4(3-Carboxy-4-hydroxyphenylazo)-benzenlsulphonamide pyridine compounds having immunosuppressive effects |
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| 申请号 | US30790372 | 申请日 | 1972-11-20 | 公开(公告)号 | US3915951A | 公开(公告)日 | 1975-10-28 |
| 申请人 | PHARMACIA AB; | 发明人 | AGBACK KARL HUBERT; LINDBLOM RAGNVALD ERIK; | ||||
| 摘要 | The compound: where A is either (1) WHERE R1; R2 and R3 are either hydrogen, lower alkyl, halogen, lower alkoxy, cyano, nitro or carboxamide and R4 is either lower alkyl, halogen, lower alkoxy, cyano, nitro or carboxamide, or (2) where R1''; R2''; R3'' and R4'' are either hydrogen, lower alkyl, halogen, lower alkoxy, cyano, nitro or carboxamido. These compounds are useful in immunosuppressives especially in skin transplants. |
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| 权利要求 | 1. A 4-(3-CARBOXY-4-HYDROXY-PHENYLAZO)-BENZENESULPHONAMIDE PYRIDINE OF THE FORMULA 2. A compound as claimed in claim 1 in the form of its pharmaceutically acceptable salt. 3. 2-(4-(3-carboxy-4-hydroxy-phenylazo)-benzene sulphonamido)-3-methyl-pyridine. 4. 2-(4-(3-carboxy-4-hydroxy-phenylazo)-benzene sulphonamido)-4-methyl-pyridine. 5. 2-(4-(3-carboxy-4-hydroxy-phenylazo)-benzene sulphonamido)-5-methyl-pyridine. 6. 2-(4-(3-carboxy-4-hydroxy-phenylazo)-benzene sulphonamido)-6-methyl-pyridine. 7. 2-(4-(3-carboxy-4-hydroxy-phenylazo)-benzene sulphonamido)-4, 6-dimethyl-pyridine. 8. 2-(4-(3-carboxy-4-hydroxy-phenylazo)-benzene sulphonamido)-5-chloro-pyridine. 9. 2-(4-(3-carboxy-4-hydroxy-phenylazo)-benzene sulphonamido)-3-ethyl-pyridine. 10. 2-(4-(3-carboxy-4-hydroxy-phenylazo)-benzene sulphonamido)-3-ethoxy-pyridine. 11. 2-(4-(3-carboxy-4-hydroxy-phenylazo)-benzene sulphonamido)-3-chloro-pyridine. 12. 3-(4-(3-carboxy-4-hydroxy-phenylazo)-benzene sulphonamido)-2,6-dimethyl-pyridine. 13. 3-(4-(3-carboxy-4-hydroxy-phenylazo)-benzene sulphonamido)-2-chloro-pyridine. 14. 5-bromo-2-(4-(3-carboxy-4-hydroxy-phenylazo)-benzenesulphonamido)-6-methyl -pyridine. 15. 3-(4-(3-carboxy-4-hydroxy-phenylazo)-benzene sulphonamido)-pyridine. 16. 3-(4-(3-carboxy-4-hydroxy-phenylazo)-benzene sulphonamido)-6-methoxy-pyridine. |
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