Triazabutadienes as cleavable cross-linkers |
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| 申请号 | US15427988 | 申请日 | 2017-02-08 | 公开(公告)号 | US10125105B2 | 公开(公告)日 | 2018-11-13 |
| 申请人 | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA; | 发明人 | John C. Jewett; Flora W. Kimani; Lindsay Guzman; Brandon M. Cornali; | ||||
| 摘要 | Triazabutadiene molecules as cleavable cross-linkers adapted to cross-link components with click chemistry, e.g., clickable triazabutadienes. For example, in some embodiments, the triazabutadienes feature alkyne handles attached to the imidazole portion or the aryl portion of the triazabutadienes, wherein the alkyne handles can link to azide handles (e.g., azide handles disposed on other components) via click chemistry. Also described are methods of producing said clickable triazabutadienes and methods of use of said clickable triazabutadienes. The present invention also features methods of cleaving said clickable triazabutadienes, e.g., for liberating the diazonium species for further chemical reactions. | ||||||
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