Intramuscular vaccination program and vaccine against rhinopneumonitis and process for preparing it专利检索-反刍动物家畜畜牧业专利检索查询-专利查询网

Intramuscular vaccination program and vaccine against rhinopneumonitis and process for preparing it

阅读：974发布：2022-01-13

专利汇可以提供Intramuscular vaccination program and vaccine against rhinopneumonitis and process for preparing it专利检索，专利查询，专利分析的服务。并且Method of preparing a vaccine effective against equine rhinopneumonitis which comprises attenuating rhinopneumonitis virus, after initial cultivation, by continuous passage through primary cell cultures of tissues not originating in equidae, e.g. piglet kidney cell cultures, until it has lost pathogenicity for the horse. A parenterally administrable vaccine prepared in this manner. A method for immunizing horses and an intramuscular vaccination program against equine rhinopneumonitis in horses.，下面是Intramuscular vaccination program and vaccine against rhinopneumonitis and process for preparing it专利的具体信息内容。

权利要求

2. The method of preparing a vaccine for the intramuscular vaccination of horses against equine rhinopneumonitis (abortion of mares) which comprises: cultivating and multiplying rhinopneumonitis viruses in susceptible tissues selected from susceptible organs, susceptible test animals, and susceptible permanent cell lines suitable for the cultivation and multiplication of said viruses, said multiplying involving from three to ten passages; completely attenuating the viruses until they have lost pathogenicity for the horse by passing the viruses, in at least 20 continuous passages, through primary cell cultures selected from kidneys of sheep, pigs, and piglets and from stable permanent cell lines derived from said primary cell cultures; and harvesting the virus-containing material; said harvested material meeting the following criteria for complete attenuation: a. the infectuosity titer for golden hamsters after intraperitoneal infection must be reduced by 3 powers of 10 with respect to the starting value; b. over 70 percent of golden hamsters, inoculated with the attenuated virus (0.5 ml parenterally) and 3 weeks later infected intraperitoneally with the virulent starting virus (10,000 LD50/ml), must survive the challenge infection; C. highly pregnant mares between the 7th and 9th month of pregnancy, which are susceptible to the viral abortion virus, must not become diseased and abort after intramuscular or subcutaneous injection of the attenuated virus (5 ml, virus titer between 106.5 and 107.5CID50/ml) and local vaccination reactions must not occur (after the first vaccination, a short-time biphasal fever attack between the 18th and the 48th hour and between the 8th and the 9th day is unobjectionable; after the second vaccination, however, no fever reaction must occur); and d. foals at the age of 2 - 3 months which do not have specific antibodies against rhinopneumonitis virus must not become diseased after parenteral injection with the attenuated virus.

3. A vaccine for the intramuscular vaccination of horses against equine rhinopheumonitis (abortion of mares) prepared by the method of claim 2.

4. The method of protecting horses against equine rhinopneumonitis (abortion of mares) which comprises intramuscularly vaccinating said horses with a vaccine prepared by the method of claim 2.

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Intramuscular vaccination program and vaccine against rhinopneumonitis and process for preparing it

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