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RIBONUCLEIC ACID (RNA) INTERACTIONS

阅读:79发布:2024-02-24

专利汇可以提供RIBONUCLEIC ACID (RNA) INTERACTIONS专利检索,专利查询,专利分析的服务。并且The invention relates to a method for analysing ribonucleic acid (RNA) interactions comprising : a) cross-linking base- paired nucleotides of at least one RNA molecule and/or at least one pair of RNA molecules using a tagged, reversible cross-linking agent (preferably tagged-psoralen) under ultraviolet irradiation; b) fragmenting the said cross-linked RNA molecule(s); c) using said tag to extract said cross-linked RNA fragment(s); d) ligating the said cross-linked RNA fragment(s) to produce cross-linked ligated RNA chimera(s); e) reversing the cross-linking of the said agent to the said RNA molecule(s); f) preparing a sequence library by sequencing the ligated RNA chimera molecule(s) or pair(s); and g) analysing the sequence library to determine RNA interactions. Also disclosed is a method of studying a subject by analysing RNA interactions and attributing them to a clinical picture, or a drug discovery method by attributing an efficacy score to the drug based upon determined RNA interactions.,下面是RIBONUCLEIC ACID (RNA) INTERACTIONS专利的具体信息内容。

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