| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 一种颅内磁共振血管壁成像质量的评价方法 | CN202310025424.2 | 2023-01-09 | CN116188398A | 2023-05-30 | 彭雯佳; 张雪凤; 赵海燕; 王烁; 陈录广; 李帅; 李凘纯; 王振; 陈玉坤; 陆建平; 邵成伟 |
| 本发明公开了一种颅内磁共振血管壁成像质量的评价方法，包括主观质量评价量表和客观质量评价；所述主观质量评价量表评价的内容包括血管壁、血流抑制和运动伪影三方面；所述客观质量评价通过计算信噪比、对比度、对比噪声比这三个指标来实现。为了对颅内动脉管壁的磁共振成像质量作出综合评价，本发明的颅内磁共振血管壁成像质量的评价方法，通过对脑血管区域进行划分，定位不同段的血管区域，并通过主观评价和客观质量指标计算的方法对成像质量作出综合评估。 | ||||||
| 2 | IMAGING OF ACTIVATED VASCULAR ENDOTHELIUM USING IMMUNOMAGNETIC MRI CONTRAST AGENTS | PCT/US2007023048 | 2007-11-01 | WO2008063371A3 | 2008-10-30 | DOYLE GERALD V |
| lmmunomagnetic nanoparticles are used as a contrast agent for enhancing medical diagnostic imaging such as magnetic resonance imaging (MRI). The present invention is directed to methods of making targeted MRI contrast agents from immunomagnetic particles, and to methods of using such MRI contrast agents. Typically, such targeted MRI contrast agents provide enhanced relaxivity, improved signal-to-noise, targeting ability, and resistance to agglomeration. Methods of making such MRI contrast agents typically afford better control over particle size, and methods of using such MRI contrast agents typically can afford enhanced blood clearance rates and distribution. The ability to use the contrast agents im MRI provides a tool in the diagnosis and treatment of several disease states. | ||||||
| 3 | 혈관내 혈전을 나타내기 위한 자기 공명 영상화에서의조영제로서 퍼플루오로알킬 함유 금속 착물의 용도 | KR1020057000346 | 2003-07-05 | KR1020050017095A | 2005-02-21 | 미셀위츠,번드; 플랏제크,요한스; 카와타,요코; 웨인만,한스-요하임; 요카와,타키시; 니에드발라,울리히 |
| 본 발명은 혈관내 혈전을 나타내기 위한 MR 영상화에서의 조영제로서 퍼플루오로알킬을 함유하는 금속 착물의 용도에 관한 것이다. 상기 착물은 임계 미셀 형성 농도 < 10 -3 mol/l, 유체역학적 미셀 직경 (2 Rh) > 1 nm, 및 플라스마 중의 양성자 이완도 (proton relaxivity) (R 1 ) > 10 l/mmol.s이다. | ||||||
| 4 | Method of detecting stenosis in peripheral arterial vessel through magnetic resonance imaging and its device | JP2001175357 | 2001-06-11 | JP2002095647A | 2002-04-02 | HO VINCENT B; FOO THOMAS KWOK-FAH |
| PROBLEM TO BE SOLVED: To provide a method of detecting a stenosis in peripheral arterial vessels through a magnetic resonance technology and a method of displaying severity of a stenosis, and to provide a device for them. SOLUTION: A patient's (280) peripheral arterial vessels are screened to see if there are any disorders or narrowed blood vessels (100,108), using a magnetic resonance technology (10). If a stenosis is found, the stenosis is graded according to its severity (142). While obtaining a series of the first MR images with a low resolution (126), a contrast agent bolus which passes through the patient (280) is tracked (354). This first examination increases sensitivity of detecting disorders by using a bipolar gradient wave which senses a flow along with gradient echo imaging pulse sequence (160). After the stenosis (108) is detected, the stenosis is graded (142) by using the second MR image with a higher resolution (140) than the first MR image. | ||||||
| 5 | MRI ENHANCING INTRAVASCULAR DEVICE WITH TRIMMABLE CAPACITOR | EP03784809.0 | 2003-07-24 | EP1537429A1 | 2005-06-08 | WEBER, Jan |
| The present invention is directed to an MIR enhancing intravascular device (200) deployable in a body. In one embodiment, the MRI enhancing device (200) is formed of a wire loop (218) and a capacitor that is at least partially formed by the wire used in forming the wire loop (218) . The device (200) may comprise a dielectric material (410) displaceably movable between the plates of the capacitor when the wire is in the body to vary the capacitance of the capacitor. | ||||||
| 6 | MRI ENHANCING INTRAVASCULAR FILTER DEVICE | EP03784809.0 | 2003-07-24 | EP1537429B1 | 2011-03-09 | WEBER, Jan |
| The present invention is directed to an MIR enhancing intravascular device (200) deployable in a body. In one embodiment, the MRI enhancing device (200) is formed of a wire loop (218) and a capacitor that is at least partially formed by the wire used in forming the wire loop (218) . The device (200) may comprise a dielectric material (410) displaceably movable between the plates of the capacitor when the wire is in the body to vary the capacitance of the capacitor. | ||||||
| 7 | VERWENDUNG VON PERFLUORALKYLHALTIGEN METALLKOMPLEXEN ALS KONTRASTMITTEL IM MR-IMAGING ZUR DARSTELLUNG VON INTRAVASALEN THROMBEN | PCT/EP2003/006836 | 2003-06-26 | WO2004006979A2 | 2004-01-22 | MISSELWITZ, Bernd; PLATZEK, Johannes; KAWATA, Yoko; WEINMANN, Hanns-Joachim; YOKAWA, Takishi; NIEDBALLA, Ulrich |
Die Erfindung betrifft die Verwendung von perfluoral-kylhaltigen Metallkomplexen, die eine kritische Mizellbil-dungskonzentration < 10-3 mol/l, einen hydrodynamischen Mizelldurchmesser (2 Rh) > 1 nm und eine Protonen-Relaxivity im Plasma (R1) > 10 l/mmol×s aufweisen, als Kontrastmittel im MR-Imaging zur Dar-stellung von intravasalen Thromben. |
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| 8 | VERWENDUNG VON PERFLUORALKYLHALTIGEN METALLKOMPLEXEN ALS KONTRASTMITTEL IM MR-IMAGING ZUR DARSTELLUNG VON INTRAVASALEN THROMBEN | PCT/EP2003/007274 | 2003-07-05 | WO2004006965A2 | 2004-01-22 | MISSELWITZ, Bernd; PLATZEK, Johannes; KAWATA, Yoko; WEINMANN, Hanns-Joachim; YOKAWA, Takishi; NIEDBALLA, Ulrich |
Die Erfindung betrifft die Verwendung von perfluoralkylhaltigen Metallkomplexen, die eine kritische Mizellbildungskonzentration < 10-3 mol/l, einen hydrodynamischen Mizelldurchmesser (2 Rh) > 1 nm und eine Protonen-Relaxivity im Plasma (R1) > 10 l/mmol.s aufweisen, als Kontrastmittel im MR-Imaging zur Darstellung von intravasalen Thromben. |
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| 9 | SYSTEM AND METHOD FOR MAGNETIC RESONANCE IMAGING OF INTRACRANIAL VESSEL WALLS | US13922111 | 2013-06-19 | US20130335083A1 | 2013-12-19 | Bruce A. Wasserman; Ye Qiao |
| A magnetic resonance imaging (MRI) system for intracranial vessel wall imaging. The MRI system includes a radio frequency (RF) coil system to irradiate radio frequency (RF) pulses into a region of interest and detect a plurality of RF response signals, and a signal processing unit adapted to analyze the plurality of RF response signals. The RF coil system arranges the RF pulses in a pulse sequence including an excitation pulse and refocusing pulses which induce corresponding flip angles. A minimum flip angle is in the range of 30 degrees to 65 degrees, and a maximum flip angle is in the range of 100 degrees to 150 degrees. The signal processing unit analyzes the RF response signals with a three-dimensional isotropic resolution of 500 cubic microns or less and orders the RF response signals in k-space to enhance contrast between intracranial vessel wall tissue and cerebrospinal fluid or blood. | ||||||
| 10 | METHOD FOR TRANSCATHETER INTRA-ARTERIAL PERFUSION MAGNETIC RESONANCE IMAGING | US12262651 | 2008-10-31 | US20090116711A1 | 2009-05-07 | Andrew Christian Larson; Reed Ali Omary; Dingxin Wang |
| A method to serially determine changes in perfusion to tissues is provided. This method involves injecting contrast material into a catheter that is positioned in the blood supply proximal to the targeted tissue of interest, acquiring a time series of images that depicts the uptake of this contrast material within the tissue, deriving semi-quantitative or quantitative perfusion metrics based upon the time series of perfusion images, altering perfusion to the targeted tissue by means of injecting pharmacologic agents or embolic agents into the blood vessels supplying the targeted tissue, repeating the acquisition of perfusion images to serially monitor changes in tissue perfusion after each alteration, and calculating changes in perfusion metrics after each series of perfusion images. This method is used to monitor changes in perfusion to various tissues, including a diverse array of tumors. The perfusion imaging method can be acquired using magnetic resonance, x-ray computed tomography, or radionuclide imaging. The perfusion metric is serially measured during an embolization procedure as a means of measuring changes in tissue perfusion or to target an endpoint based upon a specific alteration in the calculated perfusion metric. | ||||||
| 11 | In vivo magnetic resonance vascular imaging using laser-polarized gas microbubbles | US288212 | 1999-04-08 | US6051208A | 2000-04-18 | G. Allan Johnson; Mark S. Chawla |
| Nuclear magnetic resonance (NMR) images of a human or animal subject's vascular system are enhanced by injecting a liquid comprised of a biocompatible liquid carrier and a dispersion of hyperpolarized gas microbubbles into the subject, followed by generating an image by NMR representing a spatial distribution of the hyperpolarized gas microbubbles injected into the human or animal subject's vascular system. Preferably, the hyperpolarized gas is Helium-3 and/or Xenon-129. The microbubbles most preferably have a mean diameter of less than about 35 .mu.m. | ||||||
| 12 | INTRAVASCULAR CATHETER SYSTEM WITH CONVERTIBLE SHEATH EXTENSION FOR MAGNETIC RESONANCE IMAGING AND METHOD | EP98966956.9 | 1998-09-23 | EP1019119A1 | 2000-07-19 | HURTAK, Wenzel, Franz; MOUS, Frans; NAP, Cornelis, Philipus |
| This invention relates to an intravascular catheter system that includes a catheter introduction sheath (1), as well as a convertible sheath extension (3) for use during magnetic resonance procedures. The catheter introduction sheath (1) includes a tubular basic body (4) with a hemostatic valve (13) at its proximal end, is adapted to allow the selective insertion or various intravascular devices, such as catheters and guidewires. The catheter sheath introducer (1) is inserted percutaneously within the vascular system of a patient. The hemostatic valve (13) resists leaking of blood, while automatically opening and closing to allow vascular devices of differing types to be inserted and removed. In addition, the convertible sheath extension (3) has an elongated tubular body (2) with a proximal flange or handle (11), and also has a selectively detachable coupling (14) adapted to cooperate with the valve housing (5) of the catheter sheath introducer (11). | ||||||
| 13 | INTRAVASCULAR CATHETER SYSTEM WITH CONVERTIBLE SHEATH EXTENSION FOR MAGNETIC RESONANCE IMAGING AND METHOD | EP98966956.9 | 1998-09-23 | EP1019119B1 | 2005-02-16 | HURTAK, Wenzel, Franz; MOUS, Frans; NAP, Cornelis, Philipus |
| This invention relates to an intravascular catheter system that includes a catheter introduction sheath (1), as well as a convertible sheath extension (3) for use during magnetic resonance procedures. The catheter introduction sheath (1) includes a tubular basic body (4) with a hemostatic valve (13) at its proximal end, is adapted to allow the selective insertion or various intravascular devices, such as catheters and guidewires. The catheter sheath introducer (1) is inserted percutaneously within the vascular system of a patient. The hemostatic valve (13) resists leaking of blood, while automatically opening and closing to allow vascular devices of differing types to be inserted and removed. In addition, the convertible sheath extension (3) has an elongated tubular body (2) with a proximal flange or handle (11), and also has a selectively detachable coupling (14) adapted to cooperate with the valve housing (5) of the catheter sheath introducer (11). | ||||||
| 14 | INTRAVASCULAR CATHETER SYSTEM WITH CONVERTIBLE SHEATH EXTENSION FOR MAGNETIC RESONANCE IMAGING AND METHOD | EP98966956 | 1998-09-23 | EP1019119A4 | 2002-02-06 | HURTAK WENZEL FRANZ; MOUS FRANS; NAP CORNELIS PHILIPUS |
| This invention relates to an intravascular catheter system that includes a catheter introduction sheath (1), as well as a convertible sheath extension (3) for use during magnetic resonance procedures. The catheter introduction sheath (1) includes a tubular basic body (4) with a hemostatic valve (13) at its proximal end, is adapted to allow the selective insertion or various intravascular devices, such as catheters and guidewires. The catheter sheath introducer (1) is inserted percutaneously within the vascular system of a patient. The hemostatic valve (13) resists leaking of blood, while automatically opening and closing to allow vascular devices of differing types to be inserted and removed. In addition, the convertible sheath extension (3) has an elongated tubular body (2) with a proximal flange or handle (11), and also has a selectively detachable coupling (14) adapted to cooperate with the valve housing (5) of the catheter sheath introducer (11). | ||||||
| 15 | VERWENDUNG VON PERFLUORALKYLHALTIGEN METALLKOMPLEXEN ALS KONTRASTMITTEL IM MR-IMAGING ZUR DARSTELLUNG VON INTRAVASALEN THROMBEN | EP03740431.6 | 2003-07-05 | EP1519756B1 | 2007-05-02 | MISSELWITZ, Bernd; PLATZEK, Johannes; KAWATA, Yoko; WEINMANN, Hanns-Joachim; YOKAWA, Takishi; NIEDBALLA, Ulrich |
| The invention relates to the use of metal complexes containing perfluoroalkyl as contrast agents in MR imaging for representing intravascular thrombi. Said complexes have a critical micelle-formation concentration < 10-3 mol/l, a hydrodynamic micelle diameter (2 Rh) > 1 nm and a proton relaxivity in plasma (R1) > 10 l/mmol.s. | ||||||
| 16 | VERWENDUNG VON PERFLUORALKYLHALTIGEN METALLKOMPLEXEN ALS KONTRASTMITTEL IM MR-IMAGING ZUR DARSTELLUNG VON INTRAVASALEN THROMBEN | EP03740431.6 | 2003-07-05 | EP1519756A2 | 2005-04-06 | MISSELWITZ, Bernd; PLATZEK, Johannes; KAWATA, Yoko; WEINMANN, Hanns-Joachim; YOKAWA, Takishi; NIEDBALLA, Ulrich |
| The invention relates to the use of metal complexes containing perfluoroalkyl as contrast agents in MR imaging for representing intravascular thrombi. Said complexes have a critical micelle-formation concentration < 10-3 mol/l, a hydrodynamic micelle diameter (2 Rh) > 1 nm and a proton relaxivity in plasma (R1) > 10 l/mmol.s. | ||||||
| 17 | 磁共振成像方法 | CN202311457609.7 | 2020-08-19 | CN117518053A | 2024-02-06 | 赵乐乐 |
| 本申请涉及一种磁共振成像方法。上述磁共振成像方法，包括：采用TOF 3D序列对检测对象的3D容积执行顺血流采集，得到第一组磁共振信号；所述检测对象为血管；采用所述TOF 3D序列对所述检测对象的3D容积执行逆血流采集，得到第二组磁共振信号；重建所述第一组磁共振信号和所述第二组磁共振信号，获得所述检测对象的磁共振图像。上述方法中，通过两次血流信号的采集，可以有效减少血流饱和效应，使得整个3D容积的血流信号强度均一化，有利于减小血管内信号强度波动对磁共振成像的影响。 | ||||||
| 18 | 磁共振血管成像方法、装置、成像设备及存储介质 | CN202311405916.0 | 2023-10-26 | CN117452301A | 2024-01-26 | 文悦; 章星星; 蒋先旺 |
| 本发明公开了一种磁共振血管成像方法、装置、成像设备及存储介质。首先，向成像区域依次施加组合脉冲，使水信号和脂肪信号分离；在水信号和脂肪信号分离后，向成像区域施加第一损毁梯度，以饱和脂肪信号的横向分量；最后，向成像区域施加成像采集序列，以获取磁共振血管成像数据。通过在向成像区域施加激发射频脉冲之前利用组合脉冲完成对脂肪信号的抑制，使后续的TE不再兼顾压脂的作用，缩短TE，降低体素内自旋散相的影响，减少血管内信号丢失，从而达到优化血管显示的目的。因此，通过上述方式获取的磁共振血管成像数据，可以提高整体磁共振血管图像的质量。 | ||||||
| 19 | 血管模型建立方法、装置及可读取存储介质 | CN201911051033.8 | 2019-10-30 | CN110742688B | 2021-05-25 | 陈端端; 李振锋; 梅玉倩; 梁世超; 石悦 |
| 本申请提供一种血管模型建立方法、装置及可读取存储介质，涉及医学成像技术领域，该方法包括：根据检测目标的动脉血管的核磁共振扫描结果确定初始血管模型；根据检测目标的脉搏压以及核磁共振扫描结果计算初始血管模型的第一血管壁位移数据，根据核磁共振扫描结果确定动脉血管的第二血管壁位移数据；若第一血管壁位移数据与第二血管壁位移数据之间的差值在预设范围之内，则根据第一血管壁位移数据以及初始血管模型确定检测目标的血管模型。由于第二血管壁位移数据表示检测目标动脉血管的实际血管壁位移情况，根据与第二血管壁位移数据相差不大的第一血管壁位移数据以及初始血管模型能够准确的确定检测目标的血管模型。 | ||||||
| 20 | 血管模型建立方法、装置及可读取存储介质 | CN201911051033.8 | 2019-10-30 | CN110742688A | 2020-02-04 | 陈端端; 李振锋; 梅玉倩; 梁世超; 石悦 |
| 本申请提供一种血管模型建立方法、装置及可读取存储介质，涉及医学成像技术领域，该方法包括：根据检测目标的动脉血管的核磁共振扫描结果确定初始血管模型；根据检测目标的脉搏压以及核磁共振扫描结果计算初始血管模型的第一血管壁位移数据，根据核磁共振扫描结果确定动脉血管的第二血管壁位移数据；若第一血管壁位移数据与第二血管壁位移数据之间的差值在预设范围之内，则根据第一血管壁位移数据以及初始血管模型确定检测目标的血管模型。由于第二血管壁位移数据表示检测目标动脉血管的实际血管壁位移情况，根据与第二血管壁位移数据相差不大的第一血管壁位移数据以及初始血管模型能够准确的确定检测目标的血管模型。 | ||||||
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