| Document | Document Title |
|---|---|
| US11421234B2 |
Aptamers for targeting coagulation factor XIII and uses thereof
Provided herein is an aptamer specific to coagulation factor XIII (FXIII) and its uses thereof. Accordingly, the present aptamer is useful as a bio-tool to label thrombi, and/or as a targeting molecule to deliver drugs to thrombotic area. Therefore, the present disclosure also pertains to methods for treating diseases associated with FXIII, such as thrombosis. |
| US11421232B2 |
Compositions and methods for treatment of cardiac diseases
Disclosed herein include microRNA antagonists, therapeutic compositions that include one or more of such microRNA antagonists, and methods of treating and/or ameliorating cardiac diseases and/or muscular dystrophy disorders with the microRNA antagonists. Also included are combination therapies, wherein a therapeutic composition disclosed herein and an additional therapy agent are provided to a subject having or suspected of having cardiac disease and/or muscular dystrophy disorder. In particular, some embodiments disclosed herein relate to compositions and methods for transiently administering a mixture of microRNA antagonists for promoting cardiomyocyte proliferation and cardiac regeneration. |
| US11421225B2 |
Methods and systems for modulating intracellular gene expression
In an embodiment, a device for modulating intracellular gene expression, the device having a calcium actuator component and a transcription reprogramming component. In another embodiment, a method for modulating intracellular gene expression, where the method includes inducing a system having a calcium actuator component and a transcription reprogramming component with at least one of light and a chemical, causing an increase in Ca2+, and translocating the transcription reprogramming component from cytosol to the nucleus. In a further embodiment, a method for modulating gene intracellular expression, where the method includes inducing a system having an NIR-stimulable optogenetic platform with at least one of light and a chemical, where the NIR-stimulable optogenetic platform facilitates Ca2+ release and the NIR-stimulable optogenetic platform is LOV2-SOAR, causing an increase in Ca2+, and translocating a calcium-responsive dCas9 fusion construct from cytosol to the nucleus, where the calcium-responsive dCas9 fusion construct is NFAT1-460-dCas9-VP64. |
| US11421216B2 |
Nuclease-based RNA depletion
The present disclosure is related to methods and materials for depleting unwanted RNA species from a nucleic acid sample. In particular, the present disclosure describes how to remove unwanted rRNA, tRNA, mRNA or other RNA species that could interfere with the analysis, manipulation and study of target RNA molecules in a sample. |
| US11421215B2 |
Nucleic acid encoding an isomerase, host cells containing the nucleic acid, and methods of making and using the host cells
The present invention provides for a nucleic acid encoding an isomerase and uses of the isomerase for bioconversion of sugar substrates. The invention represents an advancement in the field of enzyme engineering and discloses a modified nucleic acid for achieving optimum expression of a protein having isomerase activity in a heterologous host. The invention also discloses vectors carrying the modified nucleic acid and recombinant host cells carrying the vectors. The invention also discloses the process for producing a recombinant host cell, process for production of the recombinant enzyme and the process for bioconversion of sugars into their respective isomers using the recombinant protein. |
| US11421212B2 |
Engineered yeast strains with signal sequence-modified glucoamylase polypeptides and enhanced ethanol production
The invention is directed to non-natural yeast able to secrete significant amounts of glucoamylase into a fermentation media. The glucoamylase can promote degradation of starch material generating glucose for fermentation to a desired bioproduct, such as ethanol. The glucoamylase can be provided in the form of a glucoamylase fusion protein having secretion signal that is: derived from at least AA 1-19 of SEQ ID NO: 73, (ii) an amino acid sequence of at least AA 1-19 of SEQ ID NO: 74, (iii) SEQ ID NO: 77 (An aa), (iv) SEQ ID NO: 75 (Sc IV), (v) SEQ ID NO: 76 (Gg LZ), or (vi) SEQ ID NO: 78(Hs SA). |
| US11421210B2 |
Chimeric and other variant beta-glucuronidase enzymes with enhanced properties
Chimeric and other variant β-glucuronidase enzymes with enhanced properties as compared to unmodified enzyme are provided. The enzymes of the invention advantageously exhibit enhanced enzymatic activity, enhanced substrate range, enhanced pH range, enhanced temperature range and/or enhanced enzyme stability. Methods of using the variant enzymes for hydrolysis of glucuronide substrates, including opiates and benzodiazepines, are also provided. |
| US11421209B2 |
Cells producing Fc containing molecules having altered glycosylation patterns and methods and use thereof
The present application relates to the field of glyco-engineering, more specifically to glyco-engineering of Fc-containing molecules, such as antibodies. It is shown herein that Fc-containing molecules with a specific glycosylation pattern have a considerably longer circulating half-life in vivo, without having an altered binding affinity for their respective antigen. This has therapeutic implications in reducing the frequency with which these molecules need to be administered, without affecting therapeutic efficacy. Also, cells are provided that can produce the Fc molecules with the desired glycosylation pattern. |
| US11421205B2 |
Alkaline laccase variants with improved properties
The present invention relates to laccase variants and uses thereof as eco-friendly biocatalysts in various industrial processes. More in particular, the invention relates to a polypeptide with laccase activity comprising an amino acid sequence that is at least 90% identical to the amino acid sequence according to SEQ ID NO: 1, wherein the polypeptide comprises at least one amino acid selected from the group consisting of Alanine, Proline, Aspartic acid, Isoleucine, Proline, Proline, Threonine and Proline at a position corresponding to of positions 253, 128, 384, 364, 292, 450, 33 and 322 in SEQ ID NO: 1 respectively. |
| US11421200B2 |
Microorganism of the genus Corynebacterium producing purine nucleotide and a method for producing purine nucleotide by using the same
The present disclosure relates to a microorganism of the genus Corynebacterium producing a purine nucleotide and a method for producing a purine nucleotide using the same. |
| US11421196B2 |
High density distributed three-dimensional electrode device
Disclosed herein is a high-density distributed three-dimensional electrode device and an associated electroporation method. The method includes applying an electric pulse of a first polarity to a first group of electrodes while simultaneously applying an electrical pulse of a second polarity to a remaining group of electrodes, and then applying an electric pulse of the first polarity on a second group of electrodes while simultaneously applying an electric pulse of the second polarity to the remaining groups of electrodes. The electrodes receiving the electric pulse of the first polarity being surrounded by the electrodes receiving the electric pulse of the second polarity, and the first polarity and the second polarity are opposite. |
| US11421194B2 |
Pumpless platform for high-throughput dynamic multicellular culture and chemosensitivity evaluation
The described invention provides an ex vivo dynamic multiple myeloma cancer niche contained in a pumpless perfusion culture device. The dynamic multiple myeloma cancer niche includes (a) a three-dimensional tissue construct containing a dynamic ex vivo bone marrow niche, which contains a mineralized bone-like tissue containing viable osteoblasts self-organized into cohesive multiple cell layers and an extracellular matrix secreted by the viable adherent osteoblasts; and a microenvironment dynamically perfused by nutrients and dissolved gas molecules; and (b) human myeloma cells seeded from a biospecimen composition comprising mononuclear cells and the multiple myeloma cells. The human myeloma cells are in contact with osteoblasts of the bone marrow niche, and the viability of the human myeloma cells is maintained by the multiple myeloma cancer niche. |
| US11421191B1 |
Acidic cleaner
Methods and compositions for cleaning industrial equipment (e.g. biofuel or corn ethanol plant equipment) in place at high temperatures using acidic methane sulfonic acid compositions having a low pH. |
| US11421189B2 |
Automatic dishwashing detergent composition
An automatic dishwashing cleaning composition having a new protease. |
| US11421187B2 |
Cleaning agent compositions containing copolymer
What are described are detergent compositions comprising one or more copolymers containing cationic structural units and macromonomeric structural units, and also one or more surfactants and water. The detergent compositions are especially suitable, in an advantageous manner, for producing shine on and imparting hydrophilic properties to the surface which has been treated with the detergent compositions. |
| US11421185B2 |
Solid fast draining/drying rinse aid for high total dissolved solid water conditions
The present invention is a solid rinse aid composition and methods of making and using the same. Applicants have surprisingly found that the crystal modifier sodium xylene sulfonate (short chain alkyl benzene or alkyl naphthalene sulfonates) at higher percentage can act as a solidification agent. The solid rinse aid composition generally includes a short chain alkyl benzene or alkyl naphthalene sulfonates solidification agent and an effective amount of a surfactant which can include a sheeting agent component, defoamer component and/or association disruption agent. The solid rinse aid composition may be phosphate-free, aminocarboxylate-free, and GRAS if desired. |
| US11421183B2 |
Process for refining vegetable oil with suppression of unwanted impurities
Process for refining vegetable oil, to suppress the formation of monochloropropanediol esters (MCPDe) and reduce the content of glycidyl esters, comprising first and second refinement stages, wherein the first refinement stage comprises: a) providing a crude vegetable oil having a combined MCPDe and glycidyl ester content below 0.2 ppm; b) degumming the crude vegetable oil to produced degummed vegetable oil; c) bleaching of the degummed vegetable oil with activated bleaching earth under reduced pressure to yield bleached vegetable oil; d) adding a base to the bleached vegetable oil and subsequent stripping and deodorizing under reduced pressure at a temperature below 255° C. to yield an intermediate refined vegetable oil; and a second refinement stage comprising the steps of: e) bleaching of the intermediate refined vegetable oil using activated bleaching earth under reduced pressure to yield a bleached vegetable oil; and f) deodorizing at a temperature below 220° C. to yield fully refined vegetable oil, wherein the fully refined vegetable oil has a combined MCPDe and glycidyl ester content below 4 ppm. |
| US11421178B2 |
Lubricating oil composition for air compressors, air compressor lubricating method, and air compressor
Provided is a lubricating oil composition for air compressors containing a polyalkylene glycol-containing base oil (A) and a rust-preventive agent (B), wherein the content of the polyalkylene glycol is 65.0% by mass or more based on the total amount of the composition. The lubricating oil composition is excellent in oxidation stability and also in rust prevention and storage stability. Also provided are an air compressor lubricating method and an air compressor using the lubricating oil composition. |
| US11421176B2 |
Grease composition and hub unit
A grease composition includes a base oil, a thickener, and an additive. The base oil contains a synthetic oil. The thickener contains a compound having a urea group. The additive contains a phosphoric compound, a calcium-based compound, and a hydrocarbon-based wax. A hub unit includes the grease composition enclosed therein. |
| US11421173B2 |
Resin composition and sliding member
A sliding member includes: a base material; a coating layer formed on the base material and made of a resin composition including: a binder resin including polyamideimide; PTFE dispersed in the binder resin; and at least one of graphite and MoS2 dispersed in the binder resin; wherein a surface roughness of the coating layer after a sliding test is equal to or less than the surface roughness of the coating layer before the sliding test. |
| US11421171B2 |
Lubricating base oil for fluid dynamic bearing
An object of the present invention is to provide an ester-based lubricating base oil for a fluid bearing that has a high viscosity index and excellent evaporation resistance, hydrolytic stability, and low-temperature fluidity. The present invention relates to a lubricating base oil for a fluid bearing containing a compound represented by general formula (1): wherein R1 represents a linear C2-C16 alkyl group, m represents an integer of 2 to 10, and n represents an integer of 4 to 14. |
| US11421169B2 |
Beneficiation of coal for storage, transportation, and gasification
This document describes methods for pretreating coal to create either a dried coal or a char product that is stable in the outdoor environment and is more efficient as a feedstock for gasification or other processes than the original coal. Embodiments of the methods include pulverizing and pelletizing the coal, and pretreating the coal pellets to obtain a stable pellet of either dried coal or a stable pellet of chared coal (coal char). The pellets created by the described methods have undergone deoxygenation and carbonization improving their handling and storage properties and, in some cases, energy density. Pore structures within the pellets are stabilized physically and chemically so that the uptake of moisture into dry coal, that leads to internal heat generation, is greatly reduced. Chars are also, therefore, stable against transitions from a dry state to a wet state and less prone to self-ignition. |
| US11421168B2 |
Methods for preparing fuel additives
An optimised method for preparing a fuel additive f is provided. The method comprises carrying out the following reaction: (c, d, e) Starting material c may be prepared using an optimised method which comprises carrying out the following reaction: (a, b, c) |
| US11421164B2 |
Dual catalyst system for ebullated bed upgrading to produce improved quality vacuum residue product
An ebullated bed hydroprocessing system is upgraded using a dual catalyst system that includes a heterogeneous catalyst and dispersed metal sulfide particles to improve the quality of vacuum residue. The improved quality of vacuum residue can be provided by one or more of reduced viscosity, reduced density (increased API gravity), reduced asphaltene content, reduced carbon residue content, reduced sulfur content, and reduced sediment. Vacuum residue of improved quality can be produced while operating the upgraded ebullated bed reactor at the same or higher severity, temperature, throughput and/or conversion. Similarly, vacuum residue of same or higher quality can be produced while operating the upgraded ebullated bed reactor at higher severity, temperature, throughput and/or conversion. |
| US11421162B2 |
Process for co-conversion of waste plastics and hydrocarbon feedstock
The present invention relates to a process for converting the waste plastics along with the petroleum feedstock in a Catalytic Cracking Unit, in particular a Fluid Catalytic Cracking Unit employed in petroleum refineries. The invention also provides a method and hardware system to enable waste plastic to fuel conversion along with hydrocarbon catalytic cracking. The invented process aims to convert any type of waste plastic including polystyrene, polypropylene, polyethylene, metal containing Polyethylene-Polypropylene multilayer plastics & other metal containing plastics along with the petroleum derived feedstock such as vacuum gas oil, reduced crude oil, vacuum residue etc. in catalytic cracking unit. |
| US11421157B2 |
Formulations for high selective silicon nitride etch
Compositions useful for the selective removal of silicon nitride materials relative to polysilicon, silicon oxide materials and/or silicide materials from a microelectronic device having same thereon are provided. The compositions of the invention are particularly useful in the etching of 3D NAND structures. |
| US11421155B2 |
Method for producing core-shell structure including CdSe core based on glyme solvent and core-shell structure including CdSe core produced thereby
The present invention relates to a method for producing a core-shell structure including a CdSe core based on a glyme solvent. The method of the present invention enables the production of a core-shell structure including a CdSe core in a simple and economical manner. The present invention also relates to a core-shell structure including a CdSe core produced by the method. The core-shell structure of the present invention includes a large amount of CdSe and is uniform in size. Particularly, the core-shell structure of the present invention can be coated on a flexible plastic substrate of an optical device or semiconductor device due to its high stability. |
| US11421154B2 |
Composition with enhanced luminescence
A composition for photoluminescence of the chemical formula M2(1-y-z)Yb2yRem2zADO5-xF2x, a method for producing said composition, and uses of said composition are provided. |
| US11421152B2 |
Tagged treatment polymers for monitoring antiscalant concentrations in industrial water systems
The present invention relates to a fluorescently-tagged (co)polymer useful as a scale inhibitor in industrial water systems. Said (co)polymer comprises a (i) reactive fluorescent compound selected from a diazole compound (ii) at least one monoethylenically unsaturated acid monomer, and (iii) optionally, at least one monoethylenically unsaturated acid-free monomer. |
| US11421151B2 |
Light emitting device and display device including quantum dot
A light emitting device including a semiconductor nanocrystal and a ligand bound to a surface of the semiconductor nanocrystal, wherein the ligand includes an organic thiol ligand or a salt thereof and a polyvalent metal compound including a metal including Zn, In, Ga, Mg, Ca, Sc, Sn, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Sr, Y, Zr, Nb, Mo, Cd, Ba, Au, Hg, Tl, or a combination thereof, and a display device including the light emitting device. |
| US11421148B1 |
Injection of tailored water chemistry to mitigate foaming agents retention on reservoir formation surface
Compositions and methods for treating a subterranean formation. The compositions can include positively and negatively charged divalent ions and a total dissolved solids concentration between 2000 and 3000 ppm. In some implementations, the composition includes calcium and magnesium ions. In some implementations, the composition includes sodium, chloride, and bicarbonate ions. In some implementations, the composition includes iodide, phosphate, or borate ions, or any combination thereof. Methods for treating the subterranean formation can include flowing a first aqueous solution that includes sodium ions into the subterranean formation and flowing a second aqueous solution that has a lower salinity than the first aqueous solution into the subterranean formation, where the second aqueous solution includes positively charged divalent ions, negatively charged divalent ions, and a total dissolved solids concentration between 2000 and 30000 ppm. |
| US11421146B2 |
Viscoelastic fluids and methods of use
A viscoelastic emulsion formed by combining at least one extended surfactant, a salt (e.g., brine), an oil, such as crude oil, diesel, kerosene, or a vegetable oil, and water, into a mixture comprising an oil-starved Winsor III microemulsion into which excess oil is dispersed. The viscoelastic emulsion may be combined with a proppant to form a fracking fluid. The viscoelastic emulsion may be used in various reservoir applications, such as hydraulic fracturing, or flooding for enhanced tertiary oil recovery, and in other applications such as, but not limited to, environmental remediation, or formation of consumer products. |
| US11421143B2 |
Method for removing iron sulfide and calcium carbonate scale
A method of removing a heterogeneous scale from a surface in fluid communication with a wellbore and/or subterranean formation comprising contacting the scale with a composition comprising tetrakis(hydroxmethyl)phosphonium sulfate (THPS) and N-(2-hydroxyethyl)ethylenediaminetriacetic acid (THEDTA) to dissolve the scale having a pH in the range of about 6.0 to 8.0. The composition is suitable to remove iron sulfide and calcium carbonate scale in the absence of corrosion resistance at a temperature up to about 150° C. Also, the composition may be used remove scale from surface pipe line and other petroleum oil handling equipment. |
| US11421141B2 |
Nanosheet polymer composite for water shutoff
A polymer composite hydrogel includes a polymer composite, water, an organic crosslinker, and a salt. The polymer composite includes a nanosheet filler dispersed throughout a polymerized polyacrylamide. The nanosheet filler includes one or more of zirconium hydroxide, zirconium oxide, titanium oxide, graphene oxide, non-functionalized graphene, and hexagonal boron nitride. Further, a weight ratio of the nanosheet filler to the polymerized polyacrylamide is between 1:99 and 1:9. The polymer composite hydrogel includes 0.5 to 6 weight percent of the polymer composite and 0.25 to 5 weight percent of the salt, the salt being a monovalent salt, a divalent salt, or a combination of monovalent and divalent salts. A method of preparing a polymer composite, a method of preparing a polymer composite hydrogel for water shutoff applications, and the associated method of forming a barrier to shut off or reduce unwanted production of water in a subterranean formation is also provided. |
| US11421138B2 |
Composition for heat cycle system, and heat cycle system
To provide a composition for a heat cycle system, which comprises a working fluid for heat cycle which has a low global warming potential and high stability, and which can replace R410A, and a heat cycle system employing the composition.A composition for a heat cycle system, which comprises a working fluid for heat cycle containing trifluoroethylene, and a stabilizer for preventing deterioration of the working fluid for heat cycle, such as an oxidation resistance-improving agent, a heat resistance-improving agent or a metal deactivator, and a heat cycle system employing the composition for a heat cycle system. |
| US11421133B2 |
Thermosetting conductive adhesive
A thermosetting conductive adhesive that can exhibit high conductivity (low connection resistance) when cured at a high temperature in a short time. The present invention also provides a thermosetting conductive adhesive that has excellent adhesive strength when cured at a high temperature in a short time. The thermosetting conductive adhesive according to the present invention includes components (A) to (D): component (A): a urethane-modified polyfunctional (meth)acrylate oligomer that is either an aromatic urethane-modified (meth)acrylate oligomer having six (meth)acryl groups in the molecule or an aliphatic urethane-modified (meth)acrylate oligomer having two (meth)acryl groups in the molecule; component (B): a monofunctional (meth)acrylate monomer; component (C): an organic peroxide; and component (D): conductive particles, in which when the component (A) is an aliphatic urethane-modified (meth)acrylate oligomer having two (meth)acryl groups in the molecule, the component (B) is a monofunctional acrylate monomer. |
| US11421130B2 |
Coating composition for extreme washable coatings comprising self-crosslinkable core-shell particles
A coating composition including: an aqueous dispersion of self-crosslinkable core-shell particles, where the core-shell particles include (1) a polymeric core at least partially encapsulated by (2) a polymeric shell having urethane linkages, keto and/or aldo functional groups, and hydrazide functional groups, where the polymeric core is covalently bonded to at least a portion of the polymeric shell, and an acrylic polymer, where the acrylic polymer is non-reactive with the polymeric core and the polymeric shell. A substrate coated with a coating formed from the coating composition and a method of improving stain resistance of a substrate are also disclosed. |
| US11421124B2 |
Ink, ink set, printing method, and printing device
An ink contains a coloring material, an organic solvent, a resin, and a compound represented by Chemical Formula 1 having a weight average molecular weight of from 390 to 610, where R1 represents a hydrocarbon group, and n represents an integer of 2 or greater. |
| US11421115B2 |
Composition for electroless plating underlying membrane
A composition for forming an electroless plating undercoat comprising: (A) a conductive polymer (B) one or more resins selected from the group consisting of a polyester polyol resin and a polyether polyol resin; and (C) a polyisocyanate compound. |
| US11421114B2 |
Precursors for forming heterophasic anti-fouling polymeric coatings
An aqueous precursor liquid for forming an anti-fouling heterophasic thermoset polymeric coating is provided. The precursor liquid includes a first fluorine-containing polyol precursor having a functionality >about 2 that forms a fluorine-containing polymer component defining a first phase in the coating. The precursor liquid also includes a second precursor that forms a second component present as a second phase. The first phase can be a continuous phase and the second phase can be a discrete phase, or the second phase can be the continuous phase and the first phase can be the discrete phase. The discrete phase includes a plurality of domains each having an average size of ≥to about 500 nm to ≤to about 25,000 nm. A crosslinking agent, water, and optional acid or base are also present. Methods of making anti-fouling heterophasic thermoset polymeric coatings with such precursors are also provided. |
| US11421113B2 |
Chemical products for surface protection
Some implementations of the present disclosure prevent, reduce or at least slow equipment fouling using passivation as a treatment prior to contacting metallic components with hydrocarbon containing fluid, that is, an environment where fouling occurs. For example, one implementation includes a method of passivating heat exchangers in a SAGD process or system using the compositions and compounds of the present disclosure. The composition may be applied to a component prior to its first inclusion in an online system or following placing the system offline for maintenance. The composition may be used to treat metallic equipment surface(s), for example, via contacting them with a suspension or solution of the composition described herein, prior placing the system online. The method may further include treatment of the process fluid, for example, via injection or batch treatment of the composition with the compositions described herein into the process fluid. |
| US11421110B2 |
Dyes, dye-sensitized solar cells, and methods of making and using the same
Provided herein are dyes, dye-sensitized solar cells, and sequential series multijunction dye-sensitized solar cell devices. The dyes include an electron deficient acceptor moiety, a medium electron density π-bridge moiety, and an electron rich donor moiety comprising a biaryl, a substituted biaryl, or an R1, R2, R3 substituted phenyl where each of R1, R2, and R3 independently comprises H, aryl, multiaryl, alkyl substituted aryl, alkoxy substituted aryl, alkyl substituted multiaryl, alkoxy substituted multiaryl, OR4, N(R5)2, or a combination thereof; each R4 independently comprises H, alkyl, aryl, alkyl substituted aryl, alkoxy substituted aryl, or a combination thereof; and each R5 independently comprises aryl, multiaryl, alkyl substituted aryl, alkoxy substituted aryl, alkyl substituted multiaryl, alkoxy substituted multiaryl, or a combination thereof. The solar cells include a glass substrate, a dye-sensitized active layer, and a redox shuttle. The devices include at least two dye-sensitized solar cells connected in series. |
| US11421106B2 |
Vesicle incorporating transmembrane protein
A vesicle incorporate a transmembrane protein, the vesicle forming material including a mixture of poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) and polyetheramine. The vesicle can generally withstand elevated temperature without substantial shrinkage of the diameter, which in turn results in maintenance of the water permeability virtually unaffected. Pluronic based vesicles have a large content of amino groups available on the surface illustrated by the larger zeta potential values available for crosslinking in the polyamide layer by chemical reaction with trimesoyl chloride (TMC). |
| US11421104B2 |
Hydrogenated rubber with improved performance in TPE compositions
New hydrogenated styrenic block copolymers, in particular styrene-ethylene/butylene-styrene copolymers (SEBS copolymers), with improved performance in thermoplastic elastomer compositions (TPE compositions), process for preparing said hydrogenated styrenic block copolymers, reprocessable TPE-S compositions made thereof, method for producing an article from said reprocessable TPE-S compositions and articles made of said reprocessable TPE-S compositions, in particular suitable for medical applications. |
| US11421103B2 |
Method for preparing graft copolymer powder
The present invention relates to a method for preparing a graft copolymer powder, which includes: performing emulsion polymerization of a conjugated diene polymer, an aromatic vinyl monomer and an alkyl (meth)acrylate monomer to prepare a graft copolymer latex; coagulating the graft copolymer latex; aging the coagulated graft copolymer; preparing a wet powder of the graft copolymer by dehydrating the aged graft copolymer; and adding poly(oxyalkylene)diglycolic acid to the wet powder of the graft copolymer. |
| US11421101B2 |
Aqueous resin dispersion, method for producing aqueous resin dispersion, aqueous coating material, and adhesive
An aqueous resin dispersion with which excellent adhesiveness to a polyolefin base material such as a polypropylene base material can be easily obtained, which can be baked at low temperature, and which is for producing an aqueous coating material; and an aqueous coating material and an adhesive which contain the aqueous resin dispersion, are provided. In an aqueous resin dispersion (C) of the present invention, an olefin polymer (A) and a polymer (B) containing a constitutional unit derived from a radically polymerizable monomer (b1) having a reactive functional group are dispersed in an aqueous medium, a median diameter of the aqueous resin dispersion (C) measured by a dynamic light scattering method is 300 nm or less, and a dry product of the aqueous resin dispersion (C) contains 1 mass % or more of an insoluble component (D) that is insoluble in tetrahydrofuran. |
| US11421100B2 |
Blends of linear low density polyethylenes
A polyethylene blend comprising a uniform dispersion of constituents (A) and (B): (A) a Ziegler-Natta catalyst-made linear low density polyethylene and (B) a metallocene catalyst-made linear low density polyethylene, a composition comprising the polyethylene blend and at least one additive, methods of making and using same, and manufactured articles and films comprising or made from same. |
| US11421098B2 |
Use of a depleted epoxidized fatty acid ester mixture as plasticizer in halogenated resins
The present invention relates to the use of a depleted epoxidized fatty acid ester mixture as plasticizer in a halogenated resin composition, said ester being obtainable by a process comprising epoxidation of a vegetable oil, transesterification of the epoxidized vegetable oil, short path distillation of the trans-esterified epoxidized vegetable oil and selection of the non-vaporized fraction of the preceding process step. The depleted ester mixture is suitable for being incorporated in halogenated resin compositions at a ratio exceeding 40 phr, without causing rheological or other problems to occur under practical industrial applications for the plasticized resin composition. |
| US11421094B2 |
Functionalized particulate bicarbonate as blowing agent, foamable polymer composition containing it, and its use in manufacturing a thermoplastic foamed polymer
A chemical blowing agent for foaming a thermoplastic polymer, for example PVC plastisol or a polymer resin in an extrusion process, comprising a functionalized particulate bicarbonate containing at least one additive, preferably excluding an exothermic blowing agent. The additive may be selected from the group consisting of polymers; inorganic salts; oils; fats; resin acids, any derivative thereof, and salts thereof; amino acids; fatty acids; carboxylic or polycarboxylic acids, soaps; waxes; derivatives thereof; salts thereof; or any combinations thereof. The particulate bicarbonate may be functionalized by spray-drying, coating, extrusion or co-grinding with at least one additive. The functionalized particulate bicarbonate may comprise 50 wt % to less than 100 wt % of the bicarbonate component, and 0.02-50 wt % of the additive. A foamable polymer composition comprising such chemical blowing agent. A process for manufacturing a foamed polymer, such as foamed PVC, comprising shaping and heating the foamable polymer composition, and a foamed polymer obtained by such process. |
| US11421093B2 |
Two-stage curable laminate
Provided is a two-stage curable laminate characterized in that a layer containing a high-hardness resin (B) is disposed on at least one surface of a resin layer (A) containing a polycarbonate resin (a1), a coating layer (Z) is disposed on the layer containing the high-hardness resin (B), and conditions (i) to (iii) above are satisfied. |
| US11421085B2 |
EPDM packaging system and process
The present disclosure provides a packaging process and the resultant package produced from the process. The process includes introducing, into a mixing device, pellets composed of ethylene/propylene/diene polymer (EPDM). The EPDM comprises greater than 60 wt % units derived from ethylene. The pellets have a residual moisture content from 500 ppm to 2500 ppm. The process includes adding a silica-based powder to the mixing device and coating at least a portion of the pellets with the silica-based powder. The process includes sealing a bulk amount of the coated pellets in a bag made of a flexible polymeric film. The process includes absorbing, with the silica-based powder, the residual moisture from the pellets, and preventing moisture condensation in the bag interior for a period from 7 days after the sealing step to 1000 days after the sealing step. |
| US11421079B2 |
Method for controlling polyimide backbone structure and method for producing polyimide
A method for controlling a polyimide backbone structure, including: in preparation of a polyimide through reaction of a diamine component and (1S,2R,4S,5R)-cyclohexanetetracarboxylic dianhydride in an organic solvent containing an aprotic amide solvent and a lactone solvent, adjusting one or more of reaction conditions of a mass ratio of the aprotic amide solvent and the lactone solvent, a reaction temperature, a reaction time, and an amount of the aprotic amide solvent, so as to convert a cis-structure derived from the (1S,2R,4S,5R)-cyclohexanetetracarboxylic dianhydride in the formed polyimide to a trans-structure derived from (1R,2S,4S,5R)-cyclohexanetetracarboxylic dianhydride corresponding to the reaction conditions, thereby controlling a proportion of the trans-structure. |
| US11421077B2 |
Bio-based and hydrophilic polyurethane prepolymer
A cleaned biobased polyoxyalkylene glycol polyol, wherein the cleaned biobased polyoxyalkylene glycol polyol is completely primary hydroxyl-tipped or end-grouped, further wherein the cleaned biobased polyoxyalkylene glycol polyol comprises less than 15 ppm sodium and potassium metals, and further wherein the cleaned biobased polyoxyalkylene glycol polyol comprises less than 0.5% water by weight. |
| US11421074B2 |
Adhesive material, and method of use thereof
An adhesive material which comprises an epoxy component including a first flame retardant and a curing component which includes an adhesion promoter and a second flame retardant The epoxy component and curing component are present in a ratio of about 1:1 and the adhesive is formed when the epoxy component is combined with the curing component. |
| US11421072B2 |
Photosensitive epoxy resin composition for formation of optical waveguide, curable film for formation of optical waveguide, optical waveguide produced by using the resin composition or the curable film, and hybrid flexible printed wiring board for optical/electrical transmission
A photosensitive epoxy resin composition for formation of an optical waveguide is provided, which contains an epoxy resin component, and a photo-cationic polymerization initiator, wherein the epoxy resin component includes a solid semi-aliphatic bifunctional epoxy resin. The optical waveguide formation photosensitive epoxy resin composition is usable as an optical waveguide forming material having higher R-to-R (roll-to-roll) adaptability (lower tackiness and uncured-state flexibility), a lower refractive index, excellent patternability, and excellent laser processability mirror forming processability). |
| US11421066B2 |
Polymer composition for stereolithography
An object of the present invention is to provide a novel polymer composition for stereolithography that is capable of suitably providing an elastic molded product by stereolithography. A polymer composition for stereolithography containing a liquid polymer and a monomer, the polymer composition for stereolithography having a viscosity of 3,000 mPa·s or less, the viscosity being measured in an environment of a temperature of 25° C. and a relative humidity of 50% using an E-type viscometer under conditions of a cone plate diameter φ of 25 mm and a shear rate of 100 sec−1. |
| US11421061B2 |
Zwitterion-containing membranes
Disclosed is a statistical copolymer that includes both zwitterionic repeat units and hydrophobic repeat units, and a filtration membrane that contains a selective layer formed of the statistical copolymer. Also disclosed are methods of preparing the above-described filtration membrane. |
| US11421060B2 |
Dope solution for preparing optical film and optical film using the same
Provided are a dope solution for preparing a polarizing plate protective film by a solution casting method using an acrylic polymer with high thermal resistance and high molecular weight, and a polarizing plate protective film using the same.The polarizing plate protective film using the dope solution according to the present invention has excellent optical properties, high tensile strength, low hygroscopic properties, and high thermal resistance, and thus, has the effects of excellent dimensional stability, and excellent adhesion with a polyvinyl alcohol film. |
| US11421054B2 |
Producing a polyethylene polymer
The present disclosure provides for a system and method for producing a polyethylene polymer (PE) that includes measuring a melt flow index (MFI) of the PE, comparing the measured value of the MFI to a predetermined desired range for the MFI, changing a catalyst feed rate to the polymerization reactor based on the compared values of the MFI, where changes in the catalyst feed rate preemptively compensate for subsequent changes in an oxygen flow rate to the polymerization reactor that maintain a predetermined residence time and bring the MFI of the PE into the predetermined desired range for the MFI; and changing the oxygen flow rate to the polymerization reactor thereby maintaining both the predetermined residence time and bringing the MFI of the PE into the predetermined desired range for the MFI. The measuring and comparing steps are repeated to ensure the measured value of the MFI is within the predetermined desired range of the MFI at the predetermined residence time. |
| US11421053B2 |
Conjugated diene-based polymer and method for preparing the same
A conjugated diene-based polymer catalyzed with a lanthanide rare earth element, and having high linearity and improved compounding properties, and a method for preparing the same are provided. The conjugated diene-based polymer catalyzed with a lanthanide rare earth element has high linearity, and if applied to a rubber composition, may show excellent processability, tensile strength and viscoelasticity. |
| US11421046B2 |
Aligned arrays of nanorods, and methods of making and using them
Described are methods for the assembly of monolayer, bilayer, or multi-layer structures composed of homogenous rod-like molecules and particles. Included are methods for tuning physical properties of the mono- or multi-layered structures by changing ionic conditions and the size or concentration of polymer used for self-assembly. |
| US11421044B2 |
Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto
Several embodiments of NO releasing structures are disclosed. In some embodiments, the structures are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of these structures. The covalently modified polymer structures may be tailored to release nitric oxide in a controlled manner and are useful for treatment of various medical conditions. |
| US11421043B2 |
Method for producing sieved low-substituted hydroxypropyl cellulose
There is provides a method for producing sieved low-substituted hydroxypropyl cellulose (L-HPC) at improved yield, while maintaining flowability and tablet properties. More specifically, there is provided a method for producing sieved L-HPC including a first sieving step of sieving L-HPC having a hydroxypropoxy group content of 5 to 16% by mass with a sieving shaker with horizontal movement of a sieve surface to obtain first sieve-residual L-HPC and first sieve-passed L-HPC, a second sieving step of sieving the first sieve-residual L-HPC with a sieving shaker with vertical movement of a sieve surface to obtain second sieve-residual L-HPC and second sieve-passed L-HPC, and a step of combining the first sieve-passed L-HPC and the second sieve-residual L-HPC to obtain the sieved L-HPC. |
| US11421038B2 |
RNA-coded antibody
The present application describes an antibody-coding, non-modified or modified RNA and the use thereof for expression of this antibody, for the preparation of a pharmaceutical composition, in particular a passive vaccine, for treatment of tumours and cancer diseases, cardiovascular diseases, infectious diseases, auto-immune diseases, virus diseases and monogenetic diseases, e.g. also in gene therapy. The present invention furthermore describes an in vitro transcription method, in vitro methods for expression of this antibody using the RNA according to the invention and an in vivo method. |
| US11421037B2 |
Nucleic acids encoding anti-CD154 antibodies
The present invention relates to antagonistic antibodies specifically binding CD154, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing. |
| US11421036B2 |
Methods of treating eosinophilic esophagitis by administering an antibody which inhibits interleukin-4 receptor (IL-4R)
The present invention provides methods for treating, preventing or reducing the severity of eosinophilic esophagitis. The methods of the present invention comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4Rα) inhibitor such as an anti-IL-4Rα antibody. |
| US11421034B2 |
Combination anti-CSF1R and anti-PD-1 antibody combination therapy for pancreatic cancer
The present invention relates to methods of treating pancreatic cancer with particular dosage regimes of antibodies that bind colony stimulating factor 1 receptor (CSF1R) (e.g. cabiralizumab) in combination with antibodies that bind programmed cell death 1 (PD-1) (e.g. nivolumab). |
| US11421033B2 |
Insulin immunoglobulin fusion proteins
Disclosed herein are immunoglobulin fusion proteins comprising an insulin therapeutic peptide and an immunoglobulin region that targets the insulin therapeutic peptide to the liver of an individual in need thereof. Further disclosed herein are compositions comprising the immunoglobulin fusion proteins and methods for using the immunoglobulin fusion proteins for the treatment or prevention of a disease or condition in a subject, for example, diabetes and diabetes related conditions. |
| US11421032B2 |
Compositions and methods for inhibition of MICA/B shedding
The present invention is based, in part, on the discovery of monoclonal antibodies, and antigen-binding fragments thereof, that specifically bind to MICA/B α3 domain, as well as immunoglobulins, polypeptides, nucleic acids thereof, and methods of using such antibodies for diagnostic, prognostic, and therapeutic purposes. |
| US11421029B2 |
Recombinant bispecific antibodies to PD-L1 and CTLA-4
Provided are a recombinant bispecific antibody against CTLA-4 and PDL-1, a nucleic acid molecule for encoding the antibody, a vector and a host cell comprising the nucleic acid molecule, and a method for preparing the antibody. Also provided are a pharmaceutical composition comprising the bispecific antibody, and usage of the bispecific antibody in preparation of the pharmaceutical composition. |
| US11421023B2 |
Anti-GP73 monoclonal antibodies and methods of obtaining the same
Disclosed herein are antibodies and methods of using said antibodies to detect Golgi protein 73 (GP73) and fucosylated GP73 in a sample. |
| US11421018B2 |
Full spectrum anti-dengue antibody
The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to DV epitopes, as well as compositions containing them and methods of designing, providing, formulating, using, identifying and/or characterizing them. In some embodiments, provided antibody agents show significant binding to a plurality of DV serotypes. In some embodiments, provided antibody agents show significant binding to all four DV serotypes. Such antibody agents are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of DV. |
| US11421017B2 |
Recombinant herpes simplex virus having expression cassette expressing fused protein of cancer cell-targeting domain and extracellular domain of HVEM and use thereof
The present invention relates to a recombinant herpes simplex virus (HSV) containing an expression cassette capable of expressing a fused protein of a cancer-cell-targeting domain and an extracellular domain of HVEM and the use thereof. When the recombinant HSV infects and enters target cells, which are cancer cells, HSV proliferates, and an adapter, which is the fused protein, is expressed in the cells and is released to the outside of the cells along with the proliferated HSV virion upon cell lysis, or is released even before the virion is released due to cell lysis when the adapter contains a leader sequence, and the fused protein released to the outside of the cells acts to induce the HSV virion to infect surrounding cancer cells expressing a target molecule recognized by the cancer-cell-targeting domain or to increase the infection efficiency thereof. |
| US11421015B2 |
Method of compact peptide vaccines using residue optimization
A system for selecting an immunogenic peptide composition comprising a processor and a memory storing processor-executable instructions that, when executed by the processor, cause the processor to create a first peptide set by selecting a plurality of base peptides, wherein at least one peptide of the plurality of base peptides is associated with a disease, create a second peptide set by adding to the first peptide set a modified peptide, wherein the modified peptide comprises a substitution of at least one residue of a base peptide selected from the plurality of base peptides, and create a third peptide set by selecting a subset of the second peptide set, wherein the selected subset of the second peptide set has a predicted vaccine performance, wherein the predicted vaccine performance has a population coverage above a predetermined threshold, and wherein the subset comprises at least one peptide of the second peptide set. |
| US11421014B2 |
Trifunctional T cell-antigen coupler and methods and uses thereof
A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis. |
| US11421012B2 |
Analogues of PYY
Analogues of PYY differing from native human PYY by substitution of Ser23 with Ala23, Glu23, Lys23, Gln23 or AIB23. Further optional features include substitutions at further positions, loss of the Tyr1 residue of native human PYY and amidation of the C-terminus. Suitable for use as pharmaceuticals for treating and preventing disorders, in particular diabetes and obesity. |
| US11421010B2 |
T cells expressing membrane-anchored IL-12 for the treatment of cancer
Provided herein are polypeptides comprising membrane-anchored IL-12. Also provided herein are T cells expressing the membrane-anchored IL-12. Further, methods of treating cancer comprising administering T cells expressing membrane-anchored IL-12 are provided herein. Also provided are combination treatments comprising T cells expressing membrane-anchored IL-12 and T cell chemoattractant-inducing chemokines. In addition, methods are provided for activating T cells to express NKG2D and methods of their use in the treatment of cancer. |
| US11421006B2 |
T cell epitopes from Cockroach and methods of making and using same
The invention provides Cockroach proteins, peptides, subsequences, portions, homologues, variants and derivatives thereof, and methods and uses and medicaments of such proteins, peptides, subsequences, portions, homologues, variants and derivatives thereof. Such methods, uses and medicaments include modulating an immune response, protecting a subject against or treating a subject for an allergic response, allergic disorder or allergic disease and inducing immunological tolerance to the allergen (e.g., Cockroach allergen) in a subject. |
| US11421005B2 |
Chimeric chlorotoxin receptors
The invention provides chimeric antigen receptor(s) (CAR(s)) that comprise a fusion protein of CTX or any functional variant thereof or a CTX-like peptide or any functional variant thereof as the extracellular antigen recognition moiety of the CAR. CAR(s) comprising CTX, a CTX-like peptide or functional variants of the foregoing are collectively referred to herein as “CTX-CAR(s).” Such CTX-CAR(s) may further comprise additional moieties or domains in the extracellular domain, a transmembrane domain and at least one intracellular! signaling domain. Such CTX-CAR(s) may be expressed in a host cell, such as, but not limited to, an immune effector cell. The present invention also provides methods of treatment (such as, for example, methods for treating cancer) by providing to the patient in need thereof immune effector cells that are engineered to express a CTX-CAR described herein. |
| US11421004B2 |
Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics
Provided are isolated polypeptides which are at least 80% homologous to SEQ ID NOs: 182-184, 186-202, 204-216, 219-223, 225, 227-232, 235-236, 238, 240-260, 262-268, 270-275, 277-287, 289-297, 3651-3671, 3686, 3720-3721, 3724, 3727, 3735, 3754, 3774, 3795-4304, 4316, 4374, 4425, 4464, 4481-4813, 4824, 4833, 4843-4844, 4867-4869, 4888, 4890-4891, 5005-5050, 5053-5070, 5093, 5217, 5231, 5233, 5239, 5246, 5255, 5257-5296, 5412, 5415-5429, 5447-5456, 5465-5673, 5675-5686, 5688-5695, 5697-5698, 5700, 5702-5707, 5709-5715, 5717-5785, 5831, 5869, 5980, 6010-6043, 6045-6053, 6055-6093, 6132, 6383, 6405, 6493, 6523, 6533-6537, and 6563-6589, isolated polynucleotides encoding same, nucleic acid constructs comprising same, transgenic cells expressing same, transgenic plants expressing same and method of using same for increasing yield, abiotic stress tolerance, growth rate, biomass, vigor, oil content, photosynthetic capacity, seed yield, fiber yield, fiber quality, fiber length, and/or nitrogen use efficiency of a plant. |
| US11421001B2 |
Template-fixed peptidomimetics
The template-fixed β-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-DPro-Pro), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity. |
| US11420998B2 |
Aromatic-cationic peptides and methods for using same
The present disclosure provides methods of preventing or treating renal ischemia-reperfusion injury in a mammalian subject and methods for chronic treatment of ARVD, including administering an effective amount of an aromatic-cationic peptide to a subject in need thereof. The methods include administering aromatic-cationic peptides to prevent or treat renal injury during the treatment of renal artery stenosis. The methods include administering an effective amount of an aromatic-cationic peptide to subjects in need thereof. |
| US11420994B2 |
Carbon-monoxide-releasing molecules and therapeutic applications thereof
Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and/or release of carbon monoxide occur at a temperature of about 37° C. and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described. |
| US11420988B2 |
Catalyst for asymmetric hydrogenation of compound containing carbon double bond
The present invention may provide an asymmetric hydrogenation catalyst capable of resolving enantiomers with excellent enantioselectivity from a carbon-carbon double bond-containing compound. The catalyst according to one embodiment of the present invention includes: an iridium cation; and a ligand bonded to the iridium cation. |
| US11420979B2 |
Organic compound, organic light emitting diode and organic light emitting device having the compound
Disclosed is an organic compound that includes a fused hetero aromatic moiety of a spiro structure as an electron donor and a triazine moiety as an electron acceptor that is linked to the electron donor via an arylene linker substituted with at least one electron withdrawing group, an organic light emitting diode and an organic light emitting device each of which applies the organic compound into at least one emitting unit. The organic compound enables the organic light emitting diode to increase its luminous efficiency and to improve its color purity. |
| US11420974B2 |
Substituted pyrrolizine compounds and uses thereof
This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them. |
| US11420973B2 |
Amide substituted indole compounds useful as TLR inhibitors
N-oxides, or salts thereof, wherein G, L2, R1, R5, R9, R10, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. |
| US11420972B2 |
Methods and compounds for treating Paramyxoviridae virus infections
Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections. |
| US11420971B2 |
Method for synthesizing amanitins
The invention relates to novel methods for synthesizing amanitin derivatives having an amino group attached to position 6′ of the central tryptophan moiety. The invention furthermore relates to a novel amanitin derivative having an amino group attached to position 6′ of the central tryptophan moiety, novel conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates. |
| US11420970B1 |
Piperidinyl-methyl-purineamines as NSD2 inhibitors and anti-cancer agents
The present invention provides a compound of Formula (I): or an enantiomer, an enantiomeric mixture, or a pharmaceutically acceptable salt thereof; wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating a disease or condition mediated by nuclear SET domain-containing protein 2 (NSD2). |
| US11420966B2 |
Substituted pyrrolopyridines as JAK inhibitors
The present invention relates to new pyrrolopyridine compounds having the structures of Formula (I)-(IV), wherein the R groups, A, B, C, D and n are as defined in the detailed description, and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis. |
| US11420965B2 |
Pyrimidine compound as JAK kinase inhibitor
The invention provides a compound of formula (I): or a pharmaceutically-acceptable salt thereof, that is an inhibitor of JAK kinases. The invention also provides pharmaceutical compositions comprising such compound, a crystalline form, methods of using such compound to treat inflammatory skin diseases and other diseases, and processes and intermediates useful for preparing such compound. |
| US11420964B2 |
Compositions and methods for modulating inflammatory and degenerative disorder
The disclosure provides compounds and method useful for modulating gp130 biological activity. The disclosure also provides methods and compositions for treating disease and disorders associated with gp130 activity, particularly those associated with inflammation. |
| US11420961B2 |
Heterocyclic compounds
The invention provides new heterocyclic compounds having the general formula (IA) wherein A, L, X, Y, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds. |
| US11420957B2 |
Substituted heterocycles as c-MYC targeting agents
Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders. |
| US11420956B2 |
Ureas having Androgen Receptor degradation activity and uses thereof
The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions. In some embodiments, the compounds disclosed herein exhibit androgen receptor degradation activity. |
| US11420954B2 |
Process for the separation of gallated epicatechins (EGCG and ECG) from green tea extract or green tea dust
The present invention relates to an improved process for the separation of gallated epicatechins (EGCG & ECG) from green tea extract or green tea dust. The present invention specifically relates to an improved process for the separation of gallated epicatechins (EGCG & ECG) from green tea extract or green tea dust by forming hydrated gallated epicatechins (EGCG & ECG)-isonicotinic acid complex using isonicotinic acid as acid, organic solvents for liberating gallated epicatechins. The present invention more specifically relates to the process for the separation of gallated epicatechins (EGCG & ECG) from green tea extract or green tea dust, wherein processes comprises steps of dissolving, concentrating by centrifugation, adding, precipitating, filtering, slurrying, removing supernatant liquid, washing, extracting and freeze drying. The present invention also relates to hydrated gallated epicatechins (EGCG & ECG)-isonicotinic acid complex. |
| US11420953B2 |
Co-crystal and/or eutectic crystal of kojic acid, compositions comprising the same, process of producing the same, and uses thereof
Novel co-crystal and eutectic crystal of kojic acid and a co-former that are excellent in physical properties are provided. In one aspect, novel co-crystals of kojic acid and a co-former that is maltol or ethyl maltol are provided. In another aspect, novel crystal of a eutectic mixture of kojic acid and a co-former that is selected from the group consisting of, maltol, ethyl maltol, methyl paraben and propyl gallate are provided. Methods for producing the novel co-crystal or eutectic crystal are also described. The novel co-crystals and eutectic crystals may be included in a pharmaceutical composition, a health food product or a medical food product for the treatment and/or prophylaxis of a neuropsychiatric disorder. |
| US11420949B2 |
Cystine diamide analogs for the prevention of cystine stone formation in cystinuria
Cystine analogs that improve the solubility of L-cystine in urine for treatment of cystinuria and which have the structure: and pharmaceutically acceptable salts, solvates and prodrugs thereof, wherein each R and R′ pair are independently selected from (i) or (ii); (i) R and R′ are independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alcohol, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic, and substituted or unsubstituted heteroaryl, or (ii) R and R′ together form a substituted or unsubstituted heterocyclic ring structure, or a substituted or unsubstituted heteroaryl ring structure; X is hydrogen, or an alkyl; and Y is O or S. |
| US11420947B2 |
(S)-n-hydroxy-2-(2-(4-methoxyphenyl)butanamido)thiazole-5-carboxamide and pharmaceutically acceptable salts thereof
The invention relates to the compound (S)-n-hydroxy-2-(2-(4-methoxyphenyl) butanamido)thiazole-5-carboxamide, which is a novel histone deacetylase inhibitor. The invention further relates to the use of the compound for the inhibition of histone deacetylating activities of HDAC isoforms and treatment of histone deacetylase (HDAC)-associated diseases. The invention also relates to the pharmaceutical compositions and the making of the pharmaceutical compositions comprising the compound. |
| US11420943B2 |
Peptide derivatives and therapeutic activity thereof
Disclosed are peptide or pseudopeptide derivatives containing a nitrogenous heterocyclic residue with blocking activity against the by-products of lipid oxidative stress, and in particular of unsaturated aldehydes such as malondialdehyde and 4-hydroxy-trans-2-nonenal (HNE). |
| US11420939B2 |
Method for preparing adrenochrome by catalytic oxidation using nitrogen-doped carbon nanotubes
Disclosed is a method for preparing adrenochrome by catalytic oxidation using nitrogen-doped carbon nanotubes. The method catalyzes dissolved oxygen in an aqueous solution by the nitrogen-doped carbon nanotubes to rapidly oxidize adrenaline, which is completely transformed into adrenochrome. It is a novel preparation process of adrenochrome, which is simple, and has mild reaction conditions, high product purity, an impurity content less than 10−8%, and low subsequent processing cost, thereby having a great application prospect. The nitrogen-doped carbon tubes after use can be regenerated and recovered, and its reutilization is still able to realize the complete transformation of adrenaline. The high utilization rate of catalytic material conforms to the concept of energy conservation, minimizing the costs. |
| US11420937B2 |
Urea plant with chilled condensation section
A urea production process comprising concentrating a first urea solution in a first vacuum evaporator in an evaporation section to give a urea melt and a first vapor, and condensing the first vapor in a first condensation section, wherein the first condensation section is a chilled condensation section, and a urea production system comprising the chilled condensation section. |
| US11420932B2 |
Method for preparing pregabalin intermediate (R)-3-(carbamoylmethyl)-5-methylhexanoic acid
A method for preparing pregabalin chiral intermediate (R)-3-(carbamoylmethyl)-5-methylhexanoic acid by a biological enzyme method. In particular, the method comprises: reacting compound (I) 3-isobutylglutaric acid, as a raw material, with a nitrogen-containing agent to produce compound (II) 3-isobutylglutarimide; and performing stereoselective ring-opening of compound (II) under the action of a biological enzyme to produce compound (III) (R)-3-(carbamoylmethyl)-5-methylhexanoic acid: |
| US11420927B2 |
Process for the manufacture of alkylfluoroacrylate
The invention relates to a process for the manufacture of an alkylfluoroacrylate starting from alkylfluoroacetate and an oxalic acid ester, wherein an alkane liquid under the reaction conditions is applied as the solvent in one of the reaction steps. |
| US11420926B2 |
Methods of making olefinic E- and Z-isomers
Method of making a second olefin using a first olefin, comprising steps (A) and (B): (A) performing a metathesis reaction with the first olefin in the presence of a metal complex configured to catalyse said metathesis reaction; (B) epoxidizing an olefin contained in the reaction mixture obtained in step (A) to form an epoxide; and deoxygenizing said epoxide to form said second olefin. |
| US11420924B2 |
Method for purifying organic acids
Provided is a method for purifying organic acids, including: a first extraction which includes separating an aqueous solution of organic acids into a first organic layer and a first aqueous solution layer by adding a solvent containing an amine and an alcohol; removing the alcohol from the separated first organic layer; and a second extraction which includes separating the first organic layer from which the alcohol has been removed into a second organic layer and a second aqueous solution layer by adding water. |
| US11420922B2 |
Hydroxylated tropolone inhibitors of nucleotidyl transferases in herpesvirus and Hepatitis B and uses therefor
The present disclosure relates to inhibitors of herpesvirus nucleic acid metabolism and inhibitors of Hepatitis B virus. Also provided are methods of treatment using these agents. |
| US11420920B2 |
Method for decreasing the concentration of a metal in a monomer composition comprising bis(benzoyl)benzene
Disclosed are methods of decreasing the concentration of a metal in a monomer composition including a bis(benzoyl)benzene, bis(benzoyl)benzene monomer compositions having a low total metal concentration, di-ketone polymers made from low metal bis(benzoyl)benzene monomers, and polymer compositions and shaped articles including the di-ketone polymers. It was surprisingly found that di-ketone polymers made by nucleophilic substitution of low metal bis(benzoyl)benzene monomers exhibit greater crystallinity, as compared with di-ketone polymers made with conventional monomers. |
| US11420917B2 |
Process for the manufacture of fluoroaryl compounds and derivatives
The invention relates to a new process for the manufacture of fluoroaryl compounds and derivatives thereof, in particular of fluorobenzenes and derivatives thereof, and especially wherein said manufacture relates to an environmentally friendly production of the said compounds. Thus, the present invention overcomes the disadvantages of the prior art processes, and in a surprisingly simple and beneficial manner, and as compared to the prior art processes, in particular, the invention provides a more efficient and energy saving processes, and also provides a more environmentally friendly process, for the manufacture of nuclear fluorinated aromatics, and preferably of nuclear fluorinated fluorobenzenes. Accordingly, in one aspect of the invention, an industrially beneficial process for preparing fluorobenzenes from halobenzene precursors using HF to form hydrogen halide is provided by the present invention. A beneficial and surprisingly simple use of chlorobenzene as an industrially interesting starting material in the manufacture of fluorobenzene is provided. |
| US11420910B2 |
Methods for low temperature fluorine-18 radiolabeling of biomolecules
New chelators such as H3L1, H3L2, H3L3, H3L26 and derivatives were synthesized for the complexation of {Al18F}2+. These new chelators are able to complex {AI18F}2+ with good radiochemical yields using a labeling temperature of 37° C. The stability of the new Al18F-complexes was tested in phosphate buffered saline (PBS) at pH 7 and in rat serum. AI18F-L3 and AI18F-L26 showed a stability comparable to that of the previously reported Al18F-NODA. Moreover, the biodistribution of Al18F-L3 and AI18F-L26 showed absence of in vivo demetallation since only very limited bone uptake was observed, whereas the major fraction of activity 60 min p.i. was observed in liver and intestine due to hepatobiliary clearance of the radiolabeled ligand. The chelators H3L3 and Al18F-L26 demonstrated to be a good lead candidates for the labeling of heat sensitive biomolecules with 18F-fluorine and derivatives have been synthesized. We have explored the complexation of {AI18F}2+ with new chelators and obtained very favourable radiochemical yields (>85%) using a labeling temperature of 37° C. The stability of the new Al18F-complexes was tested in phosphate buffered saline (PBS) at pH 7 and in rat serum at 37° C., where AI18F-L3 and AI18F-L26 showed a stability comparable to that of the previously reported Al18F-NODA. Moreover, the biodistribution of Al18F-L3 and Al18F-L26 showed high stability, since only very limited bone uptake—which would be an indication of release of fluorine-18 in the form of fluoride—was observed, whereas the major fraction of activity 60 min p.i. was observed in liver and intestines due to hepatobiliary clearance of the radiolabeled ligand. The chelators H3L3 and H3L26 demonstrated to be good lead candidates for the labeling of heat sensitive biomolecules with 18F-fluorine and several derivatives have been synthesized. |
| US11420908B2 |
Obtaining improved water fortifier from brewer's yeast water
A fortifier for growth and flowering in horticulture, trees and ornamental plants, aromatic plants and fruit trees, from wastewater from brewer's yeast with a very low protein concentration. The method including the step of: filtered by 80 μm; magnetic treatment of the liquid; addition of 0.1 to 20 g/l phosphate and 10 to 20 g/l glycose. Fermentation is carried out keeping the free amino acid content greater than 0.1%, the content of Mg+2 greater than 0.1%, total nitrogen, phosphate, and potassium below 3.0%, the content of protein from 0.5% to 1.0% and EDTA from 0.02% to 0.2%, all by dry matter weight; addition of microbes from the environment; at temperatures of 15° C. to 40° C. with gentle agitation, for 24 hours to 30 days; subsequent filtering and pH adjustment. It has been found to be effective in various crops. |
| US11420903B2 |
Glass article and display device including the same
A glass article includes a first surface, a second surface opposed to the first surface, a first compressive region extending from the first surface to a first compression depth, a second compressive region extending from the second surface to a second compression depth and a tensile region between the first compression depth and the second compression depth. A stress profile of the first compressive region includes a first segment located between the first surface and a first transition point and a second segment located between the first transition point and the first compression depth. A depth from the first surface to the first transition point ranges from 6.1 μm to 8.1 μm. A compressive stress at the first transition point ranges from 207 MPa to 254 MPa. A stress-depth ratio of the first transition point ranges from 28 MPa/μm to 35 MPa/μm. |
| US11420900B2 |
Localized control of bulk material properties
Electronic device components that include a glass portion and a ceramic or a glass ceramic portion are disclosed. The ceramic or glass ceramic portions of the component may be located to provide desired performance characteristics to the component, which may be an enclosure component. In addition, regions of compressive stress may be formed within the glass portion, the glass ceramic portion, or both to further adjust the performance characteristics of the component. Electronic devices including the components and methods for making the components are also provided. |
| US11420899B2 |
Colored alkali aluminosilicate glass articles
A glass article including at least about 40 mol % SiO2 and, optionally, a colorant imparting a preselected color is disclosed. In general, the glass includes, in mol %, from about 40-70 SiO2, 0-25 Al2O3, 0-10 B2O3; 5-35 Na2O, 0-2.5 K2O, 0-8.5 MgO, 0-2 ZnO, 0-10% P2O5 and 0-1.5 CaO. As a result of ion exchange, the glass includes a compressive stress (σs) at at least one surface and, optionally, a color. In one method, communicating a colored glass with an ion exchange bath imparts σs while in another; communicating imparts σs and a preselected color. In the former, a colorant is part of the glass batch while in the latter; it is part of the bath. In each, the colorant includes one or more metal containing dopants formulated to impart to a preselected color. Examples of one or more metal containing dopants include one or more transition and/or rare earth metals. |
| US11420897B2 |
High strain point and high young's modulus glasses
Substantially alkali free glasses are disclosed with can be used to produce substrates for flat panel display devices, e.g., active-matrix liquid crystal displays (AMLCDs). The glasses have high annealing temperatures and Young's modulus. Methods for producing substantially alkali free glasses using a downdraw process (e.g., a fusion process) are also disclosed. |
| US11420894B2 |
Brittle object cutting apparatus and cutting method thereof
A brittle object cutting apparatus and the method thereof are disclosed. Wherein, the brittle object cutting apparatus comprises a first heating laser unit, a second heating laser unit, a scribing laser unit, two cooling units and a processing module. A heating laser from the heating laser units respectively located on opposite sides of a scribing laser from the scribing laser unit, and a coolant of the cooling unit followed behind the heating laser. In the moving process of the brittle object, the processing module controls the scribing laser for a scribing operation, and controls one of the heating lasers and the coolant form one of the cooling units to heat and cool the brittle object. As a result, the machining time of dicing the brittle objects may be effectively reduced. |
| US11420893B2 |
Systems and methods for minimizing SHR from piercing during pharmaceutical part converting using a gas flow
Systems for producing articles from glass tube include a converter having a base with a plurality of processing stations and a turret moveable relative to the base. The turret indexes a plurality of holders for holding the glass tubes successively through the processing stations. The systems further include a gas flow system or a suction system for producing a flow of gas through the glass tube during one or more heating, forming, separating or piercing operations. The flow of gas through the glass tube produced by the gas flow system or suction system may be sufficient to evacuate or purge volatile constituents of the glass from the glass tube and/or pierce a meniscus formed on the glass tube during separation, thereby reducing the Surface Hydrolytic Response (SHR) of the interior surface of the glass tube and articles made therefrom. |
| US11420891B2 |
Systems, methods, and techniques for waste processing
A waste processing system includes a reactor including an inlet end and an outlet end configured to discharge reactor effluent. The inlet end includes a mixing unit having an oxidizing material input and a waste stream input. The reactor oxidizing material input is configured to receive reactor oxidizing material at a temperature greater than 200° C. and at a pressure greater than 60 atm. A second waste stream input is positioned between the reactor inlet end and the reactor outlet end. |
| US11420885B2 |
Electrolysis method and device for water
The invention relates to a easily adaptable or DIY installation water cleaning device on any existing spa or pool, said cleaning device including an electrolysis module equipped with a particular boron-doped diamond electrode on silicon substrate. The inventions also relates to a method to clean water on spa or pools using a water cleaning device comprising said particular boron-doped diamond electrode present on the elecrolysis module. The invention also relates to electrolyzed bathing water for use in the treatment of inflammatory diseases of the skin and for use for use in the treatment of wound healing of the skin. |
| US11420884B2 |
Irradiation device for irradiation reactor for treating a fluid and irradiation reactor
The invention provides an irradiation device (1) designed to be mounted to an irradiation reactor (20), comprising: an irradiation source (2), preferably an UV-LED, mounted on a heat conductive substrate (3); a disk-like heat sink (4) configured to removably receive the conductive substrate (3) such that heat transfer from the substrate (3) to the heat sink (4) is possible at a contact surface (4a) and such that the irradiation from the irradiation source (2) can pass through an opening (5) of the heat sink (4) into aninterior volume (21) of the irradiation reactor (20) when the irradiation device (1) is mounted to the irradiation reactor (20), wherein the opening (5) of the heat sink (4) is closed by a quartz window (6); fixation means (7) releasably biasing the substrate (3) against the contact surface (4a) of the heat sink (4); and a fluid channel (8) extending along and/or through the heat sink (4), wherein the fluid channel (8) is arranged to communicate with a fluid inlet or outlet port (22) of the irradiation reactor (20) and with one or more outlet openings (9) for discharging the fluid into the interior volume (21) of the irradiation reactor (20) or with one ore more inlet openings (9) for feeding the fluid from the interior volume (21) of the irradiation reactor (20) into the fluid channel (8). |
| US11420883B2 |
Method and system for controlling odor in water system
Methods and systems of controlling odor in. water by adding a humic composition to the water. The humic composition cm adsorb or otherwise neutralize malodorous compounds such as hydrogen sulfide, ammonia, and mercaptans. The methods are useful in food and. agricultural industries where the water may come in contact with food items. |
| US11420882B2 |
Water treatment system and method of use thereof
The present disclosure relates a system for the treatment of water. The water treatment system may be linked an aquatic protection system or a water filtration system. |
| US11420879B2 |
Conductive, anticorrosive magnesium titanium oxide material
An anticorrosive, conductive material includes a first oxide having oxygen vacancies and a formula (I): MgTi2O5-δ (I), where δ is any number between 0 and 3 optionally including a fractional part denoting the oxygen vacancies; and a second oxide having a formula (II): TiaOb (II), where 1<=a<=20 and 1<=b<=30, optionally including a fractional part, the first and second oxides of formulas (I) and (II) forming a polycrystalline matrix. |
| US11420875B2 |
Negative active material, preparation method thereof, and related secondary battery, battery module, battery pack and apparatus
This application belongs to the field of energy storage technology, and specifically discloses a negative active material including SiOx particles and a modified polymer coating layer covering the SiOx particles, in which 0 |
| US11420872B2 |
Graphene foam-based sealing materials
Provided is a graphene foam-based sealing material comprising: (a) a graphene foam framework comprising pores and pore walls, wherein the pore walls comprise a 3D network of interconnected graphene planes or graphene sheets; and (b) a permeation-resistant binder or matrix material that coats and embraces the exterior surfaces of the graphene foam framework and/or infiltrates into pores of the graphene foam, occupying from 10% to 100% (preferably from 10% to 98% and more preferably from 20% to 90%) of the pore volume of the graphene foam framework. |
| US11420866B2 |
Composite spring structure to reinforce mechanical robustness of a MEMS device
Various embodiments of the present disclosure are directed towards a microelectromechanical systems (MEMS) structure including a composite spring. A first substrate underlies a second substrate. A third substrate overlies the second substrate. The first, second, and third substrates at least partially define a cavity. The second substrate comprises a moveable mass in the cavity and between the first and third substrates. The composite spring extends from a peripheral region of the second substrate to the moveable mass. The composite spring is configured to suspend the moveable mass in the cavity. The composite spring includes a first spring layer comprising a first crystal orientation, and a second spring layer comprising a second crystal orientation different than the first crystal orientation. |
| US11420865B2 |
Fuel delivery system
A fuel delivery system having a base, a fuel inlet configured to receive fuel from a secondary fuel supply, a fuel outlet configured to deliver fuel to a machine, a filter assembly and a coalescer configured to filter the fuel, a fuel controller configured to regulate pressure of the fuel that will be delivered to a machine, a boost pump assembly and a main pump assembly configured to pressurize the fuel. |
| US11420863B1 |
System and method for operating a fuel dispensing apparatus
Smart fuel dispensing techniques utilize telematics data to initiate fueling sessions. Techniques can receive telematics data including identification data for a vehicle, determine a fuel type based on the vehicle identification data, determine a scope of fueling permissions associated with the vehicle identification data, and initiate a fueling session based on the scope of fueling permissions. |
| US11420860B2 |
Reconstitution of independent beverage flows
A dispensing assembly that can include first and second elements is provided. The first element can define a first outlet through which a first liquid is dispensed. The second element can define a second outlet through which a second liquid is dispensed. The first liquid can form an internal liquid stream when dispensed through the first outlet. The second liquid can form an annular liquid column around the internal liquid stream when dispensed through the second outlet. |
| US11420858B2 |
Personnel lift vehicle
The present disclosure relates generally to personnel lift vehicles that include a carriage, a telescoping lift and a load carrying frame. The telescoping lift is connected to a rear portion of the carriage and the load carrying frame is connected to and extends forward from the telescoping lift. The load carrying frame includes a bottom portion that provides an operator platform that is disposed at a central portion of the carriage between a front portion and the rear portion of the carriage. The configuration of the disclosed personnel lift vehicle provides an integral solution for counterweight requirements for the carriage while reducing the overall driving space required for the vehicle. |
| US11420856B2 |
Transport vehicle for transporting payloads
A transport vehicle for transporting payloads is provided. The transport vehicle includes primary and secondary chassis, and first and second sets of wheels for supporting the respective primary and secondary chassis. A guide arrangement is mounted on the primary chassis and the secondary chassis is slidably mounted on the guide arrangement. The primary and secondary chassis are parallel and spaced apart from each other. A payload lifting arrangement is positioned on a top surface of the secondary chassis to lift a payload. When a weight of the payload is below or equal to a threshold weight, the weight is distributed across the second set of wheels by way of the suspension arrangement. When the weight of the payload exceeds the threshold weight, the weight is distributed across the first and second sets of wheels by way of the guide arrangement and the suspension arrangement, respectively. |
| US11420855B2 |
Object detection device, vehicle, and object detection process
An object detection device configured to be mounted on a vehicle includes an object extraction unit that is configured to extract a point group that is a set of points representing a part of an object as the object, a neighboring object extraction unit that is configured to extract a neighboring object in an XY-plane of a world coordinate system, wherein the neighboring object is the object which is the closest to the vehicle, a coordinate transformation unit that is configured to transform coordinates of the neighboring object in the world coordinate system into coordinates of the neighboring object in an image captured by a camera, and a person determination unit that is configured to perform a person detection process in which it is determined whether or not the neighboring object is a person on the coordinates of the neighboring object. |
| US11420853B2 |
Assembly material logistics system and methods
System devices and methods for logistical handling and transfer of components and consumable assembly materials to support assembly or manufacturing operations. Through use of a transport vehicle having first and second container supports, the method allows in a component storage area and an assembly area, the transport vehicle both engaging or picking up a full or empty container and disengaging or depositing a full or empty container. In an alternate example, two separate transport vehicles can coordinatingly move together to engage or pick up a full or empty container and disengage or deposit a full or empty container in the component storage area or assembly area. |
| US11420851B2 |
Tower crane with automatic folding and unfolding stanchion
A tower crane configured to fold and unfold between a working configuration and a transport configuration includes a boom hinged in rotation relative to a mast about a main axis of rotation. The tower crane includes a rear retainer fastened to a frame supporting the mast and to a stanchion. The stanchion extends the boom rearwardly of the main axis of rotation and is displaceable relative to the boom between a working position and a transport position. The tower crane further includes a lifting cable connected to a winding device exerting, on the lifting cable, a tension force applied on stanchion by a return system configured to cooperate with the lifting cable, so as to cause displacement of said stanchion from the working position to the transport position. |
| US11420846B2 |
Augmented reality car operating panel
An elevator system is provided. Aspects includes an elevator car, a sensor, and a projector affixed to the elevator car, wherein the projector is operated by a controller and the controller is configured to receive an indication of a presence of a passenger in the elevator car. A car operating panel is projected, by a projector, in the elevator car, wherein the car operating panel comprises a virtual element. An activation of the virtual element from the passenger is sensed by a sensor and an action is initiated based at least in part on sensing the activation of the virtual element. |
| US11420839B2 |
Winding method and winding device of sheet-like belt
A winding method includes: attracting a sheet-like belt 8b onto a table 14 by multiple attracting means 15 lined up in a longitudinal direction of the sheet-like belt 8b; and winding the sheet-like belt 8b around a winding cylinder 50 by moving the winding cylinder 50 in the longitudinal direction of the sheet-like belt 8b while rotating the winding cylinder 50 above the sheet-like belt 8b and by cancelling attraction by the attracting means 15 one after another from attracting means 15 to which the winding cylinder 50 has moved. |
| US11420837B2 |
Sheet placement device, sheet feeding device, and image forming apparatus
A sheet placement device includes a placement member on which a sheet is placed; a limiter that is movable with respect to the placement member to limit a position of an end of the sheet placed on the placement member; a contact member provided in the limiter and to be displaced by contacting with the end of the sheet; and a detector that detects displacement of the contact member. The detector is provided in the placement member. |
| US11420836B2 |
Recording medium conveying device and image forming apparatus incorporating the recording medium conveying device
A recoding medium conveying device includes a conveyance belt, a first sensor, a second sensor, and circuitry. The conveyance belt has an endless loop shape and a length capable of conveying a plurality of recording media in one rotation. The first sensor is disposed upstream from the conveyance belt in a conveyance direction of a recording medium and is configured to detect the recording medium. The second sensor is configured to detect a home position of the conveyance belt. The circuitry is configured to adjust a rotation speed of the conveyance belt, while the conveyance belt makes one rotation, to eliminate an amount of deviation between a first detection timing of the recording medium detected by the first sensor and a second detection timing of the home position of the conveyance belt detected by the second sensor. |
| US11420834B2 |
Medium transport apparatus and image reading apparatus
A scanner is configured to include a rotating body at a bottom portion of an apparatus main body and to be switchable between a movable state in which the rotating body contacts an installation surface on which the apparatus main body is installed and the rotation of the rotating body enables the movement of the apparatus main body on the installation surface and an installation state in which a contact area of the bottom portion of the apparatus main body with respect to the installation surface is larger than the movable state and the apparatus main body is installed and used on the installation surface. |
| US11420830B2 |
Vacuum lifter
A vacuum lifter apparatus for lifting sheet material articles, comprises an upper chassis joined to a substantially planar lower suction plate and an airflow suction system for conveying vacuum air pressure to the suction plate. The suction plate comprises a plurality of suction plate modules, each comprising a housing with a substantially hollow interior and each of the housings being located laterally adjacent at least one other of the housings. Each of the housings comprises a lower plate, an upper plate and at least one side plate, each housing being affixed to the laterally adjacent housing along a seam between adjoining pairs of side plates. The upper plates each comprise at least one opening and the lower plates are each perforated with a plurality of orifices through which, in use, air is drawn along airflow paths through the interior and out of the opening by the airflow suction system. |
| US11420828B1 |
System and method for item singulation
Systems, methods, and computer-readable media are disclosed for systems and methods for item singulation in a conveyor belt system. The singulation system may include one or more conveyor belts, one or more piston arrays disposed below the one or more conveyor belts, one or more cameras for generating image data of the conveyor belt, and a computing device for processing the image data and controlling the piston array. The singulation system may selectively actuate pistons of the piston array to achieve singulation of the items (e.g., packages) on the conveyor belt to ensure such items are separated by a certain distance. Multiple conveyor belts in series and with increasing velocities may be employed to increase separation between items. |
| US11420826B2 |
Metal or rubber resonators for use in monitoring conveyor belt wear and longitudinal rip sensor systems
A system for detecting properties of a rubber product is disclosed. The system includes a dipole antenna and circuitry. The dipole antenna is configured to obtain antenna measurements and measure for a resonance frequency of a conductive resonator (200), wherein the dipole antenna (200) is positioned at a first position (A) and a second position (B). The circuitry is configured to determine one or more resonator properties (X) based on the antenna measurements. |
| US11420825B2 |
Method for monitoring the state of a conveyor system, and control unit, motorized roller, and conveyor system for carrying out the method
A method for state monitoring in a conveyor system, and also to a control unit, to a motorized roller, to a conveyor zone, to a conveyor section and to a conveyor system for carrying out this method. The method comprises checking for the presence of a reference operating state, determining a current of the motorized roller if the reference operating state is present, and comparing the determined current of the motorized roller with a reference value for the reference operating state. |
| US11420822B2 |
Container handling vehicle with direct drive on lifting axle(s), associated methods and system
An automated storage and retrieval system comprises a rail system comprising a first set of parallel tracks arranged in a horizontal plane and extending in a first direction, and a second set of parallel tracks arranged in the horizontal plane and extending in a second direction which is orthogonal to the first direction, which first and second sets of tracks form a grid pattern in the horizontal plane comprising a plurality of adjacent grid cells, each comprising a grid opening defined by a pair of neighboring tracks of the first set of tracks and a pair of neighboring tracks of the second set of tracks; and a plurality of stacks of storage containers arranged in storage columns located beneath the rail system. Each storage column is located vertically below a grid opening. A container handling vehicle comprises a transport mechanism for transport of the vehicle on the rail system, a lifting assembly for picking up storage containers from the storage columns to a position above the lowest level of the transport mechanism. The lifting assembly comprises a lifting frame connectable to a storage container, a first lifting shaft and a second lifting shaft, the first and second lifting shafts being mainly parallel, and each of the first and second lifting shafts being supported in an upper portion of the vehicle, two lifting elements extending from each of the first and second lifting shafts to the lifting frame, a motor drive assembly comprising at least a first motor, wherein the at least first motor encircles one of the lifting shafts, and a force transferring assembly rotatably connecting the first and second lifting shafts via a force transferring element. |
| US11420819B2 |
Automated waste collection system
An automated waste collection has a housing, within which is disposed a deployment mechanism for receiving a waste receptacle. The waste receptacle may be placed onto the deployment mechanism through an access opening traversing through the housing and selectively obstructed by an access closure. Waste may be deposited within the waste receptacle through a lid opening at a top of the housing. The deployment mechanism may be displaced by a deployment actuator between a stored position within the housing and a deployed position external to the housing. In order to do so, the deployment mechanism traverses through a deployment opening selectively obstructed by a deployment closure. A housing controller operates according to a predetermined waste collection schedule, actuating the deployment actuator at any scheduled waste collection times. The waste receptacle further has a set of motorized wheels that enable autonomous navigation from the housing to a collection position. |
| US11420817B2 |
Pressure vacuum vent
A pressure vacuum vent is disclosed which has a pressure plate having an opening, a diaphragm positioned on the pressure plate, a sealing ring for holding the diaphragm to the pressure plate, a sealing plate positioned on the diaphragm, a retaining ring for retaining the sealing ring, a screw having a cap having a vent opening, and a spring positioned between the cap and the sealing plate. |
| US11420808B2 |
Scented tissue product and method of making scented tissue product
[Object] A scented tissue product is provided that offers excellent tissue removability and that enables a scent to be felt continuously in a stable manner.[Solution] The object is achieved by a scented tissue product in which a fragrant film having a fragrance layer situated between a fragrance-permeable resin layer and a fragrance-impermeable resin layer is attached, separately from a film having a slit therein for covering a dispensing opening, to an area including at least part of an inner surface of the top face of a box member constituting a container box such that the fragrance-permeable resin layer faces a stack of tissues. |
| US11420803B2 |
Variable displacement base and container and method of using the same
Hot-fillable plastic bottle including a finished portion, a body portion with at least one circumferential rib configured to resist radial distortion, and a base portion. The base portion comprises a base sidewall, a bottom support surface extending radially inward from the base sidewall and defining a reference plane, an inner support wall extending upwardly from the bottom support surface, and a diaphragm extending radially inward from the inner support wall. The diaphragm comprises an inner wall having an arcuate shape with a radius r1 and a central conical structure, where the diaphragm is in an initial as-formed position with the conical structure above the reference place. The diaphragm is configured to move from an initial as-formed position toward a second position when an internal pressure relative an external pressure exceeds a threshold value. |
| US11420802B2 |
Blank for forming an article carrier
A blank (1)0 for forming an article carrier (90) has a main panel (12) which includes at least one article retention structure R1 having an aperture A1 defined in the main panel and one or more tabs formed about a periphery of the aperture in the main panel. The one or more tabs are connected to the main panel such that the tabs yield out of the plane of the main panel when an article is received in the aperture to bear against the article. The main panel includes a paperboard substrate and at least one polymeric layer. |
| US11420799B2 |
Triple shot shaker
Shaker will provide users a quicker and more efficient way to take their supplements before, during, and after their workouts. This delivery system will offer them the option to carry all three main supplements at once. |
| US11420797B2 |
Container closure and related methods
A container closure includes a dosage body including at least one peripheral wall defining a containment chamber. The peripheral wall has an internal wall surface adjacent the containment chamber, the internal wall surface having a surface luminance. Indicia is carried by the internal wall surface, the indicia having an indicia luminance. A contrast between the surface luminance and the indicia luminance is at least about 0.67% on the Weber scale. |
| US11420795B2 |
Ergonomic container with thumb hole
An apparatus includes a bottom wall, a plurality of connected walls attached to the bottom wall to define a cavity having a top rim, and a flange extending laterally outward from the top rim. At least a portion of the flange extends downwardly from the top rim. The portion of the flange includes an aperture configured to accept a user's thumb, and the portion of the flange is substantially symmetrical about a center line of the apparatus. |
| US11420792B2 |
Handle, and container with handle
Provided is a handle including an annular part configured to fit in a neck part of a container, a first extension part provided so as to be continuous with the annular part, and a first holding part provided so as to be continuous with the first extension part, in which the annular part includes a second contact part capable of coming into contact with a first contact part provided to the neck part, and the first extension part is configured to be positioned with respect to the container by the contact between the first contact part and the second contact part. |
| US11420790B2 |
Modular cargo system
A system for palletizing cargo includes a number of components that may be combined to produce an assembled pallet of cargo. A pallet base provides a cargo area where a payload may be stacked. The pallet base includes protective features such as feet that raise the payload above surface level, bumpers that prevent and absorb impacts to the pallet base, and a rim that encircles the cargo area. A pallet top is placed on top of the payload, opposite the pallet base, and a set of straps are used to connect the pallet base to the pallet top and friction fit the payload therebetween. Each of the base and top include a series of holes and spacers that allow airflow to pass around the bottom and top of the payload, while the bumpers allow airflow around the sides, even when the assembled pallets are surrounded by other cargo. |
| US11420786B1 |
Foldable drink cup carrier
A foldable drink cup holder that holds up to a dozen or more beverage cups as well as straws, and provides multiple layers of horizontal stabilization for the cups in addition to providing large footprints for text and graphics, including angled and square-cut corners structured to abut against each other when the holder is in a folded configuration to provide a flat side that is rigid and stable when holding multiple filled drink cups and straws. |
| US11420784B2 |
Food packaging articles
Containers and lids made from cellulose fibers and cellulose ester fibers are provided that have enhanced air permeability, stiffness, R-heat insulation values, or thickness at equivalent grammage basis weights are provided, or alternatively, maintaining one or more of these properties while lowering the basis weight of the containers or lids. The container and lids with this synthetic fiber can be biodegradable when made with cellulose ester fibers having a degree of substitution of not more than 2.5. Examples of such containers are food packaging such as hot or cold delivery boxes. |
| US11420774B2 |
Pointing mechanism
An artificial satellite includes two pointing mechanisms. The pointing mechanisms respectively include main body side gimbals, deployed booms, thruster side gimbals, and thruster groups. The main body side gimbal connects the deployed boom to a satellite main body and adjusts a direction of the deployed boom. The thruster side gimbal connects the thruster to the deployed boom and adjusts the direction of the thruster. Each gimbal is a two-axis gimbal. |
| US11420768B2 |
LED flash light source and runway-embedded flash lighting device
An LED flash light source for a runway-embedded flash lighting device, includes an LED module; a frame-shaped attaching plate; a lens member; and a shock-absorbing sheet, wherein the lens member is attached to a hollow portion in a frame of the frame-shaped attaching plate, the lens member is configured to allow an emission surface of a flash emitted from the LED module to have a uniform illuminance distribution, the shock-absorbing sheet includes: a lower shock-absorbing sheet; and an upper shock-absorbing sheet, the lower shock-absorbing sheet is disposed on the LED module, the frame-shaped attaching plate to which the lens member is attached is disposed on the lower shock-absorbing sheet, and the upper shock-absorbing sheet is disposed on the frame-shaped attaching plate. |
| US11420767B2 |
Runway-embedded flash lighting device and heat conducting member
A runway-embedded flash lighting device, includes a body configured to be embedded in a runway; a ceiling member including a flash emission window and disposed in an upper opening of the body and configured to be exposed to a runway surface when the body is embedded in the runway; a light guide member disposed in the flash emission window; an LED flash light source disposed inside the body and configured to emit a flash toward the light guide member; and a heat conducting member, wherein the light guide is configured to allow the flash emitted from the LED flash light source to be emitted from the flash emission window , the heat conducting member is disposed inside the body and includes a first part in contact with the LED flash light source, and a second part in contact with the ceiling member. |
| US11420764B1 |
Touchscreen fuel panel with checklist automation
A touchscreen fuel panel with checklist automation is disclosed. In embodiments, the fuel panel includes a touchscreen display and a controller coupled to the touchscreen display. The controller is configured to generate a graphical user interface at the touchscreen display and receive user inputs via the touchscreen display. The controller is further configured to execute an automated set of fuel management checklist procedures in response to a user input. In some embodiments, the controller can be alternatively or additionally configured to execute other automated sets of checklist procedures, for example, pre-flight, in-flight, taxi/takeoff/landing (TTL), and/or post-flight procedures. |
| US11420760B2 |
Sealed coaxial input and output shafts
A seal system for coaxially aligned shafts includes an input shaft and an output shaft coaxially aligned with the input shaft. The seal system includes a seal adapter support housing coupled to the output shaft and a seal positioned between an end of the input shaft and an end of the seal adapter support housing. The input shaft is configured to rotate at a speed that is different than a speed of the output shaft. |
| US11420759B2 |
Supersonic aircraft and method of reducing sonic booms
[Object] To provide a supersonic aircraft and a method of reducing sonic booms, by which sonic booms due to engine exhaust can be reduced.[Solving Means] A supersonic aircraft includes: a pair of engine nacelles 12R, 12L mounted on a fuselage 11 of an airframe 10; fins 13R, 13L as a pair of shielding plates that inhibits engine exhaust 15 discharged from jet engines (not shown) accommodated in the engine nacelles 12R, 12L from wrapping downward around the airframe 10; and a pair of horizontal tails 14R, 14L disposed behind the engine nacelles 12R, 12L. The fins 13R, 13L are disposed on the horizontal tails 14R, 14L so as to sandwich the engine exhaust 15, respectively. |
| US11420758B2 |
Multi-rotor noise control by automated distribution propulsion
A method of reducing noise generated by a tilt-rotor aircraft includes transitioning the tilt-rotor aircraft into an airplane mode from a helicopter mode, and reducing a speed of a first pair of fans of the tilt-rotor aircraft to be less than a speed of a second pair of fans that are positioned in-line with the first pair of fans. A flight control system configured to reduce a noise level of a tilt-rotor aircraft includes a flight control computer comprising a processor, a propulsion system communicatively coupled to the flight control computer, a first pair of fans and a second pair of fans communicatively coupled with the flight control computer and the propulsion system. The processor is operable to implement a method that includes transitioning the tilt-rotor aircraft into an airplane mode from a helicopter mode, and reducing a speed of the first pair of fans to be less than a speed of the second pair of fans that are positioned in-line with the first pair of fans. |
| US11420755B2 |
Shape memory alloy isolator for a gas turbine engine
A vibration isolation system for a gas turbine engine. The vibration isolation system includes a first fixed structure and a second fixed structure separate from the first fixed structure. The vibration isolation system further includes a connector coupling the first fixed structure to the second fixed structure. Additionally, the vibration isolation system includes an isolator, including a shape memory alloy material, associated with the connector. The isolator is arranged between the first fixed structure and the second fixed structure such that the isolator reduces vibrations transferred between the first fixed structure and the second fixed structure. |
| US11420747B2 |
Console mounted pilot tray assembly
A console mounted pilot tray assembly includes an aircraft cockpit having a console. A seat is mounted in the aircraft and faces the console. A side stick is mounted laterally to the console and a leg receiving space is positioned under the console. A mount is positioned under and is mounted to the console. The mount includes a guide rail. A panel has a top side, a bottom side, a front edge, a rear edge, a first side edge and a second side edge. A slide attached to the panel and is moveably mounted to the guide rail. The panel is moved along the guide rail and under the console to define a stored position. The panel is moved to a deployed position. The deployed position is defined as the panel extending outwardly away from the guide rail and the console. |
| US11420745B2 |
Aircraft oxygen mask container assembly
An oxygen mask container assembly that includes a container that defines a container interior and includes a container opening, an oxygen mask assembly disposed in the container interior, a mask ejector in operative communication with the mask assembly, a cover assembly that is movable between a closed position where the cover assembly covers the container opening and an open position where the mask can be ejected through the container opening and from the container interior, and a latch assembly. The oxygen mask assembly includes a mask and a lanyard. The cover assembly includes a light assembly therein that is configured to shine light below the cover assembly. The latch assembly is configured to move the cover assembly between the closed position and the open position. |
| US11420742B2 |
Unmanned aerial vehicle driven by pressurized content
A content-driven and content delivery UAV system. The UAV system includes a content source to provided pressurized content to the UAVs via a content transmission media. The pressurized content is utilized to drive a mechanical propulsion and steering system to keep the UAV aloft and direct it to a particular location. The pressurized content received by the UAVs can be directed back to the content source, to another UAV and or discharged from the UAV to a desired target. Thus, the UAVs may include a nozzle or valve for discharging the content and thus delivering the content to a desire location. |
| US11420735B2 |
Multi-rotor noise control by automated distribution propulsion
A method of reducing noise generated by a tilt-rotor aircraft includes transitioning the tilt-rotor aircraft into an airplane mode from a helicopter mode, and reducing a speed of a plurality of rotor blades of a first pair of rotors of the tilt-rotor aircraft to be less than a speed of a plurality of rotor blades of a second pair of rotors that are positioned forward of and in-line with the first pair of rotors. A flight control system configured to reduce a noise level of a tilt-rotor aircraft includes a flight control computer comprising a processor, a propulsion system communicatively coupled to the flight control computer, a first pair of rotors and a second pair of rotors communicatively coupled with the flight control computer and the propulsion system. The processor is operable to implement a method that includes transitioning the tilt-rotor aircraft into an airplane mode from a helicopter mode, and reducing a speed and/or pitch of a plurality of rotor blades of the first pair of rotors to be less than a speed and/or pitch of a plurality of rotor blades of the second pair of rotors that are positioned forward of and in-line with the first pair of rotors. |
| US11420728B2 |
Aircraft and control method for same
An aircraft and a control method therefor. The aircraft has: a velocity acquisition unit that acquires the velocity of the aircraft; a roll angle calculation unit that calculates the roll angle of the aircraft; a turning radius calculation unit that calculates the turning radius of the aircraft on the basis of the velocity and the roll angle; and a yaw rate calculation unit that calculates the yaw rate of the aircraft on the basis of the velocity and the turning radius. A control unit controls flight of the aircraft on the basis of the roll angle and the yaw rate. |
| US11420718B2 |
Aircraft tail assembly
An aircraft tail assembly includes an aft fuselage section secured to a forward fuselage section, and includes a stiffener-reinforced pivot bulkhead defined by separate parts secured together by a first set of splices. A longeron extends longitudinally along the aft and forward fuselage sections, and includes a discontinuity adjacent a peripheral edge of the pivot bulkhead. The aircraft tail assembly includes a second set of splices that overlie the discontinuity. One of the second set of splices extends laterally over the longeron to bridge the discontinuity adjacent the peripheral edge of the pivot bulkhead, and another of the second set of splices extends longitudinally along the longeron to secure the longeron to the pivot bulkhead adjacent the discontinuity. A chord engages the peripheral edge of the pivot bulkhead to facilitate transfers of force loads from the bulkhead along a load path that includes the longerons and the splices. |
| US11420713B2 |
Buoy reservation system
A mooring buoy reservation system is disclosed. The system comprises a mooring buoy that has the ability to enable or disable a tie up point on the buoy. The buoy has a microprocessor in communication with a server. And the server is in communication with a boat device.Also a method of a subscriber reserving a buoy through the server, paying for the buoy's use, and mooring to an enabled buoy is disclosed. |
| US11420710B2 |
Electromechanical rear derailleur
An electromechanical rear derailleur is provided for a bicycle, including a base member for attachment to the bicycle. A movable member has a cage assembly attached thereto. A linkage is provided that couples the movable member to the base member and operative to enable movement of the movable member relative to the base member in a direction substantially parallel to the mounting axis. A power source powers an motor module connected thereto to move the movable member and elements thereon. |
| US11420705B2 |
Handlebar
A handlebar for controlling a travelling direction of a vehicle includes: a transverse support extending along a first axial direction; a first grippable element extending from a first end of the transverse support and having a free end; a cavity in the transverse support or the first grippable element, the cavity communicating with: an opening in an external surface of the transverse support or the first grippable element, and a cavity entrance in an external surface of the transverse support or the first grippable element, wherein the cavity entrance is spaced from the opening; and a mounting arrangement including a mounting plate within the cavity, the mounting plate including: a first face abutting a contact surface within the cavity and is accessible via the opening; a second face opposite to the first face and accessible via the cavity entrance; and a hole for receiving a fastener for mounting an attachment. |
| US11420696B2 |
Vertically stowable trailer
A trailer includes a set of removable castor wheels attached to a rear portion thereof, wherein the castor wheels are oriented to face rearwardly when the trailer is oriented in the traditional horizontal position. This arrangement allows the trailer to be tilted upwardly into a vertical orientation so that it rests on the castor wheels, thus providing an apparatus and method for easily moving and storing trailers more efficiently due to the reduced footprint required for such trailer storage. The castor wheels, in one embodiment, include mounting brackets that may be attached to the trailer using a securing rod, similarly to the mounting mechanisms commonly used for removably attaching trailer hitches into trailer hitch sleeves, thus rendering the castor wheels removable from the trailer when they are not in use for storage purposes. |
| US11420690B2 |
Aerodynamic skirt securing connector with angular assembly capability
A skirt securing connector assembly for securing an aerodynamic skirt panel to a trailer is provided, the skirt securing connector assembly comprising an upper attachment portion adapted to secure the skirt securing connector assembly to the trailer, a lower attachment portion adapted to secure a lower portion of the aerodynamic skirt panel and a strut member connected, at a first end thereof, to the upper portion of the skirt securing connector assembly and connected, at a second end thereof, to the lower portion of the skirt securing connector assembly, the strut member including a longitudinal axis between the first end and the second end, the strut member including a concave portion extending along the longitudinal axis, the concave portion increasing an inertia moment of the strut member to sustain a force applied by air routing on the aerodynamic skirt. |
| US11420685B2 |
Vehicle body
The disclosure provides a vehicle body capable of well preventing the deformation of a side door even if the weight of the vehicle itself increases. The vehicle body includes a front pillar upper which extends rearward and upward along a side edge of a windshield, a front pillar lower which is joined to a lower end of the front pillar upper to support a front end of the side door, a dash upper side which connects an upper member to the front pillar lower while being joined to the front pillar upper at a rear extension part, and a front pillar upper stiffener which reinforces the bending rigidity of the front pillar upper. A distance is set between the rear extension part of the dash upper side and a front end of the front pillar upper stiffener above the front pillar lower. |
| US11420684B2 |
Front end structure
What is provided is a front end structure which can secure a strength and rigidity of a frame portion and reduce a weight thereof. The front end structure includes a frame portion (45), a vehicle body mounting portion (46), and a duct portion (42). The frame portion is formed to cover outer peripheral portions of a radiator and a condenser disposed in front of the vehicle body. The vehicle body mounting portion is provided on the frame portion and is connected to a front end of a front side frame (23) which extends in a forward and rearward direction of a vehicle body. The duct portion is continuous with the front end of the frame portion, and at least a part thereof is disposed above the vehicle body mounting portion and forms a continuous flow path between the duct portion and the condenser in a vertical direction. The frame portion, the vehicle body mounting portion, and the duct portion are integrally formed. |
| US11420682B2 |
Vehicle-body structure of vehicle
In a vehicle having a large side door opening, a vehicle-body structure suppresses, during a collision in which an apron reinforcement recedes, bending deformation of a hinge pillar at a mounting portion of the apron reinforcement. Embodiments include a reinforcement member inside a closed cross-section of a hinge pillar overlapping a mounting portion of an apron reinforcement in the up-down direction. The reinforcement member includes a body extending in the up-down direction spaced apart from the hinge pillar, a front flange portion at a front portion of the body, a lateral flange portion at a rear portion of the body, a front ridge portion between the body and the front flange portion, and a rear ridge portion between the body and the lateral flange portion. Each of the front ridge portion and the rear ridge portion is continuously provided over the reinforcement member in the vehicle up-down direction. |
| US11420678B2 |
Traction assist display for towing a vehicle
A traction assist apparatus includes a memory and a hardware processor coupled to the memory. The hardware processor is configured to: acquire first coupling information representing a current coupling posture of a towed vehicle to a towing vehicle and acquire second coupling information representing a future coupling posture of the towed vehicle where the towing vehicle moves backward at a current steering angle; and display a first indicator and a second indicator on a display device in a comparable mode, the first indicator indicating the towed vehicle corresponding to the first coupling information, the second indicator indicating the towed vehicle corresponding to the second coupling information. |
| US11420677B2 |
Mounting assembly for a steerable wheel with variable track width
A wheel-mounting assembly for an agricultural utility vehicle includes a chassis and a telescopic axle arrangement fixed to the chassis. The telescopic axle arrangement includes an inner axle telescopically received in an outer axle, which is fixed to the chassis. A wheel-support assembly is mounted to an outboard end of the inner axle. A steering-control actuator is connected between the inner axle and the wheel-support assembly. The steering-control actuator is connected to the inner axle through an opening provided in the outer axle, which allows the steering-control actuator to translate together with the inner axle when track width is adjusted. |
| US11420675B2 |
Multidirectional transport vehicle
A multidirectional transport vehicle includes a longitudinal axis which defines a longitudinal direction, a transverse axis which defines a transverse direction, a steering system, a driving direction switch, and a driving direction adjustment element. The steering system comprises at least three independently steerable wheels and a steering target value transmitter which steers the wheels. Each wheel has a wheel axle. A steering pole, on which each wheel axle is aligned when cornering, is moved along a steering pole axis by actuating the steering target value transmitter. The driving direction switch includes a limited number of separate switch positions, wherein exactly one switch position preselects exactly one respective rotational position of the steering pole axis relative to the multidirectional transport vehicle and preselects one of two driving directions facilitated thereby. The driving direction adjustment element changes a preselectable rotational position of the steering pole axis. |
| US11420672B2 |
Power conversion device, motor drive unit, and electric power steering device
A power conversion device includes a first converter connected to first ends of windings of each phase of a motor, a second converter connected to second ends of the windings of each phase, and a switching circuit used to define a neutral point in the windings of each phase on the first inverter side. At least one of a plurality of switches included in the first inverter has a first current capacity, and a plurality of switches included in the second inverter have a second current capacity that is greater than the first current capacity. |
| US11420671B2 |
Turning unit
A ball screw nut has a pair of through holes and a first passage that allows the through holes to communicate with each other and that opens radially outward. In each of the through holes, a ball screw mechanism has a circulation member having a second passage in which a ball can move between a ball raceway and the first passage. The ball screw mechanism has a circulation path for communicating the two connection points set on the ball raceway by the first passage and each of the second passages. A driven pulley has a thin portion that defines a radial clearance between an inner periphery of the driven pulley and an outer periphery of the ball screw nut. The ball screw mechanism has a pressing lid that presses down each of the circulation members from the outer periphery of the ball screw nut and that covers the first passage. |
| US11420669B2 |
Adjustment lever deceleration assembly for a steering column
An adjustment lever deceleration assembly for a steering column includes an adjustment lever rotatable between a locked position and an unlocked position. The adjustment lever deceleration assembly also includes a component positioned proximate the adjustment lever, the component rotating at a speed less than a rotational speed of the adjustment lever during adjustment between the locked position to the unlocked position. The adjustment lever deceleration assembly further includes an adjustment lever decelerator integrally formed with the adjustment lever, the adjustment lever decelerator positioned on the adjustment lever to contact the component during rotation of the adjustment lever toward the unlocked position, wherein the adjustment lever deflects and absorbs energy upon contact with the component. |
| US11420667B1 |
Cart pocket to prevent long items from passing through shopping cart
The cart pocket is a recess or pocket for installation at the front of a shopping cart or trolley. The cart pocket retains the end of one or more long objects, preventing the long objects from sliding through the wire frame of the shopping cart. The cart pocket is preferably built into the cart during initial construction but can be installed by removing a section of the wire or plastic frame of the cart, this section replaced with the cart pocket. This installation is ideal because the wire mesh is removed, simplifying access to the recess. Placing the recess outside the basket avoids interference with the contents of the basket. Alternatively, the cart pocket may be installed without removing a section of wire frame, the pocket placed either inside or outside of the basket of the cart. |
| US11420665B2 |
Height adjusting structure for casing, and accessory device for image forming apparatus
A height adjusting structure includes a coupling member configured to couple a caster to a casing, and the coupling member has a fixing part to which the caster is fixed, an extended part extended upward from the fixing part and penetrating through a bottom wall of the casing, and a meshing part formed at a portion within the casing on the extended part and having a plurality of engaging portions aligned at a predetermined pitch in a vertical direction. The height adjusting structure further includes a restraining member meshing with the meshing part formed on the extended part to restrain the extended part so that the extended part is unable to move vertically. |
| US11420663B2 |
System and method for providing railroad grade crossing status information to autonomous vehicles
A railroad communication system (100, 200) includes a wayside control device (130) in communication with one or more railroad crossing warning device(s) (140, 145) located at a railroad grade crossing (125), wherein the one or more railroad crossing warning device(s) (140, 145) are activated in response to a signal of the wayside control device (130). An autonomous motor vehicle (150) approaches the railroad grade crossing (125), wherein the wayside control device (130) is configured to communicate information in response to an activation of the one or more railroad crossing warning device(s) (140, 145), and wherein the autonomous motor vehicle (150) is configured to receive the information. |
| US11420662B2 |
Device and method for the safe management of vital communications in the railway environment
An apparatus and method for generating and verifying secure messages between vital equipment for controlling a railway network, wherein the apparatus includes control and/or processing components configured to carry out the following steps: a) generating a message body including information that may change the state of the railway network; b) generating a first pseudo-signature on the basis of the message body and a first cryptographic key; c) transmitting the first pseudo-signature to a second apparatus; d) receiving a second pseudo-signature from the second apparatus; e) generating a message signature on the basis of the second pseudo-signature and the first cryptographic key; f) generating a message by combining the message body and the message signature; g) sending the message to a recipient. |
| US11420661B2 |
Measurement system and method for producing an output measurement signal comprising at least one acceleration sensor
A measurement system for a vehicle includes an acceleration sensor. A first acceleration sensor of a sensor pair is fastened to a vehicle wheel and a second acceleration sensor of the sensor pair is fastened to the same vehicle wheel diametrically opposite with respect to the wheel axle. An evaluation device is connected to the two acceleration sensors of the sensor pair and generates an output measurement signal using the sensor signals from the two acceleration sensors. |
| US11420660B2 |
Luminous device for rail ways signals and the like, and management method thereof
The invention relates to a luminous device (5) and a method for managing said device (5), comprising LED lighting means (51), a dissipative electric load (52) adapted to increase an electric power dissipated by the device (5) when the LED lighting means (51) are emitting light, and current interrupting means (53) configured for dynamically interrupting the flow of current through said dissipative load (52) when the LED lighting means (51) are emitting light, so as to reduce the electric power dissipated by said device (5). |
| US11420659B2 |
Traffic control system and method for providing a preemption signal
A traffic control system (100) includes a railroad crossing control system (10) with a constant warning time device (40), a wheel sensing system (120) with a sensor (122) connected to a rail (20a, 20b) of a railroad track (20) at a predetermined position (P), and a communication network (140) interfacing with the railroad crossing control system (10) and the wheel sensing system (120) and adapted to transmit data. The wheel sensing system (120) provides speed values of a rail vehicle travelling on the railroad track (20), wherein the speed values are transmitted to the railroad crossing control system (10) via the communication network (140) for producing a preemption signal for the traffic signal control system (110). Further, a method for providing a preemption signal for a traffic signal control system (110) is described. |
| US11420651B2 |
Vehicle mode and passenger interface
A vehicle system including a vehicle component and a controller is provided. The controller may selectively activate the vehicle component and communicate with a mobile unit including an interface. The controller may be programmed to interact with the mobile unit upon detection by accessing vehicle sleep mode instructions preprogrammed by a user via the interface in which the controller activates the vehicle component according to an escalation sequence schedule to disengage a vehicle sleep mode. The system may further include a sensor in communication with the vehicle component and the controller. The controller may be further programed to activate the vehicle component according to the escalation sequence schedule based on receipt of a signal from a sensor indicating a passenger is asleep. |
| US11420646B2 |
Control system
A driving apparatus is controlled by using a driving command that is obtained by applying an accelerator operation amount to a relation between the accelerator operation amount and the driving command for the driving apparatus, and the relation is set by using a distribution of usage of the driving command by a driver such that a gradient that is a change in the driving command with a change in the accelerator operation amount in a high usage range including a value having a longest usage time among values of the driving command is less than the gradient in a range other than the high usage range. |
| US11420643B2 |
Device and method for calibrating vehicle assistance systems
A calibrating device for calibrating vehicle assistance systems is described. The device includes: at least one target pattern; at least one sensor, which is designed to detect the position and the orientation of a vehicle to be measured with respect to the calibrating device; and a positioning device, which is designed to position the at least one target pattern on the basis of the position of the vehicle to be measured, which is detected by the at least one sensor, in such a way that the at least one target pattern is situated in a specified orientation at a specified position with respect to the vehicle to be measured. |
| US11420641B2 |
System and method for determining the energy requirement of a vehicle for a journey
A system for determining an energy requirement of a vehicle for a journey. The system may comprise a predictor mechanism to predict, using an energy prediction algorithm, a vehicle energy requirement for the journey. The system comprises an updater mechanism configured to refine the energy prediction algorithm for the vehicle by determining for each of a number of historical journeys undertaken by the vehicle, an error between an actual vehicle energy usage for the historical journey and a predicted energy usage derived using the energy prediction algorithm for the historical journey. An aggregate error is calculated from the errors of the number of historical journeys. The updater is arranged to adjust the energy prediction algorithm to reduce the aggregate error. |
| US11420637B2 |
Apparatus and method for monitoring vehicle operation
Embodiments of the present invention provide a control system for a vehicle, the vehicle (800) being operable in an at least partly autonomous mode and a manual mode, the control system comprising input means (291, 292) for receiving a gaze signal (211) indicative of a direction of a gaze of an occupant of the vehicle (800), and a contact signal (212) indicative of physical contact between the occupant and a control of the vehicle, control means (250, 260, 270, 280, 290) configured to determine an estimate of the occupant's attention to a driving task in the at least partly autonomous mode in dependence on the gaze signal (211) and to determine when the occupant is at least partly obscured relative to the at least one imaging means (150, 220), wherein the control means (250, 260, 270, 280, 290) is configured to determine the estimate of the occupant's attention to the driving task in dependence on the contact signal when it is determined that the occupant is at least partly obscured. |
| US11420636B2 |
Information processing device, moving apparatus, method, and program
An alertness level that is the consciousness level of the driver of a vehicle is determined, and the timing of a manual driving return request notification is controlled in accordance with the alertness level. A data processing unit determines the alertness level of the driver of the vehicle, and records evaluation data. The data processing unit acquires observation information about the driver, determines the alertness level of the driver, and evaluates and records the return rate at each time. The vehicle is a vehicle capable of switching between automatic driving and manual driving, and the data processing unit controls the timing of a manual driving return request notification for the driver's return from automatic driving to manual driving, in accordance with the alertness level of the driver. The observation information to be acquired by the data processing unit includes observation information about the driver both before and after the driver gets in the vehicle. For example, passive monitoring, information about the driver's response to a notification, and the like are observed. |
| US11420635B2 |
Device and method for controlling traveling of vehicle
A device for controlling traveling of a vehicle is provided. The device includes a sensor that obtains vehicle traveling information, a navigation that obtains vehicle position information, and a controller that determines whether the vehicle has entered a building based on the vehicle traveling information and the vehicle position information. The controller calculates a traveling control amount based on the determination result. Accordingly, the device actively adjusts a vehicle height even when the vehicle enters the building and travels on a slope in the building preventing damage to a lower portion of the vehicle. |
| US11420633B2 |
Assisting the driving of an automotive vehicle when approaching a speed breaker
A driving assistance method for a motor vehicle (1) when approaching a speed bump comprises, according to the invention: detecting and tracking at least one other moving vehicle (41) in front of the motor vehicle (1) based on processing images captured by a camera (10) on board the motor vehicle (1); establishing a temporal profile of the estimated distance between the motor vehicle (1) and the at least one detected and followed other moving vehicle (41); detecting an anomaly area in the temporal profile; and estimating a distance dbump between the motor vehicle (1) and a speed bump (3) on the basis of the estimated distance between the motor vehicle (1) and the at least one other vehicle (41) at a time separate from the times corresponding to the detected anomaly area. |
| US11420630B2 |
Trajectory modifications based on a collision zone
The described techniques relate to modifying a trajectory of a vehicle, such as an autonomous vehicle, based on an overlap area associated with an object in the environment. In examples, map data may be used, in part, to generate an initial trajectory for an autonomous vehicle to follow through an environment. In some cases, a yield trajectory may be generated based on detection of the object, and the autonomous vehicle may evaluate a cost function to determine whether to execute the yield or follow the initial trajectory. In a similar manner, the autonomous vehicle may determine a merge location of two lanes of a junction, and use the merge location to update extents of an overlap area to prevent the autonomous vehicle from blocking the junction and/or provide sufficient space to yield to the oncoming vehicle while merging. |
| US11420627B2 |
Driving assistance device
A driving assistance device is configured to perform deceleration control in such a way that a vehicle stops at a target position determined by a deceleration target ahead of the vehicle. The driving assistance device is configured to calculate a predicted vehicle speed of the vehicle at the target position when the deceleration control is performed, based on the current vehicle speed of the vehicle, the distance to the target position, and the deceleration that varies depending on the type of the deceleration target. When the predicted vehicle speed is higher than a predetermined value, the driving assistance device is configured not to perform the deceleration control or to reduce the deceleration in the deceleration control. |
| US11420626B2 |
Method for operating a vehicle, and control unit
A method for operating a vehicle. When an autonomous cruise control is in the activated state, a switch is made to an accelerator-pedal-controlled distance controller in response to an acceleration command indicated by an override of an accelerator pedal of the vehicle. |
| US11420624B2 |
Vehicle control apparatus and vehicle control method
When there is a possibility of collision between a host vehicle and objects positioned in a detection region in front of the host vehicle, an ECU implements collision avoidance control for preventing the host vehicle from colliding with an object. The ECU detects the objects positioned in the detection region and judges whether, among the detected objects, there is an object that the host vehicle has overtaken and that is capable of moving within a prescribed range in the vehicle width direction of the host vehicle. If it is judged that the host vehicle is turning to the left or to the right after it has been judged that the host vehicle has overtaken an object, the actuation timing of the collision avoidance control is advanced. |
| US11420618B2 |
Driving force control method and system for vehicle
A driving force control device 1 for a vehicle V comprises: a D-μ map M1 defining a linear correlation between a driving stiffness D and a maximum road surface μ; a slip ratio calculation circuit 21 for calculating a slip ratio S of one of a pair of front road wheels 10L, 10R; a DS calculation circuit 22 for calculating the driving stiffness D corresponding to a value the slip ratio S calculated by the slip ratio calculation circuit 21; a maximum road surface μ calculation circuit 23 for assigning a value of the driving stiffness D calculated by the DS calculation circuit 22 to the D-μ map M1 to calculate the maximum road surface μ; and a driving force distribution circuit 24 for controlling a driving force, using a value of the maximum road surface μ calculated by the maximum road surface μ calculation circuit 23. |
| US11420614B2 |
Anti-jerk engagement
A control device for a vehicle having a plurality of torque sources provided on an axle includes a plurality of control outputs configured to allow control signals to be output to individual torque sources of the plurality of torque sources and in order to influence the torque generated by the torque sources. The control device is configured to perform an anti-jerk function configured, in dependence on a rotational speed of at least one of the torque sources, to determine a countertorque value for an engagement, in order to reduce oscillations in a longitudinal movement of the vehicle. The control device is configured to carry out a splitting function configured to split the countertorque value into at least two partial countertorque values. The control device is also configured to output the control signal at different control outputs in dependence on the respectively assigned partial countertorque values. |
| US11420609B2 |
System and method for controlling engine stop-start events
Systems and methods are provided for controlling a transmission. An engine stop-start event may be allowed or denied based on one or more characteristics of the vehicle including the transmission. |
| US11420608B2 |
Vehicle electricity storage device
A vehicle electricity storage device includes a capacitor unit for supplying stored electric power to an electronically controlled system, and a microcomputer including a memory. The memory stores a plurality of thresholds (internal resistance limit values) different from each other. Each of the plurality of thresholds is to be compared with an electrical characteristic value (internal resistance value) related to the capacitor unit for determining a deterioration state of the capacitor unit. The each of the plurality of thresholds is stored in association with an identification ID for identifying the electronically controlled system. The microcomputer acquires the identification ID from the electronically controlled system. And the microcomputer selects, from the plurality of thresholds, a threshold associated with the identification ID acquired. Then the microcomputer determines the deterioration state of the capacitor unit by using the electrical characteristic value and the threshold selected. |
| US11420598B2 |
Windscreen wiper arm, particularly for automobiles
A windscreen wiper arm comprising a wiper arm member having a substantially U-shaped cross-section arranged to be pivotally connected to a mounting head mounted on a drive shaft, and a wiper rod having a first end rigidly connected to and extending inside said wiper arm member and a second end arranged to be connected to an elongated wiper blade to be placed in abutment with a windscreen to be wiped. The windscreen wiper arm includes a nozzle for spraying a washing liquid onto said windscreen to be wiped, where said nozzle is detachably connected to said wiper rod inside the U-shaped cross-section of the wiper arm member. |
| US11420590B2 |
Vehicular removable battery and antitheft system for vehicular removable battery
A vehicular removable battery removably mountable in an electric vehicle includes a time acquirer configured to acquire a current time, a time period storage storing a time period in which electric power is supplied, and an electric power supply controller configured to control the supply of the electric power stored in an electric power storage to the electric vehicle. After the electric power supply controller detects that an activation instruction of the electric vehicle has been issued, the electric power supply controller is configured to enable the supply of the stored electric power to the electric vehicle in a case where the acquired current time is included in the stored time period. The electric power supply controller is configured to prohibit the supply of the electric power to the electric vehicle in a case where the acquired current time is not included in the stored time period. |
| US11420587B2 |
Anchor pretensioner module for seat belt
An anchor pretensioner module for a seat belt includes: an anchor which is disposed at a side of a seat cushion, and to which a tongue of the seat belt is fastened, a base which is provided at a lower side of the anchor, the base having a first operating part, which generates an explosive pressure, provided at a rear of the base, and a second operating part, which generates the explosive pressure, provided at a front of the base, a first wire which is connected to the base and the anchor, and allows the anchor to be moved downward when the first operating part is operated, and a second wire which is provided on the base, and moves the first wire while being inserted into the base when the second operating part is operated to allow the anchor to be moved forward while moving downward, so that a relative location of the anchor is moved when a collision occurs to restrain a passenger's body. |
| US11420586B2 |
Tortuous path filter for airbag inflator
An airbag assembly may include an airbag and an inflator that provides inflation gas to inflate the airbag. A filter module may be positioned such that inflation gas exiting the inflator must first pass through the filter module. The filter module may be formed of a sheet of metal that is wrapped into a generally spiraling tubular shape. The filter module may have an inner layer, an intermediate layer, and an outer layer. The intermediate layer generally encircles the inner layer, and the outer layer generally encircles the inner layer and the intermediate layer in a spiraling fashion. The inner layer, the intermediate layer, and the outer layer each may have a pattern of holes and dimples that are separate from and/or displaced from each other. The dimples may protrude toward an adjacent layer to maintain spacing to enable relatively unrestricted gas flow from the holes of the inner layer through unaligned holes of the intermediate layer and the outer layer. The resulting tortuous gas flow path may help to slow, cool, and/or purify the gas before it exits the inflator. |
| US11420581B2 |
Vehicle device operation apparatus
This vehicle device operation apparatus is provided with: a deforming body which is configured so as to be attached to a vehicle seat and in which a fluid is sealed; and a control device. The control device is configured so as to detect the inner pressure of the deforming body, detect an adjusting operation which is an occupant's operation for adjusting the operated state of a vehicle device on the basis of a change in inner pressure of the deforming body caused by pressing of the deforming body through the body movement of an occupant seated on the seat, and execute adjustment control for adjusting the operated state of the vehicle device in response to the detection of the adjusting operation. |
| US11420580B2 |
Instrument panel and method for manufacturing instrument panel
Provided are: an instrument panel capable of stably deploying a deployment part; and a method for manufacturing the instrument panel. An instrument panel is provided with: a base part; and a deployment part which is surrounded by the base part, faces an air bag, and includes a tear line, wherein a slit structure including a plurality of slits arranged so as to surround the tear line is formed in the deployment part. |
| US11420579B2 |
System and method to automatically set the height of the torso section of a seat belt
A vehicle, system and a computer-implemented method for setting a height of a seat belt in a vehicle. The system includes a computer vision module, a motor and a controller. The computer vision module determines a seatbelt-neck distance (SND) and a seatbelt-shoulder distance (SSD) for an occupant of the vehicle. The motor adjusts the height of the seat belt. The controller control the motor to set the height of the seat belt based on the SND and the SSD. |
| US11420577B2 |
Radar transparent decorative plate for the front grille of a motor vehicle
Radar transparent decorative plate for the front grille of a motor vehicle, of the monobloc type with a first layer of PMMA transparent to light, like a smooth lens with decorative elements in relief on the back, and an overmoulded second layer of opaque ABS-PC or opaque ABS that compensates for the height thereof simultaneously realizing a support with integrated fastening elements and a masking background. On the back is a particular decorative treatment having an ultra-thin metallization layer with a thickness of less than 0.05 micrometres, on which a shadowing layer with an anti-transparency effect is superimposed. Embodiment variants are provided in which the decorative elements have a three-dimensional appearance obtained from a mould by means of cavities in the head or with a shading optical effect. |
| US11420575B2 |
Power supply and a method for supplying power
A power supply for an energy management and monitoring unit includes a line arrangement with multiple lines representing inputs or outputs, each of which has at least one power line for supplying power. A merging unit combines the power lines of the line arrangement to a total voltage, and a splitting unit is configured to split the total voltage into at least two redundant voltages provided for the energy management and monitoring unit. |
| US11420574B2 |
Steering switch
A steering switch is provided on a spoke of a steering wheel for steering a vehicle, and includes a main switch pressed to input an ON/OFF operation of a drive assistance system installed in the vehicle, and an approval switch pressed to input an approval of a lane change executed by the drive assistance system. The approval switch is arranged adjacent to the upper side of the main switch. |
| US11420573B2 |
Wire harness routing apparatus
A wire harness routing apparatus includes: a wire harness arranged between a base portion provided in a vehicle and a seat that is provided so as to be able to rotate with respect to the base portion; a case that can rotate together with the seat while accommodating the wire harness; and a base-side fixing portion that fixes, to the base portion, an end portion of the wire harness pulled out toward the base portion from the case, and that can rotate relative to the case accompanying rotation of the seat. The case includes a first accommodation portion that is arranged inside of a range of a rotational path on which the base-side fixing portion rotates relative to the case, and a second accommodation portion that is provided bulging from a portion that is different from the range of the rotational path on which the base-side fixing portion rotates. |
| US11420570B2 |
Wireless camera mounting system
A camera mounting system and a method for processing images are disclosed. The system includes an external component configured to capture thermal images, and an internal component configured to receive the thermal images. The thermal images are wirelessly transmitted by the external component, the external component is coupled to the internal component via a glass, and the internal component is further configured to wirelessly power the external component. |
| US11420569B2 |
Flexible light blocking element
A light blocking element (5) for an imaging system (1) for a motor vehicle including a bottom section (6), a left wall section and a right wall section (8), the wall sections (8) extending from an opening (12) for reception of a camera lens (4) between the wall sections (8), the wall sections (8) being attached to the bottom section (6) at a first end (9), the wall sections' second end (13) being adapted to be attached to a motor vehicle windshield (2). The wall sections (8) being elastically deformable. |
| US11420565B2 |
Cargo divider assembly for a vehicle
A cargo divider assembly for a cargo area of a vehicle includes a storage compartment defined within the cargo area, first and second receiving slots defined within the storage compartment, and a lid. The lid is operable between a cover position, wherein the lid covers the storage compartment, a first divider position, wherein the lid is received within the first receiving slot and extends a first distance into the storage compartment, and a second divider position, wherein the lid is received within the second receiving slot and extends a second distance into the storage compartment that is greater than the first distance. |
| US11420562B2 |
Backlight unit
A backlight unit 10 for an outside mirror of a vehicle may comprise: a light source unit 30 including at least one light source 31 disposed therein; a light processing unit 40 having at least one light passage 41 through which light emitted from the light source 31 passes while being diffused, and a reflective surface 42 for reflecting the light having passed through the light passage 41; and a photorefractive means 60 which is disposed at a light exit of the light processing unit and refracts light emitted from the light exit of the light processing unit to be oriented toward a driver's seat. |
| US11420552B2 |
Vehicle light with dual projection film
A vehicle light module, a headlight assembly, and a method for communicating information at a panel having transparent and opaque states; a projector device projects visual representations toward the panel where visual representations are displayed on the panel when in an opaque state and through the panel when in a transparent state. |
| US11420550B2 |
Adjusting system for pivoting at least one optically relevant component of a vehicle headlight about a first and a second axis
The invention relates to an adjusting system (1) for pivoting at least one optically relevant component (2) of a vehicle headlight about a first and a second axis (y, z), the system comprising a first retaining element (3) for holding the optically relevant component (2), a second retaining element (4) for displaceably holding the first retaining element (3) on the second retaining element (4), a carrying frame (5) for displaceably holding the second retaining element (4) on the carrying frame (5), and a first adjusting device (6) acting on the first retaining element (3) for displacing the first retaining element (3) relative to the second retaining element (4), and a second adjusting device (7) acting on the second retaining element (4) for displacing the second retaining element (4) relative to the carrying frame (5). |
| US11420546B2 |
Seat assembly having compression limiter with wave portion
A seat assembly includes a frame, a seating base layer arranged on the frame and a compression limiter layer arranged on the seating base layer. The compression limiter layer includes a coil portion and a wave portion having a curved profile. The wave portion includes a plurality of wave elements and one or more ribs connected between the wave elements. The seat assembly further includes a load distribution layer connected to the compression limiter layer and an adjustment module movable between a rear position and a forward position. The adjustment module is configured to move the wave portion between a retracted position and an extended position. |
| US11420543B2 |
Seat track mechanism for vehicle
The present disclosure provides a seat track mechanism installed beneath a vehicle seat in order to move the vehicle seat in the forward and backward directions. A monotrack mechanism, to which a monopost structure and a single rail structure are applied, is installed at the bottom of the seat. The seat track mechanism includes a structure for hook-engaging lower and upper rails constituting the mono track mechanism by hook guides, thereby being capable of securing sufficient strength upon head-on or rear-end collision. The present disclosure also provides a seat track mechanism for a vehicle including a locking mechanism capable of enhancing stability of a passenger through structural reinforcement given at the bottom of the vehicle when it is necessary to ensure safety of the passenger in a situation such as collision or sudden stop or the like. |
| US11420540B2 |
Child safety seat and related spin lock mechanism
A child safety seat includes a base, a seat body and a spin lock mechanism. The seat body is movably disposed on the base and switchable relative to the base between a forward facing position and a rearward facing position. The spin lock mechanism is for allowing and restraining switching movement of the seat body relative to the base and includes a pivoting component and a locking component. The pivoting component is pivotally connected to one of the base and the seat body. The locking component is movably connected to the pivoting component for engaging with and disengaging from the other of the base and the seat body. The locking component can be driven by a pivoting movement of the pivoting component to disengage from the other of the base and the seat body to allow the switching movement of the seat body relative to the base. |
| US11420538B2 |
Seat elevating device
Disclosed is a seat elevating device including a support unit, a driving unit, and an elevating unit. The support unit is structured such that a first end is coupled to a body of a vehicle and a second end extends upward from the first end and is connected to a first end and a second end of a bar. The driving unit is coupled to an inner side surface of the support unit and equipped with a drive shaft on a side surface thereof. The elevating unit is connected to the drive shaft via a gear unit and is provided with a groove to receive the bar so that the bar slides along the groove. The elevating unit is slidable because it is engaged with the gear unit connected to the drive shaft via a rack gear that extends in parallel with a sliding movement direction of the elevating unit. |
| US11420537B2 |
Conveyance seat
A vehicle seat includes a seat cushion provided with a seat cushion frame, a front link configured to adjust a height of the seat cushion with respect to a base that is a slide rail or a vehicle body floor, and a front load detection sensor attached to an upper rail and configured to detect a load applied to the vehicle seat. The seat cushion frame includes a pair of side frames separated from each other in a seat width direction, the front link includes a first rotation shaft configured to be rotatable with respect to the seat cushion frame and a second rotation shaft configured to be rotatable with respect to the base, and the front load detection sensor is arranged at a position different from the second rotation shaft in a front to back direction of the seat. |
| US11420536B2 |
Vehicle seat gearbox bracket
The vehicle seat may include a fixed portion, a moveable portion, a gearbox, and a reinforcement bracket. The gearbox may be fixed to either the fixed portion or the moveable portion and may be configured to move the moveable portion with respect to the fixed portion. The reinforcement bracket may include a first end portion, a second end portion, and a medial portion that may extend therebetween. The first end portion may define a first U-shaped opening, the second end portion may form a second U-shaped opening, and the medial portion may form a third U-shaped opening that may receive the gearbox. |
| US11420535B2 |
Battery temperature raising device for hybrid vehicle
The disclosure is a battery temperature raising device for hybrid vehicle that raises the temperature of a battery. In an engine travelling mode, when an engine water temperature is higher than a specified cooling water temperature, a first battery circuit is connected to a main circuit and the temperature of the battery is raised by cooling water in the main circuit (first temperature raising control). In a motor travelling mode, when a motor generator temperature is higher than a battery temperature, the first battery circuit and a heat exchanger flow path are connected to the main circuit, and thereby a closed circuit through which cooling water circulates without passing through an engine is formed, and the temperature of the battery is raised by the cooling water that is raised in temperature by heat exchange with a refrigerant in a heat exchanger (second temperature raising control). |
| US11420530B2 |
System and methods for a charging network of mobile power transmitters
A decentralized charging network of mobile power transmitters comprises a server, power receivers, and a fleet of deployable mobile power transmitters comprising a control system, a power source system having a charge measuring device for monitoring the charge transfer, a charging system configured to transfer charge from the power source system to the power receiver, and a communication system for communication between a power receiver, a server, and the control system. A charging request is received and processed by a server from a power receiver or an operator preparing to charge a power receiver. A qualified mobile power transmitter is identified and instructed to arrive at a location and to charge a power receiver according to charging instructions prepared by the server. The charging is monitored and, upon completion, the mobile power transmitter deactivates the charging session and informs the server. |
| US11420525B2 |
Tractor trailer with included battery charging
A vehicle includes a charging dock carried by the vehicle, a safety arm carried by the vehicle, a battery carried by the safety arm, and a light source on the safety arm that is in electrical communication with the battery. The battery is in electrical communication with the charging dock and the charging dock charges the battery. |
| US11420523B2 |
Enhanced electric drive vehicle operation via pulse width modulation (PWM) type and frequency control
Presented are high-voltage electrical systems with optimized pulse width modulation (PWM) control, methods for making/using such systems, and vehicles with enhanced electric drive capabilities via PWM type and frequency control. A method of operating an electrical system includes an electronic controller determining a PWM region layout with multiple PWM regions arranged in a torque-speed curve calibrated to an electric motor and power inverter. The controller selects one of the PWM regions based on a speed and torque of the motor, and selects a PWM type based on this selected PWM region. The controller selects a PWM switching frequency style based on the selected PWM region, and selects a PWM switching frequency based on the selected PWM region, switching frequency style, and PWM type. The controller commands a power inverter to regulate transfer of electrical power between a rechargeable battery and the motor based on the PWM type and switching frequency. |
| US11420517B2 |
Brake pedal sleeve with throttle protection function and installation method for facilitating installation
A brake pedal sleeve with a throttle protection function and for facilitating installation of the throttle protection, including a main bracket plate, an auxiliary baffle plate, a protection rod, an anti-slip rubber pad, a brake pedal and an adjusting screw; wherein a supporting head, a square hook strip, a main baffle plate and the anti-slip rubber pad are provided on the main bracket plate; the protection rod is provided with a connecting rod, a limiting ring and a limiting screw, one end of the protection rod supporting shaft is provided with a circular head, and the protection rod supporting shaft passes through a washer, a protection rod through hole, a supporting head through hole and an inner hole of the spring ring, and the main bracket plate and the protection rod are combined together; the installation of the present disclosure is more convenient, quick and more stable. |
| US11420509B2 |
Vehicle lower structure
A floor anchor for supporting a webbing waist portion of a seat belt mechanism is supported by a seat rail that is a frame member of a seat cushion. The seat rail is supported by a rear floor panel through a fastening panel that is a holding member. An end portion of a battery pack is also supported by the floor panel through the fastening panel. |
| US11420505B1 |
Door and roof configurations for vehicles
A vehicle includes a vehicle body, a first panel assembly that is movable between a closed position and an open position with respect to a first opening of the vehicle body, a second panel assembly that is movable between a closed position and an open position with respect to a second opening of the vehicle body, a front seat that faces rearward and is accessible from the first opening and the second opening, and a rear seat that faces forward and is accessible from the first opening and the second opening. |
| US11420504B2 |
Coupling structure of touch sensor
A part of a touch sensor, which couples to a curve of a flange, includes a raising member. The curve of the flange is on a belt line of a sliding door. The raising member rises outwardly toward an exterior of the automobile from an inner-cabin side wall of the touch sensor. A space is formed between the raising member and an outer-cabin side wall for the flange to be inserted into the space. The raising member includes a plurality of blocks. The plurality of blocks exist along an upper and lower direction of the automobile body. |
| US11420503B2 |
Sliding-door drive device
A sliding-door drive device includes: a motor; a speed reducing mechanism reducing rotation of the motor; opening and closing cables having respective one ends secured to a sliding door of a vehicle; an opening drum, having the opening cable wound therearound, to be rotated by the motor through the speed reducing mechanism; and a closing drum, having the closing cable wound therearound, to be rotated by the motor through the speed reducing mechanism. Further, rotation axes of the motor, the opening drum, and the closing drum are parallel, and the opening drum and the closing drum are arranged parallel in radial directions thereof. |
| US11420502B1 |
Door structure
A door structure includes a safety device arranged on a surface of the door structure facing a pillar of a vehicle body, wherein the safety device includes: a case member having an opening which opens to the pillar; a slide pin configured to slide from an initial position to a protruded position, in a direction from the case member toward the pillar; and a stopper configured to fix the slide pin in the protruded position when the slide pin has slid to the protruded position. |
| US11420500B2 |
Variable air vent
A variable air vent is provided. The air vent includes a housing that is mounted on a vehicle and has an open center. A ball housing is coupled to the housing and has an inner side surface that is formed in a curved surface. A ball configured has front and rear surfaces opened and a side surface that is inserted into the ball housing in a curved surface form corresponding to the ball housing. A first knob and a second knob are vertically disposed on the front and rear surfaces of the ball and a plurality of discharge range adjusting wings have a first rotating shaft that is integrally formed at one end of a flat plate. A first side of the first rotating shaft is inserted into the ball and a second side thereof includes a first wing gear inserted into the second knob. |
| US11420492B2 |
Actuator device for an adjustable roll stabilizer of a motor vehicle
An actuator device (1) for an adjustable roll stabilizer (2) of a motor vehicle, with a housing (4) that extends in the direction of a rotational axis (3) and an actuator (5) arranged in the housing. The actuator device (1) can be operated to twist two stabilizer sections (7a, 7b) relative to one another about the rotational axis (3) and the two stabilizer sections (7a, 7b) are attached to opposite ends (6a, 6b) of the actuator device (1). An engagement contour (8) is formed on the housing (4), which is suitable for immobilizing the housing during the application of torque (M1) to the housing (4) in a direction around the rotational axis (3). |
| US11420491B2 |
Plant scanning vehicle
Plant scanning vehicles (10) including, but not limited to, plant scanning vehicles for use in field-based phenotyping. There is a central body (16); three or more legs (15) extending from the central body (16) to support a wheel (13) on each leg (15); wherein the three or more legs (15) are mounted to the central body (16) rotatably about a respective vertical axis (95) to allow adjustment of a track width W of the vehicle by rotating the legs wherein the legs are mechanically coupled to transmit rotation between the legs about their respective vertical axes and the central body (16) or the three or more legs (13) are configured to support a sensor (47) to scan plants. |
| US11420485B2 |
Method for detecting a leak in a tire of a stationary vehicle
A method of detecting a leak from a tire of a vehicle, the tire including a member for measuring the pressure and the temperature having a driving operating mode and a stationary operating mode, comprising determining that the vehicle is stationary; and then launching the stationary operating mode to detect when the vehicle is stationary the presence or the absence of a leak of inflating gas from the tire. |
| US11420484B2 |
Pneumatic tire
A pneumatic tire includes a plurality of protrusion portions extending along a tire side surface of a tire side portion in a direction that intersects a tire circumferential direction and a tire radial direction. Each of the plurality of protrusion portions includes an intermediate portion and an end portion. The intermediate portion in an extension direction has a highest position of a projection height from the tire side surface. The end portion is provided on either end of the intermediate portion in the extension direction, and has a lowest position of the projection height from the tire side surface. The highest position of the projection height of the intermediate portion is disposed in a range of 20% of a tire cross-sectional height on an inner side and an outer side in the tire radial direction from a tire maximum width position. |
| US11420483B2 |
Tire noise reduction device
A tire noise reduction apparatus may include a housing mounted on an external circumferential surface of a wheel rim on which a tire is mounted, the housing having an internal space and being open at one side in a circumferential direction of the wheel rim, wherein the housing includes a neck at an opposite side which is opposite to the open one side; and a movable member inserted into the internal space of the housing through the open one side of the housing and having an internal space in fluidical communication with the internal space of the housing, the movable member being mounted to the housing to be movable in a direction in which the movable member is inserted into the internal space of the housing and in a direction in which the movable member is withdrawn out of the housing. |
| US11420481B2 |
Pneumatic tire
A pneumatic tire includes a decorative portion on a tire side portion that is an outer surface of a sidewall portion. The decorative portion includes a plurality of ridges that extend along the tire side portion and are arranged side by side in the tire circumferential direction. The plurality of ridges include a common form of an inclination angle in the tire circumferential direction with respect to the tire radial direction and an interval between a pair of the plurality of ridges adjacent. The plurality of ridges constitute a ridge group. Three or more ridge groups are provided and the plurality of ridges of the different ridge groups are arranged intersecting one another. Accordingly, the pneumatic tire can reduce poor appearance of the sidewall portion. |
| US11420480B2 |
Tyre
A tyre includes a tread portion being provided with two circumferential grooves extending in a tyre circumferential direction to form a crown land portion therebetween. The crown land portion is provided with two or more crown grooves extending inwardly of the crown land portion from the respective circumferential grooves. Each crown groove includes wide-width regions and narrow-width regions having a groove width smaller than that of the wide-width regions, and the wide-width regions and the narrow-width regions are alternated. |
| US11420477B2 |
Motorcycles tyre
Motorcycles tyre, comprising: a radial carcass structure (2); a belt structure (6) applied in radially outer position with respect to the radial carcass structure (2); a tread band (8) applied in radially outer position with respect to the belt structure (6). The tyre (1) has a curvature ratio (f/C) greater than or equal to about 0.25. The tread band (8) comprises: a plurality of blocks (14) mutually spaced so as to define a tread pattern with a void/solid ratio (1−Sb/St) comprised between about 25% and about 50%; transverse grooves (11) placed in succession along the circumferential extension of the tyre (1) and each substantially extending over the entire axial width of the tread band (8). Each transverse groove (11) substantially extends along an axial direction. Two successive transverse grooves (11) circumferentially delimit an assembly (12) of blocks (14) placed in succession over the entire axial width of the tread band (8). Circumferential grooves (13) delimit the blocks (14) of an assembly (12). A ratio between a circumferential length (LI) of the blocks (14) and a width (L2) of the transverse grooves (11) is equal to or greater than about 2. |
| US11420476B2 |
Tire
The tire whose mounting position relative to a vehicle is specified, comprises a tread portion having a first tread edge and a second tread edge, and provided with three main grooves and four land portions. The main grooves include a first shoulder main groove, a second shoulder main groove, and a crown main groove. The land portions include a first middle land portion and a second middle land portion. The first middle land portion is disposed on the tire equator. The first middle land portion is provided with first transverse narrow grooves. The first transverse narrow groove comprises a first deep portion, a second deep portion and a first shallow portion therebetween to improve steering stability and ride comfort. |
| US11420469B2 |
Wheel hub and bearing assembly packaging
A packaging system having an outboard guard and an outboard retainer cap. The outboard guard includes an outboard guard opening having a hole through the planform of the outboard guard, an engagement portion having an annular surface radially surrounding the outboard guard opening, an outboard bearing protector portion having an annular surface radially surrounding the engagement portion of the outboard guard, and an outer rim having an annular surface radially surrounding the outboard bearing protector portion. The outboard retainer cap is configured to be removably affixed to the outboard guard and includes an outboard alignment protrusion having a circular surface, an engagement portion having an annular surface radially surrounding the outboard alignment protrusion, and a retaining flange having an annular surface radially surrounding the engagement portion of the outboard retainer cap. |
| US11420460B2 |
Printing device having receiving portion for selectively receiving one of first cassette and second cassette
A printing device includes: a housing; a print head extending in a first direction; a cassette receiving portion; and a movable cover. The cassette receiving portion is open in a second direction orthogonal to the first direction. The cassette receiving portion can selectively receive a first cassette or a second cassette whose size is greater than that of the first cassette. The movable cover is movable between a closed position and an open position for covering and exposing the cassette receiving portion in the second direction. The cassette receiving portion provides: a first cassette receiving portion for receiving the first cassette with the movable cover at the closed position; and a second cassette receiving portion for receiving the second cassette with the movable cover at the open position. A portion of the second cassette receiving portion is overlapped with the movable cover at the closed position in the first direction. |
| US11420456B2 |
Movement mechanism and printing apparatus
A movement mechanism for a movable body including a motor including a rotation shaft, a supporting member that supports the motor, an attachment member fixed to a base body portion and to which the supporting member is attached, a driving pulley coupled to the rotation shaft, a driven pulley attached to the base body portion, an endless belt stretched between the driving pulley and the driven pulley, and the movable body attached to the endless belt, in which the supporting member is configured to be pivotally movable about a position serving as a pivotal axis such that a distance between the driving pulley and the driven pulley shortens, the position being at a side of the driven pulley from the driving pulley in a stretching direction in which the endless belt is stretched between the driving pulley and the driven pulley. |
| US11420455B2 |
Conveying device and image forming apparatus including conveying device
A conveying device includes a plurality of conveyance passages, a plurality of conveyors, a conveyance passage guide, a conveyance sensor, a conveyance availability detector, and circuitry. The conveyance passages are disposed in parallel to each other. Each conveyors is disposed in corresponding one of the conveyance passages. The circuitry is configured to: set a set retention time for which a conveyance object is to be retained in available one of the conveyance passages; control one of the conveyors to convey and stop conveying the conveyance object guided by the conveyance passage guide; measure a retention time of the conveyance object conveyed in the available one of the conveyance passages; and cause the one of the conveyors to eject the conveyance object from the available one of the conveyance passages in a case in which the retention time of the conveyance object is longer than the set retention time. |
| US11420454B2 |
Recording apparatus
A control section of a recording apparatus is configured to execute control of overlapping transportation in which a preceding medium and a following medium are transported in a state in which a rear end region of the preceding medium and a leading end region of the following medium overlap at least in a partial section in an upper transport route, and determines an overlapping dimension Lk that is a dimension, by which the rear end region of the preceding medium and the leading end region of the following medium overlap, in accordance with a route dimension Ld from a third feed roller pair to an edge of an introducing port in a second direction, when executing the control of the overlapping transportation. |
| US11420452B2 |
Half cutter and tape printing apparatus
A half cutter includes a blade, a blade holder to which the blade is fixed, and a blade receiving member which the blade approaches to or departs from. The blade holder has a pressure receiving portion that receives a pressing force which presses the blade holder against the blade receiving member, and a transmission section that transmits the pressing force received by the pressure receiving portion to both end portions of the blade in an extending direction of a blade edge of the blade. |
| US11420450B2 |
Printing apparatus
A printing apparatus includes a printing device to print, on a sheet, a detection mark for acquiring an amount of deviation of an image, a detection device to read a position of the detection mark and acquire the amount of deviation of the position of the detection mark, and control circuitry to perform correction according to the amount of deviation. The circuitry prints the detection marks on both faces of the sheet in duplex printing, reads the detection marks on both faces with the detection device, calculates a first correction value from the position of the detection mark on a first face on which printing is performed first, calculates a second correction value from the position of the detection mark on a second face on which printing is performed later, and calculates a third correction value from the positions of the detection marks on the first and second faces. |
| US11420447B2 |
Liquid discharging head, liquid discharging unit, and device for discharging liquid
A liquid discharging head includes a nozzle plate having a plurality of nozzles from which liquid is discharged; a plurality of individual liquid chambers that are communicably connected to the plurality of nozzles, respectively; a common liquid chamber that supplies liquid to the plurality of individual liquid chambers; and a circulation common liquid chamber that leads to a plurality of circulation channels. A part of the common liquid chamber overlaps the circulation common liquid chamber from a direction in which liquid is discharged from the nozzles, and another part of the common liquid chamber overlaps the circulation common liquid chamber from a direction orthogonal to both the direction in which liquid is discharged from the nozzles and a direction in which the nozzles are aligned. |
| US11420443B2 |
Image recording apparatus
An image recording apparatus includes a cartridge installing unit for detachably installing a plurality of ink cartridges. The cartridge installing unit includes: a base having a placing surface and aligning the plurality of ink cartridges in a first direction on the placing surface; a moving force applying unit moving an ink cartridge of the plurality of ink cartridges from an installation position to a removal position separated from the installation position in a movement direction including a component of the first direction; and a regulating unit regulating the movement of the ink cartridge from the installation position to the removal position. The moving force applying unit moves the ink cartridge from the installation position to the removal position in a case that the ink cartridge is released from the regulation by the regulating unit. |
| US11420441B2 |
Printing apparatus and printing method
A printing apparatus includes: power supply circuits including at least first and second power supply circuits; a head including nozzles, the nozzles forming groups arranged in a first direction, each of the groups including nozzle arrays arranged in the first direction, each of the nozzle arrays extending in a second direction intersecting with the first direction, and each of the nozzles being associated with any of the power supply circuits; and a memory storing information. The information indicates correspondence relationships between the nozzles and the power supply circuits, between the nozzles and the groups, and between the nozzles and the nozzle arrays. Printing is performed by driving the head based on the information. The groups include a first group and a second group adjacent to each other in the first direction. The first group includes a first nozzle array adjacent to the second group in the first direction. |
| US11420439B2 |
Liquid discharge head
There is provided a liquid discharge head, including: a plurality of inlet parts provided corresponding to a plurality of kinds of liquids; a plurality of pressure chambers in which discharge pressure is applied to the liquids; a plurality of individual outlet parts through which the liquids are supplied to the plurality of pressure chambers; and a manifold which communicates with the plurality of inlet parts, and through which the liquids from the plurality of inlet parts are supplied to the plurality of individual outlet parts. The manifold includes: a plurality of upstream-side portions in each of which a channel corresponding to one of the plurality of inlet parts is defined, and a downstream-side portion which communicates with the plurality of upstream-side portions, and in which a channel communicating with the plurality of individual outlet parts is defined. |
| US11420436B2 |
Device for attaching a doctor blade on a doctor blade chamber and doctor blade chamber thus equipped
A device (10) for fastening a doctor blade (3) to a doctor blade (1) chamber body (2) comprising: at least one clamping flange (11) configured to press the doctor blade (3) onto the doctor blade (1) chamber body (2), at least a first fastener (20), and at least one second fastener (30), wherein the first fastener (20) comprises at least a first retaining section (21) having an upper end (21a) and a lower end (21b), a second section (22) different from the first retaining section (21), and wherein the second fastener (30) comprises at least a first portion (31) having at least one retaining element (34a), a second portion (32) having at least one retaining element (34b), an intermediate portion (33) devoid of retaining element and arranged between the first portion (31) and the second portion (32). |
| US11420431B2 |
Adhering jig and adhering method
An adhering jig includes a mounting plate having an upper surface, and a plurality of aligning parts incorporated in the mounting plate. A plurality of first holes are formed in the upper surface, and a plurality of first pins are engaged in the plurality of first holes, each having a base end and an upper end, and configured to be movable in a direction normal to the upper surface. A plurality of first adjusting members are located inward with respect to the upper surface. The plurality of first adjusting members are configured to support the plurality of first pins and to adjust movements thereof. The plurality of first adjusting members are, when the plurality of first pins are pressed in the first holes, configured to exert opposite force to the force applied through the plurality of first pins. |
| US11420426B2 |
Photochromic polyurethane laminate
A photochromic polyurethane laminate that is constructed to solve certain manufacturing difficulties involved in the production of plastic photochromic lenses is disclosed. The photochromic laminate includes at least two layers of a resinous material and a photochromic polyurethane layer that is interspersed between the two resinous layers and which contains photochromic compounds. The polyurethane layer is formed by curing a mixture of a solid thermoplastic polyurethane, at least one isocyanate prepolymer, at least one photochromic compound, and a stabilizing system. |
| US11420421B2 |
Glass sheet composite, and diaphragm
A glass sheet composite includes a first glass sheet, a second sheet disposed opposite the first glass sheet, and a liquid layer formed by sealing up a liquid between the first glass sheet and the second sheet, in which the glass sheet composite has a plurality of vibration areas that are independent of each other in a plan view. The glass sheet composite is a diaphragm including at least one vibrator disposed on one side or both sides of the glass sheet composite. The glass sheet composite enables independent vibration at each of the vibration areas, and enables not only stereophonic or multiphonic reproduction but also local reproduction to be performed along with images. Since the diaphragm includes a vibrator, this diaphragm is excellent in sound reproduction. |
| US11420417B2 |
Methods and apparatus for producing scored mediums, and articles and compositions resulting therefrom
Methods and apparatus for making scored mediums, particularly but not exclusively for use in the corrugated board arts, and articles of manufacture and compositions made there with and made there by. When at least one scored medium is used in a layered or laminated article, and particularly when selectively used as a liner member and/or fluted member in a corrugated board, whether as part of a corrugated board article of manufacture or a laminate with at least one other member, the article will possess mechanical qualities superior to those that would otherwise exist if a non-scored medium was/were used. To achieve these desired qualities, a major axis of the scores formed in the scored medium runs askew, and preferably perpendicular, to the direction of beam strength in any article or article intermediate to which the scored medium is to be associated. |
| US11420415B2 |
Three dimensional shaped article
The invention relates to a three dimensional shaped article having an outer and inner surface, the outer surface comprising at least one fabric (100) of polyethylene fibers having a tensile strength of at least 1.5 GPa, the fabric is impregnated with an acrylic based thermoplastic material. The three dimensional shaped article may further comprise monolayers with unidirectional aligned fibers. The three dimensionally shaped article has an improved surface appearance which would therefore need little or no post treatment and has good adhesion to coatings and paints. |
| US11420412B2 |
Quantum dot films, lighting devices, and lighting methods
Light-emitting quantum dot films, quantum dot lighting devices, and quantum dot-based backlight units are provided. Related compositions, components, and methods are also described. Improved quantum dot encapsulation and matrix materials are provided. Quantum dot films with protective barriers are described. High-efficiency, high brightness, and high-color purity quantum dot-based lighting devices are also included, as well as methods for improving efficiency and optical characteristics in quantum dot-based lighting devices. |
| US11420409B2 |
Method and device for controlling the traction of corrugated board in the double facer of a production line
The method includes the step of pulling the corrugated board along hot plates by means of an upper flexible member and a lower flexible member driven by two electric motors. By at least one electric parameter of the drive motor of the lower flexible member, the correct operation of the traction device and in particular the correct ratio of the linear feeding speeds of the two flexible members is checked. The method provides an iterative check of the controlled electric parameter and a possible correction of the speed of the flexible members to maintain the desired speed ratio. |
| US11420407B2 |
Die for a press and method for producing a green body by means of a press
The invention relates to a die for arrangement in a press, wherein the die extends along an axial direction between two end faces and forms an inner peripheral surface between the end faces, wherein the die extends from the inner peripheral surface along a radial direction toward an outer peripheral surface and toward at least one centering surface that is disposed in the radial direction on a first diameter, wherein the die has a pressing zone that is spaced apart from the end faces and, in the vicinity of the pressing zone, the die has a greater maximum first stiffness, at least relative to zones of the die that are arranged on the end faces, compared to a pressing force acting on the inner peripheral surface in a direction of a normal vector, and wherein the maximum first stiffness is at least 10% greater than a minimum second stiffness that is present in at least one zone that is arranged on one of the end faces. |
| US11420403B2 |
Contact lens manufacturing method
In manufacturing a contact lens, a contact lens mould arrangement in which the engagement between the mould halves is unconstrained and at least one mould half is sufficiently pliable or flexible that during the curing of the contact lens composition at one mold half may move or flex relative to the other to define a post-cure mould cavity of smaller volume than the precure mould cavity and during which the curvatures of the first and/or second mould surfaces are allowed to change provides a significantly more efficient manufacturing process and enables one mould half to be readily utilized as a blister cup for contact lens packaging. |
| US11420402B2 |
Tire puncture sealing agent and tire puncture repair kit
The present invention provides a tire puncture sealing agent having excellent storage performance, and a tire puncture repair kit. The tire puncture sealing agent of the present invention contains: a rubber latex and/or a resin emulsion; a predetermined glycol ether; and a non-ionic surfactant having an HLB value from 15 to 20. |
| US11420395B2 |
Region of interest monitoring and control for additive manufacturing
In some examples, with respect to region of interest monitoring and control for additive manufacturing, a blob detection analysis may be performed on first and second component images associated with additive manufacturing of a component, and blobs that remain a same shape and include same centroids on the first and second component images may be identified. A further blob detection analysis may be performed on first and second thermal images associated with the first and second component images, and a determination may be made as to whether one of the identified blobs includes a same shape and a different centroid between the first and second thermal images. Based on a determination that the one of the identified blobs includes the same shape and the different centroid, an indication of a thermal camera misalignment associated with the additive manufacturing may be generated. |
| US11420390B2 |
System for additively manufacturing composite structure
An additive manufacturing system is disclosed for use in fabricating a structure. The additive manufacturing system may include a support, and a print head configured to discharge a material and being operatively connected to and moveable by the support in a normal travel direction during material discharge. The print head may include a module located at a trailing side of the discharging material relative to the normal travel direction and being configured to compact the material and expose the material to a cure energy at a tool center point. |
| US11420389B2 |
Leveling system for 3D printer
A leveling system for a 3D printing system for laser dispensing includes inner and outer frames, each supported at its corners by respective actuators of first and second sets of actuators. The outer frame supports an optical plane within which material to be dispensed by laser irradiation is disposed. The inner frame supports a receiving medium plane within which a substrate on which said material to be dispensed by laser irradiation is disposed. Each actuator operates independently to displace a respective frame corner in the vertical direction. The inner and outer frames each is attached at their respective corners to a respective actuator by a rod, thus allowing the inner and outer frames to freely rotate with respect to one another. An additional frame may support sensors for monitoring the 3D printing system. |
| US11420387B2 |
Methods and apparatus for 3d printing of highly viscous materials
This disclosure generally relates to methods and apparatus for 3D printing of highly viscous materials, especially to high amplitude ultrasonic vibration facilitated lower temperature 3D printing of highly viscous materials with a viscosity of at least 1000 Pa·s. |
| US11420386B2 |
Nozzle structure applying RF heating device for 3D printer
A nozzle structure applying an RF heating device for a 3D printer, the structure includes: a nozzle unit for melting and discharging an inflowing material using heat transferred from the outside; a transfer unit for transferring the material to the nozzle unit; an RF nozzle heating unit for heating up the nozzle unit using a high frequency so that the material is melted in the nozzle unit; and a cooling unit for cooling down the heat discharged from the nozzle unit 100 to the outside. |
| US11420384B2 |
Selective curing additive manufacturing method
A method for producing a component layer-by-layer include the steps of: depositing a layer of particulate material having a first area over a build platform; applying a radiant-energy-curable binder to the layer so that a selected portion of the first area is uniformly coated with binder; selectively curing a second area of the layer smaller than the selected portion of first area, using an application of radiant energy in a specific pattern that defines the geometry of a cross-sectional layer of the component; and repeating the steps of depositing, applying, and curing for a plurality of layers until the component is complete. |
| US11420383B2 |
System and method for additively manufacturing components using containment walls
A system for additively manufacturing components includes a build chamber and a build plate on which a component and a containment wall surrounding the component are additively formed. The containment wall surrounds the component such that powder is present between the component and the containment wall, with the containment wall including first and second portions joined together at a separation line. Additionally, the build plate is positioned within the build chamber. Furthermore, a tooling assembly configured to split the containment wall at the separation line and pull the first portion of the containment wall away from the second portion of the containment wall while the build plate is present within the build chamber such that a portion of the powder is exposed. Moreover, a vacuum configured to remove the exposed portion of the powder from the build chamber while the build plate is present within the build chamber. |
| US11420381B2 |
Overlay applicator machine and method of providing the same
A machine can include a base including a first cradle. The first cradle can include a device slot being configured to securely hold a first electronic device. The machine also can include an alignment piece hingedly attached to the base at a hinge. The alignment piece can include an alignment base configured to engage with an alignment mechanism of an overlay applicator. The machine additionally can include a pulling piece movably attached to the base. The pulling piece can be configured to remove an adhesive release liner of the overlay applicator to expose an adhesive agent of an overlay of the overlay applicator when the alignment piece is rotated relative to the base around the hinge from a first alignment piece position to a second alignment piece position. Other embodiments are described. |
| US11420378B2 |
Core rod assembly for blow molding and having multiple temperature zones
A core rod assembly (10) for blow molding includes a core rod head (16), a first fluid pathway (A1) extending along a first length of the core rod head (16), and a second fluid pathway (A2) extending along a second length of the core rod head (16). The first and second fluid pathways (A1, A2) may be fluidly isolated from each other and provide selective temperature control of respective first and second portions of the core rod assembly (10) during the blow molding process. At least a portion of the first fluid pathway (A1) may be longitudinally offset from the second fluid pathway (A2) so as to define respective first and second temperature zones (zone 1, zone 2) along the respective first and second portions of the core rod assembly (10). |
| US11420376B2 |
Extrudable oriented polymer composites
A novel tubular or profile shapes of co-extruded multilayer polymers. These materials contain tens to thousands of layers of milli-, micro- to nano-polymer layers. These new shapes contain contiguous layers of milli- to nano-polymer layers in three dimensions and these contiguous layers may be twisted or turned to further expand the potential microlayer geometries. |
| US11420375B2 |
Extruder and method for extruding cord reinforced tire components
Disclosed is an extruder and a method for extruding cord reinforced tire components, wherein the extruder includes an extruder head with a die and a cord guide, wherein the die is provided with a cross sectional profile that defines a first cross section of the extrusion material in the die, wherein the cross sectional profile has a profile height, wherein the cord guide is arranged for guiding the cords into the die at a cord entry height, wherein the extruder head is provided with first heating elements, wherein the extruder comprises a control unit that is operationally connected to the first heating elements for generating an adjustable height temperature gradient in the extrusion material across the profile height to control swelling of the extrusion material relative to the cord entry height from the first cross section to a second cross section after the extrusion material leaves the die. |
| US11420368B2 |
Method for the preparation of composite material in sandwich form
The object of the invention can be a method of manufacturing a product in the form of a sandwich comprising a core and outer layers. The outer layers may be composed of composite material comprising a fiber-reinforced polymeric matrix. The method uses an insert of heat-resistant material, for example silicone. The object of this invention can be to provide a method of manufacturing a sandwich that dissociates the choice of material of the core of the sandwich from the choice of the material of the outer layers. |
| US11420366B2 |
Method of manufacturing a stiff engineered composite
The method of making a compressed biocomposite body includes compressing a mass of biocomposite material comprised of discrete particles and a network of interconnected glucan-containing mycelia cells in the presence of heat and moisture into a compressed body having a density in excess of 18 pcf. Compression may take place batch wise in a press or continuously in a path of narrowing cross-section defined by a series of heated rollers. |
| US11420363B2 |
Vehicular interior material manufacturing method
Provided are a vehicular interior material manufacturing method and a vehicular interior material, the method comprising the steps of: forming a molded article including a surface having an uneven shape; and forming a printing layer on the surface of the molded article by using a predetermined blanket. |
| US11420359B2 |
Glass-plate working apparatus
A glass-plate working apparatus 1 includes a cutting section 2 serving as a processing position for forming cut lines on a glass plate 5, a grinding section 3 serving as a processing position for grinding peripheral edges of the glass plate 5, a bend-breaking section 4 serving as a processing position between the cutting section 2 and the grinding section 3, and a glass-plate transporting section 6 for transporting the glass plates 5, and further includes a feed conveyor 7 disposed on the side of carrying in to the cutting section 2 and serving as a glass-plate carrying-in section, as well as a discharge conveyor 8 disposed on the side of carrying out from the grinding section 3 and serving as a glass-plate carrying-out section. |
| US11420352B2 |
Shaving device comprising an autotightening spring device for assembling a removable cartridge with an handle
A shaving device comprising a handle and a removable cartridge, the handle comprising a gripping portion extending along an axis and a first coupling portion arranged at an axial end of the gripping portion, the removable cartridge comprising a shaving head and a second coupling portion, the first coupling portion and the second coupling portion being configured to be removably coupled together for assembling the removable cartridge with the handle, a first element among the first coupling portion and the second coupling portion comprising an auto-tightening spring device configured to lock a second element among the first coupling portion and the second coupling portion with the first element when the second coupling portion is moved axially toward the gripping portion and cooperates with the first coupling portion. |
| US11420351B2 |
Adjustable shaving blade assembly
A shaving blade assembly is provided. The shaving blade assembly comprises a blade, one or more blade retainers, a first resilient element pressing the blade against the blade retainer in a first direction along a first axis that is orthogonal to a cutting edge of the blade, and a first rack-and-pinion mechanism with a rack operationally coupled to the first resilient element and a pinion for actuating a motion of the rack along the first axis. |
| US11420349B2 |
Hair clipper comprising a comb
This application concerns a comb (200) for a hair clipper comprising a comb portion (208) comprising a plurality of comb teeth (216) having slots formed there between for guiding hairs to a cutting element of the hair clipper. The comb portion may be configured such that, when the comb is attached to the hair clipper, a substantially wedge-shaped hair debris-receiving space is formed between the housing and the comb portion into which hair debris can flow. The comb teeth may comprise an extension portion (230) which extends generally forwardly away from the respective comb tooth in a cutting movement direction such that a connecting bar is spaced apart from a housing of the hair clipper by a greater distance than the plurality of comb teeth. |
| US11420345B2 |
Robot
A robot including: two link members with longitudinal axes that are coupled such that the link members are able to relatively rotate about an axial line; and a sensor that detects a force around the axial line acting between the link members due to an object pinched between the link members, in which the robot has such a shape that a width dimension in a direction along a plane of a cross-sectional surface of at least one of the link members, which perpendicularly intersects the axial line, on at least one sides from the longitudinal axes that intersect the axial line continuously spread from at least midway positions of the at least one of the link members in the direction of the longitudinal axes toward the axial line, respectively. |
| US11420339B2 |
Article holding device and article holding system
A holding technology whereby an article, i.e., a subject to be held, can be stably held by increasing a contact area with respect to the article. An article holding device includes a holding main body, a suction mechanism, and a sandwiching mechanism. The sandwiching mechanism includes sandwiching arms, which come into contact with one side of the article, and a board-like sandwiching plate that comes into planar contact with the other side of the article. |
| US11420338B2 |
Assistive robot systems for container tilting
Embodiments are directed to an assistive robot system. The assistive robot system includes a lifting mechanism, a movable arm assembly coupled to the lifting mechanism, a container tilting arm assembly, a processing device communicatively coupled to the lifting mechanism and the movable arm assembly, and a non-transitory, processor-readable storage medium in communication with the processing device. The non-transitory, processor-readable storage medium causes the processing device to transmit a command to the lifting mechanism to cause the lifting mechanism to move the movable arm assembly such that the container tilting arm assembly makes contact with a container and transmits one or more signals to the movable arm assembly to cause the movable arm assembly to extend in a system longitudinal direction such that the container within the movable arm assembly is pivoted against the container tilting assembly to tilt the container within the movable arm assembly. |
| US11420333B2 |
Robot and method for controlling a robot
A robot having a robot manipulator with an effector, wherein the robot manipulator is designed and constructed for picking up, handling, and releasing an object and is controlled by a control unit, the robot including a first sensor means designed and constructed to determine a persisting adherence of the object to an effector after a release of the object by the effector, and where such an adherence persists, to generate a signal S, wherein when a signal S is present, the control unit is designed and constructed to control the robot manipulator in such a manner that it executes a predefined movement B in which the effector with the persistently adhering object is passed by a wiping object in such a manner that the adhering object is wiped off the effector on a surface or an edge of the wiping object. |
| US11420332B2 |
Method of adjusting posture of 6-axis robot
A method of adjusting a posture of a 6-axis robot standing in a direction perpendicular or substantially perpendicular to a robot mounting surface includes specifying axis central positions of three axes located at different heights in the direction perpendicular or substantially perpendicular to the robot mounting surface of the 6-axis robot, specifying two planes including two arcs of which rotation centers are represented by two axes farther away from the robot mounting surface among the three axes, specifying a position of a predetermined point on the arc farther away from the robot mounting surface among the two arcs, and determining an angle adjustment amount of the three axes in a rotation direction and an angle adjustment amount of an axis extending between the two axes in a rotation direction based on the specified axis central positions of the three axes, the specified two planes, and the specified position of the predetermined point. |
| US11420330B2 |
Robot control device, robot, and simulation device
A robot control device according to an aspect of the invention is a robot control device that controls a robot on the basis of a simulation result of a simulation device that performs a simulation of operation of a virtual robot on a virtual space. In the simulation, a first region and a second region located on an inside of the first region can be set on the virtual space. In the case where the virtual robot operates, when a specific portion of the virtual robot intrudes into the first region, operating speed of the virtual robot is limited. When the specific portion of the virtual robot intrudes into the second region, the operation of the virtual robot stops or the virtual robot retracts from the second region. |
| US11420329B2 |
Processing systems and methods for providing processing of a variety of objects
A sortation system is disclosed that includes a programmable motion device including an end effector, a perception system for recognizing any of the identity, location, and orientation of an object presented in a plurality of objects, a grasp selection system for selecting a grasp location on the object, the grasp location being chosen to provide a secure grasp of the object by the end effector to permit the object to be moved from the plurality of objects to one of a plurality of destination locations, and a motion planning system for providing a motion path for the transport of the object when grasped by the end effector from the plurality of objects to the one of the plurality of destination locations, wherein the motion path is chosen to provide a path from the plurality of objects to the one of the plurality of destination locations. |
| US11420327B2 |
Automated control of multi-process using robotic equipment for complex workflows
An approach for fully automating the use of robotic devices in a laboratory workflow includes defining sequences for automating tasks and equipment involved in such a workflow, and calculating a path for each sequence that resolves get, handoff, and placement procedures. The approach develops a schedule that executes resolved pathways in and between each device. The approach is provided with an easy-to-use interface, in which a user drags and drops devices to automatically configure them, defines operations to be performed by these devices, and then runs the laboratory workflow. The interface also provides the ability to monitor progress of the workflow, and make modifications and adjustments as needed. |
| US11420317B2 |
Locationing device for a machining point on a workpiece
A device for determining a location on an elongated workpiece, characterized in that the device comprises: a frame movable in a first direction, preferably in a longitudinal direction of the workpiece, positioning means to position the frame in relation to the sides of the workpiece, movable means movable in a second direction, preferably in a transverse direction with respect to the frame, a measuring point, the movement in first direction and second direction used to move measuring point in said directions, measuring equipment for determining the location of the measuring point in transverse and longitudinal respect to the workpiece. |
| US11420315B2 |
Handheld machine tool
A handheld machine tool, which has a housing including a handle, a drive motor situated inside the housing, and an interface for establishing a mechanical and/or an electrical connection between the handheld machine tool and a battery pack, the interface having a base element for the electrical and/or mechanical connection of the interface to the handheld machine tool, and a separate contact carrier including at least one contact element for the electrical and/or mechanical contacting with at least one corresponding mating contact element on the battery pack. |
| US11420314B2 |
Impact tool
An impact tool includes a switch for driving the tool accessory, an operation member configured to be movable between an OFF position and an ON position, a first lock member configured to lock the operation member in the ON position, a second lock member configured to be movable between a lock position and a lock-release position in response to an external operation by a user, and a holding mechanism configured to hold the second lock member in the lock position and also in the lock-release position. The second lock member in the lock position is capable of locking the operation member in the OFF position, and the second lock member in the lock-release position is incapable of locking the operation member in the OFF position. |
| US11420311B2 |
Insert insertion tool and method for inserting insert
An insert insertion tool includes a mandrel on which an insert is mounted, and a coating member. The coating member is configured to apply ink to a rear end of the insert on an opposite side of a tip end of the insert that first enters a tap hole. Accordingly, the insert inserted into the tap hole stands out on a surface of a workpiece, and a user is capable of visually recognizing whether or not the insert has been inserted into the tap hole. Thus, the confirmation work becomes easy, and it is possible to improve the work efficiency. |
| US11420308B2 |
Impact tool
An impact tool includes a second spring with restricted free movement. The impact tool includes a motor, a spindle rotatable with a rotational force generated by the motor, a hammer supported by the spindle in a manner movable in a front-rear direction and in a rotation direction, an anvil to be struck by the hammer in the rotation direction, a first spring constantly urging the hammer forward, a second spring that urges, forward, the hammer moving backward from a reference position, a hammer case accommodating the hammer, the first spring, and the second spring, and a movement restrictor that restricts movement of the second spring in an internal space of the hammer case. |
| US11420305B2 |
Method for electrostatically scattering an abrasive grain
A method for electrostatically scattering an abrasive grain includes applying at least one electro-conductive material to the abrasive grain. The electro-conductive material is in the form of at least one organic compound. |
| US11420298B2 |
Method of making a heat exchanger
A method of making a heat exchanger that includes sealing tubes to header slots and brazing the tubes to the header slots. The method further includes coupling a cover to the header to cover a liquid-side surface of the header and to cover ends of the tubes, and applying flux to an air-side surface of the header and to the tubes. Coupling the cover to the header is performed after sealing the tubes to the header slots and coupling the cover to the header is performed before applying flux to the air-side surface of the header and to the tubes. Applying flux is performed before brazing each of the tubes to the header slots and sealing each of the tubes to the header slot includes sealing a perimeter of each of the tubes to the header slot. |
| US11420295B2 |
Exothermic cutting rod with ignition window
An exothermic cutting rod comprising an ignition assembly portion and a main portion. The main portion may comprise a plurality of fuel rods and a rod housing that is configured to allow a flow of oxygen to the ignition assembly portion. The ignition assembly portion may comprise an ignition fuel housing and an ignition fuel, which is entirely contained within said exothermic cutting rod. The ignition fuel housing may have one or more windows that are configured to allow a heat source to ignite the ignition fuel, which then in turn ignites the fuel rods. |
| US11420294B2 |
Wafer processing method
A wafer processing method is disclosed to divide a wafer of glass substrate into individual chips along division lines. In the shield tunnel forming step, a pulsed laser beam of a wavelength, which transmits through the wafer, is irradiated with its focal point positioned at a region corresponding to each division line so that a plurality of shield tunnels which are each formed of perforations and affected regions surrounding the perforations are formed along the division lines, respectively. In the modified layer forming step, another pulsed laser beam of a wavelength, which transmits through the wafer, is irradiated with its focal point positioned at the region corresponding to each division line so that modified layers are formed in addition to the shield tunnels along the division lines, respectively. In the dividing step, an external force is applied to the wafer to divide the wafer into individual chips. |
| US11420292B2 |
Cutting a workpiece
A method for cutting a workpiece includes cutting the workpiece along a predefined cutting contour to separate a workpiece part from a scrap part, and checking whether the workpiece part has been fully separated from the scrap part during the cutting. The workpiece is re-cut along an additional cutting contour laterally offset from the predefined cutting contour if it is found during the checking that the workpiece part has not been fully separated from the scrap part. The disclosure also relates to an associated machine for cutting a workpiece. |
| US11420291B2 |
Projection forming method and machine
A projection forming method forming a projection on the surface of a work and includes: forming a first bank by LMD such that the first bank surrounds a projection forming region on the surface of the work; forming a first layer on the projection forming region by the LMD such that the first layer covers the first bank; laminating at least one first height raising layer on the first layer by the LMD; forming a second bank by the LMD along a peripheral edge of the at least one first height raising layer; forming an intermediate base layer on the at least one first height raising layer by the LMD such that the intermediate base layer covers the second bank; and laminating at least one second height raising layer on the intermediate base layer by the LMD. |
| US11420290B2 |
Laser welding method and laser welding apparatus
A laser welding method includes a welding process of irradiating a multiple laser beam so as to weld together a first member and a second member at a boundary. The multiple laser beam includes a first beam that is advanced while forming a first molten pool in which the first member is melted, a second beam that is advanced while forming a second molten pool in which the second member is melted, and a main beam that is advanced subsequently to the first beam and the second beam and irradiated to an integrated molten pool formed by integration of the first molten pool and the second molten pool. The first beam and the second beam do not swing, while the main beam swings with respect to the boundary. |
| US11420287B2 |
Wire clamping system for fully automatic wire bonding machine
A wire clamping system for fully automatic wire bonding machine comprises a base, a wire clamping support, a wire clamping assembly, a driving mechanism and an elastic assembly. The wire clamping assembly can move relative to the capillary, so that when the wire clamping system completes the second bond, the metal wire at the end of the capillary may directly extend out of the capillary by the independent movement of the wire clamping assembly and a length thereof can be effectively controlled, in order to form a metal ball in the next first bond. Furthermore, when the wire clamping system completes the second bond, the wire clamping assembly is in a clamping state, which avoids wires flying, even though the second bond is not firmly connected or the machine vibrates. |
| US11420280B2 |
Closed socket brazed joint assembly
A closed socket brazed joint assembly is provided. The assembly comprises: a first member composed of a first base material; a second member composed of a second base material with a first end composed of a first profile with at least first and second faying surfaces; a socket formed in said first member configured to receive the first end of the second member with a faying surface with at least two portions separated by a first fillet; wherein the socket further is configured such that in a first state before the application of energy to the joint there is a gap with a width between the faying surfaces of the first member and the faying surfaces of the second member; and, in the first state a slug of brazing fill material is disposed between the first end of the second member and at least one faying surface of the socket; and, wherein a second state is created when upon application of energy the brazing fill material melts and flows from between first end of the second member and the at least one faying surface of the socket filling aforesaid gap between the faying surfaces of the first and second members. |
| US11420276B2 |
Filing and fastener driving bit assembly
A filing and fastener driving bit assembly for deburring the end of a pipe includes a shaft that has a first end and a second end. A first section of the shaft that is positioned adjacent to the first end is hexagonally shaped. The first section is insertable into a chuck of a rotary tool to couple the shaft to the rotary tool. A second section of the shaft that is positioned between the first section and a second end of the shaft is textured. The second section is used to file an edge of a tubular substrate, such as Electrical Metallic Tubing, as the shaft is rotated by the rotary tool. A screwdriver tip that is coupled to the second end of the shaft is insertable into a complementary head of a fastener, positioning a user to utilize the rotary tool to drive the fastener. |
| US11420275B2 |
Machine for cutting nozzles of reactor vessels
Disclosed herein is a machine for cutting nozzles of reactor vessels. The machine for cutting nozzles of reactor vessels comprises a cutting unit positioned at an upper surface edge of a reactor vessel having a nozzle and having a saw blade part having different contact areas to cut the nozzle, a drive unit providing the saw blade part with rotary power, and a foreign substance suction unit provided at one end of the cutting unit in contiguity with the saw blade part to suck foreign substances generated when the nozzle is cut by the saw blade part, wherein the foreign substance suction unit sucks the foreign substances by approaching an outer peripheral surface of the nozzle when the saw blade part moves in a cutting direction of the nozzle. |
| US11420273B2 |
Rotary cutting tools and applications thereof
In one aspect, rotary cutting tools are described herein comprising sets of coolant channels having exit aperture in the flutes of the tools for efficient coolant delivery to multiple cutting surfaces. Briefly, a rotary cutting tool comprises a shank portion, and a cutting portion extending from the shank portion along a longitudinal axis, the cutting portion comprising flutes helically extending along the longitudinal axis and internal coolant channels comprising exit apertures in the flutes. A projection of an exit aperture of a first set of internal coolant channels intersects a rake face extending below a corner edge of the rotary cutting tool, and a projection of an exit aperture of a second set of internal coolant channels intersects a rake face below a radial cutting edge of the rotary cutting tool. |
| US11420268B2 |
Kit to assist in the manual change of a tool from a rotary tool holder
A known rotary tool holder (10) comprises a rotary tool gripper (11) and a non-rotary part (16) presenting a flat front wall (18), the rotary tool gripper projecting from the flat front wall and comprising a shaft segment (15) having two shaft flats (12, 13). A kit to assist in the manual change of a tool from such a rotary tool holder comprises a forked holding element (20) provided with two fingers (22, 23) that are suitable to be fitted by their inside on the two shaft flats, and a locking plate (30) that comprises a recess (31) and is suitable to be fixedly mounted on the front wall with the recess facing it, said recess being configured to house the two fingers fitted on the two shaft flats when the locking plate is mounted on the front wall, the recess extending across the locking plate and being delimited by two steps (32, 33) against which the two fingers can be fitted by their outside. |
| US11420262B2 |
Systems and methods for co-casting of additively manufactured interface nodes
Systems and methods for co-casting of additively manufactured, high precision Interface Nodes are disclosed. The Interface Node includes an integrated structure including one or more complex or sophisticated features and functions. Co-casting of Interface Nodes by casting a part onto the Interface Node results in a hybrid structure comprising the cast part and the additively manufactured Interface Node. The interface node may include at least one of a node-to-tube connection, node-to-panel connection, or a node-to-extrusion connection. In an embodiment, engineered surfaces may be provided on the Interface Node to improve the blend between the Interface Node and the cast part during the co-casting process. |
| US11420261B2 |
System for producing three-dimensional objects
A system (1) for producing three-dimensional objects (2) by way of the solidification above one another of layers of a building material which can be solidified by means of radiation at the points which correspond to the respective cross section of the object, wherein the system (1) comprises at least one process station (4) which is arranged in a first housing (3) for carrying out the layer-by-layer generative building process in a building container (5), and a handling station (7) in at least one second housing (6) for unpacking produced objects (2) from the building container (5) which can be moved between the at least one process station (4) and the at least one handling station (7), wherein the at least one process station (4) and the at least one handling station (7) are arranged in separate housing units (3, 6). |
| US11420260B2 |
Method of manufacturing fabricated object
A method of manufacturing a fabricated object includes forming the fabricated object by laminating metal powder, the fabricated object including an opening portion that communicates with a hollow internal space, mounting a plug in the opening portion, and welding the plug mounted in the opening portion to the fabricated object. |
| US11420257B2 |
Device and method for high-efficiency preparation of spherical metal powder for 3D printing employing separation into fibers
An apparatus for efficiently preparing spherical metal powder for 3D printing includes a housing, a crucible and a powder collection area arranged in the housing, wherein a turnplate arranged in the collection area is an inlaid structure. A material having a poor thermal conductivity is selected as the base of the turnplate, and a metal material having a wetting angle less than 90° with respect to droplets is selected and embedded into the base to serve as an atomization plane of the turnplate. An air hole is disposed in the turnplate. The spherical metal powder for 3D printing combines electromagnetic force breaking capillary jet flow and centrifugal atomization, which breaks through the traditional metal split mode, and makes the molten metal in a fibrous splitting. |
| US11420252B2 |
Punch pin assembly and die casting machine having punch pin assembly
A punch pin assembly includes a punch rod, a punch pin and a punch pin connection rod connected therebetween. A heat-conducting medium conveying loop is arranged in the punch rod and the punch pin connection rod. The heat-conducting medium conveying loop communicates with the outside of the punch rod separately through a first medium port and a second medium port which are formed in the punch rod. |
| US11420251B2 |
Casting mold and process for manufacturing a crankcase
A casting mold for a crankcase of an internal combustion engine includes a water jacket core which has a frame core and a cooling duct core. A land core is provided which is designed and positioned in such a way as to form a cooling duct in an inter-cylinder land of a crankcase. The land core is retained in the frame core and is, or can be, centered using a top core. |
| US11420250B2 |
Mold material, method of producing the same, and method of producing casting mold
Provided are: a mold material having improved fluidity and being capable of improving a filling rate of a forming mold during formation of a casting mold; and a mold material that gives cast products a favorable casting surface, effectively improves sand adhesion on cast products, and advantageously provides a casting mold having excellent strength. The mold material is formed as a coated sand in a wet state with spherical particles of silicone resin having binder repellency existing on its surface, by at least mixing a water-soluble inorganic binder in the liquid state having a viscosity of not more than 1000 cP, and the spherical particles of silicone resin, with a refractory aggregate. |
| US11420245B2 |
Machine for the working of tubes provided with a device for detecting any slippage of the tube being worked
The machine comprises a working apparatus arranged to carry out the working operation on a tube, or a similar blank, and a tube feeding device arranged to feed the tube towards the working apparatus. The working apparatus and the tube feeding device comprise respective clamping members for clamping the tube being worked. According to the invention, at least one of the clamping members of the working apparatus or of the tube feeding device is provided with a displacement sensor arranged to detect and measure any movements of the tube relative to said clamping member while the tube is clamped by said clamping member during the working operation. |
| US11420243B2 |
Device for guiding metal strips with wear bodies in a finishing train
A device for laterally guiding a metal strip (1, 13) running over a loop lifter (4, 12) between two roll stands (2, 3, 8, 9) of a finishing train. The device includes at least one main member module (14) extending in a direction between the roll stands. The module has a guiding plane (15), and also supports a number of wear members (18, 19, 20), each with a wear surface (21, 22, 23). Those wear members can be turned to a number of rotational positions. At least two wear members (18, 19, 20) are respectively arranged between one of the roll stands (2, 3, 8, 9) and the loop lifter, wherein, seen in the direction of the loop lifter (4, 12), the surface area of the wear surface (21, 22, 23) of adjacent wear member bodies (18, 19, 20) increases. During the operation of the device, at least one of the wear members is rotated while the metal strip (1, 13) is running to expose another area of the wear surface to the side of the strip. |
| US11420242B2 |
Reformer assembly
A base reformer assembly, and/or a base reformer roller die unit, includes a generally torpid chuck, a roller die, and a roller die unit actuating assembly. The roller die is movably disposed within the chuck. The roller die unit actuating assembly is structured to actuate the roller die. The roller die unit actuating assembly is operatively coupled to the roller die. Further, all elements of the roller die unit actuating assembly have a robust cross-sectional area. |
| US11420237B2 |
System for cleaning metallic scraps from organic compounds
An installation for melting metallic scraps, and particularly adapted for melting aluminium scraps, includes a system for cleaning the metallic scraps, and in particular for cleaning the scraps from organic compounds. |
| US11420236B2 |
Ultrasonic cleaner and automatic analyzer using the same
Stable operation of an ultrasonic vibrator of an ultrasonic cleaner and scattering prevention of a washing liquid are provided. The ultrasonic cleaner includes a washing tank 206 in which a washing liquid is reserved; an ultrasonic vibrator 205; a vibration head 209 provided with a neck 304 extended from the ultrasonic vibrator to the washing tank and a tip end portion 210 having a cylindrical hole 211 whose longitudinal direction is oriented to a perpendicular direction; and a first cover 601 having an opening corresponding to the neck and the cylindrical hole, in which the first cover is arranged to a height in contact with a liquid surface of the washing liquid such that it covers the washing tank. |
| US11420232B2 |
Vibration generator and method for generating vibrations
A vibration generator has a first rotationally drivable imbalance shaft, on which a first imbalance is arranged, at least one second rotationally drivable imbalance shaft, on which a second imbalance is arranged, a joint drive for rotationally driving the two imbalance shafts and a transmission arrangement which is arranged between the drive and the imbalance shafts for transmitting a torque of the drive to the imbalance shafts. The transmission arrangement distributes an input torque of the drive to a first output element for the first imbalance and a second output element for the second imbalance. For the torque transmission a first deflection element is arranged between the transmission arrangement and the first imbalance shaft and for the torque transmission a second deflection shaft is arranged between the transmission arrangement and the second imbalance shaft. |
| US11420230B2 |
Assemblies and processes for producing optical effect layers comprising oriented non-spherical oblate magnetic or magnetizable pigment particles
The present invention relates to the field of optical effect layers (OEL) comprising magnetically oriented non-spherical oblate magnetic or magnetizable pigment particles on a substrate, spinneable magnetic assemblies and processes for producing said optical effect layers (OEL). In particular, the present invention relates to spinneable magnetic assemblies and processes for producing said OELs as anti-counterfeit means on security documents or security articles or for decorative purposes. |
| US11420229B2 |
Method and apparatus for producing a decorative surface
A method for producing a decorative and structured surface with different gloss levels by feeding of a workpiece to a lacquer application device, application of a first liquid lacquer layer over an entire surface with a coarse structure in which a difference in thickness between thicker areas and thinner areas is at least 50 μm, in order to apply a second lacquer layer on the first lacquer layer wherein after curing the second lacquer layer has a different gloss level than the first lacquer layer. |
| US11420226B2 |
Method for forming multilayer coating film
An object achieved by the present invention is to provide a coated article having excellent appearance, corrosion resistance, weatherability, and chipping resistance obtained by a wet-on-wet coating. The present invention provides a method for forming a multilayer coating film comprising the steps of forming, on a substrate, an uncured coating film of a primer paint composition (A) containing an epoxy resin (a1) having a weight average molecular weight of 20000 or more and pigments, forming, on the uncured coating film, a top coating film of a top paint composition (B) containing an acrylic resin (b1) and the like, and simultaneously drying the films, wherein the uncured coating film of the primer paint composition (A) during application of the top paint composition (B) has a viscosity of 5 Pa·s to 1000 Pa·s, and the value ΔNV obtained by subtracting the value (NV1) of application mass solids content (%) of the primer paint composition (A) from the value (NV2) of mass solids content (%) of the uncured coating film of the primer paint composition (A) during the application of the top paint composition is 15 or more. |
| US11420225B1 |
Material dispense tips and methods for forming the same
A dispense tip constructed and arranged to communicate with a material dispensing pump comprises an elongated neck and a molded base having a first portion and a second portion opposite the first portion. The neck extends from the first portion of the base. The second portion is constructed and arranged to abut an outlet surface of the pump. An outermost region of the second portion of the base includes a compressible fluid-tight surface that compliantly conforms to the outlet surface when the dispense tip is mounted to the pump. |
| US11420221B2 |
Portable chemical sprayer system
A system for combining and spraying fluids that includes a principal reservoir for holding a carrier fluid; an electric pump in communication with the principal reservoir; a power source for energizing the pump selectable between a rechargeable 12-volt battery and a 110-volt AC line; at least one auxiliary reservoir for holding an auxiliary fluid to be controllably mixed with carrier fluid being drawn from the principal reservoir; a selector valve for selecting which if any of the auxiliary fluid(s) are to be combined with the carrier fluid; a Venturi tube for combining streams of carrier fluid and selected auxiliary fluid(s) in a predetermined ratio which may be varied as desired; and a spray wand in fluid communication with the Venturi tube for discharging the selected fluids. |
| US11420218B1 |
Spray nozzle for low clearance spraying with flow seal
A two-part spray nozzle with body and head parts which are joined together is disclosed. The body and head include channels in planar surfaces which are ultimately joined with the channels in alignment. An elastomer, preferably having a cylindrical shape is inserted into the channel to provide a fluid tight seal between the head and body. |
| US11420215B2 |
Method for emptying solids from a centrifuge
A method for clarifying a flowable starting product of solids using a self-emptying centrifuge in continuous operation in a centrifugal field in the rotating drum. A continuous draining of at least one clarified liquid phase occurs and solids emptying occurs repeatedly via outlet openings that are intermittently opened and closed. The emptying of solids from the drum of the centrifuge is initiated, the speed of the drum of the centrifuge is reduced, the solids are emptied from the solids collection chamber of the drum after lowering the speed of the drum, and the emptying of the solids from the drum is ended. |
| US11420210B2 |
Stackable consumable carrier with locking device and handling interfaces
A carrier for consumables which are mainly used in laboratory (analytic) applications and provides a carrier for consumables, comprising a ground plate with at least two cut-outs for accommodating a consumable, a clamp plate with at least one clamp extending partially above the cut-outs and a locking lever movably connected with the clamp plate, wherein the locking lever has at least a cam located at an end connected with the clamp plate, wherein the cam presses in a locking position of the locking lever the clamp plate towards the ground plate and releases in a releasing position a gap between ground plate and clamp plate. |
| US11420207B2 |
Reaction receptacle
A receptacle includes an upper portion having a cylindrical portion and an open end and a lower portion depending from the upper portion, where the lower portion is tapered and has a closed bottom end. The receptacle may include a radially-extending annular ring with a flat or sloped bottom surface and disposed on an outer surface of the receptacle at a transition between the upper portion and the lower portion and/or a radially-projecting lip circumscribing the open end, which may be configured for inter-locking engagement with a mated cap inserted into the open end of the upper portion. Embodiments may include one or more longitudinally-oriented grooves formed in an inner surface of the upper portion. The receptacle may be a unitary plastic structure. |
| US11420206B2 |
Measuring cuvette for counting and/or characterizing cells
A measuring cuvette for counting and/or characterizing cells, the measuring cuvette including a base and a transparent lateral enclosure extending from the base so as to form with the latter an optical measurement chamber; the base having a through-orifice with a diameter of 30 to 100 μm for cells to pass through, characterized in that the base and the transparent lateral enclosure form a one-piece cuvette suitable both for impedance measurement and for optical measurement. Also, a system for characterizing cells, which includes the measuring cuvette. |
| US11420201B2 |
Compact testing device
A lateral flow testing device includes a main body adapted to support an element for collecting a sample. The element is supported at a distal end of the testing device and is in fluid communication with one or more testing components having an analyte detection zone for detecting one or more analytes present in said sample. The testing components produce visual information related to said sample, thereby informing the user of the outcome of a test. The device incorporates a handle reconfigurable with respect to said main body such that in a first handle configuration, the handle hinders sight of the visual information to improve privacy of the test, and in a second handle configuration, the handle facilitates the collection of said sample by increasing a distance between a proximal end of the testing device and the element. |
| US11420200B2 |
Cover member, method and treatment module for treating a biological sample on a substrate
A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member. |
| US11420199B2 |
Liquid processing module, liquid testing system and testing method
The disclosure is related to a liquid processing module, a liquid testing system and a testing method. The liquid processing module includes a base, a first valve and at least one negative pressure generator. The base has a first groove and at least one first opening. The first opening is connected to the first groove. The first valve is slidably located in the first groove. The negative pressure generator is configured to generate or remove negative pressure at the first opening in response to the first opening and the first groove being connected with each other. |
| US11420196B2 |
Processes for producing fluorided solid oxides and uses thereof in metallocene-based catalyst systems
Disclosed herein are methods for preparing fluorided solid oxides by contacting an acidic fluorine-containing compound with an inorganic base to form an aqueous mixture having a pH of at least 4, followed by contacting a solid oxide with the aqueous mixture to produce the fluorided solid oxide. Also disclosed are methods for preparing fluorided solid oxides by contacting an acidic fluorine-containing compound with a solid oxide to produce a mixture, followed by contacting the mixture with a inorganic base to produce the fluorided solid oxide at a pH of at least about 4. The fluorided solid oxide can be used as an activator component in a catalyst system for the polymerization of olefins. |
| US11420194B2 |
Visible light catalyst, preparation and application thereof
A visible light catalyst, its preparation method, a visible light catalyst activated persulfate system and its use. The visible light catalyst includes a carbon material, a transition metal compound and a coating material. The carbon material is conductive carbon material, and the transition metal compound is selected from one or more of transition metal oxides, transition metal sulfides, and acid or salt compounds containing a transition metal. The visible light catalyst has high visible light photocatalytic activity and performance of degrading organic pollutants and activating persulfate which can result in synergistically degrading degradation-resistant organic pollutants. |
| US11420192B2 |
Hydrocracking catalysts containing rare earth containing post-modified USY zeolite, method for preparing hydrocracking catalysts, and methods for hydrocracking hydrocarbon oil with hydrocracking catalysts
In accordance with one or more embodiments of the present disclosure, a catalyst composition includes a catalyst support and at least one hydrogenative component disposed on the catalyst support. The catalyst support includes at least one USY zeolite having a framework substituted with titanium and zirconium. The framework-substituted USY zeolite comprises at least one rare earth element. Methods of making and using such a catalyst in a hydrocracking process are also disclosed. |
| US11420190B2 |
Process for preparing porous iron oxide-zirconia composite catalyst, porous iron oxide-zirconia composite catalyst prepared thereby, and method for producing alcohol using the catalyst
The present invention relates to a porous iron oxide-zirconia composite catalyst, a preparation method thereof, and a method for producing alcohol using the same, and the iron oxide-zirconia composite catalyst having a porous structure may produce alcohol at low cost by carrying out an excellent methane reforming reaction even under room temperature and room pressure conditions through an electrochemical reaction. |
| US11420184B2 |
Water-absorbent resin particle
Disclosed are water-absorbent resin particles comprising a crosslinked polymer comprising a monomer unit derived from a water-soluble ethylenically unsaturated monomer, wherein an artificial menstrual blood volume increase rate as measured in an artificial menstrual blood swelling test conducted in the order of i), ii), and iii) is 70% or more. i) putting 1.0 g of water-absorbent resin particles into a measuring cylinder with an inner diameter of 27 mm. ii) injecting 10 ml of artificial menstrual blood into the cylinder at once to swell the water-absorbent resin particles. iii) measuring a volume (A) of the swollen water-absorbent resin particles after 60 seconds from the injection and calculating an artificial menstrual blood volume increase rate according to Equation (I) below. Artificial menstrual blood volume increase rate (%)=(A−B)/B×100 . . . (I), A . . . Volume (ml) of swollen water-absorbent resin particles, B . . . Volume (ml) of injected artificial menstrual blood. |
| US11420182B2 |
Hydrophobic sorbents for CO2/H2O displacement desorption applications
The disclosure generally relates to CCS sorbents, particularly for CO2/H2O displacement desorption process. The sorbent includes an aluminum oxide support and an alkali metal salt impregnated on the support, and a silicon modification of the sorbent to reduce water uptake by the sorbent and make it more hydrophobic. The silicon modification can be an organosilyl moiety added after the initial sorbent is complete, or a silica source added to the aluminum oxide structure, typically via impregnation. The sorbents demonstrate better H2O/CO2 ratios. Compositions and methods of making are disclosed. |
| US11420179B2 |
Propulsion element including a catalyzing reactor
A propulsion element including a catalyzing reactor is disclosed. The catalyzing reactor comprises a reactor entrance and a reactor exit and an internal structure arranged for flowing a reacting medium through the reactor from the reactor entrance to the reactor exit. The reactor structure comprising at least one thin walled reactor channel arranged between the entrance and the exit of the reactor. The channel having a channel wall that includes a catalyst and that defines a flow path, in which channel in use, a catalyzed exothermic reaction takes place in the medium as it flows along the flow path. The at least one channel is looped to have a portion of its flow path that is downstream with respect to the reactor entrance in heat exchanging contact with a portion of a flow path that is that is more upstream with respect to the reactor entrance, so as to transfer heat between a downstream portion of the reacting medium to an upstream portion thereof. |
| US11420176B2 |
Chemical reactor with high speed rotary mixing, for catalytic thermal conversion of organic materials into diesel and other liquid fuels, and applications thereof
Chemical reactor with high speed rotary mixing, system thereof, and method thereof, for catalytic thermal conversion of organic (hydrocarbon-containing) materials (coal, plastics, rubber, plant matter, wood shavings, biomass, organic wastes) into diesel and other liquid fuels (automobile or/and jet engine fuels). Relevant to non-conventional commercial scale production of liquid fuels, and to commercial scale processing and disposing of organic waste materials. Chemical reactor includes: integrated combination of a reactor stationary assembly (RSA), having only stationary components remaining stationary during chemical reactor operation, and a reactor rotary mixing assembly (RRMA), having only rotatable components rotating during chemical reactor operation. May include anti-abrasion shield for shielding inner surface of reactor central housing from abrasion during chemical reactor operation. Rotor may include a reinforcement disc. Rotor blades or/and reinforcement disc may include rotor-based performance and process control structural features (openings, or/and protrusions, or/and depressions), for additionally controlling performance of the rotor. |
| US11420174B2 |
Three-dimensional polymer networks with channels situated therein
The disclosure provides three-dimensional crosslinked polymer networks comprising one or more channels extending from the surface and/or near the surface of the network into the interior of the network, arrays comprising the networks, processes for making the networks, and uses of the networks and arrays. |
| US11420171B1 |
Flow bypass device for a vessel containing solid particles
Disclosed is a flow bypass device, a reactor system containing the flow bypass device; a method for operating a fixed bed of solid particles in which gas is re-routed to an interior of the fixed bed, for example, the flow bypass device is used to bypass a portion of the solid particles; and a method for loading solid particles and a flow bypass device into a vessel. The methods and systems can use a single flow bypass device or multiple flow bypass devices that are stacked on top of one another. |
| US11420169B2 |
Apparatus and a method for the preparation of a play, craft and/or toy compound
There is provided an apparatus and a method for producing a play compound and the play compound itself which, in one embodiment is a compound which sufficiently fluid to be pliable and is typically cold and slimy to the touch. The apparatus and a method provide a powder and liquid to a user, which can be a non-skilled person and thereby allow the mixing of the powder and liquid together by that person to form the play compound outside of a factory environment whilst ensuring that the play compound which is formed has the desired characteristics. Most typically the user which performs the mixing can be the end user, such as a child, who will play with the compound and so the formation of the play compound forms a new part of the play experience. |
| US11420167B2 |
Mobile chemical mixing plant
A mobile chemical mixing plant includes an inlet for receiving fluid; a fluid conduit for conveying the fluid from the inlet; a container for containing a chemical therein; a chemical pump for withdrawing the chemical from the container and directing the chemical into the fluid conduit for mixing with the fluid in the fluid conduit to form a chemical mixture; and a homogenization pump for pumping the chemical mixture in the fluid conduit out of the mobile chemical mixing plant. The fluid conduit connects the chemical pump to the homogenization pump. The mobile chemical mixing plant is fixed to a trailer that is attachable to a vehicle. Because the fluid conduit directly connects the chemical pump to the homogenization pump, the mobile chemical mixing plant does not need an intervening mixing tank for mixing the fluid and the chemical. |
| US11420159B2 |
Intensification of biocatalytic gas absorption
Intensification techniques are described for enhancing biocatalytic CO2 absorption operations, and may include the use of a rotating packed bed, a rotating disc reactor, a zig-zag reactor or other reactors that utilize process intensification. Carbonic anhydrase can be deployed in the high intensity reactor free in solution, immobilized with respect to particles that flow with the liquid, and/or immobilized to internals, such as packing, that are fixed within the high intensity reactor. |
| US11420158B2 |
Process and apparatus for alkyl halide fumigant recovery and conversion
Process and apparatus are disclosed for capturing and converting an ozone-depleting alkyl halide fumigant from a fumigant/air mixed stream (14) by absorbing it into a metal hydroxide-alcohol buffer solution (26) in an absorber/scrubber (12) to produce a fumigant-free air stream. The captured alkyl halide in aqueous alcohol solution can actively react with the metal hydroxide in alcohol solution to produce a value-added product, such as a precipitate metal halide, and another alcohol that further enhances absorption. The absorbing solution is well-mixed with make-up alcohol and alkali streams to maintain the concentration of the metal hydroxide in the desired buffer solution range. The solid precipitate metal halide is separated from the liquid stream, and the metal hydroxide-containing mixed alcohol stream is recycled to the absorber/scrubber (12). |
| US11420157B2 |
Automated gas scrubber
An automated system for the separation of vapor and liquid from a gas and liquid combination entering a separation vessel. A programmable logic control unit module controls a valve and is programmed for periodic release of separated liquid collected within the vessel upon achieving various conditions within the vessel or upon expiration of a pre-established time interval, with separated liquid delivered via an outlet port through a valve controlled by the programmable logic control unit to a storage tank. |
| US11420155B2 |
Process of improved sulfur capture from a syngas mixture
A process for sweetening a syngas stream, the process comprising the steps of: providing a syngas stream to a nonselective amine absorption unit, the sour syngas stream comprising syngas, carbon dioxide, and hydrogen sulfide; separating the syngas stream in the nonselective amine absorption unit to obtain an overhead syngas stream and an acid gas stream; introducing the acid gas stream to a membrane separation unit, the acid gas stream comprising hydrogen sulfide and carbon dioxide; separating the acid gas stream in the membrane separation unit to produce a retentate stream and a permeate stream, wherein the retentate stream comprises hydrogen sulfide, wherein the permeate stream comprises carbon dioxide; introducing the retentate stream to a sulfur recovery unit; processing the retentate stream in the sulfur recovery unit to produce a sulfur stream and a tail gas stream, wherein the sulfur stream comprises liquid sulfur. |
| US11420154B2 |
Method of making carbon molecular sieve membranes
The invention is an improved method of making an improved carbon molecular sieve (CMS) membrane in which a precursor polymer (e.g., polyimide) is pyrolyzed at a pyrolysis temperature to form a CMS membrane that is cooled to ambient temperature (about 40° C. or 30° C. to about 20° C.). The CMS membrane is then reheated to a reheating temperature less than the pyrolysis temperature to form the improved CMS membrane. The improved CMS membranes have shown an improved combination of selectivity and permeance as well as stability for separating hydrogen from gas molecules (e.g., methane, ethane, propane, ethylene, propylene, butane, carbon dioxide, nitrogen, butylene, and combinations thereof). |
| US11420153B2 |
Hydrogen sulfide-carbon dioxide membrane separation systems and processes
A process for recovering sulfur from a sour gas is provided. The process includes the steps of: providing the sour gas to a membrane separation unit having a carbon dioxide-selective membrane that comprises a perfluoropolymer, wherein the sour gas comprises carbon dioxide and at least 1 mol % hydrogen sulfide; separating the sour gas using the carbon dioxide-selective membrane in the membrane separation stage to obtain hydrogen sulfide-enriched gas and hydrogen sulfide-stripped gas, wherein the hydrogen sulfide-enriched gas has a hydrogen sulfide concentration of at least 20 mol %, and wherein the hydrogen sulfide-stripped gas comprises carbon dioxide; and processing the hydrogen sulfide-enriched gas in a sulfur recovery unit to obtain sulfur. |
| US11420150B2 |
Aminated magnesium oxide adsorbent and a method of capturing carbon dioxide
An aminated magnesium oxide adsorbent, which is the reaction product of a magnesium oxide matrix having disordered mesopores and an amino silane, wherein amine functional groups are present on an external surface and within the disordered mesopores of the magnesium oxide matrix, and wherein the aminated magnesium oxide adsorbent has an average pore volume of 0.2 to 0.4 cm3/g. A method of making the aminated magnesium oxide adsorbent and a method of capturing CO2 from a gas mixture with the aminated magnesium oxide adsorbent are also described. |
| US11420148B2 |
System for a spray booth
Provided is a system for a spraying booth, including a spraying booth and at least one filter with at least one VOC detector, the system further including a central database where at least data of the VOC detector are stored, whereby is achieved that the value of the measurements can be accessed and controlled centrally, either by the customer's own technicians or by the supplier's technicians, by a communication unit. |
| US11420146B1 |
3D printed environmental control and life support system
An environmental control unit including a particulate filter located within an airstream, the filter created with an additive manufacturing device that creates at least one of randomly sized layering of the filter and randomly oriented layering of the filter to provide for impeding varying sized particulates from passing through the filter. |
| US11420142B2 |
Housing of a liquid separation device for separation of a liquid from a gas-liquid mixture
A housing of a liquid separation device that includes an inlet for the gas-liquid mixture and a set of integrated components, the set of integrated components includes a liquid separator vessel to separate liquid from the gas-liquid mixture, and the liquid separator vessel includes an entry port for the gas-liquid mixture, a liquid outlet port, and a gas outlet port. The set of integrated components includes a set of channels, where a wall of each channel is part of the housing, where the set of channels includes an inlet channel to guide the gas-liquid mixture from the inlet to the entry port and an outlet channel to guide gas from the gas outlet port away from the liquid separator vessel. The housing includes at least two opposite housing pieces which can be hermetically sealed together along a sealing line which is situated in a sealing face. |
| US11420136B2 |
Affinity cell extraction by acoustics
Beads with functionalized material applied to them are exposed to an acoustic field to trap or pass the beads. The beads may include or be free of ferro magnetic material. The beads may be biocompatible or biodegradable for a host. The size of the beads may vary over a range, and/or be heterogenous or homogenous. The composition of the beads may include high, neutral or low acoustic contrast material. The chemistry of the functionalized material may be compatible with existing processes. |
| US11420132B2 |
Robot on which outer skin is mounted
A robot of one aspect includes an outer skin with which a main body is covered. The outer skin includes an engagement portion that engages with the main body by the main body being covered therewith, extended portions that extend from the engagement portion, and attachment members, formed of a hard material, attached to the extended portions so as to extend in a width direction. The outer skin is fixed to the main body by the attachment members being fixed to the main body. |
| US11420126B2 |
Determining hardness quotients for level definition files based on player skill level
A system, a machine-readable storage medium storing instructions, and a computer-implemented method are described herein for a System Tuner for customizing a player's experience. A System Tuner selects a hardness quotient, based on a player skill level, from a hardness quotient range, the player skill level for a player is calculated by a client computing device based at least on a plurality of game moves in a first game level completed by the player. The System Tuner provides the hardness quotient to a level definition file for a second game level. The level definition file modifies at least one feature of the second game level according to the hardness quotient. The System Tuner modifies the hardness quotient range based at least on a performance of the plurality of player's in the second game level and the respective hardness quotients assigned to each of those players for their game play in the second game level. |
| US11420125B2 |
Clustering audience based on expressions captured from different spectators of the audience
Methods and systems for representing emotions of an audience of spectators viewing online gaming of a video game include capturing interaction data from spectators in an audience engaged in watching gameplay of the video game. The captured interaction data is aggregated by clustering the spectators into different groups in accordance to emotions detected from the spectators in the audience. An avatar is generated to represent emotion of each group and expressions of the avatar are dynamically adjusted to match changes in the expressions of the spectators of the respective group. The avatars representing distinct emotions of different group of spectators is presented alongside content of the video game. A size of the avatar for each distinct emotion is influenced by the confidence score associated with the respective group of spectators. |
| US11420124B2 |
Personalized data driven game training system
A video game console, a video game system, and a computer-implemented method are described. Generally, a video game and video game assistance are adapted to a player. For example, a narrative of the video game is personalized to an experience level of the player. Similarly, assistance in interacting with a particular context of the video game is also personalized. The personalization learns from historical interactions of players with the video game and, optionally, other video games. In an example, a deep learning neural network is implemented to generate knowledge from the historical interactions. The personalization is set according to the knowledge. |
| US11420123B2 |
Helper mode in spectated video games
A method is provided, for enabling a spectator of a video game to provide assistance to a player, including: streaming, over a network to a spectator client device operated by a spectator, gameplay video generated from a session of a video game driven by interactive gameplay of a player via a player client device, the gameplay video being rendered by the spectator client device through a spectator interface for viewing by the spectator; during the streaming of the gameplay video, receiving a request from the player client device; responsive to the request, surfacing a notification through the spectator interface, the notification indicating a request for assistance; receiving via the spectator interface, a response to the notification indicating acceptance of the request; responsive to receiving the response, initiating a private communication channel between the spectator client device and the player client device to enable communication between the spectator and the player. |
| US11420122B2 |
Systems and methods for controlling camera perspectives, movements, and displays of video game gameplay
In a multiplayer video game, virtual cameras are controlled by continually assessing and ranking storylines relating to the interactions of various players during a game session. A ranking for each storyline may be based on various factors such as, but not limited to, what the players can see, the distance between certain players, nearby game items or in-game. Subsequently, at least one virtual camera is navigated to provide a view of the highest-ranking storyline, subject to certain limitations on how the camera can move, transition, or otherwise display the interactions between players. In embodiments, a set of rules including rules of cinematography, are used to provide additional control of the movement of the virtual camera. In embodiments, movements of a human camera-person are used on a mocap system to control the movement of the virtual camera. |
| US11420121B2 |
Control program, control method, and computer
A control program causing a computer to execute a competition between two players, based on a correction value obtained by correcting a reference value of at least one player of the two players, the two players respectively belonging to two groups, to store a point which may be determined based on the reference value of at least the one player, in a storage unit in association with a group to which the winning player belongs, and to determine a result of the competition between groups, based on the summation of points which may be stored in the storage unit in association with each group. In a case where a predetermined action is performed on the predetermined game content of the group to which at least the one player belongs, control may be performed to change the correction value of the player and not to change the reference value. |
| US11420119B2 |
Systems and methods for initiating conversion between bounded gameplay sessions and unbounded gameplay sessions
A system and method is provided for continuous gameplay in a multiplayer video game through an unbounded gameplay session. Players may join, exit, and later rejoin a given unbounded gameplay session at any time. A given unbounded gameplay session may therefore continue indefinitely so long as at least one player wishes to continue to gameplay. To facilitate an unbounded gameplay session, the system may score players using time-based or other parameters in a manner that is fair to players who have been playing in the unbounded gameplay session longer than other players. |
| US11420110B2 |
User adaptation system and method
A method of evaluating a videogame for a first user includes: performing a calibration test using a physical input device to evaluate at least a first physical input capability of the first user with respect to that physical input device; evaluating at the at least first physical input capability exhibited with respect to that physical input device during reference play of the videogame by one or reference users other than the first user; comparing the at least first physical input capability exhibited during reference play with that of the first user; and providing an evaluation of the videogame's suitability for play by the first user, based upon the comparison. |
| US11420108B2 |
Systems and methods for using seeds to store outcomes and recreating outcomes using seeds with a random number generator
An electronic gaming machine and a method are provided which generates outcome presentations from a Class 2 or a central determination game outcome. A database stores RNG seeds that correspond to various presentations. To generate the outcome presentations, the RNG seeds are retrieved from the database and random numbers are generated from the RNG seeds. These random numbers are then used to generate the outcome presentations for the Class 2 or central determination game outcome. The RNG seeds may be stored as a series of RNG seeds which may be individually accessed to eliminate certain outcomes or sort certain outcomes prior to presentation. |
| US11420102B2 |
Weighted golf grip
A grip assembly comprising a grip body that extends between an upper butt end and a distal end. The grip body has a topside and a pair of sides that extend from the topside to a rear underside. The grip body defines a bore extending between the upper butt end and the distal end. The rear underside of the grip body defines a surface and a channel in the surface. An outer wrap permanently encases around an entire circumference of the grip body along a portion of a length of the grip body. |
| US11420096B2 |
Visualization of athletic activity
Example embodiments relate to systems, methods, apparatuses, and computer readable media relating to a user interface, that may for example, receive and/or process physical activity data and allow interaction with the received information in novel implementations. |
| US11420094B2 |
Training device for chewing and swallowing
The training device for chewing and swallowing can be used by patients who have difficulty chewing and/or swallowing to assist them to learn how to chew and swallow. The device includes a bolus delivery cylinder and a plunger. The bolus delivery cylinder can include a cylindrical housing having a peripheral wall and a hollow interior. The plunger can be slidably received in the cylindrical housing and secured thereto. In some embodiments the peripheral wall can be perforated. The interior of the housing is configured to accommodate small pieces of food. The bolus delivery cylinder can be made from a transparent, flexible material, such as silicon. |
| US11420092B2 |
Motorized treadmill with motor braking mechanism and methods of operating same
A treadmill includes a frame; a running belt configured to move relative the frame; and a motor coupled to the running belt. The motor is operable in a plurality of user controlled operating modes. In a first operating mode, the force of rotation of the running belt is provided by a user of the treadmill. In a second operating mode, the motor applies a desired braking force to resist rotation of the running belt. In a third operating mode, the motor applies a torque output to the running belt based on a force exerted on the running belt by a user of the treadmill. |
| US11420089B2 |
Power 360
A multifunctional fitness equipment that allows the user to perform a variety of exercises either indoors or outside. The fitness equipment enables the user to perform exercises with the use of weights or their own body weight for resistance and stability. The fitness equipment can be utilized as a sled in which the user can perform cardiovascular conditioning with use of a harness attached to it. In addition, the user can utilize a variety of attachments such as battle ropes, resistance bands, and punching bag to perform a variety of exercises. The fitness equipment is mobile and can also be used by multiple people at the same time. |
| US11420086B1 |
Portable exercise training rig system
A training rig system comprising of equipment callable of folding and collapsing into a compact unit. The compact unit allows the training rig system to be readily portable. |
| US11420082B2 |
Pressure release device
The invention relates to a pressure relief device (1) for a housing (2) which is protected against explosions, in particular is compression-proof and has a wall connecting piece (3) which can be at least partially inserted into a housing opening (4) of a housing wall (6) by its insertion connecting piece section (5), which can be in particular detachably fixed from an inner side of the housing and rests from the outside on an opening edge (8) of the housing opening (4) in its inserted and fixed position with a radially outwardly projecting support flange (7), wherein the insertion connecting piece section (5) furthermore comprises a projecting connecting piece section (9) which is opposite the insertion connecting piece section relative to the support flange (7) and comprises a longitudinal conduit (10) running through the wall connecting piece (3) into which conduit a flame-blocking body (11) is replaceably inserted, wherein a pressure nut (13) which loads the flame blocking body (11) with pressure in its insertion position and with a pressure edge (14) projecting radially inward at least in sections can be screwed onto a free end section (12) of the projecting connecting piece section (9), and wherein the pressure edge (14) contacts an outer viewing side of the flame blocking body (11). |
| US11420081B1 |
Nasal filtration apparatus
A nasal filtration apparatus configured to be releasably secured around a nose of a user and provide filtration of air inhaled therethrough. The present invention includes a body having a wall manufactured from a filtration material or layers thereof such as but not limited to polypropylene. The body includes a central support member extending down the middle thereof from the upper edge to the lower edge of the body. The central support member is malleable so as to permit shaping of the body to form a cavity that will accommodate a user's nose therein. The nasal filtration apparatus includes a perimeter edge that is formed and includes material thereon that provide a releasable securing thereof to the skin of the user. A first nostril insert and second nostril insert can be included to provide additional and/or application specific filtration. |
| US11420079B2 |
In-mask feedback system
Disclosed herein is an in-mask display or feedback system having a lens coupled to a face blank of the mask, the lens covering a facepiece. The feedback system includes a display apparatus coupled to the facepiece, and disposed within an interior of the mask, the display apparatus being powered by a first power source coupled to a housing of the display apparatus. The feedback system further includes a recording device (e.g., a camera) coupled to the face blank, the recording device operable to communicate data (e.g., wirelessly or wired) with the display apparatus. In some approaches, the recording device is powered by a second power source. In other approaches, the first power source provides power to both the recording device and the display apparatus. In another approach, the display apparatus includes an adjustment aperture formed therethrough to allow adjustment of an eye piece housing a display. |
| US11420077B2 |
Radiation detector calibration
A computer program product, method, system and device that acquires, by a radiation detector, exit radiation measurement information during delivery of patient treatment. Patient anatomy information is also received and a radiation detector response calibration is determined utilizing at least the exit radiation measurement information, the patient anatomy information, and at least a portion of a radiation treatment plan. |
| US11420076B2 |
Utilization of a transportable CT-scanner for radiotherapy procedures
The present application relates to a data processing method for determining the position of a soft tissue body part within a patient's body. The data processing method includes acquiring CT-image data including information about the position of the body part within a coordinate system assigned to a transportable CT-device, wherein the patient's body is positioned relative to the treatment device, and wherein the CT-device is configured to be positioned relative to the patient's body and/or relative to the treatment device, acquiring first transformation data including information about a first transformation between the coordinate system assigned to the CT-device and a coordinate system assigned to the treatment device, and determining, based on the CT-image data and the first transformation data, position data including information about the position of the body part within the coordinate system assigned to the treatment device. |
| US11420073B2 |
Method of treatment of eyelid laxity
A method of treating eyelid laxity in a subject comprising exposing a tarsal plate of an eye, and applying to at least part of the exposed tarsal plate a photosensitizer that initiates crosslinking in response to photo-activating radiation; and irradiating the exposed tarsal plate with photo-activating radiation to initiate crosslinking in the tarsal plate tissue. |
| US11420072B2 |
Method for increasing blood flow and metabolic rate of eye fundus
A method for increasing the blood flow and metabolic rate of the eye fundus by (1) irradiating the eye fundus through the pupil by using red light or near-infrared light in a certain wavelength range, a certain energy density range and a certain irradiation time range; (2) once irradiation is complete, repeating the irradiating at intervals of a certain time range, using red light or near-infrared light in the same wavelength range and the same energy density range to irradiate the eye fundus through the pupil. |
| US11420069B2 |
Implantable medical devices, and methods of use therewith, that detect MRI systems with enhanced specificity
Embodiments describe herein generally pertain to implantable medical device (IMDs), and methods for use therewith, that can be used to automatically switch an IMD from its normal operational mode to an MRI safe mode, and vice versa, within increased specificity. In certain embodiments, a controller of the IMD uses a magnetic field sensor to determine whether a first magnetic field condition is detected, and uses an accelerometer to determine whether a positional condition is detected. In response to the first magnetic field condition being detected, and the positional condition being detected, the controller can use the magnetic field sensor to determine whether a second magnetic field condition is detected, which differs from the first magnetic field condition. The controller can then cause the IMD to enter the MRI safe mode based at least in part on the first and second magnetic field conditions and the positional condition being detected. |
| US11420067B2 |
Medical device and method for controlling pacing interval to promote mechanical heart chamber synchrony
A medical device includes a motion sensor for producing a motion signal including cardiac event signals. The medical device generates a ventricular pacing pulse upon expiration of a pacing interval. The medical device determines a synchrony metric from the motion signal after a delivered ventricular pacing pulse and adjusts the pacing interval based on the synchrony metric. |
| US11420066B2 |
Delivery of independent interleaved programs to produce higher-frequency electrical stimulation therapy
The techniques of the disclosure describe example medical devices, systems, and methods for interleaving a plurality of low-frequency electrical stimulation pulse trains delivered by a plurality of sets of electrodes of an implantable medical device (IMD) to effectively deliver a combined high-frequency electrical pulse train to a target tissue area. In one example, each set of the plurality of sets of electrodes has a unique anode and cathode. In another example, a clinician adjusts the size or shape of the target tissue area receiving the combined high-frequency electrical pulse train by selecting different combinations of the plurality of sets of electrodes. |
| US11420064B2 |
Method and apparatus for application of a neural stimulus
A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked. |
| US11420060B2 |
Method for treating episodes of apnoea and/or hypopnea and system for detecting said episodes
A method for treating episodes of apnoea and/or hypopnea is provided. The method has the steps of: a) detecting or predicting an episode of apnoea and/or hypopnea by means of at least one sensor selected from a respiratory pressure sensor, a pulse oximeter, an acoustic sensor and/or a respiratory temperature sensor; and b) emitting an electrical signal by means of an electrical actuator connected to at least one submental nerve and/or muscle, the electrical signal having a bipolar waveform and a frequency between 5 and 100 Hz. |
| US11420057B2 |
Systems and methods to place one or more leads in tissue for providing functional and/or therapeutic stimulation
Systems and methods make possible the placement of one or more electrode leads in a tissue region for providing functional and/or therapeutic stimulation to tissue. The systems and methods are adapted to provide the relief of pain. |
| US11420051B2 |
Medical device for treating diabetes
A medical device containing a sensor, a motor, one or more plates, and a control unit, for treating diabetes. The medical device vibrates the pancreas thereby improving blood and secretory hormone circulation and enhancing the production of insulin. |
| US11420049B2 |
Systems for administering electrical stimulation to treat cancer
Embodiments herein relate to a medical device for treating a cancerous tumor, including an electric field generating circuit configured to generate one or more electric fields at or near a site of the cancerous tumor and control circuitry in communication with the electric field generating circuit. The medical device includes one or more supply wires in electrical communication with the electric field generating circuit and one or more supply electrodes. The supply electrodes are configured to deliver an electric field at or near the site of the cancerous tumor. The medical device can include one or more sensing wires in electrical communication with the control circuitry and one or more sensing electrodes. The sensing electrodes can be configured to measure an impedance of the cancerous tumor at at least two different electric field strengths. Other embodiments are also included herein. |
| US11420047B2 |
Wireless patch system for transdermal, transmucosal and dental electrical drug delivery
Methods and systems for delivering drug particles to a target site are disclosed. An example method for implementing the subject matter described herein includes applying a drug delivery patch to a target site. The drug delivery patch can include a substrate, an electrode integrated with the substrate, and a fluid in the substrate having drug particles suspended in the fluid. The method further includes transmitting a signal to the drug delivery patch to power the drug delivery patch by inductive coupling. Powering the drug delivery patch causes the electrode in the drug delivery patch to motivate the drug particles towards a target site of the drug delivery patch. |
| US11420044B2 |
Aortopulmonary electrical stimulator-pressure transducer
In an embodiment herein, an aortopulmonary stimulation method is provided including positioning at least one aortic electrode in or near the aorta, and using the at least one aortic electrode, to deliver stimulation to the aorta to decrease aortic after load. |
| US11420043B2 |
Low-frequency treatment device, body for low-frequency treatment device, and combination of pad and holder for low-frequency treatment device
A low-frequency treatment device includes a pad including a through hole and a pad side electrode on a rear surface, a holder disposed on the rear surface side of the pad so as to oppose the pad side electrode, a body including a body side electrode and detachably attached to the holder, and a wiring member configured to electrically connect the body side electrode and the pad side electrode. The wiring member includes a first end portion connected to the body side electrode, a second end portion connected to the pad side electrode, and a conductive portion, disposed such that a portion of the conductive portion extends through a through hole, for conducting electricity between the first end portion and the second end portion. |
| US11420033B2 |
Low-profile single and dual vascular access device
A low-profile access port for subcutaneous implantation within a patient is disclosed. The access port includes a receiving cup that provides a relatively large subcutaneous target to enable catheter-bearing needle access to the port without difficulty. In one embodiment, a low-profile access port comprises a body including a conduit with an inlet port at a proximal end, and a receiving cup. The receiving cup is funnel shaped to direct a catheter-bearing needle into the conduit via the inlet port. The conduit is defined by the body and extends from the inlet port to an outlet defined by a stem. A bend in the conduit enables catheter advancement past the bend while preventing needle advancement. A valve/seal assembly is also disposed in the conduit and enables passage of the catheter therethrough while preventing fluid backflow. The body includes radiopaque indicia configured to enable identification of the access port via x-ray imaging. |
| US11420026B2 |
Expandable sheath
A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen. |
| US11420024B2 |
Drainage tubing management device
A drainage tubing management device is provided. The drainage tubing management device generally comprises a body including a planar field, and having plural pairs of spaced-apart protrusions extending from said field, each pair of protrusions sized to accept flexible drainage tubing therebetween, wherein pairs of the protrusions are arranged in at least first and second rows such that drainage tubing may be retained with respect to said body along the first and second rows, at least one aperture in said body, and a securement mechanism comprising one or more of (a) a post having a longitudinal axis, said post being insertable through within said aperture and having a terminal flange occluding passage of said post through said aperture, said post being sufficiently rigid to support said body and (b) a flexible hanging strap insertable through said aperture and having a terminal flange occluding passage of said strap through said aperture. |
| US11420022B2 |
Actuating elements for bending medical devices
A medical device includes: an elongated tube having a wall defining a lumen for the elongated tube, wherein the wall of the elongated tube comprises a first opening; and a first actuating element coupled directly or indirectly to the wall of the elongated tube; wherein at least a part of the first actuating element and the first opening of the wall are located at a same longitudinal position with respect to a longitudinal axis of the elongated tube; and wherein the first actuating element is configured to change size to induce stress and/or displacement at the wall of the elongated tube to cause the elongated tube to bend. |
| US11420021B2 |
Fluid-actuated displacement for catheters, continuum manipulators, and other uses
Catheter-supported therapeutic and diagnostic tools can be introduced into a patient body with a sheath slidably disposed over the tool. Once the tool is aligned with a target tissue, a first fluid-driven actuator can move the sheath axially from over the tool, for example, to allow a stent, stent-graft, prosthetic valve, or other self-expanding tool, to expand radially within the cardiovascular system, without having to transmit large deployment forces along the catheter shaft and sheath from outside the patient. A second fluid-driven actuator can be arranged in opposition to the first actuator to control release of the expanding tool or to recapture the tool within the sheath. The first and/or second actuators may comprise a balloon having a diameter larger than the sheath to provide the desired deployment and recapture forces with moderate fluid pressure. |
| US11420020B2 |
Medical device including a variable torque assembly for device deflection
The present disclosure provides a medical device comprising a deflecting assembly configured to assist in deflecting a distal portion of a catheter shaft. The deflecting assembly may include a first rotatable member having a first diameter and a first pull wire coupled thereto and a second rotatable member having a second diameter smaller than the first diameter and a second pull wire coupled thereto, wherein the second rotatable member is coupled to the first rotatable member such that a center point of the second rotatable member is offset from a center point of the first rotatable member. The first and second rotatable members are configured such that rotation of the first rotatable member via the first pull wire causes rotation of the second rotatable member and second pull wire, thus resulting in deflection of a distal portion of the medical device. |
| US11420016B2 |
Gel distributor in urinary catheter package
A package or container for a catheter having a catheter tube with a proximal end provided with a catheter outlet and a distal opening at a distal end thereof. A gel receptacle is provided with a cavity for holding an amount of a lubricating agent, and the catheter tube extends therethrough. The gel receptacle is configured such that as the catheter is withdrawn from a stored position therein, a leading tip of the catheter is immersed in the lubricating agent, thus automatically coating the leading tip. The gel receptacle may be held within a rigid body or may be a standalone item packaged in a sterile bag solely with the catheter. A side wall of the gel receptacle is deformable so that as the catheter is withdrawn proximally the side wall is collapsed inward to displace the lubricating agent gel and coat an exterior surface of the catheter tube. |
| US11420014B2 |
Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion
Ureteral catheters and assemblies are provided including: a drainage lumen including a proximal portion configured to be positioned in at least a portion of a patient's urethra and a distal portion configured to be positioned in a patient's ureter and/or kidney, the distal portion including a coiled retention portion including at least a first coil having a first diameter and a second coil having a second diameter, the first diameter being less than the second diameter; or wherein the retention portion extends radially outwardly from a portion of the distal end of the drainage lumen portion, the retention portion including a proximal end having a first diameter, a distal end having a second diameter, and a wall and/or surface extending therebetween, the retention portion having a second diameter is greater than the first diameter when deployed; or wherein the retention portion includes a plurality of drainage tubes. |
| US11420012B2 |
Audio tone programmed hygienic and therapeutic sleep and wake eye mask having remotely controlled sunrise and sunset multimodes
An eye mask for use to wake up and/or to go to sleep provides ease of cleaning or replacement without damaging electrical or optical components; different user selectable sunrise and sunset illumination modes respectively having blue-shifted and red-shifted spectra simulating natural sunrises and sunsets to assimilate the sleep/wake cycle to the natural rhythms of day and night; sunset and/or sunrise illumination modes that oscillate with fixed period or sequentially changing periods that correspond to brainwave frequencies that respectively facilitate going to sleep and/or waking and synergistically co-operate with corresponding sunset or sunrise light fields to help the user to fall into restful sleep or to awake refreshed and alert; and audio tone programming of illumination mode and treatment time and/or duration of therapy by a remote tone control generator. |
| US11420010B1 |
Bag and valve for advanced respiratory support
A respiratory device provides respiratory support to a patient. The respiratory device includes an expandable bag and a rigid valve housing. The expandable bag has an air inlet valve as well as a first and second sides that are bounded, respectively, by first and second rigid side panels. Each of the first and second rigid side panels includes a biasing member projection. The rigid valve housing is in fluid communication with the expandable bag. The rigid valve housing includes an adjustable tidal volume control device that interfaces with the biasing member projection of each of the first and second rigid side panels to set one of a plurality of predetermined tidal volumes for the expandable bag in an uncompressed or compressed configuration. The rigid valve housing additionally includes a patient breathing interface connection member. |
| US11420009B2 |
Valve with internal member
A valve with an internal member is disclosed which allows exhaled carbon dioxide to escape from a breathing circuit when the circuit gas pressure drops below a threshold pressure. The valve operates by occluding one or more ports under a relatively high pressure and opening the one or more ports under a relatively low pressure. The internal member is attached to the body of the valve at two or more locations on the internal member. The internal member moves in a direction perpendicular to the gas flow through the valve. |
| US11420007B2 |
Flow triggered gas delivery
A fluid delivery system provides fluid, such as supplement oxygen, to a patient in response to inhalation. The fluid delivery system includes a valve assembly that is triggered by sensing onset of inspiration by measuring a change in temperature of air flow in a nasal or oral cannula, mask or helmet. |
| US11420000B2 |
Magnetically assisted sealing arrangement for a patient interface device
A sealing arrangement (20) for use in a patient interface device (18). The assembly includes a flexible member (30) having a sealing surface (30A) structured to engage a surface of the patient at or about the airway, a first magnetic material disposed in or on the flexible member, and a second magnetic material (36) positioned in one or more of a carrier member structured to be removably positioned on, in, or about the patient, and a portion of the patient interface device. The first and second magnetic materials are positioned and structured to magnetically interact in a manner which urges the sealing surface toward the surface of the patient when the flexible member is disposed at or about the airway and the second magnetic material is disposed at a corresponding position. |
| US11419993B2 |
Inhalator and inhalator set
Inhalator comprising an aerosol generator configured to generate an aerosol by nebulizing a fluid and a controller configured to control operation of the aerosol generator and a housing accommodating at least the aerosol generator and the controller, the housing having a base for supporting the housing on a horizontal surface, wherein a portion of the housing accommodating at least a portion of the controller is arranged further away from the base than the aerosol generator as seen in a vertical direction, when the base is supported on the horizontal surface. |
| US11419987B2 |
Multiple dose device and method
A multiple dose syringe has a first valve defining a first valve opening pressure and a second valve defining a second valve opening pressure. A storage chamber in fluid communication with the second valve stores multiple doses of a substance therein and includes an outlet for dispensing multiple doses of the stored substance therethrough. A compression surface is movable between first and second positions and defines a compression chamber between the compression surface and the first valve. Movement of the compression surface in a direction from the first position toward the second position dispenses substance in the compression chamber through the first valve and out of the syringe. Movement of the compression surface in a direction from the second position toward the first position causes substance to flow from the storage chamber through the second valve and into the compression chamber. |
| US11419986B2 |
Supplemental device for attachment to an injection device
A supplemental device for attachment to an injection device, the supplemental device comprising: a housing; an electromechanical switch arrangement having an open state and a closed state, the electromechanical switch arrangement comprising a protrusion configured to contact a surface of the injection device while the supplemental device is attached to the injection device; a dose dialled detector operable to detect a dose of medicament dialled into the attached injection device; and a processor arrangement configured to: monitor the detected dose of medicament dialled into the attached injection device; detect a change in the state of the electromechanical switch arrangement; and change a display output of the supplemental device when a change in the state of the electromechanical switch arrangement is detected while a zero dose is dialled into the attached injection device. |
| US11419982B2 |
Dripping detection apparatus
A dripping detection apparatus includes a cylindrical drip cylinder into which a nozzle is inserted from an upper side and that receives inside a liquid droplet dripping from a lower end of the nozzle, and a photo interrupter that has equal to or more than one light emitting element emitting light and equal to or more than two light receiving elements receiving the light, wherein the equal to or more than one light emitting element and the equal to or more than two light receiving elements are arranged at opposing or substantially opposing positions with the drip cylinder interposed between the elements and equal to or more than two light paths connecting the equal to or more than one light emitting element to the equal to or more than two light receiving elements are located at a lower side relative to the lower end of the nozzle. |
| US11419980B2 |
Bolus refill indicator
A drug administration device including a push button, plunger, housing extending in an axial direction to define top and bottom ends, and bolus refill indicator is provided. The indicator is disposed on the plunger and visible through a window in the housing. The indicator can include a first section having a first color located towards the top end of the housing, a second section having a second color located towards the bottom end of the housing, and a third section disposed therebetween including a gradient between the first and second colors. Alternatively, the indicator can include a line extending in a direction perpendicular to the axial direction. The housing includes a first indicator reference point that is a first color and aligned with a bottom of the indicator window and a second indicator reference point that is a second color and aligned with a top of the indicator window. |
| US11419979B2 |
Variable fluid flow rate control device
A flow selector having features for controlling the flow rate of a fluid over a continuous range of flow rates is provided. In particular, a flow selector including a flow rate selection mechanism is provided, where the flow rate selection mechanism provides more precise control of the fluid flow rate. A flow selector comprising a needle valve for controlling the flow rate of a fluid over a continuous range of flow rates also is provided. |
| US11419978B2 |
Subcutaneous access hub with multiple cannula ports
Subcutaneous access hub embodiments are discussed herein that include housing embodiments having a plurality of cannula ports and a fluid passageway network that allows fluid communication between a fluid source and the plurality of cannula access ports. Such a configuration may allow a user such as a patient or clinician to releasably secure the housing to an outside surface of the patient's skin. Multiple locations on the patient's skin may then be accessed for deployment of one or more delivery cannulas via a plurality of cannula ports for delivery of fluid and from the fluid source to multiple subcutaneous locations below the patient's skin and timely movement of cannula access in the patient's skin without the need for relocating the housing. |
| US11419971B2 |
Ocular surgical work tip adapter
An adapter for a surgical hand piece with a single lumen work tip converts the handpiece to infusion/aspiration (I/A) cleanup of lens epithelial cells in the capsular bag of the eye a patient after phacoemulsification. The adapter is in the form of a sleeve whose proximal end is to be joined to the distal end of work tip. The sleeve also has at least one aspiration hole located toward the distal end of the sleeve. |
| US11419967B2 |
System and method to efficiently clean a blood filter
A renal therapy apparatus includes a blood filter, a blood pump, a treatment fluid pump, and a control unit configured to control at least one of the blood pump or the treatment fluid pump during a filter cleaning sequence. The blood filter includes a plurality of hollow fiber membranes. During the filter cleaning sequence, a fluid mixture is formed by mixing air with a blood-compatible and physiologically safe fluid. Also during the filter cleaning sequence, the fluid mixture is transferred across insides and/or outsides of the plurality of hollow fiber membranes at least one time. The use of the fluid mixture enables the filter cleaning sequence to be performed during the blood treatment. |
| US11419966B2 |
Virtual patient donation
A system includes a device having a blood side, a solution side, and a semipermeable membrane structurally configured for diffusion of one or more solutes therethrough. The system also includes a first extracorporeal circuit having one or more first fluid connectors for connecting the blood side of the device to the vascular system of a first animal, a second extracorporeal circuit including one or more second fluid connectors for connecting the solution side of the device to the vascular system of a second animal, a first pump in fluid communication with at least one of the first and second extracorporeal circuits, and a driver mechanically coupled to the first pump, the driver configured to drive the first pump using energy from an energy source. |
| US11419962B2 |
Spheroids including biologically-relevant materials and related methods
A method of making a spheroid is provided that includes the step of providing a suspension having one or more biologically-relevant materials dispersed within a biocompatible medium. An amount of a hydrophilic material is deposited on a defined area of a super-hydrophobic surface, and a droplet of the suspension is bioprinted onto the hydrophilic material positioned on the super-hydrophobic to thereby create the spheroid. |
| US11419957B2 |
Automated device for production of bioengineered tissues and organs based on decellularization and recellularization
The present invention discloses an automated device for tissue and organ engineering. The device comprises a main chamber for performing decellularization, tissue sterilization, and recellularization and a set of solution and medium chambers, which provide solutions and medium for the decellularization and recellularization processes, respectively, in a continuous closed circuit. The device further comprises a sterilizing system for self-sterilization of the automated device. The device further comprises a user interface to input steps of protocols for tissue or organ engineering. The device further comprises a controller configured to control valves and pumps, which control and direct the flow of solutions and medium based on the steps of protocols, thereby automating the processes of decellularization, tissue sterilization, recellularization and self-sterilization. All parts of the device are installed in one single body in a fully integrated manner, in one example, which makes the device ready to use. The device minimizes the user intervention and enhances sterility, reproducibility, and efficiency. |
| US11419949B2 |
Adeno-associated virus variant capsids and methods of use thereof
Provided herein are variant adeno-associated virus (AAV) capsid proteins having one or more modifications in amino acid sequence relative to a parental AAV capsid protein, which, when present in an AAV virion, confer increased infectivity of one or more types of retinal cells as compared to the infectivity of the retinal cells by an AAV virion comprising the unmodified parental AAV capsid protein. Also provided are recombinant AAV virions and pharmaceutical compositions thereof comprising a variant AAV capsid protein as described herein, methods of making these rAAV capsid proteins and virions, and methods for using these rAAV capsid proteins and virions in research and in clinical practice, for example in, e.g., the delivery of nucleic acid sequences to one or more cells of the retina for the treatment of retinal disorders and diseases. |
| US11419947B2 |
Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes. |
| US11419944B2 |
Non-linear self-immolative linkers and conjugates thereof
The present invention relates to linker-drug compounds (LDs) and antibody-drug conjugates (ADCs) comprising a non-linear self-immolative linker, which is cleavable or transformable under appropriate conditions and which reduces the hydrophobicity of the antibody-drug conjugate. |
| US11419940B2 |
Composition as auxiliary means for oral medication
Compositions, specifically a jelly, are provided the use of which composition as an auxiliary means eases the taking of oral medication in solid form, which composition comprises iota-carrageenan as a jellifying agent and citric acid as a salivating agent, characterized in that the composition further comprises maltodextrin. In another aspect, the composition comprises a calcium sequestrant for adjusting Ca-ion activity of the composition. In one embodiment, the composition comprises iota-carrageenan in 0.7-1.0% in mass, citric acid in 0.06-0.07% in mass, maltodextrin in 1.5% in mass, all relative to the total mass of the composition, and an amount of a calcium sequestrant such that the Ca-ion activity of the composition is between 20 ppm and 80 ppm. |
| US11419937B2 |
Delivery of nanoparticles
Delivery of compositions for treatment of skin tissue with photoactive plasmonic nanoparticles and light, with embodiments relating to delivery devices. Treatments are useful for cosmetic, diagnostic and therapeutic applications. |
| US11419934B2 |
Use of VDAS to enhance immunomodulating therapies against tumors
Methods for producing an anti-tumor effect in a subject suffering from a cancer or a tumor are disclosed. The methods comprise administering to the patient a Vascular Disrupting Agent (VDA) that a combretastatin agent and one or more antibodies selected from the group consisting of: a CTLA-4 antibody, a PD-1 antibody, a PD-L1 antibody, and a PD-L2 antibody in amounts effective therefor. Examples of combretastatin include CA1P, CA4P, and their corresponding salts and prodrugs. The combination of the VDA and one or more of the antibodies produced a synergistic anti-tumor effect. |
| US11419927B2 |
Vaccine in combination with an immune checkpoint inhibitor for use in treating cancer
A polypeptide for use in medicine is provided. The polypeptide is administered simultaneously, separately or sequentially with an immune checkpoint inhibitor. The polypeptide comprises at least one polypeptide comprising a region of at least 12 amino acids of a self-antigen or a sequence having at least 80% identity to the region. The polypeptide is less than 100 amino acids in length. |
| US11419923B2 |
Self-assembling synthetic proteins
The present disclosure provides for a synthetic immunogenic protein for use as an immuno-modulatory agent to enhance mammalian immune reactions towards conjugated protein or peptide containing antigens that are otherwise poorly immunogenic, including but not limited to self-antigens. The chimeric immunogenic proteins of the present disclosure can be used in the treatment of many illnesses, including but not limited to cancers, infectious disease, autoimmune disease, allergies and any clinical indication involving or affected by the immune response of a mammalian host. |
| US11419921B2 |
Methods of treating neurological disorders
Disclosed is a method for treating a subject having a neurological disorder characterized by the presence of dipeptide repeat proteins comprising contacting the cerebrospinal fluid (CSF) of the subject with an agent capable of removing or degrading the toxic protein. |
| US11419920B2 |
Factor VIII sequences
There is provided a nucleic acid molecule comprising a nucleotide sequence encoding a Factor VIII protein, wherein a B domain portion of the Factor VIII protein is encoded by a nucleotide sequence between 90 and 111 nucleotides in length and has an amino acid sequence that is at least 85% identical to SEQ ID NO: 4 which comprises six asparagine residues. Also provided is a Factor VIII protein, a vector comprising the above nucleic acid molecule, a host cell, a transgenic animal, a method of treating Haemophilia for example, Haemophilia A, and a method for the preparation of a parvoviral gene delivery vector. |
| US11419918B2 |
Treatment of biliary cirrhosis based on oxyntomodulin analogue GLP-1R/GCGR dual-target agonist peptide
The invention relates to uses of polypeptide compounds having dual target agonist effect on glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR), characterized by high enzymolysis stability, high biological activity and no adverse reaction. The polypeptide compounds are able to significantly improve a degree of BDL-induced cholestasis hepatic fibrosis in rats, and have significant therapeutic effects on diseases such as biliary cirrhosis. The dual target agonist polypeptides are applicable to the prevention or treatment of biliary cirrhosis and related hepatic fibrosis diseases. |
| US11419916B2 |
Methods and compositions for inducing differentiation of human brown adipocyte progenitors
This disclosure relates to compositions and methods for recruiting brown adipocytes in vitro and in vivo from brown adipocyte progenitor cells found in human skeletal muscle. Methods for treating metabolic disease are also provided. Additionally, methods for treating hypothermia are provided. In some embodiments, the brown adipocyte recruiter is a human protein or peptide. In other embodiments the brown adipocyte recruiter may be a non-human protein or peptide. In still other embodiments, the brown adipocyte recruiter is a small molecule or natural product. |
| US11419915B2 |
Compositions and methods for the treatment of malnutrition
The present invention relates to novel liquid or semi-liquid nutritional compositions, and powders to generate such liquid or semi-liquid nutritional compositions, that are beneficial in the treatment of malnutrition and malnutrition-related disorders such as weight loss and muscle wasting. When administered regularly, the nutritional compositions according to the present invention contribute to the reversal of malnutrition and malnutrition-related disorders such as weight loss and/or muscle atrophy. |
| US11419905B2 |
Bacteroides ovatus for relieving endotoxin infection and application thereof
The disclosure discloses Bacteroides ovatus for relieving endotoxin infection and application thereof, and belongs to the technical field of microorganisms. The Bacteroides ovatus CCFM1021 of the disclosure has low immunogenicity, and can reduce the content of pro-inflammatory factors and increase the concentration of anti-inflammatory factors in the blood of mice infected with endotoxin, up-regulate the number of Foxp3+ regulatory T cells and stabilize the composition of the intestinal microbiota. A pharmaceutical composition of the Bacteroides ovatus CCFM1021 for relieving endotoxin infection has broad application prospects. |
| US11419903B2 |
Method and system for reducing the likelihood of osteoporosis
Various embodiments of the present invention are directed to the field of treating and preventing osteoporosis, with particular embodiments directed to a method of ameliorating, treating, or preventing osteoporosis in a human subject employing tomatidine, xylitol, rapamycin, etc., as well as modifying an individual's microbiome to reduce the likelihood of osteoporosis. |
| US11419900B2 |
Methods and compositions for the treatment of C. difficile
Disclosed herein are compositions and methods for preventing, ameliorating, or treating Clostridium difficile infections and/or reducing the severity of one or more risk factors, signs, or symptoms associated with C. difficile infections. In particular, the technology of the present disclosure relates to methods for administering an effective amount of a composition comprising strains of Bacillus amyloliquefaciens bacteria identified as ART24, ART4, and ART 12, to a subject suffering from or at risk for C. difficile infections. |
| US11419899B2 |
Method of treating aortic aneurysm using muse cells
A cell product for prevention and/or treatment of vascular disorders such as aortic aneurysm, comprising a SSEA-3-positive pluripotent stem cell derived from a mesenchymal tissue in a living body or a cultured mesenchymal cell (Muse cell). |
| US11419898B2 |
Combinatorial cancer immunotherapy
Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer. |
| US11419897B2 |
Engraftment of stem cells with a combination of an agent that targets stem cells and modulation of immunoregulatory signaling
The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche. In particular, the present invention combines the use of selective ablation of endogenous stem cells with a combination of antibodies specific for CD117, and agents that modulate immunoregulatory signaling pathways, e.g. agonists of immune costimulatory molecules, in combination with the administration to the recipient of exogenous stem cells, resulting in efficient, long-term engraftment, even in immunocompetent recipients. |
| US11419895B2 |
Compositions and methods of cellular immunotherapy
Disclosed herein are methods of treating a subject exhibiting a cell that expresses Wilms tumor protein 1 (WT1). The methods typically utilize anti-WT1 antigen binding units or chimeric antigen receptor immunoresponsive cells to a subject in need thereof to effect killing of tumor cells. |
| US11419892B2 |
Antimicrobial platelet-like particles
Disclosed herein are platelet-like particles incorporating antimicrobial metallic nanoparticles. The platelet-like particles include an ultra-low crosslinked polymeric microgel and fibrin targeting moiety. The antimicrobial metallic nanoparticles can be covalently or noncovalently incorporated into the platelet-like particles. The particles are useful to stop bleeding and to promote wound healing while at the same time suppressing bacterial infections that can accompany tissue damage. |
| US11419889B2 |
Oral compositions for post-dental implants
Oral compositions generally, but not exclusively, used for post dental implants that provide low abrasiveness and improved sanitization and protection of dental implants as well as facilitation of tissue regeneration with better active stability and compatibility as well as synergistic effects are described. The oral compositions include one or more mucus regenerators, one or more antiseptic agents, and one or more orally acceptable carrier actives selected from a group of one or more thickeners, one or more humectants, one or more sweeteners, a preservative, one or more surfactants, a film forming agent, a thixotropic agent, a solubilizing agent, a chelating agent, a coloring agent, an anti-tartar agent, an abrasive, an antioxidant agent, a flavoring agent, and a water vehicle, or mixtures thereof. |
| US11419888B2 |
Composition and method for promoting reduction of heat stress in animals
Disclosed herein is a method for promoting reduction of heat stress in animals, as well as a composition for use in the disclosed method. The composition comprises a glucan, silica, mineral clay, mannan, and optionally an endoglucanohydrolase, and may be administered to an animal that is susceptible to or suffers from heat stress. |
| US11419886B2 |
Formulations and methods for treating conditions of the eye
The present disclosure relates to methods of treating chronic conditions of the eye, such as dry eye disease and blepharitis, as well as to methods for increasing secretion of meibum. This disclosure also relates to formulations suitable for treating chronic conditions of the eye such as dry eye disease and blepharitis. |
| US11419880B2 |
Ursodeoxycholic acid-containing agent for treating or preventing presbyopia
The present disclosure provides an agent for treating or preventing eye diseases such as presbyopia, comprising, as an active ingredient, ursodeoxycholic acid or an amide conjugate of ursodeoxycholic acid, or an ester thereof, or a pharmaceutically acceptable salt thereof. |
| US11419867B2 |
Bupropion as a modulator of drug activity
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan. |
| US11419864B2 |
Markers of tissue aging and uses therefor
Provided herein are methods of detecting or determining aging and/or oxidative damage in tissue, including placental tissue, skin, kidney and brain tissue. One embodiment provides a method for detecting or determining aging in body tissue, comprising measuring one or more markers of aldehyde oxidase 1 (AOX1) expression or activity in a biological sample, wherein the level of AOX1 expression or activity, or of the one or more markers, is indicative of aging in the tissue. Also provided herein are methods of treating a disease or condition associated with ageing or oxidative damage in one or more cells or tissues, comprising administering to a subject in need thereof an inhibitor of AOX1. |
| US11419862B2 |
Quinoline derivative for treatment of nasopharyngeal carcinoma
The present invention provides a quinoline derivative for the treatment of nasopharyngeal carcinoma and use thereof in preparation of a pharmaceutical composition for tumor treatment. |
| US11419858B2 |
Composition and methods for treating heritable pulmonary artery hypertension associated with nonsense mutations
The present disclosure relates generally to compositions and methods for treating, preventing, or slowing the rate of development of a disease or condition mediated by a nonsense mutation in the bone morphogenetic protein receptor type II (Bmpr2) in a subject in need thereof. The method entails administering to the subject a compound of the present disclosure, such as GJ103 and a salt thereof. |
| US11419852B2 |
Beta-lactam compounds or salts thereof for use in long-acting prevention or treatment of a glucose metabolism disorder
Provided is a long-acting method for preventing or treating glucose metabolism disorders that includes administering a beta-lactam compound or a pharmaceutically acceptable salt thereof to a subject in need thereof. The method for preventing or treating glucose metabolism disorders has a long-acting effect that lasts more than two days even after medication has been stopped. |
| US11419848B2 |
Combination of unsaponifiable lipids combined with polyphenols and/or catechins for the protection, treatment and repair of cartilage in joints of humans and animals
The present invention relates to a composition for the protection, treatment and repair of cartilage in humans and animal joints. The composition contains a combination of unsaponifiable lipids together with one or more of polyphenols and/or catechins. The composition or kit may contain avocado:soybean unsaponifiables (ASU) and green tea. |
| US11419846B2 |
Blended cannabis compounds and methods of making the same
Blended, processed marijuana and/or hemp cannabis com-pounds and methods of making the same are provided. In particular, the compound includes one or more species of cannabis mixed in various ways with other ingredients in order to produce a new matter, food product, oil, or drink, in the form of gummies, creams, salves, tablets, capsules, pastes, gelatin suppositories, crystals, ointments, jellies, e-juices, powders, pills, syrups, drops, patches, chewing gums, dried whole or partial plant parts, and dusts, such that it is safe for mammals and provides assistance in dealing with various ailments and diseases. |
| US11419843B2 |
Small molecule BCL-2 functional converters as cancer therapeutics
Methods for inducing growth inhibition or apoptosis of Bcl-2-expressing cells and treatments of Bcl-2 expressing cancers are provided. Additionally, assays for agents that can induce apoptosis of Bcl-2 expressing cells are disclosed. |
| US11419841B2 |
Uses of lipophenolic compounds
The present invention relates to compound of formula (I): wherein R is O—R3 or R1 and R2 are identical or different and are each independently H, (C1-C6)alkyl, —CO—(C1-C21)alkyl or —CO—(C11-C21)alkenyl group, provided that at least one of R1 or R2 is H or (C1-C6)alkyl, R3 is a —CO—(C11-C21)alkyl or —CO—(C11-C21)alkenyl group, or its pharmaceutically acceptable salts, racemates, diastereoisomers, enantiomers, or mixtures thereof, for use in prevention and/or treatment of a disease or disorder linked to an exacerbated vascular, lymphatic or mucosal permeability. |
| US11419838B2 |
Compositions comprising citrulline and leucine and their use in the treatment of diabetes and metabolic syndrome
Compositions contain citrulline and leucine or a metabolite thereof including, for example, a synergistic amount of citrulline and leucine. Such compositions may be used in methods for the treatment of pre-diabetes, metabolic syndrome, hyperglycemia, or diabetes. |
| US11419836B2 |
Racemic and near racemic beta-hydroxybutyrate mixed salt-acid compositions
Ketogenic compositions include a racemic or near racemic mixture of R- and S-beta-hydroxybutyric acids and a racemic or near racemic mixture of R- and S-beta-hydroxybutyrate salts. The R-enantiomer elevates ketone bodies and increases the rate at which ketosis is achieved. Including an equivalent or near equivalent amount of the S-enantiomer to provide alternative benefits. The R- and S-beta-hydroxybutyric acids are more rapidly absorbed and utilized by the body than salts or esters, enhance taste, and reduce the need to include other edible acids. The R- and S-beta-hydroxybutyrate salts are more slowly absorbed and utilized by the body and can provide one or more electrolytes. The composition may contain a dietetically or pharmaceutically acceptable carrier and a racemic or near racemic mixture of R- and S-beta-hydroxybutyrate salts and acids. The composition contains <100% by molar equivalents of total R,S-beta-hydroxybutyrate salts and >0% by molar equivalents of R,S-beta-hydroxybutyric acids. |
| US11419833B2 |
Nasally administered pharmaceutical composition for the treatment of epilepsy and related disorders
A nasally administered liquid, including suspension and viscous liquid compositions, containing a therapeutically effective quantity of (Z)-2-(3,5,5-trimethyl-2-cyclohexen-1-ylidene) acetic acid, its salts or analogs, combined with suitable pharmaceutical ingredients, to treat epilepsy. |
| US11419828B2 |
Hair care terpinen 4-ol (T4O) composition for the treatment of demodex mites on scalp
The present invention is a hair care compositions, and more particularly to hair care compositions that contain a novel blend of natural ingredients which can be applied to the scalp and/or hair of a user for the treatment of scalp demodex which inturn helps to prevent hair loss and stimulates hair growth on male scalp. The composition includes at least one essential oil, a carrier oil and additives. One of the essential oils included is tea tree oil, the active ingredient of which is Terpinen-4-ol solution (T40). |
| US11419827B2 |
Protecting tissue and mitigating injury from radiation-induced ionizing events
Materials and methods for reducing, preventing, or mitigating the effects of exposure to ionizing radiation are provided herein. In general, the methods can include administering a nanoparticulate genistein composition to a subject identified as having been exposed or at risk of being exposed to ionizing radiation, such as proton radiation. |
| US11419826B2 |
Surface-modified mesoporous silica nanoparticle for blood-brain barrier penetration,tumor targeting and cancer metastasis treatment, methods of production and uses thereof
The present disclosure relates to mesoporous silica nanoparticles (MSNs) with specific modifications as drug delivery systems containing both tumor targeting and blood-brain barrier (BBB) penetration properties suitable for cancer treatment and/or CNS disease treatment. The present disclosure also relates to method of preparing MSNs and the MSNs prepared by the method as described herein. |
| US11419825B2 |
Solid oral dosage form of irinotecan for the treatment of cancer
Provided is a composition, in particular a solid pharmaceutical composition comprising a compound having the formula I as a free base or a salt thereof, and a mixture comprising a vehicle and a non-ionic surfactant in an amount sufficient to achieve solubilization of compound (I), wherein typically the composition is coated with an enteric coating and its use in the treatment of cancer. |
| US11419824B2 |
Drug delivery system
The present invention relates to a drug delivery system, in particular for a controlled administration of one or more active pharmaceutical ingredients to a body, and further in particular for oral administration of one or more active pharmaceutical ingredients to a body. The system thereby comprises a base component soluble in body fluids and a separate first component soluble in body fluids. The first component thereby comprises a therapeutically effective amount of a first active pharmaceutical ingredient. |
| US11419818B2 |
System for managing inhalant and breath analysis devices
A computer-based system for receiving, analyzing, processing, managing and sending personal health information, and other information in conjunction with use of one or more personal nebulizer or vaporizing devices and personal breath analysis devices. System devices include a personal nebulizer or vaporizing unit with a mouthpiece, which may be detachable and replaceable. The mouthpiece includes an orifice through which vapor is emitted. The substance to be vaporized is contained in an ampoule inserted into the device, where the substance enters an atomization chamber where vaporization is achieved through piezoelectric transducers or atomizers providing sonic or ultrasonic vibration. The substance includes a variety of therapeutic, homeopathic, or naturopathic formulations, remedies, or serums. |
| US11419817B2 |
Drug delivery system for the delivery of antiviral agents
This invention relates to novel implant drug delivery systems for long-acting delivery of antiviral drugs. These compositions are useful for the treatment or prevention of human immunodeficiency virus (HIV) infection. |
| US11419815B2 |
Topical cosmetic compositions
Disclosed is a method of treating inflamed skin of a periorbital area of a person's face. The method can include topically applying to inflamed skin a composition comprising an oil extract of Opuntia ficus-indica tuna, Opuntia ficus-indica nopales, or a combination thereof, to reduce inflammation in skin cells of the periorbital area of the person's face. |
| US11419814B2 |
Transdermal compositions of ibuprofen and methods of use thereof
A transdermal composition comprising ibuprofen or salts thereof and a gelling agent which can be used for the treatment of such disorders as pain, inflammation, arthritis, muscle spasm and associated symptoms in humans and animals. |
| US11419811B2 |
Means and methods for preventing and/or treating caries
The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention. |
| US11419810B2 |
Topical skin care formulations comprising plant extracts
Disclosed is a method for treating skin. The method can include topically applying to skin a composition comprising an effective amount of an aqueous, alcoholic, aqueous-alcoholic, or oil-soluble extract from Condurango, wherein the Condurango extract reduces oxidation in the skin, reduces tumor necrosis factor alpha (TNF-α) activity in the skin, or reduces matrix metalloprotease (MMP) 3 activity in the skin. |
| US11419809B2 |
Hair treatment compositions and methods for treating hair
The instant disclosure relates to hair treatment compositions that include a unique combination of components that function to impart desirable cosmetic properties to the hair. The hair treatment compositions typically include a first phase containing a non-polymeric mono, di, or tricarboxylic acid, and/or a salt thereof, an amine, a cationic polymer, an alkoxysilane, polyols, and water; and a second phase containing a film-forming aminosilicone polymer formed by the reaction between a glycidoxypropyl-terminated dimethyl siloxane polymer, PEG-13 diglycidyl ether, diethylaminopropylamine, and aminopropyltriisopropoxysilane, and at least one silicone oil. |
| US11419808B2 |
Fibrous structures containing cationic surfactants and soluble acids
A fibrous structure with a plurality of fibrous elements. The fibrous elements contain a polymeric structurant; a fatty material with a melting point above 25° C.; a cationic surfactant, which can be selected from the group consisting of a mono-long alkyl amine, a tertiary amine, and combinations thereof; and an oil soluble acid. The oil soluble acid can be selected from the group consisting of salicylic acid, lactic acid, acetic acid, malic acid, succinic acid, sorbic acid, 2,4-dihydroxybenzoic acid, maleic acid, and combinations thereof. |
| US11419801B2 |
Personal care composition
The invention relates to a personal care composition, more particularly to a composition for application to a topical surface that prevents or reduces inflammation. The composition could be delivered in the form of a skin, scalp, hair or oral care product, more particularly a skin care product. The benefit is delivered via a combination of a polyunsaturated fatty acid (PUFA) or ester thereof selected from docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), DHA-ethyl ester, EPA-ethyl ester, DHA-triglyceride, EPA-triglyceride, dihomogamma-Linolenic Acid (DGLA), DGLA-ethyl ester, DGLA-triglyceride or combinations thereof and a 4-substituted resorcinol compound, wherein the mole ratio of the PUFA or ester thereof to the 4-substituted resorcinol compound is 5:1 to 1:5. |
| US11419798B2 |
Device for producing skin care pack using hydrogel, and control method thereof
A device for producing a skin care pack using a hydrogel and a control method thereof are disclosed. The device may include a housing which is provided with a door for selectively opening and closing a work space for forming a skin care pack, and which maintains a forming temperature required for producing the skin care pack; a platform including a base supported on a floor plate of the work space, and a heater for heating hydrogel discharged onto the base; a former including nozzle modules which are provided to be movable in the work space and each include a pump for receiving and discharging a heated hydrogel; and a control unit which controls the movement of the nozzle modules and the operation of the pumps, and maintains the temperature of the base to a predetermined range by controlling the operation of the heater. |
| US11419796B2 |
Stick-shaped cosmetic product
A stick-shaped cosmetic product including (a) 0.1 to 4 mass % of at least one selected from a partially cross-linked polyether modified silicone and a partially cross-linked polyglycerin modified silicone, (b) 1 to 10 mass % of wax, and (c) 30 mass % or more of an aqueous component. |
| US11419793B2 |
Pill sorting apparatus
A novel apparatus for allocating pills from a pharmacy pill container into a weekly pill storage container is described herein. The pill sorting apparatus is made of two parts, each with seven holes. The pills are poured into the sorting apparatus, and the two parts are shifted so that the holes align, allowing the seven pills to drop into the weekly pill storage container. |
| US11419791B2 |
Flexible container systems and nozzles, and related methods
A container system includes at least one flexible wall defining a compartment containing a dissolvable solid or concentrate, a support adjacent a first end of the at least one flexible wall, and a nozzle assembly coupled to a second end of the at least one flexible wall. The second end of the wall is distal from the first end. The nozzle assembly comprises a hollow body defining a longitudinal axis. The hollow body further defines a plurality of orifices through a wall thereof. Each orifice is able to form a fluid connection between an interior volume within the hollow body and the compartment. Each orifice is configured to deliver liquid from the interior volume to the compartment in a direction having an angle of between 5° and 85° from a direction of the longitudinal axis. Related nozzles and methods are also disclosed. |
| US11419789B1 |
Blister package lid
A blister package lid includes a substrate, a layer of adhesive, and a continuous pattern of electrically conductive wire disposed directly on the adhesive layer. The continuous pattern of wire has a plurality of detector segments, and the plurality of detector segments have respective destructible portions of wire at locations on the substrate corresponding to cavities of a blister sheet. Each detector segment has an outer connector portion and an inner connector portion. The outer connector portion and the inner connector portion of each detector segment are adjacent to one another, and pairs of successive first and second detector segments of the plurality of detector segments are connected by an arced segment between the inner connector portion of the first detector segment and the outer connector portion of the second detector segment. |
| US11419787B2 |
Dynamic sauna
Systems and methods are provided for controlling infrared radiation (IR) sources of a sauna including tuning IR wavelength-ranges and radiated power-levels of IR sources, and directing IR to locations on a user's body. In one illustrative embodiment, a sauna may be provided having adjustable IR emitters to emit IR at any wavelength resulting in a desirable radiation treatment for the sauna user. In another illustrative embodiment, a method is provided for tuning IR emitters in a sauna. |
| US11419782B1 |
Massage device
This massage device is configured to apply pressure to a human user's back, shoulders, or any distinct part of the musculoskeletal system. It can also be operated with a single arm and attaches to the user's forearm to apply pin-point or various pressure to target muscles. The massage device includes an arm plate that is configured to cover a forearm and a wrist of a human user. A hand grip is mechanically coupled to the arm plate and configured to accommodate the gripping of human fingers. A wrist bar is attached to the arm plate. A J-bar may be attached to the wrist bar. A tip is attached to the J-bar or directly to the short wrist bar. The tip is configured to provide variant pressure to the human user's back or shoulders or distal body part. Thereby duplicating mechanical pressure applied by a trained bodyworker by the untrained self at a much more reasonable price. |
| US11419781B2 |
Walking assitant robot
A walking assistant robot, comprising a main frame body (1), a foot walking mechanism for alternating walking, an auxiliary device (2) and a control device; the walking mechanism, the auxiliary device (2) and the control device are all disposed on the main frame body (1); the control device is connected with the walking mechanism; the auxiliary device (2) includes auxiliary feet (201), and the auxiliary feet (201) are disposed in front of and/or behind the walking mechanism along the walking direction. The foot walking mechanism is used to realize the basic function of the robot walking forward; auxiliary feet (201) are disposed in the walking direction such that the walking mechanism still has, at the moment of foot alternation, multiple supporting points in contact with the ground. Therefore, the mechanism is slip-and-fall-resistant, stable and reliable and guarantees the user safety. |
| US11419776B2 |
Patient support usable with bariatric patients
A patient support includes a height adjustable patient support deck, at least one guard structure mounted relative to the patient support deck along a side of the patient support, with the guard structure movable both vertically and laterally along the side of the patient support, and the guard structure positionable beneath at least the patient support deck. The patient support further includes a control system configured to determine whether the guard structure is located beneath the patient support deck and to enable or disable a function of the patient support and/or to adjust a parameter of the patient support when the guard structure is located beneath the patient support deck. |
| US11419774B2 |
Mobility vehicle
A mobility vehicle may comprise a frame, a first pivot arm, a second pivot arm, and a suspension assembly. The first pivot arm may be coupled to the frame and coupled to a drive wheel. The second pivot arm may be coupled to the frame and coupled to a ground engaging caster wheel. The suspension assembly may be coupled to the frame. The suspension assembly may include a first spring assembly and a second spring assembly. The first spring assembly may be disposed about a first spring axis and coupled to the first pivot arm. The second spring assembly may be disposed about a second spring axis and coupled to the second pivot arm. The first spring axis and the second spring axis may be disposed relative to each other at an angle of no greater than about 150° when the mobility vehicle is operating on horizontal ground. |
| US11419772B2 |
Wheelchair system with motion sensors and neural stimulation
A system and method for improving stability of a wheelchair user includes a wheelchair having sensors measuring motion parameters to sense collisions and sharp turns which may unseat the user. Neuromuscular stimulating electrodes attached to extensor and flexor muscles of the user's trunk and under the command of a controller in communication with the sensors activate the muscles during turns and collisions to counteract the forces induced. A system and method for increasing manual propulsion efficiency includes sensors for sensing motion parameters indicating completion of a manual push of the wheelchair wheels and recovery from the push. Neuromuscular stimulating electrodes attached to extensor and flexor muscles of the user's trunk and under the command of a controller in communication with the sensors activate the muscles at the appropriate time in the cycle of push and recovery. |
| US11419770B2 |
Bandage with UV disinfectant and microneedles for antimicrobial delivery and fluid absorption from a wound
A bandage is formed of a film layer, an adhesive applied to the film layer, and an absorbent layer connected to the film layer. The absorbent layer comprises a compressed fabric soaked in a fluid. A permeable membrane is disposed over the absorbent layer and creates an electrical charge when fluid from the absorbent layer passes through the membrane. The electricity generated by the osmosis flows to a plurality of light emitting diodes that are connected to the membrane through a battery. The LEDs emit UV light to disinfect a wound when a bandage is applied to the wound. |
| US11419769B2 |
Sublingual films
The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson's disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith. |
| US11419768B2 |
Reduced pressure, compression systems and apparatuses for use on joints
A system for providing reduced-pressure treatment to a moveable tissue site, such as a joint, includes a flexible dressing bolster. The flexible dressing bolster has a first side and a second, inward-facing side, and a plurality of flexion joints formed on the flexible dressing bolster. The system further includes a sealing subsystem for providing a fluid seal over the flexible dressing bolster and the patient's epidermis and a reduced-pressure subsystem for delivering a reduced pressure to the sealing subsystem. The sealing subsystem and reduced-pressure subsystem are operable to deliver a reduced pressure to the moveable tissue site. The flexible dressing bolster is operable to allow articulation or movement of the moveable tissue site. The sealing subsystem may include a drape with folds. Other systems, apparatuses, and methods are presented. |
| US11419765B2 |
Ophthalmological patient interface apparatus
An ophthalmological patient interface apparatus, having a coupling apparatus for mechanically coupling to an application head of an ophthalmological laser system, comprises a lens-element system which is arranged between the eye and the application head in the state coupled to the application head during the treatment of an eye, said lens-element system being coupled into the beam path from the projection lens to the eye. The lens-element system is configured to image a first focal area of the projection lens disposed upstream of the lens-element system in the beam path onto a second focal area in the eye disposed downstream of the lens-element system in the beam path, in such a way that a laser beam focused onto the first focal area by the projection lens causes tissue processing in the second focal area in the eye. |
| US11419761B2 |
Glaucoma aqueous humor drainage device and glaucoma aqueous humor drainage method
A glaucoma aqueous humor drainage device and a glaucoma aqueous humor drainage method, wherein the opening and closing of a pressure valve is controlled by the change in the pressure in a cavity of the valve. When the pressure in the intraocular pressure exceeds 12 mmHg, the valve is opened, and a drainage tube connected behind the valve drains the aqueous humor to the ocular surface, reducing the patient's discomfort and dry eyes, effectively draining the aqueous humor and avoiding scarring caused by embedding the device via a conjunctival flap and operation failure caused by increase of intraocular pressure caused by generation of filtering blebs. |
| US11419757B2 |
Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
Methods, devices, and systems employ cryolysis of oropharyngeal adipose tissues to selectively remove fat cells from the tissues causing obstructive sleep apnea. In various embodiments, a chilled liquid—e.g., a liquid or air—is applied to the target tissue at a temperature and for a duration sufficient to cause cryolysis. |
| US11419756B2 |
Athlete's recovery system
In one instance, a recovery system for a user is presented that includes a battery-operated, flexible wrap that applies heat with both conductive heat and radiant heat. The recovery system has a control unit that ramps the temperature applied using primarily perceived conductive heat before leveling at a target temperature. Other systems and devices are presented. |
| US11419747B2 |
Terrain adaptive powered joint orthosis
A powered device augments a joint function of a human during a gait cycle using a powered actuator that supplies an augmentation torque, an impedance, or both to a joint. A controller estimates terrain slope and modulates the augmentation torque and the impedance according to a phase of the gait cycle and the estimated terrain slope to provide at least a biomimetic response. The controller may also modulate a joint equilibrium. Accordingly, the device is capable of normalizing or augmenting human biomechanical function, responsive to a wearer's activity, regardless of speed and terrain, and can be used, for example, as a knee orthosis, prosthesis, or exoskeleton. |
| US11419737B2 |
Orthopedic leg alignment system and method
An orthopedic measurement system is disclosed to measure leg alignment. The measurement system includes a tri-axial gyroscope configured to measure movement of a leg. The gyroscope is coupled to a tibia of the leg. For example, the gyroscope can be placed in an insert or tibial prosthetic component that couples to the tibia. The gyroscope is used to measure alignment relative to the mechanical axis of the leg. The leg alignment measurement is performed by putting the leg through a first leg movement and a second leg movement. The gyroscope outputs angular velocities on the axes the sensor is rotated about. The gyroscope is coupled to a computer that calculates the alignment of the leg relative to the mechanical axis from the gyroscope measurement data. |
| US11419735B2 |
Expandable TLIF device and related insertion and grafting instrumentation
An expandable interbody fusion device and an associated instrument for inserting the device into an intervertebral disc space, expanding the device and for use in delivering graft material into the device once expanded in the disc space. The device is small enough to fit through Kambin's triangle yet is capable of expanding both in the vertical direction to accommodate spinal lordosis and in the lateral direction to provide sufficient structural support for opposing vertebral bodies laterally within the disc space. A process of forming textured top and bottom surfaces of the device by initially laser ablating each surface with a nano-second pulsed laser followed by laser ablating those surfaces with a femto-second pulsed laser. |
| US11419734B2 |
Intervertebral implant
An intervertebral implant includes opposing upper and lower endplates that are configured to engage respective vertebral surfaces in an intervertebral space. The implant carries a plurality of bone fixation spikes that extend out from each endplate. The spikes define a plurality of outer surfaces that extend from a base to a tip. The spikes are laterally staggered, and have a height that increases along a longitudinal direction from the front toward the rear of the implant, and a define recess formed in at least one outer surfaces. |
| US11419728B2 |
Implant for reconstructing an acetabulum and at least part of a pelvic structure
The present invention provides an implant for reconstructing an acetabulum and at least part of a pelvic structure. To this end, the implant comprises a frame structure embodied by at least one first profile element for transferring joint forces, a joint section which forms at least part of an artificial acetabulum, at least two attachment sections for attaching the implant to bone tissue, wherein a first attachment section is provided for attachment to a sacral bone or iliac bone and a second attachment section is provided for attachment to a pubic bone, and at least one plate element for supporting internal organs, which is surrounded by the frame structure, at least in sections. |
| US11419711B2 |
Implantable superhydrophobic surfaces
Bio-adhesive textured surfaces are described which allow implants to be localized within a living body. Hierarchical levels of texture on an implantable medical device, some capable of establishing a Wenzel state and others a Cassie state, may be employed to interface with living structures to provide resistance to device migration. Since a gaseous state is traditionally required to establish a Cassie or Wenzel state, and gases do not remain long in living tissue, described herein are tissue/device interactions analogous to the above states with the component normally represented by a gas replaced by a bodily constituent, wherein separation of tissue constituents develops and an analogous Cassie, Wenzel, or Cassie-Wenzel state evolves. Further methods of making molds to produce said devices are described herein. |