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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	基于烟草及其燃烧副产物中存在的高级糖基化终产物的测定和处理方法	CN96180126.3	1996-12-23	CN1211321A	1999-03-17	A·瑟拉米; R·J·布卡拉; H·维拉萨拉; H·W·富恩德斯; C·J·瑟拉米
本发明公开了用于测定高级糖基化终产物(AGEs)的蓄积、和用于降低高级糖基化终产物蓄积的方法,这些方法基于这样一种发现,即AGEs及其前体的糖化毒素(glycotoxins)存在于烟草及其副产物中。更具体地说,这些方法基于这样一种观察结果,即相对于非吸烟个体来说,吸烟或另外使用烟草的个体的AGEs水平已经增加。本方法涉及在两种个体中和烟草及其副产物(烟雾)中测定AGE水平、并涉及使用能够与糖基化产物反应的试剂治疗这样的个体以避免或减少AGEs在体内的累积。本发明还公开了用于评价烟草产物以测定其贮存情况和器官感觉能力和潜能的方法、用于处理环境空气以降低AGE水平的方法、和用于处理烟草产物和燃烧副产物以降低其中AGE水平的方法。例如,使用一种剂量器或类似装置可以吸入并评价空气或其它样品,从而测定AGE水平是否超过正常值,此后可以完成测定以改善环境条件。同样,本发明公开了用于从烟草的烟雾中去除AGEs的滤器和类似装置。本发明关注并包括所有这类方法和相应的材料。
2	清凉化合物	CN200680008798.8	2006-03-15	CN101141890A	2008-03-12	L·科尔; S·M·富勒尔; C·加洛潘; P·V·克拉韦克; J·P·斯莱克
一种通过施加式(I)化合物而向身体皮肤或黏膜提供清凉感觉的方法，其中，X为H或(CH2)n－R，n为0或1，Y和Z独立地选自H、OH、苯基、C1－C4直链或支链烷基或C1－C4直链或支链烷氧基，或者X和Y一起形成选自－O－CH2－O－、－N＝CH－O－和－N＝CH－S－的二价基团，所述二价基团和与其相连的碳原子一起形成5－元环；和R为带有未成键电子的基团，R1为H或C1－C5支链烷基，R2和R3为C1－C4支链烷基，或者R2和R3一起形成最多具有10个碳的单环、二环或三环基团，条件是R1、R2和R3一起包括至少6个碳。可以将该化合物结合到产品中，例如洁齿剂、食品、糖果、饮料，以及化妆品和药物制剂中。
3	Soft compound	JP2008502216	2006-03-15	JP2008535806A	2008-09-04	ギャロパン，クリストフ; クラウェック，パブロ，ヴィクター; コール，ルシェンヌ; スラック，ジェイ，パトリック; フラー，シュテファン，ミヒャエル
身体の皮膚または粘膜へ清涼感を与える方法であって、式Ｉ式中、Ｘは、Ｈまたは（ＣＨ _２） _ｎ −Ｒであり、ｎは、０または１であり、ＹおよびＺは、独立して、Ｈ、ＯＨ、フェニル、Ｃ _１〜Ｃ _４の直鎖もしくは分枝鎖アルキル、またはＣ _１〜Ｃ _４の直鎖もしくは分枝鎖アルコキシであり、またはＸおよびＹは、−Ｏ−ＣＨ _２ −Ｏ−、−Ｎ＝ＣＨ−Ｏ−および−Ｎ＝ＣＨ−Ｓ−からなる群より選択される２価の基を共に形成し、これらは結合する炭素原子と共に５員環を形成し；および、Ｒは、非結合電子を有する基であり、Ｒ ^１は、ＨまたはＣ _１〜Ｃ _５の分枝鎖アルキルであり、Ｒ ^２およびＲ ^３は、Ｃ _１〜Ｃ _４の分枝鎖アルキルであり、またはＲ ^２およびＲ ^３は、Ｒ ^１、Ｒ ^２およびＲ ^３が合わせて少なくとも６個の炭素原子を含む条件で、最大１０個の炭素原子を有する単環式、二環式または三環式の基を共に形成する、で表される化合物の適用による、前記方法。本化合物は、例えば、歯磨き剤、食料品、菓子類、飲料、化粧品および医薬製剤等の製品中に取り入れてもよい。
4	Measurement and therapeutic methods for on the basis of the existence of higher-order glycosylation end product of tobacco and during the combustion by-products	JP52384697	1996-12-23	JP2000507346A	2000-06-13	ヘレンヴラッサラ; クララジェイセラミ; アントニーセラミー; ヘンリーダブリューフォンズ; リチャードジェイブカラ
(57)【要約】高次糖付加最終生成物（ＡＧＥ）の蓄積の測定方法及び高次糖付加最終生成物の蓄積の低減方法が開示されており、これらはＡＧＥ及びその前駆体グリコトキシンがタバコ及びその副生成物中に存在することの発見に基づくものである。より具体的には、この方法は、タバコを吸う人、そうでなければタバコを使用する人は、非喫煙者に比べてＡＧＥのレベルが増加しているとの発見に焦点を置くものである。本発明の方法は、人、及びタバコ、その副生成物、煙の両方においてＡＧＥのレベルを測定すること、及びこのような人をグリコシル化生成物と反応して体内のＡＧＥの増加を避けるか消失させることができる薬剤で治療することに関する。その貯蔵状況及び感覚刺激に反応する能力及び潜在力を決定するタバコ製品の評価方法、周囲大気で処理してＡＧＥのレベルを低下させる方法、タバコ製品及び燃焼副生成物を処理してそのＡＧＥのレベルを低下させる方法をも開示する。例えば、計量計又はそのような装置で空気又は他の試料を採取し、評価して、ＡＧＥレベルが通常値を越えているか否かを測定でき、その後、周囲条件を修正することができる。又、タバコの煙からＡＧＥを除去するためのフィルター及び同様の機器も開示される。このような方法及び対応する材料の全てが意図され、そして含まれる。
5	Tobacco product	JP5164376	1976-05-06	JPS51139698A	1976-12-02	CHIYAARUSU DABURIYUU MIRAA; JIEEMUSU PII DEITSUKAASON; CHIYAARUSU II RITSUKUSU

6	JPS5039143B1 -	JP8830971	1971-11-08	JPS5039143B1	1975-12-15
Process for altering the flavors and/or fragrances of materials which comprise adding thereto effective amounts of at least one thiazole having the formula WHEREIN R is hydrogen, alkyl, or acyl; X is alkoxy, hydrogen, or, when R and Y are alkyl, alkyl; and Y is alkyl, acyl, alkoxy or hydrogen, no more than two of R, X, and Y being hydrogen; compositions containing such thiazoles and compositions; perfumed materials containing such thiazoles and compositions; and novel thiazoles and processes for producing same.
7	Methods for measurement predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts	US617349	1996-03-18	US5854000A	1998-12-29	Richard J. Bucala; Helen Vlassara; Anthony Cerami; Henry W. Founds
Methods are disclosed for measuring the accumulation of advanced glycosylation endproducts (AGEs), which are predicated on the discovery that such AGEs are present in tobacco and its byproducts. More particularly, the methods focus on the observation that individuals who smoke or otherwise use tobacco have increased levels of AGEs over non-smoking individuals. The present methods relate to the measurement of AGE levels in both individuals and in tobacco and its byproduct, smoke. Methods are also disclosed for the evaluation of the tobacco products to determine their storage status and organoleptic capacity and potential, as well as for the treatment of the ambient to lower AGE levels. For example, air or other samples may be taken and evaluated by a dosimeter or like device, to determine whether AGE levels exceed normal, after which measures could be implemented to remediate the ambient condition. All such methods and corresponding materials are contemplated and included.
8	Isobutyl substituted heterocyclic compounds for augmenting or enhancing the organoleptic properties of smoking tobaccos and smoking tobacco articles	US887627	1978-03-17	US4207905A	1980-06-17	Donald A. Withycombe; Braja D. Mookherjee; Manfred H. Vock; Joaquin F. Vinals
Processes and compositions are described for the use in smoking tobacco flavor and aroma augmenting, modifying, enhancing and imparting compositions and as smoking tobacco aroma or flavor imparting, augmenting or enhancing materials of a mixture of compounds having the generic structure: ##STR1## wherein X is a moiety selected from the group consisting of: ##STR2## and wherein R.sub.1 and R.sub.2 are different, one of R.sub.1 or R.sub.2 being methyl, and the other of R.sub.1 or R.sub.2 being ethyl, or mixtures of same, including (i) 2,4,6-triisobutyl-1,3,5-trioxane and (ii) 2-isobutyl dialkyloxazolines.
9	Flavoring with mixtures of 2,4,6-triisobutyl-1,3,5-trioxane and 2-isobutyl-dialkyl oxazolines	US928716	1978-07-27	US4191785A	1980-03-04	Donald A. Withycombe; Braja D. Mookherjee; Manfred H. Vock; Joaquin F. Vinals
Processes and compositions are described for the use in foodstuffs, chewing gums, toothpastes and medicinal product flavor and aroma augmenting, modifying, enhancing and imparting compositions and as foodstuff, chewing gum, toothpaste and medicinal product imparting, augmenting or enhancing materials of a mixture of compounds having the structures: ##STR1## wherein R.sub.1 and R.sub.2 are different and each represents ethyl or methyl. Addition of such mixtures to foodstuffs, foodstuff flavorings, chewing gums, toothpastes and medicinal products produces therein sweet, dark chocolate and cocoa powder-like aroma characteristics with dark chocolate, cocoa powder-like, and spicey flavor characteristics and bitter chocolate aftertastes.
10	Novel flavoring compositions and processes	US473370	1974-05-28	US3942537A	1976-03-09	William J. Evers; Joseph Sieczkowski
Processes for altering the flavors of consumable products, including foodstuffs and tobaccos, which comprise adding thereto a small but effective amount of at least one oxocyclic pyrimidine having the formula ##SPC1##Wherein R.sub.1 is alkyl, halogen or hydrogen and R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are the same or different and are hydrogen or alkyl; flavoring and flavor-enhancing compositions containing such oxocyclic pyrimidines; and novel oxocyclic pyrimidines and processes for the preparation of such oxocyclic pyrimidines.
11	Substituted thiazoles and flavoring processes and products produced thereby	US807054	1977-06-16	USRE29843E	1978-11-21	Alan O. Pittet; Denis E. Hruza
Processes for altering the flavors and/or fragrances of materials which comprise adding thereto effective amounts of at least one thiazole having the formula: ##STR1## wherein R is hydrogen, alkyl, or acyl; X is .Iadd.alkyl, .Iaddend.alkoxy, .Iadd.or .Iaddend.hydrogen, .[.or when R and Y are alkyl, alkyl;.]. and Y is alkyl, acyl, alkoxy or hydrogen, no more than two of R, X and Y being hydrogen; .Iadd.with the proviso that X is alkyl only when either (i) R and Y are each alkyl or (ii) Y is alkoxy; .Iaddend.compositions containing such thiazoles and compositions; perfumed materials containing such thiazoles and compositions; and novel thiazoles and processes for producing same.
12	Tobacco product	US575483	1975-05-08	US3996941A	1976-12-14	Charles W. Miller; James P. Dickerson; Charles E. Rix
Addition of substituted lactone compounds to tobacco to enhance the flavor and/or aroma thereof.
13	2-Methyl-5,7-dihydrothieno-[3,4d]-pyrimidine	US541259	1975-01-15	US3960860A	1976-06-01	Ira Katz; Richard A. Wilson; William J. Evers; Manfred H. Vock; Gerrit W. Verhoeve
This application relates to 2-methyl-5,7-dihydrothieno-[3,4d]-pyrimidine, which is useful for flavoring foodstuffs or tobacco compositions and altering the fragrance of perfume compositions.
14	Flavoring with an oxocyclic pyrimidine	US32567473	1973-01-12	US3857972A	1974-12-31	EVERS W; SIECZKOWSKI J
WHEREIN R1 is alkyl, halogen or hydrogen and R2, R3, R4, R5 and R6 are the same or different and are hydrogen or alkyl; flavoring and flavor-enhancing compositions containing such oxocyclic pyrimidines; and novel oxocyclic pryimidines and processes for the preparation of such oxocyclic pyrimidines. Processes for altering the flavors of consumable products, including foodstuffs and tobaccos, which comprise adding thereto a small but effective amount of at least one oxocyclic pyrimidine having the formula
15	Substituted thiazoles in flavoring processes and products produced thereby	US3769040D	1970-11-09	US3769040A	1973-10-30	PITTET A; HRUZA D
Process for altering the flavors and/or fragrances of materials which comprise adding thereto effective amounts of at least one thiazole having the formula WHEREIN R is hydrogen, alkyl, or acyl; X is alkoxy, hydrogen, or, when R and Y are alkyl, alkyl; and Y is alkyl, acyl, alkoxy or hydrogen, no more than two of R, X, and Y being hydrogen; compositions containing such thiazoles and compositions; perfumed materials containing such thiazoles and compositions; and novel thiazoles and processes for producing same.
16	Tobacco having an oxadiazole additive	US57141966	1966-08-10	US3410277A	1968-11-12	TORE DALHAMN

17	Methods for treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts	US189191	1998-11-10	US6110968A	2000-08-29	Richard J. Bucala; Helen Vlassara; Anthony Cerami; Carla J. Cerami; Henry W. Founds
Methods are provided for measuring the accumulation of advanced glycosylation endproducts (AGEs), and for lowering the accumulation of advanced glycosylation endproducts, which are predicated on the discovery that such AGEs and their precedent glycotoxins are present in tobacco and its byproducts. More particularly, the methods focus on the observation that individuals who smoke or otherwise use tobacco have increased levels of AGEs relative to non-smoking individuals. The present methods relate to the measurement of AGE levels in both individuals and in tobacco and its byproduct, smoke, and to the treatment of such individuals with agents capable of reacting with glycosylation products to either avert or diminish the accretion of AGEs in the body. Methods are also provided for the evaluation of the tobacco products to determine their storage status and organoleptic capacity and potential, for the treatment of the ambient atmosphere to lower AGE levels, and for the treatment of the tobacco products and combustion byproducts to lower AGE levels therein. For example, air or other samples may be taken and evaluated by a dosimeter or like device, to determine whether AGE levels exceed normal, after which measures could be implemented to remediate the ambient condition. Likewise, filters and similar devices for removing AGEs from tobacco smoke are provided. All such methods and corresponding materials are contemplated and included.
18	Methods for measurement and treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts	US772335	1996-12-23	US5850840A	1998-12-22	Carla J. Cerami; Richard J. Bucala; Helen Vlassara; Anthony Cerami; Henry W. Founds
Methods are provided for measuring the accumulation of advanced glycosylation endproducts (AGEs), and for lowering the accumulation of advanced glycosylation endproducts, which are predicated on the discovery that such AGEs and their precedent glycotoxins are present in tobacco and its byproducts. More particularly, the methods focus on the observation that individuals who smoke or otherwise use tobacco have increased levels of AGEs relative to non-smoking individuals. The present methods relate to the measurement of AGE levels in both individuals and in tobacco and its byproduct, smoke, and to the treatment of such individuals with agents capable of reacting with glycosylation products to either avert or diminish the accretion of AGEs in the body. Methods are also provided for the evaluation of the tobacco products to determine their storage status and organoleptic capacity and potential, for the treatment of the ambient atmosphere to lower AGE levels, and for the treatment of the tobacco products and combustion byproducts to lower AGE levels therein. For example, air or other samples may be taken and evaluated by a dosimeter or like device, to determine whether AGE levels exceed normal, after which measures could be implemented to remediate the ambient condition. Likewise, filters and similar devices for removing AGEs from tobacco smoke are provided. All such methods and corresponding materials are contemplated and included.
19	Smoking products comprising nicotine substitutes	US492256	1983-05-06	US4600025A	1986-07-15	Ronald E. Grigg; Kitti Amornraksa
A smoking product comprising an inert combustible substrate to which has been applied a nicotine-substitute-effective amount of a compound selected from the group consisting of 2-methyl-5-(pyrrolidinomethyl) thiazole and 2-methyl-5-(piperidinomethyl) thiazole, and the acid addition salts thereof. Thus, for example, a cigarette may include an inert combustible material which is a tobacco substitute onto which one or other effective compound has been impregnated.
20	Novel tobacco product comprising one or more sulfides and process	US730535	1976-10-07	US4083373A	1978-04-11	Joaquin F. Vinals; Jacob Kiwala; William J. Evers; Howard H. Heinsohn, Jr.
Described is a tobacco product having added thereto an amount sufficient to augment or enhance the flavor or aroma of the tobacco product particularly on smoking, of one or more sulfide compounds having the generic structure: ##STR1## wherein, when A is: ##STR2## B is: ##STR3## AND WHEN A is: ##STR4## B is: ##STR5## processes for producing such tobacco products and flavor formulations for use in conjunction with tobacco products containing one or more of such sulfide compounds.

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