专利汇可以提供包含脑膜炎奈瑟球菌血清群B和C抗原和其它抗原的组合物专利检索,专利查询,专利分析的服务。并且国际 专利 申请 WO99/61053公开了包含偶联于载体的脑膜炎奈瑟球菌血清群C寡糖和脑膜炎奈瑟球菌血清群B外膜蛋白的免疫原性组合物。本申请公开了还可与其它奈瑟球菌蛋白和/或针对其它致病 生物 (如流感嗜血菌、DTP、HBV等)的保护性 抗原 进行组合。,下面是包含脑膜炎奈瑟球菌血清群B和C抗原和其它抗原的组合物专利的具体信息内容。
1.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在于, 所述的组合物还包含(c)WO99/57289中公开的蛋白质或其免疫原性片段。
2.如权利要求1所述的免疫原性组合物,其特征在于,所述的成分(c)包含一 种或多种选自以下的氨基酸序列:如WO99/57280所述的2,4,6,8,10,12,14,16,18, 20,22,24,26,28,30,32,34,36,38,40,42,44,46,48,50,52,54,56,58,60,62,64,66,68, 70,72,74,76,78,80,82,84,86,88,90,92,94,96,98,100,102,104,106,108,110,112, 114,116,118,120,122,124,126,128,130,132,134,136,138,140,142,144,146,148, 150,152,154,156,158,160,162,164,166,168,170,172,174,176,178,180,182,184, 186,188,190,192,194,196,198,200,202,204,206,208,210,212,214,216,218,220, 222,224,226,228,230,232,234,236,238,240,242,244,246,248,250,252,254,256, 258,260,262,264,266,268,270,272,274,276,278,280,282,284,286,288,290,292, 294,296,298,300,302,304,306,308,310,312,314,316,318,320,322,324,326,328, 330,332,334,336,338,340,342,344,346,348,350,352,354,356,358,360,362,364, 366,368,370,372,374,376,378,380,382,384,386,388,390,392,394,396,398,400, 402,404,406,408,410,412,414,416,418,420,422,424,426,428,430,432,434,436, 438,440,442,444,446,448,450,452,454,456,458,460,462,464,466,468,470,472, 474,476,478,480,482,484,486,488,490,492,494,496,498,500,502,504,506,508, 510,512,514,516,518,520,522,524,526,528,530,532,534,536,538,540,542,544, 546,548,550,552,554,556,558,560,562,564,566,568,570,572,574,576,578,580, 582,584,586,588,590,592,594,596,598,600,602,604,606,608,610,612,614,616, 618,620,622,624,626,628,630,632,634,636,638,640,642,644,646,648,650,652, 654,656,658,660,662,664,666,668,670,672,674,676,678,680,682,684,686,688, 690,692,694,696,698,700,702,704,706,708,710,712,714,716,718,720,722,724, 726,728,730,732,734,736,738,740,742,744,746,748,750,752,754,756,758,760, 762,764,766,768,770,772,774,776,778,780,782,784,786,788,790,792,794,796, 798,800,802,804,806,808,810,812,814,816,818,820,822,824,826,828,830,832, 834,836,838,840,842,844,846,848,850,852,854,856,858,860,862,864,866,868, 870,872,874,876,878,880,882,884,886,888,890,892,894,896,898,900,902,904, 906,908,910,912,914,916,918,920,922,924,926,928,930,932,934,936,938,940, 942,944,946,948,950,952,954,956,958,960,962,964,966,968,970,972,974,976, 978,980,982,984,986,988,990,992,994,996,998,1000,1002,1004,1006,1008,1010, 1012,1014,1016,1018,1020,1022,1024,1026,1028,1030,1032,1034,1036,1038,1040, 1042,1044,1046,1048,1050,1052,1054,1056,1058,1060,1062,1064,1066,1068,1070, 1072,1074,1076,1078,1080,1082,1084,1086,1088,1090,1092,1094,1096,1098,1100, 1102,1104,1106,1108,1110,1112,1114,1116,1118,1120,1122,1124,1126,1128,1130, 1132,1134,1136,1138,1140,1142,1144,1146,1148,1150,1152,1154,1156,1158,1160, 1162,1164,1166,1168,1170,1172,1174,1176,1178,1180,1182,1184,1186,1188,1190, 1192,1194,1196,1198,1200,1202,1204,1206,1208,1210,1212,1214,1216,1218,1220, 1222,1224,1226,1228,1230,1232,1234,1236,1238,1240,1242,1244,1246,1248,1250, 1252,1254,1256,1258,1260,1262,1264,1266,1268,1270,1272,1274,1276,1278,1280, 1282,1284,1286,1288,1290,1292,1294,1296,1298,1300,1302,1304,1306,1308,1310, 1312,1314,1316,1318,1320,1322,1324,1326,1328,1330,1332,1334,1336,1338,1340, 1342,1344,1346,1348,1350,1352,1354,1356,1358,1360,1362,1364,1366,1368,1370, 1372,1374,1376,1378,1380,1382,1384,1386,1388,1390,1392,1394,1396,1398,1400, 1402,1404,1406,1408,1410,1412,1414,1416,1418,1420,1422,1424,1426,1428,1430, 1432,1434,1436,1438,1440,1442,1444,1446,1448,1450,1452,1454,1456,1458,1460, 1462,1464,1466,1468,1470,1472,1474,1476,1478,1480,1482,1484,1486,1488,1490, 1492,1494,1496,1498,1500,1502,1504,1506,1508,1510,1512,1514,1516,1518,1520, 1522,1524,1526,1528,1530,1532,1534,1536,1538,1540,1542,1544,1546,1548,1550, 1552,1554,1556,1558,1560,1562,1564,1566,1568,1570,1572,1574,1576,1578,1580, 1582,1584,1586,1588,1590,1592,1594,1596,1598,1600,1602,1604,1606,1608,1610, 1612,1614,1616,1618,1620,1622,1624,1626,1628,1630,1632,1634,1636,1638,1640, 1642,1644,1646,1648,1650,1652,1654,1656,1658,1660,1662,1664,1666,1668,1670, 1672,1674,1676,1678,1680,1682,1684,1686,1688,1690,1692,1694,1696,1698,1700, 1702,1704,1706,1708,1710,1712,1714,1716,1718,1720,1722,1724,1726,1728,1730, 1732,1734,1736,1738,1740,1742,1744,1746,1748,1750,1752,1754,1756,1758,1760, 1762,1764,1766,1768,1770,1772,1774,1776,1778,1780,1782,1784,1786,1788,1790, 1792,1794,1796,1798,1800,1802,1804,1806,1808,1810,1812,1814,1816,1818,1820, 1822,1824,1826,1828,1830,1832,1834,1836,1838,1840,1842,1844,1846,1848,1850, 1852,1854,1856,1858,1860,1862,1864,1866,1868,1870,1872,1874,1876,1878,1880, 1882,1884,1886,1888,1890,1892,1894,1896,1898,1900,1902,1904,1906,1908,1910, 1912,1914,1916,1918,1920,1922,1924,1926,1928,1930,1932,1934,1936,1938,1940, 1942,1944,1946,1948,1950,1952,1954,1956,1958,1960,1962,1964,1966,1968,1970, 1972,1974,1976,1978,1980,1982,1984,1986,1988,1990,1992,1994,1996,1998,2000, 2002,2004,2006,2008,2010,2012,2014,2016,2018,2020,2022,2024,2026,2028,2030, 2032,2034,2036,2038,2040,2042,2044,2046,2048,2050,2052,2054,2056,2058,2060, 2062,2064,2066,2068,2070,2072,2074,2076,2078,2080,2082,2084,2086,2088,2090, 2092,2094,2096,2098,2100,2102,2104,2106,2108,2110,2112,2114,2116,2118,2120, 2122,2124,2126,2128,2130,2132,2134,2136,2138,2140,2142,2144,2146,2148,2150, 2152,2154,2156,2158,2160,2162,2164,2166,2168,2170,2172,2174,2176,2178,2180, 2182,2184,2186,2188,2190,2192,2194,2196,2198,2200,2202,2204,2206,2208,2210, 2212,2214,2216,2218,2220,2222,2224,2226,2228,2230,2232,2234,2236,2238,2240, 2242,2244,2246,2248,2250,2252,2254,2256,2258,2260,2262,2264,2266,2268,2270, 2272,2274,2276,2278,2280,2282,2284,2286,2288,2290,2292,2294,2296,2298,2300, 2302,2304,2306,2308,2310,2312,2314,2316,2318,2320,2322,2324,2326,2328,2330, 2332,2334,2336,2338,2340,2342,2344,2346,2348,2350,2352,2354,2356,2358,2360, 2362,2364,2366,2368,2370,2372,2374,2376,2378,2380,2382,2384,2386,2388,2390, 2392,2394,2396,2398,2400,2402,2404,2406,2408,2410,2412,2414,2416,2418,2420, 2422,2424,2426,2428,2430,2432,2434,2436,2438,2440,2442,2444,2446,2448,2450, 2452,2454,2456,2458,2460,2462,2464,2466,2468,2470,2472,2474,2476,2478,2480, 2482,2484,2486,2488,2490,2492,2494,2496,2498,2500,2502,2504,2506,2508,2510, 2512,2514,2516,2518,2520,2522,2524,2526,2528,2530,2532,2534,2536,2538,2540, 2542,2544,2546,2548,2550,2552,2554,2556,2558,2560,2562,2564,2566,2568,2570, 2572,2574,2576,2578,2580,2582,2584,2586,2588,2590,2592,2594,2596,2598,2600, 2602,2604,2606,2608,2610,2612,2614,2616,2618,2620,2622,2624,2626,2628,2630, 2632,2634,2636,2638,2640,2642,2644,2646,2648,2650,2652,2654,2656,2658,2660, 2662,2664,2666,2668,2670,2672,2674,2676,2678,2680,2682,2684,2686,2688,2690, 2692,2694,2696,2698,2700,2702,2704,2706,2708,2710,2712,2714,2716,2718,2720, 2722,2724,2726,2728,2730,2732,2734,2736,2738,2740,2742,2744,2746,2748,2750, 2752,2754,2756,2758,2760,2762,2764,2766,2768,2770,2772,2774,2776,2778,2780, 2782,2784,2786,2788,2790,2792,2794,2796,2798,2800,2802,2804,2806,2808,2810, 2812,2814,2816,2818,2820,2822,2824,2826,2828,2830,2832,2834,2836,2838,2840, 2842,2844,2846,2848,2850,2852,2854,2856,2858,2860,2862,2864,2866,2868,2870, 2872,2874,2876,2878,2880,2882,2884,2886,2888,2890,2892,2894,2896,2898,2900, 2902,2904,2906,2908,2910,2912,2914,2916,2918,2920,2922,2924,2926,2928,2930, 2932,2934,2936,2938,2940,2942,2944,2946,2948,2950,2952,2954,2956,2958,2960, 2962,2964,2966,2968,2970,2972,2974,2976,2978,2980,2982,2984,2986,2988,2990, 2992,2994,2996,2998,3000,3002,3004,3006,3008,3010,3012,3014,3016,3018和 3020。
3.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在于, 所述的组合物还包含(c)WO99/36544中公开的蛋白质或其免疫原性片段。
4.如权利要求3所述的免疫原性组合物,其特征在于,所述的成分(c)包含一 种或多种选自以下的氨基酸序列:如WO99/36544所述的SEQ ID 2,4,6,8,10,12,14, 16,18,20,22,24,26,28,30,32,34,36,38,40,42,44,46,48,50,52,54,56,58,60,62,64, 66,68,70,72,74,76,78,80,82,84,86,88,和90。
5.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在于, 所述的组合物还包含(c)WO99/24578中公开的蛋白质或其免疫原性片段。
6.如权利要求5所述的免疫原性组合物,其特征在于,所述的成分(c)包含一 种或多种选自以下的氨基酸序列:如WO99/24578所述的SEQ ID 2,4,6,8,10,12,14, 16,18,20,22,24,26,28,30,32,34,36,38,40,42,44,46,48,50,52,54,56,58,60,62,64, 66,68,70,72,74,76,78,80,82,84,86,88,90,92,94,96,98,100,102,104,106,108,110, 112,114,116,118,120,122,124,126,128,130,132,134,136,138,140,142,144,146, 148,150,152,154,156,158,160,162,164,166,168,170,172,174,176,178,180,182, 184,186,188,190,192,194,196,198,200,202,204,206,208,210,212,214,216,218, 220,222,224,226,228,230,232,234,236,238,240,242,244,246,248,250,252,254, 256,258,260,262,264,266,268,270,272,274,276,278,280,282,284,286,288,290, 292,294,296,298,300,302,304,306,308,310,312,314,316,318,320,322,324,326, 328,330,332,334,336,338,340,342,344,346,348,350,352,354,356,358,360,362, 364,366,368,370,372,374,376,378,380,382,384,386,388,390,392,394,396,398, 400,402,404,406,408,410,412,414,416,418,420,422,424,426,428,430,432,434, 436,438,440,442,444,446,448,450,452,454,456,458,460,462,464,466,468,470, 472,474,476,478,480,482,484,486,488,490,492,494,496,498,500,502,504,506, 508,510,512,514,516,518,520,522,524,526,528,530,532,534,536,538,540,542, 544,546,548,550,552,554,556,558,560,562,564,566,568,570,572,574,576,578, 580,582,584,586,588,590,592,594,596,598,600,602,604,606,608,610,612,614, 616,618,620,622,624,626,628,630,632,634,636,638,640,642,644,646,648,650, 652,654,656,658,660,662,664,666,668,670,672,674,676,678,680,682,684,686, 688,690,692,694,696,698,700,702,704,706,708,710,712,714,716,718,720,722, 724,726,728,730,732,734,736,738,740,742,744,746,748,750,752,754,756,758, 760,762,764,766,768,770,772,774,776,778,780,782,784,786,788,790,792,794, 796,798,800,802,804,806,808,810,812,814,816,818,820,822,824,826,828,830, 832,834,836,838,840,842,844,846,848,850,852,854,856,858,860,862,864,866, 868,870,872,874,876,878,880,882,884,886,888,890,和892。
7.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在于, 所述的组合物还包含(c)WO97/28273中公开的蛋白质或其免疫原性片段。
8.如权利要求7所述的免疫原性组合物,其特征在于,所述的成分(c)包 含WO97/28273的图4或图1 3所公开的蛋白质。
9.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在于, 所述的组合物还包含(c)WO96/29412中公开的蛋白质或其免疫原性片段。
10.如权利要求9所述的免疫原性组合物,其特征在于,所述的成分(c) 包含选自WO96/29412中公开的SEQ ID 1-8的氨基酸序列。
11.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在 于,所述的组合物还包含(c)WO95/03413中公开的蛋白质或其免疫原性片段。
12.如权利要求11所述的免疫原性组合物,其特征在于,所述的成分(c) 包含选自WO95/03413中公开的SEQ ID 1-23的氨基酸序列。
13.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在 于,所述的组合物还包含(c)WO99/31132中公开的蛋白质或其免疫原性片段。
14.如权利要求13所述的免疫原性组合物,其特征在于,所述的成分(c) 包含WO99/31132中公开的SEQ ID 2的氨基酸序列。
15.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在 于,所述的组合物还包含(c)抗脑膜炎奈瑟球菌血清群A的保护性抗原。
16.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在 于,所述的组合物还包含(c)抗脑膜炎奈瑟球菌血清群W的保护性抗原。
17.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在 于,所述的组合物还包含(c)抗脑膜炎奈瑟球菌血清群Y的保护性抗原。
18.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在 于,所述的组合物还包含(c)抗流感嗜血菌的保护性抗原。
19.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在 于,所述的组合物还包含(c)抗肺炎球菌的保护性抗原。
20.如权利要求15、16、17、18或19所述的免疫原性组合物,其特征在 于,所述的成分(c)是多糖抗原。
21.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在 于,所述的组合物还包含(c)抗白喉的保护性抗原。
22.如权利要求21所述的免疫原性组合物,其特征在于,所述的成分(c) 是白喉类毒素。
23.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在 于,所述的组合物还包含(c)抗破伤风的保护性抗原。
24.如权利要求23所述的免疫原性组合物,其特征在于,所述的成分(c)是破 伤风毒素。
25.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在 于,所述的组合物还包含(c)抗百日咳的保护性抗原。
26.如权利要求25所述的免疫原性组合物,其特征在于,所述的成分(c)包含 百日咳全毒素(PT)和丝状凝血素(FHA),还可任选地含有百日咳杆菌粘附素和/ 或凝集原2和3。
27.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在 于,所述的组合物还包含(c)抗乙型肝炎病毒的保护性抗原。
28.如权利要求27所述的免疫原性组合物,其特征在于,所述的成分(c) 是HBV表面抗原和/或HBV核心抗原。
29.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在 于,所述的组合物还包含(c)抗幽门螺旋杆菌的保护性抗原。
30.如权利要求29所述的免疫原性组合物,其特征在于,所述的成分(c) 是CagA、VacA、NAP、HopX、HopY和/或尿激酶。
31.一种包含(a)NmC寡糖和(b)NmB外膜蛋白的免疫原性组合物,其特征在 于,所述的组合物还包含(c)抗脑膜炎奈瑟球菌血清群A的保护性抗原、抗脑膜炎 奈瑟球菌血清群W的保护性抗原、抗脑膜炎奈瑟球菌血清群Y的保护性抗原、抗 流感嗜血菌的保护性抗原、抗肺炎球菌的保护性抗原、抗白喉的保护性抗原、 抗破伤风的保护性抗原、抗百日咳的保护性抗原、抗乙型肝炎病毒的保护性抗 原、和/或抗幽门螺旋杆菌的保护性抗原。
32.如以上任一权利要求所述的免疫原性组合物,其特征在于,所述的NmB 外膜蛋白宜以蛋白脂质体小泡存在。
33.一种包含(a)NmC寡糖和(b)NmB蛋白919、287和/或ORF1的免疫原性 组合物。
34.如以上任一权利要求所述的免疫原性组合物,其特征在于,所述的NmC 寡糖偶联于载体。
35.如权利要求34所述的免疫原性组合物,其特征在于,所述的载体是 蛋白质。
36.如权利要求35所述的免疫原性组合物,其特征在于,所述的载体是 CRM197。
37.如以上任一权利要求所述的免疫原性组合物,其特征在于,所述的组 合物还包含选自氢氧化铝或MF59的载体。
38.一种包含以上任一权利要求所述的免疫原性组合物的疫苗。
本发明涉及免疫原性组合物,尤其是那些包含脑膜炎奈瑟球菌(Neisseria meningitidis)血清群B和C(NmB和NmC)的免疫原性分子的组合的组合物。
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