Effervescent potassium chloride tablet专利检索-柠檬酸钾钾盐酸，碱，盐，酸酐和碱专利检索查询-专利查询网

Effervescent potassium chloride tablet

阅读：484发布：2022-02-11

专利汇可以提供Effervescent potassium chloride tablet专利检索，专利查询，专利分析的服务。并且An effervescent potassium chloride tablet for potassium replacement therapy comprises potassium bicarbonate or carbonate, an amino acid hydrochloride and potassium citrate, fumarate, phosphate or acetate in such proportions as to form a solution having an ionic composition equivalent to potassium chloride and a weak acid such as citric, fumaric or phosphoric acid. The amino nitrogen of the amino acid hydrochloride may be primary, secondary, tertiary or quaternary. The citric or other acid imparts a long-lasting, tangy flavor to the solution, which in conjunction with a citrus or other fruit flavoring tends to mask the salty taste of the potassium chloride. The tablet further includes between about 0.5 and 3 percent leucine as a tableting lubricant, polyethylene glycol and polyvinyl pyrrolidone as binders, and silica gel as excipient as well as coloring and sweeting agents, so that a palatable and appetizing-looking, sparkling clear effervescent solution is produced.，下面是Effervescent potassium chloride tablet专利的具体信息内容。

权利要求

1. A TABLET FOR PRODUCING AN EFFERVESCENT SOLUTION TO BE ADMINISTERED AS POTASSIUM REPLACEMENT THERAPY WHICH CONSISTS ESSENTIALLY OF I. X EQUIVALENTS OF POTASSIUM BICARBONATE. II. Y EQUIVALENTS OF A POTASSIUM SALT OF CITRIC, FUMAEIC, TARTARIC, PHOSPHORIC OR ACETIC ACID, III. X + Y EQUIVALENTS OF A PHARMACEUTICALLY ACCEPTABLE HYDROCHLORIDE OF AN AMINO ACID SELECTED FROM THE GROUP CONSISTING OF THE HYDROCHLORIDE OF GLYCINE THE HYDROCHLORIDE OF SARCOSINE, THE HYDROCHLORIDE OF N,N-DI-METHYLGLYCINE, THE HYDROCHLORIDE OF ALANINE, THE HYDROCHLORIDE OF BETAINE AND THE HYDROCHLORIDE OF N-METHYLALANINE, IV. Z EQUIVALENTS OF POTASSIUM CHLORIDE, V. BINDER IN AN AMOUNT BETWEEN ABOUT 1 AND 15 PERCENT OF THE TOTAL WEIGHT, AND VI. LEUCINE AS A TABLETING LUBRICANT IN AN AMOUNT BETWEEN ABOUT 0.5 AND 3 PERCENT OF THE TOTAL WEIGHT, WHERIN THE RATIO OF X TO Y IS BETWEEN ABOUT 2:1 AND 15:1, THE RATIO OF X TO Z IS BETWEEN ABOUT 1:2 AND 2:1 AND THE SUM OF X +Y+Z PROVIDES BETWEEN ABOUT 5 AND 50 MILLIEQUILAVENTS OF POTASSIUM CHLORIDE.

2. A tablet as claimed in claim 1, wherein the binder is a mixture of polyvinyl pyrrolidone and polyethylene glycol.

3. A tablet as claimed in claim 2 wherein the polyvinyl pyrrolidone and polyethylene glycol are present in a ratio of between about 2:1 and about 1:1.

4. A tablet as claimed in claim 1 comprising up to 1 percent of finely powdered silica gel.

5. A tablet as claimed in claim 1, further comprising a food grade coloring and fruit flavoring.

6. A tablet as claimed in claim 5, wherein the flavoring is natural or synthetic orange, lemon, lime, or grapefruit and the coloring is substantially the color of the citrus fruit of the flavoring.

7. A tablet for producing an effervescent solution to be administered as potassium replacement therapy which consists essentially of i. w equivalents of potassium carbonate, ii. y equivalents of a potassium salt of citric, fumaric, tartaric, phosphoric or acetic acid, iii. w + y equivalents of a pharmaceutically acceptable hydrochloride of an amino acid selected from the group consisting of the hydrochloride of glycine, the hydrochloride of sarcosine, the hydrochloride of N,N-di-methylglycine, the hydrochloride of alanine, the hydrochloride of betaine and the hydrochloride of N-methylalanine, iv. z equivalents of potassium chloride, v. binder in an amount between about 1 and 15 percent of the total weight, and vi. leucine as a tableting lubricant in an amount between about 0.5 and 3 percent of the total weight, wherein the ratio of w to y is between about 4:1 and 30:1, the ratio of w to z is between about 1:1 and 4:1 and the sum of w + y + z provides between about 5 and 50 milliequivalents of potassium chloride.

8. A tablet as claimed in claim 7 wherein the binder is a mixture of polyvinyl pyrrolidone and polyethylene glycol.

9. A tablet as claimed in claim 7 comprising up to 1 percent of finely powdered silica gel.

说明书全文

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