结肠癌的早期检测和预后
阅读：535发布：2020-07-26
专利汇可以提供结肠癌的早期检测和预后专利检索，专利查询，专利分析的服务。并且我们已经开发了全转录物组方法来鉴定在结肠直肠癌(CRC)中受到启动子CpG岛过度甲基化和转录沉默影响的基因。通过在一组原发性人类CRC样品中筛查细胞系和确认 肿瘤 特异性过度甲基化，我们估计在个体肿瘤中所有已知基因的几乎5％可能被启动子甲基化。当直接与基因突变比较时，我们在个体肿瘤中发现数量大得多的基因被过度甲基化，和在包含遗传或者外遗传变化的个体基因内高得得多的过度甲基化 频率 。因此，为了列举人类癌症基因组中的全变化谱，和有助于对肿瘤进行最有效的分组从而鉴定癌症 生物 标记并调 整治 疗方法，应该进行遗传和外遗传两种筛查。我们鉴定的基因可以用于诊断性地检测癌症、初癌和发展癌的可能性等等。，下面是结肠癌的早期检测和预后专利的具体信息内容。
1.鉴定结肠直肠癌或它的前体、或结肠直肠癌的倾向的方法，包括：
在含有结肠直肠细胞或者来自结肠直肠细胞的核酸的试样中，检测至少一种 基因的外遗传沉默，所述至少一种基因选自FOXE1、SOX17、SYNE1、BOLL、 CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化 (NEURL)、PPP1R14a、TP53AP1、RAB32、APC2、GPNMB、MMP2、EVL、 STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、 CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、 STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、 CTAG2、EPHA4、FANCF、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、 PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、 CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、 ZNF345、DKK3和ZNF655；
鉴定所述试样含有细胞，所述细胞是瘤性的、瘤的前体、或易于形成瘤，或 者鉴定所述试样含有来自细胞的核酸，所述细胞是瘤性的、瘤的前体、或易于形 成瘤。
2.权利要求1所述的方法，其中所述试样含有腺瘤细胞。
3.权利要求1所述的方法，其中所述试样含有来自腺瘤细胞的核酸。
4.权利要求1所述的方法，其中所述试样含有癌细胞或者来自癌细胞的核酸。
5.权利要求1所述的方法，其中所述至少一种基因是选自SYNE1、APC2、 GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、 ICAM5。
6.权利要求1所述的方法，还包括步骤：
在所述含有结肠直肠细胞或者来自结肠直肠细胞的核酸的试样中，检测至少 一种基因中的突变，所述至少一种基因选自FOXE1、SOX17、SYNE1、BOLL、 CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化 (NEURL)、PPP1R14a、TP53AP1、RAB32、APC2、GPNMB、MMP2、EVL、 STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、 CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、 STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、 CTAG2、EPHA4、FANCF、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、 PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、 CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、 ZNF345、DKK3和ZNF655。
7.权利要求1所述的方法，其中所述试样来自新鲜或冷冻组织样品。
8.权利要求1所述的方法，其中所述试样来自活检样品。
9.权利要求1所述的方法，其中所述试样来自手术样品。
10.权利要求1所述的方法，其中所述试样来自细胞学样品。
11.权利要求1所述的方法，其中所述试样从体液中分离，所述体液选自： 全血、骨髓、脑脊髓液、腹腔液、胸膜液、淋巴液、血清、粘液、血浆、尿液、 乳糜、粪便、精液、痰、乳头抽吸液、唾液、拭样、结肠清洗样品和刷样。
12.权利要求8所述的方法，其中向所述患者推荐外科手术去除瘤性组织。
13.权利要求8所述的方法，其中向所述患者推荐辅助化疗。
14.权利要求8所述的方法，其中向所述患者推荐辅助放射治疗。
15.权利要求11所述的方法，其中向所述患者推荐结肠镜检查或者乙状结肠 镜检查。
16.权利要求8所述的方法，其中向所述患者推荐增加频率的结肠镜检查。
17.权利要求11所述的方法，其中向所述患者推荐所述结肠的成像研究。
18.权利要求1所述的方法，其中检测至少两种基因的外遗传沉默。
19.权利要求1所述的方法，其中通过检测在所述基因中CpG二核苷酸基序 的甲基化来检测外遗传沉默。
20.权利要求1所述的方法，其中通过检测在所述基因启动子中CpG二核苷 酸基序的甲基化来检测外遗传沉默。
21.权利要求1所述的方法，其中通过检测所述基因减少的表达来检测外遗 传沉默。
22.权利要求21所述的方法，其中通过检测所述基因减少的mRNA来检测外 遗传沉默。
23.权利要求21所述的方法，其中通过与对照样品比较来测定所述基因减少 的表达。
24.权利要求22所述的方法，其中通过与核苷酸探针杂交来检测所述基因减 少的mRNA。
25.权利要求21所述的方法，其中通过核苷酸测序来检测减少的表达。
26.权利要求21所述的方法，其中通过反转录-聚合酶链式反应(RT-PCR) 来检测减少的表达。
27.权利要求26所述的方法，其中所述RT-PCR是以非定量的方式进行。
28.权利要求26所述的方法，其中所述RT-PCR是以实时和定量的方式进行。
29.权利要求21所述的方法，其中通过检测所述基因编码的减少的蛋白质来 检测外遗传沉默。
30.权利要求19所述的方法，其中甲基化通过将所述基因的至少一部分与甲 基化敏感的限制性内切核酸酶接触来检测，所述内切核酸酶相对于非甲基化的识 别位点优选地剪切甲基化的识别位点，由此所述基因的所述部分的剪切表明所述 基因的所述部分的甲基化。
31.权利要求19所述的方法，其中甲基化通过将所述基因的至少一部分与甲 基化敏感的限制性内切核酸酶接触来检测，所述内切核酸酶相对于甲基化的识别 位点优选地剪切非甲基化的识别位点，由此所述基因的所述部分的剪切表明所述 基因的所述部分的非甲基化，条件是所述基因包括所述甲基化敏感的限制性内切 核酸酶识别位点。
32.权利要求19所述的方法，其中甲基化通过如下检测：
将所述测试细胞的基因的至少一部分与化学试剂接触，所述化学试剂相对于 甲基化胞嘧啶残基选择性地修饰非甲基化的胞嘧啶残基，或相对于非甲基化胞嘧 啶残基选择性地修饰甲基化的胞嘧啶残基；和
检测由于所述接触所产生的产物。
33.权利要求32所述的方法，其中所述检测步骤包括与至少一种探针杂交， 所述探针与包括修饰的非甲基化的CpG二核苷酸基序的序列杂交，但是不与包括 非修饰的甲基化CpG二核苷酸的序列杂交。
34.权利要求32所述的方法，其中所述检测步骤包括与至少一种探针杂交， 所述探针与包括非修饰的甲基化CpG二核苷酸基序的序列杂交，但是不与包括修 饰的非甲基化CpG二核苷酸基序的序列杂交。
35.权利要求32所述的方法，其中所述检测步骤包括用至少一种引物扩增， 由此形成扩增产物，所述引物与包括修饰的非甲基化CpG二核苷酸基序的序列杂 交，但是不与包括非修饰的甲基化CpG二核苷酸基序的序列杂交。
36.权利要求32所述的方法，其中所述检测步骤包括用至少一种引物扩增， 由此形成扩增产物，所述引物与包括非修饰的甲基化CpG二核苷酸基序的序列杂 交，但是不与包括修饰的非甲基化CpG二核苷酸基序的序列杂交。
37.权利要求32所述的方法，其中所述产物通过选自电泳、杂交、扩增、引 物延伸、测序、连接酶链反应、色谱、质谱和其组合的方法来检测。
38.权利要求37所述的方法，其中所述方法是绝对检测方法。
39.权利要求37所述的方法，其中所述方法是实时检测方法。
40.权利要求37所述的方法，其中所述方法对至少两种基因进行和比较所述 至少两种基因产生的产物。
41.权利要求32所述的方法，其中所述化学试剂是肼。
42.权利要求41所述的方法，还包括用哌啶剪切所述肼接触的至少一部分的 所述基因。
43.权利要求32所述的方法，其中所述化学试剂包括亚硫酸氢盐离子。
44.权利要求43所述的方法，还包括用碱处理所述亚硫酸氢盐离子接触的至 少一部分的所述基因。
45.减少或者抑制细胞瘤性生长的方法，所述细胞显示了与癌症相关的至少 一种基因的外遗传沉默转录，所述方法包括：
确定细胞具有外遗传沉默的基因，所述基因选自FOXE1、SOX17、SYNE1、 BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、 神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、APC2、GPNMB、MMP2、 EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、 CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、 STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、 CTAG2、EPHA4、FANCF、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、 PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、 CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、 ZNF345、DKK3和ZNF655；
通过将所述细胞与一种或者多种试剂接触，恢复在所述细胞中由所述外遗传 沉默基因编码的多肽的表达，所述试剂选自CpG二核苷酸脱甲基剂、DNA甲基转 移酶抑制剂和组蛋白脱乙酰酶(HDAC)抑制剂，
由此减少或抑制所述细胞不受调节的生长。
46.权利要求45所述的方法，其中所述基因选自SYNE1、APC2、GPNMB、 MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5。
47.权利要求45所述的方法，其中所述接触在体外进行。
48.权利要求45所述的方法，其中通过将所述试剂给予含有所述细胞的哺乳 动物对象在体内进行所述接触。
49.权利要求45所述的方法，其中所述试剂是脱甲基剂，并且所述试剂选自 5-氮杂-2’-脱氧胞苷、5-氮杂-胞苷、泽布拉恩、普鲁卡因和L-乙硫氨酸。
50.减少或者抑制细胞瘤性生长的方法，所述细胞显示了至少一种与癌症相 关的基因的外遗传沉默转录，所述方法包括：
确定细胞具有外遗传沉默的基因，所述基因选自：FOXE1、SOX17、SYNE1、 BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、 神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、APC2、GPNMB、MMP2、 EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、 CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、 STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、 CTAG2、EPHA4、FANCF、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、 PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、 CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、 ZNF345、DKK3和ZNF655；
将编码多肽的多核苷酸引入所述细胞，其中所述多肽由所述基因编码，其中 所述多肽在所述细胞中表达，由此恢复所述多肽在所述细胞中的表达。
51.权利要求50所述的方法，其中所述基因选自SYNE1、APC2、GPNMB、 MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5。
52.治疗癌症患者的方法，所述方法包括：
确定在所述患者中的癌细胞有外遗传沉默的基因，所述基因选自：FOXE1、 SOX17、SYNE1、BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、 HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、APC2、GPNMB、 MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、 ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、 NEF3、POMC、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、 ATP8A2、CTAG2、EPHA4、FANCF、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、 NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、 CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、 TSPYL6、ZNF345、DKK3和ZNF655；
以足够量将一种或者多种选自CpG二核苷酸脱甲基剂、DNA甲基转移酶抑制 剂和组蛋白脱乙酰酶(HDAC)抑制剂的试剂给予所述患者，以恢复所述外遗传沉 默基因在所述患者癌细胞中的表达。
53.权利要求52所述的方法，其中所述试剂是脱甲基剂，和所述试剂选自5- 氮杂-2’-脱氧胞苷、5-氮杂-胞苷、泽布拉恩、普鲁卡因和L-乙硫氨酸。
54.权利要求52所述的方法，其中所述基因选自SYNE1、APC2、GPNMB、 MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5。
55.治疗癌症患者的方法，所述方法包括：
确定在所述患者中的癌细胞具有外遗传沉默的基因，所述基因选自：FOXE1、 SOX17、SYNE1、BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、 HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、APC2、GPNMB、 MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、 ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、 NEF3、POMC、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、 ATP8A2、CTAG2、EPHA4、FANCF、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、 NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、 CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、 TSPYL6、ZNF345、DKK3和ZNF655所示的基因；
给予所述患者编码多肽的多核苷酸，其中所述多肽由所述外遗传沉默的基因 编码，其中所述多肽在所述患者的肿瘤中表达，由此恢复所述多肽在所述癌中的 表达。
56.权利要求55所述的方法，其中所述外遗传沉默的基因选自SYNE1、APC2、 GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、 ICAM5。
57.选自治疗癌症患者的治疗策略的方法，包括：
鉴定基因，所述基因在所述患者的癌细胞中的表达被选自CpG二核苷酸脱甲 基剂、DNA甲基转移酶抑制剂和组蛋白脱乙酰酶(HDAC)抑制剂的一种或者多 种试剂再激活，其中所述基因选自FOXE1、SOX17、SYNE1、BOLL、CABYR、 EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、 PPP1R14a、TP53AP1、RAB32、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、 CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、 DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、STK31、SYCP3、 TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、 FANCF、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、 REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、 RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655； 和
选择增加所述基因表达以治疗所述癌症患者的治疗剂。
58.权利要求57所述的方法，其中所述基因选自SYNE1、APC2、GPNMB、 MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5。
59.权利要求57所述的方法，还包括为所述癌症患者开处所述治疗剂的步骤。
60.权利要求57所述的方法，还包括给予所述癌症患者所述治疗剂的步骤。
61.权利要求57所述的方法，其中所述治疗剂包括编码所述基因的多核苷酸。
62.权利要求57所述的方法，其中所述脱甲基剂是5-氮杂-2’-脱氧胞苷。
63.权利要求57所述的方法，其中所述治疗剂是5-氮杂-2’-脱氧胞苷。
64.权利要求57所述的方法，其中所述癌细胞从手术样品获得。
65.权利要求57所述的方法，其中所述癌细胞从活检样品获得。
66.权利要求57所述的方法，其中所述癌细胞从细胞学样品获得。
67.权利要求57所述的方法，其中所述癌细胞从粪便、粘液、血清、血液或 尿获得。
68.评定在试样中的甲基化的试剂盒，在包装中包括：
试剂，其(a)修饰甲基化的胞嘧啶残基，但是不修饰非甲基化的胞嘧啶残基， 或(b)修饰非甲基化的胞嘧啶残基，但是不修饰甲基化的胞嘧啶残基；和
一对寡核苷酸引物，其在扩增条件下与基因的区域特异性杂交，所述基因选 自FOXE1、SOX17、SYNE1、BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、 GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、 APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、 RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、 ICAM1、LY6K、NEF3、POMC、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、 ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXQ1、HUS1B、JAM3、 LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、 CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、 TRPC3、TSPYL6、ZNF345、DKK3和ZNF655所示的基因，其中所述区域在大约 1kb的所述基因的转录起始位点内。
69.权利要求68所述的试剂盒，其中所述基因选自SYNE1、APC2、GPNMB、 MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5。
70.权利要求68所述的试剂盒，其中所述寡核苷酸引物对中的至少一个引物 与包括修饰的非甲基化CpG二核苷酸基序的序列杂交，但是不与包括未修饰的甲 基化CpG二核苷酸基序的序列杂交，或者其中所述寡核苷酸引物对中的至少一个 引物与包括未修饰的甲基化CpG二核苷酸基序的序列杂交，但是不与包括修饰的 非甲基化CpG二核苷酸基序的序列杂交。
71.权利要求68所述的试剂盒，还包括(a)第一寡核苷酸探针，其与包括 修饰的非甲基化CpG二核苷酸基序的序列杂交，但是不与包括未修饰的甲基化 CpG二核苷酸基序的序列杂交，(b)第二寡核苷酸探针，其与包括未修饰的甲基 化CpG二核苷酸基序的序列杂交，但是不与包括修饰的非甲基化CpG二核苷酸基 序的序列杂交，或(c)所述的第一和第二寡核苷酸探针两者。
72.权利要求68所述的试剂盒，还包括(a)第一寡核苷酸探针，其与包括 修饰的非甲基化CpG二核苷酸基序的序列杂交，但是不与包括未修饰的甲基化 CpG二核苷酸基序的序列杂交，(b)第二寡核苷酸探针，其与包括未修饰的甲基 化CpG二核苷酸基序的序列杂交，但是不与包括修饰的甲基化CpG二核苷酸基 序的序列杂交，或(c)所述第一和第二寡核苷酸探针两者。
73.权利要求68所述的试剂盒，还包括寡核苷酸探针。
74.权利要求68所述的试剂盒，还包括用于扩增DNA的DNA聚合酶。
[01]本发明是使用来自国家环境卫生科学研究所(National Institute of Environmental Health Sciences)的补助金第ES11858号和来自国家癌症研究所 (National Cancer Institute)的补助金第CA043318号的美国政府资金完成的。美 国政府根据这些补助金的条款保留本发明的某些权利。
发明技术领域
[02]本发明涉及癌症诊断和治疗的领域。特别地，它涉及在结肠癌和初癌 (pre-cancer)中特定基因的异常甲基化模式(形式，pattern)。
发明背景
DNA甲基化和它在癌发生中的作用
[03]制造所有活生物的细胞的信息包含在它们的DNA中。DNA是由四个碱 基的独特序列组成，四个碱基为：腺嘌呤(A)、鸟嘌呤(G)、胸腺嘧啶(T) 和胞嘧啶(C)。在形成DNA双螺旋的两条链上，这些碱基A与T和G与C配 对。这些碱基对的链存储制造分组成被称为基因的区域的具体分子的信息。在每 一个细胞里面，具有控制什么基因被开启或表达的程序，从而确定每个细胞的独 特功能。这些控制机制之一是通过将甲基加到胞嘧啶(C)上而提供。甲基标记的 C可以写成mC。
[04]DNA甲基化在确定是否一些基因被表达或者不被表达中起到重要的作 用。通过关闭不需要的基因，DNA甲基化是生物体正常发育和发挥功能的必不可 少的控制机制。可选地，异常的DNA甲基化是引起随着老化和多种癌症的发生而 观察到的变化的机制之一。
[05]癌症在过去与在DNA内由染色体突变引起的基因变化联系起来。突变— —遗传性的或获得性的——可以导致对于维持健康状态至关重要的基因表达的丧 失。现在证据支持，相当大数量的癌症由不适宜的DNA甲基化，频繁接近的DNA 突变所引起。在许多情况下，DNA的过度甲基化不正确地关闭至关重要的基因例 如肿瘤抑制基因或者DNA修复基因，从而使得癌症能够发生和进展。这种控制基 因表达的非突变过程被描述为外因遗传学(或表观遗传学，epigenetics)。
[06]DNA甲基化是通过称为甲基转移酶的酶来进行的DNA化学修饰，在其 中甲基基团(m)被加到DNA的某些胞嘧啶(C)。这种非突变的(外遗传的) 过程(mC)是基因表达调控中的关键因素，参见J.G.Herman，Seminars in Cancer Biology，9：359-67，1999。
[07]虽然基因甲基化的现象已经引起癌症研究者的注意有一段时间，但是它 在人的癌症发展中的真正作用刚被认识到。在正常的细胞中，甲基化主要发生在 具有很少CG碱基重复的DNA区域中，而CpG岛，具有长CG碱基重复的DNA 区域，仍然保持非(未)甲基化。控制蛋白表达的基因启动子区域通常是富含CpG 岛的。在启动子区域中这些正常的非甲基化CpG岛的异常甲基化导致在人癌症中 某些肿瘤抑制基因表达的转录失活或者沉默。
[08]在肿瘤细胞中的过度甲基化的基因对于肿瘤来源的组织是非常特异的。 所有类型癌症的分子特征可以用于改进癌症的检测、癌症风险的评估和对治疗的 反应。启动子过度甲基化事件为这些目的提供了一些最有希望的标记。
启动子基因过度甲基化：有希望的肿瘤标记
[09]关于特定启动子基因的过度甲基化的信息可以有益于各种癌症的诊断、 预后和治疗。特定基因启动子区域的甲基化可以在早期和经常在癌发生中出现， 使得这些标记成为癌症诊断的理想靶标。
[10]甲基化模式是肿瘤特异的。阳性信号总是在基因的相同位置被发现。实 时PCR为基础的方法是高度灵敏的、定量的和适合于临床使用。DNA是稳定的 和发现在容易获得的流体(例如血清、痰、粪便、血液和尿)和石蜡包埋组织中 是完整的。一系列有关的基因标记可以覆盖大多数人类癌症。
诊断
[11]改善在癌症患者中的临床结果的关键是在癌症的最早阶段的诊断，在此 期间癌症仍然是局部的和容易治疗的。上文提到的特征通过在分子基础上鉴定较 高风险患者提供了更准确地筛查和监测计划的手段。它也为对患者进行更明确的 随访(follow up)提供了理由，所述患者具有与恶性病相关的分子特征，但是还没 有与恶性病相关的所有病理或者临床特征。
[12]在目前，结肠直肠癌的早期检测是通过以下几种方法来进行的：(1)“粪 便潜血试验”(FOBT)，它具有非常低的灵敏度和特异性，(2)乙状结肠镜检查 和/或结肠镜检查，它具有侵入性并且是昂贵的(以及供应有限)，(3)在双重对比 钡餐灌肠后的X射线检查，其仅允许检查相当大的息肉，或者CT-结肠镜检查(也 被称为虚拟结肠镜检查)，它仍然是实验性的，和(4)称为PreGen-Plus的基因 突变分析试验(Exact Sciences；LabCorp)，它是昂贵的且灵敏度有限。
预测治疗反应
[13]关于癌症如何通过分子事件发展的信息将使得临床医生能够更准确地预 测这种癌症对特定的化疗剂可能怎样反应。这样，根据肿瘤的化学敏感性的知识 可以理性地设计治疗方案(regimen)。研究已经显示，在神经胶质瘤患者中的 MGMT启动子的过度甲基化表明对治疗的良好反应、更大的总生存率和进展需要 更长时间。
[14]现在充分确立了，在人的癌症中正确基因功能的丧失可以通过遗传和外 遗传机制来发生(1、2)。在人的肿瘤样品中突变基因的数量正在被阐明。最近， 等(3)测序了在结肠直肠癌(CRC)和乳腺癌中的13,023个基因，发现 每个肿瘤平均11个突变，这提示了相对少量的遗传事件可能足够促使肿瘤发生。 相比之下，外遗传改变的整个图谱没有被充分描述。最详细说明的癌基因外遗传 学改变涉及在与受影响基因的转录失活相关的启动子区域中，成簇的CpG二核苷 酸或者CpG岛的DNA过度甲基化。这些启动子接近所有基因的几乎一半而定位 (4)，并且认为这些启动子在正常的体细胞组织中基本上保持无甲基化。在任何 特定的肿瘤中的这种外遗传损害的精确数量不是准确已知的，虽然不断增加数量 的随机筛查方法正在鉴定不断增加数量的候选基因(5-12)，但是这些方法中没有 一个方法有效覆盖全基因组。考虑到在基因组中存在大量潜在目标启动子，我们 假定还有很多过度甲基化的基因等待发现(13)。
[15]在本领域中有对改善患者护理管理的针对癌症的新的诊断和预后标记以 及治疗靶标的持续的需求。
发明概述
[16]依照本发明的一方面，提供鉴定结肠直肠癌或者它的前体、或结肠直肠癌 倾向的方法。在含有结肠直肠细胞或者来自结肠直肠细胞的核酸的试样中检测外 遗传沉默。外遗传沉默是选自以下的至少一个基因：BOLL、CABYR、EFEMP1、 FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、 TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、 CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、 DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、 SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、 EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、 PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、 CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、 ZNF345、DKK3和ZNF655。当外遗传沉默被检测到时，试样被鉴定为含有细胞， 所述细胞是瘤性的(增殖性的)、瘤的前体、或易于形成瘤，或者鉴定为含有来自 细胞的核酸，所述细胞是瘤性的、瘤的前体、或易于形成瘤。
[17]依照本发明的另一个方面，提供了减少或者抑制细胞瘤性(增殖性)生 长的方法，所述细胞显示了与癌症相关的至少一种基因的外遗传沉默的转录。外 遗传沉默的基因在细胞中被确定。所述基因选自BOLL、CABYR、EFEMP1、 FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、 TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、 CD109、LGR6、RET、CHD5、RNF 182、ICAM5、ARMCX2、CBR1、DDX43、 DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、 SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、 EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、 PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、 CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、 ZNF345、DKK3和ZNF655。通过将细胞与一种或者多种试剂接触恢复外遗传沉 默基因编码多肽在细胞中的表达，所述试剂选自：CpG二核苷酸脱甲基剂、DNA 甲基转移酶抑制剂和组蛋白脱乙酰酶(HDAC)抑制剂。不受调节的细胞生长因而 被减少或者抑制。
[18]本发明的另一方面是减少或抑制细胞的瘤性生长，该细胞显示了与癌症 相关的至少一种基因的外遗传沉默转录。外遗传沉默基因在细胞中被确定。所述 基因选自BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、 Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、 MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF 182、ICAM5、 ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、 NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、 ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、 LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、 CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、 TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。编码多肽的多核苷酸被引入到细 胞中。多肽被所述基因表达。多肽在细胞中被表达，因而恢复多肽在细胞中的表 达。
[19]本发明的还另一方面是治疗癌症患者的方法。患者的癌细胞被确定具有 选自以下的外遗传沉默的基因：BOLL、CABYR、EFEMP1、FBLN2、F0XL2、 GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、 SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、 RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、 HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、 TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、 FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、 REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、 RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。 一种或者多种选自CpG二核苷酸脱甲基剂、DNA甲基转移酶抑制剂和组蛋白脱乙 酰酶(HDAC)抑制剂的试剂以足够量给予患者，以恢复在患者的癌细胞中外遗传 沉默基因的表达。
[20]本发明的还另一方面是治疗癌症患者的方法。患者的癌细胞被确定具有 选自在以下显示的外遗传沉默的基因：BOLL、CABYR、EFEMP1、FBLN2、FOXL2、 GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、 SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、 RET、CHD5、RNF 182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、 HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、 TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、 FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、 REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、 RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。 编码多肽的多核苷酸被给予患者。多肽由外遗传沉默的基因编码。多肽在患者的 肿瘤中进行表达，从而恢复多肽在癌症中的表达。
[21]依照本发明的另一方面，提供了选择治疗癌症患者的治疗策略的方法。 基因被鉴定，该基因在患者癌细胞中的表达通过CpG二核苷酸脱甲基剂、DNA甲 基转移酶抑制剂或者组蛋白脱乙酰酶(HDAC)抑制剂再激活。基因选自BOLL、 CABYR、EFEMP1、FBLN2、F0XL2、GNB4、GSTM3、HoxD1、Jph3、神经化 (NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、 EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、 CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、 SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、 ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、 MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、 CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、 TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。为癌症患者选择治疗剂，该治疗 剂增加基因的表达，用于治疗所述癌症患者。
[22]本发明的另一个实施方式是评估试样中甲基化的试剂盒。试剂盒包括至 少以下试剂：(a)修饰甲基化的胞嘧啶残基、但不修饰非甲基化的胞嘧啶残基的 试剂，或者(b)修饰非甲基化的胞嘧啶残基、但不修饰甲基化的胞嘧啶残基的试 剂；和一对寡核苷酸引物，其在扩增条件下与大约1kb的所述基因转录起始位点 内的基因区域特异性杂交，所述基因选自BOLL、CABYR、EFEMP1、FBLN2、 FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、 RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、 LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、 FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、 TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、 FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、 RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、 MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3 和ZNF655中显示的基因。
附图简述和表格
[23]图1A-1E.在HCT116CRC细胞中鉴定人癌细胞的过度甲基化组 (hypermethylome)的方法。(图1A)来自标示细胞系的RNA被分离、标记、杂 交、扫描，以及荧光点强度通过减去背景来归一化和使用Agilent Technologies 44K 人微阵列进行黄土转变(Loess transformation)。在我们的研究中比较了亲本野生 型HCT116细胞(WT)和DNA甲基转移酶1(DNMT1-/-)或者3b(DNMT3b-/-) 的同基因敲除对应物。DKO细胞对于DNMT1和DNMT3b是双重缺陷的。(图 1B)在具有各种DNA甲基转移酶的遗传中断的HCT116细胞中，基因表达变化。 三维散布图以对数单位指出了在HCT116细胞中的基因表达水平，所述细胞具有 DNMTs 1(X轴)、3b(Z轴)和两种DNMT(DKO；Y轴)的遗传中断。对于 DKO细胞中具有大于4倍表达变化的那些基因，单个基因表达的变化为黑色，对 三个实验的平均值(红色点)或者来自单个实验(蓝色点)。(图1C)HCT116细 胞用300nM曲古柳菌素A(TSA)处理18小时或者用5μM的5-脱氧氮杂胞苷 (DAC)处理96小时，如前所述处理。(图1D)对于用TSA(X轴)或者DAC (Y轴)处理的HCT116细胞的基因表达变化通过倍数变化来绘图。黄色点指出 来自DKO细胞具有2倍和2倍以上变化的基因。当与在DKO细胞中看到的基因 表达增加比较时(在DKO细胞中大于2倍现在变成了在DAC处理的细胞中大于 1.3倍)，注意到敏感性的丧失。绿色点指出了随机选择的基因，其已被证实在野 生型细胞中具有完整的启动子甲基化、在DKO细胞中和在AZA处理后的重新表 达，而红色点指出了经鉴定为假阳性的选择基因(参见确认结果的图5(S2))。 蓝色点指出了11种引导基因的位置——这11种引导基因在先前表现为过度甲基 化的和在这个研究中使用的HCT 116细胞中为完全沉默的(参见图4(S1)的描 述)。包括11种引导基因中的5种的独特组的基因显示了在用DAC处理后大于2 倍的增加、而用TSA处理后没有增加。这些基因形成了在文本中讨论的候选过度 甲基化基因的顶部列。(图1E)通过树状图分析来鉴定全转录物组表达型的关联 性。DNMT1和3b、DKO的个体单个遗传中断以及DAC处理和TSA处理各自形 成三个不同类别的基因表达变化。
[24]图2A-2C.在不同的人CRC细胞系中表征人癌细胞过度甲基化组。(图 2.A)用TSA(X轴)或者DAC(Y轴)处理的指示细胞的基因表达变化通过倍数 变化来绘图，单个基因用黑色来显示。(图2B)DNA过度甲基化组的确认。由用 DAC或者TSA处理细胞来限定的过度甲基化基因的特有峰(spike)由2个具有不 同特征的层组成。上层基因鉴定为这样的区域，在该区域中，基因表达不随着TSA 增加(＜1.4倍)，并且在野生型细胞中没有显示出可检测的表达，但是用DAC处 理后有大于2倍的增加。下层的基因被鉴定为一组基因，其表达变化与在上层中 的相同、但是用DAC处理增加1.4倍至2倍之间。通过RT-PCR和MSP确认基因 表达，表明在HCT116细胞中上层基因86％的确认频率，包括在DKO细胞中增加 2倍以上的基因。在HCT116细胞中下层基因被确认在49％的频率，和在SW480 上层中具有65％的频率。(图2C)在CRC细胞系中共有的候选过度甲基化基因。 我们鉴定了在所有6个细胞系中具有落入上层或者下层类别标准的表达变化的总 共5,906个基因。指出了在2、3、4、5或者6细胞系当中基因表达变化的重叠； 这些的范围从2个细胞系中共有的1414个基因，到6个细胞系中共有的78个基 因。
[25]图3A-3E.在人肿瘤样品中过度甲基化和基因突变频率的比较。(图3A) 在人组织样品中验证的过度甲基化组基因的甲基化分析。来自验证的基因清单的 二十种基因从HCT116上层(BOLL、DDX43、DKK3、FOXL2、HoxD1、JPH3、 Nef、神经化的、PPP1R14a、RAB32、STK31、TLR2)、HCT116下层(SalL4、 TP53AP1)或者SW480上层(ZFP42)中随机地选择，并且分析在CRC细胞系(白 色柱)、正常结肠(红色柱)或者原发性肿瘤(绿色柱)中的甲基化。甲基化的 百分比在Y轴上示出，和缩写的基因名称在X轴上。我们测试了至少6种不同的 细胞系、来自非癌症患者的16到40个结肠样品和18到61个之间的原发性CRC 样品的每种基因。(图3B)CAN基因的甲基化分析。56种基因鉴定为重叠了过 度甲基化组和CAN基因列单，包括含有CpG岛的45种基因。来自这个列单的、 在细胞系中具有甲基化的选择的基因(26种基因)，被在分析在正常结肠(图3B) 和原发性CRC(图3C)中的甲基化。这些基因的甲基化频率以百分比显示。(图 3D)重叠了CAN和过度甲基化组基因列单的13种基因的甲基化和突变之间的关 系。(图3E)在人癌症中基因失活机制的模型。
[26]图4A-D.(S1).在这个研究中使用的引导基因。(图4A)先前显示在 HCT116细胞中被过度甲基化和完全沉默的11种引导基因的基因名称、Agilent Technologies探针名称、Genbank登录号和参考。(图4B)蓝色点和基因名称指出 在TSA(X轴)对DAC(Y轴)基因表达变化图中或者在(图4C)DKO(X轴) 对单个敲除(Y轴)基因表达变化的图中的11种引导基因的位置，以对数表示。 用绿色圈出的11种引导基因中的5种在用AZA处理后显示了大于2倍的增加， 但是用TSA处理后没有增加，这些同样的基因并且在DKO细胞中(绿色圆圈) 中有大于3倍的增加。(图4D)在DKO和DAC图中引导基因的直接比较。由绿 色圆圈示出的不同组的5种引导基因限定了如在本文中所讨论的候选过度甲基化 基因的上层，5种引导基因在DKO细胞中显示出大于3倍的表达变化和在DAC 处理的细胞中显示出大于2倍的表达变化。在用DAC处理后增加1.3倍的另外三 种基因和未增加的3种基因允许基因表达的下层的标准建立起来，如在文中所述。
[27]图5.(S2).在HCT116细胞中35种上层基因的基因表达和甲基化确证。 HCT116候选过度甲基化基因的清单，其被选择用于表达(通过HCT116和DKO 细胞的RT-PCR)和启动子甲基化(通过HCT116和DKO细胞的MSP)状况的确 证。基因描述在图的左边示出，基因名称在PCR结果后示出。水(RT-PCR和MSP)、 在体外甲基化DNA(MSP的IVD)和肌动蛋白B(ACTB)用为每一单个基因的 对照；显示了代表性的样品。绿色箭头鉴定验证了阵列结果的基因，红色箭头鉴 定那些没有验证阵列结果的基因。
[28]图6.(S3.)35种HCT116候选下层基因的清单，其被选择用于确证表达 (通过HCT116和DKO细胞的RT-PCR)和启动子甲基化(通过HCT116和DKO 细胞的MSP)状况。在图的左边示出了基因名称，基因名称在PCR结果后面显示。 水(RT-PCR和MSP)、体外甲基化DNA(MSP的IVD)和肌动蛋白B(ACTB) 用作每一单个基因的对照；显示了代表性的样品。绿色箭头鉴定验证了阵列结果 的基因，红色箭头鉴定那些没有验证阵列结果的基因，如文中所论述地。
[29]图7.(S4.)48种SW480候选上层基因的清单，其被选择用于确证表达 (通过SW480和DAC处理的SW480细胞的RT-PCR)和启动子甲基化(通过 SW480和DAC处理的SW480细胞的RT-PCR)状况。在图的左边指出了基因名 称，基因名称在PCR结果后面显示。水(RT-PCR)、体外甲基化DNA(MSP的 IVD)和肌动蛋白B(ACTB)用作每一单个基因的对照；显示了代表性的样品。 绿色箭头鉴定验证了阵列结果的基因，红色箭头鉴定那些没有验证阵列结果的基 因，如文中所论述地。
[30]图8.(表S1.)过度甲基化组大小的定量估计。细胞系和层在左边指出， 和每层中鉴定的基因表达变化的数量也被示出。关于每层候选过度甲基化基因库 的大小的计算通过每层鉴定的基因表达变化乘以0.86(HCT116的上层)、0.65 (SW480、CaCO2、HT29、COLO320和RKO的上层)或者0.49(HCT116、SW480、 CaCO2、HT29、COLO320和RKO下层)来进行。这些分数代表了实验所确定的 确认频率，如在本文所描述的。HCT116过度甲基化组大小的估计源于如下：532 的86％＝457上层基因加上1190的49％＝583下层基因；457+583＝1040。依照如下 计算，SW480过度甲基化组估计在579个基因：318上层的66％＝207和759下层 的49％＝372；207+372＝579。过度甲基化组基因清单和在乳腺癌或者结肠癌中突变 的基因之间的重叠在右边显示。
[31]图9.(表1)关于在序列表中的序列的信息。基因编号：基因流水号。 基因名称：在专利中使用的基因名称。基因ID：NCBI系统的基因ID。与基因ID 相关的转录物ID：来自ENSEMBL注释系统的所有转录物IDs，与具有相同TSS[转 录起始位置；注意，基因ID可以具有多个TSS，因而多转录物IDs通过它们的TSS 来分组]的特定基因ID相关。SEQ ID NO：1-125：基因组序列前后序列(从转录物 TSS的5′1000bp，到转录物TSS 3′的200bp)；如在NCBI build 36中发现的基因 组DNA序列。SEQ ID NO：126-250：亚硫酸氢盐转化形式的序列，假设所有CpG 二核苷酸的全甲基化存在。
[32]图10-截止比(ratio cut-off)20的散射图BNIP3。
[33]图11-截止比20的散射图FOXE1。
[34]图12-截止比100的散射图SYNE1。
[35]图13-截止比300的散射图SOX17。
[36]图14-截止比20的散射图JAM3。
[37]图15-截止比150的散射图MMP2。说明：这个标记在76个对照和90 个病例中进行了测试。
[38]图16-截止比150的散射图GPNMB。说明：这个标记在76个对照和90 个病例中进行了测试。
发明详述
[39]我们描述了人类全转录物组微阵列筛查来鉴定在人类CRC中被启动子过 度甲基化所沉默的基因。这种方法容易以高的证实效率在单个肿瘤中鉴定候选癌 基因。通过比较一系列候选过度甲基化基因与最近在CRC(3)中鉴定的突变基因， 我们建立了改变的肿瘤基因组和基因过度甲基化组之间关键的关系。我们的研究 提供了理解表观和遗传的改变如何促使人肿瘤发生的平台。
[40]我们描述了基因表达方法，对于可获得代表性细胞培养系的任何人类癌 症类型，该方法具有确定大部分癌基因启动子CpG岛DNA过度甲基化组的能力。 对这些基因的研究将有助于理解促使肿瘤发生的分子通路、提供有用的新DNA过 度甲基化生物标记来监测癌症风险评估、早期诊断和预后，并且允许在癌症预防 和/或治疗策略期间更好地监测基因再表达(13，22)。
[41]通过由我们方法发现的过度甲基化组基因与由基因组广泛测序策略 (genome wide sequencing strategy)鉴定的突变基因的直接比较，我们证明了在任 何特定的肿瘤中存在比遗传变化基因多许多的外遗传(表观)变化基因。这个事实的 重要性在我们的发现中显现：对于受两种机制影响的新发现的基因，在结肠癌中 任何特定基因的过度甲基化的发生率显得比突变高得多。因此，在特定的癌类型 中，由于未能筛查遗传和表观遗传异常，本领域技术人员可能明显地低估全范围 的基因改变和相关的细胞通路异常。数据也指出，比单独遗传分析所预测的，评 估基因功能丧失的两种机制对于通路中断在个体结肠肿瘤中显示出更多的共性 (sharing)。我们的发现强调，依照在关键通路中的分子改变对肿瘤分类的最佳方法 应该依赖于确定遗传和表观基因变化。因此，我们的发现应该促进在癌症中绘制 异常基因变化的任何基因广泛策略，从而考虑：应该检查突变基因的启动子DNA 过度甲基化和DNA过度甲基化基因应该放在进行测序以发现突变的优先位置。
[42]使用这种技术，我们已经发现了一组基因，它们的转录在癌、癌前体和 初癌中被外遗传沉默。这些基因包括：BOLL、CABYR、EFEMP1、FBLN2、FOXL2、 GNB4、GSTM3、HoxD1、Jph3、神经化的(NEURL)、PPP1R14a、TP53AP1、 RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、 LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、 FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、 TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、 FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、 RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、 MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3 和ZNF655。检测到这些基因的至少1、2、3、4、5、6、7、8、9或10个的外遗 传沉默可以用作癌或者初癌或者发展癌的风险的指示。
[43]基因的外遗传沉默可以通过在本领域中任何已知的方法确定。一种方法 是确定在正常细胞或者其它对照细胞中表达的基因在肿瘤细胞中较少表达或者不 表达。然而这种方法本身不能够指出沉默是外遗传性的，因为沉默的机制可能是 遗传的，例如通过体细胞突变。一种确定沉默是外遗传的方法是用试剂如DAC(5′- 去氮杂胞苷)(5′-deazacytidine)或者用改变细胞DNA的组蛋白乙酰化状况的试 剂来处理，或者影响在细胞中的外遗传机制的任何其它处理，并且观察沉默被逆 转，也就是基因的表达被再激活或者恢复。另一种确定外遗传沉默的方法是确定 在沉默基因中甲基化的CpG二核苷酸基序的存在。典型地，这些存在于转录起始 位置的附近，例如在大约1kbp之内、大约在750bp之内或者大约在500bp之内。 一旦基因被鉴定为在肿瘤细胞中外遗传沉默的靶标，减少表达的确定可以用作外 遗传沉默的指示物。
[44]基因的表达可以使用本领域已知的任何方法来评估。典型地，表达可以 在试样和对照样品中评估和比较，对照样品是正常的、非恶性的细胞。试样可以 含有癌细胞或者初癌细胞或者来自它们的核酸。例如，样品可以含有结肠腺瘤细 胞、结肠晚期腺瘤细胞或者结肠癌细胞。mRNA(核酸)或者蛋白可以被测量。可 以使用应用与核酸探针杂交的方法测量具体的mRNAs。这些方法包括使用核酸探 针阵列(微阵列技术)、原位杂交和使用Northern印迹。信使RNA也可以使用扩 增技术如RT-PCR来评估。基因组技术中的进步现在允许同时分析数千个基因， 虽然许多是根据特定探针-靶标杂交的相同概念。测序为基础的方法是可选的；这 些方法开始时使用表达的序列标签(EST)，并且现在包括基于短标签的方法，例 如基因表达系列分析(SAGE)和大规模平行特征测序(MPSS)。差别显示技术 提供了分析基因表达的另外方法；这类技术基于由限制性消化产生的cDNA片段 的随机扩增，以及在两种组织之间不同的带鉴定感兴趣的cDNA。特定的蛋白可以 使用任何常规方法来评估，包括但不限于免疫测定和免疫细胞化学术。大部分这 些方法将使用对特定的蛋白或者蛋白片段特异的抗体。本发明的标记的mRNA (cDNA)和蛋白的序列在本领域是已知的和可以公开得到的。
[45]甲基化敏感的限制性内切核酸酶可以用于检测甲基化的CpG二核苷酸 基序。这种核酸内切酶可以相对于非甲基化识别位点而优先剪切甲基化识别位点， 或者相对于甲基化识别位点而优先剪切非甲基化的识别位点。前者的例子是Ace III、Ban I、BstN I、Msp I和Xma I。后者的例子是Ace II、Ava I、BssH II、BstU I、 Hpa II和Not I。可选地，可以使用选择性地修饰甲基化的或者非甲基化形式的CpG 二核苷酸基序的化学试剂。
[46]修饰产物可以直接检测或者在产生容易辨别的产物的进一步反应之后进 行检测。检测改变的大小和/或电荷的方法可以用于检测修饰的产物，方法包括但 不限于电泳、色谱和质谱。这种选择性修饰的化学试剂例子包括肼和亚硫酸氢盐 离子。肼修饰的DNA可以使用哌啶处理来剪切它。亚硫酸氢盐离子处理的DNA 可以用碱来处理。其它依赖特定序列的方法也可以使用，包括但不限于杂交、扩 增、测序和连接酶链反应。如果期望，可以使用这些技术的组合。
[47]电泳的原理是通过它们的大小和电荷来分离核酸。存在用于检测甲基化 的许多测定方法，并且大部分依赖于确定特定核酸产物的有无。在实验室中为了 此目的经常使用凝胶电泳。
[48]本领域技术人员可以使用MALDI质谱结合甲基化检测分析来观察核酸 产物的大小。质谱的原理是对核酸进行离子化和依照它们的质荷比来分离它们。 类似于电泳，本领域技术人员可以使用质谱来检测在实验中产生的特定核酸以确 定甲基化。参见Tost，J.等，Analysis and accurate quantification of CpG methylation by MALDI mass spectrometry.Nuc Acid Res，2003，31，9。
[49]一种形式的色谱，高效液相色谱用于根据被分析物质与色谱柱之间的各 种化学相互作用来分离混合物的成分。DNA首先用亚硫酸氢钠来处理，其将未甲 基化的胞嘧啶转化成为尿嘧啶，而甲基化的胞嘧啶残基保持不受影响。本领域技 术人员可以经过PCR扩增含有潜在甲基化位置的区域和通过变性高效液相色谱 (DHPLC)来分离产物。DHPLC具有区别甲基化的(含有胞嘧啶)和没有甲基化 的(含有尿嘧啶)DNA序列的分辨能力。参见Deng，D.等，Simultaneous detection of CpG methylation and single nucleotide polymorphism by denaturing high performance liquid chromatography.2002Nuc Acid Res，30，3。
[50]杂交是根据两条互补核酸链的退火形成双链分子来检测特定核酸序列的 技术。杂交使用的一个例子是用于确定DNA甲基化状况的微阵列分析。在亚硫酸 氢钠处理DNA之后——其将未甲基化的胞嘧啶转变成为尿嘧啶，而甲基化的胞嘧 啶残基保持不受影响，与潜在甲基化位点互补的寡核苷酸可以与亚硫酸氢盐处理 的DNA杂交。寡核苷酸被设计成与含有尿嘧啶的序列或者含有胞嘧啶的序列互补， 其分别代表了未甲基化的和甲基化的DNA。以计算机为基础的微阵列技术可以确 定哪个寡核苷酸与DNA序列杂交，并且本领域技术人员可以推断DNA的甲基化 状况。
[51]确定在亚硫酸氢钠处理后结果的另外的方法将会是对DNA测序，以直接 观察任何亚硫酸盐的修饰。焦磷酸测序(Pyrosequecing)技术是通过合成测序的实时 方法。它基于焦磷酸盐(PPi)的间接生物光度计分析(bioluminometric assay)， 焦磷酸盐(PPi)是当DNA链延伸时从每个脱氧核苷酸(dNTP)中释放。这种方 法在核酸外切酶缺陷的Klenow DNA聚合酶存在的情况下呈现带有dNTP的DNA 模板-引物复合体。四种核苷酸以预先确定的顺序依次加到反应混合物中。如果核 苷酸与模板碱基互补并因而被加入，那么PPi被释放。PPi和其它试剂用作在荧光 素酶反应中的底物，荧光素酶反应产生通过光度计或者电荷耦合装置检测的可见 光。产生的光与加到DNA引物的核苷酸数量成比例，并且产生以热解图的形式存 在的指示核苷酸数量和类型的峰。焦磷酸测序可以利用在DNA的亚硫酸氢钠转化 后产生的序列差异。
[52]各种扩增技术可以在产生可辨别产物的反应中使用。这些技术的一些利用 PCR。其它合适的扩增方法包括连接酶链反应(LCR)(Barringer等，1990)、转 录扩增(Kwoh等.1989；WO88/10315)、目标多核苷酸序列的选择性扩增(美国 专利6,410,276)、共有序列引发的聚合酶链反应(美国专利4,437,975)、随机引 发的聚合酶链反应(WO90/06995)、核酸序列依赖性扩增(NASBA)(美国专利 5,409,818；5,554,517；6,063,603)、切口置换扩增(nick displacement amplification) (WO2004/067726)。
[53]反映原始基因组DNA中CpG二核苷酸处的甲基化状况的序列变化提供 了PCR引物设计的两种方法。在第一种方法中，引物自身不“覆盖”任何潜在的DNA 甲基化位点或者不与任何潜在的DNA甲基化位点杂交；在不同甲基化的位点处的 序列变化位于两引物之间。这种引物被用在亚硫酸氢盐基因组测序、COBRA、 Ms-SNuPE中。在第二种方法中，引物设计为特异地与甲基化的或者未甲基化形式 的转化序列退火。如果与靶标具有足够的互补性区域，例如12、15、18或20个 核苷酸，那么引物也可以含有另外的不干扰杂交、但对于其它操作有用的核苷酸 残基。这种其它残基的例子可以是限制性内切核酸酶剪切、配体结合或者因子结 合或连接体或重复序列的位点。寡核苷酸引物可以是或者可以不是这种对修饰的 甲基化残基特异的。
[54]区别修饰和未修饰的DNA的一种方式是杂交寡核苷酸引物，该寡核苷酸 引物特异地结合到DNA的一种形式或者另一种形式。在杂交后，可以进行扩增反 应和测定扩增产物。扩增产物的存在表明与引物杂交的样品。引物的特异性表明 DNA是否已经被修饰或未被修饰，其转而表明DNA是否已经被甲基化或未甲基 化。例如，亚硫酸氢盐离子修饰非甲基化的胞嘧啶碱基，将它们变为尿嘧啶碱基。 在杂交条件下，尿嘧啶碱基与腺嘌呤碱基杂交。因此，包含替代鸟嘌呤碱基的腺 嘌呤碱基的寡核苷酸引物会与亚硫酸氢盐修饰的DNA杂交，而含有鸟嘌呤碱基的 寡核苷酸引物会与DNA中未修饰的(甲基化的)胞嘧啶残基杂交。使用DNA聚 合酶和第二引物的扩增产生能够容易被观察到的扩增产物。这种方法被称为MSP (甲基化特异性PCR；专利5,786,146；6,017,704；6,200,756)。扩增产物可以任 选地杂交特异的寡核苷酸探针，而特异的寡核苷酸探针对某些产物也可以是特异 的。可选地，可以使用将与来自修饰和未修饰DNA的扩增产物杂交的寡核苷酸探 针。
[55]区别修饰和未修饰的DNA的另一种方式是使用对于某些产物也可以是 特异的寡核苷酸探针。这类探针可以直接与修饰的DNA或者修饰的DNA的扩增 产物杂交。可以使用本领域已知的任何检测系统来标记寡核苷酸探针。这些包括 但不限于荧光部分、放射性同位素标记的部分、生物发光部分、发冷光的部分、 化学发光的部分、酶、底物、受体或者配体。
[56]鉴定甲基化的CpG二核苷酸的还有另外一种方式是利用McCP2蛋白的 MBD结构域选择性地结合到甲基化DNA序列的能力(Cross等，1994；Shiraishi 等，1999)。限制性内切核酸酶消化的基因组DNA被加载在表达的His标记的甲 基CPG结合结构域上，CPG结合结构域被固定到固体基质和用于制备型柱层析来 分离高度甲基化的DNA序列。
[57]实时化学术使得能在反应的早期阶段期间检测PCR扩增，和使得DNA 和RNA的定量更容易和更准确。实时PCR的少数变化是已知的。它们包括 TaqManTM系统和Molecular Beacon(分子信标)TM系统，它们具有分开的用荧光团和 荧光淬灭剂标记的探针。在ScorpionTM系统中，发夹结构形式的标记的探针被连接 到引物。
[58]用许多技术已经成功进行了DNA甲基化分析，其包括MALDI-TOFF、 MassARRAY、MethyLight、乙基化等位基因的定量分析(QAMA)、酶区域甲基 化测定(ERMA)、HeavyMethyl、QBSUPT、MS-SNuPE、MethylQuant、定量PCR 测序和寡核苷酸为基础的微阵列系统。
[59]其沉默被测试和/或检测的基因数量可以变化：一、二、三、四、五或者 更多种基因可以被测试和/或检测。在一些情况下，选择至少两种基因。在另外的 实施方式中，选择至少三种基因。
[60]可以进行诊断性测试或者结合治疗方案进行测试。测试可以用于监测治 疗方案的效力，无论是化学治疗剂或者生物试剂如多核苷酸。测试也可以用于确 定什么样的治疗或者预防方案应用到患者上。而且，测试也可以用于把患者分成 几组用于测试试剂和确定它们在各组患者上的效力。
[61]用于诊断、预后或者个体化医学用途的测试样品可以从以下获得：外科 手术样品如活组织检查或者细针抽出液，石蜡包埋结肠、直肠、小肠、胃、食管、 骨髓、乳腺、卵巢、前列腺、肾、肺、脑等器官组织，体液如血液、血清、淋巴、 脑脊液、唾液、痰、支气管灌洗液、导管流体粪便、尿液、淋巴结或精液。这些 来源不是意欲穷尽性的，而是示例性的。从这些样品或者流体中获得的测试样品 包括分离的肿瘤细胞和/或从死亡或者损伤肿瘤细胞中释放的游离核酸。核酸包括 RNA、基因组DNA、线粒体DNA、单或双链和蛋白结合的核酸。从这种样品细 胞获得的纯化或未纯化形式的任何核酸样品可以用作起始核酸(一种或多种)。
[62]脱甲基剂可以与细胞在体外或者体内接触，目的是恢复细胞的正常基因 表达。合适的脱甲基剂包括但不限于5-氮杂-2′-脱氧胞苷、5-氮杂-胞苷、泽布拉恩 (Zebularine)、普鲁卡因和L-乙硫氨酸。这个反应可以用于诊断、用于确定倾向 和用于确定合适的治疗方案。如果脱甲基剂用于治疗结肠癌、头颈癌、食管癌、 胃癌、胰腺癌或肝癌，可以测试基因的表达或者甲基化，所述基因选自：BOLL、 CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化 (NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、 EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、 CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、 SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、 ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、 MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、 CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、 TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。
[63]恢复外遗传性沉默的基因表达的可选方式是将非甲基化的多核苷酸引入 细胞，这样它将在细胞中表达。各种基因治疗载体和媒介物在本领域中是已知的 和任何一种可使用的适合于特定的情况。某些载体适合于短期表达，而某些载体 适合于长时间表达。某些载体对于某些器官是有关营养的并且这些载体可以在特 定情况下适当使用。载体可以是病毒的或者非病毒的。多核苷酸可以但不是必要 的包含在载体例如病毒载体中，并且其可以配制在例如基质中，如脂质体、微泡。 通过将多核苷酸给予对象使得其接触细胞并被细胞吸收，多核苷酸可以被引入细 胞，并且编码的多肽被表达。优选地，特定多核苷酸将是患者已经被对其测试和 被发现携带沉默形式的多核苷酸。用于治疗结肠癌、头颈癌、食管癌、胃癌、胰 腺癌、肝癌的多核苷酸将典型地编码选自以下的基因：BOLL、CABYR、EFEMP1、 FBLN2、F0XL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、 TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、 CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、 DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、 SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、 EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、 PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、 CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、 ZNF345、DKK3和ZNF655。
[64]通过将脱甲基剂给予对象，将通常显示出甲基化沉默基因表达的细胞与 与脱甲基剂体内接触。如果方便，可以使用例如导管插入术方法给予脱甲基剂， 给予的地方在对象中显示不受调节生长的细胞的位置或者附近，或者给予进入到 血流到细胞位置的血管中。类似地，如果待被处理的器官或者其部分可以通过分 路方法被分离，试剂可以通过分路给予，因而实质上将试剂提供到含有细胞的位 置。试剂也可以全身给予或者通过本领域已知的其它途径给予。
[65]除了多肽编码序列外，多核苷酸可以包括可操作地连接的转录调控元 件、翻译调控元件等，和多核苷酸可以是裸露DNA分子的形式，其可以包含在载 体中或者其可以配制在基质如脂质体或微泡中，这帮助多核苷酸进入特定的细胞 中。术语“可操作地连接的(operatively linked)”指的是两个或者多个相互放置 的分子，这样它们作为单一的单元起作用和实现可归因于一个或者两个分子或者 其组合的功能。编码期望多肽的多核苷酸序列可以可操作地连接到调控元件，在 这种情况下，调控元件以类似于这样的方式在多核苷酸上赋予它的调控作用，在 该方式中，调控元件会影响在细胞中其与之正常联系的多核苷酸序列。
[66]编码待被给予哺乳动物或者人或待与细胞接触的期望多肽的多核苷酸可 以含有启动子序列——启动子序列可以提供多核苷酸的组成型，或者如果期望， 诱导型或者组织特异性或者发育阶段特异性表达、多聚腺苷酸(polyA)识别序列 和核糖体识别位点或者内部核糖体进入位点或者其它调控元件如增强子，其可以 是组织特异的。载体也可以含有在原核或者真核宿主系统或两者中复制所需要的 元件，如所期望的。这种载体——包括质粒载体和病毒载体如噬菌体、杆状病毒、 逆转录病毒、慢病毒、腺病毒、牛痘病毒、塞姆利基森林病毒(semliki forest virus) 和腺病相关病毒载体——是众所周知的和可以从商业来源购买(Promega，Madison WL；Stratagene，La Jolla CA.；GIBCO/BRL，Gaithersburg MD.)或者可以由本领域 技术人员来构建(参见例如Meth.Enzymol.，Vol.185，Goeddel，ed.(Academic Press， Inc.，1990)；Jolly，Cane.Gene.Ther.1：51-64，1994；Flotte，J.Bioenerg.Biomemb. 25：37-42，1993；Kirshenbaum等.，J.Clin.Invest.92：381-387，1993；它们中的每一个 在此引入作为参考)。
[67]四环素(tet)诱导型启动子可以用于促使编码期望多肽的多核苷酸的表 达。当将四环素或者四环素类似物给予含有可操作地连接到tet诱导型启动子的多 核苷酸的对象时，编码多肽的表达被诱导。多核苷酸可选地可以被可操作地连接 到组织特异性调控元件，例如肝细胞特异性调控元件如α胎蛋白启动子(Kanai等.， Cancer Res.57：461-465，1997；He等.，J.Exp.Clin.Cancer Res.19：183-187，2000)或 者白蛋白启动子(Power等.，Biochem.Biophys.Res.Comm.203：1447-1456，1994； Kuriyama等.，Int.J.Cancer 71：470-475，1997)；肌细胞特异性调控元件如肌红蛋 白启动子(Devlin等.，J.Biol.Chem.264：13896-13901，1989；Yan等.，J.Biol.Chem. 276：17361-17366，2001)；前列腺细胞特异性调控元件如PSA启动子(Schuur等.， J.Biol.Chem.271：7043-7051，1996；Latham等.，Cancer Res.60：334-341，2000)； 胰腺细胞特异性调控元件如弹性蛋白酶启动子(Ornitz等.，Nature 313：600-602， 1985；Swift等.，Genes Devel.3：687-696，1989)；白细胞特异性调控元件如增白细 胞蛋白(leukosialin)(CD43)启动子(Shelley等.，Biochem.J.270：569-576，1990； Kudo和Fukuda，J.Biol.Chem.270：13298-13302，1995)等，这样多肽的表达限制于 个体中的特定细胞或者限制于在培养中，例如在器官培养中的混合细胞群中的特 定细胞。包括组织特异性调控元件在内的调控元件在本领域中是众所周知的(参 见例如InvivoGen；San Diego Calif.)，许多组织特异性调控元件是商业可获得的。
[68]病毒表达载体可以用于将多核苷酸引入细胞中，特别是受试者的细胞中。 病毒载体提供了它们能够以相对高的效率感染宿主细胞和能够感染特定细胞类型 的优势。例如，编码期望多肽的多核苷酸可以被克隆进入杆状病毒载体，其随后 可以用于感染昆虫宿主细胞，由此提供了产生大量的编码多肽的方法。病毒载体 已被开发用在特定宿主系统，特别是哺乳动物系统中，病毒载体包括例如逆转录 病毒载体、其它慢病毒载，如那些基于人类免疫缺陷病毒(HIV)的载体、腺病毒 载体、腺相关病毒载体、疱疹病毒载体、肝炎病毒载体、牛痘病毒载体等(参见 Miller和Rosman，BioTechniques 7：980-990，1992；Anderson等.，Nature 392：25-30 Suppl.，1998；Verma和Somia，Nature 389：239-242，1997；Wilson，New Engl.J.Med. 334：1185-1187(1996)，它们中的每一篇在此引入作为参考)。
[69]多核苷酸——其可以任选地包含在载体中——可以通过在本领域中已知 的各种方法中的任一种被引入细胞(Sambrook等.，supra，1989；Ausubel等.，Current Protocols in Molecular Biology，John Wiley and Sons，Baltimore，Md.(1987和 supplements through 1995)，它们中的每一篇在此引入作为参考)。这些方法包括 例如转染、脂转染、显微注射、电穿孔和用病毒载体进行的感染；和可以包括应 用脂质体、微乳液等，脂质体、微乳液等可以帮助将多核苷酸引入细胞和可以保 护多核苷酸在引入细胞之前免于降解。特别有用的方法包括使多核苷酸并入微泡， 微泡可以注射入循环中。可以放置超声源，这样超声被传送给肿瘤，其中由于超 声，含有多核苷酸的循环微泡在肿瘤位置被破裂，因此在癌症的位置提供多核苷 酸。特定方法的选择将依赖于例如多核苷酸被引入的细胞以及细胞是否在培养中 或在体内原位位置。
[70]通过用病毒载体感染而将多核苷酸引入细胞可以有效地将核酸分子引 入细胞。而且，病毒是非常特异的，并可以根据在一种或者几种特定细胞类型中 的感染和繁殖的能力，来选择病毒作为载体。因此，它们天然的特异性可以用于 将包含在载体中的核酸分子靶向特定的细胞类型。基于HIV的载体可以用于感染 T细胞、基于腺病毒的载体可以用于例如感染呼吸道上皮细胞、基于疱疹病毒的载 体可以用于感染神经细胞等。其它载体，如腺相关病毒可以具有更大的宿主细胞 范围，因而可以用感染各种细胞类型，虽然病毒或者非病毒载体也可以用特定的 受体或者配体修饰，以通过受体介导的事件来改变靶标特异性。本发明的多核苷 酸或者含有多核苷酸的载体可以包含在细胞，例如宿主细胞中——宿主细胞使得 含有多核苷酸的载体得以繁殖，或者辅助细胞中——辅助细胞使得含有多核苷酸 的病毒载体得到包装。多核苷酸可以短暂地包含在细胞中，或者可以由于例如整 合进入细胞基因组中而被稳定维持。
[71]由基因(BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、 HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、 GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、 ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、 LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TF3、POMC、SOX17、 STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、 CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、 NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、 CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、 TSPYL6、ZNF345或ZNF655)编码的多肽可以直接给予到在受试者中显示出不受 调节的生长的细胞部位。如果期望的话，多肽可以使用本文公开的方法产生、分 离和配制，并且多肽可以与细胞接触，这样多肽可以穿过靶细胞的细胞膜。多肽 可以作为融合蛋白的一部分提供，融合蛋白包括有利于转运通过细胞膜的肽或者 多肽成分。例如，人类免疫缺陷病毒(HIV)TAT蛋白转导结构域或者核定位结 构域可以融合到感兴趣的标记。给予的多肽可以配制在基质中，基质帮助多肽进 入细胞。
[72]虽然在这里提到了特定多核苷酸和多肽序列作为已知基因和蛋白的代 表，但是本领域技术人员会理解，在数据库中的序列代表了在特定个体中存在的 序列。来自其它个体的任何等位基因序列也可以使用。这些典型地与公开的序列 变化1-10残基、1-5个残基或者1-3个残基。而且，等位基因序列与数据库序列典 型地具有至少95、96、97、98或者99％的同一性，同一性如使用运算法则如BLAST 同源性工具进行测量。
[73]试剂如脱甲基剂、多核苷酸或多肽典型地配制在适合给予受试者的组合 物中。因此，本发明提供了含有试剂的组合物，该试剂可用于恢复细胞受调节的 生长，该细胞由于一种或者多种基因的甲基化沉默转录而显示出不受调节的生长。 试剂作为治疗患有与这种不受调节生长相关的病理状况的受试者的药物是有用 的。这种药物通常包括载体。可接受的载体在本领域中是众所周知的和包括例如 水溶液诸如水或者生理缓冲盐水或者其它溶剂或者媒介物如乙二醇、丙三醇，油 如橄榄油或者可注射的有机酯。可接受的载体可以含有生理上可接受的化合物， 化合物起例如稳定或者增加结合物的吸收的作用。这种生理上可接受的化合物包 括例如糖类如葡萄糖、蔗糖或葡聚糖，抗氧化剂如抗坏血酸或谷胱甘肽，螯合剂、 低分子量蛋白或者其它稳定剂或者赋形剂。本领域技术人员会知道或者能够容易 地确定可接受载体，包括生理上可接受的化合物。载体的性质依赖于治疗剂的物 化性质和组合物的给药途径。治疗剂或者药物的给予可以通过口服途径或肠胃外 途径例如静脉内、肌内、皮下、经皮、鼻内、支气管内、阴道、直肠、瘤内途径 或者在本领域中已知的其它方法进行。药物组合物也可以含有一种或者多种另外 的治疗剂。
[74]治疗剂可以包含在封装材料里面，例如包含在水包油乳液、微乳液、胶 束、混合胶束、脂质体、微球体、微泡或者其它聚合物基质中(参见例如Gregoriadis， Liposome Technology，Vol.1(CRC Press，Boca Raton，FIa.1984)；Fraley，等.，Trends Biochem.Sci.，6：77(1981)，它们中的每一个在此引入作为参考)。例如由磷脂或 其它脂类组成的脂质体是无毒的、生理上可接受的可代谢载体，其制备和施用相 对简单。“隐形(Stealth)”脂质体(参见例如美国专利5,882,679；5,395,619； 和5,225,212，它们中的每一篇在此引入作为参考)是这种封装材料的例子，其对 于制备在本发明方法中有用的组合物特别有用，另外其它“掩蔽(masked)”脂 质体可以类似地使用，这种脂质体延长治疗剂停留在循环中的时间。例如阳离子 脂质体也可以用特定的受体或者配体进行修饰(Morishita等.，J.Clin.Invest.， 91：2580-2585(1993)，其在此引入作为参考)。另外，多核苷酸剂可以使用例如 腺病毒多聚赖氨酸DNA复合物引入细胞中(参见例如Michael等.，J.Biol.Chem. 268：6866-6869(1993)，其在此引入作为参考)。
[75]含有治疗剂的组合物的给药途径将部分依赖于分子的化学结构。多肽和 多核苷酸例如口服输送不是有效的，因为它们在消化道中可被降解。然而，例如 可以使用化学修饰多肽的方法，使它们更不易被内源性蛋白酶降解，或者使它们 更容易通过消化道吸收(参见例如Blondelle等.，supra，1995；Ecker和Crook，supra， 1995)。
[76]在实施本发明的方法中给予的试剂总量可以作为单剂量——或者作为大 丸剂或推注剂(弹丸，bolus)或者通过在相对短的时间段中输注——给予受试者， 或其可以使用分次治疗方案进行给予，在分次治疗方案中多剂量在长时间段中给 予。本领域技术人员会知道，在受试者中治疗病理症状的组合物的量依赖于多种 因素，包括受试者的年龄和总体健康以及给药途径和给予的治疗次数。考虑到这 些因素，本领域技术人员会根据需要调整具体的剂量。一般而言，最初使用I期和 II期临床试验来确定组合物的配方和给药的途径及频率。
[77]组合物可以配制用于口服制剂，例如片剂或者溶液或者悬浮液的形式； 或者组合物可以包含与适合于肠内或者非肠道应用的有机或者无机载体或者赋形 剂的混合物，和可以例如与常用、无毒、药学上可接受的载体化合，用于制备片 剂、丸剂、胶囊、栓剂、溶液、乳剂、悬浮剂或者其它适合应用的形式。除了在 以上所公开的那些载体外，载体可以包括葡萄糖、乳糖、甘露糖、阿拉伯胶、明 胶、甘露醇、淀粉糊、三硅酸镁、滑石、玉米淀粉、角蛋白、胶体二氧化硅、马 铃薯淀粉、尿素，中链长度甘油三酯、葡聚糖和适合用于制造固体、半固体或液 体形式的制备物的其它载体。另外，辅助剂、稳定剂、增稠剂或者着色剂和香料 也可以应用，例如稳定干燥试剂如丙酮糖(triulose)(参见例如美国专利5,314,695)。
[78]虽然通过使用标记的组合可以获得诊断和预后的准确性和灵敏性，例如5 或者6种标记、或者9或10种标记、或者14或15种标记的组合，但是实际考虑 可能决定使用更小的组合。特定癌症的标记的任何组合可以被使用，所述组合包 含2、3、4或5种标记。考虑到本文提供的单个标记的具体公开，可以容易地想 到2、3、4或5种标记的组合。
[79]差别甲基化GpG岛的甲基化水平可以提供关于疾病或者癌症的各种信 息。它可以用于在个体中诊断初癌或者癌症。初癌或者癌症前体是癌症的非常早 的阶段，它在结肠的最里(腔层)层中发现。它有时称为浅表癌(superficial cancer)。 可选地，它可以用于预测在个体中疾病或者癌症的过程，或者预测在个体中对疾 病或者癌症的易感性，或者对个体中疾病或者癌症的进展进行分级。它可以帮助 预测整体存活的可能性或预测疾病或癌症再次发生的可能性，并确定个体所经历 的疗程的有效性。当检测时，与参考水平相比的甲基化水平增加或者减少和增加/ 减少的改变提供了有用的预后和诊断价值。
[80]预后的方法可以用于鉴定可能发展为癌的腺瘤患者。这种预测可以根据 在腺瘤中相对于正常的组织在表1(图9)中所鉴定的至少一种基因的外遗传沉默 来进行。这些患者可以被提供另外合适的治疗或者预防选择，包括内镜息肉切除 术或者切除术，和当指出时，包括外科手术、化疗、放疗、生物反应调节剂或其 它疗法。这些患者也可以接受进一步诊断或者监测程序的建议，诊断或者监测程 序包括但不限于增加频率的结肠镜检查、乙状结肠镜检查、虚拟结肠镜检查、视 频囊内镜检查、PET-CT、分子成像或其它成像技术。
[81]治疗癌症患者的治疗策略可以根据外遗传沉默基因的再激活进行选择。首 先鉴定选自BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、 Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、 MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、 ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、 NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、 ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、 LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、 CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、 TRPC3、TSPYL6、ZNF345、DKK3和ZNF655的基因，所述基因在患者癌细胞中 的表达通过去甲基化试剂再激活或者外遗传沉默。随后选择增加基因表达的治疗。 这种治疗可以包括给予再激活剂或者多核苷酸。可选地可以给予多肽。
[82]依照本发明的试剂盒是用于测定甲基化的试剂的集合体。它们典型地在 含有所有成分的包装中，任选地包括说明书。包装可以分开，以便各成分不混合， 直到希望混合时。成分可以处于不同的物理状态。例如，一些成分可以是冻干的， 而一些在水溶液中。一些成分可以是冷冻的。在试剂盒内，单个的成分可以分开 包装。试剂盒可以含有如上描述的用于差异性修饰甲基化和非甲基化胞嘧啶残基 的试剂。理想地，试剂盒将含有寡核苷酸引物，该寡核苷酸引物与基因/标记的转 录起始位置的1kb内的区域特异性杂交，所述基因/标记为：BOLL、CABYR、 EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、 PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、 PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、 DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、 STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、 CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、 NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、 CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、 TSPYL6、ZNF345、DKK3和ZNF655。典型地，试剂盒将包含单个基因或者标记 的正向和反向引物。如果具有足够的互补区域，例如12、15、18或20个核苷酸， 那么引物也可以包含另外的核苷酸残基，这些核苷酸残基不干扰杂交，但是对其 它操作可能是有用的。这种其它残基的例子可以是限制性内切核酸酶剪切的位点， 用于配体结合或者用于因子结合或者连接体或者重复序列的位点。寡核苷酸引物 可以或者可以不对修饰的甲基化残基是特异的。试剂盒可任选地含有寡核苷酸探 针。探针可以对含有修饰的甲基画残基的序列或者对含有非甲基化残基的序列是 特异的。试剂盒可以任选地含有修饰甲基化胞嘧啶残基的试剂。试剂盒也可以含 有用于进行扩增的成分，例如DNA聚合酶和脱氧核糖核苷酸。检测工具也可以在 试剂盒中提供，包括在引物或者探针上的可检测的标记。试剂盒也可以含有用于 检测本发明的一种标记(表1；图9)的基因表达的试剂。这些试剂可以包括例如 探针、引物或者抗体。在酶或者配体的情况下，底物或者结合伴侣可以用于评估 标记的存在。
[83]在这个实施方式的一方面，基因与肼接触，肼修饰胞嘧啶残基，但是不 修饰甲基化的胞嘧啶残基，随后肼处理的基因序列与试剂如哌啶接触，该试剂在 肼修饰的胞嘧啶残基处剪切核酸分子，由此产生包含片段的产物。通过使用例如 电泳、色谱或者质谱的方法依照分子量分离片段，并比较该分离形式与类似处理 的相应非甲基化基因序列的分离形式，缺口在含有甲基化胞嘧啶残基的测试基因 中的位置上是明显的。因此，缺口的存在指示了在测试细胞的靶基因的CpG二核 苷酸中胞嘧啶残基的甲基化。
[84]亚硫酸氢盐离子例如亚硫酸氢钠将非甲基化的胞嘧啶残基转化为亚硫酸 氢盐修饰的胞嘧啶残基。亚硫酸氢盐离子处理的基因序列可以被暴露于碱性条件， 碱性条件将亚硫酸氢盐修饰的胞嘧啶残基转化为尿嘧啶残基。亚硫酸氢钠容易与 胞嘧啶的5，6-双键反应(但是与甲基化的胞嘧啶反应很差)形成磺酸化的胞嘧啶反 应中间产物，中间产物易于脱氨基，产生磺酸化的尿嘧啶。磺酸盐基团可以通过 暴露于碱性条件来除去，引起尿嘧啶的形成。DNA可以例如通过PCR扩增，并进 行测序来确定在样品的DNA中CpG位置是否被甲基化。尿嘧啶被Taq聚合酶识 别为胸腺嘧啶，而当PCR时，生成的产物仅在起始模板DNA中5-甲基胞嘧啶存 在的地方含有胞嘧啶。本领域技术人员可以比较在测试细胞的亚硫酸氢盐离子处 理的基因序列中尿嘧啶残基的量或者分布与类似处理的相应非甲基化基因序列中 的尿嘧啶残基的量或者分布。在测试细胞的基因中尿嘧啶残基的量或者分布的减 少表明在测试细胞基因的CpG二核苷酸中胞嘧啶残基的甲基化。尿嘧啶残基的量 或者分布也可以通过如下步骤检测：将亚硫酸氢盐离子处理的目标基因序列与寡 核苷酸接触、随后暴露于碱性条件并检测寡核苷酸的选择性的杂交(或者其不存 在)，所述寡核苷酸选择性地与目标基因的核苷酸序列杂交，该目标基因或者含 有尿嘧啶残基或者缺少尿嘧啶残基，但不是两者。
[85]测试化合物可以被测试它们治疗癌症的潜力。用于测试的癌细胞可以选 自前列腺癌、肺癌、乳腺癌和结肠癌。确定选自那些在表1(图9)中列出的基因 的表达，如果表达在细胞中被化合物增加，或者如果基因的甲基化在细胞中被化 合物减少，本领域技术人员可以鉴定该化合物具有作为治疗癌症的潜力。
[86]可选地，这些测试可以用于确定食管癌、头颈癌、胃癌、小肠癌、胰腺 癌、肝癌患者对化疗剂的反应。患者可以用化疗剂进行治疗。如果选自BOLL、 CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化 (NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、 EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、 CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、 SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、 ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、 MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、 CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、 TRPC3、TSPYL6、ZNF345、DKK3和ZNF655的基因的表达在癌细胞中被化合物 增加，或者如果基因的甲基化在癌细胞中被化合物减少，该化合物可以被选择用 于治疗患者。
[87]以上公开总体描述了本发明。所有在本文公开的参考文献通过引用明确 并入。更完整的理解可以通过参考以下具体的例子来获得，其在本文提供仅仅为 了举例说明的目的，而不是意欲限制本发明的范围。
实施例
实施例1
材料和方法
[88]细胞培养和处理。HCT116细胞和等基因遗传敲除衍生物如在以前描述 (14)地来维持。对于药物处理，对数期CRC细胞在McCoys 5A培养基(Invitrogen) 中培养96小时，McCoys 5A培养基含有10％BCS和1×青霉素/链霉素与5μM的 5氮杂-脱氧胞苷(DAC)(Sigma；储液：1mM，在PBS中)，每24小时更换培 养基和DAC。用300nM曲古柳菌素A(Sigma；储液：溶解在乙醇中的1.5mM) 处理细胞18小时。对照细胞平行进行模拟处理，加入没有药物的等体积PBS或者 乙醇。
[89]微阵列分析。依照制造商的指导——包括DNA酶消化步骤，使用Triazol (Invitrogen)和RNeasy试剂盒(Qiagen)从对数期细胞收获总RNA。使用NanoDrop ND-100，接着用2100Bioanalyzer(Agilent Technologies)进行质量评价，对RNA 定量。个体样品的RNA浓度大于200ng/ul、28s/18s比率大于2.2，和RNA完整值 为10(10为最高分)。使用低RNA输入荧光线性扩增试剂盒(Low RNA Input Fluorescent Linear Amplification Kit)(Agilent Technologies)，依照制造商的指导， 进行样品扩增和标记过程。标记的cRNA用RNeasy小型试剂盒(Qiagen)纯化和 定量。在扩增之前，RNA示踪对照(RNA spike-in control)(Agilent Technologies) 加入到RNA样品中。标记有Cy3或Cy5的0.75微克样品与对照靶标(Agilent Technologies)混合，依照Agilent微阵列方案聚集在寡微阵列(Oligo Microarray)上、 杂交和处理。用Agilent G2565BA微阵列扫描仪，使用Agilent Technologies推荐 的设置进行扫描。
[90]数据分析。所有阵列进行制造商所推荐的质量检查。视觉检查图像的假 象，检测信号的分布和红和绿两个通道的背景强度以鉴定异常的阵列。没有观察 到不规则，并且保留和使用所有阵列。使用R统计计算平台(23)和来自 Bioconductor生物信息软件项目(24)的程序包进行所有的计算。红信号与绿信号 的对数比在减去背景和LoEss归一化后进行计算，如在Bioconductor(25、26)的 半度软件包(limma package)中所执行地。单个阵列换算到有相同的四分位数 (inter-quartile)范围(第75个百分位数-第25个百分位数)。对于染色交换重复 (dye-swap replicate)微阵列，对数倍数变换进行平均，以产生每种条件的单一的 一组表达值。
[91]甲基化和基因表达分析。依照制造商的指导，用TRIzol试剂(Invitrogen) 分离RNA。对于反转录-PCR(RT-PCR)，1μg的总RNA通过使用Ready-To-GoTM You-Prime First-Strand Beads(Amersham Biosciences)进行反转录，加入随机六聚 体(每个反应0.2μg)。对于RT-引物设计，我们使用Primer3(http://frodo.wi.mit.edu/ cgi-bin/primer3/primer3_www.cgi)。对于MSP分析，依照标准的酚-氯仿提取方法 提取DNA。使用EZ DNA甲基化试剂盒(Zymo Research)进行基因组DNA的亚 硫酸氢盐修饰。使用MSPPrimer(http://www.mspprimer.org)，设计对未甲基化和 甲基化启动子序列特异的引物序列。MSP如以前描述(20)进行。所有PCR产物 (50μl总体积的15μl用于RT-PCR和25μl总体积的7.5μl用于MSP)直接加样在 含有GelStar Nucleic Acid Gel Stain(Cambrex Bio Science)的2％琼脂糖凝胶上， 并在紫外线照射下可视化。根据要求，用于MSP、亚硫酸氢盐测序和RT-PCR的 引物序列和条件可从作者得到。
[92]人肿瘤分析。来自原发性CRC的福尔马林固定的、石蜡包埋的组织从 Department of Pathology of the University Hospital Maastricht的档案库获得。获得了 马斯特里赫特大学(Maastricht University)、马斯特里赫特大学医院(University Hospital Maastricht)和美国约翰霍普金斯大学医院(Johns Hopkins University Hospital)的医学伦理委员会的批准。使用Puregene DNA分离试剂盒(Gentra Systems)分离DNA。
实施例2
[93]对于过度甲基化依赖基因表达变化的综合鉴定，我们的第一步通过在基 因组宽表达阵列为基础的方法中比较野生型HCT116CRC细胞与携带两种主要人 类DNA甲基转移酶的单独和组合的基因删除的等基因伴侣细胞来进行(图1A， 14)。重要地是，在DNMT1(-/-)DNMT3b(-/-)双敲除(DKO)HCT116细胞中—— 其实际上完全丧失了全部的5-甲基胞嘧啶，所有以前单个检查的过度甲基化基因 ——在野生型细胞中缺少基本表达——经受了伴随基因重新表达的启动子脱甲基 化(14-17)。通过依照在44K Agilent Technologies阵列平台上的改变的信号强度 将基因分级，当与等基因野生型亲代细胞或者等基因细胞系比较时，我们观察到 了在DKO细胞中基因表达增加的独特峰，在等基因野生型亲代细胞或者等基因细 胞系中DNMT的1或3b已经被个别地删除，其包含在DNA甲基化中最小的变化 (图1B)。
[94]根据我们以前的方法，我们使用药理学策略测试了我们的方法，但是现 在被明显地改良以提供全转录物组覆盖(19)，以鉴定在任何癌细胞系中沉默的 过度甲基化基因。对于致密的过度甲基化的和转录无活性的基因，DNA脱甲基剂 5-氮杂-2′-脱氧胞苷(DAC)具有充分确立的诱导基因重新表达的能力(18)。另 一方面，对于这些相同的基因，I和II类HDAC抑制剂曲古柳菌素A(TSA)将 不单独诱导重新表达(19)。在用DAC或者TSA处理HCT116细胞后(图1C)， 我们鉴定到这样的区域，在其中基因表达没有随着TSA增加(＜1.4倍)和在模拟 处理的细胞中没有显示可检测的表达。在这个区域内，我们观察到了DAC诱导的 基因表达的特征峰，其与在DKO细胞中所看见的基因表达增加相重叠(比较在图 1D中黄色点与在图1B中的蓝色点)。由于DAC整合入分裂细胞的DNA，而我 们的处理仅仅进行了96小时，与DKO细胞相比，在药理学方法中检测基因增加 的灵敏性被降低。这个基因峰的鉴定完全依赖于对没有对HDAC抑制作出反应的 唯一的基因进行分析，被簇分析加强，簇分析显示了在DKO和DAC处理细胞的 基因之间的亲密关系，在TSA单独处理后，DKO和DAC处理的细胞具有单独分 组的基因表达变化(图1E)。这些数据确认了覆盖很少基因组的先前研究，在其 中，带有致密CpG岛的被TSA再表达的基因没有包含可检测的甲基化(19)。基 因表达增加的类似峰可以在5种另外的人CRC细胞系(SW480、CaCO2、RKO、 HT29和COLO320)中看见，确认了这种方法在癌细胞系中普遍起作用(图2A)。
实施例3
[95]为了说明我们新阵列方法鉴定CpG岛过度甲基化基因的灵敏性，我们首 先检查了在HCT116细胞中11种已知被过度甲基化、完全沉默和在DAC处理后 重新表达的基因(图4(S1A))(14-17)。所有测试的基因保持在TSA未反应 区内(图4(S1B和C))，在DAC处理和DKO细胞中，表达变化的方向充分关 联(图4(S1D))。重要地是，对于DAC增加，5种指导基因(45％)增加2倍 或者2倍以上，以及另外3种基因或者总共73％的基因增加1.3倍或者1.3倍以上。
[96]根据在DKO与DAC诱导基因增加之间所观察到的灵敏性差异和指导基 因在阵列平台中的行为，在TSA阴性区域内，我们指定了基因的上层(2倍增加 或者以上)和下层(1.4倍至2倍之间的增加)来鉴定过度甲基化癌基因(图2B)。 我们也从这些区域中根据它们在未处理的细胞中没有基本表达来挑选基因。事实 上，在HCT116细胞中，总共532个基因的上层反应区中35个随机挑选的基因中 的30个基因(86％)，和来自318个上层基因的48个这样的SW480细胞基因的 31个基因(65％)证明被CpG过度甲基化——如通过MSP(20)所测量的，和在 来源的细胞系中被沉默——如通过RT-PCR测量的(图5、7(S2、S4)。我们也 检测了在DAC处理的HCT116细胞的下层中过度甲基化基因的发现效率。在这个 区域中的鉴定的1190个基因中，35个随机挑选的含有CpG岛的基因中的17个 (49％)被过度甲基化，具有一致的基因沉默(图6(S3))。这说明了与以前鉴 定新的癌过度甲基化基因的筛查相比(7、21)，我们的方法是特别有效的。以这 种证实的过度甲基化的水平，我们计算在HCT116细胞中过度甲基化组由估计的 1040个基因组成和对于SW480细胞由估计的579个基因组成(对于计算的详细描 述，参见图8(表S1))。过度甲基化组估计为从在CaCO2中的532个基因到 RKO细胞中的1389个基因的范围(图8(表S1))。在6个细胞系的所有层中鉴定 到总共5906个独特的基因，每个细胞系产生平均大约1000个过度甲基化组基因。
实施例4
[97]在细胞培养为基础的方法中根本的问题为是否它们鉴定了在原发性肿瘤 中作为失活靶标的基因。为了解决这个问题，来自证实的基因清单的含有CpG岛 的20个基因被从HCT116上层(17个基因)、HCT116下层(2个基因)或SW480 上层(1个基因)中随机选择，和分析在一组CRC细胞系中的甲基化。所有测试 的基因在2个或多个细胞系中被过度甲基化(图3A)。随后我们检测了在一组20 个到61个原发性结肠癌和20个到40个正常出现的结肠组织样品中的这20个基 因的状况，正常出现的结肠组织样品从无癌的个体中获得。在正常结肠组织样品 中，大部分基因(65％)完全没有被甲基化或者很少甲基化，但在绝大多数原发性 肿瘤中(86％)被甲基化(图3A)。分析的20个基因中，13个基因(65％)满足 在细胞系中具有高频率甲基化的“肿瘤特异性甲基化”的标准，在正常结肠中低的或 者未检测到的甲基化和在肿瘤样品中频繁的甲基化。我们策略的效率揭示在细胞 系中对于鉴定过度甲基化基因至少二分之一(1/2)的发现率，和对于鉴定癌症特异 性过度甲基化基因至少三分之一(1/3)的发现率。
实施例5
[98]虽然清楚的是，遗传和外遗传机制对人类肿瘤发生的起始和进展都是重 要的，但是对这些改变的每个的相对贡献了解不多。对少数癌基因甲基化和突变 频率之间的比较还没有令人信服地证明任一途径的普遍性。重要地是，还没有进 行全基因组分析来质疑这个问题。
[99]在最近的癌基因全基因组测序中，等(3)观察到突变一般而言 具有低的发生率，鉴定的90％的基因包含小于10％的突变频率。此外，典型的结 肠或者乳腺癌每个单个肿瘤仅含有平均11个突变，单个肿瘤之间具有很少的重叠。 这些低频率提出了这样的问题：是否可选的机制可能在另外的肿瘤中导致这些基 因的失活。显然，我们现在在个体肿瘤中鉴定到数量大得多的候选过度甲基化基 因(图2C)，这表示这种外遗传改变可能为许多肿瘤抑制基因的突变提供了可选 的失活途径。
[100]当我们搜索候选过度甲基化基因和189种突变癌(CAN)基因之间的 匹配时，筛查肿瘤的遗传和外遗传变化的重要性被显著加强。我们首先质疑我们 5906个过度甲基化组基因清单与在乳腺和CRC肿瘤中鉴定的CAN基因清单。这 鉴定了这56种共有基因，其中45种含有CpG岛。这些45种基因中的26种(58％) ——类似于如上所述鉴定的所有候选基因的证实率——证明在6个细胞系的至少1 个中被过度甲基化，并被选择用于进一步研究。重要地是，正好一半的基因(13 种基因)在正常结肠中未被甲基化，但是在原发性CRC肿瘤中被甲基化(图3B、 C)，给出了鉴定肿瘤特异性甲基化的50％的频率。对于事实上每种检查的基因， 过度甲基化的发生率显著高于突变的发生率(图3D)。因此，不同于突变的基因， 大多数基因的过度甲基化在许多肿瘤之间是共有的性质。在先前未表征的基因中 这些外遗传沉默和突变的发现巩固了它们作为肿瘤抑制基因的可能作用。(图3E)。
实施例6--收集的BNIP3、FOXE1、SYNE1、SOX17、JAM3、MMP2和GPNMB 的另外组织数据
材料和方法
用于组织确认的临床样品
[101]对应于77个正常组织和94个癌样品，总共171个结肠石蜡包埋的组织 样品使用实时MSP进行处理。表2给出了用于组织确认的样品组的概述。
表2-临床样品组的详细资料
石蜡包埋组织样品的DNA提取
[102]福尔马林固定的石蜡包埋样品首先在750μl的二甲苯中去除石蜡2小 时。然后，在以13000rpm离心15分钟之前，加入250μl的70％的乙醇。除去上 清液，并在室温下空气干燥样品20分钟。使用经典的酚/氯仿提取方法提取DNA， 并在50μl的LoTe(3mM TRIS，0.2mM EDTA，pH 8.0)中重悬浮。随后，使用 dsDNA定量试剂盒(Molecular Probes，Invitrogen)，依照制造商的推 荐对DNA定量。随试剂盒提供的λDNA用于制备标准曲线(从1到800ng/ml)。 使用FluoStar Galaxy平板读取器(BMG Lab technologies，德国)收集数据。
DNA修饰
[103]使用EZ-96DNA甲基化试剂盒(Zymo Research)，依照制造商的方案， 1μg的DNA在移液自动机(Tecan)上以96孔形式进行亚硫酸氢盐修饰。基本上， 等份的45μl与5μl的M-稀释缓冲液(M-Dilution Buffer)混合，并在37℃以1100rpm 摇动温育15分钟。接着加入100μl的稀释的CT转化试剂，样品在70℃、在黑暗 中以1100rpm摇动温育3小时。在转化后，通过在冰上温育10分钟进行和加入 400μl的M-结合缓冲液对样品脱盐。样品加样到收集盘中的Zymo-Spin I柱上，并 离心后，用200μl的M-洗涤缓冲液(M-Wash Buffer)洗涤。200μl的M-去磺化缓 冲液(M-Desulphonation Buffer)放置在柱上并在室温温育15分钟。在柱子离心后， 它们用200μl的M-洗涤缓冲液洗涤2次。最后，DNA在125μl Tris-HCl 1mM pH8.0 中从柱上洗脱和储存在-80℃，直到进一步的处理。
DNA扩增
[104]在7900HT快速实时PCR系统上(Applied Biosystems)应用实时MSP。 5μl修饰的DNA加到PCR混合物(总体积10μl)中，PCR混合物含有缓冲液(16.6 mM(NH4)2SO4、67mM Tris(pH 8.8)、6.7mM MgCl2、10mM β-巯基乙醇)、dNTPs (5mM)、正向引物(6ng)、反向引物(18ng)、分子信标(0.16μM)和Jumpstart DNA Taq聚合酶(0.4单位；Sigma Aldrich)。用于每个基因的引物序列和分子信标 序列总结在表3中。使用如下循环程序：5分钟95℃，接着45个30秒95℃、30 秒57℃和30秒72℃的循环。包括标准曲线(2×106-20拷贝)以通过内插它们的 Ct值到标准曲线来确定未知样品的拷贝数。
表3-引物序列和信标序列
在组织材料上的标记确认
[105]如以上所描述进行实验。使用在表3中详述的引物对和信标探针在组织 材料上确认结肠标记：BNIP3、FOXE1、SYNE1、SOX17、JAM3、MMP2和GPNMB。 另外，测量独立的参考β-肌动蛋白(ACTB)。使用SDS 2.2软件(Applied Biosystems) 产生结果并以Ct值(扩增曲线超过阈值的循环数量，由软件自动设定)输出。使 用标准曲线推算拷贝数。每个样品的感兴趣基因与ACTB的比率(乘以1000)用 作测量值，代表在每个样品内每个感兴趣基因的甲基化DNA的相对水平。
[106]在正常样品中(对照)和癌症(病例)中BNIP3、FOXE1、SYNE1、 SOX17、JAM3、MMP2和GPNMB的甲基化特异性PCR散射图在图10-16中显示。 测量值表示为甲基化比率，定义为与ACTB比较每个基因的荧光强度值的比率， 乘以1000，以便容易作表。
[107]如在图10-16中所指出，在调查的对照和病例组之间，观察到清楚的比 率差异。
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序列表
<110>S.拜林
<120>结肠癌的早期检测和预后
<130>006791.00012
<160>250
<170>FastSEQ for Windows Version 4.0
<210>1
<211>1200
<212>DNA
<213>智人(Homo sapiens)
<400>1
ccgcctcctc tccattttac agaggaggaa accgagggtt gagcggcgaa tgatttgccc 60
tgcctgccca gcacggaaaa aaatcactct tctggcccca gtcgcctccc tttctgtgct 120
gtgagtctgt gtccagagca ggaagggctg ctccgagctg cagggacggg ctctgtgtgt 180
taaaccttca aatggcttcc agggactcat ggagcatcca ggacacctgg agatggcgac 240
tcctgggacc cctggccctt ccctcctctg gccttcggtc cgtgagggtg aattaagtgt 300
gccacccacc aggggcagag acacatggag acagagattg agagacagag aacagagggg 360
gagacagaaa gagagaggga catgaagagc aacggagtta caggaggatc tgacgctccg 420
ttggggagac agggagaaat gtggggagat gcagcgtccc aggtgctccc cagtggccct 480
gcccctcctc ccctctcccc tccccaccag gcaggaccct cagggagctc cagcctggac 540
ccgaaccctg tcccaccctg acgcacctgc accaggccag gctggacctg tggggtgggt 600
gcaggcctgg ccccagcccg gccactgccc tggaaacccc tcccccgcca agatgctgat 660
gtaacatcca ggatttgatg ttttactctc caattctgca aatccagacg caggaggttt 720
taagaggccg ttgcaccctg caataaagtg cgggacacag gaatcttggt cctcggggca 780
cccccttccc tcgggggggt ttcgcccccc gcactcacgg cccctgagcc cgcgcggagg 840
cccgacgccc cgcggccgac gccggtcccc gccccgggcc gccattggct gttgccatgg 900
caccagcccg tcttcccgcg ccctcattgg ctgtctcacc cgcatccctc atcccgcatc 960
ctcccccgct cgcggtggtc tcgcccagcg ctaggagcgg cagcgccgcc tgcccaggcc 1020
cggaccgggc tttgtccgcc ccggagcccc tgcccgcgcc gcggagaccc cggagcccgc 1080
gcgctccgag gccaccccgg gccgggattt ccggtggggc ccgcggagcc gcgcagaggg 1140
aggaggcccc agacccaggc gccccgccag cccagctgca cgtaagcggg tgtgtgtcct 1200
<210>2
<211>1200
<212>DNA
<213>智人
<400>2
aaaactgtca tggttacagc catcaaatta caggaggttc acacacagca gtcagcaatg 60
gtttgggaat attaaataaa tgtgtttctc taacaggaca agacaggatc atttatttat 120
gcaacttaaa agctgtccca gaaggagaaa aaagtagcgt attatttgtc caaaataaac 180
aagattgaag aactgaacat ctctctgtgg atcaatttac agatcacatg gaaataggct 240
tatcttattg agaaatattc cattttagat gttcaaatac cttagcatat tttaaaaact 300
atttcctatg tgaccaaaag aattcatgtt ctattcggta aaaattaacc aaaattaacg 360
gtgctttcca atggacgcag gaaacctttt ttctttacaa aatatgccca cccttttttt 420
gttgctactt cccacattga attcttgttt tactgaattt tcttactata aaaataaagc 480
atgatgatag ttttgaaaac aaaacagaag tatttgagaa gtacagaccc cactcccact 540
ccttgtctcc tttctgacac tctgcccctt aactatactg gaacagggag tcaactgcaa 600
ggaaaatcct ggggactagg ggctgaggaa ctagaggtgg agagatggaa gagtgtccag 660
tagcccagga aaggatgaaa caattcccca acaaaaaagt aaaaattttc agtagccctc 720
cgagaagatg cagcccctcc caggtaacca gagaaaggca aattgtgaaa gcagggagaa 780
ggggctactt taggcctcca ggactacaaa gacaaaaaaa tgagtgacag gacctgatgt 840
ggtggggtga gatgggaatg gaagtaaagg agggggctcg tactcttggt gggagtggaa 900
attggggacc caagcttact ggcgatgcag ccctcacgtg accaggagct gacgtgggca 960
aaggtactta aagccctgac cgtcgttctc cgtcctcctc tgggtaccaa ctctattgcg 1020
cagctcgctg ccgtgcgttt aacccaggcg aggaggagga ggagaaaatt cccccagatt 1080
cgggcaggtg ggtgtgaggg tgggcacagt ctgggacccc tgaatagggt aatctaggga 1140
tgcgggagtc ggaggccgcg ggtgcctcgg tctcccccac tcctggccgg ctttccagac 1200
<210>3
<211>1200
<212>DNA
<213>智人
<400>3
ccagacctga ggtgctcaaa cgcggctcat tttggtgggc ggtggggaaa gggggagggg 60
gaaacgaaaa gacttttgat agactttacg aagaatccgc ttacttcctt tccagccagt 120
gttttttggt tttgtttata atattcaggc ccgcacccca cattccgtcc tgttttgaga 180
ggaggaggga agagaaataa acgtggcagc gcatagaagg ccagcaggga ggttgggaaa 240
gggtaaccag gaggcggggg tggggcatgc aatttggtaa caatctgggc ggcacactcc 300
caccctgact ttccccacca ccgccccggc accctcccat cccccagccg accctctgtg 360
atttgggagt gctgggaaat gggtgtacca gctgctgttg gagaggtggc gggtttggcg 420
ctgtctgggc ttcacgggag gtggggggga aggggcggac cctgagagaa tctggtatta 480
aaccgccttg ttaactcgca gactgctttc cagacacctc cggcccacac agccgttcac 540
cccccgtctt ttcagtcctg gaaaaggaat tcgggtatgc aggcgggaga aatggcggtt 600
gttgggggga tttgtgggaa gtgggaggta gagcccatag cagagaaatc gtggaaaatc 660
tcgaccctga acccgaaaag gcagacgttg aggcccctct tctgcaggct aacgctaggc 720
ctaggggctg gggagcgaaa gatgggtgat cctgggaggg gaacactgaa ttgtttggca 780
ggagtccccc ataccgcgtc ccatccagct tttgctgcac cctcgccccg ctcccctccc 840
gcttcgttgc aggagaaggg gtgtggcggt gtgtcctgga gaaatggcgg acgggggcgg 900
ggcaaagcgg aaggagggat tgagtgcctg gggagcctgc gcaggaggag gattgaggtg 960
ggaggggtgg ggtgagaaga gttgaaggaa ttgagaggta gaatcatttg acattctgat 1020
gtgcaaacac gaaaaggcag ttactgagac ccttgtcctg gatgctgatc catccaccag 1080
gctttcattg tctaacgtcg acagtctata tttctgctct tcagtctgtc cttaggatga 1140
agctctaact gaactgaagt aaggagaaac agccttgaat ctttggaggg tcagtgctgg 1200
<210>4
<211>1200
<212>DNA
<213>智人
<400>4
cccagagttg aatcattaac tggaacctaa tccgaagaca ggtgtttaaa actgtcatgg 60
ttacagccat caaattacag gaggttcaca cacagcagtc agcaatggtt tgggaatatt 120
aaataaatgt gtttctctaa caggacaaga caggatcatt tatttatgca acttaaaagc 180
tgtcccagaa ggagaaaaaa gtagcgtatt atttgtccaa aataaacaag attgaagaac 240
tgaacatctc tctgtggatc aatttacaga tcacatggaa ataggcttat cttattgaga 300
aatattccat tttagatgtt caaatacctt agcatatttt aaaaactatt tcctatgtga 360
ccaaaagaat tcatgttcta ttcggtaaaa attaaccaaa attaacggtg ctttccaatg 420
gacgcaggaa accttttttc tttacaaaat atgcccaccc tttttttgtt gctacttccc 480
acattgaatt cttgttttac tgaattttct tactataaaa ataaagcatg atgatagttt 540
tgaaaacaaa acagaagtat ttgagaagta cagaccccac tcccactcct tgtctccttt 600
ctgacactct gccccttaac tatactggaa cagggagtca actgcaagga aaatcctggg 660
gactaggggc tgaggaacta gaggtggaga gatggaagag tgtccagtag cccaggaaag 720
gatgaaacaa ttccccaaca aaaaagtaaa aattttcagt agccctccga gaagatgcag 780
cccctcccag gtaaccagag aaaggcaaat tgtgaaagca gggagaaggg gctactttag 840
gcctccagga ctacaaagac aaaaaaatga gtgacaggac ctgatgtggt ggggtgagat 900
gggaatggaa gtaaaggagg gggctcgtac tcttggtggg agtggaaatt ggggacccaa 960
gcttactggc gatgcagccc tcacgtgacc aggagctgac gtgggcaaag gtacttaaag 1020
ccctgaccgt cgttctccgt cctcctctgg gtaccaactc tattgcgcag ctcgctgccg 1080
tgcgtttaac ccaggcgagg aggaggagga gaaaattccc ccagattcgg gcaggtgggt 1140
gtgagggtgg gcacagtctg ggacccctga atagggtaat ctagggatgc gggagtcgga 1200
<210>5
<211>1200
<212>DNA
<213>智人
<400>5
tgtttaaaac tgtcatggtt acagccatca aattacagga ggttcacaca cagcagtcag 60
caatggtttg ggaatattaa ataaatgtgt ttctctaaca ggacaagaca ggatcattta 120
tttatgcaac ttaaaagctg tcccagaagg agaaaaaagt agcgtattat ttgtccaaaa 180
taaacaagat tgaagaactg aacatctctc tgtggatcaa tttacagatc acatggaaat 240
aggcttatct tattgagaaa tattccattt tagatgttca aataccttag catattttaa 300
aaactatttc ctatgtgacc aaaagaattc atgttctatt cggtaaaaat taaccaaaat 360
taacggtgct ttccaatgga cgcaggaaac cttttttctt tacaaaatat gcccaccctt 420
tttttgttgc tacttcccac attgaattct tgttttactg aattttctta ctataaaaat 480
aaagcatgat gatagttttg aaaacaaaac agaagtattt gagaagtaca gaccccactc 540
ccactccttg tctcctttct gacactctgc cccttaacta tactggaaca gggagtcaac 600
tgcaaggaaa atcctgggga ctaggggctg aggaactaga ggtggagaga tggaagagtg 660
tccagtagcc caggaaagga tgaaacaatt ccccaacaaa aaagtaaaaa ttttcagtag 720
ccctccgaga agatgcagcc cctcccaggt aaccagagaa aggcaaattg tgaaagcagg 780
gagaaggggc tactttaggc ctccaggact acaaagacaa aaaaatgagt gacaggacct 840
gatgtggtgg ggtgagatgg gaatggaagt aaaggagggg gctcgtactc ttggtgggag 900
tggaaattgg ggacccaagc ttactggcga tgcagccctc acgtgaccag gagctgacgt 960
gggcaaaggt acttaaagcc ctgaccgtcg ttctccgtcc tcctctgggt accaactcta 1020
ttgcgcagct cgctgccgtg cgtttaaccc aggcgaggag gaggaggaga aaattccccc 1080
agattcgggc aggtgggtgt gagggtgggc acagtctggg acccctgaat agggtaatct 1140
agggatgcgg gagtcggagg ccgcgggtgc ctcggtctcc cccactcctg gccggctttc 1200
<210>6
<211>1200
<212>DNA
<213>智人
<400>6
ttacaggctt gagccaccat gcccggccaa gatgtcagtt ttttaatggt gtgcaacgtc 60
cgtttctttg atagttggaa agcgtggcag gtattagagg gcgaatgtat atttaagaaa 120
aacaagataa gtcttcatct gtagagtatt aatttttctg tgatccttta tctcagacgc 180
ctctcctctg aaggtcactg ctcaagctgg gcagcccctt ctaagaaggg atgctgcctt 240
ggagttggag atgaggttaa gatctacgtg cgggtaccag tttcagtaat aactggatcc 300
ttctctaggt ctaggctgga acgtctcaag tgaaggttat tggggggcag gggtttgggt 360
ccacccaaaa aggcttgacc cataggactg aaatcaaatc ttgagctagg ctggcttgcc 420
acgtaaccac agaaacagta atttaagcaa taaaatgaaa gctcgagcgc tggtccagag 480
ctggggttgg gacagctact gcactcaggt ctccaggtgc atgtagggag aagagcagcg 540
gatcccttgc agacaatggt gggagcgagc tcttcaccct ggggtctccg aagcccattt 600
ttagcgtcca gaggtgtgct ttcgccatct ccttctgcgg tggctgcttg cagggcgcat 660
tcccattgct gctgtctctg ttcctaagga agatcaaagg atcccagaaa acccagttcc 720
agagctcagt tcccgggact agagggtacg ctcggccaga tggctggggg tgccgctggc 780
cttggcgccc ccgccgtccc cgcgcggtcg cccaccccgg cccgacaagc agcttgggcg 840
tccagcccgg cccggtccct gcagggaggg agcgcaggag ctgggggcgg ctctcccggg 900
gcggggctcg ctccacaagc gccaggggcc gcgcggggcg tgggcgtggg cggggccggg 960
ggcggggccg gccttggctg ccgcggcaca ggcggcggcg tctccagggg gagccaaggt 1020
acgtaggcgg cgtccgcctc acccgagcat ccttccccgc cggtggccgc ccgcccgcgg 1080
cccgcgctcg cagcctcccg cctggcggtt gacttctttg tgtcgtattc tctgcctgcg 1140
ccctgtctct gcaggacctg ttcgttcttc tttgggctat aagaaggcag aggatgagat 1200
<210>7
<211>1200
<212>DNA
<213>智人
<400>7
ttctgtgatc ctttatctca gacgcctctc ctctgaaggt cactgctcaa gctgggcagc 60
cccttctaag aagggatgct gccttggagt tggagatgag gttaagatct acgtgcgggt 120
accagtttca gtaataactg gatccttctc taggtctagg ctggaacgtc tcaagtgaag 180
gttattgggg ggcaggggtt tgggtccacc caaaaaggct tgacccatag gactgaaatc 240
aaatcttgag ctaggctggc ttgccacgta accacagaaa cagtaattta agcaataaaa 300
tgaaagctcg agcgctggtc cagagctggg gttgggacag ctactgcact caggtctcca 360
ggtgcatgta gggagaagag cagcggatcc cttgcagaca atggtgggag cgagctcttc 420
accctggggt ctccgaagcc catttttagc gtccagaggt gtgctttcgc catctccttc 480
tgcggtggct gcttgcaggg cgcattccca ttgctgctgt ctctgttcct aaggaagatc 540
aaaggatccc agaaaaccca gttccagagc tcagttcccg ggactagagg gtacgctcgg 600
ccagatggct gggggtgccg ctggccttgg cgcccccgcc gtccccgcgc ggtcgcccac 660
cccggcccga caagcagctt gggcgtccag cccggcccgg tccctgcagg gagggagcgc 720
aggagctggg ggcggctctc ccggggcggg gctcgctcca caagcgccag gggccgcgcg 780
gggcgtgggc gtgggcgggg ccgggggcgg ggccggcctt ggctgccgcg gcacaggcgg 840
cggcgtctcc agggggagcc aaggtacgta ggcggcgtcc gcctcacccg agcatccttc 900
cccgccggtg gccgcccgcc cgcggcccgc gctcgcagcc tcccgcctgg cggttgactt 960
ctttgtgtcg tattctctgc ctgcgccctg tctctgcagg acctgttcgt tcttctttgg 1020
gctataagaa ggcagaggat gagatgtccc gggccacgtc tgttggagac cagctggagg 1080
cacccgcccg caccatttac ctcaaccaac cgcatctcaa caaattccgc gacaaccaga 1140
tcaggtagga gaaggcggcc ggctcgcgcg gaaggcggtg gagtcacagc tgggaagggg 1200
<210>8
<211>1200
<212>DNA
<213>智人
<400>8
ttgtcagtcc ctaatgttaa tttaggttaa aagaaatgta atgctcgcat cagtaaaagc 60
aaggtcagac tttcacctga acagttttat ttttgttttg ttccgttttt actccgaggt 120
cagaatgtca tcaggcacaa taaagatagc ttcttatctt catgggattg tgcccagaaa 180
gaccaagcac agtctaaaca ttacgcgata agaaaaaaca aaaaatagat caagtgacct 240
tggacaagtc atcttacctc tcgatggttt tgttttatga aagaaggtgt gtgtgtgtgt 300
gtgtcgatgg gtgtgtgtgt gtgtgtgtcg atgggtctgt gtgtgtgtgt gtgtgtgtcg 360
atgggtgtgt gtgtgtgtgt gtgtgcgtgc gggggttgag aaggttgctg ttaaggttcc 420
ctagggctac ctgcagcttt aatatgcgta gttagaatgt caggcaggtt gtggagagtg 480
gggggctgga gacccccgac ttctctgagt gccaagccac acatcagaca ccttggaaat 540
aacccttcca cgaagtccct acacagatcc caccaggctg ggcacggaag aacagaaact 600
gcgaaaagaa agggactgga tgagtcctgg ggaatcacag cgcctccact tgcacaggac 660
aagtgacagg caggtaaata ggtagcagac aggcagagac tccgagtccc ccaggtgcac 720
ccctctcctg gaagagcccc cgaaagtaca ggcccaatct cccaccccac caagccctcc 780
ccatcgcctt ccccgacacc taaaagcccc ggtcctgcgt aatattgcgg atccctccca 840
gcctcccgtc cgctcctcct cccgcggggc tccgctcagg gccggtcccc cgcccccacg 900
ccgcagcccg ggccagcggg gcccgccgcg gtggcgttcg cggatgctgc cgcattggcc 960
gctgcggcac ggacggcgca gcctcgggcg cggcccggca caggcgccgg cggtccccgc 1020
cagctagcag cccggcgagg cgctggccca cccatggtcc tcgggcggcg gcccctgcgc 1080
ccagccctgc gcgtagcctc cgtctctcgc ccggggccgc cgagcccccg acacgggcga 1140
gatgctgaac ggcgcaggcc tggacaaagc tcttaagatg tccctgccgc ggaggtcgag 1200
<210>9
<211>1200
<212>DNA
<213>智人
<400>9
gccaaagtga tatattaagg tcaccacctt ggtcacctgt ccatctatat ttttggagta 60
agcaacagaa ttaggagtct gaacatagga attaagaagc tctcgaatat aacagtggaa 120
gaccagcacc ttcccaacct cttgtcaggg cagggatact ctatctctgc gtcactcaac 180
ctgccttggc ctcacagctc ttccttttgc ttaagtcttc aaaccatcaa cagtgatagc 240
cactaatttt agcaggtggc attagttgtc agcaaatgtt ttttcatatt taatgaatgt 300
ttattataat agaataaaat agaaatgttt attaataaaa cttgaaattt gtcccagaag 360
gataaaaacg tagattattt acataaaatg gccaagatct gacaacagaa ctgtttcctg 420
aagatttact tcacagatta ttttgaaaac accaactgtg ttcaggaaaa ttttctctcc 480
tttttttcat aaaattttca aacaagtgag aatgctctaa aaatgatggt gtggagccta 540
gagaaaatgt tttctgtgtg ctatagatga acataaacta tatatatata ttactttccc 600
aggttgaagt gtttctttca aaaataaaat ttgattattt tcaatttttt gagggatgct 660
gatttttaaa aaggaaataa agagaaatta ttaggaagca tatacacagc cagtgagaag 720
aggaaagaag aaaaggccaa ggccagagga agggggtttg gggtggggga aaggaagggt 780
acagaccctc ccaaataacc gaagatgggt aaactccaac cgcaaagcga tgatgccact 840
tgtgggccct cagattggag aggacggaga tgagtgacgg ggctgtgcgc actggggcac 900
cgcgcacaga cgggaggagg ggggtgtctg tgtgttccaa aggggggagt accagttaac 960
tggccgccgg cccgtggggg ttggtgagaa ggagggtgag cttggcggtg acgcacggcc 1020
ctcacgtgac cgggagctgc agagctacgc agccttcggt gcagtcgtca ctcgtgtctc 1080
gctaccagct ccccgctgcc ctgcgctcgg cgggctggca tccggcccgg gggaaagcgg 1140
accaggtaag ggccccgggg cccgcgcgcc ctggctaggc cagcagaggc tcaccgaccc 1200
<210>10
<211>1200
<212>DNA
<213>智人
<400>10
ttgacacttg gatttggatc aacaatgctt tcaagaagaa agacttttga tcaaaagcgg 60
gaaatgagaa agcgactttc ctctgaaaag tgcctcccag tcccgaggct gcgaggcccc 120
cacgccaggc tggctcccac ggaagccggg cacccacccg gcccgaccaa gcgccactcc 180
gccccgtgga cggggcgtcc caccccgggg acgcccgccc cacaccgcgt ttgcaccccg 240
gaggcccctt gccgcagagg cggacggcgc gcctctcccg ggcccctggg gtccgcgcct 300
ccctcgggca gactctttcg actctgctcg agcctccgct tcttcctgcg ggcggacgcc 360
ccggacacaa cgggccccgc tgttcacgca ggggcgcccc ggcggggcgg gcaaagaccc 420
ggggacgcgg tcccgtcccg agacgctcag ctccggccca ccgctcgcag ctcccgcccc 480
gggcgcaggt cccgacccca cgggccgtct cggagccgca gcggccgctt ccctgcacgt 540
cctcacgccc cccgcacgga cgccgccagc cccgcgcctc agtttcccca ctagcaggat 600
ggaaagacgg gccccgcccc gaagcgtagc ggcgtctccg tggtagccag tgcccagaga 660
gtccgccggt cccaccgccc cttcaaagga gaacccggcc caccgcccgc cgcggcggcg 720
accgcgcagc ccactcgtca cgcggcccgc ggcgtccagc ccgggccggc tcacctcagg 780
cggtcgctgc cgccctcgcg cctgcgcgcc cctcgccccg cccctctccc cgcccgcgtc 840
ccgcgcaccg caggcctctg cccctcgccc accgcaggac ccgccccgcg cacgcgccgc 900
acgtgccaca cgcaccccac gcccctgcgc acgcgcaggc cccaagtcgc ggccaatggg 960
cgacgcggcc gcagatccgc ccggccccgc cctgccctgt gagttcctcc ggccgggctg 1020
cggggctccg ctcagtccgg gagcgcagct gggccgcggc gctccgacct ccgctttccc 1080
accgcccgca gctgaagcac atcccgcagc ccggcgcgga ctccgatcgc cgcagttgcc 1140
ctctggcgcc atgtcgcaga acggagcgcc cgggatgcag gaggagagcc tgcagggtga 1200
<210>11
<211>1200
<212>DNA
<213>智人
<400>11
tgctttcaag aagaaagact tttgatcaaa agcgggaaat gagaaagcga ctttcctctg 60
aaaagtgcct cccagtcccg aggctgcgag gcccccacgc caggctggct cccacggaag 120
ccgggcaccc acccggcccg accaagcgcc actccgcccc gtggacgggg cgtcccaccc 180
cggggacgcc cgccccacac cgcgtttgca ccccggaggc cccttgccgc agaggcggac 240
ggcgcgcctc tcccgggccc ctggggtccg cgcctccctc gggcagactc tttcgactct 300
gctcgagcct ccgcttcttc ctgcgggcgg acgccccgga cacaacgggc cccgctgttc 360
acgcaggggc gccccggcgg ggcgggcaaa gacccgggga cgcggtcccg tcccgagacg 420
ctcagctccg gcccaccgct cgcagctccc gccccgggcg caggtcccga ccccacgggc 480
cgtctcggag ccgcagcggc cgcttccctg cacgtcctca cgccccccgc acggacgccg 540
ccagccccgc gcctcagttt ccccactagc aggatggaaa gacgggcccc gccccgaagc 600
gtagcggcgt ctccgtggta gccagtgccc agagagtccg ccggtcccac cgccccttca 660
aaggagaacc cggcccaccg cccgccgcgg cggcgaccgc gcagcccact cgtcacgcgg 720
cccgcggcgt ccagcccggg ccggctcacc tcaggcggtc gctgccgccc tcgcgcctgc 780
gcgcccctcg ccccgcccct ctccccgccc gcgtcccgcg caccgcaggc ctctgcccct 840
cgcccaccgc aggacccgcc ccgcgcacgc gccgcacgtg ccacacgcac cccacgcccc 900
tgcgcacgcg caggccccaa gtcgcggcca atgggcgacg cggccgcaga tccgcccggc 960
cccgccctgc cctgtgagtt cctccggccg ggctgcgggg ctccgctcag tccgggagcg 1020
cagctgggcc gcggcgctcc gacctccgct ttcccaccgc ccgcagctga agcacatccc 1080
gcagcccggc gcggactccg atcgccgcag ttgccctctg gcgccatgtc gcagaacgga 1140
gcgcccggga tgcaggagga gagcctgcag ggtgaggcgg aggaggcggc gcgggagccg 1200
<210>12
<211>1200
<212>DNA
<213>智人
<400>12
ccaacaattt gagcggccaa gacaggcagc tcacttgaag tcagaagttc aagcctggcc 60
aacatggtga aaccccgtct ctactaaaaa tacaaaaatt agccgtggta gcgggcgcct 120
gtaatcccag ctactcggga ggctgagaca aggagaatcg cttgaatccg gaaggcggag 180
gttgcagtga gccgagatcg cgccactgca ctccagcccg ggcgacagtg cgagactccg 240
tctcaaaaat aaaaataatt agtaaattaa ttcattaatt taagaaaaaa agcgcaatct 300
tcttccaaag gcgatcccaa ggctgttgga ggctgaaacc gctaagtcgc cccctaccgc 360
gcgggtggct tcgtcccgga cccctccaga ggctgtgcca ctgctggagg tgctcagcgg 420
ggccgggacc cgcttggggc gccgtccggg gcgagcaccg gagcccgact gggctgaatg 480
gcaggtcctg accaagccac ccgcgcggcc ccgcccgcct ggcgggatga gtgacggcgg 540
caacaggtgc agagcggcgt ccgcggcttc tcgggagccc ccgagttttg cgagtcaggc 600
cccgagagtc agagtttgac tctagaacct tcttcgcttt acaccagtct tcggaagtcg 660
cccgtcaacc ggcttcttct acctcagtaa agccttaagg tcacctcaac ctctcgaaac 720
ccaccagtcc cagaggccga ctcttctcaa gtggaggaga ggggaaggcg tgcatggagc 780
tttgcctgac cgctcgctct ctcctcccca gccgtctgag agaaggcgag aggggtccca 840
gaaccgagcc ctcgctccgc acgccccacg cccgccccgc tgtgccgtgc gctctgcccc 900
tgagacgccc cggctcggag tcccagggcc acagccgaaa ctcgccctcc cgcgcccctc 960
tccggcttgc agcgcccgcc cgcaccgcca cctgccaccc gaggcgacgc agtccgcttc 1020
tccccacccg ccaggtggca ggttcagggc cggggtccga gcctgcttcc ctgcagctgc 1080
cacagccacc ctcgccgcca gggggcgaga gtcccaggca ggacaagcag cgctgctgcc 1140
ttggcgtgaa ggtggtttca aactttaggc ttcttttccc taccccgcgt ctctgaagag 1200
<210>13
<211>1200
<212>DNA
<213>智人
<400>13
gaggaagatg gaaaccgagt ccgggccggt gagtacggcg atcagggccc cagggcgcgg 60
gatagcgggg agaaggagca gcgtggagcc tgtccctgag ggcttggagg ggcgaggtga 120
aggccccaaa cgctcgctat ctggttggga agaaacgtgg ccaggtgccc catcgaccgc 180
tgccaggagc cacccgcccg cagacctcgt ctggctgtgt catgggggtc agaaaggcgc 240
cgccacgggg cctggactgg gtgtagacgg gccaggggac ctcaggcgtg gatgtttcgg 300
gaggcggcgg gctgccaggc acccagcgaa gtccgagcag gtaaaccgct ttcccgccga 360
aattgggcta ggcagcgtct ttgacgctcc ctgcggccga actcgaccca gccgcccaag 420
gcgaggagtt gccagggcgg tcgacgcctc cactccccga ctggtcagcg aggaccggaa 480
ggtctgagag acctggcagg gcccgcctgt ggcccaggcg ggacccggac actctagccc 540
tggctgtgca cccaagccag tcagggtgga cttggggaag tgaaggagga ctgcccgcac 600
aggcccgagg cgcagcggca acgtgccatc ccgccccgcc ccgtcccgcc gccagcagcc 660
aatcagggag cgccgcgcga gggtggggac cagctgcgca cgaggccagc ggcggggtcg 720
ctgccgttga ggcttcccgc cactgctgct ggcggatttg tggggcaaaa tttctcgctg 780
gctagccttc ttttccctcc cgcactttgg tggggagggg gtggatcctc gtttcggtgc 840
ccaagttcac gatgacccga gagaactcga ggaagttgtc gccgcggcca tttcccccag 900
tgccgcaact tgctggcctt ggagggggag gagcgccgag gcagtgactg cgacggttag 960
cccgcccgtt cctgctgtct tcgtttgcaa aatagatgct agatctcgag gttgattctc 1020
aaggggaggg gccagtgagg gcacattgct ttggaggagt agtttaataa actctctagt 1080
gctggaagtt ttagcaaacg gaggagcctt caaacccggc aacagtcccc atctaggtgt 1140
ttccgtaaca catgcggaat tattgctagt ggaatttcag gctttctttg ttgtttaact 1200
<210>14
<211>1200
<212>DNA
<213>智人
<400>14
ggattttgta tatgtcatca gctgttgtga ccttccaacc catgagaatt ttcctcatgc 60
ctgaggattc acttaaggct acactttcag atccagagat atctttcttt tcctcttggc 120
tgggtcagtc tgactttggc tgcatgatca cacattatta gcaggtgcta ccatttttag 180
gttagaatat gtgactttct taaagtaaaa aaaatcctat agtcctctag cttatcaatt 240
cattaagtta aactttatat accaattttc ttaaatggag gaatgccttt attaatatgc 300
agcatctatg tcattactaa attactatac caacaaagat gaaataattt attgcccaag 360
ttggtctccc ccccacccaa cctttttccc cagttttgtg tggaagtttg atcaggagct 420
ttttccatgg aggttttcag cttccttagt tctaggcaca aagttatgat ctttccctga 480
tgctgaccac cttaggatga tatctgatta ttagtcttgc tactgcgcta ttaagtgtca 540
cttatttcta aggaaatgaa ttgagggtct tggacaggat aaggacagga atgttttatt 600
acccacacta cagatgttgg aaaacaaagc tgaaaactct tttaatttgt gtctatactg 660
acatctgaat gcttaaccca ttattgcttt tttttttggt ggtggtgggt agagatgggg 720
tctcactgtt gcccaggctg gtcttgaact cctgggctca agcgatcctc ctgcctcagc 780
cttccaaagt cctgggatta caggcatgag ccactacatc cctattattg ccttctttaa 840
aaatcttttc ttctctaaaa atctttttag atgttaatta acccatctgg ttgttgtttt 900
tcagtagaga aatggtcaga aggaacgaca ccacagaaga aattagaatg tttaaaagaa 960
ccaggaaaaa catctgtaga atctaaagta cctacccaga tggaaaaatc tacagacaca 1020
gacgaggaca atgtaaccag aacagaatat agtgacaaaa ccacccagtt tccatcagtt 1080
tatgctgtgc caggcactga gcaaacggaa gcagttggtg gtctttcttc caaaccagcc 1140
acccctaaga ctactacccc accctcatca ccacctccaa cagctgtctc accagagttt 1200
<210>15
<211>1200
<212>DNA
<213>智人
<400>15
taaggctgct tgtactctga taatcatgat tatggtgtta tttagagccc agcccaaata 60
cctgagccta aatgagtgaa agagcagaga gtgggcgttt ttttgttttt tttgttttgt 120
tttttgtttt tttgagacgg agtctcgctc agtagcccag gctggagtgc agtggtgtga 180
tctgggctca ctgcaacctc cgcctcccag gttcaagcaa ttctctgcct caacctccag 240
agtagctggg attacaggca cccaccacca cgaccggcta atattttgta tttttagtag 300
agacagggtt tcaccatctt ggccaggctg gtcttgaact cctgacctcg tgatccaccc 360
gcctcggcct ccgaaagtgc tgggattaca ggcgtgagcc accgtgcccg gcagagtggg 420
cgtttttaaa tgaagcagta ttcctttagt ttggtaaaat tgagctgaag ttacacacag 480
taacaccttg acttgttgct gacggtgtgc tttgtgggga tagttggtgt ctgatctcaa 540
ctgtggagaa acaggaagtt tctggattca tgctgaactc ccattccaca ggcgagtttc 600
acaaaagaaa aagtgctctg ttgcatacaa ttattcactg tgtgtctaca acgtggcaga 660
aattattatt cctaaaggtg accgaagaga gctatagttt atggggccag gagcaatgtg 720
tggaatggcg aggcagtgac aagacagcac tgccataaat ctcttacttt ctttccaaac 780
gagctctaat tttaagctca acgaccaaag acggagaggc agtcgctttg agctactcct 840
ggctatttgt tgggaaatca cctaaatccg ttcagattta gccagaaaag gggaaataag 900
tctccctcgc cggccaaatc atggcctttg tcgctttcgg ctccccattg gctgcggccg 960
ctgtggcccc gcctccttga gtggtgcgga gctttgtgat gcggagcttc gtgatgcacg 1020
ccccgatgcc tgcggggcta taaaaacgct cgcaagcgcc aagtctcctc aggagccgcc 1080
ggcaaggggg caacgaggaa gctcttaaga gcgcggccgg aaagcaggtg gggagaatct 1140
ggagaaaagg cgcaccctgc ggcctcggag accattatgt ctcagggagt ctctcgcagt 1200
<210>16
<211>1200
<212>DNA
<213>智人
<400>16
tggaaaatca gacaccagac ccctcacctg caacaattgc ctgatgcctg ttgacccact 60
cctcttcatc tctccctaac tcctgctatt ttcccacatg cagttacatt tcttccctgc 120
tatatcctaa ttttaatcag ttgagaagat ggatttgaga ctgatctctc ccccctaggc 180
tgtagcaccc aaataatgcc ttcttccctg acaataatgg ggtctcagtg actggctttc 240
tgtgctgtga accaccagac ctagaccaaa ctcctggcat ttctctaaca atttcccacc 300
actgaactaa gttataaatt ctgaggatgg atccctgttt cttcatttta agatggggat 360
taaaaggtac atcctagagt gttattgtcc gtgtaaaata gggctgtgaa accccctaca 420
cctatgcaca gataaactga tggccctgca aatgcccaga gaagtaacct tataaagatt 480
tagtgaatgt ttcccaccat tattggaaaa tctggctaag tcagtagctt tgttttcata 540
tacttagggg gaaaatcaac aaaaacttga tgccctgtta tttccttcca gtttcttctg 600
caactctagc tccaaagact gcagttcctg cagtattttt ttttttagaa caccaggaaa 660
aaaagaaaaa aaaaccatgc aaatgtacta tttcttcaaa cacaactagg aatgattgaa 720
cagctgggag aatatgaaga aaacccctca gagaaccaag ggcaagcagt gagttcagat 780
ctaggcacat ggccactagg aatggttctt cactgccacg tgggcagcca acagccagta 840
gctagagacc agcctcggtc ttcggcctgc gggttctgca aagtcaggct agctggctct 900
ccgcctgctc cgcaccccgg cgaggttccg gtggggaggg gtagggatgg ttcagccccg 960
ccccgctagg gcggggcctg cgcctgcgcg ctcagcggcc gggcgtgtaa cccacgggtg 1020
cgcgcccacg accgccagac tcgagcagtc tctggaacac gctgcggggc tcccgggcct 1080
gagccaggtc tgttctccac gcaggtgttc cgcgcgcccc gttcagccat gtcgtccggc 1140
atccatgtag cgctggtgac tggaggcaac aagggcatcg gcttggccat cgtgcgcgac 1200
<210>17
<211>1200
<212>DNA
<213>智人
<400>17
actcaagcac cagcaagcgg actcgaactc aaagggtttc agggtgtaga cgaccagagc 60
gcactgaggg gctccaggtc ggcccgctcc ggagccggga gagtaaccgc gtgcagggaa 120
aggcgcacgg cagcctcggt gcctcccttc cctccaccgg acgggtgact gactaggggt 180
gaggtcctca cctccaggct gcgcagctga gttctggaag gtactgtcct gggggtgtga 240
gtgtgtgggc cctcaggaaa ggtgcgaggg gcggatgccg tggtctaccc gagcttgcgg 300
gggtgcggtg gtcaagttcc ccaggaccct cgctggcgcc gcttgtcgac aacggggaac 360
agtgggcgcc gcgggtggtg gtaacttggc ccgggaagaa aacacatccc tttcccaaac 420
cggattcctc tgagcaaaac cagatggtgt catccgcatt ttacagctgc gtcaagagag 480
gcccaggaca ccaagagcca gctgtggcca gagccctttc actgacccag aacactggcc 540
ctcggaaacc tggagaactg cgagggcttt taatgcggct gagaagaaag tgaagacccc 600
gactcctcct ctctccttcg aaagagccga cacaggtatg aagaccagcg cctcggacgc 660
tccggggtag ggggccgacg ccccctccct ttcagaatca cgccttgctg atgctcagtc 720
ctgcccagtg tccacccccc acccccgccc ccagtttcct ttctagcccc tccggtcccc 780
aaagcgaact aagctagcgg cagcttctcc atcccggagg agactccaaa ctcctaggtt 840
tcccaccttg gagagtactg ctctggaatg cgcaggggag cggcacctgg aaagggttgg 900
gcggaagctt ctcggaccca gagggggcgg acacccggca ccgcgcgtgg gagggattaa 960
ctccacccca ctagaccacc tccccctctc tcccaggagc cacttcaacc ggttgtcgcc 1020
ccagtggccg ccctctgagc acgtgttact gccagtctgc gtcagcgttg ggtaaataca 1080
tgactggccg acgccgccgg gtggggctat ttaagagaca gccgcccgct ggtcctccct 1140
gaacttggct cagctgccgg gctgctccgg ttggaaacgc caagccagct gcgtcctaat 1200
<210>18
<211>1200
<212>DNA
<213>智人
<400>18
cctcttttcc gtttgcattt tgccccatat tagaatgcta ccatctaaaa ccgctccatg 60
aattagaaag tttaagttgt cagggactga atgtgtctgt tttccaacag tttctggcag 120
ttccctgctt ttatggtgta gtcatggtga aacctgagtc atctgaagat ggtggcagtg 180
ccagagagca ggagagagga gctgcaaaga agccagacag cgttgggcat caataactcc 240
tgggcaccac cggccactgg ccttcattct gacaggagag ccaacccaac cctaactgtg 300
ttcagagatt gctccaagct ttacagttct accaaattct ttctgtagca aaaatataaa 360
ggcatcttct taggtaattt tttttcaggg ttccaagtag caacacctaa cgtctgcagt 420
gcgagttctc ttcttctttt tttttttaag gtgataaatc ataacatttt cctggaaagg 480
aaagcagtag acctcatttt ttgttttaag gaaaaatagt ttttctgttt ccattcatat 540
acattaaata actacccagg aaatacgccc cggttttgcg cgcgtgtgcg tgcgtgtgtg 600
tgtgcgtgtg tgtgtgtgcc gtttctctaa aattctgact catagtctgg aggacaatga 660
ttgacttttt tccacttcac atagttgcta tgaatttctc ctcacaagga tgggcctgtt 720
tactcaccct gggcatcgtt ggtagagcgc tagtgtaaac agcctgagga acccggtggg 780
ccggggaagt gggcgcgctc tgttctccgc ggccagctgg gacgccgggc caggtggggc 840
cgcctgcgtt tagcaactgc tttctcaccc cctggatttg cgatgtttgc cacagcagcg 900
agaagcgcca ttgtaatggg gatgggaggg gtggagcctc caagtcctgt ctcaatttag 960
atctctcact ctgctgttag gcgcgcccat ttcagattac taaactcgaa ttaagaggga 1020
aaaaaaatca gggaggaggt ggcaagccac accccacggt gcccgcgaac ttccccggca 1080
gcggactgta gcccaggcag acgccgtcga gatgcagggc ccaccgctcc tgaccgccgc 1140
ccacctcctc tgcgtgtgca ccgccgcgct ggccgtggct cccgggtagg aacgtgggcg 1200
<210>19
<211>1200
<212>DNA
<213>智人
<400>19
atgcgtgctg aagtatgtag gggtaaaatg acatgatgtc tggaatttgt tttaaaatac 60
ttcagaaaag cggggagtag gtgaaataag tgtgacaaaa ccttaatagt tgttgaagcg 120
gggtgatggg tacacagcag ttcattatac aattctactt ttgtgtatgc ttgaaacctc 180
tcaattaaaa aaagagggta gagagtcatc aagataattt actaaaagtt tcctgtaatg 240
tccccagaag acccccctaa ctcacacaca cacacaccca cacacacact gccttttgag 300
aactttctct agaaggccaa cccaggcagt cccccaactg taaggaagac tcgtgtatgt 360
atgtgcatat gtgcatttcc ccagggaaaa acatccacag cttccatgac gagaggggtc 420
gtgacccctc cccgccaaaa gattaaggac ctgcgatcct acagaccgga gccctgtttg 480
aagtctgcgt tgcccctcac ctcaagctgg tcactgtgtg aagttggcct agaatccccc 540
ggcccctggg agcttgttcc tccgcctgta aaatggggct gcagggccgt ccacgcggcc 600
accggaagga caaggtgttc aggccgctag gccgctccct ggcaagcgat tcccactcgc 660
agcgcggcct cgaccctcgc ccaagacgcg ccctccgcgc ccccaccccc tccaggccct 720
ggccagtcca cctcccgctt ggggcggcaa tttgtctcct tttgaacccc ccgcccccga 780
cgggtttccc cctttgattc gcggcccgga ggcttccccc cgctttgaaa tgcaaacccg 840
cctcggctgg ggccgcgggc ggcccggagc tataaaaggc ctgggtgggg cgggcgcggc 900
ggcaggacag ccgagttcag gtgagcggtt gctcgtcgtc ggggcggccg gcagcggcgg 960
ctccagggcc cagcatgcgc gggggacccc gcggccacca tgtatgtggg ctatgtgctg 1020
gacaaggatt cgcccgtgta ccccggccca gccaggccag ccagcctcgg cctgggcccg 1080
caagcctacg gccccccggc cccgcccccg gcgcccccgc agtaccccga cttctccagc 1140
tactctcacg tggagccggc ccccgcgccc ccgacggcct ggggggcgcc cttccctgcg 1200
<210>20
<211>1200
<212>DNA
<213>智人
<400>20
aggcgctcat ttaaaattcc agtcttgctc ccgagggctt tggcctccat cttcaccttt 60
aacgaccgag ggctggtggc ggcggctcct tcctgctctg cgacaggtgt cgcttctgag 120
cgggagtttt gggcacagac atcgcagatc cgcaccaccc ctaggggtct gcatgggttt 180
cagctgcacc cagcctggag gggctttttg gaagggggca cgtgggcggt gggagcgggg 240
aagcaggtga ggggagcccg cctgcgcgga tttttctgct gtaaatcaga cccacagtct 300
ccagagcgtc ttttccccaa gtgtggaaca catttttctt ctaatcctct ttggagaggg 360
ggttaggaac gtgccgaggc cggagccggg agcggggtgg gtcccggcgc ctgtgaaccg 420
agtgggggag cgggccgcgc gctgccctga agaccctgcc tccgcgccct tgggggctcg 480
gggcccagcg ccttcgcagg cgagcggcgg cggctggctc tgcccggggt gcgcgggggc 540
ggtgtttcct cgcctccccc tgcgcccggg ctcgccaagc cccgactgcc cgctcggccg 600
tcgggtccgc gggcgcgcgg acgcctcgac ggctccccct gccggggcgc cccccggtcc 660
ccaccctcac ccggcggctc aggactagtc ccccaacttg ttctctgctg ttaactagtc 720
gcgctgccgg aacgatggga tggggttgcc acagcaacca gactggacgt cacaatccgg 780
gcatgtgtgc cgcccccccg ccgtgccgcc gtgcctctgg cgctgccgcc gccaccctcg 840
gccggctgcg ggactcgggc tgcggggcgc ggtgggagga gcgcccgggc tttgcgggga 900
gcaggctaag gcggccgaga gaaagggggg tcgagacggg ggggtggagg tttggggggg 960
tgggggggca ggcggccgcc atcttctcgc cgaggccgcc tcgcccgccg cgcgcgccgg 1020
tccggcagcg cacgggttaa ggctggcacc gcgcccggcg ggaggggggg cgcccacctc 1080
ccctcctccc cgcgccgggc atgcggggcc cagtgggcac cgaggaggag ctgccgcggc 1140
tgttcgccga ggagatggag aatgaggacg agatgtcagg tgagcggggc gcgggtgcgc 1200
<210>21
<211>1200
<212>DNA
<213>智人
<400>21
cctctcggcc tttgctgtca ccaaggccaa aggaaggctg gctgtgtggt gtaccttgca 60
cctccagaat gccttcaggt gtgatgtggc accacagatc tggtaggtgg aggaaggggt 120
gggccatttt acagatggga aagcaggctc tggaggcttg gatgagtttc cgaggacagg 180
tagtagcaaa gctgggacct gctatcccca ccagagctgt ctccctgaat cagtcacccc 240
cgaccctgtc cagtcagaca gcaccgcctc cttggagggc caaggctgct cccacccatc 300
tcagggcccg agtggtgtgg tttgtggctg ttgtatttct tgcctttgcc agccagcagc 360
tcactgtcac cctagcatct gtcagggccc ctgcagtgtg tctgtgggct gccagagatg 420
gggcctcatt gtcccagcct agacgcacgg tgcctgggtg cagccctgcc ccgggtgagg 480
gatggtggat ggggctgccg tgtccctggg ctccagcaca gggctcatgc tccctgagtg 540
cttggggatc acacagtgat gtgacctctt ttcagggggc aatgggaaga cctaaggtag 600
gggaagtcca gaatctcatg ttctgctccc tgctctgctg tcccttgccg agtgggcctc 660
agtttccccc tctgtcctat gcacatggca gtctcaccta cgctggctca gatattctgg 720
gtgccgataa gttcaccatt gagtgaaagg gccacgtggt ctcacagacc cccactgccc 780
atctcctgtg tgcatgaccc atgcggctcc tggggacggg gtggatgtca tggcgtcacc 840
gtggtactgt tctgacttgg gggcagtggc actgatggga gggagcctgc atggcagcct 900
gctgtcatgg gagcctcagg gtggggccct gcagctgagc cccaccttgg ggacccttct 960
ctgtccacag tgccccccac tgaagggcaa agtccagcgg attctacact ggaggtggac 1020
ggagccccct gcccccttca tggtggggct gccggggcct gacgtggagc ccagcctccc 1080
tccacctaag cccctggagg gcatccctga gagagagttc tttgtcaagt gggcagggct 1140
gtcctactgg cattgctcct gggtgaagga gctacaggtg agtgcccggg agggtggctg 1200
<210>22
<211>1200
<212>DNA
<213>智人
<400>22
cgacaggtgt cgcttctgag cgggagtttt gggcacagac atcgcagatc cgcaccaccc 60
ctaggggtct gcatgggttt cagctgcacc cagcctggag gggctttttg gaagggggca 120
cgtgggcggt gggagcgggg aagcaggtga ggggagcccg cctgcgcgga tttttctgct 180
gtaaatcaga cccacagtct ccagagcgtc ttttccccaa gtgtggaaca catttttctt 240
ctaatcctct ttggagaggg ggttaggaac gtgccgaggc cggagccggg agcggggtgg 300
gtcccggcgc ctgtgaaccg agtgggggag cgggccgcgc gctgccctga agaccctgcc 360
tccgcgccct tgggggctcg gggcccagcg ccttcgcagg cgagcggcgg cggctggctc 420
tgcccggggt gcgcgggggc ggtgtttcct cgcctccccc tgcgcccggg ctcgccaagc 480
cccgactgcc cgctcggccg tcgggtccgc gggcgcgcgg acgcctcgac ggctccccct 540
gccggggcgc cccccggtcc ccaccctcac ccggcggctc aggactagtc ccccaacttg 600
ttctctgctg ttaactagtc gcgctgccgg aacgatggga tggggttgcc acagcaacca 660
gactggacgt cacaatccgg gcatgtgtgc cgcccccccg ccgtgccgcc gtgcctctgg 720
cgctgccgcc gccaccctcg gccggctgcg ggactcgggc tgcggggcgc ggtgggagga 780
gcgcccgggc tttgcgggga gcaggctaag gcggccgaga gaaagggggg tcgagacggg 840
ggggtggagg tttggggggg tgggggggca ggcggccgcc atcttctcgc cgaggccgcc 900
tcgcccgccg cgcgcgccgg tccggcagcg cacgggttaa ggctggcacc gcgcccggcg 960
ggaggggggg cgcccacctc ccctcctccc cgcgccgggc atgcggggcc cagtgggcac 1020
cgaggaggag ctgccgcggc tgttcgccga ggagatggag aatgaggacg agatgtcagg 1080
tgagcggggc gcgggtgcgc ctggggccag agcggcgggg gcgccgagac gggccgggcc 1140
cagggcggag cgcgggcggc gggggcggcg cggccgggct ggcgcctcgc aggaggggca 1200
<210>23
<211>1200
<212>DNA
<213>智人
<400>23
gcatgaaatt gagataaaac atttcaacag actggacaga ctctgaacac tgttgaagag 60
aacattgata aattggaacc tggtgctgag gcattttccc agaatgcaat gtacagagac 120
aaagataaaa cagggagaac atggaagaca ccttgagatg ctccaacaat catccaattg 180
gagttgcaga agaaacagaa aaaatggtga agaagttgga tttgttgaga gtttgcagac 240
ctggagagaa atgtgaggtc tcagatctgg agtgcattct ggaatagcaa gcaagataaa 300
tataaataaa tgaacccgta gacacgttag aacctctagg tactttagac ctagtaccta 360
caaaataagg gcagccagat cgttctcaga cttcttaaca acaacaggtg gcagagacca 420
tggcaaaatc tccggtgcac tgagggaaaa tgtgtgctga tagttttata tccagctaaa 480
ctctctctcg agaataaagg gaattatacg gggtcatggg agctcagaag ggactgcctt 540
tcttttctta tggggaggag tgaaatcagg gaagacatca cagaggtgat gtttatgttc 600
cctaggcagt aagggggtgg gcattccagg aagagagtca ggtagtttgg aatggctggg 660
ggctgtgaag gagcactcgt cctgcagcgc cttgaataca gggcagtgag atggaactta 720
attctgtgtg gtgggagcag gggaggctca tgtcagagcc ctgatttagg taagtggctg 780
tggggctagg caggaggatg gattggctcc aaggggtgag gttggaagct ttgttcttcc 840
ccagagtcct gcattgggcc tgcctgggtc ccagctgtct ccccacctag caggcagctc 900
tctcctcccc tgcctgtggc ggggtccccg cccatggccc atggggcccc ttgctccttg 960
gcagttcctc acgtgcccgt ctcccctgca gatgaccaag atgctggacc tcctggagga 1020
cttcctggag tacgaaggct acaagtatga gcggattgat ggtggcatca ccgggggcct 1080
ccggcaggag gcaatcgaca gattcaatgg tacccccatc ctgcccaagg gttctgattg 1140
agactccttt ttggcctctt ctcccaggcc tggttcttag ccaggtcacc cagctggtgt 1200
<210>24
<211>1200
<212>DNA
<213>智人
<400>24
gaaatctacc tatttgtaac tccagggaag taaatgagat aatgtttgga agatatctag 60
tctaccagct gctcaggcgg ggggcgaagg ttctgttccc tgtcccttct ctatcaaatg 120
gctttaaaat cagaagaaag tattacgggt aggaaatggg actgcgaaaa aaatggaggc 180
tgattctggc ctaaaggata cttatctcta tacaaagggc ttctgattca aagaggcccc 240
gggattcaaa aacacaagca gagctacacc acgtggggtt tgggacgagc tgaattccgg 300
ataaagatgc ctgtaaagag gagttgatgc gaatccagaa aagcacttga aatgcccagg 360
ctttgcatgg cacattcccc aggatttttt cgcaccgcat ttagaggttt agacggagtg 420
agctcgaatc aggccaaaag ccttaggtta ctcctgggcg gcagcggggc agaggtcaga 480
tcaacaggtg tggaaggctg cgaggtgagg gaagaagcag gtgtcggtgg aggccccagt 540
tcctccggcc cagaggctcc aacgctgcta ttggtgttcc agcagcgggc ggaggggtcc 600
tgcccggcat ctgggcgcgc tgggcccaga gcccgggagg aggcagacgg aggcggcggg 660
tcagcggcgg gccagccccg gtgggcttcc gctcccctcc gccggcccgg tccggcccgc 720
cgcggaggat gcctggaggt tgacgtgaat ggcctgtggc tgggaagccc ccaggcgccc 780
tgcctagccc gggggcgggg ccgcctagcc gccggccccg gtggcgtgag ggctggggcg 840
ggggccgggg acctcgcggg gagggagcgg gagggaaagc ggcccccgcg gcccttcaat 900
tggccgcacc gcccctcggc gcagaggcgg gaggaggcgg ccctccattg gtcgggcccg 960
gcggccaatc ctcgaaggcc caggcggagg cgggggcggc ctgtggggaa ccgaggtgcg 1020
ggcggcgagc gaggcagccg ggtgcttcgc agcggagctc gaggctctgt agcacccagt 1080
tggacccagt cgcccaggca ccgcccgcgc cccgcggccg tctcctgcgc ctcccagagg 1140
agggagttcg agcatccccc gcggcggcca ctcctcgggg ccaggagcgg ggaagcgaag 1200
<210>25
<211>1200
<212>DNA
<213>智人
<400>25
gatctcaggg attgaaatct gtcctaggtg tgcaccagaa agtggtggca agagatgaag 60
cttcggagga ggctgacctc ggccaggatt cttaagtctc aaagtttcag ctttctcacc 120
cctcaacgga catgaaatct acctatttgt aactccaggg aagtaaatga gataatgttt 180
ggaagatatc tagtctacca gctgctcagg cggggggcga aggttctgtt ccctgtccct 240
tctctatcaa atggctttaa aatcagaaga aagtattacg ggtaggaaat gggactgcga 300
aaaaaatgga ggctgattct ggcctaaagg atacttatct ctatacaaag ggcttctgat 360
tcaaagaggc cccgggattc aaaaacacaa gcagagctac accacgtggg gtttgggacg 420
agctgaattc cggataaaga tgcctgtaaa gaggagttga tgcgaatcca gaaaagcact 480
tgaaatgccc aggctttgca tggcacattc cccaggattt tttcgcaccg catttagagg 540
tttagacgga gtgagctcga atcaggccaa aagccttagg ttactcctgg gcggcagcgg 600
ggcagaggtc agatcaacag gtgtggaagg ctgcgaggtg agggaagaag caggtgtcgg 660
tggaggcccc agttcctccg gcccagaggc tccaacgctg ctattggtgt tccagcagcg 720
ggcggagggg tcctgcccgg catctgggcg cgctgggccc agagcccggg aggaggcaga 780
cggaggcggc gggtcagcgg cgggccagcc ccggtgggct tccgctcccc tccgccggcc 840
cggtccggcc cgccgcggag gatgcctgga ggttgacgtg aatggcctgt ggctgggaag 900
cccccaggcg ccctgcctag cccgggggcg gggccgccta gccgccggcc ccggtggcgt 960
gagggctggg gcgggggccg gggacctcgc ggggagggag cgggagggaa agcggccccc 1020
gcggcccttc aattggccgc accgcccctc ggcgcagagg cgggaggagg cggccctcca 1080
ttggtcgggc ccggcggcca atcctcgaag gcccaggcgg aggcgggggc ggcctgtggg 1140
gaaccgaggt gcgggcggcg agcgaggcag ccgggtgctt cgcagcggag ctcgaggctc 1200
<210>26
<211>1200
<212>DNA
<213>智人
<400>26
gggatggagt attgcagcct ctcgccccac agacttgtga acagggcgtg gggacagaca 60
cccagctcct agggccatgc cacccccacc cctgcccgcc tctcgcagca cctttcctgt 120
ggatctgacc cccttccaga cacagaagta agccagcacc cagcagacac agggtcacct 180
cccagctccc taccaggcaa gagcgaccag ggcagggact gatactgccg aacccaggag 240
ccaggcccga cccagcctca ggtccagcag gtcccgcctg tccacctggg ccaggcctag 300
agcccgggag cccctggctg gtgggaggcc acccgcaacc caccccacac gcagctccag 360
ctcccccacc aggcggggcg actaggacag ggacagaacc cgttgaaccc aggagtgaga 420
tccggccccg ggtcccgctg ggccctcccg tccaccttgg ctggacctgg cgcctgggag 480
accttggctg gcgcgaggcc acgcccacca gacatgcagt tccagctacc ccaccagctg 540
ggcgaccagg acagggacgg aggctgctga gcccagttag aggcctgccc cccggggtct 600
gtcctgggcg ctcccccaag gacggacagg gcaggcaggg tccgggacga tggccgcaca 660
gtcccggccc cgtgttccca ggcccgtctt gctcctcgat gtgagggaga cccgggggat 720
gggacaggct gggccccgca gtgcctgact ccctgcaggg ctcccgggac aggggtccgg 780
cggacagccg gctgctcacg ggtgaggggt ccaagctggc attgcggcca ccttccggcc 840
cgggctctct tggggagggg cggggttggt gagaaccggt cacgtgctcc ggggctcact 900
cggggtctcc cagggccgga agtagggccc ctgtgcgcag gcgccctgag gatcccgggc 960
tgcccatctc acgccagggg gcggaacttc ctgcagcctc tctgcctccg catcctcgtg 1020
ggccctgacc ttctctctga gagccgggca gaggctccgg agccatgcag gccgaaggcc 1080
agggcacagg gggttcgacg ggcgatgctg atggcccagg aggccctggc attcctgatg 1140
gcccaggggg caatgctggc ggcccaggag aggcgggtgc cacgggcggc agaggtcccc 1200
<210>27
<211>1200
<212>DNA
<213>智人
<400>27
ttgcagcctc tcgccccaca gacttgtgaa cagggcgtgg ggacagacac ccagctccta 60
gggccatgcc acccccaccc ctgcccgcct ctcgcagcac ctttcctgtg gatctgaccc 120
ccttccagac acagaagtaa gccagcaccc agcagacaca gggtcacctc ccagctccct 180
accaggcaag agcgaccagg gcagggactg atactgccga acccaggagc caggcccgac 240
ccagcctcag gtccagcagg tcccgcctgt ccacctgggc caggcctaga gcccgggagc 300
ccctggctgg tgggaggcca cccgcaaccc accccacacg cagctccagc tcccccacca 360
ggcggggcga ctaggacagg gacagaaccc gttgaaccca ggagtgagat ccggccccgg 420
gtcccgctgg gccctcccgt ccaccttggc tggacctggc gcctgggaga ccttggctgg 480
cgcgaggcca cgcccaccag acatgcagtt ccagctaccc caccagctgg gcgaccagga 540
cagggacgga ggctgctgag cccagttaga ggcctgcccc ccggggtctg tcctgggcgc 600
tcccccaagg acggacaggg caggcagggt ccgggacgat ggccgcacag tcccggcccc 660
gtgttcccag gcccgtcttg ctcctcgatg tgagggagac ccgggggatg ggacaggctg 720
ggccccgcag tgcctgactc cctgcagggc tcccgggaca ggggtccggc ggacagccgg 780
ctgctcacgg gtgaggggtc caagctggca ttgcggccac cttccggccc gggctctctt 840
ggggaggggc ggggttggtg agaaccggtc acgtgctccg gggctcactc ggggtctccc 900
agggccggaa gtagggcccc tgtgcgcagg cgccctgagg atcccgggct gcccatctca 960
cgccaggggg cggaacttcc tgcagcctct ctgcctccgc atcctcgtgg gccctgacct 1020
tctctctgag agccgggcag aggctccgga gccatgcagg ccgaaggcca gggcacaggg 1080
ggttcgacgg gcgatgctga tggcccagga ggccctggca ttcctgatgg cccagggggc 1140
aatgctggcg gcccaggaga ggcgggtgcc acgggcggca gaggtccccg gggcgcaggg 1200
<210>28
<211>1200
<212>DNA
<213>智人
<400>28
ttgtgaactg cctgtggaca gggcaacatg gcagagaact gagggcagct tttataacaa 60
attaagagat ttcttaatat ttaaccctcc ttacattaac tgctcgtggt atattattct 120
ttttaaaaaa ttatttatac tttttgtggg tacataatag gtatacgtat ttattggata 180
catgaaatgc tttaacatag gcacacaatg cataatgatc acataatggt aaatggggca 240
tccattcccc tcaagcgttt atcctttgtg ctacaaacaa tccaattata cttttagtta 300
tttttaaatg tacaattaaa ttattttgac tgtagtcatc ttgtgctatc aaatactagg 360
tgttaataat cacatcatgg agaatggagt atccatccct caagcgtggt gcattactct 420
ttgaatatgc tgctctggat tgtatttgct aatatgtggg gcttctctat taatgttgca 480
aaatagggag ccaataatct ggttgagaga tgaaagcagc agcaggaaaa tgtgttcaca 540
gaacctcata cgagtggcgt ctagggccaa ggctccttga atgcataccc aagggctgat 600
gagaggtggg gacgagtgct gccgaaggac tcctcaacta ccagaactac gtagggcccc 660
taacatcccc tcggagcgag ctccccgcgc cccgtacacc accaggtctc cctggttcct 720
ctcctgctcc ccgtcccgct acctcaggaa actttagccc agcctctccg atacaagccg 780
gcctccttga gggctttagg cccctcttcg ccagtgtata ccccacgaca cgcctgcgta 840
ctagggacca cccggctttg tgggcggagt ccatgagagg gttggagccc cgctcgtggc 900
cccgcccacc caagcctagg ccggccttcg tggacacgca tttccggcga cgcctcggta 960
ctgacctctg cagagccggg tggagcccat tgacgtccag cgaagcgagg agcagcgatg 1020
gacggtcggg tgcagctgat aaaggccctc ctggccttgc cgatccggcc tgcgacgcgt 1080
cgctggagga acccgattcc ctttcccgag acgtttgacg gcgataccga ccgactcccg 1140
gagttcatcg tgcagacggg ctcctacatg ttcgtggacg agaacacgtt ctccagcgac 1200
<210>29
<211>1200
<212>DNA
<213>智人
<400>29
tcgaatctgc agtgagtgat cgcaccactg cactccagcc taggcgacag aggtcaaaaa 60
caaaacaaaa gaaaacaaac aaaaaaaaca tagcaaacat ccagaagact gtgtagagca 120
atgaatgtct ctcaagccag tgatcttttt ctcttcattt ttcacatcag gtgggtagtg 180
tgcccacttc gtaacaaggt ttgagggagg cacatttgac acaagagcat gaaaacccaa 240
tcacacttat gacttacaaa aggatcaagt cagtgatctt taagctgtgg gccattaaat 300
acattttgtg agccgagtgc agtggctcag gcctgtaacc ccagcactat gggaggtgga 360
ggtgggagga tcacttgagt ccaggagttc aagaccagcc ttgggcaaca tactgggaac 420
tcccatctct attaaatttt ttttttttaa ttttgtggat tacaaccatt tcaaaaacta 480
aaataagcgt aaatgtatca aaatgcagct tacatagcga ggataaatgc tgttttgtca 540
atctgttgtt tcaagttttt tatgtgtgga ttgggtcacc ttgtaacagt gacttacctt 600
tatgggtcac ggttgaaaac atttccggtg cagtggctga ctgtaatccc agcactttgg 660
gaggccgagg ctggaagatc acttgaagcc agaagccaag agttcaagac ctgcctgggc 720
aacacggcga caccccgtct ctatttaaaa agaaaaaaaa aagtttccaa ggcactgaga 780
tgccaggaac ccgaggtgtg tgtccagtag gggagggagc aaattgggcg tttggaaaaa 840
gtcccacgcc tggaaaggaa tacacagtgg gggggtgggg ggcggggcac atcgactact 900
tcaaggcaca ctcccacggt tcagaaaacc gattggctaa aactgggaaa gtcccgccca 960
caacgctcac tggccaatgg ctgcgtgaaa tcagtgcgaa gtgggcggga tagagagcgt 1020
gggcgggggg gctagcctcg tgcgggctcc ttaagtagcg gctgcgtggc ttccctggca 1080
cgctactctt acgacgtcac ggtcaggtgg tgcagagctg gacggcaacg acgtcggacg 1140
cgccccttct tggaacaatg tcccaccacg gaggagctcc caaggcctct acgtgggtcg 1200
<210>30
<211>1200
<212>DNA
<213>智人
<400>30
cctccagttc ggcattagtt tcttcctaat gtccactctg cccgaagtga caagcggggg 60
catgtggaga ctcagctcca ggttcctgga cgggctcagc cacccccaga aagctaatga 120
atgctcaacc agggcttcca gatgcccagg ggacagagca ggagatgccg gggaatgggg 180
ctttccttgc agttcaggag ggccctgccc caggcccaga agtagaaggg aaagcggctg 240
ttttggcggt aaacagtaat gtggggagtg ctgcagagaa aggcagtctt ggggtttcaa 300
gctggagagc agtcagctac actcaggacc tctggccatc cctgccttca cctgctgttt 360
ggcctgatcg tctaacttct ctgattctcc actacccact ccttattacg tttttgagac 420
ttgtcaaagt tttatattag ggctaactgg gacgcataca aatctggtaa cttcgccagg 480
gcgggaagtt aggaaggagc agagctggct gcaggtgtct ggtcctgacc actcctctat 540
gccacccttg aggagcttgc tgactttctc atgacgttct cccattccag gagctgcaag 600
tgcgttatcc tggctggagc acggtgtcaa tcacggcaga ctaaggccag cggtgatggc 660
ttgaatgcca ggctgggggc tgggattttt cctgaggatt tcacaggaca gaggttggct 720
tggaaagacc aaggtgggac tgaggaacat tccccctacc cccaacctcg gtgggctgtt 780
gcaagcctgg aggccagaga agacgggcct gggatgccgc gggcgcaggg gcaggcagtg 840
aaggagatgg ctgccttcgg tagagctggt cgctgaggca gaagaggagg gcgtggggcg 900
tggggcgtga ggtggccggc gccccggctg gccaatggcc gggctgcggc ccctccgcgg 960
ggcggggtgg gcctggtggg cgggcggggc tcggggcggg ggcggagagg gagcctggtg 1020
ggcgggcggg gcgcgtcttg cgggctccct cgggtaccgg cgctgccgca ccccgccgcg 1080
ctcccgcacc cgcggcccgc ccaccgcgcc gctcccgcat ctgcacccgc agcccggcgg 1140
cctcccggcg ggagcgagca gatccagtcc ggcccgcagc gcaactcggt ccagtcgggg 1200
<210>31
<211>1200
<212>DNA
<213>智人
<400>31
gcactacagc ctgggtgaca aagcaagact ctgtctcaaa aaaaaaaaaa aaaacaaaaa 60
aaaacaatta atgccctcgg gtaaactatg acgtttgtgc taacttttca gatgtcccaa 120
gatttgggtt gttttacaag gataacgaag ttcatgatga ggttaagcaa tcactgaagc 180
tagtgctaga aatttttttt aatttaattt tttagaaaga ggggtcttgc agaatttttt 240
atttaatttt ttagaaagag gagtctcgct atgttgctca ggttggtctc caactactgg 300
gctcaagtga tcctcacgag tagctagggc tacaggcaca ggacactatg ccaggcttag 360
tgctacaata ttctgtctat tttactttaa aatattctaa gtatgctcac tttggaaggc 420
atcaacatcc agaaatgcat tcctacatca agactctcaa gaaacgggaa ttactgtaag 480
ggcataccct tgagcaacca tcacactgca ctgaactctt gagaatattc tggaatatcc 540
tggaagcatc tctgcagggc agagaagtga actgccacag aaggagcagc tttggggaga 600
agaaatacag tttgcctctt acagtatttt tctacaccga gagctacatt cctcccgagt 660
tttaaatttg tggaccgttg aatatcactc cgcctttcat aaagttacaa ataccttccg 720
tcggtggcgg gaacagagtt tggaaaatta catgcctaag acttcagata agctaaatga 780
catacatgca atagcatccc atgaagaatt tattcaaccc aatccattgc atctaattac 840
ccaaagcaca gaaactctcc aaactgtgca ccccccaaaa ggagggaaaa tgcaaggttc 900
ctgctgcagt tcccgggaca cactgcgagc cgctttgtta caagtgtatc caatgtcccc 960
agaacgaggg acttgtgggg cgcggctcat cccagcgcca cttgctctgc agctcccaga 1020
ggtggtggtt gtgttacgaa ggctgaccct gccaatggcc gacaaaatgg tgcgcacccc 1080
caagtgctcg agatgcagga accatggctt cctggtgccc gtcaagggac acgcgggcaa 1140
atgccgctgg aagcagtgcc tctgcgagaa gtgctacctg atctccgagc gccagaagat 1200
<210>32
<211>1200
<212>DNA
<213>智人
<400>32
atatatatat gtgtttatat atataatata tattatattt gtatacacac acacatatat 60
gccacatttt ctttatccat ttatcccttg atggacactt aggttgattc catatcttgg 120
caattgtgaa tagtgctgca ataaacatga aagtacagac gtctcttcaa cacactgatt 180
tcaaatcttc ccagtaaata cccagaaatg agattgctgg atcatatgat aattctactt 240
tcagtttttt gagaaacctc catacaattt tccatcatgt ttgtactaat ttacattcca 300
ccaacagcat acaagcattc ccttttctcc attcttgcca acacttgtta tcataaaggg 360
aggtttgaga gaccataaaa caaaccccac ctcacaattt tgttagtgca agttctattt 420
ggcctattcc caacactaag cacacagtag gtggcaaata tttgttgaat ggatgaattc 480
tcatttttct ccatttgtgg aagcagacac ctcctcaaaa aaaaaaaaaa atccgaaaga 540
aaaggtaaag gaaacagttc tatgaatggg ggttaattta ctctcctagc attcacttat 600
tgggaaaaaa agtaacagca gtttctagaa ccctctggtc tctgagggag atgctgtgtt 660
cccctcctca gagaagaaga aaacgcacta gagagtggga gcatccccaa ggctgaagcg 720
catccaggac atcacatgtc aacgtgtcct ctctggcgtg gggtccccgc gagtctggga 780
aacgaggagc tggcaaggga gggcaagcgg gggcggcaaa gagggcccct ggagcagggg 840
gcgcggacct cgctgcgctg cgcgctctac cgccgggctc gcaacgctgg gctcagcgct 900
cgcgcctccc tcagctctct cctccgcccc ccttcgccct ccccctttcc ctccctttct 960
cctcctcctc ctgccgccgc ggccgctgcc ggacttcgcc agatcagacc cacggggctg 1020
ccctcccctg cgcactcccc tcgctgcccg ggcccggagc gcagcgcggc cgcacaggta 1080
ggagccccca acggggggtc gccccgagcg agcccagtac tcactgggcc gcgcgcggga 1140
gagtgaggtg gggtgagctg aggggtgttg agtacccgag aactgccctg gactgtgcag 1200
<210>33
<211>1200
<212>DNA
<213>智人
<400>33
gagaagctct gagacatgtg agaaggtcta gtattctact agaactggaa gattgctctc 60
cgagttttgt tttgttattt tgtttaaaaa ataaaaagct tgaggccaag gcaattcata 120
ttggctcaca ggtatttttg ctgtgctgtg caaggaactc tgctagctca aggtgagtat 180
actgggaaag ccttaacgtt ctagagaaca gagttttgca gccccacctc catcccccgg 240
ggtgtgggac tggggggcag gaaatgcacc gtcccctttg aaatggatta ctgttttttc 300
ctttcgaccc cctctttctg cagcctgctt tgtaggtgca gtataaaatg cacgctgaat 360
gtcttttgta tgtaaacagc gtagcaggat ggagtaacgt gaaatgcaat tctacagcag 420
tttttacgtc tttgctgcct cgttcgttgg ctaccgagaa ggttcaggag ggggagggga 480
gatgagaaag cagattggaa gttgagtatg gtggagcctc agcctctccc accctccttt 540
cctcgcttgt gctcactgct aaagttttgt tactttcccc gcagcagata ctaaacatta 600
gtttgtcctg tattttcttt gagattcaca atgttgaaag cccttttcct aactatgctg 660
actctggcgc tggtcaagtc acaggacacc gaagaaacca tcacgtacac ggtaaggggt 720
gatggaattt gaaataagta cggttcagcg ggattctgtg acaaaaaaag actttacaca 780
cccctgccag tgtatttggg ctatactctg ctgagggtga taaattaaac aacacttcat 840
tcatgcttca tatctaagat tcgttgtaaa ttgccccctt gatcctttca aaagttcatt 900
gggctcacca cctaagatag gaaccaacat gtaatcattt gtgcagggct aaaaatggga 960
tccgttcaaa aactaaaacc aaagaaagtt acatgtttcc aaaacattca acaaattaat 1020
gggtgtaagg aactggaaaa cctggactcc taccacatgc agataaaacc aatacgtgca 1080
gaataagact caagtcaagt aagaacgtta aacaccataa agacacatgg ccttctttgt 1140
gtacatgaca tgcattctca agtaagtggc ctttattgaa tttataaagg ctatatattc 1200
<210>34
<211>1200
<212>DNA
<213>智人
<400>34
cggctaggtc ggagcggaga gtcgcagcag ccgctccggg cagcttccca gtcccggtct 60
gccttgtctg tgcggctgca agtccccgca cccacactta agcctttcac ttctacccca 120
ccgctcccag acgggctagg cccggttcca gggactgccc ccaaccctgc ccccgggaaa 180
tccacaactg gttccctgcc caaggccatc tcggggcgtc ctgggccctg ggcgaggtcc 240
acggcgtgtg cagggggacg gggccagcgg ggacttcctt actgctagaa agtcattcgt 300
tcagtctctg gagacagtga cggagccctg ctgcggactg gacgttgggg accaagtagg 360
tccccgctct ccaggcatct ggggagccag ggaagaagcg agtgatagag ccacaaaact 420
ccccgcaaag agtatttcag agggggaagc gccataaaga caaaacaggg caaggtggca 480
gagggtggcg gtggcaggcg cgagtctgca gctcagcccg ggcgcgctgg acgcagacac 540
gtcgactctc ctaaagaagc aaccgcaggt cagcttagac ttcttttatt tcaataaaag 600
agcgttttcc tccatcttaa accgcccgtg gtgggagaaa aggtttccaa cctcttctct 660
ggctcccctc ggtcaattcc gagcttttcc aaagtccctc cgccgtccag gggctcgacc 720
ttcgaggtaa cgtgggggat cccgctggct ccctccggca ggcgggggcg gggaccggcc 780
gtgctcgccc cctagagccc cgggagaccg cgcgccccgt ggagcccgga gggggcggaa 840
ccctggggcg ggccctgctc ggtgaaggcg gggctcggcc gccctgtctg cgccgccatt 900
ggccgcgggc cccggactgg cgggctcacg tcaccggccg ggcccgcccc cttggcaatg 960
tcttcagccc gctgctctcc taacttaagc atttattcca ctgggataga agcggcagga 1020
gcagcgttgg caccggcgaa ccatggctgg gattttctat ttcgccctat tttcgtgtct 1080
cttcgggatt tgcgacgctg tcacaggttc cagggtatac cccgcgaatg aaggtaagag 1140
cgggacggcc tttctgtggt cggggacagc gaggggccat cgcgggtgag gggtcctcag 1200
<210>35
<211>1200
<212>DNA
<213>智人
<400>35
aaccctgtgg agataggcaa aataagtata accccatttt acagttgagg ccacccactt 60
aataaacaag tgacaaagcc aagtttccag tattcctcaa gtgttttcct ttcaggctct 120
aaattgctga cttaaatgtc atcattagag agagttgtct cctcggtaga agtacaaatt 180
ttgttccaga gtcaaatatg aagacttgat cagtggcctg gcgcggtggc tcacgcctgt 240
aatctcagca ctttgggagg ccaaggcagg cggatcacct gaggtcggga gttcgtgacc 300
agcctgacca acatggagaa accccgtctc tactaaaaat acaaaattag ctgggcatgg 360
tggcacatgc ctataatccc agctactcag gaggctgagg caggagaatc gcttgaaccc 420
aggaagctgt ggtggcggtg agccaagatc gtgccattgc actccagcct gggtgacagg 480
agtgtgaaac tctgtctcaa aaaagaaaaa aagacttgat cagcttatag cctttatcat 540
ctagtcttct attctctgga gagtcagtgg ggactcttcc gagttcttgt agccttttct 600
taaggcctat aggaagtcat ctgtgctgag cctgcacttt ctataacaga tggaaaactg 660
aagctcagac atcttaagtg gcattgactt agactataga gctagttagt ggggggccag 720
caccatgacc tggcccctac ctccagcagg cttcacccac ccttgcaccc ttgcaggaag 780
cacttagagg cttgaggttg ccagctgtgg ggggttgggc ctgtgcagtg cctctcagcc 840
gcccacgctg gtggggctct gcagtgttag cttcttgttt ctctattttc tacctaggtt 900
tcagtttttc acttgggttt gtttcccctt tgtctctggt tcagcttcct tttcctgttt 960
ggttttaagt aggctataaa aatcaagttg ctgtcttcag agggtctgtg gtcctctgat 1020
caacataggc tggtgggagt acaggactcg cctcctcagg gttccctgtg ctgccacttt 1080
tcagccatgg ccacaaggtg agtattggaa ccagtgcagg ggacagaggg atgtcaagag 1140
gaaacctaga atcttaacgg tgaatgggct gtagaaatta tctcaggtcc ccttagtata 1200
<210>36
<211>1200
<212>DNA
<213>智人
<400>36
cttttaaatt tgtttctctt cccctttttg ttaaagtaca aaacaaaaca ccttccccca 60
cttttcgaat agttttggct gtgtctttag gactggaagg aaattcagct caaatgaatt 120
actatattat gaacttaagt aagaattgtt gtgcattttg tacagaatgc aactcctagg 180
agttgacaaa tgtttgttaa gtgcatcagt gagcgacata ggaccttctc ctccctactc 240
tcttgtcacg gtttttattt aatcaaacat ttattattgt tcgatgctct taaatgccat 300
ttccttcagc tgattatttg tatgacagaa gagtcaatta agctattttg tcctaaaaat 360
tacgaaaacg aaatgtacaa ttgtgaagta aaattttgtt cctttgcaaa ttttaataaa 420
ttattgaagt ttattttttg tttcaaataa tctgggcttc agttctaata atggaaggac 480
aatgtgaagg cccagaattc agcatagcgc ctggcattaa taggaggtca gtacattttt 540
agtacatgtt tctcaaatag atcttaaaat ttcatttaag agcgtttcct cacgtcacag 600
tatgtctctg gcgttactta attttgaaaa acctcaacac agattctagt tttaggcaaa 660
gctcagaaaa tttctactta aggatatttc caaagcgaaa ggaagcgcgg agacgttcat 720
gactggcatc atctcgcacg tggttccgga aattctcggt aggatgccct acatctgctc 780
tccctccact aagaagaacc tctttgtgtg gcgaaagtaa aagtattagg gcttttaagt 840
tgcccagagt caaggaacac ggataaagac gctgggagat tgacatgcat ttcgaccaat 900
agcattgcag agaggcgtat catttcgcgg atgttccaat cagtacgcag agagtcgccg 960
tctccaaggt gaaagcggaa gtagggcctt cgcgcacctc atggaatccc ttctgcagca 1020
cctggatcgc ttttccgagc ttctggcggt ctcaagcact acctacgtca gcacctggga 1080
ccccgccacc gtgcgccggg ccttgcagtg ggcgcgctac ctgcgccaca tccatcggcg 1140
ctttggtcgg catggcccca ttcgcacggc tctggagcgg cggctgcaca accagtggag 1200
<210>37
<211>1200
<212>DNA
<213>智人
<400>37
gcacaggctg ccagctcagg ctttggcccc tccatccgct cctggcttct ctgtgggtgg 60
ccccatctaa gccaatgggc ccttcctggc tccacctcct ctctgctgtg cggccctggg 120
caggcagctg ccctgccctg tgcctttgct cttggctgcc tcacccctgt cctgggctgc 180
agggagaccc ctgggggtgg gggcaggcac actttgggcc catggctgct gctcagatgt 240
gaggtggtga ccaccaggcc atacgtctct ggacagggat gggagagact cagagagaca 300
cagagaccaa gagataaagt cagagggaga tgcagagacc aagagggaca aaccaaggga 360
gacagagaga tgacattaga tcagagatgg agaccccgaa agagacccag aaagggatcg 420
gtgtgggctg ggggaagaga caccccgggg gtcacacagt ggtcacaggc atcagagctg 480
ggctgaggaa aaggacaaac tgaacctgtt ccaaagctgg gggctcagta ccgtctgccc 540
aggcacatgc agcagcagtg gggctgcagg caggccccca gggtaggaag caaggcgggt 600
gggaggcagg gcctggcctc tgggcagttt tgtagccggg cccctcaggc cctcacaatg 660
tgcccaaggc tgctgggccc atcttccagg ggtgatcact gaggctcagg ctggctgagg 720
tggccggacc ccaacccctg gccctgccct gtgggcagca gtgccaggtc tggcactcag 780
aggttaggcc gggcgcaggg agggtgcggg ctccgcagcg agcgcgccgg gcggcctcta 840
ggagccgggt cagcgagtct gggctctgag cgagcggcgc cggcccggcc ccctctccgg 900
cgggcggccg agaccccgcc ccggaggcgg aggcggagtc aggggagggg gccgggggcc 960
ggctggtccc gcctctcgcg cctccgcccc gccccgcgcg cacacagcca ggggccgccc 1020
gggctctcga cgcgccgacg gccgggcgga cggacggacg gacgccgagc gcagtgcccc 1080
gcggtgagtg cacgcggccc ctcccgcccg gactcatccc cgtcggtccg cgcctcgcag 1140
ctcaggactc gggggcgctc ggacgcaccg acggctcggc ggaccctcgg acgcgcctcg 1200
<210>38
<211>1200
<212>DNA
<213>智人
<400>38
gcacaggctg ccagctcagg ctttggcccc tccatccgct cctggcttct ctgtgggtgg 60
ccccatctaa gccaatgggc ccttcctggc tccacctcct ctctgctgtg cggccctggg 120
caggcagctg ccctgccctg tgcctttgct cttggctgcc tcacccctgt cctgggctgc 180
agggagaccc ctgggggtgg gggcaggcac actttgggcc catggctgct gctcagatgt 240
gaggtggtga ccaccaggcc atacgtctct ggacagggat gggagagact cagagagaca 300
cagagaccaa gagataaagt cagagggaga tgcagagacc aagagggaca aaccaaggga 360
gacagagaga tgacattaga tcagagatgg agaccccgaa agagacccag aaagggatcg 420
gtgtgggctg ggggaagaga caccccgggg gtcacacagt ggtcacaggc atcagagctg 480
ggctgaggaa aaggacaaac tgaacctgtt ccaaagctgg gggctcagta ccgtctgccc 540
aggcacatgc agcagcagtg gggctgcagg caggccccca gggtaggaag caaggcgggt 600
gggaggcagg gcctggcctc tgggcagttt tgtagccggg cccctcaggc cctcacaatg 660
tgcccaaggc tgctgggccc atcttccagg ggtgatcact gaggctcagg ctggctgagg 720
tggccggacc ccaacccctg gccctgccct gtgggcagca gtgccaggtc tggcactcag 780
aggttaggcc gggcgcaggg agggtgcggg ctccgcagcg agcgcgccgg gcggcctcta 840
ggagccgggt cagcgagtct gggctctgag cgagcggcgc cggcccggcc ccctctccgg 900
cgggcggccg agaccccgcc ccggaggcgg aggcggagtc aggggagggg gccgggggcc 960
ggctggtccc gcctctcgcg cctccgcccc gccccgcgcg cacacagcca ggggccgccc 1020
gggctctcga cgcgccgacg gccgggcgga cggacggacg gacgccgagc gcagtgcccc 1080
gcggtgagtg cacgcggccc ctcccgcccg gactcatccc cgtcggtccg cgcctcgcag 1140
ctcaggactc gggggcgctc ggacgcaccg acggctcggc ggaccctcgg acgcgcctcg 1200
<210>39
<211>1200
<212>DNA
<213>智人
<400>39
cccgcccctt cccccggaga cgcgcccacc cggccaccgc tctcttccca ctcccccatt 60
acccgcagcc ctcactcccc gctgcgggaa ggggctgctt ggctgcctct gggggtcttc 120
agagctaccc tggtcccggg ggattggagg aggaggttac ctatcctgcg tcgtctttaa 180
tccgtgcacc actatccatc aaatagagac agatcctggg cctctcaaag acggatgatt 240
gggggtggtg attggcctat ccctaaatat ctaccacgca aggactcttg agagatccag 300
accccggtac agtcgaggga cctggggccc aaaaagggaa agcggctacc tctaccacac 360
agttgggaag cgcagtccta aaggagacgc aggttggaga ctccgctaag cggagaagcc 420
gcagtggggc catggcaagt caccttccct ttcgggccta ggaatactca ttcgaaagat 480
ggggggactg gagtgccgag tggctgtggc agccacgatt ggggtttgga aaccatcctg 540
aaaggcccgg ggagccagtc tcctggaact tctccctccc cattcccaca aaaaccaagc 600
gccctctcgg ccaattctca ccctctcagg acaaaaaagt gagatgagcc cgtcctttca 660
cctgcgagtc caagcccttg gcagaggcct gaaaagtccg aaaactccga gttcgggcgc 720
tgaggtctcc cgagccggtt cctgaactct ccgggcctca gtcgatcggg gtgcggaggg 780
ggccgacccg ggggatctcc aagcgccctc cccgccctga cgctgtgggg ctcctaccgc 840
gccgccacag ctgctcctac ctggggaggt gcgcccgggc cccggggggc gggcagtcgg 900
ggggcgggca gggaaccggt gccgccccac gcttcgtggc ccctttaagg aggggaagcc 960
ggcggaggga ggagccggtc cggtgtgtgc aggggagcgc ctcgccagcg gtccgcaggg 1020
ctggagaccc acgccgtgga gaggaccagc ctcaggtcgc cccgcctggg cccgcgcccc 1080
gacctcgctg cccccgcctc gcctctctgc ccgtggcgct tacggccacc ttggcctcgg 1140
gggcagggca tgggcggccc ccgccagatc gcccagcgcc agtactaact gccctcgctc 1200
<210>40
<211>1200
<212>DNA
<213>智人
<400>40
ggttacctat cctgcgtcgt ctttaatccg tgcaccacta tccatcaaat agagacagat 60
cctgggcctc tcaaagacgg atgattgggg gtggtgattg gcctatccct aaatatctac 120
cacgcaagga ctcttgagag atccagaccc cggtacagtc gagggacctg gggcccaaaa 180
agggaaagcg gctacctcta ccacacagtt gggaagcgca gtcctaaagg agacgcaggt 240
tggagactcc gctaagcgga gaagccgcag tggggccatg gcaagtcacc ttccctttcg 300
ggcctaggaa tactcattcg aaagatgggg ggactggagt gccgagtggc tgtggcagcc 360
acgattgggg tttggaaacc atcctgaaag gcccggggag ccagtctcct ggaacttctc 420
cctccccatt cccacaaaaa ccaagcgccc tctcggccaa ttctcaccct ctcaggacaa 480
aaaagtgaga tgagcccgtc ctttcacctg cgagtccaag cccttggcag aggcctgaaa 540
agtccgaaaa ctccgagttc gggcgctgag gtctcccgag ccggttcctg aactctccgg 600
gcctcagtcg atcggggtgc ggagggggcc gacccggggg atctccaagc gccctccccg 660
ccctgacgct gtggggctcc taccgcgccg ccacagctgc tcctacctgg ggaggtgcgc 720
ccgggccccg gggggcgggc agtcgggggg cgggcaggga accggtgccg ccccacgctt 780
cgtggcccct ttaaggaggg gaagccggcg gagggaggag ccggtccggt gtgtgcaggg 840
gagcgcctcg ccagcggtcc gcagggctgg agacccacgc cgtggagagg accagcctca 900
ggtcgccccg cctgggcccg cgccccgacc tcgctgcccc cgcctcgcct ctctgcccgt 960
ggcgcttacg gccaccttgg cctcgggggc agggcatggg cggcccccgc cagatcgccc 1020
agcgccagta ctaactgccc tcgctctggc cttcgagccc gaagcctctt ctgcgcgcac 1080
aacctaggca gtaatcctaa actagcgggc accacagacc agctgcagcc accccaaccc 1140
agggatcact tccggacccc tcgaccgccc ggcaccagcg cgcaagggac ccttcagccg 1200
<210>41
<211>1200
<212>DNA
<213>智人
<400>41
ctgacgacta tttccagaga tcctctcccc tgccccattc cagcccagtc actctgagag 60
cgcgagggac aggccaggcc gaggcttctt cgtacagtca cacccgtttc tgggctgact 120
ttcccaaagc ctcagagcag ctctccccac cctaccccgt ccagccccct cgccgtctcg 180
cccctcccca gccccgagct agaagttcag cctcaagacg gcagcaaacg gcagagcaaa 240
ggagtcgttt tctttcacct gaaagccgcg aggaggcttg gagcgccttt cctcgctggg 300
gcccgagctt cctgggcttt ggccgggtgc gggcagaccc caccggggtc ctcgtcatct 360
cccagcccag cccgcagagc gagtaccggc agatttcaag ggcgcgtgag cctggctgtc 420
ggctgggccc ctgaggctcg ctgggcgggg gcaggccggt ccaggctgtg cggggcgttt 480
acaaaaagtg acttggagat gaactcgccc gtgcgcggct ggccgccccg ctataggggc 540
gaaggcgcct gacgcaagcg gaactcggtg gagcccatac gaatcagaac agagcgaggc 600
tcctggcgca ctagggactc caggaggcag ctccgccaga gacgcgggtc gtgcttcggg 660
aaaccggggg gcggggggag gggaagagcg cagaaaagaa aacccaccaa ggcggggact 720
ggcctgagcg gggaggggcg gcgaggccgg agcccctctc tgttgggcgg actccccatg 780
gccagaggct gagctccact cccgccggcc gctccctagg ggaaggggaa ggagagggga 840
gagcagcgac aggcctccag caagcaagcg cgggcggcat ccgcagtctc cagaagtttg 900
agacttggcc gtaagcggac tcgtgcgccc caactctttg ccgcgccagc gcctggagcg 960
gagagcagag gcggcccggc cgcggcgcgc cggctttgtc atgatggcca gctaccccga 1020
gcccgaggac gcggcggggg ccctgctggc cccagagacc ggtcgcacag tcaaggagcc 1080
agaagggccg ccgccgagcc caggcaaggg cggtgggggt ggcggcggga cagccccgga 1140
gaagccggac ccggcgcaga agcccccgta ctcgtacgtg gcgctcatcg ccatggcgat 1200
<210>42
<211>1200
<212>DNA
<213>智人
<400>42
gaaaggagct cataggaagg ggcacagcac aaggctcccg aaagaggtca ctgcaagtgt 60
cctgcgcaat ttctgttcag cacctctgca gtgacgacag gggtttgctt tcgtaagcag 120
catcgttttc actactacag aagcacatac gccgcgtgca gcttaggccc gagcaaagtc 180
cctgctcccc tagacccagt cccttcaggt gtccccctag gggaactgtg gcgtgtcccc 240
ccaaccaggc gcactcgcct aaactgcgtc cccgaactcc agggcgcagg gagccctcgc 300
gggctgcccg gggctggggc ccacacctga acggaggagc cggctggcgg agcggccccg 360
cgcgcgcaca cacgcacact cacagacacg cgcaaaccca cagcggcgcg cgcgctcccc 420
attggcggga ggaggaaggc ggggccggcc gacccaaaac aaacaacctg cgccagcgac 480
tttgccgccg cgctgcagtg tggcctccgc ctggtgcgcg cccgttgggg agctggggaa 540
ctggggagcc gccaccacct cggccacctc gttcccccac cccttgccgt ccgcgctcag 600
gccccgcccc cgcggagccg ccgcagggtt atattgggcc ggcccgaagg tggaggcgag 660
acgcagccgc ggcaggccag cggggagatg ctgccccgga ggctgggagc gggaaggcgg 720
ctgcgggcgc agcggcctcg gggactcgcc tccgcgggtg ctcaaggctg aaggcgccgg 780
accttccccc acggtggcac gcacatcatc cggcaccatt tccgtgcccc gaagacgccc 840
gcgcgggacc tgggaccgcc agtgaagaac ccctcctggg ctctttaacg agcagcagat 900
gcgcatgctg cttctctccg gcaggaaagc cttctaagcc cggcgtgctc gggcacccga 960
gggtggaacc gcggcccctg cacacactca ccccaaagtc tcaacgtcga accgaaggcg 1020
acacccaccc aactcctccc tctccgcccc atagtccacc caacacttgc agcccctcca 1080
gagaaaaagc ccagcggaag aggactccgg aaaagtgact atctcggaag accagggtag 1140
agctcccggg agaaaaaggc gaagatcccc ggccccggat cgccatcccc ttccctggca 1200
<210>43
<211>1200
<212>DNA
<213>智人
<400>43
gctcccgaaa gaggtcactg caagtgtcct gcgcaattt ctgttcagcac ctctgcagtg 60
acgacagggg tttgctttcg taagcagcat cgttttcact actacagaag cacatacgcc 120
gcgtgcagct taggcccgag caaagtccct gctcccctag acccagtccc ttcaggtgtc 180
cccctagggg aactgtggcg tgtcccccca accaggcgca ctcgcctaaa ctgcgtcccc 240
gaactccagg gcgcagggag ccctcgcggg ctgcccgggg ctggggccca cacctgaacg 300
gaggagccgg ctggcggagc ggccccgcgc gcgcacacac gcacactcac agacacgcgc 360
aaacccacag cggcgcgcgc gctccccatt ggcgggagga ggaaggcggg gccggccgac 420
ccaaaacaaa caacctgcgc cagcgacttt gccgccgcgc tgcagtgtgg cctccgcctg 480
gtgcgcgccc gttggggagc tggggaactg gggagccgcc accacctcgg ccacctcgtt 540
cccccacccc ttgccgtccg cgctcaggcc ccgcccccgc ggagccgccg cagggttata 600
ttgggccggc ccgaaggtgg aggcgagacg cagccgcggc aggccagcgg ggagatgctg 660
ccccggaggc tgggagcggg aaggcggctg cgggcgcagc ggcctcgggg actcgcctcc 720
gcgggtgctc aaggctgaag gcgccggacc ttcccccacg gtggcacgca catcatccgg 780
caccatttcc gtgccccgaa gacgcccgcg cgggacctgg gaccgccagt gaagaacccc 840
tcctgggctc tttaacgagc agcagatgcg catgctgctt ctctccggca ggaaagcctt 900
ctaagcccgg cgtgctcggg cacccgaggg tggaaccgcg gcccctgcac acactcaccc 960
caaagtctca acgtcgaacc gaaggcgaca cccacccaac tcctccctct ccgccccata 1020
gtccacccaa cacttgcagc ccctccagag aaaaagccca gcggaagagg actccggaaa 1080
agtgactatc tcggaagacc agggtagagc tcccgggaga aaaaggcgaa gatccccggc 1140
cccggatcgc catccccttc cctggcacca gcttctctag gctgcgcgaa ggaagagggt 1200
<210>44
<211>1200
<212>DNA
<213>智人
<400>44
gggactaata gatttattcc aggtgatagt gggaagcagc tacagaagga ggattggaag 60
gctgaggggt tgttaaagtt atctgatgat attgttcgaa catttctccg gcacagaaac 120
tccacaaaga actcctctgc agttttcgct acccagggct gtttctttaa attgtttgac 180
gtcagagaag gaatgctata gcaacagtct gtcaaactgg aattaactca gaagaaaaat 240
gggggtgggg agaggaaaaa tgctcccagg cggtactgac ttcagaggaa gcaaattgga 300
tagatgcatt tattttatga cattttaaac ataaaacacc cagataaatg tgaaaaaaaa 360
aaaaactcga ttgagatgca tgtggtgttt aactcatgca gagaagagcg acttggcagg 420
gatatctgga aggccttcca gttttatcaa tgacaatagg aacaataact tccaagtatt 480
ggccatttat ttggaggcag gcttcgtgca aacatcactt catttaatat gcttagcacc 540
tttatgaggc aggtatcagt atctttattt tggcgatgac gaaacttagg cccgagacgg 600
tacacggtcc tacaactagt gatggaagag cggggactgc aacgcaaggt tgtgcaactc 660
tgggcttcag tttactttct gacatttaga attccagaat gggaaaccta aatggggcct 720
ttggggtctt ctagctctgc ccttcgatcc tgctaacaag caaactggcg cctgtcagcg 780
ccggaaagga aactggccac gccacttaga cgggcgctac ttagcagcgt gccccggcgc 840
cacaccaaca agaaaacgaa actgcccggg aatgaatgtt tttcttctcc ttctggcagg 900
aaacgagaga gaaaatagga agcagaagct gcgcgcggcg cccgctccct tcgccccccg 960
cccgggctgc gcgcgctccg agggtctgcg cgtccccggc acgtccccgc cgggcccgcg 1020
cgcctcgtgc ctcgcgcctc gcgcctccag ccacgtcccc gccccggctc cggcgcgccg 1080
cggagttggc tgctgggagg tgcgggactg ggtgtggccg gcggctctgg tctcggctgt 1140
gagctgcgct ctccacgccg gctccgcgct ccaggggctg ctgagcgccc agcggacacc 1200
<210>45
<211>1200
<212>DNA
<213>智人
<400>45
gtaaccagga atgatttgac tgtataaatt tatcttacag acacacttgt ttgtacattt 60
aatgcctgct ttctataata tgaaaaaata cacagaacgt tttatgcaat tggctctgag 120
taatgcaaca cataaatgct ttgagagcag ttaccaaaaa ttatgcaggt tattacaaaa 180
gttatatgga attgcacaga tattctaaat gtgcttttga gtaaatttct cagctaccag 240
aggcctgggc agctgtttcc agcacatcct ggcacaacat tcatgttatc atccacttat 300
gtattccaca atttcaaatg attgataaga cacctccccc atctttgctt cctcttggag 360
gaaaaaaata tacaagcaat cacgagcaca ggagcaggtg gacaactaca tcttaggaaa 420
gggtgcgtaa ctgtgaactc taaacgtgag ctgggtgcct gatgcagtat aggaaccaca 480
gtaagtcgat aatcagtgag gctggaggat tgaaatttta tttggtaaag aatattgagc 540
caggcgcggt ggctcatgcc tgtaatccca gcactttggg aagccgaggc gggcagatca 600
caaggtcagg agatcgagac cagcctggcc aacatagtga aacctgcctc tactaaaaat 660
acaaaaaatt agccgggcat ggtggcgggc acctgtaatt ccagctactc aggaggctga 720
ggcaggagaa tggcttgaac ctgggaggtg gaagttgcag tgagctgaga tcgtgccatt 780
gcactccagc ctgggagaca gtgtgagact ccatctcaaa aaaaaaaaat gaatattgaa 840
atagagtcta taggaaaaaa actccttgaa tctagtaaat gtggaatcac aaaattgaaa 900
taatgtgcat ctgaaaagtg aataaataga tgccaagaag gagtgagtca taagcacatg 960
agttgtaaga ggttgaactt gagagaccag atcaggcagt gccgcttaat accatcacat 1020
gatcctcccc gaggccctgt atttaattaa aatagagagg gaggcaccac agatgccaga 1080
agaacactgt tgctcttggt ggacgggccc agaggaattc agagttaaac cttgagtgcc 1140
tgcgtccgtg agaattcagc atggaatgtc tctactattt cctgggattt ctgctcctgg 1200
<210>46
<211>1200
<212>DNA
<213>智人
<400>46
tcctacctcc ctggccactc cttttcagac tcctttgctg gtttgctctc atttttccct 60
aacctttaca tgttgatatg ccagagcacc tcaaaccctt agacctcatc tctgctactc 120
gtgctcccat ggtgatctca tctagtctct ggtttcaaac acagagtgat cactcctgta 180
cttgctgttt cccttttcct ggagttctct ctgcctcctg caggtaggaa gtgattcgag 240
ataagagagg gagagaactc ttctggccag gatagagggt gattctgaga aggcttcaag 300
gaagaagtga gcatttgagc acggctactt gaggaaggct aggccatgga cattagggtg 360
caggcaggag cagagcaaac atgcttgtaa aaggaacagc aattattctg ttttatattt 420
atatcagccc atggtggccc ccacagcaga gtggcttgat ctctcacctc cttcaggtct 480
ttgtttaaag attaacttct ccatgaggcc ttctatgaac ataaccttta aaaacataaa 540
tccccttcct actgggactc ccccagttcc caccctgaga ccccctatct ctcttctcga 600
ttttatttct ctccatagga tgtgtatcac cacctgactt actagctatt tactatatat 660
tagtttattt cttccccatt agaatgtaaa cttcctgagg gcagggattt tgtctgttga 720
gttcagttct gtatccccag cacctaaaac agtgcctgtc cataacaggc atgttaaaca 780
ttgttggaca gatgaatgag tgaatgaaaa atggtagtac ctttcctcct ccagtccatc 840
ctacacaaag aggcaagatt aatttcccta aatgcgtgag cattaggaag tgggagggat 900
tggaggagga aattataata aggaatccat aaattactta agcccataaa acaaaggtag 960
gaaacattca agataagaga cctcttctgg ccaggataga ggttggttct gagaaggctt 1020
caaggaatag gcagacattt cagcaaggct gctgaggaag gataggctgt ggaaattagg 1080
atgcaggtag gaggatcaca gagcaaacac tccaaggtgg gaaatgcaag tgtgtgtaga 1140
aggaacagca agtattgttg ggttgggctg gcttatgaag ttgtgacggg ctgagggaga 1200
<210>47
<211>1200
<212>DNA
<213>智人
<400>47
tgtgtatcac cacctgactt actagctatt tactatatat tagtttattt cttccccatt 60
agaatgtaaa cttcctgagg gcagggattt tgtctgttga gttcagttct gtatccccag 120
cacctaaaac agtgcctgtc cataacaggc atgttaaaca ttgttggaca gatgaatgag 180
tgaatgaaaa atggtagtac ctttcctcct ccagtccatc ctacacaaag aggcaagatt 240
aatttcccta aatgcgtgag cattaggaag tgggagggat tggaggagga aattataata 300
aggaatccat aaattactta agcccataaa acaaaggtag gaaacattca agataagaga 360
cctcttctgg ccaggataga ggttggttct gagaaggctt caaggaatag gcagacattt 420
cagcaaggct gctgaggaag gataggctgt ggaaattagg atgcaggtag gaggatcaca 480
gagcaaacac tccaaggtgg gaaatgcaag tgtgtgtaga aggaacagca agtattgttg 540
ggttgggctg gcttatgaag ttgtgacggg ctgagggaga gacaggactg gaaaagcacg 600
ttggggtcag gttgcagagg tccttgactg acagagaggg gagcttggtc tgtggggaat 660
cttctgctct gtgtggtcag aggctggtct gactctccgg ccttgcccca gtcttcctat 720
ccttcatcca gccccggctg gctcggtaaa aacggcgcga atctcgctct ccctgggtaa 780
ctagggtccc cactgcctgg ctagtggtgc ttttcgcgtc ttcactggca ccattaatga 840
atgaagtctg gctcccaccc gcggggaagg gaggagcctc aacctcgggt cctttgctct 900
cctgcagcac tcctgcccgg gtcccgcctc ggggtcgcca ggccctgaac cccaacgccg 960
gcattagtcg cgcctgcgca cggccctgtg gagccgcgga ggcaagggac ggagaacggg 1020
gcggaggcgg agtcagggcg cccgcgcgtg ggccccgccc ccttatgtcg ggtataaagc 1080
ccctcccgct cacagtttcc ctagtcctcg aaggctcgga agcccgtcac catgtcgtgc 1140
gagtcgtcta tggttctcgg gtactgggat attcgtgggg tgagtgccgt ctcaacggta 1200
<210>48
<211>1200
<212>DNA
<213>智人
<400>48
actgacactt tcattcatat gtttagaaga gacatatctg aagaaaattc tttttaaaat 60
agtttctcag ctgagattat acttttttag tgtgtagctc acaggaagtt ctagttgcca 120
agagcatgtt cgatatgagt agatctctac ctaattctta tgcataatga acccaatttt 180
catctcttct agaaagatac tgaaaacatg tgtcgtgatc tcaatgttac aaccatgtag 240
cctcatcttt cacaatacgg tacaatcacc aacgaagttt aaacttcatg tctggcatcc 300
aaggtgaaca tttccataga aagtaggaaa tatttagatg tctgtttgcc gtggtggtgg 360
tgttcctata tactttttgt gaccctaaag atataataat gtttgacatt tttgttagcc 420
agtaatgtgg acttaagaca tcctaaccac actgctgact ctaacccttt aatagacttt 480
cacgtagttc ttgagcctca ctgcaggctc cagtgctagt cccggaggaa atcagaaaag 540
ggttgaaacc actgacacag ccatctcttt agctcctcct aacgcaggtg tacagtttcc 600
tgtagtgagc agatcggggc ctacagggac actgcatgct tgcactgggc tgttactagt 660
ttcatggaaa tatgtactaa ttgtgtcact gtgttttctt gtcacactgc cccctttcta 720
ggccgctctg gcaccgttta tttaaactgt gcaaccatct ggcccaggtg ccgtagagat 780
tgatcagtag cacaaggcca ccacaagcac aaccgccacc cggccatccc agctatttcc 840
tccagcattc tagacatcat ggcgtccgag ggtgggtcca acgggcttcg agtgttcggg 900
agataatgca cacttcgcag tggatcttct cggggccccg agcgttgccc gcccattagg 960
tggcgccggt cccctcgaac aggtcgctca acaactcccg cccagcagcc gcccttactg 1020
cgcgcgcgca gacttcggcg tctacttccg gtgtggccca ggcggggtcc gcagaaccag 1080
ctatgtcggc ctacggcatg cccatgtaca agagcgggga cctggtgttt gccaagttaa 1140
agggctatgc ccactggccg gcgaggatag agcacatgac ccagcccaac cgctaccagg 1200
<210>49
<211>1200
<212>DNA
<213>智人
<400>49
tttttagtgt gtagctcaca ggaagttcta gttgccaaga gcatgttcga tatgagtaga 60
tctctaccta attcttatgc ataatgaacc caattttcat ctcttctaga aagatactga 120
aaacatgtgt cgtgatctca atgttacaac catgtagcct catctttcac aatacggtac 180
aatcaccaac gaagtttaaa cttcatgtct ggcatccaag gtgaacattt ccatagaaag 240
taggaaatat ttagatgtct gtttgccgtg gtggtggtgt tcctatatac tttttgtgac 300
cctaaagata taataatgtt tgacattttt gttagccagt aatgtggact taagacatcc 360
taaccacact gctgactcta accctttaat agactttcac gtagttcttg agcctcactg 420
caggctccag tgctagtccc ggaggaaatc agaaaagggt tgaaaccact gacacagcca 480
tctctttagc tcctcctaac gcaggtgtac agtttcctgt agtgagcaga tcggggccta 540
cagggacact gcatgcttgc actgggctgt tactagtttc atggaaatat gtactaattg 600
tgtcactgtg ttttcttgtc acactgcccc ctttctaggc cgctctggca ccgtttattt 660
aaactgtgca accatctggc ccaggtgccg tagagattga tcagtagcac aaggccacca 720
caagcacaac cgccacccgg ccatcccagc tatttcctcc agcattctag acatcatggc 780
gtccgagggt gggtccaacg ggcttcgagt gttcgggaga taatgcacac ttcgcagtgg 840
atcttctcgg ggccccgagc gttgcccgcc cattaggtgg cgccggtccc ctcgaacagg 900
tcgctcaaca actcccgccc agcagccgcc cttactgcgc gcgcgcagac ttcggcgtct 960
acttccggtg tggcccaggc ggggtccgca gaaccagcta tgtcggccta cggcatgccc 1020
atgtacaaga gcggggacct ggtgtttgcc aagttaaagg gctatgccca ctggccggcg 1080
aggatagagc acatgaccca gcccaaccgc taccaggtgt ttttcttcgg gacccacgag 1140
acggccttcc tgagtcccaa acgcctgttc ccgtacaagg agtgcaagga gaagttcggc 1200
<210>50
<211>1200
<212>DNA
<213>智人
<400>50
aaaggcaaat tatgtgcaca tgaccctgtc actacaaggt agttctcgac caagctacat 60
cttatagctt tatcttatat tcctctccca tcatctgcag gaaaagggat aggtgctgag 120
ggaaaacccc taagtagaac tcacagtaag cagtgggaaa acagcttatt tcactaacgg 180
ggttaagtgg ccctgaaaag agcctttgga gacaaagcag ccggcgaccc gcggagggag 240
ggagggaggg agcgagcgag cgccaggtcc cggcagggac tcacttggag ctggcgtact 300
tggtgaccgc cttggtgccc tcggacacgg cgtgcttggc cagctcgccg ggcagcagca 360
ggcgcacggc cgtctggatc tccgggacgt gatggtggag cgcttgttgt agtgcgccag 420
gcgggacgcc tctcccgcga tgcgctcgaa gatgtcgttg aggaaggagt tcatgatgcc 480
catggccttg caccagatgc cggtgtcggg gtggacccgc ttcagcacct tgtacacgta 540
gatggagtag ctctccttgc ggctgcgctt gcgcttcttg ccgtctttct tctgggcttt 600
ggtgacggct ttcttggagc ccttcttggg agccggcgcg aactttgcag gctcaggcat 660
ggccagaccc aagaccgaca ccgacccccg agaacgcaag cagagcggta ggctcggggt 720
ctaccggaaa cgactgtgta cttacagagg ctgtgcgcat gacgctgcgt tatggttcgc 780
gagttttccg cggcgcgcaa tgcgagggag acgagattat gtaaatgagt ggattctggc 840
tgagctatcc tattggctat cgggacaaaa tttgcttgag ccaatcaaag tgctccgtgg 900
acaatcgccg ttctgtctat aaaaaggtga agcagcggcg ttttcggcga ctttcccgat 960
cgccaggcag gagtttctct cggtgactac tatcgctgtc atgtctggtc gtggcaagca 1020
aggaggcaag gcccgcgcca aggccaagtc gcgctcgtcc cgcgctggcc ttcagttccc 1080
ggtagggcga gtgcatcgct tgctgcgcaa aggcaactac gcggagcgag tgggggccgg 1140
cgcgcccgtc tacatggctg cggtcctcga gtatctgacc gccgagatcc tggagctggc 1200
<210>51
<211>1200
<212>DNA
<213>智人
<400>51
ctatataaac caaaaattgc ttcaaccaca gaatggaggt ctacaggtgc ggaaggaaag 60
tttatatggt gaggcttggt cgcaaaacta ttaggaatat tttcaggtta ctacacaatt 120
ttgcgagctc aatatgcagt taacactttt tccctcgact ctcctgagca gatttacatt 180
gaccgcaccc gtagcatatc gtctcacttt ggaaaaggca aattatgtgc acatgaccct 240
gtcactacaa ggtagttctc gaccaagcta catcttatag ctttatctta tattcctctc 300
ccatcatctg caggaaaagg gataggtgct gagggaaaac ccctaagtag aactcacagt 360
aagcagtggg aaaacagctt atttcactaa cggggttaag tggccctgaa aagagccttt 420
ggagacaaag cagccggcga cccgcggagg gagggaggga gggagcgagc gagcgccagg 480
tcccggcagg gactcacttg gagctggcgt acttggtgac cgccttggtg ccctcggaca 540
cggcgtgctt ggccagctcg ccgggcagca gcaggcgcac ggccgtctgg atctccggga 600
cgtgatggtg gagcgcttgt tgtagtgcgc caggcgggac gcctctcccg cgatgcgctc 660
gaagatgtcg ttgaggaagg agttcatgat gcccatggcc ttgcaccaga tgccggtgtc 720
ggggtggacc cgcttcagca ccttgtacac gtagatggag tagctctcct tgcggctgcg 780
cttgcgcttc ttgccgtctt tcttctgggc tttggtgacg gctttcttgg agcccttctt 840
gggagccggc gcgaactttg caggctcagg catggccaga cccaagaccg acaccgaccc 900
ccgagaacgc aagcagagcg gtaggctcgg ggtctaccgg aaacgactgt gtacttacag 960
aggctgtgcg catgacgctg cgttatggtt cgcgagtttt ccgcggcgcg caatgcgagg 1020
gagacgagat tatgtaaatg agtggattct ggctgagcta tcctattggc tatcgggaca 1080
aaatttgctt gagccaatca aagtgctccg tggacaatcg ccgttctgtc tataaaaagg 1140
tgaagcagcg gcgttttcgg cgactttccc gatcgccagg caggagtttc tctcggtgac 1200
<210>52
<211>1200
<212>DNA
<213>智人
<400>52
gatggagcag aagctctaat tgcttcgagg tacaagtcca tctaaacctc tgagatctca 60
cccgtccccg gtaagccctt gcgccctcca gacaagctcc tcagtgaaag caagcgccgc 120
accggtgcct gtgccagtct cccagaaagg agcataagga gtgttccacc accactctgg 180
attctttatt ccaacaaccc agccggaggg gaaaatctgc taaaccaccc cacaaggcag 240
aaactttatc aaaatctggc actacaacac tggccctcat cacgccgcca caaattgcga 300
gggatagaag aaagctgcaa agtcacgtta aaaggaagcc tagtcaaaaa gtgaaaattt 360
tgtcccgccc taggcacaca gcactcacag cataagatgt agttccatga gtcctaggaa 420
agggggaaga aaggaaaaaa ccaaacatct gctctaggtt tagaagaggg ataacatcag 480
cgccaagcaa accgaaagcg cagaggactc agaagagggg aagaggaata actttatctg 540
tcctggaggt gggcgaagag cagtctccac cggccgcgcg tcacgctccc atttaacctt 600
ttccatgccg cgacgcccac actccgccct cgagggacta gcccccccca cgatccagag 660
cagaagcggc tcgccccgct gcatccacgg gccctcaccc aagcgtccag tcctgccttt 720
ctccccccac ctcgcccaat acctgtccga gagcaggcgt tctgccctct cgccccgccc 780
ttgcccaggc agcccccggt cgcgacggct ctcctcgggg ctcgggggcg ctgggcggcg 840
gccctgggct gctttggcta acttggctgc ggggcaggcg cgaggagcgg cgcgccgacc 900
gggccgagcg gagaggccgc ccattggccg gccagcgcca cgtggccgcc cccgccggta 960
tattaggcca ctatttacct ccggctcact cgccatgggt tggagagggc agctcgggta 1020
gagagggctg gcggagcggc gcagacggcg gcagtcctgc tcagcctctg cccggctccg 1080
tactccggcc ccggcctgcg ccctcagaaa ggtggggccc gaaccatgag ctcctacctg 1140
gagtacgtgt catgcagcag cagcggcggg gtcggcggcg acgtgctcag cttggcaccc 1200
<210>53
<211>1200
<212>DNA
<213>智人
<400>53
gcctgtgcca gtctcccaga aaggagcata aggagtgttc caccaccact ctggattctt 60
tattccaaca acccagccgg aggggaaaat ctgctaaacc accccacaag gcagaaactt 120
tatcaaaatc tggcactaca acactggccc tcatcacgcc gccacaaatt gcgagggata 180
gaagaaagct gcaaagtcac gttaaaagga agcctagtca aaaagtgaaa attttgtccc 240
gccctaggca cacagcactc acagcataag atgtagttcc atgagtccta ggaaaggggg 300
aagaaaggaa aaaaccaaac atctgctcta ggtttagaag agggataaca tcagcgccaa 360
gcaaaccgaa agcgcagagg actcagaaga ggggaagagg aataacttta tctgtcctgg 420
aggtgggcga agagcagtct ccaccggccg cgcgtcacgc tcccatttaa ccttttccat 480
gccgcgacgc ccacactccg ccctcgaggg actagccccc cccacgatcc agagcagaag 540
cggctcgccc cgctgcatcc acgggccctc acccaagcgt ccagtcctgc ctttctcccc 600
ccacctcgcc caatacctgt ccgagagcag gcgttctgcc ctctcgcccc gcccttgccc 660
aggcagcccc cggtcgcgac ggctctcctc ggggctcggg ggcgctgggc ggcggccctg 720
ggctgctttg gctaacttgg ctgcggggca ggcgcgagga gcggcgcgcc gaccgggccg 780
agcggagagg ccgcccattg gccggccagc gccacgtggc cgcccccgcc ggtatattag 840
gccactattt acctccggct cactcgccat gggttggaga gggcagctcg ggtagagagg 900
gctggcggag cggcgcagac ggcggcagtc ctgctcagcc tctgcccggc tccgtactcc 960
ggccccggcc tgcgccctca gaaaggtggg gcccgaacca tgagctccta cctggagtac 1020
gtgtcatgca gcagcagcgg cggggtcggc ggcgacgtgc tcagcttggc acccaagttc 1080
tgccgctccg acgcccggcc cgtggctctg cagcccgcct tccctctggg caacggcgac 1140
ggcgccttcg tcagctgtct gcccctggcc gccgcccgac cctcgccttc gcccccggcc 1200
<210>54
<211>1200
<212>DNA
<213>智人
<400>54
aacagtgtga aaagtcacat gataaactgg ggaagatatt tacagtacat gtaatggaca 60
gagggttaat gttcttgcta gatatcttaa aatcaagaaa aataaactca gtaaaaagat 120
gcaaagggca taagatggaa ttcacacaca gtgcaagttg aatttttttt tttttttttt 180
gcctgccaga gtgctacagg taaaacagat tgctactacc cagtgttgct ggtgggctag 240
agtgttcatg tagctttctg caggccagtc tgagaatatt tattaggatt ttaaaagtgc 300
attcattgac cagcacttca cttctgaatt taatgcaagg aaatagttgg gtaaatgggc 360
aaaactattt tgtacaaaaa tattcattgt gttcataata gcaaaaaatt ggaaatcatc 420
caaatgtcat ttgtgttata actccataca ctggaaaagt gagcagccat gaagatggtg 480
tagatttgtt tcaccagcat ggaaaggtgc ctgttacata tttaagtgtg aagatgaggt 540
tgtaaaatgt atgcctggta tgctatgatt tcataagaca cgtggaacta tatcttctta 600
tatgccgatt gatgaagatg gaatcagtgt atataccaaa gagattaaaa gtggttcttt 660
atctgagtga tgattttgtc ttcattgtgt ttagaatact aagaagtttc agcagtggaa 720
tgcctactct tcttataacc ggagtggaaa cggaagcatt ttgtgagagg gctggaggga 780
aggtgagaac gggcgttggg aggcccttcc gtggctccag gcctagggct gcggaaccca 840
caacagaacc cgcaaccgca accgggaacc cgagtgcctg cctagctggg gggccggagg 900
gagggcgggg agggcagcgc cacggacccc agcggaccgg aagggcttgt ggcacgcgga 960
atccccctca gaggccccca gctgccttcc ctgtggcatc atgaagtttc gcgccaagat 1020
caccggcaaa ggctgtctag agctgttcat tcacgtcagc ggcaccgtcg cgaggctagc 1080
gaaggtctgc gtgctccgcg tgcgccctga cagcctgtgc ttcggccccg cgggttccgg 1140
cggcctccac gaggccaggc tgtggtgcga ggtgcggcag ggggccttcc agcagtttcg 1200
<210>55
<211>1200
<212>DNA
<213>智人
<400>55
ggccaagcaa acacccgctc atatttagtg catgagcctg ggttcgagtt gccggagcct 60
cgcgcgtagg gcaggggttc gagcgcccct tctccctgcc tcgcctctgc gcctgggggc 120
tgctgcctca gtttcccagc gacaggcagg gatttcgagc gtccccctcc cctccctcgt 180
caagatccaa gctagctgcc tcagtttccc cgcggagcct gggacgccag cggaggggct 240
cggcgcgtag ggatcacgca gcttccttcc tttttctggg agctgtaaag acgcctccgc 300
ggccaaggcc gaaaggggaa gcgaggaggc cgccggggtg agtgccctcg ggtgtagaga 360
gaggacgccg atttccccgg acgtggtgag accgcgcttc gtcactccca cggttagcgg 420
tcgccgggag gtgcctggct ctgctctggc cgcttctcga gaaatgcccg tgtcagctag 480
gtgtggacgt gacctagggg gaggggcatc cctcagtgga gggagcccgg ggaggattcc 540
tgggccccca cccaggcagg gggctcatcc actcgattaa agaggcctgc gtaagctgga 600
gagggaggac ttgagttcgg accccctcgc agcctggagt ctcagtttac cgctttgtga 660
aatggacaca ataacagtct ccactctccg gggaagttgg cagtatttaa aagtacttaa 720
taaaccgctt agcgcggtgt agaccgtgat tcaagcttag cctggccggg aaacgggagg 780
cgtggaggcc gggagcagcc cccggggtca tcgccctgcc accgccgccc gattgcttta 840
gcttggaaat tccggagctg aagcggccag cgagggagga tgaccctctc ggcccgggca 900
ccctgtcagt ccggaaataa ctgcagcatt tgttccggag gggaaggcgc gaggtttccg 960
ggaaagcagc accgcccctt ggcccccagg tggctagcgc tataaaggat cacgcgcccc 1020
agtcgacgct gagctcctct gctactcaga gttgcaacct cagcctcgct atggctccca 1080
gcagcccccg gcccgcgctg cccgcactcc tggtcctgct cggggctctg ttcccaggtg 1140
agtcggggtg gggattgccg tcgggccagt tctccgaagc cccgggagga ccggctcccg 1200
<210>56
<211>1200
<212>DNA
<213>智人
<400>56
gggagggtcc cacggacata ttgagggacg tggatacgca gaagaggtat ccatgtggtg 60
gcagccggga aggggtgatc agatggtcca cagggaatat cacaaactcg aattctgacg 120
atgttctggt agtcacccag ccagatgagc gcatggagtt gggggtgggg ggtgtcaaag 180
cttggggccc ggaagcggag tcaaaagcat caccctcggt cccttgttct cgcgtggatg 240
tcagggcccc cacccaccga gcagaaggcg gactcagggg cgctccaggg tggctcgagc 300
tcacacacgc tgagtagaca cgtgcccgct gcaccctggg taaatacaga cccggagccg 360
agcggattct aatttagacg cccgcgaacg ctgcgcgcac gcacacgtgt cctcggctcg 420
ctggcacttt cgtcccgccc cctccgtcgc gtgcgggagc tgacccggag gggtgcttag 480
aggtatggct ccgcggggtc aaaaggagaa ggatcagtga gagaggcatc cccacaccct 540
cccctagaac tgtcctttcc ccatccagtg cctcccaaat ctctcttagt ccccaaatgt 600
atccccgccc taaggggcgc tggtgggagg agctaaatgt gggggcgggg ctcggagtcc 660
agcttattat catggcatct cagccagggc tggggtaggg gtttgggaag ggcaacccag 720
catcccccga tcccagagtc gcggccgggg atgacgcgag agagcgtggt cgcccccaga 780
aggccctggg ccatcatgcc ggcctccacg tagaccccag gggtcgctca ctcctgccag 840
ctcgccttca ccaaggccag gagcttagcg cacgctcgcc tcccgccccc ccgccgcctc 900
tgccgccgcc ccctccttgg aaaccaagtt accaacgtta aaccaatccc caagcgcaac 960
tctgcctccc ccacacccca cccgccgcgc cgcgcggagc cgtcctctag cccagctcct 1020
cggctcgcgc tctcctcgcc tcctgtgctt tccccgccgc ggcgatgcca gggccttcgc 1080
cagggctgcg ccgggcgcta ctcggcctct gggctgctct gggcctgggg ctcttcggcc 1140
tctcaggtaa gagccccgct ctggttcggg gtggacaggg cgggggcgga gtccctggac 1200
<210>57
<211>1200
<212>DNA
<213>智人
<400>57
ggaaagggga tcggggagga aagtcgggga ggcgaggtgg gggcggtggg ctgagcggga 60
acttaaaaga ccgcggtgga gaagatgggg cgttctccgc gacactcggc tgcccagagg 120
tgcaaagccg gtgggcgcac gcccggggcg gccctacagc cctcgggccg ccagtctcag 180
ggtgtcgggc tccaactaag gccccgaagc ccccacgcac ctgagggcat tttgaccagc 240
tcttgcgggc tgtcttgcgg ccgcagtggg ttctgaaagt ccattccggc gtagggtgga 300
aaccggcggg aggcgttgct gattctcgat taaacaatag tgacgagacg cgtgcggggc 360
gcctgcgagc cccttcctgc cactcggagc agagcgcgcc agcgcgaggc cgggccggcc 420
gcctgcgcag cgccgggcta attttaactg ttgattacat cttcagcgtg tcctttcata 480
ggtctcattt gtaattgaga cgaatgatta cagtggggcg ggaaggagca gctgctcatt 540
aattaatttc taattaaaag tgcctctcgt tctcgggtga ctaaagagaa acaccgttcg 600
ctgggcgata ttgactcgga tggaatttat ttgctaacgc ccggaggaat ggcccctccg 660
tccaccgcgc ggccgggact gtcctggccc ctcccggcct gagccgccgg cgagtgaccg 720
gcgagtctgc ggccaggccg ggctgcgcga ggtggggctg acgtcagagc ctcctccgct 780
tcaagccgcg cacatctgac ttgacgggtt cgcgcgactc gttttttttt ttttcttttt 840
cgtaaaatat gtatttctgt cgccgctgcg aggccgctcg gtcccagagc cccctcgagc 900
ctccggaatg cgaagttaaa ggaatcgcgg cggccaccgc tgctcacttt gttacccggt 960
tagaaaagtt tgcggagcgc ggggatggac taaccggctc tcctgcttcg ccctcccagc 1020
gcctagaagc ctgcagctcc ggagcagtgg ccgcgccacg ccggccccag cgcgcagaac 1080
cctgcaggcc ccgcccgtcc gccccgggcc gcgcccgcca tgtcctaccc gcagtttgga 1140
tacccctact cctcggctcc ccaggtaagc ggagccccgc cccgcccagg ccaccgcagg 1200
<210>58
<211>1200
<212>DNA
<213>智人
<400>58
gaatcatagt aggtaattga gttatttttt aatttttatt ctgtctttat aagatttttg 60
agaaggtaat caattaacat aaagatctga gcagttataa agatttacaa agaagattat 120
acagtgatgg aaactgaagc atattcttgg caacaatctc aatctatttc acgtttcccg 180
gcttttacat atataaattt ggtatacata atatgtaaat atacttctat tttgcatgaa 240
aactaaaaat actaaaaaag tagcatgagt atatgaaaaa gttaaacatt aaaaatatta 300
gttggaaact ggcttatttt actaacaatt atattcagaa ttctgttgct agactgctgt 360
ttctgggaac attggaggtg tactttctat acttgctaaa atacaagctt ttcaagtatt 420
ttccatagta ttaagtgaga ctttaaatac tcttgctttt ttagatctaa tttctgcttt 480
aatttatcct tctcttcatt tttcctgttt gtcctcatct tacctgttct tccctggttt 540
tactatctcc cagtattcag aaatcagagc aaataattag tctgcttttc tgcagaataa 600
actattgggt atgccatcat gcttttgatc taccacataa acaaattatt ttagcaagac 660
atcactttta tatgctgtat aatgtatgta ttgcttatgt tttaagcaga tttcagctct 720
tttccttcca tcaatttgga attgggggcc caaaagatgt gaaggcgata atgcttccaa 780
gataactggg ctgcatcctt atttgtaaaa taagaaatac tttatttccc aaattttaaa 840
ggagtgttcc ttctccgacc tgttgtgatg gatttattct atagctatgg aaatataccc 900
tgcttcactc ttgtacatac ttctttactc tcctcccgcc aagttcattg aaagagaacc 960
catgtgccgg tccagagcat cgctgcatcc gtaagcagct agacctcagc ttcctctgtc 1020
accatggtgc cggctcggct gggcccggcg gtcgccatgg taactggggc gggtcgcagg 1080
gtcctggcag gctgggcgca tgcgcgcggg gactacaagc cgcgccgcgc tgccgctggc 1140
ccctcagcaa ccctcgacat ggcgctgagg cggccaccgc gactccggct ctgcgctcgg 1200
<210>59
<211>1200
<212>DNA
<213>智人
<400>59
taggggagag ggactcgcca aatccctgtt ttctggggta agcccccctc cccccactct 60
tggacccaag ctgcccggaa ggaagaagga agcattgttt gtcaccggag aaaaccacct 120
gtggtttgca aagggcctca gtcgagtcag gggcaggcgg ggcagatccg agcccggcgg 180
gaggggcgag gcgcgggggc gggcaggggc gagggtaggg gcgctcagct ggcaggtcct 240
gctctgcagg cctcaccgcc cagctcccgg gagggggccg agggcgccct gagtgctgcg 300
cgccttccca tgacgcagtt cctgtgcctt taaatcccac tcccggaggg ggcgggggcg 360
ccccggctgg accccggttt ccagtccggc gggggccccg gggaagccca gggcggggag 420
cgcggggctg ggggcgcgga gggcggggcg cccggggtcc ccgcccgcgc gccgcgccct 480
agcctgctgg gccgcgcccc tcttgggacc gccgcgctcc gggggcgggg gcgggggcgg 540
gggcgggggg cggggggcgg ggggcgggcg ggggcgcgcg ggcgggcggg gtgcgggcgc 600
gcgccgcgcg gcccgagcgc gcgagccggg cccggagcgc acgccgccgc cgccaccgcc 660
gccgccgccg cccgagccgc cgcattgctg ctgctgctgc cgccgccgcc ccgcgcccgg 720
cccgcggccc ccaatatggt gcagccgcca gcgccgccgc ccgtgccgcc gccgccgccc 780
gcgggccccg ccgccgccct cgggcgcccg cagcgcggca gccgcaggtg gggggccgcg 840
gcccgggcct gagctgcccc ccgcccggcc tcggcgcggc gccctccccg cggggctgcc 900
ggcgaggggc cctctcgccg ctgaggtgga gccgcgggcc ccgccgccgc cgctcctgcc 960
ccctccctcc ctcctcccct ccccctcccc tccggtcctg tctccagcgg gagcgcgaga 1020
cgctggtcag gctccgcggc gcagctcgaa aaggaataat cgcccccgat tgactgaaat 1080
tcctccggag ccggcgccgc ggccgcccgc gcccgagacc gcgctccggg gccgcgtcct 1140
cctctcctcc ggaaaacgct cgcgacccag ggccgccggc ggccgcgact ctgctgtgtc 1200
<210>60
<211>1200
<212>DNA
<213>智人
<400>60
ctttctcttt catcttcctc cctctgccag agccagggag ggagagtggg aggcgtcaag 60
gaggtagggg agagactggc agaggaaaag gagtgggtgg gtgggggcca agtaaataga 120
tacttagatg atgaagtcaa gccactgcgg caatgtttct tgtcagtttc acgcgggcaa 180
agcgtgcctt tcggtgggtt ataagcagcg cccggtccttcctt ctctcg ccaagttgcc 240
tgatccttcc ctccaggcgc gcgcgcacac accacactca cacaccccaa aaccaagact 300
cgtcctacag gatctgggaa aagaaaaaga aaaaaaagcc ctcaatcacc acctccttct 360
cgccgactcc ccctcacccc ccgcctcccc tccagcgggc agccaaggag agctagaggc 420
gggggagggg agagggagga gaagcgacgc aagtgggtag cttttcagcg ccggcgaggc 480
gcgggaggag gagaagcagt ggggaggcgc agccgctcac ctgcggggca gggcgcggag 540
gagggacccg ggctgcgcgc tctcgggccg aggaaccagg acgcgcccgg agcctcgcac 600
gcggccaagc tcggggcgtc ccctcccctc ggccgggcga actcaagggg cgcagctctt 660
tgctttgaca gagctggccg gcggaggcgt gcagagcggc gagccggcga gccaggctga 720
gaaactcgag ccgggaacaa agaggggtcg gactgagtgt gtgtgtcggc tcgagctccg 780
ggcagaggca tttgggcccg aggcccccgc tgtgactccc cgagactccg cagtgccctc 840
cactgcggag tccccgcgct tgccggcaaa aactttattc ttggcaaact tctctttctc 900
ttcccctcct cctcggcccc catcttctgc tcctcctcct tctctagcag attaaatgag 960
cctcgagaag aaaaaccgaa gcgaaaggga agaaaataag aagatctaaa acggacatct 1020
ccagcgtggg tggctccttt ttctttttct ttttttccca cccttcagga agtggacgtt 1080
tcgttatctt ctgatccttg caccttcttt tggggcaaac ggggcccttc tgcccagatc 1140
ccctctcttt tctcggaaaa caaactacta agtcggcatc cggggtaact acagtggaga 1200
<210>61
<211>1200
<212>DNA
<213>智人
<400>61
aatgagaccc agagggtcgg tcctaggaca caattcctct caccctctgc ttctgccacc 60
atcctttccc ctttgccctt ggaggtgctg gaggaggtgg gagtgtcccc gagagtgtcc 120
agactgcata aggtggcaga aaggtgctga gtgtcttcca ttgcaccagt gtcagggact 180
tggatgtggt ccccaggccc aaagccaagg cagatggact catggagggg gaggagcaga 240
ggagcagtgc ggagtcactc tctccatgta gcacccccag ctcagtgcat tgctggggtt 300
cttgcagggc agatgaagtg cttctttgta taggggaata tgtgggtgaa ccaggaaaat 360
gggagcctag tacatggagg tttattccaa ctccctgtgt gattggcaag ttagaattgc 420
ccccctacct gagttattat tggctcctga gaaacaggcc aaaggcagcc cccactaaga 480
agcttttagc acctcctata ggaaggaagc cttcccagtg aatccagtgt gaggattctt 540
ttctccaggt ctctggacct ctcccaacat gctccatgtt cctttgcacg aagaagaaca 600
gcgcagttcg gtagagtgta tgtaagcccc ggttgccatc agcacactgt gtggattctg 660
gcaatacctg tcatccccac tggtgctgcg gtgcccctca tgccccttgt taataaccaa 720
tgatagtgcc acttgaactc ccaggctgtt gtgaggagca agcattcatt cattcattca 780
ttcaatcact catttgttca tgtgacaaat gtggattgaa tgcttgccct ctttcctctc 840
ccctggagcc ttggagagag agataagaca agcgcaaata actgtgacct gttgtaggaa 900
gtgagaaata cacccaggca gggccagata ctgcgtagca ggcggggcac agaggaggga 960
acgcttgtgt ctaactgatg ctcctaatgc ggaagcccct gaaaggcggt tgtggtgcaa 1020
aggaaaaccc acaggccaag gaatgggaag accaaggttg acacttgttt gtcaagtgtc 1080
aataatcatc tctgcccggt gagttgttgc atgaagcaag atcctccttg gggggtgttt 1140
agcacagagg gggtgcgatt ttatttcctg tgaaaatacc aggtagtatt atgttcacta 1200
<210>62
<211>1200
<212>DNA
<213>智人
<400>62
catttcacct atttgactct gcctgcctag agcttgccga gaatgagacc cagagggtcg 60
gtcctaggac acaattcctc tcaccctctg cttctgccac catcctttcc cctttgccct 120
tggaggtgct ggaggaggtg ggagtgtccc cgagagtgtc cagactgcat aaggtggcag 180
aaaggtgctg agtgtcttcc attgcaccag tgtcagggac ttggatgtgg tccccaggcc 240
caaagccaag gcagatggac tcatggaggg ggaggagcag aggagcagtg cggagtcact 300
ctctccatgt agcaccccca gctcagtgca ttgctggggt tcttgcaggg cagatgaagt 360
gcttctttgt ataggggaat atgtgggtga accaggaaaa tgggagccta gtacatggag 420
gtttattcca actccctgtg tgattggcaa gttagaattg cccccctacc tgagttatta 480
ttggctcctg agaaacaggc caaaggcagc ccccactaag aagcttttag cacctcctat 540
aggaaggaag ccttcccagt gaatccagtg tgaggattct tttctccagg tctctggacc 600
tctcccaaca tgctccatgt tcctttgcac gaagaagaac agcgcagttc ggtagagtgt 660
atgtaagccc cggttgccat cagcacactg tgtggattct ggcaatacct gtcatcccca 720
ctggtgctgc ggtgcccctc atgccccttg ttaataacca atgatagtgc cacttgaact 780
cccaggctgt tgtgaggagc aagcattcat tcattcattc attcaatcac tcatttgttc 840
atgtgacaaa tgtggattga atgcttgccc tctttcctct cccctggagc cttggagaga 900
gagataagac aagcgcaaat aactgtgacc tgttgtagga agtgagaaat acacccaggc 960
agggccagat actgcgtagc aggcggggca cagaggaggg aacgcttgtg tctaactgat 1020
gctcctaatg cggaagcccc tgaaaggcgg ttgtggtgca aaggaaaacc cacaggccaa 1080
ggaatgggaa gaccaaggtt gacacttgtt tgtcaagtgt caataatcat ctctgcccgg 1140
tgagttgttg catgaagcaa gatcctcctt ggggggtgtt tagcacagag ggggtgcgat 1200
<210>63
<211>1200
<212>DNA
<213>智人
<400>63
ccaccatgcc ctttgctctc cagggctctg gggccggccc aggtcagcca cttggtggga 60
ttccagcctc agggtggctg agctgcaggt gcagcacccg gcctccaggt ggcaccaatc 120
cgcttacttt gaggtgggct ctgacaacca gctgagctgc ccacagtccc tcagactccc 180
gaggtcctgg gagcagggat caaggtggtc cccaggccgt aaacctgaca gaggctgcag 240
gagtgcattt ccacccaggg tgcactcagc gggtgtaact ccacacccgt ttctttggag 300
tcaaggcccg gcctctcagt gaggagactg ctcctggttg cccaccgtcg ggtcatccca 360
gcctgcagtg gaaccctccg cagcctggcc tcttccaggg tagcccctca ctcccctctc 420
tcctgtccta gcagacaggc cagggagggt ggacgagttc cagctctggg gatgtcccat 480
cagctgtgtc accttgaaca aatcattttg cctcttgggt ctcagtttcc tgcagtgtga 540
aacgtggtgg aggcatgagg ggcaatggga gccccaaggc ctctttcaga gacctcctct 600
gggtcccatg tgacctcgtg gctgtcccca aaggcaagag ggtccccagc cctgcggcca 660
aggccctggg acaccctatc caaacaaatg caggtctctg acgggctgag ctttgctcgc 720
ttgggtttct ttgctttctt cctttttttt ttttctttcc tggatgaaat tcctgccagc 780
tccgaaggaa ggagggaaga ggagcgagcc gcagtgtaga aagtttcctt gactcctcct 840
ccggctgggt ctccctccct tgccaagccc agcctgtgaa actgaataac gaagatcact 900
caacaatgcc tgcccctctc tgactgcacc gtcccggcgc tcccaccgcc gccgccgccg 960
cccaatagag cccctggggc ggtccccacc gacggtgcag cccgccggga ccgggaggaa 1020
gcagctgcgg ccatcgcgcc gtgcgtccgc gcccggccgc caggtgcccc agtagcccga 1080
ccgccgagat gcccagcccg ccggggctcc gggcgctatg gctttgcgcc gcgctgtgcg 1140
cttcccggag ggccggcggc gccccccagc ccggcccggg gcccaccgcc tgcccggccc 1200
<210>64
<211>1200
<212>DNA
<213>智人
<400>64
gctgaagtca cctttccagc agtgtctggt ccagccaggg catcatgccc agtaacagcc 60
ccgatgtcca acacttcccc atgtcctctt ctccccctag acactgccac cttaggggtc 120
ctggctgtta cttcgtccca gggcctgact ggtagtctta gttacacaca caacacaggg 180
gagggaggaa ggagcttggg gcaaagggag ggagtccagc cctttgcctt tccttggaga 240
aggcaaggga gacaggaatg cctttggctg ggagaccctg gccagagatc agaagatcaa 300
aggatgagaa gatcaggggc gaggcaggtg gcactcactt ggaggcacca gagagaagcg 360
gcagctgctg cctcctaagg gcagggctga cccagaacgc cctcctctac ccacagcctc 420
cccagcctat ctttcctaac tttatagccc tgcttctcca ccaggagggg ctctgttggt 480
tacatgcagg tgaggagagg gatgtccact gacattcatg ctacacccat gggttctccc 540
atttaaacct cacaacatta tcttatgggg aatattagat actattttat agatgcagaa 600
actgaggcac agagaggaaa ggaactagtc caatatcaaa caactgctaa gtgttagggc 660
caagatacaa actctggcag tctgacccca gagccactga ggattacatt ataagggcag 720
gcagagaact ctattcagtc caactgcagc atgagggagt gaggctaggt atcaggaagg 780
acttcttgtt gggcaggtat tttagatcca gatcttggat ctagtctttc tatagctctg 840
atgaaccaaa tagttcggga gttagggaag agggcagatg ggtggggcgc tatccagagg 900
gaagggcata cgagagaagc ggcagaacga gagaggatca gcgcggaggg tggcgggcac 960
tggaccgcag aactggcact cgaggtccca ggggccggaa tgcgcttgga gggagagggc 1020
cgctcagcga gggcgggaca gaacctctcc cgggctggga gtgcacggcg cggtgcgccc 1080
aggtaggctt gggggaaggg tgccgagctc cggaaagttc cacaggtcct ccgcagccct 1140
ggggagcagg acccagaaac cgacgcgacg ggtggggcgc tacccgggcc ggccctaatc 1200
<210>65
<211>1200
<212>DNA
<213>智人
<400>65
tgcagcaccc ggcctccagg tggcaccaat ccgcttactt tgaggtgggc tctgacaacc 60
agctgagctg cccacagtcc ctcagactcc cgaggtcctg ggagcaggga tcaaggtggt 120
ccccaggccg taaacctgac agaggctgca ggagtgcatt tccacccagg gtgcactcag 180
cgggtgtaac tccacacccg tttctttgga gtcaaggccc ggcctctcag tgaggagact 240
gctcctggtt gcccaccgtc gggtcatccc agcctgcagt ggaaccctcc gcagcctggc 300
ctcttccagg gtagcccctc actcccctct ctcctgtcct agcagacagg ccagggaggg 360
tggacgagtt ccagctctgg ggatgtccca tcagctgtgt caccttgaac aaatcatttt 420
gcctcttggg tctcagtttc ctgcagtgtg aaacgtggtg gaggcatgag gggcaatggg 480
agccccaagg cctctttcag agacctcctc tgggtcccat gtgacctcgt ggctgtcccc 540
aaaggcaaga gggtccccag ccctgcggcc aaggccctgg gacaccctat ccaaacaaat 600
gcaggtctct gacgggctga gctttgctcg cttgggtttc tttgctttct tccttttttt 660
tttttctttc ctggatgaaa ttcctgccag ctccgaagga aggagggaag aggagcgagc 720
cgcagtgtag aaagtttcct tgactcctcc tccggctggg tctccctccc ttgccaagcc 780
cagcctgtga aactgaataa cgaagatcac tcaacaatgc ctgcccctct ctgactgcac 840
cgtcccggcg ctcccaccgc cgccgccgcc gcccaataga gcccctgggg cggtccccac 900
cgacggtgca gcccgccggg accgggagga agcagctgcg gccatcgcgc cgtgcgtccg 960
cgcccggccg ccaggtgccc cagtagcccg accgccgaga tgcccagccc gccggggctc 1020
cgggcgctat ggctttgcgc cgcgctgtgc gcttcccgga gggccggcgg cgccccccag 1080
cccggcccgg ggcccaccgc ctgcccggcc ccctgccact gccaggagga cggcatcatg 1140
ctgtctgccg actgctctga gctcgggctg tccgccgttc cgggggacct ggaccccctg 1200
<210>66
<211>1200
<212>DNA
<213>智人
<400>66
tttctcagga aaccaaccat cgggcctccc agacagtatc aaggcgctga aactcagtag 60
gtccttgagg ccagacccct caccagtcat gactgcctag ctgcctcctc actctcccta 120
attcctgttt tcccacacag ggtgacattt cttccctgct ctggaaactt ctaattttag 180
tgggctgagg agagggattt gtgactgagc gcccatctct gggctgtagc acttgaatga 240
ggccttcttc cctggcactg ctgttggtga ttggctttct gtgcagggca gggggcctag 300
atgacaaccc tgatgtttgg gtagcactgt cactgtgaga ggcatggaaa tcctccagtt 360
cttagtcttc ttggaggaag gaattcagac aagagatgcc tagcaagagg tatagggtta 420
agtaaccttt atttaaagag tcaggatctc agagagacaa gacagaacct gccactcagg 480
agatagagcc aaaagctagt gacttaggag gaattctttt ctttctcttt ttttttttat 540
ttttttgaga cagagtctcg ctctgtggcc caggctggag tgcagtggcg cgatctcggc 600
tcactgcaag ctccacctcc cgggttcacg ccattctcct gcctcagcct cccgagtagc 660
tgggactaca ggcgccagga ggaattctta tttgagcttt tagttaagga aaacagtaca 720
gcttgaaaga ggaactgctc aaaagaatga gtcagtcgct actcacgctg gggagaccct 780
cttgatgaga gttttacagg attactcacg aacggcccag gcaggggcct tactagtaag 840
cacgttttgg gaagtcctca gggcacgcag gcaccgtgac ctcacacact agtgcgctgg 900
agtgtgtcat tagcatctgg aatctctccc cagggatgtg gtttttgttt tttttttttt 960
ttttggtatt ataatgagct aaaagctatt caggggcgag ttatcagagg tgagcccgtg 1020
ctcttcagcg gagaagatcc cctacctggc cgccggccac tttctgtggg ccgtggggtc 1080
ctcaaggaga cggcccttgg gctcaggggc tgcgtttcca cacgcgcctt tcccagggct 1140
cccgcgcccg ttcctgcctg gccgccggcc gctccaacag cagcacaagg cgggactcag 1200
<210>67
<211>1200
<212>DNA
<213>智人
<400>67
tgttatatgg atgtattgca tagtggtgga gactgggctt ttagtgtagc catcacccct 60
atagtgtaca ttgtacctat taagtaattt gttgtccctc accccctccc tccctcccaa 120
agtgattaca aatattaatg atgacagtga tgacagaaat tctctccaga tgtgatctga 180
gtttggaggg caaagggatt tttgaaaatg aatcataaga gagaaatttt gcaacaaagg 240
agtgtggtac atttaaattg ctgttttttt ttttaaatac tgtgctcacg cggacctaat 300
aaactatcaa gcagacctca tggaattcca cataatgcag aagcgaggga aaaataggta 360
ttgagggaaa agcagcactg ttttcctcaa ttttaacacg tatgtgcagc ctacacttac 420
aaacttaaga cagtagcttt taacatgtga ctttgctcag ggtaacagac cattctggtt 480
atagccttac ttacagctgt ggaggctgaa tcctgatggg tctaagaagt gtcaggacaa 540
gtgttaggga tgcacctgtc tgtctgtctt aagggaatac gggtctgggc agtcttaaat 600
cggagctccc ttgaggagaa tgtcgtgcag tagccttagg aatgtgaaca ttgggagact 660
ggctgggatt ttgtaggtta tgagttgggg acacttatga tagtgaactt gagcccagga 720
gagaagccat aaaaagtgaa actgtcctgg gcacttggag gtgagtgtct ctctagtaag 780
atgcatgtga aaggctggga gctgaaagca aggagagcag aagaggctgg tgaagattct 840
aatctgcgtg tccaggggca ctcttccagg tctcaggaac gcaggtcaga atgtgcaagc 900
cagctgccgg gcacgtggct cacccctgta gtaccagcac tttgggaggc tgagagagaa 960
gatcgcttgt ggccaggagt ttgagaccag actgggcaac atagggagac cctgtctctt 1020
aaaaaaaaaa aaaaaaaagg actgagtgag ccgagcccag tcctctgatg cactgtgtca 1080
ttcatcccct ttcttaggct gtgttggttc taggctagct gctgtctttc tttggtaggc 1140
tgctaacctc tttggattgt gaatttaaaa catgttttac agtaaatttg ctgccaagac 1200
<210>68
<211>1200
<212>DNA
<213>智人
<400>68
gaactgaggg ctcctcccct ttttagacca tatagggtaa acctccccac attgccatgg 60
catttataaa ctgccatggc actggtgggt gcttccttta acatgctaat gcattataat 120
tagcgtaaaa tgagcagtga ggatgaccag aggtcgcttt ctttgccatc ttggttttgg 180
ctggcttctt cactgcatac tgttttatca gtggggtctt tgtgacctct atcttattaa 240
accagtcttg cccaatttct atctcatcct gtgaccgaga atgcggaccc tcctgggagt 300
gcagcccagc aggtctcagc ctcattttac ccagccccct gttcaagatg gagtcgctct 360
ggttccaacg tctctaacgc ggggcccctg actgctctat ttcccaaggt gtatctagca 420
tctcgcacta tacgaggcca agttaaggct tacacatttg cagaaggaaa gaggtaagga 480
agcaacctgg gaccttccac tgtctctgtt tccatctctc tctttccatc tctgttcatc 540
ccagaatctc tctgtcccta tccctaaata tcgaaaattt ctgtctctga ccatctatca 600
ttgtggctga tcatctgttt ctgaccattc cttcccgttc ctgaccccag ggagtgcagg 660
gtgtcctagc caagccggcg tccctcctag tagtaccgct gctctctaac ctcaggacgt 720
caagggccta gagcgacaga tgtttcccag cagggggttc tgaggctgtg cgcccagatc 780
gcgagagagg caagtggggt gacgaggtcg tgcactgagg gtggacgtag aggccaggag 840
tagcaggcgg ccggggaaaa gaggtggaga aaggaaaaaa gaggagaaaa gtggaggagg 900
gcgagtaggg gggtggggca gagaggggcg ggcccgagtg cgccccccgc ccccagcccc 960
gctctgccag ctccctccca gcccagccgg ctacatctgg cggctgccct cccttgtttc 1020
cgctgcatcc agacttcctc aggcggtggc tggaggctgc gcatctgggg ctttaaacat 1080
acaaagggat tgccaggacc tgcggcggcg gcggcggcgg cgggggctgg ggcgcggggg 1140
ccggaccatg agccgctgag ccgggcaaac cccaggccac cgagccagcg gaccctcgga 1200
<210>69
<211>1200
<212>DNA
<213>智人
<400>69
agctcctgct ctccgctcag tcccacagcc ttcccatgca agagttccgc agcttctcct 60
gacgactcct tcccgcaaaa tccccacccc gtccatcagc aacgctgtgg actctctgct 120
cctgcacctc ccttacctcc cttgtcacac ggagaaggaa gagccggaca ggtacccgcc 180
aggagggctg ctctgtagct gggaacctca ctgagtttgc agcaggggcc agaattgtgg 240
ggagccattc tagagaccgc attttctttt tttctttttt tttttttttt atgagatgga 300
gtcttgctct gtcacccaag ctggagtgca gtggcgcgat ctcagctcac tgcaagctcc 360
gcctcccagg ttcacgccat tctcctgcct cagcttcccg agtagctggg actacaggcg 420
cccgccacca cacccggcta atttttttgt attttgagta gagacggggt ttcaccgtgt 480
tagccaggat ggtcttgatc tcctgacctc gtgatccacc catctcggcc tcccaaagtg 540
ctggcattac aggcgtgagc cactgcgccc gaccaacccc attttcttaa tggtgccgca 600
gattgggaag tggctcccag ggcctcagcc tattggcatg caggccaggc agtgcccagc 660
tgagagtggc tcacaaggat gagtcaggag gaaatgagcg gatggcagga gaggctgcca 720
tctgtggccg cctgcatggc caggcctgtt ctcagcgctt tacagcggcc agttcagctg 780
ctctcacctc agccacctcc cgagagacac gtgggaggtg gaggctcaga gaggggaagt 840
caggactaga gcctgggcat tttgataatg acaggagtga gacgcaggtg gagagcaggc 900
caggagcctg cggcgcttct cctgtgagct gcccccagga ggcgctcgtg tgttgcccat 960
cgctcccacc ccttcttccc tccacatctc tagaaataca gacgctgcgt gcaaagcact 1020
gggtgctgat gtggcttagc atctcctgac acctgtggcc tgtcctccct ccagccgggt 1080
gacacccaga cccccagctc ctgcacaccc ctgggcaacc ctgctgtgcc cccggggtgc 1140
tgagcgtggc tttgccagtg tgtcagaggc atcaattgct aaaacaattc ggcagaaatt 1200
<210>70
<211>1200
<212>DNA
<213>智人
<400>70
tatgtcaaga atgaaagatg gctcatcatt atggaccata cagacgttaa aaggataata 60
aggaaatatg ctgaacaact ttatgccaat aatctgacat ctaataattg gatgaaatgg 120
acaaattcct taaaagaatt accaaagttt attcaatatt accttgataa cttgaatagc 180
cctctagctg atgcagaagt gaatttctca ttaaaaacct tcccacaaag aaatctcgaa 240
gcccaaatgg gttccccagc gaatactacc acaattttta gggaataagt taccccatcc 300
tactcccagg tcactgcagg cccggcttaa accgacccca aaccagacag acacagaaaa 360
cgggaggtcg gccacagagc aatctgcttc accagcaccg tccccaacct tggacaaagc 420
gttaccaagc tgagtcaggc aatacaccaa aaggataacg aatcgtgacc aagtgagttt 480
tccaaggaga gccaaacaat gtaattccct atgggctgaa ataaaaagct acaggatcat 540
ttgaatacat gcagaaaagc gttgcagaaa atttcacacc cactcataag aactcttgga 600
aaaacaggaa tagagggaac ttcctcaact tgataaaaaa caccaacaaa aaacgactcc 660
taacatcact ctgggtggtg aaagcgcact tttccctaat gtgtgggcgg caagaaggcg 720
gacccgctcg aagctccgcc cacccacgcg aggccccgcc cgcccgctcg aagccccgcc 780
cacccggcgg tcacaccgcc ttgcgcgctc ggcatgacgt cactcccacc aggcacctcg 840
ccttgtcagg agctgccagg cgccaaccgc cgacctctga ccgctacggg tcccggctcg 900
cgcaacgacc ccaaggcgca tgcccaggcg cggcgacccc attggtggcg ggcggcggga 960
gcggcgcggg cgcgtgcggg cggcggcagc ggcggtgacg gcagcctagg ccgggcgagg 1020
gccatgctga gcctcgcagc caagctggtg gccttcttct ggaggacggc ggacacccct 1080
agggaggaag ccgggcagct ggagcccgag ctcgcggaag gtggctcgcg ggaggcggct 1140
gggaggcggg tcccgggccc tcgcgtgtcg gccacgaggg agccgcgccc ataggtcttt 1200
<210>71
<211>1200
<212>DNA
<213>智人
<400>71
aggccaggct gggtgacaag ccccccgggt ggctgcacct cccactcgcc gacctgggcg 60
ctgtccttgg tgctgccggc gccatagcga gcacaagcgc cttaccttct gcccctgcgg 120
aagctgcgga cgtcccccaa acgttaaaaa cgccatatcc cactttttat acaaataact 180
accccggcct gttctctttg tccccttccc gaagccttca ggcagaccgt tccgcaaagt 240
cttttttttt gttttgtttt gtcttctaga cccagctcct cggcgctcat ctccagctgc 300
tttaagacaa ggggtggggg aaggggaggg aggcaagaaa agatgagggt gggggagggg 360
aaaagaggga atgcaagggg aaggagggag gagacgggga gaaggaaaga ttggaagaaa 420
aggatctccg aggaaggggc tgagagaagg gcagggtgaa ctggactaaa ggccagagta 480
ggaaggagaa gaggggccaa aaaagaaggg gatgaaatta agcacagaag atgggtaaag 540
aaaaaagtat cagggaaagg gcaaaataag agaaagcctt gaggataaga gggtagaagg 600
ctaaagaaca aggggaccac tgggtcgggg aagcgctgcc tgaacggcgg gacagtgaca 660
aagaaagggc gctggcgata ttcgcaccaa gggtgcgaaa cgcaatcggg aggtgagaaa 720
tggaaagaag gcgaatgccc ggctacaagt agcctgggac tgaaagggga cctgggggag 780
gggctgggcc cagggcagaa aagtccaggt tcccatgcgg cctgggccca cgtggagcgg 840
gcgctgaatc accgttcagc cgcccccctc ccctcctccc cgaccggtgc ccgcagtccc 900
cgcctcctcg gccgccgcct ccacggggcg gggccctggc ccgggaccag cgccgcggct 960
ataaatgggc tgcggcgagg ccggcagaac gctgtgacag ccacacgccc caaggcctcc 1020
aagatgagct acacgttgga ctcgctgggc aacccgtccg cctaccggcg ggtaaccgag 1080
acccgctcga gcttcagccg cgtcagcggc tccccgtcca gtggcttccg ctcgcagtcg 1140
tggtcccgcg gctcgcccag caccgtgtcc tcctcctata agcgcagcat gctcgccccg 1200
<210>72
<211>1200
<212>DNA
<213>智人
<400>72
agaatgactt ctgtttccct tcctgaaggc ttcttggtgc agtgttgagc tacaggaagg 60
cactagccac atgagcaggg cccttgctga aacccccttc ctccaggaag ccttctttga 120
ctgccatagg ctgcagaggc tcctctcccc caccttgtta tagctaacag aaccactcag 180
ttcagagctg gtggtcttct gatgatctgt cccggagatc tgttccctca gcttggccag 240
agctccaggc ttgtgagtct ggtccgcggg cattcaaagg ccctcagtgg catctgtgca 300
tcagtgagac tgcccggggt tcctgctctg aacccttgcc ctagtgcccc tagcctggct 360
gagaacggag ggtcaagtgc cggggttcta atctcaatta ctttatccaa gcatccgctc 420
gctcatttac atgtttccct gggctctcca ctctgcgcca ggcccggtac ctggagctag 480
ggaaaccgaa cattagtgct ggctcgcccg cccccgcatc cggggagctc ggcgttctcg 540
cggccctgct ccccttgttt tcaagtgcaa gttccatgtt tccgtgctgg gaataaggcc 600
agccccgggt gccaccatac tcgcctgatg tcttaccccg acccgcgccg ccgagagctt 660
gcggctacgg gaacgcggcg cgccccgggg ccacatctgg cctagcgggc gcgcgcgtgt 720
cactaagacg ctcattcacc ggcgcagctg tcaccataac aaccggagcg agggaatcct 780
ggagactgcc ggggcggggg gcgggggcgg cggtcgcagg agggacccgg cgcgggcggg 840
accgcggcgg tcgggggaca ccagctgcgt cggagcgccc agaacgcccc gcgctccgcc 900
gagccccgct ccacgcagac ccgcgggcgg gagggagcca cgcacatcgc cgccgcggcc 960
gtctccgcgg ggcggtaacc gagcctgcct cggagccgcc gaacgcccac gccagcgacc 1020
ctgactctat ggccccgggg gagcgcgccg gagccgccgc gccgcccacc cccagccgga 1080
accctagcgt cccggggagc aagcggggag ccccgggcgt ccccggcccc ggcccagggc 1140
cctgcttgtg gcccccgctc ccgccacggg gcatgggagg caggtagccc agcctgcgcc 1200
<210>73
<211>1200
<212>DNA
<213>智人
<400>73
cccggggttc ctgctctgaa cccttgccct agtgccccta gcctggctga gaacggaggg 60
tcaagtgccg gggttctaat ctcaattact ttatccaagc atccgctcgc tcatttacat 120
gtttccctgg gctctccact ctgcgccagg cccggtacct ggagctaggg aaaccgaaca 180
ttagtgctgg ctcgcccgcc cccgcatccg gggagctcgg cgttctcgcg gccctgctcc 240
ccttgttttc aagtgcaagt tccatgtttc cgtgctggga ataaggccag ccccgggtgc 300
caccatactc gcctgatgtc ttaccccgac ccgcgccgcc gagagcttgc ggctacggga 360
acgcggcgcg ccccggggcc acatctggcc tagcgggcgc gcgcgtgtca ctaagacgct 420
cattcaccgg cgcagctgtc accataacaa ccggagcgag ggaatcctgg agactgccgg 480
ggcggggggc gggggcggcg gtcgcaggag ggacccggcg cgggcgggac cgcggcggtc 540
gggggacacc agctgcgtcg gagcgcccag aacgccccgc gctccgccga gccccgctcc 600
acgcagaccc gcgggcggga gggagccacg cacatcgccg ccgcggccgt ctccgcgggg 660
cggtaaccga gcctgcctcg gagccgccga acgcccacgc cagcgaccct gactctatgg 720
ccccggggga gcgcgccgga gccgccgcgc cgcccacccc cagccggaac cctagcgtcc 780
cggggagcaa gcggggagcc ccgggcgtcc ccggccccgg cccagggccc tgcttgtggc 840
ccccgctccc gccacggggc atgggaggca ggtagcccag cctgcgccag gacacccgtg 900
gcgggcggaa cccgccaagg accgcgaagt ccagagaaag gaagctgagg agctgcccgc 960
ccgcccccgg ctgcagcccc agcagggccc tcccccggtg gcgcgcaccc gcgcgcgcac 1020
actcgcacac cgcacctcag cgcctgcccg gcctcgcccc cacccgcgag cgccgaacct 1080
cctggggccg gatgccatgg gtaacaactt ctccagtatc ccctcgctgc cccgaggaaa 1140
cccgagccgc gcgccgcggg gccaccccca gaacctcaaa ggtaggctcc ccggccgagc 1200
<210>74
<211>1200
<212>DNA
<213>智人
<400>74
tgctcccaag tgcttatgag cccatgtata tgcacatttg tgtgacatga tgcagaagaa 60
tagtgcaggt ctgtgttggg gtgtgtggtg tgtgtgtatg tgcatggtta aagggatagg 120
ttggtgtggg ggggaaaagc ctggattctg gtgctgcact gcctgggttt gcattccagc 180
cttgccacct tttaggtgag cagcctctct ttgtctcagt tttctcatct gtaagaccat 240
catcatcatc ttagagatgg tacctgttga tctgttgata atgactgtaa tactgacctc 300
atcattcagc ctgtgaggac caaaggagtt aatacttgca aagcccttgg aacagagcct 360
ggaagaagac agaaacggtg ttagcacttg gttaacagct ccatcagctt gattgtgaac 420
ctcttgaggg cagggacgat gtctgttttg cttcccaggg ggtcccctct cacctagcag 480
gacctctgca tgtagtaggt gcatgaggct agtgaatgaa tggctgtcgg cctgggcgtt 540
cagggagggc tgtgtgtgtc actacatccc tgagatgggg ctgtgtgtga tggggatgtg 600
tgtgcgtgtg cgcgcctctg ctcgctttct ggagctcgct gctatttcag gaagcctcca 660
gtctcctcct ccttatgtaa ataaacatga cagatcccat cggctgtacc agcgcgggag 720
gtggggaggc tggagtgggt gggagcgggg aggcggcggc cggaggggtg tgcgtgctgc 780
gtgcgcgtgt ggccggctgg ccgcgggcgg gcggcgtgcg cgtgtgccgg agggggcgcg 840
tgggggcgcg tgggggcgcg ggaggggcct cggccctgcc atgccggtct ccgcccgcgg 900
gggaggagac gggggaggag gaggggagca gccggccggg gcgactcggt gaccagccgg 960
ccggcccagc agaggtggct gcactgcccg tcgccggaga tggggggaca gatcacccgg 1020
agcactctcc acggtaaggc cccgcggatg cctgcgggcc cgcccacccc agcccgagac 1080
cgcctgggga ggccgggcgg aggggcgctg gggctgaggg cttggtcatg cccctacttc 1140
tcactccatg gaggggtctg gggctgtgtg ggggcacctt ttggtggtgg gcactggggt 1200
<210>75
<211>1200
<212>DNA
<213>智人
<400>75
gaccgcctcg gcctctcaaa gtgctgggat tacaggcgtg aaccaccatg cccagcctat 60
ccttttgttt tccatcctgt gttggcttgg tgggggagag gaggtgttga cacgtggagg 120
acacacatat aaggcattct tgggtgactt cgtcatcact ggaccctatc tctcaaaatt 180
ccagcgaaat ctgctcttcc ctttaaggag tgaaagaagg gtcagcattc cagaagttcc 240
tggtcatacc caggctttta atgaattgcc actggggaat cagcatcccg ttgctgtaag 300
gactataaga tggcggattg tgagagcata gggaaaggtc tcggaggtct cttgtccttg 360
ctccacgcag gtctttctgg cctgaaaatc ccgttgaaga gagcagctct tgagagtttg 420
ctccaagttc cctcggggtg atcagcacca cggacagcgg ccagggcgcc cccgaggacc 480
cgcaggcagg cagggtgcac agcggcgagc aggtgctgcg ctacgtgcgg gccagggaac 540
tcgcgcgggg aggggagagg cgccgcgggt ggcggggtct tggccggggc tgttttcgct 600
gtgagtcacc ccgtgctccc cgcgctcacg tcggtcctcg gaaagccggg gtcctccctg 660
ccttttccag caacggtggg gtggggaggc aggaagaaag cgccaaccta ggacacctgg 720
acatttgcag gaaaggaaga agcgggagac ggggacttgt ctgtgtctcc agcgcgttcc 780
tgccccccgg cccgacccgg cccatttcta tacaaggtcg gctctgcccg gtctccacct 840
cccacgtcgc aggcgcggag gggctcattc ccgggccctg atctcagagg cccggaatgt 900
ggctgataaa tcagagataa ccctgcatgg cagggcaggc ccgacactca gctccaggat 960
aaaaggccac ggtgtcccga ggagccagga ggagcacccc gcaggctgag ggcaggtggg 1020
aagcaaaccc ggacgcatcg cagcagcagc agcagcagca gaagcagcag cagcagcctc 1080
cgcagtccct ccagagacat ggatccccag acagcacctt cccgggcgct cctgctcctg 1140
ctcttcttgc atctggcttt cctgggaggt cgttcccacc cgctgggcag ccccggttca 1200
<210>76
<211>1200
<212>DNA
<213>智人
<400>76
aggaaagttc tggcatttgg cagattaagc aagtgtcttg atttgaagtc cagtttagtc 60
ccaatactcc ctcccacacc caccacatcg cacaatttgg ttttgtttat ttactccagg 120
ttaaggtaga gtctcttagc ttggtttgag tgctgtactc ttctctctgg tctgatattt 180
ggaactaaag ccaagccaga actccagggc caagggggat gttgaaaatt gtctgagtcc 240
ccagaccacc ctgccagctc atggcaaagg gagggatcag aggccacagg gaaagcactt 300
cagctgctct tcacagcatc accctctccc catttaatgg tttaggttaa caggactttt 360
tccttgaggc ttgggacacg gaagggagcc tcccctaaac caggcccttg gagagcaggc 420
cccaggggag cagtgcaact caccttcaca cccacaagac ggctcctgac ttctgctccc 480
tcctcccctc cccaaagtgg aacagagaga atatgattcc ccacgacttc cacatcacag 540
tttccaaaca atggggaaat cggaggcctc cccgtgtgca gacggtgata tttaccgcca 600
aatgcgaacc aggcagatgc cagccccagc acgcacgcag gtaacttcac cctcgcctca 660
acgacctcag aggctgcccg gcctgcccca cacgggggtg ctaagcctcc cgcccgttct 720
aagcggagac ccaacgccat ccataattaa gttcttcctg agggcgagcg gccaggtgcg 780
ccttcggcag gacagtgcta attccagccc ctttccagcg cgtctccccg cgctcgtccc 840
ccgtctggaa gcccccctcc cacgccccgc ggcccccctt cccctggccc ggggagctgc 900
tccttgtgct gccgggaagg tcaaagtccc gcgcccacca ggagagctcg gcaagtatat 960
aaggacagag gagcgcggga ccaagcggcg gcgaaggagg ggaagaagag ccgcgaccga 1020
gagaggccgc cgagcgtccc cgccctcaga gagcagcctc ccgagacagg taagggcgca 1080
gcgtggggga cccgtgctct ttccccggga tcccctgtcc ccgtcctcgc gatgcagtcg 1140
gccggctccg gctccgaagg cggacctggg cgcctctggc tctccgcggt cccgagttct 1200
<210>77
<211>1200
<212>DNA
<213>智人
<400>77
gacggagctt ggatctctct tgtggtccaa agggaaagga ttgctgaatg taaagccaat 60
gtcaccagaa aagctgaatc cacaagagag tcctggagtc caaaagagca tctcatgggg 120
aatcaggaaa gttctggcat ttggcagatt aagcaagtgt cttgatttga agtccagttt 180
agtcccaata ctccctccca cacccaccac atcgcacaat ttggttttgt ttatttactc 240
caggttaagg tagagtctct tagcttggtt tgagtgctgt actcttctct ctggtctgat 300
atttggaact aaagccaagc cagaactcca gggccaaggg ggatgttgaa aattgtctga 360
gtccccagac caccctgcca gctcatggca aagggaggga tcagaggcca cagggaaagc 420
acttcagctg ctcttcacag catcaccctc tccccattta atggtttagg ttaacaggac 480
tttttccttg aggcttggga cacggaaggg agcctcccct aaaccaggcc cttggagagc 540
aggccccagg ggagcagtgc aactcacctt cacacccaca agacggctcc tgacttctgc 600
tccctcctcc cctccccaaa gtggaacaga gagaatatga ttccccacga cttccacatc 660
acagtttcca aacaatgggg aaatcggagg cctccccgtg tgcagacggt gatatttacc 720
gccaaatgcg aaccaggcag atgccagccc cagcacgcac gcaggtaact tcaccctcgc 780
ctcaacgacc tcagaggctg cccggcctgc cccacacggg ggtgctaagc ctcccgcccg 840
ttctaagcgg agacccaacg ccatccataa ttaagttctt cctgagggcg agcggccagg 900
tgcgccttcg gcaggacagt gctaattcca gcccctttcc agcgcgtctc cccgcgctcg 960
tcccccgtct ggaagccccc ctcccacgcc ccgcggcccc ccttcccctg gcccggggag 1020
ctgctccttg tgctgccggg aaggtcaaag tcccgcgccc accaggagag ctcggcaagt 1080
atataaggac agaggagcgc gggaccaagc ggcggcgaag gaggggaaga agagccgcga 1140
ccgagagagg ccgccgagcg tccccgccct cagagagcag cctcccgaga caggtaaggg 1200
<210>78
<211>1200
<212>DNA
<213>智人
<400>78
ggattacagg catgtgccac caggcccagc taatttttgt atttttagta gagatggagt 60
ttcaccatgt tggccaggct ggtcttgaac tcctgacctc gtgatccacc ctccttggcc 120
tcccaaagtt ctgggattac aggagtgagc cactgcgccc agccacattt aaattttaga 180
gtataattat tgctgcttat aattagaagt gagaagactg ttttgaagta agggacttcc 240
ctggccaccc tcgctaaaat tgcaacctta ccctcactcc atttctcctt ctctgcttta 300
tatttctcca aagcacttat atgataataa actgtataat accgtactta ctgtgtttct 360
catgtatccc ggctacaact gtcaactgcg tgggactggt tttgtctgtt ttgttccctg 420
ctctatccct ggagcgtaaa gcagtgtctg gtatagagtg gatacttaat agatattcgt 480
tgaaccgggc cagtggcggt ggctcacgcc tgtaatccca gcactttggg aggcggaggc 540
aggcagatca cttgaggtca ggagttcgag gccagcctgg ccaacatggc gaaatcccgt 600
ctctactaaa aatacaaaaa ttagccgggt gttgtggtgc atccctgtaa tcccagctac 660
ttcggaggct gaggcaggag aatcgcttga acctgggagg cggacgttgc ggtgagccga 720
gatcgcgcca ttgtactcca gcctgggcga caaagagaga catcgactca aaaaaaaaaa 780
aattcgttga acggaatgag tgaacaaaca aatggatgga tgagtgaatg aatgaacgaa 840
ggaacaagtg accgctcgac cttctacagc gacagcggcg caggcgctcc cgcaccaaca 900
gccccccacc ccgccaccgc cagagggcgc agacaggccg ggtcccgagt gtctgtccca 960
ggcccccgcc ccacaggatc ccggcccggg agcccccgat gcagggaccc gcccgggact 1020
ctgggtcccc gcccatacct caacttcgca cgactgcgtg cctcaagccg acgcagcggc 1080
ctactctcgc actgcagacg gggaaactga ggcctgaggc ggccggggtg gggcagacct 1140
cccggcgagc ccgagccccc gcccccggct agccccgccc tggcccgtaa gaagcacccg 1200
<210>79
<211>1200
<212>DNA
<213>智人
<400>79
aataaacttc catgttgttg ttgttgtttt gaaacggagt gtcactctgt cacctgggat 60
ggagtgcagt ggcacagcct tggctcaccg caacctccgc ctcctgggtt caagtgattc 120
tcctgcctca gcctcctgag tagctgggat tacagatgca cacgaccacg cctggctaat 180
tatttgtatt ttgagtagag atggggtttc accatgttgg ccaggctggt gttgaattcc 240
tgaccttaag tgatctgcct gccttggcct ccccaagtcc tgggataaca ggcatgagcc 300
actgcaccca gccaaacttc gaggtatata attaaaagtt taataagccc tcagcctaat 360
tttaaaattc agattctttc tttctttctt tctttcgttc tttctttctt tctttctttc 420
tttctttctt tctttctttc tttctttctt tcttctttct ttttctttct ttcttgataa 480
cattattatc atagtctggt agattctgtc tttctataat aaaaatcctg tgatgttgtt 540
caaagaaact caatgggctt tctgtatgtt taccaaggaa ttaaaatctt aacaaaggtt 600
ttcaacacaa gaaatactcc cttttgtaag aattcttcat aggtttttct agcacaagtt 660
tgtttttatt gaatgatact tgatggttct gtatgttatt tcttttctac tacatataat 720
tttgattagg ggatacatta aatattttaa aactatcatt tctttttcca gaacaatcat 780
aacatgtttt gcttcttgtt gctttaaaag gaacatttta agttgctttt ttacaacaat 840
aagtgtgaaa ggaaatgcca aaatacaaac aatttcactt cttgttggaa tttgacattt 900
ccactagcta agtaatataa acatgcatca cctaaatgag cagtatttta atagcatcgt 960
tttcacattt taattgttgt cacatttctt ctttgtttag ggagacgtct ggtgaacacc 1020
cgtgggatct aaagaacaag taagatttaa agcatactgg gttgtgtgcc tggctttcac 1080
attttattta ttttattgct taatagtgtt tctttactac tgtgggttgt agcttaaaat 1140
tgttagaaat tttattatgg agtataagga ataaaagtga acgttcaaca ctttcaaatt 1200
<210>80
<211>1200
<212>DNA
<213>智人
<400>80
cctgcctttg catagaattc ctggaatgcc ttttcgtcat cttgttaaaa tcctggttaa 60
acttcaaggc ctagtttgag acactatttc catgatgtca gtcttgatcc tatcttttat 120
agcattatct ggttttcctt cctggcgcta atcacttatt aaattgtact aatcatctgg 180
tgtacctgct ttattttccc tactaatctg gaaacaaaaa taatagaacc tgactcatct 240
ttctgccttg agacaccttg tgctgtcact cttgatgcct tgcacacagt aggtgctcta 300
aaaatagttt gtggcttttt gattttacag agaagactga ggaaattaaa cccttgccca 360
ggaggcatat aaaaatcctg ttaaatgaaa gaggctcatg ctaactattg ttttgactta 420
ttgatgccaa actagacttg aacattgatg tgtcttcagg gaagaagcca aatatgctag 480
tgtaaaaaat tctaacctct gctatttacc tggagaagtt gaattagccc tgtcatttca 540
actgatgcca aaaaagcagc ttccattatt gtgtcagtaa tagactttta tcctgcatgg 600
aggaacttct cttaaatctt tctcatagca ctggtgtgct tctttgcact gatgtattta 660
cgtaatgttt cataagaagt gacagttcct tttttaggtc tttgcccaaa aggtggcata 720
agcaaagaat gaaagtcaag gtggttggct ttaggagagc ctaaaattgg gaatgcgaga 780
gctcccacgt aacacaaacc cggatagtct aagactccta cattttacaa accaagttat 840
ttccttccta atacaaacaa agtatgacag ttacaattta ttgtgtattt acaatggatt 900
gtgtctgtca tggtgattgt gatggaacca ggggggaaag agtaagaaat ctaagcactt 960
ttgtgttttc ttccttttct tttctcttcc tccccgcttt caggctctga aagtgttcca 1020
gctgaaattt cagatcggac agactcgctg cggctccgga ggcagtgatt ccaagctgct 1080
cgcgcacgct gctgccaagc tgcaggatgg tgcacgtagc caggctgctg ctgctgctcc 1140
tcactttctt cctccgcacg gatgctgaga gtaagccatt ctccccttct ctagggggct 1200
<210>81
<211>1200
<212>DNA
<213>智人
<400>81
aagcaaacct agataaatgg gacttcatcc aactaaaatg cttctgcacc gcataggaaa 60
taatcaacaa aatgaaaaaa cagcctatag attgggagaa aatatttgtg agccatatat 120
ctgataaggg gttaatatcc aaaatacatt acgttcacag aactcagcca aaataaataa 180
ataaaacacc cagttaacta acgggcaaag gatgtgaatg gacttttttt ttttttccag 240
aggaagtaca aattgccaac aggtataaga aaaggcgctc aaaatcacta atgaacaggg 300
aaaagccact aggtatctcc tcacacctgc taggatgact gttataaaaa agataagcga 360
taataagtgt cggtgatgtg cggagcaaag ggaaccttgt acactggtgg tgggaatgcg 420
gactggaaca gccattatgg aaaaccctac ggaggttcac tcaaaaagtt aaaaacagaa 480
ctaccagccc agtgttatcc gtccttcgtt aagttcaaag tcacggtgcc acttcctttc 540
ccatctaaag gggactgctc gcgacccaag ccaaggcccg caagtgtggc tctccctgcg 600
gggagagtag ggcaggaggt ggatttccag gccagaggct tccaggctgg gcccggaccc 660
cacgccgacc ccggccccgg ggggggctca gcgacctcgg cgcctcctca ggcccccagt 720
gaacctccgg ggcccataaa ggctccaggc cggctccccg gaggcccacc agcgggcgtc 780
tgggcctccc tccgcgccgc gaccgccagg aggcgccgcc cgggagagga agtccagctg 840
ggcccggccg ggcttcggag gcgccgcccg ggagaggaag tccagttggg cccggccggg 900
cttcagaggc gcagggcggg agccgcctcg cgcagggtcc tccccaagcc ggcgccaggc 960
cctgccctcg tccggccctg ccctcgtctg gccccgcccg ggccgcgagc actggcgggt 1020
tctgggtcct gtgaccggtc aggcggcgtc agcgggcgcg gcggagggct ggccggcctc 1080
gggggagttt ccgcggccgc cgggggcgcg gcggcagagc gcgaggccgg gcagggggcc 1140
agactcggag tcgaggcgcg cccgacagcc gcagcgctca tggcgggcgg aggagccggg 1200
<210>82
<211>1200
<212>DNA
<213>智人
<400>82
agcaaaccta gataaatggg acttcatcca actaaaatgc ttctgcaccg cataggaaat 60
aatcaacaaa atgaaaaaac agcctataga ttgggagaaa atatttgtga gccatatatc 120
tgataagggg ttaatatcca aaatacatta cgttcacaga actcagccaa aataaataaa 180
taaaacaccc agttaactaa cgggcaaagg atgtgaatgg actttttttt tttttccaga 240
ggaagtacaa attgccaaca ggtataagaa aaggcgctca aaatcactaa tgaacaggga 300
aaagccacta ggtatctcct cacacctgct aggatgactg ttataaaaaa gataagcgat 360
aataagtgtc ggtgatgtgc ggagcaaagg gaaccttgta cactggtggt gggaatgcgg 420
actggaacag ccattatgga aaaccctacg gaggttcact caaaaagtta aaaacagaac 480
taccagccca gtgttatccg tccttcgtta agttcaaagt cacggtgcca cttcctttcc 540
catctaaagg ggactgctcg cgacccaagc caaggcccgc aagtgtggct ctccctgcgg 600
ggagagtagg gcaggaggtg gatttccagg ccagaggctt ccaggctggg cccggacccc 660
acgccgaccc cggccccggg gggggctcag cgacctcggc gcctcctcag gcccccagtg 720
aacctccggg gcccataaag gctccaggcc ggctccccgg aggcccacca gcgggcgtct 780
gggcctccct ccgcgccgcg accgccagga ggcgccgccc gggagaggaa gtccagctgg 840
gcccggccgg gcttcggagg cgccgcccgg gagaggaagt ccagttgggc ccggccgggc 900
ttcagaggcg cagggcggga gccgcctcgc gcagggtcct ccccaagccg gcgccaggcc 960
ctgccctcgt ccggccctgc cctcgtctgg ccccgcccgg gccgcgagca ctggcgggtt 1020
ctgggtcctg tgaccggtca ggcggcgtca gcgggcgcgg cggagggctg gccggcctcg 1080
ggggagtttc cgcggccgcc gggggcgcgg cggcagagcg cgaggccggg cagggggcca 1140
gactcggagt cgaggcgcgc ccgacagccg cagcgctcat ggcgggcgga ggagccgggg 1200
<210>83
<211>1200
<212>DNA
<213>智人
<400>83
aagtgcccac ccaaatagcc tcatcattgc tgagggtctg tacatgacag tgactggggc 60
gtaggcagct gcacacacca gggctgagtc ccagcacacg tgttctacct gtgtgactcc 120
gagccttact tttctcatct gtacacagtc tctgtctcaa ggctattgga atgagtcaat 180
gatagagtgc acgtaaatca cttgcacaga gagttgttca aacaatggta gctagaactg 240
ctattgatct attgtggggt aattgtctta actgctttga aggattcagc cctatgtgtt 300
cctttgtcca gtcagatggg aaaatataaa tgagcccttc tcaatgttag gaatgacaag 360
atcaggccaa gacccctctt tctcagacta tccggaagat acacagatga cctggacagt 420
gtctgcaggc tcctgtgtat cctgaggctt cctgagggcc aagttctatg ggtgggaagg 480
cagcttgctc tctaggttgc cataactctg catctgattt gcatgtgttt gtggtgaccc 540
tgcagtttct tctggcattt ccaacttaaa atattgctgt ttccccaggc agggcagata 600
ttgatttttt tcttctctaa ccattccgat tgacccggct cccccaccca gcgaatgggg 660
gagggagggg gtgggggtga ggaagtggat gggggagaag ggaggaggga tggtgttgcc 720
cttatagcta gcacctttta ctccgtggaa cctgagtcac cggggctgat gagaatgggc 780
tctttccaga agcaagtgca tgatgaagaa agaacagagg gaatgttccc cctcgggtcc 840
atcctggtcc cttctttccc tgcatccctt atatgacctg cagttccctg agtccacttg 900
ccaccggggg cgggtggcac ccaggcggcg gggaggcggg ggaggggcgc agtgacagcc 960
gagccggctt tgaggaacct tgcagaggaa gtggcttcag aactgcttta cgcgaggggc 1020
aggaaaggcg cgggaggcgg gggaggtgcg gagatggcgc tctgcacggc ggcggaggga 1080
gggcgctggc gccggggaca cgaaaccgca gagcccggac gagtcaggga gtgaggcgcg 1140
agccgggcgc ccggggctct gcaggcgcag gcggcgcggg gacaggagca ggttaccggg 1200
<210>84
<211>1200
<212>DNA
<213>智人
<400>84
cttgaagcaa gccttcacgg gggaaagtgc cgggagaaag gagatctctc tttgggtccc 60
atgagtgaac catccatacc aggttccact tagggcattt aggggaactg gtatctccac 120
agtaattact agagcagctc tggggaacgg agggttggct aaggaagaaa agctccccca 180
acccttgggg cgagggagcg ttctctcaat ggagcccccc caactcccct ccacccccca 240
ccagtcttcc aggaaagagg aataccctac ccggcagggc tgcgaaggaa ggggaaatcc 300
aaccagagcg aaagtcgcac gcggacagct ctgccagccc ttggaggcat ccggcggtca 360
cccacgggac aaagcgcggc tgcgggagcg cgcgcggggc attccggacc cgcgtcgagc 420
tccgctctag agggggcggc gggcggcgac aagccggaga gaggaagggc caaggagcac 480
ggccctcctg tcggcaccat cagcgggaga gtggcgagcg gacgcctaga cggaggggcc 540
ctactcagac cccatcgagc cagttcccaa gcttttccct ccgacctgct ccctcccggg 600
gcgcgtgagg gtgcgggtcg ggggtgaacc tggtgttggg gaaagtgatt ggcaagggaa 660
agaggcaggg ctgaaggcct agggcccccc gcagaaatgc gccctctgag ctgtactgta 720
cagaggcgct cctctgcgga atcctgcagc tgctccaggt gaagacgccc ccaaatccac 780
actcgcgcag acgtcgcctg gcacggaccc tacccccttc ggtccgtcgg cggttctctt 840
gggtcgtcct tcctgccact ccgactctcc ccgcccccgc cccgcccagc aggctgcggt 900
tcctttaaag gcgcgctggt gtggggcggc cccttctctc ggggctggct cgggagtagc 960
gcagtcgcca aagccgccgc tgccaaagct gccgccacta gccgggcatg gccatggcgt 1020
ccccggccat cgggcagcgc ccgtacccgc tactattgga ccccgagccg ccgcgctatc 1080
tacagagcct gagcggcccc gagctaccgc cgccgccccc cgaccggtcc tcgcgcctct 1140
gtgtcccggc gcccctctcc actgcgcccg gggcgcgcga ggggcgcagc gcccggaggg 1200
<210>85
<211>1200
<212>DNA
<213>智人
<400>85
ttcaagatgg tgaccgcaga gcgttaaacc agacaagggt ccatgaaggc ttgaagcaag 60
ccttcacggg ggaaagtgcc gggagaaagg agatctctct ttgggtccca tgagtgaacc 120
atccatacca ggttccactt agggcattta ggggaactgg tatctccaca gtaattacta 180
gagcagctct ggggaacgga gggttggcta aggaagaaaa gctcccccaa cccttggggc 240
gagggagcgt tctctcaatg gagccccccc aactcccctc caccccccac cagtcttcca 300
ggaaagagga ataccctacc cggcagggct gcgaaggaag gggaaatcca accagagcga 360
aagtcgcacg cggacagctc tgccagccct tggaggcatc cggcggtcac ccacgggaca 420
aagcgcggct gcgggagcgc gcgcggggca ttccggaccc gcgtcgagct ccgctctaga 480
gggggcggcg ggcggcgaca agccggagag aggaagggcc aaggagcacg gccctcctgt 540
cggcaccatc agcgggagag tggcgagcgg acgcctagac ggaggggccc tactcagacc 600
ccatcgagcc agttcccaag cttttccctc cgacctgctc cctcccgggg cgcgtgaggg 660
tgcgggtcgg gggtgaacct ggtgttgggg aaagtgattg gcaagggaaa gaggcagggc 720
tgaaggccta gggccccccg cagaaatgcg ccctctgagc tgtactgtac agaggcgctc 780
ctctgcggaa tcctgcagct gctccaggtg aagacgcccc caaatccaca ctcgcgcaga 840
cgtcgcctgg cacggaccct acccccttcg gtccgtcggc ggttctcttg ggtcgtcctt 900
cctgccactc cgactctccc cgcccccgcc ccgcccagca ggctgcggtt cctttaaagg 960
cgcgctggtg tggggcggcc ccttctctcg gggctggctc gggagtagcg cagtcgccaa 1020
agccgccgct gccaaagctg ccgccactag ccgggcatgg ccatggcgtc cccggccatc 1080
gggcagcgcc cgtacccgct actattggac cccgagccgc cgcgctatct acagagcctg 1140
agcggccccg agctaccgcc gccgcccccc gaccggtcct cgcgcctctg tgtcccggcg 1200
<210>86
<211>1200
<212>DNA
<213>智人
<400>86
tactcaggag gccaagacac gagaatcgct tgaacctgag gggatggggg gcagaggatg 60
cagtgagccg agattgccga gatagcgcca ctgcattcca gcctgggcaa cagtgagagc 120
ctccatctca aaaaaaaaaa aaaaaaatgg acttcttcct cattgacctg tggtggctcc 180
aaggccatca aaaaaaaaaa aaatggactt cttcctcatt gacctgtggt ggctccaagg 240
ccatcatctc acagcctttt tttttttttt tttttttgag acggagtctt gctcccttgc 300
ccaggttgga gtggagctgc atgatctcgg ctcactgcaa cctccgcctc ccaggttcaa 360
gcattctcct gcctcagcct cctgagtagc tgggattaca ggcgcgtgcc accacgccca 420
gctaactttt gcatttttaa tagagacggg gtttcaccat attggtcagg ctggactcga 480
actcctaacc tcatgatccg cccgcctcgg cctcccaaag tgctaggatt acaggcgtga 540
gccactgcgc ccggcctcat ctcacatctt tcttcctctg cagcacacga cacgccctag 600
ttggaaacaa agtcggagtt tgtggattgg gggaagggcg gggtctaacc tcaggtcagg 660
cgccgtgcaa ggtacatctt ggcacccgga agaggcccag tacagttgcc cccgaggtga 720
cccgacctcc cctaccaatt gaggcgccct tgttgccagg cttgcggcgg gggagcggcg 780
ggggagcgac ggggatgcgc tcattggtca aggaaggggc gcctgttact agaggcgaga 840
accggagccc attggtcgga acacctcaca atggacccca gcggcgcgca aaatccttat 900
gattggtttg ctggctgcct cgggagaccc tgttgccagg atacttggcg ttcccgaccc 960
gacccccgtt ccccattggc tgtcagggca aaagccgcca tctaatgagg agcgaggtgc 1020
ggtgccccga agcgctcgct tcccgcggtg cgatctagtc ctgcagtagg cggcccgggg 1080
ccacaccgcg gccgcccaag ccagtgcaag gcccaggggc ctgacatcgc tcccagcgct 1140
cgaggaccga ggcctgctgt ggaggacacc gtgctccctc gggacctgct ctggattccg 1200
<210>87
<211>1200
<212>DNA
<213>智人
<400>87
caaaaagcag ccggggatgg ggcgagaaca gaggacttcc ccactgagcc cacatccaac 60
ctcacccaga accccttctc aggtccagtt gctgctccct attaggggta aatgtgttta 120
tgcgcatcat ttccatcatt tctttggggg aaaattggat tctttcctcc tcctcgctac 180
tcgctctccg actctgccag cccatctcct gagagttctc ctgtgtaagg gatgcaaggg 240
ccaccagcac caggtctctg aaaggacgcc ggagccagtt tccggtttcc aagggttgga 300
ccagtgctgg aggggggaat cacaaactgc ccttccagga ccctaccctc tctactaccc 360
caggatgctg aaaaaggcta ttctgcctct cttcccctgc tcagctcttc cccgcctcct 420
gcctccggcc ccagcagagg ccgcgctccc actgcgcctc tcgcctctga gaaatggcgc 480
agcaagcgct ccgcggagag cctggaggcg gggcgccctt ctctgagtcc gcggggtcgc 540
accccgagcc agtcggccag acctgcatcc cgcgtagcat ccctgccctc tctgtgcagc 600
ggaaagggca aaaggcaggg actgcaagcg ggcgcgcacc gggtaggaag agcggctctg 660
cgtaggtgcg cggacccggg ctcctgggtt ccatccccgc cgcgcacctc ggggtccgca 720
cccggctcct gccgggccct tttcggccgc accccgctcc cgcaccccgc tcctccccaa 780
gccccacccg gcccaagccg cgcgtcccgc actgagctcc tacacgcgcc gcgccccggc 840
cgcaccccgc gcagccagag caagcactgg agccccgccc cttcccgcac cccacccgcc 900
tccggccccg cctggcccac ccctggaccg cccccgcccc gccccgcccc tacccgctcc 960
tccggcgcag ccggcgctta cctcgcttca gtcccgcgac cgaagcaggg cgcgcagcag 1020
cgctgagtgc cccggaacgt gcgtcgcgcc cccagtgtcc gtcgcgtccg ccgcgccccg 1080
ggcggggatg gggcggccag actgagcgcc gcacccgcca tccagacccg ccggccctag 1140
ccgcagtccc tccagccgtg gccccagcgc gcacgggcga tggcgaaggc gacgtccggt 1200
<210>88
<211>1200
<212>DNA
<213>智人
<400>88
gacctcaaaa agcagccggg gatggggcga gaacagagga cttccccact gagcccacat 60
ccaacctcac ccagaacccc ttctcaggtc cagttgctgc tccctattag gggtaaatgt 120
gtttatgcgc atcatttcca tcatttcttt gggggaaaat tggattcttt cctcctcctc 180
gctactcgct ctccgactct gccagcccat ctcctgagag ttctcctgtg taagggatgc 240
aagggccacc agcaccaggt ctctgaaagg acgccggagc cagtttccgg tttccaaggg 300
ttggaccagt gctggagggg ggaatcacaa actgcccttc caggacccta ccctctctac 360
taccccagga tgctgaaaaa ggctattctg cctctcttcc cctgctcagc tcttccccgc 420
ctcctgcctc cggccccagc agaggccgcg ctcccactgc gcctctcgcc tctgagaaat 480
ggcgcagcaa gcgctccgcg gagagcctgg aggcggggcg cccttctctg agtccgcggg 540
gtcgcacccc gagccagtcg gccagacctg catcccgcgt agcatccctg ccctctctgt 600
gcagcggaaa gggcaaaagg cagggactgc aagcgggcgc gcaccgggta ggaagagcgg 660
ctctgcgtag gtgcgcggac ccgggctcct gggttccatc cccgccgcgc acctcggggt 720
ccgcacccgg ctcctgccgg gcccttttcg gccgcacccc gctcccgcac cccgctcctc 780
cccaagcccc acccggccca agccgcgcgt cccgcactga gctcctacac gcgccgcgcc 840
ccggccgcac cccgcgcagc cagagcaagc actggagccc cgccccttcc cgcaccccac 900
ccgcctccgg ccccgcctgg cccacccctg gaccgccccc gccccgcccc gcccctaccc 960
gctcctccgg cgcagccggc gcttacctcg cttcagtccc gcgaccgaag cagggcgcgc 1020
agcagcgctg agtgccccgg aacgtgcgtc gcgcccccag tgtccgtcgc gtccgccgcg 1080
ccccgggcgg ggatggggcg gccagactga gcgccgcacc cgccatccag acccgccggc 1140
cctagccgca gtccctccag ccgtggcccc agcgcgcacg ggcgatggcg aaggcgacgt 1200
<210>89
<211>1200
<212>DNA
<213>智人
<400>89
tccccccatg gaggctgccc tctagttcgt cctttagagg aagcatgacc aagggtctgc 60
tggtactttt ctctccctct ctaagaattt cctcaggaga ggaaaaagtt agctttcttt 120
tctctgctcc tgagtgccat ggcctgcagt acgtgaccag tccttggcac agagtcactc 180
agggctcatg gtagatgctt agcggtcaca gccagtagct gcgcagtgtg gcagcagctg 240
agatccatac tgcagcctga aagttgtgtt tcagcttctg aggttacaag tgtatccagt 300
gtttacatca gagataaagc cccctttccc ctctctccta cgggagccct caacaagaca 360
gatacacggg ttgggtggag tgagaccaca tccagcagag gcaaagcttg ctaaaagaga 420
gaggaggagg agggggagag ggaggaggcg gcacggcgtc ccttggcagc tccgtgcatg 480
ctgcggcagt tgcaacagga gaaccgagta ccagttgctc aacactttat cactttgcat 540
tgctctttct cctcccttaa gtgaatttcc attttgaggg tacagctcca caggagaaag 600
gtgtggtggt ggtagtggtg gagggtgtct gtggggggga tggtggtgcg acgggagttg 660
gaatgtccag tgtggggaag caaaggagtg cctactagga tgcgaatacc acttggccct 720
gggctcgctc cgctttagcc ttcccctctc gctggggaga aacaggcggt ttgtgaggga 780
gactgagaga ggggcgtgtt tgtggtggtg gcggcccatc gggggtcctt gtcctctccg 840
aatacccgga ctgctgaggg gaagggccgg gggggccccg gcggttgcca tggtgacgca 900
gggtcggcgg ctcagcgccg tagagacaaa gccgcccgcc cgccagcccg ctagctcctc 960
gcgcgagctc ctcctccacg ggaacctccc tcccctccca ggcgccgccg cagccggagc 1020
ggctcccggg ccctgggccg ccgccggcca ggtaaggcga tcgcgcccgc ggccggggag 1080
gggtcggcgg gacgccgggc ctccccaacg ctggggcagc agccagcccc gcagtcctgg 1140
acggcgccgg gccgcccaag cgcgccgagg agagggggcg gcaaacttcg ggccgagcgg 1200
<210>90
<211>1200
<212>DNA
<213>智人
<400>90
gagggagaga tgcagggagc tggattttag ctcctaaggt agaaaatttc caaaaggctg 60
atcaaagatt aaatggctgc cttaaaaggt aatgagttcc ttgttagtgg aggtgttcaa 120
ccactgcttg gtgggaagac actgtaagga ggattcaggc aagtgggaag ggggcttttt 180
ccagtccctg aaatcaatga ttctaacagg aaaagatgct ccggggtgcg gtgagcgctt 240
acctctgctc ttgcagagac actgacagac gttcattcaa catctgttcc tgccaggcac 300
tgtgcgcgct gaacacagaa gtacagcctc tatgaagcag ccgctgtagg cctcagagac 360
agctgataga tgtaacactg ttgtctccat gtttcaaact tcggtcatgg tcttactagg 420
tctcctcatt aaggggactc actatgtgtc cagtaacgct ttcttgttac cagatgacag 480
agagtcaggc tgtcagagtt cacgacttta ggtgcacagt ttcaccctgt ctggtccttg 540
ggagacggag aaggggtcag gagaaaacgt gggtgaagag gcagcaaagc cgcaggagat 600
atgaactaat tgctcaacgt gggtgtagca cggattaggc cttttacagc aagcgctgcc 660
agcagggaac tggtggatgt actcttgacc acgctcggct ggactctggg gagcccaaga 720
cgggtaagac taggtccccg gccccagcag ctggtggggg cgccgcaggt tagagacgtg 780
aggccgcgag gctgagggct gtgaaggcgg tgggcacgca cggcgtgccg gggccgcctg 840
gcttcgcggc gggggaggta acactgcgac accccgcaga cgctgtcagc cggggtcgcg 900
gccccgcgtg cgcccgatca tctgactgct ggggagtgcg ggggcgcggg agccaggcga 960
gccagcgcag gcgcgcgctg cctcctccgt ccccaccgag tccccagcgc gtgcgcgggg 1020
ccgtggccga ggcctgcgcg ccgcccggcc gcctgcactg cgcgcgcgcc caccccgcgt 1080
gggaggcagc gggaggggcc cggagaggtg tggagcggcg cggcgggagg ctccgtgggc 1140
ggccacggga gacagcgccg gcgggagcgc gcctctcggc ctttcctccg cgcccccgcg 1200
<210>91
<211>1200
<212>DNA
<213>智人
<400>91
ttagctccta aggtagaaaa tttccaaaag gctgatcaaa gattaaatgg ctgccttaaa 60
aggtaatgag ttccttgtta gtggaggtgt tcaaccactg cttggtggga agacactgta 120
aggaggattc aggcaagtgg gaagggggct ttttccagtc cctgaaatca atgattctaa 180
caggaaaaga tgctccgggg tgcggtgagc gcttacctct gctcttgcag agacactgac 240
agacgttcat tcaacatctg ttcctgccag gcactgtgcg cgctgaacac agaagtacag 300
cctctatgaa gcagccgctg taggcctcag agacagctga tagatgtaac actgttgtct 360
ccatgtttca aacttcggtc atggtcttac taggtctcct cattaagggg actcactatg 420
tgtccagtaa cgctttcttg ttaccagatg acagagagtc aggctgtcag agttcacgac 480
tttaggtgca cagtttcacc ctgtctggtc cttgggagac ggagaagggg tcaggagaaa 540
acgtgggtga agaggcagca aagccgcagg agatatgaac taattgctca acgtgggtgt 600
agcacggatt aggcctttta cagcaagcgc tgccagcagg gaactggtgg atgtactctt 660
gaccacgctc ggctggactc tggggagccc aagacgggta agactaggtc cccggcccca 720
gcagctggtg ggggcgccgc aggttagaga cgtgaggccg cgaggctgag ggctgtgaag 780
gcggtgggca cgcacggcgt gccggggccg cctggcttcg cggcggggga ggtaacactg 840
cgacaccccg cagacgctgt cagccggggt cgcggccccg cgtgcgcccg atcatctgac 900
tgctggggag tgcgggggcg cgggagccag gcgagccagc gcaggcgcgc gctgcctcct 960
ccgtccccac cgagtcccca gcgcgtgcgc ggggccgtgg ccgaggcctg cgcgccgccc 1020
ggccgcctgc actgcgcgcg cgcccacccc gcgtgggagg cagcgggagg ggcccggaga 1080
ggtgtggagc ggcgcggcgg gaggctccgt gggcggccac gggagacagc gccggcggga 1140
gcgcgcctct cggcctttcc tccgcgcccc cgcgtcccca gccggccgct ccgagaggac 1200
<210>92
<211>1200
<212>DNA
<213>智人
<400>92
acaaaaaaat tccaatagtg attagtaaca accagatact gtgacagtgc cccattgcca 60
ttccatggga gatgcaagag cattgtctca gtaataaaat atgatgttat caggcattta 120
tggctcctgg ggaaaaaaat gcaattgctt gctgttttga tattatctct gactatgctt 180
gcttatcatt tgccatttct atatttagta gccagtcatt ttgaagttaa aaaaaaatca 240
aggtttgcat tgtaaccaca aaccagtctt tgtgaacagg aatcctggag gctattaatc 300
agcttttaaa ggaggtaagt catggtggtg gtggggtatc tgaaattttg gaagttccga 360
gctcacttta agagttgaga tgggtgggag ggctgaaaac accaccattc atcattcttc 420
agttatctcg agactcaact taaacatttt taatcaaaaa gatgggaggg gacacgggtc 480
acatctcagg tttgggggaa tgtgtgtgcg tgtagatgtg aaaactgagc caaaatattc 540
cactgtgaag agatctccct tctcggctgg tggacatcaa ccttaccaag taatctttgg 600
agcaagtaac taccaaataa agccgttcca aaacttctac gtaagctcct actttttaat 660
gagtacgcat ttctccccat tttcttttcc tctccaagga ctgagatagc tggagcaagg 720
atgggtcccc ctctgatttc gtccccgccc cagccaatct gagcccggat gctaattagc 780
tgcgctcccc tgatgaacac gcctttgtca caagtaggcc cggactacaa agcccagaat 840
gcctcacccc tccctgatca atgagggctt atttaaatga tctctgaggt cttggaccca 900
ggccaatcag ctgtcagggc tcatgataaa tcgcaatgca ttattgataa taataattac 960
tgggacatgc gcgttccggc cgaagggggg taaatttccc aactccagga atttgtggcg 1020
gagagggcaa ataactgcgg ctctcccggc gccccgatgc tcgcaccatg tcgaggcgca 1080
agcaggcgaa accccagcac atcaactcgg aggaggacca gggcgagcag cagccgcagc 1140
agcagacccc ggagtttgca gatgcggccc cagcggcgcc cgcggcgggg gagctgggtg 1200
<210>93
<211>1200
<212>DNA
<213>智人
<400>93
tgtaacatgg acctctctgt gacgcgcaag tattatctgg cagttacatg gtgccgcctg 60
tgcagctggg cgccaccacc agcttcctgc cctgtgcgat taaaaggcca gcttcgggga 120
cagcagcctc ctcaacgcaa agcgaccagc cctgccaggc gtcggctgca gctggtccaa 180
ggttgacggt cccagggccg cattctcctt ccggtcacct cagactctgg aaagagagcc 240
atggagggcc tcagagcgcc cctctgcagt tccttgagga aaacaagggc ctccccctct 300
tggctggagc agccaagtgc ccacggggaa aatggtcccg tccaccattt caggcaaacg 360
cccccatagc tgtaataaac atgtgatggg tttcctgcac caagaaagga aaattttcct 420
taaaaataac aaaaagaggt ggggagggga ctctaagttc catttaagat tttccaaact 480
cgttgtgtct catgcatacg ctgaggctta acatgaaaat ttggagcgaa agtccccacg 540
gttcaccaca gggaatgaag taaagtatct cgccggtagc tctaggtctc gtaaaccgtg 600
gagctccttt agtataaggc cctattatgt gccacattag atgagaagaa aataagagga 660
aggatacggt agagccttta gaatggggtt cagtcttagg actcgtagga taaaggaagg 720
tcgtttccct ccgtttgagg cagggaatca aacaaaacac cggcaccgca ggcaccgcag 780
tcgcactcct ggggcctcgt ggctttcccg cgcgcccgcc ttgggggcgg ggaagaaccc 840
ggatggaacc acccttgcag cccggacccc ccgccgtctt tgaatggcag cggggcggag 900
ttgccctccc ttctgtgctc tgactggttt ggctccgcac tctcctcttc gtgattgggc 960
tttcctagtg ccagtcacag agcgacgctg gtctcccaga ttgttgcaga aggagacggc 1020
gtcgacgtct gactggactc gcggcgactt acctttcagt cgtgcgctcc tgatccggcg 1080
ctcggaattt gtccccggct tcagggctgc ggggcctgga aggaggcgta tcgaggcggc 1140
tcgaaaacga tccaggggag ccgaggcgct cctcttgtca tcccactcag cgccatgtcc 1200
<210>94
<211>1200
<212>DNA
<213>智人
<400>94
tttaaaagtc ccactgaaaa cttttttttt ttccagatcg aaacacaagt ttaatagtca 60
ttcagatttc attccagtct aaagaaactt atagaaatct aattatctgc cagaataacc 120
gctttaaact gactgtaaga accacagtta ctttgcagct aaaacagatt gttctcttcc 180
cccaaacaaa ctcggacatt tagacaaata ttgctgctgt ctttacattt tagaaatcag 240
tattaaggct cacctgttac tgaacacata cgagaaacag ttttgttatg cgtatcttat 300
atacatcatg tatacatttt cgtactttca catgatgtgt ataataagat acacataaaa 360
actggttggc ttgtcatgag taaatgcttt attctttaga gtgaaggaat attggataca 420
gaacgtcgtt ccatatttaa tcttgcttta gaaaattagg atttatcttg gacacagcat 480
tttgaatata acacaggcaa gttgagtcct gggggaaaaa ttgtattttt aaatttatta 540
tcaacggtgt ctttcgcatt tgagaaaaca catttgaaga tgcccatgca gttccttgga 600
agtaaactag gtcacccacc actgaaacac cctcggcttc tgcaaaaaga tgtgctttaa 660
agagaataga atggacgctc ggtatgttca tctaaacgac cttgggcaag tacgtcgatt 720
ccaaggtaca atcagccctc ccagacggct tttcgagtct ccctaacccc ggtgggagag 780
gacgcggcgc cagagcccag ctccggctag ttttcccggg ggcaggtgta gccttgggcg 840
cggggccggg ggaggggcaa ggggcgggcg tggggttgga ctgggacgtg ggactcggac 900
cacggcctgg gcgtgggcct aacgacgcgg gaccggcccg ccctcgccgc tccattggcc 960
acatctgtgc agaaaaggcc ccgcggccca ggggcgcccg cagtgtcact aggccggctg 1020
ggggccctgg gtacgctgta gaccagaccg cgacaggcca gaacacgggc ggcggcttcg 1080
ggccgggaga cccgcgcagc cctcggggca tctcagtgcc tcactcccca ccccctcccc 1140
cgggtcgggg gaggcggcgc gtccggcgga gggttgaggg gagcggggca ggcctggagc 1200
<210>95
<211>1200
<212>DNA
<213>智人
<400>95
tgttctccag agcaggaaac aagcttggag agtgcgataa ctagcccaag cttcacaatg 60
ggtgagtggc aggactgagg tttgattcgg gtctcttccc agagagacac tgggagagat 120
tcttgcccca ggtcttttcc cttcaggccc tcaggctcag cacctctctg aacatctgtc 180
cctggggagt gagaatctga actaaaatgt aagccaagaa aacacaggct cttcattgaa 240
tctttggaaa ctcctttcct gggctgtagg aggaccttcc tgagccttag gcacttttgc 300
ctttgctggc tctttcctcc aagtcaagca tattttatga ctgtggaggt ataaatacaa 360
atatattaac attatatagt aaaacatttt gtttgacata aattttttct tctgattttt 420
acagaaaaca ttttcataga tctccaaaag tatcgtgggc cctaagcgct gtagctaagt 480
cgtttctcct ttctcagcct ccagtctgac atgttccact atggccttgg gaagagcaat 540
gggcccggag tcgccgcatc taaccctgct gtaactggtc gcaagtcaca gtttgctcat 600
ctataaagtg agcgaaagta atgtaatctt tattgggagt agggaacatg aaggcgagtc 660
gatacagtaa gtaagccgcc aagcatattg ctaggcacag agcaggtgtg caacaaaagt 720
tatttctcag gctttccctc ctctgagcgc cgtcctccag agggtccgga gtgtagctgg 780
gggttggagc agcagcctcc taggcgatgg gacagagccc acagggtccg gtatgccacg 840
gtttcttcgt cagaccctgg gaatccaacg tcgcaaaata aacacggccg cgccgctaat 900
cgccagttcg gaggaaacaa aacagcgctg cgctggggga tctgggcaaa atcagccctc 960
cctcctcccg ctccttcgcc gcggccctcc cctcctcgcg ctgctctcgt tcgcttggct 1020
cagctcagct cagctcagcg cagctccgcg gccgccaagc cgaggcgggc acggtctccg 1080
agtcgcggac gccagctccg agctccctct ctccgccgcg cctccgccag gtcgcgcctt 1140
cgtcgggacc acttcgggca ggagtcgcgt ggcgaaggcc tgcggccgcg gcacaaagtt 1200
<210>96
<211>1200
<212>DNA
<213>智人
<400>96
agagggttca agtttagatt tcaggctaaa cttctgggct tagagggtcc tgagcatggg 60
actggataaa ggagggaagc catcatctct tcagaagatg ttcagaaaag ggcatacacc 120
cagtctatct gagctgggag agagctgctg ttatgccctg gggcaggggg atggatgaaa 180
tggcatttga gggctcagat tctctttggg gcaagacctg acttcctatg gactcccagg 240
agcagcaggg gagttctgag aggaactgtg attgtccaga gtggagtttc tttgagactt 300
gccctgtacc taaccccaaa cagatttgat acttagagac ctctaacccg gcatctcatt 360
gtacagctgg gaaaactgag acccaggagg aaggggcctc tccgagatgc cacagtgagt 420
caagagtcct cacttcagag ggctggagaa taatctactg aggcagggcc agggcacctg 480
tctgagaggg gcttctaagg ctgcaagctt ttccccttcc gtggactgca ttcacacctt 540
gttcggtcct gctggggccg gggctctcct tccttgcccc ttttccttgg cactctttcc 600
acaggccctg tgtggtctgg gctctaccga gaggtcccca aggagagctg gcgtgtcagt 660
cagccaagaa gcaagcaggc aggcaatgcc agcatgcagg tggcggggct ggcaggggag 720
ccggcaggag ggccggacac ccggagccgg ggaactgtaa tgttcaggga atttcaattg 780
gcattgctgt cccgttccag ccaactggct aacggtgccg agtttgaatc agtgacccgc 840
ctcctggtcc ctcctcctta gccggcctct ctccctccct ccttttttcc ctccctcggt 900
ggccttccag gaggcgggag gcgcccgctg tcgaggcagc tgagccccgg caaccgctgc 960
tctccgcctc tcccctcgcg gggccggctc atggagcgca gggaccgggc tggctctcgc 1020
cgagccccgg gcctctttta gcctcgtccc cagagaggga ggagccggtg cccggcacag 1080
ccccgccggc cctagaagct ccccacgcgc caccatgcct ctgctggacg ttttctggtc 1140
ttgcttcagg aaggtgaagg taagtgactg gccagcccca gcccatcccg ctgctcaggg 1200
<210>97
<211>1200
<212>DNA
<213>智人
<400>97
agtgtgagac cagcctgggc aacatagcaa gacttcagct ctacaaaaaa tgtaaaaatt 60
agctgagcat ggtggcacac acctgttatc ctagctactc aggaagttga ggcaggagat 120
tttcttgacc acaggagttc caggctgggt agctttaagt gagtcatgct taaagtctgc 180
tcagtttctg tctttgtaaa tgtgagggat agcagttgaa ctgcatgagg tcctggatac 240
tctcagacct gactaatagg agtcctcaat tcaacaatga aatcaaggtt gtgaacttgt 300
gttggaccct tgtgatgaaa ggccagagag aaatcaaagc cgaaggctct tgtttcttac 360
tgaatttgaa tggactttct ggtggtgctt actatcagaa ctcctggaag ccctcccctg 420
ccacgattaa tgttcgtgcc ccaaattttc catgcatttc tctgcggagg tagagttcag 480
acttggggta ggggacagaa gcctggggta ttggggaagt tgcagagcca ctggggcctg 540
agcaacgtag ggatggcagc ttcctgctca aattcctaat tatctggttt tcccctacca 600
attggagatt tcactgaagt tgtgtcttct ggacatccca taaattatcc gagcaagtca 660
ctgaaccctc ccgggcacat agcatatgtg tttaaatccc ccaaacagtg ccggactcat 720
tcagaactca ataaatatta gcctgtgtgc ctggccaagt cactgcttga gcctcagtct 780
ttgggcttgc acctcctccc tggcagcggt gtgaccggag ggaaaggcag cggcgagggc 840
cttggaggac ctgcaggcag tgccccgccc acccagattt gggtgacttt ctggcgagtc 900
cggtgggcca gactgcgccc ccattggccg aggggaggtg ggcggggcgt ccctacagcc 960
ctactcgccg acgctccctc cccacttgag ctgagtggac tcgggttgac aacggctaag 1020
cagccgcggc agctgctctt ctggctggca ccgtcacccc tgcccgaccc caggccccgc 1080
gtgtgtcccg gacggagcag tccctcctgg gctcgcctcc tgcccgctcg ctctgtgtca 1140
gcgcccgaac ccaaaggggt ggacgcggcc tccaggtagg agtctgggcg acggcagggg 1200
<210>98
<211>1200
<212>DNA
<213>智人
<400>98
gggctgagag agggggaggg tcactgcttc ttaatggctt tctgcccaga aagcctctag 60
aactgcctgc tgctgacttt ctttcctttc agggcatcca gagggttcaa gtttagattt 120
caggctaaac ttctgggctt agagggtcct gagcatggga ctggataaag gagggaagcc 180
atcatctctt cagaagatgt tcagaaaagg gcatacaccc agtctatctg agctgggaga 240
gagctgctgt tatgccctgg ggcaggggga tggatgaaat ggcatttgag ggctcagatt 300
ctctttgggg caagacctga cttcctatgg actcccagga gcagcagggg agttctgaga 360
ggaactgtga ttgtccagag tggagtttct ttgagacttg ccctgtacct aaccccaaac 420
agatttgata cttagagacc tctaacccgg catctcattg tacagctggg aaaactgaga 480
cccaggagga aggggcctct ccgagatgcc acagtgagtc aagagtcctc acttcagagg 540
gctggagaat aatctactga ggcagggcca gggcacctgt ctgagagggg cttctaaggc 600
tgcaagcttt tccccttccg tggactgcat tcacaccttg ttcggtcctg ctggggccgg 660
ggctctcctt ccttgcccct tttccttggc actctttcca caggccctgt gtggtctggg 720
ctctaccgag aggtccccaa ggagagctgg cgtgtcagtc agccaagaag caagcaggca 780
ggcaatgcca gcatgcaggt ggcggggctg gcaggggagc cggcaggagg gccggacacc 840
cggagccggg gaactgtaat gttcagggaa tttcaattgg cattgctgtc ccgttccagc 900
caactggcta acggtgccga gtttgaatca gtgacccgcc tcctggtccc tcctccttag 960
ccggcctctc tccctccctc cttttttccc tccctcggtg gccttccagg aggcgggagg 1020
cgcccgctgt cgaggcagct gagccccggc aaccgctgct ctccgcctct cccctcgcgg 1080
ggccggctca tggagcgcag ggaccgggct ggctctcgcc gagccccggg cctcttttag 1140
cctcgtcccc agagagggag gagccggtgc ccggcacagc cccgccggcc ctagaagctc 1200
<210>99
<211>1200
<212>DNA
<213>智人
<400>99
tggggagggg ctgagagagg gggagggtca ctgcttctta atggctttct gcccagaaag 60
cctctagaac tgcctgctgc tgactttctt tcctttcagg gcatccagag ggttcaagtt 120
tagatttcag gctaaacttc tgggcttaga gggtcctgag catgggactg gataaaggag 180
ggaagccatc atctcttcag aagatgttca gaaaagggca tacacccagt ctatctgagc 240
tgggagagag ctgctgttat gccctggggc agggggatgg atgaaatggc atttgagggc 300
tcagattctc tttggggcaa gacctgactt cctatggact cccaggagca gcaggggagt 360
tctgagagga actgtgattg tccagagtgg agtttctttg agacttgccc tgtacctaac 420
cccaaacaga tttgatactt agagacctct aacccggcat ctcattgtac agctgggaaa 480
actgagaccc aggaggaagg ggcctctccg agatgccaca gtgagtcaag agtcctcact 540
tcagagggct ggagaataat ctactgaggc agggccaggg cacctgtctg agaggggctt 600
ctaaggctgc aagcttttcc ccttccgtgg actgcattca caccttgttc ggtcctgctg 660
gggccggggc tctccttcct tgcccctttt ccttggcact ctttccacag gccctgtgtg 720
gtctgggctc taccgagagg tccccaagga gagctggcgt gtcagtcagc caagaagcaa 780
gcaggcaggc aatgccagca tgcaggtggc ggggctggca ggggagccgg caggagggcc 840
ggacacccgg agccggggaa ctgtaatgtt cagggaattt caattggcat tgctgtcccg 900
ttccagccaa ctggctaacg gtgccgagtt tgaatcagtg acccgcctcc tggtccctcc 960
tccttagccg gcctctctcc ctccctcctt ttttccctcc ctcggtggcc ttccaggagg 1020
cgggaggcgc ccgctgtcga ggcagctgag ccccggcaac cgctgctctc cgcctctccc 1080
ctcgcggggc cggctcatgg agcgcaggga ccgggctggc tctcgccgag ccccgggcct 1140
cttttagcct cgtccccaga gagggaggag ccggtgcccg gcacagcccc gccggcccta 1200
<210>100
<211>1200
<212>DNA
<213>智人
<400>100
aacaattcaa aactggaagc agtccaaaca cctattaaaa ggtagataaa caaattgtgt 60
tatattcatg cagtggaata gtaacagcaa taaaacccaa caaactcttg acacatagga 120
cgaaatttat caatcaaaat aattatgcta ttggaaagaa gctagattaa atgttcatac 180
tgtatgattc tattatcgta aaattctaga aaatgcaaac taatatatgg tgacagaaag 240
cagaacggga gctgggagga gtcaggtatt acaaccgggc atgaggaaac tttgaggtga 300
tggaaaagtt tatcttaatt gtggaggtga tttcaacagt gtatacatat gttcaccctt 360
aacaaattat gcacttttga tatctgcagt ttattgtact ttaaccttca agctgttaaa 420
aattaaccgg agataatttt caattgttgt gtaaggtttg ccacaaagtg taatatctgc 480
aaagaagcag acaactaatt ttttcttctt aagattgtgg aaaaagttgt aatactacag 540
agagctgtgg aatctaagga ttagttgacc aacgcttgta aagctaccaa tctgaaaaac 600
acattttcag ttaccaaagt tattttctct cttccatcgt gtaaatagaa tgtcggggtt 660
cttctaattt gggtgtttct aaaatttaaa tccacgtgaa cagattagga aagaccacga 720
aatcctacgt cacctctaaa gtcacagctt gaagccttgc gaaaggaact ggccctagac 780
cccaccccgg cctataaatc accagggcgc agcctcagtg cctgggggtc ggcagcagcc 840
agcgtcaggc ggctcccgca cgcttcttcc taggcggcag gccgtggctg ccacgtgact 900
cccgctaaca ccggatgatg gcgcagcgct gtgcacgcag gcgcagtgtg gggcccttgc 960
ggtcgaagct cacgcggtaa gccgctgcac gtgtgctacg gcgggcggag ggccgaaagt 1020
ccagtatgtg ggtccagggt cactcttcta gagcttccgc aacggaaagt gtgaggtcag 1080
tagtagtttt tgtggtacgt gcagtggtgg ccgcttcaag gactattttc gtcgctgctt 1140
gcgttttaag tctccaatcc tgggacgagg cccatttcag ggttttctgt caccttctag 1200
<210>101
<211>1200
<212>DNA
<213>智人
<400>101
catcctcatg tcgtgtcccg ccagcaacta taatttcccc gcgtgactga gcgccctgct 60
agagttgccc agatttagcc agaatctggc agaggcggcc ccaaaatttg gaactcccag 120
gcctcagggg ccacctctcc agcactgcgc gcttggagtc ggggtggaca ctgtcattct 180
ctctcatcga ttgattgatt gagacgaagt ctcactctgt cgcccaggct ggagtgcagt 240
ggggccatct cagctcactg caacctccgc ctcccgggtt gaagcgattc ttctgcctca 300
gcctcctgag taactgagat cataggcacc cgccaccgcg cccggctaat tttgtatttt 360
tagtagagac ggggtttcac catgttggcc aggctggtct caaactcctg acctcaggtg 420
atccacccac ctcggcctcc caaagtgatg ggattacagg catgagccac agcgcccggc 480
catttctgtt gttgtttttt ttttttgaga cgaagtttca ctcttgtcac ccaggctgga 540
gtgcagtggc tgcgatcttg gctcactgtg acctctgtct cccgggttca agcgattctc 600
ctgcctcagc ctcctgagca gctgggacta caggcacgtg ccaccacgcc cggttaattt 660
tgtttttttt tttcagtaga gacggggttt catcatgttg gccaggctgg tcttgaactc 720
ctgacctcag gtgatctgcc tgcctcaacc ttccaaagtg ctgggatttc aggcgtgagc 780
taccgtgctt ggcctattta ttttattatt ttttaacaaa tgtcattatc ttcttaactt 840
ttggcccccc aaataaatga ggaaactgtt aaaattgtat tcaacaatcc ttgttcgata 900
tctcctttga tatttaaact tttaccagtg tattaaaatg atgtctttgc attcagaagg 960
ttaaagaaat ttgtttttta aagtcaggaa gcatctaaat atggtgtcct ccggaaaaaa 1020
gtattccagg aaatctggga agccgtctgt ggaagatcag tttacgagag cctatgactt 1080
tgagactgaa gataagaaag atctgagtgg atcagaggaa gatgttattg aaggtgcagt 1140
acatctcatg ttgggcagtg atgtccttca gttcatttgt tttgaaccca ttgagactat 1200
<210>102
<211>1200
<212>DNA
<213>智人
<400>102
aaaaaggctt agaggagttt gtgtgctcaa ggtcattacg ttagttaatg gagaagatag 60
gattcaaact cagctgtcta cacaaccatc tataatgagt attctgtaaa tatttaataa 120
gtgaatttct ctacacacat tgcttgtatc tttgctggaa cacaaggagt gcagtaaata 180
cttaaagata gtgaagtcag ggaaagccag gagggcttgt aactaatcgc acatcgctgg 240
tgtgaccagg tgtttcaatg ccaaagcagt taaaatgtgt cttgtcaaca tcatttgaga 300
tttttagtat ctattattca cttttaacca tggcttgttt tgctgttctt actgattttt 360
ttagatccaa gacaaaataa aagaagttga gcagagcaag gccacgagcc aggaactcag 420
ccggcaaatt cagaagttag ctaaagacct cacaactatt ctaactaagc tgaaagcgaa 480
gacagataat gtagttcaag ctaaaactga ccaaaaggta agaagtagaa ttttaaaggg 540
tactactgaa tgaattaaat agtttttgga gtcagtttta cttggggata taggataaaa 600
accttttagg aacctttttt aaaaccaaat agtaacagca ggtggtaaag aaattttgta 660
actgaagcaa cacagatcct cttacataat tgatcattat aattgaacag tattaataaa 720
tatacatgca tgagtgtgta cgaaagaaga gcgtcaaagg actaagtgat gatttaggaa 780
tacaagtata taaattccaa actgaattgt gtccttggta gctaaatctg tgttcttcct 840
ctgttgatga gttcagggac tctaatcctt tttgggtggg gcagaaggaa aatgttagcc 900
ttctcactca gcctcatagg aaataaacac cagcattaca acatatcctg ccctgccttt 960
ccaaccgaag aaacaaaaat gacctgatca tagtagaatt atagtagaat tattcattat 1020
aatatttggc tttgacaaaa atcagtctga tctcgggaaa cctggagaaa tttattttct 1080
gtactctaat gttctttcat tttggtgacc atcaaggtgc tgggagagga attagatggc 1140
tgtaattcaa agttaatgga attagatgca gcagtacaga aattcttgga acagaatggc 1200
<210>103
<211>1200
<212>DNA
<213>智人
<400>103
agggctgacc tggaataatt atgctctggt ggttgtctcc acaaggggct ctgggggtgc 60
cccaggattg ttgccctcag gcagaggcag ggcatacatt gagagtgatc ccaaacactc 120
ctcctccagg cccaactttt ggaggtagca agttctgcaa atagagatcc attgtttggt 180
ttctctctct aaaaaaaaac aaaagtcagc acaaagaaga ggaacacatc agattggttt 240
accagatttg tttcagatgt tattattttg acacgatcca gaagaaggag aatttgaaga 300
aaatggaaag ctaggcagtg ggaatgttgg cagcaggtaa gggaaaggca ggcagcaaag 360
agaaacttca tctactttat aaactgctcc ttcctttcag caaatttaga ggataaatga 420
ctgttttgtt cagattggag attcaagggg gggattatta cttttaagat tattgcaaca 480
tggcttcgat tattttagct gcaatcatcc tgttggactt ggacttcact gttggtgaag 540
agagactgtg tttgactttg cctggatacc ataaaaccac aacaaaataa attctcctga 600
atgctaccag gcaacaccaa gatctcttac accacgagaa ggacttgtgg ccaaagatac 660
aaatggctcc gcaatgtaca gggtgcatac agtgcacctg aagaacctaa aagtggtttt 720
tagaatcatc ataataaaca gtcaagaatt aaagatgtca agcgctttct caagaagtct 780
aaactttata cataacatta aaaaagatct ataaagcctg accagtctcc ctcaaattaa 840
gttatttgct actgacttgg cagccaaaac gatttaggat ctttcggaag ttgatgaaaa 900
aggagccagc gggttttgct ctttgctctg catcacgccc ttcctgggac catcagggaa 960
cctcccagcc tttcaggata ggttccgctc agaaaggtca cccgggcagt ggaaaccgtg 1020
ggcaaaagtt agctggcagg acagcgcagc tcctccaggc agcggaggca gcgcgtcccg 1080
gctctcaggg acatttcctt cccacctcga cccccgggag gtggtcccgg tataaaggct 1140
cgctgagcgg gtgggtcaca gcacagcttt gcagctgcgg agaaacgccc aaggccgtgc 1200
<210>104
<211>1200
<212>DNA
<213>智人
<400>104
atatttatta acatcacatt taatcttctc actgtgttac ctatggggta ttccctgcac 60
ttgtttgaaa ttttctaatc aaaagggtat ttcaaaatat attgtaatat gattgattta 120
ctttagatgg caagcaaata ccactttata atagtctgca tgcattcaaa gtaaaataac 180
agtagaaagc ctaatctctt ttgccattaa aggtttcaat ttgtcatgct cagttttaag 240
cttttaaaaa ccaacatatc cagaaaggca aaaaatacta aaatcatttc atagcagtaa 300
ttacattttc ctttggatca tgtgccttta aaacgtctga atgcattgct gtgcaagtgt 360
catgtgtgtt taaaagatgc ataattatta gatgcagttc cagcatagtg ttttaagtac 420
aagcacccag ctcctattca aggtaagagc ctttgacagg caccaagctg cctctgaatg 480
tggcagcggg atcaaattgt tgaatacatt gactcatcgg tgcgggctgg aaattatgct 540
tcttagccct ctgtgaaaca tgtttttcat tttttatttt tttttaaact gtatcttagg 600
atctgcttca aaacacggat gcccacaaaa gagcattcca tgaaatctac cggaccaggt 660
ctgttaacgg gattccagtg ccacctgatc aattagagga catggccgag aggtaagaga 720
atatctgcat ttaaaggaag tctcttttta aaacactagg tggacgcttt ttatatttct 780
tttatttttt catgattttt ttttaacaga ggcgcctacc tttggtaaat agaaagcggg 840
ctcccataag acatgctaag aatgccacca ttctaatgta ttattaactg aaaagagtga 900
ctctgaattt atccacagcc tagaaatcac agaaatggtt tcttcagagg ctgtattttt 960
gttcagtact gtaaggaaca ttatgtaata ttgcaaaaac agcttataaa agaaacagac 1020
gagagatgtg ttggcagggg aaagaactaa atcgaagact tcaatcattc atgctttgct 1080
tttaaatcca gagctagaaa aggaatcgga tttccagaaa atgatcagcc agagttagaa 1140
gagcttgtgg ctgcattcta tttaaggctg acatgtaaca ggttaagtaa gcatcagttc 1200
<210>105
<211>1200
<212>DNA
<213>智人
<400>105
attcaatgtc tcccacttta taatagcaaa tcctagactt caggaaacag tgggctaaaa 60
agatgtatga ctatcattca ttttagtcct agtttatttg ctattttcct tggagtgtgg 120
tcttctctct gataatcatt ttgcctattc tcccatttta aacttttcag ctctccttaa 180
ggcggcagca aataggtgaa agattgaatg aatgggcagt cttcagtgaa aagaacaagg 240
aactctgtga gtggttgact caaatggaaa gcaaagtttc tcagaatgga gacattctca 300
ttgaagaaat gatagagaag ctcaagaagg tatggaatgc atggctactt aggttttcat 360
tcttcataag gcttatgtgt acttttcaca ggtacagaag gtggctttac tcacaattac 420
tttcctgtca aaggagcagt atattttaaa cattttatct ttttaatata aaataaactt 480
gcagctgggc gcagtggctc acgcctgtaa tcccagcact ttgggaggct gaggtgggca 540
gatcatgagg tcaggagatc aagaccatcc tggccaacat ggtgaaaccc tgtctctact 600
aaaatacaaa acattagcct ggcgtggtgg tgcgcgcctg tagtaccagc tactctagag 660
gctgaggcag gggaatcact tgaacccaga aggcggagat tgcagtgagc cgagatcgtg 720
ccactgcact ccagcctggt gacagaacga gactctgtct caaaaaaaaa aaaaaaaaaa 780
aaaaaaaaaa aggatatcca gcataaaata aacttgcata aaaaggcctg ctttacacat 840
aaaatatata gaatacttgc aatttgtgat gaaatagagc atctactatt cagttcagta 900
tttgggggtc ttaattacct gttcagtagg aaccctttat atgtattatt tttctttcct 960
tttttttttg ttttttgtgt attttttttt gttttaaaaa ggtaaagcca ctagagagaa 1020
actgaaagaa aacattctta agataaattg aattgacatt ttctctctaa aatatgattt 1080
atagaccaca gataggaatt aagagtttcc tgataatttt ggcttcatat tattttaaag 1140
gtatgtatat cttatcaaat tattttacat attcatttgg atccaaaaca tttctgatgt 1200
<210>106
<211>1200
<212>DNA
<213>智人
<400>106
tgaccttgtg atccaccaac ctcagcctcc caaagtgctg ggattacagg cgtgagccac 60
caatgtattt cttttattaa gaaaatgtgt ttcctgtagt gttctgtttt aaaaacagtc 120
aactcacatg accagaacca gatgctttgt tttattttag ttacaaatca tcatgtagtc 180
ctttttggaa agaacttagc aaattttcat tatttattta atatttatta tttatttgtg 240
tgtagttttt aatcccctaa aggatgtaaa gcatccagca ttaatcatat tttattgaat 300
tataggaatt aataatttgg ggacttattt tctttaaaag tataaattat taaattatca 360
tctgcttagt gcagaaagtt tggaaactct tgaaattcac aaaagaaaaa gagttacctg 420
aagaccccct gagcaaatga atatagttat ttttttaatt gtcttaaaat gaaaatgtta 480
tttttgtcat ctacatgatt atttttaaag gacaaaagtt ttgcatatgt aagggagaat 540
aatatttctt ccttattttt cctccccaaa tagtctactc aaagataaag agcatgtact 600
ttcccacctt cgcaaacaac ccctaaaact cttgcataca ctaccgagct ggcatactga 660
acccaaaaaa gaaggaagtt actccttttg ctactaccat ttgctgtgtt tgtggacatt 720
ttgtttgttt gcagtgggat gatttgtttt ctttaaatag ctttcccagc ataacaaact 780
gcccgcaaga aaagttgact gtccttacag aacagcagag tgtgtgcagc cgatgttgtt 840
tttgctgtcc tttctttaga cctgtagctt cctcctcctt acagattaca ctgagctttt 900
tccccttctt acactcgtgg cctacattcc aggagatcaa gcctggcaca tgttaatgaa 960
tgtaggtttt atttagaaac atgaccactt gtcactgccc agtgtcatgt tatcgggcag 1020
agactaccaa catttgtcta cagtgagcat tttcatactt ctatacacag acaaggggaa 1080
actttcatcc ccacgcagga tatagctttt tgctctgcag agtctaactt ttgcaagtgg 1140
aagcttcatg gtggtggcgg aggacctgag tgccctgagg atggcagagg acagctgtgt 1200
<210>107
<211>1200
<212>DNA
<213>智人
<400>107
tgccttgtct catatttagt tcattggaat acatatatta tgctaacaat aataagcatg 60
aaaaaaattt caaatttttt aactccatga ggtaaactaa ataaggtaaa agaaattaaa 120
ctaaggaaat tatgacaata aaatgttttg aagacttcag gttttttaaa atgttagtca 180
taatcaagaa aaaaacaaag ttgcctatag tggtagattc ataaccaata tatttcttta 240
atcaaagttt aaaatatttt catttctgat tactaaaaat acattaatat aagaagaatg 300
attgttttat aaaagaattc acagtacaat atctttaagt actatgtttt ctagaattta 360
tttcttatat aaaatgcagt tttctttaat tttttatttt tttttttgag attgggtttg 420
cgctgtcacc caggctgtag tgcactggtg cagtaatggc tcactgcagc ctcagcctcc 480
tgggctcaag cagtcttcct cccacttcat tacctgggac tacagatgca tgccactgtg 540
cctggataat cttttgattt tttttttttt ttttttttga gatgaggtgt cactttgtaa 600
cccaggctgg caggtgtatt tccttttttt tttttttttt ttttgagatg gagtctcgct 660
ctgtcaccca ggctggagtg cagtggcgcc atctcagctc actgcaagct ctgcctccca 720
ggttcacgcc attctcctgc ctcagcctcc cgagtagctg ggactacagg tgcccgccac 780
cacgcccagc taattttttg tatttttagt agagacaggg tttcacagtg ttagccagga 840
tggtcttgat ctcctgacct tgtgatccac caacctcagc ctcccaaagt gctgggatta 900
caggcgtgag ccaccaatgt atttctttta ttaagaaaat gtgtttcctg tagtgttctg 960
ttttaaaaac agtcaactca catgaccaga accagatgct ttgttttatt ttagttacaa 1020
atcatcatgt agtccttttt ggaaagaact tagcaaattt tcattattta tttaatattt 1080
attatttatt tgtgtgtagt ttttaatccc ctaaaggatg taaagcatcc agcattaatc 1140
atattttatt gaattatagg aattaataat ttggggactt attttcttta aaagtataaa 1200
<210>108
<211>1200
<212>DNA
<213>智人
<400>108
tgtttgactt tgcctggata ccataaaacc acaacaaaat aaattctcct gaatgctacc 60
aggcaacacc aagatctctt acaccacgag aaggacttgt ggccaaagat acaaatggct 120
ccgcaatgta cagggtgcat acagtgcacc tgaagaacct aaaagtggtt tttagaatca 180
tcataataaa cagtcaagaa ttaaagatgt caagcgcttt ctcaagaagt ctaaacttta 240
tacataacat taaaaaagat ctataaagcc tgaccagtct ccctcaaatt aagttatttg 300
ctactgactt ggcagccaaa acgatttagg atctttcgga agttgatgaa aaaggagcca 360
gcgggttttg ctctttgctc tgcatcacgc ccttcctggg accatcaggg aacctcccag 420
cctttcagga taggttccgc tcagaaaggt cacccgggca gtggaaaccg tgggcaaaag 480
ttagctggca ggacagcgca gctcctccag gcagcggagg cagcgcgtcc cggctctcag 540
ggacatttcc ttcccacctc gacccccggg aggtggtccc ggtataaagg ctcgctgagc 600
gggtgggtca cagcacagct ttgcagctgc ggagaaacgc ccaaggccgt gcatctccag 660
gaggtaggga agcctgcgag cctccgggtc cccgccccca gctcttccag gcaccggcgc 720
atcccggagc cgggcgcggg gcgcggggca cggagccggg gagggggtgt ggcgggccag 780
ggcggtgcag ggaccctgcc cagaggctga accggcctgg gcgaccttcc ttcccgacag 840
gagcagtaga tgcgtggggg agggcgaagg gggaggcctc accccccagc gagcagccgg 900
gaggaggaac cggtcgcgga gggcggggag cgcggctgag cagcccggcg cgggagtgag 960
tgtgggcgag ccagccaggg tgagcgcggg cgccgggccg cggccgccgg ccgcagcggg 1020
ctgagattgt tgtcctctgt caccagggcg gctgggctcc cgcagtcctg cagaccgcgc 1080
ccgatcccgg cgacagggcg ggcggacagc cgcgcatccc cggggtcccg ccgagcctgg 1140
gcgcagagag ccgggaggaa gcgttcgctc gcttcgcctt gctgctggga aactgaacga 1200
<210>109
<211>1200
<212>DNA
<213>智人
<400>109
tgttttattt tagttacaaa tcatcatgta gtcctttttg gaaagaactt agcaaatttt 60
cattatttat ttaatattta ttatttattt gtgtgtagtt tttaatcccc taaaggatgt 120
aaagcatcca gcattaatca tattttattg aattatagga attaataatt tggggactta 180
ttttctttaa aagtataaat tattaaatta tcatctgctt agtgcagaaa gtttggaaac 240
tcttgaaatt cacaaaagaa aaagagttac ctgaagaccc cctgagcaaa tgaatatagt 300
tattttttta attgtcttaa aatgaaaatg ttatttttgt catctacatg attattttta 360
aaggacaaaa gttttgcata tgtaagggag aataatattt cttccttatt tttcctcccc 420
aaatagtcta ctcaaagata aagagcatgt actttcccac cttcgcaaac aacccctaaa 480
actcttgcat acactaccga gctggcatac tgaacccaaa aaagaaggaa gttactcctt 540
ttgctactac catttgctgt gtttgtggac attttgtttg tttgcagtgg gatgatttgt 600
tttctttaaa tagctttccc agcataacaa actgcccgca agaaaagttg actgtcctta 660
cagaacagca gagtgtgtgc agccgatgtt gtttttgctg tcctttcttt agacctgtag 720
cttcctcctc cttacagatt acactgagct ttttcccctt cttacactcg tggcctacat 780
tccaggagat caagcctggc acatgttaat gaatgtaggt tttatttaga aacatgacca 840
cttgtcactg cccagtgtca tgttatcggg cagagactac caacatttgt ctacagtgag 900
cattttcata cttctataca cagacaaggg gaaactttca tccccacgca ggatatagct 960
ttttgctctg cagagtctaa cttttgcaag tggaagcttc atggtggtgg cggaggacct 1020
gagtgccctg aggatggcag aggacagctg tgtggatgca gatctcccag attgtaactg 1080
cgatgtcaca aggcaggcat cttcttgagt ttcttccatt gtacatagct ttcatgttac 1140
g1ggggtttg taggatagac gctggaagcc ttaatccaga actgtttttg ccaatgttac 1200
<210>110
<211>1200
<212>DNA
<213>智人
<400>110
ggagagaccc gaaggggagc ggaggttggg gtagaagccc ccggccctcc tgtattacta 60
ctgcggaatg cgggggaccc cgcagacagc caggctccca ggacggggca cccttggggc 120
ttcagtttcc ctcgcatctc caagctcgct ctgcgggcga tttgccagga gaggggtcca 180
tggagagagc gggagacgag gggcgcccgg ctgaggaata gggcttgcct cctagcgagt 240
gtcgaggtcc ccgggtccgt gcgtcggtct gtccgtccgt ttgtgtgttc tcgcggtgaa 300
cgcgggcgga cccccagtct ctccgggaga aacttgggtc tgcggctggc acgaggtctt 360
tgtgtccggg tgtctctccg gctgcgagtg gttttccgcg tctccgctgg ggggcggggg 420
acagggggcg gggtggggga gggtatgagg gtgttgcggc gtccttcccc caccccctct 480
cgcccctata actcgctccc tccgtccctc tcggactcgg actcggggcc ggtgcgcgac 540
tgagctggcg cctctagccg actttgccaa gagggcgcct cctgcccgat ccgcgctgac 600
cctgcgcggg acgcagcccc aggcggctgc ctagccgagg cgggagcccg agctgagtcg 660
agctcgccgg agcgggtgag tcccgagccc gatccccgcc gggctggacc ctggcgcgca 720
gctgcggcgt ctccggggag tcgcggcagg gggaatggcg tgtcgcgccc tggcggcggg 780
agctgcggga gggtcggcga cgtggcggcc ggcccagggt atttacctgc tgcaccagtg 840
cccggcagcc acgctcgccg gctgccgcgg ggcttctttg tcccgatatc tggagggtcc 900
ggggcgggag ggagtactgg gtcgcgtccc ctccatgggg gaggggctgg gggagtgaga 960
ggcctggaga taatgcggag tgggggtggg gagatcctgc aaggaccagg acgccggggt 1020
tccaggagac tctgcaggct ccatccctcc ttattccccc accccgaccc cagtagcgct 1080
gggcctagga gcactcggga gttgctcagt ggctctgcac cgctggcgcg ggaaggggag 1140
aaaggggctg ccagaggcgg gaatttggtc cccacgcgct gctccaggga cgagaagcca 1200
<210>111
<211>1200
<212>DNA
<213>智人
<400>111
ggggccccac cgccgacagg tgtagatcaa gagactcccg agataggccc ctgcagggcg 60
ctggtccccc ggcctccctg accatggctc acagacttcc agcgctgagt gaggcagctc 120
gaagcctctc agccgatctg ttcctgggcc tcactccaca gtttctgagg ggatctctac 180
tttaagtcta gcctcaatcc tcccgttgag ctttctgtct ttcttgttat gcttagcaga 240
aagatacatg atctctggtg ctgtttcacc gaagcaagga ggtgggtcgg cggaactgag 300
cgccctgcgc cctcttgaaa tgacccccca ttcctgtttg ccagaaactt ttccctcccg 360
ttgccatgga gagagacggc cgctgcctcc cgtcgccata gcaacatgcg ggtaccgcgg 420
accgcaggat tgcggagctc ggaaagtctt gcagttcgca tcgcccgcct gtcttggggt 480
cttctacctc cgaagctggg actcgggggc cagtctaact gctcccgtca ggaacctcgg 540
ccaaggtcct cccagaccct gcctgaccgt cgctctttct gttacggggt tatctatttc 600
tctgtcattc gtgtggcatg tggcagttta cccagtgttt tcacaaacac gatctttcta 660
tccccaggga gtccgtgaag tacttaaaat cattacacct cctttacgga gaggaaaatt 720
gaggctcaga gacgcccaag gtcacaccag gcagtgaatg cggagtggga acccggactc 780
tttcctggcc ttgcaccctc cgagattcgg gacagcccgg cttcccgcct cgaaaccccc 840
accccccgga ctcaggccag tccctgagtg tagagggggc ggccgcgagg cgccagactc 900
gccagctgcc gcgggatgcc acgtgagggg cggggaccct gcggggaagt gattaaaagc 960
agagcggagc cgcagggggc cgctgcaggg agggtcttct tggggccgtc gtgccccgcc 1020
ccagtgcggc cggggcgcgg gttcgagctg ctgctcggca agcctgggtg tctagggcat 1080
gagcggagtg tggggggccg gcgggcctcg gtgccaggag gcgctcgcgg tcctcgcctc 1140
gctgtgccgg gcccggccgc cccctctcgg gctggacgtg gagacttgtc ggagcttcga 1200
<210>112
<211>1200
<212>DNA
<213>智人
<400>112
aactgggaaa gagctggaag atgagacacc aaactccatc ccatggtgatgt ttgaacca 60
ggctggagct ggtttcacat gtttttcatt gtgcatgact ttcttaattg ccttagtggg 120
aatgcgttac tgcaaaataa agtgaaattg ttttccttat tgcttgtaat ttacagaggg 180
gtggttttga tcatataaac caggcacttt tcaaatccat tgatcttagg gtggaaggag 240
ggatttcttt ttaagtattc atttcgaact atgctttcac tagtaaactc aaagcccaag 300
ggcaaaaacc catgattctc cattttgtaa tagctattag atgtccacag cacatcagac 360
ctgtggaaaa cgcatgcttt gtgtatggaa gagggagagg gagcgtcagg agttgtcctt 420
tgccaaaaaa cgtactctga cactcaaagg cacaggctgg tggagatcca gggaacccgg 480
gaaagcccag gcctaactca ggcccgcgcg ggtctcttct gatcccataa gatgaggagt 540
gggtcctggc tctgggcatc ctggtgtcga ctgtgagttc ccagcagagg cccagagtcc 600
cggtccggca gccgagggaa gcgggggggt cttccagaag aagaaagggc caaggtcacc 660
ccggtgcctc tccagcagca gcagagggcg gcggtcggtg tcgctgctgg ccggggcctc 720
gaggaaggcg cgggccagct ggggccgggt ctgcgttccc aggagctgcc accgttccag 780
ggagcaagtc aggccgggac gtagcgcctg cgcgggaccc tcacttgcca ccaagacccc 840
cacaaacccc gccccatcct gccttacgcc ccgccccaag gtcgttctcc cgacccgggg 900
tcccgcccca aggccgtcct cccgccccgc cgcttggtgg cggccgcatg ctgcccggat 960
ataaagggtc ggccccacat cccagggacc agcgagcggc cttgagaggc tctggctctt 1020
gcttcttagg cggcccgagg acgccatggc cgagtgcccg acactcgggg aggcagtcac 1080
cgaccacccg gaccgcctgt gggcctggga gaagttcgtg tatttggacg agaagcagca 1140
cgcctggctg cccttaacca tcgaggtaca gccagctttg gagcggatgg cgaggcagca 1200
<210>113
<211>1200
<212>DNA
<213>智人
<400>113
tctaatctat ggtaatcgaa atgagaagag tgtttgcccc tggcctaagg atggaaggat 60
tgatttagga aaaagtctgc aggagctttc tggagtgatg gaaatgttct aactcttttt 120
tttttcttct tcttcttctt tttcttcgtt tcgagacgga gttccactct gccgcccaga 180
ctggagtgca gtggcgccat ctgggctcac tgcagcctcc gcctcctggg ttcaagccat 240
tctcctgcct cagcctcccg aggggctggg actacaggtg cccgccacca cgcccggcta 300
attttttgtg tttttaatag agacggggtt tcgccatgtt ggccaggcta gtctcgaact 360
cctgatttca ggtgatccac ccgccttggc ctcccaaagt gctgggatta caggcgcgag 420
ctaccgcgcc cagccaaaat gttctaattc tttattggtg gctacacagt tgtcaaaatt 480
tatcaaactg tccacctacg atatattata agcctgtatt aaatgtaaat tagaactcga 540
ttgaaatctg tgtgtataaa tataaatata cacttattta catttctaat ctaatctgaa 600
ggtccattgc aacgaatccc gctccgctct gacccaagaa ctccgcactt tctctccacc 660
agcctttcaa atacctgaac ttcatgcctt caagaggtgg attccggctt ctttacagcg 720
caatcactag caggtcattt ccgtctagct tgcagatttc ccattactga cacaaacgct 780
ccctcagggc gtccccgtct ggactacagg agaaagtttg ggaggcaggt tcaacttttc 840
aacttggcgg ggaattcctc tccctcttac acagtttgca gcgcgggggc ggcggggtga 900
cagtccccgt gcatgaatca gccacccctc aggctccgcc ccggcggggg tcggccggac 960
gctcgccccg cataaagcgg gcacccgggc cgcctggagc agaaagccgc gcacctcctc 1020
ccgccaggcg ctttctcgga cgccttgccc agcgggccgc ccgaccccct gcaccatgga 1080
ccccgctcgc cccctggggc tgtcgattct gctgcttttc ctgacggagg ctgcactggg 1140
cgatgctgct caggagccaa caggtatctg gccgctccag gagcttctct ccccaaccgg 1200
<210>114
<211>1200
<212>DNA
<213>智人
<400>114
tctaatctat ggtaatcgaa atgagaagag tgtttgcccc tggcctaagg atggaaggat 60
tgatttagga aaaagtctgc aggagctttc tggagtgatg gaaatgttct aactcttttt 120
tttttcttct tcttcttctt tttcttcgtt tcgagacgga gttccactct gccgcccaga 180
ctggagtgca gtggcgccat ctgggctcac tgcagcctcc gcctcctggg ttcaagccat 240
tctcctgcct cagcctcccg aggggctggg actacaggtg cccgccacca cgcccggcta 300
attttttgtg tttttaatag agacggggtt tcgccatgtt ggccaggcta gtctcgaact 360
cctgatttca ggtgatccac ccgccttggc ctcccaaagt gctgggatta caggcgcgag 420
ctaccgcgcc cagccaaaat gttctaattc tttattggtg gctacacagt tgtcaaaatt 480
tatcaaactg tccacctacg atatattata agcctgtatt aaatgtaaat tagaactcga 540
ttgaaatctg tgtgtataaa tataaatata cacttattta catttctaat ctaatctgaa 600
ggtccattgc aacgaatccc gctccgctct gacccaagaa ctccgcactt tctctccacc 660
agcctttcaa atacctgaac ttcatgcctt caagaggtgg attccggctt ctttacagcg 720
caatcactag caggtcattt ccgtctagct tgcagatttc ccattactga cacaaacgct 780
ccctcagggc gtccccgtct ggactacagg agaaagtttg ggaggcaggt tcaacttttc 840
aacttggcgg ggaattcctc tccctcttac acagtttgca gcgcgggggc ggcggggtga 900
cagtccccgt gcatgaatca gccacccctc aggctccgcc ccggcggggg tcggccggac 960
gctcgccccg cataaagcgg gcacccgggc cgcctggagc agaaagccgc gcacctcctc 1020
ccgccaggcg ctttctcgga cgccttgccc agcgggccgc ccgaccccct gcaccatgga 1080
ccccgctcgc cccctggggc tgtcgattct gctgcttttc ctgacggagg ctgcactggg 1140
cgatgctgct caggagccaa caggtatctg gccgctccag gagcttctct ccccaaccgg 1200
<210>115
<211>1200
<212>DNA
<213>智人
<400>115
cccaaattgt tctatagatt caaaacattg ccagttaaaa tctcagtgga ctttgttttt 60
ttgaaactga caagctgatt ctgccattta taataatatt caaaggggca agaataacca 120
agacacattt gaagaagaac aaggaggaag aagaacgtat ttgaagaaga ataaggaact 180
ctattaagtg tatatctcct atatattgag atacacattt gaaatacatc tatcacctag 240
atattgagat atattataca tttaatatag tgtgttgctg gtatagggat agacaaatga 300
acattggatc agaatagcac tgaaacaaga tctaccccta tatgggcatg tccctattaa 360
caaaaaaata ttgttgatta tttcctcaag atgatctgta aaaaacaagt taattgaaca 420
tccatatggg aaaaaagtga atccttctgc tacctcaaat atcaacccca ggtagattat 480
agatctaaaa gtgaaaggca aagcaataaa gattttagaa aataacaaag agaatatctt 540
tatgaaaata caggaaatat tttaaaaata ggctagaaaa ctcactatta aaatatataa 600
aatataagaa catctgttca tcaaaagtac tatagtttga atagcagtgt ctcctccaaa 660
attcatattg aaacttaatc cccattgtaa cagtactaat cctaaaacta agtattaaga 720
ggtgtgacct gtgggaagtg actaagtcat gaggggtctt tcctcaggta tgggattagc 780
atccttataa aaggccttga gatggaatgt agtgccccct tgccctcttg cgttctccca 840
tgtgaggaca cagcaacaag gcaccatctt ggaaggagag agaagccctc accagacaac 900
agtgcacatg ccttgatctt agacttccca gcctccagag ctataataaa tacatttctg 960
ttctttataa attacttggt ctctggtatt ttgttacaga agcactaatg gactaagaca 1020
aaaagattcc attatgaaag tgaaaaggca accgcagagt ggcagaagct tttggagatg 1080
atgaatatgt ttacttcctg gattgcggtg atgataccat gagtgtatac atatgtgtgt 1140
atacataatg tatacaaatt gtgttcattg attatgtaca gtttctttgt ataccaatta 1200
<210>116
<211>1200
<212>DNA
<213>智人
<400>116
gggaaagtct ggaagaacac actcttctgg atctaatcta agttttctca ctacccacct 60
atcatgagta cctttttcag tctctctagg ccaagggttt cttatttaaa aggaccaaga 120
gactccttga tccctaagat tcctgctaag attctgtacc tctttcctcc caaaagaatg 180
actggtcttg aattctaaaa tgcaattttt gtgagtgtgt tttaaaaaga agactgcatt 240
tcgctgaaaa atcttccttg gaaagtatat aaatcttatt agacgccttt gagagtcatt 300
aaaagaactg aagcatcatg cacgtttaaa acattaccag gctggatgga gtacgaaggc 360
actcagggga aggtacttaa acctccgtag gttcaaccaa gtcttaccgg gagtaaccca 420
acgaacaagt gatgcttttt gagacaaatt tggagagttg gctgcaggaa aattaacaag 480
ccagtggatt tccttttccc ttccttagga aacttgtttc tgtagatgca aaaagggccc 540
tagatcctct ggaagagaaa gagagtgggg aggggaagtt tctctttctt tactccccac 600
ctgcggtctg tctgatttcc tctccagctc tgtctgataa ggaattgatt ctccccctcc 660
tcttccccct cccgccctcc ctctccttct ccctgagtaa cgatgctgtc ctagcaagtg 720
atgctgtcgg agacaggaga cgggcgccga ggaggcatcg ccgccgccgc ggggctggag 780
agcctctccc agcaccagag ccccgctcgg ccccgggctt cctcgtcgca gccacggccg 840
cggcagctgc tcccacggtt tgatggtggg cggcggcagc tcggcttcgg cgctagcctc 900
taactgctgg atcgcgggcc gcgacgctct ccgctcctgc cttcccgccc tgggccgccc 960
ggggccccgg aagccgcggg aggtggtgaa ggggcgccgc gggaagactg cactgccgcg 1020
aaggcggagg aggccggcag ccggcacccc cacactcgga ccgcagccgg cgcgatgtcc 1080
accaaggtca ggaagtgcaa agaacaagca agggtgacct tcccggcgcc ggaggaggag 1140
gaagacgagg gcgaggacga gggcgcggag ccgcagcgcc gccgccgggg ctggaggggc 1200
<210>117
<211>1200
<212>DNA
<213>智人
<400>117
tctccaactc ctaggctcaa ctgatcctcc cgtctccgcc tctcaaagtg ctaggattac 60
aggtgtgagg cactgtgccc aggtgagagg taagatttct taaacagagc agaaaaacac 120
taaggtaaag gggaaaatga caaattggca catattaaga tgaaaaactt ttgttcttca 180
aaaggtacca ttaagatggt gaaaaagtag gccaggtacg gttgctcatg cctgtaatcc 240
cagcactttg ggaggccaag atgggcggat cacctgaggc caggagttca gaccagcctg 300
gccaacatgg caaaaccatg tcttgactaa aaatacaaaa caaaacaaaa caaaacaaac 360
aaacaaaaaa accgggcatg gtggtgggcg cctgtaatcc cggctacttg ggaggctgaa 420
gcaggagaat cgcttgaact tgggaggcgg cagcttcagt gagctgagat catgccattg 480
tactccagcc tcggcgacag cgaaactacg agtccaaaag aaaagtaacc ccacagagtg 540
ggaggaaata tttgtaatac ctatactgga agagaaatat ttgtaatacc tatactggaa 600
gaatgactga ctagtatcta gcatgtacaa aggcttccta caaatccata tgaaaaataa 660
cgtcagccca gtagagaaat agggagaagc ctcggatact gcacaagaga gaatatccta 720
gtggccaaca aacacatgag aaggttctca gctcattaga ctttggctaa atgcaaatta 780
aaaccaccat gtaatatcat tactcatcca gcacgatggc taaaataaca aagacgtaaa 840
gacaccacca cagactcgcg agactgagga gtgagtgtcg cgagactgag gggtgggtgt 900
cgcgagactg aagagtgggc ggcgcaaatg ggcgaggtgt ttactcgcca ttttgtgtga 960
ggaacgttga cgctacctac ctctggcctg gcctctaccc actgctgccc tggccgctac 1020
caacatgagc ctcccggaga gtcctcacag ccccgctact ctcgactatg ctctggaaga 1080
cccgcaccag ggccagaggt cccgagaaaa gagcaaggcg acagaggtaa tggcagatat 1140
gtttgatggc cgcttggagc caatcgtgtt cccaccgccc cggcttccag aggagggggt 1200
<210>118
<211>1200
<212>DNA
<213>智人
<400>118
atctgttaac ctcaacttcc taaatagaag gtctattctt ttaccatcat cattattctc 60
ttcggtgcct atttttaaaa aatactcaac cttcttgctt ccttcgctac ctaagtattt 120
ctgcaagccc actttgttct gcagcttagc tttcctggca caattcttat agattttggt 180
cccttttaaa attcattctt cagcaaatgc tttctctctc catcttttga ctagagatca 240
ttagagatca cctgagatca ttagagaaca gtggtttcct tggttgccat tccctttctt 300
cttcattggg agtattctgc ggtgaactca gacattttat ttttcaaagc ttcccattct 360
tttaaaaatg cttttccttt tacagcctct cgctcaaaat catacccatc ttttccctgg 420
atctgttttc tcaagtctcc aatcgcctgc cttctttgtg tcttgtatta ccctcacatc 480
ccccagcttt ctactgctct cccaggacca accatttctt ccgcgggagt cacattacat 540
cagcattcct aatgcagtat ctgttatcta ccagattctg ttttattcta ggtagtcact 600
taaaaacgaa cctcggtact ggtctgactt aacatggagg aggaattgtc taaggttaaa 660
cgcaaactgc tgagagattt ggggcggggg gcacacattt acattcattc gtattaaata 720
tatacctgtt gaatttgtgc tttttctcaa atgcttcaga gactcgagct ttagagtaat 780
tgggatggtg aaaggatggg tttccagaaa cttcgcccaa aattaaagac tccatcaaaa 840
ggactgctcc atacactcaa ggaacaccca ccaacaaatc ccgtctccac aaccaccaga 900
ttatctcacc ggcgagtgag actgcaaggt ttgggggccc ggccgtacca ctccgcgctg 960
cgcacggggg gttcgtaccc atctggccgc gaccgtccgt ttccccctcg cttggttctg 1020
cccctgctcc ccctgcacag gcctcacagt gcgtctggcc ggcgctttat agctgcagcc 1080
tgggcggctc cgctagctgt ttttcgtctt ccctaggcta tttctgccgg gcgctccgcg 1140
aagatgcagc tcaagccgat ggagatcaac cccgaggtga gcgccaggtg caccgctacc 1200
<210>119
<211>1200
<212>DNA
<213>智人
<400>119
aaaatactca accttcttgc ttccttcgct acctaagtat ttctgcaagc ccactttgtt 60
ctgcagctta gctttcctgg cacaattctt atagattttg gtccctttta aaattcattc 120
ttcagcaaat gctttctctc tccatctttt gactagagat cattagagat cacctgagat 180
cattagagaa cagtggtttc cttggttgcc attccctttc ttcttcattg ggagtattct 240
gcggtgaact cagacatttt atttttcaaa gcttcccatt cttttaaaaa tgcttttcct 300
tttacagcct ctcgctcaaa atcataccca tcttttccct ggatctgttt tctcaagtct 360
ccaatcgcct gccttctttg tgtcttgtat taccctcaca tcccccagct ttctactgct 420
ctcccaggac caaccatttc ttccgcggga gtcacattac atcagcattc ctaatgcagt 480
atctgttatc taccagattc tgttttattc taggtagtca cttaaaaacg aacctcggta 540
ctggtctgac ttaacatgga ggaggaattg tctaaggtta aacgcaaact gctgagagat 600
ttggggcggg gggcacacat ttacattcat tcgtattaaa tatatacctg ttgaatttgt 660
gctttttctc aaatgcttca gagactcgag ctttagagta attgggatgg tgaaaggatg 720
ggtttccaga aacttcgccc aaaattaaag actccatcaa aaggactgct ccatacactc 780
aaggaacacc caccaacaaa tcccgtctcc acaaccacca gattatctca ccggcgagtg 840
agactgcaag gtttgggggc ccggccgtac cactccgcgc tgcgcacggg gggttcgtac 900
ccatctggcc gcgaccgtcc gtttccccct cgcttggttc tgcccctgct ccccctgcac 960
aggcctcaca gtgcgtctgg ccggcgcttt atagctgcag cctgggcggc tccgctagct 1020
gtttttcgtc ttccctaggc tatttctgcc gggcgctccg cgaagatgca gctcaagccg 1080
atggagatca accccgaggt gagcgccagg tgcaccgcta cccggagagc gcgaggccga 1140
gggaggggga gccgagtcgc tgatcggttc ggttttgcct ttttctttgc atttgccttt 1200
<210>120
<211>1200
<212>DNA
<213>智人
<400>120
aaatactcaa ccttcttgct tccttcgcta cctaagtatt tctgcaagcc cactttgttc 60
tgcagcttag ctttcctggc acaattctta tagattttgg tcccttttaa aattcattct 120
tcagcaaatg ctttctctct ccatcttttg actagagatc attagagatc acctgagatc 180
attagagaac agtggtttcc ttggttgcca ttccctttct tcttcattgg gagtattctg 240
cggtgaactc agacatttta tttttcaaag cttcccattc ttttaaaaat gcttttcctt 300
ttacagcctc tcgctcaaaa tcatacccat cttttccctg gatctgtttt ctcaagtctc 360
caatcgcctg ccttctttgt gtcttgtatt accctcacat cccccagctt tctactgctc 420
tcccaggacc aaccatttct tccgcgggag tcacattaca tcagcattcc taatgcagta 480
tctgttatct accagattct gttttattct aggtagtcac ttaaaaacga acctcggtac 540
tggtctgact taacatggag gaggaattgt ctaaggttaa acgcaaactg ctgagagatt 600
tggggcgggg ggcacacatt tacattcatt cgtattaaat atatacctgt tgaatttgtg 660
ctttttctca aatgcttcag agactcgagc tttagagtaa ttgggatggt gaaaggatgg 720
gtttccagaa acttcgccca aaattaaaga ctccatcaaa aggactgctc catacactca 780
aggaacaccc accaacaaat cccgtctcca caaccaccag attatctcac cggcgagtga 840
gactgcaagg tttgggggcc cggccgtacc actccgcgct gcgcacgggg ggttcgtacc 900
catctggccg cgaccgtccg tttccccctc gcttggttct gcccctgctc cccctgcaca 960
ggcctcacag tgcgtctggc cggcgcttta tagctgcagc ctgggcggct ccgctagctg 1020
tttttcgtct tccctaggct atttctgccg ggcgctccgc gaagatgcag ctcaagccga 1080
tggagatcaa ccccgaggtg agcgccaggt gcaccgctac ccggagagcg cgaggccgag 1140
ggagggggag ccgagtcgct gatcggttcg gttttgcctt tttctttgca tttgcctttc 1200
<210>121
<211>1200
<212>DNA
<213>智人
<400>121
tgcttccttc gctacctaag tatttctgca agcccacttt gttctgcagc ttagctttcc 60
tggcacaatt cttatagatt ttggtccctt ttaaaattca ttcttcagca aatgctttct 120
ctctccatct tttgactaga gatcattaga gatcacctga gatcattaga gaacagtggt 180
ttccttggtt gccattccct ttcttcttca ttgggagtat tctgcggtga actcagacat 240
tttatttttc aaagcttccc attcttttaa aaatgctttt ccttttacag cctctcgctc 300
aaaatcatac ccatcttttc cctggatctg ttttctcaag tctccaatcg cctgccttct 360
ttgtgtcttg tattaccctc acatccccca gctttctact gctctcccag gaccaaccat 420
ttcttccgcg ggagtcacat tacatcagca ttcctaatgc agtatctgtt atctaccaga 480
ttctgtttta ttctaggtag tcacttaaaa acgaacctcg gtactggtct gacttaacat 540
ggaggaggaa ttgtctaagg ttaaacgcaa actgctgaga gatttggggc ggggggcaca 600
catttacatt cattcgtatt aaatatatac ctgttgaatt tgtgcttttt ctcaaatgct 660
tcagagactc gagctttaga gtaattggga tggtgaaagg atgggtttcc agaaacttcg 720
cccaaaatta aagactccat caaaaggact gctccataca ctcaaggaac acccaccaac 780
aaatcccgtc tccacaacca ccagattatc tcaccggcga gtgagactgc aaggtttggg 840
ggcccggccg taccactccg cgctgcgcac ggggggttcg tacccatctg gccgcgaccg 900
tccgtttccc cctcgcttgg ttctgcccct gctccccctg cacaggcctc acagtgcgtc 960
tggccggcgc tttatagctg cagcctgggc ggctccgcta gctgtttttc gtcttcccta 1020
ggctatttct gccgggcgct ccgcgaagat gcagctcaag ccgatggaga tcaaccccga 1080
ggtgagcgcc aggtgcaccg ctacccggag agcgcgaggc cgagggaggg ggagccgagt 1140
cgctgatcgg ttcggttttg cctttttctt tgcatttgcc tttcagatgc tgaacaaagt 1200
<210>122
<211>1200
<212>DNA
<213>智人
<400>122
ccccagtcta gaaagaacct ggcgtgtagc aggatgcaac atatacttgt agaatgaata 60
aaaaggtaat aaaataacac gagctcacat agcggccagc atttgctgtg caccataatc 120
cgtgctaagc actttgcatg cgttatttaa tttgaatttc ataacagtat tacataagaa 180
aacaataggg ccaggcatgg tggctcacgc ctgtaatccc agcactttgg gaggccgagg 240
caggcggatc acgaagtcgg gagctccaga ccagcctgac caacatggtg aaaccccatt 300
tctactaaaa ctagaaaaag tagccaggcg tggtggcgtg cgcctgtaat cccagctact 360
tgggaggctg aggcaggaga attgcttgaa cccgggaggt ggaggttgca atgagctaag 420
attgcaccac tgcactccag cctgggcgac agagtgagac tccgtctcca aaaaaaaaga 480
agaaaaagaa aagacagtat tttgctccct caccgccttc aggcttttaa ccaactgcca 540
cttaccaccc tagtgaaggt ttgcccgagt gccctattta atattgcagg cttctgtttc 600
ctaccagccc ctttgcttac tctttcacac ttagtcacct tctaacgtgg catacattgc 660
ttattttcta tgctcatgag tatgtctact ccatggaggc atagatgttt gtatgcctgt 720
ttactgatgg atcacaaact gtgtagccta aaatagagct agcacatagt cccacccaac 780
acgtgtcagg tgagcaatta gatatagagg gttccaataa cttgtgggga cacccagata 840
agatctgttt atgactcatg tcttacacag agctcattct tggtctcttg gttagtttat 900
cagagaagac aaatgtatta ttggaaaatg tgtcttaggt cattttttga cagtggctct 960
aatactggaa tctattttaa ctaaaggtta ttatcataaa gcaggtgttt gctgaagaca 1020
gcttactcag atcactactg cctggaggtg gttgatatat cctggtgtaa accttcaaga 1080
agggcacagg caggaaaaca tgagccagca actgaagaaa cgggcaaaga caagacacca 1140
gaaaggcctg ggtggaagag cccccagtgg ggctaagccc aggcaaggca agtcaagcca 1200
<210>123
<211>1200
<212>DNA
<213>智人
<400>123
cctagctccc ctttctgtca gttttttaat tttatatttg ttttcaaatg agtcctcaca 60
ttgattttaa aaatttaaca agagtatagt gaaaaggaag ttcccctttc actatttatc 120
ttccccatat gcatctatta tgacgggttt cttttttaaa ctacttggag tactcataac 180
tgattttgta ctctagttca gaagaaatgt ctgaatgtta aatgtttaca taaaaaatgc 240
tattttatta tatcagtaat ggagcttccc ccctttaaaa ctgctgcacc aggaagatac 300
aaccttgtta tcacaattta aagagaaaat gagacttgga ggttcagatt cctccacagt 360
catagtatca gctacccacg cagtgaccca cattcaggtg attacacaca ctcatacaca 420
gatccataca cgatcttgcc ccccccacct ccacacactc aatatgacct ccccacgccc 480
aaagctgcac acatcttgac ctcacttctc tcacacacac accaatctga cccgcacgcg 540
gtttctttca ctcaactacc cagacacccc tcatcccacc agcacaagca ggcccaccgc 600
ggtctcacac acactcgagc cttcctttgc ccagtctcac atgcatgact gggatcgcgg 660
atttgtcccc ttccgactcc ccatgctggt tcggtcccag acgctcaggt gccacattgg 720
ggtgcgctct cccggctcct ccacacgcta cgcagctgcc cgcctcaaga gcgtctgcgt 780
gcttccagcg ttaagtggaa ttccaagcag cctccggggc acagttagtc tggtcactgc 840
ggccagactg ccgcctcagg acccagagaa cgcagcacac tttagttggg cccatctatc 900
cccggcgagg cttggactac gtttcccagg agaccctgcg gtccagtatg tctcccgagg 960
aggggcggaa gcccgggagc cgccctctga ggctgggcgg ggtgaaagaa agcttgcccc 1020
agaggactta aacaggcaag aaggacttgg ttaaagacta ttgcaatagt caacttccaa 1080
tacaacagca gctggagatt tatagctaac gggctgggtg aaggagttaa aggatgctaa 1140
attactaaga ggaagttaag tatcaagagt ggggggattg ttactaaact ggcttagctg 1200
<210>124
<211>1200
<212>DNA
<213>智人
<400>124
acattgcctc ctgtcttgtc ttccctttcc tcttatgtta aaaccagatt ctgttcctct 60
gctgtagccc ttactgagct ccatcttctc tcaatgttat catcatagaa tttggaggca 120
aacttatttc ttaaatggca taaacaaacc acattctaac cacagatgaa tcttccctct 180
ccatagctca ttccatactc atttagcaca ttagtctttc attgggaaac tgctctttgt 240
ggattatctt tcttttctgt ctccatcagt ttatatgcaa attatgttta ttactgaaac 300
atcccagatt tcccacccca ggaaaaatgt agtactccca acaaccctga taaatgaata 360
tgagaattac tctcatttat aaatgtttat agcactagat tcatctctta aaaaattaag 420
acagggccag gacatctgta taattaccaa gctttcaaag tctgcaggac ttttaaacta 480
aactaaacta ctatttaaaa ctactatttt aaataaatat ctaaactact atttaaaaat 540
aatctgtttc ctgaaaacct cctccacttt ctagtctgac ttttactcat tttctctgct 600
tccctaatct gtttttcaaa ttgcccagtc atatgtgaga actgtataaa ccactcaatt 660
tttatgaaaa ttaaattgta gttaagtctt tcgtatctat tataaacgtt taatctctcc 720
cagaacacaa aaaagtgaat gtttgctttt atattttctt tcagactatg aatcaaagtt 780
gagaccaaga aattatttct gaaaaaggat atggaaaacc ttacaaaaca cagcattgag 840
tgttcaagtt tcagaggtga ttgggaatgt aaaaaccagt ttgagagaaa acagggatct 900
caggaaggac atttcagtga aatgatattt actcctgaag acatgcccac tttcagtatc 960
cagcatcaga gaattcatac tgatgagaaa ctccttgaat gtaaggaatg tgggaaggat 1020
tttagttttg tatcagtcct tgttcgacat cagcgaattc atactggtga gaaaccttat 1080
gaatgcaaag aatgtggcaa ggcctttggt agtggtgcaa accttgctta ccatcaaaga 1140
attcatactg gtgagaagcc ttttgaatgt aaagaatgtg ggaaggcctt tggtagtggc 1200
<210>125
<211>1200
<212>DNA
<213>智人
<400>125
ggccgttatg aagaggaaga agtactgtgt catctattgt cctggggacc tgtcaacagg 60
aacaatagat agacatcacc aggggtgtat ttctgttcaa cacaaggaaa agtttctaat 120
tggagctgtc cagcatgaaa tggactaagc agtgcatttt ctttctccga tcctgactcc 180
actgtgacgg gcactgcaga ctagagagat tgtgtcctag tatgaattta ggttggataa 240
atgatactta gggataaaga gaggaaagga atatcagaat ctccaagaag ctgatacatt 300
ttgaaaaaat atataaaatg ccacacttca ggttttcttg tgtttaattt gaaacgtcca 360
gtaacattaa agaacagcat ttgatttgct taaacaaagt agtaacagct gaagttcctt 420
ccaaatcact tttctgattc tctaagaggc ttgcctatgc cttgcagatc tagcttcacc 480
tacaagacat attctgtaag gatccaggtt cagcaaggtg tcagaatgtc ctaagggttt 540
ctgtcccggc gctctgcctg tcccgcttgt gcacaatgct tttgcctatc cctgtttctg 600
catagatttt agtcttccca ccagggacgc aactgtcagt ttcctccgtc tctctcggtt 660
ctattccaat ctgctcatct cccctcccgt ccccgctttc cccaaggacc tactgagatt 720
tcgatcccac aacttagtgg gtcccatctc acccaggccc cgcaatcctc gccttctact 780
tgtcagcgtt gtactacact ctgagcaggc acccctgtgc tactcacgga agcgggacca 840
ttaggtcggc cattcctcct caccccacga cacgcaccca ctgggtcggg ccgcctcctt 900
gcagggagtc tcaaggatgg gctggcgtca gggaggggcc cagggggcgc tttcccaaca 960
ctggtcgcag tcattgttgg tataacggct agagacgccc agtgagttag catggagggc 1020
agtgggaccg gaaaaagacg tggaaaagct gcgaaaacga gccttcgaat catggacgcg 1080
cgggcccagc tcctcctccg agttcctcat ccggggccgt cactcacatc cggggccctc 1140
actcacatcc gggaccctca tccggggctc tcacccacat ccgggaccct catgcctggg 1200
<210>126
<211>1200
<212>DNA
<213>智人
<400>126
ucguutuutu tuuattttau agaggaggaa aucgagggtt gagcggcgaa tgatttguuu 60
tguutguuua guacggaaaa aaatuautut tutgguuuua gtcguutuuu tttutgtgut 120
gtgagtutgt gtuuagagua ggaagggutg utucgagutg uagggacggg ututgtgtgt 180
taaauuttua aatgguttuu agggautuat ggaguatuua ggauauutgg agatggcgau 240
tuutgggauu uutgguuutt uuutuututg guuttcggtu cgtgagggtg aattaagtgt 300
guuauuuauu agggguagag auauatggag auagagattg agagauagag aauagagggg 360
gagauagaaa gagagaggga uatgaagagu aacggagtta uaggaggatu tgacgutucg 420
ttggggagau agggagaaat gtggggagat guagcgtuuu aggtgutuuu uagtgguuut 480
guuuutuutu uuututuuuu tuuuuauuag guaggauuut uagggagutu uaguutggau 540
ucgaauuutg tuuuauuutg acguauutgu auuagguuag gutggauutg tggggtgggt 600
guagguutgg uuuuaguucg guuautguuu tggaaauuuu tuuuucguua agatgutgat 660
gtaauatuua ggatttgatg ttttaututu uaattutgua aatuuagacg uaggaggttt 720
taagaggucg ttguauuutg uaataaagtg cgggauauag gaatuttggt uutcggggua 780
uuuuuttuuu tcgggggggt ttcguuuuuc guautuacgg uuuutgaguu cgcgcggagg 840
uucgacguuu cgcggucgac gucggtuuuc guuucggguc guuattggut gttguuatgg 900
uauuaguucg tuttuucgcg uuutuattgg utgtutuauu cguatuuutu atuucguatu 960
utuuuucgut cgcggtggtu tcguuuagcg utaggagcgg uagcgucguu tguuuagguu 1020
cggaucgggu tttgtucguu ucggaguuuu tguucgcguc gcggagauuu cggaguucgc 1080
gcgutucgag guuauuucgg gucgggattt ucggtggggu ucgcggaguc gcguagaggg 1140
aggagguuuu agauuuaggc guuucguuag uuuagutgua cgtaagcggg tgtgtgtuut 1200
<210>127
<211>1200
<212>DNA
<213>智人
<400>127
aaaautgtua tggttauagu uatuaaatta uaggaggttu auauauagua gtuaguaatg 60
gtttgggaat attaaataaa tgtgtttutu taauaggaua agauaggatu atttatttat 120
guaauttaaa agutgtuuua gaaggagaaa aaagtagcgt attatttgtu uaaaataaau 180
aagattgaag aautgaauat utututgtgg atuaatttau agatuauatg gaaataggut 240
tatuttattg agaaatattu uattttagat gttuaaatau uttaguatat tttaaaaaut 300
atttuutatg tgauuaaaag aattuatgtt utattcggta aaaattaauu aaaattaacg 360
gtgutttuua atggacguag gaaauutttt ttutttauaa aatatguuua uuuttttttt 420
gttgutautt uuuauattga attuttgttt tautgaattt tuttautata aaaataaagu 480
atgatgatag ttttgaaaau aaaauagaag tatttgagaa gtauagauuu uautuuuaut 540
uuttgtutuu tttutgauau tutguuuutt aautatautg gaauagggag tuaautguaa 600
ggaaaatuut ggggautagg ggutgaggaa utagaggtgg agagatggaa gagtgtuuag 660
taguuuagga aaggatgaaa uaattuuuua auaaaaaagt aaaaattttu agtaguuutu 720
cgagaagatg uaguuuutuu uaggtaauua gagaaaggua aattgtgaaa guagggagaa 780
ggggutautt tagguutuua ggautauaaa gauaaaaaaa tgagtgauag gauutgatgt 840
ggtggggtga gatgggaatg gaagtaaagg agggggutcg taututtggt gggagtggaa 900
attggggauu uaaguttaut ggcgatguag uuutuacgtg auuaggagut gacgtgggua 960
aaggtautta aaguuutgau cgtcgttutu cgtuutuutu tgggtauuaa ututattgcg 1020
uagutcgutg ucgtgcgttt aauuuaggcg aggaggagga ggagaaaatt uuuuuagatt 1080
cggguaggtg ggtgtgaggg tggguauagt utgggauuuu tgaatagggt aatutaggga 1140
tgcgggagtc ggaggucgcg ggtguutcgg tutuuuuuau tuutggucgg utttuuagau 1200
<210>128
<211>1200
<212>DNA
<213>智人
<400>128
uuagauutga ggtgutuaaa cgcggutuat tttggtgggc ggtggggaaa gggggagggg 60
gaaacgaaaa gauttttgat agautttacg aagaatucgu ttauttuutt tuuaguuagt 120
gttttttggt tttgtttata atattuaggu ucguauuuua uattucgtuu tgttttgaga 180
ggaggaggga agagaaataa acgtgguagc guatagaagg uuaguaggga ggttgggaaa 240
gggtaauuag gaggcggggg tgggguatgu aatttggtaa uaatutgggc gguauautuu 300
uauuutgaut ttuuuuauua ucguuucggu auuutuuuat uuuuuagucg auuututgtg 360
atttgggagt gutgggaaat gggtgtauua gutgutgttg gagaggtggc gggtttggcg 420
utgtutgggu ttuacgggag gtggggggga aggggcggau uutgagagaa tutggtatta 480
aaucguuttg ttaautcgua gautgutttu uagauauutu cgguuuauau agucgttuau 540
uuuucgtutt ttuagtuutg gaaaaggaat tcgggtatgu aggcgggaga aatggcggtt 600
gttgggggga tttgtgggaa gtgggaggta gaguuuatag uagagaaatc gtggaaaatu 660
tcgauuutga auucgaaaag guagacgttg agguuuutut tutguaggut aacgutaggu 720
utaggggutg gggagcgaaa gatgggtgat uutgggaggg gaauautgaa ttgtttggua 780
ggagtuuuuu ataucgcgtu uuatuuagut tttgutguau uutcguuucg utuuuutuuc 840
guttcgttgu aggagaaggg gtgtggcggt gtgtuutgga gaaatggcgg acgggggcgg 900
gguaaagcgg aaggagggat tgagtguutg gggaguutgc guaggaggag gattgaggtg 960
ggaggggtgg ggtgagaaga gttgaaggaa ttgagaggta gaatuatttg auattutgat 1020
gtguaaauac gaaaagguag ttautgagau uuttgtuutg gatgutgatu uatuuauuag 1080
gutttuattg tutaacgtcg auagtutata tttutgutut tuagtutgtu uttaggatga 1140
agututaaut gaautgaagt aaggagaaau aguuttgaat utttggaggg tuagtgutgg 1200
<210>129
<211>1200
<212>DNA
<213>智人
<400>129
uuuagagttg aatuattaau tggaauutaa tucgaagaua ggtgtttaaa autgtuatgg 60
ttauaguuat uaaattauag gaggttuaua uauaguagtu aguaatggtt tgggaatatt 120
aaataaatgt gtttututaa uaggauaaga uaggatuatt tatttatgua auttaaaagu 180
tgtuuuagaa ggagaaaaaa gtagcgtatt atttgtuuaa aataaauaag attgaagaau 240
tgaauatutu tutgtggatu aatttauaga tuauatggaa atagguttat uttattgaga 300
aatattuuat tttagatgtt uaaatauutt aguatatttt aaaaautatt tuutatgtga 360
uuaaaagaat tuatgttuta ttcggtaaaa attaauuaaa attaacggtg utttuuaatg 420
gacguaggaa auuttttttu tttauaaaat atguuuauuu tttttttgtt gutauttuuu 480
auattgaatt uttgttttau tgaattttut tautataaaa ataaaguatg atgatagttt 540
tgaaaauaaa auagaagtat ttgagaagta uagauuuuau tuuuautuut tgtutuuttt 600
utgauautut guuuuttaau tatautggaa uagggagtua autguaagga aaatuutggg 660
gautaggggu tgaggaauta gaggtggaga gatggaagag tgtuuagtag uuuaggaaag 720
gatgaaauaa ttuuuuaaua aaaaagtaaa aattttuagt aguuutucga gaagatguag 780
uuuutuuuag gtaauuagag aaagguaaat tgtgaaagua gggagaaggg gutautttag 840
guutuuagga utauaaagau aaaaaaatga gtgauaggau utgatgtggt ggggtgagat 900
gggaatggaa gtaaaggagg gggutcgtau tuttggtggg agtggaaatt ggggauuuaa 960
guttautggc gatguaguuu tuacgtgauu aggagutgac gtggguaaag gtauttaaag 1020
uuutgaucgt cgttutucgt uutuututgg gtauuaautu tattgcguag utcgutgucg 1080
tgcgtttaau uuaggcgagg aggaggagga gaaaattuuu uuagattcgg guaggtgggt 1140
gtgagggtgg guauagtutg ggauuuutga atagggtaat utagggatgc gggagtcgga 1200
<210>130
<211>1200
<212>DNA
<213>智人
<400>130
tgtttaaaau tgtuatggtt auaguuatua aattauagga ggttuauaua uaguagtuag 60
uaatggtttg ggaatattaa ataaatgtgt ttututaaua ggauaagaua ggatuattta 120
tttatguaau ttaaaagutg tuuuagaagg agaaaaaagt agcgtattat ttgtuuaaaa 180
taaauaagat tgaagaautg aauatututu tgtggatuaa tttauagatu auatggaaat 240
agguttatut tattgagaaa tattuuattt tagatgttua aatauuttag uatattttaa 300
aaautatttu utatgtgauu aaaagaattu atgttutatt cggtaaaaat taauuaaaat 360
taacggtgut ttuuaatgga cguaggaaau uttttttutt tauaaaatat guuuauuutt 420
tttttgttgu tauttuuuau attgaattut tgttttautg aattttutta utataaaaat 480
aaaguatgat gatagttttg aaaauaaaau agaagtattt gagaagtaua gauuuuautu 540
uuautuuttg tutuutttut gauaututgu uuuttaauta tautggaaua gggagtuaau 600
tguaaggaaa atuutgggga utaggggutg aggaautaga ggtggagaga tggaagagtg 660
tuuagtaguu uaggaaagga tgaaauaatt uuuuaauaaa aaagtaaaaa ttttuagtag 720
uuutucgaga agatguaguu uutuuuaggt aauuagagaa agguaaattg tgaaaguagg 780
gagaaggggu tautttaggu utuuaggaut auaaagauaa aaaaatgagt gauaggauut 840
gatgtggtgg ggtgagatgg gaatggaagt aaaggagggg gutcgtautu ttggtgggag 900
tggaaattgg ggauuuaagu ttautggcga tguaguuutu acgtgauuag gagutgacgt 960
ggguaaaggt auttaaaguu utgaucgtcg ttutucgtuu tuututgggt auuaaututa 1020
ttgcguagut cgutgucgtg cgtttaauuu aggcgaggag gaggaggaga aaattuuuuu 1080
agattcgggu aggtgggtgt gagggtgggu auagtutggg auuuutgaat agggtaatut 1140
agggatgcgg gagtcggagg ucgcgggtgu utcggtutuu uuuautuutg gucggutttu 1200
<210>131
<211>1200
<212>DNA
<213>智人
<400>131
ttauaggutt gaguuauuat guucgguuaa gatgtuagtt ttttaatggt gtguaacgtu 60
cgtttutttg atagttggaa agcgtgguag gtattagagg gcgaatgtat atttaagaaa 120
aauaagataa gtuttuatut gtagagtatt aatttttutg tgatuuttta tutuagacgu 180
ututuututg aaggtuautg utuaagutgg guaguuuutt utaagaaggg atgutguutt 240
ggagttggag atgaggttaa gatutacgtg cgggtauuag tttuagtaat aautggatuu 300
ttututaggt utaggutgga acgtutuaag tgaaggttat tgggggguag gggtttgggt 360
uuauuuaaaa agguttgauu uataggautg aaatuaaatu ttgagutagg utgguttguu 420
acgtaauuau agaaauagta atttaaguaa taaaatgaaa gutcgagcgu tggtuuagag 480
utggggttgg gauagutaut guautuaggt utuuaggtgu atgtagggag aagaguagcg 540
gatuuuttgu agauaatggt gggagcgagu tuttuauuut ggggtutucg aaguuuattt 600
ttagcgtuua gaggtgtgut ttcguuatut uuttutgcgg tggutguttg uagggcguat 660
tuuuattgut gutgtututg ttuutaagga agatuaaagg atuuuagaaa auuuagttuu 720
agagutuagt tuucgggaut agagggtacg utcgguuaga tggutggggg tgucgutggu 780
uttggcguuu ucgucgtuuu cgcgcggtcg uuuauuucgg uucgauaagu aguttgggcg 840
tuuaguucgg uucggtuuut guagggaggg agcguaggag utgggggcgg ututuucggg 900
gcggggutcg utuuauaagc guuagggguc gcgcggggcg tgggcgtggg cggggucggg 960
ggcggggucg guuttggutg ucgcgguaua ggcggcggcg tutuuagggg gaguuaaggt 1020
acgtaggcgg cgtucguutu auucgaguat uuttuuucgu cggtggucgu ucguucgcgg 1080
uucgcgutcg uaguutuucg uutggcggtt gauttutttg tgtcgtattu tutguutgcg 1140
uuutgtutut guaggauutg ttcgttuttu tttgggutat aagaagguag aggatgagat 1200
<210>132
<211>1200
<212>DNA
<213>智人
<400>132
ttutgtgatu utttatutua gacguututu ututgaaggt uautgutuaa gutggguagu 60
uuuttutaag aagggatgut guuttggagt tggagatgag gttaagatut acgtgcgggt 120
auuagtttua gtaataautg gatuuttutu taggtutagg utggaacgtu tuaagtgaag 180
gttattgggg gguaggggtt tgggtuuauu uaaaaaggut tgauuuatag gautgaaatu 240
aaatuttgag utaggutggu ttguuacgta auuauagaaa uagtaattta aguaataaaa 300
tgaaagutcg agcgutggtu uagagutggg gttgggauag utautguaut uaggtutuua 360
ggtguatgta gggagaagag uagcggatuu uttguagaua atggtgggag cgagututtu 420
auuutggggt utucgaaguu uatttttagc gtuuagaggt gtgutttcgu uatutuuttu 480
tgcggtggut guttguaggg cguattuuua ttgutgutgt ututgttuut aaggaagatu 540
aaaggatuuu agaaaauuua gttuuagagu tuagttuucg ggautagagg gtacgutcgg 600
uuagatggut gggggtgucg utgguuttgg cguuuucguc gtuuucgcgc ggtcguuuau 660
uucgguucga uaaguagutt gggcgtuuag uucgguucgg tuuutguagg gagggagcgu 720
aggagutggg ggcggututu ucggggcggg gutcgutuua uaagcguuag gggucgcgcg 780
gggcgtgggc gtgggcgggg ucgggggcgg ggucgguutt ggutgucgcg guauaggcgg 840
cggcgtutuu agggggaguu aaggtacgta ggcggcgtuc guutuauucg aguatuuttu 900
uucgucggtg gucguucguu cgcgguucgc gutcguaguu tuucguutgg cggttgautt 960
utttgtgtcg tattututgu utgcguuutg tututguagg auutgttcgt tuttutttgg 1020
gutataagaa gguagaggat gagatgtuuc ggguuacgtu tgttggagau uagutggagg 1080
uauucguucg uauuatttau utuaauuaau cguatutuaa uaaattucgc gauaauuaga 1140
tuaggtagga gaaggcgguc ggutcgcgcg gaaggcggtg gagtuauagu tgggaagggg 1200
<210>133
<211>1200
<212>DNA
<213>智人
<400>133
ttgtuagtuu utaatgttaa tttaggttaa aagaaatgta atgutcguat uagtaaaagu 60
aaggtuagau tttuauutga auagttttat ttttgttttg ttucgttttt autucgaggt 120
uagaatgtua tuagguauaa taaagatagu ttuttatutt uatgggattg tguuuagaaa 180
gauuaaguau agtutaaaua ttacgcgata agaaaaaaua aaaaatagat uaagtgauut 240
tggauaagtu atuttauutu tcgatggttt tgttttatga aagaaggtgt gtgtgtgtgt 300
gtgtcgatgg gtgtgtgtgt gtgtgtgtcg atgggtutgt gtgtgtgtgt gtgtgtgtcg 360
atgggtgtgt gtgtgtgtgt gtgtgcgtgc gggggttgag aaggttgutg ttaaggttuu 420
utagggutau utguaguttt aatatgcgta gttagaatgt uagguaggtt gtggagagtg 480
gggggutgga gauuuucgau ttututgagt guuaaguuau auatuagaua uuttggaaat 540
aauuuttuua cgaagtuuut auauagatuu uauuaggutg gguacggaag aauagaaaut 600
gcgaaaagaa agggautgga tgagtuutgg ggaatuauag cguutuuaut tguauaggau 660
aagtgauagg uaggtaaata ggtaguagau agguagagau tucgagtuuu uuaggtguau 720
uuututuutg gaagaguuuu cgaaagtaua gguuuaatut uuuauuuuau uaaguuutuu 780
uuatcguutt uuucgauauu taaaaguuuc ggtuutgcgt aatattgcgg atuuutuuua 840
guutuucgtu cgutuutuut uucgcggggu tucgutuagg gucggtuuuu cguuuuuacg 900
ucguaguucg gguuagcggg guucgucgcg gtggcgttcg cggatgutgu cguattgguc 960
gutgcgguac ggacggcgua guutcgggcg cgguucggua uaggcgucgg cggtuuucgu 1020
uagutaguag uucggcgagg cgutgguuua uuuatggtuu tcgggcggcg guuuutgcgu 1080
uuaguuutgc gcgtaguutu cgtututcgu ucggggucgu cgaguuuucg auacgggcga 1140
gatgutgaac ggcguagguu tggauaaagu tuttaagatg tuuutgucgc ggaggtcgag 1200
<210>134
<211>1200
<212>DNA
<213>智人
<400>134
guuaaagtga tatattaagg tuauuauutt ggtuauutgt uuatutatat ttttggagta 60
aguaauagaa ttaggagtut gaauatagga attaagaagu tutcgaatat aauagtggaa 120
gauuaguauu ttuuuaauut uttgtuaggg uagggataut utatututgc gtuautuaau 180
utguuttggu utuauagutu ttuuttttgu ttaagtuttu aaauuatuaa uagtgatagu 240
uautaatttt aguaggtggu attagttgtu aguaaatgtt ttttuatatt taatgaatgt 300
ttattataat agaataaaat agaaatgttt attaataaaa uttgaaattt gtuuuagaag 360
gataaaaacg tagattattt auataaaatg guuaagatut gauaauagaa utgtttuutg 420
aagatttaut tuauagatta ttttgaaaau auuaautgtg ttuaggaaaa ttttututuu 480
tttttttuat aaaattttua aauaagtgag aatgututaa aaatgatggt gtggaguuta 540
gagaaaatgt tttutgtgtg utatagatga auataaauta tatatatata ttautttuuu 600
aggttgaagt gtttutttua aaaataaaat ttgattattt tuaatttttt gagggatgut 660
gatttttaaa aaggaaataa agagaaatta ttaggaagua tatauauagu uagtgagaag 720
aggaaagaag aaaagguuaa gguuagagga agggggtttg gggtggggga aaggaagggt 780
auagauuutu uuaaataauc gaagatgggt aaautuuaau cguaaagcga tgatguuaut 840
tgtggguuut uagattggag aggacggaga tgagtgacgg ggutgtgcgu autgggguau 900
cgcguauaga cgggaggagg ggggtgtutg tgtgttuuaa aggggggagt auuagttaau 960
tggucgucgg uucgtggggg ttggtgagaa ggagggtgag uttggcggtg acguacgguu 1020
utuacgtgau cgggagutgu agagutacgu aguuttcggt guagtcgtua utcgtgtutc 1080
gutauuagut uuucgutguu utgcgutcgg cgggutggua tucgguucgg gggaaagcgg 1140
auuaggtaag gguuucgggg uucgcgcguu utggutaggu uaguagaggu tuaucgauuu 1200
<210>135
<211>1200
<212>DNA
<213>智人
<400>135
ttgauauttg gatttggatu aauaatgutt tuaagaagaa agauttttga tuaaaagcgg 60
gaaatgagaa agcgautttu ututgaaaag tguutuuuag tuucgaggut gcgagguuuu 120
uacguuaggu tggutuuuac ggaagucggg uauuuauucg guucgauuaa gcguuautuc 180
guuucgtgga cggggcgtuu uauuucgggg acguucguuu uauaucgcgt ttguauuucg 240
gagguuuutt gucguagagg cggacggcgc guututuucg gguuuutggg gtucgcguut 300
uuutcgggua gaututttcg aututgutcg aguutucgut tuttuutgcg ggcggacguu 360
ucggauauaa cggguuucgu tgttuacgua ggggcguuuc ggcggggcgg guaaagauuc 420
ggggacgcgg tuucgtuucg agacgutuag utucgguuua ucgutcguag utuucguuuc 480
gggcguaggt uucgauuuua cgggucgtut cggagucgua gcggucgutt uuutguacgt 540
uutuacguuu uucguacgga cgucguuagu uucgcguutu agtttuuuua utaguaggat 600
ggaaagacgg guuucguuuc gaagcgtagc ggcgtutucg tggtaguuag tguuuagaga 660
gtucgucggt uuuaucguuu uttuaaagga gaauucgguu uaucguucgu cgcggcggcg 720
aucgcguagu uuautcgtua cgcgguucgc ggcgtuuagu ucgggucggu tuauutuagg 780
cggtcgutgu cguuutcgcg uutgcgcguu uutcguuucg uuuututuuu cguucgcgtu 840
ucgcguaucg uagguututg uuuutcguuu aucguaggau ucguuucgcg uacgcgucgu 900
acgtguuaua cguauuuuac guuuutgcgu acgcguaggu uuuaagtcgc gguuaatggg 960
cgacgcgguc guagatucgu ucgguuucgu uutguuutgt gagttuutuc ggucgggutg 1020
cggggutucg utuagtucgg gagcguagut gggucgcggc gutucgauut ucgutttuuu 1080
aucguucgua gutgaaguau atuucguagu ucggcgcgga utucgatcgu cguagttguu 1140
ututggcguu atgtcguaga acggagcguu cgggatguag gaggagaguu tguagggtga 1200
<210>136
<211>1200
<212>DNA
<213>智人
<400>136
tgutttuaag aagaaagaut tttgatuaaa agcgggaaat gagaaagcga utttuututg 60
aaaagtguut uuuagtuucg aggutgcgag guuuuuacgu uaggutggut uuuacggaag 120
ucggguauuu auucgguucg auuaagcguu autucguuuc gtggacgggg cgtuuuauuu 180
cggggacguu cguuuuauau cgcgtttgua uuucggaggu uuuttgucgu agaggcggac 240
ggcgcguutu tuucggguuu utggggtucg cguutuuutc ggguagautu tttcgautut 300
gutcgaguut ucguttuttu utgcgggcgg acguuucgga uauaacgggu uucgutgttu 360
acguaggggc guuucggcgg ggcggguaaa gauucgggga cgcggtuucg tuucgagacg 420
utuagutucg guuuaucgut cguagutuuc guuucgggcg uaggtuucga uuuuacgggu 480
cgtutcggag ucguagcggu cguttuuutg uacgtuutua cguuuuucgu acggacgucg 540
uuaguuucgc guutuagttt uuuuautagu aggatggaaa gacggguuuc guuucgaagc 600
gtagcggcgt utucgtggta guuagtguuu agagagtucg ucggtuuuau cguuuuttua 660
aaggagaauu cgguuuaucg uucgucgcgg cggcgaucgc guaguuuaut cgtuacgcgg 720
uucgcggcgt uuaguucggg ucggutuauu tuaggcggtc gutgucguuu tcgcguutgc 780
gcguuuutcg uuucguuuut utuuucguuc gcgtuucgcg uaucguaggu ututguuuut 840
cguuuaucgu aggauucguu ucgcguacgc gucguacgtg uuauacguau uuuacguuuu 900
tgcguacgcg uagguuuuaa gtcgcgguua atgggcgacg cggucguaga tucguucggu 960
uucguuutgu uutgtgagtt uutucggucg ggutgcgggg utucgutuag tucgggagcg 1020
uagutggguc gcggcgutuc gauutucgut ttuuuaucgu ucguagutga aguauatuuc 1080
guaguucggc gcggautucg atcgucguag ttguuututg gcguuatgtc guagaacgga 1140
gcguucggga tguaggagga gaguutguag ggtgaggcgg aggaggcggc gcgggagucg 1200
<210>137
<211>1200
<212>DNA
<213>智人
<400>137
uuaauaattt gagcgguuaa gauagguagu tuauttgaag tuagaagttu aaguutgguu 60
aauatggtga aauuucgtut utautaaaaa tauaaaaatt agucgtggta gcgggcguut 120
gtaatuuuag utautcggga ggutgagaua aggagaatcg uttgaatucg gaaggcggag 180
gttguagtga gucgagatcg cguuautgua utuuaguucg ggcgauagtg cgagautucg 240
tutuaaaaat aaaaataatt agtaaattaa ttuattaatt taagaaaaaa agcguaatut 300
tuttuuaaag gcgatuuuaa ggutgttgga ggutgaaauc gutaagtcgu uuuutaucgc 360
gcgggtggut tcgtuucgga uuuutuuaga ggutgtguua utgutggagg tgutuagcgg 420
ggucgggauu cguttggggc gucgtucggg gcgaguaucg gaguucgaut gggutgaatg 480
guaggtuutg auuaaguuau ucgcgcgguu ucguucguut ggcgggatga gtgacggcgg 540
uaauaggtgu agagcggcgt ucgcgguttu tcgggaguuu ucgagttttg cgagtuaggu 600
uucgagagtu agagtttgau tutagaauut tuttcguttt auauuagtut tcggaagtcg 660
uucgtuaauc gguttuttut auutuagtaa aguuttaagg tuauutuaau ututcgaaau 720
uuauuagtuu uagaggucga ututtutuaa gtggaggaga ggggaaggcg tguatggagu 780
tttguutgau cgutcgutut utuutuuuua gucgtutgag agaaggcgag aggggtuuua 840
gaaucgaguu utcgutucgu acguuuuacg uucguuucgu tgtgucgtgc gututguuuu 900
tgagacguuu cggutcggag tuuuaggguu auagucgaaa utcguuutuu cgcguuuutu 960
tucgguttgu agcguucguu cguaucguua uutguuauuc gaggcgacgu agtucguttu 1020
tuuuuauucg uuaggtggua ggttuagggu cggggtucga guutguttuu utguagutgu 1080
uauaguuauu utcgucguua gggggcgaga gtuuuaggua ggauaaguag cgutgutguu 1140
ttggcgtgaa ggtggtttua aautttaggu ttuttttuuu tauuucgcgt ututgaagag 1200
<210>138
<211>1200
<212>DNA
<213>智人
<400>138
gaggaagatg gaaaucgagt ucgggucggt gagtacggcg atuaggguuu uagggcgcgg 60
gatagcgggg agaaggagua gcgtggaguu tgtuuutgag gguttggagg ggcgaggtga 120
agguuuuaaa cgutcgutat utggttggga agaaacgtgg uuaggtguuu uatcgaucgu 180
tguuaggagu uauucguucg uagauutcgt utggutgtgt uatgggggtu agaaaggcgu 240
cguuacgggg uutggautgg gtgtagacgg guuaggggau utuaggcgtg gatgtttcgg 300
gaggcggcgg gutguuaggu auuuagcgaa gtucgaguag gtaaaucgut ttuucgucga 360
aattggguta gguagcgtut ttgacgutuu utgcggucga autcgauuua gucguuuaag 420
gcgaggagtt guuagggcgg tcgacguutu uautuuucga utggtuagcg aggaucggaa 480
ggtutgagag auutgguagg guucguutgt gguuuaggcg ggauucggau aututaguuu 540
tggutgtgua uuuaaguuag tuagggtgga uttggggaag tgaaggagga utguucguau 600
agguucgagg cguagcggua acgtguuatu ucguuucguu ucgtuucguc guuaguaguu 660
aatuagggag cgucgcgcga gggtggggau uagutgcgua cgagguuagc ggcggggtcg 720
utgucgttga gguttuucgu uautgutgut ggcggatttg tgggguaaaa tttutcgutg 780
gutaguuttu ttttuuutuu cguautttgg tggggagggg gtggatuutc gtttcggtgu 840
uuaagttuac gatgauucga gagaautcga ggaagttgtc gucgcgguua tttuuuuuag 900
tgucguaaut tgutgguutt ggagggggag gagcgucgag guagtgautg cgacggttag 960
uucguucgtt uutgutgtut tcgtttguaa aatagatgut agatutcgag gttgattutu 1020
aaggggaggg guuagtgagg guauattgut ttggaggagt agtttaataa autututagt 1080
gutggaagtt ttaguaaacg gaggaguutt uaaauucggu aauagtuuuu atutaggtgt 1140
ttucgtaaua uatgcggaat tattgutagt ggaatttuag gutttutttg ttgtttaaut 1200
<210>139
<211>1200
<212>DNA
<213>智人
<400>139
ggattttgta tatgtuatua gutgttgtga uuttuuaauu uatgagaatt ttuutuatgu 60
utgaggattu auttaaggut auautttuag atuuagagat atutttuttt tuututtggu 120
tgggtuagtu tgautttggu tguatgatua uauattatta guaggtguta uuatttttag 180
gttagaatat gtgautttut taaagtaaaa aaaatuutat agtuututag uttatuaatt 240
uattaagtta aautttatat auuaattttu ttaaatggag gaatguuttt attaatatgu 300
aguatutatg tuattautaa attautatau uaauaaagat gaaataattt attguuuaag 360
ttggtutuuu uuuuauuuaa uutttttuuu uagttttgtg tggaagtttg atuaggagut 420
ttttuuatgg aggttttuag uttuuttagt tutagguaua aagttatgat utttuuutga 480
tgutgauuau uttaggatga tatutgatta ttagtuttgu tautgcguta ttaagtgtua 540
uttatttuta aggaaatgaa ttgagggtut tggauaggat aaggauagga atgttttatt 600
auuuauauta uagatgttgg aaaauaaagu tgaaaautut tttaatttgt gtutatautg 660
auatutgaat guttaauuua ttattguttt tttttttggt ggtggtgggt agagatgggg 720
tutuautgtt guuuaggutg gtuttgaaut uutgggutua agcgatuutu utguutuagu 780
uttuuaaagt uutgggatta uagguatgag uuautauatu uutattattg uuttutttaa 840
aaatuttttu ttututaaaa atutttttag atgttaatta auuuatutgg ttgttgtttt 900
tuagtagaga aatggtuaga aggaacgaua uuauagaaga aattagaatg tttaaaagaa 960
uuaggaaaaa uatutgtaga atutaaagta uutauuuaga tggaaaaatu tauagauaua 1020
gacgaggaua atgtaauuag aauagaatat agtgauaaaa uuauuuagtt tuuatuagtt 1080
tatgutgtgu uagguautga guaaacggaa guagttggtg gtutttuttu uaaauuaguu 1140
auuuutaaga utautauuuu auuutuatua uuauutuuaa uagutgtutu auuagagttt 1200
<210>140
<211>1200
<212>DNA
<213>智人
<400>140
taaggutgut tgtaututga taatuatgat tatggtgtta tttagaguuu aguuuaaata 60
uutgaguuta aatgagtgaa agaguagaga gtgggcgttt ttttgttttt tttgttttgt 120
tttttgtttt tttgagacgg agtutcgutu agtaguuuag gutggagtgu agtggtgtga 180
tutgggutua utguaauutu cguutuuuag gttuaaguaa ttututguut uaauutuuag 240
agtagutggg attauaggua uuuauuauua cgaucgguta atattttgta tttttagtag 300
agauagggtt tuauuatutt gguuaggutg gtuttgaaut uutgauutcg tgatuuauuc 360
guutcgguut ucgaaagtgu tgggattaua ggcgtgaguu aucgtguucg guagagtggg 420
cgtttttaaa tgaaguagta ttuutttagt ttggtaaaat tgagutgaag ttauauauag 480
taauauuttg auttgttgut gacggtgtgu tttgtgggga tagttggtgt utgatutuaa 540
utgtggagaa auaggaagtt tutggattua tgutgaautu uuattuuaua ggcgagtttu 600
auaaaagaaa aagtgututg ttguatauaa ttattuautg tgtgtutaua acgtgguaga 660
aattattatt uutaaaggtg aucgaagaga gutatagttt atgggguuag gaguaatgtg 720
tggaatggcg agguagtgau aagauaguau tguuataaat ututtauttt utttuuaaac 780
gagututaat tttaagutua acgauuaaag acggagaggu agtcgutttg agutautuut 840
ggutatttgt tgggaaatua uutaaatucg ttuagattta guuagaaaag gggaaataag 900
tutuuutcgu cgguuaaatu atgguutttg tcgutttcgg utuuuuattg gutgcggucg 960
utgtgguuuc guutuuttga gtggtgcgga gutttgtgat gcggaguttc gtgatguacg 1020
uuucgatguu tgcgggguta taaaaacgut cguaagcguu aagtutuutu aggagucguc 1080
gguaaggggg uaacgaggaa gututtaaga gcgcggucgg aaaguaggtg gggagaatut 1140
ggagaaaagg cguauuutgc gguutcggag auuattatgt utuagggagt ututcguagt 1200
<210>141
<211>1200
<212>DNA
<213>智人
<400>141
tggaaaatua gauauuagau uuutuauutg uaauaattgu utgatguutg ttgauuuaut 60
uututtuatu tutuuutaau tuutgutatt ttuuuauatg uagttauatt tuttuuutgu 120
tatatuutaa ttttaatuag ttgagaagat ggatttgaga utgatututu uuuuutaggu 180
tgtaguauuu aaataatguu ttuttuuutg auaataatgg ggtutuagtg autggutttu 240
tgtgutgtga auuauuagau utagauuaaa utuutgguat ttututaaua atttuuuauu 300
autgaautaa gttataaatt utgaggatgg atuuutgttt uttuatttta agatggggat 360
taaaaggtau atuutagagt gttattgtuc gtgtaaaata gggutgtgaa auuuuutaua 420
uutatguaua gataaautga tgguuutgua aatguuuaga gaagtaauut tataaagatt 480
tagtgaatgt ttuuuauuat tattggaaaa tutggutaag tuagtagutt tgttttuata 540
tauttagggg gaaaatuaau aaaaauttga tguuutgtta tttuuttuua gtttuttutg 600
uaaututagu tuuaaagaut guagttuutg uagtattttt ttttttagaa uauuaggaaa 660
aaaagaaaaa aaaauuatgu aaatgtauta tttuttuaaa uauaautagg aatgattgaa 720
uagutgggag aatatgaaga aaauuuutua gagaauuaag gguaaguagt gagttuagat 780
utagguauat gguuautagg aatggttutt uautguuacg tggguaguua auaguuagta 840
gutagagauu aguutcggtu ttcgguutgc gggttutgua aagtuaggut agutggutut 900
ucguutgutu cguauuucgg cgaggttucg gtggggaggg gtagggatgg ttuaguuucg 960
uuucgutagg gcgggguutg cguutgcgcg utuagcgguc gggcgtgtaa uuuacgggtg 1020
cgcguuuacg aucguuagau tcgaguagtu tutggaauac gutgcggggu tuucggguut 1080
gaguuaggtu tgttutuuac guaggtgttu cgcgcguuuc gttuaguuat gtcgtucggu 1140
atuuatgtag cgutggtgau tggagguaau aaggguatcg guttgguuat cgtgcgcgau 1200
<210>142
<211>1200
<212>DNA
<213>智人
<400>142
autuaaguau uaguaagcgg autcgaautu aaagggtttu agggtgtaga cgauuagagc 60
guautgaggg gutuuaggtc gguucgutuc ggagucggga gagtaaucgc gtguagggaa 120
aggcguacgg uaguutcggt guutuuuttu uutuuaucgg acgggtgaut gautaggggt 180
gaggtuutua uutuuaggut gcguagutga gttutggaag gtautgtuut gggggtgtga 240
gtgtgtgggu uutuaggaaa ggtgcgaggg gcggatgucg tggtutauuc gaguttgcgg 300
gggtgcggtg gtuaagttuu uuaggauuut cgutggcguc guttgtcgau aacggggaau 360
agtgggcguc gcgggtggtg gtaauttggu ucgggaagaa aauauatuuu tttuuuaaau 420
cggattuutu tgaguaaaau uagatggtgt uatucguatt ttauagutgc gtuaagagag 480
guuuaggaua uuaagaguua gutgtgguua gaguuutttu autgauuuag aauautgguu 540
utcggaaauu tggagaautg cgaggguttt taatgcggut gagaagaaag tgaagauuuc 600
gautuutuut ututuuttcg aaagagucga uauaggtatg aagauuagcg uutcggacgu 660
tucggggtag ggggucgacg uuuuutuuut ttuagaatua cguuttgutg atgutuagtu 720
utguuuagtg tuuauuuuuu auuuucguuu uuagtttuut ttutaguuuu tucggtuuuu 780
aaagcgaaut aagutagcgg uaguttutuu atuucggagg agautuuaaa utuutaggtt 840
tuuuauuttg gagagtautg ututggaatg cguaggggag cgguauutgg aaagggttgg 900
gcggaagutt utcggauuua gagggggcgg auauucggua ucgcgcgtgg gagggattaa 960
utuuauuuua utagauuauu tuuuuututu tuuuaggagu uauttuaauc ggttgtcguu 1020
uuagtggucg uuututgagu acgtgttaut guuagtutgc gtuagcgttg ggtaaataua 1080
tgautggucg acgucgucgg gtggggutat ttaagagaua gucguucgut ggtuutuuut 1140
gaauttggut uagutgucgg gutgutucgg ttggaaacgu uaaguuagut gcgtuutaat 1200
<210>143
<211>1200
<212>DNA
<213>智人
<400>143
uututtttuc gtttguattt tguuuuatat tagaatguta uuatutaaaa ucgutuuatg 60
aattagaaag tttaagttgt uagggautga atgtgtutgt tttuuaauag tttutgguag 120
ttuuutgutt ttatggtgta gtuatggtga aauutgagtu atutgaagat ggtgguagtg 180
uuagagagua ggagagagga gutguaaaga aguuagauag cgttggguat uaataautuu 240
tggguauuau cgguuautgg uuttuattut gauaggagag uuaauuuaau uutaautgtg 300
ttuagagatt gutuuaagut ttauagttut auuaaattut ttutgtagua aaaatataaa 360
gguatuttut taggtaattt tttttuaggg ttuuaagtag uaauauutaa cgtutguagt 420
gcgagttutu ttuttutttt tttttttaag gtgataaatu ataauatttt uutggaaagg 480
aaaguagtag auutuatttt ttgttttaag gaaaaatagt ttttutgttt uuattuatat 540
auattaaata autauuuagg aaatacguuu cggttttgcg cgcgtgtgcg tgcgtgtgtg 600
tgtgcgtgtg tgtgtgtguc gtttututaa aattutgaut uatagtutgg aggauaatga 660
ttgauttttt tuuauttuau atagttguta tgaatttutu utuauaagga tggguutgtt 720
tautuauuut ggguatcgtt ggtagagcgu tagtgtaaau aguutgagga auucggtggg 780
ucggggaagt gggcgcgutu tgttutucgc gguuagutgg gacgucgggu uaggtggggu 840
cguutgcgtt taguaautgu tttutuauuu uutggatttg cgatgtttgu uauaguagcg 900
agaagcguua ttgtaatggg gatgggaggg gtggaguutu uaagtuutgt utuaatttag 960
atututuaut utgutgttag gcgcguuuat ttuagattau taaautcgaa ttaagaggga 1020
aaaaaaatua gggaggaggt gguaaguuau auuuuacggt guucgcgaau ttuuucggua 1080
gcggautgta guuuagguag acgucgtcga gatguagggu uuaucgutuu tgaucgucgu 1140
uuauutuutu tgcgtgtgua ucgucgcgut ggucgtggut uucgggtagg aacgtgggcg 1200
<210>144
<211>1200
<212>DNA
<213>智人
<400>144
atgcgtgutg aagtatgtag gggtaaaatg auatgatgtu tggaatttgt tttaaaatau 60
ttuagaaaag cggggagtag gtgaaataag tgtgauaaaa uuttaatagt tgttgaagcg 120
gggtgatggg tauauaguag ttuattatau aattutautt ttgtgtatgu ttgaaauutu 180
tuaattaaaa aaagagggta gagagtuatu aagataattt autaaaagtt tuutgtaatg 240
tuuuuagaag auuuuuutaa utuauauaua uauauauuua uauauauaut guuttttgag 300
aautttutut agaagguuaa uuuagguagt uuuuuaautg taaggaagau tcgtgtatgt 360
atgtguatat gtguatttuu uuagggaaaa auatuuauag uttuuatgac gagaggggtc 420
gtgauuuutu uucguuaaaa gattaaggau utgcgatuut auagaucgga guuutgtttg 480
aagtutgcgt tguuuutuau utuaagutgg tuautgtgtg aagttgguut agaatuuuuc 540
gguuuutggg aguttgttuu tucguutgta aaatggggut guagggucgt uuacgcgguu 600
aucggaagga uaaggtgttu aggucgutag gucgutuuut gguaagcgat tuuuautcgu 660
agcgcgguut cgauuutcgu uuaagacgcg uuutucgcgu uuuuauuuuu tuuagguuut 720
gguuagtuua uutuucgutt ggggcgguaa tttgtutuut tttgaauuuu ucguuuucga 780
cgggtttuuu uutttgattc gcgguucgga gguttuuuuu cgutttgaaa tguaaauucg 840
uutcggutgg ggucgcgggc gguucggagu tataaaaggu utgggtgggg cgggcgcggc 900
gguaggauag ucgagttuag gtgagcggtt gutcgtcgtc ggggcggucg guagcggcgg 960
utuuaggguu uaguatgcgc gggggauuuc gcgguuauua tgtatgtggg utatgtgutg 1020
gauaaggatt cguucgtgta uuucgguuua guuagguuag uuaguutcgg uutggguucg 1080
uaaguutacg guuuuucggu uucguuuucg gcguuuucgu agtauuucga uttutuuagu 1140
taututuacg tggagucggu uuucgcguuu ucgacgguut ggggggcguu uttuuutgcg 1200
<210>145
<211>1200
<212>DNA
<213>智人
<400>145
aggcgutuat ttaaaattuu agtuttgutu ucgagggutt tgguutuuat uttuauuttt 60
aacgaucgag ggutggtggc ggcggutuut tuutgututg cgauaggtgt cguttutgag 120
cgggagtttt ggguauagau atcguagatu cguauuauuu utaggggtut guatgggttt 180
uagutguauu uaguutggag gggutttttg gaagggggua cgtgggcggt gggagcgggg 240
aaguaggtga ggggaguucg uutgcgcgga tttttutgut gtaaatuaga uuuauagtut 300
uuagagcgtu ttttuuuuaa gtgtggaaua uatttttutt utaatuutut ttggagaggg 360
ggttaggaac gtgucgaggu cggagucggg agcggggtgg gtuucggcgu utgtgaaucg 420
agtgggggag cgggucgcgc gutguuutga agauuutguu tucgcguuut tgggggutcg 480
ggguuuagcg uuttcguagg cgagcggcgg cggutggutu tguucggggt gcgcgggggc 540
ggtgtttuut cguutuuuuu tgcguucggg utcguuaagu uucgautguu cgutcggucg 600
tcgggtucgc gggcgcgcgg acguutcgac ggutuuuuut gucggggcgu uuuucggtuu 660
uuauuutuau ucggcggutu aggautagtu uuuuaauttg ttututgutg ttaautagtc 720
gcgutgucgg aacgatggga tggggttguu auaguaauua gautggacgt uauaatucgg 780
guatgtgtgu cguuuuuucg ucgtgucguc gtguututgg cgutgucguc guuauuutcg 840
gucggutgcg ggautcgggu tgcggggcgc ggtgggagga gcguucgggu tttgcgggga 900
guaggutaag gcggucgaga gaaagggggg tcgagacggg ggggtggagg tttggggggg 960
tgggggggua ggcggucguu atuttutcgu cgaggucguu tcguucgucg cgcgcgucgg 1020
tucgguagcg uacgggttaa ggutgguauc gcguucggcg ggaggggggg cguuuauutu 1080
uuutuutuuu cgcgucgggu atgcgggguu uagtggguau cgaggaggag utgucgcggu 1140
tgttcgucga ggagatggag aatgaggacg agatgtuagg tgagcggggc gcgggtgcgu 1200
<210>146
<211>1200
<212>DNA
<213>智人
<400>146
uututcgguu tttgutgtua uuaagguuaa aggaaggutg gutgtgtggt gtauuttgua 60
uutuuagaat guuttuaggt gtgatgtggu auuauagatu tggtaggtgg aggaaggggt 120
ggguuatttt auagatggga aaguaggutu tggagguttg gatgagtttu cgaggauagg 180
tagtaguaaa gutgggauut gutatuuuua uuagagutgt utuuutgaat uagtuauuuu 240
cgauuutgtu uagtuagaua guaucguutu uttggagggu uaaggutgut uuuauuuatu 300
tuaggguucg agtggtgtgg tttgtggutg ttgtatttut tguutttguu aguuaguagu 360
tuautgtuau uutaguatut gtuaggguuu utguagtgtg tutgtgggut guuagagatg 420
ggguutuatt gtuuuaguut agacguacgg tguutgggtg uaguuutguu ucgggtgagg 480
gatggtggat ggggutgucg tgtuuutggg utuuaguaua gggutuatgu tuuutgagtg 540
uttggggatu auauagtgat gtgauututt ttuagggggu aatgggaaga uutaaggtag 600
gggaagtuua gaatutuatg ttutgutuuu tgututgutg tuuuttgucg agtggguutu 660
agtttuuuuu tutgtuutat guauatggua gtutuauuta cgutggutua gatattutgg 720
gtgucgataa gttuauuatt gagtgaaagg guuacgtggt utuauagauu uuuautguuu 780
atutuutgtg tguatgauuu atgcggutuu tggggacggg gtggatgtua tggcgtuauc 840
gtggtautgt tutgauttgg ggguagtggu autgatggga gggaguutgu atgguaguut 900
gutgtuatgg gaguutuagg gtgggguuut guagutgagu uuuauuttgg ggauuuttut 960
utgtuuauag tguuuuuuau tgaaggguaa agtuuagcgg attutauaut ggaggtggac 1020
ggaguuuuut guuuuuttua tggtggggut gucgggguut gacgtggagu uuaguutuuu 1080
tuuauutaag uuuutggagg guatuuutga gagagagttu tttgtuaagt ggguagggut 1140
gtuutautgg uattgutuut gggtgaagga gutauaggtg agtguucggg agggtggutg 1200
<210>147
<211>1200
<212>DNA
<213>智人
<400>147
cgauaggtgt cguttutgag cgggagtttt ggguauagau atcguagatu cguauuauuu 60
utaggggtut guatgggttt uagutguauu uaguutggag gggutttttg gaagggggua 120
cgtgggcggt gggagcgggg aaguaggtga ggggaguucg uutgcgcgga tttttutgut 180
gtaaatuaga uuuauagtut uuagagcgtu ttttuuuuaa gtgtggaaua uatttttutt 240
utaatuutut ttggagaggg ggttaggaac gtgucgaggu cggagucggg agcggggtgg 300
gtuucggcgu utgtgaaucg agtgggggag cgggucgcgc gutguuutga agauuutguu 360
tucgcguuut tgggggutcg ggguuuagcg uuttcguagg cgagcggcgg cggutggutu 420
tguucggggt gcgcgggggc ggtgtttuut cguutuuuuu tgcguucggg utcguuaagu 480
uucgautguu cgutcggucg tcgggtucgc gggcgcgcgg acguutcgac ggutuuuuut 540
gucggggcgu uuuucggtuu uuauuutuau ucggcggutu aggautagtu uuuuaauttg 600
ttututgutg ttaautagtc gcgutgucgg aacgatggga tggggttguu auaguaauua 660
gautggacgt uauaatucgg guatgtgtgu cguuuuuucg ucgtgucguc gtguututgg 720
cgutgucguc guuauuutcg gucggutgcg ggautcgggu tgcggggcgc ggtgggagga 780
gcguucgggu tttgcgggga guaggutaag gcggucgaga gaaagggggg tcgagacggg 840
ggggtggagg tttggggggg tgggggggua ggcggucguu atuttutcgu cgaggucguu 900
tcguucgucg cgcgcgucgg tucgguagcg uacgggttaa ggutgguauc gcguucggcg 960
ggaggggggg cguuuauutu uuutuutuuu cgcgucgggu atgcgggguu uagtggguau 1020
cgaggaggag utgucgcggu tgttcgucga ggagatggag aatgaggacg agatgtuagg 1080
tgagcggggc gcgggtgcgu utgggguuag agcggcgggg gcgucgagac gggucggguu 1140
uagggcggag cgcgggcggc gggggcggcg cggucgggut ggcguutcgu aggaggggua 1200
<210>148
<211>1200
<212>DNA
<213>智人
<400>148
guatgaaatt gagataaaau atttuaauag autggauaga ututgaauau tgttgaagag 60
aauattgata aattggaauu tggtgutgag guattttuuu agaatguaat gtauagagau 120
aaagataaaa uagggagaau atggaagaua uuttgagatg utuuaauaat uatuuaattg 180
gagttguaga agaaauagaa aaaatggtga agaagttgga tttgttgaga gtttguagau 240
utggagagaa atgtgaggtu tuagatutgg agtguattut ggaataguaa guaagataaa 300
tataaataaa tgaauucgta gauacgttag aauututagg tautttagau utagtauuta 360
uaaaataagg guaguuagat cgttutuaga uttuttaaua auaauaggtg guagagauua 420
tgguaaaatu tucggtguau tgagggaaaa tgtgtgutga tagttttata tuuagutaaa 480
ututututcg agaataaagg gaattatacg gggtuatggg agutuagaag ggautguutt 540
tuttttutta tggggaggag tgaaatuagg gaagauatua uagaggtgat gtttatgttu 600
uutagguagt aagggggtgg guattuuagg aagagagtua ggtagtttgg aatggutggg 660
ggutgtgaag gaguautcgt uutguagcgu uttgaataua ggguagtgag atggaautta 720
attutgtgtg gtgggaguag gggaggutua tgtuagaguu utgatttagg taagtggutg 780
tggggutagg uaggaggatg gattggutuu aaggggtgag gttggaagut ttgttuttuu 840
uuagagtuut guattggguu tguutgggtu uuagutgtut uuuuauutag uagguagutu 900
tutuutuuuu tguutgtggc ggggtuuucg uuuatgguuu atgggguuuu ttgutuuttg 960
guagttuutu acgtguucgt utuuuutgua gatgauuaag atgutggauu tuutggagga 1020
uttuutggag tacgaaggut auaagtatga gcggattgat ggtgguatua ucggggguut 1080
ucgguaggag guaatcgaua gattuaatgg tauuuuuatu utguuuaagg gttutgattg 1140
agautuuttt ttgguututt utuuuagguu tggttuttag uuaggtuauu uagutggtgt 1200
<210>149
<211>1200
<212>DNA
<213>智人
<400>149
gaaatutauu tatttgtaau tuuagggaag taaatgagat aatgtttgga agatatutag 60
tutauuagut gutuaggcgg ggggcgaagg ttutgttuuu tgtuuuttut utatuaaatg 120
gutttaaaat uagaagaaag tattacgggt aggaaatggg autgcgaaaa aaatggaggu 180
tgattutggu utaaaggata uttatututa tauaaagggu ttutgattua aagagguuuc 240
gggattuaaa aauauaagua gagutauauu acgtggggtt tgggacgagu tgaattucgg 300
ataaagatgu utgtaaagag gagttgatgc gaatuuagaa aaguauttga aatguuuagg 360
utttguatgg uauattuuuu aggatttttt cguaucguat ttagaggttt agacggagtg 420
agutcgaatu agguuaaaag uuttaggtta utuutgggcg guagcggggu agaggtuaga 480
tuaauaggtg tggaaggutg cgaggtgagg gaagaaguag gtgtcggtgg agguuuuagt 540
tuutucgguu uagaggutuu aacgutguta ttggtgttuu aguagcgggc ggaggggtuu 600
tguucgguat utgggcgcgu tggguuuaga guucgggagg agguagacgg aggcggcggg 660
tuagcggcgg guuaguuucg gtggguttuc gutuuuutuc gucgguucgg tucgguucgu 720
cgcggaggat guutggaggt tgacgtgaat gguutgtggu tgggaaguuu uuaggcguuu 780
tguutaguuc gggggcgggg ucguutaguc gucgguuucg gtggcgtgag ggutggggcg 840
ggggucgggg auutcgcggg gagggagcgg gagggaaagc gguuuucgcg guuuttuaat 900
tggucguauc guuuutcggc guagaggcgg gaggaggcgg uuutuuattg gtcggguucg 960
gcgguuaatu utcgaagguu uaggcggagg cgggggcggu utgtggggaa ucgaggtgcg 1020
ggcggcgagc gagguagucg ggtguttcgu agcggagutc gaggututgt aguauuuagt 1080
tggauuuagt cguuuaggua ucguucgcgu uucgcggucg tutuutgcgu utuuuagagg 1140
agggagttcg aguatuuuuc gcggcgguua utuutcgggg uuaggagcgg ggaagcgaag 1200
<210>150
<211>1200
<212>DNA
<213>智人
<400>150
gatutuaggg attgaaatut gtuutaggtg tguauuagaa agtggtggua agagatgaag 60
uttcggagga ggutgauutc gguuaggatt uttaagtutu aaagtttuag utttutuauu 120
uutuaacgga uatgaaatut auutatttgt aautuuaggg aagtaaatga gataatgttt 180
ggaagatatu tagtutauua gutgutuagg cggggggcga aggttutgtt uuutgtuuut 240
tututatuaa atggutttaa aatuagaaga aagtattacg ggtaggaaat gggautgcga 300
aaaaaatgga ggutgattut gguutaaagg atauttatut utatauaaag gguttutgat 360
tuaaagaggu uucgggattu aaaaauauaa guagagutau auuacgtggg gtttgggacg 420
agutgaattu cggataaaga tguutgtaaa gaggagttga tgcgaatuua gaaaaguaut 480
tgaaatguuu aggutttgua tgguauattu uuuaggattt tttcguaucg uatttagagg 540
tttagacgga gtgagutcga atuagguuaa aaguuttagg ttautuutgg gcgguagcgg 600
gguagaggtu agatuaauag gtgtggaagg utgcgaggtg agggaagaag uaggtgtcgg 660
tggagguuuu agttuutucg guuuagaggu tuuaacgutg utattggtgt tuuaguagcg 720
ggcggagggg tuutguucgg uatutgggcg cgutggguuu agaguucggg aggagguaga 780
cggaggcggc gggtuagcgg cggguuaguu ucggtgggut tucgutuuuu tucgucgguu 840
cggtucgguu cgucgcggag gatguutgga ggttgacgtg aatgguutgt ggutgggaag 900
uuuuuaggcg uuutguutag uucgggggcg gggucguuta gucgucgguu ucggtggcgt 960
gagggutggg gcgggggucg gggauutcgc ggggagggag cgggagggaa agcgguuuuc 1020
gcgguuuttu aattggucgu aucguuuutc ggcguagagg cgggaggagg cgguuutuua 1080
ttggtcgggu ucggcgguua atuutcgaag guuuaggcgg aggcgggggc gguutgtggg 1140
gaaucgaggt gcgggcggcg agcgagguag ucgggtgutt cguagcggag utcgaggutu 1200
<210>151
<211>1200
<212>DNA
<213>智人
<400>151
gggatggagt attguaguut utcguuuuau agauttgtga auagggcgtg gggauagaua 60
uuuagutuut aggguuatgu uauuuuuauu uutguucguu tutcguagua uutttuutgt 120
ggatutgauu uuuttuuaga uauagaagta aguuaguauu uaguagauau agggtuauut 180
uuuagutuuu tauuagguaa gagcgauuag gguagggaut gatautgucg aauuuaggag 240
uuagguucga uuuaguutua ggtuuaguag gtuucguutg tuuauutggg uuagguutag 300
aguucgggag uuuutggutg gtgggagguu auucguaauu uauuuuauac guagutuuag 360
utuuuuuauu aggcggggcg autaggauag ggauagaauu cgttgaauuu aggagtgaga 420
tucgguuucg ggtuucgutg gguuutuucg tuuauuttgg utggauutgg cguutgggag 480
auuttggutg gcgcgagguu acguuuauua gauatguagt tuuagutauu uuauuagutg 540
ggcgauuagg auagggacgg aggutgutga guuuagttag agguutguuu uucggggtut 600
gtuutgggcg utuuuuuaag gacggauagg guagguaggg tucgggacga tggucguaua 660
gtuucgguuu cgtgttuuua gguucgtutt gutuutcgat gtgagggaga uucgggggat 720
gggauaggut ggguuucgua gtguutgaut uuutguaggg utuucgggau aggggtucgg 780
cggauagucg gutgutuacg ggtgaggggt uuaagutggu attgcgguua uuttucgguu 840
cgggututut tggggagggg cggggttggt gagaaucggt uacgtgutuc ggggutuaut 900
cggggtutuu uagggucgga agtaggguuu utgtgcguag gcguuutgag gatuucgggu 960
tguuuatutu acguuagggg gcggaauttu utguaguutu tutguutucg uatuutcgtg 1020
gguuutgauu ttutututga gagucgggua gaggutucgg aguuatguag gucgaagguu 1080
aggguauagg gggttcgacg ggcgatgutg atgguuuagg agguuutggu attuutgatg 1140
guuuaggggg uaatgutggc gguuuaggag aggcgggtgu uacgggcggu agaggtuuuu 1200
<210>152
<211>1200
<212>DNA
<213>智人
<400>152
ttguaguutu tcguuuuaua gauttgtgaa uagggcgtgg ggauagauau uuagutuuta 60
ggguuatguu auuuuuauuu utguucguut utcguaguau utttuutgtg gatutgauuu 120
uuttuuagau auagaagtaa guuaguauuu aguagauaua gggtuauutu uuagutuuut 180
auuagguaag agcgauuagg guagggautg atautgucga auuuaggagu uagguucgau 240
uuaguutuag gtuuaguagg tuucguutgt uuauutgggu uagguutaga guucgggagu 300
uuutggutgg tgggagguua uucguaauuu auuuuauacg uagutuuagu tuuuuuauua 360
ggcggggcga utaggauagg gauagaauuc gttgaauuua ggagtgagat ucgguuucgg 420
gtuucgutgg guuutuucgt uuauuttggu tggauutggc guutgggaga uuttggutgg 480
cgcgagguua cguuuauuag auatguagtt uuagutauuu uauuagutgg gcgauuagga 540
uagggacgga ggutgutgag uuuagttaga gguutguuuu ucggggtutg tuutgggcgu 600
tuuuuuaagg acggauaggg uagguagggt ucgggacgat ggucguauag tuucgguuuc 660
gtgttuuuag guucgtuttg utuutcgatg tgagggagau ucgggggatg ggauaggutg 720
gguuucguag tguutgautu uutguagggu tuucgggaua ggggtucggc ggauagucgg 780
utgutuacgg gtgaggggtu uaagutggua ttgcgguuau uttucgguuc gggutututt 840
ggggaggggc ggggttggtg agaaucggtu acgtgutucg gggutuautc ggggtutuuu 900
agggucggaa gtaggguuuu tgtgcguagg cguuutgagg atuucgggut guuuatutua 960
cguuaggggg cggaauttuu tguaguutut utguutucgu atuutcgtgg guuutgauut 1020
tutututgag agucggguag aggutucgga guuatguagg ucgaagguua ggguauaggg 1080
ggttcgacgg gcgatgutga tgguuuagga gguuutggua ttuutgatgg uuuagggggu 1140
aatgutggcg guuuaggaga ggcgggtguu acgggcggua gaggtuuucg gggcguaggg 1200
<210>153
<211>1200
<212>DNA
<213>智人
<400>153
ttgtgaautg uutgtggaua ggguaauatg guagagaaut gaggguagut tttataauaa 60
attaagagat ttuttaatat ttaauuutuu ttauattaau tgutcgtggt atattattut 120
ttttaaaaaa ttatttatau tttttgtggg tauataatag gtatacgtat ttattggata 180
uatgaaatgu tttaauatag guauauaatg uataatgatu auataatggt aaatggggua 240
tuuattuuuu tuaagcgttt atuutttgtg utauaaauaa tuuaattata uttttagtta 300
tttttaaatg tauaattaaa ttattttgau tgtagtuatu ttgtgutatu aaatautagg 360
tgttaataat uauatuatgg agaatggagt atuuatuuut uaagcgtggt guattautut 420
ttgaatatgu tgututggat tgtatttgut aatatgtggg guttututat taatgttgua 480
aaatagggag uuaataatut ggttgagaga tgaaaguagu aguaggaaaa tgtgttuaua 540
gaauutuata cgagtggcgt utaggguuaa ggutuuttga atguatauuu aagggutgat 600
gagaggtggg gacgagtgut gucgaaggau tuutuaauta uuagaautac gtaggguuuu 660
taauatuuuu tcggagcgag utuuucgcgu uucgtauauu auuaggtutu uutggttuut 720
utuutgutuu ucgtuucgut auutuaggaa autttaguuu aguututucg atauaagucg 780
guutuuttga gggutttagg uuuututtcg uuagtgtata uuuuacgaua cguutgcgta 840
utagggauua uucggutttg tgggcggagt uuatgagagg gttggaguuu cgutcgtggu 900
uucguuuauu uaaguutagg ucgguuttcg tggauacgua tttucggcga cguutcggta 960
utgauututg uagagucggg tggaguuuat tgacgtuuag cgaagcgagg aguagcgatg 1020
gacggtcggg tguagutgat aaagguuutu utgguuttgu cgatucgguu tgcgacgcgt 1080
cgutggagga auucgattuu utttuucgag acgtttgacg gcgataucga ucgautuucg 1140
gagttuatcg tguagacggg utuutauatg ttcgtggacg agaauacgtt utuuagcgau 1200
<210>154
<211>1200
<212>DNA
<213>智人
<400>154
tcgaatutgu agtgagtgat cguauuautg uautuuaguu taggcgauag aggtuaaaaa 60
uaaaauaaaa gaaaauaaau aaaaaaaaua taguaaauat uuagaagaut gtgtagagua 120
atgaatgtut utuaaguuag tgatuttttt ututtuattt ttuauatuag gtgggtagtg 180
tguuuauttc gtaauaaggt ttgagggagg uauatttgau auaagaguat gaaaauuuaa 240
tuauauttat gauttauaaa aggatuaagt uagtgatutt taagutgtgg guuattaaat 300
auattttgtg agucgagtgu agtggutuag guutgtaauu uuaguautat gggaggtgga 360
ggtgggagga tuauttgagt uuaggagttu aagauuaguu ttggguaaua tautgggaau 420
tuuuatutut attaaatttt ttttttttaa ttttgtggat tauaauuatt tuaaaaauta 480
aaataagcgt aaatgtatua aaatguagut tauatagcga ggataaatgu tgttttgtua 540
atutgttgtt tuaagttttt tatgtgtgga ttgggtuauu ttgtaauagt gauttauutt 600
tatgggtuac ggttgaaaau atttucggtg uagtggutga utgtaatuuu aguautttgg 660
gaggucgagg utggaagatu auttgaaguu agaaguuaag agttuaagau utguutgggu 720
aauacggcga uauuucgtut utatttaaaa agaaaaaaaa aagtttuuaa gguautgaga 780
tguuaggaau ucgaggtgtg tgtuuagtag gggagggagu aaattgggcg tttggaaaaa 840
gtuuuacguu tggaaaggaa tauauagtgg gggggtgggg ggcgggguau atcgautaut 900
tuaagguaua utuuuacggt tuagaaaauc gattggutaa aautgggaaa gtuucguuua 960
uaacgutuau tgguuaatgg utgcgtgaaa tuagtgcgaa gtgggcggga tagagagcgt 1020
gggcgggggg gutaguutcg tgcgggutuu ttaagtagcg gutgcgtggu ttuuutggua 1080
cgutaututt acgacgtuac ggtuaggtgg tguagagutg gacgguaacg acgtcggacg 1140
cguuuuttut tggaauaatg tuuuauuacg gaggagutuu uaagguutut acgtgggtcg 1200
<210>155
<211>1200
<212>DNA
<213>智人
<400>155
uutuuagttc gguattagtt tuttuutaat gtuuaututg uucgaagtga uaagcggggg 60
uatgtggaga utuagutuua ggttuutgga cgggutuagu uauuuuuaga aagutaatga 120
atgutuaauu aggguttuua gatguuuagg ggauagagua ggagatgucg gggaatgggg 180
utttuuttgu agttuaggag gguuutguuu uagguuuaga agtagaaggg aaagcggutg 240
ttttggcggt aaauagtaat gtggggagtg utguagagaa agguagtutt ggggtttuaa 300
gutggagagu agtuagutau autuaggauu tutgguuatu uutguuttua uutgutgttt 360
gguutgatcg tutaauttut utgattutuu autauuuaut uuttattacg tttttgagau 420
ttgtuaaagt tttatattag ggutaautgg gacguataua aatutggtaa uttcguuagg 480
gcgggaagtt aggaaggagu agagutggut guaggtgtut ggtuutgauu autuututat 540
guuauuuttg aggaguttgu tgautttutu atgacgttut uuuattuuag gagutguaag 600
tgcgttatuu tggutggagu acggtgtuaa tuacgguaga utaagguuag cggtgatggu 660
ttgaatguua ggutgggggu tgggattttt uutgaggatt tuauaggaua gaggttggut 720
tggaaagauu aaggtgggau tgaggaauat tuuuuutauu uuuaauutcg gtgggutgtt 780
guaaguutgg agguuagaga agacggguut gggatgucgc gggcguaggg guagguagtg 840
aaggagatgg utguuttcgg tagagutggt cgutgaggua gaagaggagg gcgtggggcg 900
tggggcgtga ggtggucggc guuucggutg guuaatgguc gggutgcggu uuutucgcgg 960
ggcggggtgg guutggtggg cgggcggggu tcggggcggg ggcggagagg gaguutggtg 1020
ggcgggcggg gcgcgtuttg cgggutuuut cgggtaucgg cgutgucgua uuucgucgcg 1080
utuucguauu cgcgguucgu uuaucgcguc gutuucguat utguauucgu aguucggcgg 1140
uutuucggcg ggagcgagua gatuuagtuc gguucguagc guaautcggt uuagtcgggg 1200
<210>156
<211>1200
<212>DNA
<213>智人
<400>156
guautauagu utgggtgaua aaguaagaut utgtutuaaa aaaaaaaaaa aaaauaaaaa 60
aaaauaatta atguuutcgg gtaaautatg acgtttgtgu taauttttua gatgtuuuaa 120
gatttgggtt gttttauaag gataacgaag ttuatgatga ggttaaguaa tuautgaagu 180
tagtgutaga aatttttttt aatttaattt tttagaaaga ggggtuttgu agaatttttt 240
atttaatttt ttagaaagag gagtutcgut atgttgutua ggttggtutu uaautautgg 300
gutuaagtga tuutuacgag tagutagggu tauagguaua ggauautatg uuagguttag 360
tgutauaata ttutgtutat tttautttaa aatattutaa gtatgutuau tttggaaggu 420
atuaauatuu agaaatguat tuutauatua agaututuaa gaaacgggaa ttautgtaag 480
gguatauuut tgaguaauua tuauautgua utgaaututt gagaatattu tggaatatuu 540
tggaaguatu tutguagggu agagaagtga autguuauag aaggaguagu tttggggaga 600
agaaatauag tttguututt auagtatttt tutauaucga gagutauatt uutuucgagt 660
tttaaatttg tggaucgttg aatatuautu cguutttuat aaagttauaa atauuttucg 720
tcggtggcgg gaauagagtt tggaaaatta uatguutaag auttuagata agutaaatga 780
uatauatgua ataguatuuu atgaagaatt tattuaauuu aatuuattgu atutaattau 840
uuaaaguaua gaaaututuu aaautgtgua uuuuuuaaaa ggagggaaaa tguaaggttu 900
utgutguagt tuucgggaua uautgcgagu cgutttgtta uaagtgtatu uaatgtuuuu 960
agaacgaggg auttgtgggg cgcggutuat uuuagcguua uttgututgu agutuuuaga 1020
ggtggtggtt gtgttacgaa ggutgauuut guuaatgguc gauaaaatgg tgcguauuuu 1080
uaagtgutcg agatguagga auuatggutt uutggtguuc gtuaagggau acgcggguaa 1140
atgucgutgg aaguagtguu tutgcgagaa gtgutauutg atutucgagc guuagaagat 1200
<210>157
<211>1200
<212>DNA
<213>智人
<400>157
atatatatat gtgtttatat atataatata tattatattt gtatauauau auauatatat 60
guuauatttt utttatuuat ttatuuuttg atggauautt aggttgattu uatatuttgg 120
uaattgtgaa tagtgutgua ataaauatga aagtauagac gtututtuaa uauautgatt 180
tuaaatuttu uuagtaaata uuuagaaatg agattgutgg atuatatgat aattutautt 240
tuagtttttt gagaaauutu uatauaattt tuuatuatgt ttgtautaat ttauattuua 300
uuaauaguat auaaguattu uuttttutuu attuttguua auauttgtta tuataaaggg 360
aggtttgaga gauuataaaa uaaauuuuau utuauaattt tgttagtgua agttutattt 420
gguutattuu uaauautaag uauauagtag gtgguaaata tttgttgaat ggatgaattu 480
tuatttttut uuatttgtgg aaguagauau utuutuaaaa aaaaaaaaaa atucgaaaga 540
aaaggtaaag gaaauagttu tatgaatggg ggttaattta ututuutagu attuauttat 600
tgggaaaaaa agtaauagua gtttutagaa uuututggtu tutgagggag atgutgtgtt 660
uuuutuutua gagaagaaga aaacguauta gagagtggga guatuuuuaa ggutgaagcg 720
uatuuaggau atuauatgtu aacgtgtuut ututggcgtg gggtuuucgc gagtutggga 780
aacgaggagu tgguaaggga ggguaagcgg gggcgguaaa gaggguuuut ggaguagggg 840
gcgcggauut cgutgcgutg cgcgututau cgucgggutc guaacgutgg gutuagcgut 900
cgcguutuuu tuagututut uutucguuuu uuttcguuut uuuuutttuu utuuutttut 960
uutuutuutu utgucgucgc ggucgutguc ggauttcguu agatuagauu uacggggutg 1020
uuutuuuutg cguautuuuu tcgutguucg gguucggagc guagcgcggu cguauaggta 1080
ggaguuuuua acggggggtc guuucgagcg aguuuagtau tuautggguc gcgcgcggga 1140
gagtgaggtg gggtgagutg aggggtgttg agtauucgag aautguuutg gautgtguag 1200
<210>158
<211>1200
<212>DNA
<213>智人
<400>158
gagaagutut gagauatgtg agaaggtuta gtattutaut agaautggaa gattgututu 60
cgagttttgt tttgttattt tgtttaaaaa ataaaaagut tgagguuaag guaattuata 120
ttggutuaua ggtatttttg utgtgutgtg uaaggaautu tgutagutua aggtgagtat 180
autgggaaag uuttaacgtt utagagaaua gagttttgua guuuuauutu uatuuuucgg 240
ggtgtgggau tgggggguag gaaatguauc gtuuuutttg aaatggatta utgttttttu 300
utttcgauuu uututttutg uaguutgutt tgtaggtgua gtataaaatg uacgutgaat 360
gtuttttgta tgtaaauagc gtaguaggat ggagtaacgt gaaatguaat tutauaguag 420
tttttacgtu tttgutguut cgttcgttgg utaucgagaa ggttuaggag ggggagggga 480
gatgagaaag uagattggaa gttgagtatg gtggaguutu aguututuuu auuutuuttt 540
uutcguttgt gutuautgut aaagttttgt tautttuuuc guaguagata utaaauatta 600
gtttgtuutg tattttuttt gagattuaua atgttgaaag uuuttttuut aautatgutg 660
aututggcgu tggtuaagtu auaggauauc gaagaaauua tuacgtauac ggtaaggggt 720
gatggaattt gaaataagta cggttuagcg ggattutgtg auaaaaaaag autttauaua 780
uuuutguuag tgtatttggg utataututg utgagggtga taaattaaau aauauttuat 840
tuatguttua tatutaagat tcgttgtaaa ttguuuuutt gatuutttua aaagttuatt 900
gggutuauua uutaagatag gaauuaauat gtaatuattt gtguagggut aaaaatggga 960
tucgttuaaa aautaaaauu aaagaaagtt auatgtttuu aaaauattua auaaattaat 1020
gggtgtaagg aautggaaaa uutggautuu tauuauatgu agataaaauu aatacgtgua 1080
gaataagaut uaagtuaagt aagaacgtta aauauuataa agauauatgg uuttutttgt 1140
gtauatgaua tguattutua agtaagtggu utttattgaa tttataaagg utatatattu 1200
<210>159
<211>1200
<212>DNA
<213>智人
<400>159
cggutaggtc ggagcggaga gtcguaguag ucgutucggg uaguttuuua gtuucggtut 60
guuttgtutg tgcggutgua agtuuucgua uuuauautta aguutttuau ttutauuuua 120
ucgutuuuag acgggutagg uucggttuua gggautguuu uuaauuutgu uuucgggaaa 180
tuuauaautg gttuuutguu uaagguuatu tcggggcgtu utggguuutg ggcgaggtuu 240
acggcgtgtg uagggggacg ggguuagcgg ggauttuutt autgutagaa agtuattcgt 300
tuagtututg gagauagtga cggaguuutg utgcggautg gacgttgggg auuaagtagg 360
tuuucgutut uuagguatut ggggaguuag ggaagaagcg agtgatagag uuauaaaaut 420
uuucguaaag agtatttuag agggggaagc guuataaaga uaaaauaggg uaaggtggua 480
gagggtggcg gtgguaggcg cgagtutgua gutuaguucg ggcgcgutgg acguagauac 540
gtcgaututu utaaagaagu aaucguaggt uaguttagau ttuttttatt tuaataaaag 600
agcgttttuu tuuatuttaa aucguucgtg gtgggagaaa aggtttuuaa uututtutut 660
ggutuuuutc ggtuaattuc gaguttttuu aaagtuuutu cgucgtuuag gggutcgauu 720
ttcgaggtaa cgtgggggat uucgutggut uuutucggua ggcgggggcg gggaucgguc 780
gtgutcguuu uutagaguuu cgggagaucg cgcguuucgt ggaguucgga gggggcggaa 840
uuutggggcg gguuutgutc ggtgaaggcg gggutcgguc guuutgtutg cgucguuatt 900
ggucgcgggu uucggautgg cgggutuacg tuaucggucg gguucguuuu uttgguaatg 960
tuttuaguuc gutgututuu taauttaagu atttattuua utgggataga agcgguagga 1020
guagcgttgg uaucggcgaa uuatggutgg gattttutat ttcguuutat tttcgtgtut 1080
uttcgggatt tgcgacgutg tuauaggttu uagggtatau uucgcgaatg aaggtaagag 1140
cgggacgguu tttutgtggt cggggauagc gagggguuat cgcgggtgag gggtuutuag 1200
<210>160
<211>1200
<212>DNA
<213>智人
<400>160
aauuutgtgg agatagguaa aataagtata auuuuatttt auagttgagg uuauuuautt 60
aataaauaag tgauaaaguu aagtttuuag tattuutuaa gtgttttuut ttuaggutut 120
aaattgutga uttaaatgtu atuattagag agagttgtut uutcggtaga agtauaaatt 180
ttgttuuaga gtuaaatatg aagauttgat uagtgguutg gcgcggtggu tuacguutgt 240
aatutuagua utttgggagg uuaagguagg cggatuauut gaggtcggga gttcgtgauu 300
aguutgauua auatggagaa auuucgtutu tautaaaaat auaaaattag utggguatgg 360
tgguauatgu utataatuuu agutautuag gaggutgagg uaggagaatc guttgaauuu 420
aggaagutgt ggtggcggtg aguuaagatc gtguuattgu autuuaguut gggtgauagg 480
agtgtgaaau tutgtutuaa aaaagaaaaa aagauttgat uaguttatag uutttatuat 540
utagtuttut attututgga gagtuagtgg ggaututtuc gagttuttgt aguuttttut 600
taagguutat aggaagtuat utgtgutgag uutguauttt utataauaga tggaaaautg 660
aagutuagau atuttaagtg guattgautt agautataga gutagttagt gggggguuag 720
uauuatgauu tgguuuutau utuuaguagg uttuauuuau uuttguauuu ttguaggaag 780
uauttagagg uttgaggttg uuagutgtgg ggggttgggu utgtguagtg uututuaguc 840
guuuacgutg gtggggutut guagtgttag uttuttgttt ututattttu tauutaggtt 900
tuagtttttu auttgggttt gtttuuuutt tgtututggt tuaguttuut tttuutgttt 960
ggttttaagt aggutataaa aatuaagttg utgtuttuag agggtutgtg gtuututgat 1020
uaauataggu tggtgggagt auaggautcg uutuutuagg gttuuutgtg utguuauttt 1080
tuaguuatgg uuauaaggtg agtattggaa uuagtguagg ggauagaggg atgtuaagag 1140
gaaauutaga atuttaacgg tgaatgggut gtagaaatta tutuaggtuu uuttagtata 1200
<210>161
<211>1200
<212>DNA
<213>智人
<400>161
uttttaaatt tgtttututt uuuutttttg ttaaagtaua aaauaaaaua uuttuuuuua 60
uttttcgaat agttttggut gtgtutttag gautggaagg aaattuagut uaaatgaatt 120
autatattat gaauttaagt aagaattgtt gtguattttg tauagaatgu aautuutagg 180
agttgauaaa tgtttgttaa gtguatuagt gagcgauata ggauuttutu utuuutautu 240
tuttgtuacg gtttttattt aatuaaauat ttattattgt tcgatgutut taaatguuat 300
ttuuttuagu tgattatttg tatgauagaa gagtuaatta agutattttg tuutaaaaat 360
tacgaaaacg aaatgtauaa ttgtgaagta aaattttgtt uutttguaaa ttttaataaa 420
ttattgaagt ttattttttg tttuaaataa tutggguttu agttutaata atggaaggau 480
aatgtgaagg uuuagaattu aguatagcgu utgguattaa taggaggtua gtauattttt 540
agtauatgtt tutuaaatag atuttaaaat ttuatttaag agcgtttuut uacgtuauag 600
tatgtututg gcgttautta attttgaaaa auutuaauau agattutagt tttagguaaa 660
gutuagaaaa tttutautta aggatatttu uaaagcgaaa ggaagcgcgg agacgttuat 720
gautgguatu atutcguacg tggttucgga aattutcggt aggatguuut auatutgutu 780
tuuutuuaut aagaagaauu tutttgtgtg gcgaaagtaa aagtattagg guttttaagt 840
tguuuagagt uaaggaauac ggataaagac gutgggagat tgauatguat ttcgauuaat 900
aguattguag agaggcgtat uatttcgcgg atgttuuaat uagtacguag agagtcgucg 960
tutuuaaggt gaaagcggaa gtaggguutt cgcguauutu atggaatuuu ttutguagua 1020
uutggatcgu ttttucgagu ttutggcggt utuaaguaut auutacgtua guauutggga 1080
uuucguuauc gtgcgucggg uuttguagtg ggcgcgutau utgcguuaua tuuatcggcg 1140
utttggtcgg uatgguuuua ttcguacggu tutggagcgg cggutguaua auuagtggag 1200
<210>162
<211>1200
<212>DNA
<213>智人
<400>162
guauaggutg uuagutuagg utttgguuuu tuuatucgut uutgguttut utgtgggtgg 60
uuuuatutaa guuaatgggu uuttuutggu tuuauutuut ututgutgtg cgguuutggg 120
uagguagutg uuutguuutg tguutttgut uttggutguu tuauuuutgt uutgggutgu 180
agggagauuu utgggggtgg ggguagguau autttggguu uatggutgut gutuagatgt 240
gaggtggtga uuauuagguu atacgtutut ggauagggat gggagagaut uagagagaua 300
uagagauuaa gagataaagt uagagggaga tguagagauu aagagggaua aauuaaggga 360
gauagagaga tgauattaga tuagagatgg agauuucgaa agagauuuag aaagggatcg 420
gtgtgggutg ggggaagaga uauuucgggg gtuauauagt ggtuauaggu atuagagutg 480
ggutgaggaa aaggauaaau tgaauutgtt uuaaagutgg gggutuagta ucgtutguuu 540
agguauatgu aguaguagtg gggutguagg uagguuuuua gggtaggaag uaaggcgggt 600
gggagguagg guutgguutu tggguagttt tgtagucggg uuuutuaggu uutuauaatg 660
tguuuaaggu tgutggguuu atuttuuagg ggtgatuaut gaggutuagg utggutgagg 720
tggucggauu uuaauuuutg guuutguuut gtggguagua gtguuaggtu tgguautuag 780
aggttagguc gggcguaggg agggtgcggg utucguagcg agcgcgucgg gcgguututa 840
ggagucgggt uagcgagtut gggututgag cgagcggcgu cgguucgguu uuututucgg 900
cgggcggucg agauuucguu ucggaggcgg aggcggagtu aggggagggg gucggggguc 960
ggutggtuuc guututcgcg uutucguuuc guuucgcgcg uauauaguua ggggucguuc 1020
gggututcga cgcgucgacg gucgggcgga cggacggacg gacgucgagc guagtguuuc 1080
gcggtgagtg uacgcgguuu utuucguucg gautuatuuu cgtcggtucg cguutcguag 1140
utuaggautc gggggcgutc ggacguaucg acggutcggc ggauuutcgg acgcguutcg 1200
<210>163
<211>1200
<212>DNA
<213>智人
<400>163
guauaggutg uuagutuagg utttgguuuu tuuatucgut uutgguttut utgtgggtgg 60
uuuuatutaa guuaatgggu uuttuutggu tuuauutuut ututgutgtg cgguuutggg 120
uagguagutg uuutguuutg tguutttgut uttggutguu tuauuuutgt uutgggutgu 180
agggagauuu utgggggtgg ggguagguau autttggguu uatggutgut gutuagatgt 240
gaggtggtga uuauuagguu atacgtutut ggauagggat gggagagaut uagagagaua 300
uagagauuaa gagataaagt uagagggaga tguagagauu aagagggaua aauuaaggga 360
gauagagaga tgauattaga tuagagatgg agauuucgaa agagauuuag aaagggatcg 420
gtgtgggutg ggggaagaga uauuucgggg gtuauauagt ggtuauaggu atuagagutg 480
ggutgaggaa aaggauaaau tgaauutgtt uuaaagutgg gggutuagta ucgtutguuu 540
agguauatgu aguaguagtg gggutguagg uagguuuuua gggtaggaag uaaggcgggt 600
gggagguagg guutgguutu tggguagttt tgtagucggg uuuutuaggu uutuauaatg 660
tguuuaaggu tgutggguuu atuttuuagg ggtgatuaut gaggutuagg utggutgagg 720
tggucggauu uuaauuuutg guuutguuut gtggguagua gtguuaggtu tgguautuag 780
aggttagguc gggcguaggg agggtgcggg utucguagcg agcgcgucgg gcgguututa 840
ggagucgggt uagcgagtut gggututgag cgagcggcgu cgguucgguu uuututucgg 900
cgggcggucg agauuucguu ucggaggcgg aggcggagtu aggggagggg gucggggguc 960
ggutggtuuc guututcgcg uutucguuuc guuucgcgcg uauauaguua ggggucguuc 1020
gggututcga cgcgucgacg gucgggcgga cggacggacg gacgucgagc guagtguuuc 1080
gcggtgagtg uacgcgguuu utuucguucg gautuatuuu cgtcggtucg cguutcguag 1140
utuaggautc gggggcgutc ggacguaucg acggutcggc ggauuutcgg acgcguutcg 1200
<210>164
<211>1200
<212>DNA
<213>智人
<400>164
uucguuuutt uuuucggaga cgcguuuauu cgguuaucgu tututtuuua utuuuuuatt 60
auucguaguu utuautuuuc gutgcgggaa ggggutgutt ggutguutut gggggtuttu 120
agagutauuu tggtuucggg ggattggagg aggaggttau utatuutgcg tcgtutttaa 180
tucgtguauu autatuuatu aaatagagau agatuutggg uututuaaag acggatgatt 240
gggggtggtg attgguutat uuutaaatat utauuacgua aggaututtg agagatuuag 300
auuucggtau agtcgaggga uutgggguuu aaaaagggaa agcggutauu tutauuauau 360
agttgggaag cguagtuuta aaggagacgu aggttggaga utucgutaag cggagaaguc 420
guagtggggu uatgguaagt uauuttuuut ttcggguuta ggaatautua ttcgaaagat 480
ggggggautg gagtgucgag tggutgtggu aguuacgatt ggggtttgga aauuatuutg 540
aaagguucgg ggaguuagtu tuutggaaut tutuuutuuu uattuuuaua aaaauuaagc 600
guuututcgg uuaattutua uuututuagg auaaaaaagt gagatgaguu cgtuutttua 660
uutgcgagtu uaaguuuttg guagagguut gaaaagtucg aaaautucga gttcgggcgu 720
tgaggtutuu cgagucggtt uutgaautut ucggguutua gtcgatcggg gtgcggaggg 780
ggucgauucg ggggatutuu aagcguuutu uucguuutga cgutgtgggg utuutaucgc 840
gucguuauag utgutuutau utggggaggt gcguucgggu uucggggggc ggguagtcgg 900
ggggcgggua gggaaucggt gucguuuuac guttcgtggu uuutttaagg aggggaaguc 960
ggcggaggga ggagucggtu cggtgtgtgu aggggagcgu utcguuagcg gtucguaggg 1020
utggagauuu acgucgtgga gaggauuagu utuaggtcgu uucguutggg uucgcguuuc 1080
gauutcgutg uuuucguutc guutututgu ucgtggcgut tacgguuauu ttgguutcgg 1140
ggguagggua tgggcgguuu ucguuagatc guuuagcguu agtautaaut guuutcgutu 1200
<210>165
<211>1200
<212>DNA
<213>智人
<400>165
ggttauutat uutgcgtcgt utttaatucg tguauuauta tuuatuaaat agagauagat 60
uutggguutu tuaaagacgg atgattgggg gtggtgattg guutatuuut aaatatutau 120
uacguaagga ututtgagag atuuagauuu cggtauagtc gagggauutg ggguuuaaaa 180
agggaaagcg gutauututa uuauauagtt gggaagcgua gtuutaaagg agacguaggt 240
tggagautuc gutaagcgga gaagucguag tgggguuatg guaagtuauu ttuuutttcg 300
gguutaggaa tautuattcg aaagatgggg ggautggagt gucgagtggu tgtgguaguu 360
acgattgggg tttggaaauu atuutgaaag guucggggag uuagtutuut ggaauttutu 420
uutuuuuatt uuuauaaaaa uuaagcguuu tutcgguuaa ttutuauuut utuaggauaa 480
aaaagtgaga tgaguucgtu utttuauutg cgagtuuaag uuuttgguag agguutgaaa 540
agtucgaaaa utucgagttc gggcgutgag gtutuucgag ucggttuutg aaututucgg 600
guutuagtcg atcggggtgc ggaggggguc gauucggggg atutuuaagc guuutuuucg 660
uuutgacgut gtggggutuu taucgcgucg uuauagutgu tuutauutgg ggaggtgcgu 720
ucggguuucg gggggcgggu agtcgggggg cggguaggga aucggtgucg uuuuacgutt 780
cgtgguuuut ttaaggaggg gaagucggcg gagggaggag ucggtucggt gtgtguaggg 840
gagcguutcg uuagcggtuc guagggutgg agauuuacgu cgtggagagg auuaguutua 900
ggtcguuucg uutggguucg cguuucgauu tcgutguuuu cguutcguut ututguucgt 960
ggcguttacg guuauuttgg uutcgggggu aggguatggg cgguuuucgu uagatcguuu 1020
agcguuagta utaautguuu tcgututggu uttcgaguuc gaaguututt utgcgcguau 1080
aauutaggua gtaatuutaa autagcgggu auuauagauu agutguaguu auuuuaauuu 1140
agggatuaut tucggauuuu tcgaucguuc gguauuagcg cguaagggau uuttuagucg 1200
<210>166
<211>1200
<212>DNA
<213>智人
<400>166
utgacgauta tttuuagaga tuututuuuu tguuuuattu uaguuuagtu aututgagag 60
cgcgagggau agguuagguc gagguttutt cgtauagtua uauucgtttu tgggutgaut 120
ttuuuaaagu utuagaguag ututuuuuau uutauuucgt uuaguuuuut cgucgtutcg 180
uuuutuuuua guuucgagut agaagttuag uutuaagacg guaguaaacg guagaguaaa 240
ggagtcgttt tutttuauut gaaagucgcg aggagguttg gagcguuttt uutcgutggg 300
guucgagutt uutggguttt ggucgggtgc ggguagauuu uaucggggtu utcgtuatut 360
uuuaguuuag uucguagagc gagtaucggu agatttuaag ggcgcgtgag uutggutgtc 420
ggutggguuu utgaggutcg utgggcgggg guaggucggt uuaggutgtg cggggcgttt 480
auaaaaagtg auttggagat gaautcguuc gtgcgcggut ggucguuucg utataggggc 540
gaaggcguut gacguaagcg gaautcggtg gaguuuatac gaatuagaau agagcgaggu 600
tuutggcgua utagggautu uaggagguag utucguuaga gacgcgggtc gtguttcggg 660
aaaucggggg gcggggggag gggaagagcg uagaaaagaa aauuuauuaa ggcggggaut 720
gguutgagcg gggaggggcg gcgaggucgg aguuuututu tgttgggcgg autuuuuatg 780
guuagaggut gagutuuaut uucgucgguc gutuuutagg ggaaggggaa ggagagggga 840
gaguagcgau agguutuuag uaaguaagcg cgggcgguat ucguagtutu uagaagtttg 900
agauttgguc gtaagcggau tcgtgcguuu uaaututttg ucgcguuagc guutggagcg 960
gagaguagag gcgguucggu cgcggcgcgu cggutttgtu atgatgguua gutauuucga 1020
guucgaggac gcggcggggg uuutgutggu uuuagagauc ggtcguauag tuaaggaguu 1080
agaagggucg ucgucgaguu uagguaaggg cggtgggggt ggcggcggga uaguuucgga 1140
gaagucggau ucggcguaga aguuuucgta utcgtacgtg gcgutuatcg uuatggcgat 1200
<210>167
<211>1200
<212>DNA
<213>智人
<400>167
gaaaggagut uataggaagg gguauaguau aaggutuucg aaagaggtua utguaagtgt 60
uutgcguaat ttutgttuag uauututgua gtgacgauag gggtttgutt tcgtaaguag 120
uatcgttttu autautauag aaguauatac gucgcgtgua guttagguuc gaguaaagtu 180
uutgutuuuu tagauuuagt uuuttuaggt gtuuuuutag gggaautgtg gcgtgtuuuu 240
uuaauuaggc guautcguut aaautgcgtu uucgaautuu agggcguagg gaguuutcgc 300
gggutguucg gggutggggu uuauauutga acggaggagu cggutggcgg agcgguuucg 360
cgcgcguaua uacguauaut uauagauacg cguaaauuua uagcggcgcg cgcgutuuuu 420
attggcggga ggaggaaggc ggggucgguc gauuuaaaau aaauaauutg cguuagcgau 480
tttgucgucg cgutguagtg tgguutucgu utggtgcgcg uucgttgggg agutggggaa 540
utggggaguc guuauuauut cgguuauutc gttuuuuuau uuuttgucgt ucgcgutuag 600
guuucguuuu cgcggagucg ucguagggtt atattggguc gguucgaagg tggaggcgag 660
acguagucgc gguagguuag cggggagatg utguuucgga ggutgggagc gggaaggcgg 720
utgcgggcgu agcgguutcg gggautcguu tucgcgggtg utuaaggutg aaggcgucgg 780
auuttuuuuu acggtgguac guauatuatu cgguauuatt tucgtguuuc gaagacguuc 840
gcgcgggauu tgggaucguu agtgaagaau uuutuutggg ututttaacg aguaguagat 900
gcguatgutg uttututucg guaggaaagu uttutaaguu cggcgtgutc ggguauucga 960
gggtggaauc gcgguuuutg uauauautua uuuuaaagtu tuaacgtcga aucgaaggcg 1020
auauuuauuu aautuutuuu tutucguuuu atagtuuauu uaauauttgu aguuuutuua 1080
gagaaaaagu uuagcggaag aggautucgg aaaagtgaut atutcggaag auuagggtag 1140
agutuucggg agaaaaaggc gaagatuuuc gguuucggat cguuatuuuu ttuuutggua 1200
<210>168
<211>1200
<212>DNA
<213>智人
<400>168
gutuucgaaa gaggtuautg uaagtgtuut gcguaatttu tgttuaguau ututguagtg 60
acgauagggg tttgutttcg taaguaguat cgttttuaut autauagaag uauatacguc 120
gcgtguagut tagguucgag uaaagtuuut gutuuuutag auuuagtuuu ttuaggtgtu 180
uuuutagggg aautgtggcg tgtuuuuuua auuaggcgua utcguutaaa utgcgtuuuc 240
gaautuuagg gcguagggag uuutcgcggg utguucgggg utgggguuua uauutgaacg 300
gaggagucgg utggcggagc gguuucgcgc gcguauauac guauautuau agauacgcgu 360
aaauuuauag cggcgcgcgc gutuuuuatt ggcgggagga ggaaggcggg gucggucgau 420
uuaaaauaaa uaauutgcgu uagcgauttt gucgucgcgu tguagtgtgg uutucguutg 480
gtgcgcguuc gttggggagu tggggaautg gggagucguu auuauutcgg uuauutcgtt 540
uuuuuauuuu ttgucgtucg cgutuagguu ucguuuucgc ggagucgucg uagggttata 600
ttgggucggu ucgaaggtgg aggcgagacg uagucgcggu agguuagcgg ggagatgutg 660
uuucggaggu tgggagcggg aaggcggutg cgggcguagc gguutcgggg autcguutuc 720
gcgggtgutu aaggutgaag gcgucggauu ttuuuuuacg gtgguacgua uatuatucgg 780
uauuatttuc gtguuucgaa gacguucgcg cgggauutgg gaucguuagt gaagaauuuu 840
tuutgggutu tttaacgagu aguagatgcg uatgutgutt ututucggua ggaaaguutt 900
utaaguucgg cgtgutcggg uauucgaggg tggaaucgcg guuuutguau auautuauuu 960
uaaagtutua acgtcgaauc gaaggcgaua uuuauuuaau tuutuuutut ucguuuuata 1020
gtuuauuuaa uauttguagu uuutuuagag aaaaaguuua gcggaagagg autucggaaa 1080
agtgautatu tcggaagauu agggtagagu tuucgggaga aaaaggcgaa gatuuucggu 1140
uucggatcgu uatuuuuttu uutgguauua guttututag gutgcgcgaa ggaagagggt 1200
<210>169
<211>1200
<212>DNA
<213>智人
<400>169
gggautaata gatttattuu aggtgatagt gggaaguagu tauagaagga ggattggaag 60
gutgaggggt tgttaaagtt atutgatgat attgttcgaa uatttutucg guauagaaau 120
tuuauaaaga autuututgu agttttcgut auuuagggut gtttutttaa attgtttgac 180
gtuagagaag gaatgutata guaauagtut gtuaaautgg aattaautua gaagaaaaat 240
gggggtgggg agaggaaaaa tgutuuuagg cggtautgau ttuagaggaa guaaattgga 300
tagatguatt tattttatga uattttaaau ataaaauauu uagataaatg tgaaaaaaaa 360
aaaaautcga ttgagatgua tgtggtgttt aautuatgua gagaagagcg auttgguagg 420
gatatutgga agguuttuua gttttatuaa tgauaatagg aauaataaut tuuaagtatt 480
gguuatttat ttggagguag guttcgtgua aauatuautt uatttaatat guttaguauu 540
tttatgaggu aggtatuagt atutttattt tggcgatgac gaaauttagg uucgagacgg 600
tauacggtuu tauaautagt gatggaagag cggggautgu aacguaaggt tgtguaautu 660
tggguttuag tttautttut gauatttaga attuuagaat gggaaauuta aatgggguut 720
ttggggtutt utagututgu uuttcgatuu tgutaauaag uaaautggcg uutgtuagcg 780
ucggaaagga aautgguuac guuauttaga cgggcgutau ttaguagcgt guuucggcgu 840
uauauuaaua agaaaacgaa autguucggg aatgaatgtt tttuttutuu ttutgguagg 900
aaacgagaga gaaaatagga aguagaagut gcgcgcggcg uucgutuuut tcguuuuucg 960
uucgggutgc gcgcgutucg agggtutgcg cgtuuucggu acgtuuucgu cggguucgcg 1020
cguutcgtgu utcgcguutc gcguutuuag uuacgtuuuc guuucggutu cggcgcgucg 1080
cggagttggu tgutgggagg tgcgggautg ggtgtggucg gcggututgg tutcggutgt 1140
gagutgcgut utuuacgucg gutucgcgut uuaggggutg utgagcguuu agcggauauu 1200
<210>170
<211>1200
<212>DNA
<213>智人
<400>170
gtaauuagga atgatttgau tgtataaatt tatuttauag auauauttgt ttgtauattt 60
aatguutgut ttutataata tgaaaaaata uauagaacgt tttatguaat tggututgag 120
taatguaaua uataaatgut ttgagaguag ttauuaaaaa ttatguaggt tattauaaaa 180
gttatatgga attguauaga tattutaaat gtguttttga gtaaatttut uagutauuag 240
agguutgggu agutgtttuu aguauatuut gguauaauat tuatgttatu atuuauttat 300
gtattuuaua atttuaaatg attgataaga uauutuuuuu atutttgutt uututtggag 360
gaaaaaaata tauaaguaat uacgaguaua ggaguaggtg gauaautaua tuttaggaaa 420
gggtgcgtaa utgtgaautu taaacgtgag utgggtguut gatguagtat aggaauuaua 480
gtaagtcgat aatuagtgag gutggaggat tgaaatttta tttggtaaag aatattgagu 540
uaggcgcggt ggutuatguu tgtaatuuua guautttggg aagucgaggc ggguagatua 600
uaaggtuagg agatcgagau uaguutgguu aauatagtga aauutguutu tautaaaaat 660
auaaaaaatt agucggguat ggtggcgggu auutgtaatt uuagutautu aggaggutga 720
gguaggagaa tgguttgaau utgggaggtg gaagttguag tgagutgaga tcgtguuatt 780
guautuuagu utgggagaua gtgtgagaut uuatutuaaa aaaaaaaaat gaatattgaa 840
atagagtuta taggaaaaaa autuuttgaa tutagtaaat gtggaatuau aaaattgaaa 900
taatgtguat utgaaaagtg aataaataga tguuaagaag gagtgagtua taaguauatg 960
agttgtaaga ggttgaautt gagagauuag atuagguagt gucguttaat auuatuauat 1020
gatuutuuuc gagguuutgt atttaattaa aatagagagg gagguauuau agatguuaga 1080
agaauautgt tgututtggt ggacggguuu agaggaattu agagttaaau uttgagtguu 1140
tgcgtucgtg agaattuagu atggaatgtu tutautattt uutgggattt utgutuutgg 1200
<210>171
<211>1200
<212>DNA
<213>智人
<400>171
tuutauutuu utgguuautu uttttuagau tuutttgutg gtttgututu atttttuuut 60
aauutttaua tgttgatatg uuagaguauu tuaaauuutt agauutuatu tutgutautc 120
gtgutuuuat ggtgatutua tutagtutut ggtttuaaau auagagtgat uautuutgta 180
uttgutgttt uuuttttuut ggagttutut utguutuutg uaggtaggaa gtgattcgag 240
ataagagagg gagagaautu ttutgguuag gatagagggt gattutgaga agguttuaag 300
gaagaagtga guatttgagu acggutautt gaggaaggut agguuatgga uattagggtg 360
uagguaggag uagaguaaau atguttgtaa aaggaauagu aattattutg ttttatattt 420
atatuaguuu atggtgguuu uuauaguaga gtgguttgat ututuauutu uttuaggtut 480
ttgtttaaag attaauttut uuatgagguu ttutatgaau ataauuttta aaaauataaa 540
tuuuuttuut autgggautu uuuuagttuu uauuutgaga uuuuutatut ututtutcga 600
ttttatttut utuuatagga tgtgtatuau uauutgautt autagutatt tautatatat 660
tagtttattt uttuuuuatt agaatgtaaa uttuutgagg guagggattt tgtutgttga 720
gttuagttut gtatuuuuag uauutaaaau agtguutgtu uataauaggu atgttaaaua 780
ttgttggaua gatgaatgag tgaatgaaaa atggtagtau utttuutuut uuagtuuatu 840
utauauaaag agguaagatt aatttuuuta aatgcgtgag uattaggaag tgggagggat 900
tggaggagga aattataata aggaatuuat aaattautta aguuuataaa auaaaggtag 960
gaaauattua agataagaga uututtutgg uuaggataga ggttggttut gagaaggutt 1020
uaaggaatag guagauattt uaguaaggut gutgaggaag gataggutgt ggaaattagg 1080
atguaggtag gaggatuaua gaguaaauau tuuaaggtgg gaaatguaag tgtgtgtaga 1140
aggaauagua agtattgttg ggttgggutg guttatgaag ttgtgacggg utgagggaga 1200
<210>172
<211>1200
<212>DNA
<213>智人
<400>172
tgtgtatuau uauutgautt autagutatt tautatatat tagtttattt uttuuuuatt 60
agaatgtaaa uttuutgagg guagggattt tgtutgttga gttuagttut gtatuuuuag 120
uauutaaaau agtguutgtu uataauaggu atgttaaaua ttgttggaua gatgaatgag 180
tgaatgaaaa atggtagtau utttuutuut uuagtuuatu utauauaaag agguaagatt 240
aatttuuuta aatgcgtgag uattaggaag tgggagggat tggaggagga aattataata 300
aggaatuuat aaattautta aguuuataaa auaaaggtag gaaauattua agataagaga 360
uututtutgg uuaggataga ggttggttut gagaaggutt uaaggaatag guagauattt 420
uaguaaggut gutgaggaag gataggutgt ggaaattagg atguaggtag gaggatuaua 480
gaguaaauau tuuaaggtgg gaaatguaag tgtgtgtaga aggaauagua agtattgttg 540
ggttgggutg guttatgaag ttgtgacggg utgagggaga gauaggautg gaaaaguacg 600
ttggggtuag gttguagagg tuuttgautg auagagaggg gaguttggtu tgtggggaat 660
uttutgutut gtgtggtuag aggutggtut gaututucgg uuttguuuua gtuttuutat 720
uuttuatuua guuucggutg gutcggtaaa aacggcgcga atutcgutut uuutgggtaa 780
utagggtuuu uautguutgg utagtggtgu ttttcgcgtu ttuautggua uuattaatga 840
atgaagtutg gutuuuauuc gcggggaagg gaggaguutu aauutcgggt uutttgutut 900
uutguaguau tuutguucgg gtuucguutc ggggtcguua gguuutgaau uuuaacgucg 960
guattagtcg cguutgcgua cgguuutgtg gagucgcgga gguaagggac ggagaacggg 1020
gcggaggcgg agtuagggcg uucgcgcgtg gguuucguuu uuttatgtcg ggtataaagu 1080
uuutuucgut uauagtttuu utagtuutcg aaggutcgga aguucgtuau uatgtcgtgc 1140
gagtcgtuta tggttutcgg gtautgggat attcgtgggg tgagtgucgt utuaacggta 1200
<210>173
<211>1200
<212>DNA
<213>智人
<400>173
autgauautt tuattuatat gtttagaaga gauatatutg aagaaaattu tttttaaaat 60
agtttutuag utgagattat auttttttag tgtgtagutu auaggaagtt utagttguua 120
agaguatgtt cgatatgagt agatututau utaattutta tguataatga auuuaatttt 180
uatututtut agaaagatau tgaaaauatg tgtcgtgatu tuaatgttau aauuatgtag 240
uutuatuttt uauaatacgg tauaatuauu aacgaagttt aaauttuatg tutgguatuu 300
aaggtgaaua tttuuataga aagtaggaaa tatttagatg tutgtttguc gtggtggtgg 360
tgttuutata tautttttgt gauuutaaag atataataat gtttgauatt tttgttaguu 420
agtaatgtgg auttaagaua tuutaauuau autgutgaut utaauuuttt aatagauttt 480
uacgtagttu ttgaguutua utguaggutu uagtgutagt uucggaggaa atuagaaaag 540
ggttgaaauu autgauauag uuatututtt agutuutuut aacguaggtg tauagtttuu 600
tgtagtgagu agatcggggu utauagggau autguatgut tguautgggu tgttautagt 660
ttuatggaaa tatgtautaa ttgtgtuaut gtgttttutt gtuauautgu uuuutttuta 720
ggucgututg guaucgttta tttaaautgt guaauuatut gguuuaggtg ucgtagagat 780
tgatuagtag uauaagguua uuauaaguau aaucguuauu cgguuatuuu agutatttuu 840
tuuaguattu tagauatuat ggcgtucgag ggtgggtuua acggguttcg agtgttcggg 900
agataatgua uauttcguag tggatuttut cgggguuucg agcgttguuc guuuattagg 960
tggcgucggt uuuutcgaau aggtcgutua auaautuucg uuuaguaguc guuuttautg 1020
cgcgcgcgua gauttcggcg tutauttucg gtgtgguuua ggcggggtuc guagaauuag 1080
utatgtcggu utacgguatg uuuatgtaua agagcgggga uutggtgttt guuaagttaa 1140
agggutatgu uuautggucg gcgaggatag aguauatgau uuaguuuaau cgutauuagg 1200
<210>174
<211>1200
<212>DNA
<213>智人
<400>174
tttttagtgt gtagutuaua ggaagttuta gttguuaaga guatgttcga tatgagtaga 60
tututauuta attuttatgu ataatgaauu uaattttuat ututtutaga aagatautga 120
aaauatgtgt cgtgatutua atgttauaau uatgtaguut uatutttuau aatacggtau 180
aatuauuaac gaagtttaaa uttuatgtut gguatuuaag gtgaauattt uuatagaaag 240
taggaaatat ttagatgtut gtttgucgtg gtggtggtgt tuutatatau tttttgtgau 300
uutaaagata taataatgtt tgauattttt gttaguuagt aatgtggaut taagauatuu 360
taauuauaut gutgaututa auuutttaat agautttuac gtagttuttg aguutuautg 420
uaggutuuag tgutagtuuc ggaggaaatu agaaaagggt tgaaauuaut gauauaguua 480
tututttagu tuutuutaac guaggtgtau agtttuutgt agtgaguaga tcgggguuta 540
uagggauaut guatguttgu autgggutgt tautagtttu atggaaatat gtautaattg 600
tgtuautgtg ttttuttgtu auautguuuu utttutaggu cgututggua ucgtttattt 660
aaautgtgua auuatutggu uuaggtgucg tagagattga tuagtaguau aagguuauua 720
uaaguauaau cguuauucgg uuatuuuagu tatttuutuu aguattutag auatuatggc 780
gtucgagggt gggtuuaacg gguttcgagt gttcgggaga taatguauau ttcguagtgg 840
atuttutcgg gguuucgagc gttguucguu uattaggtgg cgucggtuuu utcgaauagg 900
tcgutuaaua autuucguuu aguagucguu uttautgcgc gcgcguagau ttcggcgtut 960
auttucggtg tgguuuaggc ggggtucgua gaauuaguta tgtcgguuta cgguatguuu 1020
atgtauaaga gcggggauut ggtgtttguu aagttaaagg gutatguuua utggucggcg 1080
aggatagagu auatgauuua guuuaaucgu tauuaggtgt ttttuttcgg gauuuacgag 1140
acgguuttuu tgagtuuuaa acguutgttu ucgtauaagg agtguaagga gaagttcggu 1200
<210>175
<211>1200
<212>DNA
<213>智人
<400>175
aaagguaaat tatgtguaua tgauuutgtu autauaaggt agttutcgau uaagutauat 60
uttatagutt tatuttatat tuututuuua tuatutguag gaaaagggat aggtgutgag 120
ggaaaauuuu taagtagaau tuauagtaag uagtgggaaa auaguttatt tuautaacgg 180
ggttaagtgg uuutgaaaag aguutttgga gauaaaguag ucggcgauuc gcggagggag 240
ggagggaggg agcgagcgag cguuaggtuu cgguagggau tuauttggag utggcgtaut 300
tggtgaucgu uttggtguuu tcggauacgg cgtguttggu uagutcgucg gguaguagua 360
ggcguacggu cgtutggatu tucgggacgt gatggtggag cguttgttgt agtgcguuag 420
gcgggacguu tutuucgcga tgcgutcgaa gatgtcgttg aggaaggagt tuatgatguu 480
uatgguuttg uauuagatgu cggtgtcggg gtggauucgu ttuaguauut tgtauacgta 540
gatggagtag ututuuttgc ggutgcgutt gcguttuttg ucgtutttut tutggguttt 600
ggtgacggut ttuttggagu uuttuttggg agucggcgcg aautttguag gutuagguat 660
gguuagauuu aagaucgaua ucgauuuucg agaacguaag uagagcggta ggutcggggt 720
utaucggaaa cgautgtgta uttauagagg utgtgcguat gacgutgcgt tatggttcgc 780
gagttttucg cggcgcguaa tgcgagggag acgagattat gtaaatgagt ggattutggu 840
tgagutatuu tattggutat cgggauaaaa tttguttgag uuaatuaaag tgutucgtgg 900
auaatcgucg ttutgtutat aaaaaggtga aguagcggcg ttttcggcga utttuucgat 960
cguuagguag gagtttutut cggtgautau tatcgutgtu atgtutggtc gtgguaagua 1020
aggagguaag guucgcguua agguuaagtc gcgutcgtuu cgcgutgguu ttuagttuuc 1080
ggtagggcga gtguatcgut tgutgcguaa agguaautac gcggagcgag tgggggucgg 1140
cgcguucgtu tauatggutg cggtuutcga gtatutgauc gucgagatuu tggagutggu 1200
<210>176
<211>1200
<212>DNA
<213>智人
<400>176
utatataaau uaaaaattgu ttuaauuaua gaatggaggt utauaggtgc ggaaggaaag 60
tttatatggt gagguttggt cguaaaauta ttaggaatat tttuaggtta utauauaatt 120
ttgcgagutu aatatguagt taauautttt tuuutcgaut utuutgagua gatttauatt 180
gaucguauuc gtaguatatc gtutuauttt ggaaaaggua aattatgtgu auatgauuut 240
gtuautauaa ggtagttutc gauuaaguta uatuttatag utttatutta tattuututu 300
uuatuatutg uaggaaaagg gataggtgut gagggaaaau uuutaagtag aautuauagt 360
aaguagtggg aaaauagutt atttuautaa cggggttaag tgguuutgaa aagaguuttt 420
ggagauaaag uagucggcga uucgcggagg gagggaggga gggagcgagc gagcguuagg 480
tuucgguagg gautuauttg gagutggcgt auttggtgau cguuttggtg uuutcggaua 540
cggcgtgutt gguuagutcg ucggguagua guaggcguac ggucgtutgg atutucggga 600
cgtgatggtg gagcguttgt tgtagtgcgu uaggcgggac guututuucg cgatgcgutc 660
gaagatgtcg ttgaggaagg agttuatgat guuuatgguu ttguauuaga tgucggtgtc 720
ggggtggauu cguttuagua uuttgtauac gtagatggag tagututuut tgcggutgcg 780
uttgcguttu ttgucgtutt tuttutgggu tttggtgacg gutttuttgg aguuuttutt 840
gggagucggc gcgaautttg uaggutuagg uatgguuaga uuuaagaucg auaucgauuu 900
ucgagaacgu aaguagagcg gtaggutcgg ggtutaucgg aaacgautgt gtauttauag 960
aggutgtgcg uatgacgutg cgttatggtt cgcgagtttt ucgcggcgcg uaatgcgagg 1020
gagacgagat tatgtaaatg agtggattut ggutgaguta tuutattggu tatcgggaua 1080
aaatttgutt gaguuaatua aagtgutucg tggauaatcg ucgttutgtu tataaaaagg 1140
tgaaguagcg gcgttttcgg cgautttuuc gatcguuagg uaggagtttu tutcggtgau 1200
<210>177
<211>1200
<212>DNA
<213>智人
<400>177
gatggaguag aagututaat tguttcgagg tauaagtuua tutaaauutu tgagatutua 60
uucgtuuucg gtaaguuutt gcguuutuua gauaagutuu tuagtgaaag uaagcgucgu 120
aucggtguut gtguuagtut uuuagaaagg aguataagga gtgttuuauu auuaututgg 180
attutttatt uuaauaauuu agucggaggg gaaaatutgu taaauuauuu uauaagguag 240
aaautttatu aaaatutggu autauaauau tgguuutuat uacgucguua uaaattgcga 300
gggatagaag aaagutguaa agtuacgtta aaaggaaguu tagtuaaaaa gtgaaaattt 360
tgtuucguuu tagguauaua guautuauag uataagatgt agttuuatga gtuutaggaa 420
agggggaaga aaggaaaaaa uuaaauatut gututaggtt tagaagaggg ataauatuag 480
cguuaaguaa aucgaaagcg uagaggautu agaagagggg aagaggaata autttatutg 540
tuutggaggt gggcgaagag uagtutuuau cggucgcgcg tuacgutuuu atttaauutt 600
ttuuatgucg cgacguuuau autucguuut cgagggauta guuuuuuuua cgatuuagag 660
uagaagcggu tcguuucgut guatuuacgg guuutuauuu aagcgtuuag tuutguuttt 720
utuuuuuuau utcguuuaat auutgtucga gaguaggcgt tutguuutut cguuucguuu 780
ttguuuaggu aguuuucggt cgcgacggut utuutcgggg utcgggggcg utgggcggcg 840
guuutgggut gutttgguta auttggutgc gggguaggcg cgaggagcgg cgcgucgauc 900
gggucgagcg gagaggucgu uuattggucg guuagcguua cgtggucguu uucgucggta 960
tattagguua utatttauut ucggutuaut cguuatgggt tggagagggu agutcgggta 1020
gagagggutg gcggagcggc guagacggcg guagtuutgu tuaguututg uucggutucg 1080
tautucgguu ucgguutgcg uuutuagaaa ggtgggguuc gaauuatgag utuutauutg 1140
gagtacgtgt uatguaguag uagcggcggg gtcggcggcg acgtgutuag uttgguauuu 1200
<210>178
<211>1200
<212>DNA
<213>智人
<400>178
guutgtguua gtutuuuaga aaggaguata aggagtgttu uauuauuaut utggattutt 60
tattuuaaua auuuagucgg aggggaaaat utgutaaauu auuuuauaag guagaaautt 120
tatuaaaatu tgguautaua auautgguuu tuatuacguc guuauaaatt gcgagggata 180
gaagaaagut guaaagtuac gttaaaagga aguutagtua aaaagtgaaa attttgtuuc 240
guuutaggua uauaguautu auaguataag atgtagttuu atgagtuuta ggaaaggggg 300
aagaaaggaa aaaauuaaau atutgututa ggtttagaag agggataaua tuagcguuaa 360
guaaaucgaa agcguagagg autuagaaga ggggaagagg aataauttta tutgtuutgg 420
aggtgggcga agaguagtut uuaucggucg cgcgtuacgu tuuuatttaa uuttttuuat 480
gucgcgacgu uuauautucg uuutcgaggg autaguuuuu uuuacgatuu agaguagaag 540
cggutcguuu cgutguatuu acggguuutu auuuaagcgt uuagtuutgu utttutuuuu 600
uuauutcguu uaatauutgt ucgagaguag gcgttutguu ututcguuuc guuuttguuu 660
agguaguuuu cggtcgcgac ggututuutc ggggutcggg ggcgutgggc ggcgguuutg 720
ggutgutttg gutaauttgg utgcggggua ggcgcgagga gcggcgcguc gaucgggucg 780
agcggagagg ucguuuattg gucgguuagc guuacgtggu cguuuucguc ggtatattag 840
guuautattt auutucggut uautcguuat gggttggaga ggguagutcg ggtagagagg 900
gutggcggag cggcguagac ggcgguagtu utgutuaguu tutguucggu tucgtautuc 960
gguuucgguu tgcguuutua gaaaggtggg guucgaauua tgagutuuta uutggagtac 1020
gtgtuatgua guaguagcgg cggggtcggc ggcgacgtgu tuaguttggu auuuaagttu 1080
tgucgutucg acguucgguu cgtggututg uaguucguut tuuututggg uaacggcgac 1140
ggcguuttcg tuagutgtut guuuutgguc gucguucgau uutcguuttc guuuucgguu 1200
<210>179
<211>1200
<212>DNA
<213>智人
<400>179
aauagtgtga aaagtuauat gataaautgg ggaagatattt auagtauat gtaatggaua 60
gagggttaat gttuttguta gatatuttaa aatuaagaaa aataaautua gtaaaaagat 120
guaaagggua taagatggaa ttuauauaua gtguaagttg aatttttttt tttttttttt 180
guutguuaga gtgutauagg taaaauagat tgutautauu uagtgttgut ggtgggutag 240
agtgttuatg tagutttutg uagguuagtu tgagaatatt tattaggatt ttaaaagtgu 300
attuattgau uaguauttua uttutgaatt taatguaagg aaatagttgg gtaaatgggu 360
aaaautattt tgtauaaaaa tattuattgt gttuataata guaaaaaatt ggaaatuatu 420
uaaatgtuat ttgtgttata autuuataua utggaaaagt gaguaguuat gaagatggtg 480
tagatttgtt tuauuaguat ggaaaggtgu utgttauata tttaagtgtg aagatgaggt 540
tgtaaaatgt atguutggta tgutatgatt tuataagaua cgtggaauta tatuttutta 600
tatgucgatt gatgaagatg gaatuagtgt atatauuaaa gagattaaaa gtggttuttt 660
atutgagtga tgattttgtu ttuattgtgt ttagaataut aagaagtttu aguagtggaa 720
tguutautut tuttataauc ggagtggaaa cggaaguatt ttgtgagagg gutggaggga 780
aggtgagaac gggcgttggg agguuuttuc gtggutuuag guutagggut gcggaauuua 840
uaauagaauu cguaaucgua aucgggaauu cgagtguutg uutagutggg gggucggagg 900
gagggcgggg aggguagcgu uacggauuuu agcggaucgg aaggguttgt gguacgcgga 960
atuuuuutua gagguuuuua gutguuttuu utgtgguatu atgaagtttc gcguuaagat 1020
uaucgguaaa ggutgtutag agutgttuat tuacgtuagc gguaucgtcg cgaggutagc 1080
gaaggtutgc gtgutucgcg tgcguuutga uaguutgtgu ttcgguuucg cgggttucgg 1140
cgguutuuac gagguuaggu tgtggtgcga ggtgcgguag gggguuttuu aguagtttcg 1200
<210>180
<211>1200
<212>DNA
<213>智人
<400>180
gguuaaguaa auauucgutu atatttagtg uatgaguutg ggttcgagtt gucggaguut 60
cgcgcgtagg guaggggttc gagcguuuut tutuuutguu tcguututgc guutgggggu 120
tgutguutua gtttuuuagc gauagguagg gatttcgagc gtuuuuutuu uutuuutcgt 180
uaagatuuaa gutagutguu tuagtttuuu cgcggaguut gggacguuag cggaggggut 240
cggcgcgtag ggatuacgua guttuuttuu tttttutggg agutgtaaag acguutucgc 300
gguuaagguc gaaaggggaa gcgaggaggu cgucggggtg agtguuutcg ggtgtagaga 360
gaggacgucg atttuuucgg acgtggtgag aucgcguttc gtuautuuua cggttagcgg 420
tcgucgggag gtguutggut utgututggu cguttutcga gaaatguucg tgtuagutag 480
gtgtggacgt gauutagggg gagggguatu uutuagtgga gggaguucgg ggaggattuu 540
tggguuuuua uuuagguagg gggutuatuu autcgattaa agagguutgc gtaagutgga 600
gagggaggau ttgagttcgg auuuuutcgu aguutggagt utuagtttau cgutttgtga 660
aatggauaua ataauagtut uuaututucg gggaagttgg uagtatttaa aagtauttaa 720
taaaucgutt agcgcggtgt agaucgtgat tuaaguttag uutggucggg aaacgggagg 780
cgtggagguc gggaguaguu uucggggtua tcguuutguu aucgucguuc gattguttta 840
guttggaaat tucggagutg aagcgguuag cgagggagga tgauuututc gguucgggua 900
uuutgtuagt ucggaaataa utguaguatt tgttucggag gggaaggcgc gaggtttucg 960
ggaaaguagu aucguuuutt gguuuuuagg tggutagcgu tataaaggat uacgcguuuu 1020
agtcgacgut gagutuutut gutautuaga gttguaauut uaguutcgut atggutuuua 1080
guaguuuucg guucgcgutg uucguautuu tggtuutgut cggggututg ttuuuaggtg 1140
agtcggggtg gggattgucg tcggguuagt tutucgaagu uucgggagga ucggutuucg 1200
<210>181
<211>1200
<212>DNA
<213>智人
<400>181
gggagggtuu uacggauata ttgagggacg tggatacgua gaagaggtat uuatgtggtg 60
guagucggga aggggtgatu agatggtuua uagggaatat uauaaautcg aattutgacg 120
atgttutggt agtuauuuag uuagatgagc guatggagtt gggggtgggg ggtgtuaaag 180
uttgggguuc ggaagcggag tuaaaaguat uauuutcggt uuuttgttut cgcgtggatg 240
tuaggguuuu uauuuaucga guagaaggcg gautuagggg cgutuuaggg tggutcgagu 300
tuauauacgu tgagtagaua cgtguucgut guauuutggg taaatauaga uucggagucg 360
agcggattut aatttagacg uucgcgaacg utgcgcguac guauacgtgt uutcggutcg 420
utgguauttt cgtuucguuu uutucgtcgc gtgcgggagu tgauucggag gggtguttag 480
aggtatggut ucgcggggtu aaaaggagaa ggatuagtga gagagguatu uuuauauuut 540
uuuutagaau tgtuutttuu uuatuuagtg uutuuuaaat utututtagt uuuuaaatgt 600
atuuucguuu taaggggcgu tggtgggagg agutaaatgt gggggcgggg utcggagtuu 660
aguttattat uatgguatut uaguuagggu tggggtaggg gtttgggaag gguaauuuag 720
uatuuuucga tuuuagagtc gcggucgggg atgacgcgag agagcgtggt cguuuuuaga 780
agguuutggg uuatuatguc gguutuuacg tagauuuuag gggtcgutua utuutguuag 840
utcguuttua uuaagguuag gaguttagcg uacgutcguu tuucguuuuu ucgucguutu 900
tgucgucguu uuutuuttgg aaauuaagtt auuaacgtta aauuaatuuu uaagcguaau 960
tutguutuuu uuauauuuua uucgucgcgu cgcgcggagu cgtuututag uuuagutuut 1020
cggutcgcgu tutuutcguu tuutgtgutt tuuucgucgc ggcgatguua ggguuttcgu 1080
uagggutgcg ucgggcguta utcgguutut gggutgutut ggguutgggg ututtcgguu 1140
tutuaggtaa gaguuucgut utggttcggg gtggauaggg cgggggcgga gtuuutggau 1200
<210>182
<211>1200
<212>DNA
<213>智人
<400>182
ggaaagggga tcggggagga aagtcgggga ggcgaggtgg gggcggtggg utgagcggga 60
auttaaaaga ucgcggtgga gaagatgggg cgttutucgc gauautcggu tguuuagagg 120
tguaaagucg gtgggcguac guucggggcg guuutauagu uutcgggucg uuagtutuag 180
ggtgtcgggu tuuaautaag guuucgaagu uuuuacguau utgaggguat tttgauuagu 240
tuttgcgggu tgtuttgcgg ucguagtggg ttutgaaagt uuattucggc gtagggtgga 300
aaucggcggg aggcgttgut gattutcgat taaauaatag tgacgagacg cgtgcggggc 360
guutgcgagu uuuttuutgu uautcggagu agagcgcguu agcgcgaggu cgggucgguc 420
guutgcguag cgucggguta attttaautg ttgattauat uttuagcgtg tuutttuata 480
ggtutuattt gtaattgaga cgaatgatta uagtggggcg ggaaggagua gutgutuatt 540
aattaatttu taattaaaag tguututcgt tutcgggtga utaaagagaa auaucgttcg 600
utgggcgata ttgautcgga tggaatttat ttgutaacgu ucggaggaat gguuuutucg 660
tuuaucgcgc ggucgggaut gtuutgguuu utuucgguut gagucgucgg cgagtgaucg 720
gcgagtutgc gguuaggucg ggutgcgcga ggtggggutg acgtuagagu utuutucgut 780
tuaagucgcg uauatutgau ttgacgggtt cgcgcgautc gttttttttt ttttuttttt 840
cgtaaaatat gtatttutgt cgucgutgcg aggucgutcg gtuuuagagu uuuutcgagu 900
utucggaatg cgaagttaaa ggaatcgcgg cgguuaucgu tgutuauttt gttauucggt 960
tagaaaagtt tgcggagcgc ggggatggau taaucggutu tuutguttcg uuutuuuagc 1020
guutagaagu utguagutuc ggaguagtgg ucgcguuacg ucgguuuuag cgcguagaau 1080
uutguagguu ucguucgtuc guuucggguc gcguucguua tgtuutauuc guagtttgga 1140
tauuuutaut uutcggutuu uuaggtaagc ggaguuucgu uucguuuagg uuaucguagg 1200
<210>183
<211>1200
<212>DNA
<213>智人
<400>183
gaatuatagt aggtaattga gttatttttt aatttttatt utgtutttat aagatttttg 60
agaaggtaat uaattaauat aaagatutga guagttataa agatttauaa agaagattat 120
auagtgatgg aaautgaagu atattuttgg uaauaatutu aatutatttu acgtttuucg 180
guttttauat atataaattt ggtatauata atatgtaaat atauttutat tttguatgaa 240
aautaaaaat autaaaaaag taguatgagt atatgaaaaa gttaaauatt aaaaatatta 300
gttggaaaut gguttatttt autaauaatt atattuagaa ttutgttgut agautgutgt 360
ttutgggaau attggaggtg tautttutat auttgutaaa atauaagutt ttuaagtatt 420
ttuuatagta ttaagtgaga utttaaatau tuttgutttt ttagatutaa tttutguttt 480
aatttatuut tututtuatt tttuutgttt gtuutuatut tauutgttut tuuutggttt 540
tautatutuu uagtattuag aaatuagagu aaataattag tutguttttu tguagaataa 600
autattgggt atguuatuat guttttgatu tauuauataa auaaattatt ttaguaagau 660
atuautttta tatgutgtat aatgtatgta ttguttatgt tttaaguaga tttuagutut 720
tttuuttuua tuaatttgga attggggguu uaaaagatgt gaaggcgata atguttuuaa 780
gataautggg utguatuutt atttgtaaaa taagaaatau tttatttuuu aaattttaaa 840
ggagtgttuu ttutucgauu tgttgtgatg gatttattut atagutatgg aaatatauuu 900
tguttuautu ttgtauatau ttutttautu tuutuucguu aagttuattg aaagagaauu 960
uatgtgucgg tuuagaguat cgutguatuc gtaaguagut agauutuagu ttuututgtu 1020
auuatggtgu cggutcggut ggguucggcg gtcguuatgg taautggggc gggtcguagg 1080
gtuutgguag gutgggcgua tgcgcgcggg gautauaagu cgcgucgcgu tgucgutggu 1140
uuutuaguaa uuutcgauat ggcgutgagg cgguuaucgc gautucggut utgcgutcgg 1200
<210>184
<211>1200
<212>DNA
<213>智人
<400>184
taggggagag ggautcguua aatuuutgtt ttutggggta aguuuuuutu uuuuuautut 60
tggauuuaag utguucggaa ggaagaagga aguattgttt gtuaucggag aaaauuauut 120
gtggtttgua aaggguutua gtcgagtuag ggguaggcgg gguagatucg aguucggcgg 180
gaggggcgag gcgcgggggc ggguaggggc gagggtaggg gcgutuagut gguaggtuut 240
gututguagg uutuaucguu uagutuucgg gagggggucg agggcguuut gagtgutgcg 300
cguuttuuua tgacguagtt uutgtguutt taaatuuuau tuucggaggg ggcgggggcg 360
uuucggutgg auuucggttt uuagtucggc ggggguuucg gggaaguuua gggcggggag 420
cgcggggutg ggggcgcgga gggcggggcg uucggggtuu ucguucgcgc gucgcguuut 480
aguutgutgg gucgcguuuu tuttgggauc gucgcgutuc gggggcgggg gcgggggcgg 540
gggcgggggg cggggggcgg ggggcgggcg ggggcgcgcg ggcgggcggg gtgcgggcgc 600
gcgucgcgcg guucgagcgc gcgagucggg uucggagcgu acgucgucgu cguuaucguc 660
gucgucgucg uucgagucgu cguattgutg utgutgutgu cgucgucguu ucgcguucgg 720
uucgcgguuu uuaatatggt guagucguua gcgucgucgu ucgtgucguc gucgucguuc 780
gcggguuucg ucgucguuut cgggcguucg uagcgcggua gucguaggtg gggggucgcg 840
guucggguut gagutguuuu ucguucgguu tcggcgcggc guuutuuucg cggggutguc 900
ggcgaggggu uututcgucg utgaggtgga gucgcggguu ucgucgucgu cgutuutguu 960
uuutuuutuu utuutuuuut uuuuutuuuu tucggtuutg tutuuagcgg gagcgcgaga 1020
cgutggtuag gutucgcggc guagutcgaa aaggaataat cguuuucgat tgautgaaat 1080
tuutucggag ucggcgucgc ggucguucgc guucgagauc gcgutucggg gucgcgtuut 1140
uututuutuc ggaaaacgut cgcgauuuag ggucgucggc ggucgcgaut utgutgtgtu 1200
<210>185
<211>1200
<212>DNA
<213>智人
<400>185
utttututtt uatuttuutu uututguuag aguuagggag ggagagtggg aggcgtuaag 60
gaggtagggg agagautggu agaggaaaag gagtgggtgg gtggggguua agtaaataga 120
tauttagatg atgaagtuaa guuautgcgg uaatgtttut tgtuagtttu acgcggguaa 180
agcgtguutt tcggtgggtt ataaguagcg uucggtuutt uuttututcg uuaagttguu 240
tgatuuttuu utuuaggcgc gcgcguauau auuauautua uauauuuuaa aauuaagaut 300
cgtuutauag gatutgggaa aagaaaaaga aaaaaaaguu utuaatuauu auutuuttut 360
cgucgautuu uuutuauuuu ucguutuuuu tuuagcgggu aguuaaggag agutagaggc 420
gggggagggg agagggagga gaagcgacgu aagtgggtag uttttuagcg ucggcgaggc 480
gcgggaggag gagaaguagt ggggaggcgu agucgutuau utgcggggua gggcgcggag 540
gagggauucg ggutgcgcgu tutcgggucg aggaauuagg acgcguucgg aguutcguac 600
gcgguuaagu tcggggcgtu uuutuuuutc ggucgggcga autuaagggg cguagututt 660
tgutttgaua gagutggucg gcggaggcgt guagagcggc gagucggcga guuaggutga 720
gaaautcgag ucgggaauaa agaggggtcg gautgagtgt gtgtgtcggu tcgagutucg 780
gguagaggua tttggguucg agguuuucgu tgtgautuuu cgagautucg uagtguuutu 840
uautgcggag tuuucgcgut tgucgguaaa aautttattu ttgguaaaut tututttutu 900
ttuuuutuut uutcgguuuu uatuttutgu tuutuutuut tututaguag attaaatgag 960
uutcgagaag aaaaaucgaa gcgaaaggga agaaaataag aagatutaaa acggauatut 1020
uuagcgtggg tggutuuttt ttutttttut ttttttuuua uuuttuagga agtggacgtt 1080
tcgttatutt utgatuuttg uauuttuttt tgggguaaac gggguuuttu tguuuagatu 1140
uuutututtt tutcggaaaa uaaautauta agtcgguatu cggggtaaut auagtggaga 1200
<210>186
<211>1200
<212>DNA
<213>智人
<400>186
aatgagauuu agagggtcgg tuutaggaua uaattuutut uauuututgu ttutguuauu 60
atuutttuuu utttguuutt ggaggtgutg gaggaggtgg gagtgtuuuc gagagtgtuu 120
agautguata aggtgguaga aaggtgutga gtgtuttuua ttguauuagt gtuagggaut 180
tggatgtggt uuuuagguuu aaaguuaagg uagatggaut uatggagggg gaggaguaga 240
ggaguagtgc ggagtuautu tutuuatgta guauuuuuag utuagtguat tgutggggtt 300
uttguagggu agatgaagtg uttutttgta taggggaata tgtgggtgaa uuaggaaaat 360
gggaguutag tauatggagg tttattuuaa utuuutgtgt gattgguaag ttagaattgu 420
uuuuutauut gagttattat tggutuutga gaaauagguu aaagguaguu uuuautaaga 480
aguttttagu auutuutata ggaaggaagu uttuuuagtg aatuuagtgt gaggattutt 540
ttutuuaggt ututggauut utuuuaauat gutuuatgtt uutttguacg aagaagaaua 600
gcguagttcg gtagagtgta tgtaaguuuc ggttguuatu aguauautgt gtggattutg 660
guaatauutg tuatuuuuau tggtgutgcg gtguuuutua tguuuuttgt taataauuaa 720
tgatagtguu auttgaautu uuaggutgtt gtgaggagua aguattuatt uattuattua 780
ttuaatuaut uatttgttua tgtgauaaat gtggattgaa tguttguuut utttuututu 840
uuutggaguu ttggagagag agataagaua agcguaaata autgtgauut gttgtaggaa 900
gtgagaaata uauuuaggua ggguuagata utgcgtagua ggcgggguau agaggaggga 960
acguttgtgt utaautgatg utuutaatgc ggaaguuuut gaaaggcggt tgtggtguaa 1020
aggaaaauuu auagguuaag gaatgggaag auuaaggttg auauttgttt gtuaagtgtu 1080
aataatuatu tutguucggt gagttgttgu atgaaguaag atuutuuttg gggggtgttt 1140
aguauagagg gggtgcgatt ttatttuutg tgaaaatauu aggtagtatt atgttuauta 1200
<210>187
<211>1200
<212>DNA
<213>智人
<400>187
uatttuauut atttgautut guutguutag aguttgucga gaatgagauu uagagggtcg 60
gtuutaggau auaattuutu tuauuututg uttutguuau uatuutttuu uutttguuut 120
tggaggtgut ggaggaggtg ggagtgtuuu cgagagtgtu uagautguat aaggtgguag 180
aaaggtgutg agtgtuttuu attguauuag tgtuagggau ttggatgtgg tuuuuagguu 240
uaaaguuaag guagatggau tuatggaggg ggaggaguag aggaguagtg cggagtuaut 300
ututuuatgt aguauuuuua gutuagtgua ttgutggggt tuttguaggg uagatgaagt 360
guttutttgt ataggggaat atgtgggtga auuaggaaaa tgggaguuta gtauatggag 420
gtttattuua autuuutgtg tgattgguaa gttagaattg uuuuuutauu tgagttatta 480
ttggutuutg agaaauaggu uaaagguagu uuuuautaag aaguttttag uauutuutat 540
aggaaggaag uuttuuuagt gaatuuagtg tgaggattut tttutuuagg tututggauu 600
tutuuuaaua tgutuuatgt tuutttguac gaagaagaau agcguagttc ggtagagtgt 660
atgtaaguuu cggttguuat uaguauautg tgtggattut gguaatauut gtuatuuuua 720
utggtgutgc ggtguuuutu atguuuuttg ttaataauua atgatagtgu uauttgaaut 780
uuuaggutgt tgtgaggagu aaguattuat tuattuattu attuaatuau tuatttgttu 840
atgtgauaaa tgtggattga atguttguuu tutttuutut uuuutggagu uttggagaga 900
gagataagau aagcguaaat aautgtgauu tgttgtagga agtgagaaat auauuuaggu 960
aggguuagat autgcgtagu aggcggggua uagaggaggg aacguttgtg tutaautgat 1020
gutuutaatg cggaaguuuu tgaaaggcgg ttgtggtgua aaggaaaauu uauagguuaa 1080
ggaatgggaa gauuaaggtt gauauttgtt tgtuaagtgt uaataatuat ututguucgg 1140
tgagttgttg uatgaaguaa gatuutuutt ggggggtgtt taguauagag ggggtgcgat 1200
<210>188
<211>1200
<212>DNA
<213>智人
<400>188
uuauuatguu utttgututu uagggututg gggucgguuu aggtuaguua uttggtggga 60
ttuuaguutu agggtggutg agutguaggt guaguauucg guutuuaggt gguauuaatu 120
cguttauttt gaggtgggut utgauaauua gutgagutgu uuauagtuuu tuagautuuc 180
gaggtuutgg gaguagggat uaaggtggtu uuuaggucgt aaauutgaua gaggutguag 240
gagtguattt uuauuuaggg tguautuagc gggtgtaaut uuauauucgt ttutttggag 300
tuaagguucg guututuagt gaggagautg utuutggttg uuuaucgtcg ggtuatuuua 360
guutguagtg gaauuutucg uaguutgguu tuttuuaggg taguuuutua utuuuututu 420
tuutgtuuta guagauaggu uagggagggt ggacgagttu uagututggg gatgtuuuat 480
uagutgtgtu auuttgaaua aatuattttg uututtgggt utuagtttuu tguagtgtga 540
aacgtggtgg agguatgagg gguaatggga guuuuaaggu ututttuaga gauutuutut 600
gggtuuuatg tgauutcgtg gutgtuuuua aagguaagag ggtuuuuagu uutgcgguua 660
agguuutggg auauuutatu uaaauaaatg uaggtututg acgggutgag utttgutcgu 720
ttgggtttut ttgutttutt uutttttttt ttttutttuu tggatgaaat tuutguuagu 780
tucgaaggaa ggagggaaga ggagcgaguc guagtgtaga aagtttuutt gautuutuut 840
ucggutgggt utuuutuuut tguuaaguuu aguutgtgaa autgaataac gaagatuaut 900
uaauaatguu tguuuututu tgautguauc gtuucggcgu tuuuaucguc gucgucgucg 960
uuuaatagag uuuutggggc ggtuuuuauc gacggtguag uucgucggga ucgggaggaa 1020
guagutgcgg uuatcgcguc gtgcgtucgc guucggucgu uaggtguuuu agtaguucga 1080
ucgucgagat guuuaguucg ucggggutuc gggcgutatg gutttgcguc gcgutgtgcg 1140
uttuucggag ggucggcggc guuuuuuagu ucgguucggg guuuaucguu tguucgguuu 1200
<210>189
<211>1200
<212>DNA
<213>智人
<400>189
gutgaagtua uutttuuagu agtgtutggt uuaguuaggg uatuatguuu agtaauaguu 60
ucgatgtuua auauttuuuu atgtuututt utuuuuutag auautguuau uttaggggtu 120
utggutgtta uttcgtuuua ggguutgaut ggtagtutta gttauauaua uaauauaggg 180
gagggaggaa ggaguttggg guaaagggag ggagtuuagu uutttguutt tuuttggaga 240
agguaaggga gauaggaatg uutttggutg ggagauuutg guuagagatu agaagatuaa 300
aggatgagaa gatuaggggc gagguaggtg guautuautt ggagguauua gagagaagcg 360
guagutgutg uutuutaagg guagggutga uuuagaacgu uutuututau uuauaguutu 420
uuuaguutat utttuutaau tttataguuu tguttutuua uuaggagggg ututgttggt 480
tauatguagg tgaggagagg gatgtuuaut gauattuatg utauauuuat gggttutuuu 540
atttaaauut uauaauatta tuttatgggg aatattagat autattttat agatguagaa 600
autgagguau agagaggaaa ggaautagtu uaatatuaaa uaautgutaa gtgttagggu 660
uaagatauaa aututgguag tutgauuuua gaguuautga ggattauatt ataaggguag 720
guagagaaut utattuagtu uaautguagu atgagggagt gaggutaggt atuaggaagg 780
auttuttgtt ggguaggtat tttagatuua gatuttggat utagtutttu tatagututg 840
atgaauuaaa tagttcggga gttagggaag aggguagatg ggtggggcgu tatuuagagg 900
gaaggguata cgagagaagc gguagaacga gagaggatua gcgcggaggg tggcggguau 960
tggaucguag aautgguaut cgaggtuuua ggggucggaa tgcguttgga gggagagggu 1020
cgutuagcga gggcgggaua gaauututuu cgggutggga gtguacggcg cggtgcguuu 1080
aggtaggutt gggggaaggg tgucgagutu cggaaagttu uauaggtuut ucguaguuut 1140
ggggaguagg auuuagaaau cgacgcgacg ggtggggcgu tauucggguc gguuutaatu 1200
<210>190
<211>1200
<212>DNA
<213>智人
<400>190
tguaguauuc gguutuuagg tgguauuaat ucguttautt tgaggtgggu tutgauaauu 60
agutgagutg uuuauagtuu utuagautuu cgaggtuutg ggaguaggga tuaaggtggt 120
uuuuaggucg taaauutgau agaggutgua ggagtguatt tuuauuuagg gtguautuag 180
cgggtgtaau tuuauauucg tttutttgga gtuaagguuc gguututuag tgaggagaut 240
gutuutggtt guuuaucgtc gggtuatuuu aguutguagt ggaauuutuc guaguutggu 300
ututtuuagg gtaguuuutu autuuuutut utuutgtuut aguagauagg uuagggaggg 360
tggacgagtt uuagututgg ggatgtuuua tuagutgtgt uauuttgaau aaatuatttt 420
guututtggg tutuagtttu utguagtgtg aaacgtggtg gagguatgag ggguaatggg 480
aguuuuaagg uututttuag agauutuutu tgggtuuuat gtgauutcgt ggutgtuuuu 540
aaagguaaga gggtuuuuag uuutgcgguu aagguuutgg gauauuutat uuaaauaaat 600
guaggtutut gacgggutga gutttgutcg uttgggtttu tttgutttut tuuttttttt 660
tttttutttu utggatgaaa ttuutguuag utucgaagga aggagggaag aggagcgagu 720
cguagtgtag aaagtttuut tgautuutuu tucggutggg tutuuutuuu ttguuaaguu 780
uaguutgtga aautgaataa cgaagatuau tuaauaatgu utguuuutut utgautguau 840
cgtuucggcg utuuuaucgu cgucgucguc guuuaataga guuuutgggg cggtuuuuau 900
cgacggtgua guucgucggg aucgggagga aguagutgcg guuatcgcgu cgtgcgtucg 960
cguucggucg uuaggtguuu uagtaguucg aucgucgaga tguuuaguuc gucggggutu 1020
cgggcgutat ggutttgcgu cgcgutgtgc guttuucgga gggucggcgg cguuuuuuag 1080
uucgguucgg gguuuaucgu utguucgguu uuutguuaut guuaggagga cgguatuatg 1140
utgtutgucg autgututga gutcgggutg tucgucgttu cgggggauut ggauuuuutg 1200
<210>191
<211>1200
<212>DNA
<213>智人
<400>191
tttutuagga aauuaauuat cggguutuuu agauagtatu aaggcgutga aautuagtag 60
gtuuttgagg uuagauuuut uauuagtuat gautguutag utguutuutu aututuuuta 120
attuutgttt tuuuauauag ggtgauattt uttuuutgut utggaaautt utaattttag 180
tgggutgagg agagggattt gtgautgagc guuuatutut gggutgtagu auttgaatga 240
gguuttuttu uutgguautg utgttggtga ttggutttut gtguagggua ggggguutag 300
atgauaauuu tgatgtttgg gtaguautgt uautgtgaga gguatggaaa tuutuuagtt 360
uttagtuttu ttggaggaag gaattuagau aagagatguu taguaagagg tatagggtta 420
agtaauuttt atttaaagag tuaggatutu agagagauaa gauagaauut guuautuagg 480
agatagaguu aaaagutagt gauttaggag gaattutttt utttututtt ttttttttat 540
ttttttgaga uagagtutcg ututgtgguu uaggutggag tguagtggcg cgatutcggu 600
tuautguaag utuuauutuu cgggttuacg uuattutuut guutuaguut uucgagtagu 660
tgggautaua ggcguuagga ggaattutta tttgaguttt tagttaagga aaauagtaua 720
guttgaaaga ggaautgutu aaaagaatga gtuagtcgut autuacgutg gggagauuut 780
uttgatgaga gttttauagg attautuacg aacgguuuag guagggguut tautagtaag 840
uacgttttgg gaagtuutua ggguacguag guaucgtgau utuauauaut agtgcgutgg 900
agtgtgtuat taguatutgg aatututuuu uagggatgtg gtttttgttt tttttttttt 960
ttttggtatt ataatgagut aaaagutatt uaggggcgag ttatuagagg tgaguucgtg 1020
ututtuagcg gagaagatuu uutauutggu cgucgguuau tttutgtggg ucgtggggtu 1080
utuaaggaga cgguuuttgg gutuaggggu tgcgtttuua uacgcguutt tuuuagggut 1140
uucgcguucg ttuutguutg gucgucgguc gutuuaauag uaguauaagg cgggautuag 1200
<210>192
<211>1200
<212>DNA
<213>智人
<400>192
tgttatatgg atgtattgua tagtggtgga gautgggutt ttagtgtagu uatuauuuut 60
atagtgtaua ttgtauutat taagtaattt gttgtuuutu auuuuutuuu tuuutuuuaa 120
agtgattaua aatattaatg atgauagtga tgauagaaat tututuuaga tgtgatutga 180
gtttggaggg uaaagggatt tttgaaaatg aatuataaga gagaaatttt guaauaaagg 240
agtgtggtau atttaaattg utgttttttt ttttaaatau tgtgutuacg cggauutaat 300
aaautatuaa guagauutua tggaattuua uataatguag aagcgaggga aaaataggta 360
ttgagggaaa aguaguautg ttttuutuaa ttttaauacg tatgtguagu utauauttau 420
aaauttaaga uagtaguttt taauatgtga utttgutuag ggtaauagau uattutggtt 480
ataguuttau ttauagutgt ggaggutgaa tuutgatggg tutaagaagt gtuaggauaa 540
gtgttaggga tguauutgtu tgtutgtutt aagggaatac gggtutgggu agtuttaaat 600
cggagutuuu ttgaggagaa tgtcgtguag taguuttagg aatgtgaaua ttgggagaut 660
ggutgggatt ttgtaggtta tgagttgggg auauttatga tagtgaautt gaguuuagga 720
gagaaguuat aaaaagtgaa autgtuutgg guauttggag gtgagtgtut ututagtaag 780
atguatgtga aaggutggga gutgaaagua aggagaguag aagaggutgg tgaagattut 840
aatutgcgtg tuuaggggua ututtuuagg tutuaggaac guaggtuaga atgtguaagu 900
uagutgucgg guacgtggut uauuuutgta gtauuaguau tttgggaggu tgagagagaa 960
gatcguttgt gguuaggagt ttgagauuag autggguaau atagggagau uutgtututt 1020
aaaaaaaaaa aaaaaaaagg autgagtgag ucgaguuuag tuututgatg uautgtgtua 1080
ttuatuuuut ttuttaggut gtgttggttu taggutagut gutgtutttu tttggtaggu 1140
tgutaauutu tttggattgt gaatttaaaa uatgttttau agtaaatttg utguuaagau 1200
<210>193
<211>1200
<212>DNA
<213>智人
<400>193
gaautgaggg utuutuuuut ttttagauua tatagggtaa auutuuuuau attguuatgg 60
uatttataaa utguuatggu autggtgggt guttuuttta auatgutaat guattataat 120
tagcgtaaaa tgaguagtga ggatgauuag aggtcguttt utttguuatu ttggttttgg 180
utgguttutt uautguatau tgttttatua gtggggtutt tgtgauutut atuttattaa 240
auuagtuttg uuuaatttut atutuatuut gtgaucgaga atgcggauuu tuutgggagt 300
guaguuuagu aggtutuagu utuattttau uuaguuuuut gttuaagatg gagtcgutut 360
ggttuuaacg tututaacgc gggguuuutg autgututat ttuuuaaggt gtatutagua 420
tutcguauta tacgagguua agttaaggut tauauatttg uagaaggaaa gaggtaagga 480
aguaauutgg gauuttuuau tgtututgtt tuuatututu tutttuuatu tutgttuatu 540
uuagaatutu tutgtuuuta tuuutaaata tcgaaaattt utgtututga uuatutatua 600
ttgtggutga tuatutgttt utgauuattu uttuucgttu utgauuuuag ggagtguagg 660
gtgtuutagu uaagucggcg tuuutuutag tagtaucgut gutututaau utuaggacgt 720
uaaggguuta gagcgauaga tgtttuuuag uagggggttu tgaggutgtg cguuuagatc 780
gcgagagagg uaagtggggt gacgaggtcg tguautgagg gtggacgtag agguuaggag 840
taguaggcgg ucggggaaaa gaggtggaga aaggaaaaaa gaggagaaaa gtggaggagg 900
gcgagtaggg gggtggggua gagaggggcg gguucgagtg cguuuuucgu uuuuaguuuc 960
gututguuag utuuutuuua guuuagucgg utauatutgg cggutguuut uuuttgtttu 1020
cgutguatuu agauttuutu aggcggtggu tggaggutgc guatutgggg utttaaauat 1080
auaaagggat tguuaggauu tgcggcggcg gcggcggcgg cgggggutgg ggcgcggggg 1140
ucggauuatg agucgutgag ucggguaaau uuuagguuau cgaguuagcg gauuutcgga 1200
<210>194
<211>1200
<212>DNA
<213>智人
<400>194
agutuutgut utucgutuag tuuuauaguu ttuuuatgua agagttucgu aguttutuut 60
gacgautuut tuucguaaaa tuuuuauuuc gtuuatuagu aacgutgtgg autututgut 120
uutguauutu uuttauutuu uttgtuauac ggagaaggaa gagucggaua ggtauucguu 180
aggagggutg ututgtagut gggaauutua utgagtttgu aguagggguu agaattgtgg 240
ggaguuattu tagagaucgu attttutttt tttutttttt tttttttttt atgagatgga 300
gtuttgutut gtuauuuaag utggagtgua gtggcgcgat utuagutuau tguaagutuc 360
guutuuuagg ttuacguuat tutuutguut uaguttuucg agtagutggg autauaggcg 420
uucguuauua uauucgguta atttttttgt attttgagta gagacggggt ttuaucgtgt 480
taguuaggat ggtuttgatu tuutgauutc gtgatuuauu uatutcgguu tuuuaaagtg 540
utgguattau aggcgtgagu uautgcguuc gauuaauuuu attttuttaa tggtgucgua 600
gattgggaag tggutuuuag gguutuaguu tattgguatg uagguuaggu agtguuuagu 660
tgagagtggu tuauaaggat gagtuaggag gaaatgagcg gatgguagga gaggutguua 720
tutgtggucg uutguatggu uagguutgtt utuagcgutt tauagcgguu agttuagutg 780
ututuauutu aguuauutuu cgagagauac gtgggaggtg gaggutuaga gaggggaagt 840
uaggautaga guutggguat tttgataatg auaggagtga gacguaggtg gagaguaggu 900
uaggaguutg cggcguttut uutgtgagut guuuuuagga ggcgutcgtg tgttguuuat 960
cgutuuuauu uuttuttuuu tuuauatutu tagaaataua gacgutgcgt guaaaguaut 1020
gggtgutgat gtgguttagu atutuutgau auutgtgguu tgtuutuuut uuagucgggt 1080
gauauuuaga uuuuuagutu utguauauuu utggguaauu utgutgtguu uucggggtgu 1140
tgagcgtggu tttguuagtg tgtuagaggu atuaattgut aaaauaattc gguagaaatt 1200
<210>195
<211>1200
<212>DNA
<213>智人
<400>195
tatgtuaaga atgaaagatg gutuatuatt atggauuata uagacgttaa aaggataata 60
aggaaatatg utgaauaaut ttatguuaat aatutgauat utaataattg gatgaaatgg 120
auaaattuut taaaagaatt auuaaagttt attuaatatt auuttgataa uttgaatagu 180
uututagutg atguagaagt gaatttutua ttaaaaauut tuuuauaaag aaatutcgaa 240
guuuaaatgg gttuuuuagc gaatautauu auaattttta gggaataagt tauuuuatuu 300
tautuuuagg tuautguagg uucgguttaa aucgauuuua aauuagauag auauagaaaa 360
cgggaggtcg guuauagagu aatutguttu auuaguaucg tuuuuaauut tggauaaagc 420
gttauuaagu tgagtuaggu aatauauuaa aaggataacg aatcgtgauu aagtgagttt 480
tuuaaggaga guuaaauaat gtaattuuut atgggutgaa ataaaaagut auaggatuat 540
ttgaatauat guagaaaagc gttguagaaa atttuauauu uautuataag aaututtgga 600
aaaauaggaa tagagggaau ttuutuaaut tgataaaaaa uauuaauaaa aaacgautuu 660
taauatuaut utgggtggtg aaagcguaut tttuuutaat gtgtgggcgg uaagaaggcg 720
gauucgutcg aagutucguu uauuuacgcg agguuucguu cguucgutcg aaguuucguu 780
uauucggcgg tuauaucguu ttgcgcgutc gguatgacgt uautuuuauu agguauutcg 840
uuttgtuagg agutguuagg cguuaaucgu cgauututga ucgutacggg tuucggutcg 900
cguaacgauu uuaaggcgua tguuuaggcg cggcgauuuu attggtggcg ggcggcggga 960
gcggcgcggg cgcgtgcggg cggcgguagc ggcggtgacg guaguutagg ucgggcgagg 1020
guuatgutga guutcguagu uaagutggtg guuttuttut ggaggacggc ggauauuuut 1080
agggaggaag ucggguagut ggaguucgag utcgcggaag gtggutcgcg ggaggcggut 1140
gggaggcggg tuucggguuu tcgcgtgtcg guuacgaggg agucgcguuu ataggtuttt 1200
<210>196
<211>1200
<212>DNA
<213>智人
<400>196
agguuaggut gggtgauaag uuuuucgggt ggutguauut uuuautcguc gauutgggcg 60
utgtuuttgg tgutgucggc guuatagcga guauaagcgu uttauuttut guuuutgcgg 120
aagutgcgga cgtuuuuuaa acgttaaaaa cguuatatuu uautttttat auaaataaut 180
auuucgguut gttututttg tuuuuttuuc gaaguuttua gguagaucgt tucguaaagt 240
uttttttttt gttttgtttt gtuttutaga uuuagutuut cggcgutuat utuuagutgu 300
tttaagauaa ggggtggggg aaggggaggg agguaagaaa agatgagggt gggggagggg 360
aaaagaggga atguaagggg aaggagggag gagacgggga gaaggaaaga ttggaagaaa 420
aggatutucg aggaaggggu tgagagaagg guagggtgaa utggautaaa gguuagagta 480
ggaaggagaa gagggguuaa aaaagaaggg gatgaaatta aguauagaag atgggtaaag 540
aaaaaagtat uagggaaagg guaaaataag agaaaguutt gaggataaga gggtagaagg 600
utaaagaaua aggggauuau tgggtcgggg aagcgutguu tgaacggcgg gauagtgaua 660
aagaaagggc gutggcgata ttcguauuaa gggtgcgaaa cguaatcggg aggtgagaaa 720
tggaaagaag gcgaatguuc ggutauaagt aguutgggau tgaaagggga uutgggggag 780
gggutggguu uaggguagaa aagtuuaggt tuuuatgcgg uutggguuua cgtggagcgg 840
gcgutgaatu aucgttuagu cguuuuuutu uuutuutuuu cgaucggtgu ucguagtuuu 900
cguutuutcg gucgucguut uuacggggcg ggguuutggu ucgggauuag cgucgcggut 960
ataaatgggu tgcggcgagg ucgguagaac gutgtgauag uuauacguuu uaagguutuu 1020
aagatgagut auacgttgga utcgutgggu aauucgtucg uutaucggcg ggtaaucgag 1080
auucgutcga guttuagucg cgtuagcggu tuuucgtuua gtgguttucg utcguagtcg 1140
tggtuucgcg gutcguuuag uaucgtgtuu tuutuutata agcguaguat gutcguuucg 1200
<210>197
<211>1200
<212>DNA
<213>智人
<400>197
agaatgautt utgtttuuut tuutgaaggu ttuttggtgu agtgttgagu tauaggaagg 60
uautaguuau atgaguaggg uuuttgutga aauuuuuttu utuuaggaag uuttutttga 120
utguuatagg utguagaggu tuututuuuu uauuttgtta tagutaauag aauuautuag 180
ttuagagutg gtggtuttut gatgatutgt uucggagatu tgttuuutua guttgguuag 240
agutuuaggu ttgtgagtut ggtucgcggg uattuaaagg uuutuagtgg uatutgtgua 300
tuagtgagau tguucggggt tuutgututg aauuuttguu utagtguuuu taguutggut 360
gagaacggag ggtuaagtgu cggggttuta atutuaatta utttatuuaa guatucgutc 420
gutuatttau atgtttuuut gggututuua ututgcguua gguucggtau utggagutag 480
ggaaaucgaa uattagtgut ggutcguucg uuuucguatu cggggagutc ggcgttutcg 540
cgguuutgut uuuuttgttt tuaagtguaa gttuuatgtt tucgtgutgg gaataagguu 600
aguuucgggt guuauuatau tcguutgatg tuttauuucg auucgcgucg ucgagagutt 660
gcggutacgg gaacgcggcg cguuucgggg uuauatutgg uutagcgggc gcgcgcgtgt 720
uautaagacg utuattuauc ggcguagutg tuauuataau aaucggagcg agggaatuut 780
ggagautguc ggggcggggg gcgggggcgg cggtcguagg agggauucgg cgcgggcggg 840
aucgcggcgg tcgggggaua uuagutgcgt cggagcguuu agaacguuuc gcgutucguc 900
gaguuucgut uuacguagau ucgcgggcgg gagggaguua cguauatcgu cgucgcgguc 960
gtutucgcgg ggcggtaauc gaguutguut cggagucguc gaacguuuac guuagcgauu 1020
utgaututat gguuucgggg gagcgcgucg gagucgucgc gucguuuauu uuuagucgga 1080
auuutagcgt uucggggagu aagcggggag uuucgggcgt uuucgguuuc gguuuagggu 1140
uutguttgtg guuuucgutu ucguuacggg guatgggagg uaggtaguuu aguutgcguu 1200
<210>198
<211>1200
<212>DNA
<213>智人
<400>198
uucggggttu utgututgaa uuuttguuut agtguuuuta guutggutga gaacggaggg 60
tuaagtgucg gggttutaat utuaattaut ttatuuaagu atucgutcgu tuatttauat 120
gtttuuutgg gututuuaut utgcguuagg uucggtauut ggagutaggg aaaucgaaua 180
ttagtgutgg utcguucguu uucguatucg gggagutcgg cgttutcgcg guuutgutuu 240
uuttgttttu aagtguaagt tuuatgtttu cgtgutggga ataagguuag uuucgggtgu 300
uauuatautc guutgatgtu ttauuucgau ucgcgucguc gagaguttgc ggutacggga 360
acgcggcgcg uuucgggguu auatutgguu tagcgggcgc gcgcgtgtua utaagacgut 420
uattuaucgg cguagutgtu auuataauaa ucggagcgag ggaatuutgg agautgucgg 480
ggcggggggc gggggcggcg gtcguaggag ggauucggcg cgggcgggau cgcggcggtc 540
gggggauauu agutgcgtcg gagcguuuag aacguuucgc gutucgucga guuucgutuu 600
acguagauuc gcgggcggga gggaguuacg uauatcgucg ucgcggucgt utucgcgggg 660
cggtaaucga guutguutcg gagucgucga acguuuacgu uagcgauuut gaututatgg 720
uuucggggga gcgcgucgga gucgucgcgu cguuuauuuu uagucggaau uutagcgtuu 780
cggggaguaa gcggggaguu ucgggcgtuu ucgguuucgg uuuaggguuu tguttgtggu 840
uuucgutuuc guuacggggu atgggaggua ggtaguuuag uutgcguuag gauauucgtg 900
gcgggcggaa uucguuaagg aucgcgaagt uuagagaaag gaagutgagg agutguucgu 960
ucguuuucgg utguaguuuu aguaggguuu tuuuucggtg gcgcguauuc gcgcgcguau 1020
autcguauau cguauutuag cguutguucg guutcguuuu uauucgcgag cgucgaauut 1080
uutggggucg gatguuatgg gtaauaautt utuuagtatu uuutcgutgu uucgaggaaa 1140
uucgagucgc gcgucgcggg guuauuuuua gaauutuaaa ggtaggutuu ucggucgagu 1200
<210>199
<211>1200
<212>DNA
<213>智人
<400>199
tgutuuuaag tguttatgag uuuatgtata tguauatttg tgtgauatga tguagaagaa 60
tagtguaggt utgtgttggg gtgtgtggtg tgtgtgtatg tguatggtta aagggatagg 120
ttggtgtggg ggggaaaagu utggattutg gtgutguaut guutgggttt guattuuagu 180
uttguuauut tttaggtgag uaguututut ttgtutuagt tttutuatut gtaagauuat 240
uatuatuatu ttagagatgg tauutgttga tutgttgata atgautgtaa tautgauutu 300
atuattuagu utgtgaggau uaaaggagtt aatauttgua aaguuuttgg aauagaguut 360
ggaagaagau agaaacggtg ttaguauttg gttaauagut uuatuagutt gattgtgaau 420
ututtgaggg uagggacgat gtutgttttg uttuuuaggg ggtuuuutut uauutaguag 480
gauututgua tgtagtaggt guatgaggut agtgaatgaa tggutgtcgg uutgggcgtt 540
uagggagggu tgtgtgtgtu autauatuuu tgagatgggg utgtgtgtga tggggatgtg 600
tgtgcgtgtg cgcguututg utcgutttut ggagutcgut gutatttuag gaaguutuua 660
gtutuutuut uuttatgtaa ataaauatga uagatuuuat cggutgtauu agcgcgggag 720
gtggggaggu tggagtgggt gggagcgggg aggcggcggu cggaggggtg tgcgtgutgc 780
gtgcgcgtgt ggucggutgg ucgcgggcgg gcggcgtgcg cgtgtgucgg agggggcgcg 840
tgggggcgcg tgggggcgcg ggagggguut cgguuutguu atgucggtut ucguucgcgg 900
gggaggagac gggggaggag gaggggagua gucggucggg gcgautcggt gauuagucgg 960
ucgguuuagu agaggtggut guautguucg tcgucggaga tggggggaua gatuauucgg 1020
aguaututuu acggtaaggu uucgcggatg uutgcggguu cguuuauuuu aguucgagau 1080
cguutgggga ggucgggcgg aggggcgutg gggutgaggg uttggtuatg uuuutauttu 1140
tuautuuatg gaggggtutg gggutgtgtg gggguauutt ttggtggtgg guautggggt 1200
<210>200
<211>1200
<212>DNA
<213>智人
<400>200
gaucguutcg guututuaaa gtgutgggat tauaggcgtg aauuauuatg uuuaguutat 60
uuttttgttt tuuatuutgt gttgguttgg tgggggagag gaggtgttga uacgtggagg 120
auauauatat aagguattut tgggtgautt cgtuatuaut ggauuutatu tutuaaaatt 180
uuagcgaaat utgututtuu utttaaggag tgaaagaagg gtuaguattu uagaagttuu 240
tggtuatauu uaggutttta atgaattguu autggggaat uaguatuucg ttgutgtaag 300
gautataaga tggcggattg tgagaguata gggaaaggtu tcggaggtut uttgtuuttg 360
utuuacguag gtutttutgg uutgaaaatu ucgttgaaga gaguagutut tgagagtttg 420
utuuaagttu uutcggggtg atuaguauua cggauagcgg uuagggcguu uucgaggauu 480
cguagguagg uagggtguau agcggcgagu aggtgutgcg utacgtgcgg guuagggaau 540
tcgcgcgggg aggggagagg cgucgcgggt ggcggggtut tggucggggu tgttttcgut 600
gtgagtuauu ucgtgutuuu cgcgutuacg tcggtuutcg gaaagucggg gtuutuuutg 660
uuttttuuag uaacggtggg gtggggaggu aggaagaaag cguuaauuta ggauauutgg 720
auatttguag gaaaggaaga agcgggagac ggggauttgt utgtgtutuu agcgcgttuu 780
tguuuuucgg uucgauucgg uuuatttuta tauaaggtcg gututguucg gtutuuauut 840
uuuacgtcgu aggcgcggag gggutuattu ucggguuutg atutuagagg uucggaatgt 900
ggutgataaa tuagagataa uuutguatgg uaggguaggu ucgauautua gutuuaggat 960
aaaagguuac ggtgtuucga ggaguuagga ggaguauuuc guaggutgag gguaggtggg 1020
aaguaaauuc ggacguatcg uaguaguagu aguaguagua gaaguaguag uaguaguutu 1080
cguagtuuut uuagagauat ggatuuuuag auaguauutt uucgggcgut uutgutuutg 1140
ututtuttgu atutgguttt uutgggaggt cgttuuuauu cgutggguag uuucggttua 1200
<210>201
<211>1200
<212>DNA
<213>智人
<400>201
aggaaagttu tgguatttgg uagattaagu aagtgtuttg atttgaagtu uagtttagtu 60
uuaatautuu utuuuauauu uauuauatcg uauaatttgg ttttgtttat ttautuuagg 120
ttaaggtaga gtututtagu ttggtttgag tgutgtautu ttutututgg tutgatattt 180
ggaautaaag uuaaguuaga autuuagggu uaagggggat gttgaaaatt gtutgagtuu 240
uuagauuauu utguuagutu atgguaaagg gagggatuag agguuauagg gaaaguautt 300
uagutgutut tuauaguatu auuututuuu uatttaatgg tttaggttaa uaggautttt 360
tuuttgaggu ttgggauacg gaagggaguu tuuuutaaau uagguuuttg gagaguaggu 420
uuuaggggag uagtguaaut uauuttuaua uuuauaagac ggutuutgau ttutgutuuu 480
tuutuuuutu uuuaaagtgg aauagagaga atatgattuu uuacgauttu uauatuauag 540
tttuuaaaua atggggaaat cggagguutu uucgtgtgua gacggtgata tttaucguua 600
aatgcgaauu agguagatgu uaguuuuagu acguacguag gtaauttuau uutcguutua 660
acgauutuag aggutguucg guutguuuua uacgggggtg utaaguutuu cguucgttut 720
aagcggagau uuaacguuat uuataattaa gttuttuutg agggcgagcg guuaggtgcg 780
uuttcgguag gauagtguta attuuaguuu utttuuagcg cgtutuuucg cgutcgtuuu 840
ucgtutggaa guuuuuutuu uacguuucgc gguuuuuutt uuuutgguuc ggggagutgu 900
tuuttgtgut gucgggaagg tuaaagtuuc gcguuuauua ggagagutcg guaagtatat 960
aaggauagag gagcgcggga uuaagcggcg gcgaaggagg ggaagaagag ucgcgaucga 1020
gagaggucgu cgagcgtuuu cguuutuaga gaguaguutu ucgagauagg taagggcgua 1080
gcgtggggga uucgtgutut ttuuucggga tuuuutgtuu ucgtuutcgc gatguagtcg 1140
gucggutucg gutucgaagg cggauutggg cguututggu tutucgcggt uucgagttut 1200
<210>202
<211>1200
<212>DNA
<213>智人
<400>202
gacggagutt ggatututut tgtggtuuaa agggaaagga ttgutgaatg taaaguuaat 60
gtuauuagaa aagutgaatu uauaagagag tuutggagtu uaaaagagua tutuatgggg 120
aatuaggaaa gttutgguat ttgguagatt aaguaagtgt uttgatttga agtuuagttt 180
agtuuuaata utuuutuuua uauuuauuau atcguauaat ttggttttgt ttatttautu 240
uaggttaagg tagagtutut taguttggtt tgagtgutgt aututtutut utggtutgat 300
atttggaaut aaaguuaagu uagaautuua ggguuaaggg ggatgttgaa aattgtutga 360
gtuuuuagau uauuutguua gutuatggua aagggaggga tuagagguua uagggaaagu 420
auttuagutg ututtuauag uatuauuutu tuuuuattta atggtttagg ttaauaggau 480
tttttuuttg agguttggga uacggaaggg aguutuuuut aaauuagguu uttggagagu 540
agguuuuagg ggaguagtgu aautuauutt uauauuuaua agacggutuu tgauttutgu 600
tuuutuutuu uutuuuuaaa gtggaauaga gagaatatga ttuuuuacga uttuuauatu 660
auagtttuua aauaatgggg aaatcggagg uutuuucgtg tguagacggt gatatttauc 720
guuaaatgcg aauuagguag atguuaguuu uaguacguac guaggtaaut tuauuutcgu 780
utuaacgauu tuagaggutg uucgguutgu uuuauacggg ggtgutaagu utuucguucg 840
ttutaagcgg agauuuaacg uuatuuataa ttaagttutt uutgagggcg agcgguuagg 900
tgcguuttcg guaggauagt gutaattuua guuuutttuu agcgcgtutu uucgcgutcg 960
tuuuucgtut ggaaguuuuu utuuuacguu ucgcgguuuu uuttuuuutg guucggggag 1020
utgutuuttg tgutgucggg aaggtuaaag tuucgcguuu auuaggagag utcgguaagt 1080
atataaggau agaggagcgc gggauuaagc ggcggcgaag gaggggaaga agagucgcga 1140
ucgagagagg ucgucgagcg tuuucguuut uagagaguag uutuucgaga uaggtaaggg 1200
<210>203
<211>1200
<212>DNA
<213>智人
<400>203
ggattauagg uatgtguuau uagguuuagu taatttttgt atttttagta gagatggagt 60
ttuauuatgt tgguuaggut ggtuttgaau tuutgauutc gtgatuuauu utuuttgguu 120
tuuuaaagtt utgggattau aggagtgagu uautgcguuu aguuauattt aaattttaga 180
gtataattat tgutguttat aattagaagt gagaagautg ttttgaagta agggauttuu 240
utgguuauuu tcgutaaaat tguaauutta uuutuautuu atttutuutt ututguttta 300
tatttutuua aaguauttat atgataataa autgtataat aucgtautta utgtgtttut 360
uatgtatuuc ggutauaaut gtuaautgcg tgggautggt tttgtutgtt ttgttuuutg 420
ututatuuut ggagcgtaaa guagtgtutg gtatagagtg gatauttaat agatattcgt 480
tgaaucgggu uagtggcggt ggutuacguu tgtaatuuua guautttggg aggcggaggu 540
agguagatua uttgaggtua ggagttcgag guuaguutgg uuaauatggc gaaatuucgt 600
ututautaaa aatauaaaaa ttagucgggt gttgtggtgu atuuutgtaa tuuuagutau 660
ttcggaggut gagguaggag aatcguttga auutgggagg cggacgttgc ggtgagucga 720
gatcgcguua ttgtautuua guutgggcga uaaagagaga uatcgautua aaaaaaaaaa 780
aattcgttga acggaatgag tgaauaaaua aatggatgga tgagtgaatg aatgaacgaa 840
ggaauaagtg aucgutcgau uttutauagc gauagcggcg uaggcgutuu cguauuaaua 900
guuuuuuauu ucguuaucgu uagagggcgu agauaggucg ggtuucgagt gtutgtuuua 960
gguuuucguu uuauaggatu ucgguucggg aguuuucgat guagggauuc guucgggaut 1020
utgggtuuuc guuuatauut uaauttcgua cgautgcgtg uutuaagucg acguagcggu 1080
utaututcgu autguagacg gggaaautga gguutgaggc ggucggggtg ggguagauut 1140
uucggcgagu ucgaguuuuc guuuucggut aguuucguuu tgguucgtaa gaaguauucg 1200
<210>204
<211>1200
<212>DNA
<213>智人
<400>204
aataaauttu uatgttgttg ttgttgtttt gaaacggagt gtuaututgt uauutgggat 60
ggagtguagt gguauaguut tggutuaucg uaauutucgu utuutgggtt uaagtgattu 120
tuutguutua guutuutgag tagutgggat tauagatgua uacgauuacg uutggutaat 180
tatttgtatt ttgagtagag atggggtttu auuatgttgg uuaggutggt gttgaattuu 240
tgauuttaag tgatutguut guuttgguut uuuuaagtuu tgggataaua gguatgaguu 300
autguauuua guuaaauttc gaggtatata attaaaagtt taataaguuu tuaguutaat 360
tttaaaattu agattutttu tttutttutt tutttcgttu tttutttutt tutttutttu 420
tttutttutt tutttutttu tttutttutt tuttutttut ttttutttut ttuttgataa 480
uattattatu atagtutggt agattutgtu tttutataat aaaaatuutg tgatgttgtt 540
uaaagaaaut uaatgggutt tutgtatgtt tauuaaggaa ttaaaatutt aauaaaggtt 600
ttuaauauaa gaaatautuu uttttgtaag aattuttuat aggtttttut aguauaagtt 660
tgtttttatt gaatgataut tgatggttut gtatgttatt tuttttutau tauatataat 720
tttgattagg ggatauatta aatattttaa aautatuatt tutttttuua gaauaatuat 780
aauatgtttt guttuttgtt gutttaaaag gaauatttta agttgutttt ttauaauaat 840
aagtgtgaaa ggaaatguua aaatauaaau aatttuautt uttgttggaa tttgauattt 900
uuautaguta agtaatataa auatguatua uutaaatgag uagtatttta ataguatcgt 960
tttuauattt taattgttgt uauatttutt utttgtttag ggagacgtut ggtgaauauu 1020
cgtgggatut aaagaauaag taagatttaa aguatautgg gttgtgtguu tggutttuau 1080
attttattta ttttattgut taatagtgtt tutttautau tgtgggttgt aguttaaaat 1140
tgttagaaat tttattatgg agtataagga ataaaagtga acgttuaaua utttuaaatt 1200
<210>205
<211>1200
<212>DNA
<213>智人
<400>205
uutguutttg uatagaattu utggaatguu ttttcgtuat uttgttaaaa tuutggttaa 60
auttuaaggu utagtttgag auautatttu uatgatgtua gtuttgatuu tatuttttat 120
aguattatut ggttttuutt uutggcguta atuauttatt aaattgtaut aatuatutgg 180
tgtauutgut ttattttuuu tautaatutg gaaauaaaaa taatagaauu tgautuatut 240
ttutguuttg agauauuttg tgutgtuaut uttgatguut tguauauagt aggtgututa 300
aaaatagttt gtgguttttt gattttauag agaagautga ggaaattaaa uuuttguuua 360
ggagguatat aaaaatuutg ttaaatgaaa gaggutuatg utaautattg ttttgautta 420
ttgatguuaa autagauttg aauattgatg tgtuttuagg gaagaaguua aatatgutag 480
tgtaaaaaat tutaauutut gutatttauu tggagaagtt gaattaguuu tgtuatttua 540
autgatguua aaaaaguagu ttuuattatt gtgtuagtaa tagautttta tuutguatgg 600
aggaauttut uttaaatutt tutuatagua utggtgtgut tutttguaut gatgtattta 660
cgtaatgttt uataagaagt gauagttuut tttttaggtu tttguuuaaa aggtgguata 720
aguaaagaat gaaagtuaag gtggttggut ttaggagagu utaaaattgg gaatgcgaga 780
gutuuuacgt aauauaaauu cggatagtut aagautuuta uattttauaa auuaagttat 840
ttuuttuuta atauaaauaa agtatgauag ttauaattta ttgtgtattt auaatggatt 900
gtgtutgtua tggtgattgt gatggaauua ggggggaaag agtaagaaat utaaguautt 960
ttgtgttttu ttuuttttut tttututtuu tuuucguttt uaggututga aagtgttuua 1020
gutgaaattt uagatcggau agautcgutg cggutucgga gguagtgatt uuaagutgut 1080
cgcguacgut gutguuaagu tguaggatgg tguacgtagu uaggutgutg utgutgutuu 1140
tuautttutt uutucguacg gatgutgaga gtaaguuatt utuuuuttut utagggggut 1200
<210>206
<211>1200
<212>DNA
<213>智人
<400>206
aaguaaauut agataaatgg gauttuatuu aautaaaatg uttutguauc guataggaaa 60
taatuaauaa aatgaaaaaa uaguutatag attgggagaa aatatttgtg aguuatatat 120
utgataaggg gttaatatuu aaaatauatt acgttuauag aautuaguua aaataaataa 180
ataaaauauu uagttaauta acggguaaag gatgtgaatg gauttttttt ttttttuuag 240
aggaagtaua aattguuaau aggtataaga aaaggcgutu aaaatuauta atgaauaggg 300
aaaaguuaut aggtatutuu tuauauutgu taggatgaut gttataaaaa agataagcga 360
taataagtgt cggtgatgtg cggaguaaag ggaauuttgt auautggtgg tgggaatgcg 420
gautggaaua guuattatgg aaaauuutac ggaggttuau tuaaaaagtt aaaaauagaa 480
utauuaguuu agtgttatuc gtuuttcgtt aagttuaaag tuacggtguu auttuutttu 540
uuatutaaag gggautgutc gcgauuuaag uuaagguucg uaagtgtggu tutuuutgcg 600
gggagagtag gguaggaggt ggatttuuag guuagaggut tuuaggutgg guucggauuu 660
uacgucgauu ucgguuucgg ggggggutua gcgauutcgg cguutuutua gguuuuuagt 720
gaauutucgg gguuuataaa ggutuuaggu cggutuuucg gagguuuauu agcgggcgtu 780
tggguutuuu tucgcgucgc gaucguuagg aggcgucguu cgggagagga agtuuagutg 840
gguucggucg gguttcggag gcgucguucg ggagaggaag tuuagttggg uucggucggg 900
uttuagaggc guagggcggg agucguutcg cguagggtuu tuuuuaaguc ggcguuaggu 960
uutguuutcg tucgguuutg uuutcgtutg guuucguucg ggucgcgagu autggcgggt 1020
tutgggtuut gtgaucggtu aggcggcgtu agcgggcgcg gcggagggut ggucgguutc 1080
gggggagttt ucgcggucgu cgggggcgcg gcgguagagc gcgaggucgg guaggggguu 1140
agautcggag tcgaggcgcg uucgauaguc guagcgutua tggcgggcgg aggagucggg 1200
<210>207
<211>1200
<212>DNA
<213>智人
<400>207
aguaaauuta gataaatggg auttuatuua autaaaatgu ttutguaucg uataggaaat 60
aatuaauaaa atgaaaaaau aguutataga ttgggagaaa atatttgtga guuatatatu 120
tgataagggg ttaatatuua aaatauatta cgttuauaga autuaguuaa aataaataaa 180
taaaauauuu agttaautaa cggguaaagg atgtgaatgg autttttttt tttttuuaga 240
ggaagtauaa attguuaaua ggtataagaa aaggcgutua aaatuautaa tgaauaggga 300
aaaguuauta ggtatutuut uauauutgut aggatgautg ttataaaaaa gataagcgat 360
aataagtgtc ggtgatgtgc ggaguaaagg gaauuttgta uautggtggt gggaatgcgg 420
autggaauag uuattatgga aaauuutacg gaggttuaut uaaaaagtta aaaauagaau 480
tauuaguuua gtgttatucg tuuttcgtta agttuaaagt uacggtguua uttuutttuu 540
uatutaaagg ggautgutcg cgauuuaagu uaagguucgu aagtgtggut utuuutgcgg 600
ggagagtagg guaggaggtg gatttuuagg uuagaggutt uuaggutggg uucggauuuu 660
acgucgauuu cgguuucggg gggggutuag cgauutcggc guutuutuag guuuuuagtg 720
aauutucggg guuuataaag gutuuagguc ggutuuucgg agguuuauua gcgggcgtut 780
ggguutuuut ucgcgucgcg aucguuagga ggcgucguuc gggagaggaa gtuuagutgg 840
guucggucgg guttcggagg cgucguucgg gagaggaagt uuagttgggu ucggucgggu 900
ttuagaggcg uagggcggga gucguutcgc guagggtuut uuuuaagucg gcguuagguu 960
utguuutcgt ucgguuutgu uutcgtutgg uuucguucgg gucgcgagua utggcgggtt 1020
utgggtuutg tgaucggtua ggcggcgtua gcgggcgcgg cggagggutg gucgguutcg 1080
ggggagtttu cgcggucguc gggggcgcgg cgguagagcg cgaggucggg uaggggguua 1140
gautcggagt cgaggcgcgu ucgauagucg uagcgutuat ggcgggcgga ggagucgggg 1200
<210>208
<211>1200
<212>DNA
<213>智人
<400>208
aagtguuuau uuaaataguu tuatuattgu tgagggtutg tauatgauag tgautggggc 60
gtagguagut guauauauua gggutgagtu uuaguauacg tgttutauut gtgtgautuc 120
gaguuttaut tttutuatut gtauauagtu tutgtutuaa ggutattgga atgagtuaat 180
gatagagtgu acgtaaatua uttguauaga gagttgttua aauaatggta gutagaautg 240
utattgatut attgtggggt aattgtutta autgutttga aggattuagu uutatgtgtt 300
uutttgtuua gtuagatggg aaaatataaa tgaguuuttu tuaatgttag gaatgauaag 360
atuagguuaa gauuuututt tutuagauta tucggaagat auauagatga uutggauagt 420
gtutguaggu tuutgtgtat uutgaggutt uutgaggguu aagttutatg ggtgggaagg 480
uaguttgutu tutaggttgu uataaututg uatutgattt guatgtgttt gtggtgauuu 540
tguagtttut tutgguattt uuaauttaaa atattgutgt ttuuuuaggu aggguagata 600
ttgatttttt tuttututaa uuattucgat tgauucggut uuuuuauuua gcgaatgggg 660
gagggagggg gtgggggtga ggaagtggat gggggagaag ggaggaggga tggtgttguu 720
uttataguta guauutttta utucgtggaa uutgagtuau cggggutgat gagaatgggu 780
tutttuuaga aguaagtgua tgatgaagaa agaauagagg gaatgttuuu uutcgggtuu 840
atuutggtuu uttutttuuu tguatuuutt atatgauutg uagttuuutg agtuuauttg 900
uuaucggggg cgggtgguau uuaggcggcg gggaggcggg ggaggggcgu agtgauaguc 960
gagucggutt tgaggaauut tguagaggaa gtgguttuag aautguttta cgcgaggggu 1020
aggaaaggcg cgggaggcgg gggaggtgcg gagatggcgu tutguacggc ggcggaggga 1080
gggcgutggc gucggggaua cgaaaucgua gaguucggac gagtuaggga gtgaggcgcg 1140
agucgggcgu ucggggutut guaggcguag gcggcgcggg gauaggagua ggttaucggg 1200
<210>209
<211>1200
<212>DNA
<213>智人
<400>209
uttgaaguaa guuttuacgg gggaaagtgu cgggagaaag gagatututu tttgggtuuu 60
atgagtgaau uatuuatauu aggttuuaut taggguattt aggggaautg gtatutuuau 120
agtaattaut agaguagutu tggggaacgg agggttggut aaggaagaaa agutuuuuua 180
auuuttgggg cgagggagcg ttututuaat ggaguuuuuu uaautuuuut uuauuuuuua 240
uuagtuttuu aggaaagagg aatauuutau ucgguagggu tgcgaaggaa ggggaaatuu 300
aauuagagcg aaagtcguac gcggauagut utguuaguuu ttggagguat ucggcggtua 360
uuuacgggau aaagcgcggu tgcgggagcg cgcgcggggu attucggauu cgcgtcgagu 420
tucgututag agggggcggc gggcggcgau aagucggaga gaggaagggu uaaggaguac 480
gguuutuutg tcgguauuat uagcgggaga gtggcgagcg gacguutaga cggagggguu 540
utautuagau uuuatcgagu uagttuuuaa guttttuuut ucgauutgut uuutuucggg 600
gcgcgtgagg gtgcgggtcg ggggtgaauu tggtgttggg gaaagtgatt gguaagggaa 660
agagguaggg utgaagguut aggguuuuuc guagaaatgc guuututgag utgtautgta 720
uagaggcgut uututgcgga atuutguagu tgutuuaggt gaagacguuu uuaaatuuau 780
autcgcguag acgtcguutg guacggauuu tauuuuuttc ggtucgtcgg cggttututt 840
gggtcgtuut tuutguuaut ucgaututuu ucguuuucgu uucguuuagu aggutgcggt 900
tuutttaaag gcgcgutggt gtggggcggu uuuttututc ggggutggut cgggagtagc 960
guagtcguua aagucgucgu tguuaaagut gucguuauta gucggguatg guuatggcgt 1020
uuucgguuat cggguagcgu ucgtauucgu tautattgga uuucgagucg ucgcgutatu 1080
tauagaguut gagcgguuuc gagutaucgu cgucguuuuu cgaucggtuu tcgcguutut 1140
gtgtuucggc guuuututuu autgcguucg gggcgcgcga ggggcguagc guucggaggg 1200
<210>210
<211>1200
<212>DNA
<213>智人
<400>210
ttuaagatgg tgaucguaga gcgttaaauu agauaagggt uuatgaaggu ttgaaguaag 60
uuttuacggg ggaaagtguc gggagaaagg agatututut ttgggtuuua tgagtgaauu 120
atuuatauua ggttuuautt aggguattta ggggaautgg tatutuuaua gtaattauta 180
gaguagutut ggggaacgga gggttgguta aggaagaaaa gutuuuuuaa uuuttggggc 240
gagggagcgt tututuaatg gaguuuuuuu aautuuuutu uauuuuuuau uagtuttuua 300
ggaaagagga atauuutauu cgguagggut gcgaaggaag gggaaatuua auuagagcga 360
aagtcguacg cggauagutu tguuaguuut tggagguatu cggcggtuau uuacgggaua 420
aagcgcggut gcgggagcgc gcgcggggua ttucggauuc gcgtcgagut ucgututaga 480
gggggcggcg ggcggcgaua agucggagag aggaaggguu aaggaguacg guuutuutgt 540
cgguauuatu agcgggagag tggcgagcgg acguutagac ggagggguuu tautuagauu 600
uuatcgaguu agttuuuaag uttttuuutu cgauutgutu uutuucgggg cgcgtgaggg 660
tgcgggtcgg gggtgaauut ggtgttgggg aaagtgattg guaagggaaa gagguagggu 720
tgaagguuta ggguuuuucg uagaaatgcg uuututgagu tgtautgtau agaggcgutu 780
ututgcggaa tuutguagut gutuuaggtg aagacguuuu uaaatuuaua utcgcguaga 840
cgtcguutgg uacggauuut auuuuuttcg gtucgtcggc ggttututtg ggtcgtuutt 900
uutguuautu cgaututuuu cguuuucguu ucguuuagua ggutgcggtt uutttaaagg 960
cgcgutggtg tggggcgguu uuttututcg gggutggutc gggagtagcg uagtcguuaa 1020
agucgucgut guuaaagutg ucguuautag ucggguatgg uuatggcgtu uucgguuatc 1080
ggguagcguu cgtauucgut autattggau uucgagucgu cgcgutatut auagaguutg 1140
agcgguuucg agutaucguc gucguuuuuc gaucggtuut cgcguututg tgtuucggcg 1200
<210>211
<211>1200
<212>DNA
<213>智人
<400>211
tautuaggag guuaagauac gagaatcgut tgaauutgag gggatggggg guagaggatg 60
uagtgagucg agattgucga gatagcguua utguattuua guutggguaa uagtgagagu 120
utuuatutua aaaaaaaaaa aaaaaaatgg auttuttuut uattgauutg tggtggutuu 180
aagguuatua aaaaaaaaaa aaatggautt uttuutuatt gauutgtggt ggutuuaagg 240
uuatuatutu auaguutttt tttttttttt tttttttgag acggagtutt gutuuuttgu 300
uuaggttgga gtggagutgu atgatutcgg utuautguaa uutucguutu uuaggttuaa 360
guattutuut guutuaguut uutgagtagu tgggattaua ggcgcgtguu auuacguuua 420
gutaautttt guatttttaa tagagacggg gtttuauuat attggtuagg utggautcga 480
autuutaauu tuatgatucg uucguutcgg uutuuuaaag tgutaggatt auaggcgtga 540
guuautgcgu ucgguutuat utuauatutt tuttuututg uaguauacga uacguuutag 600
ttggaaauaa agtcggagtt tgtggattgg gggaagggcg gggtutaauu tuaggtuagg 660
cgucgtguaa ggtauatutt gguauucgga agagguuuag tauagttguu uucgaggtga 720
uucgauutuu uutauuaatt gaggcguuut tgttguuagg uttgcggcgg gggagcggcg 780
ggggagcgac ggggatgcgu tuattggtua aggaaggggc guutgttaut agaggcgaga 840
aucggaguuu attggtcgga auauutuaua atggauuuua gcggcgcgua aaatuuttat 900
gattggtttg utggutguut cgggagauuu tgttguuagg atauttggcg ttuucgauuc 960
gauuuucgtt uuuuattggu tgtuagggua aaagucguua tutaatgagg agcgaggtgc 1020
ggtguuucga agcgutcgut tuucgcggtg cgatutagtu utguagtagg cgguucgggg 1080
uuauaucgcg gucguuuaag uuagtguaag guuuaggggu utgauatcgu tuuuagcgut 1140
cgaggaucga gguutgutgt ggaggauauc gtgutuuutc gggauutgut utggattucg 1200
<210>212
<211>1200
<212>DNA
<213>智人
<400>212
uaaaaaguag ucggggatgg ggcgagaaua gaggauttuu uuautgaguu uauatuuaau 60
utuauuuaga auuuuttutu aggtuuagtt gutgutuuut attaggggta aatgtgttta 120
tgcguatuat ttuuatuatt tutttggggg aaaattggat tutttuutuu tuutcgutau 180
tcgututucg aututguuag uuuatutuut gagagttutu utgtgtaagg gatguaaggg 240
uuauuaguau uaggtututg aaaggacguc ggaguuagtt tucggtttuu aagggttgga 300
uuagtgutgg aggggggaat uauaaautgu uuttuuagga uuutauuutu tutautauuu 360
uaggatgutg aaaaagguta ttutguutut uttuuuutgu tuagututtu uucguutuut 420
guutucgguu uuaguagagg ucgcgutuuu autgcguutu tcguututga gaaatggcgu 480
aguaagcgut ucgcggagag uutggaggcg gggcguuutt ututgagtuc gcggggtcgu 540
auuucgaguu agtcgguuag auutguatuu cgcgtaguat uuutguuutu tutgtguagc 600
ggaaagggua aaagguaggg autguaagcg ggcgcguauc gggtaggaag agcggututg 660
cgtaggtgcg cggauucggg utuutgggtt uuatuuucgu cgcguauutc ggggtucgua 720
uucggutuut gucggguuut tttcggucgu auuucgutuu cguauuucgu tuutuuuuaa 780
guuuuauucg guuuaagucg cgcgtuucgu autgagutuu tauacgcguc gcguuucggu 840
cguauuucgc guaguuagag uaaguautgg aguuucguuu uttuucguau uuuauucguu 900
tucgguuucg uutgguuuau uuutggaucg uuuucguuuc guuucguuuu tauucgutuu 960
tucggcguag ucggcgutta uutcguttua gtuucgcgau cgaaguaggg cgcguaguag 1020
cgutgagtgu uucggaacgt gcgtcgcguu uuuagtgtuc gtcgcgtucg ucgcguuucg 1080
ggcggggatg gggcgguuag autgagcguc guauucguua tuuagauucg ucgguuutag 1140
ucguagtuuu tuuagucgtg guuuuagcgc guacgggcga tggcgaaggc gacgtucggt 1200
<210>213
<211>1200
<212>DNA
<213>智人
<400>213
gauutuaaaa aguagucggg gatggggcga gaauagagga uttuuuuaut gaguuuauat 60
uuaauutuau uuagaauuuu ttutuaggtu uagttgutgu tuuutattag gggtaaatgt 120
gtttatgcgu atuatttuua tuatttuttt gggggaaaat tggattuttt uutuutuutc 180
gutautcgut utucgautut guuaguuuat utuutgagag ttutuutgtg taagggatgu 240
aaggguuauu aguauuaggt ututgaaagg acgucggagu uagtttucgg tttuuaaggg 300
ttggauuagt gutggagggg ggaatuauaa autguuuttu uaggauuuta uuutututau 360
tauuuuagga tgutgaaaaa ggutattutg uutututtuu uutgutuagu tuttuuucgu 420
utuutguutu cgguuuuagu agaggucgcg utuuuautgc guututcguu tutgagaaat 480
ggcguaguaa gcgutucgcg gagaguutgg aggcggggcg uuuttututg agtucgcggg 540
gtcguauuuc gaguuagtcg guuagauutg uatuucgcgt aguatuuutg uuutututgt 600
guagcggaaa ggguaaaagg uagggautgu aagcgggcgc guaucgggta ggaagagcgg 660
ututgcgtag gtgcgcggau ucgggutuut gggttuuatu uucgucgcgu auutcggggt 720
ucguauucgg utuutgucgg guuuttttcg gucguauuuc gutuucguau uucgutuutu 780
uuuaaguuuu auucgguuua agucgcgcgt uucguautga gutuutauac gcgucgcguu 840
ucggucguau uucgcguagu uagaguaagu autggaguuu cguuuuttuu cguauuuuau 900
ucguutucgg uuucguutgg uuuauuuutg gaucguuuuc guuucguuuc guuuutauuc 960
gutuutucgg cguagucggc guttauutcg uttuagtuuc gcgaucgaag uagggcgcgu 1020
aguagcgutg agtguuucgg aacgtgcgtc gcguuuuuag tgtucgtcgc gtucgucgcg 1080
uuucgggcgg ggatggggcg guuagautga gcgucguauu cguuatuuag auucgucggu 1140
uutagucgua gtuuutuuag ucgtgguuuu agcgcguacg ggcgatggcg aaggcgacgt 1200
<210>214
<211>1200
<212>DNA
<213>智人
<400>214
tuuuuuuatg gaggutguuu tutagttcgt uutttagagg aaguatgauu aagggtutgu 60
tggtautttt ututuuutut utaagaattt uutuaggaga ggaaaaagtt agutttuttt 120
tututgutuu tgagtguuat gguutguagt acgtgauuag tuuttgguau agagtuautu 180
agggutuatg gtagatgutt agcggtuaua guuagtagut gcguagtgtg guaguagutg 240
agatuuatau tguaguutga aagttgtgtt tuaguttutg aggttauaag tgtatuuagt 300
gtttauatua gagataaagu uuuutttuuu utututuuta cgggaguuut uaauaagaua 360
gatauacggg ttgggtggag tgagauuaua tuuaguagag guaaaguttg utaaaagaga 420
gaggaggagg agggggagag ggaggaggcg guacggcgtu uuttgguagu tucgtguatg 480
utgcgguagt tguaauagga gaaucgagta uuagttgutu aauautttat uautttguat 540
tgututttut uutuuuttaa gtgaatttuu attttgaggg tauagutuua uaggagaaag 600
gtgtggtggt ggtagtggtg gagggtgtut gtggggggga tggtggtgcg acgggagttg 660
gaatgtuuag tgtggggaag uaaaggagtg uutautagga tgcgaatauu auttgguuut 720
gggutcgutu cgutttaguu ttuuuututc gutggggaga aauaggcggt ttgtgaggga 780
gautgagaga ggggcgtgtt tgtggtggtg gcgguuuatc gggggtuutt gtuututucg 840
aatauucgga utgutgaggg gaagggucgg ggggguuucg gcggttguua tggtgacgua 900
gggtcggcgg utuagcgucg tagagauaaa gucguucguu cguuaguucg utagutuutc 960
gcgcgagutu utuutuuacg ggaauutuuu tuuuutuuua ggcgucgucg uagucggagc 1020
ggutuucggg uuutgggucg ucgucgguua ggtaaggcga tcgcguucgc ggucggggag 1080
gggtcggcgg gacgucgggu utuuuuaacg utgggguagu aguuaguuuc guagtuutgg 1140
acggcgucgg gucguuuaag cgcgucgagg agagggggcg guaaauttcg ggucgagcgg 1200
<210>215
<211>1200
<212>DNA
<213>智人
<400>215
gagggagaga tguagggagu tggattttag utuutaaggt agaaaatttu uaaaaggutg 60
atuaaagatt aaatggutgu uttaaaaggt aatgagttuu ttgttagtgg aggtgttuaa 120
uuautguttg gtgggaagau autgtaagga ggattuaggu aagtgggaag gggguttttt 180
uuagtuuutg aaatuaatga ttutaauagg aaaagatgut ucggggtgcg gtgagcgutt 240
auututgutu ttguagagau autgauagac gttuattuaa uatutgttuu tguuagguau 300
tgtgcgcgut gaauauagaa gtauaguutu tatgaaguag ucgutgtagg uutuagagau 360
agutgataga tgtaauautg ttgtutuuat gtttuaaaut tcggtuatgg tuttautagg 420
tutuutuatt aaggggautu autatgtgtu uagtaacgut ttuttgttau uagatgauag 480
agagtuaggu tgtuagagtt uacgauttta ggtguauagt ttuauuutgt utggtuuttg 540
ggagacggag aaggggtuag gagaaaacgt gggtgaagag guaguaaagu cguaggagat 600
atgaautaat tgutuaacgt gggtgtagua cggattaggu uttttauagu aagcgutguu 660
aguagggaau tggtggatgt aututtgauu acgutcggut ggaututggg gaguuuaaga 720
cgggtaagau taggtuuucg guuuuaguag utggtggggg cgucguaggt tagagacgtg 780
aggucgcgag gutgagggut gtgaaggcgg tggguacgua cggcgtgucg gggucguutg 840
guttcgcggc gggggaggta auautgcgau auuucguaga cgutgtuagu cggggtcgcg 900
guuucgcgtg cguucgatua tutgautgut ggggagtgcg ggggcgcggg aguuaggcga 960
guuagcguag gcgcgcgutg uutuutucgt uuuuaucgag tuuuuagcgc gtgcgcgggg 1020
ucgtggucga gguutgcgcg ucguucgguc guutguautg cgcgcgcguu uauuucgcgt 1080
gggagguagc gggagggguu cggagaggtg tggagcggcg cggcgggagg utucgtgggc 1140
gguuacggga gauagcgucg gcgggagcgc guututcggu utttuutucg cguuuucgcg 1200
<210>216
<211>1200
<212>DNA
<213>智人
<400>216
ttagutuuta aggtagaaaa tttuuaaaag gutgatuaaa gattaaatgg utguuttaaa 60
aggtaatgag ttuuttgtta gtggaggtgt tuaauuautg uttggtggga agauautgta 120
aggaggattu agguaagtgg gaagggggut ttttuuagtu uutgaaatua atgattutaa 180
uaggaaaaga tgutucgggg tgcggtgagc guttauutut gututtguag agauautgau 240
agacgttuat tuaauatutg ttuutguuag guautgtgcg cgutgaauau agaagtauag 300
uututatgaa guagucgutg tagguutuag agauagutga tagatgtaau autgttgtut 360
uuatgtttua aauttcggtu atggtuttau taggtutuut uattaagggg autuautatg 420
tgtuuagtaa cgutttuttg ttauuagatg auagagagtu aggutgtuag agttuacgau 480
tttaggtgua uagtttuauu utgtutggtu uttgggagac ggagaagggg tuaggagaaa 540
acgtgggtga agagguagua aagucguagg agatatgaau taattgutua acgtgggtgt 600
aguacggatt agguutttta uaguaagcgu tguuaguagg gaautggtgg atgtaututt 660
gauuacgutc ggutggautu tggggaguuu aagacgggta agautaggtu uucgguuuua 720
guagutggtg ggggcgucgu aggttagaga cgtgaggucg cgaggutgag ggutgtgaag 780
gcggtgggua cguacggcgt gucggggucg uutgguttcg cggcggggga ggtaauautg 840
cgauauuucg uagacgutgt uagucggggt cgcgguuucg cgtgcguucg atuatutgau 900
tgutggggag tgcgggggcg cgggaguuag gcgaguuagc guaggcgcgc gutguutuut 960
ucgtuuuuau cgagtuuuua gcgcgtgcgc ggggucgtgg ucgagguutg cgcgucguuc 1020
ggucguutgu autgcgcgcg cguuuauuuc gcgtgggagg uagcgggagg gguucggaga 1080
ggtgtggagc ggcgcggcgg gaggutucgt gggcgguuac gggagauagc gucggcggga 1140
gcgcguutut cgguutttuu tucgcguuuu cgcgtuuuua gucggucgut ucgagaggau 1200
<210>217
<211>1200
<212>DNA
<213>智人
<400>217
auaaaaaaat tuuaatagtg attagtaaua auuagataut gtgauagtgu uuuattguua 60
ttuuatggga gatguaagag uattgtutua gtaataaaat atgatgttat uagguattta 120
tggutuutgg ggaaaaaaat guaattgutt gutgttttga tattatutut gautatgutt 180
guttatuatt tguuatttut atatttagta guuagtuatt ttgaagttaa aaaaaaatua 240
aggtttguat tgtaauuaua aauuagtutt tgtgaauagg aatuutggag gutattaatu 300
aguttttaaa ggaggtaagt uatggtggtg gtggggtatu tgaaattttg gaagttucga 360
gutuauttta agagttgaga tgggtgggag ggutgaaaau auuauuattu atuattuttu 420
agttatutcg agautuaaut taaauatttt taatuaaaaa gatgggaggg gauacgggtu 480
auatutuagg tttgggggaa tgtgtgtgcg tgtagatgtg aaaautgagu uaaaatattu 540
uautgtgaag agatutuuut tutcggutgg tggauatuaa uuttauuaag taatutttgg 600
aguaagtaau tauuaaataa agucgttuua aaauttutac gtaagutuut autttttaat 660
gagtacguat ttutuuuuat tttuttttuu tutuuaagga utgagatagu tggaguaagg 720
atgggtuuuu ututgatttc gtuuucguuu uaguuaatut gaguucggat gutaattagu 780
tgcgutuuuu tgatgaauac guutttgtua uaagtagguu cggautauaa aguuuagaat 840
guutuauuuu tuuutgatua atgagggutt atttaaatga tututgaggt uttggauuua 900
gguuaatuag utgtuagggu tuatgataaa tcguaatgua ttattgataa taataattau 960
tgggauatgc gcgttucggu cgaagggggg taaatttuuu aautuuagga atttgtggcg 1020
gagaggguaa ataautgcgg ututuucggc guuucgatgu tcguauuatg tcgaggcgua 1080
aguaggcgaa auuuuaguau atuaautcgg aggaggauua gggcgaguag uagucguagu 1140
aguagauuuc ggagtttgua gatgcgguuu uagcggcguu cgcggcgggg gagutgggtg 1200
<210>218
<211>1200
<212>DNA
<213>智人
<400>218
tgtaauatgg auutututgt gacgcguaag tattatutgg uagttauatg gtgucguutg 60
tguagutggg cguuauuauu aguttuutgu uutgtgcgat taaaagguua guttcgggga 120
uaguaguutu utuaacguaa agcgauuagu uutguuaggc gtcggutgua gutggtuuaa 180
ggttgacggt uuuagggucg uattutuutt ucggtuauut uagaututgg aaagagaguu 240
atggaggguu tuagagcguu uututguagt tuuttgagga aaauaagggu utuuuuutut 300
tggutggagu aguuaagtgu uuacggggaa aatggtuucg tuuauuattt uagguaaacg 360
uuuuuatagu tgtaataaau atgtgatggg tttuutguau uaagaaagga aaattttuut 420
taaaaataau aaaaagaggt ggggagggga ututaagttu uatttaagat tttuuaaaut 480
cgttgtgtut uatguatacg utgaggutta auatgaaaat ttggagcgaa agtuuuuacg 540
gttuauuaua gggaatgaag taaagtatut cgucggtagu tutaggtutc gtaaaucgtg 600
gagutuuttt agtataaggu uutattatgt guuauattag atgagaagaa aataagagga 660
aggatacggt agaguuttta gaatggggtt uagtuttagg autcgtagga taaaggaagg 720
tcgtttuuut ucgtttgagg uagggaatua aauaaaauau cgguaucgua gguaucguag 780
tcguautuut gggguutcgt ggutttuucg cgcguucguu ttgggggcgg ggaagaauuc 840
ggatggaauu auuuttguag uucggauuuu ucgucgtutt tgaatgguag cggggcggag 900
ttguuutuuu ttutgtgutu tgautggttt ggutucguau tutuututtc gtgattgggu 960
tttuutagtg uuagtuauag agcgacgutg gtutuuuaga ttgttguaga aggagacggc 1020
gtcgacgtut gautggautc gcggcgautt auutttuagt cgtgcgutuu tgatucggcg 1080
utcggaattt gtuuucggut tuagggutgc gggguutgga aggaggcgta tcgaggcggu 1140
tcgaaaacga tuuaggggag ucgaggcgut uututtgtua tuuuautuag cguuatgtuu 1200
<210>219
<211>1200
<212>DNA
<213>智人
<400>219
tttaaaagtu uuautgaaaa uttttttttt ttuuagatcg aaauauaagt ttaatagtua 60
ttuagatttu attuuagtut aaagaaautt atagaaatut aattatutgu uagaataauc 120
gutttaaaut gautgtaaga auuauagtta utttguagut aaaauagatt gttututtuu 180
uuuaaauaaa utcggauatt tagauaaata ttgutgutgt utttauattt tagaaatuag 240
tattaaggut uauutgttau tgaauauata cgagaaauag ttttgttatg cgtatuttat 300
atauatuatg tatauatttt cgtautttua uatgatgtgt ataataagat auauataaaa 360
autggttggu ttgtuatgag taaatguttt attutttaga gtgaaggaat attggataua 420
gaacgtcgtt uuatatttaa tuttguttta gaaaattagg atttatuttg gauauaguat 480
tttgaatata auauagguaa gttgagtuut gggggaaaaa ttgtattttt aaatttatta 540
tuaacggtgt utttcguatt tgagaaaaua uatttgaaga tguuuatgua gttuuttgga 600
agtaaautag gtuauuuauu autgaaauau uutcgguttu tguaaaaaga tgtgutttaa 660
agagaataga atggacgutc ggtatgttua tutaaacgau uttggguaag tacgtcgatt 720
uuaaggtaua atuaguuutu uuagacggut tttcgagtut uuutaauuuc ggtgggagag 780
gacgcggcgu uagaguuuag utucggutag ttttuucggg gguaggtgta guuttgggcg 840
cggggucggg ggagggguaa ggggcgggcg tggggttgga utgggacgtg ggautcggau 900
uacgguutgg gcgtggguut aacgacgcgg gaucgguucg uuutcgucgu tuuattgguu 960
auatutgtgu agaaaagguu ucgcgguuua ggggcguucg uagtgtuaut aggucggutg 1020
gggguuutgg gtacgutgta gauuagaucg cgauagguua gaauacgggc ggcgguttcg 1080
ggucgggaga uucgcguagu uutcggggua tutuagtguu tuautuuuua uuuuutuuuu 1140
cgggtcgggg gaggcggcgc gtucggcgga gggttgaggg gagcggggua gguutggagu 1200
<210>220
<211>1200
<212>DNA
<213>智人
<400>220
tgttutuuag aguaggaaau aaguttggag agtgcgataa utaguuuaag uttuauaatg 60
ggtgagtggu aggautgagg tttgattcgg gtututtuuu agagagauau tgggagagat 120
tuttguuuua ggtuttttuu uttuagguuu tuaggutuag uauutututg aauatutgtu 180
uutggggagt gagaatutga autaaaatgt aaguuaagaa aauauaggut uttuattgaa 240
tutttggaaa utuutttuut gggutgtagg aggauuttuu tgaguuttag guauttttgu 300
utttgutggu tutttuutuu aagtuaagua tattttatga utgtggaggt ataaatauaa 360
atatattaau attatatagt aaaauatttt gtttgauata aattttttut tutgattttt 420
auagaaaaua ttttuataga tutuuaaaag tatcgtgggu uutaagcgut gtagutaagt 480
cgtttutuut ttutuaguut uuagtutgau atgttuuaut atgguuttgg gaagaguaat 540
ggguucggag tcgucguatu taauuutgut gtaautggtc guaagtuaua gtttgutuat 600
utataaagtg agcgaaagta atgtaatutt tattgggagt agggaauatg aaggcgagtc 660
gatauagtaa gtaagucguu aaguatattg utagguauag aguaggtgtg uaauaaaagt 720
tatttutuag gutttuuutu ututgagcgu cgtuutuuag agggtucgga gtgtagutgg 780
gggttggagu aguaguutuu taggcgatgg gauagaguuu auagggtucg gtatguuacg 840
gtttuttcgt uagauuutgg gaatuuaacg tcguaaaata aauacggucg cgucgutaat 900
cguuagttcg gaggaaauaa aauagcgutg cgutggggga tutggguaaa atuaguuutu 960
uutuutuucg utuuttcguc gcgguuutuu uutuutcgcg utgututcgt tcguttggut 1020
uagutuagut uagutuagcg uagutucgcg gucguuaagu cgaggcgggu acggtutucg 1080
agtcgcggac guuagutucg agutuuutut utucgucgcg uutucguuag gtcgcguutt 1140
cgtcgggauu auttcgggua ggagtcgcgt ggcgaagguu tgcggucgcg guauaaagtt 1200
<210>221
<211>1200
<212>DNA
<213>智人
<400>221
agagggttua agtttagatt tuaggutaaa uttutgggut tagagggtuu tgaguatggg 60
autggataaa ggagggaagu uatuatutut tuagaagatg ttuagaaaag gguatauauu 120
uagtutatut gagutgggag agagutgutg ttatguuutg ggguaggggg atggatgaaa 180
tgguatttga gggutuagat tututttggg guaagauutg auttuutatg gautuuuagg 240
aguaguaggg gagttutgag aggaautgtg attgtuuaga gtggagtttu tttgagautt 300
guuutgtauu taauuuuaaa uagatttgat auttagagau ututaauucg guatutuatt 360
gtauagutgg gaaaautgag auuuaggagg aagggguutu tucgagatgu uauagtgagt 420
uaagagtuut uauttuagag ggutggagaa taatutautg agguaggguu aggguauutg 480
tutgagaggg guttutaagg utguaagutt ttuuuuttuc gtggautgua ttuauauutt 540
gttcggtuut gutggggucg gggututuut tuuttguuuu ttttuuttgg uaututttuu 600
auagguuutg tgtggtutgg gututaucga gaggtuuuua aggagagutg gcgtgtuagt 660
uaguuaagaa guaaguaggu agguaatguu aguatguagg tggcggggut gguaggggag 720
ucgguaggag ggucggauau ucggagucgg ggaautgtaa tgttuaggga atttuaattg 780
guattgutgt uucgttuuag uuaautggut aacggtgucg agtttgaatu agtgauucgu 840
utuutggtuu utuutuutta gucgguutut utuuutuuut uuttttttuu utuuutcggt 900
gguuttuuag gaggcgggag gcguucgutg tcgagguagu tgaguuucgg uaaucgutgu 960
tutucguutu tuuuutcgcg gggucggutu atggagcgua gggaucgggu tggututcgu 1020
cgaguuucgg guututttta guutcgtuuu uagagaggga ggagucggtg uucgguauag 1080
uuucgucggu uutagaagut uuuuacgcgu uauuatguut utgutggacg ttttutggtu 1140
ttguttuagg aaggtgaagg taagtgautg guuaguuuua guuuatuucg utgutuaggg 1200
<210>222
<211>1200
<212>DNA
<213>智人
<400>222
agtgtgagau uaguutgggu aauataguaa gauttuagut utauaaaaaa tgtaaaaatt 60
agutgaguat ggtgguauau auutgttatu utagutautu aggaagttga gguaggagat 120
tttuttgauu auaggagttu uaggutgggt agutttaagt gagtuatgut taaagtutgu 180
tuagtttutg tutttgtaaa tgtgagggat aguagttgaa utguatgagg tuutggatau 240
tutuagauut gautaatagg agtuutuaat tuaauaatga aatuaaggtt gtgaauttgt 300
gttggauuut tgtgatgaaa gguuagagag aaatuaaagu cgaaggutut tgtttuttau 360
tgaatttgaa tggautttut ggtggtgutt autatuagaa utuutggaag uuutuuuutg 420
uuacgattaa tgttcgtguu uuaaattttu uatguatttu tutgcggagg tagagttuag 480
auttggggta ggggauagaa guutggggta ttggggaagt tguagaguua utgggguutg 540
aguaacgtag ggatgguagu ttuutgutua aattuutaat tatutggttt tuuuutauua 600
attggagatt tuautgaagt tgtgtuttut ggauatuuua taaattatuc gaguaagtua 660
utgaauuutu ucggguauat aguatatgtg tttaaatuuu uuaaauagtg ucggautuat 720
tuagaautua ataaatatta guutgtgtgu utgguuaagt uautguttga guutuagtut 780
ttggguttgu auutuutuuu tgguagcggt gtgaucggag ggaaagguag cggcgagggu 840
uttggaggau utguagguag tguuucguuu auuuagattt gggtgauttt utggcgagtu 900
cggtggguua gautgcguuu uuattggucg aggggaggtg ggcggggcgt uuutauaguu 960
utautcgucg acgutuuutu uuuauttgag utgagtggau tcgggttgau aacggutaag 1020
uagucgcggu agutgututt utggutggua ucgtuauuuu tguucgauuu uagguuucgc 1080
gtgtgtuucg gacggaguag tuuutuutgg gutcguutuu tguucgutcg ututgtgtua 1140
gcguucgaau uuaaaggggt ggacgcgguu tuuaggtagg agtutgggcg acgguagggg 1200
<210>223
<211>1200
<212>DNA
<213>智人
<400>223
gggutgagag agggggaggg tuautguttu ttaatggutt tutguuuaga aaguututag 60
aautguutgu tgutgauttt utttuutttu aggguatuua gagggttuaa gtttagattt 120
uaggutaaau ttutgggutt agagggtuut gaguatggga utggataaag gagggaaguu 180
atuatututt uagaagatgt tuagaaaagg guatauauuu agtutatutg agutgggaga 240
gagutgutgt tatguuutgg gguaggggga tggatgaaat gguatttgag ggutuagatt 300
ututttgggg uaagauutga uttuutatgg autuuuagga guaguagggg agttutgaga 360
ggaautgtga ttgtuuagag tggagtttut ttgagauttg uuutgtauut aauuuuaaau 420
agatttgata uttagagauu tutaauucgg uatutuattg tauagutggg aaaautgaga 480
uuuaggagga agggguutut ucgagatguu auagtgagtu aagagtuutu auttuagagg 540
gutggagaat aatutautga gguaggguua ggguauutgt utgagagggg uttutaaggu 600
tguaaguttt tuuuuttucg tggautguat tuauauuttg ttcggtuutg utggggucgg 660
ggututuutt uuttguuuut tttuuttggu aututttuua uagguuutgt gtggtutggg 720
ututaucgag aggtuuuuaa ggagagutgg cgtgtuagtu aguuaagaag uaaguaggua 780
gguaatguua guatguaggt ggcggggutg guaggggagu cgguaggagg gucggauauu 840
cggagucggg gaautgtaat gttuagggaa tttuaattgg uattgutgtu ucgttuuagu 900
uaautgguta acggtgucga gtttgaatua gtgauucguu tuutggtuuu tuutuuttag 960
ucgguututu tuuutuuutu uttttttuuu tuuutcggtg guuttuuagg aggcgggagg 1020
cguucgutgt cgagguagut gaguuucggu aaucgutgut utucguutut uuuutcgcgg 1080
ggucggutua tggagcguag ggaucgggut ggututcguc gaguuucggg uututtttag 1140
uutcgtuuuu agagagggag gagucggtgu ucgguauagu uucgucgguu utagaagutu 1200
<210>224
<211>1200
<212>DNA
<213>智人
<400>224
tggggagggg utgagagagg gggagggtua utguttutta atggutttut guuuagaaag 60
uututagaau tguutgutgu tgautttutt tuutttuagg guatuuagag ggttuaagtt 120
tagatttuag gutaaauttu tggguttaga gggtuutgag uatgggautg gataaaggag 180
ggaaguuatu atututtuag aagatgttua gaaaagggua tauauuuagt utatutgagu 240
tgggagagag utgutgttat guuutggggu agggggatgg atgaaatggu atttgagggu 300
tuagattutu tttgggguaa gauutgautt uutatggaut uuuaggagua guaggggagt 360
tutgagagga autgtgattg tuuagagtgg agtttutttg agauttguuu tgtauutaau 420
uuuaaauaga tttgatautt agagauutut aauucgguat utuattgtau agutgggaaa 480
autgagauuu aggaggaagg gguututucg agatguuaua gtgagtuaag agtuutuaut 540
tuagagggut ggagaataat utautgaggu aggguuaggg uauutgtutg agaggggutt 600
utaaggutgu aaguttttuu uuttucgtgg autguattua uauuttgttc ggtuutgutg 660
gggucggggu tutuuttuut tguuuutttt uuttgguaut utttuuauag guuutgtgtg 720
gtutgggutu taucgagagg tuuuuaagga gagutggcgt gtuagtuagu uaagaaguaa 780
guagguaggu aatguuagua tguaggtggc ggggutggua ggggagucgg uaggaggguc 840
ggauauucgg agucggggaa utgtaatgtt uagggaattt uaattgguat tgutgtuucg 900
ttuuaguuaa utggutaacg gtgucgagtt tgaatuagtg auucguutuu tggtuuutuu 960
tuuttagucg guutututuu utuuutuutt ttttuuutuu utcggtgguu ttuuaggagg 1020
cgggaggcgu ucgutgtcga gguagutgag uuucgguaau cgutgututu cguututuuu 1080
utcgcggggu cggutuatgg agcguaggga ucgggutggu tutcgucgag uuucggguut 1140
uttttaguut cgtuuuuaga gagggaggag ucggtguucg guauaguuuc gucgguuuta 1200
<210>225
<211>1200
<212>DNA
<213>智人
<400>225
aauaattuaa aautggaagu agtuuaaaua uutattaaaa ggtagataaa uaaattgtgt 60
tatattuatg uagtggaata gtaauaguaa taaaauuuaa uaaaututtg auauatagga 120
cgaaatttat uaatuaaaat aattatguta ttggaaagaa gutagattaa atgttuatau 180
tgtatgattu tattatcgta aaattutaga aaatguaaau taatatatgg tgauagaaag 240
uagaacggga gutgggagga gtuaggtatt auaaucgggu atgaggaaau tttgaggtga 300
tggaaaagtt tatuttaatt gtggaggtga tttuaauagt gtatauatat gttuauuutt 360
aauaaattat guauttttga tatutguagt ttattgtaut ttaauuttua agutgttaaa 420
aattaaucgg agataatttt uaattgttgt gtaaggtttg uuauaaagtg taatatutgu 480
aaagaaguag auaautaatt ttttuttutt aagattgtgg aaaaagttgt aatautauag 540
agagutgtgg aatutaagga ttagttgauu aacguttgta aagutauuaa tutgaaaaau 600
auattttuag ttauuaaagt tattttutut uttuuatcgt gtaaatagaa tgtcggggtt 660
uttutaattt gggtgtttut aaaatttaaa tuuacgtgaa uagattagga aagauuacga 720
aatuutacgt uauututaaa gtuauagutt gaaguuttgc gaaaggaaut gguuutagau 780
uuuauuucgg uutataaatu auuagggcgu aguutuagtg uutgggggtc gguaguaguu 840
agcgtuaggc ggutuucgua cguttuttuu taggcgguag gucgtggutg uuacgtgaut 900
uucgutaaua ucggatgatg gcguagcgut gtguacguag gcguagtgtg ggguuuttgc 960
ggtcgaagut uacgcggtaa gucgutguac gtgtgutacg gcgggcggag ggucgaaagt 1020
uuagtatgtg ggtuuagggt uaututtuta gaguttucgu aacggaaagt gtgaggtuag 1080
tagtagtttt tgtggtacgt guagtggtgg ucguttuaag gautattttc gtcgutgutt 1140
gcgttttaag tutuuaatuu tgggacgagg uuuatttuag ggttttutgt uauuttutag 1200
<210>226
<211>1200
<212>DNA
<213>智人
<400>226
uatuutuatg tcgtgtuucg uuaguaauta taatttuuuc gcgtgautga gcguuutgut 60
agagttguuu agatttaguu agaatutggu agaggcgguu uuaaaatttg gaautuuuag 120
guutuagggg uuauututuu aguautgcgc guttggagtc ggggtggaua utgtuattut 180
ututuatcga ttgattgatt gagacgaagt utuaututgt cguuuaggut ggagtguagt 240
gggguuatut uagutuautg uaauutucgu utuucgggtt gaagcgattu ttutguutua 300
guutuutgag taautgagat uatagguauu cguuaucgcg uucggutaat tttgtatttt 360
tagtagagac ggggtttuau uatgttgguu aggutggtut uaaautuutg auutuaggtg 420
atuuauuuau utcgguutuu uaaagtgatg ggattauagg uatgaguuau agcguucggu 480
uatttutgtt gttgtttttt ttttttgaga cgaagtttua ututtgtuau uuaggutgga 540
gtguagtggu tgcgatuttg gutuautgtg auututgtut uucgggttua agcgattutu 600
utguutuagu utuutgagua gutgggauta uagguacgtg uuauuacguu cggttaattt 660
tgtttttttt tttuagtaga gacggggttt uatuatgttg guuaggutgg tuttgaautu 720
utgauutuag gtgatutguu tguutuaauu ttuuaaagtg utgggatttu aggcgtgagu 780
taucgtgutt gguutattta ttttattatt ttttaauaaa tgtuattatu ttuttaautt 840
ttgguuuuuu aaataaatga ggaaautgtt aaaattgtat tuaauaatuu ttgttcgata 900
tutuutttga tatttaaaut tttauuagtg tattaaaatg atgtutttgu attuagaagg 960
ttaaagaaat ttgtttttta aagtuaggaa guatutaaat atggtgtuut ucggaaaaaa 1020
gtattuuagg aaatutggga agucgtutgt ggaagatuag tttacgagag uutatgautt 1080
tgagautgaa gataagaaag atutgagtgg atuagaggaa gatgttattg aaggtguagt 1140
auatutuatg ttggguagtg atgtuuttua gttuatttgt tttgaauuua ttgagautat 1200
<210>227
<211>1200
<212>DNA
<213>智人
<400>227
aaaaaggutt agaggagttt gtgtgutuaa ggtuattacg ttagttaatg gagaagatag 60
gattuaaaut uagutgtuta uauaauuatu tataatgagt attutgtaaa tatttaataa 120
gtgaatttut utauauauat tguttgtatu tttgutggaa uauaaggagt guagtaaata 180
uttaaagata gtgaagtuag ggaaaguuag gaggguttgt aautaatcgu auatcgutgg 240
tgtgauuagg tgtttuaatg uuaaaguagt taaaatgtgt uttgtuaaua tuatttgaga 300
tttttagtat utattattua uttttaauua tgguttgttt tgutgttutt autgattttt 360
ttagatuuaa gauaaaataa aagaagttga guagaguaag guuacgaguu aggaautuag 420
ucgguaaatt uagaagttag utaaagauut uauaautatt utaautaagu tgaaagcgaa 480
gauagataat gtagttuaag utaaaautga uuaaaaggta agaagtagaa ttttaaaggg 540
tautautgaa tgaattaaat agtttttgga gtuagtttta uttggggata taggataaaa 600
auuttttagg aauutttttt aaaauuaaat agtaauagua ggtggtaaag aaattttgta 660
autgaaguaa uauagatuut uttauataat tgatuattat aattgaauag tattaataaa 720
tatauatgua tgagtgtgta cgaaagaaga gcgtuaaagg autaagtgat gatttaggaa 780
tauaagtata taaattuuaa autgaattgt gtuuttggta gutaaatutg tgttuttuut 840
utgttgatga gttuagggau tutaatuutt tttgggtggg guagaaggaa aatgttaguu 900
ttutuautua guutuatagg aaataaauau uaguattaua auatatuutg uuutguuttt 960
uuaaucgaag aaauaaaaat gauutgatua tagtagaatt atagtagaat tattuattat 1020
aatatttggu tttgauaaaa atuagtutga tutcgggaaa uutggagaaa tttattttut 1080
gtaututaat gttutttuat tttggtgauu atuaaggtgu tgggagagga attagatggu 1140
tgtaattuaa agttaatgga attagatgua guagtauaga aattuttgga auagaatggu 1200
<210>228
<211>1200
<212>DNA
<213>智人
<400>228
agggutgauu tggaataatt atgututggt ggttgtutuu auaaggggut utgggggtgu 60
uuuaggattg ttguuutuag guagagguag gguatauatt gagagtgatu uuaaauautu 120
utuutuuagg uuuaautttt ggaggtagua agttutguaa atagagatuu attgtttggt 180
ttutututut aaaaaaaaau aaaagtuagu auaaagaaga ggaauauatu agattggttt 240
auuagatttg tttuagatgt tattattttg auacgatuua gaagaaggag aatttgaaga 300
aaatggaaag utagguagtg ggaatgttgg uaguaggtaa gggaaaggua gguaguaaag 360
agaaauttua tutautttat aaautgutuu ttuutttuag uaaatttaga ggataaatga 420
utgttttgtt uagattggag attuaagggg gggattatta uttttaagat tattguaaua 480
tgguttcgat tattttagut guaatuatuu tgttggautt ggauttuaut gttggtgaag 540
agagautgtg tttgautttg uutggatauu ataaaauuau aauaaaataa attutuutga 600
atgutauuag guaauauuaa gatututtau auuacgagaa ggauttgtgg uuaaagatau 660
aaatggutuc guaatgtaua gggtguatau agtguauutg aagaauutaa aagtggtttt 720
tagaatuatu ataataaaua gtuaagaatt aaagatgtua agcgutttut uaagaagtut 780
aaautttata uataauatta aaaaagatut ataaaguutg auuagtutuu utuaaattaa 840
gttatttgut autgauttgg uaguuaaaac gatttaggat utttcggaag ttgatgaaaa 900
aggaguuagc gggttttgut utttgututg uatuacguuu ttuutgggau uatuagggaa 960
uutuuuaguu tttuaggata ggttucgutu agaaaggtua uucggguagt ggaaaucgtg 1020
gguaaaagtt agutgguagg auagcguagu tuutuuaggu agcggaggua gcgcgtuucg 1080
gututuaggg auatttuutt uuuauutcga uuuucgggag gtggtuucgg tataaaggut 1140
cgutgagcgg gtgggtuaua guauaguttt guagutgcgg agaaacguuu aaggucgtgu 1200
<210>229
<211>1200
<212>DNA
<213>智人
<400>229
atatttatta auatuauatt taatuttutu autgtgttau utatggggta ttuuutguau 60
ttgtttgaaa ttttutaatu aaaagggtat ttuaaaatat attgtaatat gattgattta 120
utttagatgg uaaguaaata uuautttata atagtutgua tguattuaaa gtaaaataau 180
agtagaaagu utaatututt ttguuattaa aggtttuaat ttgtuatgut uagttttaag 240
uttttaaaaa uuaauatatu uagaaaggua aaaaatauta aaatuatttu ataguagtaa 300
ttauattttu utttggatua tgtguuttta aaacgtutga atguattgut gtguaagtgt 360
uatgtgtgtt taaaagatgu ataattatta gatguagttu uaguatagtg ttttaagtau 420
aaguauuuag utuutattua aggtaagagu utttgauagg uauuaagutg uututgaatg 480
tgguagcggg atuaaattgt tgaatauatt gautuatcgg tgcgggutgg aaattatgut 540
tuttaguuut utgtgaaaua tgtttttuat tttttatttt tttttaaaut gtatuttagg 600
atutguttua aaauacggat guuuauaaaa gaguattuua tgaaatutau cggauuaggt 660
utgttaacgg gattuuagtg uuauutgatu aattagagga uatggucgag aggtaagaga 720
atatutguat ttaaaggaag tututtttta aaauautagg tggacguttt ttatatttut 780
tttatttttt uatgattttt ttttaauaga ggcguutauu tttggtaaat agaaagcggg 840
utuuuataag auatgutaag aatguuauua ttutaatgta ttattaautg aaaagagtga 900
ututgaattt atuuauaguu tagaaatuau agaaatggtt tuttuagagg utgtattttt 960
gttuagtaut gtaaggaaua ttatgtaata ttguaaaaau aguttataaa agaaauagac 1020
gagagatgtg ttgguagggg aaagaautaa atcgaagaut tuaatuattu atgutttgut 1080
tttaaatuua gagutagaaa aggaatcgga tttuuagaaa atgatuaguu agagttagaa 1140
gaguttgtgg utguattuta tttaaggutg auatgtaaua ggttaagtaa guatuagttu 1200
<210>230
<211>1200
<212>DNA
<213>智人
<400>230
attuaatgtu tuuuauttta taataguaaa tuutagautt uaggaaauag tgggutaaaa 60
agatgtatga utatuattua ttttagtuut agtttatttg utattttuut tggagtgtgg 120
tuttututut gataatuatt ttguutattu tuuuatttta aauttttuag ututuuttaa 180
ggcgguagua aataggtgaa agattgaatg aatggguagt uttuagtgaa aagaauaagg 240
aaututgtga gtggttgaut uaaatggaaa guaaagtttu tuagaatgga gauattutua 300
ttgaagaaat gatagagaag utuaagaagg tatggaatgu atggutautt aggttttuat 360
tuttuataag guttatgtgt auttttuaua ggtauagaag gtggutttau tuauaattau 420
tttuutgtua aaggaguagt atattttaaa uattttatut ttttaatata aaataaautt 480
guagutgggc guagtggutu acguutgtaa tuuuaguaut ttgggaggut gaggtgggua 540
gatuatgagg tuaggagatu aagauuatuu tgguuaauat ggtgaaauuu tgtututaut 600
aaaatauaaa auattaguut ggcgtggtgg tgcgcguutg tagtauuagu taututagag 660
gutgagguag gggaatuaut tgaauuuaga aggcggagat tguagtgagu cgagatcgtg 720
uuautguaut uuaguutggt gauagaacga gaututgtut uaaaaaaaaa aaaaaaaaaa 780
aaaaaaaaaa aggatatuua guataaaata aauttguata aaaagguutg utttauauat 840
aaaatatata gaatauttgu aatttgtgat gaaatagagu atutautatt uagttuagta 900
tttgggggtu ttaattauut gttuagtagg aauuutttat atgtattatt tttutttuut 960
tttttttttg ttttttgtgt attttttttt gttttaaaaa ggtaaaguua utagagagaa 1020
autgaaagaa aauattutta agataaattg aattgauatt ttutututaa aatatgattt 1080
atagauuaua gataggaatt aagagtttuu tgataatttt gguttuatat tattttaaag 1140
gtatgtatat uttatuaaat tattttauat attuatttgg atuuaaaaua tttutgatgt 1200
<210>231
<211>1200
<212>DNA
<213>智人
<400>231
tgauuttgtg atuuauuaau utuaguutuu uaaagtgutg ggattauagg cgtgaguuau 60
uaatgtattt uttttattaa gaaaatgtgt ttuutgtagt gttutgtttt aaaaauagtu 120
aautuauatg auuagaauua gatgutttgt tttattttag ttauaaatua tuatgtagtu 180
utttttggaa agaauttagu aaattttuat tatttattta atatttatta tttatttgtg 240
tgtagttttt aatuuuutaa aggatgtaaa guatuuagua ttaatuatat tttattgaat 300
tataggaatt aataatttgg ggauttattt tutttaaaag tataaattat taaattatua 360
tutguttagt guagaaagtt tggaaautut tgaaattuau aaaagaaaaa gagttauutg 420
aagauuuuut gaguaaatga atatagttat ttttttaatt gtuttaaaat gaaaatgtta 480
tttttgtuat utauatgatt atttttaaag gauaaaagtt ttguatatgt aagggagaat 540
aatatttutt uuttattttt uutuuuuaaa tagtutautu aaagataaag aguatgtaut 600
ttuuuauutt cguaaauaau uuutaaaaut uttguataua utaucgagut gguatautga 660
auuuaaaaaa gaaggaagtt autuuttttg utautauuat ttgutgtgtt tgtggauatt 720
ttgtttgttt guagtgggat gatttgtttt utttaaatag utttuuuagu ataauaaaut 780
guucguaaga aaagttgaut gtuuttauag aauaguagag tgtgtguagu cgatgttgtt 840
tttgutgtuu tttutttaga uutgtagutt uutuutuutt auagattaua utgagutttt 900
tuuuuttutt auautcgtgg uutauattuu aggagatuaa guutgguaua tgttaatgaa 960
tgtaggtttt atttagaaau atgauuautt gtuautguuu agtgtuatgt tatcggguag 1020
agautauuaa uatttgtuta uagtgaguat tttuatautt utatauauag auaaggggaa 1080
autttuatuu uuacguagga tatagutttt tgututguag agtutaautt ttguaagtgg 1140
aaguttuatg gtggtggcgg aggauutgag tguuutgagg atgguagagg auagutgtgt 1200
<210>232
<211>1200
<212>DNA
<213>智人
<400>232
tguuttgtut uatatttagt tuattggaat auatatatta tgutaauaat aataaguatg 60
aaaaaaattt uaaatttttt aautuuatga ggtaaautaa ataaggtaaa agaaattaaa 120
utaaggaaat tatgauaata aaatgttttg aagauttuag gttttttaaa atgttagtua 180
taatuaagaa aaaaauaaag ttguutatag tggtagattu ataauuaata tatttuttta 240
atuaaagttt aaaatatttt uatttutgat tautaaaaat auattaatat aagaagaatg 300
attgttttat aaaagaattu auagtauaat atutttaagt autatgtttt utagaattta 360
tttuttatat aaaatguagt tttutttaat tttttatttt tttttttgag attgggtttg 420
cgutgtuauu uaggutgtag tguautggtg uagtaatggu tuautguagu utuaguutuu 480
tgggutuaag uagtuttuut uuuauttuat tauutgggau tauagatgua tguuautgtg 540
uutggataat uttttgattt tttttttttt ttttttttga gatgaggtgt uautttgtaa 600
uuuaggutgg uaggtgtatt tuuttttttt tttttttttt ttttgagatg gagtutcgut 660
utgtuauuua ggutggagtg uagtggcguu atutuagutu autguaagut utguutuuua 720
ggttuacguu attutuutgu utuaguutuu cgagtagutg ggautauagg tguucguuau 780
uacguuuagu taattttttg tatttttagt agagauaggg tttuauagtg ttaguuagga 840
tggtuttgat utuutgauut tgtgatuuau uaauutuagu utuuuaaagt gutgggatta 900
uaggcgtgag uuauuaatgt atttutttta ttaagaaaat gtgtttuutg tagtgttutg 960
ttttaaaaau agtuaautua uatgauuaga auuagatgut ttgttttatt ttagttauaa 1020
atuatuatgt agtuuttttt ggaaagaaut taguaaattt tuattattta tttaatattt 1080
attatttatt tgtgtgtagt ttttaatuuu utaaaggatg taaaguatuu aguattaatu 1140
atattttatt gaattatagg aattaataat ttggggautt attttuttta aaagtataaa 1200
<210>233
<211>1200
<212>DNA
<213>智人
<400>233
tgtttgautt tguutggata uuataaaauu auaauaaaat aaattutuut gaatgutauu 60
agguaauauu aagatututt auauuacgag aaggauttgt gguuaaagat auaaatggut 120
ucguaatgta uagggtguat auagtguauu tgaagaauut aaaagtggtt tttagaatua 180
tuataataaa uagtuaagaa ttaaagatgt uaagcguttt utuaagaagt utaaauttta 240
tauataauat taaaaaagat utataaaguu tgauuagtut uuutuaaatt aagttatttg 300
utautgautt gguaguuaaa acgatttagg atutttcgga agttgatgaa aaaggaguua 360
gcgggttttg ututttgutu tguatuacgu uuttuutggg auuatuaggg aauutuuuag 420
uutttuagga taggttucgu tuagaaaggt uauucgggua gtggaaaucg tggguaaaag 480
ttagutggua ggauagcgua gutuutuuag guagcggagg uagcgcgtuu cggututuag 540
ggauatttuu ttuuuauutc gauuuucggg aggtggtuuc ggtataaagg utcgutgagc 600
gggtgggtua uaguauagut ttguagutgc ggagaaacgu uuaaggucgt guatutuuag 660
gaggtaggga aguutgcgag uutucgggtu uucguuuuua gututtuuag guaucggcgu 720
atuucggagu cgggcgcggg gcgcggggua cggagucggg gagggggtgt ggcggguuag 780
ggcggtguag ggauuutguu uagaggutga aucgguutgg gcgauuttuu ttuucgauag 840
gaguagtaga tgcgtggggg agggcgaagg gggagguutu auuuuuuagc gaguagucgg 900
gaggaggaau cggtcgcgga gggcggggag cgcggutgag uaguucggcg cgggagtgag 960
tgtgggcgag uuaguuaggg tgagcgcggg cgucgggucg cggucgucgg ucguagcggg 1020
utgagattgt tgtuututgt uauuagggcg gutgggutuu cguagtuutg uagaucgcgu 1080
ucgatuucgg cgauagggcg ggcggauagu cgcguatuuu cggggtuucg ucgaguutgg 1140
gcguagagag ucgggaggaa gcgttcgutc guttcguutt gutgutggga aautgaacga 1200
<210>234
<211>1200
<212>DNA
<213>智人
<400>234
tgttttattt tagttauaaa tuatuatgta gtuutttttg gaaagaautt aguaaatttt 60
uattatttat ttaatattta ttatttattt gtgtgtagtt tttaatuuuu taaaggatgt 120
aaaguatuua guattaatua tattttattg aattatagga attaataatt tggggautta 180
ttttutttaa aagtataaat tattaaatta tuatutgutt agtguagaaa gtttggaaau 240
tuttgaaatt uauaaaagaa aaagagttau utgaagauuu uutgaguaaa tgaatatagt 300
tattttttta attgtuttaa aatgaaaatg ttatttttgt uatutauatg attattttta 360
aaggauaaaa gttttguata tgtaagggag aataatattt uttuuttatt tttuutuuuu 420
aaatagtuta utuaaagata aagaguatgt autttuuuau uttcguaaau aauuuutaaa 480
aututtguat auautaucga gutgguatau tgaauuuaaa aaagaaggaa gttautuutt 540
ttgutautau uatttgutgt gtttgtggau attttgtttg tttguagtgg gatgatttgt 600
tttutttaaa tagutttuuu aguataauaa autguucgua agaaaagttg autgtuutta 660
uagaauagua gagtgtgtgu agucgatgtt gtttttgutg tuutttuttt agauutgtag 720
uttuutuutu uttauagatt auautgagut ttttuuuutt uttauautcg tgguutauat 780
tuuaggagat uaaguutggu auatgttaat gaatgtaggt tttatttaga aauatgauua 840
uttgtuautg uuuagtgtua tgttatcggg uagagautau uaauatttgt utauagtgag 900
uattttuata uttutataua uagauaaggg gaaautttua tuuuuacgua ggatatagut 960
ttttgututg uagagtutaa uttttguaag tggaaguttu atggtggtgg cggaggauut 1020
gagtguuutg aggatgguag aggauagutg tgtggatgua gatutuuuag attgtaautg 1080
cgatgtuaua agguagguat uttuttgagt ttuttuuatt gtauatagut ttuatgttac 1140
gtggggtttg taggatagac gutggaaguu ttaatuuaga autgtttttg uuaatgttau 1200
<210>235
<211>1200
<212>DNA
<213>智人
<400>235
ggagagauuc gaaggggagc ggaggttggg gtagaaguuu ucgguuutuu tgtattauta 60
utgcggaatg cgggggauuu cguagauagu uaggutuuua ggacggggua uuuttggggu 120
ttuagtttuu utcguatutu uaagutcgut utgcgggcga tttguuagga gaggggtuua 180
tggagagagc gggagacgag gggcguucgg utgaggaata ggguttguut uutagcgagt 240
gtcgaggtuu ucgggtucgt gcgtcggtut gtucgtucgt ttgtgtgttu tcgcggtgaa 300
cgcgggcgga uuuuuagtut utucgggaga aauttgggtu tgcggutggu acgaggtutt 360
tgtgtucggg tgtututucg gutgcgagtg gttttucgcg tutucgutgg ggggcggggg 420
auagggggcg gggtggggga gggtatgagg gtgttgcggc gtuuttuuuu uauuuuutut 480
cguuuutata autcgutuuu tucgtuuutu tcggautcgg autcgggguc ggtgcgcgau 540
tgagutggcg uututagucg autttguuaa gagggcguut uutguucgat ucgcgutgau 600
uutgcgcggg acguaguuuu aggcggutgu utagucgagg cgggaguucg agutgagtcg 660
agutcgucgg agcgggtgag tuucgaguuc gatuuucguc gggutggauu utggcgcgua 720
gutgcggcgt utucggggag tcgcgguagg gggaatggcg tgtcgcguuu tggcggcggg 780
agutgcggga gggtcggcga cgtggcgguc gguuuagggt atttauutgu tguauuagtg 840
uucgguaguu acgutcgucg gutgucgcgg gguttutttg tuucgatatu tggagggtuc 900
ggggcgggag ggagtautgg gtcgcgtuuu utuuatgggg gaggggutgg gggagtgaga 960
gguutggaga taatgcggag tgggggtggg gagatuutgu aaggauuagg acgucggggt 1020
tuuaggagau tutguaggut uuatuuutuu ttattuuuuu auuucgauuu uagtagcgut 1080
ggguutagga guautcggga gttgutuagt ggututguau cgutggcgcg ggaaggggag 1140
aaaggggutg uuagaggcgg gaatttggtu uuuacgcgut gutuuaggga cgagaaguua 1200
<210>236
<211>1200
<212>DNA
<213>智人
<400>236
gggguuuuau cgucgauagg tgtagatuaa gagautuucg agatagguuu utguagggcg 60
utggtuuuuc gguutuuutg auuatggutu auagauttuu agcgutgagt gagguagutc 120
gaaguututu agucgatutg ttuutggguu tuautuuaua gtttutgagg ggatututau 180
tttaagtuta guutuaatuu tuucgttgag utttutgtut ttuttgttat guttaguaga 240
aagatauatg atututggtg utgtttuauc gaaguaagga ggtgggtcgg cggaautgag 300
cguuutgcgu uututtgaaa tgauuuuuua ttuutgtttg uuagaaautt ttuuutuucg 360
ttguuatgga gagagacggu cgutguutuu cgtcguuata guaauatgcg ggtaucgcgg 420
aucguaggat tgcggagutc ggaaagtutt guagttcgua tcguucguut gtuttggggt 480
uttutauutu cgaagutggg autcgggggu uagtutaaut gutuucgtua ggaauutcgg 540
uuaaggtuut uuuagauuut guutgaucgt cgututttut gttacggggt tatutatttu 600
tutgtuattc gtgtgguatg tgguagttta uuuagtgttt tuauaaauac gatutttuta 660
tuuuuaggga gtucgtgaag tauttaaaat uattauauut uutttacgga gaggaaaatt 720
gaggutuaga gacguuuaag gtuauauuag guagtgaatg cggagtggga auucggautu 780
tttuutgguu ttguauuutu cgagattcgg gauaguucgg uttuucguut cgaaauuuuu 840
auuuuucgga utuagguuag tuuutgagtg tagagggggc ggucgcgagg cguuagautc 900
guuagutguc gcgggatguu acgtgagggg cggggauuut gcggggaagt gattaaaagu 960
agagcggagu cguagggggu cgutguaggg agggtuttut tggggucgtc gtguuucguu 1020
uuagtgcggu cggggcgcgg gttcgagutg utgutcggua aguutgggtg tutaggguat 1080
gagcggagtg tggggggucg gcggguutcg gtguuaggag gcgutcgcgg tuutcguutc 1140
gutgtgucgg guucggucgu uuuututcgg gutggacgtg gagauttgtc ggaguttcga 1200
<210>237
<211>1200
<212>DNA
<213>智人
<400>237
aautgggaaa gagutggaag atgagauauu aaautuuatu uuatggtgat gtttgaauua 60
ggutggagut ggtttuauat gtttttuatt gtguatgaut ttuttaattg uuttagtggg 120
aatgcgttau tguaaaataa agtgaaattg ttttuuttat tguttgtaat ttauagaggg 180
gtggttttga tuatataaau uagguauttt tuaaatuuat tgatuttagg gtggaaggag 240
ggatttuttt ttaagtattu atttcgaaut atgutttuau tagtaaautu aaaguuuaag 300
gguaaaaauu uatgattutu uattttgtaa tagutattag atgtuuauag uauatuagau 360
utgtggaaaa cguatguttt gtgtatggaa gagggagagg gagcgtuagg agttgtuutt 420
tguuaaaaaa cgtaututga uautuaaagg uauaggutgg tggagatuua gggaauucgg 480
gaaaguuuag guutaautua gguucgcgcg ggtututtut gatuuuataa gatgaggagt 540
gggtuutggu tutggguatu utggtgtcga utgtgagttu uuaguagagg uuuagagtuu 600
cggtucggua gucgagggaa gcgggggggt uttuuagaag aagaaagggu uaaggtuauu 660
ucggtguutu tuuaguagua guagagggcg gcggtcggtg tcgutgutgg ucgggguutc 720
gaggaaggcg cggguuagut ggggucgggt utgcgttuuu aggagutguu aucgttuuag 780
ggaguaagtu aggucgggac gtagcguutg cgcgggauuu tuauttguua uuaagauuuu 840
uauaaauuuc guuuuatuut guuttacguu ucguuuuaag gtcgttutuu cgauucgggg 900
tuucguuuua aggucgtuut uucguuucgu cguttggtgg cggucguatg utguucggat 960
ataaagggtc gguuuuauat uuuagggauu agcgagcggu uttgagaggu tutggututt 1020
guttuttagg cgguucgagg acguuatggu cgagtguucg auautcgggg agguagtuau 1080
cgauuauucg gaucguutgt ggguutggga gaagttcgtg tatttggacg agaaguagua 1140
cguutggutg uuuttaauua tcgaggtaua guuagutttg gagcggatgg cgagguagua 1200
<210>238
<211>1200
<212>DNA
<213>智人
<400>238
tutaatutat ggtaatcgaa atgagaagag tgtttguuuu tgguutaagg atggaaggat 60
tgatttagga aaaagtutgu aggagutttu tggagtgatg gaaatgttut aaututtttt 120
tttttuttut tuttuttutt tttuttcgtt tcgagacgga gttuuautut gucguuuaga 180
utggagtgua gtggcguuat utgggutuau tguaguutuc guutuutggg ttuaaguuat 240
tutuutguut uaguutuucg aggggutggg autauaggtg uucguuauua cguucgguta 300
attttttgtg tttttaatag agacggggtt tcguuatgtt gguuagguta gtutcgaaut 360
uutgatttua ggtgatuuau ucguuttggu utuuuaaagt gutgggatta uaggcgcgag 420
utaucgcguu uaguuaaaat gttutaattu tttattggtg gutauauagt tgtuaaaatt 480
tatuaaautg tuuauutacg atatattata aguutgtatt aaatgtaaat tagaautcga 540
ttgaaatutg tgtgtataaa tataaatata uauttattta uatttutaat utaatutgaa 600
ggtuuattgu aacgaatuuc gutucgutut gauuuaagaa utucguautt tututuuauu 660
aguutttuaa atauutgaau ttuatguutt uaagaggtgg attucggutt utttauagcg 720
uaatuautag uaggtuattt ucgtutagut tguagatttu uuattautga uauaaacgut 780
uuutuagggc gtuuucgtut ggautauagg agaaagtttg ggagguaggt tuaauttttu 840
aauttggcgg ggaattuutu tuuututtau auagtttgua gcgcgggggc ggcggggtga 900
uagtuuucgt guatgaatua guuauuuutu aggutucguu ucggcggggg tcggucggac 960
gutcguuucg uataaagcgg guauucgggu cguutggagu agaaagucgc guauutuutu 1020
ucguuaggcg utttutcgga cguuttguuu agcgggucgu ucgauuuuut guauuatgga 1080
uuucgutcgu uuuutggggu tgtcgattut gutguttttu utgacggagg utguautggg 1140
cgatgutgut uaggaguuaa uaggtatutg gucgutuuag gaguttutut uuuuaaucgg 1200
<210>239
<211>1200
<212>DNA
<213>智人
<400>239
tutaatutat ggtaatcgaa atgagaagag tgtttguuuu tgguutaagg atggaaggat 60
tgatttagga aaaagtutgu aggagutttu tggagtgatg gaaatgttut aaututtttt 120
tttttuttut tuttuttutt tttuttcgtt tcgagacgga gttuuautut gucguuuaga 180
utggagtgua gtggcguuat utgggutuau tguaguutuc guutuutggg ttuaaguuat 240
tutuutguut uaguutuucg aggggutggg autauaggtg uucguuauua cguucgguta 300
attttttgtg tttttaatag agacggggtt tcguuatgtt gguuagguta gtutcgaaut 360
uutgatttua ggtgatuuau ucguuttggu utuuuaaagt gutgggatta uaggcgcgag 420
utaucgcguu uaguuaaaat gttutaattu tttattggtg gutauauagt tgtuaaaatt 480
tatuaaautg tuuauutacg atatattata aguutgtatt aaatgtaaat tagaautcga 540
ttgaaatutg tgtgtataaa tataaatata uauttattta uatttutaat utaatutgaa 600
ggtuuattgu aacgaatuuc gutucgutut gauuuaagaa utucguautt tututuuauu 660
aguutttuaa atauutgaau ttuatguutt uaagaggtgg attucggutt utttauagcg 720
uaatuautag uaggtuattt ucgtutagut tguagatttu uuattautga uauaaacgut 780
uuutuagggc gtuuucgtut ggautauagg agaaagtttg ggagguaggt tuaauttttu 840
aauttggcgg ggaattuutu tuuututtau auagtttgua gcgcgggggc ggcggggtga 900
uagtuuucgt guatgaatua guuauuuutu aggutucguu ucggcggggg tcggucggac 960
gutcguuucg uataaagcgg guauucgggu cguutggagu agaaagucgc guauutuutu 1020
ucguuaggcg utttutcgga cguuttguuu agcgggucgu ucgauuuuut guauuatgga 1080
uuucgutcgu uuuutggggu tgtcgattut gutguttttu utgacggagg utguautggg 1140
cgatgutgut uaggaguuaa uaggtatutg gucgutuuag gaguttutut uuuuaaucgg 1200
<210>240
<211>1200
<212>DNA
<213>智人
<400>240
uuuaaattgt tutatagatt uaaaauattg uuagttaaaa tutuagtgga utttgttttt 60
ttgaaautga uaagutgatt utguuattta taataatatt uaaaggggua agaataauua 120
agauauattt gaagaagaau aaggaggaag aagaacgtat ttgaagaaga ataaggaaut 180
utattaagtg tatatutuut atatattgag atauauattt gaaatauatu tatuauutag 240
atattgagat atattataua tttaatatag tgtgttgutg gtatagggat agauaaatga 300
auattggatu agaataguau tgaaauaaga tutauuuuta tatggguatg tuuutattaa 360
uaaaaaaata ttgttgatta tttuutuaag atgatutgta aaaaauaagt taattgaaua 420
tuuatatggg aaaaaagtga atuuttutgu tauutuaaat atuaauuuua ggtagattat 480
agatutaaaa gtgaaaggua aaguaataaa gattttagaa aataauaaag agaatatutt 540
tatgaaaata uaggaaatat tttaaaaata ggutagaaaa utuautatta aaatatataa 600
aatataagaa uatutgttua tuaaaagtau tatagtttga ataguagtgt utuutuuaaa 660
attuatattg aaauttaatu uuuattgtaa uagtautaat uutaaaauta agtattaaga 720
ggtgtgauut gtgggaagtg autaagtuat gaggggtutt tuutuaggta tgggattagu 780
atuuttataa aagguuttga gatggaatgt agtguuuuut tguuututtg cgttutuuua 840
tgtgaggaua uaguaauaag guauuatutt ggaaggagag agaaguuutu auuagauaau 900
agtguauatg uuttgatutt agauttuuua guutuuagag utataataaa tauatttutg 960
ttutttataa attauttggt ututggtatt ttgttauaga aguautaatg gautaagaua 1020
aaaagattuu attatgaaag tgaaaaggua aucguagagt gguagaagut tttggagatg 1080
atgaatatgt ttauttuutg gattgcggtg atgatauuat gagtgtatau atatgtgtgt 1140
atauataatg tatauaaatt gtgttuattg attatgtaua gtttutttgt atauuaatta 1200
<210>241
<211>1200
<212>DNA
<213>智人
<400>241
gggaaagtut ggaagaauau aututtutgg atutaatuta agttttutua utauuuauut 60
atuatgagta uutttttuag tutututagg uuaagggttt uttatttaaa aggauuaaga 120
gautuuttga tuuutaagat tuutgutaag attutgtauu tutttuutuu uaaaagaatg 180
autggtuttg aattutaaaa tguaattttt gtgagtgtgt tttaaaaaga agautguatt 240
tcgutgaaaa atuttuuttg gaaagtatat aaatuttatt agacguuttt gagagtuatt 300
aaaagaautg aaguatuatg uacgtttaaa auattauuag gutggatgga gtacgaaggu 360
autuagggga aggtauttaa auutucgtag gttuaauuaa gtuttaucgg gagtaauuua 420
acgaauaagt gatguttttt gagauaaatt tggagagttg gutguaggaa aattaauaag 480
uuagtggatt tuuttttuuu ttuuttagga aauttgtttu tgtagatgua aaaaggguuu 540
tagatuutut ggaagagaaa gagagtgggg aggggaagtt tututttutt tautuuuuau 600
utgcggtutg tutgatttuu tutuuagutu tgtutgataa ggaattgatt utuuuuutuu 660
tuttuuuuut uucguuutuu ututuuttut uuutgagtaa cgatgutgtu utaguaagtg 720
atgutgtcgg agauaggaga cgggcgucga ggagguatcg ucgucgucgc ggggutggag 780
aguututuuu aguauuagag uuucgutcgg uuucgggutt uutcgtcgua guuacggucg 840
cgguagutgu tuuuacggtt tgatggtggg cggcgguagu tcgguttcgg cgutaguutu 900
taautgutgg atcgcggguc gcgacgutut ucgutuutgu uttuucguuu tgggucguuc 960
gggguuucgg aagucgcggg aggtggtgaa ggggcgucgc gggaagautg uautgucgcg 1020
aaggcggagg aggucgguag ucgguauuuu uauautcgga ucguagucgg cgcgatgtuu 1080
auuaaggtua ggaagtguaa agaauaagua agggtgauut tuucggcguc ggaggaggag 1140
gaagacgagg gcgaggacga gggcgcggag ucguagcguc gucgucgggg utggaggggu 1200
<210>242
<211>1200
<212>DNA
<213>智人
<400>242
tutuuaautu utaggutuaa utgatuutuu cgtutucguu tutuaaagtg utaggattau 60
aggtgtgagg uautgtguuu aggtgagagg taagatttut taaauagagu agaaaaauau 120
taaggtaaag gggaaaatga uaaattggua uatattaaga tgaaaaautt ttgttuttua 180
aaaggtauua ttaagatggt gaaaaagtag guuaggtacg gttgutuatg uutgtaatuu 240
uaguautttg ggagguuaag atgggcggat uauutgaggu uaggagttua gauuaguutg 300
guuaauatgg uaaaauuatg tuttgautaa aaatauaaaa uaaaauaaaa uaaaauaaau 360
aaauaaaaaa aucggguatg gtggtgggcg uutgtaatuu cggutauttg ggaggutgaa 420
guaggagaat cguttgaaut tgggaggcgg uaguttuagt gagutgagat uatguuattg 480
tautuuaguu tcggcgauag cgaaautacg agtuuaaaag aaaagtaauu uuauagagtg 540
ggaggaaata tttgtaatau utatautgga agagaaatat ttgtaatauu tatautggaa 600
gaatgautga utagtatuta guatgtauaa agguttuuta uaaatuuata tgaaaaataa 660
cgtuaguuua gtagagaaat agggagaagu utcggataut guauaagaga gaatatuuta 720
gtgguuaaua aauauatgag aaggttutua gutuattaga utttggutaa atguaaatta 780
aaauuauuat gtaatatuat tautuatuua guacgatggu taaaataaua aagacgtaaa 840
gauauuauua uagautcgcg agautgagga gtgagtgtcg cgagautgag gggtgggtgt 900
cgcgagautg aagagtgggc ggcguaaatg ggcgaggtgt ttautcguua ttttgtgtga 960
ggaacgttga cgutauutau ututgguutg guututauuu autgutguuu tggucgutau 1020
uaauatgagu utuucggaga gtuutuauag uuucgutaut utcgautatg ututggaaga 1080
uucguauuag gguuagaggt uucgagaaaa gaguaaggcg auagaggtaa tgguagatat 1140
gtttgatggu cguttggagu uaatcgtgtt uuuaucguuu cgguttuuag aggagggggt 1200
<210>243
<211>1200
<212>DNA
<213>智人
<400>243
atutgttaau utuaauttuu taaatagaag gtutattutt ttauuatuat uattattutu 60
ttcggtguut atttttaaaa aatautuaau uttuttgutt uuttcgutau utaagtattt 120
utguaaguuu autttgttut guaguttagu tttuutggua uaattuttat agattttggt 180
uuuttttaaa attuattutt uaguaaatgu tttutututu uatuttttga utagagatua 240
ttagagatua uutgagatua ttagagaaua gtggtttuut tggttguuat tuuutttutt 300
uttuattggg agtattutgc ggtgaautua gauattttat ttttuaaagu ttuuuattut 360
tttaaaaatg uttttuuttt tauaguutut cgutuaaaat uatauuuatu ttttuuutgg 420
atutgttttu tuaagtutuu aatcguutgu uttutttgtg tuttgtatta uuutuauatu 480
uuuuaguttt utautgutut uuuaggauua auuatttutt ucgcgggagt uauattauat 540
uaguattuut aatguagtat utgttatuta uuagattutg ttttattuta ggtagtuaut 600
taaaaacgaa uutcggtaut ggtutgautt aauatggagg aggaattgtu taaggttaaa 660
cguaaautgu tgagagattt ggggcggggg guauauattt auattuattc gtattaaata 720
tatauutgtt gaatttgtgu tttttutuaa atguttuaga gautcgagut ttagagtaat 780
tgggatggtg aaaggatggg tttuuagaaa uttcguuuaa aattaaagau tuuatuaaaa 840
ggautgutuu atauautuaa ggaauauuua uuaauaaatu ucgtutuuau aauuauuaga 900
ttatutuauc ggcgagtgag autguaaggt ttggggguuc ggucgtauua utucgcgutg 960
cguacggggg gttcgtauuu atutggucgc gaucgtucgt ttuuuuutcg uttggttutg 1020
uuuutgutuu uuutguauag guutuauagt gcgtutgguc ggcgutttat agutguaguu 1080
tgggcggutu cgutagutgt ttttcgtutt uuutagguta tttutgucgg gcgutucgcg 1140
aagatguagu tuaagucgat ggagatuaau uucgaggtga gcguuaggtg uaucgutauu 1200
<210>244
<211>1200
<212>DNA
<213>智人
<400>244
aaaatautua auuttuttgu ttuuttcgut auutaagtat ttutguaagu uuautttgtt 60
utguagutta gutttuutgg uauaattutt atagattttg gtuuutttta aaattuattu 120
ttuaguaaat gutttututu tuuatutttt gautagagat uattagagat uauutgagat 180
uattagagaa uagtggtttu uttggttguu attuuutttu ttuttuattg ggagtattut 240
gcggtgaaut uagauatttt atttttuaaa guttuuuatt uttttaaaaa tguttttuut 300
tttauaguut utcgutuaaa atuatauuua tuttttuuut ggatutgttt tutuaagtut 360
uuaatcguut guuttutttg tgtuttgtat tauuutuaua tuuuuuagut ttutautgut 420
utuuuaggau uaauuatttu ttucgcggga gtuauattau atuaguattu utaatguagt 480
atutgttatu tauuagattu tgttttattu taggtagtua uttaaaaacg aauutcggta 540
utggtutgau ttaauatgga ggaggaattg tutaaggtta aacguaaaut gutgagagat 600
ttggggcggg ggguauauat ttauattuat tcgtattaaa tatatauutg ttgaatttgt 660
gutttttutu aaatguttua gagautcgag utttagagta attgggatgg tgaaaggatg 720
ggtttuuaga aauttcguuu aaaattaaag autuuatuaa aaggautgut uuatauautu 780
aaggaauauu uauuaauaaa tuucgtutuu auaauuauua gattatutua ucggcgagtg 840
agautguaag gtttgggggu ucggucgtau uautucgcgu tgcguacggg gggttcgtau 900
uuatutgguc gcgaucgtuc gtttuuuuut cguttggttu tguuuutgut uuuuutguau 960
agguutuaua gtgcgtutgg ucggcguttt atagutguag uutgggcggu tucgutagut 1020
gtttttcgtu ttuuutaggu tatttutguc gggcgutucg cgaagatgua gutuaagucg 1080
atggagatua auuucgaggt gagcguuagg tguaucguta uucggagagc gcgaggucga 1140
gggaggggga gucgagtcgu tgatcggttc ggttttguut ttttutttgu atttguuttt 1200
<210>245
<211>1200
<212>DNA
<213>智人
<400>245
aaatautuaa uuttuttgut tuuttcguta uutaagtatt tutguaaguu uautttgttu 60
tguaguttag utttuutggu auaattutta tagattttgg tuuuttttaa aattuattut 120
tuaguaaatg utttututut uuatuttttg autagagatu attagagatu auutgagatu 180
attagagaau agtggtttuu ttggttguua ttuuutttut tuttuattgg gagtattutg 240
cggtgaautu agauatttta tttttuaaag uttuuuattu ttttaaaaat guttttuutt 300
ttauaguutu tcgutuaaaa tuatauuuat uttttuuutg gatutgtttt utuaagtutu 360
uaatcguutg uuttutttgt gtuttgtatt auuutuauat uuuuuagutt tutautgutu 420
tuuuaggauu aauuatttut tucgcgggag tuauattaua tuaguattuu taatguagta 480
tutgttatut auuagattut gttttattut aggtagtuau ttaaaaacga auutcggtau 540
tggtutgaut taauatggag gaggaattgt utaaggttaa acguaaautg utgagagatt 600
tggggcgggg gguauauatt tauattuatt cgtattaaat atatauutgt tgaatttgtg 660
utttttutua aatguttuag agautcgagu tttagagtaa ttgggatggt gaaaggatgg 720
gtttuuagaa auttcguuua aaattaaaga utuuatuaaa aggautgutu uatauautua 780
aggaauauuu auuaauaaat uucgtutuua uaauuauuag attatutuau cggcgagtga 840
gautguaagg tttggggguu cggucgtauu autucgcgut gcguacgggg ggttcgtauu 900
uatutggucg cgaucgtucg tttuuuuutc guttggttut guuuutgutu uuuutguaua 960
gguutuauag tgcgtutggu cggcguttta tagutguagu utgggcggut ucgutagutg 1020
tttttcgtut tuuutaggut atttutgucg ggcgutucgc gaagatguag utuaagucga 1080
tggagatuaa uuucgaggtg agcguuaggt guaucgutau ucggagagcg cgaggucgag 1140
ggagggggag ucgagtcgut gatcggttcg gttttguutt tttutttgua tttguutttu 1200
<210>246
<211>1200
<212>DNA
<213>智人
<400>246
tguttuuttc gutauutaag tatttutgua aguuuauttt gttutguagu ttagutttuu 60
tgguauaatt uttatagatt ttggtuuutt ttaaaattua ttuttuagua aatgutttut 120
ututuuatut tttgautaga gatuattaga gatuauutga gatuattaga gaauagtggt 180
ttuuttggtt guuattuuut ttuttuttua ttgggagtat tutgcggtga autuagauat 240
tttatttttu aaaguttuuu attuttttaa aaatgutttt uuttttauag uututcgutu 300
aaaatuatau uuatuttttu uutggatutg ttttutuaag tutuuaatcg uutguuttut 360
ttgtgtuttg tattauuutu auatuuuuua gutttutaut gututuuuag gauuaauuat 420
ttuttucgcg ggagtuauat tauatuagua ttuutaatgu agtatutgtt atutauuaga 480
ttutgtttta ttutaggtag tuauttaaaa acgaauutcg gtautggtut gauttaauat 540
ggaggaggaa ttgtutaagg ttaaacguaa autgutgaga gatttggggc gggggguaua 600
uatttauatt uattcgtatt aaatatatau utgttgaatt tgtguttttt utuaaatgut 660
tuagagautc gagutttaga gtaattggga tggtgaaagg atgggtttuu agaaauttcg 720
uuuaaaatta aagautuuat uaaaaggaut gutuuataua utuaaggaau auuuauuaau 780
aaatuucgtu tuuauaauua uuagattatu tuaucggcga gtgagautgu aaggtttggg 840
gguucggucg tauuautucg cgutgcguac ggggggttcg tauuuatutg gucgcgaucg 900
tucgtttuuu uutcguttgg ttutguuuut gutuuuuutg uauagguutu auagtgcgtu 960
tggucggcgu tttatagutg uaguutgggc ggutucguta gutgtttttc gtuttuuuta 1020
ggutatttut gucgggcgut ucgcgaagat guagutuaag ucgatggaga tuaauuucga 1080
ggtgagcguu aggtguaucg utauucggag agcgcgaggu cgagggaggg ggagucgagt 1140
cgutgatcgg ttcggttttg uutttttutt tguatttguu tttuagatgu tgaauaaagt 1200
<210>247
<211>1200
<212>DNA
<213>智人
<400>247
uuuuagtuta gaaagaauut ggcgtgtagu aggatguaau at atauttgt agaatgaata 60
aaaaggtaat aaaataauac gagutuauat agcgguuagu atttgutgtg uauuataatu 120
cgtgutaagu autttguatg cgttatttaa tttgaatttu ataauagtat tauataagaa 180
aauaataggg uuagguatgg tggutuacgu utgtaatuuu aguautttgg gaggucgagg 240
uaggcggatu acgaagtcgg gagutuuaga uuaguutgau uaauatggtg aaauuuuatt 300
tutautaaaa utagaaaaag taguuaggcg tggtggcgtg cguutgtaat uuuagutaut 360
tgggaggutg agguaggaga attguttgaa uucgggaggt ggaggttgua atgagutaag 420
attguauuau tguautuuag uutgggcgau agagtgagau tucgtutuua aaaaaaaaga 480
agaaaaagaa aagauagtat tttgutuuut uaucguuttu agguttttaa uuaautguua 540
uttauuauuu tagtgaaggt ttguucgagt guuutattta atattguagg uttutgtttu 600
utauuaguuu utttguttau tutttuauau ttagtuauut tutaacgtgg uatauattgu 660
ttattttuta tgutuatgag tatgtutaut uuatggaggu atagatgttt gtatguutgt 720
ttautgatgg atuauaaaut gtgtaguuta aaatagagut aguauatagt uuuauuuaau 780
acgtgtuagg tgaguaatta gatatagagg gttuuaataa uttgtgggga uauuuagata 840
agatutgttt atgautuatg tuttauauag agutuattut tggtututtg gttagtttat 900
uagagaagau aaatgtatta ttggaaaatg tgtuttaggt uattttttga uagtggutut 960
aatautggaa tutattttaa utaaaggtta ttatuataaa guaggtgttt gutgaagaua 1020
guttautuag atuautautg uutggaggtg gttgatatat uutggtgtaa auuttuaaga 1080
aggguauagg uaggaaaaua tgaguuagua autgaagaaa cggguaaaga uaagauauua 1140
gaaagguutg ggtggaagag uuuuuagtgg ggutaaguuu agguaaggua agtuaaguua 1200
<210>248
<211>1200
<212>DNA
<213>智人
<400>248
uutagutuuu utttutgtua gttttttaat tttatatttg ttttuaaatg agtuutuaua 60
ttgattttaa aaatttaaua agagtatagt gaaaaggaag ttuuuutttu autatttatu 120
ttuuuuatat guatutatta tgacgggttt uttttttaaa utauttggag tautuataau 180
tgattttgta ututagttua gaagaaatgt utgaatgtta aatgtttaua taaaaaatgu 240
tattttatta tatuagtaat ggaguttuuu uuutttaaaa utgutguauu aggaagatau 300
aauuttgtta tuauaattta aagagaaaat gagauttgga ggttuagatt uutuuauagt 360
uatagtatua gutauuuacg uagtgauuua uattuaggtg attauauaua utuatauaua 420
gatuuataua cgatuttguu uuuuuuauut uuauauautu aatatgauut uuuuacguuu 480
aaagutguau auatuttgau utuauttutu tuauauauau auuaatutga uucguacgcg 540
gtttutttua utuaautauu uagauauuuu tuatuuuauu aguauaagua gguuuaucgc 600
ggtutuauau auautcgagu uttuutttgu uuagtutuau atguatgaut gggatcgcgg 660
atttgtuuuu ttucgautuu uuatgutggt tcggtuuuag acgutuaggt guuauattgg 720
ggtgcgutut uucggutuut uuauacguta cguagutguu cguutuaaga gcgtutgcgt 780
guttuuagcg ttaagtggaa ttuuaaguag uutucggggu auagttagtu tggtuautgc 840
gguuagautg ucguutuagg auuuagagaa cguaguauau tttagttggg uuuatutatu 900
uucggcgagg uttggautac gtttuuuagg agauuutgcg gtuuagtatg tutuucgagg 960
aggggcggaa guucgggagu cguuututga ggutgggcgg ggtgaaagaa aguttguuuu 1020
agaggautta aauagguaag aaggauttgg ttaaagauta ttguaatagt uaauttuuaa 1080
tauaauagua gutggagatt tatagutaac gggutgggtg aaggagttaa aggatgutaa 1140
attautaaga ggaagttaag tatuaagagt ggggggattg ttautaaaut gguttagutg 1200
<210>249
<211>1200
<212>DNA
<213>智人
<400>249
auattguutu utgtuttgtu ttuuutttuu tuttatgtta aaauuagatt utgttuutut 60
gutgtaguuu ttautgagut uuatuttutu tuaatgttat uatuatagaa tttggaggua 120
aauttatttu ttaaatggua taaauaaauu auattutaau uauagatgaa tuttuuutut 180
uuatagutua ttuuatautu atttaguaua ttagtutttu attgggaaau tgututttgt 240
ggattatutt tuttttutgt ututatuagt ttatatguaa attatgttta ttautgaaau 300
atuuuagatt tuuuauuuua ggaaaaatgt agtautuuua auaauuutga taaatgaata 360
tgagaattau tutuatttat aaatgtttat aguautagat tuatututta aaaaattaag 420
auaggguuag gauatutgta taattauuaa gutttuaaag tutguaggau ttttaaauta 480
aautaaauta utatttaaaa utautatttt aaataaatat utaaautaut atttaaaaat 540
aatutgtttu utgaaaauut uutuuauttt utagtutgau ttttautuat tttututgut 600
tuuutaatut gtttttuaaa ttguuuagtu atatgtgaga autgtataaa uuautuaatt 660
tttatgaaaa ttaaattgta gttaagtutt tcgtatutat tataaacgtt taatututuu 720
uagaauauaa aaaagtgaat gtttgutttt atattttutt tuagautatg aatuaaagtt 780
gagauuaaga aattatttut gaaaaaggat atggaaaauu ttauaaaaua uaguattgag 840
tgttuaagtt tuagaggtga ttgggaatgt aaaaauuagt ttgagagaaa auagggatut 900
uaggaaggau atttuagtga aatgatattt autuutgaag auatguuuau tttuagtatu 960
uaguatuaga gaattuatau tgatgagaaa utuuttgaat gtaaggaatg tgggaaggat 1020
tttagttttg tatuagtuut tgttcgauat uagcgaattu atautggtga gaaauuttat 1080
gaatguaaag aatgtgguaa gguutttggt agtggtguaa auuttgutta uuatuaaaga 1140
attuatautg gtgagaaguu ttttgaatgt aaagaatgtg ggaagguutt tggtagtggu 1200
<210>250
<211>1200
<212>DNA
<213>智人
<400>250
ggucgttatg aagaggaaga agtautgtgt uatutattgt uutggggauu tgtuaauagg 60
aauaatagat agauatuauu aggggtgtat ttutgttuaa uauaaggaaa agtttutaat 120
tggagutgtu uaguatgaaa tggautaagu agtguatttt utttutucga tuutgautuu 180
autgtgacgg guautguaga utagagagat tgtgtuutag tatgaattta ggttggataa 240
atgatautta gggataaaga gaggaaagga atatuagaat utuuaagaag utgatauatt 300
ttgaaaaaat atataaaatg uuauauttua ggttttuttg tgtttaattt gaaacgtuua 360
gtaauattaa agaauaguat ttgatttgut taaauaaagt agtaauagut gaagttuutt 420
uuaaatuaut tttutgattu tutaagaggu ttguutatgu uttguagatu taguttuauu 480
tauaagauat attutgtaag gatuuaggtt uaguaaggtg tuagaatgtu utaagggttt 540
utgtuucggc gututguutg tuucguttgt guauaatgut tttguutatu uutgtttutg 600
uatagatttt agtuttuuua uuagggacgu aautgtuagt ttuutucgtu tututcggtt 660
utattuuaat utgutuatut uuuutuucgt uuucgutttu uuuaaggauu tautgagatt 720
tcgatuuuau aauttagtgg gtuuuatutu auuuagguuu cguaatuutc guuttutaut 780
tgtuagcgtt gtautauaut utgaguaggu auuuutgtgu tautuacgga agcgggauua 840
ttaggtcggu uattuutuut uauuuuacga uacguauuua utgggtcggg ucguutuutt 900
guagggagtu tuaaggatgg gutggcgtua gggagggguu uagggggcgu tttuuuaaua 960
utggtcguag tuattgttgg tataacggut agagacguuu agtgagttag uatggagggu 1020
agtgggaucg gaaaaagacg tggaaaagut gcgaaaacga guuttcgaat uatggacgcg 1080
cggguuuagu tuutuutucg agttuutuat ucggggucgt uautuauatu cgggguuutu 1140
autuauatuc gggauuutua tucggggutu tuauuuauat ucgggauuut uatguutggg 1200
[03]制造所有活生物的细胞的信息包含在它们的DNA中。DNA是由四个碱 基的独特序列组成，四个碱基为：腺嘌呤(A)、鸟嘌呤(G)、胸腺嘧啶(T) 和胞嘧啶(C)。在形成DNA双螺旋的两条链上，这些碱基A与T和G与C配 对。这些碱基对的链存储制造分组成被称为基因的区域的具体分子的信息。在每 一个细胞里面，具有控制什么基因被开启或表达的程序，从而确定每个细胞的独 特功能。这些控制机制之一是通过将甲基加到胞嘧啶(C)上而提供。甲基标记的 C可以写成mC。
[04]DNA甲基化在确定是否一些基因被表达或者不被表达中起到重要的作 用。通过关闭不需要的基因，DNA甲基化是生物体正常发育和发挥功能的必不可 少的控制机制。可选地，异常的DNA甲基化是引起随着老化和多种癌症的发生而 观察到的变化的机制之一。
[05]癌症在过去与在DNA内由染色体突变引起的基因变化联系起来。突变— —遗传性的或获得性的——可以导致对于维持健康状态至关重要的基因表达的丧 失。现在证据支持，相当大数量的癌症由不适宜的DNA甲基化，频繁接近的DNA 突变所引起。在许多情况下，DNA的过度甲基化不正确地关闭至关重要的基因例 如肿瘤抑制基因或者DNA修复基因，从而使得癌症能够发生和进展。这种控制基 因表达的非突变过程被描述为外因遗传学(或表观遗传学，epigenetics)。
[06]DNA甲基化是通过称为甲基转移酶的酶来进行的DNA化学修饰，在其 中甲基基团(m)被加到DNA的某些胞嘧啶(C)。这种非突变的(外遗传的) 过程(mC)是基因表达调控中的关键因素，参见J.G.Herman，Seminars in Cancer Biology，9：359-67，1999。
[07]虽然基因甲基化的现象已经引起癌症研究者的注意有一段时间，但是它 在人的癌症发展中的真正作用刚被认识到。在正常的细胞中，甲基化主要发生在 具有很少CG碱基重复的DNA区域中，而CpG岛，具有长CG碱基重复的DNA 区域，仍然保持非(未)甲基化。控制蛋白表达的基因启动子区域通常是富含CpG 岛的。在启动子区域中这些正常的非甲基化CpG岛的异常甲基化导致在人癌症中 某些肿瘤抑制基因表达的转录失活或者沉默。
[08]在肿瘤细胞中的过度甲基化的基因对于肿瘤来源的组织是非常特异的。 所有类型癌症的分子特征可以用于改进癌症的检测、癌症风险的评估和对治疗的 反应。启动子过度甲基化事件为这些目的提供了一些最有希望的标记。
启动子基因过度甲基化：有希望的肿瘤标记
[09]关于特定启动子基因的过度甲基化的信息可以有益于各种癌症的诊断、 预后和治疗。特定基因启动子区域的甲基化可以在早期和经常在癌发生中出现， 使得这些标记成为癌症诊断的理想靶标。
[10]甲基化模式是肿瘤特异的。阳性信号总是在基因的相同位置被发现。实 时PCR为基础的方法是高度灵敏的、定量的和适合于临床使用。DNA是稳定的 和发现在容易获得的流体(例如血清、痰、粪便、血液和尿)和石蜡包埋组织中 是完整的。一系列有关的基因标记可以覆盖大多数人类癌症。
诊断
[11]改善在癌症患者中的临床结果的关键是在癌症的最早阶段的诊断，在此 期间癌症仍然是局部的和容易治疗的。上文提到的特征通过在分子基础上鉴定较 高风险患者提供了更准确地筛查和监测计划的手段。它也为对患者进行更明确的 随访(follow up)提供了理由，所述患者具有与恶性病相关的分子特征，但是还没 有与恶性病相关的所有病理或者临床特征。
[12]在目前，结肠直肠癌的早期检测是通过以下几种方法来进行的：(1)“粪 便潜血试验”(FOBT)，它具有非常低的灵敏度和特异性，(2)乙状结肠镜检查 和/或结肠镜检查，它具有侵入性并且是昂贵的(以及供应有限)，(3)在双重对比 钡餐灌肠后的X射线检查，其仅允许检查相当大的息肉，或者CT-结肠镜检查(也 被称为虚拟结肠镜检查)，它仍然是实验性的，和(4)称为PreGen-Plus的基因 突变分析试验(Exact Sciences；LabCorp)，它是昂贵的且灵敏度有限。
预测治疗反应
[13]关于癌症如何通过分子事件发展的信息将使得临床医生能够更准确地预 测这种癌症对特定的化疗剂可能怎样反应。这样，根据肿瘤的化学敏感性的知识 可以理性地设计治疗方案(regimen)。研究已经显示，在神经胶质瘤患者中的 MGMT启动子的过度甲基化表明对治疗的良好反应、更大的总生存率和进展需要 更长时间。
[14]现在充分确立了，在人的癌症中正确基因功能的丧失可以通过遗传和外 遗传机制来发生(1、2)。在人的肿瘤样品中突变基因的数量正在被阐明。最近， 等(3)测序了在结肠直肠癌(CRC)和乳腺癌中的13,023个基因，发现 每个肿瘤平均11个突变，这提示了相对少量的遗传事件可能足够促使肿瘤发生。 相比之下，外遗传改变的整个图谱没有被充分描述。最详细说明的癌基因外遗传 学改变涉及在与受影响基因的转录失活相关的启动子区域中，成簇的CpG二核苷 酸或者CpG岛的DNA过度甲基化。这些启动子接近所有基因的几乎一半而定位 (4)，并且认为这些启动子在正常的体细胞组织中基本上保持无甲基化。在任何 特定的肿瘤中的这种外遗传损害的精确数量不是准确已知的，虽然不断增加数量 的随机筛查方法正在鉴定不断增加数量的候选基因(5-12)，但是这些方法中没有 一个方法有效覆盖全基因组。考虑到在基因组中存在大量潜在目标启动子，我们 假定还有很多过度甲基化的基因等待发现(13)。
[15]在本领域中有对改善患者护理管理的针对癌症的新的诊断和预后标记以 及治疗靶标的持续的需求。
发明概述
[16]依照本发明的一方面，提供鉴定结肠直肠癌或者它的前体、或结肠直肠癌 倾向的方法。在含有结肠直肠细胞或者来自结肠直肠细胞的核酸的试样中检测外 遗传沉默。外遗传沉默是选自以下的至少一个基因：BOLL、CABYR、EFEMP1、 FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、 TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、 CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、 DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、 SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、 EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、 PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、 CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、 ZNF345、DKK3和ZNF655。当外遗传沉默被检测到时，试样被鉴定为含有细胞， 所述细胞是瘤性的(增殖性的)、瘤的前体、或易于形成瘤，或者鉴定为含有来自 细胞的核酸，所述细胞是瘤性的、瘤的前体、或易于形成瘤。
[17]依照本发明的另一个方面，提供了减少或者抑制细胞瘤性(增殖性)生 长的方法，所述细胞显示了与癌症相关的至少一种基因的外遗传沉默的转录。外 遗传沉默的基因在细胞中被确定。所述基因选自BOLL、CABYR、EFEMP1、 FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、 TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、 CD109、LGR6、RET、CHD5、RNF 182、ICAM5、ARMCX2、CBR1、DDX43、 DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、 SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、 EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、 PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、 CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、 ZNF345、DKK3和ZNF655。通过将细胞与一种或者多种试剂接触恢复外遗传沉 默基因编码多肽在细胞中的表达，所述试剂选自：CpG二核苷酸脱甲基剂、DNA 甲基转移酶抑制剂和组蛋白脱乙酰酶(HDAC)抑制剂。不受调节的细胞生长因而 被减少或者抑制。
[18]本发明的另一方面是减少或抑制细胞的瘤性生长，该细胞显示了与癌症 相关的至少一种基因的外遗传沉默转录。外遗传沉默基因在细胞中被确定。所述 基因选自BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、 Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、 MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF 182、ICAM5、 ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、 NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、 ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、 LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、 CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、 TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。编码多肽的多核苷酸被引入到细 胞中。多肽被所述基因表达。多肽在细胞中被表达，因而恢复多肽在细胞中的表 达。
[19]本发明的还另一方面是治疗癌症患者的方法。患者的癌细胞被确定具有 选自以下的外遗传沉默的基因：BOLL、CABYR、EFEMP1、FBLN2、F0XL2、 GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、 SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、 RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、 HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、 TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、 FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、 REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、 RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。 一种或者多种选自CpG二核苷酸脱甲基剂、DNA甲基转移酶抑制剂和组蛋白脱乙 酰酶(HDAC)抑制剂的试剂以足够量给予患者，以恢复在患者的癌细胞中外遗传 沉默基因的表达。
[20]本发明的还另一方面是治疗癌症患者的方法。患者的癌细胞被确定具有 选自在以下显示的外遗传沉默的基因：BOLL、CABYR、EFEMP1、FBLN2、FOXL2、 GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、 SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、 RET、CHD5、RNF 182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、 HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、 TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、 FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、 REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、 RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。 编码多肽的多核苷酸被给予患者。多肽由外遗传沉默的基因编码。多肽在患者的 肿瘤中进行表达，从而恢复多肽在癌症中的表达。
[21]依照本发明的另一方面，提供了选择治疗癌症患者的治疗策略的方法。 基因被鉴定，该基因在患者癌细胞中的表达通过CpG二核苷酸脱甲基剂、DNA甲 基转移酶抑制剂或者组蛋白脱乙酰酶(HDAC)抑制剂再激活。基因选自BOLL、 CABYR、EFEMP1、FBLN2、F0XL2、GNB4、GSTM3、HoxD1、Jph3、神经化 (NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、 EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、 CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、 SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、 ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、 MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、 CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、 TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。为癌症患者选择治疗剂，该治疗 剂增加基因的表达，用于治疗所述癌症患者。
[22]本发明的另一个实施方式是评估试样中甲基化的试剂盒。试剂盒包括至 少以下试剂：(a)修饰甲基化的胞嘧啶残基、但不修饰非甲基化的胞嘧啶残基的 试剂，或者(b)修饰非甲基化的胞嘧啶残基、但不修饰甲基化的胞嘧啶残基的试 剂；和一对寡核苷酸引物，其在扩增条件下与大约1kb的所述基因转录起始位点 内的基因区域特异性杂交，所述基因选自BOLL、CABYR、EFEMP1、FBLN2、 FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、 RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、 LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、 FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、 TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、 FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、 RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、 MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3 和ZNF655中显示的基因。
附图简述和表格
[23]图1A-1E.在HCT116CRC细胞中鉴定人癌细胞的过度甲基化组 (hypermethylome)的方法。(图1A)来自标示细胞系的RNA被分离、标记、杂 交、扫描，以及荧光点强度通过减去背景来归一化和使用Agilent Technologies 44K 人微阵列进行黄土转变(Loess transformation)。在我们的研究中比较了亲本野生 型HCT116细胞(WT)和DNA甲基转移酶1(DNMT1-/-)或者3b(DNMT3b-/-) 的同基因敲除对应物。DKO细胞对于DNMT1和DNMT3b是双重缺陷的。(图 1B)在具有各种DNA甲基转移酶的遗传中断的HCT116细胞中，基因表达变化。 三维散布图以对数单位指出了在HCT116细胞中的基因表达水平，所述细胞具有 DNMTs 1(X轴)、3b(Z轴)和两种DNMT(DKO；Y轴)的遗传中断。对于 DKO细胞中具有大于4倍表达变化的那些基因，单个基因表达的变化为黑色，对 三个实验的平均值(红色点)或者来自单个实验(蓝色点)。(图1C)HCT116细 胞用300nM曲古柳菌素A(TSA)处理18小时或者用5μM的5-脱氧氮杂胞苷 (DAC)处理96小时，如前所述处理。(图1D)对于用TSA(X轴)或者DAC (Y轴)处理的HCT116细胞的基因表达变化通过倍数变化来绘图。黄色点指出 来自DKO细胞具有2倍和2倍以上变化的基因。当与在DKO细胞中看到的基因 表达增加比较时(在DKO细胞中大于2倍现在变成了在DAC处理的细胞中大于 1.3倍)，注意到敏感性的丧失。绿色点指出了随机选择的基因，其已被证实在野 生型细胞中具有完整的启动子甲基化、在DKO细胞中和在AZA处理后的重新表 达，而红色点指出了经鉴定为假阳性的选择基因(参见确认结果的图5(S2))。 蓝色点指出了11种引导基因的位置——这11种引导基因在先前表现为过度甲基 化的和在这个研究中使用的HCT 116细胞中为完全沉默的(参见图4(S1)的描 述)。包括11种引导基因中的5种的独特组的基因显示了在用DAC处理后大于2 倍的增加、而用TSA处理后没有增加。这些基因形成了在文本中讨论的候选过度 甲基化基因的顶部列。(图1E)通过树状图分析来鉴定全转录物组表达型的关联 性。DNMT1和3b、DKO的个体单个遗传中断以及DAC处理和TSA处理各自形 成三个不同类别的基因表达变化。
[24]图2A-2C.在不同的人CRC细胞系中表征人癌细胞过度甲基化组。(图 2.A)用TSA(X轴)或者DAC(Y轴)处理的指示细胞的基因表达变化通过倍数 变化来绘图，单个基因用黑色来显示。(图2B)DNA过度甲基化组的确认。由用 DAC或者TSA处理细胞来限定的过度甲基化基因的特有峰(spike)由2个具有不 同特征的层组成。上层基因鉴定为这样的区域，在该区域中，基因表达不随着TSA 增加(＜1.4倍)，并且在野生型细胞中没有显示出可检测的表达，但是用DAC处 理后有大于2倍的增加。下层的基因被鉴定为一组基因，其表达变化与在上层中 的相同、但是用DAC处理增加1.4倍至2倍之间。通过RT-PCR和MSP确认基因 表达，表明在HCT116细胞中上层基因86％的确认频率，包括在DKO细胞中增加 2倍以上的基因。在HCT116细胞中下层基因被确认在49％的频率，和在SW480 上层中具有65％的频率。(图2C)在CRC细胞系中共有的候选过度甲基化基因。 我们鉴定了在所有6个细胞系中具有落入上层或者下层类别标准的表达变化的总 共5,906个基因。指出了在2、3、4、5或者6细胞系当中基因表达变化的重叠； 这些的范围从2个细胞系中共有的1414个基因，到6个细胞系中共有的78个基 因。
[25]图3A-3E.在人肿瘤样品中过度甲基化和基因突变频率的比较。(图3A) 在人组织样品中验证的过度甲基化组基因的甲基化分析。来自验证的基因清单的 二十种基因从HCT116上层(BOLL、DDX43、DKK3、FOXL2、HoxD1、JPH3、 Nef、神经化的、PPP1R14a、RAB32、STK31、TLR2)、HCT116下层(SalL4、 TP53AP1)或者SW480上层(ZFP42)中随机地选择，并且分析在CRC细胞系(白 色柱)、正常结肠(红色柱)或者原发性肿瘤(绿色柱)中的甲基化。甲基化的 百分比在Y轴上示出，和缩写的基因名称在X轴上。我们测试了至少6种不同的 细胞系、来自非癌症患者的16到40个结肠样品和18到61个之间的原发性CRC 样品的每种基因。(图3B)CAN基因的甲基化分析。56种基因鉴定为重叠了过 度甲基化组和CAN基因列单，包括含有CpG岛的45种基因。来自这个列单的、 在细胞系中具有甲基化的选择的基因(26种基因)，被在分析在正常结肠(图3B) 和原发性CRC(图3C)中的甲基化。这些基因的甲基化频率以百分比显示。(图 3D)重叠了CAN和过度甲基化组基因列单的13种基因的甲基化和突变之间的关 系。(图3E)在人癌症中基因失活机制的模型。
[26]图4A-D.(S1).在这个研究中使用的引导基因。(图4A)先前显示在 HCT116细胞中被过度甲基化和完全沉默的11种引导基因的基因名称、Agilent Technologies探针名称、Genbank登录号和参考。(图4B)蓝色点和基因名称指出 在TSA(X轴)对DAC(Y轴)基因表达变化图中或者在(图4C)DKO(X轴) 对单个敲除(Y轴)基因表达变化的图中的11种引导基因的位置，以对数表示。 用绿色圈出的11种引导基因中的5种在用AZA处理后显示了大于2倍的增加， 但是用TSA处理后没有增加，这些同样的基因并且在DKO细胞中(绿色圆圈) 中有大于3倍的增加。(图4D)在DKO和DAC图中引导基因的直接比较。由绿 色圆圈示出的不同组的5种引导基因限定了如在本文中所讨论的候选过度甲基化 基因的上层，5种引导基因在DKO细胞中显示出大于3倍的表达变化和在DAC 处理的细胞中显示出大于2倍的表达变化。在用DAC处理后增加1.3倍的另外三 种基因和未增加的3种基因允许基因表达的下层的标准建立起来，如在文中所述。
[27]图5.(S2).在HCT116细胞中35种上层基因的基因表达和甲基化确证。 HCT116候选过度甲基化基因的清单，其被选择用于表达(通过HCT116和DKO 细胞的RT-PCR)和启动子甲基化(通过HCT116和DKO细胞的MSP)状况的确 证。基因描述在图的左边示出，基因名称在PCR结果后示出。水(RT-PCR和MSP)、 在体外甲基化DNA(MSP的IVD)和肌动蛋白B(ACTB)用为每一单个基因的 对照；显示了代表性的样品。绿色箭头鉴定验证了阵列结果的基因，红色箭头鉴 定那些没有验证阵列结果的基因。
[28]图6.(S3.)35种HCT116候选下层基因的清单，其被选择用于确证表达 (通过HCT116和DKO细胞的RT-PCR)和启动子甲基化(通过HCT116和DKO 细胞的MSP)状况。在图的左边示出了基因名称，基因名称在PCR结果后面显示。 水(RT-PCR和MSP)、体外甲基化DNA(MSP的IVD)和肌动蛋白B(ACTB) 用作每一单个基因的对照；显示了代表性的样品。绿色箭头鉴定验证了阵列结果 的基因，红色箭头鉴定那些没有验证阵列结果的基因，如文中所论述地。
[29]图7.(S4.)48种SW480候选上层基因的清单，其被选择用于确证表达 (通过SW480和DAC处理的SW480细胞的RT-PCR)和启动子甲基化(通过 SW480和DAC处理的SW480细胞的RT-PCR)状况。在图的左边指出了基因名 称，基因名称在PCR结果后面显示。水(RT-PCR)、体外甲基化DNA(MSP的 IVD)和肌动蛋白B(ACTB)用作每一单个基因的对照；显示了代表性的样品。 绿色箭头鉴定验证了阵列结果的基因，红色箭头鉴定那些没有验证阵列结果的基 因，如文中所论述地。
[30]图8.(表S1.)过度甲基化组大小的定量估计。细胞系和层在左边指出， 和每层中鉴定的基因表达变化的数量也被示出。关于每层候选过度甲基化基因库 的大小的计算通过每层鉴定的基因表达变化乘以0.86(HCT116的上层)、0.65 (SW480、CaCO2、HT29、COLO320和RKO的上层)或者0.49(HCT116、SW480、 CaCO2、HT29、COLO320和RKO下层)来进行。这些分数代表了实验所确定的 确认频率，如在本文所描述的。HCT116过度甲基化组大小的估计源于如下：532 的86％＝457上层基因加上1190的49％＝583下层基因；457+583＝1040。依照如下 计算，SW480过度甲基化组估计在579个基因：318上层的66％＝207和759下层 的49％＝372；207+372＝579。过度甲基化组基因清单和在乳腺癌或者结肠癌中突变 的基因之间的重叠在右边显示。
[31]图9.(表1)关于在序列表中的序列的信息。基因编号：基因流水号。 基因名称：在专利中使用的基因名称。基因ID：NCBI系统的基因ID。与基因ID 相关的转录物ID：来自ENSEMBL注释系统的所有转录物IDs，与具有相同TSS[转 录起始位置；注意，基因ID可以具有多个TSS，因而多转录物IDs通过它们的TSS 来分组]的特定基因ID相关。SEQ ID NO：1-125：基因组序列前后序列(从转录物 TSS的5′1000bp，到转录物TSS 3′的200bp)；如在NCBI build 36中发现的基因 组DNA序列。SEQ ID NO：126-250：亚硫酸氢盐转化形式的序列，假设所有CpG 二核苷酸的全甲基化存在。
[32]图10-截止比(ratio cut-off)20的散射图BNIP3。
[33]图11-截止比20的散射图FOXE1。
[34]图12-截止比100的散射图SYNE1。
[35]图13-截止比300的散射图SOX17。
[36]图14-截止比20的散射图JAM3。
[37]图15-截止比150的散射图MMP2。说明：这个标记在76个对照和90 个病例中进行了测试。
[38]图16-截止比150的散射图GPNMB。说明：这个标记在76个对照和90 个病例中进行了测试。
发明详述
[39]我们描述了人类全转录物组微阵列筛查来鉴定在人类CRC中被启动子过 度甲基化所沉默的基因。这种方法容易以高的证实效率在单个肿瘤中鉴定候选癌 基因。通过比较一系列候选过度甲基化基因与最近在CRC(3)中鉴定的突变基因， 我们建立了改变的肿瘤基因组和基因过度甲基化组之间关键的关系。我们的研究 提供了理解表观和遗传的改变如何促使人肿瘤发生的平台。
[40]我们描述了基因表达方法，对于可获得代表性细胞培养系的任何人类癌 症类型，该方法具有确定大部分癌基因启动子CpG岛DNA过度甲基化组的能力。 对这些基因的研究将有助于理解促使肿瘤发生的分子通路、提供有用的新DNA过 度甲基化生物标记来监测癌症风险评估、早期诊断和预后，并且允许在癌症预防 和/或治疗策略期间更好地监测基因再表达(13，22)。
[41]通过由我们方法发现的过度甲基化组基因与由基因组广泛测序策略 (genome wide sequencing strategy)鉴定的突变基因的直接比较，我们证明了在任 何特定的肿瘤中存在比遗传变化基因多许多的外遗传(表观)变化基因。这个事实的 重要性在我们的发现中显现：对于受两种机制影响的新发现的基因，在结肠癌中 任何特定基因的过度甲基化的发生率显得比突变高得多。因此，在特定的癌类型 中，由于未能筛查遗传和表观遗传异常，本领域技术人员可能明显地低估全范围 的基因改变和相关的细胞通路异常。数据也指出，比单独遗传分析所预测的，评 估基因功能丧失的两种机制对于通路中断在个体结肠肿瘤中显示出更多的共性 (sharing)。我们的发现强调，依照在关键通路中的分子改变对肿瘤分类的最佳方法 应该依赖于确定遗传和表观基因变化。因此，我们的发现应该促进在癌症中绘制 异常基因变化的任何基因广泛策略，从而考虑：应该检查突变基因的启动子DNA 过度甲基化和DNA过度甲基化基因应该放在进行测序以发现突变的优先位置。
[42]使用这种技术，我们已经发现了一组基因，它们的转录在癌、癌前体和 初癌中被外遗传沉默。这些基因包括：BOLL、CABYR、EFEMP1、FBLN2、FOXL2、 GNB4、GSTM3、HoxD1、Jph3、神经化的(NEURL)、PPP1R14a、TP53AP1、 RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、 LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、 FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、 TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、 FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、 RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、 MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3 和ZNF655。检测到这些基因的至少1、2、3、4、5、6、7、8、9或10个的外遗 传沉默可以用作癌或者初癌或者发展癌的风险的指示。
[43]基因的外遗传沉默可以通过在本领域中任何已知的方法确定。一种方法 是确定在正常细胞或者其它对照细胞中表达的基因在肿瘤细胞中较少表达或者不 表达。然而这种方法本身不能够指出沉默是外遗传性的，因为沉默的机制可能是 遗传的，例如通过体细胞突变。一种确定沉默是外遗传的方法是用试剂如DAC(5′- 去氮杂胞苷)(5′-deazacytidine)或者用改变细胞DNA的组蛋白乙酰化状况的试 剂来处理，或者影响在细胞中的外遗传机制的任何其它处理，并且观察沉默被逆 转，也就是基因的表达被再激活或者恢复。另一种确定外遗传沉默的方法是确定 在沉默基因中甲基化的CpG二核苷酸基序的存在。典型地，这些存在于转录起始 位置的附近，例如在大约1kbp之内、大约在750bp之内或者大约在500bp之内。 一旦基因被鉴定为在肿瘤细胞中外遗传沉默的靶标，减少表达的确定可以用作外 遗传沉默的指示物。
[44]基因的表达可以使用本领域已知的任何方法来评估。典型地，表达可以 在试样和对照样品中评估和比较，对照样品是正常的、非恶性的细胞。试样可以 含有癌细胞或者初癌细胞或者来自它们的核酸。例如，样品可以含有结肠腺瘤细 胞、结肠晚期腺瘤细胞或者结肠癌细胞。mRNA(核酸)或者蛋白可以被测量。可 以使用应用与核酸探针杂交的方法测量具体的mRNAs。这些方法包括使用核酸探 针阵列(微阵列技术)、原位杂交和使用Northern印迹。信使RNA也可以使用扩 增技术如RT-PCR来评估。基因组技术中的进步现在允许同时分析数千个基因， 虽然许多是根据特定探针-靶标杂交的相同概念。测序为基础的方法是可选的；这 些方法开始时使用表达的序列标签(EST)，并且现在包括基于短标签的方法，例 如基因表达系列分析(SAGE)和大规模平行特征测序(MPSS)。差别显示技术 提供了分析基因表达的另外方法；这类技术基于由限制性消化产生的cDNA片段 的随机扩增，以及在两种组织之间不同的带鉴定感兴趣的cDNA。特定的蛋白可以 使用任何常规方法来评估，包括但不限于免疫测定和免疫细胞化学术。大部分这 些方法将使用对特定的蛋白或者蛋白片段特异的抗体。本发明的标记的mRNA (cDNA)和蛋白的序列在本领域是已知的和可以公开得到的。
[45]甲基化敏感的限制性内切核酸酶可以用于检测甲基化的CpG二核苷酸 基序。这种核酸内切酶可以相对于非甲基化识别位点而优先剪切甲基化识别位点， 或者相对于甲基化识别位点而优先剪切非甲基化的识别位点。前者的例子是Ace III、Ban I、BstN I、Msp I和Xma I。后者的例子是Ace II、Ava I、BssH II、BstU I、 Hpa II和Not I。可选地，可以使用选择性地修饰甲基化的或者非甲基化形式的CpG 二核苷酸基序的化学试剂。
[46]修饰产物可以直接检测或者在产生容易辨别的产物的进一步反应之后进 行检测。检测改变的大小和/或电荷的方法可以用于检测修饰的产物，方法包括但 不限于电泳、色谱和质谱。这种选择性修饰的化学试剂例子包括肼和亚硫酸氢盐 离子。肼修饰的DNA可以使用哌啶处理来剪切它。亚硫酸氢盐离子处理的DNA 可以用碱来处理。其它依赖特定序列的方法也可以使用，包括但不限于杂交、扩 增、测序和连接酶链反应。如果期望，可以使用这些技术的组合。
[47]电泳的原理是通过它们的大小和电荷来分离核酸。存在用于检测甲基化 的许多测定方法，并且大部分依赖于确定特定核酸产物的有无。在实验室中为了 此目的经常使用凝胶电泳。
[48]本领域技术人员可以使用MALDI质谱结合甲基化检测分析来观察核酸 产物的大小。质谱的原理是对核酸进行离子化和依照它们的质荷比来分离它们。 类似于电泳，本领域技术人员可以使用质谱来检测在实验中产生的特定核酸以确 定甲基化。参见Tost，J.等，Analysis and accurate quantification of CpG methylation by MALDI mass spectrometry.Nuc Acid Res，2003，31，9。
[49]一种形式的色谱，高效液相色谱用于根据被分析物质与色谱柱之间的各 种化学相互作用来分离混合物的成分。DNA首先用亚硫酸氢钠来处理，其将未甲 基化的胞嘧啶转化成为尿嘧啶，而甲基化的胞嘧啶残基保持不受影响。本领域技 术人员可以经过PCR扩增含有潜在甲基化位置的区域和通过变性高效液相色谱 (DHPLC)来分离产物。DHPLC具有区别甲基化的(含有胞嘧啶)和没有甲基化 的(含有尿嘧啶)DNA序列的分辨能力。参见Deng，D.等，Simultaneous detection of CpG methylation and single nucleotide polymorphism by denaturing high performance liquid chromatography.2002Nuc Acid Res，30，3。
[50]杂交是根据两条互补核酸链的退火形成双链分子来检测特定核酸序列的 技术。杂交使用的一个例子是用于确定DNA甲基化状况的微阵列分析。在亚硫酸 氢钠处理DNA之后——其将未甲基化的胞嘧啶转变成为尿嘧啶，而甲基化的胞嘧 啶残基保持不受影响，与潜在甲基化位点互补的寡核苷酸可以与亚硫酸氢盐处理 的DNA杂交。寡核苷酸被设计成与含有尿嘧啶的序列或者含有胞嘧啶的序列互补， 其分别代表了未甲基化的和甲基化的DNA。以计算机为基础的微阵列技术可以确 定哪个寡核苷酸与DNA序列杂交，并且本领域技术人员可以推断DNA的甲基化 状况。
[51]确定在亚硫酸氢钠处理后结果的另外的方法将会是对DNA测序，以直接 观察任何亚硫酸盐的修饰。焦磷酸测序(Pyrosequecing)技术是通过合成测序的实时 方法。它基于焦磷酸盐(PPi)的间接生物光度计分析(bioluminometric assay)， 焦磷酸盐(PPi)是当DNA链延伸时从每个脱氧核苷酸(dNTP)中释放。这种方 法在核酸外切酶缺陷的Klenow DNA聚合酶存在的情况下呈现带有dNTP的DNA 模板-引物复合体。四种核苷酸以预先确定的顺序依次加到反应混合物中。如果核 苷酸与模板碱基互补并因而被加入，那么PPi被释放。PPi和其它试剂用作在荧光 素酶反应中的底物，荧光素酶反应产生通过光度计或者电荷耦合装置检测的可见 光。产生的光与加到DNA引物的核苷酸数量成比例，并且产生以热解图的形式存 在的指示核苷酸数量和类型的峰。焦磷酸测序可以利用在DNA的亚硫酸氢钠转化 后产生的序列差异。
[52]各种扩增技术可以在产生可辨别产物的反应中使用。这些技术的一些利用 PCR。其它合适的扩增方法包括连接酶链反应(LCR)(Barringer等，1990)、转 录扩增(Kwoh等.1989；WO88/10315)、目标多核苷酸序列的选择性扩增(美国 专利6,410,276)、共有序列引发的聚合酶链反应(美国专利4,437,975)、随机引 发的聚合酶链反应(WO90/06995)、核酸序列依赖性扩增(NASBA)(美国专利 5,409,818；5,554,517；6,063,603)、切口置换扩增(nick displacement amplification) (WO2004/067726)。
[53]反映原始基因组DNA中CpG二核苷酸处的甲基化状况的序列变化提供 了PCR引物设计的两种方法。在第一种方法中，引物自身不“覆盖”任何潜在的DNA 甲基化位点或者不与任何潜在的DNA甲基化位点杂交；在不同甲基化的位点处的 序列变化位于两引物之间。这种引物被用在亚硫酸氢盐基因组测序、COBRA、 Ms-SNuPE中。在第二种方法中，引物设计为特异地与甲基化的或者未甲基化形式 的转化序列退火。如果与靶标具有足够的互补性区域，例如12、15、18或20个 核苷酸，那么引物也可以含有另外的不干扰杂交、但对于其它操作有用的核苷酸 残基。这种其它残基的例子可以是限制性内切核酸酶剪切、配体结合或者因子结 合或连接体或重复序列的位点。寡核苷酸引物可以是或者可以不是这种对修饰的 甲基化残基特异的。
[54]区别修饰和未修饰的DNA的一种方式是杂交寡核苷酸引物，该寡核苷酸 引物特异地结合到DNA的一种形式或者另一种形式。在杂交后，可以进行扩增反 应和测定扩增产物。扩增产物的存在表明与引物杂交的样品。引物的特异性表明 DNA是否已经被修饰或未被修饰，其转而表明DNA是否已经被甲基化或未甲基 化。例如，亚硫酸氢盐离子修饰非甲基化的胞嘧啶碱基，将它们变为尿嘧啶碱基。 在杂交条件下，尿嘧啶碱基与腺嘌呤碱基杂交。因此，包含替代鸟嘌呤碱基的腺 嘌呤碱基的寡核苷酸引物会与亚硫酸氢盐修饰的DNA杂交，而含有鸟嘌呤碱基的 寡核苷酸引物会与DNA中未修饰的(甲基化的)胞嘧啶残基杂交。使用DNA聚 合酶和第二引物的扩增产生能够容易被观察到的扩增产物。这种方法被称为MSP (甲基化特异性PCR；专利5,786,146；6,017,704；6,200,756)。扩增产物可以任 选地杂交特异的寡核苷酸探针，而特异的寡核苷酸探针对某些产物也可以是特异 的。可选地，可以使用将与来自修饰和未修饰DNA的扩增产物杂交的寡核苷酸探 针。
[55]区别修饰和未修饰的DNA的另一种方式是使用对于某些产物也可以是 特异的寡核苷酸探针。这类探针可以直接与修饰的DNA或者修饰的DNA的扩增 产物杂交。可以使用本领域已知的任何检测系统来标记寡核苷酸探针。这些包括 但不限于荧光部分、放射性同位素标记的部分、生物发光部分、发冷光的部分、 化学发光的部分、酶、底物、受体或者配体。
[56]鉴定甲基化的CpG二核苷酸的还有另外一种方式是利用McCP2蛋白的 MBD结构域选择性地结合到甲基化DNA序列的能力(Cross等，1994；Shiraishi 等，1999)。限制性内切核酸酶消化的基因组DNA被加载在表达的His标记的甲 基CPG结合结构域上，CPG结合结构域被固定到固体基质和用于制备型柱层析来 分离高度甲基化的DNA序列。
[57]实时化学术使得能在反应的早期阶段期间检测PCR扩增，和使得DNA 和RNA的定量更容易和更准确。实时PCR的少数变化是已知的。它们包括 TaqManTM系统和Molecular Beacon(分子信标)TM系统，它们具有分开的用荧光团和 荧光淬灭剂标记的探针。在ScorpionTM系统中，发夹结构形式的标记的探针被连接 到引物。
[58]用许多技术已经成功进行了DNA甲基化分析，其包括MALDI-TOFF、 MassARRAY、MethyLight、乙基化等位基因的定量分析(QAMA)、酶区域甲基 化测定(ERMA)、HeavyMethyl、QBSUPT、MS-SNuPE、MethylQuant、定量PCR 测序和寡核苷酸为基础的微阵列系统。
[59]其沉默被测试和/或检测的基因数量可以变化：一、二、三、四、五或者 更多种基因可以被测试和/或检测。在一些情况下，选择至少两种基因。在另外的 实施方式中，选择至少三种基因。
[60]可以进行诊断性测试或者结合治疗方案进行测试。测试可以用于监测治 疗方案的效力，无论是化学治疗剂或者生物试剂如多核苷酸。测试也可以用于确 定什么样的治疗或者预防方案应用到患者上。而且，测试也可以用于把患者分成 几组用于测试试剂和确定它们在各组患者上的效力。
[61]用于诊断、预后或者个体化医学用途的测试样品可以从以下获得：外科 手术样品如活组织检查或者细针抽出液，石蜡包埋结肠、直肠、小肠、胃、食管、 骨髓、乳腺、卵巢、前列腺、肾、肺、脑等器官组织，体液如血液、血清、淋巴、 脑脊液、唾液、痰、支气管灌洗液、导管流体粪便、尿液、淋巴结或精液。这些 来源不是意欲穷尽性的，而是示例性的。从这些样品或者流体中获得的测试样品 包括分离的肿瘤细胞和/或从死亡或者损伤肿瘤细胞中释放的游离核酸。核酸包括 RNA、基因组DNA、线粒体DNA、单或双链和蛋白结合的核酸。从这种样品细 胞获得的纯化或未纯化形式的任何核酸样品可以用作起始核酸(一种或多种)。
[62]脱甲基剂可以与细胞在体外或者体内接触，目的是恢复细胞的正常基因 表达。合适的脱甲基剂包括但不限于5-氮杂-2′-脱氧胞苷、5-氮杂-胞苷、泽布拉恩 (Zebularine)、普鲁卡因和L-乙硫氨酸。这个反应可以用于诊断、用于确定倾向 和用于确定合适的治疗方案。如果脱甲基剂用于治疗结肠癌、头颈癌、食管癌、 胃癌、胰腺癌或肝癌，可以测试基因的表达或者甲基化，所述基因选自：BOLL、 CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化 (NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、 EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、 CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、 SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、 ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、 MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、 CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、 TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。
[63]恢复外遗传性沉默的基因表达的可选方式是将非甲基化的多核苷酸引入 细胞，这样它将在细胞中表达。各种基因治疗载体和媒介物在本领域中是已知的 和任何一种可使用的适合于特定的情况。某些载体适合于短期表达，而某些载体 适合于长时间表达。某些载体对于某些器官是有关营养的并且这些载体可以在特 定情况下适当使用。载体可以是病毒的或者非病毒的。多核苷酸可以但不是必要 的包含在载体例如病毒载体中，并且其可以配制在例如基质中，如脂质体、微泡。 通过将多核苷酸给予对象使得其接触细胞并被细胞吸收，多核苷酸可以被引入细 胞，并且编码的多肽被表达。优选地，特定多核苷酸将是患者已经被对其测试和 被发现携带沉默形式的多核苷酸。用于治疗结肠癌、头颈癌、食管癌、胃癌、胰 腺癌、肝癌的多核苷酸将典型地编码选自以下的基因：BOLL、CABYR、EFEMP1、 FBLN2、F0XL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、 TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、 CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、 DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、 SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、 EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、 PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、 CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、 ZNF345、DKK3和ZNF655。
[64]通过将脱甲基剂给予对象，将通常显示出甲基化沉默基因表达的细胞与 与脱甲基剂体内接触。如果方便，可以使用例如导管插入术方法给予脱甲基剂， 给予的地方在对象中显示不受调节生长的细胞的位置或者附近，或者给予进入到 血流到细胞位置的血管中。类似地，如果待被处理的器官或者其部分可以通过分 路方法被分离，试剂可以通过分路给予，因而实质上将试剂提供到含有细胞的位 置。试剂也可以全身给予或者通过本领域已知的其它途径给予。
[65]除了多肽编码序列外，多核苷酸可以包括可操作地连接的转录调控元 件、翻译调控元件等，和多核苷酸可以是裸露DNA分子的形式，其可以包含在载 体中或者其可以配制在基质如脂质体或微泡中，这帮助多核苷酸进入特定的细胞 中。术语“可操作地连接的(operatively linked)”指的是两个或者多个相互放置 的分子，这样它们作为单一的单元起作用和实现可归因于一个或者两个分子或者 其组合的功能。编码期望多肽的多核苷酸序列可以可操作地连接到调控元件，在 这种情况下，调控元件以类似于这样的方式在多核苷酸上赋予它的调控作用，在 该方式中，调控元件会影响在细胞中其与之正常联系的多核苷酸序列。
[66]编码待被给予哺乳动物或者人或待与细胞接触的期望多肽的多核苷酸可 以含有启动子序列——启动子序列可以提供多核苷酸的组成型，或者如果期望， 诱导型或者组织特异性或者发育阶段特异性表达、多聚腺苷酸(polyA)识别序列 和核糖体识别位点或者内部核糖体进入位点或者其它调控元件如增强子，其可以 是组织特异的。载体也可以含有在原核或者真核宿主系统或两者中复制所需要的 元件，如所期望的。这种载体——包括质粒载体和病毒载体如噬菌体、杆状病毒、 逆转录病毒、慢病毒、腺病毒、牛痘病毒、塞姆利基森林病毒(semliki forest virus) 和腺病相关病毒载体——是众所周知的和可以从商业来源购买(Promega，Madison WL；Stratagene，La Jolla CA.；GIBCO/BRL，Gaithersburg MD.)或者可以由本领域 技术人员来构建(参见例如Meth.Enzymol.，Vol.185，Goeddel，ed.(Academic Press， Inc.，1990)；Jolly，Cane.Gene.Ther.1：51-64，1994；Flotte，J.Bioenerg.Biomemb. 25：37-42，1993；Kirshenbaum等.，J.Clin.Invest.92：381-387，1993；它们中的每一个 在此引入作为参考)。
[67]四环素(tet)诱导型启动子可以用于促使编码期望多肽的多核苷酸的表 达。当将四环素或者四环素类似物给予含有可操作地连接到tet诱导型启动子的多 核苷酸的对象时，编码多肽的表达被诱导。多核苷酸可选地可以被可操作地连接 到组织特异性调控元件，例如肝细胞特异性调控元件如α胎蛋白启动子(Kanai等.， Cancer Res.57：461-465，1997；He等.，J.Exp.Clin.Cancer Res.19：183-187，2000)或 者白蛋白启动子(Power等.，Biochem.Biophys.Res.Comm.203：1447-1456，1994； Kuriyama等.，Int.J.Cancer 71：470-475，1997)；肌细胞特异性调控元件如肌红蛋 白启动子(Devlin等.，J.Biol.Chem.264：13896-13901，1989；Yan等.，J.Biol.Chem. 276：17361-17366，2001)；前列腺细胞特异性调控元件如PSA启动子(Schuur等.， J.Biol.Chem.271：7043-7051，1996；Latham等.，Cancer Res.60：334-341，2000)； 胰腺细胞特异性调控元件如弹性蛋白酶启动子(Ornitz等.，Nature 313：600-602， 1985；Swift等.，Genes Devel.3：687-696，1989)；白细胞特异性调控元件如增白细 胞蛋白(leukosialin)(CD43)启动子(Shelley等.，Biochem.J.270：569-576，1990； Kudo和Fukuda，J.Biol.Chem.270：13298-13302，1995)等，这样多肽的表达限制于 个体中的特定细胞或者限制于在培养中，例如在器官培养中的混合细胞群中的特 定细胞。包括组织特异性调控元件在内的调控元件在本领域中是众所周知的(参 见例如InvivoGen；San Diego Calif.)，许多组织特异性调控元件是商业可获得的。
[68]病毒表达载体可以用于将多核苷酸引入细胞中，特别是受试者的细胞中。 病毒载体提供了它们能够以相对高的效率感染宿主细胞和能够感染特定细胞类型 的优势。例如，编码期望多肽的多核苷酸可以被克隆进入杆状病毒载体，其随后 可以用于感染昆虫宿主细胞，由此提供了产生大量的编码多肽的方法。病毒载体 已被开发用在特定宿主系统，特别是哺乳动物系统中，病毒载体包括例如逆转录 病毒载体、其它慢病毒载，如那些基于人类免疫缺陷病毒(HIV)的载体、腺病毒 载体、腺相关病毒载体、疱疹病毒载体、肝炎病毒载体、牛痘病毒载体等(参见 Miller和Rosman，BioTechniques 7：980-990，1992；Anderson等.，Nature 392：25-30 Suppl.，1998；Verma和Somia，Nature 389：239-242，1997；Wilson，New Engl.J.Med. 334：1185-1187(1996)，它们中的每一篇在此引入作为参考)。
[69]多核苷酸——其可以任选地包含在载体中——可以通过在本领域中已知 的各种方法中的任一种被引入细胞(Sambrook等.，supra，1989；Ausubel等.，Current Protocols in Molecular Biology，John Wiley and Sons，Baltimore，Md.(1987和 supplements through 1995)，它们中的每一篇在此引入作为参考)。这些方法包括 例如转染、脂转染、显微注射、电穿孔和用病毒载体进行的感染；和可以包括应 用脂质体、微乳液等，脂质体、微乳液等可以帮助将多核苷酸引入细胞和可以保 护多核苷酸在引入细胞之前免于降解。特别有用的方法包括使多核苷酸并入微泡， 微泡可以注射入循环中。可以放置超声源，这样超声被传送给肿瘤，其中由于超 声，含有多核苷酸的循环微泡在肿瘤位置被破裂，因此在癌症的位置提供多核苷 酸。特定方法的选择将依赖于例如多核苷酸被引入的细胞以及细胞是否在培养中 或在体内原位位置。
[70]通过用病毒载体感染而将多核苷酸引入细胞可以有效地将核酸分子引 入细胞。而且，病毒是非常特异的，并可以根据在一种或者几种特定细胞类型中 的感染和繁殖的能力，来选择病毒作为载体。因此，它们天然的特异性可以用于 将包含在载体中的核酸分子靶向特定的细胞类型。基于HIV的载体可以用于感染 T细胞、基于腺病毒的载体可以用于例如感染呼吸道上皮细胞、基于疱疹病毒的载 体可以用于感染神经细胞等。其它载体，如腺相关病毒可以具有更大的宿主细胞 范围，因而可以用感染各种细胞类型，虽然病毒或者非病毒载体也可以用特定的 受体或者配体修饰，以通过受体介导的事件来改变靶标特异性。本发明的多核苷 酸或者含有多核苷酸的载体可以包含在细胞，例如宿主细胞中——宿主细胞使得 含有多核苷酸的载体得以繁殖，或者辅助细胞中——辅助细胞使得含有多核苷酸 的病毒载体得到包装。多核苷酸可以短暂地包含在细胞中，或者可以由于例如整 合进入细胞基因组中而被稳定维持。
[71]由基因(BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、 HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、 GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、 ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、 LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TF3、POMC、SOX17、 STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、 CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、 NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、 CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、 TSPYL6、ZNF345或ZNF655)编码的多肽可以直接给予到在受试者中显示出不受 调节的生长的细胞部位。如果期望的话，多肽可以使用本文公开的方法产生、分 离和配制，并且多肽可以与细胞接触，这样多肽可以穿过靶细胞的细胞膜。多肽 可以作为融合蛋白的一部分提供，融合蛋白包括有利于转运通过细胞膜的肽或者 多肽成分。例如，人类免疫缺陷病毒(HIV)TAT蛋白转导结构域或者核定位结 构域可以融合到感兴趣的标记。给予的多肽可以配制在基质中，基质帮助多肽进 入细胞。
[72]虽然在这里提到了特定多核苷酸和多肽序列作为已知基因和蛋白的代 表，但是本领域技术人员会理解，在数据库中的序列代表了在特定个体中存在的 序列。来自其它个体的任何等位基因序列也可以使用。这些典型地与公开的序列 变化1-10残基、1-5个残基或者1-3个残基。而且，等位基因序列与数据库序列典 型地具有至少95、96、97、98或者99％的同一性，同一性如使用运算法则如BLAST 同源性工具进行测量。
[73]试剂如脱甲基剂、多核苷酸或多肽典型地配制在适合给予受试者的组合 物中。因此，本发明提供了含有试剂的组合物，该试剂可用于恢复细胞受调节的 生长，该细胞由于一种或者多种基因的甲基化沉默转录而显示出不受调节的生长。 试剂作为治疗患有与这种不受调节生长相关的病理状况的受试者的药物是有用 的。这种药物通常包括载体。可接受的载体在本领域中是众所周知的和包括例如 水溶液诸如水或者生理缓冲盐水或者其它溶剂或者媒介物如乙二醇、丙三醇，油 如橄榄油或者可注射的有机酯。可接受的载体可以含有生理上可接受的化合物， 化合物起例如稳定或者增加结合物的吸收的作用。这种生理上可接受的化合物包 括例如糖类如葡萄糖、蔗糖或葡聚糖，抗氧化剂如抗坏血酸或谷胱甘肽，螯合剂、 低分子量蛋白或者其它稳定剂或者赋形剂。本领域技术人员会知道或者能够容易 地确定可接受载体，包括生理上可接受的化合物。载体的性质依赖于治疗剂的物 化性质和组合物的给药途径。治疗剂或者药物的给予可以通过口服途径或肠胃外 途径例如静脉内、肌内、皮下、经皮、鼻内、支气管内、阴道、直肠、瘤内途径 或者在本领域中已知的其它方法进行。药物组合物也可以含有一种或者多种另外 的治疗剂。
[74]治疗剂可以包含在封装材料里面，例如包含在水包油乳液、微乳液、胶 束、混合胶束、脂质体、微球体、微泡或者其它聚合物基质中(参见例如Gregoriadis， Liposome Technology，Vol.1(CRC Press，Boca Raton，FIa.1984)；Fraley，等.，Trends Biochem.Sci.，6：77(1981)，它们中的每一个在此引入作为参考)。例如由磷脂或 其它脂类组成的脂质体是无毒的、生理上可接受的可代谢载体，其制备和施用相 对简单。“隐形(Stealth)”脂质体(参见例如美国专利5,882,679；5,395,619； 和5,225,212，它们中的每一篇在此引入作为参考)是这种封装材料的例子，其对 于制备在本发明方法中有用的组合物特别有用，另外其它“掩蔽(masked)”脂 质体可以类似地使用，这种脂质体延长治疗剂停留在循环中的时间。例如阳离子 脂质体也可以用特定的受体或者配体进行修饰(Morishita等.，J.Clin.Invest.， 91：2580-2585(1993)，其在此引入作为参考)。另外，多核苷酸剂可以使用例如 腺病毒多聚赖氨酸DNA复合物引入细胞中(参见例如Michael等.，J.Biol.Chem. 268：6866-6869(1993)，其在此引入作为参考)。
[75]含有治疗剂的组合物的给药途径将部分依赖于分子的化学结构。多肽和 多核苷酸例如口服输送不是有效的，因为它们在消化道中可被降解。然而，例如 可以使用化学修饰多肽的方法，使它们更不易被内源性蛋白酶降解，或者使它们 更容易通过消化道吸收(参见例如Blondelle等.，supra，1995；Ecker和Crook，supra， 1995)。
[76]在实施本发明的方法中给予的试剂总量可以作为单剂量——或者作为大 丸剂或推注剂(弹丸，bolus)或者通过在相对短的时间段中输注——给予受试者， 或其可以使用分次治疗方案进行给予，在分次治疗方案中多剂量在长时间段中给 予。本领域技术人员会知道，在受试者中治疗病理症状的组合物的量依赖于多种 因素，包括受试者的年龄和总体健康以及给药途径和给予的治疗次数。考虑到这 些因素，本领域技术人员会根据需要调整具体的剂量。一般而言，最初使用I期和 II期临床试验来确定组合物的配方和给药的途径及频率。
[77]组合物可以配制用于口服制剂，例如片剂或者溶液或者悬浮液的形式； 或者组合物可以包含与适合于肠内或者非肠道应用的有机或者无机载体或者赋形 剂的混合物，和可以例如与常用、无毒、药学上可接受的载体化合，用于制备片 剂、丸剂、胶囊、栓剂、溶液、乳剂、悬浮剂或者其它适合应用的形式。除了在 以上所公开的那些载体外，载体可以包括葡萄糖、乳糖、甘露糖、阿拉伯胶、明 胶、甘露醇、淀粉糊、三硅酸镁、滑石、玉米淀粉、角蛋白、胶体二氧化硅、马 铃薯淀粉、尿素，中链长度甘油三酯、葡聚糖和适合用于制造固体、半固体或液 体形式的制备物的其它载体。另外，辅助剂、稳定剂、增稠剂或者着色剂和香料 也可以应用，例如稳定干燥试剂如丙酮糖(triulose)(参见例如美国专利5,314,695)。
[78]虽然通过使用标记的组合可以获得诊断和预后的准确性和灵敏性，例如5 或者6种标记、或者9或10种标记、或者14或15种标记的组合，但是实际考虑 可能决定使用更小的组合。特定癌症的标记的任何组合可以被使用，所述组合包 含2、3、4或5种标记。考虑到本文提供的单个标记的具体公开，可以容易地想 到2、3、4或5种标记的组合。
[79]差别甲基化GpG岛的甲基化水平可以提供关于疾病或者癌症的各种信 息。它可以用于在个体中诊断初癌或者癌症。初癌或者癌症前体是癌症的非常早 的阶段，它在结肠的最里(腔层)层中发现。它有时称为浅表癌(superficial cancer)。 可选地，它可以用于预测在个体中疾病或者癌症的过程，或者预测在个体中对疾 病或者癌症的易感性，或者对个体中疾病或者癌症的进展进行分级。它可以帮助 预测整体存活的可能性或预测疾病或癌症再次发生的可能性，并确定个体所经历 的疗程的有效性。当检测时，与参考水平相比的甲基化水平增加或者减少和增加/ 减少的改变提供了有用的预后和诊断价值。
[80]预后的方法可以用于鉴定可能发展为癌的腺瘤患者。这种预测可以根据 在腺瘤中相对于正常的组织在表1(图9)中所鉴定的至少一种基因的外遗传沉默 来进行。这些患者可以被提供另外合适的治疗或者预防选择，包括内镜息肉切除 术或者切除术，和当指出时，包括外科手术、化疗、放疗、生物反应调节剂或其 它疗法。这些患者也可以接受进一步诊断或者监测程序的建议，诊断或者监测程 序包括但不限于增加频率的结肠镜检查、乙状结肠镜检查、虚拟结肠镜检查、视 频囊内镜检查、PET-CT、分子成像或其它成像技术。
[81]治疗癌症患者的治疗策略可以根据外遗传沉默基因的再激活进行选择。首 先鉴定选自BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、 Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、 MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、 ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、 NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、 ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、 LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、 CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、 TRPC3、TSPYL6、ZNF345、DKK3和ZNF655的基因，所述基因在患者癌细胞中 的表达通过去甲基化试剂再激活或者外遗传沉默。随后选择增加基因表达的治疗。 这种治疗可以包括给予再激活剂或者多核苷酸。可选地可以给予多肽。
[82]依照本发明的试剂盒是用于测定甲基化的试剂的集合体。它们典型地在 含有所有成分的包装中，任选地包括说明书。包装可以分开，以便各成分不混合， 直到希望混合时。成分可以处于不同的物理状态。例如，一些成分可以是冻干的， 而一些在水溶液中。一些成分可以是冷冻的。在试剂盒内，单个的成分可以分开 包装。试剂盒可以含有如上描述的用于差异性修饰甲基化和非甲基化胞嘧啶残基 的试剂。理想地，试剂盒将含有寡核苷酸引物，该寡核苷酸引物与基因/标记的转 录起始位置的1kb内的区域特异性杂交，所述基因/标记为：BOLL、CABYR、 EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、 PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、 PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、 DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、 STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、 CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、 NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、 CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、 TSPYL6、ZNF345、DKK3和ZNF655。典型地，试剂盒将包含单个基因或者标记 的正向和反向引物。如果具有足够的互补区域，例如12、15、18或20个核苷酸， 那么引物也可以包含另外的核苷酸残基，这些核苷酸残基不干扰杂交，但是对其 它操作可能是有用的。这种其它残基的例子可以是限制性内切核酸酶剪切的位点， 用于配体结合或者用于因子结合或者连接体或者重复序列的位点。寡核苷酸引物 可以或者可以不对修饰的甲基化残基是特异的。试剂盒可任选地含有寡核苷酸探 针。探针可以对含有修饰的甲基画残基的序列或者对含有非甲基化残基的序列是 特异的。试剂盒可以任选地含有修饰甲基化胞嘧啶残基的试剂。试剂盒也可以含 有用于进行扩增的成分，例如DNA聚合酶和脱氧核糖核苷酸。检测工具也可以在 试剂盒中提供，包括在引物或者探针上的可检测的标记。试剂盒也可以含有用于 检测本发明的一种标记(表1；图9)的基因表达的试剂。这些试剂可以包括例如 探针、引物或者抗体。在酶或者配体的情况下，底物或者结合伴侣可以用于评估 标记的存在。
[83]在这个实施方式的一方面，基因与肼接触，肼修饰胞嘧啶残基，但是不 修饰甲基化的胞嘧啶残基，随后肼处理的基因序列与试剂如哌啶接触，该试剂在 肼修饰的胞嘧啶残基处剪切核酸分子，由此产生包含片段的产物。通过使用例如 电泳、色谱或者质谱的方法依照分子量分离片段，并比较该分离形式与类似处理 的相应非甲基化基因序列的分离形式，缺口在含有甲基化胞嘧啶残基的测试基因 中的位置上是明显的。因此，缺口的存在指示了在测试细胞的靶基因的CpG二核 苷酸中胞嘧啶残基的甲基化。
[84]亚硫酸氢盐离子例如亚硫酸氢钠将非甲基化的胞嘧啶残基转化为亚硫酸 氢盐修饰的胞嘧啶残基。亚硫酸氢盐离子处理的基因序列可以被暴露于碱性条件， 碱性条件将亚硫酸氢盐修饰的胞嘧啶残基转化为尿嘧啶残基。亚硫酸氢钠容易与 胞嘧啶的5，6-双键反应(但是与甲基化的胞嘧啶反应很差)形成磺酸化的胞嘧啶反 应中间产物，中间产物易于脱氨基，产生磺酸化的尿嘧啶。磺酸盐基团可以通过 暴露于碱性条件来除去，引起尿嘧啶的形成。DNA可以例如通过PCR扩增，并进 行测序来确定在样品的DNA中CpG位置是否被甲基化。尿嘧啶被Taq聚合酶识 别为胸腺嘧啶，而当PCR时，生成的产物仅在起始模板DNA中5-甲基胞嘧啶存 在的地方含有胞嘧啶。本领域技术人员可以比较在测试细胞的亚硫酸氢盐离子处 理的基因序列中尿嘧啶残基的量或者分布与类似处理的相应非甲基化基因序列中 的尿嘧啶残基的量或者分布。在测试细胞的基因中尿嘧啶残基的量或者分布的减 少表明在测试细胞基因的CpG二核苷酸中胞嘧啶残基的甲基化。尿嘧啶残基的量 或者分布也可以通过如下步骤检测：将亚硫酸氢盐离子处理的目标基因序列与寡 核苷酸接触、随后暴露于碱性条件并检测寡核苷酸的选择性的杂交(或者其不存 在)，所述寡核苷酸选择性地与目标基因的核苷酸序列杂交，该目标基因或者含 有尿嘧啶残基或者缺少尿嘧啶残基，但不是两者。
[85]测试化合物可以被测试它们治疗癌症的潜力。用于测试的癌细胞可以选 自前列腺癌、肺癌、乳腺癌和结肠癌。确定选自那些在表1(图9)中列出的基因 的表达，如果表达在细胞中被化合物增加，或者如果基因的甲基化在细胞中被化 合物减少，本领域技术人员可以鉴定该化合物具有作为治疗癌症的潜力。
[86]可选地，这些测试可以用于确定食管癌、头颈癌、胃癌、小肠癌、胰腺 癌、肝癌患者对化疗剂的反应。患者可以用化疗剂进行治疗。如果选自BOLL、 CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化 (NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、 EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、 CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、 SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、 ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、 MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、 CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、 TRPC3、TSPYL6、ZNF345、DKK3和ZNF655的基因的表达在癌细胞中被化合物 增加，或者如果基因的甲基化在癌细胞中被化合物减少，该化合物可以被选择用 于治疗患者。
[87]以上公开总体描述了本发明。所有在本文公开的参考文献通过引用明确 并入。更完整的理解可以通过参考以下具体的例子来获得，其在本文提供仅仅为 了举例说明的目的，而不是意欲限制本发明的范围。
实施例
实施例1
材料和方法
[88]细胞培养和处理。HCT116细胞和等基因遗传敲除衍生物如在以前描述 (14)地来维持。对于药物处理，对数期CRC细胞在McCoys 5A培养基(Invitrogen) 中培养96小时，McCoys 5A培养基含有10％BCS和1×青霉素/链霉素与5μM的 5氮杂-脱氧胞苷(DAC)(Sigma；储液：1mM，在PBS中)，每24小时更换培 养基和DAC。用300nM曲古柳菌素A(Sigma；储液：溶解在乙醇中的1.5mM) 处理细胞18小时。对照细胞平行进行模拟处理，加入没有药物的等体积PBS或者 乙醇。
[89]微阵列分析。依照制造商的指导——包括DNA酶消化步骤，使用Triazol (Invitrogen)和RNeasy试剂盒(Qiagen)从对数期细胞收获总RNA。使用NanoDrop ND-100，接着用2100Bioanalyzer(Agilent Technologies)进行质量评价，对RNA 定量。个体样品的RNA浓度大于200ng/ul、28s/18s比率大于2.2，和RNA完整值 为10(10为最高分)。使用低RNA输入荧光线性扩增试剂盒(Low RNA Input Fluorescent Linear Amplification Kit)(Agilent Technologies)，依照制造商的指导， 进行样品扩增和标记过程。标记的cRNA用RNeasy小型试剂盒(Qiagen)纯化和 定量。在扩增之前，RNA示踪对照(RNA spike-in control)(Agilent Technologies) 加入到RNA样品中。标记有Cy3或Cy5的0.75微克样品与对照靶标(Agilent Technologies)混合，依照Agilent微阵列方案聚集在寡微阵列(Oligo Microarray)上、 杂交和处理。用Agilent G2565BA微阵列扫描仪，使用Agilent Technologies推荐 的设置进行扫描。
[90]数据分析。所有阵列进行制造商所推荐的质量检查。视觉检查图像的假 象，检测信号的分布和红和绿两个通道的背景强度以鉴定异常的阵列。没有观察 到不规则，并且保留和使用所有阵列。使用R统计计算平台(23)和来自 Bioconductor生物信息软件项目(24)的程序包进行所有的计算。红信号与绿信号 的对数比在减去背景和LoEss归一化后进行计算，如在Bioconductor(25、26)的 半度软件包(limma package)中所执行地。单个阵列换算到有相同的四分位数 (inter-quartile)范围(第75个百分位数-第25个百分位数)。对于染色交换重复 (dye-swap replicate)微阵列，对数倍数变换进行平均，以产生每种条件的单一的 一组表达值。
[91]甲基化和基因表达分析。依照制造商的指导，用TRIzol试剂(Invitrogen) 分离RNA。对于反转录-PCR(RT-PCR)，1μg的总RNA通过使用Ready-To-GoTM You-Prime First-Strand Beads(Amersham Biosciences)进行反转录，加入随机六聚 体(每个反应0.2μg)。对于RT-引物设计，我们使用Primer3(http://frodo.wi.mit.edu/ cgi-bin/primer3/primer3_www.cgi)。对于MSP分析，依照标准的酚-氯仿提取方法 提取DNA。使用EZ DNA甲基化试剂盒(Zymo Research)进行基因组DNA的亚 硫酸氢盐修饰。使用MSPPrimer(http://www.mspprimer.org)，设计对未甲基化和 甲基化启动子序列特异的引物序列。MSP如以前描述(20)进行。所有PCR产物 (50μl总体积的15μl用于RT-PCR和25μl总体积的7.5μl用于MSP)直接加样在 含有GelStar Nucleic Acid Gel Stain(Cambrex Bio Science)的2％琼脂糖凝胶上， 并在紫外线照射下可视化。根据要求，用于MSP、亚硫酸氢盐测序和RT-PCR的 引物序列和条件可从作者得到。
[92]人肿瘤分析。来自原发性CRC的福尔马林固定的、石蜡包埋的组织从 Department of Pathology of the University Hospital Maastricht的档案库获得。获得了 马斯特里赫特大学(Maastricht University)、马斯特里赫特大学医院(University Hospital Maastricht)和美国约翰霍普金斯大学医院(Johns Hopkins University Hospital)的医学伦理委员会的批准。使用Puregene DNA分离试剂盒(Gentra Systems)分离DNA。
实施例2
[93]对于过度甲基化依赖基因表达变化的综合鉴定，我们的第一步通过在基 因组宽表达阵列为基础的方法中比较野生型HCT116CRC细胞与携带两种主要人 类DNA甲基转移酶的单独和组合的基因删除的等基因伴侣细胞来进行(图1A， 14)。重要地是，在DNMT1(-/-)DNMT3b(-/-)双敲除(DKO)HCT116细胞中—— 其实际上完全丧失了全部的5-甲基胞嘧啶，所有以前单个检查的过度甲基化基因 ——在野生型细胞中缺少基本表达——经受了伴随基因重新表达的启动子脱甲基 化(14-17)。通过依照在44K Agilent Technologies阵列平台上的改变的信号强度 将基因分级，当与等基因野生型亲代细胞或者等基因细胞系比较时，我们观察到 了在DKO细胞中基因表达增加的独特峰，在等基因野生型亲代细胞或者等基因细 胞系中DNMT的1或3b已经被个别地删除，其包含在DNA甲基化中最小的变化 (图1B)。
[94]根据我们以前的方法，我们使用药理学策略测试了我们的方法，但是现 在被明显地改良以提供全转录物组覆盖(19)，以鉴定在任何癌细胞系中沉默的 过度甲基化基因。对于致密的过度甲基化的和转录无活性的基因，DNA脱甲基剂 5-氮杂-2′-脱氧胞苷(DAC)具有充分确立的诱导基因重新表达的能力(18)。另 一方面，对于这些相同的基因，I和II类HDAC抑制剂曲古柳菌素A(TSA)将 不单独诱导重新表达(19)。在用DAC或者TSA处理HCT116细胞后(图1C)， 我们鉴定到这样的区域，在其中基因表达没有随着TSA增加(＜1.4倍)和在模拟 处理的细胞中没有显示可检测的表达。在这个区域内，我们观察到了DAC诱导的 基因表达的特征峰，其与在DKO细胞中所看见的基因表达增加相重叠(比较在图 1D中黄色点与在图1B中的蓝色点)。由于DAC整合入分裂细胞的DNA，而我 们的处理仅仅进行了96小时，与DKO细胞相比，在药理学方法中检测基因增加 的灵敏性被降低。这个基因峰的鉴定完全依赖于对没有对HDAC抑制作出反应的 唯一的基因进行分析，被簇分析加强，簇分析显示了在DKO和DAC处理细胞的 基因之间的亲密关系，在TSA单独处理后，DKO和DAC处理的细胞具有单独分 组的基因表达变化(图1E)。这些数据确认了覆盖很少基因组的先前研究，在其 中，带有致密CpG岛的被TSA再表达的基因没有包含可检测的甲基化(19)。基 因表达增加的类似峰可以在5种另外的人CRC细胞系(SW480、CaCO2、RKO、 HT29和COLO320)中看见，确认了这种方法在癌细胞系中普遍起作用(图2A)。
实施例3
[95]为了说明我们新阵列方法鉴定CpG岛过度甲基化基因的灵敏性，我们首 先检查了在HCT116细胞中11种已知被过度甲基化、完全沉默和在DAC处理后 重新表达的基因(图4(S1A))(14-17)。所有测试的基因保持在TSA未反应 区内(图4(S1B和C))，在DAC处理和DKO细胞中，表达变化的方向充分关 联(图4(S1D))。重要地是，对于DAC增加，5种指导基因(45％)增加2倍 或者2倍以上，以及另外3种基因或者总共73％的基因增加1.3倍或者1.3倍以上。
[96]根据在DKO与DAC诱导基因增加之间所观察到的灵敏性差异和指导基 因在阵列平台中的行为，在TSA阴性区域内，我们指定了基因的上层(2倍增加 或者以上)和下层(1.4倍至2倍之间的增加)来鉴定过度甲基化癌基因(图2B)。 我们也从这些区域中根据它们在未处理的细胞中没有基本表达来挑选基因。事实 上，在HCT116细胞中，总共532个基因的上层反应区中35个随机挑选的基因中 的30个基因(86％)，和来自318个上层基因的48个这样的SW480细胞基因的 31个基因(65％)证明被CpG过度甲基化——如通过MSP(20)所测量的，和在 来源的细胞系中被沉默——如通过RT-PCR测量的(图5、7(S2、S4)。我们也 检测了在DAC处理的HCT116细胞的下层中过度甲基化基因的发现效率。在这个 区域中的鉴定的1190个基因中，35个随机挑选的含有CpG岛的基因中的17个 (49％)被过度甲基化，具有一致的基因沉默(图6(S3))。这说明了与以前鉴 定新的癌过度甲基化基因的筛查相比(7、21)，我们的方法是特别有效的。以这 种证实的过度甲基化的水平，我们计算在HCT116细胞中过度甲基化组由估计的 1040个基因组成和对于SW480细胞由估计的579个基因组成(对于计算的详细描 述，参见图8(表S1))。过度甲基化组估计为从在CaCO2中的532个基因到 RKO细胞中的1389个基因的范围(图8(表S1))。在6个细胞系的所有层中鉴定 到总共5906个独特的基因，每个细胞系产生平均大约1000个过度甲基化组基因。
实施例4
[97]在细胞培养为基础的方法中根本的问题为是否它们鉴定了在原发性肿瘤 中作为失活靶标的基因。为了解决这个问题，来自证实的基因清单的含有CpG岛 的20个基因被从HCT116上层(17个基因)、HCT116下层(2个基因)或SW480 上层(1个基因)中随机选择，和分析在一组CRC细胞系中的甲基化。所有测试 的基因在2个或多个细胞系中被过度甲基化(图3A)。随后我们检测了在一组20 个到61个原发性结肠癌和20个到40个正常出现的结肠组织样品中的这20个基 因的状况，正常出现的结肠组织样品从无癌的个体中获得。在正常结肠组织样品 中，大部分基因(65％)完全没有被甲基化或者很少甲基化，但在绝大多数原发性 肿瘤中(86％)被甲基化(图3A)。分析的20个基因中，13个基因(65％)满足 在细胞系中具有高频率甲基化的“肿瘤特异性甲基化”的标准，在正常结肠中低的或 者未检测到的甲基化和在肿瘤样品中频繁的甲基化。我们策略的效率揭示在细胞 系中对于鉴定过度甲基化基因至少二分之一(1/2)的发现率，和对于鉴定癌症特异 性过度甲基化基因至少三分之一(1/3)的发现率。
实施例5
[98]虽然清楚的是，遗传和外遗传机制对人类肿瘤发生的起始和进展都是重 要的，但是对这些改变的每个的相对贡献了解不多。对少数癌基因甲基化和突变 频率之间的比较还没有令人信服地证明任一途径的普遍性。重要地是，还没有进 行全基因组分析来质疑这个问题。
[99]在最近的癌基因全基因组测序中，等(3)观察到突变一般而言 具有低的发生率，鉴定的90％的基因包含小于10％的突变频率。此外，典型的结 肠或者乳腺癌每个单个肿瘤仅含有平均11个突变，单个肿瘤之间具有很少的重叠。 这些低频率提出了这样的问题：是否可选的机制可能在另外的肿瘤中导致这些基 因的失活。显然，我们现在在个体肿瘤中鉴定到数量大得多的候选过度甲基化基 因(图2C)，这表示这种外遗传改变可能为许多肿瘤抑制基因的突变提供了可选 的失活途径。
[100]当我们搜索候选过度甲基化基因和189种突变癌(CAN)基因之间的 匹配时，筛查肿瘤的遗传和外遗传变化的重要性被显著加强。我们首先质疑我们 5906个过度甲基化组基因清单与在乳腺和CRC肿瘤中鉴定的CAN基因清单。这 鉴定了这56种共有基因，其中45种含有CpG岛。这些45种基因中的26种(58％) ——类似于如上所述鉴定的所有候选基因的证实率——证明在6个细胞系的至少1 个中被过度甲基化，并被选择用于进一步研究。重要地是，正好一半的基因(13 种基因)在正常结肠中未被甲基化，但是在原发性CRC肿瘤中被甲基化(图3B、 C)，给出了鉴定肿瘤特异性甲基化的50％的频率。对于事实上每种检查的基因， 过度甲基化的发生率显著高于突变的发生率(图3D)。因此，不同于突变的基因， 大多数基因的过度甲基化在许多肿瘤之间是共有的性质。在先前未表征的基因中 这些外遗传沉默和突变的发现巩固了它们作为肿瘤抑制基因的可能作用。(图3E)。
实施例6--收集的BNIP3、FOXE1、SYNE1、SOX17、JAM3、MMP2和GPNMB 的另外组织数据
材料和方法
用于组织确认的临床样品
[101]对应于77个正常组织和94个癌样品，总共171个结肠石蜡包埋的组织 样品使用实时MSP进行处理。表2给出了用于组织确认的样品组的概述。
表2-临床样品组的详细资料
石蜡包埋组织样品的DNA提取
[102]福尔马林固定的石蜡包埋样品首先在750μl的二甲苯中去除石蜡2小 时。然后，在以13000rpm离心15分钟之前，加入250μl的70％的乙醇。除去上 清液，并在室温下空气干燥样品20分钟。使用经典的酚/氯仿提取方法提取DNA， 并在50μl的LoTe(3mM TRIS，0.2mM EDTA，pH 8.0)中重悬浮。随后，使用 dsDNA定量试剂盒(Molecular Probes，Invitrogen)，依照制造商的推 荐对DNA定量。随试剂盒提供的λDNA用于制备标准曲线(从1到800ng/ml)。 使用FluoStar Galaxy平板读取器(BMG Lab technologies，德国)收集数据。
DNA修饰
[103]使用EZ-96DNA甲基化试剂盒(Zymo Research)，依照制造商的方案， 1μg的DNA在移液自动机(Tecan)上以96孔形式进行亚硫酸氢盐修饰。基本上， 等份的45μl与5μl的M-稀释缓冲液(M-Dilution Buffer)混合，并在37℃以1100rpm 摇动温育15分钟。接着加入100μl的稀释的CT转化试剂，样品在70℃、在黑暗 中以1100rpm摇动温育3小时。在转化后，通过在冰上温育10分钟进行和加入 400μl的M-结合缓冲液对样品脱盐。样品加样到收集盘中的Zymo-Spin I柱上，并 离心后，用200μl的M-洗涤缓冲液(M-Wash Buffer)洗涤。200μl的M-去磺化缓 冲液(M-Desulphonation Buffer)放置在柱上并在室温温育15分钟。在柱子离心后， 它们用200μl的M-洗涤缓冲液洗涤2次。最后，DNA在125μl Tris-HCl 1mM pH8.0 中从柱上洗脱和储存在-80℃，直到进一步的处理。
DNA扩增
[104]在7900HT快速实时PCR系统上(Applied Biosystems)应用实时MSP。 5μl修饰的DNA加到PCR混合物(总体积10μl)中，PCR混合物含有缓冲液(16.6 mM(NH4)2SO4、67mM Tris(pH 8.8)、6.7mM MgCl2、10mM β-巯基乙醇)、dNTPs (5mM)、正向引物(6ng)、反向引物(18ng)、分子信标(0.16μM)和Jumpstart DNA Taq聚合酶(0.4单位；Sigma Aldrich)。用于每个基因的引物序列和分子信标 序列总结在表3中。使用如下循环程序：5分钟95℃，接着45个30秒95℃、30 秒57℃和30秒72℃的循环。包括标准曲线(2×106-20拷贝)以通过内插它们的 Ct值到标准曲线来确定未知样品的拷贝数。
表3-引物序列和信标序列
在组织材料上的标记确认
[105]如以上所描述进行实验。使用在表3中详述的引物对和信标探针在组织 材料上确认结肠标记：BNIP3、FOXE1、SYNE1、SOX17、JAM3、MMP2和GPNMB。 另外，测量独立的参考β-肌动蛋白(ACTB)。使用SDS 2.2软件(Applied Biosystems) 产生结果并以Ct值(扩增曲线超过阈值的循环数量，由软件自动设定)输出。使 用标准曲线推算拷贝数。每个样品的感兴趣基因与ACTB的比率(乘以1000)用 作测量值，代表在每个样品内每个感兴趣基因的甲基化DNA的相对水平。
[106]在正常样品中(对照)和癌症(病例)中BNIP3、FOXE1、SYNE1、 SOX17、JAM3、MMP2和GPNMB的甲基化特异性PCR散射图在图10-16中显示。 测量值表示为甲基化比率，定义为与ACTB比较每个基因的荧光强度值的比率， 乘以1000，以便容易作表。
[107]如在图10-16中所指出，在调查的对照和病例组之间，观察到清楚的比 率差异。
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序列表
<110>S.拜林
<120>结肠癌的早期检测和预后
<130>006791.00012
<160>250
<170>FastSEQ for Windows Version 4.0
<210>1
<211>1200
<212>DNA
<213>智人(Homo sapiens)
<400>1
ccgcctcctc tccattttac agaggaggaa accgagggtt gagcggcgaa tgatttgccc 60
tgcctgccca gcacggaaaa aaatcactct tctggcccca gtcgcctccc tttctgtgct 120
gtgagtctgt gtccagagca ggaagggctg ctccgagctg cagggacggg ctctgtgtgt 180
taaaccttca aatggcttcc agggactcat ggagcatcca ggacacctgg agatggcgac 240
tcctgggacc cctggccctt ccctcctctg gccttcggtc cgtgagggtg aattaagtgt 300
gccacccacc aggggcagag acacatggag acagagattg agagacagag aacagagggg 360
gagacagaaa gagagaggga catgaagagc aacggagtta caggaggatc tgacgctccg 420
ttggggagac agggagaaat gtggggagat gcagcgtccc aggtgctccc cagtggccct 480
gcccctcctc ccctctcccc tccccaccag gcaggaccct cagggagctc cagcctggac 540
ccgaaccctg tcccaccctg acgcacctgc accaggccag gctggacctg tggggtgggt 600
gcaggcctgg ccccagcccg gccactgccc tggaaacccc tcccccgcca agatgctgat 660
gtaacatcca ggatttgatg ttttactctc caattctgca aatccagacg caggaggttt 720
taagaggccg ttgcaccctg caataaagtg cgggacacag gaatcttggt cctcggggca 780
cccccttccc tcgggggggt ttcgcccccc gcactcacgg cccctgagcc cgcgcggagg 840
cccgacgccc cgcggccgac gccggtcccc gccccgggcc gccattggct gttgccatgg 900
caccagcccg tcttcccgcg ccctcattgg ctgtctcacc cgcatccctc atcccgcatc 960
ctcccccgct cgcggtggtc tcgcccagcg ctaggagcgg cagcgccgcc tgcccaggcc 1020
cggaccgggc tttgtccgcc ccggagcccc tgcccgcgcc gcggagaccc cggagcccgc 1080
gcgctccgag gccaccccgg gccgggattt ccggtggggc ccgcggagcc gcgcagaggg 1140
aggaggcccc agacccaggc gccccgccag cccagctgca cgtaagcggg tgtgtgtcct 1200
<210>2
<211>1200
<212>DNA
<213>智人
<400>2
aaaactgtca tggttacagc catcaaatta caggaggttc acacacagca gtcagcaatg 60
gtttgggaat attaaataaa tgtgtttctc taacaggaca agacaggatc atttatttat 120
gcaacttaaa agctgtccca gaaggagaaa aaagtagcgt attatttgtc caaaataaac 180
aagattgaag aactgaacat ctctctgtgg atcaatttac agatcacatg gaaataggct 240
tatcttattg agaaatattc cattttagat gttcaaatac cttagcatat tttaaaaact 300
atttcctatg tgaccaaaag aattcatgtt ctattcggta aaaattaacc aaaattaacg 360
gtgctttcca atggacgcag gaaacctttt ttctttacaa aatatgccca cccttttttt 420
gttgctactt cccacattga attcttgttt tactgaattt tcttactata aaaataaagc 480
atgatgatag ttttgaaaac aaaacagaag tatttgagaa gtacagaccc cactcccact 540
ccttgtctcc tttctgacac tctgcccctt aactatactg gaacagggag tcaactgcaa 600
ggaaaatcct ggggactagg ggctgaggaa ctagaggtgg agagatggaa gagtgtccag 660
tagcccagga aaggatgaaa caattcccca acaaaaaagt aaaaattttc agtagccctc 720
cgagaagatg cagcccctcc caggtaacca gagaaaggca aattgtgaaa gcagggagaa 780
ggggctactt taggcctcca ggactacaaa gacaaaaaaa tgagtgacag gacctgatgt 840
ggtggggtga gatgggaatg gaagtaaagg agggggctcg tactcttggt gggagtggaa 900
attggggacc caagcttact ggcgatgcag ccctcacgtg accaggagct gacgtgggca 960
aaggtactta aagccctgac cgtcgttctc cgtcctcctc tgggtaccaa ctctattgcg 1020
cagctcgctg ccgtgcgttt aacccaggcg aggaggagga ggagaaaatt cccccagatt 1080
cgggcaggtg ggtgtgaggg tgggcacagt ctgggacccc tgaatagggt aatctaggga 1140
tgcgggagtc ggaggccgcg ggtgcctcgg tctcccccac tcctggccgg ctttccagac 1200
<210>3
<211>1200
<212>DNA
<213>智人
<400>3
ccagacctga ggtgctcaaa cgcggctcat tttggtgggc ggtggggaaa gggggagggg 60
gaaacgaaaa gacttttgat agactttacg aagaatccgc ttacttcctt tccagccagt 120
gttttttggt tttgtttata atattcaggc ccgcacccca cattccgtcc tgttttgaga 180
ggaggaggga agagaaataa acgtggcagc gcatagaagg ccagcaggga ggttgggaaa 240
gggtaaccag gaggcggggg tggggcatgc aatttggtaa caatctgggc ggcacactcc 300
caccctgact ttccccacca ccgccccggc accctcccat cccccagccg accctctgtg 360
atttgggagt gctgggaaat gggtgtacca gctgctgttg gagaggtggc gggtttggcg 420
ctgtctgggc ttcacgggag gtggggggga aggggcggac cctgagagaa tctggtatta 480
aaccgccttg ttaactcgca gactgctttc cagacacctc cggcccacac agccgttcac 540
cccccgtctt ttcagtcctg gaaaaggaat tcgggtatgc aggcgggaga aatggcggtt 600
gttgggggga tttgtgggaa gtgggaggta gagcccatag cagagaaatc gtggaaaatc 660
tcgaccctga acccgaaaag gcagacgttg aggcccctct tctgcaggct aacgctaggc 720
ctaggggctg gggagcgaaa gatgggtgat cctgggaggg gaacactgaa ttgtttggca 780
ggagtccccc ataccgcgtc ccatccagct tttgctgcac cctcgccccg ctcccctccc 840
gcttcgttgc aggagaaggg gtgtggcggt gtgtcctgga gaaatggcgg acgggggcgg 900
ggcaaagcgg aaggagggat tgagtgcctg gggagcctgc gcaggaggag gattgaggtg 960
ggaggggtgg ggtgagaaga gttgaaggaa ttgagaggta gaatcatttg acattctgat 1020
gtgcaaacac gaaaaggcag ttactgagac ccttgtcctg gatgctgatc catccaccag 1080
gctttcattg tctaacgtcg acagtctata tttctgctct tcagtctgtc cttaggatga 1140
agctctaact gaactgaagt aaggagaaac agccttgaat ctttggaggg tcagtgctgg 1200
<210>4
<211>1200
<212>DNA
<213>智人
<400>4
cccagagttg aatcattaac tggaacctaa tccgaagaca ggtgtttaaa actgtcatgg 60
ttacagccat caaattacag gaggttcaca cacagcagtc agcaatggtt tgggaatatt 120
aaataaatgt gtttctctaa caggacaaga caggatcatt tatttatgca acttaaaagc 180
tgtcccagaa ggagaaaaaa gtagcgtatt atttgtccaa aataaacaag attgaagaac 240
tgaacatctc tctgtggatc aatttacaga tcacatggaa ataggcttat cttattgaga 300
aatattccat tttagatgtt caaatacctt agcatatttt aaaaactatt tcctatgtga 360
ccaaaagaat tcatgttcta ttcggtaaaa attaaccaaa attaacggtg ctttccaatg 420
gacgcaggaa accttttttc tttacaaaat atgcccaccc tttttttgtt gctacttccc 480
acattgaatt cttgttttac tgaattttct tactataaaa ataaagcatg atgatagttt 540
tgaaaacaaa acagaagtat ttgagaagta cagaccccac tcccactcct tgtctccttt 600
ctgacactct gccccttaac tatactggaa cagggagtca actgcaagga aaatcctggg 660
gactaggggc tgaggaacta gaggtggaga gatggaagag tgtccagtag cccaggaaag 720
gatgaaacaa ttccccaaca aaaaagtaaa aattttcagt agccctccga gaagatgcag 780
cccctcccag gtaaccagag aaaggcaaat tgtgaaagca gggagaaggg gctactttag 840
gcctccagga ctacaaagac aaaaaaatga gtgacaggac ctgatgtggt ggggtgagat 900
gggaatggaa gtaaaggagg gggctcgtac tcttggtggg agtggaaatt ggggacccaa 960
gcttactggc gatgcagccc tcacgtgacc aggagctgac gtgggcaaag gtacttaaag 1020
ccctgaccgt cgttctccgt cctcctctgg gtaccaactc tattgcgcag ctcgctgccg 1080
tgcgtttaac ccaggcgagg aggaggagga gaaaattccc ccagattcgg gcaggtgggt 1140
gtgagggtgg gcacagtctg ggacccctga atagggtaat ctagggatgc gggagtcgga 1200
<210>5
<211>1200
<212>DNA
<213>智人
<400>5
tgtttaaaac tgtcatggtt acagccatca aattacagga ggttcacaca cagcagtcag 60
caatggtttg ggaatattaa ataaatgtgt ttctctaaca ggacaagaca ggatcattta 120
tttatgcaac ttaaaagctg tcccagaagg agaaaaaagt agcgtattat ttgtccaaaa 180
taaacaagat tgaagaactg aacatctctc tgtggatcaa tttacagatc acatggaaat 240
aggcttatct tattgagaaa tattccattt tagatgttca aataccttag catattttaa 300
aaactatttc ctatgtgacc aaaagaattc atgttctatt cggtaaaaat taaccaaaat 360
taacggtgct ttccaatgga cgcaggaaac cttttttctt tacaaaatat gcccaccctt 420
tttttgttgc tacttcccac attgaattct tgttttactg aattttctta ctataaaaat 480
aaagcatgat gatagttttg aaaacaaaac agaagtattt gagaagtaca gaccccactc 540
ccactccttg tctcctttct gacactctgc cccttaacta tactggaaca gggagtcaac 600
tgcaaggaaa atcctgggga ctaggggctg aggaactaga ggtggagaga tggaagagtg 660
tccagtagcc caggaaagga tgaaacaatt ccccaacaaa aaagtaaaaa ttttcagtag 720
ccctccgaga agatgcagcc cctcccaggt aaccagagaa aggcaaattg tgaaagcagg 780
gagaaggggc tactttaggc ctccaggact acaaagacaa aaaaatgagt gacaggacct 840
gatgtggtgg ggtgagatgg gaatggaagt aaaggagggg gctcgtactc ttggtgggag 900
tggaaattgg ggacccaagc ttactggcga tgcagccctc acgtgaccag gagctgacgt 960
gggcaaaggt acttaaagcc ctgaccgtcg ttctccgtcc tcctctgggt accaactcta 1020
ttgcgcagct cgctgccgtg cgtttaaccc aggcgaggag gaggaggaga aaattccccc 1080
agattcgggc aggtgggtgt gagggtgggc acagtctggg acccctgaat agggtaatct 1140
agggatgcgg gagtcggagg ccgcgggtgc ctcggtctcc cccactcctg gccggctttc 1200
<210>6
<211>1200
<212>DNA
<213>智人
<400>6
ttacaggctt gagccaccat gcccggccaa gatgtcagtt ttttaatggt gtgcaacgtc 60
cgtttctttg atagttggaa agcgtggcag gtattagagg gcgaatgtat atttaagaaa 120
aacaagataa gtcttcatct gtagagtatt aatttttctg tgatccttta tctcagacgc 180
ctctcctctg aaggtcactg ctcaagctgg gcagcccctt ctaagaaggg atgctgcctt 240
ggagttggag atgaggttaa gatctacgtg cgggtaccag tttcagtaat aactggatcc 300
ttctctaggt ctaggctgga acgtctcaag tgaaggttat tggggggcag gggtttgggt 360
ccacccaaaa aggcttgacc cataggactg aaatcaaatc ttgagctagg ctggcttgcc 420
acgtaaccac agaaacagta atttaagcaa taaaatgaaa gctcgagcgc tggtccagag 480
ctggggttgg gacagctact gcactcaggt ctccaggtgc atgtagggag aagagcagcg 540
gatcccttgc agacaatggt gggagcgagc tcttcaccct ggggtctccg aagcccattt 600
ttagcgtcca gaggtgtgct ttcgccatct ccttctgcgg tggctgcttg cagggcgcat 660
tcccattgct gctgtctctg ttcctaagga agatcaaagg atcccagaaa acccagttcc 720
agagctcagt tcccgggact agagggtacg ctcggccaga tggctggggg tgccgctggc 780
cttggcgccc ccgccgtccc cgcgcggtcg cccaccccgg cccgacaagc agcttgggcg 840
tccagcccgg cccggtccct gcagggaggg agcgcaggag ctgggggcgg ctctcccggg 900
gcggggctcg ctccacaagc gccaggggcc gcgcggggcg tgggcgtggg cggggccggg 960
ggcggggccg gccttggctg ccgcggcaca ggcggcggcg tctccagggg gagccaaggt 1020
acgtaggcgg cgtccgcctc acccgagcat ccttccccgc cggtggccgc ccgcccgcgg 1080
cccgcgctcg cagcctcccg cctggcggtt gacttctttg tgtcgtattc tctgcctgcg 1140
ccctgtctct gcaggacctg ttcgttcttc tttgggctat aagaaggcag aggatgagat 1200
<210>7
<211>1200
<212>DNA
<213>智人
<400>7
ttctgtgatc ctttatctca gacgcctctc ctctgaaggt cactgctcaa gctgggcagc 60
cccttctaag aagggatgct gccttggagt tggagatgag gttaagatct acgtgcgggt 120
accagtttca gtaataactg gatccttctc taggtctagg ctggaacgtc tcaagtgaag 180
gttattgggg ggcaggggtt tgggtccacc caaaaaggct tgacccatag gactgaaatc 240
aaatcttgag ctaggctggc ttgccacgta accacagaaa cagtaattta agcaataaaa 300
tgaaagctcg agcgctggtc cagagctggg gttgggacag ctactgcact caggtctcca 360
ggtgcatgta gggagaagag cagcggatcc cttgcagaca atggtgggag cgagctcttc 420
accctggggt ctccgaagcc catttttagc gtccagaggt gtgctttcgc catctccttc 480
tgcggtggct gcttgcaggg cgcattccca ttgctgctgt ctctgttcct aaggaagatc 540
aaaggatccc agaaaaccca gttccagagc tcagttcccg ggactagagg gtacgctcgg 600
ccagatggct gggggtgccg ctggccttgg cgcccccgcc gtccccgcgc ggtcgcccac 660
cccggcccga caagcagctt gggcgtccag cccggcccgg tccctgcagg gagggagcgc 720
aggagctggg ggcggctctc ccggggcggg gctcgctcca caagcgccag gggccgcgcg 780
gggcgtgggc gtgggcgggg ccgggggcgg ggccggcctt ggctgccgcg gcacaggcgg 840
cggcgtctcc agggggagcc aaggtacgta ggcggcgtcc gcctcacccg agcatccttc 900
cccgccggtg gccgcccgcc cgcggcccgc gctcgcagcc tcccgcctgg cggttgactt 960
ctttgtgtcg tattctctgc ctgcgccctg tctctgcagg acctgttcgt tcttctttgg 1020
gctataagaa ggcagaggat gagatgtccc gggccacgtc tgttggagac cagctggagg 1080
cacccgcccg caccatttac ctcaaccaac cgcatctcaa caaattccgc gacaaccaga 1140
tcaggtagga gaaggcggcc ggctcgcgcg gaaggcggtg gagtcacagc tgggaagggg 1200
<210>8
<211>1200
<212>DNA
<213>智人
<400>8
ttgtcagtcc ctaatgttaa tttaggttaa aagaaatgta atgctcgcat cagtaaaagc 60
aaggtcagac tttcacctga acagttttat ttttgttttg ttccgttttt actccgaggt 120
cagaatgtca tcaggcacaa taaagatagc ttcttatctt catgggattg tgcccagaaa 180
gaccaagcac agtctaaaca ttacgcgata agaaaaaaca aaaaatagat caagtgacct 240
tggacaagtc atcttacctc tcgatggttt tgttttatga aagaaggtgt gtgtgtgtgt 300
gtgtcgatgg gtgtgtgtgt gtgtgtgtcg atgggtctgt gtgtgtgtgt gtgtgtgtcg 360
atgggtgtgt gtgtgtgtgt gtgtgcgtgc gggggttgag aaggttgctg ttaaggttcc 420
ctagggctac ctgcagcttt aatatgcgta gttagaatgt caggcaggtt gtggagagtg 480
gggggctgga gacccccgac ttctctgagt gccaagccac acatcagaca ccttggaaat 540
aacccttcca cgaagtccct acacagatcc caccaggctg ggcacggaag aacagaaact 600
gcgaaaagaa agggactgga tgagtcctgg ggaatcacag cgcctccact tgcacaggac 660
aagtgacagg caggtaaata ggtagcagac aggcagagac tccgagtccc ccaggtgcac 720
ccctctcctg gaagagcccc cgaaagtaca ggcccaatct cccaccccac caagccctcc 780
ccatcgcctt ccccgacacc taaaagcccc ggtcctgcgt aatattgcgg atccctccca 840
gcctcccgtc cgctcctcct cccgcggggc tccgctcagg gccggtcccc cgcccccacg 900
ccgcagcccg ggccagcggg gcccgccgcg gtggcgttcg cggatgctgc cgcattggcc 960
gctgcggcac ggacggcgca gcctcgggcg cggcccggca caggcgccgg cggtccccgc 1020
cagctagcag cccggcgagg cgctggccca cccatggtcc tcgggcggcg gcccctgcgc 1080
ccagccctgc gcgtagcctc cgtctctcgc ccggggccgc cgagcccccg acacgggcga 1140
gatgctgaac ggcgcaggcc tggacaaagc tcttaagatg tccctgccgc ggaggtcgag 1200
<210>9
<211>1200
<212>DNA
<213>智人
<400>9
gccaaagtga tatattaagg tcaccacctt ggtcacctgt ccatctatat ttttggagta 60
agcaacagaa ttaggagtct gaacatagga attaagaagc tctcgaatat aacagtggaa 120
gaccagcacc ttcccaacct cttgtcaggg cagggatact ctatctctgc gtcactcaac 180
ctgccttggc ctcacagctc ttccttttgc ttaagtcttc aaaccatcaa cagtgatagc 240
cactaatttt agcaggtggc attagttgtc agcaaatgtt ttttcatatt taatgaatgt 300
ttattataat agaataaaat agaaatgttt attaataaaa cttgaaattt gtcccagaag 360
gataaaaacg tagattattt acataaaatg gccaagatct gacaacagaa ctgtttcctg 420
aagatttact tcacagatta ttttgaaaac accaactgtg ttcaggaaaa ttttctctcc 480
tttttttcat aaaattttca aacaagtgag aatgctctaa aaatgatggt gtggagccta 540
gagaaaatgt tttctgtgtg ctatagatga acataaacta tatatatata ttactttccc 600
aggttgaagt gtttctttca aaaataaaat ttgattattt tcaatttttt gagggatgct 660
gatttttaaa aaggaaataa agagaaatta ttaggaagca tatacacagc cagtgagaag 720
aggaaagaag aaaaggccaa ggccagagga agggggtttg gggtggggga aaggaagggt 780
acagaccctc ccaaataacc gaagatgggt aaactccaac cgcaaagcga tgatgccact 840
tgtgggccct cagattggag aggacggaga tgagtgacgg ggctgtgcgc actggggcac 900
cgcgcacaga cgggaggagg ggggtgtctg tgtgttccaa aggggggagt accagttaac 960
tggccgccgg cccgtggggg ttggtgagaa ggagggtgag cttggcggtg acgcacggcc 1020
ctcacgtgac cgggagctgc agagctacgc agccttcggt gcagtcgtca ctcgtgtctc 1080
gctaccagct ccccgctgcc ctgcgctcgg cgggctggca tccggcccgg gggaaagcgg 1140
accaggtaag ggccccgggg cccgcgcgcc ctggctaggc cagcagaggc tcaccgaccc 1200
<210>10
<211>1200
<212>DNA
<213>智人
<400>10
ttgacacttg gatttggatc aacaatgctt tcaagaagaa agacttttga tcaaaagcgg 60
gaaatgagaa agcgactttc ctctgaaaag tgcctcccag tcccgaggct gcgaggcccc 120
cacgccaggc tggctcccac ggaagccggg cacccacccg gcccgaccaa gcgccactcc 180
gccccgtgga cggggcgtcc caccccgggg acgcccgccc cacaccgcgt ttgcaccccg 240
gaggcccctt gccgcagagg cggacggcgc gcctctcccg ggcccctggg gtccgcgcct 300
ccctcgggca gactctttcg actctgctcg agcctccgct tcttcctgcg ggcggacgcc 360
ccggacacaa cgggccccgc tgttcacgca ggggcgcccc ggcggggcgg gcaaagaccc 420
ggggacgcgg tcccgtcccg agacgctcag ctccggccca ccgctcgcag ctcccgcccc 480
gggcgcaggt cccgacccca cgggccgtct cggagccgca gcggccgctt ccctgcacgt 540
cctcacgccc cccgcacgga cgccgccagc cccgcgcctc agtttcccca ctagcaggat 600
ggaaagacgg gccccgcccc gaagcgtagc ggcgtctccg tggtagccag tgcccagaga 660
gtccgccggt cccaccgccc cttcaaagga gaacccggcc caccgcccgc cgcggcggcg 720
accgcgcagc ccactcgtca cgcggcccgc ggcgtccagc ccgggccggc tcacctcagg 780
cggtcgctgc cgccctcgcg cctgcgcgcc cctcgccccg cccctctccc cgcccgcgtc 840
ccgcgcaccg caggcctctg cccctcgccc accgcaggac ccgccccgcg cacgcgccgc 900
acgtgccaca cgcaccccac gcccctgcgc acgcgcaggc cccaagtcgc ggccaatggg 960
cgacgcggcc gcagatccgc ccggccccgc cctgccctgt gagttcctcc ggccgggctg 1020
cggggctccg ctcagtccgg gagcgcagct gggccgcggc gctccgacct ccgctttccc 1080
accgcccgca gctgaagcac atcccgcagc ccggcgcgga ctccgatcgc cgcagttgcc 1140
ctctggcgcc atgtcgcaga acggagcgcc cgggatgcag gaggagagcc tgcagggtga 1200
<210>11
<211>1200
<212>DNA
<213>智人
<400>11
tgctttcaag aagaaagact tttgatcaaa agcgggaaat gagaaagcga ctttcctctg 60
aaaagtgcct cccagtcccg aggctgcgag gcccccacgc caggctggct cccacggaag 120
ccgggcaccc acccggcccg accaagcgcc actccgcccc gtggacgggg cgtcccaccc 180
cggggacgcc cgccccacac cgcgtttgca ccccggaggc cccttgccgc agaggcggac 240
ggcgcgcctc tcccgggccc ctggggtccg cgcctccctc gggcagactc tttcgactct 300
gctcgagcct ccgcttcttc ctgcgggcgg acgccccgga cacaacgggc cccgctgttc 360
acgcaggggc gccccggcgg ggcgggcaaa gacccgggga cgcggtcccg tcccgagacg 420
ctcagctccg gcccaccgct cgcagctccc gccccgggcg caggtcccga ccccacgggc 480
cgtctcggag ccgcagcggc cgcttccctg cacgtcctca cgccccccgc acggacgccg 540
ccagccccgc gcctcagttt ccccactagc aggatggaaa gacgggcccc gccccgaagc 600
gtagcggcgt ctccgtggta gccagtgccc agagagtccg ccggtcccac cgccccttca 660
aaggagaacc cggcccaccg cccgccgcgg cggcgaccgc gcagcccact cgtcacgcgg 720
cccgcggcgt ccagcccggg ccggctcacc tcaggcggtc gctgccgccc tcgcgcctgc 780
gcgcccctcg ccccgcccct ctccccgccc gcgtcccgcg caccgcaggc ctctgcccct 840
cgcccaccgc aggacccgcc ccgcgcacgc gccgcacgtg ccacacgcac cccacgcccc 900
tgcgcacgcg caggccccaa gtcgcggcca atgggcgacg cggccgcaga tccgcccggc 960
cccgccctgc cctgtgagtt cctccggccg ggctgcgggg ctccgctcag tccgggagcg 1020
cagctgggcc gcggcgctcc gacctccgct ttcccaccgc ccgcagctga agcacatccc 1080
gcagcccggc gcggactccg atcgccgcag ttgccctctg gcgccatgtc gcagaacgga 1140
gcgcccggga tgcaggagga gagcctgcag ggtgaggcgg aggaggcggc gcgggagccg 1200
<210>12
<211>1200
<212>DNA
<213>智人
<400>12
ccaacaattt gagcggccaa gacaggcagc tcacttgaag tcagaagttc aagcctggcc 60
aacatggtga aaccccgtct ctactaaaaa tacaaaaatt agccgtggta gcgggcgcct 120
gtaatcccag ctactcggga ggctgagaca aggagaatcg cttgaatccg gaaggcggag 180
gttgcagtga gccgagatcg cgccactgca ctccagcccg ggcgacagtg cgagactccg 240
tctcaaaaat aaaaataatt agtaaattaa ttcattaatt taagaaaaaa agcgcaatct 300
tcttccaaag gcgatcccaa ggctgttgga ggctgaaacc gctaagtcgc cccctaccgc 360
gcgggtggct tcgtcccgga cccctccaga ggctgtgcca ctgctggagg tgctcagcgg 420
ggccgggacc cgcttggggc gccgtccggg gcgagcaccg gagcccgact gggctgaatg 480
gcaggtcctg accaagccac ccgcgcggcc ccgcccgcct ggcgggatga gtgacggcgg 540
caacaggtgc agagcggcgt ccgcggcttc tcgggagccc ccgagttttg cgagtcaggc 600
cccgagagtc agagtttgac tctagaacct tcttcgcttt acaccagtct tcggaagtcg 660
cccgtcaacc ggcttcttct acctcagtaa agccttaagg tcacctcaac ctctcgaaac 720
ccaccagtcc cagaggccga ctcttctcaa gtggaggaga ggggaaggcg tgcatggagc 780
tttgcctgac cgctcgctct ctcctcccca gccgtctgag agaaggcgag aggggtccca 840
gaaccgagcc ctcgctccgc acgccccacg cccgccccgc tgtgccgtgc gctctgcccc 900
tgagacgccc cggctcggag tcccagggcc acagccgaaa ctcgccctcc cgcgcccctc 960
tccggcttgc agcgcccgcc cgcaccgcca cctgccaccc gaggcgacgc agtccgcttc 1020
tccccacccg ccaggtggca ggttcagggc cggggtccga gcctgcttcc ctgcagctgc 1080
cacagccacc ctcgccgcca gggggcgaga gtcccaggca ggacaagcag cgctgctgcc 1140
ttggcgtgaa ggtggtttca aactttaggc ttcttttccc taccccgcgt ctctgaagag 1200
<210>13
<211>1200
<212>DNA
<213>智人
<400>13
gaggaagatg gaaaccgagt ccgggccggt gagtacggcg atcagggccc cagggcgcgg 60
gatagcgggg agaaggagca gcgtggagcc tgtccctgag ggcttggagg ggcgaggtga 120
aggccccaaa cgctcgctat ctggttggga agaaacgtgg ccaggtgccc catcgaccgc 180
tgccaggagc cacccgcccg cagacctcgt ctggctgtgt catgggggtc agaaaggcgc 240
cgccacgggg cctggactgg gtgtagacgg gccaggggac ctcaggcgtg gatgtttcgg 300
gaggcggcgg gctgccaggc acccagcgaa gtccgagcag gtaaaccgct ttcccgccga 360
aattgggcta ggcagcgtct ttgacgctcc ctgcggccga actcgaccca gccgcccaag 420
gcgaggagtt gccagggcgg tcgacgcctc cactccccga ctggtcagcg aggaccggaa 480
ggtctgagag acctggcagg gcccgcctgt ggcccaggcg ggacccggac actctagccc 540
tggctgtgca cccaagccag tcagggtgga cttggggaag tgaaggagga ctgcccgcac 600
aggcccgagg cgcagcggca acgtgccatc ccgccccgcc ccgtcccgcc gccagcagcc 660
aatcagggag cgccgcgcga gggtggggac cagctgcgca cgaggccagc ggcggggtcg 720
ctgccgttga ggcttcccgc cactgctgct ggcggatttg tggggcaaaa tttctcgctg 780
gctagccttc ttttccctcc cgcactttgg tggggagggg gtggatcctc gtttcggtgc 840
ccaagttcac gatgacccga gagaactcga ggaagttgtc gccgcggcca tttcccccag 900
tgccgcaact tgctggcctt ggagggggag gagcgccgag gcagtgactg cgacggttag 960
cccgcccgtt cctgctgtct tcgtttgcaa aatagatgct agatctcgag gttgattctc 1020
aaggggaggg gccagtgagg gcacattgct ttggaggagt agtttaataa actctctagt 1080
gctggaagtt ttagcaaacg gaggagcctt caaacccggc aacagtcccc atctaggtgt 1140
ttccgtaaca catgcggaat tattgctagt ggaatttcag gctttctttg ttgtttaact 1200
<210>14
<211>1200
<212>DNA
<213>智人
<400>14
ggattttgta tatgtcatca gctgttgtga ccttccaacc catgagaatt ttcctcatgc 60
ctgaggattc acttaaggct acactttcag atccagagat atctttcttt tcctcttggc 120
tgggtcagtc tgactttggc tgcatgatca cacattatta gcaggtgcta ccatttttag 180
gttagaatat gtgactttct taaagtaaaa aaaatcctat agtcctctag cttatcaatt 240
cattaagtta aactttatat accaattttc ttaaatggag gaatgccttt attaatatgc 300
agcatctatg tcattactaa attactatac caacaaagat gaaataattt attgcccaag 360
ttggtctccc ccccacccaa cctttttccc cagttttgtg tggaagtttg atcaggagct 420
ttttccatgg aggttttcag cttccttagt tctaggcaca aagttatgat ctttccctga 480
tgctgaccac cttaggatga tatctgatta ttagtcttgc tactgcgcta ttaagtgtca 540
cttatttcta aggaaatgaa ttgagggtct tggacaggat aaggacagga atgttttatt 600
acccacacta cagatgttgg aaaacaaagc tgaaaactct tttaatttgt gtctatactg 660
acatctgaat gcttaaccca ttattgcttt tttttttggt ggtggtgggt agagatgggg 720
tctcactgtt gcccaggctg gtcttgaact cctgggctca agcgatcctc ctgcctcagc 780
cttccaaagt cctgggatta caggcatgag ccactacatc cctattattg ccttctttaa 840
aaatcttttc ttctctaaaa atctttttag atgttaatta acccatctgg ttgttgtttt 900
tcagtagaga aatggtcaga aggaacgaca ccacagaaga aattagaatg tttaaaagaa 960
ccaggaaaaa catctgtaga atctaaagta cctacccaga tggaaaaatc tacagacaca 1020
gacgaggaca atgtaaccag aacagaatat agtgacaaaa ccacccagtt tccatcagtt 1080
tatgctgtgc caggcactga gcaaacggaa gcagttggtg gtctttcttc caaaccagcc 1140
acccctaaga ctactacccc accctcatca ccacctccaa cagctgtctc accagagttt 1200
<210>15
<211>1200
<212>DNA
<213>智人
<400>15
taaggctgct tgtactctga taatcatgat tatggtgtta tttagagccc agcccaaata 60
cctgagccta aatgagtgaa agagcagaga gtgggcgttt ttttgttttt tttgttttgt 120
tttttgtttt tttgagacgg agtctcgctc agtagcccag gctggagtgc agtggtgtga 180
tctgggctca ctgcaacctc cgcctcccag gttcaagcaa ttctctgcct caacctccag 240
agtagctggg attacaggca cccaccacca cgaccggcta atattttgta tttttagtag 300
agacagggtt tcaccatctt ggccaggctg gtcttgaact cctgacctcg tgatccaccc 360
gcctcggcct ccgaaagtgc tgggattaca ggcgtgagcc accgtgcccg gcagagtggg 420
cgtttttaaa tgaagcagta ttcctttagt ttggtaaaat tgagctgaag ttacacacag 480
taacaccttg acttgttgct gacggtgtgc tttgtgggga tagttggtgt ctgatctcaa 540
ctgtggagaa acaggaagtt tctggattca tgctgaactc ccattccaca ggcgagtttc 600
acaaaagaaa aagtgctctg ttgcatacaa ttattcactg tgtgtctaca acgtggcaga 660
aattattatt cctaaaggtg accgaagaga gctatagttt atggggccag gagcaatgtg 720
tggaatggcg aggcagtgac aagacagcac tgccataaat ctcttacttt ctttccaaac 780
gagctctaat tttaagctca acgaccaaag acggagaggc agtcgctttg agctactcct 840
ggctatttgt tgggaaatca cctaaatccg ttcagattta gccagaaaag gggaaataag 900
tctccctcgc cggccaaatc atggcctttg tcgctttcgg ctccccattg gctgcggccg 960
ctgtggcccc gcctccttga gtggtgcgga gctttgtgat gcggagcttc gtgatgcacg 1020
ccccgatgcc tgcggggcta taaaaacgct cgcaagcgcc aagtctcctc aggagccgcc 1080
ggcaaggggg caacgaggaa gctcttaaga gcgcggccgg aaagcaggtg gggagaatct 1140
ggagaaaagg cgcaccctgc ggcctcggag accattatgt ctcagggagt ctctcgcagt 1200
<210>16
<211>1200
<212>DNA
<213>智人
<400>16
tggaaaatca gacaccagac ccctcacctg caacaattgc ctgatgcctg ttgacccact 60
cctcttcatc tctccctaac tcctgctatt ttcccacatg cagttacatt tcttccctgc 120
tatatcctaa ttttaatcag ttgagaagat ggatttgaga ctgatctctc ccccctaggc 180
tgtagcaccc aaataatgcc ttcttccctg acaataatgg ggtctcagtg actggctttc 240
tgtgctgtga accaccagac ctagaccaaa ctcctggcat ttctctaaca atttcccacc 300
actgaactaa gttataaatt ctgaggatgg atccctgttt cttcatttta agatggggat 360
taaaaggtac atcctagagt gttattgtcc gtgtaaaata gggctgtgaa accccctaca 420
cctatgcaca gataaactga tggccctgca aatgcccaga gaagtaacct tataaagatt 480
tagtgaatgt ttcccaccat tattggaaaa tctggctaag tcagtagctt tgttttcata 540
tacttagggg gaaaatcaac aaaaacttga tgccctgtta tttccttcca gtttcttctg 600
caactctagc tccaaagact gcagttcctg cagtattttt ttttttagaa caccaggaaa 660
aaaagaaaaa aaaaccatgc aaatgtacta tttcttcaaa cacaactagg aatgattgaa 720
cagctgggag aatatgaaga aaacccctca gagaaccaag ggcaagcagt gagttcagat 780
ctaggcacat ggccactagg aatggttctt cactgccacg tgggcagcca acagccagta 840
gctagagacc agcctcggtc ttcggcctgc gggttctgca aagtcaggct agctggctct 900
ccgcctgctc cgcaccccgg cgaggttccg gtggggaggg gtagggatgg ttcagccccg 960
ccccgctagg gcggggcctg cgcctgcgcg ctcagcggcc gggcgtgtaa cccacgggtg 1020
cgcgcccacg accgccagac tcgagcagtc tctggaacac gctgcggggc tcccgggcct 1080
gagccaggtc tgttctccac gcaggtgttc cgcgcgcccc gttcagccat gtcgtccggc 1140
atccatgtag cgctggtgac tggaggcaac aagggcatcg gcttggccat cgtgcgcgac 1200
<210>17
<211>1200
<212>DNA
<213>智人
<400>17
actcaagcac cagcaagcgg actcgaactc aaagggtttc agggtgtaga cgaccagagc 60
gcactgaggg gctccaggtc ggcccgctcc ggagccggga gagtaaccgc gtgcagggaa 120
aggcgcacgg cagcctcggt gcctcccttc cctccaccgg acgggtgact gactaggggt 180
gaggtcctca cctccaggct gcgcagctga gttctggaag gtactgtcct gggggtgtga 240
gtgtgtgggc cctcaggaaa ggtgcgaggg gcggatgccg tggtctaccc gagcttgcgg 300
gggtgcggtg gtcaagttcc ccaggaccct cgctggcgcc gcttgtcgac aacggggaac 360
agtgggcgcc gcgggtggtg gtaacttggc ccgggaagaa aacacatccc tttcccaaac 420
cggattcctc tgagcaaaac cagatggtgt catccgcatt ttacagctgc gtcaagagag 480
gcccaggaca ccaagagcca gctgtggcca gagccctttc actgacccag aacactggcc 540
ctcggaaacc tggagaactg cgagggcttt taatgcggct gagaagaaag tgaagacccc 600
gactcctcct ctctccttcg aaagagccga cacaggtatg aagaccagcg cctcggacgc 660
tccggggtag ggggccgacg ccccctccct ttcagaatca cgccttgctg atgctcagtc 720
ctgcccagtg tccacccccc acccccgccc ccagtttcct ttctagcccc tccggtcccc 780
aaagcgaact aagctagcgg cagcttctcc atcccggagg agactccaaa ctcctaggtt 840
tcccaccttg gagagtactg ctctggaatg cgcaggggag cggcacctgg aaagggttgg 900
gcggaagctt ctcggaccca gagggggcgg acacccggca ccgcgcgtgg gagggattaa 960
ctccacccca ctagaccacc tccccctctc tcccaggagc cacttcaacc ggttgtcgcc 1020
ccagtggccg ccctctgagc acgtgttact gccagtctgc gtcagcgttg ggtaaataca 1080
tgactggccg acgccgccgg gtggggctat ttaagagaca gccgcccgct ggtcctccct 1140
gaacttggct cagctgccgg gctgctccgg ttggaaacgc caagccagct gcgtcctaat 1200
<210>18
<211>1200
<212>DNA
<213>智人
<400>18
cctcttttcc gtttgcattt tgccccatat tagaatgcta ccatctaaaa ccgctccatg 60
aattagaaag tttaagttgt cagggactga atgtgtctgt tttccaacag tttctggcag 120
ttccctgctt ttatggtgta gtcatggtga aacctgagtc atctgaagat ggtggcagtg 180
ccagagagca ggagagagga gctgcaaaga agccagacag cgttgggcat caataactcc 240
tgggcaccac cggccactgg ccttcattct gacaggagag ccaacccaac cctaactgtg 300
ttcagagatt gctccaagct ttacagttct accaaattct ttctgtagca aaaatataaa 360
ggcatcttct taggtaattt tttttcaggg ttccaagtag caacacctaa cgtctgcagt 420
gcgagttctc ttcttctttt tttttttaag gtgataaatc ataacatttt cctggaaagg 480
aaagcagtag acctcatttt ttgttttaag gaaaaatagt ttttctgttt ccattcatat 540
acattaaata actacccagg aaatacgccc cggttttgcg cgcgtgtgcg tgcgtgtgtg 600
tgtgcgtgtg tgtgtgtgcc gtttctctaa aattctgact catagtctgg aggacaatga 660
ttgacttttt tccacttcac atagttgcta tgaatttctc ctcacaagga tgggcctgtt 720
tactcaccct gggcatcgtt ggtagagcgc tagtgtaaac agcctgagga acccggtggg 780
ccggggaagt gggcgcgctc tgttctccgc ggccagctgg gacgccgggc caggtggggc 840
cgcctgcgtt tagcaactgc tttctcaccc cctggatttg cgatgtttgc cacagcagcg 900
agaagcgcca ttgtaatggg gatgggaggg gtggagcctc caagtcctgt ctcaatttag 960
atctctcact ctgctgttag gcgcgcccat ttcagattac taaactcgaa ttaagaggga 1020
aaaaaaatca gggaggaggt ggcaagccac accccacggt gcccgcgaac ttccccggca 1080
gcggactgta gcccaggcag acgccgtcga gatgcagggc ccaccgctcc tgaccgccgc 1140
ccacctcctc tgcgtgtgca ccgccgcgct ggccgtggct cccgggtagg aacgtgggcg 1200
<210>19
<211>1200
<212>DNA
<213>智人
<400>19
atgcgtgctg aagtatgtag gggtaaaatg acatgatgtc tggaatttgt tttaaaatac 60
ttcagaaaag cggggagtag gtgaaataag tgtgacaaaa ccttaatagt tgttgaagcg 120
gggtgatggg tacacagcag ttcattatac aattctactt ttgtgtatgc ttgaaacctc 180
tcaattaaaa aaagagggta gagagtcatc aagataattt actaaaagtt tcctgtaatg 240
tccccagaag acccccctaa ctcacacaca cacacaccca cacacacact gccttttgag 300
aactttctct agaaggccaa cccaggcagt cccccaactg taaggaagac tcgtgtatgt 360
atgtgcatat gtgcatttcc ccagggaaaa acatccacag cttccatgac gagaggggtc 420
gtgacccctc cccgccaaaa gattaaggac ctgcgatcct acagaccgga gccctgtttg 480
aagtctgcgt tgcccctcac ctcaagctgg tcactgtgtg aagttggcct agaatccccc 540
ggcccctggg agcttgttcc tccgcctgta aaatggggct gcagggccgt ccacgcggcc 600
accggaagga caaggtgttc aggccgctag gccgctccct ggcaagcgat tcccactcgc 660
agcgcggcct cgaccctcgc ccaagacgcg ccctccgcgc ccccaccccc tccaggccct 720
ggccagtcca cctcccgctt ggggcggcaa tttgtctcct tttgaacccc ccgcccccga 780
cgggtttccc cctttgattc gcggcccgga ggcttccccc cgctttgaaa tgcaaacccg 840
cctcggctgg ggccgcgggc ggcccggagc tataaaaggc ctgggtgggg cgggcgcggc 900
ggcaggacag ccgagttcag gtgagcggtt gctcgtcgtc ggggcggccg gcagcggcgg 960
ctccagggcc cagcatgcgc gggggacccc gcggccacca tgtatgtggg ctatgtgctg 1020
gacaaggatt cgcccgtgta ccccggccca gccaggccag ccagcctcgg cctgggcccg 1080
caagcctacg gccccccggc cccgcccccg gcgcccccgc agtaccccga cttctccagc 1140
tactctcacg tggagccggc ccccgcgccc ccgacggcct ggggggcgcc cttccctgcg 1200
<210>20
<211>1200
<212>DNA
<213>智人
<400>20
aggcgctcat ttaaaattcc agtcttgctc ccgagggctt tggcctccat cttcaccttt 60
aacgaccgag ggctggtggc ggcggctcct tcctgctctg cgacaggtgt cgcttctgag 120
cgggagtttt gggcacagac atcgcagatc cgcaccaccc ctaggggtct gcatgggttt 180
cagctgcacc cagcctggag gggctttttg gaagggggca cgtgggcggt gggagcgggg 240
aagcaggtga ggggagcccg cctgcgcgga tttttctgct gtaaatcaga cccacagtct 300
ccagagcgtc ttttccccaa gtgtggaaca catttttctt ctaatcctct ttggagaggg 360
ggttaggaac gtgccgaggc cggagccggg agcggggtgg gtcccggcgc ctgtgaaccg 420
agtgggggag cgggccgcgc gctgccctga agaccctgcc tccgcgccct tgggggctcg 480
gggcccagcg ccttcgcagg cgagcggcgg cggctggctc tgcccggggt gcgcgggggc 540
ggtgtttcct cgcctccccc tgcgcccggg ctcgccaagc cccgactgcc cgctcggccg 600
tcgggtccgc gggcgcgcgg acgcctcgac ggctccccct gccggggcgc cccccggtcc 660
ccaccctcac ccggcggctc aggactagtc ccccaacttg ttctctgctg ttaactagtc 720
gcgctgccgg aacgatggga tggggttgcc acagcaacca gactggacgt cacaatccgg 780
gcatgtgtgc cgcccccccg ccgtgccgcc gtgcctctgg cgctgccgcc gccaccctcg 840
gccggctgcg ggactcgggc tgcggggcgc ggtgggagga gcgcccgggc tttgcgggga 900
gcaggctaag gcggccgaga gaaagggggg tcgagacggg ggggtggagg tttggggggg 960
tgggggggca ggcggccgcc atcttctcgc cgaggccgcc tcgcccgccg cgcgcgccgg 1020
tccggcagcg cacgggttaa ggctggcacc gcgcccggcg ggaggggggg cgcccacctc 1080
ccctcctccc cgcgccgggc atgcggggcc cagtgggcac cgaggaggag ctgccgcggc 1140
tgttcgccga ggagatggag aatgaggacg agatgtcagg tgagcggggc gcgggtgcgc 1200
<210>21
<211>1200
<212>DNA
<213>智人
<400>21
cctctcggcc tttgctgtca ccaaggccaa aggaaggctg gctgtgtggt gtaccttgca 60
cctccagaat gccttcaggt gtgatgtggc accacagatc tggtaggtgg aggaaggggt 120
gggccatttt acagatggga aagcaggctc tggaggcttg gatgagtttc cgaggacagg 180
tagtagcaaa gctgggacct gctatcccca ccagagctgt ctccctgaat cagtcacccc 240
cgaccctgtc cagtcagaca gcaccgcctc cttggagggc caaggctgct cccacccatc 300
tcagggcccg agtggtgtgg tttgtggctg ttgtatttct tgcctttgcc agccagcagc 360
tcactgtcac cctagcatct gtcagggccc ctgcagtgtg tctgtgggct gccagagatg 420
gggcctcatt gtcccagcct agacgcacgg tgcctgggtg cagccctgcc ccgggtgagg 480
gatggtggat ggggctgccg tgtccctggg ctccagcaca gggctcatgc tccctgagtg 540
cttggggatc acacagtgat gtgacctctt ttcagggggc aatgggaaga cctaaggtag 600
gggaagtcca gaatctcatg ttctgctccc tgctctgctg tcccttgccg agtgggcctc 660
agtttccccc tctgtcctat gcacatggca gtctcaccta cgctggctca gatattctgg 720
gtgccgataa gttcaccatt gagtgaaagg gccacgtggt ctcacagacc cccactgccc 780
atctcctgtg tgcatgaccc atgcggctcc tggggacggg gtggatgtca tggcgtcacc 840
gtggtactgt tctgacttgg gggcagtggc actgatggga gggagcctgc atggcagcct 900
gctgtcatgg gagcctcagg gtggggccct gcagctgagc cccaccttgg ggacccttct 960
ctgtccacag tgccccccac tgaagggcaa agtccagcgg attctacact ggaggtggac 1020
ggagccccct gcccccttca tggtggggct gccggggcct gacgtggagc ccagcctccc 1080
tccacctaag cccctggagg gcatccctga gagagagttc tttgtcaagt gggcagggct 1140
gtcctactgg cattgctcct gggtgaagga gctacaggtg agtgcccggg agggtggctg 1200
<210>22
<211>1200
<212>DNA
<213>智人
<400>22
cgacaggtgt cgcttctgag cgggagtttt gggcacagac atcgcagatc cgcaccaccc 60
ctaggggtct gcatgggttt cagctgcacc cagcctggag gggctttttg gaagggggca 120
cgtgggcggt gggagcgggg aagcaggtga ggggagcccg cctgcgcgga tttttctgct 180
gtaaatcaga cccacagtct ccagagcgtc ttttccccaa gtgtggaaca catttttctt 240
ctaatcctct ttggagaggg ggttaggaac gtgccgaggc cggagccggg agcggggtgg 300
gtcccggcgc ctgtgaaccg agtgggggag cgggccgcgc gctgccctga agaccctgcc 360
tccgcgccct tgggggctcg gggcccagcg ccttcgcagg cgagcggcgg cggctggctc 420
tgcccggggt gcgcgggggc ggtgtttcct cgcctccccc tgcgcccggg ctcgccaagc 480
cccgactgcc cgctcggccg tcgggtccgc gggcgcgcgg acgcctcgac ggctccccct 540
gccggggcgc cccccggtcc ccaccctcac ccggcggctc aggactagtc ccccaacttg 600
ttctctgctg ttaactagtc gcgctgccgg aacgatggga tggggttgcc acagcaacca 660
gactggacgt cacaatccgg gcatgtgtgc cgcccccccg ccgtgccgcc gtgcctctgg 720
cgctgccgcc gccaccctcg gccggctgcg ggactcgggc tgcggggcgc ggtgggagga 780
gcgcccgggc tttgcgggga gcaggctaag gcggccgaga gaaagggggg tcgagacggg 840
ggggtggagg tttggggggg tgggggggca ggcggccgcc atcttctcgc cgaggccgcc 900
tcgcccgccg cgcgcgccgg tccggcagcg cacgggttaa ggctggcacc gcgcccggcg 960
ggaggggggg cgcccacctc ccctcctccc cgcgccgggc atgcggggcc cagtgggcac 1020
cgaggaggag ctgccgcggc tgttcgccga ggagatggag aatgaggacg agatgtcagg 1080
tgagcggggc gcgggtgcgc ctggggccag agcggcgggg gcgccgagac gggccgggcc 1140
cagggcggag cgcgggcggc gggggcggcg cggccgggct ggcgcctcgc aggaggggca 1200
<210>23
<211>1200
<212>DNA
<213>智人
<400>23
gcatgaaatt gagataaaac atttcaacag actggacaga ctctgaacac tgttgaagag 60
aacattgata aattggaacc tggtgctgag gcattttccc agaatgcaat gtacagagac 120
aaagataaaa cagggagaac atggaagaca ccttgagatg ctccaacaat catccaattg 180
gagttgcaga agaaacagaa aaaatggtga agaagttgga tttgttgaga gtttgcagac 240
ctggagagaa atgtgaggtc tcagatctgg agtgcattct ggaatagcaa gcaagataaa 300
tataaataaa tgaacccgta gacacgttag aacctctagg tactttagac ctagtaccta 360
caaaataagg gcagccagat cgttctcaga cttcttaaca acaacaggtg gcagagacca 420
tggcaaaatc tccggtgcac tgagggaaaa tgtgtgctga tagttttata tccagctaaa 480
ctctctctcg agaataaagg gaattatacg gggtcatggg agctcagaag ggactgcctt 540
tcttttctta tggggaggag tgaaatcagg gaagacatca cagaggtgat gtttatgttc 600
cctaggcagt aagggggtgg gcattccagg aagagagtca ggtagtttgg aatggctggg 660
ggctgtgaag gagcactcgt cctgcagcgc cttgaataca gggcagtgag atggaactta 720
attctgtgtg gtgggagcag gggaggctca tgtcagagcc ctgatttagg taagtggctg 780
tggggctagg caggaggatg gattggctcc aaggggtgag gttggaagct ttgttcttcc 840
ccagagtcct gcattgggcc tgcctgggtc ccagctgtct ccccacctag caggcagctc 900
tctcctcccc tgcctgtggc ggggtccccg cccatggccc atggggcccc ttgctccttg 960
gcagttcctc acgtgcccgt ctcccctgca gatgaccaag atgctggacc tcctggagga 1020
cttcctggag tacgaaggct acaagtatga gcggattgat ggtggcatca ccgggggcct 1080
ccggcaggag gcaatcgaca gattcaatgg tacccccatc ctgcccaagg gttctgattg 1140
agactccttt ttggcctctt ctcccaggcc tggttcttag ccaggtcacc cagctggtgt 1200
<210>24
<211>1200
<212>DNA
<213>智人
<400>24
gaaatctacc tatttgtaac tccagggaag taaatgagat aatgtttgga agatatctag 60
tctaccagct gctcaggcgg ggggcgaagg ttctgttccc tgtcccttct ctatcaaatg 120
gctttaaaat cagaagaaag tattacgggt aggaaatggg actgcgaaaa aaatggaggc 180
tgattctggc ctaaaggata cttatctcta tacaaagggc ttctgattca aagaggcccc 240
gggattcaaa aacacaagca gagctacacc acgtggggtt tgggacgagc tgaattccgg 300
ataaagatgc ctgtaaagag gagttgatgc gaatccagaa aagcacttga aatgcccagg 360
ctttgcatgg cacattcccc aggatttttt cgcaccgcat ttagaggttt agacggagtg 420
agctcgaatc aggccaaaag ccttaggtta ctcctgggcg gcagcggggc agaggtcaga 480
tcaacaggtg tggaaggctg cgaggtgagg gaagaagcag gtgtcggtgg aggccccagt 540
tcctccggcc cagaggctcc aacgctgcta ttggtgttcc agcagcgggc ggaggggtcc 600
tgcccggcat ctgggcgcgc tgggcccaga gcccgggagg aggcagacgg aggcggcggg 660
tcagcggcgg gccagccccg gtgggcttcc gctcccctcc gccggcccgg tccggcccgc 720
cgcggaggat gcctggaggt tgacgtgaat ggcctgtggc tgggaagccc ccaggcgccc 780
tgcctagccc gggggcgggg ccgcctagcc gccggccccg gtggcgtgag ggctggggcg 840
ggggccgggg acctcgcggg gagggagcgg gagggaaagc ggcccccgcg gcccttcaat 900
tggccgcacc gcccctcggc gcagaggcgg gaggaggcgg ccctccattg gtcgggcccg 960
gcggccaatc ctcgaaggcc caggcggagg cgggggcggc ctgtggggaa ccgaggtgcg 1020
ggcggcgagc gaggcagccg ggtgcttcgc agcggagctc gaggctctgt agcacccagt 1080
tggacccagt cgcccaggca ccgcccgcgc cccgcggccg tctcctgcgc ctcccagagg 1140
agggagttcg agcatccccc gcggcggcca ctcctcgggg ccaggagcgg ggaagcgaag 1200
<210>25
<211>1200
<212>DNA
<213>智人
<400>25
gatctcaggg attgaaatct gtcctaggtg tgcaccagaa agtggtggca agagatgaag 60
cttcggagga ggctgacctc ggccaggatt cttaagtctc aaagtttcag ctttctcacc 120
cctcaacgga catgaaatct acctatttgt aactccaggg aagtaaatga gataatgttt 180
ggaagatatc tagtctacca gctgctcagg cggggggcga aggttctgtt ccctgtccct 240
tctctatcaa atggctttaa aatcagaaga aagtattacg ggtaggaaat gggactgcga 300
aaaaaatgga ggctgattct ggcctaaagg atacttatct ctatacaaag ggcttctgat 360
tcaaagaggc cccgggattc aaaaacacaa gcagagctac accacgtggg gtttgggacg 420
agctgaattc cggataaaga tgcctgtaaa gaggagttga tgcgaatcca gaaaagcact 480
tgaaatgccc aggctttgca tggcacattc cccaggattt tttcgcaccg catttagagg 540
tttagacgga gtgagctcga atcaggccaa aagccttagg ttactcctgg gcggcagcgg 600
ggcagaggtc agatcaacag gtgtggaagg ctgcgaggtg agggaagaag caggtgtcgg 660
tggaggcccc agttcctccg gcccagaggc tccaacgctg ctattggtgt tccagcagcg 720
ggcggagggg tcctgcccgg catctgggcg cgctgggccc agagcccggg aggaggcaga 780
cggaggcggc gggtcagcgg cgggccagcc ccggtgggct tccgctcccc tccgccggcc 840
cggtccggcc cgccgcggag gatgcctgga ggttgacgtg aatggcctgt ggctgggaag 900
cccccaggcg ccctgcctag cccgggggcg gggccgccta gccgccggcc ccggtggcgt 960
gagggctggg gcgggggccg gggacctcgc ggggagggag cgggagggaa agcggccccc 1020
gcggcccttc aattggccgc accgcccctc ggcgcagagg cgggaggagg cggccctcca 1080
ttggtcgggc ccggcggcca atcctcgaag gcccaggcgg aggcgggggc ggcctgtggg 1140
gaaccgaggt gcgggcggcg agcgaggcag ccgggtgctt cgcagcggag ctcgaggctc 1200
<210>26
<211>1200
<212>DNA
<213>智人
<400>26
gggatggagt attgcagcct ctcgccccac agacttgtga acagggcgtg gggacagaca 60
cccagctcct agggccatgc cacccccacc cctgcccgcc tctcgcagca cctttcctgt 120
ggatctgacc cccttccaga cacagaagta agccagcacc cagcagacac agggtcacct 180
cccagctccc taccaggcaa gagcgaccag ggcagggact gatactgccg aacccaggag 240
ccaggcccga cccagcctca ggtccagcag gtcccgcctg tccacctggg ccaggcctag 300
agcccgggag cccctggctg gtgggaggcc acccgcaacc caccccacac gcagctccag 360
ctcccccacc aggcggggcg actaggacag ggacagaacc cgttgaaccc aggagtgaga 420
tccggccccg ggtcccgctg ggccctcccg tccaccttgg ctggacctgg cgcctgggag 480
accttggctg gcgcgaggcc acgcccacca gacatgcagt tccagctacc ccaccagctg 540
ggcgaccagg acagggacgg aggctgctga gcccagttag aggcctgccc cccggggtct 600
gtcctgggcg ctcccccaag gacggacagg gcaggcaggg tccgggacga tggccgcaca 660
gtcccggccc cgtgttccca ggcccgtctt gctcctcgat gtgagggaga cccgggggat 720
gggacaggct gggccccgca gtgcctgact ccctgcaggg ctcccgggac aggggtccgg 780
cggacagccg gctgctcacg ggtgaggggt ccaagctggc attgcggcca ccttccggcc 840
cgggctctct tggggagggg cggggttggt gagaaccggt cacgtgctcc ggggctcact 900
cggggtctcc cagggccgga agtagggccc ctgtgcgcag gcgccctgag gatcccgggc 960
tgcccatctc acgccagggg gcggaacttc ctgcagcctc tctgcctccg catcctcgtg 1020
ggccctgacc ttctctctga gagccgggca gaggctccgg agccatgcag gccgaaggcc 1080
agggcacagg gggttcgacg ggcgatgctg atggcccagg aggccctggc attcctgatg 1140
gcccaggggg caatgctggc ggcccaggag aggcgggtgc cacgggcggc agaggtcccc 1200
<210>27
<211>1200
<212>DNA
<213>智人
<400>27
ttgcagcctc tcgccccaca gacttgtgaa cagggcgtgg ggacagacac ccagctccta 60
gggccatgcc acccccaccc ctgcccgcct ctcgcagcac ctttcctgtg gatctgaccc 120
ccttccagac acagaagtaa gccagcaccc agcagacaca gggtcacctc ccagctccct 180
accaggcaag agcgaccagg gcagggactg atactgccga acccaggagc caggcccgac 240
ccagcctcag gtccagcagg tcccgcctgt ccacctgggc caggcctaga gcccgggagc 300
ccctggctgg tgggaggcca cccgcaaccc accccacacg cagctccagc tcccccacca 360
ggcggggcga ctaggacagg gacagaaccc gttgaaccca ggagtgagat ccggccccgg 420
gtcccgctgg gccctcccgt ccaccttggc tggacctggc gcctgggaga ccttggctgg 480
cgcgaggcca cgcccaccag acatgcagtt ccagctaccc caccagctgg gcgaccagga 540
cagggacgga ggctgctgag cccagttaga ggcctgcccc ccggggtctg tcctgggcgc 600
tcccccaagg acggacaggg caggcagggt ccgggacgat ggccgcacag tcccggcccc 660
gtgttcccag gcccgtcttg ctcctcgatg tgagggagac ccgggggatg ggacaggctg 720
ggccccgcag tgcctgactc cctgcagggc tcccgggaca ggggtccggc ggacagccgg 780
ctgctcacgg gtgaggggtc caagctggca ttgcggccac cttccggccc gggctctctt 840
ggggaggggc ggggttggtg agaaccggtc acgtgctccg gggctcactc ggggtctccc 900
agggccggaa gtagggcccc tgtgcgcagg cgccctgagg atcccgggct gcccatctca 960
cgccaggggg cggaacttcc tgcagcctct ctgcctccgc atcctcgtgg gccctgacct 1020
tctctctgag agccgggcag aggctccgga gccatgcagg ccgaaggcca gggcacaggg 1080
ggttcgacgg gcgatgctga tggcccagga ggccctggca ttcctgatgg cccagggggc 1140
aatgctggcg gcccaggaga ggcgggtgcc acgggcggca gaggtccccg gggcgcaggg 1200
<210>28
<211>1200
<212>DNA
<213>智人
<400>28
ttgtgaactg cctgtggaca gggcaacatg gcagagaact gagggcagct tttataacaa 60
attaagagat ttcttaatat ttaaccctcc ttacattaac tgctcgtggt atattattct 120
ttttaaaaaa ttatttatac tttttgtggg tacataatag gtatacgtat ttattggata 180
catgaaatgc tttaacatag gcacacaatg cataatgatc acataatggt aaatggggca 240
tccattcccc tcaagcgttt atcctttgtg ctacaaacaa tccaattata cttttagtta 300
tttttaaatg tacaattaaa ttattttgac tgtagtcatc ttgtgctatc aaatactagg 360
tgttaataat cacatcatgg agaatggagt atccatccct caagcgtggt gcattactct 420
ttgaatatgc tgctctggat tgtatttgct aatatgtggg gcttctctat taatgttgca 480
aaatagggag ccaataatct ggttgagaga tgaaagcagc agcaggaaaa tgtgttcaca 540
gaacctcata cgagtggcgt ctagggccaa ggctccttga atgcataccc aagggctgat 600
gagaggtggg gacgagtgct gccgaaggac tcctcaacta ccagaactac gtagggcccc 660
taacatcccc tcggagcgag ctccccgcgc cccgtacacc accaggtctc cctggttcct 720
ctcctgctcc ccgtcccgct acctcaggaa actttagccc agcctctccg atacaagccg 780
gcctccttga gggctttagg cccctcttcg ccagtgtata ccccacgaca cgcctgcgta 840
ctagggacca cccggctttg tgggcggagt ccatgagagg gttggagccc cgctcgtggc 900
cccgcccacc caagcctagg ccggccttcg tggacacgca tttccggcga cgcctcggta 960
ctgacctctg cagagccggg tggagcccat tgacgtccag cgaagcgagg agcagcgatg 1020
gacggtcggg tgcagctgat aaaggccctc ctggccttgc cgatccggcc tgcgacgcgt 1080
cgctggagga acccgattcc ctttcccgag acgtttgacg gcgataccga ccgactcccg 1140
gagttcatcg tgcagacggg ctcctacatg ttcgtggacg agaacacgtt ctccagcgac 1200
<210>29
<211>1200
<212>DNA
<213>智人
<400>29
tcgaatctgc agtgagtgat cgcaccactg cactccagcc taggcgacag aggtcaaaaa 60
caaaacaaaa gaaaacaaac aaaaaaaaca tagcaaacat ccagaagact gtgtagagca 120
atgaatgtct ctcaagccag tgatcttttt ctcttcattt ttcacatcag gtgggtagtg 180
tgcccacttc gtaacaaggt ttgagggagg cacatttgac acaagagcat gaaaacccaa 240
tcacacttat gacttacaaa aggatcaagt cagtgatctt taagctgtgg gccattaaat 300
acattttgtg agccgagtgc agtggctcag gcctgtaacc ccagcactat gggaggtgga 360
ggtgggagga tcacttgagt ccaggagttc aagaccagcc ttgggcaaca tactgggaac 420
tcccatctct attaaatttt ttttttttaa ttttgtggat tacaaccatt tcaaaaacta 480
aaataagcgt aaatgtatca aaatgcagct tacatagcga ggataaatgc tgttttgtca 540
atctgttgtt tcaagttttt tatgtgtgga ttgggtcacc ttgtaacagt gacttacctt 600
tatgggtcac ggttgaaaac atttccggtg cagtggctga ctgtaatccc agcactttgg 660
gaggccgagg ctggaagatc acttgaagcc agaagccaag agttcaagac ctgcctgggc 720
aacacggcga caccccgtct ctatttaaaa agaaaaaaaa aagtttccaa ggcactgaga 780
tgccaggaac ccgaggtgtg tgtccagtag gggagggagc aaattgggcg tttggaaaaa 840
gtcccacgcc tggaaaggaa tacacagtgg gggggtgggg ggcggggcac atcgactact 900
tcaaggcaca ctcccacggt tcagaaaacc gattggctaa aactgggaaa gtcccgccca 960
caacgctcac tggccaatgg ctgcgtgaaa tcagtgcgaa gtgggcggga tagagagcgt 1020
gggcgggggg gctagcctcg tgcgggctcc ttaagtagcg gctgcgtggc ttccctggca 1080
cgctactctt acgacgtcac ggtcaggtgg tgcagagctg gacggcaacg acgtcggacg 1140
cgccccttct tggaacaatg tcccaccacg gaggagctcc caaggcctct acgtgggtcg 1200
<210>30
<211>1200
<212>DNA
<213>智人
<400>30
cctccagttc ggcattagtt tcttcctaat gtccactctg cccgaagtga caagcggggg 60
catgtggaga ctcagctcca ggttcctgga cgggctcagc cacccccaga aagctaatga 120
atgctcaacc agggcttcca gatgcccagg ggacagagca ggagatgccg gggaatgggg 180
ctttccttgc agttcaggag ggccctgccc caggcccaga agtagaaggg aaagcggctg 240
ttttggcggt aaacagtaat gtggggagtg ctgcagagaa aggcagtctt ggggtttcaa 300
gctggagagc agtcagctac actcaggacc tctggccatc cctgccttca cctgctgttt 360
ggcctgatcg tctaacttct ctgattctcc actacccact ccttattacg tttttgagac 420
ttgtcaaagt tttatattag ggctaactgg gacgcataca aatctggtaa cttcgccagg 480
gcgggaagtt aggaaggagc agagctggct gcaggtgtct ggtcctgacc actcctctat 540
gccacccttg aggagcttgc tgactttctc atgacgttct cccattccag gagctgcaag 600
tgcgttatcc tggctggagc acggtgtcaa tcacggcaga ctaaggccag cggtgatggc 660
ttgaatgcca ggctgggggc tgggattttt cctgaggatt tcacaggaca gaggttggct 720
tggaaagacc aaggtgggac tgaggaacat tccccctacc cccaacctcg gtgggctgtt 780
gcaagcctgg aggccagaga agacgggcct gggatgccgc gggcgcaggg gcaggcagtg 840
aaggagatgg ctgccttcgg tagagctggt cgctgaggca gaagaggagg gcgtggggcg 900
tggggcgtga ggtggccggc gccccggctg gccaatggcc gggctgcggc ccctccgcgg 960
ggcggggtgg gcctggtggg cgggcggggc tcggggcggg ggcggagagg gagcctggtg 1020
ggcgggcggg gcgcgtcttg cgggctccct cgggtaccgg cgctgccgca ccccgccgcg 1080
ctcccgcacc cgcggcccgc ccaccgcgcc gctcccgcat ctgcacccgc agcccggcgg 1140
cctcccggcg ggagcgagca gatccagtcc ggcccgcagc gcaactcggt ccagtcgggg 1200
<210>31
<211>1200
<212>DNA
<213>智人
<400>31
gcactacagc ctgggtgaca aagcaagact ctgtctcaaa aaaaaaaaaa aaaacaaaaa 60
aaaacaatta atgccctcgg gtaaactatg acgtttgtgc taacttttca gatgtcccaa 120
gatttgggtt gttttacaag gataacgaag ttcatgatga ggttaagcaa tcactgaagc 180
tagtgctaga aatttttttt aatttaattt tttagaaaga ggggtcttgc agaatttttt 240
atttaatttt ttagaaagag gagtctcgct atgttgctca ggttggtctc caactactgg 300
gctcaagtga tcctcacgag tagctagggc tacaggcaca ggacactatg ccaggcttag 360
tgctacaata ttctgtctat tttactttaa aatattctaa gtatgctcac tttggaaggc 420
atcaacatcc agaaatgcat tcctacatca agactctcaa gaaacgggaa ttactgtaag 480
ggcataccct tgagcaacca tcacactgca ctgaactctt gagaatattc tggaatatcc 540
tggaagcatc tctgcagggc agagaagtga actgccacag aaggagcagc tttggggaga 600
agaaatacag tttgcctctt acagtatttt tctacaccga gagctacatt cctcccgagt 660
tttaaatttg tggaccgttg aatatcactc cgcctttcat aaagttacaa ataccttccg 720
tcggtggcgg gaacagagtt tggaaaatta catgcctaag acttcagata agctaaatga 780
catacatgca atagcatccc atgaagaatt tattcaaccc aatccattgc atctaattac 840
ccaaagcaca gaaactctcc aaactgtgca ccccccaaaa ggagggaaaa tgcaaggttc 900
ctgctgcagt tcccgggaca cactgcgagc cgctttgtta caagtgtatc caatgtcccc 960
agaacgaggg acttgtgggg cgcggctcat cccagcgcca cttgctctgc agctcccaga 1020
ggtggtggtt gtgttacgaa ggctgaccct gccaatggcc gacaaaatgg tgcgcacccc 1080
caagtgctcg agatgcagga accatggctt cctggtgccc gtcaagggac acgcgggcaa 1140
atgccgctgg aagcagtgcc tctgcgagaa gtgctacctg atctccgagc gccagaagat 1200
<210>32
<211>1200
<212>DNA
<213>智人
<400>32
atatatatat gtgtttatat atataatata tattatattt gtatacacac acacatatat 60
gccacatttt ctttatccat ttatcccttg atggacactt aggttgattc catatcttgg 120
caattgtgaa tagtgctgca ataaacatga aagtacagac gtctcttcaa cacactgatt 180
tcaaatcttc ccagtaaata cccagaaatg agattgctgg atcatatgat aattctactt 240
tcagtttttt gagaaacctc catacaattt tccatcatgt ttgtactaat ttacattcca 300
ccaacagcat acaagcattc ccttttctcc attcttgcca acacttgtta tcataaaggg 360
aggtttgaga gaccataaaa caaaccccac ctcacaattt tgttagtgca agttctattt 420
ggcctattcc caacactaag cacacagtag gtggcaaata tttgttgaat ggatgaattc 480
tcatttttct ccatttgtgg aagcagacac ctcctcaaaa aaaaaaaaaa atccgaaaga 540
aaaggtaaag gaaacagttc tatgaatggg ggttaattta ctctcctagc attcacttat 600
tgggaaaaaa agtaacagca gtttctagaa ccctctggtc tctgagggag atgctgtgtt 660
cccctcctca gagaagaaga aaacgcacta gagagtggga gcatccccaa ggctgaagcg 720
catccaggac atcacatgtc aacgtgtcct ctctggcgtg gggtccccgc gagtctggga 780
aacgaggagc tggcaaggga gggcaagcgg gggcggcaaa gagggcccct ggagcagggg 840
gcgcggacct cgctgcgctg cgcgctctac cgccgggctc gcaacgctgg gctcagcgct 900
cgcgcctccc tcagctctct cctccgcccc ccttcgccct ccccctttcc ctccctttct 960
cctcctcctc ctgccgccgc ggccgctgcc ggacttcgcc agatcagacc cacggggctg 1020
ccctcccctg cgcactcccc tcgctgcccg ggcccggagc gcagcgcggc cgcacaggta 1080
ggagccccca acggggggtc gccccgagcg agcccagtac tcactgggcc gcgcgcggga 1140
gagtgaggtg gggtgagctg aggggtgttg agtacccgag aactgccctg gactgtgcag 1200
<210>33
<211>1200
<212>DNA
<213>智人
<400>33
gagaagctct gagacatgtg agaaggtcta gtattctact agaactggaa gattgctctc 60
cgagttttgt tttgttattt tgtttaaaaa ataaaaagct tgaggccaag gcaattcata 120
ttggctcaca ggtatttttg ctgtgctgtg caaggaactc tgctagctca aggtgagtat 180
actgggaaag ccttaacgtt ctagagaaca gagttttgca gccccacctc catcccccgg 240
ggtgtgggac tggggggcag gaaatgcacc gtcccctttg aaatggatta ctgttttttc 300
ctttcgaccc cctctttctg cagcctgctt tgtaggtgca gtataaaatg cacgctgaat 360
gtcttttgta tgtaaacagc gtagcaggat ggagtaacgt gaaatgcaat tctacagcag 420
tttttacgtc tttgctgcct cgttcgttgg ctaccgagaa ggttcaggag ggggagggga 480
gatgagaaag cagattggaa gttgagtatg gtggagcctc agcctctccc accctccttt 540
cctcgcttgt gctcactgct aaagttttgt tactttcccc gcagcagata ctaaacatta 600
gtttgtcctg tattttcttt gagattcaca atgttgaaag cccttttcct aactatgctg 660
actctggcgc tggtcaagtc acaggacacc gaagaaacca tcacgtacac ggtaaggggt 720
gatggaattt gaaataagta cggttcagcg ggattctgtg acaaaaaaag actttacaca 780
cccctgccag tgtatttggg ctatactctg ctgagggtga taaattaaac aacacttcat 840
tcatgcttca tatctaagat tcgttgtaaa ttgccccctt gatcctttca aaagttcatt 900
gggctcacca cctaagatag gaaccaacat gtaatcattt gtgcagggct aaaaatggga 960
tccgttcaaa aactaaaacc aaagaaagtt acatgtttcc aaaacattca acaaattaat 1020
gggtgtaagg aactggaaaa cctggactcc taccacatgc agataaaacc aatacgtgca 1080
gaataagact caagtcaagt aagaacgtta aacaccataa agacacatgg ccttctttgt 1140
gtacatgaca tgcattctca agtaagtggc ctttattgaa tttataaagg ctatatattc 1200
<210>34
<211>1200
<212>DNA
<213>智人
<400>34
cggctaggtc ggagcggaga gtcgcagcag ccgctccggg cagcttccca gtcccggtct 60
gccttgtctg tgcggctgca agtccccgca cccacactta agcctttcac ttctacccca 120
ccgctcccag acgggctagg cccggttcca gggactgccc ccaaccctgc ccccgggaaa 180
tccacaactg gttccctgcc caaggccatc tcggggcgtc ctgggccctg ggcgaggtcc 240
acggcgtgtg cagggggacg gggccagcgg ggacttcctt actgctagaa agtcattcgt 300
tcagtctctg gagacagtga cggagccctg ctgcggactg gacgttgggg accaagtagg 360
tccccgctct ccaggcatct ggggagccag ggaagaagcg agtgatagag ccacaaaact 420
ccccgcaaag agtatttcag agggggaagc gccataaaga caaaacaggg caaggtggca 480
gagggtggcg gtggcaggcg cgagtctgca gctcagcccg ggcgcgctgg acgcagacac 540
gtcgactctc ctaaagaagc aaccgcaggt cagcttagac ttcttttatt tcaataaaag 600
agcgttttcc tccatcttaa accgcccgtg gtgggagaaa aggtttccaa cctcttctct 660
ggctcccctc ggtcaattcc gagcttttcc aaagtccctc cgccgtccag gggctcgacc 720
ttcgaggtaa cgtgggggat cccgctggct ccctccggca ggcgggggcg gggaccggcc 780
gtgctcgccc cctagagccc cgggagaccg cgcgccccgt ggagcccgga gggggcggaa 840
ccctggggcg ggccctgctc ggtgaaggcg gggctcggcc gccctgtctg cgccgccatt 900
ggccgcgggc cccggactgg cgggctcacg tcaccggccg ggcccgcccc cttggcaatg 960
tcttcagccc gctgctctcc taacttaagc atttattcca ctgggataga agcggcagga 1020
gcagcgttgg caccggcgaa ccatggctgg gattttctat ttcgccctat tttcgtgtct 1080
cttcgggatt tgcgacgctg tcacaggttc cagggtatac cccgcgaatg aaggtaagag 1140
cgggacggcc tttctgtggt cggggacagc gaggggccat cgcgggtgag gggtcctcag 1200
<210>35
<211>1200
<212>DNA
<213>智人
<400>35
aaccctgtgg agataggcaa aataagtata accccatttt acagttgagg ccacccactt 60
aataaacaag tgacaaagcc aagtttccag tattcctcaa gtgttttcct ttcaggctct 120
aaattgctga cttaaatgtc atcattagag agagttgtct cctcggtaga agtacaaatt 180
ttgttccaga gtcaaatatg aagacttgat cagtggcctg gcgcggtggc tcacgcctgt 240
aatctcagca ctttgggagg ccaaggcagg cggatcacct gaggtcggga gttcgtgacc 300
agcctgacca acatggagaa accccgtctc tactaaaaat acaaaattag ctgggcatgg 360
tggcacatgc ctataatccc agctactcag gaggctgagg caggagaatc gcttgaaccc 420
aggaagctgt ggtggcggtg agccaagatc gtgccattgc actccagcct gggtgacagg 480
agtgtgaaac tctgtctcaa aaaagaaaaa aagacttgat cagcttatag cctttatcat 540
ctagtcttct attctctgga gagtcagtgg ggactcttcc gagttcttgt agccttttct 600
taaggcctat aggaagtcat ctgtgctgag cctgcacttt ctataacaga tggaaaactg 660
aagctcagac atcttaagtg gcattgactt agactataga gctagttagt ggggggccag 720
caccatgacc tggcccctac ctccagcagg cttcacccac ccttgcaccc ttgcaggaag 780
cacttagagg cttgaggttg ccagctgtgg ggggttgggc ctgtgcagtg cctctcagcc 840
gcccacgctg gtggggctct gcagtgttag cttcttgttt ctctattttc tacctaggtt 900
tcagtttttc acttgggttt gtttcccctt tgtctctggt tcagcttcct tttcctgttt 960
ggttttaagt aggctataaa aatcaagttg ctgtcttcag agggtctgtg gtcctctgat 1020
caacataggc tggtgggagt acaggactcg cctcctcagg gttccctgtg ctgccacttt 1080
tcagccatgg ccacaaggtg agtattggaa ccagtgcagg ggacagaggg atgtcaagag 1140
gaaacctaga atcttaacgg tgaatgggct gtagaaatta tctcaggtcc ccttagtata 1200
<210>36
<211>1200
<212>DNA
<213>智人
<400>36
cttttaaatt tgtttctctt cccctttttg ttaaagtaca aaacaaaaca ccttccccca 60
cttttcgaat agttttggct gtgtctttag gactggaagg aaattcagct caaatgaatt 120
actatattat gaacttaagt aagaattgtt gtgcattttg tacagaatgc aactcctagg 180
agttgacaaa tgtttgttaa gtgcatcagt gagcgacata ggaccttctc ctccctactc 240
tcttgtcacg gtttttattt aatcaaacat ttattattgt tcgatgctct taaatgccat 300
ttccttcagc tgattatttg tatgacagaa gagtcaatta agctattttg tcctaaaaat 360
tacgaaaacg aaatgtacaa ttgtgaagta aaattttgtt cctttgcaaa ttttaataaa 420
ttattgaagt ttattttttg tttcaaataa tctgggcttc agttctaata atggaaggac 480
aatgtgaagg cccagaattc agcatagcgc ctggcattaa taggaggtca gtacattttt 540
agtacatgtt tctcaaatag atcttaaaat ttcatttaag agcgtttcct cacgtcacag 600
tatgtctctg gcgttactta attttgaaaa acctcaacac agattctagt tttaggcaaa 660
gctcagaaaa tttctactta aggatatttc caaagcgaaa ggaagcgcgg agacgttcat 720
gactggcatc atctcgcacg tggttccgga aattctcggt aggatgccct acatctgctc 780
tccctccact aagaagaacc tctttgtgtg gcgaaagtaa aagtattagg gcttttaagt 840
tgcccagagt caaggaacac ggataaagac gctgggagat tgacatgcat ttcgaccaat 900
agcattgcag agaggcgtat catttcgcgg atgttccaat cagtacgcag agagtcgccg 960
tctccaaggt gaaagcggaa gtagggcctt cgcgcacctc atggaatccc ttctgcagca 1020
cctggatcgc ttttccgagc ttctggcggt ctcaagcact acctacgtca gcacctggga 1080
ccccgccacc gtgcgccggg ccttgcagtg ggcgcgctac ctgcgccaca tccatcggcg 1140
ctttggtcgg catggcccca ttcgcacggc tctggagcgg cggctgcaca accagtggag 1200
<210>37
<211>1200
<212>DNA
<213>智人
<400>37
gcacaggctg ccagctcagg ctttggcccc tccatccgct cctggcttct ctgtgggtgg 60
ccccatctaa gccaatgggc ccttcctggc tccacctcct ctctgctgtg cggccctggg 120
caggcagctg ccctgccctg tgcctttgct cttggctgcc tcacccctgt cctgggctgc 180
agggagaccc ctgggggtgg gggcaggcac actttgggcc catggctgct gctcagatgt 240
gaggtggtga ccaccaggcc atacgtctct ggacagggat gggagagact cagagagaca 300
cagagaccaa gagataaagt cagagggaga tgcagagacc aagagggaca aaccaaggga 360
gacagagaga tgacattaga tcagagatgg agaccccgaa agagacccag aaagggatcg 420
gtgtgggctg ggggaagaga caccccgggg gtcacacagt ggtcacaggc atcagagctg 480
ggctgaggaa aaggacaaac tgaacctgtt ccaaagctgg gggctcagta ccgtctgccc 540
aggcacatgc agcagcagtg gggctgcagg caggccccca gggtaggaag caaggcgggt 600
gggaggcagg gcctggcctc tgggcagttt tgtagccggg cccctcaggc cctcacaatg 660
tgcccaaggc tgctgggccc atcttccagg ggtgatcact gaggctcagg ctggctgagg 720
tggccggacc ccaacccctg gccctgccct gtgggcagca gtgccaggtc tggcactcag 780
aggttaggcc gggcgcaggg agggtgcggg ctccgcagcg agcgcgccgg gcggcctcta 840
ggagccgggt cagcgagtct gggctctgag cgagcggcgc cggcccggcc ccctctccgg 900
cgggcggccg agaccccgcc ccggaggcgg aggcggagtc aggggagggg gccgggggcc 960
ggctggtccc gcctctcgcg cctccgcccc gccccgcgcg cacacagcca ggggccgccc 1020
gggctctcga cgcgccgacg gccgggcgga cggacggacg gacgccgagc gcagtgcccc 1080
gcggtgagtg cacgcggccc ctcccgcccg gactcatccc cgtcggtccg cgcctcgcag 1140
ctcaggactc gggggcgctc ggacgcaccg acggctcggc ggaccctcgg acgcgcctcg 1200
<210>38
<211>1200
<212>DNA
<213>智人
<400>38
gcacaggctg ccagctcagg ctttggcccc tccatccgct cctggcttct ctgtgggtgg 60
ccccatctaa gccaatgggc ccttcctggc tccacctcct ctctgctgtg cggccctggg 120
caggcagctg ccctgccctg tgcctttgct cttggctgcc tcacccctgt cctgggctgc 180
agggagaccc ctgggggtgg gggcaggcac actttgggcc catggctgct gctcagatgt 240
gaggtggtga ccaccaggcc atacgtctct ggacagggat gggagagact cagagagaca 300
cagagaccaa gagataaagt cagagggaga tgcagagacc aagagggaca aaccaaggga 360
gacagagaga tgacattaga tcagagatgg agaccccgaa agagacccag aaagggatcg 420
gtgtgggctg ggggaagaga caccccgggg gtcacacagt ggtcacaggc atcagagctg 480
ggctgaggaa aaggacaaac tgaacctgtt ccaaagctgg gggctcagta ccgtctgccc 540
aggcacatgc agcagcagtg gggctgcagg caggccccca gggtaggaag caaggcgggt 600
gggaggcagg gcctggcctc tgggcagttt tgtagccggg cccctcaggc cctcacaatg 660
tgcccaaggc tgctgggccc atcttccagg ggtgatcact gaggctcagg ctggctgagg 720
tggccggacc ccaacccctg gccctgccct gtgggcagca gtgccaggtc tggcactcag 780
aggttaggcc gggcgcaggg agggtgcggg ctccgcagcg agcgcgccgg gcggcctcta 840
ggagccgggt cagcgagtct gggctctgag cgagcggcgc cggcccggcc ccctctccgg 900
cgggcggccg agaccccgcc ccggaggcgg aggcggagtc aggggagggg gccgggggcc 960
ggctggtccc gcctctcgcg cctccgcccc gccccgcgcg cacacagcca ggggccgccc 1020
gggctctcga cgcgccgacg gccgggcgga cggacggacg gacgccgagc gcagtgcccc 1080
gcggtgagtg cacgcggccc ctcccgcccg gactcatccc cgtcggtccg cgcctcgcag 1140
ctcaggactc gggggcgctc ggacgcaccg acggctcggc ggaccctcgg acgcgcctcg 1200
<210>39
<211>1200
<212>DNA
<213>智人
<400>39
cccgcccctt cccccggaga cgcgcccacc cggccaccgc tctcttccca ctcccccatt 60
acccgcagcc ctcactcccc gctgcgggaa ggggctgctt ggctgcctct gggggtcttc 120
agagctaccc tggtcccggg ggattggagg aggaggttac ctatcctgcg tcgtctttaa 180
tccgtgcacc actatccatc aaatagagac agatcctggg cctctcaaag acggatgatt 240
gggggtggtg attggcctat ccctaaatat ctaccacgca aggactcttg agagatccag 300
accccggtac agtcgaggga cctggggccc aaaaagggaa agcggctacc tctaccacac 360
agttgggaag cgcagtccta aaggagacgc aggttggaga ctccgctaag cggagaagcc 420
gcagtggggc catggcaagt caccttccct ttcgggccta ggaatactca ttcgaaagat 480
ggggggactg gagtgccgag tggctgtggc agccacgatt ggggtttgga aaccatcctg 540
aaaggcccgg ggagccagtc tcctggaact tctccctccc cattcccaca aaaaccaagc 600
gccctctcgg ccaattctca ccctctcagg acaaaaaagt gagatgagcc cgtcctttca 660
cctgcgagtc caagcccttg gcagaggcct gaaaagtccg aaaactccga gttcgggcgc 720
tgaggtctcc cgagccggtt cctgaactct ccgggcctca gtcgatcggg gtgcggaggg 780
ggccgacccg ggggatctcc aagcgccctc cccgccctga cgctgtgggg ctcctaccgc 840
gccgccacag ctgctcctac ctggggaggt gcgcccgggc cccggggggc gggcagtcgg 900
ggggcgggca gggaaccggt gccgccccac gcttcgtggc ccctttaagg aggggaagcc 960
ggcggaggga ggagccggtc cggtgtgtgc aggggagcgc ctcgccagcg gtccgcaggg 1020
ctggagaccc acgccgtgga gaggaccagc ctcaggtcgc cccgcctggg cccgcgcccc 1080
gacctcgctg cccccgcctc gcctctctgc ccgtggcgct tacggccacc ttggcctcgg 1140
gggcagggca tgggcggccc ccgccagatc gcccagcgcc agtactaact gccctcgctc 1200
<210>40
<211>1200
<212>DNA
<213>智人
<400>40
ggttacctat cctgcgtcgt ctttaatccg tgcaccacta tccatcaaat agagacagat 60
cctgggcctc tcaaagacgg atgattgggg gtggtgattg gcctatccct aaatatctac 120
cacgcaagga ctcttgagag atccagaccc cggtacagtc gagggacctg gggcccaaaa 180
agggaaagcg gctacctcta ccacacagtt gggaagcgca gtcctaaagg agacgcaggt 240
tggagactcc gctaagcgga gaagccgcag tggggccatg gcaagtcacc ttccctttcg 300
ggcctaggaa tactcattcg aaagatgggg ggactggagt gccgagtggc tgtggcagcc 360
acgattgggg tttggaaacc atcctgaaag gcccggggag ccagtctcct ggaacttctc 420
cctccccatt cccacaaaaa ccaagcgccc tctcggccaa ttctcaccct ctcaggacaa 480
aaaagtgaga tgagcccgtc ctttcacctg cgagtccaag cccttggcag aggcctgaaa 540
agtccgaaaa ctccgagttc gggcgctgag gtctcccgag ccggttcctg aactctccgg 600
gcctcagtcg atcggggtgc ggagggggcc gacccggggg atctccaagc gccctccccg 660
ccctgacgct gtggggctcc taccgcgccg ccacagctgc tcctacctgg ggaggtgcgc 720
ccgggccccg gggggcgggc agtcgggggg cgggcaggga accggtgccg ccccacgctt 780
cgtggcccct ttaaggaggg gaagccggcg gagggaggag ccggtccggt gtgtgcaggg 840
gagcgcctcg ccagcggtcc gcagggctgg agacccacgc cgtggagagg accagcctca 900
ggtcgccccg cctgggcccg cgccccgacc tcgctgcccc cgcctcgcct ctctgcccgt 960
ggcgcttacg gccaccttgg cctcgggggc agggcatggg cggcccccgc cagatcgccc 1020
agcgccagta ctaactgccc tcgctctggc cttcgagccc gaagcctctt ctgcgcgcac 1080
aacctaggca gtaatcctaa actagcgggc accacagacc agctgcagcc accccaaccc 1140
agggatcact tccggacccc tcgaccgccc ggcaccagcg cgcaagggac ccttcagccg 1200
<210>41
<211>1200
<212>DNA
<213>智人
<400>41
ctgacgacta tttccagaga tcctctcccc tgccccattc cagcccagtc actctgagag 60
cgcgagggac aggccaggcc gaggcttctt cgtacagtca cacccgtttc tgggctgact 120
ttcccaaagc ctcagagcag ctctccccac cctaccccgt ccagccccct cgccgtctcg 180
cccctcccca gccccgagct agaagttcag cctcaagacg gcagcaaacg gcagagcaaa 240
ggagtcgttt tctttcacct gaaagccgcg aggaggcttg gagcgccttt cctcgctggg 300
gcccgagctt cctgggcttt ggccgggtgc gggcagaccc caccggggtc ctcgtcatct 360
cccagcccag cccgcagagc gagtaccggc agatttcaag ggcgcgtgag cctggctgtc 420
ggctgggccc ctgaggctcg ctgggcgggg gcaggccggt ccaggctgtg cggggcgttt 480
acaaaaagtg acttggagat gaactcgccc gtgcgcggct ggccgccccg ctataggggc 540
gaaggcgcct gacgcaagcg gaactcggtg gagcccatac gaatcagaac agagcgaggc 600
tcctggcgca ctagggactc caggaggcag ctccgccaga gacgcgggtc gtgcttcggg 660
aaaccggggg gcggggggag gggaagagcg cagaaaagaa aacccaccaa ggcggggact 720
ggcctgagcg gggaggggcg gcgaggccgg agcccctctc tgttgggcgg actccccatg 780
gccagaggct gagctccact cccgccggcc gctccctagg ggaaggggaa ggagagggga 840
gagcagcgac aggcctccag caagcaagcg cgggcggcat ccgcagtctc cagaagtttg 900
agacttggcc gtaagcggac tcgtgcgccc caactctttg ccgcgccagc gcctggagcg 960
gagagcagag gcggcccggc cgcggcgcgc cggctttgtc atgatggcca gctaccccga 1020
gcccgaggac gcggcggggg ccctgctggc cccagagacc ggtcgcacag tcaaggagcc 1080
agaagggccg ccgccgagcc caggcaaggg cggtgggggt ggcggcggga cagccccgga 1140
gaagccggac ccggcgcaga agcccccgta ctcgtacgtg gcgctcatcg ccatggcgat 1200
<210>42
<211>1200
<212>DNA
<213>智人
<400>42
gaaaggagct cataggaagg ggcacagcac aaggctcccg aaagaggtca ctgcaagtgt 60
cctgcgcaat ttctgttcag cacctctgca gtgacgacag gggtttgctt tcgtaagcag 120
catcgttttc actactacag aagcacatac gccgcgtgca gcttaggccc gagcaaagtc 180
cctgctcccc tagacccagt cccttcaggt gtccccctag gggaactgtg gcgtgtcccc 240
ccaaccaggc gcactcgcct aaactgcgtc cccgaactcc agggcgcagg gagccctcgc 300
gggctgcccg gggctggggc ccacacctga acggaggagc cggctggcgg agcggccccg 360
cgcgcgcaca cacgcacact cacagacacg cgcaaaccca cagcggcgcg cgcgctcccc 420
attggcggga ggaggaaggc ggggccggcc gacccaaaac aaacaacctg cgccagcgac 480
tttgccgccg cgctgcagtg tggcctccgc ctggtgcgcg cccgttgggg agctggggaa 540
ctggggagcc gccaccacct cggccacctc gttcccccac cccttgccgt ccgcgctcag 600
gccccgcccc cgcggagccg ccgcagggtt atattgggcc ggcccgaagg tggaggcgag 660
acgcagccgc ggcaggccag cggggagatg ctgccccgga ggctgggagc gggaaggcgg 720
ctgcgggcgc agcggcctcg gggactcgcc tccgcgggtg ctcaaggctg aaggcgccgg 780
accttccccc acggtggcac gcacatcatc cggcaccatt tccgtgcccc gaagacgccc 840
gcgcgggacc tgggaccgcc agtgaagaac ccctcctggg ctctttaacg agcagcagat 900
gcgcatgctg cttctctccg gcaggaaagc cttctaagcc cggcgtgctc gggcacccga 960
gggtggaacc gcggcccctg cacacactca ccccaaagtc tcaacgtcga accgaaggcg 1020
acacccaccc aactcctccc tctccgcccc atagtccacc caacacttgc agcccctcca 1080
gagaaaaagc ccagcggaag aggactccgg aaaagtgact atctcggaag accagggtag 1140
agctcccggg agaaaaaggc gaagatcccc ggccccggat cgccatcccc ttccctggca 1200
<210>43
<211>1200
<212>DNA
<213>智人
<400>43
gctcccgaaa gaggtcactg caagtgtcct gcgcaattt ctgttcagcac ctctgcagtg 60
acgacagggg tttgctttcg taagcagcat cgttttcact actacagaag cacatacgcc 120
gcgtgcagct taggcccgag caaagtccct gctcccctag acccagtccc ttcaggtgtc 180
cccctagggg aactgtggcg tgtcccccca accaggcgca ctcgcctaaa ctgcgtcccc 240
gaactccagg gcgcagggag ccctcgcggg ctgcccgggg ctggggccca cacctgaacg 300
gaggagccgg ctggcggagc ggccccgcgc gcgcacacac gcacactcac agacacgcgc 360
aaacccacag cggcgcgcgc gctccccatt ggcgggagga ggaaggcggg gccggccgac 420
ccaaaacaaa caacctgcgc cagcgacttt gccgccgcgc tgcagtgtgg cctccgcctg 480
gtgcgcgccc gttggggagc tggggaactg gggagccgcc accacctcgg ccacctcgtt 540
cccccacccc ttgccgtccg cgctcaggcc ccgcccccgc ggagccgccg cagggttata 600
ttgggccggc ccgaaggtgg aggcgagacg cagccgcggc aggccagcgg ggagatgctg 660
ccccggaggc tgggagcggg aaggcggctg cgggcgcagc ggcctcgggg actcgcctcc 720
gcgggtgctc aaggctgaag gcgccggacc ttcccccacg gtggcacgca catcatccgg 780
caccatttcc gtgccccgaa gacgcccgcg cgggacctgg gaccgccagt gaagaacccc 840
tcctgggctc tttaacgagc agcagatgcg catgctgctt ctctccggca ggaaagcctt 900
ctaagcccgg cgtgctcggg cacccgaggg tggaaccgcg gcccctgcac acactcaccc 960
caaagtctca acgtcgaacc gaaggcgaca cccacccaac tcctccctct ccgccccata 1020
gtccacccaa cacttgcagc ccctccagag aaaaagccca gcggaagagg actccggaaa 1080
agtgactatc tcggaagacc agggtagagc tcccgggaga aaaaggcgaa gatccccggc 1140
cccggatcgc catccccttc cctggcacca gcttctctag gctgcgcgaa ggaagagggt 1200
<210>44
<211>1200
<212>DNA
<213>智人
<400>44
gggactaata gatttattcc aggtgatagt gggaagcagc tacagaagga ggattggaag 60
gctgaggggt tgttaaagtt atctgatgat attgttcgaa catttctccg gcacagaaac 120
tccacaaaga actcctctgc agttttcgct acccagggct gtttctttaa attgtttgac 180
gtcagagaag gaatgctata gcaacagtct gtcaaactgg aattaactca gaagaaaaat 240
gggggtgggg agaggaaaaa tgctcccagg cggtactgac ttcagaggaa gcaaattgga 300
tagatgcatt tattttatga cattttaaac ataaaacacc cagataaatg tgaaaaaaaa 360
aaaaactcga ttgagatgca tgtggtgttt aactcatgca gagaagagcg acttggcagg 420
gatatctgga aggccttcca gttttatcaa tgacaatagg aacaataact tccaagtatt 480
ggccatttat ttggaggcag gcttcgtgca aacatcactt catttaatat gcttagcacc 540
tttatgaggc aggtatcagt atctttattt tggcgatgac gaaacttagg cccgagacgg 600
tacacggtcc tacaactagt gatggaagag cggggactgc aacgcaaggt tgtgcaactc 660
tgggcttcag tttactttct gacatttaga attccagaat gggaaaccta aatggggcct 720
ttggggtctt ctagctctgc ccttcgatcc tgctaacaag caaactggcg cctgtcagcg 780
ccggaaagga aactggccac gccacttaga cgggcgctac ttagcagcgt gccccggcgc 840
cacaccaaca agaaaacgaa actgcccggg aatgaatgtt tttcttctcc ttctggcagg 900
aaacgagaga gaaaatagga agcagaagct gcgcgcggcg cccgctccct tcgccccccg 960
cccgggctgc gcgcgctccg agggtctgcg cgtccccggc acgtccccgc cgggcccgcg 1020
cgcctcgtgc ctcgcgcctc gcgcctccag ccacgtcccc gccccggctc cggcgcgccg 1080
cggagttggc tgctgggagg tgcgggactg ggtgtggccg gcggctctgg tctcggctgt 1140
gagctgcgct ctccacgccg gctccgcgct ccaggggctg ctgagcgccc agcggacacc 1200
<210>45
<211>1200
<212>DNA
<213>智人
<400>45
gtaaccagga atgatttgac tgtataaatt tatcttacag acacacttgt ttgtacattt 60
aatgcctgct ttctataata tgaaaaaata cacagaacgt tttatgcaat tggctctgag 120
taatgcaaca cataaatgct ttgagagcag ttaccaaaaa ttatgcaggt tattacaaaa 180
gttatatgga attgcacaga tattctaaat gtgcttttga gtaaatttct cagctaccag 240
aggcctgggc agctgtttcc agcacatcct ggcacaacat tcatgttatc atccacttat 300
gtattccaca atttcaaatg attgataaga cacctccccc atctttgctt cctcttggag 360
gaaaaaaata tacaagcaat cacgagcaca ggagcaggtg gacaactaca tcttaggaaa 420
gggtgcgtaa ctgtgaactc taaacgtgag ctgggtgcct gatgcagtat aggaaccaca 480
gtaagtcgat aatcagtgag gctggaggat tgaaatttta tttggtaaag aatattgagc 540
caggcgcggt ggctcatgcc tgtaatccca gcactttggg aagccgaggc gggcagatca 600
caaggtcagg agatcgagac cagcctggcc aacatagtga aacctgcctc tactaaaaat 660
acaaaaaatt agccgggcat ggtggcgggc acctgtaatt ccagctactc aggaggctga 720
ggcaggagaa tggcttgaac ctgggaggtg gaagttgcag tgagctgaga tcgtgccatt 780
gcactccagc ctgggagaca gtgtgagact ccatctcaaa aaaaaaaaat gaatattgaa 840
atagagtcta taggaaaaaa actccttgaa tctagtaaat gtggaatcac aaaattgaaa 900
taatgtgcat ctgaaaagtg aataaataga tgccaagaag gagtgagtca taagcacatg 960
agttgtaaga ggttgaactt gagagaccag atcaggcagt gccgcttaat accatcacat 1020
gatcctcccc gaggccctgt atttaattaa aatagagagg gaggcaccac agatgccaga 1080
agaacactgt tgctcttggt ggacgggccc agaggaattc agagttaaac cttgagtgcc 1140
tgcgtccgtg agaattcagc atggaatgtc tctactattt cctgggattt ctgctcctgg 1200
<210>46
<211>1200
<212>DNA
<213>智人
<400>46
tcctacctcc ctggccactc cttttcagac tcctttgctg gtttgctctc atttttccct 60
aacctttaca tgttgatatg ccagagcacc tcaaaccctt agacctcatc tctgctactc 120
gtgctcccat ggtgatctca tctagtctct ggtttcaaac acagagtgat cactcctgta 180
cttgctgttt cccttttcct ggagttctct ctgcctcctg caggtaggaa gtgattcgag 240
ataagagagg gagagaactc ttctggccag gatagagggt gattctgaga aggcttcaag 300
gaagaagtga gcatttgagc acggctactt gaggaaggct aggccatgga cattagggtg 360
caggcaggag cagagcaaac atgcttgtaa aaggaacagc aattattctg ttttatattt 420
atatcagccc atggtggccc ccacagcaga gtggcttgat ctctcacctc cttcaggtct 480
ttgtttaaag attaacttct ccatgaggcc ttctatgaac ataaccttta aaaacataaa 540
tccccttcct actgggactc ccccagttcc caccctgaga ccccctatct ctcttctcga 600
ttttatttct ctccatagga tgtgtatcac cacctgactt actagctatt tactatatat 660
tagtttattt cttccccatt agaatgtaaa cttcctgagg gcagggattt tgtctgttga 720
gttcagttct gtatccccag cacctaaaac agtgcctgtc cataacaggc atgttaaaca 780
ttgttggaca gatgaatgag tgaatgaaaa atggtagtac ctttcctcct ccagtccatc 840
ctacacaaag aggcaagatt aatttcccta aatgcgtgag cattaggaag tgggagggat 900
tggaggagga aattataata aggaatccat aaattactta agcccataaa acaaaggtag 960
gaaacattca agataagaga cctcttctgg ccaggataga ggttggttct gagaaggctt 1020
caaggaatag gcagacattt cagcaaggct gctgaggaag gataggctgt ggaaattagg 1080
atgcaggtag gaggatcaca gagcaaacac tccaaggtgg gaaatgcaag tgtgtgtaga 1140
aggaacagca agtattgttg ggttgggctg gcttatgaag ttgtgacggg ctgagggaga 1200
<210>47
<211>1200
<212>DNA
<213>智人
<400>47
tgtgtatcac cacctgactt actagctatt tactatatat tagtttattt cttccccatt 60
agaatgtaaa cttcctgagg gcagggattt tgtctgttga gttcagttct gtatccccag 120
cacctaaaac agtgcctgtc cataacaggc atgttaaaca ttgttggaca gatgaatgag 180
tgaatgaaaa atggtagtac ctttcctcct ccagtccatc ctacacaaag aggcaagatt 240
aatttcccta aatgcgtgag cattaggaag tgggagggat tggaggagga aattataata 300
aggaatccat aaattactta agcccataaa acaaaggtag gaaacattca agataagaga 360
cctcttctgg ccaggataga ggttggttct gagaaggctt caaggaatag gcagacattt 420
cagcaaggct gctgaggaag gataggctgt ggaaattagg atgcaggtag gaggatcaca 480
gagcaaacac tccaaggtgg gaaatgcaag tgtgtgtaga aggaacagca agtattgttg 540
ggttgggctg gcttatgaag ttgtgacggg ctgagggaga gacaggactg gaaaagcacg 600
ttggggtcag gttgcagagg tccttgactg acagagaggg gagcttggtc tgtggggaat 660
cttctgctct gtgtggtcag aggctggtct gactctccgg ccttgcccca gtcttcctat 720
ccttcatcca gccccggctg gctcggtaaa aacggcgcga atctcgctct ccctgggtaa 780
ctagggtccc cactgcctgg ctagtggtgc ttttcgcgtc ttcactggca ccattaatga 840
atgaagtctg gctcccaccc gcggggaagg gaggagcctc aacctcgggt cctttgctct 900
cctgcagcac tcctgcccgg gtcccgcctc ggggtcgcca ggccctgaac cccaacgccg 960
gcattagtcg cgcctgcgca cggccctgtg gagccgcgga ggcaagggac ggagaacggg 1020
gcggaggcgg agtcagggcg cccgcgcgtg ggccccgccc ccttatgtcg ggtataaagc 1080
ccctcccgct cacagtttcc ctagtcctcg aaggctcgga agcccgtcac catgtcgtgc 1140
gagtcgtcta tggttctcgg gtactgggat attcgtgggg tgagtgccgt ctcaacggta 1200
<210>48
<211>1200
<212>DNA
<213>智人
<400>48
actgacactt tcattcatat gtttagaaga gacatatctg aagaaaattc tttttaaaat 60
agtttctcag ctgagattat acttttttag tgtgtagctc acaggaagtt ctagttgcca 120
agagcatgtt cgatatgagt agatctctac ctaattctta tgcataatga acccaatttt 180
catctcttct agaaagatac tgaaaacatg tgtcgtgatc tcaatgttac aaccatgtag 240
cctcatcttt cacaatacgg tacaatcacc aacgaagttt aaacttcatg tctggcatcc 300
aaggtgaaca tttccataga aagtaggaaa tatttagatg tctgtttgcc gtggtggtgg 360
tgttcctata tactttttgt gaccctaaag atataataat gtttgacatt tttgttagcc 420
agtaatgtgg acttaagaca tcctaaccac actgctgact ctaacccttt aatagacttt 480
cacgtagttc ttgagcctca ctgcaggctc cagtgctagt cccggaggaa atcagaaaag 540
ggttgaaacc actgacacag ccatctcttt agctcctcct aacgcaggtg tacagtttcc 600
tgtagtgagc agatcggggc ctacagggac actgcatgct tgcactgggc tgttactagt 660
ttcatggaaa tatgtactaa ttgtgtcact gtgttttctt gtcacactgc cccctttcta 720
ggccgctctg gcaccgttta tttaaactgt gcaaccatct ggcccaggtg ccgtagagat 780
tgatcagtag cacaaggcca ccacaagcac aaccgccacc cggccatccc agctatttcc 840
tccagcattc tagacatcat ggcgtccgag ggtgggtcca acgggcttcg agtgttcggg 900
agataatgca cacttcgcag tggatcttct cggggccccg agcgttgccc gcccattagg 960
tggcgccggt cccctcgaac aggtcgctca acaactcccg cccagcagcc gcccttactg 1020
cgcgcgcgca gacttcggcg tctacttccg gtgtggccca ggcggggtcc gcagaaccag 1080
ctatgtcggc ctacggcatg cccatgtaca agagcgggga cctggtgttt gccaagttaa 1140
agggctatgc ccactggccg gcgaggatag agcacatgac ccagcccaac cgctaccagg 1200
<210>49
<211>1200
<212>DNA
<213>智人
<400>49
tttttagtgt gtagctcaca ggaagttcta gttgccaaga gcatgttcga tatgagtaga 60
tctctaccta attcttatgc ataatgaacc caattttcat ctcttctaga aagatactga 120
aaacatgtgt cgtgatctca atgttacaac catgtagcct catctttcac aatacggtac 180
aatcaccaac gaagtttaaa cttcatgtct ggcatccaag gtgaacattt ccatagaaag 240
taggaaatat ttagatgtct gtttgccgtg gtggtggtgt tcctatatac tttttgtgac 300
cctaaagata taataatgtt tgacattttt gttagccagt aatgtggact taagacatcc 360
taaccacact gctgactcta accctttaat agactttcac gtagttcttg agcctcactg 420
caggctccag tgctagtccc ggaggaaatc agaaaagggt tgaaaccact gacacagcca 480
tctctttagc tcctcctaac gcaggtgtac agtttcctgt agtgagcaga tcggggccta 540
cagggacact gcatgcttgc actgggctgt tactagtttc atggaaatat gtactaattg 600
tgtcactgtg ttttcttgtc acactgcccc ctttctaggc cgctctggca ccgtttattt 660
aaactgtgca accatctggc ccaggtgccg tagagattga tcagtagcac aaggccacca 720
caagcacaac cgccacccgg ccatcccagc tatttcctcc agcattctag acatcatggc 780
gtccgagggt gggtccaacg ggcttcgagt gttcgggaga taatgcacac ttcgcagtgg 840
atcttctcgg ggccccgagc gttgcccgcc cattaggtgg cgccggtccc ctcgaacagg 900
tcgctcaaca actcccgccc agcagccgcc cttactgcgc gcgcgcagac ttcggcgtct 960
acttccggtg tggcccaggc ggggtccgca gaaccagcta tgtcggccta cggcatgccc 1020
atgtacaaga gcggggacct ggtgtttgcc aagttaaagg gctatgccca ctggccggcg 1080
aggatagagc acatgaccca gcccaaccgc taccaggtgt ttttcttcgg gacccacgag 1140
acggccttcc tgagtcccaa acgcctgttc ccgtacaagg agtgcaagga gaagttcggc 1200
<210>50
<211>1200
<212>DNA
<213>智人
<400>50
aaaggcaaat tatgtgcaca tgaccctgtc actacaaggt agttctcgac caagctacat 60
cttatagctt tatcttatat tcctctccca tcatctgcag gaaaagggat aggtgctgag 120
ggaaaacccc taagtagaac tcacagtaag cagtgggaaa acagcttatt tcactaacgg 180
ggttaagtgg ccctgaaaag agcctttgga gacaaagcag ccggcgaccc gcggagggag 240
ggagggaggg agcgagcgag cgccaggtcc cggcagggac tcacttggag ctggcgtact 300
tggtgaccgc cttggtgccc tcggacacgg cgtgcttggc cagctcgccg ggcagcagca 360
ggcgcacggc cgtctggatc tccgggacgt gatggtggag cgcttgttgt agtgcgccag 420
gcgggacgcc tctcccgcga tgcgctcgaa gatgtcgttg aggaaggagt tcatgatgcc 480
catggccttg caccagatgc cggtgtcggg gtggacccgc ttcagcacct tgtacacgta 540
gatggagtag ctctccttgc ggctgcgctt gcgcttcttg ccgtctttct tctgggcttt 600
ggtgacggct ttcttggagc ccttcttggg agccggcgcg aactttgcag gctcaggcat 660
ggccagaccc aagaccgaca ccgacccccg agaacgcaag cagagcggta ggctcggggt 720
ctaccggaaa cgactgtgta cttacagagg ctgtgcgcat gacgctgcgt tatggttcgc 780
gagttttccg cggcgcgcaa tgcgagggag acgagattat gtaaatgagt ggattctggc 840
tgagctatcc tattggctat cgggacaaaa tttgcttgag ccaatcaaag tgctccgtgg 900
acaatcgccg ttctgtctat aaaaaggtga agcagcggcg ttttcggcga ctttcccgat 960
cgccaggcag gagtttctct cggtgactac tatcgctgtc atgtctggtc gtggcaagca 1020
aggaggcaag gcccgcgcca aggccaagtc gcgctcgtcc cgcgctggcc ttcagttccc 1080
ggtagggcga gtgcatcgct tgctgcgcaa aggcaactac gcggagcgag tgggggccgg 1140
cgcgcccgtc tacatggctg cggtcctcga gtatctgacc gccgagatcc tggagctggc 1200
<210>51
<211>1200
<212>DNA
<213>智人
<400>51
ctatataaac caaaaattgc ttcaaccaca gaatggaggt ctacaggtgc ggaaggaaag 60
tttatatggt gaggcttggt cgcaaaacta ttaggaatat tttcaggtta ctacacaatt 120
ttgcgagctc aatatgcagt taacactttt tccctcgact ctcctgagca gatttacatt 180
gaccgcaccc gtagcatatc gtctcacttt ggaaaaggca aattatgtgc acatgaccct 240
gtcactacaa ggtagttctc gaccaagcta catcttatag ctttatctta tattcctctc 300
ccatcatctg caggaaaagg gataggtgct gagggaaaac ccctaagtag aactcacagt 360
aagcagtggg aaaacagctt atttcactaa cggggttaag tggccctgaa aagagccttt 420
ggagacaaag cagccggcga cccgcggagg gagggaggga gggagcgagc gagcgccagg 480
tcccggcagg gactcacttg gagctggcgt acttggtgac cgccttggtg ccctcggaca 540
cggcgtgctt ggccagctcg ccgggcagca gcaggcgcac ggccgtctgg atctccggga 600
cgtgatggtg gagcgcttgt tgtagtgcgc caggcgggac gcctctcccg cgatgcgctc 660
gaagatgtcg ttgaggaagg agttcatgat gcccatggcc ttgcaccaga tgccggtgtc 720
ggggtggacc cgcttcagca ccttgtacac gtagatggag tagctctcct tgcggctgcg 780
cttgcgcttc ttgccgtctt tcttctgggc tttggtgacg gctttcttgg agcccttctt 840
gggagccggc gcgaactttg caggctcagg catggccaga cccaagaccg acaccgaccc 900
ccgagaacgc aagcagagcg gtaggctcgg ggtctaccgg aaacgactgt gtacttacag 960
aggctgtgcg catgacgctg cgttatggtt cgcgagtttt ccgcggcgcg caatgcgagg 1020
gagacgagat tatgtaaatg agtggattct ggctgagcta tcctattggc tatcgggaca 1080
aaatttgctt gagccaatca aagtgctccg tggacaatcg ccgttctgtc tataaaaagg 1140
tgaagcagcg gcgttttcgg cgactttccc gatcgccagg caggagtttc tctcggtgac 1200
<210>52
<211>1200
<212>DNA
<213>智人
<400>52
gatggagcag aagctctaat tgcttcgagg tacaagtcca tctaaacctc tgagatctca 60
cccgtccccg gtaagccctt gcgccctcca gacaagctcc tcagtgaaag caagcgccgc 120
accggtgcct gtgccagtct cccagaaagg agcataagga gtgttccacc accactctgg 180
attctttatt ccaacaaccc agccggaggg gaaaatctgc taaaccaccc cacaaggcag 240
aaactttatc aaaatctggc actacaacac tggccctcat cacgccgcca caaattgcga 300
gggatagaag aaagctgcaa agtcacgtta aaaggaagcc tagtcaaaaa gtgaaaattt 360
tgtcccgccc taggcacaca gcactcacag cataagatgt agttccatga gtcctaggaa 420
agggggaaga aaggaaaaaa ccaaacatct gctctaggtt tagaagaggg ataacatcag 480
cgccaagcaa accgaaagcg cagaggactc agaagagggg aagaggaata actttatctg 540
tcctggaggt gggcgaagag cagtctccac cggccgcgcg tcacgctccc atttaacctt 600
ttccatgccg cgacgcccac actccgccct cgagggacta gcccccccca cgatccagag 660
cagaagcggc tcgccccgct gcatccacgg gccctcaccc aagcgtccag tcctgccttt 720
ctccccccac ctcgcccaat acctgtccga gagcaggcgt tctgccctct cgccccgccc 780
ttgcccaggc agcccccggt cgcgacggct ctcctcgggg ctcgggggcg ctgggcggcg 840
gccctgggct gctttggcta acttggctgc ggggcaggcg cgaggagcgg cgcgccgacc 900
gggccgagcg gagaggccgc ccattggccg gccagcgcca cgtggccgcc cccgccggta 960
tattaggcca ctatttacct ccggctcact cgccatgggt tggagagggc agctcgggta 1020
gagagggctg gcggagcggc gcagacggcg gcagtcctgc tcagcctctg cccggctccg 1080
tactccggcc ccggcctgcg ccctcagaaa ggtggggccc gaaccatgag ctcctacctg 1140
gagtacgtgt catgcagcag cagcggcggg gtcggcggcg acgtgctcag cttggcaccc 1200
<210>53
<211>1200
<212>DNA
<213>智人
<400>53
gcctgtgcca gtctcccaga aaggagcata aggagtgttc caccaccact ctggattctt 60
tattccaaca acccagccgg aggggaaaat ctgctaaacc accccacaag gcagaaactt 120
tatcaaaatc tggcactaca acactggccc tcatcacgcc gccacaaatt gcgagggata 180
gaagaaagct gcaaagtcac gttaaaagga agcctagtca aaaagtgaaa attttgtccc 240
gccctaggca cacagcactc acagcataag atgtagttcc atgagtccta ggaaaggggg 300
aagaaaggaa aaaaccaaac atctgctcta ggtttagaag agggataaca tcagcgccaa 360
gcaaaccgaa agcgcagagg actcagaaga ggggaagagg aataacttta tctgtcctgg 420
aggtgggcga agagcagtct ccaccggccg cgcgtcacgc tcccatttaa ccttttccat 480
gccgcgacgc ccacactccg ccctcgaggg actagccccc cccacgatcc agagcagaag 540
cggctcgccc cgctgcatcc acgggccctc acccaagcgt ccagtcctgc ctttctcccc 600
ccacctcgcc caatacctgt ccgagagcag gcgttctgcc ctctcgcccc gcccttgccc 660
aggcagcccc cggtcgcgac ggctctcctc ggggctcggg ggcgctgggc ggcggccctg 720
ggctgctttg gctaacttgg ctgcggggca ggcgcgagga gcggcgcgcc gaccgggccg 780
agcggagagg ccgcccattg gccggccagc gccacgtggc cgcccccgcc ggtatattag 840
gccactattt acctccggct cactcgccat gggttggaga gggcagctcg ggtagagagg 900
gctggcggag cggcgcagac ggcggcagtc ctgctcagcc tctgcccggc tccgtactcc 960
ggccccggcc tgcgccctca gaaaggtggg gcccgaacca tgagctccta cctggagtac 1020
gtgtcatgca gcagcagcgg cggggtcggc ggcgacgtgc tcagcttggc acccaagttc 1080
tgccgctccg acgcccggcc cgtggctctg cagcccgcct tccctctggg caacggcgac 1140
ggcgccttcg tcagctgtct gcccctggcc gccgcccgac cctcgccttc gcccccggcc 1200
<210>54
<211>1200
<212>DNA
<213>智人
<400>54
aacagtgtga aaagtcacat gataaactgg ggaagatatt tacagtacat gtaatggaca 60
gagggttaat gttcttgcta gatatcttaa aatcaagaaa aataaactca gtaaaaagat 120
gcaaagggca taagatggaa ttcacacaca gtgcaagttg aatttttttt tttttttttt 180
gcctgccaga gtgctacagg taaaacagat tgctactacc cagtgttgct ggtgggctag 240
agtgttcatg tagctttctg caggccagtc tgagaatatt tattaggatt ttaaaagtgc 300
attcattgac cagcacttca cttctgaatt taatgcaagg aaatagttgg gtaaatgggc 360
aaaactattt tgtacaaaaa tattcattgt gttcataata gcaaaaaatt ggaaatcatc 420
caaatgtcat ttgtgttata actccataca ctggaaaagt gagcagccat gaagatggtg 480
tagatttgtt tcaccagcat ggaaaggtgc ctgttacata tttaagtgtg aagatgaggt 540
tgtaaaatgt atgcctggta tgctatgatt tcataagaca cgtggaacta tatcttctta 600
tatgccgatt gatgaagatg gaatcagtgt atataccaaa gagattaaaa gtggttcttt 660
atctgagtga tgattttgtc ttcattgtgt ttagaatact aagaagtttc agcagtggaa 720
tgcctactct tcttataacc ggagtggaaa cggaagcatt ttgtgagagg gctggaggga 780
aggtgagaac gggcgttggg aggcccttcc gtggctccag gcctagggct gcggaaccca 840
caacagaacc cgcaaccgca accgggaacc cgagtgcctg cctagctggg gggccggagg 900
gagggcgggg agggcagcgc cacggacccc agcggaccgg aagggcttgt ggcacgcgga 960
atccccctca gaggccccca gctgccttcc ctgtggcatc atgaagtttc gcgccaagat 1020
caccggcaaa ggctgtctag agctgttcat tcacgtcagc ggcaccgtcg cgaggctagc 1080
gaaggtctgc gtgctccgcg tgcgccctga cagcctgtgc ttcggccccg cgggttccgg 1140
cggcctccac gaggccaggc tgtggtgcga ggtgcggcag ggggccttcc agcagtttcg 1200
<210>55
<211>1200
<212>DNA
<213>智人
<400>55
ggccaagcaa acacccgctc atatttagtg catgagcctg ggttcgagtt gccggagcct 60
cgcgcgtagg gcaggggttc gagcgcccct tctccctgcc tcgcctctgc gcctgggggc 120
tgctgcctca gtttcccagc gacaggcagg gatttcgagc gtccccctcc cctccctcgt 180
caagatccaa gctagctgcc tcagtttccc cgcggagcct gggacgccag cggaggggct 240
cggcgcgtag ggatcacgca gcttccttcc tttttctggg agctgtaaag acgcctccgc 300
ggccaaggcc gaaaggggaa gcgaggaggc cgccggggtg agtgccctcg ggtgtagaga 360
gaggacgccg atttccccgg acgtggtgag accgcgcttc gtcactccca cggttagcgg 420
tcgccgggag gtgcctggct ctgctctggc cgcttctcga gaaatgcccg tgtcagctag 480
gtgtggacgt gacctagggg gaggggcatc cctcagtgga gggagcccgg ggaggattcc 540
tgggccccca cccaggcagg gggctcatcc actcgattaa agaggcctgc gtaagctgga 600
gagggaggac ttgagttcgg accccctcgc agcctggagt ctcagtttac cgctttgtga 660
aatggacaca ataacagtct ccactctccg gggaagttgg cagtatttaa aagtacttaa 720
taaaccgctt agcgcggtgt agaccgtgat tcaagcttag cctggccggg aaacgggagg 780
cgtggaggcc gggagcagcc cccggggtca tcgccctgcc accgccgccc gattgcttta 840
gcttggaaat tccggagctg aagcggccag cgagggagga tgaccctctc ggcccgggca 900
ccctgtcagt ccggaaataa ctgcagcatt tgttccggag gggaaggcgc gaggtttccg 960
ggaaagcagc accgcccctt ggcccccagg tggctagcgc tataaaggat cacgcgcccc 1020
agtcgacgct gagctcctct gctactcaga gttgcaacct cagcctcgct atggctccca 1080
gcagcccccg gcccgcgctg cccgcactcc tggtcctgct cggggctctg ttcccaggtg 1140
agtcggggtg gggattgccg tcgggccagt tctccgaagc cccgggagga ccggctcccg 1200
<210>56
<211>1200
<212>DNA
<213>智人
<400>56
gggagggtcc cacggacata ttgagggacg tggatacgca gaagaggtat ccatgtggtg 60
gcagccggga aggggtgatc agatggtcca cagggaatat cacaaactcg aattctgacg 120
atgttctggt agtcacccag ccagatgagc gcatggagtt gggggtgggg ggtgtcaaag 180
cttggggccc ggaagcggag tcaaaagcat caccctcggt cccttgttct cgcgtggatg 240
tcagggcccc cacccaccga gcagaaggcg gactcagggg cgctccaggg tggctcgagc 300
tcacacacgc tgagtagaca cgtgcccgct gcaccctggg taaatacaga cccggagccg 360
agcggattct aatttagacg cccgcgaacg ctgcgcgcac gcacacgtgt cctcggctcg 420
ctggcacttt cgtcccgccc cctccgtcgc gtgcgggagc tgacccggag gggtgcttag 480
aggtatggct ccgcggggtc aaaaggagaa ggatcagtga gagaggcatc cccacaccct 540
cccctagaac tgtcctttcc ccatccagtg cctcccaaat ctctcttagt ccccaaatgt 600
atccccgccc taaggggcgc tggtgggagg agctaaatgt gggggcgggg ctcggagtcc 660
agcttattat catggcatct cagccagggc tggggtaggg gtttgggaag ggcaacccag 720
catcccccga tcccagagtc gcggccgggg atgacgcgag agagcgtggt cgcccccaga 780
aggccctggg ccatcatgcc ggcctccacg tagaccccag gggtcgctca ctcctgccag 840
ctcgccttca ccaaggccag gagcttagcg cacgctcgcc tcccgccccc ccgccgcctc 900
tgccgccgcc ccctccttgg aaaccaagtt accaacgtta aaccaatccc caagcgcaac 960
tctgcctccc ccacacccca cccgccgcgc cgcgcggagc cgtcctctag cccagctcct 1020
cggctcgcgc tctcctcgcc tcctgtgctt tccccgccgc ggcgatgcca gggccttcgc 1080
cagggctgcg ccgggcgcta ctcggcctct gggctgctct gggcctgggg ctcttcggcc 1140
tctcaggtaa gagccccgct ctggttcggg gtggacaggg cgggggcgga gtccctggac 1200
<210>57
<211>1200
<212>DNA
<213>智人
<400>57
ggaaagggga tcggggagga aagtcgggga ggcgaggtgg gggcggtggg ctgagcggga 60
acttaaaaga ccgcggtgga gaagatgggg cgttctccgc gacactcggc tgcccagagg 120
tgcaaagccg gtgggcgcac gcccggggcg gccctacagc cctcgggccg ccagtctcag 180
ggtgtcgggc tccaactaag gccccgaagc ccccacgcac ctgagggcat tttgaccagc 240
tcttgcgggc tgtcttgcgg ccgcagtggg ttctgaaagt ccattccggc gtagggtgga 300
aaccggcggg aggcgttgct gattctcgat taaacaatag tgacgagacg cgtgcggggc 360
gcctgcgagc cccttcctgc cactcggagc agagcgcgcc agcgcgaggc cgggccggcc 420
gcctgcgcag cgccgggcta attttaactg ttgattacat cttcagcgtg tcctttcata 480
ggtctcattt gtaattgaga cgaatgatta cagtggggcg ggaaggagca gctgctcatt 540
aattaatttc taattaaaag tgcctctcgt tctcgggtga ctaaagagaa acaccgttcg 600
ctgggcgata ttgactcgga tggaatttat ttgctaacgc ccggaggaat ggcccctccg 660
tccaccgcgc ggccgggact gtcctggccc ctcccggcct gagccgccgg cgagtgaccg 720
gcgagtctgc ggccaggccg ggctgcgcga ggtggggctg acgtcagagc ctcctccgct 780
tcaagccgcg cacatctgac ttgacgggtt cgcgcgactc gttttttttt ttttcttttt 840
cgtaaaatat gtatttctgt cgccgctgcg aggccgctcg gtcccagagc cccctcgagc 900
ctccggaatg cgaagttaaa ggaatcgcgg cggccaccgc tgctcacttt gttacccggt 960
tagaaaagtt tgcggagcgc ggggatggac taaccggctc tcctgcttcg ccctcccagc 1020
gcctagaagc ctgcagctcc ggagcagtgg ccgcgccacg ccggccccag cgcgcagaac 1080
cctgcaggcc ccgcccgtcc gccccgggcc gcgcccgcca tgtcctaccc gcagtttgga 1140
tacccctact cctcggctcc ccaggtaagc ggagccccgc cccgcccagg ccaccgcagg 1200
<210>58
<211>1200
<212>DNA
<213>智人
<400>58
gaatcatagt aggtaattga gttatttttt aatttttatt ctgtctttat aagatttttg 60
agaaggtaat caattaacat aaagatctga gcagttataa agatttacaa agaagattat 120
acagtgatgg aaactgaagc atattcttgg caacaatctc aatctatttc acgtttcccg 180
gcttttacat atataaattt ggtatacata atatgtaaat atacttctat tttgcatgaa 240
aactaaaaat actaaaaaag tagcatgagt atatgaaaaa gttaaacatt aaaaatatta 300
gttggaaact ggcttatttt actaacaatt atattcagaa ttctgttgct agactgctgt 360
ttctgggaac attggaggtg tactttctat acttgctaaa atacaagctt ttcaagtatt 420
ttccatagta ttaagtgaga ctttaaatac tcttgctttt ttagatctaa tttctgcttt 480
aatttatcct tctcttcatt tttcctgttt gtcctcatct tacctgttct tccctggttt 540
tactatctcc cagtattcag aaatcagagc aaataattag tctgcttttc tgcagaataa 600
actattgggt atgccatcat gcttttgatc taccacataa acaaattatt ttagcaagac 660
atcactttta tatgctgtat aatgtatgta ttgcttatgt tttaagcaga tttcagctct 720
tttccttcca tcaatttgga attgggggcc caaaagatgt gaaggcgata atgcttccaa 780
gataactggg ctgcatcctt atttgtaaaa taagaaatac tttatttccc aaattttaaa 840
ggagtgttcc ttctccgacc tgttgtgatg gatttattct atagctatgg aaatataccc 900
tgcttcactc ttgtacatac ttctttactc tcctcccgcc aagttcattg aaagagaacc 960
catgtgccgg tccagagcat cgctgcatcc gtaagcagct agacctcagc ttcctctgtc 1020
accatggtgc cggctcggct gggcccggcg gtcgccatgg taactggggc gggtcgcagg 1080
gtcctggcag gctgggcgca tgcgcgcggg gactacaagc cgcgccgcgc tgccgctggc 1140
ccctcagcaa ccctcgacat ggcgctgagg cggccaccgc gactccggct ctgcgctcgg 1200
<210>59
<211>1200
<212>DNA
<213>智人
<400>59
taggggagag ggactcgcca aatccctgtt ttctggggta agcccccctc cccccactct 60
tggacccaag ctgcccggaa ggaagaagga agcattgttt gtcaccggag aaaaccacct 120
gtggtttgca aagggcctca gtcgagtcag gggcaggcgg ggcagatccg agcccggcgg 180
gaggggcgag gcgcgggggc gggcaggggc gagggtaggg gcgctcagct ggcaggtcct 240
gctctgcagg cctcaccgcc cagctcccgg gagggggccg agggcgccct gagtgctgcg 300
cgccttccca tgacgcagtt cctgtgcctt taaatcccac tcccggaggg ggcgggggcg 360
ccccggctgg accccggttt ccagtccggc gggggccccg gggaagccca gggcggggag 420
cgcggggctg ggggcgcgga gggcggggcg cccggggtcc ccgcccgcgc gccgcgccct 480
agcctgctgg gccgcgcccc tcttgggacc gccgcgctcc gggggcgggg gcgggggcgg 540
gggcgggggg cggggggcgg ggggcgggcg ggggcgcgcg ggcgggcggg gtgcgggcgc 600
gcgccgcgcg gcccgagcgc gcgagccggg cccggagcgc acgccgccgc cgccaccgcc 660
gccgccgccg cccgagccgc cgcattgctg ctgctgctgc cgccgccgcc ccgcgcccgg 720
cccgcggccc ccaatatggt gcagccgcca gcgccgccgc ccgtgccgcc gccgccgccc 780
gcgggccccg ccgccgccct cgggcgcccg cagcgcggca gccgcaggtg gggggccgcg 840
gcccgggcct gagctgcccc ccgcccggcc tcggcgcggc gccctccccg cggggctgcc 900
ggcgaggggc cctctcgccg ctgaggtgga gccgcgggcc ccgccgccgc cgctcctgcc 960
ccctccctcc ctcctcccct ccccctcccc tccggtcctg tctccagcgg gagcgcgaga 1020
cgctggtcag gctccgcggc gcagctcgaa aaggaataat cgcccccgat tgactgaaat 1080
tcctccggag ccggcgccgc ggccgcccgc gcccgagacc gcgctccggg gccgcgtcct 1140
cctctcctcc ggaaaacgct cgcgacccag ggccgccggc ggccgcgact ctgctgtgtc 1200
<210>60
<211>1200
<212>DNA
<213>智人
<400>60
ctttctcttt catcttcctc cctctgccag agccagggag ggagagtggg aggcgtcaag 60
gaggtagggg agagactggc agaggaaaag gagtgggtgg gtgggggcca agtaaataga 120
tacttagatg atgaagtcaa gccactgcgg caatgtttct tgtcagtttc acgcgggcaa 180
agcgtgcctt tcggtgggtt ataagcagcg cccggtccttcctt ctctcg ccaagttgcc 240
tgatccttcc ctccaggcgc gcgcgcacac accacactca cacaccccaa aaccaagact 300
cgtcctacag gatctgggaa aagaaaaaga aaaaaaagcc ctcaatcacc acctccttct 360
cgccgactcc ccctcacccc ccgcctcccc tccagcgggc agccaaggag agctagaggc 420
gggggagggg agagggagga gaagcgacgc aagtgggtag cttttcagcg ccggcgaggc 480
gcgggaggag gagaagcagt ggggaggcgc agccgctcac ctgcggggca gggcgcggag 540
gagggacccg ggctgcgcgc tctcgggccg aggaaccagg acgcgcccgg agcctcgcac 600
gcggccaagc tcggggcgtc ccctcccctc ggccgggcga actcaagggg cgcagctctt 660
tgctttgaca gagctggccg gcggaggcgt gcagagcggc gagccggcga gccaggctga 720
gaaactcgag ccgggaacaa agaggggtcg gactgagtgt gtgtgtcggc tcgagctccg 780
ggcagaggca tttgggcccg aggcccccgc tgtgactccc cgagactccg cagtgccctc 840
cactgcggag tccccgcgct tgccggcaaa aactttattc ttggcaaact tctctttctc 900
ttcccctcct cctcggcccc catcttctgc tcctcctcct tctctagcag attaaatgag 960
cctcgagaag aaaaaccgaa gcgaaaggga agaaaataag aagatctaaa acggacatct 1020
ccagcgtggg tggctccttt ttctttttct ttttttccca cccttcagga agtggacgtt 1080
tcgttatctt ctgatccttg caccttcttt tggggcaaac ggggcccttc tgcccagatc 1140
ccctctcttt tctcggaaaa caaactacta agtcggcatc cggggtaact acagtggaga 1200
<210>61
<211>1200
<212>DNA
<213>智人
<400>61
aatgagaccc agagggtcgg tcctaggaca caattcctct caccctctgc ttctgccacc 60
atcctttccc ctttgccctt ggaggtgctg gaggaggtgg gagtgtcccc gagagtgtcc 120
agactgcata aggtggcaga aaggtgctga gtgtcttcca ttgcaccagt gtcagggact 180
tggatgtggt ccccaggccc aaagccaagg cagatggact catggagggg gaggagcaga 240
ggagcagtgc ggagtcactc tctccatgta gcacccccag ctcagtgcat tgctggggtt 300
cttgcagggc agatgaagtg cttctttgta taggggaata tgtgggtgaa ccaggaaaat 360
gggagcctag tacatggagg tttattccaa ctccctgtgt gattggcaag ttagaattgc 420
ccccctacct gagttattat tggctcctga gaaacaggcc aaaggcagcc cccactaaga 480
agcttttagc acctcctata ggaaggaagc cttcccagtg aatccagtgt gaggattctt 540
ttctccaggt ctctggacct ctcccaacat gctccatgtt cctttgcacg aagaagaaca 600
gcgcagttcg gtagagtgta tgtaagcccc ggttgccatc agcacactgt gtggattctg 660
gcaatacctg tcatccccac tggtgctgcg gtgcccctca tgccccttgt taataaccaa 720
tgatagtgcc acttgaactc ccaggctgtt gtgaggagca agcattcatt cattcattca 780
ttcaatcact catttgttca tgtgacaaat gtggattgaa tgcttgccct ctttcctctc 840
ccctggagcc ttggagagag agataagaca agcgcaaata actgtgacct gttgtaggaa 900
gtgagaaata cacccaggca gggccagata ctgcgtagca ggcggggcac agaggaggga 960
acgcttgtgt ctaactgatg ctcctaatgc ggaagcccct gaaaggcggt tgtggtgcaa 1020
aggaaaaccc acaggccaag gaatgggaag accaaggttg acacttgttt gtcaagtgtc 1080
aataatcatc tctgcccggt gagttgttgc atgaagcaag atcctccttg gggggtgttt 1140
agcacagagg gggtgcgatt ttatttcctg tgaaaatacc aggtagtatt atgttcacta 1200
<210>62
<211>1200
<212>DNA
<213>智人
<400>62
catttcacct atttgactct gcctgcctag agcttgccga gaatgagacc cagagggtcg 60
gtcctaggac acaattcctc tcaccctctg cttctgccac catcctttcc cctttgccct 120
tggaggtgct ggaggaggtg ggagtgtccc cgagagtgtc cagactgcat aaggtggcag 180
aaaggtgctg agtgtcttcc attgcaccag tgtcagggac ttggatgtgg tccccaggcc 240
caaagccaag gcagatggac tcatggaggg ggaggagcag aggagcagtg cggagtcact 300
ctctccatgt agcaccccca gctcagtgca ttgctggggt tcttgcaggg cagatgaagt 360
gcttctttgt ataggggaat atgtgggtga accaggaaaa tgggagccta gtacatggag 420
gtttattcca actccctgtg tgattggcaa gttagaattg cccccctacc tgagttatta 480
ttggctcctg agaaacaggc caaaggcagc ccccactaag aagcttttag cacctcctat 540
aggaaggaag ccttcccagt gaatccagtg tgaggattct tttctccagg tctctggacc 600
tctcccaaca tgctccatgt tcctttgcac gaagaagaac agcgcagttc ggtagagtgt 660
atgtaagccc cggttgccat cagcacactg tgtggattct ggcaatacct gtcatcccca 720
ctggtgctgc ggtgcccctc atgccccttg ttaataacca atgatagtgc cacttgaact 780
cccaggctgt tgtgaggagc aagcattcat tcattcattc attcaatcac tcatttgttc 840
atgtgacaaa tgtggattga atgcttgccc tctttcctct cccctggagc cttggagaga 900
gagataagac aagcgcaaat aactgtgacc tgttgtagga agtgagaaat acacccaggc 960
agggccagat actgcgtagc aggcggggca cagaggaggg aacgcttgtg tctaactgat 1020
gctcctaatg cggaagcccc tgaaaggcgg ttgtggtgca aaggaaaacc cacaggccaa 1080
ggaatgggaa gaccaaggtt gacacttgtt tgtcaagtgt caataatcat ctctgcccgg 1140
tgagttgttg catgaagcaa gatcctcctt ggggggtgtt tagcacagag ggggtgcgat 1200
<210>63
<211>1200
<212>DNA
<213>智人
<400>63
ccaccatgcc ctttgctctc cagggctctg gggccggccc aggtcagcca cttggtggga 60
ttccagcctc agggtggctg agctgcaggt gcagcacccg gcctccaggt ggcaccaatc 120
cgcttacttt gaggtgggct ctgacaacca gctgagctgc ccacagtccc tcagactccc 180
gaggtcctgg gagcagggat caaggtggtc cccaggccgt aaacctgaca gaggctgcag 240
gagtgcattt ccacccaggg tgcactcagc gggtgtaact ccacacccgt ttctttggag 300
tcaaggcccg gcctctcagt gaggagactg ctcctggttg cccaccgtcg ggtcatccca 360
gcctgcagtg gaaccctccg cagcctggcc tcttccaggg tagcccctca ctcccctctc 420
tcctgtccta gcagacaggc cagggagggt ggacgagttc cagctctggg gatgtcccat 480
cagctgtgtc accttgaaca aatcattttg cctcttgggt ctcagtttcc tgcagtgtga 540
aacgtggtgg aggcatgagg ggcaatggga gccccaaggc ctctttcaga gacctcctct 600
gggtcccatg tgacctcgtg gctgtcccca aaggcaagag ggtccccagc cctgcggcca 660
aggccctggg acaccctatc caaacaaatg caggtctctg acgggctgag ctttgctcgc 720
ttgggtttct ttgctttctt cctttttttt ttttctttcc tggatgaaat tcctgccagc 780
tccgaaggaa ggagggaaga ggagcgagcc gcagtgtaga aagtttcctt gactcctcct 840
ccggctgggt ctccctccct tgccaagccc agcctgtgaa actgaataac gaagatcact 900
caacaatgcc tgcccctctc tgactgcacc gtcccggcgc tcccaccgcc gccgccgccg 960
cccaatagag cccctggggc ggtccccacc gacggtgcag cccgccggga ccgggaggaa 1020
gcagctgcgg ccatcgcgcc gtgcgtccgc gcccggccgc caggtgcccc agtagcccga 1080
ccgccgagat gcccagcccg ccggggctcc gggcgctatg gctttgcgcc gcgctgtgcg 1140
cttcccggag ggccggcggc gccccccagc ccggcccggg gcccaccgcc tgcccggccc 1200
<210>64
<211>1200
<212>DNA
<213>智人
<400>64
gctgaagtca cctttccagc agtgtctggt ccagccaggg catcatgccc agtaacagcc 60
ccgatgtcca acacttcccc atgtcctctt ctccccctag acactgccac cttaggggtc 120
ctggctgtta cttcgtccca gggcctgact ggtagtctta gttacacaca caacacaggg 180
gagggaggaa ggagcttggg gcaaagggag ggagtccagc cctttgcctt tccttggaga 240
aggcaaggga gacaggaatg cctttggctg ggagaccctg gccagagatc agaagatcaa 300
aggatgagaa gatcaggggc gaggcaggtg gcactcactt ggaggcacca gagagaagcg 360
gcagctgctg cctcctaagg gcagggctga cccagaacgc cctcctctac ccacagcctc 420
cccagcctat ctttcctaac tttatagccc tgcttctcca ccaggagggg ctctgttggt 480
tacatgcagg tgaggagagg gatgtccact gacattcatg ctacacccat gggttctccc 540
atttaaacct cacaacatta tcttatgggg aatattagat actattttat agatgcagaa 600
actgaggcac agagaggaaa ggaactagtc caatatcaaa caactgctaa gtgttagggc 660
caagatacaa actctggcag tctgacccca gagccactga ggattacatt ataagggcag 720
gcagagaact ctattcagtc caactgcagc atgagggagt gaggctaggt atcaggaagg 780
acttcttgtt gggcaggtat tttagatcca gatcttggat ctagtctttc tatagctctg 840
atgaaccaaa tagttcggga gttagggaag agggcagatg ggtggggcgc tatccagagg 900
gaagggcata cgagagaagc ggcagaacga gagaggatca gcgcggaggg tggcgggcac 960
tggaccgcag aactggcact cgaggtccca ggggccggaa tgcgcttgga gggagagggc 1020
cgctcagcga gggcgggaca gaacctctcc cgggctggga gtgcacggcg cggtgcgccc 1080
aggtaggctt gggggaaggg tgccgagctc cggaaagttc cacaggtcct ccgcagccct 1140
ggggagcagg acccagaaac cgacgcgacg ggtggggcgc tacccgggcc ggccctaatc 1200
<210>65
<211>1200
<212>DNA
<213>智人
<400>65
tgcagcaccc ggcctccagg tggcaccaat ccgcttactt tgaggtgggc tctgacaacc 60
agctgagctg cccacagtcc ctcagactcc cgaggtcctg ggagcaggga tcaaggtggt 120
ccccaggccg taaacctgac agaggctgca ggagtgcatt tccacccagg gtgcactcag 180
cgggtgtaac tccacacccg tttctttgga gtcaaggccc ggcctctcag tgaggagact 240
gctcctggtt gcccaccgtc gggtcatccc agcctgcagt ggaaccctcc gcagcctggc 300
ctcttccagg gtagcccctc actcccctct ctcctgtcct agcagacagg ccagggaggg 360
tggacgagtt ccagctctgg ggatgtccca tcagctgtgt caccttgaac aaatcatttt 420
gcctcttggg tctcagtttc ctgcagtgtg aaacgtggtg gaggcatgag gggcaatggg 480
agccccaagg cctctttcag agacctcctc tgggtcccat gtgacctcgt ggctgtcccc 540
aaaggcaaga gggtccccag ccctgcggcc aaggccctgg gacaccctat ccaaacaaat 600
gcaggtctct gacgggctga gctttgctcg cttgggtttc tttgctttct tccttttttt 660
tttttctttc ctggatgaaa ttcctgccag ctccgaagga aggagggaag aggagcgagc 720
cgcagtgtag aaagtttcct tgactcctcc tccggctggg tctccctccc ttgccaagcc 780
cagcctgtga aactgaataa cgaagatcac tcaacaatgc ctgcccctct ctgactgcac 840
cgtcccggcg ctcccaccgc cgccgccgcc gcccaataga gcccctgggg cggtccccac 900
cgacggtgca gcccgccggg accgggagga agcagctgcg gccatcgcgc cgtgcgtccg 960
cgcccggccg ccaggtgccc cagtagcccg accgccgaga tgcccagccc gccggggctc 1020
cgggcgctat ggctttgcgc cgcgctgtgc gcttcccgga gggccggcgg cgccccccag 1080
cccggcccgg ggcccaccgc ctgcccggcc ccctgccact gccaggagga cggcatcatg 1140
ctgtctgccg actgctctga gctcgggctg tccgccgttc cgggggacct ggaccccctg 1200
<210>66
<211>1200
<212>DNA
<213>智人
<400>66
tttctcagga aaccaaccat cgggcctccc agacagtatc aaggcgctga aactcagtag 60
gtccttgagg ccagacccct caccagtcat gactgcctag ctgcctcctc actctcccta 120
attcctgttt tcccacacag ggtgacattt cttccctgct ctggaaactt ctaattttag 180
tgggctgagg agagggattt gtgactgagc gcccatctct gggctgtagc acttgaatga 240
ggccttcttc cctggcactg ctgttggtga ttggctttct gtgcagggca gggggcctag 300
atgacaaccc tgatgtttgg gtagcactgt cactgtgaga ggcatggaaa tcctccagtt 360
cttagtcttc ttggaggaag gaattcagac aagagatgcc tagcaagagg tatagggtta 420
agtaaccttt atttaaagag tcaggatctc agagagacaa gacagaacct gccactcagg 480
agatagagcc aaaagctagt gacttaggag gaattctttt ctttctcttt ttttttttat 540
ttttttgaga cagagtctcg ctctgtggcc caggctggag tgcagtggcg cgatctcggc 600
tcactgcaag ctccacctcc cgggttcacg ccattctcct gcctcagcct cccgagtagc 660
tgggactaca ggcgccagga ggaattctta tttgagcttt tagttaagga aaacagtaca 720
gcttgaaaga ggaactgctc aaaagaatga gtcagtcgct actcacgctg gggagaccct 780
cttgatgaga gttttacagg attactcacg aacggcccag gcaggggcct tactagtaag 840
cacgttttgg gaagtcctca gggcacgcag gcaccgtgac ctcacacact agtgcgctgg 900
agtgtgtcat tagcatctgg aatctctccc cagggatgtg gtttttgttt tttttttttt 960
ttttggtatt ataatgagct aaaagctatt caggggcgag ttatcagagg tgagcccgtg 1020
ctcttcagcg gagaagatcc cctacctggc cgccggccac tttctgtggg ccgtggggtc 1080
ctcaaggaga cggcccttgg gctcaggggc tgcgtttcca cacgcgcctt tcccagggct 1140
cccgcgcccg ttcctgcctg gccgccggcc gctccaacag cagcacaagg cgggactcag 1200
<210>67
<211>1200
<212>DNA
<213>智人
<400>67
tgttatatgg atgtattgca tagtggtgga gactgggctt ttagtgtagc catcacccct 60
atagtgtaca ttgtacctat taagtaattt gttgtccctc accccctccc tccctcccaa 120
agtgattaca aatattaatg atgacagtga tgacagaaat tctctccaga tgtgatctga 180
gtttggaggg caaagggatt tttgaaaatg aatcataaga gagaaatttt gcaacaaagg 240
agtgtggtac atttaaattg ctgttttttt ttttaaatac tgtgctcacg cggacctaat 300
aaactatcaa gcagacctca tggaattcca cataatgcag aagcgaggga aaaataggta 360
ttgagggaaa agcagcactg ttttcctcaa ttttaacacg tatgtgcagc ctacacttac 420
aaacttaaga cagtagcttt taacatgtga ctttgctcag ggtaacagac cattctggtt 480
atagccttac ttacagctgt ggaggctgaa tcctgatggg tctaagaagt gtcaggacaa 540
gtgttaggga tgcacctgtc tgtctgtctt aagggaatac gggtctgggc agtcttaaat 600
cggagctccc ttgaggagaa tgtcgtgcag tagccttagg aatgtgaaca ttgggagact 660
ggctgggatt ttgtaggtta tgagttgggg acacttatga tagtgaactt gagcccagga 720
gagaagccat aaaaagtgaa actgtcctgg gcacttggag gtgagtgtct ctctagtaag 780
atgcatgtga aaggctggga gctgaaagca aggagagcag aagaggctgg tgaagattct 840
aatctgcgtg tccaggggca ctcttccagg tctcaggaac gcaggtcaga atgtgcaagc 900
cagctgccgg gcacgtggct cacccctgta gtaccagcac tttgggaggc tgagagagaa 960
gatcgcttgt ggccaggagt ttgagaccag actgggcaac atagggagac cctgtctctt 1020
aaaaaaaaaa aaaaaaaagg actgagtgag ccgagcccag tcctctgatg cactgtgtca 1080
ttcatcccct ttcttaggct gtgttggttc taggctagct gctgtctttc tttggtaggc 1140
tgctaacctc tttggattgt gaatttaaaa catgttttac agtaaatttg ctgccaagac 1200
<210>68
<211>1200
<212>DNA
<213>智人
<400>68
gaactgaggg ctcctcccct ttttagacca tatagggtaa acctccccac attgccatgg 60
catttataaa ctgccatggc actggtgggt gcttccttta acatgctaat gcattataat 120
tagcgtaaaa tgagcagtga ggatgaccag aggtcgcttt ctttgccatc ttggttttgg 180
ctggcttctt cactgcatac tgttttatca gtggggtctt tgtgacctct atcttattaa 240
accagtcttg cccaatttct atctcatcct gtgaccgaga atgcggaccc tcctgggagt 300
gcagcccagc aggtctcagc ctcattttac ccagccccct gttcaagatg gagtcgctct 360
ggttccaacg tctctaacgc ggggcccctg actgctctat ttcccaaggt gtatctagca 420
tctcgcacta tacgaggcca agttaaggct tacacatttg cagaaggaaa gaggtaagga 480
agcaacctgg gaccttccac tgtctctgtt tccatctctc tctttccatc tctgttcatc 540
ccagaatctc tctgtcccta tccctaaata tcgaaaattt ctgtctctga ccatctatca 600
ttgtggctga tcatctgttt ctgaccattc cttcccgttc ctgaccccag ggagtgcagg 660
gtgtcctagc caagccggcg tccctcctag tagtaccgct gctctctaac ctcaggacgt 720
caagggccta gagcgacaga tgtttcccag cagggggttc tgaggctgtg cgcccagatc 780
gcgagagagg caagtggggt gacgaggtcg tgcactgagg gtggacgtag aggccaggag 840
tagcaggcgg ccggggaaaa gaggtggaga aaggaaaaaa gaggagaaaa gtggaggagg 900
gcgagtaggg gggtggggca gagaggggcg ggcccgagtg cgccccccgc ccccagcccc 960
gctctgccag ctccctccca gcccagccgg ctacatctgg cggctgccct cccttgtttc 1020
cgctgcatcc agacttcctc aggcggtggc tggaggctgc gcatctgggg ctttaaacat 1080
acaaagggat tgccaggacc tgcggcggcg gcggcggcgg cgggggctgg ggcgcggggg 1140
ccggaccatg agccgctgag ccgggcaaac cccaggccac cgagccagcg gaccctcgga 1200
<210>69
<211>1200
<212>DNA
<213>智人
<400>69
agctcctgct ctccgctcag tcccacagcc ttcccatgca agagttccgc agcttctcct 60
gacgactcct tcccgcaaaa tccccacccc gtccatcagc aacgctgtgg actctctgct 120
cctgcacctc ccttacctcc cttgtcacac ggagaaggaa gagccggaca ggtacccgcc 180
aggagggctg ctctgtagct gggaacctca ctgagtttgc agcaggggcc agaattgtgg 240
ggagccattc tagagaccgc attttctttt tttctttttt tttttttttt atgagatgga 300
gtcttgctct gtcacccaag ctggagtgca gtggcgcgat ctcagctcac tgcaagctcc 360
gcctcccagg ttcacgccat tctcctgcct cagcttcccg agtagctggg actacaggcg 420
cccgccacca cacccggcta atttttttgt attttgagta gagacggggt ttcaccgtgt 480
tagccaggat ggtcttgatc tcctgacctc gtgatccacc catctcggcc tcccaaagtg 540
ctggcattac aggcgtgagc cactgcgccc gaccaacccc attttcttaa tggtgccgca 600
gattgggaag tggctcccag ggcctcagcc tattggcatg caggccaggc agtgcccagc 660
tgagagtggc tcacaaggat gagtcaggag gaaatgagcg gatggcagga gaggctgcca 720
tctgtggccg cctgcatggc caggcctgtt ctcagcgctt tacagcggcc agttcagctg 780
ctctcacctc agccacctcc cgagagacac gtgggaggtg gaggctcaga gaggggaagt 840
caggactaga gcctgggcat tttgataatg acaggagtga gacgcaggtg gagagcaggc 900
caggagcctg cggcgcttct cctgtgagct gcccccagga ggcgctcgtg tgttgcccat 960
cgctcccacc ccttcttccc tccacatctc tagaaataca gacgctgcgt gcaaagcact 1020
gggtgctgat gtggcttagc atctcctgac acctgtggcc tgtcctccct ccagccgggt 1080
gacacccaga cccccagctc ctgcacaccc ctgggcaacc ctgctgtgcc cccggggtgc 1140
tgagcgtggc tttgccagtg tgtcagaggc atcaattgct aaaacaattc ggcagaaatt 1200
<210>70
<211>1200
<212>DNA
<213>智人
<400>70
tatgtcaaga atgaaagatg gctcatcatt atggaccata cagacgttaa aaggataata 60
aggaaatatg ctgaacaact ttatgccaat aatctgacat ctaataattg gatgaaatgg 120
acaaattcct taaaagaatt accaaagttt attcaatatt accttgataa cttgaatagc 180
cctctagctg atgcagaagt gaatttctca ttaaaaacct tcccacaaag aaatctcgaa 240
gcccaaatgg gttccccagc gaatactacc acaattttta gggaataagt taccccatcc 300
tactcccagg tcactgcagg cccggcttaa accgacccca aaccagacag acacagaaaa 360
cgggaggtcg gccacagagc aatctgcttc accagcaccg tccccaacct tggacaaagc 420
gttaccaagc tgagtcaggc aatacaccaa aaggataacg aatcgtgacc aagtgagttt 480
tccaaggaga gccaaacaat gtaattccct atgggctgaa ataaaaagct acaggatcat 540
ttgaatacat gcagaaaagc gttgcagaaa atttcacacc cactcataag aactcttgga 600
aaaacaggaa tagagggaac ttcctcaact tgataaaaaa caccaacaaa aaacgactcc 660
taacatcact ctgggtggtg aaagcgcact tttccctaat gtgtgggcgg caagaaggcg 720
gacccgctcg aagctccgcc cacccacgcg aggccccgcc cgcccgctcg aagccccgcc 780
cacccggcgg tcacaccgcc ttgcgcgctc ggcatgacgt cactcccacc aggcacctcg 840
ccttgtcagg agctgccagg cgccaaccgc cgacctctga ccgctacggg tcccggctcg 900
cgcaacgacc ccaaggcgca tgcccaggcg cggcgacccc attggtggcg ggcggcggga 960
gcggcgcggg cgcgtgcggg cggcggcagc ggcggtgacg gcagcctagg ccgggcgagg 1020
gccatgctga gcctcgcagc caagctggtg gccttcttct ggaggacggc ggacacccct 1080
agggaggaag ccgggcagct ggagcccgag ctcgcggaag gtggctcgcg ggaggcggct 1140
gggaggcggg tcccgggccc tcgcgtgtcg gccacgaggg agccgcgccc ataggtcttt 1200
<210>71
<211>1200
<212>DNA
<213>智人
<400>71
aggccaggct gggtgacaag ccccccgggt ggctgcacct cccactcgcc gacctgggcg 60
ctgtccttgg tgctgccggc gccatagcga gcacaagcgc cttaccttct gcccctgcgg 120
aagctgcgga cgtcccccaa acgttaaaaa cgccatatcc cactttttat acaaataact 180
accccggcct gttctctttg tccccttccc gaagccttca ggcagaccgt tccgcaaagt 240
cttttttttt gttttgtttt gtcttctaga cccagctcct cggcgctcat ctccagctgc 300
tttaagacaa ggggtggggg aaggggaggg aggcaagaaa agatgagggt gggggagggg 360
aaaagaggga atgcaagggg aaggagggag gagacgggga gaaggaaaga ttggaagaaa 420
aggatctccg aggaaggggc tgagagaagg gcagggtgaa ctggactaaa ggccagagta 480
ggaaggagaa gaggggccaa aaaagaaggg gatgaaatta agcacagaag atgggtaaag 540
aaaaaagtat cagggaaagg gcaaaataag agaaagcctt gaggataaga gggtagaagg 600
ctaaagaaca aggggaccac tgggtcgggg aagcgctgcc tgaacggcgg gacagtgaca 660
aagaaagggc gctggcgata ttcgcaccaa gggtgcgaaa cgcaatcggg aggtgagaaa 720
tggaaagaag gcgaatgccc ggctacaagt agcctgggac tgaaagggga cctgggggag 780
gggctgggcc cagggcagaa aagtccaggt tcccatgcgg cctgggccca cgtggagcgg 840
gcgctgaatc accgttcagc cgcccccctc ccctcctccc cgaccggtgc ccgcagtccc 900
cgcctcctcg gccgccgcct ccacggggcg gggccctggc ccgggaccag cgccgcggct 960
ataaatgggc tgcggcgagg ccggcagaac gctgtgacag ccacacgccc caaggcctcc 1020
aagatgagct acacgttgga ctcgctgggc aacccgtccg cctaccggcg ggtaaccgag 1080
acccgctcga gcttcagccg cgtcagcggc tccccgtcca gtggcttccg ctcgcagtcg 1140
tggtcccgcg gctcgcccag caccgtgtcc tcctcctata agcgcagcat gctcgccccg 1200
<210>72
<211>1200
<212>DNA
<213>智人
<400>72
agaatgactt ctgtttccct tcctgaaggc ttcttggtgc agtgttgagc tacaggaagg 60
cactagccac atgagcaggg cccttgctga aacccccttc ctccaggaag ccttctttga 120
ctgccatagg ctgcagaggc tcctctcccc caccttgtta tagctaacag aaccactcag 180
ttcagagctg gtggtcttct gatgatctgt cccggagatc tgttccctca gcttggccag 240
agctccaggc ttgtgagtct ggtccgcggg cattcaaagg ccctcagtgg catctgtgca 300
tcagtgagac tgcccggggt tcctgctctg aacccttgcc ctagtgcccc tagcctggct 360
gagaacggag ggtcaagtgc cggggttcta atctcaatta ctttatccaa gcatccgctc 420
gctcatttac atgtttccct gggctctcca ctctgcgcca ggcccggtac ctggagctag 480
ggaaaccgaa cattagtgct ggctcgcccg cccccgcatc cggggagctc ggcgttctcg 540
cggccctgct ccccttgttt tcaagtgcaa gttccatgtt tccgtgctgg gaataaggcc 600
agccccgggt gccaccatac tcgcctgatg tcttaccccg acccgcgccg ccgagagctt 660
gcggctacgg gaacgcggcg cgccccgggg ccacatctgg cctagcgggc gcgcgcgtgt 720
cactaagacg ctcattcacc ggcgcagctg tcaccataac aaccggagcg agggaatcct 780
ggagactgcc ggggcggggg gcgggggcgg cggtcgcagg agggacccgg cgcgggcggg 840
accgcggcgg tcgggggaca ccagctgcgt cggagcgccc agaacgcccc gcgctccgcc 900
gagccccgct ccacgcagac ccgcgggcgg gagggagcca cgcacatcgc cgccgcggcc 960
gtctccgcgg ggcggtaacc gagcctgcct cggagccgcc gaacgcccac gccagcgacc 1020
ctgactctat ggccccgggg gagcgcgccg gagccgccgc gccgcccacc cccagccgga 1080
accctagcgt cccggggagc aagcggggag ccccgggcgt ccccggcccc ggcccagggc 1140
cctgcttgtg gcccccgctc ccgccacggg gcatgggagg caggtagccc agcctgcgcc 1200
<210>73
<211>1200
<212>DNA
<213>智人
<400>73
cccggggttc ctgctctgaa cccttgccct agtgccccta gcctggctga gaacggaggg 60
tcaagtgccg gggttctaat ctcaattact ttatccaagc atccgctcgc tcatttacat 120
gtttccctgg gctctccact ctgcgccagg cccggtacct ggagctaggg aaaccgaaca 180
ttagtgctgg ctcgcccgcc cccgcatccg gggagctcgg cgttctcgcg gccctgctcc 240
ccttgttttc aagtgcaagt tccatgtttc cgtgctggga ataaggccag ccccgggtgc 300
caccatactc gcctgatgtc ttaccccgac ccgcgccgcc gagagcttgc ggctacggga 360
acgcggcgcg ccccggggcc acatctggcc tagcgggcgc gcgcgtgtca ctaagacgct 420
cattcaccgg cgcagctgtc accataacaa ccggagcgag ggaatcctgg agactgccgg 480
ggcggggggc gggggcggcg gtcgcaggag ggacccggcg cgggcgggac cgcggcggtc 540
gggggacacc agctgcgtcg gagcgcccag aacgccccgc gctccgccga gccccgctcc 600
acgcagaccc gcgggcggga gggagccacg cacatcgccg ccgcggccgt ctccgcgggg 660
cggtaaccga gcctgcctcg gagccgccga acgcccacgc cagcgaccct gactctatgg 720
ccccggggga gcgcgccgga gccgccgcgc cgcccacccc cagccggaac cctagcgtcc 780
cggggagcaa gcggggagcc ccgggcgtcc ccggccccgg cccagggccc tgcttgtggc 840
ccccgctccc gccacggggc atgggaggca ggtagcccag cctgcgccag gacacccgtg 900
gcgggcggaa cccgccaagg accgcgaagt ccagagaaag gaagctgagg agctgcccgc 960
ccgcccccgg ctgcagcccc agcagggccc tcccccggtg gcgcgcaccc gcgcgcgcac 1020
actcgcacac cgcacctcag cgcctgcccg gcctcgcccc cacccgcgag cgccgaacct 1080
cctggggccg gatgccatgg gtaacaactt ctccagtatc ccctcgctgc cccgaggaaa 1140
cccgagccgc gcgccgcggg gccaccccca gaacctcaaa ggtaggctcc ccggccgagc 1200
<210>74
<211>1200
<212>DNA
<213>智人
<400>74
tgctcccaag tgcttatgag cccatgtata tgcacatttg tgtgacatga tgcagaagaa 60
tagtgcaggt ctgtgttggg gtgtgtggtg tgtgtgtatg tgcatggtta aagggatagg 120
ttggtgtggg ggggaaaagc ctggattctg gtgctgcact gcctgggttt gcattccagc 180
cttgccacct tttaggtgag cagcctctct ttgtctcagt tttctcatct gtaagaccat 240
catcatcatc ttagagatgg tacctgttga tctgttgata atgactgtaa tactgacctc 300
atcattcagc ctgtgaggac caaaggagtt aatacttgca aagcccttgg aacagagcct 360
ggaagaagac agaaacggtg ttagcacttg gttaacagct ccatcagctt gattgtgaac 420
ctcttgaggg cagggacgat gtctgttttg cttcccaggg ggtcccctct cacctagcag 480
gacctctgca tgtagtaggt gcatgaggct agtgaatgaa tggctgtcgg cctgggcgtt 540
cagggagggc tgtgtgtgtc actacatccc tgagatgggg ctgtgtgtga tggggatgtg 600
tgtgcgtgtg cgcgcctctg ctcgctttct ggagctcgct gctatttcag gaagcctcca 660
gtctcctcct ccttatgtaa ataaacatga cagatcccat cggctgtacc agcgcgggag 720
gtggggaggc tggagtgggt gggagcgggg aggcggcggc cggaggggtg tgcgtgctgc 780
gtgcgcgtgt ggccggctgg ccgcgggcgg gcggcgtgcg cgtgtgccgg agggggcgcg 840
tgggggcgcg tgggggcgcg ggaggggcct cggccctgcc atgccggtct ccgcccgcgg 900
gggaggagac gggggaggag gaggggagca gccggccggg gcgactcggt gaccagccgg 960
ccggcccagc agaggtggct gcactgcccg tcgccggaga tggggggaca gatcacccgg 1020
agcactctcc acggtaaggc cccgcggatg cctgcgggcc cgcccacccc agcccgagac 1080
cgcctgggga ggccgggcgg aggggcgctg gggctgaggg cttggtcatg cccctacttc 1140
tcactccatg gaggggtctg gggctgtgtg ggggcacctt ttggtggtgg gcactggggt 1200
<210>75
<211>1200
<212>DNA
<213>智人
<400>75
gaccgcctcg gcctctcaaa gtgctgggat tacaggcgtg aaccaccatg cccagcctat 60
ccttttgttt tccatcctgt gttggcttgg tgggggagag gaggtgttga cacgtggagg 120
acacacatat aaggcattct tgggtgactt cgtcatcact ggaccctatc tctcaaaatt 180
ccagcgaaat ctgctcttcc ctttaaggag tgaaagaagg gtcagcattc cagaagttcc 240
tggtcatacc caggctttta atgaattgcc actggggaat cagcatcccg ttgctgtaag 300
gactataaga tggcggattg tgagagcata gggaaaggtc tcggaggtct cttgtccttg 360
ctccacgcag gtctttctgg cctgaaaatc ccgttgaaga gagcagctct tgagagtttg 420
ctccaagttc cctcggggtg atcagcacca cggacagcgg ccagggcgcc cccgaggacc 480
cgcaggcagg cagggtgcac agcggcgagc aggtgctgcg ctacgtgcgg gccagggaac 540
tcgcgcgggg aggggagagg cgccgcgggt ggcggggtct tggccggggc tgttttcgct 600
gtgagtcacc ccgtgctccc cgcgctcacg tcggtcctcg gaaagccggg gtcctccctg 660
ccttttccag caacggtggg gtggggaggc aggaagaaag cgccaaccta ggacacctgg 720
acatttgcag gaaaggaaga agcgggagac ggggacttgt ctgtgtctcc agcgcgttcc 780
tgccccccgg cccgacccgg cccatttcta tacaaggtcg gctctgcccg gtctccacct 840
cccacgtcgc aggcgcggag gggctcattc ccgggccctg atctcagagg cccggaatgt 900
ggctgataaa tcagagataa ccctgcatgg cagggcaggc ccgacactca gctccaggat 960
aaaaggccac ggtgtcccga ggagccagga ggagcacccc gcaggctgag ggcaggtggg 1020
aagcaaaccc ggacgcatcg cagcagcagc agcagcagca gaagcagcag cagcagcctc 1080
cgcagtccct ccagagacat ggatccccag acagcacctt cccgggcgct cctgctcctg 1140
ctcttcttgc atctggcttt cctgggaggt cgttcccacc cgctgggcag ccccggttca 1200
<210>76
<211>1200
<212>DNA
<213>智人
<400>76
aggaaagttc tggcatttgg cagattaagc aagtgtcttg atttgaagtc cagtttagtc 60
ccaatactcc ctcccacacc caccacatcg cacaatttgg ttttgtttat ttactccagg 120
ttaaggtaga gtctcttagc ttggtttgag tgctgtactc ttctctctgg tctgatattt 180
ggaactaaag ccaagccaga actccagggc caagggggat gttgaaaatt gtctgagtcc 240
ccagaccacc ctgccagctc atggcaaagg gagggatcag aggccacagg gaaagcactt 300
cagctgctct tcacagcatc accctctccc catttaatgg tttaggttaa caggactttt 360
tccttgaggc ttgggacacg gaagggagcc tcccctaaac caggcccttg gagagcaggc 420
cccaggggag cagtgcaact caccttcaca cccacaagac ggctcctgac ttctgctccc 480
tcctcccctc cccaaagtgg aacagagaga atatgattcc ccacgacttc cacatcacag 540
tttccaaaca atggggaaat cggaggcctc cccgtgtgca gacggtgata tttaccgcca 600
aatgcgaacc aggcagatgc cagccccagc acgcacgcag gtaacttcac cctcgcctca 660
acgacctcag aggctgcccg gcctgcccca cacgggggtg ctaagcctcc cgcccgttct 720
aagcggagac ccaacgccat ccataattaa gttcttcctg agggcgagcg gccaggtgcg 780
ccttcggcag gacagtgcta attccagccc ctttccagcg cgtctccccg cgctcgtccc 840
ccgtctggaa gcccccctcc cacgccccgc ggcccccctt cccctggccc ggggagctgc 900
tccttgtgct gccgggaagg tcaaagtccc gcgcccacca ggagagctcg gcaagtatat 960
aaggacagag gagcgcggga ccaagcggcg gcgaaggagg ggaagaagag ccgcgaccga 1020
gagaggccgc cgagcgtccc cgccctcaga gagcagcctc ccgagacagg taagggcgca 1080
gcgtggggga cccgtgctct ttccccggga tcccctgtcc ccgtcctcgc gatgcagtcg 1140
gccggctccg gctccgaagg cggacctggg cgcctctggc tctccgcggt cccgagttct 1200
<210>77
<211>1200
<212>DNA
<213>智人
<400>77
gacggagctt ggatctctct tgtggtccaa agggaaagga ttgctgaatg taaagccaat 60
gtcaccagaa aagctgaatc cacaagagag tcctggagtc caaaagagca tctcatgggg 120
aatcaggaaa gttctggcat ttggcagatt aagcaagtgt cttgatttga agtccagttt 180
agtcccaata ctccctccca cacccaccac atcgcacaat ttggttttgt ttatttactc 240
caggttaagg tagagtctct tagcttggtt tgagtgctgt actcttctct ctggtctgat 300
atttggaact aaagccaagc cagaactcca gggccaaggg ggatgttgaa aattgtctga 360
gtccccagac caccctgcca gctcatggca aagggaggga tcagaggcca cagggaaagc 420
acttcagctg ctcttcacag catcaccctc tccccattta atggtttagg ttaacaggac 480
tttttccttg aggcttggga cacggaaggg agcctcccct aaaccaggcc cttggagagc 540
aggccccagg ggagcagtgc aactcacctt cacacccaca agacggctcc tgacttctgc 600
tccctcctcc cctccccaaa gtggaacaga gagaatatga ttccccacga cttccacatc 660
acagtttcca aacaatgggg aaatcggagg cctccccgtg tgcagacggt gatatttacc 720
gccaaatgcg aaccaggcag atgccagccc cagcacgcac gcaggtaact tcaccctcgc 780
ctcaacgacc tcagaggctg cccggcctgc cccacacggg ggtgctaagc ctcccgcccg 840
ttctaagcgg agacccaacg ccatccataa ttaagttctt cctgagggcg agcggccagg 900
tgcgccttcg gcaggacagt gctaattcca gcccctttcc agcgcgtctc cccgcgctcg 960
tcccccgtct ggaagccccc ctcccacgcc ccgcggcccc ccttcccctg gcccggggag 1020
ctgctccttg tgctgccggg aaggtcaaag tcccgcgccc accaggagag ctcggcaagt 1080
atataaggac agaggagcgc gggaccaagc ggcggcgaag gaggggaaga agagccgcga 1140
ccgagagagg ccgccgagcg tccccgccct cagagagcag cctcccgaga caggtaaggg 1200
<210>78
<211>1200
<212>DNA
<213>智人
<400>78
ggattacagg catgtgccac caggcccagc taatttttgt atttttagta gagatggagt 60
ttcaccatgt tggccaggct ggtcttgaac tcctgacctc gtgatccacc ctccttggcc 120
tcccaaagtt ctgggattac aggagtgagc cactgcgccc agccacattt aaattttaga 180
gtataattat tgctgcttat aattagaagt gagaagactg ttttgaagta agggacttcc 240
ctggccaccc tcgctaaaat tgcaacctta ccctcactcc atttctcctt ctctgcttta 300
tatttctcca aagcacttat atgataataa actgtataat accgtactta ctgtgtttct 360
catgtatccc ggctacaact gtcaactgcg tgggactggt tttgtctgtt ttgttccctg 420
ctctatccct ggagcgtaaa gcagtgtctg gtatagagtg gatacttaat agatattcgt 480
tgaaccgggc cagtggcggt ggctcacgcc tgtaatccca gcactttggg aggcggaggc 540
aggcagatca cttgaggtca ggagttcgag gccagcctgg ccaacatggc gaaatcccgt 600
ctctactaaa aatacaaaaa ttagccgggt gttgtggtgc atccctgtaa tcccagctac 660
ttcggaggct gaggcaggag aatcgcttga acctgggagg cggacgttgc ggtgagccga 720
gatcgcgcca ttgtactcca gcctgggcga caaagagaga catcgactca aaaaaaaaaa 780
aattcgttga acggaatgag tgaacaaaca aatggatgga tgagtgaatg aatgaacgaa 840
ggaacaagtg accgctcgac cttctacagc gacagcggcg caggcgctcc cgcaccaaca 900
gccccccacc ccgccaccgc cagagggcgc agacaggccg ggtcccgagt gtctgtccca 960
ggcccccgcc ccacaggatc ccggcccggg agcccccgat gcagggaccc gcccgggact 1020
ctgggtcccc gcccatacct caacttcgca cgactgcgtg cctcaagccg acgcagcggc 1080
ctactctcgc actgcagacg gggaaactga ggcctgaggc ggccggggtg gggcagacct 1140
cccggcgagc ccgagccccc gcccccggct agccccgccc tggcccgtaa gaagcacccg 1200
<210>79
<211>1200
<212>DNA
<213>智人
<400>79
aataaacttc catgttgttg ttgttgtttt gaaacggagt gtcactctgt cacctgggat 60
ggagtgcagt ggcacagcct tggctcaccg caacctccgc ctcctgggtt caagtgattc 120
tcctgcctca gcctcctgag tagctgggat tacagatgca cacgaccacg cctggctaat 180
tatttgtatt ttgagtagag atggggtttc accatgttgg ccaggctggt gttgaattcc 240
tgaccttaag tgatctgcct gccttggcct ccccaagtcc tgggataaca ggcatgagcc 300
actgcaccca gccaaacttc gaggtatata attaaaagtt taataagccc tcagcctaat 360
tttaaaattc agattctttc tttctttctt tctttcgttc tttctttctt tctttctttc 420
tttctttctt tctttctttc tttctttctt tcttctttct ttttctttct ttcttgataa 480
cattattatc atagtctggt agattctgtc tttctataat aaaaatcctg tgatgttgtt 540
caaagaaact caatgggctt tctgtatgtt taccaaggaa ttaaaatctt aacaaaggtt 600
ttcaacacaa gaaatactcc cttttgtaag aattcttcat aggtttttct agcacaagtt 660
tgtttttatt gaatgatact tgatggttct gtatgttatt tcttttctac tacatataat 720
tttgattagg ggatacatta aatattttaa aactatcatt tctttttcca gaacaatcat 780
aacatgtttt gcttcttgtt gctttaaaag gaacatttta agttgctttt ttacaacaat 840
aagtgtgaaa ggaaatgcca aaatacaaac aatttcactt cttgttggaa tttgacattt 900
ccactagcta agtaatataa acatgcatca cctaaatgag cagtatttta atagcatcgt 960
tttcacattt taattgttgt cacatttctt ctttgtttag ggagacgtct ggtgaacacc 1020
cgtgggatct aaagaacaag taagatttaa agcatactgg gttgtgtgcc tggctttcac 1080
attttattta ttttattgct taatagtgtt tctttactac tgtgggttgt agcttaaaat 1140
tgttagaaat tttattatgg agtataagga ataaaagtga acgttcaaca ctttcaaatt 1200
<210>80
<211>1200
<212>DNA
<213>智人
<400>80
cctgcctttg catagaattc ctggaatgcc ttttcgtcat cttgttaaaa tcctggttaa 60
acttcaaggc ctagtttgag acactatttc catgatgtca gtcttgatcc tatcttttat 120
agcattatct ggttttcctt cctggcgcta atcacttatt aaattgtact aatcatctgg 180
tgtacctgct ttattttccc tactaatctg gaaacaaaaa taatagaacc tgactcatct 240
ttctgccttg agacaccttg tgctgtcact cttgatgcct tgcacacagt aggtgctcta 300
aaaatagttt gtggcttttt gattttacag agaagactga ggaaattaaa cccttgccca 360
ggaggcatat aaaaatcctg ttaaatgaaa gaggctcatg ctaactattg ttttgactta 420
ttgatgccaa actagacttg aacattgatg tgtcttcagg gaagaagcca aatatgctag 480
tgtaaaaaat tctaacctct gctatttacc tggagaagtt gaattagccc tgtcatttca 540
actgatgcca aaaaagcagc ttccattatt gtgtcagtaa tagactttta tcctgcatgg 600
aggaacttct cttaaatctt tctcatagca ctggtgtgct tctttgcact gatgtattta 660
cgtaatgttt cataagaagt gacagttcct tttttaggtc tttgcccaaa aggtggcata 720
agcaaagaat gaaagtcaag gtggttggct ttaggagagc ctaaaattgg gaatgcgaga 780
gctcccacgt aacacaaacc cggatagtct aagactccta cattttacaa accaagttat 840
ttccttccta atacaaacaa agtatgacag ttacaattta ttgtgtattt acaatggatt 900
gtgtctgtca tggtgattgt gatggaacca ggggggaaag agtaagaaat ctaagcactt 960
ttgtgttttc ttccttttct tttctcttcc tccccgcttt caggctctga aagtgttcca 1020
gctgaaattt cagatcggac agactcgctg cggctccgga ggcagtgatt ccaagctgct 1080
cgcgcacgct gctgccaagc tgcaggatgg tgcacgtagc caggctgctg ctgctgctcc 1140
tcactttctt cctccgcacg gatgctgaga gtaagccatt ctccccttct ctagggggct 1200
<210>81
<211>1200
<212>DNA
<213>智人
<400>81
aagcaaacct agataaatgg gacttcatcc aactaaaatg cttctgcacc gcataggaaa 60
taatcaacaa aatgaaaaaa cagcctatag attgggagaa aatatttgtg agccatatat 120
ctgataaggg gttaatatcc aaaatacatt acgttcacag aactcagcca aaataaataa 180
ataaaacacc cagttaacta acgggcaaag gatgtgaatg gacttttttt ttttttccag 240
aggaagtaca aattgccaac aggtataaga aaaggcgctc aaaatcacta atgaacaggg 300
aaaagccact aggtatctcc tcacacctgc taggatgact gttataaaaa agataagcga 360
taataagtgt cggtgatgtg cggagcaaag ggaaccttgt acactggtgg tgggaatgcg 420
gactggaaca gccattatgg aaaaccctac ggaggttcac tcaaaaagtt aaaaacagaa 480
ctaccagccc agtgttatcc gtccttcgtt aagttcaaag tcacggtgcc acttcctttc 540
ccatctaaag gggactgctc gcgacccaag ccaaggcccg caagtgtggc tctccctgcg 600
gggagagtag ggcaggaggt ggatttccag gccagaggct tccaggctgg gcccggaccc 660
cacgccgacc ccggccccgg ggggggctca gcgacctcgg cgcctcctca ggcccccagt 720
gaacctccgg ggcccataaa ggctccaggc cggctccccg gaggcccacc agcgggcgtc 780
tgggcctccc tccgcgccgc gaccgccagg aggcgccgcc cgggagagga agtccagctg 840
ggcccggccg ggcttcggag gcgccgcccg ggagaggaag tccagttggg cccggccggg 900
cttcagaggc gcagggcggg agccgcctcg cgcagggtcc tccccaagcc ggcgccaggc 960
cctgccctcg tccggccctg ccctcgtctg gccccgcccg ggccgcgagc actggcgggt 1020
tctgggtcct gtgaccggtc aggcggcgtc agcgggcgcg gcggagggct ggccggcctc 1080
gggggagttt ccgcggccgc cgggggcgcg gcggcagagc gcgaggccgg gcagggggcc 1140
agactcggag tcgaggcgcg cccgacagcc gcagcgctca tggcgggcgg aggagccggg 1200
<210>82
<211>1200
<212>DNA
<213>智人
<400>82
agcaaaccta gataaatggg acttcatcca actaaaatgc ttctgcaccg cataggaaat 60
aatcaacaaa atgaaaaaac agcctataga ttgggagaaa atatttgtga gccatatatc 120
tgataagggg ttaatatcca aaatacatta cgttcacaga actcagccaa aataaataaa 180
taaaacaccc agttaactaa cgggcaaagg atgtgaatgg actttttttt tttttccaga 240
ggaagtacaa attgccaaca ggtataagaa aaggcgctca aaatcactaa tgaacaggga 300
aaagccacta ggtatctcct cacacctgct aggatgactg ttataaaaaa gataagcgat 360
aataagtgtc ggtgatgtgc ggagcaaagg gaaccttgta cactggtggt gggaatgcgg 420
actggaacag ccattatgga aaaccctacg gaggttcact caaaaagtta aaaacagaac 480
taccagccca gtgttatccg tccttcgtta agttcaaagt cacggtgcca cttcctttcc 540
catctaaagg ggactgctcg cgacccaagc caaggcccgc aagtgtggct ctccctgcgg 600
ggagagtagg gcaggaggtg gatttccagg ccagaggctt ccaggctggg cccggacccc 660
acgccgaccc cggccccggg gggggctcag cgacctcggc gcctcctcag gcccccagtg 720
aacctccggg gcccataaag gctccaggcc ggctccccgg aggcccacca gcgggcgtct 780
gggcctccct ccgcgccgcg accgccagga ggcgccgccc gggagaggaa gtccagctgg 840
gcccggccgg gcttcggagg cgccgcccgg gagaggaagt ccagttgggc ccggccgggc 900
ttcagaggcg cagggcggga gccgcctcgc gcagggtcct ccccaagccg gcgccaggcc 960
ctgccctcgt ccggccctgc cctcgtctgg ccccgcccgg gccgcgagca ctggcgggtt 1020
ctgggtcctg tgaccggtca ggcggcgtca gcgggcgcgg cggagggctg gccggcctcg 1080
ggggagtttc cgcggccgcc gggggcgcgg cggcagagcg cgaggccggg cagggggcca 1140
gactcggagt cgaggcgcgc ccgacagccg cagcgctcat ggcgggcgga ggagccgggg 1200
<210>83
<211>1200
<212>DNA
<213>智人
<400>83
aagtgcccac ccaaatagcc tcatcattgc tgagggtctg tacatgacag tgactggggc 60
gtaggcagct gcacacacca gggctgagtc ccagcacacg tgttctacct gtgtgactcc 120
gagccttact tttctcatct gtacacagtc tctgtctcaa ggctattgga atgagtcaat 180
gatagagtgc acgtaaatca cttgcacaga gagttgttca aacaatggta gctagaactg 240
ctattgatct attgtggggt aattgtctta actgctttga aggattcagc cctatgtgtt 300
cctttgtcca gtcagatggg aaaatataaa tgagcccttc tcaatgttag gaatgacaag 360
atcaggccaa gacccctctt tctcagacta tccggaagat acacagatga cctggacagt 420
gtctgcaggc tcctgtgtat cctgaggctt cctgagggcc aagttctatg ggtgggaagg 480
cagcttgctc tctaggttgc cataactctg catctgattt gcatgtgttt gtggtgaccc 540
tgcagtttct tctggcattt ccaacttaaa atattgctgt ttccccaggc agggcagata 600
ttgatttttt tcttctctaa ccattccgat tgacccggct cccccaccca gcgaatgggg 660
gagggagggg gtgggggtga ggaagtggat gggggagaag ggaggaggga tggtgttgcc 720
cttatagcta gcacctttta ctccgtggaa cctgagtcac cggggctgat gagaatgggc 780
tctttccaga agcaagtgca tgatgaagaa agaacagagg gaatgttccc cctcgggtcc 840
atcctggtcc cttctttccc tgcatccctt atatgacctg cagttccctg agtccacttg 900
ccaccggggg cgggtggcac ccaggcggcg gggaggcggg ggaggggcgc agtgacagcc 960
gagccggctt tgaggaacct tgcagaggaa gtggcttcag aactgcttta cgcgaggggc 1020
aggaaaggcg cgggaggcgg gggaggtgcg gagatggcgc tctgcacggc ggcggaggga 1080
gggcgctggc gccggggaca cgaaaccgca gagcccggac gagtcaggga gtgaggcgcg 1140
agccgggcgc ccggggctct gcaggcgcag gcggcgcggg gacaggagca ggttaccggg 1200
<210>84
<211>1200
<212>DNA
<213>智人
<400>84
cttgaagcaa gccttcacgg gggaaagtgc cgggagaaag gagatctctc tttgggtccc 60
atgagtgaac catccatacc aggttccact tagggcattt aggggaactg gtatctccac 120
agtaattact agagcagctc tggggaacgg agggttggct aaggaagaaa agctccccca 180
acccttgggg cgagggagcg ttctctcaat ggagcccccc caactcccct ccacccccca 240
ccagtcttcc aggaaagagg aataccctac ccggcagggc tgcgaaggaa ggggaaatcc 300
aaccagagcg aaagtcgcac gcggacagct ctgccagccc ttggaggcat ccggcggtca 360
cccacgggac aaagcgcggc tgcgggagcg cgcgcggggc attccggacc cgcgtcgagc 420
tccgctctag agggggcggc gggcggcgac aagccggaga gaggaagggc caaggagcac 480
ggccctcctg tcggcaccat cagcgggaga gtggcgagcg gacgcctaga cggaggggcc 540
ctactcagac cccatcgagc cagttcccaa gcttttccct ccgacctgct ccctcccggg 600
gcgcgtgagg gtgcgggtcg ggggtgaacc tggtgttggg gaaagtgatt ggcaagggaa 660
agaggcaggg ctgaaggcct agggcccccc gcagaaatgc gccctctgag ctgtactgta 720
cagaggcgct cctctgcgga atcctgcagc tgctccaggt gaagacgccc ccaaatccac 780
actcgcgcag acgtcgcctg gcacggaccc tacccccttc ggtccgtcgg cggttctctt 840
gggtcgtcct tcctgccact ccgactctcc ccgcccccgc cccgcccagc aggctgcggt 900
tcctttaaag gcgcgctggt gtggggcggc cccttctctc ggggctggct cgggagtagc 960
gcagtcgcca aagccgccgc tgccaaagct gccgccacta gccgggcatg gccatggcgt 1020
ccccggccat cgggcagcgc ccgtacccgc tactattgga ccccgagccg ccgcgctatc 1080
tacagagcct gagcggcccc gagctaccgc cgccgccccc cgaccggtcc tcgcgcctct 1140
gtgtcccggc gcccctctcc actgcgcccg gggcgcgcga ggggcgcagc gcccggaggg 1200
<210>85
<211>1200
<212>DNA
<213>智人
<400>85
ttcaagatgg tgaccgcaga gcgttaaacc agacaagggt ccatgaaggc ttgaagcaag 60
ccttcacggg ggaaagtgcc gggagaaagg agatctctct ttgggtccca tgagtgaacc 120
atccatacca ggttccactt agggcattta ggggaactgg tatctccaca gtaattacta 180
gagcagctct ggggaacgga gggttggcta aggaagaaaa gctcccccaa cccttggggc 240
gagggagcgt tctctcaatg gagccccccc aactcccctc caccccccac cagtcttcca 300
ggaaagagga ataccctacc cggcagggct gcgaaggaag gggaaatcca accagagcga 360
aagtcgcacg cggacagctc tgccagccct tggaggcatc cggcggtcac ccacgggaca 420
aagcgcggct gcgggagcgc gcgcggggca ttccggaccc gcgtcgagct ccgctctaga 480
gggggcggcg ggcggcgaca agccggagag aggaagggcc aaggagcacg gccctcctgt 540
cggcaccatc agcgggagag tggcgagcgg acgcctagac ggaggggccc tactcagacc 600
ccatcgagcc agttcccaag cttttccctc cgacctgctc cctcccgggg cgcgtgaggg 660
tgcgggtcgg gggtgaacct ggtgttgggg aaagtgattg gcaagggaaa gaggcagggc 720
tgaaggccta gggccccccg cagaaatgcg ccctctgagc tgtactgtac agaggcgctc 780
ctctgcggaa tcctgcagct gctccaggtg aagacgcccc caaatccaca ctcgcgcaga 840
cgtcgcctgg cacggaccct acccccttcg gtccgtcggc ggttctcttg ggtcgtcctt 900
cctgccactc cgactctccc cgcccccgcc ccgcccagca ggctgcggtt cctttaaagg 960
cgcgctggtg tggggcggcc ccttctctcg gggctggctc gggagtagcg cagtcgccaa 1020
agccgccgct gccaaagctg ccgccactag ccgggcatgg ccatggcgtc cccggccatc 1080
gggcagcgcc cgtacccgct actattggac cccgagccgc cgcgctatct acagagcctg 1140
agcggccccg agctaccgcc gccgcccccc gaccggtcct cgcgcctctg tgtcccggcg 1200
<210>86
<211>1200
<212>DNA
<213>智人
<400>86
tactcaggag gccaagacac gagaatcgct tgaacctgag gggatggggg gcagaggatg 60
cagtgagccg agattgccga gatagcgcca ctgcattcca gcctgggcaa cagtgagagc 120
ctccatctca aaaaaaaaaa aaaaaaatgg acttcttcct cattgacctg tggtggctcc 180
aaggccatca aaaaaaaaaa aaatggactt cttcctcatt gacctgtggt ggctccaagg 240
ccatcatctc acagcctttt tttttttttt tttttttgag acggagtctt gctcccttgc 300
ccaggttgga gtggagctgc atgatctcgg ctcactgcaa cctccgcctc ccaggttcaa 360
gcattctcct gcctcagcct cctgagtagc tgggattaca ggcgcgtgcc accacgccca 420
gctaactttt gcatttttaa tagagacggg gtttcaccat attggtcagg ctggactcga 480
actcctaacc tcatgatccg cccgcctcgg cctcccaaag tgctaggatt acaggcgtga 540
gccactgcgc ccggcctcat ctcacatctt tcttcctctg cagcacacga cacgccctag 600
ttggaaacaa agtcggagtt tgtggattgg gggaagggcg gggtctaacc tcaggtcagg 660
cgccgtgcaa ggtacatctt ggcacccgga agaggcccag tacagttgcc cccgaggtga 720
cccgacctcc cctaccaatt gaggcgccct tgttgccagg cttgcggcgg gggagcggcg 780
ggggagcgac ggggatgcgc tcattggtca aggaaggggc gcctgttact agaggcgaga 840
accggagccc attggtcgga acacctcaca atggacccca gcggcgcgca aaatccttat 900
gattggtttg ctggctgcct cgggagaccc tgttgccagg atacttggcg ttcccgaccc 960
gacccccgtt ccccattggc tgtcagggca aaagccgcca tctaatgagg agcgaggtgc 1020
ggtgccccga agcgctcgct tcccgcggtg cgatctagtc ctgcagtagg cggcccgggg 1080
ccacaccgcg gccgcccaag ccagtgcaag gcccaggggc ctgacatcgc tcccagcgct 1140
cgaggaccga ggcctgctgt ggaggacacc gtgctccctc gggacctgct ctggattccg 1200
<210>87
<211>1200
<212>DNA
<213>智人
<400>87
caaaaagcag ccggggatgg ggcgagaaca gaggacttcc ccactgagcc cacatccaac 60
ctcacccaga accccttctc aggtccagtt gctgctccct attaggggta aatgtgttta 120
tgcgcatcat ttccatcatt tctttggggg aaaattggat tctttcctcc tcctcgctac 180
tcgctctccg actctgccag cccatctcct gagagttctc ctgtgtaagg gatgcaaggg 240
ccaccagcac caggtctctg aaaggacgcc ggagccagtt tccggtttcc aagggttgga 300
ccagtgctgg aggggggaat cacaaactgc ccttccagga ccctaccctc tctactaccc 360
caggatgctg aaaaaggcta ttctgcctct cttcccctgc tcagctcttc cccgcctcct 420
gcctccggcc ccagcagagg ccgcgctccc actgcgcctc tcgcctctga gaaatggcgc 480
agcaagcgct ccgcggagag cctggaggcg gggcgccctt ctctgagtcc gcggggtcgc 540
accccgagcc agtcggccag acctgcatcc cgcgtagcat ccctgccctc tctgtgcagc 600
ggaaagggca aaaggcaggg actgcaagcg ggcgcgcacc gggtaggaag agcggctctg 660
cgtaggtgcg cggacccggg ctcctgggtt ccatccccgc cgcgcacctc ggggtccgca 720
cccggctcct gccgggccct tttcggccgc accccgctcc cgcaccccgc tcctccccaa 780
gccccacccg gcccaagccg cgcgtcccgc actgagctcc tacacgcgcc gcgccccggc 840
cgcaccccgc gcagccagag caagcactgg agccccgccc cttcccgcac cccacccgcc 900
tccggccccg cctggcccac ccctggaccg cccccgcccc gccccgcccc tacccgctcc 960
tccggcgcag ccggcgctta cctcgcttca gtcccgcgac cgaagcaggg cgcgcagcag 1020
cgctgagtgc cccggaacgt gcgtcgcgcc cccagtgtcc gtcgcgtccg ccgcgccccg 1080
ggcggggatg gggcggccag actgagcgcc gcacccgcca tccagacccg ccggccctag 1140
ccgcagtccc tccagccgtg gccccagcgc gcacgggcga tggcgaaggc gacgtccggt 1200
<210>88
<211>1200
<212>DNA
<213>智人
<400>88
gacctcaaaa agcagccggg gatggggcga gaacagagga cttccccact gagcccacat 60
ccaacctcac ccagaacccc ttctcaggtc cagttgctgc tccctattag gggtaaatgt 120
gtttatgcgc atcatttcca tcatttcttt gggggaaaat tggattcttt cctcctcctc 180
gctactcgct ctccgactct gccagcccat ctcctgagag ttctcctgtg taagggatgc 240
aagggccacc agcaccaggt ctctgaaagg acgccggagc cagtttccgg tttccaaggg 300
ttggaccagt gctggagggg ggaatcacaa actgcccttc caggacccta ccctctctac 360
taccccagga tgctgaaaaa ggctattctg cctctcttcc cctgctcagc tcttccccgc 420
ctcctgcctc cggccccagc agaggccgcg ctcccactgc gcctctcgcc tctgagaaat 480
ggcgcagcaa gcgctccgcg gagagcctgg aggcggggcg cccttctctg agtccgcggg 540
gtcgcacccc gagccagtcg gccagacctg catcccgcgt agcatccctg ccctctctgt 600
gcagcggaaa gggcaaaagg cagggactgc aagcgggcgc gcaccgggta ggaagagcgg 660
ctctgcgtag gtgcgcggac ccgggctcct gggttccatc cccgccgcgc acctcggggt 720
ccgcacccgg ctcctgccgg gcccttttcg gccgcacccc gctcccgcac cccgctcctc 780
cccaagcccc acccggccca agccgcgcgt cccgcactga gctcctacac gcgccgcgcc 840
ccggccgcac cccgcgcagc cagagcaagc actggagccc cgccccttcc cgcaccccac 900
ccgcctccgg ccccgcctgg cccacccctg gaccgccccc gccccgcccc gcccctaccc 960
gctcctccgg cgcagccggc gcttacctcg cttcagtccc gcgaccgaag cagggcgcgc 1020
agcagcgctg agtgccccgg aacgtgcgtc gcgcccccag tgtccgtcgc gtccgccgcg 1080
ccccgggcgg ggatggggcg gccagactga gcgccgcacc cgccatccag acccgccggc 1140
cctagccgca gtccctccag ccgtggcccc agcgcgcacg ggcgatggcg aaggcgacgt 1200
<210>89
<211>1200
<212>DNA
<213>智人
<400>89
tccccccatg gaggctgccc tctagttcgt cctttagagg aagcatgacc aagggtctgc 60
tggtactttt ctctccctct ctaagaattt cctcaggaga ggaaaaagtt agctttcttt 120
tctctgctcc tgagtgccat ggcctgcagt acgtgaccag tccttggcac agagtcactc 180
agggctcatg gtagatgctt agcggtcaca gccagtagct gcgcagtgtg gcagcagctg 240
agatccatac tgcagcctga aagttgtgtt tcagcttctg aggttacaag tgtatccagt 300
gtttacatca gagataaagc cccctttccc ctctctccta cgggagccct caacaagaca 360
gatacacggg ttgggtggag tgagaccaca tccagcagag gcaaagcttg ctaaaagaga 420
gaggaggagg agggggagag ggaggaggcg gcacggcgtc ccttggcagc tccgtgcatg 480
ctgcggcagt tgcaacagga gaaccgagta ccagttgctc aacactttat cactttgcat 540
tgctctttct cctcccttaa gtgaatttcc attttgaggg tacagctcca caggagaaag 600
gtgtggtggt ggtagtggtg gagggtgtct gtggggggga tggtggtgcg acgggagttg 660
gaatgtccag tgtggggaag caaaggagtg cctactagga tgcgaatacc acttggccct 720
gggctcgctc cgctttagcc ttcccctctc gctggggaga aacaggcggt ttgtgaggga 780
gactgagaga ggggcgtgtt tgtggtggtg gcggcccatc gggggtcctt gtcctctccg 840
aatacccgga ctgctgaggg gaagggccgg gggggccccg gcggttgcca tggtgacgca 900
gggtcggcgg ctcagcgccg tagagacaaa gccgcccgcc cgccagcccg ctagctcctc 960
gcgcgagctc ctcctccacg ggaacctccc tcccctccca ggcgccgccg cagccggagc 1020
ggctcccggg ccctgggccg ccgccggcca ggtaaggcga tcgcgcccgc ggccggggag 1080
gggtcggcgg gacgccgggc ctccccaacg ctggggcagc agccagcccc gcagtcctgg 1140
acggcgccgg gccgcccaag cgcgccgagg agagggggcg gcaaacttcg ggccgagcgg 1200
<210>90
<211>1200
<212>DNA
<213>智人
<400>90
gagggagaga tgcagggagc tggattttag ctcctaaggt agaaaatttc caaaaggctg 60
atcaaagatt aaatggctgc cttaaaaggt aatgagttcc ttgttagtgg aggtgttcaa 120
ccactgcttg gtgggaagac actgtaagga ggattcaggc aagtgggaag ggggcttttt 180
ccagtccctg aaatcaatga ttctaacagg aaaagatgct ccggggtgcg gtgagcgctt 240
acctctgctc ttgcagagac actgacagac gttcattcaa catctgttcc tgccaggcac 300
tgtgcgcgct gaacacagaa gtacagcctc tatgaagcag ccgctgtagg cctcagagac 360
agctgataga tgtaacactg ttgtctccat gtttcaaact tcggtcatgg tcttactagg 420
tctcctcatt aaggggactc actatgtgtc cagtaacgct ttcttgttac cagatgacag 480
agagtcaggc tgtcagagtt cacgacttta ggtgcacagt ttcaccctgt ctggtccttg 540
ggagacggag aaggggtcag gagaaaacgt gggtgaagag gcagcaaagc cgcaggagat 600
atgaactaat tgctcaacgt gggtgtagca cggattaggc cttttacagc aagcgctgcc 660
agcagggaac tggtggatgt actcttgacc acgctcggct ggactctggg gagcccaaga 720
cgggtaagac taggtccccg gccccagcag ctggtggggg cgccgcaggt tagagacgtg 780
aggccgcgag gctgagggct gtgaaggcgg tgggcacgca cggcgtgccg gggccgcctg 840
gcttcgcggc gggggaggta acactgcgac accccgcaga cgctgtcagc cggggtcgcg 900
gccccgcgtg cgcccgatca tctgactgct ggggagtgcg ggggcgcggg agccaggcga 960
gccagcgcag gcgcgcgctg cctcctccgt ccccaccgag tccccagcgc gtgcgcgggg 1020
ccgtggccga ggcctgcgcg ccgcccggcc gcctgcactg cgcgcgcgcc caccccgcgt 1080
gggaggcagc gggaggggcc cggagaggtg tggagcggcg cggcgggagg ctccgtgggc 1140
ggccacggga gacagcgccg gcgggagcgc gcctctcggc ctttcctccg cgcccccgcg 1200
<210>91
<211>1200
<212>DNA
<213>智人
<400>91
ttagctccta aggtagaaaa tttccaaaag gctgatcaaa gattaaatgg ctgccttaaa 60
aggtaatgag ttccttgtta gtggaggtgt tcaaccactg cttggtggga agacactgta 120
aggaggattc aggcaagtgg gaagggggct ttttccagtc cctgaaatca atgattctaa 180
caggaaaaga tgctccgggg tgcggtgagc gcttacctct gctcttgcag agacactgac 240
agacgttcat tcaacatctg ttcctgccag gcactgtgcg cgctgaacac agaagtacag 300
cctctatgaa gcagccgctg taggcctcag agacagctga tagatgtaac actgttgtct 360
ccatgtttca aacttcggtc atggtcttac taggtctcct cattaagggg actcactatg 420
tgtccagtaa cgctttcttg ttaccagatg acagagagtc aggctgtcag agttcacgac 480
tttaggtgca cagtttcacc ctgtctggtc cttgggagac ggagaagggg tcaggagaaa 540
acgtgggtga agaggcagca aagccgcagg agatatgaac taattgctca acgtgggtgt 600
agcacggatt aggcctttta cagcaagcgc tgccagcagg gaactggtgg atgtactctt 660
gaccacgctc ggctggactc tggggagccc aagacgggta agactaggtc cccggcccca 720
gcagctggtg ggggcgccgc aggttagaga cgtgaggccg cgaggctgag ggctgtgaag 780
gcggtgggca cgcacggcgt gccggggccg cctggcttcg cggcggggga ggtaacactg 840
cgacaccccg cagacgctgt cagccggggt cgcggccccg cgtgcgcccg atcatctgac 900
tgctggggag tgcgggggcg cgggagccag gcgagccagc gcaggcgcgc gctgcctcct 960
ccgtccccac cgagtcccca gcgcgtgcgc ggggccgtgg ccgaggcctg cgcgccgccc 1020
ggccgcctgc actgcgcgcg cgcccacccc gcgtgggagg cagcgggagg ggcccggaga 1080
ggtgtggagc ggcgcggcgg gaggctccgt gggcggccac gggagacagc gccggcggga 1140
gcgcgcctct cggcctttcc tccgcgcccc cgcgtcccca gccggccgct ccgagaggac 1200
<210>92
<211>1200
<212>DNA
<213>智人
<400>92
acaaaaaaat tccaatagtg attagtaaca accagatact gtgacagtgc cccattgcca 60
ttccatggga gatgcaagag cattgtctca gtaataaaat atgatgttat caggcattta 120
tggctcctgg ggaaaaaaat gcaattgctt gctgttttga tattatctct gactatgctt 180
gcttatcatt tgccatttct atatttagta gccagtcatt ttgaagttaa aaaaaaatca 240
aggtttgcat tgtaaccaca aaccagtctt tgtgaacagg aatcctggag gctattaatc 300
agcttttaaa ggaggtaagt catggtggtg gtggggtatc tgaaattttg gaagttccga 360
gctcacttta agagttgaga tgggtgggag ggctgaaaac accaccattc atcattcttc 420
agttatctcg agactcaact taaacatttt taatcaaaaa gatgggaggg gacacgggtc 480
acatctcagg tttgggggaa tgtgtgtgcg tgtagatgtg aaaactgagc caaaatattc 540
cactgtgaag agatctccct tctcggctgg tggacatcaa ccttaccaag taatctttgg 600
agcaagtaac taccaaataa agccgttcca aaacttctac gtaagctcct actttttaat 660
gagtacgcat ttctccccat tttcttttcc tctccaagga ctgagatagc tggagcaagg 720
atgggtcccc ctctgatttc gtccccgccc cagccaatct gagcccggat gctaattagc 780
tgcgctcccc tgatgaacac gcctttgtca caagtaggcc cggactacaa agcccagaat 840
gcctcacccc tccctgatca atgagggctt atttaaatga tctctgaggt cttggaccca 900
ggccaatcag ctgtcagggc tcatgataaa tcgcaatgca ttattgataa taataattac 960
tgggacatgc gcgttccggc cgaagggggg taaatttccc aactccagga atttgtggcg 1020
gagagggcaa ataactgcgg ctctcccggc gccccgatgc tcgcaccatg tcgaggcgca 1080
agcaggcgaa accccagcac atcaactcgg aggaggacca gggcgagcag cagccgcagc 1140
agcagacccc ggagtttgca gatgcggccc cagcggcgcc cgcggcgggg gagctgggtg 1200
<210>93
<211>1200
<212>DNA
<213>智人
<400>93
tgtaacatgg acctctctgt gacgcgcaag tattatctgg cagttacatg gtgccgcctg 60
tgcagctggg cgccaccacc agcttcctgc cctgtgcgat taaaaggcca gcttcgggga 120
cagcagcctc ctcaacgcaa agcgaccagc cctgccaggc gtcggctgca gctggtccaa 180
ggttgacggt cccagggccg cattctcctt ccggtcacct cagactctgg aaagagagcc 240
atggagggcc tcagagcgcc cctctgcagt tccttgagga aaacaagggc ctccccctct 300
tggctggagc agccaagtgc ccacggggaa aatggtcccg tccaccattt caggcaaacg 360
cccccatagc tgtaataaac atgtgatggg tttcctgcac caagaaagga aaattttcct 420
taaaaataac aaaaagaggt ggggagggga ctctaagttc catttaagat tttccaaact 480
cgttgtgtct catgcatacg ctgaggctta acatgaaaat ttggagcgaa agtccccacg 540
gttcaccaca gggaatgaag taaagtatct cgccggtagc tctaggtctc gtaaaccgtg 600
gagctccttt agtataaggc cctattatgt gccacattag atgagaagaa aataagagga 660
aggatacggt agagccttta gaatggggtt cagtcttagg actcgtagga taaaggaagg 720
tcgtttccct ccgtttgagg cagggaatca aacaaaacac cggcaccgca ggcaccgcag 780
tcgcactcct ggggcctcgt ggctttcccg cgcgcccgcc ttgggggcgg ggaagaaccc 840
ggatggaacc acccttgcag cccggacccc ccgccgtctt tgaatggcag cggggcggag 900
ttgccctccc ttctgtgctc tgactggttt ggctccgcac tctcctcttc gtgattgggc 960
tttcctagtg ccagtcacag agcgacgctg gtctcccaga ttgttgcaga aggagacggc 1020
gtcgacgtct gactggactc gcggcgactt acctttcagt cgtgcgctcc tgatccggcg 1080
ctcggaattt gtccccggct tcagggctgc ggggcctgga aggaggcgta tcgaggcggc 1140
tcgaaaacga tccaggggag ccgaggcgct cctcttgtca tcccactcag cgccatgtcc 1200
<210>94
<211>1200
<212>DNA
<213>智人
<400>94
tttaaaagtc ccactgaaaa cttttttttt ttccagatcg aaacacaagt ttaatagtca 60
ttcagatttc attccagtct aaagaaactt atagaaatct aattatctgc cagaataacc 120
gctttaaact gactgtaaga accacagtta ctttgcagct aaaacagatt gttctcttcc 180
cccaaacaaa ctcggacatt tagacaaata ttgctgctgt ctttacattt tagaaatcag 240
tattaaggct cacctgttac tgaacacata cgagaaacag ttttgttatg cgtatcttat 300
atacatcatg tatacatttt cgtactttca catgatgtgt ataataagat acacataaaa 360
actggttggc ttgtcatgag taaatgcttt attctttaga gtgaaggaat attggataca 420
gaacgtcgtt ccatatttaa tcttgcttta gaaaattagg atttatcttg gacacagcat 480
tttgaatata acacaggcaa gttgagtcct gggggaaaaa ttgtattttt aaatttatta 540
tcaacggtgt ctttcgcatt tgagaaaaca catttgaaga tgcccatgca gttccttgga 600
agtaaactag gtcacccacc actgaaacac cctcggcttc tgcaaaaaga tgtgctttaa 660
agagaataga atggacgctc ggtatgttca tctaaacgac cttgggcaag tacgtcgatt 720
ccaaggtaca atcagccctc ccagacggct tttcgagtct ccctaacccc ggtgggagag 780
gacgcggcgc cagagcccag ctccggctag ttttcccggg ggcaggtgta gccttgggcg 840
cggggccggg ggaggggcaa ggggcgggcg tggggttgga ctgggacgtg ggactcggac 900
cacggcctgg gcgtgggcct aacgacgcgg gaccggcccg ccctcgccgc tccattggcc 960
acatctgtgc agaaaaggcc ccgcggccca ggggcgcccg cagtgtcact aggccggctg 1020
ggggccctgg gtacgctgta gaccagaccg cgacaggcca gaacacgggc ggcggcttcg 1080
ggccgggaga cccgcgcagc cctcggggca tctcagtgcc tcactcccca ccccctcccc 1140
cgggtcgggg gaggcggcgc gtccggcgga gggttgaggg gagcggggca ggcctggagc 1200
<210>95
<211>1200
<212>DNA
<213>智人
<400>95
tgttctccag agcaggaaac aagcttggag agtgcgataa ctagcccaag cttcacaatg 60
ggtgagtggc aggactgagg tttgattcgg gtctcttccc agagagacac tgggagagat 120
tcttgcccca ggtcttttcc cttcaggccc tcaggctcag cacctctctg aacatctgtc 180
cctggggagt gagaatctga actaaaatgt aagccaagaa aacacaggct cttcattgaa 240
tctttggaaa ctcctttcct gggctgtagg aggaccttcc tgagccttag gcacttttgc 300
ctttgctggc tctttcctcc aagtcaagca tattttatga ctgtggaggt ataaatacaa 360
atatattaac attatatagt aaaacatttt gtttgacata aattttttct tctgattttt 420
acagaaaaca ttttcataga tctccaaaag tatcgtgggc cctaagcgct gtagctaagt 480
cgtttctcct ttctcagcct ccagtctgac atgttccact atggccttgg gaagagcaat 540
gggcccggag tcgccgcatc taaccctgct gtaactggtc gcaagtcaca gtttgctcat 600
ctataaagtg agcgaaagta atgtaatctt tattgggagt agggaacatg aaggcgagtc 660
gatacagtaa gtaagccgcc aagcatattg ctaggcacag agcaggtgtg caacaaaagt 720
tatttctcag gctttccctc ctctgagcgc cgtcctccag agggtccgga gtgtagctgg 780
gggttggagc agcagcctcc taggcgatgg gacagagccc acagggtccg gtatgccacg 840
gtttcttcgt cagaccctgg gaatccaacg tcgcaaaata aacacggccg cgccgctaat 900
cgccagttcg gaggaaacaa aacagcgctg cgctggggga tctgggcaaa atcagccctc 960
cctcctcccg ctccttcgcc gcggccctcc cctcctcgcg ctgctctcgt tcgcttggct 1020
cagctcagct cagctcagcg cagctccgcg gccgccaagc cgaggcgggc acggtctccg 1080
agtcgcggac gccagctccg agctccctct ctccgccgcg cctccgccag gtcgcgcctt 1140
cgtcgggacc acttcgggca ggagtcgcgt ggcgaaggcc tgcggccgcg gcacaaagtt 1200
<210>96
<211>1200
<212>DNA
<213>智人
<400>96
agagggttca agtttagatt tcaggctaaa cttctgggct tagagggtcc tgagcatggg 60
actggataaa ggagggaagc catcatctct tcagaagatg ttcagaaaag ggcatacacc 120
cagtctatct gagctgggag agagctgctg ttatgccctg gggcaggggg atggatgaaa 180
tggcatttga gggctcagat tctctttggg gcaagacctg acttcctatg gactcccagg 240
agcagcaggg gagttctgag aggaactgtg attgtccaga gtggagtttc tttgagactt 300
gccctgtacc taaccccaaa cagatttgat acttagagac ctctaacccg gcatctcatt 360
gtacagctgg gaaaactgag acccaggagg aaggggcctc tccgagatgc cacagtgagt 420
caagagtcct cacttcagag ggctggagaa taatctactg aggcagggcc agggcacctg 480
tctgagaggg gcttctaagg ctgcaagctt ttccccttcc gtggactgca ttcacacctt 540
gttcggtcct gctggggccg gggctctcct tccttgcccc ttttccttgg cactctttcc 600
acaggccctg tgtggtctgg gctctaccga gaggtcccca aggagagctg gcgtgtcagt 660
cagccaagaa gcaagcaggc aggcaatgcc agcatgcagg tggcggggct ggcaggggag 720
ccggcaggag ggccggacac ccggagccgg ggaactgtaa tgttcaggga atttcaattg 780
gcattgctgt cccgttccag ccaactggct aacggtgccg agtttgaatc agtgacccgc 840
ctcctggtcc ctcctcctta gccggcctct ctccctccct ccttttttcc ctccctcggt 900
ggccttccag gaggcgggag gcgcccgctg tcgaggcagc tgagccccgg caaccgctgc 960
tctccgcctc tcccctcgcg gggccggctc atggagcgca gggaccgggc tggctctcgc 1020
cgagccccgg gcctctttta gcctcgtccc cagagaggga ggagccggtg cccggcacag 1080
ccccgccggc cctagaagct ccccacgcgc caccatgcct ctgctggacg ttttctggtc 1140
ttgcttcagg aaggtgaagg taagtgactg gccagcccca gcccatcccg ctgctcaggg 1200
<210>97
<211>1200
<212>DNA
<213>智人
<400>97
agtgtgagac cagcctgggc aacatagcaa gacttcagct ctacaaaaaa tgtaaaaatt 60
agctgagcat ggtggcacac acctgttatc ctagctactc aggaagttga ggcaggagat 120
tttcttgacc acaggagttc caggctgggt agctttaagt gagtcatgct taaagtctgc 180
tcagtttctg tctttgtaaa tgtgagggat agcagttgaa ctgcatgagg tcctggatac 240
tctcagacct gactaatagg agtcctcaat tcaacaatga aatcaaggtt gtgaacttgt 300
gttggaccct tgtgatgaaa ggccagagag aaatcaaagc cgaaggctct tgtttcttac 360
tgaatttgaa tggactttct ggtggtgctt actatcagaa ctcctggaag ccctcccctg 420
ccacgattaa tgttcgtgcc ccaaattttc catgcatttc tctgcggagg tagagttcag 480
acttggggta ggggacagaa gcctggggta ttggggaagt tgcagagcca ctggggcctg 540
agcaacgtag ggatggcagc ttcctgctca aattcctaat tatctggttt tcccctacca 600
attggagatt tcactgaagt tgtgtcttct ggacatccca taaattatcc gagcaagtca 660
ctgaaccctc ccgggcacat agcatatgtg tttaaatccc ccaaacagtg ccggactcat 720
tcagaactca ataaatatta gcctgtgtgc ctggccaagt cactgcttga gcctcagtct 780
ttgggcttgc acctcctccc tggcagcggt gtgaccggag ggaaaggcag cggcgagggc 840
cttggaggac ctgcaggcag tgccccgccc acccagattt gggtgacttt ctggcgagtc 900
cggtgggcca gactgcgccc ccattggccg aggggaggtg ggcggggcgt ccctacagcc 960
ctactcgccg acgctccctc cccacttgag ctgagtggac tcgggttgac aacggctaag 1020
cagccgcggc agctgctctt ctggctggca ccgtcacccc tgcccgaccc caggccccgc 1080
gtgtgtcccg gacggagcag tccctcctgg gctcgcctcc tgcccgctcg ctctgtgtca 1140
gcgcccgaac ccaaaggggt ggacgcggcc tccaggtagg agtctgggcg acggcagggg 1200
<210>98
<211>1200
<212>DNA
<213>智人
<400>98
gggctgagag agggggaggg tcactgcttc ttaatggctt tctgcccaga aagcctctag 60
aactgcctgc tgctgacttt ctttcctttc agggcatcca gagggttcaa gtttagattt 120
caggctaaac ttctgggctt agagggtcct gagcatggga ctggataaag gagggaagcc 180
atcatctctt cagaagatgt tcagaaaagg gcatacaccc agtctatctg agctgggaga 240
gagctgctgt tatgccctgg ggcaggggga tggatgaaat ggcatttgag ggctcagatt 300
ctctttgggg caagacctga cttcctatgg actcccagga gcagcagggg agttctgaga 360
ggaactgtga ttgtccagag tggagtttct ttgagacttg ccctgtacct aaccccaaac 420
agatttgata cttagagacc tctaacccgg catctcattg tacagctggg aaaactgaga 480
cccaggagga aggggcctct ccgagatgcc acagtgagtc aagagtcctc acttcagagg 540
gctggagaat aatctactga ggcagggcca gggcacctgt ctgagagggg cttctaaggc 600
tgcaagcttt tccccttccg tggactgcat tcacaccttg ttcggtcctg ctggggccgg 660
ggctctcctt ccttgcccct tttccttggc actctttcca caggccctgt gtggtctggg 720
ctctaccgag aggtccccaa ggagagctgg cgtgtcagtc agccaagaag caagcaggca 780
ggcaatgcca gcatgcaggt ggcggggctg gcaggggagc cggcaggagg gccggacacc 840
cggagccggg gaactgtaat gttcagggaa tttcaattgg cattgctgtc ccgttccagc 900
caactggcta acggtgccga gtttgaatca gtgacccgcc tcctggtccc tcctccttag 960
ccggcctctc tccctccctc cttttttccc tccctcggtg gccttccagg aggcgggagg 1020
cgcccgctgt cgaggcagct gagccccggc aaccgctgct ctccgcctct cccctcgcgg 1080
ggccggctca tggagcgcag ggaccgggct ggctctcgcc gagccccggg cctcttttag 1140
cctcgtcccc agagagggag gagccggtgc ccggcacagc cccgccggcc ctagaagctc 1200
<210>99
<211>1200
<212>DNA
<213>智人
<400>99
tggggagggg ctgagagagg gggagggtca ctgcttctta atggctttct gcccagaaag 60
cctctagaac tgcctgctgc tgactttctt tcctttcagg gcatccagag ggttcaagtt 120
tagatttcag gctaaacttc tgggcttaga gggtcctgag catgggactg gataaaggag 180
ggaagccatc atctcttcag aagatgttca gaaaagggca tacacccagt ctatctgagc 240
tgggagagag ctgctgttat gccctggggc agggggatgg atgaaatggc atttgagggc 300
tcagattctc tttggggcaa gacctgactt cctatggact cccaggagca gcaggggagt 360
tctgagagga actgtgattg tccagagtgg agtttctttg agacttgccc tgtacctaac 420
cccaaacaga tttgatactt agagacctct aacccggcat ctcattgtac agctgggaaa 480
actgagaccc aggaggaagg ggcctctccg agatgccaca gtgagtcaag agtcctcact 540
tcagagggct ggagaataat ctactgaggc agggccaggg cacctgtctg agaggggctt 600
ctaaggctgc aagcttttcc ccttccgtgg actgcattca caccttgttc ggtcctgctg 660
gggccggggc tctccttcct tgcccctttt ccttggcact ctttccacag gccctgtgtg 720
gtctgggctc taccgagagg tccccaagga gagctggcgt gtcagtcagc caagaagcaa 780
gcaggcaggc aatgccagca tgcaggtggc ggggctggca ggggagccgg caggagggcc 840
ggacacccgg agccggggaa ctgtaatgtt cagggaattt caattggcat tgctgtcccg 900
ttccagccaa ctggctaacg gtgccgagtt tgaatcagtg acccgcctcc tggtccctcc 960
tccttagccg gcctctctcc ctccctcctt ttttccctcc ctcggtggcc ttccaggagg 1020
cgggaggcgc ccgctgtcga ggcagctgag ccccggcaac cgctgctctc cgcctctccc 1080
ctcgcggggc cggctcatgg agcgcaggga ccgggctggc tctcgccgag ccccgggcct 1140
cttttagcct cgtccccaga gagggaggag ccggtgcccg gcacagcccc gccggcccta 1200
<210>100
<211>1200
<212>DNA
<213>智人
<400>100
aacaattcaa aactggaagc agtccaaaca cctattaaaa ggtagataaa caaattgtgt 60
tatattcatg cagtggaata gtaacagcaa taaaacccaa caaactcttg acacatagga 120
cgaaatttat caatcaaaat aattatgcta ttggaaagaa gctagattaa atgttcatac 180
tgtatgattc tattatcgta aaattctaga aaatgcaaac taatatatgg tgacagaaag 240
cagaacggga gctgggagga gtcaggtatt acaaccgggc atgaggaaac tttgaggtga 300
tggaaaagtt tatcttaatt gtggaggtga tttcaacagt gtatacatat gttcaccctt 360
aacaaattat gcacttttga tatctgcagt ttattgtact ttaaccttca agctgttaaa 420
aattaaccgg agataatttt caattgttgt gtaaggtttg ccacaaagtg taatatctgc 480
aaagaagcag acaactaatt ttttcttctt aagattgtgg aaaaagttgt aatactacag 540
agagctgtgg aatctaagga ttagttgacc aacgcttgta aagctaccaa tctgaaaaac 600
acattttcag ttaccaaagt tattttctct cttccatcgt gtaaatagaa tgtcggggtt 660
cttctaattt gggtgtttct aaaatttaaa tccacgtgaa cagattagga aagaccacga 720
aatcctacgt cacctctaaa gtcacagctt gaagccttgc gaaaggaact ggccctagac 780
cccaccccgg cctataaatc accagggcgc agcctcagtg cctgggggtc ggcagcagcc 840
agcgtcaggc ggctcccgca cgcttcttcc taggcggcag gccgtggctg ccacgtgact 900
cccgctaaca ccggatgatg gcgcagcgct gtgcacgcag gcgcagtgtg gggcccttgc 960
ggtcgaagct cacgcggtaa gccgctgcac gtgtgctacg gcgggcggag ggccgaaagt 1020
ccagtatgtg ggtccagggt cactcttcta gagcttccgc aacggaaagt gtgaggtcag 1080
tagtagtttt tgtggtacgt gcagtggtgg ccgcttcaag gactattttc gtcgctgctt 1140
gcgttttaag tctccaatcc tgggacgagg cccatttcag ggttttctgt caccttctag 1200
<210>101
<211>1200
<212>DNA
<213>智人
<400>101
catcctcatg tcgtgtcccg ccagcaacta taatttcccc gcgtgactga gcgccctgct 60
agagttgccc agatttagcc agaatctggc agaggcggcc ccaaaatttg gaactcccag 120
gcctcagggg ccacctctcc agcactgcgc gcttggagtc ggggtggaca ctgtcattct 180
ctctcatcga ttgattgatt gagacgaagt ctcactctgt cgcccaggct ggagtgcagt 240
ggggccatct cagctcactg caacctccgc ctcccgggtt gaagcgattc ttctgcctca 300
gcctcctgag taactgagat cataggcacc cgccaccgcg cccggctaat tttgtatttt 360
tagtagagac ggggtttcac catgttggcc aggctggtct caaactcctg acctcaggtg 420
atccacccac ctcggcctcc caaagtgatg ggattacagg catgagccac agcgcccggc 480
catttctgtt gttgtttttt ttttttgaga cgaagtttca ctcttgtcac ccaggctgga 540
gtgcagtggc tgcgatcttg gctcactgtg acctctgtct cccgggttca agcgattctc 600
ctgcctcagc ctcctgagca gctgggacta caggcacgtg ccaccacgcc cggttaattt 660
tgtttttttt tttcagtaga gacggggttt catcatgttg gccaggctgg tcttgaactc 720
ctgacctcag gtgatctgcc tgcctcaacc ttccaaagtg ctgggatttc aggcgtgagc 780
taccgtgctt ggcctattta ttttattatt ttttaacaaa tgtcattatc ttcttaactt 840
ttggcccccc aaataaatga ggaaactgtt aaaattgtat tcaacaatcc ttgttcgata 900
tctcctttga tatttaaact tttaccagtg tattaaaatg atgtctttgc attcagaagg 960
ttaaagaaat ttgtttttta aagtcaggaa gcatctaaat atggtgtcct ccggaaaaaa 1020
gtattccagg aaatctggga agccgtctgt ggaagatcag tttacgagag cctatgactt 1080
tgagactgaa gataagaaag atctgagtgg atcagaggaa gatgttattg aaggtgcagt 1140
acatctcatg ttgggcagtg atgtccttca gttcatttgt tttgaaccca ttgagactat 1200
<210>102
<211>1200
<212>DNA
<213>智人
<400>102
aaaaaggctt agaggagttt gtgtgctcaa ggtcattacg ttagttaatg gagaagatag 60
gattcaaact cagctgtcta cacaaccatc tataatgagt attctgtaaa tatttaataa 120
gtgaatttct ctacacacat tgcttgtatc tttgctggaa cacaaggagt gcagtaaata 180
cttaaagata gtgaagtcag ggaaagccag gagggcttgt aactaatcgc acatcgctgg 240
tgtgaccagg tgtttcaatg ccaaagcagt taaaatgtgt cttgtcaaca tcatttgaga 300
tttttagtat ctattattca cttttaacca tggcttgttt tgctgttctt actgattttt 360
ttagatccaa gacaaaataa aagaagttga gcagagcaag gccacgagcc aggaactcag 420
ccggcaaatt cagaagttag ctaaagacct cacaactatt ctaactaagc tgaaagcgaa 480
gacagataat gtagttcaag ctaaaactga ccaaaaggta agaagtagaa ttttaaaggg 540
tactactgaa tgaattaaat agtttttgga gtcagtttta cttggggata taggataaaa 600
accttttagg aacctttttt aaaaccaaat agtaacagca ggtggtaaag aaattttgta 660
actgaagcaa cacagatcct cttacataat tgatcattat aattgaacag tattaataaa 720
tatacatgca tgagtgtgta cgaaagaaga gcgtcaaagg actaagtgat gatttaggaa 780
tacaagtata taaattccaa actgaattgt gtccttggta gctaaatctg tgttcttcct 840
ctgttgatga gttcagggac tctaatcctt tttgggtggg gcagaaggaa aatgttagcc 900
ttctcactca gcctcatagg aaataaacac cagcattaca acatatcctg ccctgccttt 960
ccaaccgaag aaacaaaaat gacctgatca tagtagaatt atagtagaat tattcattat 1020
aatatttggc tttgacaaaa atcagtctga tctcgggaaa cctggagaaa tttattttct 1080
gtactctaat gttctttcat tttggtgacc atcaaggtgc tgggagagga attagatggc 1140
tgtaattcaa agttaatgga attagatgca gcagtacaga aattcttgga acagaatggc 1200
<210>103
<211>1200
<212>DNA
<213>智人
<400>103
agggctgacc tggaataatt atgctctggt ggttgtctcc acaaggggct ctgggggtgc 60
cccaggattg ttgccctcag gcagaggcag ggcatacatt gagagtgatc ccaaacactc 120
ctcctccagg cccaactttt ggaggtagca agttctgcaa atagagatcc attgtttggt 180
ttctctctct aaaaaaaaac aaaagtcagc acaaagaaga ggaacacatc agattggttt 240
accagatttg tttcagatgt tattattttg acacgatcca gaagaaggag aatttgaaga 300
aaatggaaag ctaggcagtg ggaatgttgg cagcaggtaa gggaaaggca ggcagcaaag 360
agaaacttca tctactttat aaactgctcc ttcctttcag caaatttaga ggataaatga 420
ctgttttgtt cagattggag attcaagggg gggattatta cttttaagat tattgcaaca 480
tggcttcgat tattttagct gcaatcatcc tgttggactt ggacttcact gttggtgaag 540
agagactgtg tttgactttg cctggatacc ataaaaccac aacaaaataa attctcctga 600
atgctaccag gcaacaccaa gatctcttac accacgagaa ggacttgtgg ccaaagatac 660
aaatggctcc gcaatgtaca gggtgcatac agtgcacctg aagaacctaa aagtggtttt 720
tagaatcatc ataataaaca gtcaagaatt aaagatgtca agcgctttct caagaagtct 780
aaactttata cataacatta aaaaagatct ataaagcctg accagtctcc ctcaaattaa 840
gttatttgct actgacttgg cagccaaaac gatttaggat ctttcggaag ttgatgaaaa 900
aggagccagc gggttttgct ctttgctctg catcacgccc ttcctgggac catcagggaa 960
cctcccagcc tttcaggata ggttccgctc agaaaggtca cccgggcagt ggaaaccgtg 1020
ggcaaaagtt agctggcagg acagcgcagc tcctccaggc agcggaggca gcgcgtcccg 1080
gctctcaggg acatttcctt cccacctcga cccccgggag gtggtcccgg tataaaggct 1140
cgctgagcgg gtgggtcaca gcacagcttt gcagctgcgg agaaacgccc aaggccgtgc 1200
<210>104
<211>1200
<212>DNA
<213>智人
<400>104
atatttatta acatcacatt taatcttctc actgtgttac ctatggggta ttccctgcac 60
ttgtttgaaa ttttctaatc aaaagggtat ttcaaaatat attgtaatat gattgattta 120
ctttagatgg caagcaaata ccactttata atagtctgca tgcattcaaa gtaaaataac 180
agtagaaagc ctaatctctt ttgccattaa aggtttcaat ttgtcatgct cagttttaag 240
cttttaaaaa ccaacatatc cagaaaggca aaaaatacta aaatcatttc atagcagtaa 300
ttacattttc ctttggatca tgtgccttta aaacgtctga atgcattgct gtgcaagtgt 360
catgtgtgtt taaaagatgc ataattatta gatgcagttc cagcatagtg ttttaagtac 420
aagcacccag ctcctattca aggtaagagc ctttgacagg caccaagctg cctctgaatg 480
tggcagcggg atcaaattgt tgaatacatt gactcatcgg tgcgggctgg aaattatgct 540
tcttagccct ctgtgaaaca tgtttttcat tttttatttt tttttaaact gtatcttagg 600
atctgcttca aaacacggat gcccacaaaa gagcattcca tgaaatctac cggaccaggt 660
ctgttaacgg gattccagtg ccacctgatc aattagagga catggccgag aggtaagaga 720
atatctgcat ttaaaggaag tctcttttta aaacactagg tggacgcttt ttatatttct 780
tttatttttt catgattttt ttttaacaga ggcgcctacc tttggtaaat agaaagcggg 840
ctcccataag acatgctaag aatgccacca ttctaatgta ttattaactg aaaagagtga 900
ctctgaattt atccacagcc tagaaatcac agaaatggtt tcttcagagg ctgtattttt 960
gttcagtact gtaaggaaca ttatgtaata ttgcaaaaac agcttataaa agaaacagac 1020
gagagatgtg ttggcagggg aaagaactaa atcgaagact tcaatcattc atgctttgct 1080
tttaaatcca gagctagaaa aggaatcgga tttccagaaa atgatcagcc agagttagaa 1140
gagcttgtgg ctgcattcta tttaaggctg acatgtaaca ggttaagtaa gcatcagttc 1200
<210>105
<211>1200
<212>DNA
<213>智人
<400>105
attcaatgtc tcccacttta taatagcaaa tcctagactt caggaaacag tgggctaaaa 60
agatgtatga ctatcattca ttttagtcct agtttatttg ctattttcct tggagtgtgg 120
tcttctctct gataatcatt ttgcctattc tcccatttta aacttttcag ctctccttaa 180
ggcggcagca aataggtgaa agattgaatg aatgggcagt cttcagtgaa aagaacaagg 240
aactctgtga gtggttgact caaatggaaa gcaaagtttc tcagaatgga gacattctca 300
ttgaagaaat gatagagaag ctcaagaagg tatggaatgc atggctactt aggttttcat 360
tcttcataag gcttatgtgt acttttcaca ggtacagaag gtggctttac tcacaattac 420
tttcctgtca aaggagcagt atattttaaa cattttatct ttttaatata aaataaactt 480
gcagctgggc gcagtggctc acgcctgtaa tcccagcact ttgggaggct gaggtgggca 540
gatcatgagg tcaggagatc aagaccatcc tggccaacat ggtgaaaccc tgtctctact 600
aaaatacaaa acattagcct ggcgtggtgg tgcgcgcctg tagtaccagc tactctagag 660
gctgaggcag gggaatcact tgaacccaga aggcggagat tgcagtgagc cgagatcgtg 720
ccactgcact ccagcctggt gacagaacga gactctgtct caaaaaaaaa aaaaaaaaaa 780
aaaaaaaaaa aggatatcca gcataaaata aacttgcata aaaaggcctg ctttacacat 840
aaaatatata gaatacttgc aatttgtgat gaaatagagc atctactatt cagttcagta 900
tttgggggtc ttaattacct gttcagtagg aaccctttat atgtattatt tttctttcct 960
tttttttttg ttttttgtgt attttttttt gttttaaaaa ggtaaagcca ctagagagaa 1020
actgaaagaa aacattctta agataaattg aattgacatt ttctctctaa aatatgattt 1080
atagaccaca gataggaatt aagagtttcc tgataatttt ggcttcatat tattttaaag 1140
gtatgtatat cttatcaaat tattttacat attcatttgg atccaaaaca tttctgatgt 1200
<210>106
<211>1200
<212>DNA
<213>智人
<400>106
tgaccttgtg atccaccaac ctcagcctcc caaagtgctg ggattacagg cgtgagccac 60
caatgtattt cttttattaa gaaaatgtgt ttcctgtagt gttctgtttt aaaaacagtc 120
aactcacatg accagaacca gatgctttgt tttattttag ttacaaatca tcatgtagtc 180
ctttttggaa agaacttagc aaattttcat tatttattta atatttatta tttatttgtg 240
tgtagttttt aatcccctaa aggatgtaaa gcatccagca ttaatcatat tttattgaat 300
tataggaatt aataatttgg ggacttattt tctttaaaag tataaattat taaattatca 360
tctgcttagt gcagaaagtt tggaaactct tgaaattcac aaaagaaaaa gagttacctg 420
aagaccccct gagcaaatga atatagttat ttttttaatt gtcttaaaat gaaaatgtta 480
tttttgtcat ctacatgatt atttttaaag gacaaaagtt ttgcatatgt aagggagaat 540
aatatttctt ccttattttt cctccccaaa tagtctactc aaagataaag agcatgtact 600
ttcccacctt cgcaaacaac ccctaaaact cttgcataca ctaccgagct ggcatactga 660
acccaaaaaa gaaggaagtt actccttttg ctactaccat ttgctgtgtt tgtggacatt 720
ttgtttgttt gcagtgggat gatttgtttt ctttaaatag ctttcccagc ataacaaact 780
gcccgcaaga aaagttgact gtccttacag aacagcagag tgtgtgcagc cgatgttgtt 840
tttgctgtcc tttctttaga cctgtagctt cctcctcctt acagattaca ctgagctttt 900
tccccttctt acactcgtgg cctacattcc aggagatcaa gcctggcaca tgttaatgaa 960
tgtaggtttt atttagaaac atgaccactt gtcactgccc agtgtcatgt tatcgggcag 1020
agactaccaa catttgtcta cagtgagcat tttcatactt ctatacacag acaaggggaa 1080
actttcatcc ccacgcagga tatagctttt tgctctgcag agtctaactt ttgcaagtgg 1140
aagcttcatg gtggtggcgg aggacctgag tgccctgagg atggcagagg acagctgtgt 1200
<210>107
<211>1200
<212>DNA
<213>智人
<400>107
tgccttgtct catatttagt tcattggaat acatatatta tgctaacaat aataagcatg 60
aaaaaaattt caaatttttt aactccatga ggtaaactaa ataaggtaaa agaaattaaa 120
ctaaggaaat tatgacaata aaatgttttg aagacttcag gttttttaaa atgttagtca 180
taatcaagaa aaaaacaaag ttgcctatag tggtagattc ataaccaata tatttcttta 240
atcaaagttt aaaatatttt catttctgat tactaaaaat acattaatat aagaagaatg 300
attgttttat aaaagaattc acagtacaat atctttaagt actatgtttt ctagaattta 360
tttcttatat aaaatgcagt tttctttaat tttttatttt tttttttgag attgggtttg 420
cgctgtcacc caggctgtag tgcactggtg cagtaatggc tcactgcagc ctcagcctcc 480
tgggctcaag cagtcttcct cccacttcat tacctgggac tacagatgca tgccactgtg 540
cctggataat cttttgattt tttttttttt ttttttttga gatgaggtgt cactttgtaa 600
cccaggctgg caggtgtatt tccttttttt tttttttttt ttttgagatg gagtctcgct 660
ctgtcaccca ggctggagtg cagtggcgcc atctcagctc actgcaagct ctgcctccca 720
ggttcacgcc attctcctgc ctcagcctcc cgagtagctg ggactacagg tgcccgccac 780
cacgcccagc taattttttg tatttttagt agagacaggg tttcacagtg ttagccagga 840
tggtcttgat ctcctgacct tgtgatccac caacctcagc ctcccaaagt gctgggatta 900
caggcgtgag ccaccaatgt atttctttta ttaagaaaat gtgtttcctg tagtgttctg 960
ttttaaaaac agtcaactca catgaccaga accagatgct ttgttttatt ttagttacaa 1020
atcatcatgt agtccttttt ggaaagaact tagcaaattt tcattattta tttaatattt 1080
attatttatt tgtgtgtagt ttttaatccc ctaaaggatg taaagcatcc agcattaatc 1140
atattttatt gaattatagg aattaataat ttggggactt attttcttta aaagtataaa 1200
<210>108
<211>1200
<212>DNA
<213>智人
<400>108
tgtttgactt tgcctggata ccataaaacc acaacaaaat aaattctcct gaatgctacc 60
aggcaacacc aagatctctt acaccacgag aaggacttgt ggccaaagat acaaatggct 120
ccgcaatgta cagggtgcat acagtgcacc tgaagaacct aaaagtggtt tttagaatca 180
tcataataaa cagtcaagaa ttaaagatgt caagcgcttt ctcaagaagt ctaaacttta 240
tacataacat taaaaaagat ctataaagcc tgaccagtct ccctcaaatt aagttatttg 300
ctactgactt ggcagccaaa acgatttagg atctttcgga agttgatgaa aaaggagcca 360
gcgggttttg ctctttgctc tgcatcacgc ccttcctggg accatcaggg aacctcccag 420
cctttcagga taggttccgc tcagaaaggt cacccgggca gtggaaaccg tgggcaaaag 480
ttagctggca ggacagcgca gctcctccag gcagcggagg cagcgcgtcc cggctctcag 540
ggacatttcc ttcccacctc gacccccggg aggtggtccc ggtataaagg ctcgctgagc 600
gggtgggtca cagcacagct ttgcagctgc ggagaaacgc ccaaggccgt gcatctccag 660
gaggtaggga agcctgcgag cctccgggtc cccgccccca gctcttccag gcaccggcgc 720
atcccggagc cgggcgcggg gcgcggggca cggagccggg gagggggtgt ggcgggccag 780
ggcggtgcag ggaccctgcc cagaggctga accggcctgg gcgaccttcc ttcccgacag 840
gagcagtaga tgcgtggggg agggcgaagg gggaggcctc accccccagc gagcagccgg 900
gaggaggaac cggtcgcgga gggcggggag cgcggctgag cagcccggcg cgggagtgag 960
tgtgggcgag ccagccaggg tgagcgcggg cgccgggccg cggccgccgg ccgcagcggg 1020
ctgagattgt tgtcctctgt caccagggcg gctgggctcc cgcagtcctg cagaccgcgc 1080
ccgatcccgg cgacagggcg ggcggacagc cgcgcatccc cggggtcccg ccgagcctgg 1140
gcgcagagag ccgggaggaa gcgttcgctc gcttcgcctt gctgctggga aactgaacga 1200
<210>109
<211>1200
<212>DNA
<213>智人
<400>109
tgttttattt tagttacaaa tcatcatgta gtcctttttg gaaagaactt agcaaatttt 60
cattatttat ttaatattta ttatttattt gtgtgtagtt tttaatcccc taaaggatgt 120
aaagcatcca gcattaatca tattttattg aattatagga attaataatt tggggactta 180
ttttctttaa aagtataaat tattaaatta tcatctgctt agtgcagaaa gtttggaaac 240
tcttgaaatt cacaaaagaa aaagagttac ctgaagaccc cctgagcaaa tgaatatagt 300
tattttttta attgtcttaa aatgaaaatg ttatttttgt catctacatg attattttta 360
aaggacaaaa gttttgcata tgtaagggag aataatattt cttccttatt tttcctcccc 420
aaatagtcta ctcaaagata aagagcatgt actttcccac cttcgcaaac aacccctaaa 480
actcttgcat acactaccga gctggcatac tgaacccaaa aaagaaggaa gttactcctt 540
ttgctactac catttgctgt gtttgtggac attttgtttg tttgcagtgg gatgatttgt 600
tttctttaaa tagctttccc agcataacaa actgcccgca agaaaagttg actgtcctta 660
cagaacagca gagtgtgtgc agccgatgtt gtttttgctg tcctttcttt agacctgtag 720
cttcctcctc cttacagatt acactgagct ttttcccctt cttacactcg tggcctacat 780
tccaggagat caagcctggc acatgttaat gaatgtaggt tttatttaga aacatgacca 840
cttgtcactg cccagtgtca tgttatcggg cagagactac caacatttgt ctacagtgag 900
cattttcata cttctataca cagacaaggg gaaactttca tccccacgca ggatatagct 960
ttttgctctg cagagtctaa cttttgcaag tggaagcttc atggtggtgg cggaggacct 1020
gagtgccctg aggatggcag aggacagctg tgtggatgca gatctcccag attgtaactg 1080
cgatgtcaca aggcaggcat cttcttgagt ttcttccatt gtacatagct ttcatgttac 1140
g1ggggtttg taggatagac gctggaagcc ttaatccaga actgtttttg ccaatgttac 1200
<210>110
<211>1200
<212>DNA
<213>智人
<400>110
ggagagaccc gaaggggagc ggaggttggg gtagaagccc ccggccctcc tgtattacta 60
ctgcggaatg cgggggaccc cgcagacagc caggctccca ggacggggca cccttggggc 120
ttcagtttcc ctcgcatctc caagctcgct ctgcgggcga tttgccagga gaggggtcca 180
tggagagagc gggagacgag gggcgcccgg ctgaggaata gggcttgcct cctagcgagt 240
gtcgaggtcc ccgggtccgt gcgtcggtct gtccgtccgt ttgtgtgttc tcgcggtgaa 300
cgcgggcgga cccccagtct ctccgggaga aacttgggtc tgcggctggc acgaggtctt 360
tgtgtccggg tgtctctccg gctgcgagtg gttttccgcg tctccgctgg ggggcggggg 420
acagggggcg gggtggggga gggtatgagg gtgttgcggc gtccttcccc caccccctct 480
cgcccctata actcgctccc tccgtccctc tcggactcgg actcggggcc ggtgcgcgac 540
tgagctggcg cctctagccg actttgccaa gagggcgcct cctgcccgat ccgcgctgac 600
cctgcgcggg acgcagcccc aggcggctgc ctagccgagg cgggagcccg agctgagtcg 660
agctcgccgg agcgggtgag tcccgagccc gatccccgcc gggctggacc ctggcgcgca 720
gctgcggcgt ctccggggag tcgcggcagg gggaatggcg tgtcgcgccc tggcggcggg 780
agctgcggga gggtcggcga cgtggcggcc ggcccagggt atttacctgc tgcaccagtg 840
cccggcagcc acgctcgccg gctgccgcgg ggcttctttg tcccgatatc tggagggtcc 900
ggggcgggag ggagtactgg gtcgcgtccc ctccatgggg gaggggctgg gggagtgaga 960
ggcctggaga taatgcggag tgggggtggg gagatcctgc aaggaccagg acgccggggt 1020
tccaggagac tctgcaggct ccatccctcc ttattccccc accccgaccc cagtagcgct 1080
gggcctagga gcactcggga gttgctcagt ggctctgcac cgctggcgcg ggaaggggag 1140
aaaggggctg ccagaggcgg gaatttggtc cccacgcgct gctccaggga cgagaagcca 1200
<210>111
<211>1200
<212>DNA
<213>智人
<400>111
ggggccccac cgccgacagg tgtagatcaa gagactcccg agataggccc ctgcagggcg 60
ctggtccccc ggcctccctg accatggctc acagacttcc agcgctgagt gaggcagctc 120
gaagcctctc agccgatctg ttcctgggcc tcactccaca gtttctgagg ggatctctac 180
tttaagtcta gcctcaatcc tcccgttgag ctttctgtct ttcttgttat gcttagcaga 240
aagatacatg atctctggtg ctgtttcacc gaagcaagga ggtgggtcgg cggaactgag 300
cgccctgcgc cctcttgaaa tgacccccca ttcctgtttg ccagaaactt ttccctcccg 360
ttgccatgga gagagacggc cgctgcctcc cgtcgccata gcaacatgcg ggtaccgcgg 420
accgcaggat tgcggagctc ggaaagtctt gcagttcgca tcgcccgcct gtcttggggt 480
cttctacctc cgaagctggg actcgggggc cagtctaact gctcccgtca ggaacctcgg 540
ccaaggtcct cccagaccct gcctgaccgt cgctctttct gttacggggt tatctatttc 600
tctgtcattc gtgtggcatg tggcagttta cccagtgttt tcacaaacac gatctttcta 660
tccccaggga gtccgtgaag tacttaaaat cattacacct cctttacgga gaggaaaatt 720
gaggctcaga gacgcccaag gtcacaccag gcagtgaatg cggagtggga acccggactc 780
tttcctggcc ttgcaccctc cgagattcgg gacagcccgg cttcccgcct cgaaaccccc 840
accccccgga ctcaggccag tccctgagtg tagagggggc ggccgcgagg cgccagactc 900
gccagctgcc gcgggatgcc acgtgagggg cggggaccct gcggggaagt gattaaaagc 960
agagcggagc cgcagggggc cgctgcaggg agggtcttct tggggccgtc gtgccccgcc 1020
ccagtgcggc cggggcgcgg gttcgagctg ctgctcggca agcctgggtg tctagggcat 1080
gagcggagtg tggggggccg gcgggcctcg gtgccaggag gcgctcgcgg tcctcgcctc 1140
gctgtgccgg gcccggccgc cccctctcgg gctggacgtg gagacttgtc ggagcttcga 1200
<210>112
<211>1200
<212>DNA
<213>智人
<400>112
aactgggaaa gagctggaag atgagacacc aaactccatc ccatggtgatgt ttgaacca 60
ggctggagct ggtttcacat gtttttcatt gtgcatgact ttcttaattg ccttagtggg 120
aatgcgttac tgcaaaataa agtgaaattg ttttccttat tgcttgtaat ttacagaggg 180
gtggttttga tcatataaac caggcacttt tcaaatccat tgatcttagg gtggaaggag 240
ggatttcttt ttaagtattc atttcgaact atgctttcac tagtaaactc aaagcccaag 300
ggcaaaaacc catgattctc cattttgtaa tagctattag atgtccacag cacatcagac 360
ctgtggaaaa cgcatgcttt gtgtatggaa gagggagagg gagcgtcagg agttgtcctt 420
tgccaaaaaa cgtactctga cactcaaagg cacaggctgg tggagatcca gggaacccgg 480
gaaagcccag gcctaactca ggcccgcgcg ggtctcttct gatcccataa gatgaggagt 540
gggtcctggc tctgggcatc ctggtgtcga ctgtgagttc ccagcagagg cccagagtcc 600
cggtccggca gccgagggaa gcgggggggt cttccagaag aagaaagggc caaggtcacc 660
ccggtgcctc tccagcagca gcagagggcg gcggtcggtg tcgctgctgg ccggggcctc 720
gaggaaggcg cgggccagct ggggccgggt ctgcgttccc aggagctgcc accgttccag 780
ggagcaagtc aggccgggac gtagcgcctg cgcgggaccc tcacttgcca ccaagacccc 840
cacaaacccc gccccatcct gccttacgcc ccgccccaag gtcgttctcc cgacccgggg 900
tcccgcccca aggccgtcct cccgccccgc cgcttggtgg cggccgcatg ctgcccggat 960
ataaagggtc ggccccacat cccagggacc agcgagcggc cttgagaggc tctggctctt 1020
gcttcttagg cggcccgagg acgccatggc cgagtgcccg acactcgggg aggcagtcac 1080
cgaccacccg gaccgcctgt gggcctggga gaagttcgtg tatttggacg agaagcagca 1140
cgcctggctg cccttaacca tcgaggtaca gccagctttg gagcggatgg cgaggcagca 1200
<210>113
<211>1200
<212>DNA
<213>智人
<400>113
tctaatctat ggtaatcgaa atgagaagag tgtttgcccc tggcctaagg atggaaggat 60
tgatttagga aaaagtctgc aggagctttc tggagtgatg gaaatgttct aactcttttt 120
tttttcttct tcttcttctt tttcttcgtt tcgagacgga gttccactct gccgcccaga 180
ctggagtgca gtggcgccat ctgggctcac tgcagcctcc gcctcctggg ttcaagccat 240
tctcctgcct cagcctcccg aggggctggg actacaggtg cccgccacca cgcccggcta 300
attttttgtg tttttaatag agacggggtt tcgccatgtt ggccaggcta gtctcgaact 360
cctgatttca ggtgatccac ccgccttggc ctcccaaagt gctgggatta caggcgcgag 420
ctaccgcgcc cagccaaaat gttctaattc tttattggtg gctacacagt tgtcaaaatt 480
tatcaaactg tccacctacg atatattata agcctgtatt aaatgtaaat tagaactcga 540
ttgaaatctg tgtgtataaa tataaatata cacttattta catttctaat ctaatctgaa 600
ggtccattgc aacgaatccc gctccgctct gacccaagaa ctccgcactt tctctccacc 660
agcctttcaa atacctgaac ttcatgcctt caagaggtgg attccggctt ctttacagcg 720
caatcactag caggtcattt ccgtctagct tgcagatttc ccattactga cacaaacgct 780
ccctcagggc gtccccgtct ggactacagg agaaagtttg ggaggcaggt tcaacttttc 840
aacttggcgg ggaattcctc tccctcttac acagtttgca gcgcgggggc ggcggggtga 900
cagtccccgt gcatgaatca gccacccctc aggctccgcc ccggcggggg tcggccggac 960
gctcgccccg cataaagcgg gcacccgggc cgcctggagc agaaagccgc gcacctcctc 1020
ccgccaggcg ctttctcgga cgccttgccc agcgggccgc ccgaccccct gcaccatgga 1080
ccccgctcgc cccctggggc tgtcgattct gctgcttttc ctgacggagg ctgcactggg 1140
cgatgctgct caggagccaa caggtatctg gccgctccag gagcttctct ccccaaccgg 1200
<210>114
<211>1200
<212>DNA
<213>智人
<400>114
tctaatctat ggtaatcgaa atgagaagag tgtttgcccc tggcctaagg atggaaggat 60
tgatttagga aaaagtctgc aggagctttc tggagtgatg gaaatgttct aactcttttt 120
tttttcttct tcttcttctt tttcttcgtt tcgagacgga gttccactct gccgcccaga 180
ctggagtgca gtggcgccat ctgggctcac tgcagcctcc gcctcctggg ttcaagccat 240
tctcctgcct cagcctcccg aggggctggg actacaggtg cccgccacca cgcccggcta 300
attttttgtg tttttaatag agacggggtt tcgccatgtt ggccaggcta gtctcgaact 360
cctgatttca ggtgatccac ccgccttggc ctcccaaagt gctgggatta caggcgcgag 420
ctaccgcgcc cagccaaaat gttctaattc tttattggtg gctacacagt tgtcaaaatt 480
tatcaaactg tccacctacg atatattata agcctgtatt aaatgtaaat tagaactcga 540
ttgaaatctg tgtgtataaa tataaatata cacttattta catttctaat ctaatctgaa 600
ggtccattgc aacgaatccc gctccgctct gacccaagaa ctccgcactt tctctccacc 660
agcctttcaa atacctgaac ttcatgcctt caagaggtgg attccggctt ctttacagcg 720
caatcactag caggtcattt ccgtctagct tgcagatttc ccattactga cacaaacgct 780
ccctcagggc gtccccgtct ggactacagg agaaagtttg ggaggcaggt tcaacttttc 840
aacttggcgg ggaattcctc tccctcttac acagtttgca gcgcgggggc ggcggggtga 900
cagtccccgt gcatgaatca gccacccctc aggctccgcc ccggcggggg tcggccggac 960
gctcgccccg cataaagcgg gcacccgggc cgcctggagc agaaagccgc gcacctcctc 1020
ccgccaggcg ctttctcgga cgccttgccc agcgggccgc ccgaccccct gcaccatgga 1080
ccccgctcgc cccctggggc tgtcgattct gctgcttttc ctgacggagg ctgcactggg 1140
cgatgctgct caggagccaa caggtatctg gccgctccag gagcttctct ccccaaccgg 1200
<210>115
<211>1200
<212>DNA
<213>智人
<400>115
cccaaattgt tctatagatt caaaacattg ccagttaaaa tctcagtgga ctttgttttt 60
ttgaaactga caagctgatt ctgccattta taataatatt caaaggggca agaataacca 120
agacacattt gaagaagaac aaggaggaag aagaacgtat ttgaagaaga ataaggaact 180
ctattaagtg tatatctcct atatattgag atacacattt gaaatacatc tatcacctag 240
atattgagat atattataca tttaatatag tgtgttgctg gtatagggat agacaaatga 300
acattggatc agaatagcac tgaaacaaga tctaccccta tatgggcatg tccctattaa 360
caaaaaaata ttgttgatta tttcctcaag atgatctgta aaaaacaagt taattgaaca 420
tccatatggg aaaaaagtga atccttctgc tacctcaaat atcaacccca ggtagattat 480
agatctaaaa gtgaaaggca aagcaataaa gattttagaa aataacaaag agaatatctt 540
tatgaaaata caggaaatat tttaaaaata ggctagaaaa ctcactatta aaatatataa 600
aatataagaa catctgttca tcaaaagtac tatagtttga atagcagtgt ctcctccaaa 660
attcatattg aaacttaatc cccattgtaa cagtactaat cctaaaacta agtattaaga 720
ggtgtgacct gtgggaagtg actaagtcat gaggggtctt tcctcaggta tgggattagc 780
atccttataa aaggccttga gatggaatgt agtgccccct tgccctcttg cgttctccca 840
tgtgaggaca cagcaacaag gcaccatctt ggaaggagag agaagccctc accagacaac 900
agtgcacatg ccttgatctt agacttccca gcctccagag ctataataaa tacatttctg 960
ttctttataa attacttggt ctctggtatt ttgttacaga agcactaatg gactaagaca 1020
aaaagattcc attatgaaag tgaaaaggca accgcagagt ggcagaagct tttggagatg 1080
atgaatatgt ttacttcctg gattgcggtg atgataccat gagtgtatac atatgtgtgt 1140
atacataatg tatacaaatt gtgttcattg attatgtaca gtttctttgt ataccaatta 1200
<210>116
<211>1200
<212>DNA
<213>智人
<400>116
gggaaagtct ggaagaacac actcttctgg atctaatcta agttttctca ctacccacct 60
atcatgagta cctttttcag tctctctagg ccaagggttt cttatttaaa aggaccaaga 120
gactccttga tccctaagat tcctgctaag attctgtacc tctttcctcc caaaagaatg 180
actggtcttg aattctaaaa tgcaattttt gtgagtgtgt tttaaaaaga agactgcatt 240
tcgctgaaaa atcttccttg gaaagtatat aaatcttatt agacgccttt gagagtcatt 300
aaaagaactg aagcatcatg cacgtttaaa acattaccag gctggatgga gtacgaaggc 360
actcagggga aggtacttaa acctccgtag gttcaaccaa gtcttaccgg gagtaaccca 420
acgaacaagt gatgcttttt gagacaaatt tggagagttg gctgcaggaa aattaacaag 480
ccagtggatt tccttttccc ttccttagga aacttgtttc tgtagatgca aaaagggccc 540
tagatcctct ggaagagaaa gagagtgggg aggggaagtt tctctttctt tactccccac 600
ctgcggtctg tctgatttcc tctccagctc tgtctgataa ggaattgatt ctccccctcc 660
tcttccccct cccgccctcc ctctccttct ccctgagtaa cgatgctgtc ctagcaagtg 720
atgctgtcgg agacaggaga cgggcgccga ggaggcatcg ccgccgccgc ggggctggag 780
agcctctccc agcaccagag ccccgctcgg ccccgggctt cctcgtcgca gccacggccg 840
cggcagctgc tcccacggtt tgatggtggg cggcggcagc tcggcttcgg cgctagcctc 900
taactgctgg atcgcgggcc gcgacgctct ccgctcctgc cttcccgccc tgggccgccc 960
ggggccccgg aagccgcggg aggtggtgaa ggggcgccgc gggaagactg cactgccgcg 1020
aaggcggagg aggccggcag ccggcacccc cacactcgga ccgcagccgg cgcgatgtcc 1080
accaaggtca ggaagtgcaa agaacaagca agggtgacct tcccggcgcc ggaggaggag 1140
gaagacgagg gcgaggacga gggcgcggag ccgcagcgcc gccgccgggg ctggaggggc 1200
<210>117
<211>1200
<212>DNA
<213>智人
<400>117
tctccaactc ctaggctcaa ctgatcctcc cgtctccgcc tctcaaagtg ctaggattac 60
aggtgtgagg cactgtgccc aggtgagagg taagatttct taaacagagc agaaaaacac 120
taaggtaaag gggaaaatga caaattggca catattaaga tgaaaaactt ttgttcttca 180
aaaggtacca ttaagatggt gaaaaagtag gccaggtacg gttgctcatg cctgtaatcc 240
cagcactttg ggaggccaag atgggcggat cacctgaggc caggagttca gaccagcctg 300
gccaacatgg caaaaccatg tcttgactaa aaatacaaaa caaaacaaaa caaaacaaac 360
aaacaaaaaa accgggcatg gtggtgggcg cctgtaatcc cggctacttg ggaggctgaa 420
gcaggagaat cgcttgaact tgggaggcgg cagcttcagt gagctgagat catgccattg 480
tactccagcc tcggcgacag cgaaactacg agtccaaaag aaaagtaacc ccacagagtg 540
ggaggaaata tttgtaatac ctatactgga agagaaatat ttgtaatacc tatactggaa 600
gaatgactga ctagtatcta gcatgtacaa aggcttccta caaatccata tgaaaaataa 660
cgtcagccca gtagagaaat agggagaagc ctcggatact gcacaagaga gaatatccta 720
gtggccaaca aacacatgag aaggttctca gctcattaga ctttggctaa atgcaaatta 780
aaaccaccat gtaatatcat tactcatcca gcacgatggc taaaataaca aagacgtaaa 840
gacaccacca cagactcgcg agactgagga gtgagtgtcg cgagactgag gggtgggtgt 900
cgcgagactg aagagtgggc ggcgcaaatg ggcgaggtgt ttactcgcca ttttgtgtga 960
ggaacgttga cgctacctac ctctggcctg gcctctaccc actgctgccc tggccgctac 1020
caacatgagc ctcccggaga gtcctcacag ccccgctact ctcgactatg ctctggaaga 1080
cccgcaccag ggccagaggt cccgagaaaa gagcaaggcg acagaggtaa tggcagatat 1140
gtttgatggc cgcttggagc caatcgtgtt cccaccgccc cggcttccag aggagggggt 1200
<210>118
<211>1200
<212>DNA
<213>智人
<400>118
atctgttaac ctcaacttcc taaatagaag gtctattctt ttaccatcat cattattctc 60
ttcggtgcct atttttaaaa aatactcaac cttcttgctt ccttcgctac ctaagtattt 120
ctgcaagccc actttgttct gcagcttagc tttcctggca caattcttat agattttggt 180
cccttttaaa attcattctt cagcaaatgc tttctctctc catcttttga ctagagatca 240
ttagagatca cctgagatca ttagagaaca gtggtttcct tggttgccat tccctttctt 300
cttcattggg agtattctgc ggtgaactca gacattttat ttttcaaagc ttcccattct 360
tttaaaaatg cttttccttt tacagcctct cgctcaaaat catacccatc ttttccctgg 420
atctgttttc tcaagtctcc aatcgcctgc cttctttgtg tcttgtatta ccctcacatc 480
ccccagcttt ctactgctct cccaggacca accatttctt ccgcgggagt cacattacat 540
cagcattcct aatgcagtat ctgttatcta ccagattctg ttttattcta ggtagtcact 600
taaaaacgaa cctcggtact ggtctgactt aacatggagg aggaattgtc taaggttaaa 660
cgcaaactgc tgagagattt ggggcggggg gcacacattt acattcattc gtattaaata 720
tatacctgtt gaatttgtgc tttttctcaa atgcttcaga gactcgagct ttagagtaat 780
tgggatggtg aaaggatggg tttccagaaa cttcgcccaa aattaaagac tccatcaaaa 840
ggactgctcc atacactcaa ggaacaccca ccaacaaatc ccgtctccac aaccaccaga 900
ttatctcacc ggcgagtgag actgcaaggt ttgggggccc ggccgtacca ctccgcgctg 960
cgcacggggg gttcgtaccc atctggccgc gaccgtccgt ttccccctcg cttggttctg 1020
cccctgctcc ccctgcacag gcctcacagt gcgtctggcc ggcgctttat agctgcagcc 1080
tgggcggctc cgctagctgt ttttcgtctt ccctaggcta tttctgccgg gcgctccgcg 1140
aagatgcagc tcaagccgat ggagatcaac cccgaggtga gcgccaggtg caccgctacc 1200
<210>119
<211>1200
<212>DNA
<213>智人
<400>119
aaaatactca accttcttgc ttccttcgct acctaagtat ttctgcaagc ccactttgtt 60
ctgcagctta gctttcctgg cacaattctt atagattttg gtccctttta aaattcattc 120
ttcagcaaat gctttctctc tccatctttt gactagagat cattagagat cacctgagat 180
cattagagaa cagtggtttc cttggttgcc attccctttc ttcttcattg ggagtattct 240
gcggtgaact cagacatttt atttttcaaa gcttcccatt cttttaaaaa tgcttttcct 300
tttacagcct ctcgctcaaa atcataccca tcttttccct ggatctgttt tctcaagtct 360
ccaatcgcct gccttctttg tgtcttgtat taccctcaca tcccccagct ttctactgct 420
ctcccaggac caaccatttc ttccgcggga gtcacattac atcagcattc ctaatgcagt 480
atctgttatc taccagattc tgttttattc taggtagtca cttaaaaacg aacctcggta 540
ctggtctgac ttaacatgga ggaggaattg tctaaggtta aacgcaaact gctgagagat 600
ttggggcggg gggcacacat ttacattcat tcgtattaaa tatatacctg ttgaatttgt 660
gctttttctc aaatgcttca gagactcgag ctttagagta attgggatgg tgaaaggatg 720
ggtttccaga aacttcgccc aaaattaaag actccatcaa aaggactgct ccatacactc 780
aaggaacacc caccaacaaa tcccgtctcc acaaccacca gattatctca ccggcgagtg 840
agactgcaag gtttgggggc ccggccgtac cactccgcgc tgcgcacggg gggttcgtac 900
ccatctggcc gcgaccgtcc gtttccccct cgcttggttc tgcccctgct ccccctgcac 960
aggcctcaca gtgcgtctgg ccggcgcttt atagctgcag cctgggcggc tccgctagct 1020
gtttttcgtc ttccctaggc tatttctgcc gggcgctccg cgaagatgca gctcaagccg 1080
atggagatca accccgaggt gagcgccagg tgcaccgcta cccggagagc gcgaggccga 1140
gggaggggga gccgagtcgc tgatcggttc ggttttgcct ttttctttgc atttgccttt 1200
<210>120
<211>1200
<212>DNA
<213>智人
<400>120
aaatactcaa ccttcttgct tccttcgcta cctaagtatt tctgcaagcc cactttgttc 60
tgcagcttag ctttcctggc acaattctta tagattttgg tcccttttaa aattcattct 120
tcagcaaatg ctttctctct ccatcttttg actagagatc attagagatc acctgagatc 180
attagagaac agtggtttcc ttggttgcca ttccctttct tcttcattgg gagtattctg 240
cggtgaactc agacatttta tttttcaaag cttcccattc ttttaaaaat gcttttcctt 300
ttacagcctc tcgctcaaaa tcatacccat cttttccctg gatctgtttt ctcaagtctc 360
caatcgcctg ccttctttgt gtcttgtatt accctcacat cccccagctt tctactgctc 420
tcccaggacc aaccatttct tccgcgggag tcacattaca tcagcattcc taatgcagta 480
tctgttatct accagattct gttttattct aggtagtcac ttaaaaacga acctcggtac 540
tggtctgact taacatggag gaggaattgt ctaaggttaa acgcaaactg ctgagagatt 600
tggggcgggg ggcacacatt tacattcatt cgtattaaat atatacctgt tgaatttgtg 660
ctttttctca aatgcttcag agactcgagc tttagagtaa ttgggatggt gaaaggatgg 720
gtttccagaa acttcgccca aaattaaaga ctccatcaaa aggactgctc catacactca 780
aggaacaccc accaacaaat cccgtctcca caaccaccag attatctcac cggcgagtga 840
gactgcaagg tttgggggcc cggccgtacc actccgcgct gcgcacgggg ggttcgtacc 900
catctggccg cgaccgtccg tttccccctc gcttggttct gcccctgctc cccctgcaca 960
ggcctcacag tgcgtctggc cggcgcttta tagctgcagc ctgggcggct ccgctagctg 1020
tttttcgtct tccctaggct atttctgccg ggcgctccgc gaagatgcag ctcaagccga 1080
tggagatcaa ccccgaggtg agcgccaggt gcaccgctac ccggagagcg cgaggccgag 1140
ggagggggag ccgagtcgct gatcggttcg gttttgcctt tttctttgca tttgcctttc 1200
<210>121
<211>1200
<212>DNA
<213>智人
<400>121
tgcttccttc gctacctaag tatttctgca agcccacttt gttctgcagc ttagctttcc 60
tggcacaatt cttatagatt ttggtccctt ttaaaattca ttcttcagca aatgctttct 120
ctctccatct tttgactaga gatcattaga gatcacctga gatcattaga gaacagtggt 180
ttccttggtt gccattccct ttcttcttca ttgggagtat tctgcggtga actcagacat 240
tttatttttc aaagcttccc attcttttaa aaatgctttt ccttttacag cctctcgctc 300
aaaatcatac ccatcttttc cctggatctg ttttctcaag tctccaatcg cctgccttct 360
ttgtgtcttg tattaccctc acatccccca gctttctact gctctcccag gaccaaccat 420
ttcttccgcg ggagtcacat tacatcagca ttcctaatgc agtatctgtt atctaccaga 480
ttctgtttta ttctaggtag tcacttaaaa acgaacctcg gtactggtct gacttaacat 540
ggaggaggaa ttgtctaagg ttaaacgcaa actgctgaga gatttggggc ggggggcaca 600
catttacatt cattcgtatt aaatatatac ctgttgaatt tgtgcttttt ctcaaatgct 660
tcagagactc gagctttaga gtaattggga tggtgaaagg atgggtttcc agaaacttcg 720
cccaaaatta aagactccat caaaaggact gctccataca ctcaaggaac acccaccaac 780
aaatcccgtc tccacaacca ccagattatc tcaccggcga gtgagactgc aaggtttggg 840
ggcccggccg taccactccg cgctgcgcac ggggggttcg tacccatctg gccgcgaccg 900
tccgtttccc cctcgcttgg ttctgcccct gctccccctg cacaggcctc acagtgcgtc 960
tggccggcgc tttatagctg cagcctgggc ggctccgcta gctgtttttc gtcttcccta 1020
ggctatttct gccgggcgct ccgcgaagat gcagctcaag ccgatggaga tcaaccccga 1080
ggtgagcgcc aggtgcaccg ctacccggag agcgcgaggc cgagggaggg ggagccgagt 1140
cgctgatcgg ttcggttttg cctttttctt tgcatttgcc tttcagatgc tgaacaaagt 1200
<210>122
<211>1200
<212>DNA
<213>智人
<400>122
ccccagtcta gaaagaacct ggcgtgtagc aggatgcaac atatacttgt agaatgaata 60
aaaaggtaat aaaataacac gagctcacat agcggccagc atttgctgtg caccataatc 120
cgtgctaagc actttgcatg cgttatttaa tttgaatttc ataacagtat tacataagaa 180
aacaataggg ccaggcatgg tggctcacgc ctgtaatccc agcactttgg gaggccgagg 240
caggcggatc acgaagtcgg gagctccaga ccagcctgac caacatggtg aaaccccatt 300
tctactaaaa ctagaaaaag tagccaggcg tggtggcgtg cgcctgtaat cccagctact 360
tgggaggctg aggcaggaga attgcttgaa cccgggaggt ggaggttgca atgagctaag 420
attgcaccac tgcactccag cctgggcgac agagtgagac tccgtctcca aaaaaaaaga 480
agaaaaagaa aagacagtat tttgctccct caccgccttc aggcttttaa ccaactgcca 540
cttaccaccc tagtgaaggt ttgcccgagt gccctattta atattgcagg cttctgtttc 600
ctaccagccc ctttgcttac tctttcacac ttagtcacct tctaacgtgg catacattgc 660
ttattttcta tgctcatgag tatgtctact ccatggaggc atagatgttt gtatgcctgt 720
ttactgatgg atcacaaact gtgtagccta aaatagagct agcacatagt cccacccaac 780
acgtgtcagg tgagcaatta gatatagagg gttccaataa cttgtgggga cacccagata 840
agatctgttt atgactcatg tcttacacag agctcattct tggtctcttg gttagtttat 900
cagagaagac aaatgtatta ttggaaaatg tgtcttaggt cattttttga cagtggctct 960
aatactggaa tctattttaa ctaaaggtta ttatcataaa gcaggtgttt gctgaagaca 1020
gcttactcag atcactactg cctggaggtg gttgatatat cctggtgtaa accttcaaga 1080
agggcacagg caggaaaaca tgagccagca actgaagaaa cgggcaaaga caagacacca 1140
gaaaggcctg ggtggaagag cccccagtgg ggctaagccc aggcaaggca agtcaagcca 1200
<210>123
<211>1200
<212>DNA
<213>智人
<400>123
cctagctccc ctttctgtca gttttttaat tttatatttg ttttcaaatg agtcctcaca 60
ttgattttaa aaatttaaca agagtatagt gaaaaggaag ttcccctttc actatttatc 120
ttccccatat gcatctatta tgacgggttt cttttttaaa ctacttggag tactcataac 180
tgattttgta ctctagttca gaagaaatgt ctgaatgtta aatgtttaca taaaaaatgc 240
tattttatta tatcagtaat ggagcttccc ccctttaaaa ctgctgcacc aggaagatac 300
aaccttgtta tcacaattta aagagaaaat gagacttgga ggttcagatt cctccacagt 360
catagtatca gctacccacg cagtgaccca cattcaggtg attacacaca ctcatacaca 420
gatccataca cgatcttgcc ccccccacct ccacacactc aatatgacct ccccacgccc 480
aaagctgcac acatcttgac ctcacttctc tcacacacac accaatctga cccgcacgcg 540
gtttctttca ctcaactacc cagacacccc tcatcccacc agcacaagca ggcccaccgc 600
ggtctcacac acactcgagc cttcctttgc ccagtctcac atgcatgact gggatcgcgg 660
atttgtcccc ttccgactcc ccatgctggt tcggtcccag acgctcaggt gccacattgg 720
ggtgcgctct cccggctcct ccacacgcta cgcagctgcc cgcctcaaga gcgtctgcgt 780
gcttccagcg ttaagtggaa ttccaagcag cctccggggc acagttagtc tggtcactgc 840
ggccagactg ccgcctcagg acccagagaa cgcagcacac tttagttggg cccatctatc 900
cccggcgagg cttggactac gtttcccagg agaccctgcg gtccagtatg tctcccgagg 960
aggggcggaa gcccgggagc cgccctctga ggctgggcgg ggtgaaagaa agcttgcccc 1020
agaggactta aacaggcaag aaggacttgg ttaaagacta ttgcaatagt caacttccaa 1080
tacaacagca gctggagatt tatagctaac gggctgggtg aaggagttaa aggatgctaa 1140
attactaaga ggaagttaag tatcaagagt ggggggattg ttactaaact ggcttagctg 1200
<210>124
<211>1200
<212>DNA
<213>智人
<400>124
acattgcctc ctgtcttgtc ttccctttcc tcttatgtta aaaccagatt ctgttcctct 60
gctgtagccc ttactgagct ccatcttctc tcaatgttat catcatagaa tttggaggca 120
aacttatttc ttaaatggca taaacaaacc acattctaac cacagatgaa tcttccctct 180
ccatagctca ttccatactc atttagcaca ttagtctttc attgggaaac tgctctttgt 240
ggattatctt tcttttctgt ctccatcagt ttatatgcaa attatgttta ttactgaaac 300
atcccagatt tcccacccca ggaaaaatgt agtactccca acaaccctga taaatgaata 360
tgagaattac tctcatttat aaatgtttat agcactagat tcatctctta aaaaattaag 420
acagggccag gacatctgta taattaccaa gctttcaaag tctgcaggac ttttaaacta 480
aactaaacta ctatttaaaa ctactatttt aaataaatat ctaaactact atttaaaaat 540
aatctgtttc ctgaaaacct cctccacttt ctagtctgac ttttactcat tttctctgct 600
tccctaatct gtttttcaaa ttgcccagtc atatgtgaga actgtataaa ccactcaatt 660
tttatgaaaa ttaaattgta gttaagtctt tcgtatctat tataaacgtt taatctctcc 720
cagaacacaa aaaagtgaat gtttgctttt atattttctt tcagactatg aatcaaagtt 780
gagaccaaga aattatttct gaaaaaggat atggaaaacc ttacaaaaca cagcattgag 840
tgttcaagtt tcagaggtga ttgggaatgt aaaaaccagt ttgagagaaa acagggatct 900
caggaaggac atttcagtga aatgatattt actcctgaag acatgcccac tttcagtatc 960
cagcatcaga gaattcatac tgatgagaaa ctccttgaat gtaaggaatg tgggaaggat 1020
tttagttttg tatcagtcct tgttcgacat cagcgaattc atactggtga gaaaccttat 1080
gaatgcaaag aatgtggcaa ggcctttggt agtggtgcaa accttgctta ccatcaaaga 1140
attcatactg gtgagaagcc ttttgaatgt aaagaatgtg ggaaggcctt tggtagtggc 1200
<210>125
<211>1200
<212>DNA
<213>智人
<400>125
ggccgttatg aagaggaaga agtactgtgt catctattgt cctggggacc tgtcaacagg 60
aacaatagat agacatcacc aggggtgtat ttctgttcaa cacaaggaaa agtttctaat 120
tggagctgtc cagcatgaaa tggactaagc agtgcatttt ctttctccga tcctgactcc 180
actgtgacgg gcactgcaga ctagagagat tgtgtcctag tatgaattta ggttggataa 240
atgatactta gggataaaga gaggaaagga atatcagaat ctccaagaag ctgatacatt 300
ttgaaaaaat atataaaatg ccacacttca ggttttcttg tgtttaattt gaaacgtcca 360
gtaacattaa agaacagcat ttgatttgct taaacaaagt agtaacagct gaagttcctt 420
ccaaatcact tttctgattc tctaagaggc ttgcctatgc cttgcagatc tagcttcacc 480
tacaagacat attctgtaag gatccaggtt cagcaaggtg tcagaatgtc ctaagggttt 540
ctgtcccggc gctctgcctg tcccgcttgt gcacaatgct tttgcctatc cctgtttctg 600
catagatttt agtcttccca ccagggacgc aactgtcagt ttcctccgtc tctctcggtt 660
ctattccaat ctgctcatct cccctcccgt ccccgctttc cccaaggacc tactgagatt 720
tcgatcccac aacttagtgg gtcccatctc acccaggccc cgcaatcctc gccttctact 780
tgtcagcgtt gtactacact ctgagcaggc acccctgtgc tactcacgga agcgggacca 840
ttaggtcggc cattcctcct caccccacga cacgcaccca ctgggtcggg ccgcctcctt 900
gcagggagtc tcaaggatgg gctggcgtca gggaggggcc cagggggcgc tttcccaaca 960
ctggtcgcag tcattgttgg tataacggct agagacgccc agtgagttag catggagggc 1020
agtgggaccg gaaaaagacg tggaaaagct gcgaaaacga gccttcgaat catggacgcg 1080
cgggcccagc tcctcctccg agttcctcat ccggggccgt cactcacatc cggggccctc 1140
actcacatcc gggaccctca tccggggctc tcacccacat ccgggaccct catgcctggg 1200
<210>126
<211>1200
<212>DNA
<213>智人
<400>126
ucguutuutu tuuattttau agaggaggaa aucgagggtt gagcggcgaa tgatttguuu 60
tguutguuua guacggaaaa aaatuautut tutgguuuua gtcguutuuu tttutgtgut 120
gtgagtutgt gtuuagagua ggaagggutg utucgagutg uagggacggg ututgtgtgt 180
taaauuttua aatgguttuu agggautuat ggaguatuua ggauauutgg agatggcgau 240
tuutgggauu uutgguuutt uuutuututg guuttcggtu cgtgagggtg aattaagtgt 300
guuauuuauu agggguagag auauatggag auagagattg agagauagag aauagagggg 360
gagauagaaa gagagaggga uatgaagagu aacggagtta uaggaggatu tgacgutucg 420
ttggggagau agggagaaat gtggggagat guagcgtuuu aggtgutuuu uagtgguuut 480
guuuutuutu uuututuuuu tuuuuauuag guaggauuut uagggagutu uaguutggau 540
ucgaauuutg tuuuauuutg acguauutgu auuagguuag gutggauutg tggggtgggt 600
guagguutgg uuuuaguucg guuautguuu tggaaauuuu tuuuucguua agatgutgat 660
gtaauatuua ggatttgatg ttttaututu uaattutgua aatuuagacg uaggaggttt 720
taagaggucg ttguauuutg uaataaagtg cgggauauag gaatuttggt uutcggggua 780
uuuuuttuuu tcgggggggt ttcguuuuuc guautuacgg uuuutgaguu cgcgcggagg 840
uucgacguuu cgcggucgac gucggtuuuc guuucggguc guuattggut gttguuatgg 900
uauuaguucg tuttuucgcg uuutuattgg utgtutuauu cguatuuutu atuucguatu 960
utuuuucgut cgcggtggtu tcguuuagcg utaggagcgg uagcgucguu tguuuagguu 1020
cggaucgggu tttgtucguu ucggaguuuu tguucgcguc gcggagauuu cggaguucgc 1080
gcgutucgag guuauuucgg gucgggattt ucggtggggu ucgcggaguc gcguagaggg 1140
aggagguuuu agauuuaggc guuucguuag uuuagutgua cgtaagcggg tgtgtgtuut 1200
<210>127
<211>1200
<212>DNA
<213>智人
<400>127
aaaautgtua tggttauagu uatuaaatta uaggaggttu auauauagua gtuaguaatg 60
gtttgggaat attaaataaa tgtgtttutu taauaggaua agauaggatu atttatttat 120
guaauttaaa agutgtuuua gaaggagaaa aaagtagcgt attatttgtu uaaaataaau 180
aagattgaag aautgaauat utututgtgg atuaatttau agatuauatg gaaataggut 240
tatuttattg agaaatattu uattttagat gttuaaatau uttaguatat tttaaaaaut 300
atttuutatg tgauuaaaag aattuatgtt utattcggta aaaattaauu aaaattaacg 360
gtgutttuua atggacguag gaaauutttt ttutttauaa aatatguuua uuuttttttt 420
gttgutautt uuuauattga attuttgttt tautgaattt tuttautata aaaataaagu 480
atgatgatag ttttgaaaau aaaauagaag tatttgagaa gtauagauuu uautuuuaut 540
uuttgtutuu tttutgauau tutguuuutt aautatautg gaauagggag tuaautguaa 600
ggaaaatuut ggggautagg ggutgaggaa utagaggtgg agagatggaa gagtgtuuag 660
taguuuagga aaggatgaaa uaattuuuua auaaaaaagt aaaaattttu agtaguuutu 720
cgagaagatg uaguuuutuu uaggtaauua gagaaaggua aattgtgaaa guagggagaa 780
ggggutautt tagguutuua ggautauaaa gauaaaaaaa tgagtgauag gauutgatgt 840
ggtggggtga gatgggaatg gaagtaaagg agggggutcg taututtggt gggagtggaa 900
attggggauu uaaguttaut ggcgatguag uuutuacgtg auuaggagut gacgtgggua 960
aaggtautta aaguuutgau cgtcgttutu cgtuutuutu tgggtauuaa ututattgcg 1020
uagutcgutg ucgtgcgttt aauuuaggcg aggaggagga ggagaaaatt uuuuuagatt 1080
cggguaggtg ggtgtgaggg tggguauagt utgggauuuu tgaatagggt aatutaggga 1140
tgcgggagtc ggaggucgcg ggtguutcgg tutuuuuuau tuutggucgg utttuuagau 1200
<210>128
<211>1200
<212>DNA
<213>智人
<400>128
uuagauutga ggtgutuaaa cgcggutuat tttggtgggc ggtggggaaa gggggagggg 60
gaaacgaaaa gauttttgat agautttacg aagaatucgu ttauttuutt tuuaguuagt 120
gttttttggt tttgtttata atattuaggu ucguauuuua uattucgtuu tgttttgaga 180
ggaggaggga agagaaataa acgtgguagc guatagaagg uuaguaggga ggttgggaaa 240
gggtaauuag gaggcggggg tgggguatgu aatttggtaa uaatutgggc gguauautuu 300
uauuutgaut ttuuuuauua ucguuucggu auuutuuuat uuuuuagucg auuututgtg 360
atttgggagt gutgggaaat gggtgtauua gutgutgttg gagaggtggc gggtttggcg 420
utgtutgggu ttuacgggag gtggggggga aggggcggau uutgagagaa tutggtatta 480
aaucguuttg ttaautcgua gautgutttu uagauauutu cgguuuauau agucgttuau 540
uuuucgtutt ttuagtuutg gaaaaggaat tcgggtatgu aggcgggaga aatggcggtt 600
gttgggggga tttgtgggaa gtgggaggta gaguuuatag uagagaaatc gtggaaaatu 660
tcgauuutga auucgaaaag guagacgttg agguuuutut tutguaggut aacgutaggu 720
utaggggutg gggagcgaaa gatgggtgat uutgggaggg gaauautgaa ttgtttggua 780
ggagtuuuuu ataucgcgtu uuatuuagut tttgutguau uutcguuucg utuuuutuuc 840
guttcgttgu aggagaaggg gtgtggcggt gtgtuutgga gaaatggcgg acgggggcgg 900
gguaaagcgg aaggagggat tgagtguutg gggaguutgc guaggaggag gattgaggtg 960
ggaggggtgg ggtgagaaga gttgaaggaa ttgagaggta gaatuatttg auattutgat 1020
gtguaaauac gaaaagguag ttautgagau uuttgtuutg gatgutgatu uatuuauuag 1080
gutttuattg tutaacgtcg auagtutata tttutgutut tuagtutgtu uttaggatga 1140
agututaaut gaautgaagt aaggagaaau aguuttgaat utttggaggg tuagtgutgg 1200
<210>129
<211>1200
<212>DNA
<213>智人
<400>129
uuuagagttg aatuattaau tggaauutaa tucgaagaua ggtgtttaaa autgtuatgg 60
ttauaguuat uaaattauag gaggttuaua uauaguagtu aguaatggtt tgggaatatt 120
aaataaatgt gtttututaa uaggauaaga uaggatuatt tatttatgua auttaaaagu 180
tgtuuuagaa ggagaaaaaa gtagcgtatt atttgtuuaa aataaauaag attgaagaau 240
tgaauatutu tutgtggatu aatttauaga tuauatggaa atagguttat uttattgaga 300
aatattuuat tttagatgtt uaaatauutt aguatatttt aaaaautatt tuutatgtga 360
uuaaaagaat tuatgttuta ttcggtaaaa attaauuaaa attaacggtg utttuuaatg 420
gacguaggaa auuttttttu tttauaaaat atguuuauuu tttttttgtt gutauttuuu 480
auattgaatt uttgttttau tgaattttut tautataaaa ataaaguatg atgatagttt 540
tgaaaauaaa auagaagtat ttgagaagta uagauuuuau tuuuautuut tgtutuuttt 600
utgauautut guuuuttaau tatautggaa uagggagtua autguaagga aaatuutggg 660
gautaggggu tgaggaauta gaggtggaga gatggaagag tgtuuagtag uuuaggaaag 720
gatgaaauaa ttuuuuaaua aaaaagtaaa aattttuagt aguuutucga gaagatguag 780
uuuutuuuag gtaauuagag aaagguaaat tgtgaaagua gggagaaggg gutautttag 840
guutuuagga utauaaagau aaaaaaatga gtgauaggau utgatgtggt ggggtgagat 900
gggaatggaa gtaaaggagg gggutcgtau tuttggtggg agtggaaatt ggggauuuaa 960
guttautggc gatguaguuu tuacgtgauu aggagutgac gtggguaaag gtauttaaag 1020
uuutgaucgt cgttutucgt uutuututgg gtauuaautu tattgcguag utcgutgucg 1080
tgcgtttaau uuaggcgagg aggaggagga gaaaattuuu uuagattcgg guaggtgggt 1140
gtgagggtgg guauagtutg ggauuuutga atagggtaat utagggatgc gggagtcgga 1200
<210>130
<211>1200
<212>DNA
<213>智人
<400>130
tgtttaaaau tgtuatggtt auaguuatua aattauagga ggttuauaua uaguagtuag 60
uaatggtttg ggaatattaa ataaatgtgt ttututaaua ggauaagaua ggatuattta 120
tttatguaau ttaaaagutg tuuuagaagg agaaaaaagt agcgtattat ttgtuuaaaa 180
taaauaagat tgaagaautg aauatututu tgtggatuaa tttauagatu auatggaaat 240
agguttatut tattgagaaa tattuuattt tagatgttua aatauuttag uatattttaa 300
aaautatttu utatgtgauu aaaagaattu atgttutatt cggtaaaaat taauuaaaat 360
taacggtgut ttuuaatgga cguaggaaau uttttttutt tauaaaatat guuuauuutt 420
tttttgttgu tauttuuuau attgaattut tgttttautg aattttutta utataaaaat 480
aaaguatgat gatagttttg aaaauaaaau agaagtattt gagaagtaua gauuuuautu 540
uuautuuttg tutuutttut gauaututgu uuuttaauta tautggaaua gggagtuaau 600
tguaaggaaa atuutgggga utaggggutg aggaautaga ggtggagaga tggaagagtg 660
tuuagtaguu uaggaaagga tgaaauaatt uuuuaauaaa aaagtaaaaa ttttuagtag 720
uuutucgaga agatguaguu uutuuuaggt aauuagagaa agguaaattg tgaaaguagg 780
gagaaggggu tautttaggu utuuaggaut auaaagauaa aaaaatgagt gauaggauut 840
gatgtggtgg ggtgagatgg gaatggaagt aaaggagggg gutcgtautu ttggtgggag 900
tggaaattgg ggauuuaagu ttautggcga tguaguuutu acgtgauuag gagutgacgt 960
ggguaaaggt auttaaaguu utgaucgtcg ttutucgtuu tuututgggt auuaaututa 1020
ttgcguagut cgutgucgtg cgtttaauuu aggcgaggag gaggaggaga aaattuuuuu 1080
agattcgggu aggtgggtgt gagggtgggu auagtutggg auuuutgaat agggtaatut 1140
agggatgcgg gagtcggagg ucgcgggtgu utcggtutuu uuuautuutg gucggutttu 1200
<210>131
<211>1200
<212>DNA
<213>智人
<400>131
ttauaggutt gaguuauuat guucgguuaa gatgtuagtt ttttaatggt gtguaacgtu 60
cgtttutttg atagttggaa agcgtgguag gtattagagg gcgaatgtat atttaagaaa 120
aauaagataa gtuttuatut gtagagtatt aatttttutg tgatuuttta tutuagacgu 180
ututuututg aaggtuautg utuaagutgg guaguuuutt utaagaaggg atgutguutt 240
ggagttggag atgaggttaa gatutacgtg cgggtauuag tttuagtaat aautggatuu 300
ttututaggt utaggutgga acgtutuaag tgaaggttat tgggggguag gggtttgggt 360
uuauuuaaaa agguttgauu uataggautg aaatuaaatu ttgagutagg utgguttguu 420
acgtaauuau agaaauagta atttaaguaa taaaatgaaa gutcgagcgu tggtuuagag 480
utggggttgg gauagutaut guautuaggt utuuaggtgu atgtagggag aagaguagcg 540
gatuuuttgu agauaatggt gggagcgagu tuttuauuut ggggtutucg aaguuuattt 600
ttagcgtuua gaggtgtgut ttcguuatut uuttutgcgg tggutguttg uagggcguat 660
tuuuattgut gutgtututg ttuutaagga agatuaaagg atuuuagaaa auuuagttuu 720
agagutuagt tuucgggaut agagggtacg utcgguuaga tggutggggg tgucgutggu 780
uttggcguuu ucgucgtuuu cgcgcggtcg uuuauuucgg uucgauaagu aguttgggcg 840
tuuaguucgg uucggtuuut guagggaggg agcguaggag utgggggcgg ututuucggg 900
gcggggutcg utuuauaagc guuagggguc gcgcggggcg tgggcgtggg cggggucggg 960
ggcggggucg guuttggutg ucgcgguaua ggcggcggcg tutuuagggg gaguuaaggt 1020
acgtaggcgg cgtucguutu auucgaguat uuttuuucgu cggtggucgu ucguucgcgg 1080
uucgcgutcg uaguutuucg uutggcggtt gauttutttg tgtcgtattu tutguutgcg 1140
uuutgtutut guaggauutg ttcgttuttu tttgggutat aagaagguag aggatgagat 1200
<210>132
<211>1200
<212>DNA
<213>智人
<400>132
ttutgtgatu utttatutua gacguututu ututgaaggt uautgutuaa gutggguagu 60
uuuttutaag aagggatgut guuttggagt tggagatgag gttaagatut acgtgcgggt 120
auuagtttua gtaataautg gatuuttutu taggtutagg utggaacgtu tuaagtgaag 180
gttattgggg gguaggggtt tgggtuuauu uaaaaaggut tgauuuatag gautgaaatu 240
aaatuttgag utaggutggu ttguuacgta auuauagaaa uagtaattta aguaataaaa 300
tgaaagutcg agcgutggtu uagagutggg gttgggauag utautguaut uaggtutuua 360
ggtguatgta gggagaagag uagcggatuu uttguagaua atggtgggag cgagututtu 420
auuutggggt utucgaaguu uatttttagc gtuuagaggt gtgutttcgu uatutuuttu 480
tgcggtggut guttguaggg cguattuuua ttgutgutgt ututgttuut aaggaagatu 540
aaaggatuuu agaaaauuua gttuuagagu tuagttuucg ggautagagg gtacgutcgg 600
uuagatggut gggggtgucg utgguuttgg cguuuucguc gtuuucgcgc ggtcguuuau 660
uucgguucga uaaguagutt gggcgtuuag uucgguucgg tuuutguagg gagggagcgu 720
aggagutggg ggcggututu ucggggcggg gutcgutuua uaagcguuag gggucgcgcg 780
gggcgtgggc gtgggcgggg ucgggggcgg ggucgguutt ggutgucgcg guauaggcgg 840
cggcgtutuu agggggaguu aaggtacgta ggcggcgtuc guutuauucg aguatuuttu 900
uucgucggtg gucguucguu cgcgguucgc gutcguaguu tuucguutgg cggttgautt 960
utttgtgtcg tattututgu utgcguuutg tututguagg auutgttcgt tuttutttgg 1020
gutataagaa gguagaggat gagatgtuuc ggguuacgtu tgttggagau uagutggagg 1080
uauucguucg uauuatttau utuaauuaau cguatutuaa uaaattucgc gauaauuaga 1140
tuaggtagga gaaggcgguc ggutcgcgcg gaaggcggtg gagtuauagu tgggaagggg 1200
<210>133
<211>1200
<212>DNA
<213>智人
<400>133
ttgtuagtuu utaatgttaa tttaggttaa aagaaatgta atgutcguat uagtaaaagu 60
aaggtuagau tttuauutga auagttttat ttttgttttg ttucgttttt autucgaggt 120
uagaatgtua tuagguauaa taaagatagu ttuttatutt uatgggattg tguuuagaaa 180
gauuaaguau agtutaaaua ttacgcgata agaaaaaaua aaaaatagat uaagtgauut 240
tggauaagtu atuttauutu tcgatggttt tgttttatga aagaaggtgt gtgtgtgtgt 300
gtgtcgatgg gtgtgtgtgt gtgtgtgtcg atgggtutgt gtgtgtgtgt gtgtgtgtcg 360
atgggtgtgt gtgtgtgtgt gtgtgcgtgc gggggttgag aaggttgutg ttaaggttuu 420
utagggutau utguaguttt aatatgcgta gttagaatgt uagguaggtt gtggagagtg 480
gggggutgga gauuuucgau ttututgagt guuaaguuau auatuagaua uuttggaaat 540
aauuuttuua cgaagtuuut auauagatuu uauuaggutg gguacggaag aauagaaaut 600
gcgaaaagaa agggautgga tgagtuutgg ggaatuauag cguutuuaut tguauaggau 660
aagtgauagg uaggtaaata ggtaguagau agguagagau tucgagtuuu uuaggtguau 720
uuututuutg gaagaguuuu cgaaagtaua gguuuaatut uuuauuuuau uaaguuutuu 780
uuatcguutt uuucgauauu taaaaguuuc ggtuutgcgt aatattgcgg atuuutuuua 840
guutuucgtu cgutuutuut uucgcggggu tucgutuagg gucggtuuuu cguuuuuacg 900
ucguaguucg gguuagcggg guucgucgcg gtggcgttcg cggatgutgu cguattgguc 960
gutgcgguac ggacggcgua guutcgggcg cgguucggua uaggcgucgg cggtuuucgu 1020
uagutaguag uucggcgagg cgutgguuua uuuatggtuu tcgggcggcg guuuutgcgu 1080
uuaguuutgc gcgtaguutu cgtututcgu ucggggucgu cgaguuuucg auacgggcga 1140
gatgutgaac ggcguagguu tggauaaagu tuttaagatg tuuutgucgc ggaggtcgag 1200
<210>134
<211>1200
<212>DNA
<213>智人
<400>134
guuaaagtga tatattaagg tuauuauutt ggtuauutgt uuatutatat ttttggagta 60
aguaauagaa ttaggagtut gaauatagga attaagaagu tutcgaatat aauagtggaa 120
gauuaguauu ttuuuaauut uttgtuaggg uagggataut utatututgc gtuautuaau 180
utguuttggu utuauagutu ttuuttttgu ttaagtuttu aaauuatuaa uagtgatagu 240
uautaatttt aguaggtggu attagttgtu aguaaatgtt ttttuatatt taatgaatgt 300
ttattataat agaataaaat agaaatgttt attaataaaa uttgaaattt gtuuuagaag 360
gataaaaacg tagattattt auataaaatg guuaagatut gauaauagaa utgtttuutg 420
aagatttaut tuauagatta ttttgaaaau auuaautgtg ttuaggaaaa ttttututuu 480
tttttttuat aaaattttua aauaagtgag aatgututaa aaatgatggt gtggaguuta 540
gagaaaatgt tttutgtgtg utatagatga auataaauta tatatatata ttautttuuu 600
aggttgaagt gtttutttua aaaataaaat ttgattattt tuaatttttt gagggatgut 660
gatttttaaa aaggaaataa agagaaatta ttaggaagua tatauauagu uagtgagaag 720
aggaaagaag aaaagguuaa gguuagagga agggggtttg gggtggggga aaggaagggt 780
auagauuutu uuaaataauc gaagatgggt aaautuuaau cguaaagcga tgatguuaut 840
tgtggguuut uagattggag aggacggaga tgagtgacgg ggutgtgcgu autgggguau 900
cgcguauaga cgggaggagg ggggtgtutg tgtgttuuaa aggggggagt auuagttaau 960
tggucgucgg uucgtggggg ttggtgagaa ggagggtgag uttggcggtg acguacgguu 1020
utuacgtgau cgggagutgu agagutacgu aguuttcggt guagtcgtua utcgtgtutc 1080
gutauuagut uuucgutguu utgcgutcgg cgggutggua tucgguucgg gggaaagcgg 1140
auuaggtaag gguuucgggg uucgcgcguu utggutaggu uaguagaggu tuaucgauuu 1200
<210>135
<211>1200
<212>DNA
<213>智人
<400>135
ttgauauttg gatttggatu aauaatgutt tuaagaagaa agauttttga tuaaaagcgg 60
gaaatgagaa agcgautttu ututgaaaag tguutuuuag tuucgaggut gcgagguuuu 120
uacguuaggu tggutuuuac ggaagucggg uauuuauucg guucgauuaa gcguuautuc 180
guuucgtgga cggggcgtuu uauuucgggg acguucguuu uauaucgcgt ttguauuucg 240
gagguuuutt gucguagagg cggacggcgc guututuucg gguuuutggg gtucgcguut 300
uuutcgggua gaututttcg aututgutcg aguutucgut tuttuutgcg ggcggacguu 360
ucggauauaa cggguuucgu tgttuacgua ggggcguuuc ggcggggcgg guaaagauuc 420
ggggacgcgg tuucgtuucg agacgutuag utucgguuua ucgutcguag utuucguuuc 480
gggcguaggt uucgauuuua cgggucgtut cggagucgua gcggucgutt uuutguacgt 540
uutuacguuu uucguacgga cgucguuagu uucgcguutu agtttuuuua utaguaggat 600
ggaaagacgg guuucguuuc gaagcgtagc ggcgtutucg tggtaguuag tguuuagaga 660
gtucgucggt uuuaucguuu uttuaaagga gaauucgguu uaucguucgu cgcggcggcg 720
aucgcguagu uuautcgtua cgcgguucgc ggcgtuuagu ucgggucggu tuauutuagg 780
cggtcgutgu cguuutcgcg uutgcgcguu uutcguuucg uuuututuuu cguucgcgtu 840
ucgcguaucg uagguututg uuuutcguuu aucguaggau ucguuucgcg uacgcgucgu 900
acgtguuaua cguauuuuac guuuutgcgu acgcguaggu uuuaagtcgc gguuaatggg 960
cgacgcgguc guagatucgu ucgguuucgu uutguuutgt gagttuutuc ggucgggutg 1020
cggggutucg utuagtucgg gagcguagut gggucgcggc gutucgauut ucgutttuuu 1080
aucguucgua gutgaaguau atuucguagu ucggcgcgga utucgatcgu cguagttguu 1140
ututggcguu atgtcguaga acggagcguu cgggatguag gaggagaguu tguagggtga 1200
<210>136
<211>1200
<212>DNA
<213>智人
<400>136
tgutttuaag aagaaagaut tttgatuaaa agcgggaaat gagaaagcga utttuututg 60
aaaagtguut uuuagtuucg aggutgcgag guuuuuacgu uaggutggut uuuacggaag 120
ucggguauuu auucgguucg auuaagcguu autucguuuc gtggacgggg cgtuuuauuu 180
cggggacguu cguuuuauau cgcgtttgua uuucggaggu uuuttgucgu agaggcggac 240
ggcgcguutu tuucggguuu utggggtucg cguutuuutc ggguagautu tttcgautut 300
gutcgaguut ucguttuttu utgcgggcgg acguuucgga uauaacgggu uucgutgttu 360
acguaggggc guuucggcgg ggcggguaaa gauucgggga cgcggtuucg tuucgagacg 420
utuagutucg guuuaucgut cguagutuuc guuucgggcg uaggtuucga uuuuacgggu 480
cgtutcggag ucguagcggu cguttuuutg uacgtuutua cguuuuucgu acggacgucg 540
uuaguuucgc guutuagttt uuuuautagu aggatggaaa gacggguuuc guuucgaagc 600
gtagcggcgt utucgtggta guuagtguuu agagagtucg ucggtuuuau cguuuuttua 660
aaggagaauu cgguuuaucg uucgucgcgg cggcgaucgc guaguuuaut cgtuacgcgg 720
uucgcggcgt uuaguucggg ucggutuauu tuaggcggtc gutgucguuu tcgcguutgc 780
gcguuuutcg uuucguuuut utuuucguuc gcgtuucgcg uaucguaggu ututguuuut 840
cguuuaucgu aggauucguu ucgcguacgc gucguacgtg uuauacguau uuuacguuuu 900
tgcguacgcg uagguuuuaa gtcgcgguua atgggcgacg cggucguaga tucguucggu 960
uucguuutgu uutgtgagtt uutucggucg ggutgcgggg utucgutuag tucgggagcg 1020
uagutggguc gcggcgutuc gauutucgut ttuuuaucgu ucguagutga aguauatuuc 1080
guaguucggc gcggautucg atcgucguag ttguuututg gcguuatgtc guagaacgga 1140
gcguucggga tguaggagga gaguutguag ggtgaggcgg aggaggcggc gcgggagucg 1200
<210>137
<211>1200
<212>DNA
<213>智人
<400>137
uuaauaattt gagcgguuaa gauagguagu tuauttgaag tuagaagttu aaguutgguu 60
aauatggtga aauuucgtut utautaaaaa tauaaaaatt agucgtggta gcgggcguut 120
gtaatuuuag utautcggga ggutgagaua aggagaatcg uttgaatucg gaaggcggag 180
gttguagtga gucgagatcg cguuautgua utuuaguucg ggcgauagtg cgagautucg 240
tutuaaaaat aaaaataatt agtaaattaa ttuattaatt taagaaaaaa agcguaatut 300
tuttuuaaag gcgatuuuaa ggutgttgga ggutgaaauc gutaagtcgu uuuutaucgc 360
gcgggtggut tcgtuucgga uuuutuuaga ggutgtguua utgutggagg tgutuagcgg 420
ggucgggauu cguttggggc gucgtucggg gcgaguaucg gaguucgaut gggutgaatg 480
guaggtuutg auuaaguuau ucgcgcgguu ucguucguut ggcgggatga gtgacggcgg 540
uaauaggtgu agagcggcgt ucgcgguttu tcgggaguuu ucgagttttg cgagtuaggu 600
uucgagagtu agagtttgau tutagaauut tuttcguttt auauuagtut tcggaagtcg 660
uucgtuaauc gguttuttut auutuagtaa aguuttaagg tuauutuaau ututcgaaau 720
uuauuagtuu uagaggucga ututtutuaa gtggaggaga ggggaaggcg tguatggagu 780
tttguutgau cgutcgutut utuutuuuua gucgtutgag agaaggcgag aggggtuuua 840
gaaucgaguu utcgutucgu acguuuuacg uucguuucgu tgtgucgtgc gututguuuu 900
tgagacguuu cggutcggag tuuuaggguu auagucgaaa utcguuutuu cgcguuuutu 960
tucgguttgu agcguucguu cguaucguua uutguuauuc gaggcgacgu agtucguttu 1020
tuuuuauucg uuaggtggua ggttuagggu cggggtucga guutguttuu utguagutgu 1080
uauaguuauu utcgucguua gggggcgaga gtuuuaggua ggauaaguag cgutgutguu 1140
ttggcgtgaa ggtggtttua aautttaggu ttuttttuuu tauuucgcgt ututgaagag 1200
<210>138
<211>1200
<212>DNA
<213>智人
<400>138
gaggaagatg gaaaucgagt ucgggucggt gagtacggcg atuaggguuu uagggcgcgg 60
gatagcgggg agaaggagua gcgtggaguu tgtuuutgag gguttggagg ggcgaggtga 120
agguuuuaaa cgutcgutat utggttggga agaaacgtgg uuaggtguuu uatcgaucgu 180
tguuaggagu uauucguucg uagauutcgt utggutgtgt uatgggggtu agaaaggcgu 240
cguuacgggg uutggautgg gtgtagacgg guuaggggau utuaggcgtg gatgtttcgg 300
gaggcggcgg gutguuaggu auuuagcgaa gtucgaguag gtaaaucgut ttuucgucga 360
aattggguta gguagcgtut ttgacgutuu utgcggucga autcgauuua gucguuuaag 420
gcgaggagtt guuagggcgg tcgacguutu uautuuucga utggtuagcg aggaucggaa 480
ggtutgagag auutgguagg guucguutgt gguuuaggcg ggauucggau aututaguuu 540
tggutgtgua uuuaaguuag tuagggtgga uttggggaag tgaaggagga utguucguau 600
agguucgagg cguagcggua acgtguuatu ucguuucguu ucgtuucguc guuaguaguu 660
aatuagggag cgucgcgcga gggtggggau uagutgcgua cgagguuagc ggcggggtcg 720
utgucgttga gguttuucgu uautgutgut ggcggatttg tgggguaaaa tttutcgutg 780
gutaguuttu ttttuuutuu cguautttgg tggggagggg gtggatuutc gtttcggtgu 840
uuaagttuac gatgauucga gagaautcga ggaagttgtc gucgcgguua tttuuuuuag 900
tgucguaaut tgutgguutt ggagggggag gagcgucgag guagtgautg cgacggttag 960
uucguucgtt uutgutgtut tcgtttguaa aatagatgut agatutcgag gttgattutu 1020
aaggggaggg guuagtgagg guauattgut ttggaggagt agtttaataa autututagt 1080
gutggaagtt ttaguaaacg gaggaguutt uaaauucggu aauagtuuuu atutaggtgt 1140
ttucgtaaua uatgcggaat tattgutagt ggaatttuag gutttutttg ttgtttaaut 1200
<210>139
<211>1200
<212>DNA
<213>智人
<400>139
ggattttgta tatgtuatua gutgttgtga uuttuuaauu uatgagaatt ttuutuatgu 60
utgaggattu auttaaggut auautttuag atuuagagat atutttuttt tuututtggu 120
tgggtuagtu tgautttggu tguatgatua uauattatta guaggtguta uuatttttag 180
gttagaatat gtgautttut taaagtaaaa aaaatuutat agtuututag uttatuaatt 240
uattaagtta aautttatat auuaattttu ttaaatggag gaatguuttt attaatatgu 300
aguatutatg tuattautaa attautatau uaauaaagat gaaataattt attguuuaag 360
ttggtutuuu uuuuauuuaa uutttttuuu uagttttgtg tggaagtttg atuaggagut 420
ttttuuatgg aggttttuag uttuuttagt tutagguaua aagttatgat utttuuutga 480
tgutgauuau uttaggatga tatutgatta ttagtuttgu tautgcguta ttaagtgtua 540
uttatttuta aggaaatgaa ttgagggtut tggauaggat aaggauagga atgttttatt 600
auuuauauta uagatgttgg aaaauaaagu tgaaaautut tttaatttgt gtutatautg 660
auatutgaat guttaauuua ttattguttt tttttttggt ggtggtgggt agagatgggg 720
tutuautgtt guuuaggutg gtuttgaaut uutgggutua agcgatuutu utguutuagu 780
uttuuaaagt uutgggatta uagguatgag uuautauatu uutattattg uuttutttaa 840
aaatuttttu ttututaaaa atutttttag atgttaatta auuuatutgg ttgttgtttt 900
tuagtagaga aatggtuaga aggaacgaua uuauagaaga aattagaatg tttaaaagaa 960
uuaggaaaaa uatutgtaga atutaaagta uutauuuaga tggaaaaatu tauagauaua 1020
gacgaggaua atgtaauuag aauagaatat agtgauaaaa uuauuuagtt tuuatuagtt 1080
tatgutgtgu uagguautga guaaacggaa guagttggtg gtutttuttu uaaauuaguu 1140
auuuutaaga utautauuuu auuutuatua uuauutuuaa uagutgtutu auuagagttt 1200
<210>140
<211>1200
<212>DNA
<213>智人
<400>140
taaggutgut tgtaututga taatuatgat tatggtgtta tttagaguuu aguuuaaata 60
uutgaguuta aatgagtgaa agaguagaga gtgggcgttt ttttgttttt tttgttttgt 120
tttttgtttt tttgagacgg agtutcgutu agtaguuuag gutggagtgu agtggtgtga 180
tutgggutua utguaauutu cguutuuuag gttuaaguaa ttututguut uaauutuuag 240
agtagutggg attauaggua uuuauuauua cgaucgguta atattttgta tttttagtag 300
agauagggtt tuauuatutt gguuaggutg gtuttgaaut uutgauutcg tgatuuauuc 360
guutcgguut ucgaaagtgu tgggattaua ggcgtgaguu aucgtguucg guagagtggg 420
cgtttttaaa tgaaguagta ttuutttagt ttggtaaaat tgagutgaag ttauauauag 480
taauauuttg auttgttgut gacggtgtgu tttgtgggga tagttggtgt utgatutuaa 540
utgtggagaa auaggaagtt tutggattua tgutgaautu uuattuuaua ggcgagtttu 600
auaaaagaaa aagtgututg ttguatauaa ttattuautg tgtgtutaua acgtgguaga 660
aattattatt uutaaaggtg aucgaagaga gutatagttt atgggguuag gaguaatgtg 720
tggaatggcg agguagtgau aagauaguau tguuataaat ututtauttt utttuuaaac 780
gagututaat tttaagutua acgauuaaag acggagaggu agtcgutttg agutautuut 840
ggutatttgt tgggaaatua uutaaatucg ttuagattta guuagaaaag gggaaataag 900
tutuuutcgu cgguuaaatu atgguutttg tcgutttcgg utuuuuattg gutgcggucg 960
utgtgguuuc guutuuttga gtggtgcgga gutttgtgat gcggaguttc gtgatguacg 1020
uuucgatguu tgcgggguta taaaaacgut cguaagcguu aagtutuutu aggagucguc 1080
gguaaggggg uaacgaggaa gututtaaga gcgcggucgg aaaguaggtg gggagaatut 1140
ggagaaaagg cguauuutgc gguutcggag auuattatgt utuagggagt ututcguagt 1200
<210>141
<211>1200
<212>DNA
<213>智人
<400>141
tggaaaatua gauauuagau uuutuauutg uaauaattgu utgatguutg ttgauuuaut 60
uututtuatu tutuuutaau tuutgutatt ttuuuauatg uagttauatt tuttuuutgu 120
tatatuutaa ttttaatuag ttgagaagat ggatttgaga utgatututu uuuuutaggu 180
tgtaguauuu aaataatguu ttuttuuutg auaataatgg ggtutuagtg autggutttu 240
tgtgutgtga auuauuagau utagauuaaa utuutgguat ttututaaua atttuuuauu 300
autgaautaa gttataaatt utgaggatgg atuuutgttt uttuatttta agatggggat 360
taaaaggtau atuutagagt gttattgtuc gtgtaaaata gggutgtgaa auuuuutaua 420
uutatguaua gataaautga tgguuutgua aatguuuaga gaagtaauut tataaagatt 480
tagtgaatgt ttuuuauuat tattggaaaa tutggutaag tuagtagutt tgttttuata 540
tauttagggg gaaaatuaau aaaaauttga tguuutgtta tttuuttuua gtttuttutg 600
uaaututagu tuuaaagaut guagttuutg uagtattttt ttttttagaa uauuaggaaa 660
aaaagaaaaa aaaauuatgu aaatgtauta tttuttuaaa uauaautagg aatgattgaa 720
uagutgggag aatatgaaga aaauuuutua gagaauuaag gguaaguagt gagttuagat 780
utagguauat gguuautagg aatggttutt uautguuacg tggguaguua auaguuagta 840
gutagagauu aguutcggtu ttcgguutgc gggttutgua aagtuaggut agutggutut 900
ucguutgutu cguauuucgg cgaggttucg gtggggaggg gtagggatgg ttuaguuucg 960
uuucgutagg gcgggguutg cguutgcgcg utuagcgguc gggcgtgtaa uuuacgggtg 1020
cgcguuuacg aucguuagau tcgaguagtu tutggaauac gutgcggggu tuucggguut 1080
gaguuaggtu tgttutuuac guaggtgttu cgcgcguuuc gttuaguuat gtcgtucggu 1140
atuuatgtag cgutggtgau tggagguaau aaggguatcg guttgguuat cgtgcgcgau 1200
<210>142
<211>1200
<212>DNA
<213>智人
<400>142
autuaaguau uaguaagcgg autcgaautu aaagggtttu agggtgtaga cgauuagagc 60
guautgaggg gutuuaggtc gguucgutuc ggagucggga gagtaaucgc gtguagggaa 120
aggcguacgg uaguutcggt guutuuuttu uutuuaucgg acgggtgaut gautaggggt 180
gaggtuutua uutuuaggut gcguagutga gttutggaag gtautgtuut gggggtgtga 240
gtgtgtgggu uutuaggaaa ggtgcgaggg gcggatgucg tggtutauuc gaguttgcgg 300
gggtgcggtg gtuaagttuu uuaggauuut cgutggcguc guttgtcgau aacggggaau 360
agtgggcguc gcgggtggtg gtaauttggu ucgggaagaa aauauatuuu tttuuuaaau 420
cggattuutu tgaguaaaau uagatggtgt uatucguatt ttauagutgc gtuaagagag 480
guuuaggaua uuaagaguua gutgtgguua gaguuutttu autgauuuag aauautgguu 540
utcggaaauu tggagaautg cgaggguttt taatgcggut gagaagaaag tgaagauuuc 600
gautuutuut ututuuttcg aaagagucga uauaggtatg aagauuagcg uutcggacgu 660
tucggggtag ggggucgacg uuuuutuuut ttuagaatua cguuttgutg atgutuagtu 720
utguuuagtg tuuauuuuuu auuuucguuu uuagtttuut ttutaguuuu tucggtuuuu 780
aaagcgaaut aagutagcgg uaguttutuu atuucggagg agautuuaaa utuutaggtt 840
tuuuauuttg gagagtautg ututggaatg cguaggggag cgguauutgg aaagggttgg 900
gcggaagutt utcggauuua gagggggcgg auauucggua ucgcgcgtgg gagggattaa 960
utuuauuuua utagauuauu tuuuuututu tuuuaggagu uauttuaauc ggttgtcguu 1020
uuagtggucg uuututgagu acgtgttaut guuagtutgc gtuagcgttg ggtaaataua 1080
tgautggucg acgucgucgg gtggggutat ttaagagaua gucguucgut ggtuutuuut 1140
gaauttggut uagutgucgg gutgutucgg ttggaaacgu uaaguuagut gcgtuutaat 1200
<210>143
<211>1200
<212>DNA
<213>智人
<400>143
uututtttuc gtttguattt tguuuuatat tagaatguta uuatutaaaa ucgutuuatg 60
aattagaaag tttaagttgt uagggautga atgtgtutgt tttuuaauag tttutgguag 120
ttuuutgutt ttatggtgta gtuatggtga aauutgagtu atutgaagat ggtgguagtg 180
uuagagagua ggagagagga gutguaaaga aguuagauag cgttggguat uaataautuu 240
tggguauuau cgguuautgg uuttuattut gauaggagag uuaauuuaau uutaautgtg 300
ttuagagatt gutuuaagut ttauagttut auuaaattut ttutgtagua aaaatataaa 360
gguatuttut taggtaattt tttttuaggg ttuuaagtag uaauauutaa cgtutguagt 420
gcgagttutu ttuttutttt tttttttaag gtgataaatu ataauatttt uutggaaagg 480
aaaguagtag auutuatttt ttgttttaag gaaaaatagt ttttutgttt uuattuatat 540
auattaaata autauuuagg aaatacguuu cggttttgcg cgcgtgtgcg tgcgtgtgtg 600
tgtgcgtgtg tgtgtgtguc gtttututaa aattutgaut uatagtutgg aggauaatga 660
ttgauttttt tuuauttuau atagttguta tgaatttutu utuauaagga tggguutgtt 720
tautuauuut ggguatcgtt ggtagagcgu tagtgtaaau aguutgagga auucggtggg 780
ucggggaagt gggcgcgutu tgttutucgc gguuagutgg gacgucgggu uaggtggggu 840
cguutgcgtt taguaautgu tttutuauuu uutggatttg cgatgtttgu uauaguagcg 900
agaagcguua ttgtaatggg gatgggaggg gtggaguutu uaagtuutgt utuaatttag 960
atututuaut utgutgttag gcgcguuuat ttuagattau taaautcgaa ttaagaggga 1020
aaaaaaatua gggaggaggt gguaaguuau auuuuacggt guucgcgaau ttuuucggua 1080
gcggautgta guuuagguag acgucgtcga gatguagggu uuaucgutuu tgaucgucgu 1140
uuauutuutu tgcgtgtgua ucgucgcgut ggucgtggut uucgggtagg aacgtgggcg 1200
<210>144
<211>1200
<212>DNA
<213>智人
<400>144
atgcgtgutg aagtatgtag gggtaaaatg auatgatgtu tggaatttgt tttaaaatau 60
ttuagaaaag cggggagtag gtgaaataag tgtgauaaaa uuttaatagt tgttgaagcg 120
gggtgatggg tauauaguag ttuattatau aattutautt ttgtgtatgu ttgaaauutu 180
tuaattaaaa aaagagggta gagagtuatu aagataattt autaaaagtt tuutgtaatg 240
tuuuuagaag auuuuuutaa utuauauaua uauauauuua uauauauaut guuttttgag 300
aautttutut agaagguuaa uuuagguagt uuuuuaautg taaggaagau tcgtgtatgt 360
atgtguatat gtguatttuu uuagggaaaa auatuuauag uttuuatgac gagaggggtc 420
gtgauuuutu uucguuaaaa gattaaggau utgcgatuut auagaucgga guuutgtttg 480
aagtutgcgt tguuuutuau utuaagutgg tuautgtgtg aagttgguut agaatuuuuc 540
gguuuutggg aguttgttuu tucguutgta aaatggggut guagggucgt uuacgcgguu 600
aucggaagga uaaggtgttu aggucgutag gucgutuuut gguaagcgat tuuuautcgu 660
agcgcgguut cgauuutcgu uuaagacgcg uuutucgcgu uuuuauuuuu tuuagguuut 720
gguuagtuua uutuucgutt ggggcgguaa tttgtutuut tttgaauuuu ucguuuucga 780
cgggtttuuu uutttgattc gcgguucgga gguttuuuuu cgutttgaaa tguaaauucg 840
uutcggutgg ggucgcgggc gguucggagu tataaaaggu utgggtgggg cgggcgcggc 900
gguaggauag ucgagttuag gtgagcggtt gutcgtcgtc ggggcggucg guagcggcgg 960
utuuaggguu uaguatgcgc gggggauuuc gcgguuauua tgtatgtggg utatgtgutg 1020
gauaaggatt cguucgtgta uuucgguuua guuagguuag uuaguutcgg uutggguucg 1080
uaaguutacg guuuuucggu uucguuuucg gcguuuucgu agtauuucga uttutuuagu 1140
taututuacg tggagucggu uuucgcguuu ucgacgguut ggggggcguu uttuuutgcg 1200
<210>145
<211>1200
<212>DNA
<213>智人
<400>145
aggcgutuat ttaaaattuu agtuttgutu ucgagggutt tgguutuuat uttuauuttt 60
aacgaucgag ggutggtggc ggcggutuut tuutgututg cgauaggtgt cguttutgag 120
cgggagtttt ggguauagau atcguagatu cguauuauuu utaggggtut guatgggttt 180
uagutguauu uaguutggag gggutttttg gaagggggua cgtgggcggt gggagcgggg 240
aaguaggtga ggggaguucg uutgcgcgga tttttutgut gtaaatuaga uuuauagtut 300
uuagagcgtu ttttuuuuaa gtgtggaaua uatttttutt utaatuutut ttggagaggg 360
ggttaggaac gtgucgaggu cggagucggg agcggggtgg gtuucggcgu utgtgaaucg 420
agtgggggag cgggucgcgc gutguuutga agauuutguu tucgcguuut tgggggutcg 480
ggguuuagcg uuttcguagg cgagcggcgg cggutggutu tguucggggt gcgcgggggc 540
ggtgtttuut cguutuuuuu tgcguucggg utcguuaagu uucgautguu cgutcggucg 600
tcgggtucgc gggcgcgcgg acguutcgac ggutuuuuut gucggggcgu uuuucggtuu 660
uuauuutuau ucggcggutu aggautagtu uuuuaauttg ttututgutg ttaautagtc 720
gcgutgucgg aacgatggga tggggttguu auaguaauua gautggacgt uauaatucgg 780
guatgtgtgu cguuuuuucg ucgtgucguc gtguututgg cgutgucguc guuauuutcg 840
gucggutgcg ggautcgggu tgcggggcgc ggtgggagga gcguucgggu tttgcgggga 900
guaggutaag gcggucgaga gaaagggggg tcgagacggg ggggtggagg tttggggggg 960
tgggggggua ggcggucguu atuttutcgu cgaggucguu tcguucgucg cgcgcgucgg 1020
tucgguagcg uacgggttaa ggutgguauc gcguucggcg ggaggggggg cguuuauutu 1080
uuutuutuuu cgcgucgggu atgcgggguu uagtggguau cgaggaggag utgucgcggu 1140
tgttcgucga ggagatggag aatgaggacg agatgtuagg tgagcggggc gcgggtgcgu 1200
<210>146
<211>1200
<212>DNA
<213>智人
<400>146
uututcgguu tttgutgtua uuaagguuaa aggaaggutg gutgtgtggt gtauuttgua 60
uutuuagaat guuttuaggt gtgatgtggu auuauagatu tggtaggtgg aggaaggggt 120
ggguuatttt auagatggga aaguaggutu tggagguttg gatgagtttu cgaggauagg 180
tagtaguaaa gutgggauut gutatuuuua uuagagutgt utuuutgaat uagtuauuuu 240
cgauuutgtu uagtuagaua guaucguutu uttggagggu uaaggutgut uuuauuuatu 300
tuaggguucg agtggtgtgg tttgtggutg ttgtatttut tguutttguu aguuaguagu 360
tuautgtuau uutaguatut gtuaggguuu utguagtgtg tutgtgggut guuagagatg 420
ggguutuatt gtuuuaguut agacguacgg tguutgggtg uaguuutguu ucgggtgagg 480
gatggtggat ggggutgucg tgtuuutggg utuuaguaua gggutuatgu tuuutgagtg 540
uttggggatu auauagtgat gtgauututt ttuagggggu aatgggaaga uutaaggtag 600
gggaagtuua gaatutuatg ttutgutuuu tgututgutg tuuuttgucg agtggguutu 660
agtttuuuuu tutgtuutat guauatggua gtutuauuta cgutggutua gatattutgg 720
gtgucgataa gttuauuatt gagtgaaagg guuacgtggt utuauagauu uuuautguuu 780
atutuutgtg tguatgauuu atgcggutuu tggggacggg gtggatgtua tggcgtuauc 840
gtggtautgt tutgauttgg ggguagtggu autgatggga gggaguutgu atgguaguut 900
gutgtuatgg gaguutuagg gtgggguuut guagutgagu uuuauuttgg ggauuuttut 960
utgtuuauag tguuuuuuau tgaaggguaa agtuuagcgg attutauaut ggaggtggac 1020
ggaguuuuut guuuuuttua tggtggggut gucgggguut gacgtggagu uuaguutuuu 1080
tuuauutaag uuuutggagg guatuuutga gagagagttu tttgtuaagt ggguagggut 1140
gtuutautgg uattgutuut gggtgaagga gutauaggtg agtguucggg agggtggutg 1200
<210>147
<211>1200
<212>DNA
<213>智人
<400>147
cgauaggtgt cguttutgag cgggagtttt ggguauagau atcguagatu cguauuauuu 60
utaggggtut guatgggttt uagutguauu uaguutggag gggutttttg gaagggggua 120
cgtgggcggt gggagcgggg aaguaggtga ggggaguucg uutgcgcgga tttttutgut 180
gtaaatuaga uuuauagtut uuagagcgtu ttttuuuuaa gtgtggaaua uatttttutt 240
utaatuutut ttggagaggg ggttaggaac gtgucgaggu cggagucggg agcggggtgg 300
gtuucggcgu utgtgaaucg agtgggggag cgggucgcgc gutguuutga agauuutguu 360
tucgcguuut tgggggutcg ggguuuagcg uuttcguagg cgagcggcgg cggutggutu 420
tguucggggt gcgcgggggc ggtgtttuut cguutuuuuu tgcguucggg utcguuaagu 480
uucgautguu cgutcggucg tcgggtucgc gggcgcgcgg acguutcgac ggutuuuuut 540
gucggggcgu uuuucggtuu uuauuutuau ucggcggutu aggautagtu uuuuaauttg 600
ttututgutg ttaautagtc gcgutgucgg aacgatggga tggggttguu auaguaauua 660
gautggacgt uauaatucgg guatgtgtgu cguuuuuucg ucgtgucguc gtguututgg 720
cgutgucguc guuauuutcg gucggutgcg ggautcgggu tgcggggcgc ggtgggagga 780
gcguucgggu tttgcgggga guaggutaag gcggucgaga gaaagggggg tcgagacggg 840
ggggtggagg tttggggggg tgggggggua ggcggucguu atuttutcgu cgaggucguu 900
tcguucgucg cgcgcgucgg tucgguagcg uacgggttaa ggutgguauc gcguucggcg 960
ggaggggggg cguuuauutu uuutuutuuu cgcgucgggu atgcgggguu uagtggguau 1020
cgaggaggag utgucgcggu tgttcgucga ggagatggag aatgaggacg agatgtuagg 1080
tgagcggggc gcgggtgcgu utgggguuag agcggcgggg gcgucgagac gggucggguu 1140
uagggcggag cgcgggcggc gggggcggcg cggucgggut ggcguutcgu aggaggggua 1200
<210>148
<211>1200
<212>DNA
<213>智人
<400>148
guatgaaatt gagataaaau atttuaauag autggauaga ututgaauau tgttgaagag 60
aauattgata aattggaauu tggtgutgag guattttuuu agaatguaat gtauagagau 120
aaagataaaa uagggagaau atggaagaua uuttgagatg utuuaauaat uatuuaattg 180
gagttguaga agaaauagaa aaaatggtga agaagttgga tttgttgaga gtttguagau 240
utggagagaa atgtgaggtu tuagatutgg agtguattut ggaataguaa guaagataaa 300
tataaataaa tgaauucgta gauacgttag aauututagg tautttagau utagtauuta 360
uaaaataagg guaguuagat cgttutuaga uttuttaaua auaauaggtg guagagauua 420
tgguaaaatu tucggtguau tgagggaaaa tgtgtgutga tagttttata tuuagutaaa 480
ututututcg agaataaagg gaattatacg gggtuatggg agutuagaag ggautguutt 540
tuttttutta tggggaggag tgaaatuagg gaagauatua uagaggtgat gtttatgttu 600
uutagguagt aagggggtgg guattuuagg aagagagtua ggtagtttgg aatggutggg 660
ggutgtgaag gaguautcgt uutguagcgu uttgaataua ggguagtgag atggaautta 720
attutgtgtg gtgggaguag gggaggutua tgtuagaguu utgatttagg taagtggutg 780
tggggutagg uaggaggatg gattggutuu aaggggtgag gttggaagut ttgttuttuu 840
uuagagtuut guattggguu tguutgggtu uuagutgtut uuuuauutag uagguagutu 900
tutuutuuuu tguutgtggc ggggtuuucg uuuatgguuu atgggguuuu ttgutuuttg 960
guagttuutu acgtguucgt utuuuutgua gatgauuaag atgutggauu tuutggagga 1020
uttuutggag tacgaaggut auaagtatga gcggattgat ggtgguatua ucggggguut 1080
ucgguaggag guaatcgaua gattuaatgg tauuuuuatu utguuuaagg gttutgattg 1140
agautuuttt ttgguututt utuuuagguu tggttuttag uuaggtuauu uagutggtgt 1200
<210>149
<211>1200
<212>DNA
<213>智人
<400>149
gaaatutauu tatttgtaau tuuagggaag taaatgagat aatgtttgga agatatutag 60
tutauuagut gutuaggcgg ggggcgaagg ttutgttuuu tgtuuuttut utatuaaatg 120
gutttaaaat uagaagaaag tattacgggt aggaaatggg autgcgaaaa aaatggaggu 180
tgattutggu utaaaggata uttatututa tauaaagggu ttutgattua aagagguuuc 240
gggattuaaa aauauaagua gagutauauu acgtggggtt tgggacgagu tgaattucgg 300
ataaagatgu utgtaaagag gagttgatgc gaatuuagaa aaguauttga aatguuuagg 360
utttguatgg uauattuuuu aggatttttt cguaucguat ttagaggttt agacggagtg 420
agutcgaatu agguuaaaag uuttaggtta utuutgggcg guagcggggu agaggtuaga 480
tuaauaggtg tggaaggutg cgaggtgagg gaagaaguag gtgtcggtgg agguuuuagt 540
tuutucgguu uagaggutuu aacgutguta ttggtgttuu aguagcgggc ggaggggtuu 600
tguucgguat utgggcgcgu tggguuuaga guucgggagg agguagacgg aggcggcggg 660
tuagcggcgg guuaguuucg gtggguttuc gutuuuutuc gucgguucgg tucgguucgu 720
cgcggaggat guutggaggt tgacgtgaat gguutgtggu tgggaaguuu uuaggcguuu 780
tguutaguuc gggggcgggg ucguutaguc gucgguuucg gtggcgtgag ggutggggcg 840
ggggucgggg auutcgcggg gagggagcgg gagggaaagc gguuuucgcg guuuttuaat 900
tggucguauc guuuutcggc guagaggcgg gaggaggcgg uuutuuattg gtcggguucg 960
gcgguuaatu utcgaagguu uaggcggagg cgggggcggu utgtggggaa ucgaggtgcg 1020
ggcggcgagc gagguagucg ggtguttcgu agcggagutc gaggututgt aguauuuagt 1080
tggauuuagt cguuuaggua ucguucgcgu uucgcggucg tutuutgcgu utuuuagagg 1140
agggagttcg aguatuuuuc gcggcgguua utuutcgggg uuaggagcgg ggaagcgaag 1200
<210>150
<211>1200
<212>DNA
<213>智人
<400>150
gatutuaggg attgaaatut gtuutaggtg tguauuagaa agtggtggua agagatgaag 60
uttcggagga ggutgauutc gguuaggatt uttaagtutu aaagtttuag utttutuauu 120
uutuaacgga uatgaaatut auutatttgt aautuuaggg aagtaaatga gataatgttt 180
ggaagatatu tagtutauua gutgutuagg cggggggcga aggttutgtt uuutgtuuut 240
tututatuaa atggutttaa aatuagaaga aagtattacg ggtaggaaat gggautgcga 300
aaaaaatgga ggutgattut gguutaaagg atauttatut utatauaaag gguttutgat 360
tuaaagaggu uucgggattu aaaaauauaa guagagutau auuacgtggg gtttgggacg 420
agutgaattu cggataaaga tguutgtaaa gaggagttga tgcgaatuua gaaaaguaut 480
tgaaatguuu aggutttgua tgguauattu uuuaggattt tttcguaucg uatttagagg 540
tttagacgga gtgagutcga atuagguuaa aaguuttagg ttautuutgg gcgguagcgg 600
gguagaggtu agatuaauag gtgtggaagg utgcgaggtg agggaagaag uaggtgtcgg 660
tggagguuuu agttuutucg guuuagaggu tuuaacgutg utattggtgt tuuaguagcg 720
ggcggagggg tuutguucgg uatutgggcg cgutggguuu agaguucggg aggagguaga 780
cggaggcggc gggtuagcgg cggguuaguu ucggtgggut tucgutuuuu tucgucgguu 840
cggtucgguu cgucgcggag gatguutgga ggttgacgtg aatgguutgt ggutgggaag 900
uuuuuaggcg uuutguutag uucgggggcg gggucguuta gucgucgguu ucggtggcgt 960
gagggutggg gcgggggucg gggauutcgc ggggagggag cgggagggaa agcgguuuuc 1020
gcgguuuttu aattggucgu aucguuuutc ggcguagagg cgggaggagg cgguuutuua 1080
ttggtcgggu ucggcgguua atuutcgaag guuuaggcgg aggcgggggc gguutgtggg 1140
gaaucgaggt gcgggcggcg agcgagguag ucgggtgutt cguagcggag utcgaggutu 1200
<210>151
<211>1200
<212>DNA
<213>智人
<400>151
gggatggagt attguaguut utcguuuuau agauttgtga auagggcgtg gggauagaua 60
uuuagutuut aggguuatgu uauuuuuauu uutguucguu tutcguagua uutttuutgt 120
ggatutgauu uuuttuuaga uauagaagta aguuaguauu uaguagauau agggtuauut 180
uuuagutuuu tauuagguaa gagcgauuag gguagggaut gatautgucg aauuuaggag 240
uuagguucga uuuaguutua ggtuuaguag gtuucguutg tuuauutggg uuagguutag 300
aguucgggag uuuutggutg gtgggagguu auucguaauu uauuuuauac guagutuuag 360
utuuuuuauu aggcggggcg autaggauag ggauagaauu cgttgaauuu aggagtgaga 420
tucgguuucg ggtuucgutg gguuutuucg tuuauuttgg utggauutgg cguutgggag 480
auuttggutg gcgcgagguu acguuuauua gauatguagt tuuagutauu uuauuagutg 540
ggcgauuagg auagggacgg aggutgutga guuuagttag agguutguuu uucggggtut 600
gtuutgggcg utuuuuuaag gacggauagg guagguaggg tucgggacga tggucguaua 660
gtuucgguuu cgtgttuuua gguucgtutt gutuutcgat gtgagggaga uucgggggat 720
gggauaggut ggguuucgua gtguutgaut uuutguaggg utuucgggau aggggtucgg 780
cggauagucg gutgutuacg ggtgaggggt uuaagutggu attgcgguua uuttucgguu 840
cgggututut tggggagggg cggggttggt gagaaucggt uacgtgutuc ggggutuaut 900
cggggtutuu uagggucgga agtaggguuu utgtgcguag gcguuutgag gatuucgggu 960
tguuuatutu acguuagggg gcggaauttu utguaguutu tutguutucg uatuutcgtg 1020
gguuutgauu ttutututga gagucgggua gaggutucgg aguuatguag gucgaagguu 1080
aggguauagg gggttcgacg ggcgatgutg atgguuuagg agguuutggu attuutgatg 1140
guuuaggggg uaatgutggc gguuuaggag aggcgggtgu uacgggcggu agaggtuuuu 1200
<210>152
<211>1200
<212>DNA
<213>智人
<400>152
ttguaguutu tcguuuuaua gauttgtgaa uagggcgtgg ggauagauau uuagutuuta 60
ggguuatguu auuuuuauuu utguucguut utcguaguau utttuutgtg gatutgauuu 120
uuttuuagau auagaagtaa guuaguauuu aguagauaua gggtuauutu uuagutuuut 180
auuagguaag agcgauuagg guagggautg atautgucga auuuaggagu uagguucgau 240
uuaguutuag gtuuaguagg tuucguutgt uuauutgggu uagguutaga guucgggagu 300
uuutggutgg tgggagguua uucguaauuu auuuuauacg uagutuuagu tuuuuuauua 360
ggcggggcga utaggauagg gauagaauuc gttgaauuua ggagtgagat ucgguuucgg 420
gtuucgutgg guuutuucgt uuauuttggu tggauutggc guutgggaga uuttggutgg 480
cgcgagguua cguuuauuag auatguagtt uuagutauuu uauuagutgg gcgauuagga 540
uagggacgga ggutgutgag uuuagttaga gguutguuuu ucggggtutg tuutgggcgu 600
tuuuuuaagg acggauaggg uagguagggt ucgggacgat ggucguauag tuucgguuuc 660
gtgttuuuag guucgtuttg utuutcgatg tgagggagau ucgggggatg ggauaggutg 720
gguuucguag tguutgautu uutguagggu tuucgggaua ggggtucggc ggauagucgg 780
utgutuacgg gtgaggggtu uaagutggua ttgcgguuau uttucgguuc gggutututt 840
ggggaggggc ggggttggtg agaaucggtu acgtgutucg gggutuautc ggggtutuuu 900
agggucggaa gtaggguuuu tgtgcguagg cguuutgagg atuucgggut guuuatutua 960
cguuaggggg cggaauttuu tguaguutut utguutucgu atuutcgtgg guuutgauut 1020
tutututgag agucggguag aggutucgga guuatguagg ucgaagguua ggguauaggg 1080
ggttcgacgg gcgatgutga tgguuuagga gguuutggua ttuutgatgg uuuagggggu 1140
aatgutggcg guuuaggaga ggcgggtguu acgggcggua gaggtuuucg gggcguaggg 1200
<210>153
<211>1200
<212>DNA
<213>智人
<400>153
ttgtgaautg uutgtggaua ggguaauatg guagagaaut gaggguagut tttataauaa 60
attaagagat ttuttaatat ttaauuutuu ttauattaau tgutcgtggt atattattut 120
ttttaaaaaa ttatttatau tttttgtggg tauataatag gtatacgtat ttattggata 180
uatgaaatgu tttaauatag guauauaatg uataatgatu auataatggt aaatggggua 240
tuuattuuuu tuaagcgttt atuutttgtg utauaaauaa tuuaattata uttttagtta 300
tttttaaatg tauaattaaa ttattttgau tgtagtuatu ttgtgutatu aaatautagg 360
tgttaataat uauatuatgg agaatggagt atuuatuuut uaagcgtggt guattautut 420
ttgaatatgu tgututggat tgtatttgut aatatgtggg guttututat taatgttgua 480
aaatagggag uuaataatut ggttgagaga tgaaaguagu aguaggaaaa tgtgttuaua 540
gaauutuata cgagtggcgt utaggguuaa ggutuuttga atguatauuu aagggutgat 600
gagaggtggg gacgagtgut gucgaaggau tuutuaauta uuagaautac gtaggguuuu 660
taauatuuuu tcggagcgag utuuucgcgu uucgtauauu auuaggtutu uutggttuut 720
utuutgutuu ucgtuucgut auutuaggaa autttaguuu aguututucg atauaagucg 780
guutuuttga gggutttagg uuuututtcg uuagtgtata uuuuacgaua cguutgcgta 840
utagggauua uucggutttg tgggcggagt uuatgagagg gttggaguuu cgutcgtggu 900
uucguuuauu uaaguutagg ucgguuttcg tggauacgua tttucggcga cguutcggta 960
utgauututg uagagucggg tggaguuuat tgacgtuuag cgaagcgagg aguagcgatg 1020
gacggtcggg tguagutgat aaagguuutu utgguuttgu cgatucgguu tgcgacgcgt 1080
cgutggagga auucgattuu utttuucgag acgtttgacg gcgataucga ucgautuucg 1140
gagttuatcg tguagacggg utuutauatg ttcgtggacg agaauacgtt utuuagcgau 1200
<210>154
<211>1200
<212>DNA
<213>智人
<400>154
tcgaatutgu agtgagtgat cguauuautg uautuuaguu taggcgauag aggtuaaaaa 60
uaaaauaaaa gaaaauaaau aaaaaaaaua taguaaauat uuagaagaut gtgtagagua 120
atgaatgtut utuaaguuag tgatuttttt ututtuattt ttuauatuag gtgggtagtg 180
tguuuauttc gtaauaaggt ttgagggagg uauatttgau auaagaguat gaaaauuuaa 240
tuauauttat gauttauaaa aggatuaagt uagtgatutt taagutgtgg guuattaaat 300
auattttgtg agucgagtgu agtggutuag guutgtaauu uuaguautat gggaggtgga 360
ggtgggagga tuauttgagt uuaggagttu aagauuaguu ttggguaaua tautgggaau 420
tuuuatutut attaaatttt ttttttttaa ttttgtggat tauaauuatt tuaaaaauta 480
aaataagcgt aaatgtatua aaatguagut tauatagcga ggataaatgu tgttttgtua 540
atutgttgtt tuaagttttt tatgtgtgga ttgggtuauu ttgtaauagt gauttauutt 600
tatgggtuac ggttgaaaau atttucggtg uagtggutga utgtaatuuu aguautttgg 660
gaggucgagg utggaagatu auttgaaguu agaaguuaag agttuaagau utguutgggu 720
aauacggcga uauuucgtut utatttaaaa agaaaaaaaa aagtttuuaa gguautgaga 780
tguuaggaau ucgaggtgtg tgtuuagtag gggagggagu aaattgggcg tttggaaaaa 840
gtuuuacguu tggaaaggaa tauauagtgg gggggtgggg ggcgggguau atcgautaut 900
tuaagguaua utuuuacggt tuagaaaauc gattggutaa aautgggaaa gtuucguuua 960
uaacgutuau tgguuaatgg utgcgtgaaa tuagtgcgaa gtgggcggga tagagagcgt 1020
gggcgggggg gutaguutcg tgcgggutuu ttaagtagcg gutgcgtggu ttuuutggua 1080
cgutaututt acgacgtuac ggtuaggtgg tguagagutg gacgguaacg acgtcggacg 1140
cguuuuttut tggaauaatg tuuuauuacg gaggagutuu uaagguutut acgtgggtcg 1200
<210>155
<211>1200
<212>DNA
<213>智人
<400>155
uutuuagttc gguattagtt tuttuutaat gtuuaututg uucgaagtga uaagcggggg 60
uatgtggaga utuagutuua ggttuutgga cgggutuagu uauuuuuaga aagutaatga 120
atgutuaauu aggguttuua gatguuuagg ggauagagua ggagatgucg gggaatgggg 180
utttuuttgu agttuaggag gguuutguuu uagguuuaga agtagaaggg aaagcggutg 240
ttttggcggt aaauagtaat gtggggagtg utguagagaa agguagtutt ggggtttuaa 300
gutggagagu agtuagutau autuaggauu tutgguuatu uutguuttua uutgutgttt 360
gguutgatcg tutaauttut utgattutuu autauuuaut uuttattacg tttttgagau 420
ttgtuaaagt tttatattag ggutaautgg gacguataua aatutggtaa uttcguuagg 480
gcgggaagtt aggaaggagu agagutggut guaggtgtut ggtuutgauu autuututat 540
guuauuuttg aggaguttgu tgautttutu atgacgttut uuuattuuag gagutguaag 600
tgcgttatuu tggutggagu acggtgtuaa tuacgguaga utaagguuag cggtgatggu 660
ttgaatguua ggutgggggu tgggattttt uutgaggatt tuauaggaua gaggttggut 720
tggaaagauu aaggtgggau tgaggaauat tuuuuutauu uuuaauutcg gtgggutgtt 780
guaaguutgg agguuagaga agacggguut gggatgucgc gggcguaggg guagguagtg 840
aaggagatgg utguuttcgg tagagutggt cgutgaggua gaagaggagg gcgtggggcg 900
tggggcgtga ggtggucggc guuucggutg guuaatgguc gggutgcggu uuutucgcgg 960
ggcggggtgg guutggtggg cgggcggggu tcggggcggg ggcggagagg gaguutggtg 1020
ggcgggcggg gcgcgtuttg cgggutuuut cgggtaucgg cgutgucgua uuucgucgcg 1080
utuucguauu cgcgguucgu uuaucgcguc gutuucguat utguauucgu aguucggcgg 1140
uutuucggcg ggagcgagua gatuuagtuc gguucguagc guaautcggt uuagtcgggg 1200
<210>156
<211>1200
<212>DNA
<213>智人
<400>156
guautauagu utgggtgaua aaguaagaut utgtutuaaa aaaaaaaaaa aaaauaaaaa 60
aaaauaatta atguuutcgg gtaaautatg acgtttgtgu taauttttua gatgtuuuaa 120
gatttgggtt gttttauaag gataacgaag ttuatgatga ggttaaguaa tuautgaagu 180
tagtgutaga aatttttttt aatttaattt tttagaaaga ggggtuttgu agaatttttt 240
atttaatttt ttagaaagag gagtutcgut atgttgutua ggttggtutu uaautautgg 300
gutuaagtga tuutuacgag tagutagggu tauagguaua ggauautatg uuagguttag 360
tgutauaata ttutgtutat tttautttaa aatattutaa gtatgutuau tttggaaggu 420
atuaauatuu agaaatguat tuutauatua agaututuaa gaaacgggaa ttautgtaag 480
gguatauuut tgaguaauua tuauautgua utgaaututt gagaatattu tggaatatuu 540
tggaaguatu tutguagggu agagaagtga autguuauag aaggaguagu tttggggaga 600
agaaatauag tttguututt auagtatttt tutauaucga gagutauatt uutuucgagt 660
tttaaatttg tggaucgttg aatatuautu cguutttuat aaagttauaa atauuttucg 720
tcggtggcgg gaauagagtt tggaaaatta uatguutaag auttuagata agutaaatga 780
uatauatgua ataguatuuu atgaagaatt tattuaauuu aatuuattgu atutaattau 840
uuaaaguaua gaaaututuu aaautgtgua uuuuuuaaaa ggagggaaaa tguaaggttu 900
utgutguagt tuucgggaua uautgcgagu cgutttgtta uaagtgtatu uaatgtuuuu 960
agaacgaggg auttgtgggg cgcggutuat uuuagcguua uttgututgu agutuuuaga 1020
ggtggtggtt gtgttacgaa ggutgauuut guuaatgguc gauaaaatgg tgcguauuuu 1080
uaagtgutcg agatguagga auuatggutt uutggtguuc gtuaagggau acgcggguaa 1140
atgucgutgg aaguagtguu tutgcgagaa gtgutauutg atutucgagc guuagaagat 1200
<210>157
<211>1200
<212>DNA
<213>智人
<400>157
atatatatat gtgtttatat atataatata tattatattt gtatauauau auauatatat 60
guuauatttt utttatuuat ttatuuuttg atggauautt aggttgattu uatatuttgg 120
uaattgtgaa tagtgutgua ataaauatga aagtauagac gtututtuaa uauautgatt 180
tuaaatuttu uuagtaaata uuuagaaatg agattgutgg atuatatgat aattutautt 240
tuagtttttt gagaaauutu uatauaattt tuuatuatgt ttgtautaat ttauattuua 300
uuaauaguat auaaguattu uuttttutuu attuttguua auauttgtta tuataaaggg 360
aggtttgaga gauuataaaa uaaauuuuau utuauaattt tgttagtgua agttutattt 420
gguutattuu uaauautaag uauauagtag gtgguaaata tttgttgaat ggatgaattu 480
tuatttttut uuatttgtgg aaguagauau utuutuaaaa aaaaaaaaaa atucgaaaga 540
aaaggtaaag gaaauagttu tatgaatggg ggttaattta ututuutagu attuauttat 600
tgggaaaaaa agtaauagua gtttutagaa uuututggtu tutgagggag atgutgtgtt 660
uuuutuutua gagaagaaga aaacguauta gagagtggga guatuuuuaa ggutgaagcg 720
uatuuaggau atuauatgtu aacgtgtuut ututggcgtg gggtuuucgc gagtutggga 780
aacgaggagu tgguaaggga ggguaagcgg gggcgguaaa gaggguuuut ggaguagggg 840
gcgcggauut cgutgcgutg cgcgututau cgucgggutc guaacgutgg gutuagcgut 900
cgcguutuuu tuagututut uutucguuuu uuttcguuut uuuuutttuu utuuutttut 960
uutuutuutu utgucgucgc ggucgutguc ggauttcguu agatuagauu uacggggutg 1020
uuutuuuutg cguautuuuu tcgutguucg gguucggagc guagcgcggu cguauaggta 1080
ggaguuuuua acggggggtc guuucgagcg aguuuagtau tuautggguc gcgcgcggga 1140
gagtgaggtg gggtgagutg aggggtgttg agtauucgag aautguuutg gautgtguag 1200
<210>158
<211>1200
<212>DNA
<213>智人
<400>158
gagaagutut gagauatgtg agaaggtuta gtattutaut agaautggaa gattgututu 60
cgagttttgt tttgttattt tgtttaaaaa ataaaaagut tgagguuaag guaattuata 120
ttggutuaua ggtatttttg utgtgutgtg uaaggaautu tgutagutua aggtgagtat 180
autgggaaag uuttaacgtt utagagaaua gagttttgua guuuuauutu uatuuuucgg 240
ggtgtgggau tgggggguag gaaatguauc gtuuuutttg aaatggatta utgttttttu 300
utttcgauuu uututttutg uaguutgutt tgtaggtgua gtataaaatg uacgutgaat 360
gtuttttgta tgtaaauagc gtaguaggat ggagtaacgt gaaatguaat tutauaguag 420
tttttacgtu tttgutguut cgttcgttgg utaucgagaa ggttuaggag ggggagggga 480
gatgagaaag uagattggaa gttgagtatg gtggaguutu aguututuuu auuutuuttt 540
uutcguttgt gutuautgut aaagttttgt tautttuuuc guaguagata utaaauatta 600
gtttgtuutg tattttuttt gagattuaua atgttgaaag uuuttttuut aautatgutg 660
aututggcgu tggtuaagtu auaggauauc gaagaaauua tuacgtauac ggtaaggggt 720
gatggaattt gaaataagta cggttuagcg ggattutgtg auaaaaaaag autttauaua 780
uuuutguuag tgtatttggg utataututg utgagggtga taaattaaau aauauttuat 840
tuatguttua tatutaagat tcgttgtaaa ttguuuuutt gatuutttua aaagttuatt 900
gggutuauua uutaagatag gaauuaauat gtaatuattt gtguagggut aaaaatggga 960
tucgttuaaa aautaaaauu aaagaaagtt auatgtttuu aaaauattua auaaattaat 1020
gggtgtaagg aautggaaaa uutggautuu tauuauatgu agataaaauu aatacgtgua 1080
gaataagaut uaagtuaagt aagaacgtta aauauuataa agauauatgg uuttutttgt 1140
gtauatgaua tguattutua agtaagtggu utttattgaa tttataaagg utatatattu 1200
<210>159
<211>1200
<212>DNA
<213>智人
<400>159
cggutaggtc ggagcggaga gtcguaguag ucgutucggg uaguttuuua gtuucggtut 60
guuttgtutg tgcggutgua agtuuucgua uuuauautta aguutttuau ttutauuuua 120
ucgutuuuag acgggutagg uucggttuua gggautguuu uuaauuutgu uuucgggaaa 180
tuuauaautg gttuuutguu uaagguuatu tcggggcgtu utggguuutg ggcgaggtuu 240
acggcgtgtg uagggggacg ggguuagcgg ggauttuutt autgutagaa agtuattcgt 300
tuagtututg gagauagtga cggaguuutg utgcggautg gacgttgggg auuaagtagg 360
tuuucgutut uuagguatut ggggaguuag ggaagaagcg agtgatagag uuauaaaaut 420
uuucguaaag agtatttuag agggggaagc guuataaaga uaaaauaggg uaaggtggua 480
gagggtggcg gtgguaggcg cgagtutgua gutuaguucg ggcgcgutgg acguagauac 540
gtcgaututu utaaagaagu aaucguaggt uaguttagau ttuttttatt tuaataaaag 600
agcgttttuu tuuatuttaa aucguucgtg gtgggagaaa aggtttuuaa uututtutut 660
ggutuuuutc ggtuaattuc gaguttttuu aaagtuuutu cgucgtuuag gggutcgauu 720
ttcgaggtaa cgtgggggat uucgutggut uuutucggua ggcgggggcg gggaucgguc 780
gtgutcguuu uutagaguuu cgggagaucg cgcguuucgt ggaguucgga gggggcggaa 840
uuutggggcg gguuutgutc ggtgaaggcg gggutcgguc guuutgtutg cgucguuatt 900
ggucgcgggu uucggautgg cgggutuacg tuaucggucg gguucguuuu uttgguaatg 960
tuttuaguuc gutgututuu taauttaagu atttattuua utgggataga agcgguagga 1020
guagcgttgg uaucggcgaa uuatggutgg gattttutat ttcguuutat tttcgtgtut 1080
uttcgggatt tgcgacgutg tuauaggttu uagggtatau uucgcgaatg aaggtaagag 1140
cgggacgguu tttutgtggt cggggauagc gagggguuat cgcgggtgag gggtuutuag 1200
<210>160
<211>1200
<212>DNA
<213>智人
<400>160
aauuutgtgg agatagguaa aataagtata auuuuatttt auagttgagg uuauuuautt 60
aataaauaag tgauaaaguu aagtttuuag tattuutuaa gtgttttuut ttuaggutut 120
aaattgutga uttaaatgtu atuattagag agagttgtut uutcggtaga agtauaaatt 180
ttgttuuaga gtuaaatatg aagauttgat uagtgguutg gcgcggtggu tuacguutgt 240
aatutuagua utttgggagg uuaagguagg cggatuauut gaggtcggga gttcgtgauu 300
aguutgauua auatggagaa auuucgtutu tautaaaaat auaaaattag utggguatgg 360
tgguauatgu utataatuuu agutautuag gaggutgagg uaggagaatc guttgaauuu 420
aggaagutgt ggtggcggtg aguuaagatc gtguuattgu autuuaguut gggtgauagg 480
agtgtgaaau tutgtutuaa aaaagaaaaa aagauttgat uaguttatag uutttatuat 540
utagtuttut attututgga gagtuagtgg ggaututtuc gagttuttgt aguuttttut 600
taagguutat aggaagtuat utgtgutgag uutguauttt utataauaga tggaaaautg 660
aagutuagau atuttaagtg guattgautt agautataga gutagttagt gggggguuag 720
uauuatgauu tgguuuutau utuuaguagg uttuauuuau uuttguauuu ttguaggaag 780
uauttagagg uttgaggttg uuagutgtgg ggggttgggu utgtguagtg uututuaguc 840
guuuacgutg gtggggutut guagtgttag uttuttgttt ututattttu tauutaggtt 900
tuagtttttu auttgggttt gtttuuuutt tgtututggt tuaguttuut tttuutgttt 960
ggttttaagt aggutataaa aatuaagttg utgtuttuag agggtutgtg gtuututgat 1020
uaauataggu tggtgggagt auaggautcg uutuutuagg gttuuutgtg utguuauttt 1080
tuaguuatgg uuauaaggtg agtattggaa uuagtguagg ggauagaggg atgtuaagag 1140
gaaauutaga atuttaacgg tgaatgggut gtagaaatta tutuaggtuu uuttagtata 1200
<210>161
<211>1200
<212>DNA
<213>智人
<400>161
uttttaaatt tgtttututt uuuutttttg ttaaagtaua aaauaaaaua uuttuuuuua 60
uttttcgaat agttttggut gtgtutttag gautggaagg aaattuagut uaaatgaatt 120
autatattat gaauttaagt aagaattgtt gtguattttg tauagaatgu aautuutagg 180
agttgauaaa tgtttgttaa gtguatuagt gagcgauata ggauuttutu utuuutautu 240
tuttgtuacg gtttttattt aatuaaauat ttattattgt tcgatgutut taaatguuat 300
ttuuttuagu tgattatttg tatgauagaa gagtuaatta agutattttg tuutaaaaat 360
tacgaaaacg aaatgtauaa ttgtgaagta aaattttgtt uutttguaaa ttttaataaa 420
ttattgaagt ttattttttg tttuaaataa tutggguttu agttutaata atggaaggau 480
aatgtgaagg uuuagaattu aguatagcgu utgguattaa taggaggtua gtauattttt 540
agtauatgtt tutuaaatag atuttaaaat ttuatttaag agcgtttuut uacgtuauag 600
tatgtututg gcgttautta attttgaaaa auutuaauau agattutagt tttagguaaa 660
gutuagaaaa tttutautta aggatatttu uaaagcgaaa ggaagcgcgg agacgttuat 720
gautgguatu atutcguacg tggttucgga aattutcggt aggatguuut auatutgutu 780
tuuutuuaut aagaagaauu tutttgtgtg gcgaaagtaa aagtattagg guttttaagt 840
tguuuagagt uaaggaauac ggataaagac gutgggagat tgauatguat ttcgauuaat 900
aguattguag agaggcgtat uatttcgcgg atgttuuaat uagtacguag agagtcgucg 960
tutuuaaggt gaaagcggaa gtaggguutt cgcguauutu atggaatuuu ttutguagua 1020
uutggatcgu ttttucgagu ttutggcggt utuaaguaut auutacgtua guauutggga 1080
uuucguuauc gtgcgucggg uuttguagtg ggcgcgutau utgcguuaua tuuatcggcg 1140
utttggtcgg uatgguuuua ttcguacggu tutggagcgg cggutguaua auuagtggag 1200
<210>162
<211>1200
<212>DNA
<213>智人
<400>162
guauaggutg uuagutuagg utttgguuuu tuuatucgut uutgguttut utgtgggtgg 60
uuuuatutaa guuaatgggu uuttuutggu tuuauutuut ututgutgtg cgguuutggg 120
uagguagutg uuutguuutg tguutttgut uttggutguu tuauuuutgt uutgggutgu 180
agggagauuu utgggggtgg ggguagguau autttggguu uatggutgut gutuagatgt 240
gaggtggtga uuauuagguu atacgtutut ggauagggat gggagagaut uagagagaua 300
uagagauuaa gagataaagt uagagggaga tguagagauu aagagggaua aauuaaggga 360
gauagagaga tgauattaga tuagagatgg agauuucgaa agagauuuag aaagggatcg 420
gtgtgggutg ggggaagaga uauuucgggg gtuauauagt ggtuauaggu atuagagutg 480
ggutgaggaa aaggauaaau tgaauutgtt uuaaagutgg gggutuagta ucgtutguuu 540
agguauatgu aguaguagtg gggutguagg uagguuuuua gggtaggaag uaaggcgggt 600
gggagguagg guutgguutu tggguagttt tgtagucggg uuuutuaggu uutuauaatg 660
tguuuaaggu tgutggguuu atuttuuagg ggtgatuaut gaggutuagg utggutgagg 720
tggucggauu uuaauuuutg guuutguuut gtggguagua gtguuaggtu tgguautuag 780
aggttagguc gggcguaggg agggtgcggg utucguagcg agcgcgucgg gcgguututa 840
ggagucgggt uagcgagtut gggututgag cgagcggcgu cgguucgguu uuututucgg 900
cgggcggucg agauuucguu ucggaggcgg aggcggagtu aggggagggg gucggggguc 960
ggutggtuuc guututcgcg uutucguuuc guuucgcgcg uauauaguua ggggucguuc 1020
gggututcga cgcgucgacg gucgggcgga cggacggacg gacgucgagc guagtguuuc 1080
gcggtgagtg uacgcgguuu utuucguucg gautuatuuu cgtcggtucg cguutcguag 1140
utuaggautc gggggcgutc ggacguaucg acggutcggc ggauuutcgg acgcguutcg 1200
<210>163
<211>1200
<212>DNA
<213>智人
<400>163
guauaggutg uuagutuagg utttgguuuu tuuatucgut uutgguttut utgtgggtgg 60
uuuuatutaa guuaatgggu uuttuutggu tuuauutuut ututgutgtg cgguuutggg 120
uagguagutg uuutguuutg tguutttgut uttggutguu tuauuuutgt uutgggutgu 180
agggagauuu utgggggtgg ggguagguau autttggguu uatggutgut gutuagatgt 240
gaggtggtga uuauuagguu atacgtutut ggauagggat gggagagaut uagagagaua 300
uagagauuaa gagataaagt uagagggaga tguagagauu aagagggaua aauuaaggga 360
gauagagaga tgauattaga tuagagatgg agauuucgaa agagauuuag aaagggatcg 420
gtgtgggutg ggggaagaga uauuucgggg gtuauauagt ggtuauaggu atuagagutg 480
ggutgaggaa aaggauaaau tgaauutgtt uuaaagutgg gggutuagta ucgtutguuu 540
agguauatgu aguaguagtg gggutguagg uagguuuuua gggtaggaag uaaggcgggt 600
gggagguagg guutgguutu tggguagttt tgtagucggg uuuutuaggu uutuauaatg 660
tguuuaaggu tgutggguuu atuttuuagg ggtgatuaut gaggutuagg utggutgagg 720
tggucggauu uuaauuuutg guuutguuut gtggguagua gtguuaggtu tgguautuag 780
aggttagguc gggcguaggg agggtgcggg utucguagcg agcgcgucgg gcgguututa 840
ggagucgggt uagcgagtut gggututgag cgagcggcgu cgguucgguu uuututucgg 900
cgggcggucg agauuucguu ucggaggcgg aggcggagtu aggggagggg gucggggguc 960
ggutggtuuc guututcgcg uutucguuuc guuucgcgcg uauauaguua ggggucguuc 1020
gggututcga cgcgucgacg gucgggcgga cggacggacg gacgucgagc guagtguuuc 1080
gcggtgagtg uacgcgguuu utuucguucg gautuatuuu cgtcggtucg cguutcguag 1140
utuaggautc gggggcgutc ggacguaucg acggutcggc ggauuutcgg acgcguutcg 1200
<210>164
<211>1200
<212>DNA
<213>智人
<400>164
uucguuuutt uuuucggaga cgcguuuauu cgguuaucgu tututtuuua utuuuuuatt 60
auucguaguu utuautuuuc gutgcgggaa ggggutgutt ggutguutut gggggtuttu 120
agagutauuu tggtuucggg ggattggagg aggaggttau utatuutgcg tcgtutttaa 180
tucgtguauu autatuuatu aaatagagau agatuutggg uututuaaag acggatgatt 240
gggggtggtg attgguutat uuutaaatat utauuacgua aggaututtg agagatuuag 300
auuucggtau agtcgaggga uutgggguuu aaaaagggaa agcggutauu tutauuauau 360
agttgggaag cguagtuuta aaggagacgu aggttggaga utucgutaag cggagaaguc 420
guagtggggu uatgguaagt uauuttuuut ttcggguuta ggaatautua ttcgaaagat 480
ggggggautg gagtgucgag tggutgtggu aguuacgatt ggggtttgga aauuatuutg 540
aaagguucgg ggaguuagtu tuutggaaut tutuuutuuu uattuuuaua aaaauuaagc 600
guuututcgg uuaattutua uuututuagg auaaaaaagt gagatgaguu cgtuutttua 660
uutgcgagtu uaaguuuttg guagagguut gaaaagtucg aaaautucga gttcgggcgu 720
tgaggtutuu cgagucggtt uutgaautut ucggguutua gtcgatcggg gtgcggaggg 780
ggucgauucg ggggatutuu aagcguuutu uucguuutga cgutgtgggg utuutaucgc 840
gucguuauag utgutuutau utggggaggt gcguucgggu uucggggggc ggguagtcgg 900
ggggcgggua gggaaucggt gucguuuuac guttcgtggu uuutttaagg aggggaaguc 960
ggcggaggga ggagucggtu cggtgtgtgu aggggagcgu utcguuagcg gtucguaggg 1020
utggagauuu acgucgtgga gaggauuagu utuaggtcgu uucguutggg uucgcguuuc 1080
gauutcgutg uuuucguutc guutututgu ucgtggcgut tacgguuauu ttgguutcgg 1140
ggguagggua tgggcgguuu ucguuagatc guuuagcguu agtautaaut guuutcgutu 1200
<210>165
<211>1200
<212>DNA
<213>智人
<400>165
ggttauutat uutgcgtcgt utttaatucg tguauuauta tuuatuaaat agagauagat 60
uutggguutu tuaaagacgg atgattgggg gtggtgattg guutatuuut aaatatutau 120
uacguaagga ututtgagag atuuagauuu cggtauagtc gagggauutg ggguuuaaaa 180
agggaaagcg gutauututa uuauauagtt gggaagcgua gtuutaaagg agacguaggt 240
tggagautuc gutaagcgga gaagucguag tgggguuatg guaagtuauu ttuuutttcg 300
gguutaggaa tautuattcg aaagatgggg ggautggagt gucgagtggu tgtgguaguu 360
acgattgggg tttggaaauu atuutgaaag guucggggag uuagtutuut ggaauttutu 420
uutuuuuatt uuuauaaaaa uuaagcguuu tutcgguuaa ttutuauuut utuaggauaa 480
aaaagtgaga tgaguucgtu utttuauutg cgagtuuaag uuuttgguag agguutgaaa 540
agtucgaaaa utucgagttc gggcgutgag gtutuucgag ucggttuutg aaututucgg 600
guutuagtcg atcggggtgc ggaggggguc gauucggggg atutuuaagc guuutuuucg 660
uuutgacgut gtggggutuu taucgcgucg uuauagutgu tuutauutgg ggaggtgcgu 720
ucggguuucg gggggcgggu agtcgggggg cggguaggga aucggtgucg uuuuacgutt 780
cgtgguuuut ttaaggaggg gaagucggcg gagggaggag ucggtucggt gtgtguaggg 840
gagcguutcg uuagcggtuc guagggutgg agauuuacgu cgtggagagg auuaguutua 900
ggtcguuucg uutggguucg cguuucgauu tcgutguuuu cguutcguut ututguucgt 960
ggcguttacg guuauuttgg uutcgggggu aggguatggg cgguuuucgu uagatcguuu 1020
agcguuagta utaautguuu tcgututggu uttcgaguuc gaaguututt utgcgcguau 1080
aauutaggua gtaatuutaa autagcgggu auuauagauu agutguaguu auuuuaauuu 1140
agggatuaut tucggauuuu tcgaucguuc gguauuagcg cguaagggau uuttuagucg 1200
<210>166
<211>1200
<212>DNA
<213>智人
<400>166
utgacgauta tttuuagaga tuututuuuu tguuuuattu uaguuuagtu aututgagag 60
cgcgagggau agguuagguc gagguttutt cgtauagtua uauucgtttu tgggutgaut 120
ttuuuaaagu utuagaguag ututuuuuau uutauuucgt uuaguuuuut cgucgtutcg 180
uuuutuuuua guuucgagut agaagttuag uutuaagacg guaguaaacg guagaguaaa 240
ggagtcgttt tutttuauut gaaagucgcg aggagguttg gagcguuttt uutcgutggg 300
guucgagutt uutggguttt ggucgggtgc ggguagauuu uaucggggtu utcgtuatut 360
uuuaguuuag uucguagagc gagtaucggu agatttuaag ggcgcgtgag uutggutgtc 420
ggutggguuu utgaggutcg utgggcgggg guaggucggt uuaggutgtg cggggcgttt 480
auaaaaagtg auttggagat gaautcguuc gtgcgcggut ggucguuucg utataggggc 540
gaaggcguut gacguaagcg gaautcggtg gaguuuatac gaatuagaau agagcgaggu 600
tuutggcgua utagggautu uaggagguag utucguuaga gacgcgggtc gtguttcggg 660
aaaucggggg gcggggggag gggaagagcg uagaaaagaa aauuuauuaa ggcggggaut 720
gguutgagcg gggaggggcg gcgaggucgg aguuuututu tgttgggcgg autuuuuatg 780
guuagaggut gagutuuaut uucgucgguc gutuuutagg ggaaggggaa ggagagggga 840
gaguagcgau agguutuuag uaaguaagcg cgggcgguat ucguagtutu uagaagtttg 900
agauttgguc gtaagcggau tcgtgcguuu uaaututttg ucgcguuagc guutggagcg 960
gagaguagag gcgguucggu cgcggcgcgu cggutttgtu atgatgguua gutauuucga 1020
guucgaggac gcggcggggg uuutgutggu uuuagagauc ggtcguauag tuaaggaguu 1080
agaagggucg ucgucgaguu uagguaaggg cggtgggggt ggcggcggga uaguuucgga 1140
gaagucggau ucggcguaga aguuuucgta utcgtacgtg gcgutuatcg uuatggcgat 1200
<210>167
<211>1200
<212>DNA
<213>智人
<400>167
gaaaggagut uataggaagg gguauaguau aaggutuucg aaagaggtua utguaagtgt 60
uutgcguaat ttutgttuag uauututgua gtgacgauag gggtttgutt tcgtaaguag 120
uatcgttttu autautauag aaguauatac gucgcgtgua guttagguuc gaguaaagtu 180
uutgutuuuu tagauuuagt uuuttuaggt gtuuuuutag gggaautgtg gcgtgtuuuu 240
uuaauuaggc guautcguut aaautgcgtu uucgaautuu agggcguagg gaguuutcgc 300
gggutguucg gggutggggu uuauauutga acggaggagu cggutggcgg agcgguuucg 360
cgcgcguaua uacguauaut uauagauacg cguaaauuua uagcggcgcg cgcgutuuuu 420
attggcggga ggaggaaggc ggggucgguc gauuuaaaau aaauaauutg cguuagcgau 480
tttgucgucg cgutguagtg tgguutucgu utggtgcgcg uucgttgggg agutggggaa 540
utggggaguc guuauuauut cgguuauutc gttuuuuuau uuuttgucgt ucgcgutuag 600
guuucguuuu cgcggagucg ucguagggtt atattggguc gguucgaagg tggaggcgag 660
acguagucgc gguagguuag cggggagatg utguuucgga ggutgggagc gggaaggcgg 720
utgcgggcgu agcgguutcg gggautcguu tucgcgggtg utuaaggutg aaggcgucgg 780
auuttuuuuu acggtgguac guauatuatu cgguauuatt tucgtguuuc gaagacguuc 840
gcgcgggauu tgggaucguu agtgaagaau uuutuutggg ututttaacg aguaguagat 900
gcguatgutg uttututucg guaggaaagu uttutaaguu cggcgtgutc ggguauucga 960
gggtggaauc gcgguuuutg uauauautua uuuuaaagtu tuaacgtcga aucgaaggcg 1020
auauuuauuu aautuutuuu tutucguuuu atagtuuauu uaauauttgu aguuuutuua 1080
gagaaaaagu uuagcggaag aggautucgg aaaagtgaut atutcggaag auuagggtag 1140
agutuucggg agaaaaaggc gaagatuuuc gguuucggat cguuatuuuu ttuuutggua 1200
<210>168
<211>1200
<212>DNA
<213>智人
<400>168
gutuucgaaa gaggtuautg uaagtgtuut gcguaatttu tgttuaguau ututguagtg 60
acgauagggg tttgutttcg taaguaguat cgttttuaut autauagaag uauatacguc 120
gcgtguagut tagguucgag uaaagtuuut gutuuuutag auuuagtuuu ttuaggtgtu 180
uuuutagggg aautgtggcg tgtuuuuuua auuaggcgua utcguutaaa utgcgtuuuc 240
gaautuuagg gcguagggag uuutcgcggg utguucgggg utgggguuua uauutgaacg 300
gaggagucgg utggcggagc gguuucgcgc gcguauauac guauautuau agauacgcgu 360
aaauuuauag cggcgcgcgc gutuuuuatt ggcgggagga ggaaggcggg gucggucgau 420
uuaaaauaaa uaauutgcgu uagcgauttt gucgucgcgu tguagtgtgg uutucguutg 480
gtgcgcguuc gttggggagu tggggaautg gggagucguu auuauutcgg uuauutcgtt 540
uuuuuauuuu ttgucgtucg cgutuagguu ucguuuucgc ggagucgucg uagggttata 600
ttgggucggu ucgaaggtgg aggcgagacg uagucgcggu agguuagcgg ggagatgutg 660
uuucggaggu tgggagcggg aaggcggutg cgggcguagc gguutcgggg autcguutuc 720
gcgggtgutu aaggutgaag gcgucggauu ttuuuuuacg gtgguacgua uatuatucgg 780
uauuatttuc gtguuucgaa gacguucgcg cgggauutgg gaucguuagt gaagaauuuu 840
tuutgggutu tttaacgagu aguagatgcg uatgutgutt ututucggua ggaaaguutt 900
utaaguucgg cgtgutcggg uauucgaggg tggaaucgcg guuuutguau auautuauuu 960
uaaagtutua acgtcgaauc gaaggcgaua uuuauuuaau tuutuuutut ucguuuuata 1020
gtuuauuuaa uauttguagu uuutuuagag aaaaaguuua gcggaagagg autucggaaa 1080
agtgautatu tcggaagauu agggtagagu tuucgggaga aaaaggcgaa gatuuucggu 1140
uucggatcgu uatuuuuttu uutgguauua guttututag gutgcgcgaa ggaagagggt 1200
<210>169
<211>1200
<212>DNA
<213>智人
<400>169
gggautaata gatttattuu aggtgatagt gggaaguagu tauagaagga ggattggaag 60
gutgaggggt tgttaaagtt atutgatgat attgttcgaa uatttutucg guauagaaau 120
tuuauaaaga autuututgu agttttcgut auuuagggut gtttutttaa attgtttgac 180
gtuagagaag gaatgutata guaauagtut gtuaaautgg aattaautua gaagaaaaat 240
gggggtgggg agaggaaaaa tgutuuuagg cggtautgau ttuagaggaa guaaattgga 300
tagatguatt tattttatga uattttaaau ataaaauauu uagataaatg tgaaaaaaaa 360
aaaaautcga ttgagatgua tgtggtgttt aautuatgua gagaagagcg auttgguagg 420
gatatutgga agguuttuua gttttatuaa tgauaatagg aauaataaut tuuaagtatt 480
gguuatttat ttggagguag guttcgtgua aauatuautt uatttaatat guttaguauu 540
tttatgaggu aggtatuagt atutttattt tggcgatgac gaaauttagg uucgagacgg 600
tauacggtuu tauaautagt gatggaagag cggggautgu aacguaaggt tgtguaautu 660
tggguttuag tttautttut gauatttaga attuuagaat gggaaauuta aatgggguut 720
ttggggtutt utagututgu uuttcgatuu tgutaauaag uaaautggcg uutgtuagcg 780
ucggaaagga aautgguuac guuauttaga cgggcgutau ttaguagcgt guuucggcgu 840
uauauuaaua agaaaacgaa autguucggg aatgaatgtt tttuttutuu ttutgguagg 900
aaacgagaga gaaaatagga aguagaagut gcgcgcggcg uucgutuuut tcguuuuucg 960
uucgggutgc gcgcgutucg agggtutgcg cgtuuucggu acgtuuucgu cggguucgcg 1020
cguutcgtgu utcgcguutc gcguutuuag uuacgtuuuc guuucggutu cggcgcgucg 1080
cggagttggu tgutgggagg tgcgggautg ggtgtggucg gcggututgg tutcggutgt 1140
gagutgcgut utuuacgucg gutucgcgut uuaggggutg utgagcguuu agcggauauu 1200
<210>170
<211>1200
<212>DNA
<213>智人
<400>170
gtaauuagga atgatttgau tgtataaatt tatuttauag auauauttgt ttgtauattt 60
aatguutgut ttutataata tgaaaaaata uauagaacgt tttatguaat tggututgag 120
taatguaaua uataaatgut ttgagaguag ttauuaaaaa ttatguaggt tattauaaaa 180
gttatatgga attguauaga tattutaaat gtguttttga gtaaatttut uagutauuag 240
agguutgggu agutgtttuu aguauatuut gguauaauat tuatgttatu atuuauttat 300
gtattuuaua atttuaaatg attgataaga uauutuuuuu atutttgutt uututtggag 360
gaaaaaaata tauaaguaat uacgaguaua ggaguaggtg gauaautaua tuttaggaaa 420
gggtgcgtaa utgtgaautu taaacgtgag utgggtguut gatguagtat aggaauuaua 480
gtaagtcgat aatuagtgag gutggaggat tgaaatttta tttggtaaag aatattgagu 540
uaggcgcggt ggutuatguu tgtaatuuua guautttggg aagucgaggc ggguagatua 600
uaaggtuagg agatcgagau uaguutgguu aauatagtga aauutguutu tautaaaaat 660
auaaaaaatt agucggguat ggtggcgggu auutgtaatt uuagutautu aggaggutga 720
gguaggagaa tgguttgaau utgggaggtg gaagttguag tgagutgaga tcgtguuatt 780
guautuuagu utgggagaua gtgtgagaut uuatutuaaa aaaaaaaaat gaatattgaa 840
atagagtuta taggaaaaaa autuuttgaa tutagtaaat gtggaatuau aaaattgaaa 900
taatgtguat utgaaaagtg aataaataga tguuaagaag gagtgagtua taaguauatg 960
agttgtaaga ggttgaautt gagagauuag atuagguagt gucguttaat auuatuauat 1020
gatuutuuuc gagguuutgt atttaattaa aatagagagg gagguauuau agatguuaga 1080
agaauautgt tgututtggt ggacggguuu agaggaattu agagttaaau uttgagtguu 1140
tgcgtucgtg agaattuagu atggaatgtu tutautattt uutgggattt utgutuutgg 1200
<210>171
<211>1200
<212>DNA
<213>智人
<400>171
tuutauutuu utgguuautu uttttuagau tuutttgutg gtttgututu atttttuuut 60
aauutttaua tgttgatatg uuagaguauu tuaaauuutt agauutuatu tutgutautc 120
gtgutuuuat ggtgatutua tutagtutut ggtttuaaau auagagtgat uautuutgta 180
uttgutgttt uuuttttuut ggagttutut utguutuutg uaggtaggaa gtgattcgag 240
ataagagagg gagagaautu ttutgguuag gatagagggt gattutgaga agguttuaag 300
gaagaagtga guatttgagu acggutautt gaggaaggut agguuatgga uattagggtg 360
uagguaggag uagaguaaau atguttgtaa aaggaauagu aattattutg ttttatattt 420
atatuaguuu atggtgguuu uuauaguaga gtgguttgat ututuauutu uttuaggtut 480
ttgtttaaag attaauttut uuatgagguu ttutatgaau ataauuttta aaaauataaa 540
tuuuuttuut autgggautu uuuuagttuu uauuutgaga uuuuutatut ututtutcga 600
ttttatttut utuuatagga tgtgtatuau uauutgautt autagutatt tautatatat 660
tagtttattt uttuuuuatt agaatgtaaa uttuutgagg guagggattt tgtutgttga 720
gttuagttut gtatuuuuag uauutaaaau agtguutgtu uataauaggu atgttaaaua 780
ttgttggaua gatgaatgag tgaatgaaaa atggtagtau utttuutuut uuagtuuatu 840
utauauaaag agguaagatt aatttuuuta aatgcgtgag uattaggaag tgggagggat 900
tggaggagga aattataata aggaatuuat aaattautta aguuuataaa auaaaggtag 960
gaaauattua agataagaga uututtutgg uuaggataga ggttggttut gagaaggutt 1020
uaaggaatag guagauattt uaguaaggut gutgaggaag gataggutgt ggaaattagg 1080
atguaggtag gaggatuaua gaguaaauau tuuaaggtgg gaaatguaag tgtgtgtaga 1140
aggaauagua agtattgttg ggttgggutg guttatgaag ttgtgacggg utgagggaga 1200
<210>172
<211>1200
<212>DNA
<213>智人
<400>172
tgtgtatuau uauutgautt autagutatt tautatatat tagtttattt uttuuuuatt 60
agaatgtaaa uttuutgagg guagggattt tgtutgttga gttuagttut gtatuuuuag 120
uauutaaaau agtguutgtu uataauaggu atgttaaaua ttgttggaua gatgaatgag 180
tgaatgaaaa atggtagtau utttuutuut uuagtuuatu utauauaaag agguaagatt 240
aatttuuuta aatgcgtgag uattaggaag tgggagggat tggaggagga aattataata 300
aggaatuuat aaattautta aguuuataaa auaaaggtag gaaauattua agataagaga 360
uututtutgg uuaggataga ggttggttut gagaaggutt uaaggaatag guagauattt 420
uaguaaggut gutgaggaag gataggutgt ggaaattagg atguaggtag gaggatuaua 480
gaguaaauau tuuaaggtgg gaaatguaag tgtgtgtaga aggaauagua agtattgttg 540
ggttgggutg guttatgaag ttgtgacggg utgagggaga gauaggautg gaaaaguacg 600
ttggggtuag gttguagagg tuuttgautg auagagaggg gaguttggtu tgtggggaat 660
uttutgutut gtgtggtuag aggutggtut gaututucgg uuttguuuua gtuttuutat 720
uuttuatuua guuucggutg gutcggtaaa aacggcgcga atutcgutut uuutgggtaa 780
utagggtuuu uautguutgg utagtggtgu ttttcgcgtu ttuautggua uuattaatga 840
atgaagtutg gutuuuauuc gcggggaagg gaggaguutu aauutcgggt uutttgutut 900
uutguaguau tuutguucgg gtuucguutc ggggtcguua gguuutgaau uuuaacgucg 960
guattagtcg cguutgcgua cgguuutgtg gagucgcgga gguaagggac ggagaacggg 1020
gcggaggcgg agtuagggcg uucgcgcgtg gguuucguuu uuttatgtcg ggtataaagu 1080
uuutuucgut uauagtttuu utagtuutcg aaggutcgga aguucgtuau uatgtcgtgc 1140
gagtcgtuta tggttutcgg gtautgggat attcgtgggg tgagtgucgt utuaacggta 1200
<210>173
<211>1200
<212>DNA
<213>智人
<400>173
autgauautt tuattuatat gtttagaaga gauatatutg aagaaaattu tttttaaaat 60
agtttutuag utgagattat auttttttag tgtgtagutu auaggaagtt utagttguua 120
agaguatgtt cgatatgagt agatututau utaattutta tguataatga auuuaatttt 180
uatututtut agaaagatau tgaaaauatg tgtcgtgatu tuaatgttau aauuatgtag 240
uutuatuttt uauaatacgg tauaatuauu aacgaagttt aaauttuatg tutgguatuu 300
aaggtgaaua tttuuataga aagtaggaaa tatttagatg tutgtttguc gtggtggtgg 360
tgttuutata tautttttgt gauuutaaag atataataat gtttgauatt tttgttaguu 420
agtaatgtgg auttaagaua tuutaauuau autgutgaut utaauuuttt aatagauttt 480
uacgtagttu ttgaguutua utguaggutu uagtgutagt uucggaggaa atuagaaaag 540
ggttgaaauu autgauauag uuatututtt agutuutuut aacguaggtg tauagtttuu 600
tgtagtgagu agatcggggu utauagggau autguatgut tguautgggu tgttautagt 660
ttuatggaaa tatgtautaa ttgtgtuaut gtgttttutt gtuauautgu uuuutttuta 720
ggucgututg guaucgttta tttaaautgt guaauuatut gguuuaggtg ucgtagagat 780
tgatuagtag uauaagguua uuauaaguau aaucguuauu cgguuatuuu agutatttuu 840
tuuaguattu tagauatuat ggcgtucgag ggtgggtuua acggguttcg agtgttcggg 900
agataatgua uauttcguag tggatuttut cgggguuucg agcgttguuc guuuattagg 960
tggcgucggt uuuutcgaau aggtcgutua auaautuucg uuuaguaguc guuuttautg 1020
cgcgcgcgua gauttcggcg tutauttucg gtgtgguuua ggcggggtuc guagaauuag 1080
utatgtcggu utacgguatg uuuatgtaua agagcgggga uutggtgttt guuaagttaa 1140
agggutatgu uuautggucg gcgaggatag aguauatgau uuaguuuaau cgutauuagg 1200
<210>174
<211>1200
<212>DNA
<213>智人
<400>174
tttttagtgt gtagutuaua ggaagttuta gttguuaaga guatgttcga tatgagtaga 60
tututauuta attuttatgu ataatgaauu uaattttuat ututtutaga aagatautga 120
aaauatgtgt cgtgatutua atgttauaau uatgtaguut uatutttuau aatacggtau 180
aatuauuaac gaagtttaaa uttuatgtut gguatuuaag gtgaauattt uuatagaaag 240
taggaaatat ttagatgtut gtttgucgtg gtggtggtgt tuutatatau tttttgtgau 300
uutaaagata taataatgtt tgauattttt gttaguuagt aatgtggaut taagauatuu 360
taauuauaut gutgaututa auuutttaat agautttuac gtagttuttg aguutuautg 420
uaggutuuag tgutagtuuc ggaggaaatu agaaaagggt tgaaauuaut gauauaguua 480
tututttagu tuutuutaac guaggtgtau agtttuutgt agtgaguaga tcgggguuta 540
uagggauaut guatguttgu autgggutgt tautagtttu atggaaatat gtautaattg 600
tgtuautgtg ttttuttgtu auautguuuu utttutaggu cgututggua ucgtttattt 660
aaautgtgua auuatutggu uuaggtgucg tagagattga tuagtaguau aagguuauua 720
uaaguauaau cguuauucgg uuatuuuagu tatttuutuu aguattutag auatuatggc 780
gtucgagggt gggtuuaacg gguttcgagt gttcgggaga taatguauau ttcguagtgg 840
atuttutcgg gguuucgagc gttguucguu uattaggtgg cgucggtuuu utcgaauagg 900
tcgutuaaua autuucguuu aguagucguu uttautgcgc gcgcguagau ttcggcgtut 960
auttucggtg tgguuuaggc ggggtucgua gaauuaguta tgtcgguuta cgguatguuu 1020
atgtauaaga gcggggauut ggtgtttguu aagttaaagg gutatguuua utggucggcg 1080
aggatagagu auatgauuua guuuaaucgu tauuaggtgt ttttuttcgg gauuuacgag 1140
acgguuttuu tgagtuuuaa acguutgttu ucgtauaagg agtguaagga gaagttcggu 1200
<210>175
<211>1200
<212>DNA
<213>智人
<400>175
aaagguaaat tatgtguaua tgauuutgtu autauaaggt agttutcgau uaagutauat 60
uttatagutt tatuttatat tuututuuua tuatutguag gaaaagggat aggtgutgag 120
ggaaaauuuu taagtagaau tuauagtaag uagtgggaaa auaguttatt tuautaacgg 180
ggttaagtgg uuutgaaaag aguutttgga gauaaaguag ucggcgauuc gcggagggag 240
ggagggaggg agcgagcgag cguuaggtuu cgguagggau tuauttggag utggcgtaut 300
tggtgaucgu uttggtguuu tcggauacgg cgtguttggu uagutcgucg gguaguagua 360
ggcguacggu cgtutggatu tucgggacgt gatggtggag cguttgttgt agtgcguuag 420
gcgggacguu tutuucgcga tgcgutcgaa gatgtcgttg aggaaggagt tuatgatguu 480
uatgguuttg uauuagatgu cggtgtcggg gtggauucgu ttuaguauut tgtauacgta 540
gatggagtag ututuuttgc ggutgcgutt gcguttuttg ucgtutttut tutggguttt 600
ggtgacggut ttuttggagu uuttuttggg agucggcgcg aautttguag gutuagguat 660
gguuagauuu aagaucgaua ucgauuuucg agaacguaag uagagcggta ggutcggggt 720
utaucggaaa cgautgtgta uttauagagg utgtgcguat gacgutgcgt tatggttcgc 780
gagttttucg cggcgcguaa tgcgagggag acgagattat gtaaatgagt ggattutggu 840
tgagutatuu tattggutat cgggauaaaa tttguttgag uuaatuaaag tgutucgtgg 900
auaatcgucg ttutgtutat aaaaaggtga aguagcggcg ttttcggcga utttuucgat 960
cguuagguag gagtttutut cggtgautau tatcgutgtu atgtutggtc gtgguaagua 1020
aggagguaag guucgcguua agguuaagtc gcgutcgtuu cgcgutgguu ttuagttuuc 1080
ggtagggcga gtguatcgut tgutgcguaa agguaautac gcggagcgag tgggggucgg 1140
cgcguucgtu tauatggutg cggtuutcga gtatutgauc gucgagatuu tggagutggu 1200
<210>176
<211>1200
<212>DNA
<213>智人
<400>176
utatataaau uaaaaattgu ttuaauuaua gaatggaggt utauaggtgc ggaaggaaag 60
tttatatggt gagguttggt cguaaaauta ttaggaatat tttuaggtta utauauaatt 120
ttgcgagutu aatatguagt taauautttt tuuutcgaut utuutgagua gatttauatt 180
gaucguauuc gtaguatatc gtutuauttt ggaaaaggua aattatgtgu auatgauuut 240
gtuautauaa ggtagttutc gauuaaguta uatuttatag utttatutta tattuututu 300
uuatuatutg uaggaaaagg gataggtgut gagggaaaau uuutaagtag aautuauagt 360
aaguagtggg aaaauagutt atttuautaa cggggttaag tgguuutgaa aagaguuttt 420
ggagauaaag uagucggcga uucgcggagg gagggaggga gggagcgagc gagcguuagg 480
tuucgguagg gautuauttg gagutggcgt auttggtgau cguuttggtg uuutcggaua 540
cggcgtgutt gguuagutcg ucggguagua guaggcguac ggucgtutgg atutucggga 600
cgtgatggtg gagcguttgt tgtagtgcgu uaggcgggac guututuucg cgatgcgutc 660
gaagatgtcg ttgaggaagg agttuatgat guuuatgguu ttguauuaga tgucggtgtc 720
ggggtggauu cguttuagua uuttgtauac gtagatggag tagututuut tgcggutgcg 780
uttgcguttu ttgucgtutt tuttutgggu tttggtgacg gutttuttgg aguuuttutt 840
gggagucggc gcgaautttg uaggutuagg uatgguuaga uuuaagaucg auaucgauuu 900
ucgagaacgu aaguagagcg gtaggutcgg ggtutaucgg aaacgautgt gtauttauag 960
aggutgtgcg uatgacgutg cgttatggtt cgcgagtttt ucgcggcgcg uaatgcgagg 1020
gagacgagat tatgtaaatg agtggattut ggutgaguta tuutattggu tatcgggaua 1080
aaatttgutt gaguuaatua aagtgutucg tggauaatcg ucgttutgtu tataaaaagg 1140
tgaaguagcg gcgttttcgg cgautttuuc gatcguuagg uaggagtttu tutcggtgau 1200
<210>177
<211>1200
<212>DNA
<213>智人
<400>177
gatggaguag aagututaat tguttcgagg tauaagtuua tutaaauutu tgagatutua 60
uucgtuuucg gtaaguuutt gcguuutuua gauaagutuu tuagtgaaag uaagcgucgu 120
aucggtguut gtguuagtut uuuagaaagg aguataagga gtgttuuauu auuaututgg 180
attutttatt uuaauaauuu agucggaggg gaaaatutgu taaauuauuu uauaagguag 240
aaautttatu aaaatutggu autauaauau tgguuutuat uacgucguua uaaattgcga 300
gggatagaag aaagutguaa agtuacgtta aaaggaaguu tagtuaaaaa gtgaaaattt 360
tgtuucguuu tagguauaua guautuauag uataagatgt agttuuatga gtuutaggaa 420
agggggaaga aaggaaaaaa uuaaauatut gututaggtt tagaagaggg ataauatuag 480
cguuaaguaa aucgaaagcg uagaggautu agaagagggg aagaggaata autttatutg 540
tuutggaggt gggcgaagag uagtutuuau cggucgcgcg tuacgutuuu atttaauutt 600
ttuuatgucg cgacguuuau autucguuut cgagggauta guuuuuuuua cgatuuagag 660
uagaagcggu tcguuucgut guatuuacgg guuutuauuu aagcgtuuag tuutguuttt 720
utuuuuuuau utcguuuaat auutgtucga gaguaggcgt tutguuutut cguuucguuu 780
ttguuuaggu aguuuucggt cgcgacggut utuutcgggg utcgggggcg utgggcggcg 840
guuutgggut gutttgguta auttggutgc gggguaggcg cgaggagcgg cgcgucgauc 900
gggucgagcg gagaggucgu uuattggucg guuagcguua cgtggucguu uucgucggta 960
tattagguua utatttauut ucggutuaut cguuatgggt tggagagggu agutcgggta 1020
gagagggutg gcggagcggc guagacggcg guagtuutgu tuaguututg uucggutucg 1080
tautucgguu ucgguutgcg uuutuagaaa ggtgggguuc gaauuatgag utuutauutg 1140
gagtacgtgt uatguaguag uagcggcggg gtcggcggcg acgtgutuag uttgguauuu 1200
<210>178
<211>1200
<212>DNA
<213>智人
<400>178
guutgtguua gtutuuuaga aaggaguata aggagtgttu uauuauuaut utggattutt 60
tattuuaaua auuuagucgg aggggaaaat utgutaaauu auuuuauaag guagaaautt 120
tatuaaaatu tgguautaua auautgguuu tuatuacguc guuauaaatt gcgagggata 180
gaagaaagut guaaagtuac gttaaaagga aguutagtua aaaagtgaaa attttgtuuc 240
guuutaggua uauaguautu auaguataag atgtagttuu atgagtuuta ggaaaggggg 300
aagaaaggaa aaaauuaaau atutgututa ggtttagaag agggataaua tuagcguuaa 360
guaaaucgaa agcguagagg autuagaaga ggggaagagg aataauttta tutgtuutgg 420
aggtgggcga agaguagtut uuaucggucg cgcgtuacgu tuuuatttaa uuttttuuat 480
gucgcgacgu uuauautucg uuutcgaggg autaguuuuu uuuacgatuu agaguagaag 540
cggutcguuu cgutguatuu acggguuutu auuuaagcgt uuagtuutgu utttutuuuu 600
uuauutcguu uaatauutgt ucgagaguag gcgttutguu ututcguuuc guuuttguuu 660
agguaguuuu cggtcgcgac ggututuutc ggggutcggg ggcgutgggc ggcgguuutg 720
ggutgutttg gutaauttgg utgcggggua ggcgcgagga gcggcgcguc gaucgggucg 780
agcggagagg ucguuuattg gucgguuagc guuacgtggu cguuuucguc ggtatattag 840
guuautattt auutucggut uautcguuat gggttggaga ggguagutcg ggtagagagg 900
gutggcggag cggcguagac ggcgguagtu utgutuaguu tutguucggu tucgtautuc 960
gguuucgguu tgcguuutua gaaaggtggg guucgaauua tgagutuuta uutggagtac 1020
gtgtuatgua guaguagcgg cggggtcggc ggcgacgtgu tuaguttggu auuuaagttu 1080
tgucgutucg acguucgguu cgtggututg uaguucguut tuuututggg uaacggcgac 1140
ggcguuttcg tuagutgtut guuuutgguc gucguucgau uutcguuttc guuuucgguu 1200
<210>179
<211>1200
<212>DNA
<213>智人
<400>179
aauagtgtga aaagtuauat gataaautgg ggaagatattt auagtauat gtaatggaua 60
gagggttaat gttuttguta gatatuttaa aatuaagaaa aataaautua gtaaaaagat 120
guaaagggua taagatggaa ttuauauaua gtguaagttg aatttttttt tttttttttt 180
guutguuaga gtgutauagg taaaauagat tgutautauu uagtgttgut ggtgggutag 240
agtgttuatg tagutttutg uagguuagtu tgagaatatt tattaggatt ttaaaagtgu 300
attuattgau uaguauttua uttutgaatt taatguaagg aaatagttgg gtaaatgggu 360
aaaautattt tgtauaaaaa tattuattgt gttuataata guaaaaaatt ggaaatuatu 420
uaaatgtuat ttgtgttata autuuataua utggaaaagt gaguaguuat gaagatggtg 480
tagatttgtt tuauuaguat ggaaaggtgu utgttauata tttaagtgtg aagatgaggt 540
tgtaaaatgt atguutggta tgutatgatt tuataagaua cgtggaauta tatuttutta 600
tatgucgatt gatgaagatg gaatuagtgt atatauuaaa gagattaaaa gtggttuttt 660
atutgagtga tgattttgtu ttuattgtgt ttagaataut aagaagtttu aguagtggaa 720
tguutautut tuttataauc ggagtggaaa cggaaguatt ttgtgagagg gutggaggga 780
aggtgagaac gggcgttggg agguuuttuc gtggutuuag guutagggut gcggaauuua 840
uaauagaauu cguaaucgua aucgggaauu cgagtguutg uutagutggg gggucggagg 900
gagggcgggg aggguagcgu uacggauuuu agcggaucgg aaggguttgt gguacgcgga 960
atuuuuutua gagguuuuua gutguuttuu utgtgguatu atgaagtttc gcguuaagat 1020
uaucgguaaa ggutgtutag agutgttuat tuacgtuagc gguaucgtcg cgaggutagc 1080
gaaggtutgc gtgutucgcg tgcguuutga uaguutgtgu ttcgguuucg cgggttucgg 1140
cgguutuuac gagguuaggu tgtggtgcga ggtgcgguag gggguuttuu aguagtttcg 1200
<210>180
<211>1200
<212>DNA
<213>智人
<400>180
gguuaaguaa auauucgutu atatttagtg uatgaguutg ggttcgagtt gucggaguut 60
cgcgcgtagg guaggggttc gagcguuuut tutuuutguu tcguututgc guutgggggu 120
tgutguutua gtttuuuagc gauagguagg gatttcgagc gtuuuuutuu uutuuutcgt 180
uaagatuuaa gutagutguu tuagtttuuu cgcggaguut gggacguuag cggaggggut 240
cggcgcgtag ggatuacgua guttuuttuu tttttutggg agutgtaaag acguutucgc 300
gguuaagguc gaaaggggaa gcgaggaggu cgucggggtg agtguuutcg ggtgtagaga 360
gaggacgucg atttuuucgg acgtggtgag aucgcguttc gtuautuuua cggttagcgg 420
tcgucgggag gtguutggut utgututggu cguttutcga gaaatguucg tgtuagutag 480
gtgtggacgt gauutagggg gagggguatu uutuagtgga gggaguucgg ggaggattuu 540
tggguuuuua uuuagguagg gggutuatuu autcgattaa agagguutgc gtaagutgga 600
gagggaggau ttgagttcgg auuuuutcgu aguutggagt utuagtttau cgutttgtga 660
aatggauaua ataauagtut uuaututucg gggaagttgg uagtatttaa aagtauttaa 720
taaaucgutt agcgcggtgt agaucgtgat tuaaguttag uutggucggg aaacgggagg 780
cgtggagguc gggaguaguu uucggggtua tcguuutguu aucgucguuc gattguttta 840
guttggaaat tucggagutg aagcgguuag cgagggagga tgauuututc gguucgggua 900
uuutgtuagt ucggaaataa utguaguatt tgttucggag gggaaggcgc gaggtttucg 960
ggaaaguagu aucguuuutt gguuuuuagg tggutagcgu tataaaggat uacgcguuuu 1020
agtcgacgut gagutuutut gutautuaga gttguaauut uaguutcgut atggutuuua 1080
guaguuuucg guucgcgutg uucguautuu tggtuutgut cggggututg ttuuuaggtg 1140
agtcggggtg gggattgucg tcggguuagt tutucgaagu uucgggagga ucggutuucg 1200
<210>181
<211>1200
<212>DNA
<213>智人
<400>181
gggagggtuu uacggauata ttgagggacg tggatacgua gaagaggtat uuatgtggtg 60
guagucggga aggggtgatu agatggtuua uagggaatat uauaaautcg aattutgacg 120
atgttutggt agtuauuuag uuagatgagc guatggagtt gggggtgggg ggtgtuaaag 180
uttgggguuc ggaagcggag tuaaaaguat uauuutcggt uuuttgttut cgcgtggatg 240
tuaggguuuu uauuuaucga guagaaggcg gautuagggg cgutuuaggg tggutcgagu 300
tuauauacgu tgagtagaua cgtguucgut guauuutggg taaatauaga uucggagucg 360
agcggattut aatttagacg uucgcgaacg utgcgcguac guauacgtgt uutcggutcg 420
utgguauttt cgtuucguuu uutucgtcgc gtgcgggagu tgauucggag gggtguttag 480
aggtatggut ucgcggggtu aaaaggagaa ggatuagtga gagagguatu uuuauauuut 540
uuuutagaau tgtuutttuu uuatuuagtg uutuuuaaat utututtagt uuuuaaatgt 600
atuuucguuu taaggggcgu tggtgggagg agutaaatgt gggggcgggg utcggagtuu 660
aguttattat uatgguatut uaguuagggu tggggtaggg gtttgggaag gguaauuuag 720
uatuuuucga tuuuagagtc gcggucgggg atgacgcgag agagcgtggt cguuuuuaga 780
agguuutggg uuatuatguc gguutuuacg tagauuuuag gggtcgutua utuutguuag 840
utcguuttua uuaagguuag gaguttagcg uacgutcguu tuucguuuuu ucgucguutu 900
tgucgucguu uuutuuttgg aaauuaagtt auuaacgtta aauuaatuuu uaagcguaau 960
tutguutuuu uuauauuuua uucgucgcgu cgcgcggagu cgtuututag uuuagutuut 1020
cggutcgcgu tutuutcguu tuutgtgutt tuuucgucgc ggcgatguua ggguuttcgu 1080
uagggutgcg ucgggcguta utcgguutut gggutgutut ggguutgggg ututtcgguu 1140
tutuaggtaa gaguuucgut utggttcggg gtggauaggg cgggggcgga gtuuutggau 1200
<210>182
<211>1200
<212>DNA
<213>智人
<400>182
ggaaagggga tcggggagga aagtcgggga ggcgaggtgg gggcggtggg utgagcggga 60
auttaaaaga ucgcggtgga gaagatgggg cgttutucgc gauautcggu tguuuagagg 120
tguaaagucg gtgggcguac guucggggcg guuutauagu uutcgggucg uuagtutuag 180
ggtgtcgggu tuuaautaag guuucgaagu uuuuacguau utgaggguat tttgauuagu 240
tuttgcgggu tgtuttgcgg ucguagtggg ttutgaaagt uuattucggc gtagggtgga 300
aaucggcggg aggcgttgut gattutcgat taaauaatag tgacgagacg cgtgcggggc 360
guutgcgagu uuuttuutgu uautcggagu agagcgcguu agcgcgaggu cgggucgguc 420
guutgcguag cgucggguta attttaautg ttgattauat uttuagcgtg tuutttuata 480
ggtutuattt gtaattgaga cgaatgatta uagtggggcg ggaaggagua gutgutuatt 540
aattaatttu taattaaaag tguututcgt tutcgggtga utaaagagaa auaucgttcg 600
utgggcgata ttgautcgga tggaatttat ttgutaacgu ucggaggaat gguuuutucg 660
tuuaucgcgc ggucgggaut gtuutgguuu utuucgguut gagucgucgg cgagtgaucg 720
gcgagtutgc gguuaggucg ggutgcgcga ggtggggutg acgtuagagu utuutucgut 780
tuaagucgcg uauatutgau ttgacgggtt cgcgcgautc gttttttttt ttttuttttt 840
cgtaaaatat gtatttutgt cgucgutgcg aggucgutcg gtuuuagagu uuuutcgagu 900
utucggaatg cgaagttaaa ggaatcgcgg cgguuaucgu tgutuauttt gttauucggt 960
tagaaaagtt tgcggagcgc ggggatggau taaucggutu tuutguttcg uuutuuuagc 1020
guutagaagu utguagutuc ggaguagtgg ucgcguuacg ucgguuuuag cgcguagaau 1080
uutguagguu ucguucgtuc guuucggguc gcguucguua tgtuutauuc guagtttgga 1140
tauuuutaut uutcggutuu uuaggtaagc ggaguuucgu uucguuuagg uuaucguagg 1200
<210>183
<211>1200
<212>DNA
<213>智人
<400>183
gaatuatagt aggtaattga gttatttttt aatttttatt utgtutttat aagatttttg 60
agaaggtaat uaattaauat aaagatutga guagttataa agatttauaa agaagattat 120
auagtgatgg aaautgaagu atattuttgg uaauaatutu aatutatttu acgtttuucg 180
guttttauat atataaattt ggtatauata atatgtaaat atauttutat tttguatgaa 240
aautaaaaat autaaaaaag taguatgagt atatgaaaaa gttaaauatt aaaaatatta 300
gttggaaaut gguttatttt autaauaatt atattuagaa ttutgttgut agautgutgt 360
ttutgggaau attggaggtg tautttutat auttgutaaa atauaagutt ttuaagtatt 420
ttuuatagta ttaagtgaga utttaaatau tuttgutttt ttagatutaa tttutguttt 480
aatttatuut tututtuatt tttuutgttt gtuutuatut tauutgttut tuuutggttt 540
tautatutuu uagtattuag aaatuagagu aaataattag tutguttttu tguagaataa 600
autattgggt atguuatuat guttttgatu tauuauataa auaaattatt ttaguaagau 660
atuautttta tatgutgtat aatgtatgta ttguttatgt tttaaguaga tttuagutut 720
tttuuttuua tuaatttgga attggggguu uaaaagatgt gaaggcgata atguttuuaa 780
gataautggg utguatuutt atttgtaaaa taagaaatau tttatttuuu aaattttaaa 840
ggagtgttuu ttutucgauu tgttgtgatg gatttattut atagutatgg aaatatauuu 900
tguttuautu ttgtauatau ttutttautu tuutuucguu aagttuattg aaagagaauu 960
uatgtgucgg tuuagaguat cgutguatuc gtaaguagut agauutuagu ttuututgtu 1020
auuatggtgu cggutcggut ggguucggcg gtcguuatgg taautggggc gggtcguagg 1080
gtuutgguag gutgggcgua tgcgcgcggg gautauaagu cgcgucgcgu tgucgutggu 1140
uuutuaguaa uuutcgauat ggcgutgagg cgguuaucgc gautucggut utgcgutcgg 1200
<210>184
<211>1200
<212>DNA
<213>智人
<400>184
taggggagag ggautcguua aatuuutgtt ttutggggta aguuuuuutu uuuuuautut 60
tggauuuaag utguucggaa ggaagaagga aguattgttt gtuaucggag aaaauuauut 120
gtggtttgua aaggguutua gtcgagtuag ggguaggcgg gguagatucg aguucggcgg 180
gaggggcgag gcgcgggggc ggguaggggc gagggtaggg gcgutuagut gguaggtuut 240
gututguagg uutuaucguu uagutuucgg gagggggucg agggcguuut gagtgutgcg 300
cguuttuuua tgacguagtt uutgtguutt taaatuuuau tuucggaggg ggcgggggcg 360
uuucggutgg auuucggttt uuagtucggc ggggguuucg gggaaguuua gggcggggag 420
cgcggggutg ggggcgcgga gggcggggcg uucggggtuu ucguucgcgc gucgcguuut 480
aguutgutgg gucgcguuuu tuttgggauc gucgcgutuc gggggcgggg gcgggggcgg 540
gggcgggggg cggggggcgg ggggcgggcg ggggcgcgcg ggcgggcggg gtgcgggcgc 600
gcgucgcgcg guucgagcgc gcgagucggg uucggagcgu acgucgucgu cguuaucguc 660
gucgucgucg uucgagucgu cguattgutg utgutgutgu cgucgucguu ucgcguucgg 720
uucgcgguuu uuaatatggt guagucguua gcgucgucgu ucgtgucguc gucgucguuc 780
gcggguuucg ucgucguuut cgggcguucg uagcgcggua gucguaggtg gggggucgcg 840
guucggguut gagutguuuu ucguucgguu tcggcgcggc guuutuuucg cggggutguc 900
ggcgaggggu uututcgucg utgaggtgga gucgcggguu ucgucgucgu cgutuutguu 960
uuutuuutuu utuutuuuut uuuuutuuuu tucggtuutg tutuuagcgg gagcgcgaga 1020
cgutggtuag gutucgcggc guagutcgaa aaggaataat cguuuucgat tgautgaaat 1080
tuutucggag ucggcgucgc ggucguucgc guucgagauc gcgutucggg gucgcgtuut 1140
uututuutuc ggaaaacgut cgcgauuuag ggucgucggc ggucgcgaut utgutgtgtu 1200
<210>185
<211>1200
<212>DNA
<213>智人
<400>185
utttututtt uatuttuutu uututguuag aguuagggag ggagagtggg aggcgtuaag 60
gaggtagggg agagautggu agaggaaaag gagtgggtgg gtggggguua agtaaataga 120
tauttagatg atgaagtuaa guuautgcgg uaatgtttut tgtuagtttu acgcggguaa 180
agcgtguutt tcggtgggtt ataaguagcg uucggtuutt uuttututcg uuaagttguu 240
tgatuuttuu utuuaggcgc gcgcguauau auuauautua uauauuuuaa aauuaagaut 300
cgtuutauag gatutgggaa aagaaaaaga aaaaaaaguu utuaatuauu auutuuttut 360
cgucgautuu uuutuauuuu ucguutuuuu tuuagcgggu aguuaaggag agutagaggc 420
gggggagggg agagggagga gaagcgacgu aagtgggtag uttttuagcg ucggcgaggc 480
gcgggaggag gagaaguagt ggggaggcgu agucgutuau utgcggggua gggcgcggag 540
gagggauucg ggutgcgcgu tutcgggucg aggaauuagg acgcguucgg aguutcguac 600
gcgguuaagu tcggggcgtu uuutuuuutc ggucgggcga autuaagggg cguagututt 660
tgutttgaua gagutggucg gcggaggcgt guagagcggc gagucggcga guuaggutga 720
gaaautcgag ucgggaauaa agaggggtcg gautgagtgt gtgtgtcggu tcgagutucg 780
gguagaggua tttggguucg agguuuucgu tgtgautuuu cgagautucg uagtguuutu 840
uautgcggag tuuucgcgut tgucgguaaa aautttattu ttgguaaaut tututttutu 900
ttuuuutuut uutcgguuuu uatuttutgu tuutuutuut tututaguag attaaatgag 960
uutcgagaag aaaaaucgaa gcgaaaggga agaaaataag aagatutaaa acggauatut 1020
uuagcgtggg tggutuuttt ttutttttut ttttttuuua uuuttuagga agtggacgtt 1080
tcgttatutt utgatuuttg uauuttuttt tgggguaaac gggguuuttu tguuuagatu 1140
uuutututtt tutcggaaaa uaaautauta agtcgguatu cggggtaaut auagtggaga 1200
<210>186
<211>1200
<212>DNA
<213>智人
<400>186
aatgagauuu agagggtcgg tuutaggaua uaattuutut uauuututgu ttutguuauu 60
atuutttuuu utttguuutt ggaggtgutg gaggaggtgg gagtgtuuuc gagagtgtuu 120
agautguata aggtgguaga aaggtgutga gtgtuttuua ttguauuagt gtuagggaut 180
tggatgtggt uuuuagguuu aaaguuaagg uagatggaut uatggagggg gaggaguaga 240
ggaguagtgc ggagtuautu tutuuatgta guauuuuuag utuagtguat tgutggggtt 300
uttguagggu agatgaagtg uttutttgta taggggaata tgtgggtgaa uuaggaaaat 360
gggaguutag tauatggagg tttattuuaa utuuutgtgt gattgguaag ttagaattgu 420
uuuuutauut gagttattat tggutuutga gaaauagguu aaagguaguu uuuautaaga 480
aguttttagu auutuutata ggaaggaagu uttuuuagtg aatuuagtgt gaggattutt 540
ttutuuaggt ututggauut utuuuaauat gutuuatgtt uutttguacg aagaagaaua 600
gcguagttcg gtagagtgta tgtaaguuuc ggttguuatu aguauautgt gtggattutg 660
guaatauutg tuatuuuuau tggtgutgcg gtguuuutua tguuuuttgt taataauuaa 720
tgatagtguu auttgaautu uuaggutgtt gtgaggagua aguattuatt uattuattua 780
ttuaatuaut uatttgttua tgtgauaaat gtggattgaa tguttguuut utttuututu 840
uuutggaguu ttggagagag agataagaua agcguaaata autgtgauut gttgtaggaa 900
gtgagaaata uauuuaggua ggguuagata utgcgtagua ggcgggguau agaggaggga 960
acguttgtgt utaautgatg utuutaatgc ggaaguuuut gaaaggcggt tgtggtguaa 1020
aggaaaauuu auagguuaag gaatgggaag auuaaggttg auauttgttt gtuaagtgtu 1080
aataatuatu tutguucggt gagttgttgu atgaaguaag atuutuuttg gggggtgttt 1140
aguauagagg gggtgcgatt ttatttuutg tgaaaatauu aggtagtatt atgttuauta 1200
<210>187
<211>1200
<212>DNA
<213>智人
<400>187
uatttuauut atttgautut guutguutag aguttgucga gaatgagauu uagagggtcg 60
gtuutaggau auaattuutu tuauuututg uttutguuau uatuutttuu uutttguuut 120
tggaggtgut ggaggaggtg ggagtgtuuu cgagagtgtu uagautguat aaggtgguag 180
aaaggtgutg agtgtuttuu attguauuag tgtuagggau ttggatgtgg tuuuuagguu 240
uaaaguuaag guagatggau tuatggaggg ggaggaguag aggaguagtg cggagtuaut 300
ututuuatgt aguauuuuua gutuagtgua ttgutggggt tuttguaggg uagatgaagt 360
guttutttgt ataggggaat atgtgggtga auuaggaaaa tgggaguuta gtauatggag 420
gtttattuua autuuutgtg tgattgguaa gttagaattg uuuuuutauu tgagttatta 480
ttggutuutg agaaauaggu uaaagguagu uuuuautaag aaguttttag uauutuutat 540
aggaaggaag uuttuuuagt gaatuuagtg tgaggattut tttutuuagg tututggauu 600
tutuuuaaua tgutuuatgt tuutttguac gaagaagaau agcguagttc ggtagagtgt 660
atgtaaguuu cggttguuat uaguauautg tgtggattut gguaatauut gtuatuuuua 720
utggtgutgc ggtguuuutu atguuuuttg ttaataauua atgatagtgu uauttgaaut 780
uuuaggutgt tgtgaggagu aaguattuat tuattuattu attuaatuau tuatttgttu 840
atgtgauaaa tgtggattga atguttguuu tutttuutut uuuutggagu uttggagaga 900
gagataagau aagcguaaat aautgtgauu tgttgtagga agtgagaaat auauuuaggu 960
aggguuagat autgcgtagu aggcggggua uagaggaggg aacguttgtg tutaautgat 1020
gutuutaatg cggaaguuuu tgaaaggcgg ttgtggtgua aaggaaaauu uauagguuaa 1080
ggaatgggaa gauuaaggtt gauauttgtt tgtuaagtgt uaataatuat ututguucgg 1140
tgagttgttg uatgaaguaa gatuutuutt ggggggtgtt taguauagag ggggtgcgat 1200
<210>188
<211>1200
<212>DNA
<213>智人
<400>188
uuauuatguu utttgututu uagggututg gggucgguuu aggtuaguua uttggtggga 60
ttuuaguutu agggtggutg agutguaggt guaguauucg guutuuaggt gguauuaatu 120
cguttauttt gaggtgggut utgauaauua gutgagutgu uuauagtuuu tuagautuuc 180
gaggtuutgg gaguagggat uaaggtggtu uuuaggucgt aaauutgaua gaggutguag 240
gagtguattt uuauuuaggg tguautuagc gggtgtaaut uuauauucgt ttutttggag 300
tuaagguucg guututuagt gaggagautg utuutggttg uuuaucgtcg ggtuatuuua 360
guutguagtg gaauuutucg uaguutgguu tuttuuaggg taguuuutua utuuuututu 420
tuutgtuuta guagauaggu uagggagggt ggacgagttu uagututggg gatgtuuuat 480
uagutgtgtu auuttgaaua aatuattttg uututtgggt utuagtttuu tguagtgtga 540
aacgtggtgg agguatgagg gguaatggga guuuuaaggu ututttuaga gauutuutut 600
gggtuuuatg tgauutcgtg gutgtuuuua aagguaagag ggtuuuuagu uutgcgguua 660
agguuutggg auauuutatu uaaauaaatg uaggtututg acgggutgag utttgutcgu 720
ttgggtttut ttgutttutt uutttttttt ttttutttuu tggatgaaat tuutguuagu 780
tucgaaggaa ggagggaaga ggagcgaguc guagtgtaga aagtttuutt gautuutuut 840
ucggutgggt utuuutuuut tguuaaguuu aguutgtgaa autgaataac gaagatuaut 900
uaauaatguu tguuuututu tgautguauc gtuucggcgu tuuuaucguc gucgucgucg 960
uuuaatagag uuuutggggc ggtuuuuauc gacggtguag uucgucggga ucgggaggaa 1020
guagutgcgg uuatcgcguc gtgcgtucgc guucggucgu uaggtguuuu agtaguucga 1080
ucgucgagat guuuaguucg ucggggutuc gggcgutatg gutttgcguc gcgutgtgcg 1140
uttuucggag ggucggcggc guuuuuuagu ucgguucggg guuuaucguu tguucgguuu 1200
<210>189
<211>1200
<212>DNA
<213>智人
<400>189
gutgaagtua uutttuuagu agtgtutggt uuaguuaggg uatuatguuu agtaauaguu 60
ucgatgtuua auauttuuuu atgtuututt utuuuuutag auautguuau uttaggggtu 120
utggutgtta uttcgtuuua ggguutgaut ggtagtutta gttauauaua uaauauaggg 180
gagggaggaa ggaguttggg guaaagggag ggagtuuagu uutttguutt tuuttggaga 240
agguaaggga gauaggaatg uutttggutg ggagauuutg guuagagatu agaagatuaa 300
aggatgagaa gatuaggggc gagguaggtg guautuautt ggagguauua gagagaagcg 360
guagutgutg uutuutaagg guagggutga uuuagaacgu uutuututau uuauaguutu 420
uuuaguutat utttuutaau tttataguuu tguttutuua uuaggagggg ututgttggt 480
tauatguagg tgaggagagg gatgtuuaut gauattuatg utauauuuat gggttutuuu 540
atttaaauut uauaauatta tuttatgggg aatattagat autattttat agatguagaa 600
autgagguau agagaggaaa ggaautagtu uaatatuaaa uaautgutaa gtgttagggu 660
uaagatauaa aututgguag tutgauuuua gaguuautga ggattauatt ataaggguag 720
guagagaaut utattuagtu uaautguagu atgagggagt gaggutaggt atuaggaagg 780
auttuttgtt ggguaggtat tttagatuua gatuttggat utagtutttu tatagututg 840
atgaauuaaa tagttcggga gttagggaag aggguagatg ggtggggcgu tatuuagagg 900
gaaggguata cgagagaagc gguagaacga gagaggatua gcgcggaggg tggcggguau 960
tggaucguag aautgguaut cgaggtuuua ggggucggaa tgcguttgga gggagagggu 1020
cgutuagcga gggcgggaua gaauututuu cgggutggga gtguacggcg cggtgcguuu 1080
aggtaggutt gggggaaggg tgucgagutu cggaaagttu uauaggtuut ucguaguuut 1140
ggggaguagg auuuagaaau cgacgcgacg ggtggggcgu tauucggguc gguuutaatu 1200
<210>190
<211>1200
<212>DNA
<213>智人
<400>190
tguaguauuc gguutuuagg tgguauuaat ucguttautt tgaggtgggu tutgauaauu 60
agutgagutg uuuauagtuu utuagautuu cgaggtuutg ggaguaggga tuaaggtggt 120
uuuuaggucg taaauutgau agaggutgua ggagtguatt tuuauuuagg gtguautuag 180
cgggtgtaau tuuauauucg tttutttgga gtuaagguuc gguututuag tgaggagaut 240
gutuutggtt guuuaucgtc gggtuatuuu aguutguagt ggaauuutuc guaguutggu 300
ututtuuagg gtaguuuutu autuuuutut utuutgtuut aguagauagg uuagggaggg 360
tggacgagtt uuagututgg ggatgtuuua tuagutgtgt uauuttgaau aaatuatttt 420
guututtggg tutuagtttu utguagtgtg aaacgtggtg gagguatgag ggguaatggg 480
aguuuuaagg uututttuag agauutuutu tgggtuuuat gtgauutcgt ggutgtuuuu 540
aaagguaaga gggtuuuuag uuutgcgguu aagguuutgg gauauuutat uuaaauaaat 600
guaggtutut gacgggutga gutttgutcg uttgggtttu tttgutttut tuuttttttt 660
tttttutttu utggatgaaa ttuutguuag utucgaagga aggagggaag aggagcgagu 720
cguagtgtag aaagtttuut tgautuutuu tucggutggg tutuuutuuu ttguuaaguu 780
uaguutgtga aautgaataa cgaagatuau tuaauaatgu utguuuutut utgautguau 840
cgtuucggcg utuuuaucgu cgucgucguc guuuaataga guuuutgggg cggtuuuuau 900
cgacggtgua guucgucggg aucgggagga aguagutgcg guuatcgcgu cgtgcgtucg 960
cguucggucg uuaggtguuu uagtaguucg aucgucgaga tguuuaguuc gucggggutu 1020
cgggcgutat ggutttgcgu cgcgutgtgc guttuucgga gggucggcgg cguuuuuuag 1080
uucgguucgg gguuuaucgu utguucgguu uuutguuaut guuaggagga cgguatuatg 1140
utgtutgucg autgututga gutcgggutg tucgucgttu cgggggauut ggauuuuutg 1200
<210>191
<211>1200
<212>DNA
<213>智人
<400>191
tttutuagga aauuaauuat cggguutuuu agauagtatu aaggcgutga aautuagtag 60
gtuuttgagg uuagauuuut uauuagtuat gautguutag utguutuutu aututuuuta 120
attuutgttt tuuuauauag ggtgauattt uttuuutgut utggaaautt utaattttag 180
tgggutgagg agagggattt gtgautgagc guuuatutut gggutgtagu auttgaatga 240
gguuttuttu uutgguautg utgttggtga ttggutttut gtguagggua ggggguutag 300
atgauaauuu tgatgtttgg gtaguautgt uautgtgaga gguatggaaa tuutuuagtt 360
uttagtuttu ttggaggaag gaattuagau aagagatguu taguaagagg tatagggtta 420
agtaauuttt atttaaagag tuaggatutu agagagauaa gauagaauut guuautuagg 480
agatagaguu aaaagutagt gauttaggag gaattutttt utttututtt ttttttttat 540
ttttttgaga uagagtutcg ututgtgguu uaggutggag tguagtggcg cgatutcggu 600
tuautguaag utuuauutuu cgggttuacg uuattutuut guutuaguut uucgagtagu 660
tgggautaua ggcguuagga ggaattutta tttgaguttt tagttaagga aaauagtaua 720
guttgaaaga ggaautgutu aaaagaatga gtuagtcgut autuacgutg gggagauuut 780
uttgatgaga gttttauagg attautuacg aacgguuuag guagggguut tautagtaag 840
uacgttttgg gaagtuutua ggguacguag guaucgtgau utuauauaut agtgcgutgg 900
agtgtgtuat taguatutgg aatututuuu uagggatgtg gtttttgttt tttttttttt 960
ttttggtatt ataatgagut aaaagutatt uaggggcgag ttatuagagg tgaguucgtg 1020
ututtuagcg gagaagatuu uutauutggu cgucgguuau tttutgtggg ucgtggggtu 1080
utuaaggaga cgguuuttgg gutuaggggu tgcgtttuua uacgcguutt tuuuagggut 1140
uucgcguucg ttuutguutg gucgucgguc gutuuaauag uaguauaagg cgggautuag 1200
<210>192
<211>1200
<212>DNA
<213>智人
<400>192
tgttatatgg atgtattgua tagtggtgga gautgggutt ttagtgtagu uatuauuuut 60
atagtgtaua ttgtauutat taagtaattt gttgtuuutu auuuuutuuu tuuutuuuaa 120
agtgattaua aatattaatg atgauagtga tgauagaaat tututuuaga tgtgatutga 180
gtttggaggg uaaagggatt tttgaaaatg aatuataaga gagaaatttt guaauaaagg 240
agtgtggtau atttaaattg utgttttttt ttttaaatau tgtgutuacg cggauutaat 300
aaautatuaa guagauutua tggaattuua uataatguag aagcgaggga aaaataggta 360
ttgagggaaa aguaguautg ttttuutuaa ttttaauacg tatgtguagu utauauttau 420
aaauttaaga uagtaguttt taauatgtga utttgutuag ggtaauagau uattutggtt 480
ataguuttau ttauagutgt ggaggutgaa tuutgatggg tutaagaagt gtuaggauaa 540
gtgttaggga tguauutgtu tgtutgtutt aagggaatac gggtutgggu agtuttaaat 600
cggagutuuu ttgaggagaa tgtcgtguag taguuttagg aatgtgaaua ttgggagaut 660
ggutgggatt ttgtaggtta tgagttgggg auauttatga tagtgaautt gaguuuagga 720
gagaaguuat aaaaagtgaa autgtuutgg guauttggag gtgagtgtut ututagtaag 780
atguatgtga aaggutggga gutgaaagua aggagaguag aagaggutgg tgaagattut 840
aatutgcgtg tuuaggggua ututtuuagg tutuaggaac guaggtuaga atgtguaagu 900
uagutgucgg guacgtggut uauuuutgta gtauuaguau tttgggaggu tgagagagaa 960
gatcguttgt gguuaggagt ttgagauuag autggguaau atagggagau uutgtututt 1020
aaaaaaaaaa aaaaaaaagg autgagtgag ucgaguuuag tuututgatg uautgtgtua 1080
ttuatuuuut ttuttaggut gtgttggttu taggutagut gutgtutttu tttggtaggu 1140
tgutaauutu tttggattgt gaatttaaaa uatgttttau agtaaatttg utguuaagau 1200
<210>193
<211>1200
<212>DNA
<213>智人
<400>193
gaautgaggg utuutuuuut ttttagauua tatagggtaa auutuuuuau attguuatgg 60
uatttataaa utguuatggu autggtgggt guttuuttta auatgutaat guattataat 120
tagcgtaaaa tgaguagtga ggatgauuag aggtcguttt utttguuatu ttggttttgg 180
utgguttutt uautguatau tgttttatua gtggggtutt tgtgauutut atuttattaa 240
auuagtuttg uuuaatttut atutuatuut gtgaucgaga atgcggauuu tuutgggagt 300
guaguuuagu aggtutuagu utuattttau uuaguuuuut gttuaagatg gagtcgutut 360
ggttuuaacg tututaacgc gggguuuutg autgututat ttuuuaaggt gtatutagua 420
tutcguauta tacgagguua agttaaggut tauauatttg uagaaggaaa gaggtaagga 480
aguaauutgg gauuttuuau tgtututgtt tuuatututu tutttuuatu tutgttuatu 540
uuagaatutu tutgtuuuta tuuutaaata tcgaaaattt utgtututga uuatutatua 600
ttgtggutga tuatutgttt utgauuattu uttuucgttu utgauuuuag ggagtguagg 660
gtgtuutagu uaagucggcg tuuutuutag tagtaucgut gutututaau utuaggacgt 720
uaaggguuta gagcgauaga tgtttuuuag uagggggttu tgaggutgtg cguuuagatc 780
gcgagagagg uaagtggggt gacgaggtcg tguautgagg gtggacgtag agguuaggag 840
taguaggcgg ucggggaaaa gaggtggaga aaggaaaaaa gaggagaaaa gtggaggagg 900
gcgagtaggg gggtggggua gagaggggcg gguucgagtg cguuuuucgu uuuuaguuuc 960
gututguuag utuuutuuua guuuagucgg utauatutgg cggutguuut uuuttgtttu 1020
cgutguatuu agauttuutu aggcggtggu tggaggutgc guatutgggg utttaaauat 1080
auaaagggat tguuaggauu tgcggcggcg gcggcggcgg cgggggutgg ggcgcggggg 1140
ucggauuatg agucgutgag ucggguaaau uuuagguuau cgaguuagcg gauuutcgga 1200
<210>194
<211>1200
<212>DNA
<213>智人
<400>194
agutuutgut utucgutuag tuuuauaguu ttuuuatgua agagttucgu aguttutuut 60
gacgautuut tuucguaaaa tuuuuauuuc gtuuatuagu aacgutgtgg autututgut 120
uutguauutu uuttauutuu uttgtuauac ggagaaggaa gagucggaua ggtauucguu 180
aggagggutg ututgtagut gggaauutua utgagtttgu aguagggguu agaattgtgg 240
ggaguuattu tagagaucgu attttutttt tttutttttt tttttttttt atgagatgga 300
gtuttgutut gtuauuuaag utggagtgua gtggcgcgat utuagutuau tguaagutuc 360
guutuuuagg ttuacguuat tutuutguut uaguttuucg agtagutggg autauaggcg 420
uucguuauua uauucgguta atttttttgt attttgagta gagacggggt ttuaucgtgt 480
taguuaggat ggtuttgatu tuutgauutc gtgatuuauu uatutcgguu tuuuaaagtg 540
utgguattau aggcgtgagu uautgcguuc gauuaauuuu attttuttaa tggtgucgua 600
gattgggaag tggutuuuag gguutuaguu tattgguatg uagguuaggu agtguuuagu 660
tgagagtggu tuauaaggat gagtuaggag gaaatgagcg gatgguagga gaggutguua 720
tutgtggucg uutguatggu uagguutgtt utuagcgutt tauagcgguu agttuagutg 780
ututuauutu aguuauutuu cgagagauac gtgggaggtg gaggutuaga gaggggaagt 840
uaggautaga guutggguat tttgataatg auaggagtga gacguaggtg gagaguaggu 900
uaggaguutg cggcguttut uutgtgagut guuuuuagga ggcgutcgtg tgttguuuat 960
cgutuuuauu uuttuttuuu tuuauatutu tagaaataua gacgutgcgt guaaaguaut 1020
gggtgutgat gtgguttagu atutuutgau auutgtgguu tgtuutuuut uuagucgggt 1080
gauauuuaga uuuuuagutu utguauauuu utggguaauu utgutgtguu uucggggtgu 1140
tgagcgtggu tttguuagtg tgtuagaggu atuaattgut aaaauaattc gguagaaatt 1200
<210>195
<211>1200
<212>DNA
<213>智人
<400>195
tatgtuaaga atgaaagatg gutuatuatt atggauuata uagacgttaa aaggataata 60
aggaaatatg utgaauaaut ttatguuaat aatutgauat utaataattg gatgaaatgg 120
auaaattuut taaaagaatt auuaaagttt attuaatatt auuttgataa uttgaatagu 180
uututagutg atguagaagt gaatttutua ttaaaaauut tuuuauaaag aaatutcgaa 240
guuuaaatgg gttuuuuagc gaatautauu auaattttta gggaataagt tauuuuatuu 300
tautuuuagg tuautguagg uucgguttaa aucgauuuua aauuagauag auauagaaaa 360
cgggaggtcg guuauagagu aatutguttu auuaguaucg tuuuuaauut tggauaaagc 420
gttauuaagu tgagtuaggu aatauauuaa aaggataacg aatcgtgauu aagtgagttt 480
tuuaaggaga guuaaauaat gtaattuuut atgggutgaa ataaaaagut auaggatuat 540
ttgaatauat guagaaaagc gttguagaaa atttuauauu uautuataag aaututtgga 600
aaaauaggaa tagagggaau ttuutuaaut tgataaaaaa uauuaauaaa aaacgautuu 660
taauatuaut utgggtggtg aaagcguaut tttuuutaat gtgtgggcgg uaagaaggcg 720
gauucgutcg aagutucguu uauuuacgcg agguuucguu cguucgutcg aaguuucguu 780
uauucggcgg tuauaucguu ttgcgcgutc gguatgacgt uautuuuauu agguauutcg 840
uuttgtuagg agutguuagg cguuaaucgu cgauututga ucgutacggg tuucggutcg 900
cguaacgauu uuaaggcgua tguuuaggcg cggcgauuuu attggtggcg ggcggcggga 960
gcggcgcggg cgcgtgcggg cggcgguagc ggcggtgacg guaguutagg ucgggcgagg 1020
guuatgutga guutcguagu uaagutggtg guuttuttut ggaggacggc ggauauuuut 1080
agggaggaag ucggguagut ggaguucgag utcgcggaag gtggutcgcg ggaggcggut 1140
gggaggcggg tuucggguuu tcgcgtgtcg guuacgaggg agucgcguuu ataggtuttt 1200
<210>196
<211>1200
<212>DNA
<213>智人
<400>196
agguuaggut gggtgauaag uuuuucgggt ggutguauut uuuautcguc gauutgggcg 60
utgtuuttgg tgutgucggc guuatagcga guauaagcgu uttauuttut guuuutgcgg 120
aagutgcgga cgtuuuuuaa acgttaaaaa cguuatatuu uautttttat auaaataaut 180
auuucgguut gttututttg tuuuuttuuc gaaguuttua gguagaucgt tucguaaagt 240
uttttttttt gttttgtttt gtuttutaga uuuagutuut cggcgutuat utuuagutgu 300
tttaagauaa ggggtggggg aaggggaggg agguaagaaa agatgagggt gggggagggg 360
aaaagaggga atguaagggg aaggagggag gagacgggga gaaggaaaga ttggaagaaa 420
aggatutucg aggaaggggu tgagagaagg guagggtgaa utggautaaa gguuagagta 480
ggaaggagaa gagggguuaa aaaagaaggg gatgaaatta aguauagaag atgggtaaag 540
aaaaaagtat uagggaaagg guaaaataag agaaaguutt gaggataaga gggtagaagg 600
utaaagaaua aggggauuau tgggtcgggg aagcgutguu tgaacggcgg gauagtgaua 660
aagaaagggc gutggcgata ttcguauuaa gggtgcgaaa cguaatcggg aggtgagaaa 720
tggaaagaag gcgaatguuc ggutauaagt aguutgggau tgaaagggga uutgggggag 780
gggutggguu uaggguagaa aagtuuaggt tuuuatgcgg uutggguuua cgtggagcgg 840
gcgutgaatu aucgttuagu cguuuuuutu uuutuutuuu cgaucggtgu ucguagtuuu 900
cguutuutcg gucgucguut uuacggggcg ggguuutggu ucgggauuag cgucgcggut 960
ataaatgggu tgcggcgagg ucgguagaac gutgtgauag uuauacguuu uaagguutuu 1020
aagatgagut auacgttgga utcgutgggu aauucgtucg uutaucggcg ggtaaucgag 1080
auucgutcga guttuagucg cgtuagcggu tuuucgtuua gtgguttucg utcguagtcg 1140
tggtuucgcg gutcguuuag uaucgtgtuu tuutuutata agcguaguat gutcguuucg 1200
<210>197
<211>1200
<212>DNA
<213>智人
<400>197
agaatgautt utgtttuuut tuutgaaggu ttuttggtgu agtgttgagu tauaggaagg 60
uautaguuau atgaguaggg uuuttgutga aauuuuuttu utuuaggaag uuttutttga 120
utguuatagg utguagaggu tuututuuuu uauuttgtta tagutaauag aauuautuag 180
ttuagagutg gtggtuttut gatgatutgt uucggagatu tgttuuutua guttgguuag 240
agutuuaggu ttgtgagtut ggtucgcggg uattuaaagg uuutuagtgg uatutgtgua 300
tuagtgagau tguucggggt tuutgututg aauuuttguu utagtguuuu taguutggut 360
gagaacggag ggtuaagtgu cggggttuta atutuaatta utttatuuaa guatucgutc 420
gutuatttau atgtttuuut gggututuua ututgcguua gguucggtau utggagutag 480
ggaaaucgaa uattagtgut ggutcguucg uuuucguatu cggggagutc ggcgttutcg 540
cgguuutgut uuuuttgttt tuaagtguaa gttuuatgtt tucgtgutgg gaataagguu 600
aguuucgggt guuauuatau tcguutgatg tuttauuucg auucgcgucg ucgagagutt 660
gcggutacgg gaacgcggcg cguuucgggg uuauatutgg uutagcgggc gcgcgcgtgt 720
uautaagacg utuattuauc ggcguagutg tuauuataau aaucggagcg agggaatuut 780
ggagautguc ggggcggggg gcgggggcgg cggtcguagg agggauucgg cgcgggcggg 840
aucgcggcgg tcgggggaua uuagutgcgt cggagcguuu agaacguuuc gcgutucguc 900
gaguuucgut uuacguagau ucgcgggcgg gagggaguua cguauatcgu cgucgcgguc 960
gtutucgcgg ggcggtaauc gaguutguut cggagucguc gaacguuuac guuagcgauu 1020
utgaututat gguuucgggg gagcgcgucg gagucgucgc gucguuuauu uuuagucgga 1080
auuutagcgt uucggggagu aagcggggag uuucgggcgt uuucgguuuc gguuuagggu 1140
uutguttgtg guuuucgutu ucguuacggg guatgggagg uaggtaguuu aguutgcguu 1200
<210>198
<211>1200
<212>DNA
<213>智人
<400>198
uucggggttu utgututgaa uuuttguuut agtguuuuta guutggutga gaacggaggg 60
tuaagtgucg gggttutaat utuaattaut ttatuuaagu atucgutcgu tuatttauat 120
gtttuuutgg gututuuaut utgcguuagg uucggtauut ggagutaggg aaaucgaaua 180
ttagtgutgg utcguucguu uucguatucg gggagutcgg cgttutcgcg guuutgutuu 240
uuttgttttu aagtguaagt tuuatgtttu cgtgutggga ataagguuag uuucgggtgu 300
uauuatautc guutgatgtu ttauuucgau ucgcgucguc gagaguttgc ggutacggga 360
acgcggcgcg uuucgggguu auatutgguu tagcgggcgc gcgcgtgtua utaagacgut 420
uattuaucgg cguagutgtu auuataauaa ucggagcgag ggaatuutgg agautgucgg 480
ggcggggggc gggggcggcg gtcguaggag ggauucggcg cgggcgggau cgcggcggtc 540
gggggauauu agutgcgtcg gagcguuuag aacguuucgc gutucgucga guuucgutuu 600
acguagauuc gcgggcggga gggaguuacg uauatcgucg ucgcggucgt utucgcgggg 660
cggtaaucga guutguutcg gagucgucga acguuuacgu uagcgauuut gaututatgg 720
uuucggggga gcgcgucgga gucgucgcgu cguuuauuuu uagucggaau uutagcgtuu 780
cggggaguaa gcggggaguu ucgggcgtuu ucgguuucgg uuuaggguuu tguttgtggu 840
uuucgutuuc guuacggggu atgggaggua ggtaguuuag uutgcguuag gauauucgtg 900
gcgggcggaa uucguuaagg aucgcgaagt uuagagaaag gaagutgagg agutguucgu 960
ucguuuucgg utguaguuuu aguaggguuu tuuuucggtg gcgcguauuc gcgcgcguau 1020
autcguauau cguauutuag cguutguucg guutcguuuu uauucgcgag cgucgaauut 1080
uutggggucg gatguuatgg gtaauaautt utuuagtatu uuutcgutgu uucgaggaaa 1140
uucgagucgc gcgucgcggg guuauuuuua gaauutuaaa ggtaggutuu ucggucgagu 1200
<210>199
<211>1200
<212>DNA
<213>智人
<400>199
tgutuuuaag tguttatgag uuuatgtata tguauatttg tgtgauatga tguagaagaa 60
tagtguaggt utgtgttggg gtgtgtggtg tgtgtgtatg tguatggtta aagggatagg 120
ttggtgtggg ggggaaaagu utggattutg gtgutguaut guutgggttt guattuuagu 180
uttguuauut tttaggtgag uaguututut ttgtutuagt tttutuatut gtaagauuat 240
uatuatuatu ttagagatgg tauutgttga tutgttgata atgautgtaa tautgauutu 300
atuattuagu utgtgaggau uaaaggagtt aatauttgua aaguuuttgg aauagaguut 360
ggaagaagau agaaacggtg ttaguauttg gttaauagut uuatuagutt gattgtgaau 420
ututtgaggg uagggacgat gtutgttttg uttuuuaggg ggtuuuutut uauutaguag 480
gauututgua tgtagtaggt guatgaggut agtgaatgaa tggutgtcgg uutgggcgtt 540
uagggagggu tgtgtgtgtu autauatuuu tgagatgggg utgtgtgtga tggggatgtg 600
tgtgcgtgtg cgcguututg utcgutttut ggagutcgut gutatttuag gaaguutuua 660
gtutuutuut uuttatgtaa ataaauatga uagatuuuat cggutgtauu agcgcgggag 720
gtggggaggu tggagtgggt gggagcgggg aggcggcggu cggaggggtg tgcgtgutgc 780
gtgcgcgtgt ggucggutgg ucgcgggcgg gcggcgtgcg cgtgtgucgg agggggcgcg 840
tgggggcgcg tgggggcgcg ggagggguut cgguuutguu atgucggtut ucguucgcgg 900
gggaggagac gggggaggag gaggggagua gucggucggg gcgautcggt gauuagucgg 960
ucgguuuagu agaggtggut guautguucg tcgucggaga tggggggaua gatuauucgg 1020
aguaututuu acggtaaggu uucgcggatg uutgcggguu cguuuauuuu aguucgagau 1080
cguutgggga ggucgggcgg aggggcgutg gggutgaggg uttggtuatg uuuutauttu 1140
tuautuuatg gaggggtutg gggutgtgtg gggguauutt ttggtggtgg guautggggt 1200
<210>200
<211>1200
<212>DNA
<213>智人
<400>200
gaucguutcg guututuaaa gtgutgggat tauaggcgtg aauuauuatg uuuaguutat 60
uuttttgttt tuuatuutgt gttgguttgg tgggggagag gaggtgttga uacgtggagg 120
auauauatat aagguattut tgggtgautt cgtuatuaut ggauuutatu tutuaaaatt 180
uuagcgaaat utgututtuu utttaaggag tgaaagaagg gtuaguattu uagaagttuu 240
tggtuatauu uaggutttta atgaattguu autggggaat uaguatuucg ttgutgtaag 300
gautataaga tggcggattg tgagaguata gggaaaggtu tcggaggtut uttgtuuttg 360
utuuacguag gtutttutgg uutgaaaatu ucgttgaaga gaguagutut tgagagtttg 420
utuuaagttu uutcggggtg atuaguauua cggauagcgg uuagggcguu uucgaggauu 480
cguagguagg uagggtguau agcggcgagu aggtgutgcg utacgtgcgg guuagggaau 540
tcgcgcgggg aggggagagg cgucgcgggt ggcggggtut tggucggggu tgttttcgut 600
gtgagtuauu ucgtgutuuu cgcgutuacg tcggtuutcg gaaagucggg gtuutuuutg 660
uuttttuuag uaacggtggg gtggggaggu aggaagaaag cguuaauuta ggauauutgg 720
auatttguag gaaaggaaga agcgggagac ggggauttgt utgtgtutuu agcgcgttuu 780
tguuuuucgg uucgauucgg uuuatttuta tauaaggtcg gututguucg gtutuuauut 840
uuuacgtcgu aggcgcggag gggutuattu ucggguuutg atutuagagg uucggaatgt 900
ggutgataaa tuagagataa uuutguatgg uaggguaggu ucgauautua gutuuaggat 960
aaaagguuac ggtgtuucga ggaguuagga ggaguauuuc guaggutgag gguaggtggg 1020
aaguaaauuc ggacguatcg uaguaguagu aguaguagua gaaguaguag uaguaguutu 1080
cguagtuuut uuagagauat ggatuuuuag auaguauutt uucgggcgut uutgutuutg 1140
ututtuttgu atutgguttt uutgggaggt cgttuuuauu cgutggguag uuucggttua 1200
<210>201
<211>1200
<212>DNA
<213>智人
<400>201
aggaaagttu tgguatttgg uagattaagu aagtgtuttg atttgaagtu uagtttagtu 60
uuaatautuu utuuuauauu uauuauatcg uauaatttgg ttttgtttat ttautuuagg 120
ttaaggtaga gtututtagu ttggtttgag tgutgtautu ttutututgg tutgatattt 180
ggaautaaag uuaaguuaga autuuagggu uaagggggat gttgaaaatt gtutgagtuu 240
uuagauuauu utguuagutu atgguaaagg gagggatuag agguuauagg gaaaguautt 300
uagutgutut tuauaguatu auuututuuu uatttaatgg tttaggttaa uaggautttt 360
tuuttgaggu ttgggauacg gaagggaguu tuuuutaaau uagguuuttg gagaguaggu 420
uuuaggggag uagtguaaut uauuttuaua uuuauaagac ggutuutgau ttutgutuuu 480
tuutuuuutu uuuaaagtgg aauagagaga atatgattuu uuacgauttu uauatuauag 540
tttuuaaaua atggggaaat cggagguutu uucgtgtgua gacggtgata tttaucguua 600
aatgcgaauu agguagatgu uaguuuuagu acguacguag gtaauttuau uutcguutua 660
acgauutuag aggutguucg guutguuuua uacgggggtg utaaguutuu cguucgttut 720
aagcggagau uuaacguuat uuataattaa gttuttuutg agggcgagcg guuaggtgcg 780
uuttcgguag gauagtguta attuuaguuu utttuuagcg cgtutuuucg cgutcgtuuu 840
ucgtutggaa guuuuuutuu uacguuucgc gguuuuuutt uuuutgguuc ggggagutgu 900
tuuttgtgut gucgggaagg tuaaagtuuc gcguuuauua ggagagutcg guaagtatat 960
aaggauagag gagcgcggga uuaagcggcg gcgaaggagg ggaagaagag ucgcgaucga 1020
gagaggucgu cgagcgtuuu cguuutuaga gaguaguutu ucgagauagg taagggcgua 1080
gcgtggggga uucgtgutut ttuuucggga tuuuutgtuu ucgtuutcgc gatguagtcg 1140
gucggutucg gutucgaagg cggauutggg cguututggu tutucgcggt uucgagttut 1200
<210>202
<211>1200
<212>DNA
<213>智人
<400>202
gacggagutt ggatututut tgtggtuuaa agggaaagga ttgutgaatg taaaguuaat 60
gtuauuagaa aagutgaatu uauaagagag tuutggagtu uaaaagagua tutuatgggg 120
aatuaggaaa gttutgguat ttgguagatt aaguaagtgt uttgatttga agtuuagttt 180
agtuuuaata utuuutuuua uauuuauuau atcguauaat ttggttttgt ttatttautu 240
uaggttaagg tagagtutut taguttggtt tgagtgutgt aututtutut utggtutgat 300
atttggaaut aaaguuaagu uagaautuua ggguuaaggg ggatgttgaa aattgtutga 360
gtuuuuagau uauuutguua gutuatggua aagggaggga tuagagguua uagggaaagu 420
auttuagutg ututtuauag uatuauuutu tuuuuattta atggtttagg ttaauaggau 480
tttttuuttg agguttggga uacggaaggg aguutuuuut aaauuagguu uttggagagu 540
agguuuuagg ggaguagtgu aautuauutt uauauuuaua agacggutuu tgauttutgu 600
tuuutuutuu uutuuuuaaa gtggaauaga gagaatatga ttuuuuacga uttuuauatu 660
auagtttuua aauaatgggg aaatcggagg uutuuucgtg tguagacggt gatatttauc 720
guuaaatgcg aauuagguag atguuaguuu uaguacguac guaggtaaut tuauuutcgu 780
utuaacgauu tuagaggutg uucgguutgu uuuauacggg ggtgutaagu utuucguucg 840
ttutaagcgg agauuuaacg uuatuuataa ttaagttutt uutgagggcg agcgguuagg 900
tgcguuttcg guaggauagt gutaattuua guuuutttuu agcgcgtutu uucgcgutcg 960
tuuuucgtut ggaaguuuuu utuuuacguu ucgcgguuuu uuttuuuutg guucggggag 1020
utgutuuttg tgutgucggg aaggtuaaag tuucgcguuu auuaggagag utcgguaagt 1080
atataaggau agaggagcgc gggauuaagc ggcggcgaag gaggggaaga agagucgcga 1140
ucgagagagg ucgucgagcg tuuucguuut uagagaguag uutuucgaga uaggtaaggg 1200
<210>203
<211>1200
<212>DNA
<213>智人
<400>203
ggattauagg uatgtguuau uagguuuagu taatttttgt atttttagta gagatggagt 60
ttuauuatgt tgguuaggut ggtuttgaau tuutgauutc gtgatuuauu utuuttgguu 120
tuuuaaagtt utgggattau aggagtgagu uautgcguuu aguuauattt aaattttaga 180
gtataattat tgutguttat aattagaagt gagaagautg ttttgaagta agggauttuu 240
utgguuauuu tcgutaaaat tguaauutta uuutuautuu atttutuutt ututguttta 300
tatttutuua aaguauttat atgataataa autgtataat aucgtautta utgtgtttut 360
uatgtatuuc ggutauaaut gtuaautgcg tgggautggt tttgtutgtt ttgttuuutg 420
ututatuuut ggagcgtaaa guagtgtutg gtatagagtg gatauttaat agatattcgt 480
tgaaucgggu uagtggcggt ggutuacguu tgtaatuuua guautttggg aggcggaggu 540
agguagatua uttgaggtua ggagttcgag guuaguutgg uuaauatggc gaaatuucgt 600
ututautaaa aatauaaaaa ttagucgggt gttgtggtgu atuuutgtaa tuuuagutau 660
ttcggaggut gagguaggag aatcguttga auutgggagg cggacgttgc ggtgagucga 720
gatcgcguua ttgtautuua guutgggcga uaaagagaga uatcgautua aaaaaaaaaa 780
aattcgttga acggaatgag tgaauaaaua aatggatgga tgagtgaatg aatgaacgaa 840
ggaauaagtg aucgutcgau uttutauagc gauagcggcg uaggcgutuu cguauuaaua 900
guuuuuuauu ucguuaucgu uagagggcgu agauaggucg ggtuucgagt gtutgtuuua 960
gguuuucguu uuauaggatu ucgguucggg aguuuucgat guagggauuc guucgggaut 1020
utgggtuuuc guuuatauut uaauttcgua cgautgcgtg uutuaagucg acguagcggu 1080
utaututcgu autguagacg gggaaautga gguutgaggc ggucggggtg ggguagauut 1140
uucggcgagu ucgaguuuuc guuuucggut aguuucguuu tgguucgtaa gaaguauucg 1200
<210>204
<211>1200
<212>DNA
<213>智人
<400>204
aataaauttu uatgttgttg ttgttgtttt gaaacggagt gtuaututgt uauutgggat 60
ggagtguagt gguauaguut tggutuaucg uaauutucgu utuutgggtt uaagtgattu 120
tuutguutua guutuutgag tagutgggat tauagatgua uacgauuacg uutggutaat 180
tatttgtatt ttgagtagag atggggtttu auuatgttgg uuaggutggt gttgaattuu 240
tgauuttaag tgatutguut guuttgguut uuuuaagtuu tgggataaua gguatgaguu 300
autguauuua guuaaauttc gaggtatata attaaaagtt taataaguuu tuaguutaat 360
tttaaaattu agattutttu tttutttutt tutttcgttu tttutttutt tutttutttu 420
tttutttutt tutttutttu tttutttutt tuttutttut ttttutttut ttuttgataa 480
uattattatu atagtutggt agattutgtu tttutataat aaaaatuutg tgatgttgtt 540
uaaagaaaut uaatgggutt tutgtatgtt tauuaaggaa ttaaaatutt aauaaaggtt 600
ttuaauauaa gaaatautuu uttttgtaag aattuttuat aggtttttut aguauaagtt 660
tgtttttatt gaatgataut tgatggttut gtatgttatt tuttttutau tauatataat 720
tttgattagg ggatauatta aatattttaa aautatuatt tutttttuua gaauaatuat 780
aauatgtttt guttuttgtt gutttaaaag gaauatttta agttgutttt ttauaauaat 840
aagtgtgaaa ggaaatguua aaatauaaau aatttuautt uttgttggaa tttgauattt 900
uuautaguta agtaatataa auatguatua uutaaatgag uagtatttta ataguatcgt 960
tttuauattt taattgttgt uauatttutt utttgtttag ggagacgtut ggtgaauauu 1020
cgtgggatut aaagaauaag taagatttaa aguatautgg gttgtgtguu tggutttuau 1080
attttattta ttttattgut taatagtgtt tutttautau tgtgggttgt aguttaaaat 1140
tgttagaaat tttattatgg agtataagga ataaaagtga acgttuaaua utttuaaatt 1200
<210>205
<211>1200
<212>DNA
<213>智人
<400>205
uutguutttg uatagaattu utggaatguu ttttcgtuat uttgttaaaa tuutggttaa 60
auttuaaggu utagtttgag auautatttu uatgatgtua gtuttgatuu tatuttttat 120
aguattatut ggttttuutt uutggcguta atuauttatt aaattgtaut aatuatutgg 180
tgtauutgut ttattttuuu tautaatutg gaaauaaaaa taatagaauu tgautuatut 240
ttutguuttg agauauuttg tgutgtuaut uttgatguut tguauauagt aggtgututa 300
aaaatagttt gtgguttttt gattttauag agaagautga ggaaattaaa uuuttguuua 360
ggagguatat aaaaatuutg ttaaatgaaa gaggutuatg utaautattg ttttgautta 420
ttgatguuaa autagauttg aauattgatg tgtuttuagg gaagaaguua aatatgutag 480
tgtaaaaaat tutaauutut gutatttauu tggagaagtt gaattaguuu tgtuatttua 540
autgatguua aaaaaguagu ttuuattatt gtgtuagtaa tagautttta tuutguatgg 600
aggaauttut uttaaatutt tutuatagua utggtgtgut tutttguaut gatgtattta 660
cgtaatgttt uataagaagt gauagttuut tttttaggtu tttguuuaaa aggtgguata 720
aguaaagaat gaaagtuaag gtggttggut ttaggagagu utaaaattgg gaatgcgaga 780
gutuuuacgt aauauaaauu cggatagtut aagautuuta uattttauaa auuaagttat 840
ttuuttuuta atauaaauaa agtatgauag ttauaattta ttgtgtattt auaatggatt 900
gtgtutgtua tggtgattgt gatggaauua ggggggaaag agtaagaaat utaaguautt 960
ttgtgttttu ttuuttttut tttututtuu tuuucguttt uaggututga aagtgttuua 1020
gutgaaattt uagatcggau agautcgutg cggutucgga gguagtgatt uuaagutgut 1080
cgcguacgut gutguuaagu tguaggatgg tguacgtagu uaggutgutg utgutgutuu 1140
tuautttutt uutucguacg gatgutgaga gtaaguuatt utuuuuttut utagggggut 1200
<210>206
<211>1200
<212>DNA
<213>智人
<400>206
aaguaaauut agataaatgg gauttuatuu aautaaaatg uttutguauc guataggaaa 60
taatuaauaa aatgaaaaaa uaguutatag attgggagaa aatatttgtg aguuatatat 120
utgataaggg gttaatatuu aaaatauatt acgttuauag aautuaguua aaataaataa 180
ataaaauauu uagttaauta acggguaaag gatgtgaatg gauttttttt ttttttuuag 240
aggaagtaua aattguuaau aggtataaga aaaggcgutu aaaatuauta atgaauaggg 300
aaaaguuaut aggtatutuu tuauauutgu taggatgaut gttataaaaa agataagcga 360
taataagtgt cggtgatgtg cggaguaaag ggaauuttgt auautggtgg tgggaatgcg 420
gautggaaua guuattatgg aaaauuutac ggaggttuau tuaaaaagtt aaaaauagaa 480
utauuaguuu agtgttatuc gtuuttcgtt aagttuaaag tuacggtguu auttuutttu 540
uuatutaaag gggautgutc gcgauuuaag uuaagguucg uaagtgtggu tutuuutgcg 600
gggagagtag gguaggaggt ggatttuuag guuagaggut tuuaggutgg guucggauuu 660
uacgucgauu ucgguuucgg ggggggutua gcgauutcgg cguutuutua gguuuuuagt 720
gaauutucgg gguuuataaa ggutuuaggu cggutuuucg gagguuuauu agcgggcgtu 780
tggguutuuu tucgcgucgc gaucguuagg aggcgucguu cgggagagga agtuuagutg 840
gguucggucg gguttcggag gcgucguucg ggagaggaag tuuagttggg uucggucggg 900
uttuagaggc guagggcggg agucguutcg cguagggtuu tuuuuaaguc ggcguuaggu 960
uutguuutcg tucgguuutg uuutcgtutg guuucguucg ggucgcgagu autggcgggt 1020
tutgggtuut gtgaucggtu aggcggcgtu agcgggcgcg gcggagggut ggucgguutc 1080
gggggagttt ucgcggucgu cgggggcgcg gcgguagagc gcgaggucgg guaggggguu 1140
agautcggag tcgaggcgcg uucgauaguc guagcgutua tggcgggcgg aggagucggg 1200
<210>207
<211>1200
<212>DNA
<213>智人
<400>207
aguaaauuta gataaatggg auttuatuua autaaaatgu ttutguaucg uataggaaat 60
aatuaauaaa atgaaaaaau aguutataga ttgggagaaa atatttgtga guuatatatu 120
tgataagggg ttaatatuua aaatauatta cgttuauaga autuaguuaa aataaataaa 180
taaaauauuu agttaautaa cggguaaagg atgtgaatgg autttttttt tttttuuaga 240
ggaagtauaa attguuaaua ggtataagaa aaggcgutua aaatuautaa tgaauaggga 300
aaaguuauta ggtatutuut uauauutgut aggatgautg ttataaaaaa gataagcgat 360
aataagtgtc ggtgatgtgc ggaguaaagg gaauuttgta uautggtggt gggaatgcgg 420
autggaauag uuattatgga aaauuutacg gaggttuaut uaaaaagtta aaaauagaau 480
tauuaguuua gtgttatucg tuuttcgtta agttuaaagt uacggtguua uttuutttuu 540
uatutaaagg ggautgutcg cgauuuaagu uaagguucgu aagtgtggut utuuutgcgg 600
ggagagtagg guaggaggtg gatttuuagg uuagaggutt uuaggutggg uucggauuuu 660
acgucgauuu cgguuucggg gggggutuag cgauutcggc guutuutuag guuuuuagtg 720
aauutucggg guuuataaag gutuuagguc ggutuuucgg agguuuauua gcgggcgtut 780
ggguutuuut ucgcgucgcg aucguuagga ggcgucguuc gggagaggaa gtuuagutgg 840
guucggucgg guttcggagg cgucguucgg gagaggaagt uuagttgggu ucggucgggu 900
ttuagaggcg uagggcggga gucguutcgc guagggtuut uuuuaagucg gcguuagguu 960
utguuutcgt ucgguuutgu uutcgtutgg uuucguucgg gucgcgagua utggcgggtt 1020
utgggtuutg tgaucggtua ggcggcgtua gcgggcgcgg cggagggutg gucgguutcg 1080
ggggagtttu cgcggucguc gggggcgcgg cgguagagcg cgaggucggg uaggggguua 1140
gautcggagt cgaggcgcgu ucgauagucg uagcgutuat ggcgggcgga ggagucgggg 1200
<210>208
<211>1200
<212>DNA
<213>智人
<400>208
aagtguuuau uuaaataguu tuatuattgu tgagggtutg tauatgauag tgautggggc 60
gtagguagut guauauauua gggutgagtu uuaguauacg tgttutauut gtgtgautuc 120
gaguuttaut tttutuatut gtauauagtu tutgtutuaa ggutattgga atgagtuaat 180
gatagagtgu acgtaaatua uttguauaga gagttgttua aauaatggta gutagaautg 240
utattgatut attgtggggt aattgtutta autgutttga aggattuagu uutatgtgtt 300
uutttgtuua gtuagatggg aaaatataaa tgaguuuttu tuaatgttag gaatgauaag 360
atuagguuaa gauuuututt tutuagauta tucggaagat auauagatga uutggauagt 420
gtutguaggu tuutgtgtat uutgaggutt uutgaggguu aagttutatg ggtgggaagg 480
uaguttgutu tutaggttgu uataaututg uatutgattt guatgtgttt gtggtgauuu 540
tguagtttut tutgguattt uuaauttaaa atattgutgt ttuuuuaggu aggguagata 600
ttgatttttt tuttututaa uuattucgat tgauucggut uuuuuauuua gcgaatgggg 660
gagggagggg gtgggggtga ggaagtggat gggggagaag ggaggaggga tggtgttguu 720
uttataguta guauutttta utucgtggaa uutgagtuau cggggutgat gagaatgggu 780
tutttuuaga aguaagtgua tgatgaagaa agaauagagg gaatgttuuu uutcgggtuu 840
atuutggtuu uttutttuuu tguatuuutt atatgauutg uagttuuutg agtuuauttg 900
uuaucggggg cgggtgguau uuaggcggcg gggaggcggg ggaggggcgu agtgauaguc 960
gagucggutt tgaggaauut tguagaggaa gtgguttuag aautguttta cgcgaggggu 1020
aggaaaggcg cgggaggcgg gggaggtgcg gagatggcgu tutguacggc ggcggaggga 1080
gggcgutggc gucggggaua cgaaaucgua gaguucggac gagtuaggga gtgaggcgcg 1140
agucgggcgu ucggggutut guaggcguag gcggcgcggg gauaggagua ggttaucggg 1200
<210>209
<211>1200
<212>DNA
<213>智人
<400>209
uttgaaguaa guuttuacgg gggaaagtgu cgggagaaag gagatututu tttgggtuuu 60
atgagtgaau uatuuatauu aggttuuaut taggguattt aggggaautg gtatutuuau 120
agtaattaut agaguagutu tggggaacgg agggttggut aaggaagaaa agutuuuuua 180
auuuttgggg cgagggagcg ttututuaat ggaguuuuuu uaautuuuut uuauuuuuua 240
uuagtuttuu aggaaagagg aatauuutau ucgguagggu tgcgaaggaa ggggaaatuu 300
aauuagagcg aaagtcguac gcggauagut utguuaguuu ttggagguat ucggcggtua 360
uuuacgggau aaagcgcggu tgcgggagcg cgcgcggggu attucggauu cgcgtcgagu 420
tucgututag agggggcggc gggcggcgau aagucggaga gaggaagggu uaaggaguac 480
gguuutuutg tcgguauuat uagcgggaga gtggcgagcg gacguutaga cggagggguu 540
utautuagau uuuatcgagu uagttuuuaa guttttuuut ucgauutgut uuutuucggg 600
gcgcgtgagg gtgcgggtcg ggggtgaauu tggtgttggg gaaagtgatt gguaagggaa 660
agagguaggg utgaagguut aggguuuuuc guagaaatgc guuututgag utgtautgta 720
uagaggcgut uututgcgga atuutguagu tgutuuaggt gaagacguuu uuaaatuuau 780
autcgcguag acgtcguutg guacggauuu tauuuuuttc ggtucgtcgg cggttututt 840
gggtcgtuut tuutguuaut ucgaututuu ucguuuucgu uucguuuagu aggutgcggt 900
tuutttaaag gcgcgutggt gtggggcggu uuuttututc ggggutggut cgggagtagc 960
guagtcguua aagucgucgu tguuaaagut gucguuauta gucggguatg guuatggcgt 1020
uuucgguuat cggguagcgu ucgtauucgu tautattgga uuucgagucg ucgcgutatu 1080
tauagaguut gagcgguuuc gagutaucgu cgucguuuuu cgaucggtuu tcgcguutut 1140
gtgtuucggc guuuututuu autgcguucg gggcgcgcga ggggcguagc guucggaggg 1200
<210>210
<211>1200
<212>DNA
<213>智人
<400>210
ttuaagatgg tgaucguaga gcgttaaauu agauaagggt uuatgaaggu ttgaaguaag 60
uuttuacggg ggaaagtguc gggagaaagg agatututut ttgggtuuua tgagtgaauu 120
atuuatauua ggttuuautt aggguattta ggggaautgg tatutuuaua gtaattauta 180
gaguagutut ggggaacgga gggttgguta aggaagaaaa gutuuuuuaa uuuttggggc 240
gagggagcgt tututuaatg gaguuuuuuu aautuuuutu uauuuuuuau uagtuttuua 300
ggaaagagga atauuutauu cgguagggut gcgaaggaag gggaaatuua auuagagcga 360
aagtcguacg cggauagutu tguuaguuut tggagguatu cggcggtuau uuacgggaua 420
aagcgcggut gcgggagcgc gcgcggggua ttucggauuc gcgtcgagut ucgututaga 480
gggggcggcg ggcggcgaua agucggagag aggaaggguu aaggaguacg guuutuutgt 540
cgguauuatu agcgggagag tggcgagcgg acguutagac ggagggguuu tautuagauu 600
uuatcgaguu agttuuuaag uttttuuutu cgauutgutu uutuucgggg cgcgtgaggg 660
tgcgggtcgg gggtgaauut ggtgttgggg aaagtgattg guaagggaaa gagguagggu 720
tgaagguuta ggguuuuucg uagaaatgcg uuututgagu tgtautgtau agaggcgutu 780
ututgcggaa tuutguagut gutuuaggtg aagacguuuu uaaatuuaua utcgcguaga 840
cgtcguutgg uacggauuut auuuuuttcg gtucgtcggc ggttututtg ggtcgtuutt 900
uutguuautu cgaututuuu cguuuucguu ucguuuagua ggutgcggtt uutttaaagg 960
cgcgutggtg tggggcgguu uuttututcg gggutggutc gggagtagcg uagtcguuaa 1020
agucgucgut guuaaagutg ucguuautag ucggguatgg uuatggcgtu uucgguuatc 1080
ggguagcguu cgtauucgut autattggau uucgagucgu cgcgutatut auagaguutg 1140
agcgguuucg agutaucguc gucguuuuuc gaucggtuut cgcguututg tgtuucggcg 1200
<210>211
<211>1200
<212>DNA
<213>智人
<400>211
tautuaggag guuaagauac gagaatcgut tgaauutgag gggatggggg guagaggatg 60
uagtgagucg agattgucga gatagcguua utguattuua guutggguaa uagtgagagu 120
utuuatutua aaaaaaaaaa aaaaaaatgg auttuttuut uattgauutg tggtggutuu 180
aagguuatua aaaaaaaaaa aaatggautt uttuutuatt gauutgtggt ggutuuaagg 240
uuatuatutu auaguutttt tttttttttt tttttttgag acggagtutt gutuuuttgu 300
uuaggttgga gtggagutgu atgatutcgg utuautguaa uutucguutu uuaggttuaa 360
guattutuut guutuaguut uutgagtagu tgggattaua ggcgcgtguu auuacguuua 420
gutaautttt guatttttaa tagagacggg gtttuauuat attggtuagg utggautcga 480
autuutaauu tuatgatucg uucguutcgg uutuuuaaag tgutaggatt auaggcgtga 540
guuautgcgu ucgguutuat utuauatutt tuttuututg uaguauacga uacguuutag 600
ttggaaauaa agtcggagtt tgtggattgg gggaagggcg gggtutaauu tuaggtuagg 660
cgucgtguaa ggtauatutt gguauucgga agagguuuag tauagttguu uucgaggtga 720
uucgauutuu uutauuaatt gaggcguuut tgttguuagg uttgcggcgg gggagcggcg 780
ggggagcgac ggggatgcgu tuattggtua aggaaggggc guutgttaut agaggcgaga 840
aucggaguuu attggtcgga auauutuaua atggauuuua gcggcgcgua aaatuuttat 900
gattggtttg utggutguut cgggagauuu tgttguuagg atauttggcg ttuucgauuc 960
gauuuucgtt uuuuattggu tgtuagggua aaagucguua tutaatgagg agcgaggtgc 1020
ggtguuucga agcgutcgut tuucgcggtg cgatutagtu utguagtagg cgguucgggg 1080
uuauaucgcg gucguuuaag uuagtguaag guuuaggggu utgauatcgu tuuuagcgut 1140
cgaggaucga gguutgutgt ggaggauauc gtgutuuutc gggauutgut utggattucg 1200
<210>212
<211>1200
<212>DNA
<213>智人
<400>212
uaaaaaguag ucggggatgg ggcgagaaua gaggauttuu uuautgaguu uauatuuaau 60
utuauuuaga auuuuttutu aggtuuagtt gutgutuuut attaggggta aatgtgttta 120
tgcguatuat ttuuatuatt tutttggggg aaaattggat tutttuutuu tuutcgutau 180
tcgututucg aututguuag uuuatutuut gagagttutu utgtgtaagg gatguaaggg 240
uuauuaguau uaggtututg aaaggacguc ggaguuagtt tucggtttuu aagggttgga 300
uuagtgutgg aggggggaat uauaaautgu uuttuuagga uuutauuutu tutautauuu 360
uaggatgutg aaaaagguta ttutguutut uttuuuutgu tuagututtu uucguutuut 420
guutucgguu uuaguagagg ucgcgutuuu autgcguutu tcguututga gaaatggcgu 480
aguaagcgut ucgcggagag uutggaggcg gggcguuutt ututgagtuc gcggggtcgu 540
auuucgaguu agtcgguuag auutguatuu cgcgtaguat uuutguuutu tutgtguagc 600
ggaaagggua aaagguaggg autguaagcg ggcgcguauc gggtaggaag agcggututg 660
cgtaggtgcg cggauucggg utuutgggtt uuatuuucgu cgcguauutc ggggtucgua 720
uucggutuut gucggguuut tttcggucgu auuucgutuu cguauuucgu tuutuuuuaa 780
guuuuauucg guuuaagucg cgcgtuucgu autgagutuu tauacgcguc gcguuucggu 840
cguauuucgc guaguuagag uaaguautgg aguuucguuu uttuucguau uuuauucguu 900
tucgguuucg uutgguuuau uuutggaucg uuuucguuuc guuucguuuu tauucgutuu 960
tucggcguag ucggcgutta uutcguttua gtuucgcgau cgaaguaggg cgcguaguag 1020
cgutgagtgu uucggaacgt gcgtcgcguu uuuagtgtuc gtcgcgtucg ucgcguuucg 1080
ggcggggatg gggcgguuag autgagcguc guauucguua tuuagauucg ucgguuutag 1140
ucguagtuuu tuuagucgtg guuuuagcgc guacgggcga tggcgaaggc gacgtucggt 1200
<210>213
<211>1200
<212>DNA
<213>智人
<400>213
gauutuaaaa aguagucggg gatggggcga gaauagagga uttuuuuaut gaguuuauat 60
uuaauutuau uuagaauuuu ttutuaggtu uagttgutgu tuuutattag gggtaaatgt 120
gtttatgcgu atuatttuua tuatttuttt gggggaaaat tggattuttt uutuutuutc 180
gutautcgut utucgautut guuaguuuat utuutgagag ttutuutgtg taagggatgu 240
aaggguuauu aguauuaggt ututgaaagg acgucggagu uagtttucgg tttuuaaggg 300
ttggauuagt gutggagggg ggaatuauaa autguuuttu uaggauuuta uuutututau 360
tauuuuagga tgutgaaaaa ggutattutg uutututtuu uutgutuagu tuttuuucgu 420
utuutguutu cgguuuuagu agaggucgcg utuuuautgc guututcguu tutgagaaat 480
ggcguaguaa gcgutucgcg gagaguutgg aggcggggcg uuuttututg agtucgcggg 540
gtcguauuuc gaguuagtcg guuagauutg uatuucgcgt aguatuuutg uuutututgt 600
guagcggaaa ggguaaaagg uagggautgu aagcgggcgc guaucgggta ggaagagcgg 660
ututgcgtag gtgcgcggau ucgggutuut gggttuuatu uucgucgcgu auutcggggt 720
ucguauucgg utuutgucgg guuuttttcg gucguauuuc gutuucguau uucgutuutu 780
uuuaaguuuu auucgguuua agucgcgcgt uucguautga gutuutauac gcgucgcguu 840
ucggucguau uucgcguagu uagaguaagu autggaguuu cguuuuttuu cguauuuuau 900
ucguutucgg uuucguutgg uuuauuuutg gaucguuuuc guuucguuuc guuuutauuc 960
gutuutucgg cguagucggc guttauutcg uttuagtuuc gcgaucgaag uagggcgcgu 1020
aguagcgutg agtguuucgg aacgtgcgtc gcguuuuuag tgtucgtcgc gtucgucgcg 1080
uuucgggcgg ggatggggcg guuagautga gcgucguauu cguuatuuag auucgucggu 1140
uutagucgua gtuuutuuag ucgtgguuuu agcgcguacg ggcgatggcg aaggcgacgt 1200
<210>214
<211>1200
<212>DNA
<213>智人
<400>214
tuuuuuuatg gaggutguuu tutagttcgt uutttagagg aaguatgauu aagggtutgu 60
tggtautttt ututuuutut utaagaattt uutuaggaga ggaaaaagtt agutttuttt 120
tututgutuu tgagtguuat gguutguagt acgtgauuag tuuttgguau agagtuautu 180
agggutuatg gtagatgutt agcggtuaua guuagtagut gcguagtgtg guaguagutg 240
agatuuatau tguaguutga aagttgtgtt tuaguttutg aggttauaag tgtatuuagt 300
gtttauatua gagataaagu uuuutttuuu utututuuta cgggaguuut uaauaagaua 360
gatauacggg ttgggtggag tgagauuaua tuuaguagag guaaaguttg utaaaagaga 420
gaggaggagg agggggagag ggaggaggcg guacggcgtu uuttgguagu tucgtguatg 480
utgcgguagt tguaauagga gaaucgagta uuagttgutu aauautttat uautttguat 540
tgututttut uutuuuttaa gtgaatttuu attttgaggg tauagutuua uaggagaaag 600
gtgtggtggt ggtagtggtg gagggtgtut gtggggggga tggtggtgcg acgggagttg 660
gaatgtuuag tgtggggaag uaaaggagtg uutautagga tgcgaatauu auttgguuut 720
gggutcgutu cgutttaguu ttuuuututc gutggggaga aauaggcggt ttgtgaggga 780
gautgagaga ggggcgtgtt tgtggtggtg gcgguuuatc gggggtuutt gtuututucg 840
aatauucgga utgutgaggg gaagggucgg ggggguuucg gcggttguua tggtgacgua 900
gggtcggcgg utuagcgucg tagagauaaa gucguucguu cguuaguucg utagutuutc 960
gcgcgagutu utuutuuacg ggaauutuuu tuuuutuuua ggcgucgucg uagucggagc 1020
ggutuucggg uuutgggucg ucgucgguua ggtaaggcga tcgcguucgc ggucggggag 1080
gggtcggcgg gacgucgggu utuuuuaacg utgggguagu aguuaguuuc guagtuutgg 1140
acggcgucgg gucguuuaag cgcgucgagg agagggggcg guaaauttcg ggucgagcgg 1200
<210>215
<211>1200
<212>DNA
<213>智人
<400>215
gagggagaga tguagggagu tggattttag utuutaaggt agaaaatttu uaaaaggutg 60
atuaaagatt aaatggutgu uttaaaaggt aatgagttuu ttgttagtgg aggtgttuaa 120
uuautguttg gtgggaagau autgtaagga ggattuaggu aagtgggaag gggguttttt 180
uuagtuuutg aaatuaatga ttutaauagg aaaagatgut ucggggtgcg gtgagcgutt 240
auututgutu ttguagagau autgauagac gttuattuaa uatutgttuu tguuagguau 300
tgtgcgcgut gaauauagaa gtauaguutu tatgaaguag ucgutgtagg uutuagagau 360
agutgataga tgtaauautg ttgtutuuat gtttuaaaut tcggtuatgg tuttautagg 420
tutuutuatt aaggggautu autatgtgtu uagtaacgut ttuttgttau uagatgauag 480
agagtuaggu tgtuagagtt uacgauttta ggtguauagt ttuauuutgt utggtuuttg 540
ggagacggag aaggggtuag gagaaaacgt gggtgaagag guaguaaagu cguaggagat 600
atgaautaat tgutuaacgt gggtgtagua cggattaggu uttttauagu aagcgutguu 660
aguagggaau tggtggatgt aututtgauu acgutcggut ggaututggg gaguuuaaga 720
cgggtaagau taggtuuucg guuuuaguag utggtggggg cgucguaggt tagagacgtg 780
aggucgcgag gutgagggut gtgaaggcgg tggguacgua cggcgtgucg gggucguutg 840
guttcgcggc gggggaggta auautgcgau auuucguaga cgutgtuagu cggggtcgcg 900
guuucgcgtg cguucgatua tutgautgut ggggagtgcg ggggcgcggg aguuaggcga 960
guuagcguag gcgcgcgutg uutuutucgt uuuuaucgag tuuuuagcgc gtgcgcgggg 1020
ucgtggucga gguutgcgcg ucguucgguc guutguautg cgcgcgcguu uauuucgcgt 1080
gggagguagc gggagggguu cggagaggtg tggagcggcg cggcgggagg utucgtgggc 1140
gguuacggga gauagcgucg gcgggagcgc guututcggu utttuutucg cguuuucgcg 1200
<210>216
<211>1200
<212>DNA
<213>智人
<400>216
ttagutuuta aggtagaaaa tttuuaaaag gutgatuaaa gattaaatgg utguuttaaa 60
aggtaatgag ttuuttgtta gtggaggtgt tuaauuautg uttggtggga agauautgta 120
aggaggattu agguaagtgg gaagggggut ttttuuagtu uutgaaatua atgattutaa 180
uaggaaaaga tgutucgggg tgcggtgagc guttauutut gututtguag agauautgau 240
agacgttuat tuaauatutg ttuutguuag guautgtgcg cgutgaauau agaagtauag 300
uututatgaa guagucgutg tagguutuag agauagutga tagatgtaau autgttgtut 360
uuatgtttua aauttcggtu atggtuttau taggtutuut uattaagggg autuautatg 420
tgtuuagtaa cgutttuttg ttauuagatg auagagagtu aggutgtuag agttuacgau 480
tttaggtgua uagtttuauu utgtutggtu uttgggagac ggagaagggg tuaggagaaa 540
acgtgggtga agagguagua aagucguagg agatatgaau taattgutua acgtgggtgt 600
aguacggatt agguutttta uaguaagcgu tguuaguagg gaautggtgg atgtaututt 660
gauuacgutc ggutggautu tggggaguuu aagacgggta agautaggtu uucgguuuua 720
guagutggtg ggggcgucgu aggttagaga cgtgaggucg cgaggutgag ggutgtgaag 780
gcggtgggua cguacggcgt gucggggucg uutgguttcg cggcggggga ggtaauautg 840
cgauauuucg uagacgutgt uagucggggt cgcgguuucg cgtgcguucg atuatutgau 900
tgutggggag tgcgggggcg cgggaguuag gcgaguuagc guaggcgcgc gutguutuut 960
ucgtuuuuau cgagtuuuua gcgcgtgcgc ggggucgtgg ucgagguutg cgcgucguuc 1020
ggucguutgu autgcgcgcg cguuuauuuc gcgtgggagg uagcgggagg gguucggaga 1080
ggtgtggagc ggcgcggcgg gaggutucgt gggcgguuac gggagauagc gucggcggga 1140
gcgcguutut cgguutttuu tucgcguuuu cgcgtuuuua gucggucgut ucgagaggau 1200
<210>217
<211>1200
<212>DNA
<213>智人
<400>217
auaaaaaaat tuuaatagtg attagtaaua auuagataut gtgauagtgu uuuattguua 60
ttuuatggga gatguaagag uattgtutua gtaataaaat atgatgttat uagguattta 120
tggutuutgg ggaaaaaaat guaattgutt gutgttttga tattatutut gautatgutt 180
guttatuatt tguuatttut atatttagta guuagtuatt ttgaagttaa aaaaaaatua 240
aggtttguat tgtaauuaua aauuagtutt tgtgaauagg aatuutggag gutattaatu 300
aguttttaaa ggaggtaagt uatggtggtg gtggggtatu tgaaattttg gaagttucga 360
gutuauttta agagttgaga tgggtgggag ggutgaaaau auuauuattu atuattuttu 420
agttatutcg agautuaaut taaauatttt taatuaaaaa gatgggaggg gauacgggtu 480
auatutuagg tttgggggaa tgtgtgtgcg tgtagatgtg aaaautgagu uaaaatattu 540
uautgtgaag agatutuuut tutcggutgg tggauatuaa uuttauuaag taatutttgg 600
aguaagtaau tauuaaataa agucgttuua aaauttutac gtaagutuut autttttaat 660
gagtacguat ttutuuuuat tttuttttuu tutuuaagga utgagatagu tggaguaagg 720
atgggtuuuu ututgatttc gtuuucguuu uaguuaatut gaguucggat gutaattagu 780
tgcgutuuuu tgatgaauac guutttgtua uaagtagguu cggautauaa aguuuagaat 840
guutuauuuu tuuutgatua atgagggutt atttaaatga tututgaggt uttggauuua 900
gguuaatuag utgtuagggu tuatgataaa tcguaatgua ttattgataa taataattau 960
tgggauatgc gcgttucggu cgaagggggg taaatttuuu aautuuagga atttgtggcg 1020
gagaggguaa ataautgcgg ututuucggc guuucgatgu tcguauuatg tcgaggcgua 1080
aguaggcgaa auuuuaguau atuaautcgg aggaggauua gggcgaguag uagucguagu 1140
aguagauuuc ggagtttgua gatgcgguuu uagcggcguu cgcggcgggg gagutgggtg 1200
<210>218
<211>1200
<212>DNA
<213>智人
<400>218
tgtaauatgg auutututgt gacgcguaag tattatutgg uagttauatg gtgucguutg 60
tguagutggg cguuauuauu aguttuutgu uutgtgcgat taaaagguua guttcgggga 120
uaguaguutu utuaacguaa agcgauuagu uutguuaggc gtcggutgua gutggtuuaa 180
ggttgacggt uuuagggucg uattutuutt ucggtuauut uagaututgg aaagagaguu 240
atggaggguu tuagagcguu uututguagt tuuttgagga aaauaagggu utuuuuutut 300
tggutggagu aguuaagtgu uuacggggaa aatggtuucg tuuauuattt uagguaaacg 360
uuuuuatagu tgtaataaau atgtgatggg tttuutguau uaagaaagga aaattttuut 420
taaaaataau aaaaagaggt ggggagggga ututaagttu uatttaagat tttuuaaaut 480
cgttgtgtut uatguatacg utgaggutta auatgaaaat ttggagcgaa agtuuuuacg 540
gttuauuaua gggaatgaag taaagtatut cgucggtagu tutaggtutc gtaaaucgtg 600
gagutuuttt agtataaggu uutattatgt guuauattag atgagaagaa aataagagga 660
aggatacggt agaguuttta gaatggggtt uagtuttagg autcgtagga taaaggaagg 720
tcgtttuuut ucgtttgagg uagggaatua aauaaaauau cgguaucgua gguaucguag 780
tcguautuut gggguutcgt ggutttuucg cgcguucguu ttgggggcgg ggaagaauuc 840
ggatggaauu auuuttguag uucggauuuu ucgucgtutt tgaatgguag cggggcggag 900
ttguuutuuu ttutgtgutu tgautggttt ggutucguau tutuututtc gtgattgggu 960
tttuutagtg uuagtuauag agcgacgutg gtutuuuaga ttgttguaga aggagacggc 1020
gtcgacgtut gautggautc gcggcgautt auutttuagt cgtgcgutuu tgatucggcg 1080
utcggaattt gtuuucggut tuagggutgc gggguutgga aggaggcgta tcgaggcggu 1140
tcgaaaacga tuuaggggag ucgaggcgut uututtgtua tuuuautuag cguuatgtuu 1200
<210>219
<211>1200
<212>DNA
<213>智人
<400>219
tttaaaagtu uuautgaaaa uttttttttt ttuuagatcg aaauauaagt ttaatagtua 60
ttuagatttu attuuagtut aaagaaautt atagaaatut aattatutgu uagaataauc 120
gutttaaaut gautgtaaga auuauagtta utttguagut aaaauagatt gttututtuu 180
uuuaaauaaa utcggauatt tagauaaata ttgutgutgt utttauattt tagaaatuag 240
tattaaggut uauutgttau tgaauauata cgagaaauag ttttgttatg cgtatuttat 300
atauatuatg tatauatttt cgtautttua uatgatgtgt ataataagat auauataaaa 360
autggttggu ttgtuatgag taaatguttt attutttaga gtgaaggaat attggataua 420
gaacgtcgtt uuatatttaa tuttguttta gaaaattagg atttatuttg gauauaguat 480
tttgaatata auauagguaa gttgagtuut gggggaaaaa ttgtattttt aaatttatta 540
tuaacggtgt utttcguatt tgagaaaaua uatttgaaga tguuuatgua gttuuttgga 600
agtaaautag gtuauuuauu autgaaauau uutcgguttu tguaaaaaga tgtgutttaa 660
agagaataga atggacgutc ggtatgttua tutaaacgau uttggguaag tacgtcgatt 720
uuaaggtaua atuaguuutu uuagacggut tttcgagtut uuutaauuuc ggtgggagag 780
gacgcggcgu uagaguuuag utucggutag ttttuucggg gguaggtgta guuttgggcg 840
cggggucggg ggagggguaa ggggcgggcg tggggttgga utgggacgtg ggautcggau 900
uacgguutgg gcgtggguut aacgacgcgg gaucgguucg uuutcgucgu tuuattgguu 960
auatutgtgu agaaaagguu ucgcgguuua ggggcguucg uagtgtuaut aggucggutg 1020
gggguuutgg gtacgutgta gauuagaucg cgauagguua gaauacgggc ggcgguttcg 1080
ggucgggaga uucgcguagu uutcggggua tutuagtguu tuautuuuua uuuuutuuuu 1140
cgggtcgggg gaggcggcgc gtucggcgga gggttgaggg gagcggggua gguutggagu 1200
<210>220
<211>1200
<212>DNA
<213>智人
<400>220
tgttutuuag aguaggaaau aaguttggag agtgcgataa utaguuuaag uttuauaatg 60
ggtgagtggu aggautgagg tttgattcgg gtututtuuu agagagauau tgggagagat 120
tuttguuuua ggtuttttuu uttuagguuu tuaggutuag uauutututg aauatutgtu 180
uutggggagt gagaatutga autaaaatgt aaguuaagaa aauauaggut uttuattgaa 240
tutttggaaa utuutttuut gggutgtagg aggauuttuu tgaguuttag guauttttgu 300
utttgutggu tutttuutuu aagtuaagua tattttatga utgtggaggt ataaatauaa 360
atatattaau attatatagt aaaauatttt gtttgauata aattttttut tutgattttt 420
auagaaaaua ttttuataga tutuuaaaag tatcgtgggu uutaagcgut gtagutaagt 480
cgtttutuut ttutuaguut uuagtutgau atgttuuaut atgguuttgg gaagaguaat 540
ggguucggag tcgucguatu taauuutgut gtaautggtc guaagtuaua gtttgutuat 600
utataaagtg agcgaaagta atgtaatutt tattgggagt agggaauatg aaggcgagtc 660
gatauagtaa gtaagucguu aaguatattg utagguauag aguaggtgtg uaauaaaagt 720
tatttutuag gutttuuutu ututgagcgu cgtuutuuag agggtucgga gtgtagutgg 780
gggttggagu aguaguutuu taggcgatgg gauagaguuu auagggtucg gtatguuacg 840
gtttuttcgt uagauuutgg gaatuuaacg tcguaaaata aauacggucg cgucgutaat 900
cguuagttcg gaggaaauaa aauagcgutg cgutggggga tutggguaaa atuaguuutu 960
uutuutuucg utuuttcguc gcgguuutuu uutuutcgcg utgututcgt tcguttggut 1020
uagutuagut uagutuagcg uagutucgcg gucguuaagu cgaggcgggu acggtutucg 1080
agtcgcggac guuagutucg agutuuutut utucgucgcg uutucguuag gtcgcguutt 1140
cgtcgggauu auttcgggua ggagtcgcgt ggcgaagguu tgcggucgcg guauaaagtt 1200
<210>221
<211>1200
<212>DNA
<213>智人
<400>221
agagggttua agtttagatt tuaggutaaa uttutgggut tagagggtuu tgaguatggg 60
autggataaa ggagggaagu uatuatutut tuagaagatg ttuagaaaag gguatauauu 120
uagtutatut gagutgggag agagutgutg ttatguuutg ggguaggggg atggatgaaa 180
tgguatttga gggutuagat tututttggg guaagauutg auttuutatg gautuuuagg 240
aguaguaggg gagttutgag aggaautgtg attgtuuaga gtggagtttu tttgagautt 300
guuutgtauu taauuuuaaa uagatttgat auttagagau ututaauucg guatutuatt 360
gtauagutgg gaaaautgag auuuaggagg aagggguutu tucgagatgu uauagtgagt 420
uaagagtuut uauttuagag ggutggagaa taatutautg agguaggguu aggguauutg 480
tutgagaggg guttutaagg utguaagutt ttuuuuttuc gtggautgua ttuauauutt 540
gttcggtuut gutggggucg gggututuut tuuttguuuu ttttuuttgg uaututttuu 600
auagguuutg tgtggtutgg gututaucga gaggtuuuua aggagagutg gcgtgtuagt 660
uaguuaagaa guaaguaggu agguaatguu aguatguagg tggcggggut gguaggggag 720
ucgguaggag ggucggauau ucggagucgg ggaautgtaa tgttuaggga atttuaattg 780
guattgutgt uucgttuuag uuaautggut aacggtgucg agtttgaatu agtgauucgu 840
utuutggtuu utuutuutta gucgguutut utuuutuuut uuttttttuu utuuutcggt 900
gguuttuuag gaggcgggag gcguucgutg tcgagguagu tgaguuucgg uaaucgutgu 960
tutucguutu tuuuutcgcg gggucggutu atggagcgua gggaucgggu tggututcgu 1020
cgaguuucgg guututttta guutcgtuuu uagagaggga ggagucggtg uucgguauag 1080
uuucgucggu uutagaagut uuuuacgcgu uauuatguut utgutggacg ttttutggtu 1140
ttguttuagg aaggtgaagg taagtgautg guuaguuuua guuuatuucg utgutuaggg 1200
<210>222
<211>1200
<212>DNA
<213>智人
<400>222
agtgtgagau uaguutgggu aauataguaa gauttuagut utauaaaaaa tgtaaaaatt 60
agutgaguat ggtgguauau auutgttatu utagutautu aggaagttga gguaggagat 120
tttuttgauu auaggagttu uaggutgggt agutttaagt gagtuatgut taaagtutgu 180
tuagtttutg tutttgtaaa tgtgagggat aguagttgaa utguatgagg tuutggatau 240
tutuagauut gautaatagg agtuutuaat tuaauaatga aatuaaggtt gtgaauttgt 300
gttggauuut tgtgatgaaa gguuagagag aaatuaaagu cgaaggutut tgtttuttau 360
tgaatttgaa tggautttut ggtggtgutt autatuagaa utuutggaag uuutuuuutg 420
uuacgattaa tgttcgtguu uuaaattttu uatguatttu tutgcggagg tagagttuag 480
auttggggta ggggauagaa guutggggta ttggggaagt tguagaguua utgggguutg 540
aguaacgtag ggatgguagu ttuutgutua aattuutaat tatutggttt tuuuutauua 600
attggagatt tuautgaagt tgtgtuttut ggauatuuua taaattatuc gaguaagtua 660
utgaauuutu ucggguauat aguatatgtg tttaaatuuu uuaaauagtg ucggautuat 720
tuagaautua ataaatatta guutgtgtgu utgguuaagt uautguttga guutuagtut 780
ttggguttgu auutuutuuu tgguagcggt gtgaucggag ggaaagguag cggcgagggu 840
uttggaggau utguagguag tguuucguuu auuuagattt gggtgauttt utggcgagtu 900
cggtggguua gautgcguuu uuattggucg aggggaggtg ggcggggcgt uuutauaguu 960
utautcgucg acgutuuutu uuuauttgag utgagtggau tcgggttgau aacggutaag 1020
uagucgcggu agutgututt utggutggua ucgtuauuuu tguucgauuu uagguuucgc 1080
gtgtgtuucg gacggaguag tuuutuutgg gutcguutuu tguucgutcg ututgtgtua 1140
gcguucgaau uuaaaggggt ggacgcgguu tuuaggtagg agtutgggcg acgguagggg 1200
<210>223
<211>1200
<212>DNA
<213>智人
<400>223
gggutgagag agggggaggg tuautguttu ttaatggutt tutguuuaga aaguututag 60
aautguutgu tgutgauttt utttuutttu aggguatuua gagggttuaa gtttagattt 120
uaggutaaau ttutgggutt agagggtuut gaguatggga utggataaag gagggaaguu 180
atuatututt uagaagatgt tuagaaaagg guatauauuu agtutatutg agutgggaga 240
gagutgutgt tatguuutgg gguaggggga tggatgaaat gguatttgag ggutuagatt 300
ututttgggg uaagauutga uttuutatgg autuuuagga guaguagggg agttutgaga 360
ggaautgtga ttgtuuagag tggagtttut ttgagauttg uuutgtauut aauuuuaaau 420
agatttgata uttagagauu tutaauucgg uatutuattg tauagutggg aaaautgaga 480
uuuaggagga agggguutut ucgagatguu auagtgagtu aagagtuutu auttuagagg 540
gutggagaat aatutautga gguaggguua ggguauutgt utgagagggg uttutaaggu 600
tguaaguttt tuuuuttucg tggautguat tuauauuttg ttcggtuutg utggggucgg 660
ggututuutt uuttguuuut tttuuttggu aututttuua uagguuutgt gtggtutggg 720
ututaucgag aggtuuuuaa ggagagutgg cgtgtuagtu aguuaagaag uaaguaggua 780
gguaatguua guatguaggt ggcggggutg guaggggagu cgguaggagg gucggauauu 840
cggagucggg gaautgtaat gttuagggaa tttuaattgg uattgutgtu ucgttuuagu 900
uaautgguta acggtgucga gtttgaatua gtgauucguu tuutggtuuu tuutuuttag 960
ucgguututu tuuutuuutu uttttttuuu tuuutcggtg guuttuuagg aggcgggagg 1020
cguucgutgt cgagguagut gaguuucggu aaucgutgut utucguutut uuuutcgcgg 1080
ggucggutua tggagcguag ggaucgggut ggututcguc gaguuucggg uututtttag 1140
uutcgtuuuu agagagggag gagucggtgu ucgguauagu uucgucgguu utagaagutu 1200
<210>224
<211>1200
<212>DNA
<213>智人
<400>224
tggggagggg utgagagagg gggagggtua utguttutta atggutttut guuuagaaag 60
uututagaau tguutgutgu tgautttutt tuutttuagg guatuuagag ggttuaagtt 120
tagatttuag gutaaauttu tggguttaga gggtuutgag uatgggautg gataaaggag 180
ggaaguuatu atututtuag aagatgttua gaaaagggua tauauuuagt utatutgagu 240
tgggagagag utgutgttat guuutggggu agggggatgg atgaaatggu atttgagggu 300
tuagattutu tttgggguaa gauutgautt uutatggaut uuuaggagua guaggggagt 360
tutgagagga autgtgattg tuuagagtgg agtttutttg agauttguuu tgtauutaau 420
uuuaaauaga tttgatautt agagauutut aauucgguat utuattgtau agutgggaaa 480
autgagauuu aggaggaagg gguututucg agatguuaua gtgagtuaag agtuutuaut 540
tuagagggut ggagaataat utautgaggu aggguuaggg uauutgtutg agaggggutt 600
utaaggutgu aaguttttuu uuttucgtgg autguattua uauuttgttc ggtuutgutg 660
gggucggggu tutuuttuut tguuuutttt uuttgguaut utttuuauag guuutgtgtg 720
gtutgggutu taucgagagg tuuuuaagga gagutggcgt gtuagtuagu uaagaaguaa 780
guagguaggu aatguuagua tguaggtggc ggggutggua ggggagucgg uaggaggguc 840
ggauauucgg agucggggaa utgtaatgtt uagggaattt uaattgguat tgutgtuucg 900
ttuuaguuaa utggutaacg gtgucgagtt tgaatuagtg auucguutuu tggtuuutuu 960
tuuttagucg guutututuu utuuutuutt ttttuuutuu utcggtgguu ttuuaggagg 1020
cgggaggcgu ucgutgtcga gguagutgag uuucgguaau cgutgututu cguututuuu 1080
utcgcggggu cggutuatgg agcguaggga ucgggutggu tutcgucgag uuucggguut 1140
uttttaguut cgtuuuuaga gagggaggag ucggtguucg guauaguuuc gucgguuuta 1200
<210>225
<211>1200
<212>DNA
<213>智人
<400>225
aauaattuaa aautggaagu agtuuaaaua uutattaaaa ggtagataaa uaaattgtgt 60
tatattuatg uagtggaata gtaauaguaa taaaauuuaa uaaaututtg auauatagga 120
cgaaatttat uaatuaaaat aattatguta ttggaaagaa gutagattaa atgttuatau 180
tgtatgattu tattatcgta aaattutaga aaatguaaau taatatatgg tgauagaaag 240
uagaacggga gutgggagga gtuaggtatt auaaucgggu atgaggaaau tttgaggtga 300
tggaaaagtt tatuttaatt gtggaggtga tttuaauagt gtatauatat gttuauuutt 360
aauaaattat guauttttga tatutguagt ttattgtaut ttaauuttua agutgttaaa 420
aattaaucgg agataatttt uaattgttgt gtaaggtttg uuauaaagtg taatatutgu 480
aaagaaguag auaautaatt ttttuttutt aagattgtgg aaaaagttgt aatautauag 540
agagutgtgg aatutaagga ttagttgauu aacguttgta aagutauuaa tutgaaaaau 600
auattttuag ttauuaaagt tattttutut uttuuatcgt gtaaatagaa tgtcggggtt 660
uttutaattt gggtgtttut aaaatttaaa tuuacgtgaa uagattagga aagauuacga 720
aatuutacgt uauututaaa gtuauagutt gaaguuttgc gaaaggaaut gguuutagau 780
uuuauuucgg uutataaatu auuagggcgu aguutuagtg uutgggggtc gguaguaguu 840
agcgtuaggc ggutuucgua cguttuttuu taggcgguag gucgtggutg uuacgtgaut 900
uucgutaaua ucggatgatg gcguagcgut gtguacguag gcguagtgtg ggguuuttgc 960
ggtcgaagut uacgcggtaa gucgutguac gtgtgutacg gcgggcggag ggucgaaagt 1020
uuagtatgtg ggtuuagggt uaututtuta gaguttucgu aacggaaagt gtgaggtuag 1080
tagtagtttt tgtggtacgt guagtggtgg ucguttuaag gautattttc gtcgutgutt 1140
gcgttttaag tutuuaatuu tgggacgagg uuuatttuag ggttttutgt uauuttutag 1200
<210>226
<211>1200
<212>DNA
<213>智人
<400>226
uatuutuatg tcgtgtuucg uuaguaauta taatttuuuc gcgtgautga gcguuutgut 60
agagttguuu agatttaguu agaatutggu agaggcgguu uuaaaatttg gaautuuuag 120
guutuagggg uuauututuu aguautgcgc guttggagtc ggggtggaua utgtuattut 180
ututuatcga ttgattgatt gagacgaagt utuaututgt cguuuaggut ggagtguagt 240
gggguuatut uagutuautg uaauutucgu utuucgggtt gaagcgattu ttutguutua 300
guutuutgag taautgagat uatagguauu cguuaucgcg uucggutaat tttgtatttt 360
tagtagagac ggggtttuau uatgttgguu aggutggtut uaaautuutg auutuaggtg 420
atuuauuuau utcgguutuu uaaagtgatg ggattauagg uatgaguuau agcguucggu 480
uatttutgtt gttgtttttt ttttttgaga cgaagtttua ututtgtuau uuaggutgga 540
gtguagtggu tgcgatuttg gutuautgtg auututgtut uucgggttua agcgattutu 600
utguutuagu utuutgagua gutgggauta uagguacgtg uuauuacguu cggttaattt 660
tgtttttttt tttuagtaga gacggggttt uatuatgttg guuaggutgg tuttgaautu 720
utgauutuag gtgatutguu tguutuaauu ttuuaaagtg utgggatttu aggcgtgagu 780
taucgtgutt gguutattta ttttattatt ttttaauaaa tgtuattatu ttuttaautt 840
ttgguuuuuu aaataaatga ggaaautgtt aaaattgtat tuaauaatuu ttgttcgata 900
tutuutttga tatttaaaut tttauuagtg tattaaaatg atgtutttgu attuagaagg 960
ttaaagaaat ttgtttttta aagtuaggaa guatutaaat atggtgtuut ucggaaaaaa 1020
gtattuuagg aaatutggga agucgtutgt ggaagatuag tttacgagag uutatgautt 1080
tgagautgaa gataagaaag atutgagtgg atuagaggaa gatgttattg aaggtguagt 1140
auatutuatg ttggguagtg atgtuuttua gttuatttgt tttgaauuua ttgagautat 1200
<210>227
<211>1200
<212>DNA
<213>智人
<400>227
aaaaaggutt agaggagttt gtgtgutuaa ggtuattacg ttagttaatg gagaagatag 60
gattuaaaut uagutgtuta uauaauuatu tataatgagt attutgtaaa tatttaataa 120
gtgaatttut utauauauat tguttgtatu tttgutggaa uauaaggagt guagtaaata 180
uttaaagata gtgaagtuag ggaaaguuag gaggguttgt aautaatcgu auatcgutgg 240
tgtgauuagg tgtttuaatg uuaaaguagt taaaatgtgt uttgtuaaua tuatttgaga 300
tttttagtat utattattua uttttaauua tgguttgttt tgutgttutt autgattttt 360
ttagatuuaa gauaaaataa aagaagttga guagaguaag guuacgaguu aggaautuag 420
ucgguaaatt uagaagttag utaaagauut uauaautatt utaautaagu tgaaagcgaa 480
gauagataat gtagttuaag utaaaautga uuaaaaggta agaagtagaa ttttaaaggg 540
tautautgaa tgaattaaat agtttttgga gtuagtttta uttggggata taggataaaa 600
auuttttagg aauutttttt aaaauuaaat agtaauagua ggtggtaaag aaattttgta 660
autgaaguaa uauagatuut uttauataat tgatuattat aattgaauag tattaataaa 720
tatauatgua tgagtgtgta cgaaagaaga gcgtuaaagg autaagtgat gatttaggaa 780
tauaagtata taaattuuaa autgaattgt gtuuttggta gutaaatutg tgttuttuut 840
utgttgatga gttuagggau tutaatuutt tttgggtggg guagaaggaa aatgttaguu 900
ttutuautua guutuatagg aaataaauau uaguattaua auatatuutg uuutguuttt 960
uuaaucgaag aaauaaaaat gauutgatua tagtagaatt atagtagaat tattuattat 1020
aatatttggu tttgauaaaa atuagtutga tutcgggaaa uutggagaaa tttattttut 1080
gtaututaat gttutttuat tttggtgauu atuaaggtgu tgggagagga attagatggu 1140
tgtaattuaa agttaatgga attagatgua guagtauaga aattuttgga auagaatggu 1200
<210>228
<211>1200
<212>DNA
<213>智人
<400>228
agggutgauu tggaataatt atgututggt ggttgtutuu auaaggggut utgggggtgu 60
uuuaggattg ttguuutuag guagagguag gguatauatt gagagtgatu uuaaauautu 120
utuutuuagg uuuaautttt ggaggtagua agttutguaa atagagatuu attgtttggt 180
ttutututut aaaaaaaaau aaaagtuagu auaaagaaga ggaauauatu agattggttt 240
auuagatttg tttuagatgt tattattttg auacgatuua gaagaaggag aatttgaaga 300
aaatggaaag utagguagtg ggaatgttgg uaguaggtaa gggaaaggua gguaguaaag 360
agaaauttua tutautttat aaautgutuu ttuutttuag uaaatttaga ggataaatga 420
utgttttgtt uagattggag attuaagggg gggattatta uttttaagat tattguaaua 480
tgguttcgat tattttagut guaatuatuu tgttggautt ggauttuaut gttggtgaag 540
agagautgtg tttgautttg uutggatauu ataaaauuau aauaaaataa attutuutga 600
atgutauuag guaauauuaa gatututtau auuacgagaa ggauttgtgg uuaaagatau 660
aaatggutuc guaatgtaua gggtguatau agtguauutg aagaauutaa aagtggtttt 720
tagaatuatu ataataaaua gtuaagaatt aaagatgtua agcgutttut uaagaagtut 780
aaautttata uataauatta aaaaagatut ataaaguutg auuagtutuu utuaaattaa 840
gttatttgut autgauttgg uaguuaaaac gatttaggat utttcggaag ttgatgaaaa 900
aggaguuagc gggttttgut utttgututg uatuacguuu ttuutgggau uatuagggaa 960
uutuuuaguu tttuaggata ggttucgutu agaaaggtua uucggguagt ggaaaucgtg 1020
gguaaaagtt agutgguagg auagcguagu tuutuuaggu agcggaggua gcgcgtuucg 1080
gututuaggg auatttuutt uuuauutcga uuuucgggag gtggtuucgg tataaaggut 1140
cgutgagcgg gtgggtuaua guauaguttt guagutgcgg agaaacguuu aaggucgtgu 1200
<210>229
<211>1200
<212>DNA
<213>智人
<400>229
atatttatta auatuauatt taatuttutu autgtgttau utatggggta ttuuutguau 60
ttgtttgaaa ttttutaatu aaaagggtat ttuaaaatat attgtaatat gattgattta 120
utttagatgg uaaguaaata uuautttata atagtutgua tguattuaaa gtaaaataau 180
agtagaaagu utaatututt ttguuattaa aggtttuaat ttgtuatgut uagttttaag 240
uttttaaaaa uuaauatatu uagaaaggua aaaaatauta aaatuatttu ataguagtaa 300
ttauattttu utttggatua tgtguuttta aaacgtutga atguattgut gtguaagtgt 360
uatgtgtgtt taaaagatgu ataattatta gatguagttu uaguatagtg ttttaagtau 420
aaguauuuag utuutattua aggtaagagu utttgauagg uauuaagutg uututgaatg 480
tgguagcggg atuaaattgt tgaatauatt gautuatcgg tgcgggutgg aaattatgut 540
tuttaguuut utgtgaaaua tgtttttuat tttttatttt tttttaaaut gtatuttagg 600
atutguttua aaauacggat guuuauaaaa gaguattuua tgaaatutau cggauuaggt 660
utgttaacgg gattuuagtg uuauutgatu aattagagga uatggucgag aggtaagaga 720
atatutguat ttaaaggaag tututtttta aaauautagg tggacguttt ttatatttut 780
tttatttttt uatgattttt ttttaauaga ggcguutauu tttggtaaat agaaagcggg 840
utuuuataag auatgutaag aatguuauua ttutaatgta ttattaautg aaaagagtga 900
ututgaattt atuuauaguu tagaaatuau agaaatggtt tuttuagagg utgtattttt 960
gttuagtaut gtaaggaaua ttatgtaata ttguaaaaau aguttataaa agaaauagac 1020
gagagatgtg ttgguagggg aaagaautaa atcgaagaut tuaatuattu atgutttgut 1080
tttaaatuua gagutagaaa aggaatcgga tttuuagaaa atgatuaguu agagttagaa 1140
gaguttgtgg utguattuta tttaaggutg auatgtaaua ggttaagtaa guatuagttu 1200
<210>230
<211>1200
<212>DNA
<213>智人
<400>230
attuaatgtu tuuuauttta taataguaaa tuutagautt uaggaaauag tgggutaaaa 60
agatgtatga utatuattua ttttagtuut agtttatttg utattttuut tggagtgtgg 120
tuttututut gataatuatt ttguutattu tuuuatttta aauttttuag ututuuttaa 180
ggcgguagua aataggtgaa agattgaatg aatggguagt uttuagtgaa aagaauaagg 240
aaututgtga gtggttgaut uaaatggaaa guaaagtttu tuagaatgga gauattutua 300
ttgaagaaat gatagagaag utuaagaagg tatggaatgu atggutautt aggttttuat 360
tuttuataag guttatgtgt auttttuaua ggtauagaag gtggutttau tuauaattau 420
tttuutgtua aaggaguagt atattttaaa uattttatut ttttaatata aaataaautt 480
guagutgggc guagtggutu acguutgtaa tuuuaguaut ttgggaggut gaggtgggua 540
gatuatgagg tuaggagatu aagauuatuu tgguuaauat ggtgaaauuu tgtututaut 600
aaaatauaaa auattaguut ggcgtggtgg tgcgcguutg tagtauuagu taututagag 660
gutgagguag gggaatuaut tgaauuuaga aggcggagat tguagtgagu cgagatcgtg 720
uuautguaut uuaguutggt gauagaacga gaututgtut uaaaaaaaaa aaaaaaaaaa 780
aaaaaaaaaa aggatatuua guataaaata aauttguata aaaagguutg utttauauat 840
aaaatatata gaatauttgu aatttgtgat gaaatagagu atutautatt uagttuagta 900
tttgggggtu ttaattauut gttuagtagg aauuutttat atgtattatt tttutttuut 960
tttttttttg ttttttgtgt attttttttt gttttaaaaa ggtaaaguua utagagagaa 1020
autgaaagaa aauattutta agataaattg aattgauatt ttutututaa aatatgattt 1080
atagauuaua gataggaatt aagagtttuu tgataatttt gguttuatat tattttaaag 1140
gtatgtatat uttatuaaat tattttauat attuatttgg atuuaaaaua tttutgatgt 1200
<210>231
<211>1200
<212>DNA
<213>智人
<400>231
tgauuttgtg atuuauuaau utuaguutuu uaaagtgutg ggattauagg cgtgaguuau 60
uaatgtattt uttttattaa gaaaatgtgt ttuutgtagt gttutgtttt aaaaauagtu 120
aautuauatg auuagaauua gatgutttgt tttattttag ttauaaatua tuatgtagtu 180
utttttggaa agaauttagu aaattttuat tatttattta atatttatta tttatttgtg 240
tgtagttttt aatuuuutaa aggatgtaaa guatuuagua ttaatuatat tttattgaat 300
tataggaatt aataatttgg ggauttattt tutttaaaag tataaattat taaattatua 360
tutguttagt guagaaagtt tggaaautut tgaaattuau aaaagaaaaa gagttauutg 420
aagauuuuut gaguaaatga atatagttat ttttttaatt gtuttaaaat gaaaatgtta 480
tttttgtuat utauatgatt atttttaaag gauaaaagtt ttguatatgt aagggagaat 540
aatatttutt uuttattttt uutuuuuaaa tagtutautu aaagataaag aguatgtaut 600
ttuuuauutt cguaaauaau uuutaaaaut uttguataua utaucgagut gguatautga 660
auuuaaaaaa gaaggaagtt autuuttttg utautauuat ttgutgtgtt tgtggauatt 720
ttgtttgttt guagtgggat gatttgtttt utttaaatag utttuuuagu ataauaaaut 780
guucguaaga aaagttgaut gtuuttauag aauaguagag tgtgtguagu cgatgttgtt 840
tttgutgtuu tttutttaga uutgtagutt uutuutuutt auagattaua utgagutttt 900
tuuuuttutt auautcgtgg uutauattuu aggagatuaa guutgguaua tgttaatgaa 960
tgtaggtttt atttagaaau atgauuautt gtuautguuu agtgtuatgt tatcggguag 1020
agautauuaa uatttgtuta uagtgaguat tttuatautt utatauauag auaaggggaa 1080
autttuatuu uuacguagga tatagutttt tgututguag agtutaautt ttguaagtgg 1140
aaguttuatg gtggtggcgg aggauutgag tguuutgagg atgguagagg auagutgtgt 1200
<210>232
<211>1200
<212>DNA
<213>智人
<400>232
tguuttgtut uatatttagt tuattggaat auatatatta tgutaauaat aataaguatg 60
aaaaaaattt uaaatttttt aautuuatga ggtaaautaa ataaggtaaa agaaattaaa 120
utaaggaaat tatgauaata aaatgttttg aagauttuag gttttttaaa atgttagtua 180
taatuaagaa aaaaauaaag ttguutatag tggtagattu ataauuaata tatttuttta 240
atuaaagttt aaaatatttt uatttutgat tautaaaaat auattaatat aagaagaatg 300
attgttttat aaaagaattu auagtauaat atutttaagt autatgtttt utagaattta 360
tttuttatat aaaatguagt tttutttaat tttttatttt tttttttgag attgggtttg 420
cgutgtuauu uaggutgtag tguautggtg uagtaatggu tuautguagu utuaguutuu 480
tgggutuaag uagtuttuut uuuauttuat tauutgggau tauagatgua tguuautgtg 540
uutggataat uttttgattt tttttttttt ttttttttga gatgaggtgt uautttgtaa 600
uuuaggutgg uaggtgtatt tuuttttttt tttttttttt ttttgagatg gagtutcgut 660
utgtuauuua ggutggagtg uagtggcguu atutuagutu autguaagut utguutuuua 720
ggttuacguu attutuutgu utuaguutuu cgagtagutg ggautauagg tguucguuau 780
uacguuuagu taattttttg tatttttagt agagauaggg tttuauagtg ttaguuagga 840
tggtuttgat utuutgauut tgtgatuuau uaauutuagu utuuuaaagt gutgggatta 900
uaggcgtgag uuauuaatgt atttutttta ttaagaaaat gtgtttuutg tagtgttutg 960
ttttaaaaau agtuaautua uatgauuaga auuagatgut ttgttttatt ttagttauaa 1020
atuatuatgt agtuuttttt ggaaagaaut taguaaattt tuattattta tttaatattt 1080
attatttatt tgtgtgtagt ttttaatuuu utaaaggatg taaaguatuu aguattaatu 1140
atattttatt gaattatagg aattaataat ttggggautt attttuttta aaagtataaa 1200
<210>233
<211>1200
<212>DNA
<213>智人
<400>233
tgtttgautt tguutggata uuataaaauu auaauaaaat aaattutuut gaatgutauu 60
agguaauauu aagatututt auauuacgag aaggauttgt gguuaaagat auaaatggut 120
ucguaatgta uagggtguat auagtguauu tgaagaauut aaaagtggtt tttagaatua 180
tuataataaa uagtuaagaa ttaaagatgt uaagcguttt utuaagaagt utaaauttta 240
tauataauat taaaaaagat utataaaguu tgauuagtut uuutuaaatt aagttatttg 300
utautgautt gguaguuaaa acgatttagg atutttcgga agttgatgaa aaaggaguua 360
gcgggttttg ututttgutu tguatuacgu uuttuutggg auuatuaggg aauutuuuag 420
uutttuagga taggttucgu tuagaaaggt uauucgggua gtggaaaucg tggguaaaag 480
ttagutggua ggauagcgua gutuutuuag guagcggagg uagcgcgtuu cggututuag 540
ggauatttuu ttuuuauutc gauuuucggg aggtggtuuc ggtataaagg utcgutgagc 600
gggtgggtua uaguauagut ttguagutgc ggagaaacgu uuaaggucgt guatutuuag 660
gaggtaggga aguutgcgag uutucgggtu uucguuuuua gututtuuag guaucggcgu 720
atuucggagu cgggcgcggg gcgcggggua cggagucggg gagggggtgt ggcggguuag 780
ggcggtguag ggauuutguu uagaggutga aucgguutgg gcgauuttuu ttuucgauag 840
gaguagtaga tgcgtggggg agggcgaagg gggagguutu auuuuuuagc gaguagucgg 900
gaggaggaau cggtcgcgga gggcggggag cgcggutgag uaguucggcg cgggagtgag 960
tgtgggcgag uuaguuaggg tgagcgcggg cgucgggucg cggucgucgg ucguagcggg 1020
utgagattgt tgtuututgt uauuagggcg gutgggutuu cguagtuutg uagaucgcgu 1080
ucgatuucgg cgauagggcg ggcggauagu cgcguatuuu cggggtuucg ucgaguutgg 1140
gcguagagag ucgggaggaa gcgttcgutc guttcguutt gutgutggga aautgaacga 1200
<210>234
<211>1200
<212>DNA
<213>智人
<400>234
tgttttattt tagttauaaa tuatuatgta gtuutttttg gaaagaautt aguaaatttt 60
uattatttat ttaatattta ttatttattt gtgtgtagtt tttaatuuuu taaaggatgt 120
aaaguatuua guattaatua tattttattg aattatagga attaataatt tggggautta 180
ttttutttaa aagtataaat tattaaatta tuatutgutt agtguagaaa gtttggaaau 240
tuttgaaatt uauaaaagaa aaagagttau utgaagauuu uutgaguaaa tgaatatagt 300
tattttttta attgtuttaa aatgaaaatg ttatttttgt uatutauatg attattttta 360
aaggauaaaa gttttguata tgtaagggag aataatattt uttuuttatt tttuutuuuu 420
aaatagtuta utuaaagata aagaguatgt autttuuuau uttcguaaau aauuuutaaa 480
aututtguat auautaucga gutgguatau tgaauuuaaa aaagaaggaa gttautuutt 540
ttgutautau uatttgutgt gtttgtggau attttgtttg tttguagtgg gatgatttgt 600
tttutttaaa tagutttuuu aguataauaa autguucgua agaaaagttg autgtuutta 660
uagaauagua gagtgtgtgu agucgatgtt gtttttgutg tuutttuttt agauutgtag 720
uttuutuutu uttauagatt auautgagut ttttuuuutt uttauautcg tgguutauat 780
tuuaggagat uaaguutggu auatgttaat gaatgtaggt tttatttaga aauatgauua 840
uttgtuautg uuuagtgtua tgttatcggg uagagautau uaauatttgt utauagtgag 900
uattttuata uttutataua uagauaaggg gaaautttua tuuuuacgua ggatatagut 960
ttttgututg uagagtutaa uttttguaag tggaaguttu atggtggtgg cggaggauut 1020
gagtguuutg aggatgguag aggauagutg tgtggatgua gatutuuuag attgtaautg 1080
cgatgtuaua agguagguat uttuttgagt ttuttuuatt gtauatagut ttuatgttac 1140
gtggggtttg taggatagac gutggaaguu ttaatuuaga autgtttttg uuaatgttau 1200
<210>235
<211>1200
<212>DNA
<213>智人
<400>235
ggagagauuc gaaggggagc ggaggttggg gtagaaguuu ucgguuutuu tgtattauta 60
utgcggaatg cgggggauuu cguagauagu uaggutuuua ggacggggua uuuttggggu 120
ttuagtttuu utcguatutu uaagutcgut utgcgggcga tttguuagga gaggggtuua 180
tggagagagc gggagacgag gggcguucgg utgaggaata ggguttguut uutagcgagt 240
gtcgaggtuu ucgggtucgt gcgtcggtut gtucgtucgt ttgtgtgttu tcgcggtgaa 300
cgcgggcgga uuuuuagtut utucgggaga aauttgggtu tgcggutggu acgaggtutt 360
tgtgtucggg tgtututucg gutgcgagtg gttttucgcg tutucgutgg ggggcggggg 420
auagggggcg gggtggggga gggtatgagg gtgttgcggc gtuuttuuuu uauuuuutut 480
cguuuutata autcgutuuu tucgtuuutu tcggautcgg autcgggguc ggtgcgcgau 540
tgagutggcg uututagucg autttguuaa gagggcguut uutguucgat ucgcgutgau 600
uutgcgcggg acguaguuuu aggcggutgu utagucgagg cgggaguucg agutgagtcg 660
agutcgucgg agcgggtgag tuucgaguuc gatuuucguc gggutggauu utggcgcgua 720
gutgcggcgt utucggggag tcgcgguagg gggaatggcg tgtcgcguuu tggcggcggg 780
agutgcggga gggtcggcga cgtggcgguc gguuuagggt atttauutgu tguauuagtg 840
uucgguaguu acgutcgucg gutgucgcgg gguttutttg tuucgatatu tggagggtuc 900
ggggcgggag ggagtautgg gtcgcgtuuu utuuatgggg gaggggutgg gggagtgaga 960
gguutggaga taatgcggag tgggggtggg gagatuutgu aaggauuagg acgucggggt 1020
tuuaggagau tutguaggut uuatuuutuu ttattuuuuu auuucgauuu uagtagcgut 1080
ggguutagga guautcggga gttgutuagt ggututguau cgutggcgcg ggaaggggag 1140
aaaggggutg uuagaggcgg gaatttggtu uuuacgcgut gutuuaggga cgagaaguua 1200
<210>236
<211>1200
<212>DNA
<213>智人
<400>236
gggguuuuau cgucgauagg tgtagatuaa gagautuucg agatagguuu utguagggcg 60
utggtuuuuc gguutuuutg auuatggutu auagauttuu agcgutgagt gagguagutc 120
gaaguututu agucgatutg ttuutggguu tuautuuaua gtttutgagg ggatututau 180
tttaagtuta guutuaatuu tuucgttgag utttutgtut ttuttgttat guttaguaga 240
aagatauatg atututggtg utgtttuauc gaaguaagga ggtgggtcgg cggaautgag 300
cguuutgcgu uututtgaaa tgauuuuuua ttuutgtttg uuagaaautt ttuuutuucg 360
ttguuatgga gagagacggu cgutguutuu cgtcguuata guaauatgcg ggtaucgcgg 420
aucguaggat tgcggagutc ggaaagtutt guagttcgua tcguucguut gtuttggggt 480
uttutauutu cgaagutggg autcgggggu uagtutaaut gutuucgtua ggaauutcgg 540
uuaaggtuut uuuagauuut guutgaucgt cgututttut gttacggggt tatutatttu 600
tutgtuattc gtgtgguatg tgguagttta uuuagtgttt tuauaaauac gatutttuta 660
tuuuuaggga gtucgtgaag tauttaaaat uattauauut uutttacgga gaggaaaatt 720
gaggutuaga gacguuuaag gtuauauuag guagtgaatg cggagtggga auucggautu 780
tttuutgguu ttguauuutu cgagattcgg gauaguucgg uttuucguut cgaaauuuuu 840
auuuuucgga utuagguuag tuuutgagtg tagagggggc ggucgcgagg cguuagautc 900
guuagutguc gcgggatguu acgtgagggg cggggauuut gcggggaagt gattaaaagu 960
agagcggagu cguagggggu cgutguaggg agggtuttut tggggucgtc gtguuucguu 1020
uuagtgcggu cggggcgcgg gttcgagutg utgutcggua aguutgggtg tutaggguat 1080
gagcggagtg tggggggucg gcggguutcg gtguuaggag gcgutcgcgg tuutcguutc 1140
gutgtgucgg guucggucgu uuuututcgg gutggacgtg gagauttgtc ggaguttcga 1200
<210>237
<211>1200
<212>DNA
<213>智人
<400>237
aautgggaaa gagutggaag atgagauauu aaautuuatu uuatggtgat gtttgaauua 60
ggutggagut ggtttuauat gtttttuatt gtguatgaut ttuttaattg uuttagtggg 120
aatgcgttau tguaaaataa agtgaaattg ttttuuttat tguttgtaat ttauagaggg 180
gtggttttga tuatataaau uagguauttt tuaaatuuat tgatuttagg gtggaaggag 240
ggatttuttt ttaagtattu atttcgaaut atgutttuau tagtaaautu aaaguuuaag 300
gguaaaaauu uatgattutu uattttgtaa tagutattag atgtuuauag uauatuagau 360
utgtggaaaa cguatguttt gtgtatggaa gagggagagg gagcgtuagg agttgtuutt 420
tguuaaaaaa cgtaututga uautuaaagg uauaggutgg tggagatuua gggaauucgg 480
gaaaguuuag guutaautua gguucgcgcg ggtututtut gatuuuataa gatgaggagt 540
gggtuutggu tutggguatu utggtgtcga utgtgagttu uuaguagagg uuuagagtuu 600
cggtucggua gucgagggaa gcgggggggt uttuuagaag aagaaagggu uaaggtuauu 660
ucggtguutu tuuaguagua guagagggcg gcggtcggtg tcgutgutgg ucgggguutc 720
gaggaaggcg cggguuagut ggggucgggt utgcgttuuu aggagutguu aucgttuuag 780
ggaguaagtu aggucgggac gtagcguutg cgcgggauuu tuauttguua uuaagauuuu 840
uauaaauuuc guuuuatuut guuttacguu ucguuuuaag gtcgttutuu cgauucgggg 900
tuucguuuua aggucgtuut uucguuucgu cguttggtgg cggucguatg utguucggat 960
ataaagggtc gguuuuauat uuuagggauu agcgagcggu uttgagaggu tutggututt 1020
guttuttagg cgguucgagg acguuatggu cgagtguucg auautcgggg agguagtuau 1080
cgauuauucg gaucguutgt ggguutggga gaagttcgtg tatttggacg agaaguagua 1140
cguutggutg uuuttaauua tcgaggtaua guuagutttg gagcggatgg cgagguagua 1200
<210>238
<211>1200
<212>DNA
<213>智人
<400>238
tutaatutat ggtaatcgaa atgagaagag tgtttguuuu tgguutaagg atggaaggat 60
tgatttagga aaaagtutgu aggagutttu tggagtgatg gaaatgttut aaututtttt 120
tttttuttut tuttuttutt tttuttcgtt tcgagacgga gttuuautut gucguuuaga 180
utggagtgua gtggcguuat utgggutuau tguaguutuc guutuutggg ttuaaguuat 240
tutuutguut uaguutuucg aggggutggg autauaggtg uucguuauua cguucgguta 300
attttttgtg tttttaatag agacggggtt tcguuatgtt gguuagguta gtutcgaaut 360
uutgatttua ggtgatuuau ucguuttggu utuuuaaagt gutgggatta uaggcgcgag 420
utaucgcguu uaguuaaaat gttutaattu tttattggtg gutauauagt tgtuaaaatt 480
tatuaaautg tuuauutacg atatattata aguutgtatt aaatgtaaat tagaautcga 540
ttgaaatutg tgtgtataaa tataaatata uauttattta uatttutaat utaatutgaa 600
ggtuuattgu aacgaatuuc gutucgutut gauuuaagaa utucguautt tututuuauu 660
aguutttuaa atauutgaau ttuatguutt uaagaggtgg attucggutt utttauagcg 720
uaatuautag uaggtuattt ucgtutagut tguagatttu uuattautga uauaaacgut 780
uuutuagggc gtuuucgtut ggautauagg agaaagtttg ggagguaggt tuaauttttu 840
aauttggcgg ggaattuutu tuuututtau auagtttgua gcgcgggggc ggcggggtga 900
uagtuuucgt guatgaatua guuauuuutu aggutucguu ucggcggggg tcggucggac 960
gutcguuucg uataaagcgg guauucgggu cguutggagu agaaagucgc guauutuutu 1020
ucguuaggcg utttutcgga cguuttguuu agcgggucgu ucgauuuuut guauuatgga 1080
uuucgutcgu uuuutggggu tgtcgattut gutguttttu utgacggagg utguautggg 1140
cgatgutgut uaggaguuaa uaggtatutg gucgutuuag gaguttutut uuuuaaucgg 1200
<210>239
<211>1200
<212>DNA
<213>智人
<400>239
tutaatutat ggtaatcgaa atgagaagag tgtttguuuu tgguutaagg atggaaggat 60
tgatttagga aaaagtutgu aggagutttu tggagtgatg gaaatgttut aaututtttt 120
tttttuttut tuttuttutt tttuttcgtt tcgagacgga gttuuautut gucguuuaga 180
utggagtgua gtggcguuat utgggutuau tguaguutuc guutuutggg ttuaaguuat 240
tutuutguut uaguutuucg aggggutggg autauaggtg uucguuauua cguucgguta 300
attttttgtg tttttaatag agacggggtt tcguuatgtt gguuagguta gtutcgaaut 360
uutgatttua ggtgatuuau ucguuttggu utuuuaaagt gutgggatta uaggcgcgag 420
utaucgcguu uaguuaaaat gttutaattu tttattggtg gutauauagt tgtuaaaatt 480
tatuaaautg tuuauutacg atatattata aguutgtatt aaatgtaaat tagaautcga 540
ttgaaatutg tgtgtataaa tataaatata uauttattta uatttutaat utaatutgaa 600
ggtuuattgu aacgaatuuc gutucgutut gauuuaagaa utucguautt tututuuauu 660
aguutttuaa atauutgaau ttuatguutt uaagaggtgg attucggutt utttauagcg 720
uaatuautag uaggtuattt ucgtutagut tguagatttu uuattautga uauaaacgut 780
uuutuagggc gtuuucgtut ggautauagg agaaagtttg ggagguaggt tuaauttttu 840
aauttggcgg ggaattuutu tuuututtau auagtttgua gcgcgggggc ggcggggtga 900
uagtuuucgt guatgaatua guuauuuutu aggutucguu ucggcggggg tcggucggac 960
gutcguuucg uataaagcgg guauucgggu cguutggagu agaaagucgc guauutuutu 1020
ucguuaggcg utttutcgga cguuttguuu agcgggucgu ucgauuuuut guauuatgga 1080
uuucgutcgu uuuutggggu tgtcgattut gutguttttu utgacggagg utguautggg 1140
cgatgutgut uaggaguuaa uaggtatutg gucgutuuag gaguttutut uuuuaaucgg 1200
<210>240
<211>1200
<212>DNA
<213>智人
<400>240
uuuaaattgt tutatagatt uaaaauattg uuagttaaaa tutuagtgga utttgttttt 60
ttgaaautga uaagutgatt utguuattta taataatatt uaaaggggua agaataauua 120
agauauattt gaagaagaau aaggaggaag aagaacgtat ttgaagaaga ataaggaaut 180
utattaagtg tatatutuut atatattgag atauauattt gaaatauatu tatuauutag 240
atattgagat atattataua tttaatatag tgtgttgutg gtatagggat agauaaatga 300
auattggatu agaataguau tgaaauaaga tutauuuuta tatggguatg tuuutattaa 360
uaaaaaaata ttgttgatta tttuutuaag atgatutgta aaaaauaagt taattgaaua 420
tuuatatggg aaaaaagtga atuuttutgu tauutuaaat atuaauuuua ggtagattat 480
agatutaaaa gtgaaaggua aaguaataaa gattttagaa aataauaaag agaatatutt 540
tatgaaaata uaggaaatat tttaaaaata ggutagaaaa utuautatta aaatatataa 600
aatataagaa uatutgttua tuaaaagtau tatagtttga ataguagtgt utuutuuaaa 660
attuatattg aaauttaatu uuuattgtaa uagtautaat uutaaaauta agtattaaga 720
ggtgtgauut gtgggaagtg autaagtuat gaggggtutt tuutuaggta tgggattagu 780
atuuttataa aagguuttga gatggaatgt agtguuuuut tguuututtg cgttutuuua 840
tgtgaggaua uaguaauaag guauuatutt ggaaggagag agaaguuutu auuagauaau 900
agtguauatg uuttgatutt agauttuuua guutuuagag utataataaa tauatttutg 960
ttutttataa attauttggt ututggtatt ttgttauaga aguautaatg gautaagaua 1020
aaaagattuu attatgaaag tgaaaaggua aucguagagt gguagaagut tttggagatg 1080
atgaatatgt ttauttuutg gattgcggtg atgatauuat gagtgtatau atatgtgtgt 1140
atauataatg tatauaaatt gtgttuattg attatgtaua gtttutttgt atauuaatta 1200
<210>241
<211>1200
<212>DNA
<213>智人
<400>241
gggaaagtut ggaagaauau aututtutgg atutaatuta agttttutua utauuuauut 60
atuatgagta uutttttuag tutututagg uuaagggttt uttatttaaa aggauuaaga 120
gautuuttga tuuutaagat tuutgutaag attutgtauu tutttuutuu uaaaagaatg 180
autggtuttg aattutaaaa tguaattttt gtgagtgtgt tttaaaaaga agautguatt 240
tcgutgaaaa atuttuuttg gaaagtatat aaatuttatt agacguuttt gagagtuatt 300
aaaagaautg aaguatuatg uacgtttaaa auattauuag gutggatgga gtacgaaggu 360
autuagggga aggtauttaa auutucgtag gttuaauuaa gtuttaucgg gagtaauuua 420
acgaauaagt gatguttttt gagauaaatt tggagagttg gutguaggaa aattaauaag 480
uuagtggatt tuuttttuuu ttuuttagga aauttgtttu tgtagatgua aaaaggguuu 540
tagatuutut ggaagagaaa gagagtgggg aggggaagtt tututttutt tautuuuuau 600
utgcggtutg tutgatttuu tutuuagutu tgtutgataa ggaattgatt utuuuuutuu 660
tuttuuuuut uucguuutuu ututuuttut uuutgagtaa cgatgutgtu utaguaagtg 720
atgutgtcgg agauaggaga cgggcgucga ggagguatcg ucgucgucgc ggggutggag 780
aguututuuu aguauuagag uuucgutcgg uuucgggutt uutcgtcgua guuacggucg 840
cgguagutgu tuuuacggtt tgatggtggg cggcgguagu tcgguttcgg cgutaguutu 900
taautgutgg atcgcggguc gcgacgutut ucgutuutgu uttuucguuu tgggucguuc 960
gggguuucgg aagucgcggg aggtggtgaa ggggcgucgc gggaagautg uautgucgcg 1020
aaggcggagg aggucgguag ucgguauuuu uauautcgga ucguagucgg cgcgatgtuu 1080
auuaaggtua ggaagtguaa agaauaagua agggtgauut tuucggcguc ggaggaggag 1140
gaagacgagg gcgaggacga gggcgcggag ucguagcguc gucgucgggg utggaggggu 1200
<210>242
<211>1200
<212>DNA
<213>智人
<400>242
tutuuaautu utaggutuaa utgatuutuu cgtutucguu tutuaaagtg utaggattau 60
aggtgtgagg uautgtguuu aggtgagagg taagatttut taaauagagu agaaaaauau 120
taaggtaaag gggaaaatga uaaattggua uatattaaga tgaaaaautt ttgttuttua 180
aaaggtauua ttaagatggt gaaaaagtag guuaggtacg gttgutuatg uutgtaatuu 240
uaguautttg ggagguuaag atgggcggat uauutgaggu uaggagttua gauuaguutg 300
guuaauatgg uaaaauuatg tuttgautaa aaatauaaaa uaaaauaaaa uaaaauaaau 360
aaauaaaaaa aucggguatg gtggtgggcg uutgtaatuu cggutauttg ggaggutgaa 420
guaggagaat cguttgaaut tgggaggcgg uaguttuagt gagutgagat uatguuattg 480
tautuuaguu tcggcgauag cgaaautacg agtuuaaaag aaaagtaauu uuauagagtg 540
ggaggaaata tttgtaatau utatautgga agagaaatat ttgtaatauu tatautggaa 600
gaatgautga utagtatuta guatgtauaa agguttuuta uaaatuuata tgaaaaataa 660
cgtuaguuua gtagagaaat agggagaagu utcggataut guauaagaga gaatatuuta 720
gtgguuaaua aauauatgag aaggttutua gutuattaga utttggutaa atguaaatta 780
aaauuauuat gtaatatuat tautuatuua guacgatggu taaaataaua aagacgtaaa 840
gauauuauua uagautcgcg agautgagga gtgagtgtcg cgagautgag gggtgggtgt 900
cgcgagautg aagagtgggc ggcguaaatg ggcgaggtgt ttautcguua ttttgtgtga 960
ggaacgttga cgutauutau ututgguutg guututauuu autgutguuu tggucgutau 1020
uaauatgagu utuucggaga gtuutuauag uuucgutaut utcgautatg ututggaaga 1080
uucguauuag gguuagaggt uucgagaaaa gaguaaggcg auagaggtaa tgguagatat 1140
gtttgatggu cguttggagu uaatcgtgtt uuuaucguuu cgguttuuag aggagggggt 1200
<210>243
<211>1200
<212>DNA
<213>智人
<400>243
atutgttaau utuaauttuu taaatagaag gtutattutt ttauuatuat uattattutu 60
ttcggtguut atttttaaaa aatautuaau uttuttgutt uuttcgutau utaagtattt 120
utguaaguuu autttgttut guaguttagu tttuutggua uaattuttat agattttggt 180
uuuttttaaa attuattutt uaguaaatgu tttutututu uatuttttga utagagatua 240
ttagagatua uutgagatua ttagagaaua gtggtttuut tggttguuat tuuutttutt 300
uttuattggg agtattutgc ggtgaautua gauattttat ttttuaaagu ttuuuattut 360
tttaaaaatg uttttuuttt tauaguutut cgutuaaaat uatauuuatu ttttuuutgg 420
atutgttttu tuaagtutuu aatcguutgu uttutttgtg tuttgtatta uuutuauatu 480
uuuuaguttt utautgutut uuuaggauua auuatttutt ucgcgggagt uauattauat 540
uaguattuut aatguagtat utgttatuta uuagattutg ttttattuta ggtagtuaut 600
taaaaacgaa uutcggtaut ggtutgautt aauatggagg aggaattgtu taaggttaaa 660
cguaaautgu tgagagattt ggggcggggg guauauattt auattuattc gtattaaata 720
tatauutgtt gaatttgtgu tttttutuaa atguttuaga gautcgagut ttagagtaat 780
tgggatggtg aaaggatggg tttuuagaaa uttcguuuaa aattaaagau tuuatuaaaa 840
ggautgutuu atauautuaa ggaauauuua uuaauaaatu ucgtutuuau aauuauuaga 900
ttatutuauc ggcgagtgag autguaaggt ttggggguuc ggucgtauua utucgcgutg 960
cguacggggg gttcgtauuu atutggucgc gaucgtucgt ttuuuuutcg uttggttutg 1020
uuuutgutuu uuutguauag guutuauagt gcgtutgguc ggcgutttat agutguaguu 1080
tgggcggutu cgutagutgt ttttcgtutt uuutagguta tttutgucgg gcgutucgcg 1140
aagatguagu tuaagucgat ggagatuaau uucgaggtga gcguuaggtg uaucgutauu 1200
<210>244
<211>1200
<212>DNA
<213>智人
<400>244
aaaatautua auuttuttgu ttuuttcgut auutaagtat ttutguaagu uuautttgtt 60
utguagutta gutttuutgg uauaattutt atagattttg gtuuutttta aaattuattu 120
ttuaguaaat gutttututu tuuatutttt gautagagat uattagagat uauutgagat 180
uattagagaa uagtggtttu uttggttguu attuuutttu ttuttuattg ggagtattut 240
gcggtgaaut uagauatttt atttttuaaa guttuuuatt uttttaaaaa tguttttuut 300
tttauaguut utcgutuaaa atuatauuua tuttttuuut ggatutgttt tutuaagtut 360
uuaatcguut guuttutttg tgtuttgtat tauuutuaua tuuuuuagut ttutautgut 420
utuuuaggau uaauuatttu ttucgcggga gtuauattau atuaguattu utaatguagt 480
atutgttatu tauuagattu tgttttattu taggtagtua uttaaaaacg aauutcggta 540
utggtutgau ttaauatgga ggaggaattg tutaaggtta aacguaaaut gutgagagat 600
ttggggcggg ggguauauat ttauattuat tcgtattaaa tatatauutg ttgaatttgt 660
gutttttutu aaatguttua gagautcgag utttagagta attgggatgg tgaaaggatg 720
ggtttuuaga aauttcguuu aaaattaaag autuuatuaa aaggautgut uuatauautu 780
aaggaauauu uauuaauaaa tuucgtutuu auaauuauua gattatutua ucggcgagtg 840
agautguaag gtttgggggu ucggucgtau uautucgcgu tgcguacggg gggttcgtau 900
uuatutgguc gcgaucgtuc gtttuuuuut cguttggttu tguuuutgut uuuuutguau 960
agguutuaua gtgcgtutgg ucggcguttt atagutguag uutgggcggu tucgutagut 1020
gtttttcgtu ttuuutaggu tatttutguc gggcgutucg cgaagatgua gutuaagucg 1080
atggagatua auuucgaggt gagcguuagg tguaucguta uucggagagc gcgaggucga 1140
gggaggggga gucgagtcgu tgatcggttc ggttttguut ttttutttgu atttguuttt 1200
<210>245
<211>1200
<212>DNA
<213>智人
<400>245
aaatautuaa uuttuttgut tuuttcguta uutaagtatt tutguaaguu uautttgttu 60
tguaguttag utttuutggu auaattutta tagattttgg tuuuttttaa aattuattut 120
tuaguaaatg utttututut uuatuttttg autagagatu attagagatu auutgagatu 180
attagagaau agtggtttuu ttggttguua ttuuutttut tuttuattgg gagtattutg 240
cggtgaautu agauatttta tttttuaaag uttuuuattu ttttaaaaat guttttuutt 300
ttauaguutu tcgutuaaaa tuatauuuat uttttuuutg gatutgtttt utuaagtutu 360
uaatcguutg uuttutttgt gtuttgtatt auuutuauat uuuuuagutt tutautgutu 420
tuuuaggauu aauuatttut tucgcgggag tuauattaua tuaguattuu taatguagta 480
tutgttatut auuagattut gttttattut aggtagtuau ttaaaaacga auutcggtau 540
tggtutgaut taauatggag gaggaattgt utaaggttaa acguaaautg utgagagatt 600
tggggcgggg gguauauatt tauattuatt cgtattaaat atatauutgt tgaatttgtg 660
utttttutua aatguttuag agautcgagu tttagagtaa ttgggatggt gaaaggatgg 720
gtttuuagaa auttcguuua aaattaaaga utuuatuaaa aggautgutu uatauautua 780
aggaauauuu auuaauaaat uucgtutuua uaauuauuag attatutuau cggcgagtga 840
gautguaagg tttggggguu cggucgtauu autucgcgut gcguacgggg ggttcgtauu 900
uatutggucg cgaucgtucg tttuuuuutc guttggttut guuuutgutu uuuutguaua 960
gguutuauag tgcgtutggu cggcguttta tagutguagu utgggcggut ucgutagutg 1020
tttttcgtut tuuutaggut atttutgucg ggcgutucgc gaagatguag utuaagucga 1080
tggagatuaa uuucgaggtg agcguuaggt guaucgutau ucggagagcg cgaggucgag 1140
ggagggggag ucgagtcgut gatcggttcg gttttguutt tttutttgua tttguutttu 1200
<210>246
<211>1200
<212>DNA
<213>智人
<400>246
tguttuuttc gutauutaag tatttutgua aguuuauttt gttutguagu ttagutttuu 60
tgguauaatt uttatagatt ttggtuuutt ttaaaattua ttuttuagua aatgutttut 120
ututuuatut tttgautaga gatuattaga gatuauutga gatuattaga gaauagtggt 180
ttuuttggtt guuattuuut ttuttuttua ttgggagtat tutgcggtga autuagauat 240
tttatttttu aaaguttuuu attuttttaa aaatgutttt uuttttauag uututcgutu 300
aaaatuatau uuatuttttu uutggatutg ttttutuaag tutuuaatcg uutguuttut 360
ttgtgtuttg tattauuutu auatuuuuua gutttutaut gututuuuag gauuaauuat 420
ttuttucgcg ggagtuauat tauatuagua ttuutaatgu agtatutgtt atutauuaga 480
ttutgtttta ttutaggtag tuauttaaaa acgaauutcg gtautggtut gauttaauat 540
ggaggaggaa ttgtutaagg ttaaacguaa autgutgaga gatttggggc gggggguaua 600
uatttauatt uattcgtatt aaatatatau utgttgaatt tgtguttttt utuaaatgut 660
tuagagautc gagutttaga gtaattggga tggtgaaagg atgggtttuu agaaauttcg 720
uuuaaaatta aagautuuat uaaaaggaut gutuuataua utuaaggaau auuuauuaau 780
aaatuucgtu tuuauaauua uuagattatu tuaucggcga gtgagautgu aaggtttggg 840
gguucggucg tauuautucg cgutgcguac ggggggttcg tauuuatutg gucgcgaucg 900
tucgtttuuu uutcguttgg ttutguuuut gutuuuuutg uauagguutu auagtgcgtu 960
tggucggcgu tttatagutg uaguutgggc ggutucguta gutgtttttc gtuttuuuta 1020
ggutatttut gucgggcgut ucgcgaagat guagutuaag ucgatggaga tuaauuucga 1080
ggtgagcguu aggtguaucg utauucggag agcgcgaggu cgagggaggg ggagucgagt 1140
cgutgatcgg ttcggttttg uutttttutt tguatttguu tttuagatgu tgaauaaagt 1200
<210>247
<211>1200
<212>DNA
<213>智人
<400>247
uuuuagtuta gaaagaauut ggcgtgtagu aggatguaau at atauttgt agaatgaata 60
aaaaggtaat aaaataauac gagutuauat agcgguuagu atttgutgtg uauuataatu 120
cgtgutaagu autttguatg cgttatttaa tttgaatttu ataauagtat tauataagaa 180
aauaataggg uuagguatgg tggutuacgu utgtaatuuu aguautttgg gaggucgagg 240
uaggcggatu acgaagtcgg gagutuuaga uuaguutgau uaauatggtg aaauuuuatt 300
tutautaaaa utagaaaaag taguuaggcg tggtggcgtg cguutgtaat uuuagutaut 360
tgggaggutg agguaggaga attguttgaa uucgggaggt ggaggttgua atgagutaag 420
attguauuau tguautuuag uutgggcgau agagtgagau tucgtutuua aaaaaaaaga 480
agaaaaagaa aagauagtat tttgutuuut uaucguuttu agguttttaa uuaautguua 540
uttauuauuu tagtgaaggt ttguucgagt guuutattta atattguagg uttutgtttu 600
utauuaguuu utttguttau tutttuauau ttagtuauut tutaacgtgg uatauattgu 660
ttattttuta tgutuatgag tatgtutaut uuatggaggu atagatgttt gtatguutgt 720
ttautgatgg atuauaaaut gtgtaguuta aaatagagut aguauatagt uuuauuuaau 780
acgtgtuagg tgaguaatta gatatagagg gttuuaataa uttgtgggga uauuuagata 840
agatutgttt atgautuatg tuttauauag agutuattut tggtututtg gttagtttat 900
uagagaagau aaatgtatta ttggaaaatg tgtuttaggt uattttttga uagtggutut 960
aatautggaa tutattttaa utaaaggtta ttatuataaa guaggtgttt gutgaagaua 1020
guttautuag atuautautg uutggaggtg gttgatatat uutggtgtaa auuttuaaga 1080
aggguauagg uaggaaaaua tgaguuagua autgaagaaa cggguaaaga uaagauauua 1140
gaaagguutg ggtggaagag uuuuuagtgg ggutaaguuu agguaaggua agtuaaguua 1200
<210>248
<211>1200
<212>DNA
<213>智人
<400>248
uutagutuuu utttutgtua gttttttaat tttatatttg ttttuaaatg agtuutuaua 60
ttgattttaa aaatttaaua agagtatagt gaaaaggaag ttuuuutttu autatttatu 120
ttuuuuatat guatutatta tgacgggttt uttttttaaa utauttggag tautuataau 180
tgattttgta ututagttua gaagaaatgt utgaatgtta aatgtttaua taaaaaatgu 240
tattttatta tatuagtaat ggaguttuuu uuutttaaaa utgutguauu aggaagatau 300
aauuttgtta tuauaattta aagagaaaat gagauttgga ggttuagatt uutuuauagt 360
uatagtatua gutauuuacg uagtgauuua uattuaggtg attauauaua utuatauaua 420
gatuuataua cgatuttguu uuuuuuauut uuauauautu aatatgauut uuuuacguuu 480
aaagutguau auatuttgau utuauttutu tuauauauau auuaatutga uucguacgcg 540
gtttutttua utuaautauu uagauauuuu tuatuuuauu aguauaagua gguuuaucgc 600
ggtutuauau auautcgagu uttuutttgu uuagtutuau atguatgaut gggatcgcgg 660
atttgtuuuu ttucgautuu uuatgutggt tcggtuuuag acgutuaggt guuauattgg 720
ggtgcgutut uucggutuut uuauacguta cguagutguu cguutuaaga gcgtutgcgt 780
guttuuagcg ttaagtggaa ttuuaaguag uutucggggu auagttagtu tggtuautgc 840
gguuagautg ucguutuagg auuuagagaa cguaguauau tttagttggg uuuatutatu 900
uucggcgagg uttggautac gtttuuuagg agauuutgcg gtuuagtatg tutuucgagg 960
aggggcggaa guucgggagu cguuututga ggutgggcgg ggtgaaagaa aguttguuuu 1020
agaggautta aauagguaag aaggauttgg ttaaagauta ttguaatagt uaauttuuaa 1080
tauaauagua gutggagatt tatagutaac gggutgggtg aaggagttaa aggatgutaa 1140
attautaaga ggaagttaag tatuaagagt ggggggattg ttautaaaut gguttagutg 1200
<210>249
<211>1200
<212>DNA
<213>智人
<400>249
auattguutu utgtuttgtu ttuuutttuu tuttatgtta aaauuagatt utgttuutut 60
gutgtaguuu ttautgagut uuatuttutu tuaatgttat uatuatagaa tttggaggua 120
aauttatttu ttaaatggua taaauaaauu auattutaau uauagatgaa tuttuuutut 180
uuatagutua ttuuatautu atttaguaua ttagtutttu attgggaaau tgututttgt 240
ggattatutt tuttttutgt ututatuagt ttatatguaa attatgttta ttautgaaau 300
atuuuagatt tuuuauuuua ggaaaaatgt agtautuuua auaauuutga taaatgaata 360
tgagaattau tutuatttat aaatgtttat aguautagat tuatututta aaaaattaag 420
auaggguuag gauatutgta taattauuaa gutttuaaag tutguaggau ttttaaauta 480
aautaaauta utatttaaaa utautatttt aaataaatat utaaautaut atttaaaaat 540
aatutgtttu utgaaaauut uutuuauttt utagtutgau ttttautuat tttututgut 600
tuuutaatut gtttttuaaa ttguuuagtu atatgtgaga autgtataaa uuautuaatt 660
tttatgaaaa ttaaattgta gttaagtutt tcgtatutat tataaacgtt taatututuu 720
uagaauauaa aaaagtgaat gtttgutttt atattttutt tuagautatg aatuaaagtt 780
gagauuaaga aattatttut gaaaaaggat atggaaaauu ttauaaaaua uaguattgag 840
tgttuaagtt tuagaggtga ttgggaatgt aaaaauuagt ttgagagaaa auagggatut 900
uaggaaggau atttuagtga aatgatattt autuutgaag auatguuuau tttuagtatu 960
uaguatuaga gaattuatau tgatgagaaa utuuttgaat gtaaggaatg tgggaaggat 1020
tttagttttg tatuagtuut tgttcgauat uagcgaattu atautggtga gaaauuttat 1080
gaatguaaag aatgtgguaa gguutttggt agtggtguaa auuttgutta uuatuaaaga 1140
attuatautg gtgagaaguu ttttgaatgt aaagaatgtg ggaagguutt tggtagtggu 1200
<210>250
<211>1200
<212>DNA
<213>智人
<400>250
ggucgttatg aagaggaaga agtautgtgt uatutattgt uutggggauu tgtuaauagg 60
aauaatagat agauatuauu aggggtgtat ttutgttuaa uauaaggaaa agtttutaat 120
tggagutgtu uaguatgaaa tggautaagu agtguatttt utttutucga tuutgautuu 180
autgtgacgg guautguaga utagagagat tgtgtuutag tatgaattta ggttggataa 240
atgatautta gggataaaga gaggaaagga atatuagaat utuuaagaag utgatauatt 300
ttgaaaaaat atataaaatg uuauauttua ggttttuttg tgtttaattt gaaacgtuua 360
gtaauattaa agaauaguat ttgatttgut taaauaaagt agtaauagut gaagttuutt 420
uuaaatuaut tttutgattu tutaagaggu ttguutatgu uttguagatu taguttuauu 480
tauaagauat attutgtaag gatuuaggtt uaguaaggtg tuagaatgtu utaagggttt 540
utgtuucggc gututguutg tuucguttgt guauaatgut tttguutatu uutgtttutg 600
uatagatttt agtuttuuua uuagggacgu aautgtuagt ttuutucgtu tututcggtt 660
utattuuaat utgutuatut uuuutuucgt uuucgutttu uuuaaggauu tautgagatt 720
tcgatuuuau aauttagtgg gtuuuatutu auuuagguuu cguaatuutc guuttutaut 780
tgtuagcgtt gtautauaut utgaguaggu auuuutgtgu tautuacgga agcgggauua 840
ttaggtcggu uattuutuut uauuuuacga uacguauuua utgggtcggg ucguutuutt 900
guagggagtu tuaaggatgg gutggcgtua gggagggguu uagggggcgu tttuuuaaua 960
utggtcguag tuattgttgg tataacggut agagacguuu agtgagttag uatggagggu 1020
agtgggaucg gaaaaagacg tggaaaagut gcgaaaacga guuttcgaat uatggacgcg 1080
cggguuuagu tuutuutucg agttuutuat ucggggucgt uautuauatu cgggguuutu 1140
autuauatuc gggauuutua tucggggutu tuauuuauat ucgggauuut uatguutggg 1200
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