| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 在流化态床制剂过程中监控药物成份特性的装置和方法 | CN01820738.3 | 2001-10-16 | CN1486420A | 2004-03-31 | S·福莱斯塔; J·约翰松; I·尼克拉松比约恩 |
| 本发明涉及一种方法和装置，用于在制剂期间监测流化态床装置的处理容器中的药物成份特性，其中测量装置(11，11’)对注入处理液的润湿区域(B)中的药物成份进行光谱分析测量。该方法还包括在光谱分析测量中使用一个光学探测设备，该探测设备能够传输从处理容器(1)中的监测区域发出辐射的二维图像。 | ||||||
| 2 | 监控药物成份性质的方法及用于其中的光学探测装置 | CN200710101277.3 | 2001-10-16 | CN101042338A | 2007-09-26 | S·福莱斯塔; J·约翰松; I·尼克拉松比约恩 |
| 本发明涉及一种方法和装置，用于在制剂期间监测流化态床装置的处理容器中的药物成份的性质，其中测量装置(11，11’)对注入处理液的润湿区域(B)中的药物成份进行光谱分析测量。该方法还包括在光谱分析测量中使用一个光学探测设备，该探测设备能够传输从处理容器(1)中的监测区域发出辐射的二维图像。 | ||||||
| 3 | 在流化态床制剂过程中监控药物成份特性的装置和方法 | CN01820738.3 | 2001-10-16 | CN1322324C | 2007-06-20 | S·福莱斯塔; J·约翰松; I·尼克拉松比约恩 |
| 本发明涉及一种方法和装置，用于在制剂期间监测流化态床装置的处理容器中的药物成份特性，其中测量装置(11，11’)对注入处理液的润湿区域(B)中的药物成份进行光谱分析测量。该方法还包括在光谱分析测量中使用一个光学探测设备，该探测设备能够传输从处理容器(1)中的监测区域发出辐射的二维图像。 | ||||||
| 4 | CORRECTION DEVICE, CORRECTION METHOD, AND DISTANCE MEASURING DEVICE | US15756712 | 2016-06-07 | US20180259629A1 | 2018-09-13 | TOYOHARU OOHATA; TAKAHIRO KOYAMA; TOMOKI ONO |
| Provided is a correction device including: a photon number counting unit that counts a photon number on the basis of an output signal output from a light receiving unit; a correction value acquiring unit that acquires a correction value corresponding to the photon number; and a correction unit that performs correction based on the correction value. | ||||||
| 5 | Light waveform measuring apparatus | US416774 | 1989-10-04 | US5071249A | 1991-12-10 | Akira Takahashi; Musubu Koishi; Yutaka Tsuchiya |
| A wavelength of light emitted from a semiconductor laser is shifted to a shorter wavelength with wavelength converting means and the resulting light of a shorter wavelength is applied to a sample. Upon exposure to the light of the shorter wavelength, the sample emits light of interest and its waveform is measured with measuring means. Fundamental wavelength laser light which passes through the waveform converting means is outputted therefrom in synchronism with the light of a shorter wavelength and detected by a first photodetector. The waveform of the light of interest can be measured correctly on the basis of an output signal from the first photodetector. | ||||||
| 6 | Streak tube with connection lead to reduce voltage propagation differences | US14354942 | 2012-08-07 | US09368315B2 | 2016-06-14 | Katsuyuki Kinoshita |
| A steak tube has a container with an entrance plate and an output plate, a photocathode disposed in the container and configured to emit electrons according to light to be measured, the light having been incident through the entrance plate, and a sweep electrode disposed in the container, having a pair of deflection plates for generating an electric field and a connection lead connected to each deflection plate, and configured to sweep the electrons in a sweep direction along the output plate. An opposing of edges of the deflection plate in a direction of the output plate are formed so as to extend in a direction from the entrance plate to the output plate, the connection lead has a first connection portion electrically connected to the deflection plate, and the first connection portion is connected to the opposing of edges. | ||||||
| 7 | STREAK TUBE | US14354942 | 2012-08-07 | US20140285085A1 | 2014-09-25 | Katsuyuki Kinoshita |
| A steak tube has a container with an entrance plate and an output plate, a photocathode disposed in the container and configured to emit electrons according to light to be measured, the light having been incident through the entrance plate, and a sweep electrode disposed in the container, having a pair of deflection plates for generating an electric field and a connection lead connected to each deflection plate, and configured to sweep the electrons in a sweep direction along the output plate. An opposing of edges of the deflection plate in a direction of the output plate are formed so as to extend in a direction from the entrance plate to the output plate, the connection lead has a first connection portion electrically connected to the deflection plate, and the first connection portion is connected to the opposing of edges. | ||||||
| 8 | Optical signal detector incorporating means for eluminating background light | US506782 | 1990-04-10 | US5043568A | 1991-08-27 | Yutaka Tsuchiya; Shinichiro Aoshima; Hironori Takahashi; Takuya Nakamura |
| A first part of input light containing both background light and signal light is extracted by a sampling streak tube and converted to a first electric signal by a photodetector. A second part of the input light containing only background light is extracted by the same sampling streak tube by offsetting the sampling timing and converted to a second electric signal by the photodetector. A signal component corresponding to the signal light is extracted by taking the difference between the first and second electric signals. In one embodiment, the sampling timing is offset by applying a chopping voltage to chopping electrodes provided in the sampling streak tube. | ||||||
| 9 | Light waveform measuring device including a streak camera | US460009 | 1990-01-02 | US5032714A | 1991-07-16 | Akira Takahashi; Musubu Koishi |
| Laser sources produce two light beams which are different in frequency and at least one of which is a pulse beam. The two light beams are subjected to sum frequency mixing in a non-linear optical element and a resultant sum frequency beam is applied to a specimen as an exciting pulse beam. A pulse beam separated from the sum frequency beam and synchronized therewith is detected by a photodetector. A measuring means measures a waveform of fluorescence light emitted from the specimen using an output of the photodetector as a measurement starting reference signal. According to one embodiment, the device operates in a single photon counting mode and the measuring means counts repeatedly an elapsed time from the detection of the measurement start reference signal to the detection of the fluorescence light for every divided section of the elapsed time. | ||||||
| 10 | Electro-optical streak camera | US351159 | 1989-05-12 | US4958231A | 1990-09-18 | Yutaka Tsuchiya |
| An electro-optical streak camera including an amplifier for amplifying a light signal under measurement. The amplified light signal is applied to an electro-optical deflector of a photodector portion of the streak camera. | ||||||
| 11 | Streak tube and streak device including same | US14354663 | 2012-08-07 | US08952604B2 | 2015-02-10 | Katsuyuki Kinoshita |
| A steak tube 1 has a container 2 with an entrance plate 2a and an output plate 2b; a photocathode 7 disposed in the container 2 and configured to emit electrons according to light to be measured, the light having been incident through the entrance plate 2a; a mesh electrode 3, a first focusing electrode 4, and an aperture electrode 5 forming an axially symmetric electron lens for focusing the electrons emitted from the photocathode 7, toward the output plate 2b; a sweep electrode 6 disposed in the container 2 and configured to sweep the electrons focused by the axially symmetric electron lens, in a sweep direction along the output plate 2b; and a second focusing electrode 9 disposed between the entrance plate 2a and the output plated 2b and forming a one-dimensional electron lens for focusing the electrons in the sweep direction. | ||||||
| 12 | STREAK TUBE AND STREAK DEVICE INCLUDING SAME | US14354663 | 2012-08-07 | US20140292183A1 | 2014-10-02 | Katsuyuki Kinoshita |
| A steak tube 1 has a container 2 with an entrance plate 2a and an output plate 2b; a photocathode 7 disposed in the container 2 and configured to emit electrons according to light to be measured, the light having been incident through the entrance plate 2a; a mesh electrode 3, a first focusing electrode 4, and an aperture electrode 5 forming an axially symmetric electron lens for focusing the electrons emitted from the photocathode 7, toward the output plate 2b; a sweep electrode 6 disposed in the container 2 and configured to sweep the electrons focused by the axially symmetric electron lens, in a sweep direction along the output plate 2b; and a second focusing electrode 9 disposed between the entrance plate 2a and the output plated 2b and forming a one-dimensional electron lens for focusing the electrons in the sweep direction. | ||||||
| 13 | Apparatus and method for monitoring characteristics of pharmaceutical compositions during preparation in a fluidized bed | US10399575 | 2003-09-15 | US20040057650A1 | 2004-03-25 | Staffan Folestad |
| The present invention relates to a method and apparatus for monitoring characteristics of a pharmaceutical composition during preparation thereof by in the process vessel (1) of a fluidized bed apparatus, wherein a measuring device (11, 11null) performs a spectometric measurement on the pharmaceutical composition in a wetting zone (B) into which a processing fluid is injected. The method also comprises the generic use of an optical probe device in spectrometric measurements, the probe device being capable of transmitting a two-dimensional image of radiation emitted from a monitoring area in the process vessel (1). | ||||||
| 14 | Photon-counting type streak camera device | US488861 | 1990-03-05 | US5043584A | 1991-08-27 | Musubu Koishi |
| A photon-counting type streak camera device measures by an integration operation the probability distribution of production timing of phenomenon light such as fluorescence light which a specimen produces upon reception of repeatedly generated pulse exciting light. A phenomenon streak camera system time-measures the phenomenon light, and a reference streak camera system time-measures reference light being synchronous with the exciting light. An arithmetic unit calculates the difference between outputs of the phenomenon and reference streak camera systems, so that the streak camera device can be prevented from being effected by a jitter or drift caused by a power change of a pulse light source. | ||||||
| 15 | Optical waveform observing apparatus | US291825 | 1988-12-29 | US4945224A | 1990-07-31 | Musubu Koishi; Etsuo Tsujimura; Motoyuki Watanabe; Yutaka Tsuchiya |
| Optical waveform observing apparatus including a sampling streak tube to which is applied an incident light beam having a waveform to be observed. An electron beam corresponding to the incident light beam is repetitively deflected in the streak tube, in response to a repetitive deflecting trigger signal, to sample the electron beam. The repetitive deflection of the electron beam is periodically stopped for a first time period. An integration circuit integrates data outputted by the streak tube. A subtraction circuit subtracts the integration of streak tube data outputted during the first time period from the integration of streak tube data outputted during a second time period when the repetitive beam deflection is not stopped, so that background noise and dark currents are not included in the subtraction result. | ||||||
| 16 | Streak camera apparatus | JP5553089 | 1989-03-08 | JPH02234049A | 1990-09-17 | KOISHI YU |
| PURPOSE: To improve time resolution by obtaining the difference of the results of an effect by the occurrence of drift and jitter in respective streak systems for phenomenon and reference. CONSTITUTION: Pulse light LB repeated in a specific cycle is branched to stimulating pulse light LB 1 and trigger pulse light LB 2 by a half mirror HM. The light LB 2 is received by a photodetector 5, where a trigger signal is generated to be transmitted to a sweep circuit 8. The light LB 1 is reflected and branched by a two-way mirror M 1. One of the branched light is set as reference pulse light LB 11, passes through a mirror M 2, a slit S 1 and a lens L 11 and is swept to be the reference of a trigger signal by a reference streak tube 4 1, and the other is set as stimulating pulse light LB 12 and made incident on a sample 3 to be generated to fluorescence PL being phenomenon light, which passes through a slit S 2 and a lens L 12 and is swept to be the reference of the trigger signal by a phenomenon streak tube 4 2. Temporal positions where reference and phenomenon streak image are respectively formed are detected 9 1 and 9 2 and the generation timing of the phenomenon light is computed 11 from the difference of respective outputs. COPYRIGHT: (C)1990,JPO&Japio | ||||||
| 17 | Light waveform observing instrument | JP16353787 | 1987-06-30 | JPS649325A | 1989-01-12 | KOISHI YU; TSUJIMURA ETSUO; WATANABE MOTOYUKI; TSUCHIYA YUTAKA |
| PURPOSE:To effectively remove the effect of a background noise and a dark current and obtain a highly accurate observed data by subtracting the integrated value of data obtained for a period wherein no deflected trigger signal is outputted from the integrated value of sampled data obtained during the deflected trigger signals are repetitively outputted. CONSTITUTION:The waveform of an incident light is observed by a sampling streak tube 1. At this time, an electric trigger signal TR with a repetitive frequency is delayed by a given time in a time sweep circuit 31, deflected 13 and outputted as a deflected trigger signal. Then, the output of the deflected trigger signal is stopped by a control circuit 32 via the circuit 31 and a blanking circuit 22 for the same period as that of the output of the deflected trigger signal. Data for the periods wherein the deflected trigger signal is outputted and is not outputted are integrated in a integration type amplifier circuit 34 and the integrated data only of a background noise and a dark current are subtracted from the integrated sampled data including the background noise and the dark current whereby data which are little affected by the background noise and the dark current can be obtained. | ||||||
| 18 | STREAK TUBE | EP12846760.2 | 2012-08-07 | EP2775505B1 | 2018-05-16 | KINOSHITA Katsuyuki |
| A steak tube has a container 2 with an entrance plate 2a and an output plate 2b, a photocathode 7 disposed in the container 2 and configured to emit electrons according to light to be measured, the light having been incident through the entrance plate 2a, and a sweep electrode 10 disposed in the container 2, having a pair of deflection plates 11, 12 for generating an electric field and a connection lead 13 connected to each deflection plate 11, 12, and configured to sweep the electrons in a sweep direction along the output plate 2b. An opposing of edges 11a, 11b of the deflection plate 11 in a direction of the output plate 2b are formed so as to extend in a direction from the entrance plate 2a to the output plate 2b, the connection lead 13 has a first connection portion 13a electrically connected to the deflection plate 11, and the first connection portion 13a is connected to the opposing of edges 11a, 11b. | ||||||
| 19 | Verfahren und Anordnung zur Multiparameter-Akquisition von Einzelphotonen zur simultanen Erzeugung von zeit- und orts- sowie zeit- und wellenlängen-aufgelösten Fluoreszenz-Bildern | EP02090321.7 | 2002-09-06 | EP1291627A1 | 2003-03-12 | Kemnitz, Klaus Dr. |
Die Erfindung betrifft ein Verfahren und eine Anordnung zur simultanen Erzeugung von zeitaufgelösten Fluoreszenzbildern (Fluoreszenz-Lebensdauer-Imaging) und zeitaufgelösten Emissionsspektren, basierend auf zeit- und orts-korrelierter Einzelphotonenzählung (ZOKEPZ) zur Bestimmung von Parametern bei Proben wie lebenden Zellen, in multi-well, in-vitro Fluoreszenz-Assays, in DNA-Chips, bei dem ein gepulster, hochfrequenter, polarisierter Laserstrahl auf eine Fluoreszenzprobe geleitet wird und das von der Fluoreszenzprobe emittierte Fluoreszenzlicht auf einen Strahlteiler (Intensitäts-, Farb-, bzw. Polarisationsteiler) gelenkt und dort in zwei Strahlzweige gespalten wird. Die Aufgabe der Erfindung, ein gattungsgemäßes Verfahren und eine Anordnung zu entwickeln, mit denen die beschriebenen Nachteile des Standes der Technik vermieden werden und mit denen Informationen zum Beispiel über makromole-kulare Wechselwirkungen in lebenden Zellen unter Bewahrung des ungestörten Lebens durch eine minimal-invasive Beobachtung unter Verwendung ultra-niedriger Anregungsenergien von ≤ 1mW/cm2 und ultra-niedriger Farbstoffkonzentrationen (1 Probenmolekül EB in 10.000 DNA Basenpaaren), gewonnen werden können, unter Vermeidung der durch Autofluoreszenz verursachten Artefakte, wird durch ein Verfahren gelöst, das dadurch gekennzeichnet ist, dass ein Strahlzweig (T1) durch ein Dispersionselement (11) und ein Neutral- (12) sowie Polarisationsfilter (20) auf einen orts- und zeit-korrelierten Einzelphotonen-Zählungs-Detektor (13) (OZKEPZ-Detektor) und der andere Strahlzweig (T2) durch ein Neutral-(14) sowie Farb- (22) und Polarisationsfilter (21) auf einen zweiten OZKEPZ-Detektor (15) geleitet wird, wobei in den Detektoren (13, 15) simultan Orts-/Wellenlängen-/Polarisations- und Zeitkoordinaten sowie die absolute Ankunftszeit der Einzelphotonen (Multi-Parameter Akquisitions-System) bestimmt werden, die in einer Kontroll-Elektronik (19) und PC gespeichert und ausgewertet werden. |
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| 20 | Dispositif de calibrage d'un photodétecteur rapide | EP91402571.3 | 1991-09-26 | EP0478458A1 | 1992-04-01 | Gontier, Dominique; Huilizen, Jean-Claude; Mens, Alain |
Ce dispositif de calibrage comprend une source lumineuse (30) pour émettre une impulsion lumineuse incidente, une fibre optique de calibrage (10) de longueur déterminée, possédant une première et une seconde extrémités (12, 14) polies, la première extrémité (12) étant arrangée pour recevoir l'impulsion lumineuse et la seconde extrémité (14) étant disposée en regard du photodétecteur et des moyens semi-réfléchissants (16, 17) disposés à chaque extrémité (12, 14) de la fibre optique de calibrage (10). Application au calibrage d'une caméra à balayage ou de tout autre photodétecteur rapide. |
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