Photoactive bioadhesive compositions

申请号 US14646445 申请日 2013-11-21 公开(公告)号 US10005936B2 公开(公告)日 2018-06-26
申请人 Nanyang Technological University; 发明人 W. J. Terry Steele; Vladislav Papper; Robert S. Marks;
摘要 A novel diazirine-based biocompatible polymer that can be used as on-demand or tunable bioadhesive and applied across various clinically important surfaces. The biocompatible polymer comprises a single strand of repeating units and up to 5,000 photoreactive diazirine groups covalently attached to it. A bioadhesive composition comprises the polymer of the present invention and suitable solvents, surfactants, stabilizers, fillers and other additives. The composition may additionally contain metallic particles of size less than 50 micron made of rare earth elements and has UV or NIR transparency less than 1 optical density unit per 1 centimeter. The poly-diazirine surface grafted thin films can be used for minimally invasive surgeries.
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