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ESTIMATION OF SIGNAL THRESHOLDS FOR MICROARRAY DATA USING MIXTURE MODELING

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专利汇可以提供ESTIMATION OF SIGNAL THRESHOLDS FOR MICROARRAY DATA USING MIXTURE MODELING专利检索,专利查询,专利分析的服务。并且The application relates to a method of classifying DNA microarray intensity data into two classes of reliable and unreliable data, comprising the steps of extracting median and mean intensities of two fluorescent signals of different wavelengths from cDNA sequences arranged in a microarray as λ 1 -channel and λ 2λ -channel raw data; estimating normal mixture model parameters corresponding to class conditional densities and prior probabilities using expectation maximization algorithm; determining in univariate analysis an optimal signal threshold for each channel or in bivariate analysis a threshold surface for said microarray raw data using Bayesian classification theory; denoting a signal intensity value as reliable, if either of the channels is larger than its respective threshold in univariate analysis or if the 2-dimentional data point falls outside of a hyper-quadratic decision region in bivariate analysis.,下面是ESTIMATION OF SIGNAL THRESHOLDS FOR MICROARRAY DATA USING MIXTURE MODELING专利的具体信息内容。

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