PRKAA1_HMGB1
DRAM_HMGB1 ATG3_PTEN_HMGB1 BCL2L1_TKT_CASP3_SIRT1
LC3_FASLG ATG3_TKT_BECN1 BCL2L1_TKT_CASP3_FASLG
HMGB1_KIAA1967 ATG3_HMGB1_TWIST1 BCL2L1_TKT_CASP3_CDH2
TKT_SESN1 BCL2L1_TKT_UVRAG ATG3_BCL2_NNMT_HMGB1

[0085]五种的组合六种的组合
ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR
ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE
ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE
ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE
ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR
ATG3_BCL2_BNIP3_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE
ATG3_BCL2_CDH1_HMGB1_LAMP2 ATG3_BCL2_CDH1_HMGB1_RAGE_UVRAG
ATG3_BCL2_CDH1_CDH2_HMGB1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE
ATG3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_CASP3_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG
ATG12_ATG3_BCL2_CDH1_HMGB1 ATG12_ATG3_BCL2_CDH1_HMGB1_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_UVRAG
ATG3_BCL2_CASP8_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAGE

[0086]ATG3_BCL2_FRAP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2
ATG3_BCL2_CBS_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2
ATG3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1
ATG3_BCL2_TKT_HMGB1_HMGB2 AIFM1_ATG3_BCL2_CDH1_HMGB1_UVRAG
ATG3_BCL2_CDH1_HMGB1_MMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967
ATG3_BCL2_NNMT_CDH1_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2
ATG3_BCL2_HMGB1_HMGB2_RAGE ATG12_ATG3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_CDH1_MMP9_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAPTOR
ATG12_ATG3_CDH1_HMGB1_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_SIRT1
ATG3_CDH1_HMGB1_LAMP2_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2
ATG3_BCL2_DIABLO_CDH1_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE
ATG3_BCL2L1_TKT_BECN1_CASP3 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967
ATG3_BCL2_HMGB1_MMP2_RAGE ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE
ATG3_CDH1_HMGB1_HMGB2_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2
ATG3_BCL2_DRAM_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_SIRT1
ATG3_BCL2_TKT_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_UVRAG
ATG3_BCL2_TKT_CASP3_HMGB1 ATG3_BCL2_CASP8_CDH1_HMGB1_RAGE
ATG3_CDH1_HMGB1_KIAA1967_UVRAG ATG3_CDH1_HMGB1_LAMP2_RAGE_SIRT1
ATG3_CDH1_HMGB1_LAMP2_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_UVRAG
ATG3_BCL2_BCL2L1_TKT_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_SATB1 ATG3_BCL2_BCL2L1_TKT_HMGB1_SIRT1
ATG3_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_SIRT1
ATG3_BCL2_TKT_ID2_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_RAGE
ATG3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967
ATG3_BCL2_PTEN_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAPTOR
AIFM1_ATG3_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_RAGE_SIRT1_UVRAG
ATG3_BCL2_CDH1_HMGB1_STAT3 ATG3_BCL2_CBS_CDH1_HMGB1_RAGE
ATG3_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_UVRAG
ATG3_BCL2_LC3_TKT_HMGB1 ATG3_BCL2_CBS_CDH1_HMGB1_UVRAG
ATG3_CDH1_CASP3_HMGB1_UVRAG ATG3_CDH1_HMGB1_HMGB2_RAGE_SIRT1
ATG3_BCL2_CDH1_CIAP2_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAPTOR
ATG3_BCL2_BNIP3_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAPTOR
ATG3_CDH1_HMGB1_RAPTOR_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3
ATG3_CDH1_HMGB1_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_RAPTOR_UVRAG
ATG3_CDH1_HMGB1_RAPTOR_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2
ATG3_CDH1_HMGB1_KIAA1967_SIRT1 ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2
ATG3_BAX_BCL2_CDH1_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_SIRT1
ATG3_BCL2_LAMP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_SIRT1
ATG3_ATG5_BCL2_CDH1_HMGB1 AIFM1_ATG3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_TKT_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2
ATG3_CDH1_HMGB1_SATB1_UVRAG ATG3_BCL2_CBS_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_SESN3 ATG3_BCL2_CASP8_CDH1_HMGB1_UVRAG
ATG3_BCL2_FAS_CDH1_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_UVRAG
CDH1_ID2_MMP9_TCF3_FASLG ATG12_ATG3_CDH1_ID2_MMP9_TCF3

[0087]七种的组合八种的组合
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2
ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAG
ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967
ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1
AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGE
ATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGE
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1 AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_KIAA1967_TWIST1
ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1
ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR

[0088]ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGE ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGE
ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2CASP3_HMGB2_UVRAG
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967 ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_TWIST1
ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_HMGB2_SIRT1
AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGE
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1
ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAPTOR
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE
ATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGE ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_KIAA1967
AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTOR
ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGE
AIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1
ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAG
ATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_RAGE
ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_LAMP2
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_UVRAG
ATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1
ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_KIAA1967
AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_LC3_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG
AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_SIRT1
ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_UVRAG
ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTOR AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1
ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGE ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_UVRAG ATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1 ATG3_LC3_TKT_HMGB1_KIAA1967_RAGE_TWIST1_UVRAG
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_KIAA1967
AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR
ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE
ATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTOR
ATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_UVRAG
ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1
ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_UVRAG
ATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGE ATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGE
ATG12_ATG3_CDH1_ID2_MMP9_TCF3_SATB1 ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG

[0089] 优选的是，所述组合物或试剂盒用于预测B组的存活预后，并且所述基因是选自下表11所示的基因或基因的组中的一种或多种。

[0090] [表11]

[0091]一种两种的组合三种的组合四种的组合
ATG12 DIABLO_NAMPT DIABLO_ID2_NAMPT ATG12_ID2_MMP9_TCF3
DIABLO ATG12_ID2 DIABLO_FAS_NAMPT DIABLO_FAS_ID2_NAMPT
UVRAG ATG12_RPS19BP1 ATG12_ID2_TCF3 ATG12_CSE1L_ID2_MMP9
NAMPT ATG12_DIABLO DIABLO_FAS_STAT3 DIABLO_ID2_MMP9_NAMPT
STAT3 ID2_NAMPT ATG12_ID2_MMP9 DIABLO_FAS_MMP9_NAMPT
E2F1 DIABLO_STAT3 ATG12_ID2_SATB1 DIABLO_ID2_NAMPT_STAT3
BECN1 DIABLO_FAS ATG12_ID2_RPS19BP1 ATG12_FAS_ID2_MMP9
FRAP1 ATG12_CSE1L ATG12_CSE1L_ID2 ATG12_ID2_MMP9_SATB1
ATG7 ATG12_MMP9 ATG12_DIABLO_FAS DIABLO_ID2_NAMPT_SATB1
ID2 ATG12_ATG3 ATG12_ID2_SESN2 ATG12_ID2_MMP9_SESN2

[0092]SIRT1 ATG12_SATB1 ATG12_ID2_NAMPT ATG12_ID2_MMP9_RPS19BP1
BCL2 ATG12_SESN2 ATG12_CSE1L_DIABLO CSE1L_DIABLO_ID2_NAMPT
BNIP3 CSE1L_DIABLO ID2_NAMPT_STAT3 DIABLO_ID2_TCF3_NAMPT
LAMP2 ATG12_TCF3 ATG12_ID2_BHLHE41 DIABLO_FAS_NAMPT_SATB1
TKT ATG12_FAS CSE1L_DIABLO_NAMPT ATG12_DIABLO_FAS_MMP9
ATG12_STAT3 DIABLO_LC3_NAMPT DIABLO_FAS_ID2_STAT3
ATG12_BHLHE41 ATG12_FAS_ID2 ATG12_ATG3_ID2_TCF3
ATG12_NAMPT ID2_NAMPT_RPS19BP1 ATG3_DIABLO_ID2_NAMPT
ATG12_ATG7 ID2_MMP9_TCF3 ATG12_ID2_TCF3_STAT3
ID2_BECN1 DIABLO_NAMPT_SATB1 DIABLO_FAS_NAMPT_STAT3
E2F1_FAS ATG12_CSE1L_MMP9 ATG12_CSE1L_DIABLO_MMP9
ATG12_ATG5 ATG12_MMP9_RPS19BP1 ATG12_ID2_TCF3_SATB1
ID2_STAT3 ID2_MMP9_BECN1 DIABLO_FAS_MMP9_STAT3
ATG12_ULK1 DIABLO_NAMPT_STAT3 ATG12_ID2_MMP9_BHLHE41
DIABLO_BECN1 ATG12_DIABLO_MMP9 ATG12_BNIP3_ID2_MMP9
ATG12_LAMP1 ATG12_FAS_RPS19BP1 DIABLO_FAS_SATB1_STAT3
ATG12_LC3 DIABLO_FAS_MMP9 DIABLO_FAS_NAMPT_RPS19BP1
DIABLO_TCF3 ID2_MMP9_NAMPT ATG12_ATG3_ID2_MMP9
AKT1_ATG12 ATG12_ID2_STAT3 ATG12_ID2_MMP9_NAMPT
ATG12_FRAP1 ATG12_DIABLO_TCF3 DIABLO_FAS_NAMPT_SESN2
DIABLO_ID2 ATG12_ATG3_ID2 DIABLO_ID2_NAMPT_SESN2
ID2_TCF3 ATG12_DIABLO_ID2 ATG12_ID2_TCF3_RPS19BP1
DIABLO_SATB1 CSE1L_DIABLO_STAT3 ATG12_DIABLO_MMP9_TCF3
ATG12_BECN1 DIABLO_ID2_STAT3 ATG12_CSE1L_ID2_SATB1
ATG12_SIRT1 ATG12_ATG3_RPS19BP1 ATG12_FAS_MMP9_RPS19BP1
NAMPT_STAT3 ATG12_DIABLO_SATB1 ID2_MMP9_TCF3_STAT3
ATG12_BNIP3 ATG12_MMP9_TCF3 ATG12_DIABLO_ID2_NAMPT
DIABLO_MMP9 ATG3_DIABLO_NAMPT DIABLO_ID2_TCF3_STAT3
ATG12_UVRAG ATG12_DIABLO_NAMPT ATG12_ULK1_ID2_TCF3
DIABLO_FRAP1 ATG12_CSE1L_RPS19BP1 ATG12_ID2_TCF3_SESN2
NAMPT_RPS19BP1 DIABLO_MMP9_NAMPT BNIP3_CSE1L_DIABLO_MMP9
AKT1_NAMPT ATG12_ATG3_DIABLO ATG12_DIABLO_ID2_TCF3
E2F1_UVRAG DIABLO_SATB1_STAT3 ATG12_ATG5_ID2_MMP9
ATG3_DIABLO ID2_TCF3_STAT3 ATG12_ID2_SATB1_STAT3
NAMPT_UVRAG ATG12_RPS19BP1_SATB1 ATG12_MMP9_TCF3_RPS19BP1
BNIP3_DIABLO ATG12_DIABLO_STAT3 ATG12_DIABLO_FAS_ID2
DIABLO_LC3 ATG12_TCF3_RPS19BP1 ATG12_CSE1L_ID2_SESN2
DIABLO_SIRT1 DIABLO_NAMPT_SESN2 DIABLO_FAS_MMP9_TCF3
LC3_NAMPT ATG12_DIABLO_SESN2 ATG12_ID2_TCF3_BHLHE41
DIABLO_SESN2 ATG12_ULK1_ID2 ATG12_FAS_ID2_STAT3
FAS_STAT3 ATG12_ATG5_ID2 BNIP3_CSE1L_ID2_MMP9
FAS_NAMPT AKT1_DIABLO_NAMPT CSE1L_DIABLO_FAS_NAMPT
E2F1_NAMPT ATG12_ID2_BECN1 ATG12_CSE1L_ID2_TCF3
ATG12_SESN3 ATG12_FAS_MMP9 ATG12_ID2_NAMPT_RPS19BP1
BCL2_TKT ATG12_DIABLO_BHLHE41 ATG12_ID2_MMP9_BECN1
ATG7_NAMPT ATG12_RPS19BP1_STAT3 DIABLO_FAS_LC3_NAMPT
ATG7_BECN1 DIABLO_NAMPT_RPS19BP1 FAS_ID2_NAMPT_RPS19BP1
CDH1_ID2_MMP9_TCF3

[0093]五种的组合六种的组合
DIABLO_FAS_ID2_MMP9_NAMPT DIABLO_FAS_ID2_MMP9_TCF3_NAMPT
ATG12_ATG3_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3
ATG12_ID2_MMP9_TCF3_SATB1 ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1
ATG12_CSE1L_ID2_MMP9_TCF3 ATG12_ATG3_ID2_MMP9_TCF3_SATB1
ATG12_BNIP3_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_SATB1
ATG12_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ULK1_ID2_MMP9_TCF3
ATG12_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_CSE1L_ID2_MMP9_SESN2
ATG12_ATG5_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_STAT3
ATG12_FAS_ID2_MMP9_TCF3 ATG12_ATG3_FAS_ID2_MMP9_TCF3
DIABLO_FAS_ID2_NAMPT_STAT3 ATG12_ATG3_ID2_MMP9_TCF3_SESN2
ATG12_ID2_MMP9_TCF3_RPS19BP1 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3

[0094]ATG12_BNIP3_ID2_MMP9_RPS19BP1 CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT
ATG12_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_CSE1L_ID2_MMP9_TCF3
ATG12_CSE1L_ID2_MMP9_SESN2 ATG12_BNIP3_ID2_MMP9_TCF3_SATB1
ATG12_LAMP1_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_SESN2
DIABLO_FAS_ID2_NAMPT_SATB1 ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41
ATG12_BNIP3_CSE1L_ID2_MMP9 ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1
DIABLO_ID2_MMP9_TCF3_NAMPT DIABLO_FAS_ID2_MMP9_TCF3_STAT3
ATG12_BNIP3_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9
ATG12_ID2_MMP9_TCF3_BHLHE41 ATG12_ATG3_BNIP3_ID2_MMP9_SATB1
ATG12_ID2_MMP9_TCF3_STAT3 ATG12_BNIP3_CSE1L_ID2_MMP9_RPS19BP1
ATG12_BNIP3_FAS_ID2_MMP9 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9
ATG12_BNIP3_ID2_MMP9_SESN2 ATG12_BNIP3_FAS_ID2_MMP9_RPS19BP1
ATG12_ATG3_FAS_ID2_MMP9 ATG12_CSE1L_ID2_MMP9_TCF3_SATB1
CSE1L_DIABLO_ID2_MMP9_NAMPT ATG12_CSE1L_ULK1_ID2_MMP9_TCF3
ATG12_DIABLO_ID2_MMP9_TCF3 ATG12_FAS_ID2_MMP9_TCF3_RPS19BP1
DIABLO_ID2_NAMPT_SATB1_STAT3 DIABLO_FAS_ID2_NAMPT_SATB1_STAT3
ATG12_ATG3_CSE1L_ID2_MMP9 ATG12_ATG5_BNIP3_ID2_MMP9_TCF3
ATG12_FAS_ID2_MMP9_RPS19BP1 ATG12_BNIP3_ID2_MMP9_TCF3_SESN2
ATG12_DIABLO_FAS_ID2_MMP9 ATG12_CSE1L_ID2_MMP9_TCF3_SESN2
DIABLO_FAS_ID2_MMP9_STAT3 ATG12_ID2_MMP9_TCF3_SATB1_SESN2
ATG12_CSE1L_ID2_MMP9_BHLHE41 ATG12_ULK1_ID2_MMP9_TCF3_SATB1
DIABLO_ID2_MMP9_NAMPT_STAT3 ATG12_ATG3_ATG5_ID2_MMP9_TCF3
DIABLO_FAS_ID2_NAMPT_SESN2 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9
ATG12_CSE1L_FAS_ID2_MMP9 ATG12_ATG3_LAMP1_ID2_MMP9_TCF3
DIABLO_FAS_ID2_TCF3_NAMPT ATG12_BNIP3_DIABLO_ID2_MMP9_TCF3
ATG12_ATG3_ID2_MMP9_SATB1 ATG12_BNIP3_ULK1_ID2_MMP9_TCF3
ATG12_BNIP3_ID2_MMP9_BHLHE41 ATG12_DIABLO_FAS_ID2_MMP9_TCF3
ATG3_DIABLO_FAS_ID2_NAMPT ATG12_ULK1_ID2_MMP9_TCF3_SESN2
CSE1L_DIABLO_FAS_ID2_NAMPT ATG3_DIABLO_FAS_ID2_MMP9_NAMPT
ATG12_CSE1L_ID2_MMP9_RPS19BP1 ATG12_ATG3_BNIP3_ID2_MMP9_SESN2
ATG12_CSE1L_ULK1_ID2_MMP9 ATG12_ATG3_ID2_MMP9_TCF3_BHLHE41
DIABLO_FAS_ID2_MMP9_TCF3 ATG12_BNIP3_CSE1L_FAS_ID2_MMP9
CSE1L_DIABLO_ID2_NAMPT_STAT3 DIABLO_ID2_MMP9_TCF3_NAMPT_SATB1
ATG12_ATG3_ID2_MMP9_SESN2 ATG12_ATG3_BNIP3_ID2_MMP9_RPS19BP1
DIABLO_ID2_MMP9_TCF3_STAT3 ATG12_ATG5_ID2_MMP9_TCF3_SATB1
DIABLO_ID2_TCF3_NAMPT_SATB1 ATG12_BNIP3_FAS_ID2_MMP9_TCF3
CSE1L_DIABLO_FAS_MMP9_NAMPT ATG12_ATG3_CSE1L_ID2_MMP9_SATB1
DIABLO_FAS_ID2_NAMPT_RPS19BP1 ATG12_ATG3_ID2_MMP9_TCF3_STAT3
BNIP3_DIABLO_FAS_ID2_MMP9 ATG12_ATG5_BNIP3_ID2_MMP9_SATB1
DIABLO_ID2_MMP9_NAMPT_SATB1 ATG12_BNIP3_ID2_MMP9_TCF3_BHLHE41
ATG12_DIABLO_FAS_MMP9_TCF3 ATG12_FAS_ID2_MMP9_TCF3_SESN2
ATG12_ATG5_FAS_ID2_MMP9 DIABLO_FAS_ID2_MMP9_NAMPT_RPS19BP1
ATG12_LC3_ID2_MMP9_TCF3 ATG12_ATG3_CSE1L_ID2_MMP9_SESN2
ATG12_FAS_ID2_MMP9_STAT3 ATG12_ATG3_ID2_MMP9_TCF3_RPS19BP1
FAS_ID2_MMP9_NAMPT_RPS19BP1 ATG12_ATG5_BNIP3_FAS_ID2_MMP9
ATG12_ID2_MMP9_TCF3_BECN1 ATG12_ATG5_ULK1_ID2_MMP9_TCF3
ATG12_CDH1_ID2_MMP9_TCF3 E2F1_FAS_CDH1_ID2_MMP9_TCF3

[0095]七种的组合八种的组合
DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2
ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1
ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SESN2 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1
ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1
ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_STAT3
DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_SESN2
ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1
ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1
ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_SESN2
ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3
ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3
DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_STAT3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2

[0096]DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_STAT3 ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1
ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1
ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2
ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3 ATG3_BCL2_E2F1_LAMP1_TKT_MMP9_CASP3_HMGB1
ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2
ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_CSE1L_DIABLO_FAS_ID2_MMP9
ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41
ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_BHLHE41
ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_SATB1
ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_SATB1
ATG12_ATG3_ID2_MMP9_TCF3_SATB1_SESN2 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_SESN2
DIABLO_FAS_ID2_MMP9_TCF3_SATB1_STAT3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41_SATB1
ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1
ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9 ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_SESN2
ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1_SESN2
ATG12_BNIP3_CSE1L_DIABLO_FAS_ID2_MMP9 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_SATB1
ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SESN2 ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_SATB1
CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_STAT3 ATG12_BNIP3_FAS_ULK1_ID2_MMP9_TCF3_RPS19BP1
ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9 CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_STAT3
ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_TCF3
ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_SESN2
ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2 ATG12_ATG3_ATG5_BNIP3_ULK1_ID2_MMP9_TCF3
ATG12_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_RPS19BP1
ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_SATB1
ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SESN2
ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_SATB1
ATG12_ATG3_FAS_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_SESN2
ATG12_ATG3_FAS_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_RPS19BP1
ATG12_ATG3_FAS_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_TCF3
ATG12_ATG3_FAS_ULK1_ID2_MMP9_TCF3 ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2
ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_SATB1 ATG12_ATG5_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1
ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_RPS19BP1ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1_SESN2
ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SESN2 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3_SATB1
ATG12_ATG3_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_SESN2
ATG12_BNIP3_CSE1L_FAS_ID2_MMP9_RPS19BP1 ATG12_BNIP3_DIABLO_FAS_ULK1_ID2_MMP9_TCF3
ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_SESN2
ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41 ATG3_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1
ATG12_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2_STAT3
ATG12_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1 DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2_STAT3
DIABLO_FAS_ID2_MMP9_NAMPT_SESN2_STAT3 ATG12_ATG3_ATG5_BNIP3_CSE1L_FAS_ID2_MMP9
CSE1L_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_BHLHE41
DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_TCF3
CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_RPS19BP1
ATG12_ATG3_BNIP3_DIABLO_ID2_MMP9_TCF3 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_SATB1
ATG12_ATG3_BNIP3_FAS_ID2MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_SESN2
ATG3_TKT_CDH1_ID2_MMP9_TCF3_UVRAG ATG3_TKT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG

[0097] 优选的是，所述组合物或试剂盒用于预测B组的无病存活预后，并且所述基因是选自下表12所示的基因或基因的组中的一种或多种。

[0098] [表12]

[0099]一种两种的组合三种的组合四种的组合
DIABLO ATG3_BECN1 ATG3_BCL2_HMGB1 ATG3_BCL2_CDH1_HMGB1
BECN1 ATG3_HMGB1 ATG3_HMGB1_RAGE ATG3_CDH1_HMGB1_UVRAG
HMGB1 BCL2L1_TKT ATG3_HMGB1_UVRAG ATG3_BCL2_TKT_HMGB1
CSE1L_DIABLO ATG3_CASP3_HMGB1 ATG3_BCL2_HMGB1_RAGE
BCL2_HMGB1 ATG3_HMGB1_SIRT1 ATG3_BCL2_HMGB1_HMGB2
ATG12_ATG3 ATG3_BECN1_SATB1 ATG3_CDH1_HMGB1_SIRT1
ATG3_NAMPT ATG3_HMGB1_LAMP2 ATG3_BCL2_HMGB1_MMP2

[0100]HMGB1_TWIST1 ATG3_HMGB1_RAPTOR ATG3_HMGB1_HMGB2_RAGE
TKT_HMGB1 ATG3_LC3_BECN1 ATG3_BCL2_BNIP3_HMGB1
LAMP1_HMGB1 ATG3_HMGB1_KIAA1967 ATG3_CDH1_CASP3_HMGB1
TKT_BECN1 BCL2L1_TKT_CASP3 ATG3_CDH1_HMGB1_KIAA1967
HMGB1_TP63 ATG12_ATG3_HMGB1 ATG3_HMGB1_RAGE_UVRAG
BCL2_TKT BCL2L1_TKT_SIRT1 ATG3_HMGB1_RAGE_SIRT1
TKT_CASP3 BCL2L1_TKT_BECN1 ATG3_TKT_HMGB1_UVRAG
FASLG_HMGB1 BCL2_TKT_HMGB1 ATG3_BCL2_LAMP1_HMGB1
TKT_NAMPT ATG3_BECN1_SESN3 ATG3_BCL2_HMGB1_RAPTOR
ATG5_HMGB1 ATG3_BNIP3_HMGB1 AIFM1_ATG3_BCL2_HMGB1
HMGB1_SIRT1 ATG3_BECN1_HMGB1 ATG3_CASP3_HMGB1_RAGE
ATG12_HMGB1 AIFM1_ATG3_HMGB1 ATG12_ATG3_HMGB1_RAGE
HMGB1_RAGE ATG3_LAMP1_HMGB1 ATG3_TKT_CASP3_HMGB1
DIABLO_NAMPT BCL2L1_TKT_FASLG ATG3_TKT_HMGB1_KIAA1967
HMGB1_UVRAG BCL2_BCL2L1_TKT ATG3_BCL2L1_TKT_BECN1
DIABLO_BECN1 TKT_HMGB1_TWIST1 ATG12_ATG3_CDH1_HMGB1
BECN1_SATB1 ATG3_NNMT_HMGB1 ATG3_CDH1_HMGB1_RAGE
BCL2L1_SIRT1 BCL2L1_TKT_HMGB1 ATG3_BCL2_FRAP1_HMGB1
BCL2L1_HMGB1 ATG3_BCL2L1_BECN1 ATG3_BCL2_HMGB1_LAMP2
TKT_SIRT1 ATG5_TKT_HMGB1 ATG3_BCL2_DIABLO_HMGB1
DIABLO_TCF3 ATG3_FASLG_HMGB1 ATG3_TKT_HMGB1_SIRT1
HMGB1_LAMP2 ATG3_MMP9_BECN1 ATG3_BCL2_CBS_HMGB1
DIABLO_SATB1 ATG3_LAMP1_BECN1 ATG3_BCL2_CASP8_HMGB1
HMGB1_RAPTOR ATG3_E2F1_HMGB1 ATG3_BCL2_PTEN_HMGB1
E2F1_HMGB1 HMGB1_RAPTOR_TWIST1 ATG3_HMGB1_RAGE_RAPTOR
ATG5_BECN1 AKT1_ATG3_BECN1 ATG3_TKT_HMGB1_RAGE
ATG12_SATB1 ATG3_ULK1_HMGB1 ATG3_BCL2_CASP3_HMGB1
BCL2L1_BECN1 TKT_HMGB1_SIRT1 ATG3_BCL2_HMGB1_SATB1
CASP3_HMGB1 ATG3_BAX_HMGB1 ATG3_HMGB1_LAMP2_RAGE
ATG12_CSE1L ATG3_PTEN_HMGB1 ATG3_CDH1_HMGB1_LAMP2
ATG7_HMGB1 ATG3_TKT_HMGB1 ATG3_HMGB1_HMGB2_UVRAG
ATG3_SIRT1 ATG3_TKT_BECN1 ATG3_BCL2L1_TKT_HMGB1
CASP8_HMGB1 ATG3_HMGB1_TWIST1 CDH1_HMGB1_TP63_UVRAG
ATG3_SESN1 BCL2L1_TKT_UVRAG ATG3_BCL2L1_TKT_CASP3
TKT_KIAA1967 TKT_HMGB1_UVRAG ATG3_HMGB1_KIAA1967_RAGE
ATG12_BCL2L1 BCL2L1_TKT_CDH2 ATG3_BCL2_DRAM_HMGB1
DRAM_HMGB1 BCL2L1_TKT_KIAA1967 ATG3_BCL2_HMGB1_UVRAG
LC3_FASLG ATG3_BCL2L1_HMGB1 BCL2_BCL2L1_TKT_CASP3
HMGB1_KIAA1967 ATG3_ATG5_HMGB1 ATG3_TKT_BECN1_HMGB1
TKT_SESN1 ATG3_DRAM_HMGB1 ATG3_TKT_HMGB1_LAMP2
ATG3_DIABLO ATG3_HMGB1_SATB1 ATG3_BCL2_PRKAA1_HMGB1
DIABLO_SIRT1 ATG3_BCL2L1_TKT BCL2L1_TKT_CASP3_SIRT1
BECN1_HMGB1 ATG3_PRKAA1_HMGB1 BCL2L1_TKT_CASP3_FASLG
AIFM1_HMGB1 TKT_CASP3_HMGB1 BCL2L1_TKT_CASP3_CDH2
ID2_BECN1 ATG3_XIAP_HMGB1 ATG3_BCL2_NNMT_HMGB1
CSE1L_BECN1 TKT_HMGB1_KIAA1967 ATG3_CDH1_HMGB1_RAPTOR
TKT_ULK1 TKT_HMGB1_LAMP2 ATG3_BNIP3_HMGB1_RAGE
BNIP3_HMGB1 HMGB1_RAGE_TWIST1 ATG3_BAX_BCL2_HMGB1
TKT_UVRAG ATG12_BCL2L1_TKT ATG3_BCL2_ID2_HMGB1
ATG5_TKT ATG3_PTEN_BECN1 ATG3_BCL2_HMGB1_STAT3

[0101]五种的组合六种的组合
ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR
ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE
ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE
ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE
ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR
ATG3_BCL2_BNIP3_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE
ATG3_BCL2_CDH1_HMGB1_LAMP2 ATG3_BCL2_CDH1_HMGB1_RAGE_UVRAG
ATG3_BCL2_CDH1_CDH2_HMGB1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE

[0102]ATG3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_CASP3_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG
ATG12_ATG3_BCL2_CDH1_HMGB1 ATG12_ATG3_BCL2_CDH1_HMGB1_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_UVRAG
ATG3_BCL2_CASP8_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAGE
ATG3_BCL2_FRAP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2
ATG3_BCL2_CBS_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2
ATG3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1
ATG3_BCL2_TKT_HMGB1_HMGB2 AIFM1_ATG3_BCL2_CDH1_HMGB1_UVRAG
ATG3_BCL2_CDH1_HMGB1_MMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967
ATG3_BCL2_NNMT_CDH1_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2
ATG3_BCL2_HMGB1_HMGB2_RAGE ATG12_ATG3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_CDH1_MMP9_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAPTOR
ATG12_ATG3_CDH1_HMGB1_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_SIRT1
ATG3_CDH1_HMGB1_LAMP2_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2
ATG3_BCL2_DIABLO_CDH1_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE
ATG3_BCL2L1_TKT_BECN1_CASP3 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967
ATG3_BCL2_HMGB1_MMP2_RAGE ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE
ATG3_CDH1_HMGB1_HMGB2_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2
ATG3_BCL2_DRAM_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_SIRT1
ATG3_BCL2_TKT_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_UVRAG
ATG3_BCL2_TKT_CASP3_HMGB1 ATG3_BCL2_CASP8_CDH1_HMGB1_RAGE
ATG3_CDH1_HMGB1_KIAA1967_UVRAG ATG3_CDH1_HMGB1_LAMP2_RAGE_SIRT1
ATG3_CDH1_HMGB1_LAMP2_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_UVRAG
ATG3_BCL2_BCL2L1_TKT_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_SATB1 ATG3_BCL2_BCL2L1_TKT_HMGB1_SIRT1
ATG3_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_SIRT1
ATG3_BCL2_TKT_ID2_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_RAGE
ATG3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967
ATG3_BCL2_PTEN_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAPTOR
AIFM1_ATG3_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_RAGE_SIRT1_UVRAG
ATG3_BCL2_CDH1_HMGB1_STAT3 ATG3_BCL2_CBS_CDH1_HMGB1_RAGE
ATG3_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_UVRAG
ATG3_BCL2_LC3_TKT_HMGB1 ATG3_BCL2_CBS_CDH1_HMGB1_UVRAG
ATG3_CDH1_CASP3_HMGB1_UVRAG ATG3_CDH1_HMGB1_HMGB2_RAGE_SIRT1
ATG3_BCL2_CDH1_CIAP2_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAPTOR
ATG3_BCL2_BNIP3_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAPTOR
ATG3_CDH1_HMGB1_RAPTOR_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3
ATG3_CDH1_HMGB1_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_RAPTOR_UVRAG
ATG3_CDH1_HMGB1_RAPTOR_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2
ATG3_CDH1_HMGB1_KIAA1967_SIRT1 ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2
ATG3_BAX_BCL2_CDH1_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_SIRT1
ATG3_BCL2_LAMP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_SIRT1
ATG3_ATG5_BCL2_CDH1_HMGB1 AIFM1_ATG3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_TKT_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2
ATG3_CDH1_HMGB1_SATB1_UVRAG ATG3_BCL2_CBS_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_SESN3 ATG3_BCL2_CASP8_CDH1_HMGB1_UVRAG
ATG3_BCL2_FAS_CDH1_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_UVRAG
CDH1_ID2_MMP9_TCF3_FASLG ATG12_ATG3_CDH1_ID2_MMP9_TCF3

[0103]七种的组合八种的组合
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2
ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAG
ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967
ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1
AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGE
ATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGE
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1

[0104]ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1 AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1 ATG3_BCL2L1_TKT_ID2CDH2_HMGB2_KIAA1967_TWIST1
ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1
ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGE ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGE
ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2CASP3_HMGB2_UVRAG
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967 ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_TWIST1
ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1 ATG3_BCL2_BCL2L1_BNIP3TKT_ID2_HMGB2_SIRT1
AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGE
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1
ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAPTOR
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE
ATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGE ATG3_BCL2_BCL2L1_BNIP3TKT_ID2CASP3_KIAA1967
AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTOR
ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGE
AIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1
ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAG
ATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_RAGE
ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_LAMP2
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_UVRAG
ATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1
ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_KIAA1967
AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_LC3TKT_HMGB1_RAGE_RAPTOR_TTWIST1_UVRAG
AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_BNIP3TKT_ID2_CASP3_SIRT1
ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_UVRAG
ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTOR AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1
ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGE ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_UVRAG ATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1 ATG3_LC3TKT_HMGB1_KIAA1967_RAGE_TWIST1_UVRAG
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_KIAA1967
AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR
ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE
ATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTOR
ATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_UVRAG
ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1
ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_UVRAG
ATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGE ATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGE
NNMT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG

[0105] 优选的是，所述组合物或试剂盒用于预测C组的复发预后，并且所述基因是选自下表13所示的基因或基因的组中的一种或多种。

[0106] [表13]

[0107]一种两种的组合三种的组合四种的组合
FASLG CIAP2_FASLG FAS_LC3_FASLG DIABLO_FAS_LC3_FASLG
CIAP2 E2F1_FASLG DIABLO_FAS_FASLG FAS_LC3_FASLG_UVRAG
CSE1L LC3_FASLG E2F1_LC3_FASLG BNIP3_FAS_LC3_FASLG
FAS DIABLO_FASLG FAS_FASLG_RPS19BP1 DRAM_FAS_LC3_FASLG
TCF3 FAS_FASLG E2F1_FAS_FASLG E2F1_FAS_LC3_FASLG

[0108]FASLG_RPS19BP1 FAS_FASLG_UVRAG ATG3_FAS_LC3_FASLG
PTEN_FASLG DIABLO_LC3_FASLG ATG7_FAS_LC3_FASLG
CASP3_FASLG ATG7_FAS_FASLG FAS_LC3_FASLG_STAT3
FASLG_SESN2 CIAP2_FASLG_SESN3 FAS_FRAP1_LC3_FASLG
FASLG_HMGB1 CIAP2_FASLG_UVRAG FAS_LC3_FASLG_SESN3
CDH2_FASLG BNIP3_LC3_FASLG FAS_LC3_FASLG_SIRT1
FRAP1_FASLG LC3_CIAP2_FASLG FAS_LC3_BECN1_FASLG
ATG7_FASLG LC3_FASLG_SESN2 ATG5_FAS_LC3_FASLG
ATG3_FAS FRAP1_LC3_FASLG FAS_LC3_FASLG_RPS19BP1
FASLG_HMGB2 LC3_FASLG_SESN3 FAS_LAMP1_LC3_FASLG
FASLG_UVRAG ATG3_FAS_FASLG FAS_LC3_FASLG_NAMPT
DIABLO_FAS ATG7_LC3_FASLG AKT1_FAS_LC3_FASLG
FASLG_MMP2 FAS_FRAP1_FASLG FAS_LC3_FASLG_SESN2
TKT_FASLG DIABLO_FASLG_SESN2 FAS_LC3_MMP9_FASLG
PTEN_CIAP2 DRAM_LC3_FASLG FAS_FASLG_RPS19BP1_SESN3
FAS_LC3 CIAP2_FASLG_HMGB1 FAS_FASLG_RPS19BP1_UVRAG
CBS_FASLG FAS_FASLG_SESN3 FAS_LC3_CDH1_FASLG
AIFM1_FASLG LC3_FASLG_UVRAG ATG12_FAS_LC3_FASLG
CASP3_CIAP2 CASP3_CIAP2_FASLG DIABLO_FAS_FASLG_SESN3
FASLG_SESN3 FAS_FASLG_SESN2 DIABLO_FAS_FASLG_UVRAG
ATG3_FASLG PTEN_CIAP2_FASLG FAS_LC3_FASLG_LAMP2
CASP8_FASLG DIABLO_FASLG_SESN3 FAS_LC3_ID2_FASLG
XIAP_FASLG ATG7_CIAP2_FASLG DIABLO_FAS_FASLG_SESN2
AGER_FASLG LC3_FASLG_SIRT1 FAS_LC3_BHLHE41_FASLG
ATG3_ULK1 LC3_FASLG_RPS19BP1 DIABLO_DRAM_FAS_FASLG
BNIP3_FASLG FASLG_SESN2_SESN3 DIABLO_FAS_FASLG_STAT3
FAS_UVRAG DRAM_FAS_FASLG DRAM_FAS_FASLG_RPS19BP1
CIAP2_RAGE ID2_CIAP2_FASLG DIABLO_FAS_FRAP1_FASLG
ATG3_TCF3 FAS_FASLG_STAT3 FAS_FASLG_SESN2_UVRAG
FASLG_RAGE AKT1_CIAP2_FASLG ATG3_FAS_FASLG_SESN2
E2F1_CIAP2 DIABLO_FRAP1_FASLG ATG7_DIABLO_FAS_FASLG
FASLG_VEGF BNIP3_FAS_FASLG FAS_LC3_TCF3_FASLG
E2F1_FAS FAS_LAMP1_FASLG ATG7_FAS_FASLG_UVRAG
XIAP_CIAP2 TKT_CIAP2_FASLG DIABLO_FAS_FASLG_NAMPT
BCL2L1_FASLG ATG7_DIABLO_FASLG DIABLO_FAS_FASLG_SIRT1
BNIP3_FAS FRAP1_FASLG_SESN2 DIABLO_FAS_LAMP1_FASLG
FASLG_SESN1 E2F1_ULK1_FASLG FAS_FRAP1_FASLG_RPS19BP1
FASLG_KIAA1967 DRAM_CIAP2_FASLG CSE1L_FAS_LC3_FASLG
AIFM1_CIAP2 PTEN_CASP3_FASLG DIABLO_FAS_BECN1_FASLG
DRAM_FASLG LC3_FASLG_NAMPT E2F1_LC3_ID2_FASLG
ATG3_CIAP2 PTEN_CDH1_CIAP2 AKT1_DIABLO_FAS_FASLG
CSE1L_FASLG ATG12_CIAP2_FASLG ATG3_DIABLO_FAS_FASLG
FASLG_RAPTOR FASLG_RPS19BP1_SESN3 E2F1_FAS_FASLG_SESN3
TCF3_FASLG MMP9_CIAP2_FASLG ATG7_FAS_FASLG_SESN2
FASLG_STAT3 LAMP1_CIAP2_FASLG DIABLO_FAS_FASLG_RPS19BP1
ULK1_FASLG LC3_BECN1_FASLG DRAM_FAS_FASLG_UVRAG
PRKAA1_CIAP2 CDH1_CIAP2_FASLG LC3_MMP9_FASLG_SESN2
FASLG_SIRT1 BECN1_CIAP2_FASLG FAS_FASLG_SESN3_UVRAG
ATG12_FASLG CIAP2_FASLG_HMGB2 DIABLO_FAS_FASLG_LAMP2
LAM P1_FASLG E2F1_FASLG_LAMP2 DIABLO_FAS_ID2_FASLG
NNMT_FASLG CIAP2_FASLG_SIRT1 E2F1_LC3_FASLG_LAMP2
BCL2L1_CIAP2 PTEN_XIAP_FASLG E2F1_LC3_MMP9_FASLG
CDH1_ID2_MMP9_TCF3

[0109]五种的组合六种的组合
BNIP3_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_SESN2
DRAM_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_FASLG_SESN3
DIABLO_DRAM_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2
ATG3_FAS_LC3_FASLG_SESN3 ATG3_FAS_LC3_MMP9_FASLG_SESN3
BNIP3_FAS_LC3_FASLG_SESN3 ATG3_FAS_LC3_FASLG_SESN2_SESN3
BNIP3_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG

[0110]ATG3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_STAT3
BNIP3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_UVRAG
DRAM_FAS_LC3_FASLG_STAT3 BNIP3_DRAM_FAS_LC3_FASLG_SIRT1
DIABLO_FAS_LC3_BECN1_FASLG ATG3_DRAM_FAS_LC3_FASLG_SESN2
BNIP3_DIABLO_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_BECN1_FASLG
ATG7_DRAM_FAS_LC3_FASLG DRAM_FAS_LC3_ID2_FASLG_UVRAG
DIABLO_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_MMP9_FASLG_UVRAG
DRAM_FAS_LC3_FASLG_SIRT1 DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1
DRAM_E2F1_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_UVRAG
DRAM_FAS_LC3_FASLG_SESN3 DRAM_FAS_LC3_FASLG_SIRT1_UVRAG
DRAM_FAS_LC3_BECN1_FASLG DRAM_FAS_LC3_MMP9_FASLG_UVRAG
BNIP3_FAS_LC3_FASLG_STAT3 BNIP3_DRAM_FAS_LC3_ID2_FASLG
BNIP3_FAS_LC3_MMP9_FASLG ATG3_DRAM_FAS_LC3_FASLG_SESN3
DIABLO_FAS_LC3_ID2_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN3
DIABLO_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN2
ATG5_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_BECN1_FASLG_UVRAG
ATG5_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_FRAP1_LC3_FASLG
DIABLO_FAS_LC3_FASLG_SIRT1 BNIP3_FAS_LC3_FASLG_SESN3_SIRT1
FAS_LC3_FASLG_SIRT1_UVRAG DRAM_FAS_LC3_BHLHE41_FASLG_UVRAG
DRAM_FAS_FRAP1_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_LAMP2
DIABLO_FAS_LC3_FASLG_SESN3 AKT1_BNIP3_DRAM_FAS_LC3_FASLG
FAS_LC3_BECN1_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG
ATG3_FAS_LC3_MMP9_FASLG DRAM_FAS_LC3_FASLG_SESN3_SIRT1
BNIP3_FAS_LC3_FASLG_SIRT1 ATG3_DIABLO_FAS_LC3_MMP9_FASLG
BNIP3_FAS_FRAP1_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN3_STAT3
DIABLO_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_BECN1_FASLG_SESN2
DIABLO_FAS_LC3_FASLG_NAMPT BNIP3_FAS_LC3_FASLG_SESN2_SIRT1
FAS_LC3_MMP9_FASLG_RPS19BP1 DIABLO_DRAM_FAS_LC3_MMP9_FASLG
BNIP3_FAS_LC3_BECN1_FASLG BNIP3_FAS_LC3_BECN1_FASLG_SESN3
E2F1_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN2_UVRAG
FAS_LC3_MMP9_FASLG_UVRAG DRAM_FAS_LC3_FASLG_LAMP2_UVRAG
ATG3_DIABLO_FAS_LC3_FASLG ATG3_FAS_FRAP1_LC3_MMP9_FASLG
DIABLO_FAS_LC3_BHLHE41_FASLG DRAM_FAS_LC3_BECN1_FASLG_SESN3
FAS_LC3_ID2_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_BECN1_FASLG
DIABLO_FAS_LC3_FASLG_LAMP2 ATG3_DRAM_FAS_LC3_MMP9_FASLG
DRAM_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_CDH1_FASLG
DRAM_FAS_LAMP1_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN2_UVRAG
ATG3_FAS_FRAP1_LC3_FASLG BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG
FAS_LC3_FASLG_STAT3_UVRAG ATG5_DRAM_FAS_LC3_FASLG_SESN3
AKT1_BNIP3_FAS_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN3_STAT3
FAS_LC3_FASLG_SESN3_UVRAG BNIP3_FAS_LC3_FASLG_SESN2_STAT3
ATG3_DRAM_FAS_LC3_FASLG BNIP3_DIABLO_FAS_LC3_MMP9_FASLG
AKT1_DRAM_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_SESN2
FAS_LC3_FASLG_SESN2_UVRAG ATG5_FAS_LC3_MMP9_FASLG_UVRAG
FAS_LC3_BHLHE41_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_BHLHE41_FASLG
DRAM_FAS_LC3_FASLG_NAMPT DIABLO_DRAM_FAS_LC3_FASLG_STAT3
FAS_LC3_FASLG_LAMP2_UVRAG ATG3_DIABLO_FAS_LC3_FASLG_SESN3
ATG7_BNIP3_FAS_LC3_FASLG DRAM_FAS_LC3_TCF3_FASLG_UVRAG
AKT1_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1
E2F1_FAS_LC3_ID2_FASLG ATG5_DRAM_FAS_LC3_FASLG_STAT3
DRAM_FAS_LC3_CDH1_FASLG ATG7_DRAM_FAS_LC3_MMP9_FASLG
PTEN_CDH1_ID2_MMP9_TCF3 LC3_CDH1_ID2_MMP9_TCF3_FASLG

[0111]七种的组合八种的组合
ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3
ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3
ATG3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3
ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN3 ATG3_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1

[0112]BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1 ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2
ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2MMP9_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_FASLG_SESN3_SIRT1 ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3
ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN3
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3 ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SIRT1 ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAG
BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3
ATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3_SIRT1
ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN3 ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2
ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1
BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG
ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_SESN2
BNIP3_DRAM_FAS_LC3_FASLG_SESN3_STAT3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_SESN2
ATG3_FAS_LC3_ID2_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_STAT3
ATG3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN3
ATG5_DRAM_FAS_LC3_MMP9_FASLG_UVRAG ATG3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2
ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2 ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3
ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3
BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAG
ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2 ATG3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3
ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN3 ATG3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3
ATG3_FAS_LC3_FASLG_SESN2_SESN3_SIRT1 AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2
ATG3_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1
BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2 BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2
ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3
BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SIRT1
BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN3 ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2_SESN3
ATG3_FAS_LC3_BECN1_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2
ATG7_BNIP3_DRAM_FAS_LC3_MMP9_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_STAT3
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_STAT3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG
BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_STAT3
ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN3
BNIP3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 BNIP3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2
ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN3 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG
BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN3 ATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2
ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_BECN1_FASLG
BNIP3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG BNIP3_CSE1L_DRAM_FAS_LC3_MMP9_FASLG_SESN3
ATG3_FAS_LC3_FASLG_LAMP2_SESN2_SESN3 ATG3_DRAM_FAS_LC3_ULK1_MMP9_FASLG_SESN3
BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3
BNIP3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1
ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN3 ATG3_FAS_LC3_ULK1_MMP9_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAG
BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3_SIRT1
FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG ATG3_FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG

[0113] 优选的是，所述组合物或试剂盒用于预测C组的存活预后，并且所述基因是选自下表14所示的基因或基因的组中的一种或多种。

[0114] [表14]

[0115]一种两种的组合三种的组合四种的组合
CSE1L ID2_CIAP2 ID2_CIAP2_SESN2 AIFM1_ID2_CIAP2_SESN2
CIAP2 CASP3_CIAP2 ID2_CASP3_CIAP2 PTEN_ID2_CIAP2_SESN2

[0116]TCF3 ID2_TCF3 ULK1_ID2_HMGB2 DIABLO_ID2_CASP3_CIAP2
CDH2 DIABLO_CDH2 ULK1_ID2_HMGB1 DRAM_FRAP1_CIAP2_TP63
FASLG CSE1L_CDH2 DIABLO_ID2_CASP3 BAX_ID2_CIAP2_SESN2
BECN1 CSE1L_TCF3 ULK1_ID2_AGER ID2_CIAP2_SESN2_VEGF
CASP3 CSE1L_CASP3 ID2_CIAP2_RPS19BP1 DRAM_ID2_CIAP2_SESN2
CDH1 CSE1L_RPS19BP1 CASP8_ULK1_ID2 ID2_CIAP2_RPS19BP1_SESN2
CDH2_CIAP2 ID2_TCF3_CIAP2 CBS_ID2_CIAP2_SESN2
ULK1_ID2 FRAP1_ID2_CIAP2 ATG3_ID2_CIAP2_SESN2
CSE1L_ID2 AIFM1_CDH1_CIAP2 NNMT_ID2_CIAP2_SESN2
CDH1_CIAP2 PTEN_CDH1_CIAP2 DIABLO_ID2_CIAP2_SESN2
CSE1L_FASLG ULK1_ID2_CIAP2 PRKAA1_ID2_CIAP2_SESN2
NNMT_CIAP2 DIABLO_ID2_CDH2 FRAP1_ID2_CIAP2_SESN2
CSE1L_MMP9 CDH1_CIAP2_VEGF DIABLO_DRAM_ID2_CASP3
CSE1L_CDH1 CDH1_CCNG2_CIAP2 XIAP_ID2_CIAP2_SESN2
CIAP2_RPS19BP1 BAX_CDH1_CIAP2 ID2_CIAP2_RAGE_SESN2
ID2_CDH2 ATG3_ID2_TCF3 DRAM_CIAP2_SESN2_TP63
CDH2_RPS19BP1 ULK1_ID2_MMP2 BNIP3_ID2_CIAP2_SESN2
CSE1L_STAT3 CBS_ULK1_ID2 BCL2L1_ID2_CIAP2_SESN2
DIABLO_CASP3 DIABLO_ID2_CIAP2 AIFM1_DIABLO_CDH1_CIAP2
CDH1_TCF3 LC3_ID2_CIAP2 ID2_CCNG2_CIAP2_SESN2
CSE1L_SIRT1 PTEN_ULK1_ID2 LC3_ID2_CIAP2_SESN2
CIAP2_SESN2 BAX_ULK1_ID2 ID2_CASP3_CIAP2_RPS19BP1
AIFM1_CIAP2 DIABLO_PTEN_CDH1 AIFM1_CDH1_CIAP2_SESN2
DIABLO_KIAA1967 CDH1_CASP3_CIAP2 ATG3_ID2_TCF3_RPS19BP1
CSE1L_KIAA1967 ULK1_ID2_CDH2 DIABLO_FRAP1_ID2_CDH2
AKT1_CSE1L CDH1_CIAP2_RAGE E2F1_ID2_CIAP2_SESN2
CSE1L_SESN2 ID2_CDH2_CIAP2 ID2_CASP3_CIAP2_SESN2
FRAP1_CDH2 NNMT_ID2_CIAP2 DRAM_ID2_CIAP2_RPS19BP1
FRAP1_CIAP2 XIAP_CIAP2_SESN2 ID2_CIAP2_HMGB1_SESN2
TCF3_FASLG CSE1L_ID2_CASP3 PTEN_ID2_CASP3_CIAP2
FASLG_SESN2 CSE1L_FRAP1_CDH2 ATG3_ID2_MMP9_TCF3
CSE1L_DIABLO BCL2_ID2_SESN2 LAMP1_ID2_CIAP2_SESN2
CSE1L_SATB1 AIFM1_ULK1_ID2 AIFM1_ID2_CASP3_CIAP2
MMP9_TCF3 ULK1_ID2_RAGE ATG5_ID2_CIAP2_SESN2
ATG12_CSE1L DIABLO_CDH1_CCNG2 DIABLO_PTEN_CDH1_CIAP2
ATG7_CSE1L BAX_DIABLO_CDH1 LAMP1_ID2_CASP3_CIAP2
CSE1L_BECN1 CSE1L_ID2_CDH2 ID2_CIAP2_HMGB2_SESN2
XIAP_CIAP2 AIFM1_CIAP2_SESN2 BCL2L1_CSE1L_ID2_SESN2
CSE1L_FAS NNMT_CDH1_CIAP2 TKT_ID2_CIAP2_SESN2
TCF3_RPS19BP1 CBS_ID2_CIAP2 DIABLO_XIAP_ID2_SESN2
XIAP_SESN2 DIABLO_CDH1_VEGF FRAP1_LC3_ID2_CIAP2
CIAP2_KIAA1967 ID2_MMP9_TCF3 ATG7_ID2_CIAP2_SESN2
TKT_CIAP2 AIFM1_DIABLO_CDH1 ID2_AGER_CIAP2_SESN2
PRKAA1_CIAP2 PRKAA1_CIAP2_SESN2 CSE1L_ID2_CASP3_CIAP2
CDH2_FASLG CDH1_ID2_CIAP2 DRAM_CASP3_CIAP2_TP63
CSE1L_FRAP1 CSE1L_CASP3_CIAP2 PTEN_CDH1_ID2_CIAP2
CSE1L_CIAP2 ULK1_ID2_VEGF CDH1_ID2_CIAP2_RPS19BP1
CSE1L_ULK1 ID2_CIAP2_HMGB1 ATG3_ULK1_ID2_HMGB1
PTEN_CIAP2 BCL2L1_CDH1_CIAP2 FRAP1_ID2_CIAP2_RPS19BP1
BCL2L1_CIAP2 ID2_CIAP2_MMP2 DIABLO_PTEN_ID2_CASP3
CIAP2_VEGF CSE1L_ID2_CIAP2 ID2_CIAP2_SESN2_TP63
ATG3_TCF3 BCL2L1_CSE1L_CDH1 ID2_TCF3_CIAP2_SESN2
AKT1_TCF3 CSE1L_CDH1_CASP3 DIABLO_CDH1_CIAP2_VEGF
CSE1L_LC3 CSE1L_XIAP_SESN2 ATG3_ULK1_ID2_AGER
TKT_CDH2 PRKAA1_CDH1_CIAP2 ID2_CIAP2_MMP2_SESN2
CDH1_ID2_MMP9_TCF3

[0117]五种的组合六种的组合
DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_TKT_CIAP2_TP63
AIFM1_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_TKT_CIAP2_SESN2_TP63
DRAM_FRAP1_CDH1_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_CIAP2_TP63

[0118]ATG12_DRAM_FRAP1_CIAP2_TP63 AIFM1_DRAM_ID2_CIAP2_SESN2_TP63
DRAM_FRAP1_XIAP_CIAP2_TP63 DRAM_TKT_ID2_CIAP2_SESN2_TP63
DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG3_DRAM_CIAP2_SESN2_TP63
AIFM1_CDH1_ID2_CIAP2_SESN2 DRAM_FRAP1_TKT_CDH1_CIAP2_TP63
AIFM1_DRAM_FRAP1_CIAP2_TP63 ATG3_DRAM_ID2_CIAP2_SESN2_TP63
DRAM_FRAP1_TKT_CIAP2_TP63 DRAM_PTEN_ID2_CIAP2_SESN2_TP63
PTEN_CDH1_ID2_CIAP2_SESN2 DRAM_FRAP1_TKT_XIAP_CIAP2_TP63
BAX_CDH1_ID2_CIAP2_SESN2 DRAM_E2F1_FRAP1_CDH1_CIAP2_TP63
DRAM_FRAP1_ID2_CIAP2_TP63 ATG3_DRAM_FRAP1_CDH1_CIAP2_TP63
DRAM_TKT_CASP3_CIAP2_TP63 ATG7_DRAM_ID2_CIAP2_SESN2_TP63
CDH1_ID2_CCNG2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_CDH1_CIAP2_TP63
AIFM1_PTEN_ID2_CIAP2_SESN2 ATG5_DRAM_ID2_CIAP2_SESN2_TP63
DIABLO_FRAP1_CDH1_ID2_CIAP2 AIFM1_DIABLO_CDH1_ID2_CIAP2_SESN2
AIFM1_CBS_ID2_CIAP2_SESN2 AIFM1_BNIP3_DRAM_CIAP2_SESN2_TP63
AIFM1_LAMP1_ID2_CIAP2_SESN2 BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63
DRAM_ID2_CASP3_CIAP2_TP63 DRAM_NNMT_ID2_CIAP2_SESN2_TP63
DIABLO_PTEN_CDH1_ID2_CIAP2 CASP8_DRAM_ID2_CIAP2_SESN2_TP63
CDH1_ID2_CIAP2_SESN2_VEGF DRAM_ID2_BHLHE41_CIAP2_SESN2_TP63
DIABLO_CDH1_ID2_CASP3_CIAP2 DRAM_FRAP1_CDH1_CIAP2_RPS19BP1_TP63
AIFM1_ATG3_ID2_CIAP2_SESN2 DRAM_LAMP1_ID2_CIAP2_SESN2_TP63
AIFM1_BNIP3_ID2_CIAP2_SESN2 DRAM_FRAP1_CDH1_ID2_CIAP2_TP63
AIFM1_DIABLO_CDH1_ID2_CIAP2 BNIP3_DRAM_ID2_CIAP2_SESN2_TP63
ATG3_DRAM_ID2_CIAP2_SESN2 DRAM_ID2_MMP9_CIAP2_SESN2_TP63
AIFM1_BAX_ID2_CIAP2_SESN2 AKT1_DRAM_ID2_CIAP2_SESN2_TP63
DRAM_E2F1_CASP3_CIAP2_TP63 DRAM_ID2_CIAP2_RAGE_SESN2_TP63
AIFM1_ID2_CIAP2_HMGB2_SESN2 ATG12_DRAM_FRAP1_XIAP_CIAP2_TP63
AIFM1_ID2_MMP9_CIAP2_SESN2 DRAM_PRKAA1_ID2_CIAP2_SESN2_TP63
DIABLO_CDH1_ID2_CIAP2_VEGF DRAM_XIAP_ID2_CIAP2_SESN2_TP63
DIABLO_DRAM_XIAP_ID2_SESN2 AIFM1_DRAM_PTEN_CIAP2_SESN2_TP63
AIFM1_ATG5_ID2_CIAP2_SESN2 ATG3_DRAM_FRAP1_CASP3_CIAP2_TP63
AIFM1_ID2_CIAP2_HMGB1_SESN2 CASP8_DRAM_FRAP1_CDH1_CIAP2_TP63
BAX_DIABLO_CDH1_ID2_CIAP2 AIFM1_ATG5_DRAM_CIAP2_SESN2_TP63
DRAM_FRAP1_NNMT_CIAP2_TP63 AIFM1_CASP8_DRAM_CIAP2_SESN2_TP63
FRAP1_CDH1_ID2_CIAP2_RPS19BP1 BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63
DRAM_XIAP_CIAP2_SESN2_TP63 CBS_DRAM_ID2_CIAP2_SESN2_TP63
AIFM1_DIABLO_ID2_CIAP2_SESN2 DRAM_FRAP1_NNMT_TKT_CIAP2_TP63
AIFM1_DRAM_ID2_CIAP2_SESN2 AIFM1_AKT1_DRAM_CIAP2_SESN2_TP63
AIFM1_ID2_CIAP2_SESN2_VEGF DRAM_FRAP1_PTEN_CDH1_CIAP2_TP63
AIFM1_TKT_ID2_CIAP2_SESN2 DIABLO_PTEN_CDH1_ID2_CIAP2_SESN2
ATG3_ID2_MMP9_TCF3_RPS19BP1 DRAM_ID2_CIAP2_SESN2_TP63_VEGF
ATG5_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_XIAP_CIAP2_SESN2_TP63
CBS_FRAP1_ID2_CIAP2_SESN2 BNIP3_DRAM_FRAP1_CDH1_CIAP2_TP63
AIFM1_DIABLO_ID2_CASP3_CIAP2 AIFM1_ATG7_DRAM_CIAP2_SESN2_TP63
AIFM1_NNMT_ID2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_NNMT_CIAP2_TP63
ATG3_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_MMP9_CIAP2_SESN2_TP63
ATG3_FRAP1_ID2_CIAP2_SESN2 AIFM1_DRAM_PRKAA1_CIAP2_SESN2_TP63
BAX_DIABLO_DRAM_ID2_CASP3 AIFM1_DRAM_CIAP2_RAGE_SESN2_TP63
LAMP1_PTEN_ID2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_XIAP_CIAP2_TP63
CDH1_ID2_CIAP2_RAGE_SESN2 AIFM1_DRAM_NNMT_CIAP2_SESN2_TP63
CBS_DIABLO_ID2_CIAP2_SESN2 DRAM_FRAP1_CDH1_CIAP2_TP63_VEGF
DIABLO_CDH1_ID2_CCNG2_CIAP2 AIFM1_DRAM_LAMP1_CIAP2_SESN2_TP63
DIABLO_LAMP1_ID2_CASP3_CIAP2 DIABLO_DRAM_FRAP1_XIAP_CASP3_HMGB2
AIFM1_DRAM_CASP3_CIAP2_TP63 DRAM_TKT_XIAP_CIAP2_SESN2_TP63
BCL2L1_DRAM_FRAP1_CIAP2_TP63 AIFM1_BCL2L1_DRAM_CIAP2_SESN2_TP63
CDH1_ID2_MMP9_TCF3_CIAP2 BAX_CDH1_ID2_MMP9_TCF3_CIAP2

[0119]七种的组合八种的组合
AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63
ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63
ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63
ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF

[0120]ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_PTEN_TKT_XIAP_CIAP2_TP63
ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF AIFM1_ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63
ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_SATB1_TP63
ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 AIFM1_AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63
ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63
ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63 ATG12_BCL2L1_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63
ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63 AIFM1_ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63
ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PTEN_MMP9_CIAP2_TP63
AIFM1_BCL2L1_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_E2F1_FRAP1_TKT_MMP9_CIAP2_TP63
AIFM1_ATG12_DRAM_FRAP1_PTEN_CIAP2_TP63 ATG12_BCL2L1_CBS_DRAM_FRAP1_TKT_CIAP2_TP63
AIFM1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF
AIFM1_DRAM_PTEN_ID2_CIAP2_SESN2_TP63 ATG12_DIABLO_DRAM_FRAP1_TKT_CDH1_CIAP2_TP63
AIFM1_DRAM_TKT_MMP9_CIAP2_SESN2_TP63 AIFM1_ATG3_DRAM_ID2_MMP9_CIAP2_SESN2_TP63
ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63 ATG12_CBS_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63
AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_LAMP1_TKT_XIAP_CIAP2_TP63
ATG12_DRAM_E2F1_FRAP1_TKT_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63
ATG12_DRAM_FRAP1_TKT_BHLHE41_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_HMGB1_TP63
AIFM1_ATG12_DRAM_FRAP1_MMP9_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63
AIFM1_ATG3_DRAM_ID2_CIAP2_SESN2_TP63 AIFM1_DRAM_PTEN_ID2_MMP9_CIAP2_SESN2_TP63
AIFM1_ATG3_DRAM_MMP9_CIAP2_SESN2_TP63 ATG12_ATG7_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63
ATG12_DRAM_FRAP1_TKT_CIAP2_HMGB1_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63_VEGF
AIFM1_ATG12_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63
AIFM1_BNIP3_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63
AIFM1_DRAM_ID2_MMP9_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63
AIFM1_DRAM_LAMP1_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63_VEGF
DRAM_FRAP1_TKT_CASP3_CIAP2_HMGB2_TP63 ATG12_DRAM_FRAP1_LAMP1_PTEN_TKT_CIAP2_TP63
AIFM1_AKT1_ATG12_DRAM_FRAP1_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63
AIFM1_DRAM_PRKAA1_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63
AIFM1_DRAM_TKT_CIAP2_RAGE_SESN2_TP63 AIFM1_ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_TP63
AIFM1_DRAM_TKT_ID2_CIAP2_SESN2_TP63 ATG12_BCL2L1_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63
ATG12_DRAM_FRAP1_TKT_CIAP2_SATB1_TP63 ATG12_CBS_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63
AIFM1_AKT1_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_LAMP1_PRKAA1_TKT_CIAP2_TP63
AIFM1_ATG12_DRAM_FRAP1_CIAP2_TP63_VEGF ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_RAGE_TP63
AIFM1_ATG3_DRAM_NNMT_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63
AIFM1_BAX_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_BCL2L1_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63
AIFM1_DRAM_NNMT_ID2_CIAP2_SESN2_TP63 ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF
DRAM_FRAP1_NNMT_TKT_XIAP_CIAP2_TP63 AIFM1_ATG3_DRAM_NNMT_ID2_CIAP2_SESN2_TP63
BCL2L1_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_DRAM_NNMT_PTEN_ID2_CIAP2_SESN2_TP63
AIFM1_ATG12_ATG3_DRAM_FRAP1_CIAP2_TP63 ATG12_CBS_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63
AIFM1_ATG7_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_PTEN_TKT_MMP9_CIAP2_TP63
AIFM1_DRAM_TKT_CIAP2_SESN2_TP63_VEGF AIFM1_ATG12_ATG3_DRAM_FRAP1_MMP9_CIAP2_TP63
ATG12_ATG3_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_CASP8_DRAM_TKT_CIAP2_SESN2_TP63
AIFM1_AKT1_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_ATG7_CBS_DRAM_FRAP1_TKT_CIAP2_TP63
AIFM1_ATG12_ATG7_DRAM_FRAP1_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63
AIFM1_ATG3_BCL2L1_DRAM_CIAP2_SESN2_TP63 AIFM1_ATG12_DRAM_PTEN_TKT_CIAP2_SESN2_TP63
AIFM1_ATG7_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_BCL2L1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63
AIFM1_BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_E2F1_FRAP1_NNMT_TKT_CIAP2_TP63
AIFM1_CBS_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF
AIFM1_DRAM_PTEN_TKT_CIAP2_SESN2_TP63 ATG12_BNIP3_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63
AIFM1_DRAM_TKT_BHLHE41_CIAP2_SESN2_TP63 ATG12_CBS_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63
ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_TP63 ATG12_DIABLO_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63
BCL2L1_DRAM_TKT_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_PRKAA1_TKT_XIAP_CIAP2_TP63
BAX_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_RAGE_TP63
CBS_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3 ATG3_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3_AGER

[0121] 优选的是，所述组合物或试剂盒用于预测C组的无病存活预后，并且所述基因是选自下表15所示的基因或基因的组中的一种或多种。

[0122] [表15]

[0123]一种两种的组合三种的组合四种的组合
FASLG FAS_FASLG FAS_LC3_FASLG DIABLO_FAS_LC3_FASLG
CIAP2 LC3_FASLG DIABLO_FAS_FASLG FAS_LC3_FASLG_UVRAG
FAS E2F1_FASLG E2F1_LC3_FASLG E2F1_FAS_LC3_FASLG
CSE1L CIAP2_FASLG FAS_FASLG_RPS19BP1 BNIP3_FAS_LC3_FASLG
TCF3 DIABLO_FASLG E2F1_FAS_FASLG DRAM_FAS_LC3_FASLG
FASLG_RPS19BP1 FAS_FASLG_UVRAG ATG7_FAS_LC3_FASLG
FASLG_SESN2 DIABLO_LC3_FASLG FAS_LAMP1_LC3_FASLG
CASP3_FASLG ATG7_FAS_FASLG FAS_FRAP1_LC3_FASLG
FASLG_UVRAG FAS_FASLG_SESN2 ATG3_FAS_LC3_FASLG
FRAP1_FASLG LC3_FASLG_SESN2 FAS_LC3_FASLG_RPS19BP1
PTEN_FASLG FAS_LAMP1_FASLG FAS_LC3_FASLG_SESN3
FASLG_HMGB1 ATG3_FAS_FASLG FAS_LC3_FASLG_SESN2
ATG3_FAS CIAP2_FASLG_SESN3 ATG5_FAS_LC3_FASLG
CASP3_CIAP2 FAS_FRAP1_FASLG FAS_LC3_FASLG_STAT3
TCF3_FASLG FRAP1_LC3_FASLG FAS_LC3_FASLG_SIRT1
ATG7_FASLG BNIP3_LC3_FASLG AKT1_FAS_LC3_FASLG
PTEN_CIAP2 FAS_FASLG_SESN3 FAS_LC3_ID2_FASLG
CDH2_FASLG BNIP3_FAS_FASLG FAS_LC3_FASLG_NAMPT
FASLG_SESN3 DIABLO_FASLG_SESN2 FAS_LC3_BECN1_FASLG
DIABLO_FAS CIAP2_FASLG_UVRAG FAS_LC3_MMP9_FASLG
FAS_LC3 LC3_FASLG_UVRAG DIABLO_FAS_FASLG_UVRAG
ULK1_FASLG LC3_CIAP2_FASLG ATG12_FAS_LC3_FASLG
CSE1L_FASLG DRAM_FAS_FASLG FAS_FASLG_RPS19BP1_UVRAG
CBS_FASLG LC3_FASLG_SESN3 DIABLO_FAS_FASLG_SESN2
FASLG_HMGB2 FAS_FASLG_STAT3 FAS_LC3_FASLG_LAMP2
FAS_UVRAG ATG7_LC3_FASLG FAS_LC3_CDH1_FASLG
LAMP1_FASLG ATG5_FAS_FASLG DIABLO_FAS_FASLG_SESN3
BNIP3_FASLG E2F1_FASLG_SESN2 FAS_LC3_TCF3_FASLG
MMP9_FASLG LC3_ID2_FASLG E2F1_LC3_ID2_FASLG
TKT_FASLG DRAM_LC3_FASLG FAS_LC3_BHLHE41_FASLG
FASLG_STAT3 FAS_TCF3_FASLG DIABLO_FAS_LAMP1_FASLG
AKT1_FASLG AKT1_FAS_FASLG DIABLO_DRAM_FAS_FASLG
FASLG_MMP2 E2F1_ULK1_FASLG FAS_FASLG_SESN2_UVRAG
DRAM_FASLG E2F1_TCF3_FASLG FAS_FASLG_RPS19BP1_SESN3
FASLG_SIRT1 LC3_FASLG_RPS19BP1 DIABLO_FAS_FRAP1_FASLG
ATG12_FASLG LC3_MMP9_FASLG DIABLO_FAS_FASLG_STAT3
CIAP2_RAGE FAS_FASLG_SIRT1 ATG7_DIABLO_FAS_FASLG
FAS_LAMP1 FAS_ULK1_FASLG CSE1L_FAS_LC3_FASLG
ATG5_FASLG FAS_FASLG_NAMPT E2F1_LC3_MMP9_FASLG
ATG3_FASLG LC3_FASLG_SIRT1 DRAM_FAS_FASLG_RPS19BP1
E2F1_FAS CASP3_CIAP2_FASLG DIABLO_FAS_FASLG_RPS19BP1
BECN1_FASLG ATG12_FAS_FASLG FAS_LC3_ULK1_FASLG
E2F1_CIAP2 FAS_BECN1_FASLG DIABLO_FAS_FASLG_SIRT1
CASP8_FASLG ATG5_LC3_FASLG DIABLO_FAS_ID2_FASLG
XIAP_CIAP2 LC3_BECN1_FASLG AKT1_DIABLO_FAS_FASLG
CDH1_FASLG LC3_FASLG_STAT3 DIABLO_FAS_FASLG_NAMPT
FASLG_NAMPT E2F1_FASLG_SESN3 ATG3_FAS_FASLG_SESN2
BNIP3_FAS AKT1_LC3_FASLG FAS_FASLG_RPS19BP1_SESN2
FASLG_LAMP2 FAS_FASLG_LAMP2 DIABLO_FAS_BECN1_FASLG
AGER_FASLG LC3_TCF3_FASLG DIABLO_FAS_CDH1_FASLG
ID2_FASLG LC3_FASLG_NAMPT ATG7_FAS_FASLG_UVRAG
AIFM1_FASLG LC3_CDH1_FASLG DIABLO_FAS_FASLG_LAMP2
FASLG_SESN1 ATG12_LC3_FASLG FAS_FRAP1_FASLG_RPS19BP1
AIFM1_CIAP2 PTEN_CDH1_CIAP2 FAS_LAMP1_FASLG_UVRAG
PRKAA1_CIAP2 LC3_FASLG_LAMP2 E2F1_FAS_LAMP1_FASLG
BCL2L1_CIAP2 DIABLO_FASLG_SESN3 ATG7_FAS_FASLG_RPS19BP1
XIAP_FASLG FAS_CDH1_FASLG E2F1_FAS_FASLG_UVRAG
CDH1_ID2_MMP9_TCF3

[0124]五种的组合六种的组合

[0125]DIABLO_FAS_LC3_ID2_FASLG BNIP3_DRAM_FAS_LC3_FASLG_SESN2
DRAM_FAS_LC3_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG
DIABLO_DRAM_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2
BNIP3_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_ID2_FASLG_UVRAG
BNIP3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_UVRAG
BNIP3_DRAM_FAS_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN2_UVRAG
BNIP3_DIABLO_FAS_LC3_FASLG DIABLO_FAS_LC3_ID2_FASLG_UVRAG
FAS_LC3_ID2_FASLG_UVRAG DIABLO_FAS_LC3_ID2_FASLG_STAT3
DIABLO_FAS_LC3_FASLG_UVRAG DIABLO_FAS_LC3_ID2_FASLG_SESN3
DIABLO_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_MMP9_FASLG_UVRAG
DIABLO_FAS_LC3_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_FASLG_SESN3
DIABLO_FAS_LC3_FASLG_SIRT1 BNIP3_FAS_LC3_ID2_FASLG_UVRAG
FAS_LC3_MMP9_FASLG_RPS19BP1 DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1
ATG5_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1
BNIP3_FAS_LC3_FASLG_SESN3 BNIP3_FAS_LC3_ID2_FASLG_SESN2
DIABLO_FAS_LC3_BECN1_FASLG BNIP3_DIABLO_FAS_LC3_ID2_FASLG
DIABLO_FAS_LC3_CDH1_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN2
ATG3_FAS_LC3_FASLG_SESN2 DIABLO_FAS_LC3_ID2_FASLG_SIRT1
DRAM_E2F1_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_UVRAG
FAS_LC3_FASLG_SESN2_UVRAG FAS_LC3_MMP9_FASLG_RPS19BP1_UVRAG
DIABLO_FAS_LC3_FASLG_LAMP2 ATG3_FAS_LC3_FASLG_SESN2_SESN3
E2F1_FAS_LC3_ID2_FASLG DRAM_FAS_LC3_FASLG_SESN2_UVRAG
DIABLO_FAS_LC3_FASLG_NAMPT DIABLO_FAS_LC3_ID2_BECN1_FASLG
DIABLO_FAS_LC3_MMP9_FASLG DRAM_FAS_LC3_FASLG_SIRT1_UVRAG
FAS_LC3_FASLG_SIRT1_UVRAG FAS_LC3_ID2_FASLG_SESN2_UVRAG
FAS_LC3_FASLG_SESN3_UVRAG DIABLO_FAS_LC3_CDH1_ID2_FASLG
FAS_LAMP1_LC3_FASLG_UVRAG FAS_LC3_ID2_MMP9_FASLG_RPS19BP1
AKT1_DIABLO_FAS_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN2_SESN3
DIABLO_FAS_FRAP1_LC3_FASLG DIABLO_FAS_LC3_ID2_FASLG_NAMPT
DIABLO_FAS_LC3_BHLHE41_FASLG DIABLO_FAS_LC3_ID2_FASLG_SESN2
FAS_LC3_FASLG_STAT3_UVRAG DIABLO_FAS_LC3_ID2_FASLG_LAMP2
DIABLO_FAS_LC3_FASLG_SESN2 BNIP3_FAS_LC3_FASLG_SESN2_SIRT1
E2F1_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN2_STAT3
BNIP3_FAS_FRAP1_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN3_UVRAG
DIABLO_FAS_LAMP1_LC3_FASLG DIABLO_DRAM_FAS_LC3_FASLG_STAT3
FAS_LC3_BECN1_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG
AKT1_FAS_LC3_FASLG_UVRAG ATG5_FAS_LC3_ID2_FASLG_UVRAG
BNIP3_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN3_UVRAG
FAS_FRAP1_LC3_FASLG_UVRAG DRAM_FAS_LC3_BECN1_FASLG_UVRAG
BNIP3_FAS_LC3_FASLG_STAT3 DIABLO_DRAM_FAS_LC3_CDH1_FASLG
FAS_LC3_CDH1_FASLG_UVRAG AKT1_DIABLO_FAS_LC3_ID2_FASLG
FAS_LC3_FASLG_LAMP2_UVRAG BNIP3_DIABLO_FAS_LC3_MMP9_FASLG
FAS_LC3_MMP9_FASLG_UVRAG DRAM_FAS_LC3_CDH1_FASLG_UVRAG
ATG7_FAS_LC3_FASLG_UVRAG DIABLO_FAS_FRAP1_LC3_ID2_FASLG
ATG7_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_STAT3
BNIP3_FAS_LC3_FASLG_SIRT1 DIABLO_DRAM_FAS_LC3_FASLG_SESN3
DRAM_FAS_LAMP1_LC3_FASLG BNIP3_DIABLO_DRAM_FAS_LC3_FASLG
ATG7_BNIP3_FAS_LC3_FASLG DIABLO_DRAM_FAS_LC3_FASLG_SIRT1
BNIP3_FAS_LAMP1_LC3_FASLG BNIP3_DRAM_FAS_FRAP1_LC3_FASLG
ATG3_FAS_LC3_MMP9_FASLG DIABLO_DRAM_FAS_LC3_BECN1_FASLG
ATG5_DIABLO_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN3
BNIP3_FAS_LC3_ID2_FASLG DIABLO_FAS_LAMP1_LC3_ID2_FASLG
ATG12_DIABLO_FAS_LC3_FASLG DRAM_FAS_LC3_FASLG_LAMP2_UVRAG
E2F1_FAS_LC3_FASLG_SESN3 ATG5_FAS_LC3_FASLG_SESN2_UVRAG
AKT1_BNIP3_FAS_LC3_FASLG FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3
FAS_LC3_FASLG_NAMPT_UVRAG FAS_LAMP1_LC3_ID2_FASLG_UVRAG
ATG12_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG
PTEN_CDH1_ID2_MMP9_TCF3 LC3_CDH1_ID2_MMP9_TCF3_FASLG

[0126]七种的组合八种的组合
ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3

[0127]BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG
BNIP3_FAS_LC3_ID2_FASLG_SESN2_UVRAG ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3
ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3
ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2
BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAG
FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_ID2_FASLG_UVRAG ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG
DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAG
DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 ATG5_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG
ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1 ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAG ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3 ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2
BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAG ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1
ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_TCF3_FASLG_UVRAG
DIABLO_DRAM_FAS_LC3_ID2_FASLG_STAT3 DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3
ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3
DIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1
BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAG
ATG5_DRAM_FAS_LC3_ID2_FASLG_UVRAG ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1 ATG3_DIABLO_FAS_LC3_ID2_MMP9_FASLG_SESN2
ATG5_FAS_LC3_ID2_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAG
ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG
DIABLO_DRAM_FAS_LC3_ID2_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2
DIABLO_DRAM_FAS_LC3_CDH1_ID2_FASLG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1
DRAM_FAS_LC3_ID2_FASLG_SIRT1_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3
DIABLO_DRAM_FAS_LC3_ID2_FASLG_SIRT1 ATG3_FAS_LC3_ID2_MMP9_TCF3_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3
FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3 ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3
BNIP3_FAS_LC3_ID2_MMP9_FASLG_UVRAG BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN2_UVRAG
DIABLO_DRAM_FAS_LC3_ID2_BECN1_FASLG ATG5_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG
DRAM_FAS_LC3_ID2_FASLG_SESN3_UVRAG BNIP3_FAS_LC3_CDH1_ID2_FASLG_SESN2_UVRAG
ATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2 BNIP3_FAS_LC3_ID2_FASLG_SESN2_SIRT1_UVRAG
BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3 ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3
BNIP3_FAS_LC3_ID2_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_CDH1_ID2_FASLG_SESN2
DIABLO_DRAM_FAS_LC3_ID2_FASLG_LAMP2 BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN3_UVRAG
BNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2 AKT1_BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2
ATG5_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_LAMP2_SESN2
DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_UVRAG ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3
DRAM_FAS_LAMP1_LC3_ID2_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2_UVRAG
DIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN2 BNIP3_FAS_LC3_ID2_FASLG_LAMP2_SESN2_UVRAG
ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2 BNIP3_FAS_LC3_ID2_BECN1_FASLG_SESN2_UVRAG
AKT1_BNIP3_DRAM_FAS_LC3_FASLG_SESN2 BNIP3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG
DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 BNIP3_DRAM_FAS_LC3_ID2_TCF3_FASLG_UVRAG
ATG3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3
ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1
BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG
DRAM_FAS_LC3_ID2_FASLG_STAT3_UVRAG ATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_CDH1_FASLG_UVRAG BNIP3_DRAM_FAS_LAMP1_LC3_ID2_FASLG_SESN2
ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 ATG3_FAS_FRAP1_LC3_ID2_MMP9_FASLG_SESN2
DRAM_FAS_LC3_ID2_BECN1_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2
E2F1_LC3_CDH1_ID2_MMP9_TCF3_FASLG FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG_UVRAG

[0128] 本发明的组合物或试剂盒中包含的核酸可以是引物或探针。

[0129] 这些核酸可以具有诸如DNA和/或RNA等基因的互补序列，或者可以是杂交的。“引物”是指具有游离3′羟基的核酸序列，其能够与模板互补结合，并且使逆转录酶或DNA
聚合酶能够引发模板的复制。引物是序列与特定基因的核酸序列互补的核苷酸，可以使用
长度为约7bp～50bp、优选为约10bp～30bp的引物。引物可以包含不改变该引物的在DNA
合成酶起始点发挥作用的基本特征的其他碱基序列。引物可以使用公知方法以化学手段合
成，核酸序列可以使用相关领域中的多种公知手段来转化。

[0130] “探针”是指与靶核酸部分互补或完全互补的核酸链，和指能够用碱基特异性方法与靶核酸结合的寡核苷酸。优选的是，探针为与靶核酸完全互补的寡核苷酸。探针不仅包
括核酸，而且还包括能够进行互补结合的任何已知的核酸衍生物(包括肽核酸)。探针与靶
核酸的结合(通常称之为“杂交”)是序列依赖性的，并且可以在多种条件下进行。通常，杂
交反应在特定的离子水平和pH水平下在比特定序列的Tm低约5℃的温度进行。“Tm”是指
下述条件：与靶标序列互补的探针已有50％结合到了该序列上。杂交反应条件的实例可以
是pH为7.0～8.3且Na+离子浓度为0.01M～1.0M。此外，为了提高靶核酸和探针之间的
特异性，该反应可以在不会使靶核酸与探针之间的结合变得不稳定的条件下进行，例如，在
温度不高且不存在高浓度的去稳定剂(例如，甲酰胺等)的条件下进行。探针的长度可以
是使得探针能够特异性地结合靶核酸的长度，其包括任何长度的多核苷酸。例如，探针的长
度可以是10～200个核苷酸、10～150个核苷酸、10～100个核苷酸、10～50个核苷酸或
整个基因的长度，但并不限于此。可以用可检测标记来标记探针。可检测标记可以在SYBR
Green I或各种探针(TaqMan探针)的5′末端标记有荧光物质FAM，并且在其3′末端标
记有淬灭剂TAMRA，但并不限于此。可检测标记包括荧光标记(例如Cy3或Cy5)、放射性物
质标记、将底物转化为显色物的酶等，但并不限于此。在本发明的试剂盒中，探针或探针组
可以固定在微阵列上。

[0131] 使样品中的靶核酸与微阵列中的探针杂交，并且可以通过测量杂交结果来测定靶核酸的存在和浓度。可以用可检测标记来标记杂交过程中的靶核酸。

[0132] “抗体”是指能够特异性地结合抗原表位的蛋白，该概念包括多克隆抗体、单克隆抗体和重组抗体。抗体可以使用本领域中熟知的技术来容易地制造。具体而言，多克隆抗
体可以使用本领域中熟知的下述方法来制造：将由本发明的肝癌预后标志物编码的蛋白抗
原注射到动物体内并收集该动物的血液，从而获得包含抗体的血清。这些多克隆抗体可以
从多种动物物种宿主制备，例如山羊、兔、绵羊、马、猪、牛和犬等。

[0133] 单克隆抗体可以使用本领域中熟知的杂交瘤法[Kohler和Milstein(1976)European Journal of Immunology6：511-519]或噬菌体抗体文库技术[Clackson等，
Nature，352：624-628，1991；Marks等，J.Mol.Biol.，222：58，1-597，1991]等来制备。

[0134] 通常，杂交瘤法使用从已经注射了本发明第一方面的肝癌预后标志物所编码的蛋白抗原的免疫学适用宿主动物(例如小鼠)获得的细胞，并使用癌细胞系或骨髓瘤细胞系
作为另一群体。使用本领域熟知的方法(例如聚乙二醇)使从这两个群体获得的组织融
合，随后使用标准组织培养法使产生抗体的细胞进行增殖。按照有限稀释技术通过亚克隆
来获得同源细胞群，随后按照已知的技术在体内或体外大量培养能够产生所需抗体的杂交
瘤。噬菌体抗体文库方法是通过下述方式产生单克隆抗体的方法：获得所需抗体的基因，在
噬菌体表面将该基因表达为融合蛋白形式，由此在体外产生抗体文库，并将所需的单克隆
抗体从该文库中分离出。用上述方法制得的单克隆抗体可以使用已知的方法来分离，例如
凝胶电泳、透析、盐析、离子交换色谱和亲和色谱等。

[0135] 除了由两条全长轻链和两条全长重链组成的完整形状外，抗体还包括抗体分子的功能片段。抗体分子的功能片段是指具有抗原结合功能的片段，包括Fab、F(ab′)、
F(ab′)2和Fv等。

[0136] 对肝癌预后的预测可以是在进行癌症肝脏切除术之前或之后的预后预测。

[0137] 除了核酸或抗体外，所述试剂盒还可以包含适用于分析基因的表达水平或表达模式的方法或适用于分析蛋白的存在水平或存在模式的方法的一种或多种其他成分、溶液或
器件。例如，对于用于检测基因的表达水平或表达模式的诊断试剂盒，该诊断试剂盒可以包
含进行RT-PCR所要求的必需成分，而且，根据具体实施方式，除了对标志基因有特异性的
各引物之外，该RT-PCR试剂盒可以包含例如试管或其他适当的容器、反应缓冲溶液、脱氧
核苷酸(dNTP)、酶(例如Taq聚合酶与逆转录酶)、DNA酶、RNA酶抑制剂、DEPC-水(DEPC
水)、无菌水、作为定量对照组使用的基因特异性引物对。同时，对于用于检测蛋白的存在
水平或存在模式的试剂盒，该诊断试剂盒可以包含例如进行ELISA所要求的必需成分。该
ELISA试剂盒可以包含能够检测到所结合的抗体(例如，带标记的二抗)、生色团、酶(例
如，连接在抗体上的酶)及其底物以及对定量对照组的蛋白有特异性的抗体的成分。此外，
根据具体实施方式，该试剂盒还可以包含DNA微阵列或蛋白微阵列。

[0138] 另外，本发明提供一种用于预测肝癌预后的组合物或试剂盒，所述组合物或试剂盒包含：对选自表2所示的组的一种或至少两种基因中的每一种分别具有特异性的核酸
(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明
中有所描述)，或对所述基因编码的蛋白有特异性的抗体。

[0139] 在该组合物或试剂盒中，基因的组还可包含表3所示的基因(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)。

[0140] 除非存在矛盾，针对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒而提及的内容也等同地适用于上述组合物和试剂盒。

[0141] 此外，本发明提供一种根据分期来预测肝癌预后的方法，所述方法包括：(A)检测获自肝癌患者的样品中的选自由表1所示的基因组成的组的一种或至少两种基因(已在对
本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所
描述)的表达水平或表达模式中的一项或多项；和(B)将步骤(A)的结果与对照组的测量
结果进行比较，从而预测肝癌预后，其中，所述肝癌患者属于选自下述各组中的一个或多个
组：A1组{门静脉侵袭阴性患者组，患者处于BCLC(巴塞罗那临床肝癌)分期系统的0期
或A期，具有1个尺寸为5cm以下的肿瘤或3个以下的尺寸为3cm以下的肿瘤}，A2组{门
静脉侵袭阴性患者组，患者具有尺寸大于5cm的肿瘤}，B组{门静脉侵袭阴性患者组，患者
处于BCLC分期系统中期，具有多个尺寸大于3cm的肿瘤或数量大于3的多个肿瘤}，或C组
{门静脉侵袭阳性患者组，不论肿瘤尺寸和数量如何}。

[0142] 优选的是，上述由基因组成的组可以是由表2所示的基因(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)组成的
组，而且，上述由基因组成的组还可以包含表3所示的基因(已在对本发明的用于根据肝癌
分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)。

[0143] 采集自肝癌患者的样品是指从能够检测到肝癌预后标志物的表达水平或表达模式的人体中或从能够检测到肝癌预后标志物所编码的蛋白的存在水平或存在模式的人体
中分离出的细胞和组织等。其实例可以是尿、血液、血浆和血清等，但并不特别限于此。所
述组织可以包埋于石蜡块中。

[0144] 所述基因的表达水平或表达模式可以用一般的生物化学分析方法来检测，这些方法用来确定由对应基因转录产生的mRNA的水平或模式。此类用于确定mRNA的水平或模式
的分析方法有RT-PCR、竞争性RT-PCR、实时RT-PCR、RNA酶保护测定、RNA印迹和DNA微阵
列等。此外，可以使用相关领域中通常使用的任何方法。

[0145] 通过上述分析方法，肝癌患者的生物样品中的mRNA的水平或模式可以与标准水平进行比较，并可以从中检测出在肝癌预后标志物的表达水平和/或表达模式方面的差
异。这使得能够对肝癌患者的预后进行预估。

[0146] 用于通过RT-PCR来测量mRNA的水平或模式的试剂盒包含对本发明的肝癌预后标志物的mRNA有特异性的引物。根据具体实施方式，RT-PCR试剂盒可以包含试管或其他适
当的容器、反应缓冲溶液、脱氧核苷酸(dNTP)、酶(例如Taq聚合酶和逆转录酶)、DNA酶、
RNA酶抑制剂、DEPC-水和无菌水等。在适合的缓冲溶液和温度下，引物能够在聚合用试剂
(即，DNA聚合酶或逆转录酶)和四种不同的三磷酸核苷的存在下引发DNA的合成。

[0147] 使用抗体来测量蛋白的表达水平或表达模式的方法有蛋白质印迹、ELISA(酶联免疫吸附测定)、放射免疫测定、放射免疫扩散、Ouchterlony免疫扩散、火箭免疫电泳、组织
免疫染色、免疫沉淀测定、补体结合测定、FACS和蛋白芯片等。此外，可以使用相关领域中
通常使用的任何方法。

[0148] 通过上述分析方法，可以将受试肝癌患者的样品中的抗原-抗体复合物的形成水平和形成模式与标准水平进行比较，并可以从中确定出本发明的肝癌预后标志物所编码的
蛋白的存在水平或存在模式，并最终能够预估出肝癌患者的预后。此处，“抗原-抗体复合
物”是指肝癌预后标志物所编码的蛋白与其特异性抗体的复合物。抗原-抗体复合物的形
成水平或形成模式通常可以通过检测与二抗联结的检测标记的信号的大小和模式来测量。
此类检测标记的实例可以是酶、荧光物质、配体、发光物质、纳米颗粒、氧化还原分子和放射
性同位素等，但并不限于此。当使用酶作为检测标记时，可以使用的酶有β-葡糖醛酸糖苷
酶、β-D-葡萄糖苷酶、β-D-半乳糖苷酶、尿素酶、过氧化物酶或碱性磷酸酶、乙酰胆碱酯
酶、葡萄糖氧化酶、己糖激酶和GDP酶、RNA酶、葡萄糖氧化酶、荧光素酶、磷酸果糖激酶、磷
酸烯醇丙酮酸羧化酶、天冬氨酸氨基转移酶、磷酸烯醇丙酮酸脱羧酶和β-内酰胺酶等，但
所述酶并不限于此。当使用荧光物质作为检测标记时，可以使用的荧光物质有荧光素、异硫
氰酸酯、罗丹明、藻红蛋白、藻蓝蛋白、别藻蓝蛋白、邻苯二醛和荧光胺等，但所述荧光物质
并不限于此。当使用配体作为检测标记时，可以使用的配体有生物素衍生物等，但所述配体
并不限于此。当使用发光物质作为检测标记时，可以使用的发光物质有吖啶酯、荧光素和荧
光素酶等，但所述发光物质并不限于此。当使用纳米颗粒作为检测标记时，可以使用的纳米
颗粒有胶体金和彩色乳胶等，但所述纳米颗粒并不限于此。当使用氧化还原分子作为检测
标记时，可以使用的氧化还原分子有二茂铁、钌络合物、紫罗碱、醌、Ti离子、Cs离子、二酰
2+ 2+ 4-
亚胺、1，4-苯醌、氢醌、K4W(CN)8、[Os(bpy)3] 、[Ru(bpy)3] 和[Mo(CN)8] 等，但所述氧化
还原分子并不限于此。当使用放射性同位素作为检测标记时，可以使用的放射性同位素有
3H、14C、32P、35S、36Cl、51Cr、57Co、58Co、59Fe、90Y、125I、131I或186Re等，但所述放射性
同位素并不限于此。

[0149] “测量结果”是指步骤(A)中的从肝癌组织等收集的基因的表达水平或表达模式中的至少一项，“对照组的结果”可以指在通过对从肝癌预后已知的肝癌患者组(A1组、A2组、
B组、C组)获得的测量值进行连续变量回归分析而获得的结果中具有最低p值的基因表达
水平，或从表达水平获得的风险评分(参见N Engl J.Med2007；356：11-20)。测量结果或
对照组的结果是用相同方法获得的表达水平或表达模式(高表达或低表达)，并且可以根
据不论患者是否患有肝癌都以恒定表达水平表达的对照基因(或基因的组)(B2M、GAPDH、
HMBS、HPRT1和SDHA等)的平均表达水平来确定。

[0150] 通过与从上述患者组获得的对照组的结果进行比较，来表征肝癌患者的测量结果，从而可以检测出其间的差异，并且可以使用任何可以检测出这种差异的物质来作为用
于特异性地检测肝癌预后标志物的表达水平和/或表达模式的物质。对照组结果与测量结
果之间的差异的检测结果能够为确定肝癌的治疗方法提供信息。

[0151] 另外，本发明提供一种用于预测肝癌预后的方法，所述方法包括：(A)检测获自肝癌患者的样品中的选自由上表2所示的基因组成的组的一种或至少两种基因(已在对本发
明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)
的表达水平或表达模式中的一项或多项；和(B)将步骤(A)的结果与对照组的测量结果进
行比较，从而预测肝癌预后。

[0152] 上述由基因组成的组还可以包含上表3所示的基因(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)。

[0153] 除非存在矛盾，针对本发明的用于根据肝癌分期来预测预后的肝癌预后预测方法而提及的内容也等同地适用于上述方法。

[0154] 此外，除非存在矛盾，针对本发明的组合物或试剂盒而提及的内容也等同地适用于本发明的方法。

[0155] 本发明的预测肝癌预后的方法可以是为预测肝癌预后提供信息的方法。

[0156] 此外，本发明提供包含在本发明的组合物中的核酸或抗体在预测肝癌预后中的应用。

[0157] 此外，本发明提供用于预测肝癌预后的核酸或抗体，且所述核酸或抗体是包含在本发明的组合物中的核酸或抗体。

[0158] 除非存在矛盾，针对本发明的标志物、组合物或试剂盒、方法和用途而提及的内容都等同地适用。

[0159] 发明效果

[0160] 本发明的标志物、组合物或试剂盒以及方法使得可以有效地预测肝癌预后、优选根据分期来有效地预测肝癌预后。
附图说明

[0161] 图1图示了BCLC分类表。

[0162] 图2～图106是Kaplan-Meier曲线，其图示了通过在复发、存活和无病存活方面测量本发明的肝癌预后标志物而得到的数据。

[0163] 具体实施方式

[0164] 下文中，将借助于实施例来详细说明本发明；但描述这些实施例仅是为了帮助理解本发明，而不是以任何方式限制本发明的范围。

[0165] 实施例1：预测肝癌预后

[0166] 用下述方法发现了可用于预测肝癌预后的标志物，经确认，使用这些标志物可以预测肝癌预后。

[0167] 1-1.RNA抽提和cDNA合成

[0168] 从547位肝癌患者(已诊断出其出现肝癌，并确认了其肝癌的发展)中采集肝癌组织和附近的正常组织。这些肝癌患者是在诊断后经历了癌症肝脏切除术但没有接受其他
治疗的患者，所述组织是在所述癌症肝脏切除术前采集并冷冻的组织。

[0169] 抽提每份组织的RNA，并按照下述方法合成cDNA。

[0170] 按照制造商的使用说明，使用RNeasy Minikit(Qiagen，德国)从肝癌组织和附近的正常组织中抽提出总RNA。使用Bioanalyzer2100(Agilent Technologies，美国)对所
获得的RNA抽提物的总RNA进行称重。在抽提步骤中进行DNA酶I处理，以将污染了的基
因组DNA从RNA抽提物中除去。将包含4μg总RNA的样品与2μl的10μM寡聚d(T)18
引物(Genotech，韩国)在70℃温育7分钟，随后在冰上冷却5分钟。单独制备酶混合物
[总体积11μl，制备方法为：添加2μl0.1M的DTT(Duchefa，荷兰)、2μl10×逆转录缓
冲液、5μl2mM的dNTP、1μl200U/μl的MMLV逆转录酶和1μl40U/μl的RNA酶抑制剂
(Enzynomics，韩国)]。将该酶混合物添加到包含RNA的样品中，之后将其在42℃温育90
分钟，而后在80℃温育10分钟，从而使逆转录酶失活。添加用焦碳酸二乙酯(DEPC)处理过
的水使上述样品的最终体积为400μl。

[0171] 1-2：定量实时PCR

[0172] 按照制造商的使用说明，在下表所示的基因标志物的存在下，使用PRISM7900HT(Applied Biosystems，美国)对从实施例1-1获得的每个cDNA样品进行实时
PCR扩增。

[0173] 该实时PCR分析在10μl的总体积中进行，其中包含5μl的2×Taqman基因表达主混合物(Applied Biosystems，美国)、5μM的正向引物和反向引物各1μl、1μl的1μM
探针(Genotech，韩国)和2μl的cDNA(在对照组中为等量的水)。上述扩增以以下步骤组
成的循环来进行：在95℃进行10分钟的解链步骤，之后是在95℃进行15秒的解链步骤，以
及在60℃进行1分钟的合成步骤。使用Primer Express3.0(Applied Biosystems，美国)
来设计引物和探针的序列，并用FAM标记所有探针序列的5′末端，用TAMRA标记所有探针
序列的3′末端。将下表16中的以下引物和探针序列用于每种标志物。

[0174] [表16]

[0175]) )
96(C 27(G )57 ) )18( ) ) )69
)36( TCCC ACAA (CCC 87(G CCCA 48(A )7 ) 39(T (TTT )
)06( CATC )66 ATTG GCAA TTGG ACCT CGTA CTTC 8(AC 09(C GTGG CGTA 99(A
GCCA CTCA (CCC ACCG AGGA TAGT TTAC ACCC TCCA CGGC CTTA TCGG CTAT ACAA
).oN DI QES(针 CGGGCCTCTCCCGAAG GCCACCGGTCCTCCTA GTCGCGGACCCAGTCG AACTTGAACTGCCTAC GACAAAGCTAAAAACC GATACACCCGACTCTA TGTCCCCTCTCTTCCG TAGGAACTTGAAGAAA CACCCACCGTTGAGAC TCAAGGCGTCAAAGAC GCCGCGAAGTCACGCT CACTCAAGTCTCCGTC TACACGGTCCTCCTGG GACCCCCTACGACCCG
探 A C A T C C T A T C C T T T
)5 ) ) ) )
)26 6(TT ) 17(G 47(G )77 38(C ) 59(A )8
).ON DI QES( )95(TGAGAGGATGGG (TTGTTATAGGTGGGT CTGGTTCAAATAGACA 86(CGATAGGTGTAGT TAAACGTTCTCTCTGT AGATGAATCGTACAGG (GTAGTTACACTTTCA )08(AGGAAGCCGGAA TAACAGTGTGAAAATC )68(TTTCCACGGG )98(ACGTTCCGAC 29(GGTTATTCCACCC CAAAAACCATCACCAT 9(TTCCACTCGTTCTA
物引 TCGC TGTG CACT CTGT CAAT GATG GTCC GAAG TGGT TTCA ACCA CTGT AGTT CCTT
向反 TCGT TTCG GTGG CGGG GACC GCTC CAGT GAGA TCGT GCCG GCCA ACAC AGGT TAGG
)76 )37 )2 ) ) )7
)85( ) )4 (GTT )07 (TGA ) 8(AA )58 ) 19(T 49(T 9(AA
).ON DI QES(物 AAGAACCGATCCCACG 16(ACTTGAGCCGAAG 6(TACGAGGACCGAGA CATGAGTGTGGAACCT (AGACACCCTGCCATC CACGTCACTGAAGTCT )67(ACAGTCAGGGCC 97(GTATTGCCCGGAA AAACACAAGCACCTCC (ACTTAACGGAAGCAG 88(ATTCTGATCCCCG TAGACCATCTGTGCCT CGTACATGGTCAAGTC CTCGAACCTCATCGTC
引向 TGTA ACGG GACC TTGG CGAA GTTG TCCG CAGG AAAA AAGG CCCC GAGC CGTC AGCA
正 A C G T C G T C A C G C T A
1 1P
因 GAR TPM 3TA 2PA 4EHL 2P 2NS 1BG 1TR B91S 2PM RE 3NS 2
基 VU AN TS IC HB MM ES MH IS PR AL GA ES DI
)201
(GTC
GTCT
TTAT
CGCT
CTCT
GTGC
CCTG
A
)
101(
AGGA
TCTG
ACTC
GTAA
CGTA
AAGA
)
001(
TTTG
GTCT
CTGG
TTTC
CGTC
G
3F
CT

[0176]) ) ) )
)5 711( ) 531( 831( 141( )
01(G )8 ) )41 GTCC )0 )3 621( ) )231 GCGG CACT CCTA 741(
CTTT 01(C 111( 1(CC CATG 21(C 21(C GTGA 921( (ACA TTCT TCGA ACCC )44 CCAG
AACT AACC CGGT TACG TCCG AGCC TGGT ACAC AGTA GTTC TATT CAAC CCGT 1(GC GGTC
GCCT TCCC GGTA AGAC GGTG CTGC CCTC CTGC TTCC CTGC ATTG CGTG TTTA CGGG ACCC
TCTC CTAC ACGC CGCA CAGA GAAG CGTC CCTT GCCC CCTG GTCC AAAG TTCC ACGA CTAA
AGGC CGCC ACGT GAGG ACAT ACGT CGTC CTCG CGAC GGAC ACGA ACAC CAAA CTCC ATGT
CCAC CACT CCTC GAAC ACTT CCCT TCCG TCGT ACCC AACG CACC CTGT AGTA CCCA ACCG
A A C C T C T A C A T A A C T
) )13 )341
)401 311( ) )22 )52 ) 1(AT )4 ) ) (CAG )64
(GTT )701 )0 ACTT )611 911( 1(TG 1(GA 821( GTCC 31(T 731( 041( ATCT 1(CA
CTTC (AGG 11(A CGTC (AGA CAGT AAAT ACTC GATA TGAC TTCC GACT AAGT CTGA AGAC
ACAA AAGG CTCT TAAT CAGA TACC TTCC AAAA CTTC TCTT TACC AACC ACGG GACC CTCC
GCCT TCGT CTTA TCAA CGGG TCTA GACA CCGA CTTC CTTC GAGG CCTC CCAT TCGA TTTC
CTCT CAGC GCGG AAAC TCGA CACG CGTC CCGG GCCA ATTT ACCA CGTA GGTA CCTA CCTC
ACCT TCGT CGGG GACC GCTG CGTA GAGG AATA AGGC TGGC AGTA GACT CAAC TTGA CTCA
)7 ) )
)601 )90 )211 )8 )121 )421 21(G 031( )33 631( )9
)301 (TCT 1(CG (GTG )51 11(C (TCT (ACT TCAT TTCT 1(GT ACTT 31(T )241 )541
(AAC CTCG TAAC TTTC 1(AC GTAA CTGA GACC AGTC CCTC TCTT AGAC CAAC (ACG (TTC
ACGA TAGC ACCC TCGT AAGC GCGA CTTA GGTA GGCG CGTT CAGC GCTC TGAC ATCA GTCC
GAAG TTCC CTGT ACGT ACCG CTCA CGTG GTAT AAAG CGAC CGGA TCTG TCCG CCCT TGCC
GGCC ACCT TTAA TGTT GCCC CGGT GGTC GACC TCTA CTAG GGTG TGGT CCCA GCGC CTCG
GT CG CC GC AG AG CT CT AA AG AC AG CG CT GG
76
2BG 36 EG 91AA 1BT ROTP 1NS 2GN 1H GLS 3PS 1NC 2H 1TSI 9P
MH PT AR IK AS AR ES CC DC AF AC EB DC WT MM
)
) ) )471 )08 681( )29
)05 351( )65 )261 861( )171 (ACA 1(CC ) GGCC )981 1(TT
1(CG CGGC 1(GG )951 (GGA )56 CTAG (GTC CCCC )77 ACTT 381( ATTC (CAG AGTC
GCCC CTCA CCCT (AGC TGCA 1(AC ACCA CACC GAAG 1(CA GACT CCAA AGAA GAAG CACC
TGTA TCCC CTCG CTCT CACT AGGC CTCC CACT TCAG CCGG TGTG CTGC AGTA CAAC CGAA
GACG CCTG ACCA CGTC GCCG GCTA GTGT GTCA AAGT CACG TACC ACGG CAGT AACC CAGC
GTCA CGTT CGTG CGCG GTCT CCCG TCGG CTAC ACTT CGAA CTCC GCCT GTCG GGTA GGTT
CCAG AATG GAGA TCGA CCGA CACC GTTC GGTC ACAA GCCC ACCA CTCG ACTC CCAC TATC
A T A C A T T C C A C T C C T
)
) )85 )1 )46 761( )0 )2 ) )
)941 )2 551( 1(AC 61(G 1(AT AAGA 71(A )371 )671 )971 81(C 581( )88 191(
(ACA 51(A TTCG AGTC TACT GCTC AAGT TTGG (TAA (TCG (TAC TATG ACTT 1(AA ACTA
ACCT GGAA TCTT CTGG TCCA GTCC GCCA CCCA CCGT TACT GTCC CCCT CGAC AGAG GTAG
TCTT ACGC TGGT AAGC GTGA TCTT AACT TGGT TTGG CCTT GTAC TGTT TTTG GGAC TGGA
CGTC TGCG TCGA ATCG GCAC TCTG ATTA TCTT GTGA GTGC GACT GTGG GAAA CACC CTGA
GGGT AGGG CCGT TAAC CACT CTCC CAGG CACC CGTC TCGC CCAC AGGT CCGG GCTC GCCG
)
) ) 271(
841( )1 )451 )751 061( ) )9 TATC )87 )1 )4 )781 )09
TTGA 51(C (GTC (TGT AAAC 361( )66 61(G AAAC )57 1(GT 81(A 81(A (TTA 1(AA
GTCT AGTA AAAG CTAT ATTC TGAG 1(AA ATGA CGAT 1(TC CTAC TCCT ATTA TTGA TACT
TCGT AGTT TGGT AAGT CGAA TGGT CCTC CGTG GAAG CTTG TCCC CTAT CTAC AACG CTAC
CCAC TAGC CGAC AGTC TTTA ACGA CGAG ACCT TAAC AGGA ACTA TACT CGTC CTCT CATC
TCTC TTCG TTAC CACC GACT CACG TAAG GTGT TCTA ACCC AAAG TCCG ACCT AGTG CGTT
ATTC ACAG ACTA AGGT CACG ACCA TAGG CGGA GAAG CCCT TTAC CCGA CCTT GAGT GACG
G C A C T A C G T T C C T T G
FG 21G OLBA 1F 1PM 3 7G T 1MF 3PI 3G MA 5G TM 1AAK
EV TA ID 2E AL CL TA KT IA NB TA RD TA NN RP
) )4 )7 )
102( 02(A 02(A 222( )822
)591 )8 CCTC AGAC CTGA )0 )3 )612 )91 CAGC ) (CCG
(GGA 91(C TCAC AAGA CACG 12(C 12(A (TCC 2(TG ACAC 522( TCCC
CCCG AACT CCCC CGAC GTCC CGCG CCCG CGGA TCCC CCAG CACG AAGG
CTGT CCGC CTTT ACAG ACTT GTTT AGCT ACTC GCTA GACT CTCT AGCC
CTCG GGGT TACT AACC AAAA GTCG CTCC GTGG CAAC TAAC CGGA CATA
CTCT CCTG AGTT TGTA CCCC ACCT TGTC TCAA AGGT CTCC CGGG TACC
AAGA GACG AAGA ACAG AATA AACG GCAC ACGA GGTC TTAT TCGC ACAG
C A C T A T C C C A A A
)3 ) )
)791 )00 02(A )60 902( )21 )8 122( )722
)49 (AGA 2(GT GTAC 2(AA ACCT 2(AC )51 12(A AGTA )422 (AAG
1(CA GAAC GATT CTTT GTGT ACTG CTTT 2(TG CTGA CATG (CTC TCTT
CTAG TATC GGAC CTTT TCAA ATGG CTGC GTTC CTCA AAAC TACC GACC
AGCC ACGA CCAA CTTC CAGA ACGT AAAA CACG TGGA TCAA TGGT GGTC
GAGT CCTG GGGA GCAT TGGC AAAT ACAC GCCT CTTG GGGA GAAG TGAT
GGCG GGAA AAGG ACTG GGAC GACG GACA TGAC GCCG GTCG CGGG ACGA
)
391( )991 )20 )50 ) ) )41 ) )32 )6
GTTT (TGT 2(TA 2(GG 802( 112( 2(GT 712( )0 2(AC 22(G
TATC )6 TTGT AAAC TAAA AACT AAGA TTCA AACT 22(C GAAC TACA
GTGG 91(T AGTT CGAA CTGG ATCT GAGT TCTT GCGA CTAA ATCT CAGA
TAGT GTAC TTGT GTAA ATGT CTGT TTAC TTCC GAGG CGTT ACTG GTCT
TAGT GCCG TTCC CTGT CCTA TACG GTGG CGCT TGTG CAAG AAAC ACCG
CTTC GCGC GTTA GGTA GTAC CCGG GCTC GTTG TGTA GCGG GGTT GACA
C T G A G A T G C T G G
8PS 1K 1L2L S L1E 1PA 1T X 2L NE S PA
AC LU CB AF SC RF KA AB CB TP BC IX

[0177] 每种标志基因的表达都平行测量3次，随后通过减去5种参照基因(B2M、GAPDH、HMBS、HPRT1和SDHA)的平均表达来进行标准化。将下表17中的引物和探针序列用于参照
基因。

[0178] [表17]

[0179]

[0180] 测量每种标志物的CT(达到阈值所需的循环数)，并计算ΔCT值(每种标志物的-ΔCT
CT减去参照基因的平均CT)。mRNA的拷贝数以2 计算。使用对cDNA样品的梯度稀释液
进行同时扩增的结果构建了标准曲线。

[0181] 从以上结果可以看出，利用包含在本发明的组合物中的核酸，可以测量标志物的表达水平和表达模式。此外，由于mRNA作为转录本被翻译成蛋白，还可以推知，利用包含在
本发明的组合物中的抗体，还可以测量标志物的表达水平和表达模式。

[0182] 1-3.统计学分析

[0183] 考虑到从实施例1和2获得的每种标志物的标准化表达以及提供肝癌组织的患者的进展，完成了Kaplan-Meier曲线，并随后进行了显著性分析。

[0184] 基于提供了肝癌组织的患者的进展，对于复发、存活和无病存活的各种情况，按时期升序排列了患者。通过用存活者(或复发的患者)的数量除以面临风险的患者数量，计
算出了区间存活率(或区间复发率)。累积存活率(或累积复发率)为条件概率，其通过以
下方法来计算：用之前的累积存活率(或累积复发率)乘以当前的区间存活率(或区间复
发率)。Kaplan-Meier曲线被构建为阶跃函数，其中横轴为存活时间(或观察期)，纵轴为
累积存活率(或累积复发率)。

[0185] 对于每种标志物，完成了对应于复发、存活和无病存活的Kaplan-Meier曲线。根据经实验确定的在统计学上具有显著性的参照值，将在实施例1和2中测得的每种标志物
的表达分类为高表达和低表达，并使每种标志物的高表达情形和低表达情形彼此分开，从
而完成Kaplan-Meier曲线。作为所述参照值，选择了在连续变量的回归分析结果中具有最
低p值的基因表达值(见N Engl J Med2007；356：11-20)。将这些值用于Kaplan-Meier
曲线以绘制成图(J.Amer.Statist.Assn.53：457481，1958)。用于确定Kaplan-Meier曲线
中的显著性的标准是单基因或基因组合的p值是否低于0.05。

[0186] 绘制Kaplan-Meier曲线是为了在547位分期尚未得到归类的肝癌患者中针对57种单基因、31种单基因和其中的至少两种的组合组成的基因的组来预测复发、存活和无病
存活。将57种单基因的结果示于图2～22中。57种单基因的关于复发的Kaplan-Meier
曲线示于图2～8中，57种单基因的关于存活的Kaplan-Meier曲线示于图9～15中，57
种单基因的关于无病存活的Kaplan-Meier曲线示于图16～22中。

[0187] 从这些图中可以确认，在针对复发、存活和无病存活而完成的Kaplan-Meier曲线中，每种标志物都形成了高表达情形和低表达情形彼此明显区分开的曲线。这意味着，在每
种标志物显示出高表达和低表达的情形之间，在区间复发率或区间存活率方面以及在基于
其的累积复发率或累积存活率方面都有明显差异，因此，每种标志物的表达模式都可以作
为显示出患者的复发可能性或存活可能性的指数。

[0188] 此外，显著性检验以下述方式进行：通过计算每个复发点或死亡点处的观察值和2
预期值，对每种标记物及其组合进行时序检验，从而获得χ 检验统计数字。其结果示于下
表18～21中。57种标志物的结果示于表18中，单独使用或组合使用的31种标志物的结
果示于表19～21中。其中，表19示出了31种标志物的复发预测结果，表20示出了31种
标志物的存活预测结果，表21示出了31种标志物的无病存活预测结果。

[0189] [表18]

[0190]

[0191]

[0192] [表19]

[0193]

[0194]

[0195]

[0196] [表20]

[0197]

[0198]

[0199] [表21]

[0200]

[0201]

[0202]

[0203] 在复发、存活和无病存活方面，每种标志物或其组合都显示出了足够低以至于可以认为具有显著性的p值。特别而言，在两种以上标志物组合的情况中，针对复发、存活和
无病存活的所有p值都小于0.05，这是想要的结果。p值越低，统计学显著性就越高。因此，
低p值意味着，利用每种标志物或其组合对肝癌预后进行的预估是非常准确的。

[0204] 从以上结果可以发现，所组合的本发明的标记物越多，p值就越低。这意味着，所组合的本发明的标记物越多，所显示出的p值就越低，即显著性就越高，也就意味着，在基
于这些标志物的组合对预后进行预估时所获得的准确性会提高更多。

[0205] 此外可以发现，使用本发明的针对这些标志物的预测肝癌预后的方法，可以有效地预测A2组的肝癌预后。

[0206] 另外，对31种基因进行了交叉验证。在该交叉验证中，将未根据分期分类的患者随机分为两组(阳性组：274位患者；测试组：273位患者)。在阳性组的认为具有统计学显
著性的参照值固定的情况下，对于测试组，经计算，对复发、存活和无病存活的预估准确性
在p＜0.05或p＜0.001的水平。

[0207] 在所有未根据分期进行分类的患者中针对31种基因中的两种以上的组合对复发、存活和无病存活进行了预测，在对该预测的交叉验证结果中，在各方面都显示出优异的
预后准确性的代表性实例如下：

[0208] 复发：ATG3_FASLG_ID2_RPS19BP1_SESN3_TCF3(94％在p＜0.05的水平)

[0209] 存活：CSE1L_FAS_FRAP1_CDH1_BHLHE41_SESN2(95％在p＜0.0001的水平)

[0210] 无病存活：ATG12_FASLG_ID2_STAT3_RPS19BP1_TCF3(95.0％在p＜0.05的水平)

[0211] 实施例2：在A1组中预测肝癌预后

[0212] 以与实施例1中相同的方式进行实验，不同之处在于：对经确定属于A1组(门静脉侵袭阴性患者组，BCLC(巴塞罗那临床肝癌)分期系统的0期或A期，具有1个尺寸为5cm
以下的肿瘤或3个以下的尺寸为3cm以下的肿瘤)的患者(277位患者)进行实验。绘制
了Kaplan-Meier曲线来预测复发、存活和无病存活，其结果示于图23～43中。针对复发
的Kaplan-Meier曲线示于图23～29中，针对存活的Kaplan-Meier曲线示于图30～36
中，针对无病存活的Kaplan-Meier曲线示于图37～43中。

[0213] 从这些图中可以看出，在针对复发、存活和无病存活而完成的Kaplan-Meier曲线中，上述标志物形成了高表达情形和低表达情形彼此明显区分开的曲线。这意味着，在所述
标志物为高表达和低表达的情形之间，在区间复发率或区间存活率方面以及在基于其的累
积复发率或累积存活率方面都有明显差异，因此，所述标志物的表达模式可以作为显示出
患者的复发可能性或存活可能性的指数。

[0214] 此外，显著性检验以下述方式进行：通过计算每个复发点或死亡点处的观察值和预期值，对每种标记物及其组合进行时序检验，从而获得p值。其结果示于下表22～29中。
仅使用一种标记物的结果示于表22中，两种标记物组合的结果示于表23中，三种标记物组
合的结果示于表24中，四种标记物组合的结果示于表25中，五种标记物组合的结果示于表
26中，六种标记物组合的结果示于表27中，七种标记物组合的结果示于表28中，八种标记
物组合的结果示于表29中。

[0215] [表22]

[0216]

[0217]

[0218] [表23]

[0219]

[0220]

[0221] [表24]

[0222]

[0223]

[0224] [表25]

[0225]

[0226]

[0227] [表26]

[0228]

[0229]

[0230] [表27]

[0231]

[0232]

[0233] [表28]

[0234]

[0235]

[0236] [表29]

[0237]

[0238]

[0239]

[0240] 从以上表中可以确定，在复发、存活和无病存活方面，每种标志物或其组合都显示出了足够低以至于可以认为具有显著性的p值。特别而言，在两种以上标志物组合的情况
中，针对复发、存活和无病存活的所有p值都较低。特别而言，发现了这种情况：单基因的p
值相对高，但是当将该标志物与其他标志物组合使用时p值有所下降。p值越低，统计学显
著性就越高。因此，低p值意味着，利用每种标志物或其组合对肝癌预后进行的预估是非常
准确的。

[0241] 这意味着，所组合的本发明的标记物越多，所显示出的p值就越低，即显著性就越高，换言之，在基于这些标志物的组合对预后进行预估时，所获得的准确性会提高更多。

[0242] 因此发现，表22～29中的标志物和/或标志物组合在预测A1组的肝癌预后(复发、存活和无病存活)时有效，利用针对这些标志物的核酸和抗体可以有效地预测A1组的
肝癌预后。

[0243] 还可以发现，使用本发明的针对这些标志物的预测肝癌预后的方法，可以有效地预测A1组的肝癌预后。

[0244] 此外，对认为具有统计学显著性的标志物组合进行交叉验证。将每个患者组的患者随机分为两组(阳性组：139位患者；测试组：138位患者)。在阳性组结果(以与实施例
1相同的方式获得)中的认为具有统计学显著性的参照值固定的情况下，对于测试组，经计
算，对复发、存活和无病存活的预估准确性在p＜0.05或p＜0.001的水平。

[0245] 在对A1组的复发、存活和无病存活的预测进行的交叉验证结果中，在各方面都显示出优异的预后准确性的代表性实例如下：

[0246] 复发：ATG7_FRAP1_LC3_NNMT_STAT3(95％在p＜0.05的水平)

[0247] 存活：AKT1_CDH1_ID2(98.7％在p＜0.05的水平)

[0248] 无病存活：FRAP1_LC3_TKT_HMGB1_STAT3_TWIST1(84.0％在p＜0.05的水平)

[0249] 实施例3：在A2组中预测肝癌预后

[0250] 以与实施例1中相同的方式进行实验，不同之处在于：对经确定属于A2组{门静脉侵袭阴性患者组，具有尺寸大于5cm的肿瘤}的患者(123位患者)进行实验，以与实施
例1中相同的方式进行实验。绘制了Kaplan-Meier曲线来预测复发、存活和无病存活，其
结果示于图44～46中。针对复发的Kaplan-Meier曲线示于图44～50中，针对存活的
Kaplan-Meier曲线示于图51～57中，针对无病存活的Kaplan-Meier曲线示于图58～64
中。

[0251] 从这些图中可以看出，在针对复发、存活和无病存活而完成的Kaplan-Meier曲线中，上述标志物形成了高表达情形和低表达情形彼此明显区分开的曲线。这意味着，在所述
标志物为高表达和低表达的情形之间，在区间复发率或区间存活率方面以及在基于其的累
积复发率或累积存活率方面都有明显差异，因此，所述标志物的表达模式可以作为显示出
患者的复发可能性或存活可能性的指数。

[0252] 此外，显著性检验以下述方式进行：通过计算每个复发点或死亡点处的观察值和预期值，对每种标记物及其组合进行时序检验，从而获得p值。其结果示于下表30～37中。
仅使用一种标记物的结果示于表30中，两种标记物组合的结果示于表31中，三种标记物组
合的结果示于表32中，四种标记物组合的结果示于表33中，五种标记物组合的结果示于表
34中，六种标记物组合的结果示于表35中，七种标记物组合的结果示于表36中，八种标记
物组合的结果示于表37中。

[0253] [表30]

[0254]

[0255]

[0256] [表31]

[0257]

[0258]

[0259] [表32]

[0260]

[0261]

[0262] [表33]

[0263]

[0264]

[0265] [表34]

[0266]

[0267]

[0268] [表35]

[0269]

[0270]

[0271]

[0272] [表36]

[0273]

[0274]

[0275] [表37]

[0276]

[0277]

[0278]

[0279] 从以上表中可以确定，在复发、存活和无病存活方面，每种标志物或其组合都显示出了足够低以至于可以认为具有显著性的p值。特别而言，在两种以上标志物组合的情况
中，针对复发、存活和无病存活的所有p值都较低。特别而言，发现了这种情况：单基因的p
值相对高，但是当将该标志物与其他标志物组合使用时p值有所下降。p值越低，统计学显
著性就越高。因此，低p值意味着，利用每种标志物或其组合对肝癌预后进行的预估是非常
准确的。

[0280] 这意味着，所组合的本发明的标记物越多，所显示出的p值就越低，即显著性就越高，也就是说，在基于这些标志物的组合对预后进行估计时，所获得的准确性会提高更多。

[0281] 因此发现，表30～37中的标志物和/或标志物组合在预测A2组的肝癌预后(复发、存活和无病存活)时有效，利用针对这些标志物的核酸和抗体可以有效地预测A2组的
肝癌预后。

[0282] 此外可以发现，使用本发明的针对这些标志物的预测肝癌预后的方法，可以有效地预测A2组的肝癌预后。

[0283] 此外，对认为具有统计学显著性的标志物组合进行了交叉验证。将每个患者组的患者随机分为两组(阳性组：62位患者；测试组：61位患者)。在阳性组结果(以与实施例
1相同的方式获得)中的认为具有统计学显著性的参照值固定的情况下，对于测试组，经计
算，对复发、存活和无病存活的预估准确性在p＜0.05或p＜0.001的水平。

[0284] 在对A2组的复发、存活和无病存活的预测进行的交叉验证结果中，在各方面都显示出优异的预后准确性的代表性实例如下：

[0285] 复发：TKT_SESN2_VEGF(65.0％在p＜0.05的水平)

[0286] 存活：DIABLO_FAS_LAMP1_BHLHE41_SESN2(83.3％在p＜0.05的水平)

[0287] 无病存活：TKT_SESN2_VEGF(82.0％在p＜0.05的水平)

[0288] 实施例4：在B组中预测肝癌预后

[0289] 以与实施例1中相同的方式进行实验，不同之处在于：对经确定属于B组{门静脉侵袭阴性患者组，BCLC分期系统的中期，具有多个尺寸大于3cm的肿瘤或数量大于3的多
个肿瘤}的患者(78位患者)进行实验。绘制了Kaplan-Meier曲线来预测复发、存活和无
病存活，其结果示于图65～85中。针对复发的Kaplan-Meier曲线示于图65～71中，针
对存活的Kaplan-Meier曲线示于图72～78中，针对无病存活的Kaplan-Meier曲线示于
图79～85中。

[0290] 从这些图中可以看出，在针对复发、存活和无病存活而完成的Kaplan-Meier曲线中，上述标志物形成了高表达情形和低表达情形彼此明显区分开的曲线。这意味着，在所述
标志物为高表达和低表达的情形之间，在区间复发率或区间存活率方面以及在基于其的累
积复发率或累积存活率方面都有明显差异，因此，所述标志物的表达模式可以作为显示出
患者的复发可能性或存活可能性的指数。

[0291] 此外，显著性检验以下述方式进行：通过计算每个复发点或死亡点处的观察值和预期值，对每种标记物及其组合进行时序检验，从而获得p值。其结果示于下表38～45中。
仅使用一种标记物的结果示于表38中，两种标记物组合的结果示于表39中，三种标记物组
合的结果示于表40中，四种标记物组合的结果示于表41中，五种标记物组合的结果示于表
42中，六种标记物组合的结果示于表43中，七种标记物组合的结果示于表44中，八种标记
物组合的结果示于表45中。

[0292] [表38]

[0293]

[0294]

[0295] [表39]

[0296]

[0297]

[0298] [表40]

[0299]

[0300]

[0301] [表41]

[0302]

[0303]

[0304] [表42]

[0305]

[0306]

[0307] [表43]

[0308]

[0309]

[0310] [表44]

[0311]

[0312]

[0313]

[0314] [表45]

[0315]

[0316]

[0317] 从以上表中可以确定，在复发、存活和无病存活方面，每种标志物或其组合都显示出了足够低以至于可以认为具有显著性的p值。特别而言，在两种以上标志物组合的情况
中，针对复发、存活和无病存活的所有p值都较低。特别而言，发现了这种情况：单基因的p
值相对高，但是当将该标志物与其他标志物组合使用时p值有所下降。p值越低，统计学显
著性就越高。因此，低p值意味着，利用每种标志物或其组合对肝癌预后进行的预估是非常
准确的。

[0318] 这意味着，所组合的本发明的标记物越多，所显示出的p值就越低，即显著性就越高，换言之，在基于这些标志物的组合对预后进行预估时，所获得的准确性会提高更多。

[0319] 因此发现，表38～45中的标志物和/或标志物组合在预测B组的肝癌预后(复发、存活和无病存活)时有效，利用针对这些标志物的核酸和抗体可以有效地预测B组的肝
癌预后。此外可以发现，使用本发明的针对这些标志物的预测肝癌预后的方法，可以有效地
预测B组的肝癌预后。

[0320] 此外，对认为具有统计学显著性的标志物组合进行了交叉验证。将每个患者组的患者随机分为两组(阳性组：39位患者；测试组：39位患者)。在阳性组结果(以与实施例
1相同的方式获得)中的认为具有统计学显著性的参照值固定的情况下，对于测试组，经计
算，对复发、存活和无病存活的预估准确性在p＜0.05或p＜0.001的水平。

[0321] 在对B组的存活预测进行的交叉验证结果中，在各方面都显示出优异的预后准确性的代表性实例如下：

[0322] 存活：DIABLO_BECN1_SIRT1(79.7％在p＜0.05的水平)

[0323] 实施例5：在C组中预测肝癌预后

[0324] 以与实施例1中相同的方式进行实验，不同之处在于：对经确定属于C组{门静脉侵袭阳性患者组，不论肿瘤尺寸和数量如何}的患者(69位患者)进行实验。绘制了
Kaplan-Meier曲线来预测复发、存活和无病存活，其结果示于图86～106中。针对复发的
Kaplan-Meier曲线示于图86～92中，针对存活的Kaplan-Meier曲线示于图93～99中，
针对无病存活的Kaplan-Meier曲线示于图100～106中。

[0325] 从这些图中可以看出，在针对复发、存活和无病存活而完成的Kaplan-Meier曲线中，上述标志物形成了高表达情形和低表达情形彼此明显区分开的曲线。这意味着，在所述
标志物为高表达和低表达的情形之间，在区间复发率或区间存活率方面以及在基于其的累
积复发率或累积存活率方面都有明显差异，因此，所述标志物的表达模式可以作为显示出
患者的复发可能性或存活可能性的指数。

[0326] 此外，显著性检验以下述方式进行：通过计算每个复发点或死亡点处的观察值和预期值，对每种标记物及其组合进行时序检验，从而获得p值。其结果示于下表46～53中。
仅使用一种标记物的结果示于表46中，两种标记物组合的结果示于表47中，三种标记物组
合的结果示于表48中，四种标记物组合的结果示于表49中，五种标记物组合的结果示于表
50中，六种标记物组合的结果示于表51中，七种标记物组合的结果示于表52中，八种标记
物组合的结果示于表53中。

[0327] [表46]

[0328]

[0329]

[0330] [表47]

[0331]

[0332]

[0333] [表48]

[0334]

[0335]

[0336] [表49]

[0337]

[0338]

[0339] [表50]

[0340]

[0341]

[0342] [表51]

[0343]

[0344]

[0345] [表52]

[0346]

[0347]

[0348] [表53]

[0349]

[0350]

[0351]

[0352] 以上各表呈现了每种基因及其组合的p值。

[0353] 从以上表中可以确定，在复发、存活和无病存活方面，每种标志物或其组合都显示出了足够低以至于可以认为具有显著性的p值。特别而言，在两种以上标志物组合的情况
中，针对复发、存活和无病存活的所有p值都较低。特别而言，发现了这种情况：单基因的p
值相对高，但是当将该标志物与其他标志物组合使用时p值有所下降。p值越低，统计学显
著性就越高。因此，低p值意味着，利用每种标志物或其组合对肝癌预后进行的预估是非常
准确的。

[0354] 这意味着，所组合的本发明的标记物越多，所显示出的p值就越低，即显著性就越高，也就是说，在基于这些标志物的组合对预后进行估计时，所获得的准确性会提高更多。

[0355] 因此发现，表41～48中的标志物和/或标志物组合在预测C组的肝癌预后(复发、存活和无病存活)时有效，利用针对这些标志物的核酸和抗体可以有效地预测C组的肝
癌预后。此外可以发现，使用本发明的针对这些标志物的预测肝癌预后的方法，可以有效地
预测C组的肝癌预后。

[0356] 此外，对认为具有统计学显著性的标志物组合进行了交叉验证。将每个患者组的患者随机分为两组(阳性组：35位患者；测试组：34位患者)。在阳性组结果(以与实施例
1相同的方式获得)中的认为具有统计学显著性的参照值固定的情况下，对于测试组，经计
算，对复发、存活和无病存活的预估准确性在p＜0.05或p＜0.001的水平。

[0357] 在对C组的复发、存活和无病存活预测进行的交叉验证结果中，在各方面都显示出优异的预后准确性的代表性实例如下：

[0358] 复发：FAS_TCF3_FASLG_RPS19BP1(69.0％在p＜0.05的水平)

[0359] 存活：CASP3_CDH2_CIAP2(77.0％在p＜0.05的水平)

[0360] 无病存活：FAS_TCF3_FASLG(75.0％在p＜0.05的水平)

[0361] 【工业应用性】

[0362] 本发明提供用于预测肝癌预后的标志物、用于预测肝癌预后的组合物或试剂盒(优选为用于根据分期来预测肝癌的肝癌预后预测用组合物或试剂盒)以及用于预测肝癌
预后的方法。本发明的标志物、组合物或试剂盒以及方法使得可以有效地预测肝癌预后、优
选根据分期来有效地预测肝癌预后。

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预测肝癌预后的组合物或试剂盒以及预测肝癌预后的方法

预测肝癌预后的组合物或试剂盒以及预测肝癌预后的方法

技术领域

背景技术

具体实施方式

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