最新美国发明专利第2021-03-16期 - 专利汇|PatentHub专利检索|专利查询网|发明专利查询分析

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US10947348B2	Fluorochemical piperazine carboxamides The disclosure provides partially fluorinated piperazine carboxamide compounds having terminal fluoroaliphatic groups and polysiloxane groups. This invention also relates to polymer compositions comprising the fluorochemical composition and shaped articles made from the thermoplastic composition. See Formula (I).
US10947337B2	Toughened epoxy resin composition A toughened epoxy resin composition includes an end-capped polyalkylene oxide (A), an epoxy resin (B), an epoxy curing agent (C), and a core shell polymer (D). The end-capped polyalkylene oxide (A) has a number average molecular weight of 1500 to 5000, and 40% or more of a total number of ends of the end-capped polyalkylene oxide (A) are capped with at least one selected from the group consisting of an alkyl group, an allyl group, and an aryl group. A weight ratio of the end-capped polyalkylene oxide (A) to the core shell polymer (D) is 10/90 to 90/10. The core shell polymer (D) comprises a core layer in an amount of 70 to 95% by weight and the core layer is one or more selected from the group consisting of diene rubber, (meth)acrylate rubber, organosiloxane rubber, styrene polymer, and (meth)acrylate polymer.
US10947327B2	Catalyst composition including novel transition metal compound The present invention relates to a catalyst composition including a transition metal compound represented by the following Formula 1; and one or more of a compound represented by the following Formula 2, a compound represented by the following Formula 3 and a compound represented by the following Formula 4. The catalyst composition according to the present invention has excellent copolymerization properties, and can be usefully used as a catalyst for a polymerization reaction for preparing an olefin-based polymer having a high molecular weight.
US10947325B2	Regulators for controlling linear and pseudo-ring expansion polymerization of vinyl monomers New regulator compounds for a novel polymerization process for vinyl monomers, which yields polymers with improved control over composition and nearly full to full conservation of architectural integrity up to high conversion. The regulator compounds are defined by according to anyone of the Formulas 1A, 1B, 1C, 1D, 1E, 1F, 1G, 1H and 1I: wherein R1 stands for an optionally substituted secondary or tertiary alkyl or secondary or tertiary aralkyl; Z1 stands for —CN or a carboxylic acid ester of formula C(O)OR21; Z2 may be chosen from the group of —CN, carboxylic acid, salts of carboxylic acids, carboxylic acid ester, carboxylic acid amides, (hetero)aryl, alkenyl and halogen; R2, R3, R4 and R5 are each independently chosen from the group of H, alkyl, aralkyl, (hetero)aryl, —CN and carboxylic acid ester of formula C(O)OR22; R7 stands for a primary alkyl or primary aralkyl, —CN or hydrogen; Y stands for a bridging group and n is 2, 3, 4, 5 or 6; in case R1 stands for tertiary alkyl or tertiary aralkyl, R6 stands for a primary alkyl or primary aralkyl, —CN or a carboxylic acid ester of formula C(O)OR26; in case R1 stands for a secondary alkyl or secondary aralkyl, R6 stands for a primary or secondary alkyl or primary or secondary aralkyl, —CN, a carboxylic acid ester of formula C(O)OR26 or a phosphonic acid ester of formula P(O)(OR27)2, a (hetero)aryl or an alkenyl; R21, R22, R26 and R27 each independently stand for alkyl or aralkyl having from 1-30 carbon atoms, optionally containing heteroatoms.
US10947322B2	Esterified cellulose ethers comprising phthalyl groups An esterified cellulose ether is provided wherein the ester groups are phthalyl groups, the degree of substitution of phthalyl groups is from 0.02 to 0.18, the degree of neutralization of phthalyl groups is not more than 0.75, and the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 2° C.
US10947321B2	Host-guest metal organic framework systems A method for producing Metal Organic Framework (MOF) having a framework that encapsulates a bio-molecule, the method comprising combining in a solution the bio-molecule and MOF precursors, wherein the bio-molecule promotes formation of the encapsulating framework. The method stems from a surprising effect that a bio-molecule can promote or trigger the formation of MOF when combined together in a solution with MOF precursors. That is, it has now been found that a bio-molecule can effectively act as a seed around which the framework forms, with the resulting framework encapsulating the bio-molecule.
US10947319B2	Bispecific antigen-binding constructs targeting HER2 Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.
US10947318B2	IgE anti-HMW-MAA antibody In one aspect, there is provided an antibody or a functional fragment thereof, wherein the antibody or functional fragment thereof is capable of binding specifically to high molecular weight melanoma associated antigen (HMW-MAA), and binding to an Fcε receptor.
US10947317B2	NaPi2b-targeted antibody-drug conjugates and methods of use thereof This disclosure provides NaPi2b-targeted antibody-drug conjugates (e.g., NaPi2b-targeted antibody-polymer-drug conjugates) that specifically bind to the extracellular region of SLC34A2, and to methods of using such conjugates in a variety of therapeutic, diagnostic, and prophylactic indications.
US10947315B2	Benzodiazepine derivatives The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
US10947310B2	Fusion protein comprising apelin and an anti-APLNR antibody The present invention provides apelin receptor (APLNR) modulators that bind to APLNR and methods of using the same. The invention includes APLNR modulators such as antibodies, or antigen-binding fragments thereof, which inhibit or attenuate APLNR-mediated signaling. The invention includes APLNR modulators such as antibodies, or antibody fusion proteins thereof, that activate APLNR-mediated signaling. According to certain embodiments of the invention, the antibodies or antigen-binding fragments or antibody fusion proteins are fully human antibodies that bind to human APLNR with high affinity. The APLNR modulators of the invention are useful for the treatment of diseases and disorders associated with APLNR signaling and/or APLNR cellular expression, such as cardiovascular diseases, angiogenesis diseases, metabolic diseases and fibrotic diseases.
US10947308B2	Composition for treatment of disorders The invention relates to stable and non-aggregating compositions comprising an IL-17A binding molecule, in particular a single domain antibody. Such compositions are useful for topical administration in the treatment of disease, for example skin disease or asthma.
US10947307B2	Antibody formulations Formulations comprising an anti-IL-13 antibody are provided, including pharmaceutical formulations and methods of using such formulations.
US10947306B2	Correctly folded etanercept in high purity and excellent yield A mixed mode chromatography method for separating correctly folded from incorrectly folded conformations of a given protein is provided. The method is highly effective in separating correctly folded etanercept from incorrectly folded etanercept and aggregates in commercially attractive yields capable of affording etanercept preparations having very high purity in terms of correctly folded etanercept versus incorrectly folded etanercept. The invention is further directed to protein preparations and formulations comprising correctly folded proteins obtained using the present methods, and methods of treatment using the high purity preparations obtained from the mixed mode method.
US10947304B2	Gremlin-1 antibody This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.
US10947303B2	TGF-ß1 specific antibodies and methods and uses thereof Specific binding members, particularly antibodies and fragments thereof, which bind to transforming growth factor beta 1 (TGF-β1) are provided, particularly recognizing human and mouse TGF-β1 and not recognizing or binding TGF-β2 or TGF-β3. Particular antibodies are provided which specifically recognize and neutralize TGF-β1. These antibodies are useful in the diagnosis and treatment of conditions associated with activated or elevated TGF-β1, including cancer, and for modulating immune cells and immune response, including immune response to cancer or cancer antigens. The anti-TGF-β1 antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies hereof, including antibody 13A1, whose sequences are provided herein.
US10947296B2	Fusion protein Slit2D2(C386S)-HSA and use thereof in treatment of fibrotic diseases The present invention relates to the field of biomedical technology, in particular to a fusion protein Slit2D2(C386S)-HSA and use thereof in the treatment and/or prevention of fibrotic diseases. In the fusion protein, the amino acid residue is mutated on the basis of the Slit2D2 domain, which improves the stability of the fusion protein compared with the native protein. The above fusion protein is obtained by fusing Slit2D2(C386S) with HSA protein, which prolongs the metabolism time of the drug while improving the stability of the drug. The fusion protein provided by the present invention is more effective than the positive control drug in the prevention and treatment of fibrotic diseases, particularly pulmonary fibrosis, and shows good drug-forming properties.
US10947294B2	Peptides and combination of peptides for use in immunotherapy against various tumors A method of treating a patient who has hepatocellular carcinoma (HCC), colorectal carcinoma (CRC), glioblastoma (GB), gastric cancer (GC), esophageal cancer, NSCLC, pancreatic cancer (PC), renal cell carcinoma (RCC), benign prostate hyperplasia (BPH), prostate cancer (PCA), ovarian cancer (OC), melanoma, breast cancer (BRCA), CLL, Merkel cell carcinoma (MCC), SCLC, Non-Hodgkin lymphoma (NHL), AML, gallbladder cancer and cholangiocarcinoma (GBC, CCC), urinary bladder cancer (UBC), and uterine cancer (UEC) includes administering to said patient a composition containing a population of activated T cells that selectively recognize cells in the patient that aberrantly express a peptide. A pharmaceutical composition contains activated T cells that selectively recognize cells in a patient that aberrantly express a peptide, and a pharmaceutically acceptable carrier, in which the T cells bind to the peptide in a complex with an MHC class I molecule, and the composition is for treating the patient who has HCC, CRC, GB, GC, esophageal cancer, NSCLC, PC, RCC, BPH, PCA, OC, melanoma, BRCA, CLL, MCC, SCLC, NHL, AML, GBC, CCC, UBC, and/or UEC. A method of treating a patient who has HCC, CRC, GB, GC, esophageal cancer, NSCLC, PC, RCC, BPH, PCA, OC, melanoma, BRCA, CLL, MCC, SCLC, NHL, AML, GBC, CCC, UBC, and/or UEC includes administering to said patient a composition comprising a peptide in the form of a pharmaceutically acceptable salt, thereby inducing a T-cell response to the HCC, CRC, GB, GC, esophageal cancer, NSCLC, PC, RCC, BPH, PCA, OC, melanoma, BRCA, CLL, MCC, SCLC, NHL, AML, GBC, CCC, UBC, and/or UEC.
US10947293B2	Peptides and combination of peptides for use in immunotherapy against various tumors The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
US10947288B2	Targeting of human interferon antagonists The present invention relates to a fusion protein, comprising a cytokine antagonist and a targeting moiety, preferably an antibody or anti-body like molecule. In a preferred embodiment, the cytokine antagonist is a modified cytokine which binds to the receptor, but doesn't induce the receptor signalling. The invention relates further to a fusion protein according to the invention for use in treatment of cancer and immune- or inflammation-related disorders.
US10947285B2	Compounds, compositions and uses thereof for improvement of bone disorders The present technology generally relates to peptides of IGFBP-2 that may be used to improve bone disorders. The present technology also generally relates to uses of such peptides in methods for preventing or treating bone disorders and to compositions for such uses.
US10947282B2	Functionalized protein-based materials and their uses Embodiments of the invention are directed to Ubx-fusion molecules that maintain their mechanical strength and properties even after being fused with Ubx. Ubx fusions with VEGF and other growth factors, cell signaling proteins, and cell binding proteins can be used to induce angiogenesis. Ubx fibers and mesh, embedded within a tissue engineering scaffold, induce formation of vasculature within the scaffold. The presence of vasculature is necessary to provide oxygen and nutrients to other cells growing within the scaffold.
US10947279B2	Synthetic peptide compounds and methods of use The present invention provides synthetic peptide compounds and uses thereof for therapy and diagnostics of complement-mediated diseases, such as inflammatory diseases, autoimmune diseases, and microbial and bacterial infections; and non-complement-mediated diseases, such cystic fibrosis and various acute diseases. The invention is directed to modifications of a synthetic peptide of 15 amino acids from the Polar Assortant (PA) peptide, which is a scrambled peptide derived from human Astrovirus protein. In some embodiments, the invention is directed to peptide compounds that are peptide mimetics, peptide analogs and/or synthetic derivatives of PA (e.g., sarcosine derivatives) having, for example, internal peptide substitutions, and modifications, including PEGylation at the N-terminus and C-terminus. The invention further provides methods of selecting at least one synthetic peptide for treating various conditions.
US10947276B2	Cell penetrating peptides with improved internalization properties A method for delivering a cargo molecule into a cell is described that comprises linking a cargo molecule to a cell penetrating peptide. Chimeric constructs comprising cell penetrating moieties are also provided.
US10947275B2	Caged cell penetrating peptide-polymer conjugates for diagnostic and therapeutic applications The caged cell-penetrating peptide (cCPP) conjugates of this invention are ideal for intracellular delivery of a broad variety of cargoes including various nanoparticle pharmaceutical carriers (liposomes, micelles, microparticles, nanoparticles, polymer-conjugates). The conjugates comprise a detectable agent or a therapeutic agent, and the conjugates provide a novel strategy for site-specific delivery of the same to appropriate tissues in the subject. Versatile application of the conjugates in diagnostics and imaging is described.
US10947269B2	Purification of chimeric FVIII molecules The invention is directed to methods of purifying a chimeric protein comprising subjecting the chimeric protein to a factor VIII-specific affinity chromatography, and subjecting the chimeric protein to an AEX chromatography; wherein the chimeric protein comprises a factor VIII protein or a fragment thereof. The chimeric protein purified by the present methods shows improved factor VIII activity.
US10947268B2	Methods of purifying proteins In some embodiments, the present invention provides a method of purifying a protein of interest with a reduced level of aggregation formation in cation exchange (CEX) chromatography, comprising: (a) providing a mixture comprising the protein of interest and one or more contaminants; (b) loading the mixture onto a CEX resin coupled with arginine; and (c) eluting the protein of interest from the resin, thereby purifying the protein of interest with a reduced level of aggregation formation in CEX chromatography.
US10947267B2	System and method for solution phase gap peptide synthesis Disclosed is a system and method for Fmoc/tBu solution-phase peptide synthesis including the development of a new benzyl-type GAP protecting group, and related uses thereto. This novel GAP protecting group is utilized in place of a polymer support, facilitating C to N Fmoc peptide synthesis without chromatography, recrystallization, or polymer supports. The GAP group can be added and removed in high yield.
US10947265B2	Synthesis of ursolic acid nanoparticles The synthesis of ursolic acid nanoparticles includes dissolving ursolic acid powder in methanol, boiling water for five minutes, and adding the methanol solution to the boiled water dropwise at a flow rate of 0.1-0.3 ml/min under ultrasonic conditions. After sonication for 20 minutes, the contents are stirred for about 15 minutes, and then dried. Particle size distribution studies and TEM micrographs confirm the resulting product comprises nanoparticles. In vitro testing confirms the ursolic acid nanoparticles exhibit greater anticancer activity than conventional-size particles, and that the nanoparticles exhibit antimicrobial effect against gram positive and gram negative bacteria, as well as fungi.
US10947263B2	Cyclic dinucleotides as anticancer agents The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
US10947262B2	Hydrophobic interaction chromatography for purification of oligonucleotides The invention herein describes a method to purify a target oligonucleotide using hydrophobic interaction chromatography (HIC). The method includes adding a salt to a mixture of the target oligonucleotide and product-related impurities, applying the diluted mixture, at a particular dynamic loading capacity, to the hydrophobic interaction chromatography resin (or hydrophobic adsorbent), washing the hydrophobic adsorbent with an aqueous salt solution, eluting the target oligonucleotide with a eluting solution, and collecting the eluent comprising the target oligonucleotide.
US10947257B2	Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
US10947250B2	3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative and method for synthesizing optical isomer thereof The present invention relates to a method for synthesizing a 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative and an optical isomer thereof, and an intermediate Compound which may be used for the synthesis method, and when the method and the intermediate Compound are used, the 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative and the optical isomer thereof may be effectively synthesized.
US10947246B2	Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof The present invention provides substituted pyrrolo-, furano-, and cyclopentylpyrimidine bicyclic compounds of Formula III, and Formula IV, and pharmaceutically acceptable salts, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds and pharmaceutical compositions for treating tumor cells and inhibiting mitosis of cancerous cells.
US10947245B2	Crystal form A of 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine for inhibiting toll-like receptor activity The present invention relates to crystalline form A of a TLR7 agonist 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)-benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine (formula I), a method for preparing the crystalline form A, and the use thereof.
US10947244B2	Forms of a PI3K delta selective inhibitor for use in pharmaceutical formulations The present invention relates to solid state forms of a p-toluenesulfonic acid salt (PTSA) of the selective PI3K delta inhibitor (S)-2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one (TGR-1202). The present invention also relates to methods of preparing the same, pharmaceutical compositions containing them, and methods of treating a PI3K kinase mediated disease or disorder, such as cancer, by administering the same.
US10947239B2	[1,2,4]triazolo[1,5-a]pyrimidin-7-yl compound The present invention relates to a novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivative as inhibitor of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compound, to processes for preparing such compound and compositions, and to the use of such compound and compositions for the prevention and treatment of disorders in which PDE2 is involved, such as neurological and psychiatric disorders.
US10947236B2	Pyrrolo-dipyridine compounds In one aspect, the invention provides compounds of Formula I Formula Ia, Formula Ib, Formula Ic, and Formula Id and salts, hydrates and isomers thereof. In another aspect, the invention provides a method of promoting bone formation in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of Formula I, Formula Ia, Formula Ib, Formula Ic, or Formula Id. The present invention also provides orthopedic and periodontal devices, as well as methods for the treatment of renal disease, diabetes bone loss, and cancer, using a compound of Formula I, Formula Ia, Formula Ib, Formula Ic, or Formula Id.
US10947233B2	Crystals of azabicyclic compound Provided are crystals of 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide which are stable and show excellent oral absorbability.The crystals are Form II crystals of 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide showing an X-ray powder diffraction spectrum having at least three characteristic diffraction peaks at angles (2θ±0.2°) selected from the group consisting of 7.7°, 8.0°, 11.1°, 12.5°, 12.9°, 15.2°, 15.8°, 17.2°, 19.0°, 22.5°, 26.1°, and 27.4°.
US10947230B2	Bicyclic heterocycles as FGFR inhibitors The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
US10947229B2	Dimethyl amino azetidine amides as JAK inhibitors The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.
US10947225B2	Phosphotidylinositol 3-kinase inhibitors This disclosure relates to phosphoinositide 3-kinases (PI3Ks) inhibitors such as N-(5-(imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)sulfonamide derivatives and uses related thereto. In certain embodiments, the disclosure relates to methods of treating PI3K associated diseases or conditions comprising administering an effective amount of a compound disclosed herein to a subject in need thereof. In certain embodiments, the subject is at risk of, exhibiting symptoms of, suffering from, or diagnosed with cancer or a hematological malignancy.
US10947222B2	Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 The present invention relates to a compound represented by formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, nonalcoholic steatohepatitis (NASH), cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
US10947221B2	Bryostatin compounds and methods of preparing the same Methods for preparing a variety of bryostatin compounds are provided. The subject methods provide for preparation of bryostatin 1 in multi-gram quantities in a low and unprecedented number of convergent synthetic steps from commercially available materials. The subject methods are scalable with low estimated material costs and can provide enough material to meet clinical needs. Also provided are a variety of bryostatin analog compounds, and prodrug forms thereof, which are synthetically accessible via the subject methods and pharmaceutical compositions including the same.
US10947220B2	Anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases Disclosed are compounds that modulate the physiological action of the proprotein convertase subtilisin kexin type 9 (PCSK9), as well as therapeutic methods for use of such compounds to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease (CVD), including treatment of hypercholesterolemia.
US10947219B2	Enantioselective process for the manufacture of lactam carboxylate derivatives The present invention relates an enantioselective process for the manufacture of a compound of formula (D) wherein ring A, RB2 and RB3 are as defined in claim 1.
US10947209B2	Method for preparing 2, 5-furandimethylcarboxylate from hydroxymethylfurfural An embodiment of the present invention provides a method of preparing 2,5-furandimethylcarboxylate (FDMC), including preparing 2,5-furandimethylcarboxylate (FDMC) by subjecting a reaction mixture including 5-hydroxymethylfurfural (HMF), air, and an alcohol solvent to oxidative esterification in the presence of a gold (Au)-nanoparticle-supported catalyst, in which the gold (Au)-nanoparticle-supported catalyst includes a support and gold (Au) nanoparticles supported on the support.
US10947207B2	GP130 modulators There are provided, inter alia, compounds and methods useful for the treatment of neurological conditions, such as neurological disorders and neurodegenerative diseases, including Alzheimer's Disease.
US10947206B2	cGAS antagonist compounds Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
US10947205B2	Oxazolidinone compounds and methods of use thereof as antibacterial agents The present invention relates to oxazolidinone compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. The present invention also relates to compositions which comprise at least one oxazolidinone compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of an oxazolidinone of the invention and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.
US10947204B1	Method for preparing sodium nitrotetrazolate using cation exchange resin The present invention is directed to a method for preparing 5-nitrotetrazolate using a strongly acidic ionic cation exchange resin that has improve yields over prior art methods. The methods disclosed herein can be used either in a batch process or continuous flow reactor. In one exemplary process, starting material sodium 5-aminotetrazolate in solution is added into a reaction vessel containing a strongly acidic ionic cation exchange resin to facilitate production of 5-nitrotetrazolate. Multiple reactors containing resins may be connected in series to improve 5-nitrotetrazolate yields and purity levels.
US10947199B2	Spiro and cyclic bis-benzylidene proteasome inhibitor for the treatment of cancer, diabetes and neurological disorders Described herein are spiro and cyclic bis-benzylidine proteasome inhibitors, which inhibit the proteasome function through either ubiquitin receptor ADRM1/RPN13 or proteasome DUB enzymes (USP14, UCH37 and RPN11), and which can be used for the treatment of cancers/diabetes/neurological disorders.
US10947186B2	Process for hydrocyanation of terminal alkynes The present invention refers to a process for a Rh-catalyzed Anti-Markovnikov hydrocyanation of terminal alkynes which process discloses, for the first time, the highly stereo- and regio-selective hydrocyanation of terminal alkynes to furnish E-configured alkenyl nitriles and the catalyst used in the present process.
US10947183B2	Fenfluramine compositions and methods of preparing the same Methods of preparing a fenfluramine active pharmaceutical ingredient are provided. Aspects of the method include (a) hydrolyzing a 2-(3-(trifluoromethyl)phenyl)acetonitrile composition to produce a 2-(3-(trifluoromethyl)phenyl)acetic acid composition; (b) reacting the 2-(3-(trifluoromethyl)phenyl)acetic acid composition with acetic anhydride and a catalyst to produce a 1-(3-(trifluoromethyl)phenyl)propan-2-one composition; and(c) reductively aminating the 1-(3-(trifluoromethyl)phenyl)propan-2-one composition with ethylamine using a borohydride reducing agent to produce a fenfluramine composition. Also provided are compositions and pharmaceutical ingredients prepared according to the subject methods including a pharmaceutically acceptable salt of fenfluramine and having less than 0.2% by weight in total of trifluoromethyl regioisomers.
US10947182B1	Cinnamyl alcohol cassic acid ester with antibacterial activity and a method of preparing the same A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.
US10947173B2	Method for purifying 1,1,1,2,2-pentafluoropropane The present invention relates to a process for purifying a stream including 1,1,1,2,2-pentafluoropropane, comprising the steps of i) providing a stream A comprising 1,1,1,2,2-pentafluoropropane and at least one of the compounds selected from the group consisting of 2-chloro-1,1,1,3,3-pentafluoropropane, 1,2-dichloro-3,3,3-trifluoropropene, 2-chloro-1,3,3,3-tetrafluoropropene; ii) purification, preferably by distillation, of the stream A provided in i) in order to form a first stream A1 comprising 1,1,1,2,2-pentafluoropropane, preferably recovered at the top of the distillation column, and a second stream A2 comprising said at least one of the compounds selected from the group consisting of 2-chloro-1,1,1,3,3-pentafluoropropane, 1,2-dichloro-3,3,3-trifluoropropene, 2-chloro-1,3,3,3-tetrafluoropropene, preferably recovered at the bottom of the distillation column.
US10947167B2	Biochar The invention provides for methods, devices, and systems for pyrolyzing biomass. A pyrolysis unit can be used for the pyrolysis of biomass to form gas, liquid, and solid products. The biomass materials can be selected such that an enhanced biochar is formed after pyrolysis. The biomass can be pyrolyzed under specified conditions such that a selected biochar core is formed. The pyrolysis process can form a stable biochar core that is inert and/or resistant to degradation. The biochar or biochar core can be functionalized to form a functionalized biochar or functionalized biochar core. Functionalization can include post-pyrolysis treatments such as supplementation with microbes or physical transformations including annealing and/or activation.
US10947150B2	Decoy security based on stress-engineered substrates A system includes a stress-engineered substrate comprising at least one tensile stress layer having a residual tensile stress and at least one compressive stress layer having a residual compressive stress. The at least one tensile layer and the at least one compressive layer are coupled such that the at least one tensile stress layer and the at least one compressive stress layer are self-equilibrating. At least one functional device is disposed on the stress-engineered substrate. The stress-engineered substrate is configured to fracture in response to energy applied to the substrate. Fracturing the stress-engineered substrate also fractures the functional device. The system includes at least one decoy device. Fragments of the decoy device are configured to obscure one or more physical characteristics of the functional device and/or one or more functional characteristics of the functional device after the functional device is fractured.
US10947148B2	Laser beam cutting/shaping a glass substrate An apparatus includes a beam splitter and a plurality of mirrors. The beam splitter is positioned to receive a laser beam from a source and split the received laser beam to a first plurality of split laser beams and a second plurality of split laser beams. The plurality of mirrors is configured to direct the first plurality of split laser beams and further configured to direct the second plurality of split laser beams. The first plurality of split laser beams is directed by the plurality of mirrors is configured to cut a glass substrate. The second plurality of split laser beams is directed by the plurality of mirrors is configured to shape the glass substrate.
US10947141B2	Systems and methods for controlling denitrification in a denitrifying biological reactor Methods and systems for controlling a denitrification reaction in a biological nitrogen removal reactor including denitrifying bacteria to favor denitratation of nitrate to nitrite and limit denitritation of nitrite to nitrogen gas are disclosed. pH, dissolved oxygen levels, solids retention time, and chemical oxygen demand to nitrogen ratio are controlled to favor this reaction. Wastewater or contaminated groundwater including concentrations of ammonium and nitrate are continuously fed to the biological nitrogen removal reactor along with a source of carbon and electrons as an influent, which is treated to form a nitrite effluent. The nitrite effluent may then be fed to an anammox reactor including anammox bacteria for production of nitrogen gas. The system may be operated under substantially anoxic conditions, which provides significant cost savings without sacrificing efficiency or productivity compared to traditional wastewater treatment systems and processes.
US10947137B2	Process for treatment of mine impacted water A process for treating mine impacted water containing one or more reduced selenium species by an advanced oxidation process (AOP) including ozone and ultraviolet light, or ozone and hydrogen peroxide is disclosed. The process oxidizes the one or more reduced selenium species to selenate and thereby produces AOP treated water. Residual oxidants are removed from the AOP treated water.
US10947132B2	System and methods for removing dissolved metals from wastewater streams A photocatalytic reaction unit for removing dissolved metals from a wastewater stream, including a photocatalytic reaction vessel having an inlet and an outlet for providing passage of the wastewater stream into and out of the photocatalytic reaction vessel; a photocatalyst for mixing with the wastewater stream; and an ultraviolet light source for emitting ultraviolet light into the photocatalytic reaction vessel.
US10947129B2	Fluid disinfection with ultraviolet radiation and a chemical disinfectant There is described an on-line device for controlling a fluid treatment process configured to inactivate a microorganism in a flow of fluid using ultraviolet radiation and a chemical disinfectant. The device includes: a memory for receiving a calculated database of dose response for the ultraviolet radiation and for the chemical disinfectant for a fluid treatment parameter; means to obtain input data about the fluid treatment parameter from the process; means to compare the input data with calculated database; and means to adjust one or more of the amount ultraviolet radiation and the chemical disinfectant added to the flow fluid in response to a difference between the input data and calculated database. There is also described a process for controlling a fluid treatment process configured to inactivate a microorganism in a flow of fluid using ultraviolet radiation and a chemical disinfectant.
US10947124B2	Concentrated aqueous solutions of aluminum chlorohydrate monohydrate A system and method for producing commercial strength solutions of aluminum chlorohydrate are provided. The method includes providing aluminum chlorohydrate monohydrate (ACHMH) powder, heating water to at least 120° F. and less than 200° F., and dissolving at least a portion of the ACHMH powder into the heated water to form the solution of aluminum chlorohydrate. The produced solution of aluminum chlorohydrate from the ACHMH powder has an aluminum oxide concentration ranging from about 18 wt % to about 27 wt %, has a basicity ranging from greater than 74% and less than 83%, and has a freezing point ranging from about 10° F. to about 16° F. The solution may also have an iron content of between about 0 to about 70 ppm as Fe.
US10947119B2	Metal halide crystals having a nanotube structure and methods Provided are organic metal halide crystals having a 1D nanotube structure. The metal halide crystals may have a unit cell that includes two or more face-sharing metal halide dimers. The metal halide crystals also may include organic cations. Methods of forming metal halide crystals having a 1D nanotube structure also are provided.
US10947111B2	Method for frequency trimming a microelectromechanical resonator Embodiments of the present disclosure can include a method for frequency trimming a microelectromechanical resonator, the resonator comprising a substrate and a plurality of loading elements layered on a surface of the substrate, the method comprising: selecting a first loading element of the plurality of loading elements, the first loading element being layered on a surface of a region of interest of the substrate; heating the first loading element and substrate within the region of interest to a predetermined temperature using an optical energy source, causing the first loading element to diffuse into the substrate; and cooling the region of interest to form a eutectic composition layer bonding the loading element and the substrate within the region of interest.
US10947109B2	Semiconductor component and method for producing same A method for producing a semiconductor component is proposed. The method includes providing a housing. At least one semiconductor chip is arranged in a cavity of the housing. Furthermore, an electrical contact of the semiconductor chip is connected to an electrical contact of the housing via a bond wire. The method furthermore includes applying a protective material on the electrical contact of the semiconductor chip and also on a region of the bond wire which is adjacent to the electrical contact of the semiconductor chip, and/or on the electrical contact of the housing and also on a region of the bond wire which is adjacent to the electrical contact of the housing. Moreover, the method also includes filling at least one partial region of the cavity with a gel.
US10947108B2	Micro-electromechanical transducer A micro-electromechanical transducer including one or more moveable members, and a viscoelastic substance having a predetermined viscoelasticity, the viscoelastic substance being adapted to influence the response of the transducer in a predetermined manner. The micro-electromechanical transducer of the present invention may include a MEMS transducer, such as a MEMS microphone, a MEMS vibration sensor, a MEMS acceleration sensor, a MEMS receiver.
US10947104B2	Dispense control system for a refrigerator appliance A dispense control system for a dispensing assembly of a refrigerator appliance and a method for operating the same are provided. The dispensing assembly defines a base plane for receiving a container. A dispense control system includes an emitter for directing a beam of energy toward the container and the base plane and a receiver for detecting a projection of the beam of energy in an image plane of the receiver. The dispense control system may be configured to obtain a measured displacement of the projection when the container is positioned on the base plane, and an actual height of the container or a liquid level within the container may be determined from the measured displacement of the projection.
US10947102B1	Portable beverage container systems and methods for adjusting the composition of a beverage A beverage apparatus, the beverage apparatus being hand-holdable by a user of the beverage apparatus to be portable, can include a beverage chamber housing that includes a chamber for storing a consumable liquid. The beverage apparatus can include a dispensing assembly that includes a receptacle. The receptacle can retain a vessel. The vessel can include an electronic tag and can contain an additive. The dispensing assembly can be operatively controllable by a controller to output the additive from the vessel into the consumable liquid. The beverage apparatus can include one or more sensors, devices, or assemblies that can be used to detect a volume of liquid in the chamber or a liquid level in the chamber. The beverage apparatus can include an apparatus computer processor portion (ACP) and an apparatus database portion.
US10947098B2	Refrigerator and control method thereof Disclosed herein is a refrigerator capable of producing carbonated water and a control method thereof. The refrigerator includes a carbonated water tank to store carbonated water a carbon dioxide gas supply valve to open/close a carbon dioxide gas flow path to guide carbon dioxide gas from a carbon dioxide gas cylinder to the carbonated water tank, and a carbonated water tank pressure sensor to detect an internal pressure of the carbonated water tank.
US10947094B2	Auxiliary brake assembly An auxiliary brake assembly for use in a hoist, is disclosed. The auxiliary brake assembly comprises a pinion, a fastener, and a clutch assembly. The pinion may comprise a mesh gear disposed proximate a respective mesh gear of a rotor gear. The clutch assembly may be disposed between the fastener and the mesh gear. The fastener may be configured to compress the clutch assembly in the event a cable drum of the hoist is free spinning. The compression of the clutch may lock the pinion and the rotor gear and stop the cable drum from spinning freely.
US10947093B2	Remote operation terminal and remote operation system of mobile crane A remote operation terminal T for remotely operating a mobile crane C is configured to include: a mode selection unit 34 for selecting an operation mode corresponding to work of the mobile crane C from a plurality of operation modes; an operation unit 35, 36 for instructing the mobile crane C on operation; and a control unit T1 that, when the operation mode is selected by the mode selection unit 34, assigns the operation corresponding to the selected operation mode to the operation unit 35, 36, and transmits an operation signal from the operation unit 35, 36 to the mobile crane C. Thereby, various operations can be performed by remote operation while securing safety.
US10947089B2	Bottom block assembly A bottom block assembly includes a bottom block defining a cavity and at least one opening passing through a portion of the bottom block. The assembly further includes a plurality of sheaves disposed at least partially within the cavity, each sheave having a central opening. The assembly further includes a sheave pin passing through the at least one opening in the bottom block and the central openings in the sheaves to rotatably couple the plurality of sheaves to the bottom block. The assembly further includes a plurality of captivating frame assemblies to be coupled to the plurality of sheaves, each of the plurality of captivating frame assemblies including a housing and a plurality of rollers rotatably mounted to the housing. Each captivating frame assembly is associated with a corresponding one of the sheaves. The assembly further includes a plurality of wires for coupling the plurality of captivating frame assemblies to the plurality of sheaves. Each wire is reeved around one of the sheaves and reeved through the corresponding captivating frame assembly.
US10947088B2	Elevator vibration damping device An elevator system includes a stationary structure, a first sheave rotationally supported by the structure, a rope supported by the first sheave, and an elevator car supported by the rope. A vibration damping device of the elevator system is positioned at a first termination of the rope, and is configured to reduce vibration waves in the rope, thereby reducing noise in the elevator car.
US10947086B2	Sequence triggering for automatic calls and multi segment elevator trips A computer-implemented method a sequence triggering of a call for an elevator car of an elevator system. The elevator system including a first location device and a second location device. The computer-implemented method including detecting, by the first location device, a signal by the mobile device and detecting, by the second location device, the signal by the mobile device. The computer-implemented method also including automatically executing, by the elevator system, the call for the elevator car in response to the detection by the second location device of the signal subsequent to the detection of the signal by the first location device.
US10947085B2	Sequence triggering for automatic calls and multi-segment elevator trips A computer-implemented method a sequence triggering of a call for an elevator car of an elevator system. The elevator system including a first location device and a second location device. The computer-implemented method including detecting, by the mobile device, a first triggering signal by the first location device and detecting, by the mobile device, a second triggering signal by the second location device subsequent to the detection of the first triggering signal. The computer-implemented method also including automatically executing, by the mobile device, the call for the elevator car of the elevator system in response to the detection of the second triggering signal subsequent to the detection of the first triggering signal.
US10947083B2	Coiled tubing and slickline unit A coiled tubing unit includes a coiled tubing assembly and a slickline assembly sharing an axis of rotation with the coiled tubing assembly. A shaft of the coiled tubing assembly is received by bearings on a slickline drum of the slickline assembly and extends through an interior of the slickline drum. A swivel joint connection is rotatably affixed on an end of the shaft as it exits the interior of the slickline drum, thus allowing for introduction of fluid or cabling into the shaft and into the coiled tubing. The coiled tubing drum and slickline drum can rotate independently and are powered independently of each other. The coiled tubing and slickline assemblies are preferably affixed to a removable module, the removable module being positioned on a skid having a power unit and appropriate controls.
US10947082B2	Winding station having a movable cover unit A winding station of a textile machine for producing cross-wound bobbins includes a base unit, a cover unit, and a bobbin holder configured to hold the cross-wound bobbin. A traversing device is configured to lay a thread in a crosswise manner on the cross-wound bobbin. A thread finding device is configured to find a thread end on the cross-wound bobbin. The base unit at least partially covers the cover unit, and the cover unit is movable with respect to the base unit between a working position for laying the thread and seeking the thread end and a cleaning position for cleaning the winding station. At least portions of the thread finding device are configured on the cover unit. A method is also provided for operating the winding station.
US10947080B2	Apparatus for and method of folding and winding a band of non-woven fabric of a predetermined length The present invention relates to an apparatus and a method for folding and winding a predetermined length of non-woven fabric used for the industrial production of moistened wipes. The apparatus for folding and winding a predetermined length of non-woven fabric from a roll wound on a core is mounted on a countertop, equipped with a housing, provided with a drive unit. Mounted on a hub (1) is a cylinder (2), to which eccentrically attached are rods (3) from which at a certain distance is mounted a linear feed (4). The hub assembly (1) with the cylinder (2) with the rods (3) and the linear feed (4) can be mounted vertically or horizontally.
US10947077B2	Sheet post-processing apparatus and method for controlling the sheet post-processing apparatus According to embodiments, a sheet post-processing apparatus includes a processing tray, a vertical alignment section, a horizontal alignment section and a controller. The controller is configured to control the horizontal alignment section to shift the sheet to a first alignment position a predetermined distance from the center of the processing tray in the sheet width direction, control the horizontal alignment section to align the sheet in the sheet width direction at the first alignment position, and control the vertical alignment section to align the sheet in the conveying direction at the first alignment position, control the horizontal alignment section to realign the sheet at the first alignment position.
US10947076B2	Image forming apparatus to which post-processing apparatus can be connected, image forming system, control method therefor, and storage medium storing control program therefor An image forming apparatus that is capable of reducing influence of a failure on execution of a print job even if a post-processing apparatus that has a sheet stacking unit breaks down. Post-processing apparatuses are connected at a downstream side of an image forming apparatus in a sheet conveyance direction and apply post-processes to the sheet discharged from the image forming apparatus. A specifying unit specifies an available downstream-most apparatus from among the post-processing apparatuses. A setting unit can set a forced discharge mode in which a sheet is discharged to the downstream-most apparatus when the downstream-most apparatus is not provided with a sheet stacking unit. When the forced discharge mode is set, apparatuses at an upstream side of the downstream-most apparatus are controlled so as to discharge a sheet to the downstream-most apparatus and the downstream-most apparatus is controlled so as to discharge the sheet outside the apparatus.
US10947074B2	Note validator transport path centralizer Various embodiments herein each include at least one of systems, assemblies, devices, components, methods, software and firmware for a note validator transport path centralizer, such as may be present in a Self-Service Terminal, e.g., an Automated Teller Machine. One example method embodiment includes receiving a note by a receiving and transport module of a note validator and sensing a lateral positioning of the note on a transport path of the note validator. This method further includes engaging at least one centralizing mechanism to move the note to a medial position on the transport path of the note validator and disengaging the at least one centralizer mechanism upon sensing the note reaching the medial position on the transport path of the note validator. The method may then output the note from the receiving and transport module of the note validator to a note validation module.
US10947072B2	Belt conveying device and image forming apparatus An inadvertent swing of a steering roller is restricted with a versatile configuration. A belt conveying device includes a belt member configured to be stretched around a steering roller and a roller member, and a movement mechanism configured to move the roller member. The roller member is movable to a first position and a second position where the roller member is moved further inward on an inner peripheral side of the belt member than the first position by the movement mechanism. In the movement mechanism, a restriction portion capable of restricting a swinging range of the steering roller more in a case where the roller member is at the second position than in a case where the roller member is at the first position is provided.
US10947068B2	Telescopic plate A telescopic plate includes a sliding rail structure (10), a rotation structure (20), a drive structure (30) including a motor (31), a circulation structure (40) including an upper connection member (41) and a lower connection member (42), and a support frame (50) mounted on the telescopic sliding rail. The sliding rail structure includes a fixed sliding rail (11) and a telescopic sliding rail (12); the rotation structure including a double-groove wheel (21) mounted at one end of the motor; the upper and lower connection members are wound on the double-groove wheel and extend into the fixed sliding rail to fix with the telescopic sliding rail; a positioning bolt (111) is provided on an inner wall at the tail end of the fixed sliding rail; a positioning groove (1211) is provided at the front end of the telescopic sliding rail; the upper and lower connection members pull the telescopic sliding rail to implement sliding of the support frame in the fixed sliding rail; the positioning bolt and the positioning groove are cooperative so that the telescopic sliding rail rotates around the positioning bolt. A motor is used for controlling to slide and rotate the support frame; a rotation angle can be adjusted by means of a remote-control operation so as to meet user requirements.
US10947066B2	Conveying system and method for controlling conveying system A conveying system includes a plurality of carriers and circuitry. The plurality of carriers has a power source generating thrust in accordance with supply of power and moves along a conveying path. The circuitry is configured to execute detection of a collision between the carriers based on an increase in the thrust in the carriers.
US10947063B2	Load port A load port including: a base as part of a wall partitioning a transportation space from an external space; an opening provided to the base; a door configured to open and close the opening and securing a lid to, and releasing a lid from, a container containing contents; and a first seal member for sealing the space between the base and the container. At least some of the container-side end surface of the door is located nearer to the transportation space than the container-side end part of the first seal member. The load port can keep a surrounding space clean when a FOUP is connected to a casing.
US10947060B2	Vertical sequencer for product order fulfillment A product order fulfillment system including a multi-level transport system and a lifting transport system. Each level of the multi-level transport system having a corresponding independent asynchronous level transport system separate and distinct from the asynchronous level transport system corresponding to each other level of the multi-level transport system. Each independent lift axis of the lifting transport system being configured to independently hold at least one case and being communicably coupled to each asynchronous level transport system so as to provide for exchange of the at least one case between each asynchronous level transport system and each independent lift axis. Each independent lift axis is communicably coupled to each other independent lift axis of the more than one lift axis and forms a common output of mixed cases so as to create an ordered sequence of mixed cases in accordance to a predetermined case out ordered sequence.
US10947053B2	Production system for spectacle lenses Disclosed is a production system for spectacle lenses made from spectacle lens blanks, having a left-hand outer transport track, multiple left-hand processing devices which are arranged on the left-hand side next to the left-hand outer transport track, a right-hand outer transport track, and a central transport track which is arranged between the left-hand outer transport track and the right-hand outer transport track. The transport direction of the left-hand outer transport track and the transport direction of the right-hand outer transport track are identical, and the transport direction of the central transport track is opposite to the transport directions of the left-hand outer transport track and the right-hand outer transport track or can be reversed. The multiple right-hand processing devices are arranged on the right-hand side next to the right-hand outer transport track. A processing device pair made of left-hand and right-hand processing devices is paired with a transfer device.
US10947048B2	Positive drive for a spiral conveyor and belt module for a radius or spiral conveyor The present disclosure may be embodied as a belt module for a radius or spiral conveyor. The belt module includes first link ends extending in a direction of belt travel. Each first link end has a transverse opening. Second link ends extend in a direction opposite the first link ends and are configured to interdigitate with the first link ends of an adjacent belt module, and each second link end has a transverse opening defined therein. The transverse openings of the first and/or the second link ends are elongated. The belt modules further include a collapsible tab for contacting a frame member. The collapsible tab is located at a first transverse end of the belt module. In some embodiments, the collapsible tab is configured to engage a drive bar. The belt module may further include a guide tooth on a bottom side of the module for engaging a guide.
US10947046B2	Loading system for palleting mixed products on a target pallet Loading system for palletizing mixed products on a target pallet, having at least two infeed conveyors for the products to be palletized, at least one grab head which is configured to take at least one product from one of the infeed conveyors in a predetermined sequence and to stack it on a loading plate, via which at least one product stack can be transferred to the target pallet, wherein at least two, preferably more product stacks are arranged on the loading plate during stacking and which are arranged at a distance (a) from one another.
US10947044B2	Method and apparatus for storing or retrieving items A method and apparatus are provided for storing and retrieving items to/from a plurality of destinations areas. A storage and retrieval system stores and retrieves items as needed and transfer items from storage locations to transfer locations. A separate picking system conveys the items from the transfer locations to a picking station or an input out station so that the item can be selected.
US10947041B2	Transport system and transport method A transport system includes first and second intrabay overhead tracks, first and second interbay overhead tracks, first and second storages, first and second delivery ports, first and second cranes including first and second runners that run along the first and second intrabay overhead tracks, respectively, first and second masts, and first and second transferors, and an overhead transport vehicle including a runner that runs along the first and second intrabay overhead tracks, a holder, a lifting driver, and a lateral extender.
US10947039B2	Discharge valve A discharge valve for discharging a food product may be arranged at a low point of a vessel. The discharge valve includes a valve body, a valve seat, a valve plug and an arm. The valve plug is attached to a first end of the arm and a second end of the arm is attached to a pivot point that is arranged inside the valve body. The arm is configured to pivot the valve plug between a valve closed position where the valve plug abuts the valve seat, and a valve open position where the valve plug is pivoted away from the valve seat, to a location where the valve plug is positioned at least partly within the valve body.
US10947037B2	Method and apparatus for collapsible container A hollow container or box formed from a roof, a first side (i.e., or first upper and lower sides), a second side (i.e., for second upper and lower sides), a rear side (i.e., or rear upper and lower sides), a door (i.e., or upper and lower door), and a base placing the container or box in a fully assembled position. Unique side and end access doors are provided. Each of the sides are releaseably coupled or hingedly connected to one another and the adjacent sides are hingedly coupled to the base. Upon releasing the sides from one another and rotating each relative to one another in a particular order along various axis rotation, the container or box is transitioned from a fully assembled position into a flat, parallel orientation, fully collapsed position.
US10947033B2	Reduction in stress cracking of films Methods and packages for storing film strips while reducing or eliminating stress cracking during storage, including use of packages having an inner surface made from polymeric materials exhibiting various physical properties and including films and pouches that are annealed.
US10947032B2	Packaging box for liquid crystal panel A packaging box for a liquid crystal panel includes a box and a reinforcing member, the box includes a bottom board and a side frame, and the reinforcing member is fixed on the bottom board. Since the reinforcing member is fixed on the bottom of the box, the supporting strength of the bottom board is enhanced. Thus, the thickness of the box is decreased, which is advantageous to decrease the thickness of the whole stacked pallet and warehousing spaces of logistics.
US10947027B2	Dosing dispenser system A dosing dispenser for a flowable composition includes a housing, a traveler, a plunger, and a driver. The housing defines a chamber, and the plunger is movable within the chamber. The traveler is at least partially within the chamber and configured to selectively position the plunger. The driver is at least partially within the chamber and configured to movably position the traveler relative to the driver. The driver is engaged with the traveler within the chamber.
US10947026B2	Methods and systems for controlling and maintaining the temperature of a drink within a drinking vessel Systems and methods for controlling and maintaining the temperature of a drink are discussed. The system may include a receptacle defining a recess for receiving a drinking vessel. The system may have a stand for holding the receptacle upright. The stand may be releasably attached to the receptacle. The receptacle may include a top end portion, a bottom end portion, an inner wall portion, and an outer wall portion. The top end portion may define a top opening of the recess. A system may include a first receptacle defining a first recess for receiving a drinking vessel. The system may include a second receptacle for receiving a drinking vessel, wherein the second receptacle defines a second recess. The system may include a first stand operable to releasably attach to the first receptacle and the second receptacle.
US10947023B2	Instant noodles container lid Provided is an instant noodles container lid that provides indication according to elapse of time from the start of boiling water process. An instant noodles container lid includes a surface member, an intermediate member, and a seal base member having a sealant layer in order, respectively, from one surface side. The surface member has a printed layer in an area other than a first area. The intermediate member includes a paper layer, a printed layer, a filling layer, and a wax layer in order, respectively, from the one surface side, and the wax layer is in a second area that covers the first area. A first half cut is formed from the surface member into the paper layer, in the first area. A second half cut is formed in the second area from the filling layer into the paper layer in a portion outside of the first area.
US10947017B2	Bucket lid A combination bucket lid and seat permits a user to access contents of the bucket while the user is seated. The lid has a lip for engaging the bucket, and an opening configured to receive a hand of a user for removing the bucket contents. The opening may be selectively covered by a door that is attached to the lid. The door is movable between a closed position and an opened position. The door is configured to cover the opening of the lid in the closed position and uncover the opening of the lid in the open position. The door also may have a pad that allows the user to be comfortable while sitting. More specifically, the door may be attached to the lid by a hinge, or rotatable about an axis of rotation, to selectively cover and uncover the opening.
US10947015B2	Tamper evident cap assembly A tamper evident cap assembly includes an outer cap having an outer cap end wall and an outer cap skirt, and an inner cap having an inner cap end wall and an inner cap skirt. The inner cap skirt has a thread on an inner surface for selectively fastening the cap assembly on a portion of a container. The thread has separations therein. The first and second vertical ratchet teeth of the outer cap and the inner cap, respectively, abut when the outer cap is turned in an application direction to rotate the inner cap and the outer cap together to fasten the inner cap onto the container. When a downward force is applied on the outer cap, the second end teeth on the inner cap engage with the first end teeth on the outer cap applying torque on the outer cap in the removal direction turning the inner cap to release the cap assembly from the container and rupture the tamper evident band.
US10947013B1	Card object carrier A card carrier includes a presentation substrate, a pocket layer connected to an interior side of the presentation substrate, and a notification carrier configured to fit within a receiving pocket. The presentation substrate defines a presentation address window. The receiving pocket is defined by the pocket layer and the presentation substrate. The pocket layer defines an interior display window configured for displaying card object data and is connected to the presentation substrate such that the interior display window is positioned in a top half of the presentation substrate. When the notification carrier is positioned within the receiving pocket, an address on the notification carrier is visible through the presentation address window.
US10947011B2	Drinking or eating vessel There is provided a drinking or eating vessel comprising an inner surface that defines a volume for receiving liquid or solid food and an outer surface that supports a polymeric coating and a decorative layer; wherein the polymeric coating comprises a polymer formed by curing a coating mixture on the outer surface of the drinking or eating vessel, said coating mixture comprising a matting agent; wherein the polymeric coating has an inner surface in contact with the drinking or eating vessel and an outer surface exposed to contact by a user of the vessel; and wherein the decorative layer forms a diffuse layer within the polymeric coating. Also provided are corresponding processes for producing the drinking or eating vessel.
US10947010B2	Stackable bucket system A stackable bucket system for carrying multiple substances in different containers at the same time while holding a single handle. The stackable bucket system includes a first container and a second container, wherein the second container is adapted to receive the first container therein and removably couple thereto, with the second container being larger than the first. Each container comprises a base and a perimeter wall ending in a rim at an open top. Handles are included on each container and are pivotally affixed to opposing sides thereof. The handle of the second container is wider than that of the first container and is adapted to fit over top of the handle of the second container. A flange protruding outward from the perimeter wall of the containers is adapted to rest flush against the rim of the open top when of the adjacent container when installed.
US10947008B2	Detachable pallet The invention relates to a detachable pallet which comprises a plurality of slides and a plurality of cross-members, wherein the slides comprise anchoring elements, both rigid stops and flexible stops, which contribute to attaching the cross-members to the slides, all in cooperation with tongues and grooves provided in the sides of the cross-members, which are inserted into one another creating a solid, robust joint and a complete load surface. The pallet can also have a tie rod joined to the bottom of the slides, securing same and providing greater robustness to the assembly, allowing it to be used on roller lines.
US10947004B1	Dual use box A box comprising: a side panel; a covering top panel connected to the side panel by a fold line, the covering top panel comprising an overlapping portion comprising: a primary sealing flap, the primary sealing flap comprising a primary adhesive; a secondary flap connected to the primary sealing flap by a perforated line, the secondary flap comprising a distal end and a proximal portion that is proximal the side panel relative to the distal end, the distal end comprising a secondary adhesive, the distal end joined to the proximal portion by a tear strip.
US10946998B2	Vertical packaging machine Vertical packaging machine for generating packages from a film that according to one embodiment includes a film feeder and a forming tube with a longitudinal axis. The forming tube configured to impart a tubular shape to the film. The machine is configured for incorporating a longitudinal tool for longitudinally sealing the longitudinal ends of the tubular-shaped film together and generating a film tube. The machine also includes a module for moving the film tube, and a transverse tool for transversely sealing and cutting the film tube. The module is configured for rotating with respect to the longitudinal axis of the forming tube, being arranged in different operating positions, such that it allows arranging the longitudinal tool required in different positions for generating packages having different topologies and/or different sizes without the need of moving the transverse tool.
US10946996B2	Transfer wheel between a lollipop forming and a lollipop wrapping unit The present invention relates to a lollipop production and down-stream processing apparatus (1) with a forming unit (2) and a down-stream processing unit (4) and a transfer wheel (3) in between the units (2,4) which rotates around a first axis (26) and which comprises a multitude of grippers (6) which releasably hold the stick of the lollipop and which rotate relative to the transfer wheel (3) around a second axis of rotation (27) parallel to the first axis of rotation (26). The present invention further relates to a method to transfer a lollipop from a forming unit (2) to a down-stream processing unit (4) by means of a transfer wheel (3) which rotates around an axis of rotation (26) and which comprises a multitude of grippers (6), each gripping the stick of a lollipop and taking it out of the holding means of the forming unit (2) and handing it over to the holding means of a down-stream processing unit (4).
US10946989B2	Method of and apparatus for packaging snack food chips A method of packaging snack food chips, the method comprising the steps of: (a) providing a plurality of snack food chips as a shingled assembly of the snack food chips; (b) enclosing the shingled assembly within an elongate packaging container; (c) vibrating the shingled assembly supported so as to cause the snack food chips sequentially to fall from a free output end into the elongate packaging container while progressively translationally separating a closed end and the free output end to form a shingled stack extending away from the closed end; and (d) during at least a part of step (c), rotating the elongate packaging container so that the closed end is lowered while decreasing an angle of inclination such that the shingled stack is being progressively formed.
US10946982B2	Systems and methods for roof-top UAV delivery A system and method for receiving a package from an unmanned aerial vehicle at a rooftop package receiving station and securely holding the package at the package receiving station. The recipient, using a computing device, may prompt the package receiving station to deliver the package from the rooftop to a delivery location.
US10946977B2	Method and system for integrating offboard generated parameters into a flight management system Methods and systems are provided for integrating aircraft flight parameters generated by an offboard portable electronic device (PED) into an onboard flight management system (FMS). The method comprises selecting the aircraft flight parameters to be generated by the PED for use by the FMS. The current flight data is accessed for the aircraft with the FMS and providing the current flight data to the offboard PED. The rules for the aircraft flight parameters are computed with the offboard PED based on the current flight data for the aircraft and transmitted to a flight management (FM) adapter. The FM adapter confirms that the rules for the aircraft flight parameters comply with operational limits of the aircraft and then translates the rules of the aircraft flight parameters to aircraft operational targets for use by the onboard FMS. The aircraft operational targets are then loaded from the FM adapter into the FMS.
US10946974B2	Monolithic lipskin and method of fabrication An aircraft nacelle and method of fabricating a monolithic lipskin of the nacelle. The nacelle may include a fan cowl, a bulkhead, and the monolithic lipskin. The lipskin may be formed by spin-forming or explosive forming an annularly-shaped plate onto a mandrel, and machining or chemically-milling integrated stiffeners or other protrusions and attachment tabs into an inner mold line (IML) of the lipskin. The machining or chemical milling may occur before or after the spin-forming or explosive forming. The stiffeners may have a spiral or circumferential configuration. An attachment tab extending from the IML may attach to the bulkhead, such that an outer mold like (OML) of the lip-skin is not disrupted by mechanical fasteners attaching the lipskin to the bulkhead.
US10946973B2	System and method for providing end-use specific customization of gas turbine engine operation A system and method provide aircraft-specific customization of gas turbine engine operation. The system includes a gas turbine engine, a first processing unit, and an engine controller. The first processing unit is configured to selectively transmit an activation key. The engine controller is in operable communication with the first processing unit and the gas turbine engine. The engine controller is configured to receive the activation key transmitted by the first processing unit and is operable, upon receipt of the activation key, to: verify the received activation key is correct, enable operational parameters in the gas turbine engine and the engine controller when the received activation key is correct, and control the gas turbine engine using the enabled operational parameters.
US10946970B2	Systems for removal of parachute assembly head restraints A system for translating a head restraint of a parachute assembly away from a head of an occupant supported by the parachute assembly may comprise a chord coupled to the head restraint and at least one of a control line configured to manipulate a canopy of the parachute assembly or a handle coupled to the control line.
US10946969B2	Split ventilation systems A ventilation system, aircraft, and method. The ventilation system includes a first conduit in fluid communication with a first air source in the aircraft to direct a fluid flow from the first air source. The ventilation system also includes a first branch in fluid communication with the first conduit and a first outflow point, the first branch including an active air mover to move the fluid flow toward the first outflow point. The ventilation system further includes a second branch that is separate from the first branch and in fluid communication with the first conduit and a second outflow point, the second branch including a passive air mover to move the fluid flow to toward the second outflow point.
US10946966B2	Multi-panel privacy screen assembly A multi-panel privacy screen assembly adapted to be deployed between laterally-adjacent passenger seats. The assembly includes an overhead beam having a plurality of tracks, a plurality of hanging panels, a plurality of coupling members suspending each of the plurality of hanging panels from the overhead beam, each coupling member coupled to one of the plurality of hanging panels, to one of a plurality of driven cables, and having rollers rollable along at least one of the plurality of tracks, and a drive mechanism including an intermittent gear assembly operable for driving the plurality of driven cables to move the plurality of hanging panels along at least one of the plurality of tracks according to predetermined deployment sequence.
US10946965B2	Gap accessary device for elevated roller rails The invention is a gap accessary device for elevated roller rails disposed on a platform floor. The device includes a housing, fingers, tangs, roller support structures, rollers, a first curved truncated inclined plane, and a second curved truncated inclined plane. The device allows cargo to enter a platform without catching on the platform threshold and requires less effort to load cargo onto a platform with elevated roller rails.
US10946962B2	Blended wing body aircraft A blended wing body aircraft wherein at least each profile section corresponding to the normalized half-span values from 0 to 0.2 has a thickness ratio having a nominal value within the range set forth in Table 1. Also, a blended wing body aircraft wherein at least each profile section corresponding to the normalized half-span values from 0.15 to 0.3 has a normalized chord having a nominal value within the range set forth in Table 1, and wherein a ratio between a maximum thickness of the center body and the chord length along the centerline has a nominal value of at least 16%. Also, a blended wing body aircraft wherein a region of the aircraft defined by normalized half-span values from 0.1 to 0.2 has a normalized chord having a dimensionless rate of change from −3.5 to −5.1, and a thickness ratio having a rate of change from −0.27 to −0.72.
US10946959B2	Drone configured for multiple uses Disclosed is a drone configured for multiple uses. The drone may include a body and a sensor configured to be attached to the body. Further, the drone may include a plurality of arms configured to be attached to the body. Further, a first end of an arm of the plurality of arms may be attached to the body at a first movable joint. Further, the arm may include a first part connected to the first movable joint. Further, the arm may include a second part attached to the first part at a second movable joint. Further, the arm may include a powered rotor including a shaft configured to provide rotatory motion. Further, the powered rotor may be attached to one or more of the first part and the second part. Further, the drone may include a plurality of propeller blades attached to the shaft.
US10946952B2	Aircraft landing gear assembly An aircraft landing gear assembly including a structural load bearing beam arranged, in use, to react torsional loads applied to it. The beam has a tubular box section main body having four straight sidewall portions, adjacent sidewall portions being orthogonal to one another and connected by rounded corner portions. Each corner portion has a radius of between 10% and 40% of the width and/or height of the tubular box section main body.
US10946948B2	Slide and rotating cockpit door and method A door assembly for a vehicle. The door assembly includes a door frame, a door panel, a rotating strut, and a linear door guide. The door opens and closes through a combination of rotating and sliding motion, which minimizes the required operational footprint. The strut is mounted on the door panel such that the strut is hidden from view when the door is in an open position.
US10946947B1	Oar capable of bailing water An oar capable of bailing water includes a rod and an oar blade disposed at one end of the rod. The rod includes an outer tube and an inner tube that are insertedly connected to each other to form a pump structure capable of performing a telescopic movement. A fixing device is provided at the junction of the outer tube and the inner tube. The rod has an accommodating room therein. The accommodating room is provided with a piston that can slide along the accommodating room with the telescopic movement of the rod. Another end of the rod, opposite to the oar blade, is formed with a bail opening. A passage is defined between the bail opening and the accommodating room to communicate with each other, so that the bail opening can bail water when the piston is moved.
US10946946B2	Sail construction Sail construction comprising foldable sail supports, a crossbeam, a holder, a sail, a bottom holder, ropes and a block and tackle system. The sail can be a self-inflatable sail designed similarly to paragliders, partially or fully inflatable.
US10946944B2	Modified CO2 cycle for long endurance unmanned underwater vehicles and resultant chirp acoustic capability A carbon dioxide cycle power generation system includes a first carbon dioxide storage configured to store a first portion of carbon dioxide and a second carbon dioxide storage configured to store a second portion of the carbon dioxide. The carbon dioxide cycle power generation system also includes a generator configured to generate electrical power based on a flow of at least part of the carbon dioxide between the first and second carbon dioxide storages. The carbon dioxide cycle power generation system is configured to cycle between different underwater depths in order to employ water pressure and/or water temperature in creating the flow of the at least part of the carbon dioxide through the generator. The second carbon dioxide storage includes an annular region surrounding a central region, where the annular region has a variable internal volume configured to receive at least part of the second portion of the carbon dioxide.
US10946942B2	Fin stabilizer A vessel hull stabilization system includes a housing having a rotatable shaft mounted thereto, the shaft configured to connect to a fin such that the fin is located on an outside of the vessel hull and the housing is located on an inside of the vessel hull. A drive system is mounted to the housing and includes a motor and a drive element. The motor is connected to a central shaft of the drive element and an outer element of the drive element is connected to the fin shaft. The drive element includes a plurality of teeth positioned between the outer element and the central shaft such that when the motor rotates the central shaft, the plurality of teeth oscillate in a direction perpendicular to an axis of the central shaft to interact with and rotate the outer element. A controller receives sensor readings to determine control signals to send to the motor(s) to impart rotation of the fin.
US10946941B2	Process for controlling the roll and/or pitch motion of a ship with null or low ship speed A process is described for controlling the roll motion of a ship, with null or low ship speed, through at least one stabilizing fin. The process comprises the following steps: starting the movement of the stabilizing fin when the roll motion starts; impressing a motion law of the stabilizing fin depending on the roll rate; and ending the movement of the stabilizing fin when the roll motion ends.
US10946940B1	Small ship A ship including at least two hull sections spliced together along the axial direction of the ship. The two adjacent hull sections are connected through a splicing structure. The splicing structure includes a first matching structure and a second matching structure. The first matching structure includes a protrusion and a groove that are in a vertical inserting fit. The second matching structure includes a fixed base and a rotating base for rotating to press the fixed base. The hull sections of the present invention are stable to connect and convenient to disassemble and assemble.
US10946939B1	Watercraft having a waterproof container and a waterproof electrical connector A watercraft and a waterproof electronics container are provided. The watercraft includes a flotation portion. A strut is removably affixed to a portion of the watercraft. A first connector portion is mounted to the upper end of the strut. A waterproof electronics container includes a second connector portion is disposed such that the second connector forms at least one electrically conductive pathway with the first connector portion when both are affixed to the watercraft. The waterproof electronics container is removably affixed to the said watercraft. In one aspect, the waterproof electronics container houses a power source capable of powering an electric motor that propels the watercraft.
US10946938B2	Coupling system for transfer of hydrocarbons at open sea A coupling system for fluid transfer between a bow area of an elongated vessel and a hydrocarbon delivery installation at open sea. The system includes a support frame for suspending the system to the vessel and a fluid receiving tube segment fixed to the support frame comprising a coupling device arranged at a first end of the tube segment and that establishes a leakage free coupling with a hose valve. The system further includes a remotely controlled drive system that simultaneously exerts a transverse force generating pendulum movements of the coupling device in the transverse plane, a longitudinal force generating pendulum movements of the coupling device in a longitudinal plane, and a rotational force generating rotational movement of at least part of the coupling device iteratively adjusting the rotational position of the at least part of the coupling device by regulating the rotational force.
US10946937B2	Auto-releasable new danger mark buoy A buoy system according to one embodiment of the present invention includes a buoy body configured to provide buoyance; a fixing belt configured to fasten the buoy body to a ship structure; an auto-release unit configured to release the buoy body to be buoyed by releasing the fixing belt when a predetermined water pressure is reached; and an auto-reel chain box fixed to the ship structure, being opened in conjunction with releasing of the fixing belt, and including a chain which is reeled out when the buoy body is buoyed, wherein the auto-reel chain box comprises: a weight provided in the auto-reel chain box and being movable upward and downward according to a water pressure and buoyance; a pulley provided in the auto-reel chain box, having the chain wounded thereon and a plurality of teeth on an outer circumferential surface thereof; and a shaft having one end connected to the weight and the other end engaging with the teeth to fix the pulley and provided to be rotatable around a portion fixed in the auto-reel chain box.
US10946930B2	Bicycle controller A bicycle controller controls a motor in accordance with the riding environment of a bicycle. The bicycle controller includes an electronic control unit that is configured to control a motor that assists in propulsion of a bicycle in accordance with a manual driving force. The electronic control unit is further configured to control an output torque of the motor to be less than or equal to a predetermined torque. The predetermined torque is changed in accordance with an inclination angle of the bicycle.
US10946927B2	Shock absorber A shock absorber includes a cylinder including a working chamber therein; a rod configured to be axially movably inserted into the cylinder; and a plurality of tanks configured to be integrally attached to the cylinder, wherein an interior of one of the tanks is comparted into a liquid chamber configured to be communicated with the working chamber and filled with liquid and an air chamber filled with gas, and a sub-air chamber configured to be communicated with the air chamber is formed in the other tank.
US10946926B2	Multipiece handlebar assembly A multipiece handlebar assembly, method of assembly and kit are disclosed. The multipiece handlebar assembly, method and kit includes a first handlebar section having a first grip end spaced apart from a first handlebar mounting end and a second handlebar section having a second grip end spaced apart from a second handlebar mounting end. An interjoining feature is at the first and second handlebar mounting ends, wherein the interjoining feature on the first handlebar mounting end is removably secured to the interjoining feature on the second handlebar mounting end. At least one removably secured attachment feature is secured through the interjoining feature.
US10946922B2	Ride-on toy vehicle configured to tilt and drift Embodiments of the present invention relate to a battery powered ride-on toy vehicle. The ride-on vehicle includes a main body, a front wheel assembly, and a steering assembly. The front wheel assembly is angularly offset from the main body so that steering the vehicle into a turn with the steering assembly creates a camber angle in the wheels of the front wheel assembly and tilts the main body into a turn. The ride-on vehicle may also include a rear wheel assembly and a drive assembly configured to drive any wheels included in the front wheel assembly and the rear assembly. The toy vehicle can also drift through turns while tilting into the turn.
US10946921B2	Saddle riding vehicle A saddle riding vehicle includes: a pair of left and right seat rails disposed below a seat for a passenger; a battery disposed below the seat; and an ECU for controlling a drive source of the vehicle, wherein when viewed from above, the battery and the electronic control unit are arranged side by side in a vehicle width direction between the left and right seat rails.
US10946918B2	Body cladding for a motor vehicle, and motor vehicle A body cladding for a motor vehicle, in particular for a single-track vehicle, is provided. The body cladding includes first and second cladding parts movable relative to one another, such that the second cladding part is arrangeable in at least first and second positions relative to the first cladding part. When the second cladding part is in an open state of the body cladding relative to the first cladding part, a storage space is formed between the first and second cladding parts. The body cladding may be provided with a latch for latching the second cladding part in at least one of the open state, a closed state and at least one intermediate state between the open and closed states. The invention further relates to a motor vehicle having such a body cladding.
US10946917B2	Seat frame structure for saddle riding vehicle A seat frame extends rearward from a main frame, and the seat frame is a casting divided into right and left two parts, and the seat frame includes an upper cross member and a lower cross member, and the upper cross member and lower cross member couple divided left and right left side frame half body and right side frame half body one another, and the upper cross member and lower cross member are each fastened to the left side frame half body and right side frame half body with fastening members, and a seat is located above the one upper cross member, left side frame half body, and right side frame half body, and the lower cross member faces the upper cross member.
US10946911B2	Multi-material track pad for a continuous track assembly A multi-material track pad for a continuous track assembly is disclosed. The track pad may include a body with a ground-engaging surface, wherein the body is formed of a metal material with a first hardness; a roller-engaging surface, wherein the roller-engaging surface is formed of a ceramic material with a second hardness that is greater than the first hardness; and a sprocket-engaging surface formed of the ceramic material.
US10946907B2	Aerodynamic curtain assembly for a tank trailer An aerodynamic curtain assembly for use with a tank trailer illustratively includes a front nose assembly, and opposing first and second side assemblies. The front nose assembly illustratively includes a front support coupled to the tank trailer, and a flexible air deflector screen coupled to the support and extending arcuately from a first upright supported by a first side of the tank trailer to a second upright supported by a second side of the tank trailer. Each of the side assemblies illustratively includes an upper support member, a lower support member, an upper coupler securing the upper end of a flexible air deflector screen to the upper support member, and a lower coupler securing the lower end of the flexible air deflector screen to the lower support member.
US10946900B2	Vehicle body front structure Provided is a vehicle body front structure capable of ensuring both driver visibility and collision performance. This vehicle body front structure comprises: a front pillar which has an A-pillar, an A′-pillar located behind the A-pillar, and a lower frame portion connecting the lower ends of the A-pillar and A′-pillar; and a top-side upper member which is disposed above a wheelhouse and connected to a lower-frame-portion upper member connecting portion. Ridge lines are formed across the upper member connecting portion, the lower frame portion, and the A′-pillar.
US10946899B2	Vehicle framework structure A vehicle framework structure includes: a framework body portion extending in a vehicle front-rear direction in a vehicle end portion in a vehicle width direction, the framework body portion forming a closed section by an inner panel constituting an inner part of the framework body portion in the vehicle width direction and an outer panel constituting an outer part of the framework body portion in the vehicle width direction; and a reinforcing member placed inside the closed section of the framework body portion, the reinforcing member including a body portion inclined from the vehicle front-rear direction and provided over the inner panel and the outer panel, and a flange portion extending from an outer peripheral edge of the body portion and joined to the inner panel and the outer panel.
US10946898B2	Close coupled four rail front structure system transferring compressive loads into a single center torsion/compression member A system for providing structural transmittal of force through a vehicle body of a mid-engine vehicle is provided. The system includes an elongated single member torsional box spanning a passenger compartment from a vehicle-forward portion of the passenger compartment to a vehicle-rearward portion of the passenger compartment, parallel to a longitudinal axis of the vehicle body, and laterally centered upon a longitudinal centerline of the vehicle body. The system further includes four rails in a vehicle-forward position relative to the elongated single member torsional box, parallel to the longitudinal axis of the vehicle body, and offset from the elongated single member torsional box. The system further includes four diagonal support members, each diagonal support member being connected at a first end to one of the four rails and at a second end to the elongated single member torsional box.
US10946897B2	System and methods for steering control in assisted vehicle operation A vehicle system comprises a hitch ball mounted on a vehicle and a steering system configured to steer the vehicle. The system further comprises a controller configured to identify a coupler position of a trailer and control a motion of the vehicle at a rate aligning the hitch ball with the coupler position. In response to the rate below a speed threshold, the controller activates a standstill mode suspending a steering control of the steering system.
US10946896B2	Off-road front suspension system A suspension is provided for coupling a front wheel with a chassis of an off-road vehicle. The suspension comprises upper and lower suspension arms that each includes two inboard mounting points to the chassis and one outboard rod-end joint to a spindle assembly coupled with the front wheel. A ball comprising each outboard rod-end joint is fastened by way a bolt between a pair of parallel prongs extending from the spindle assembly. The upper suspension arm is configured to facilitate coupling a strut between the lower suspension arm and the chassis. A steering rod is coupled with the spindle assembly by way of a steering rod-end joint that is disposed forward of a drive axle, thereby decreasing leverage of the front wheel on the steering rod and substantially eliminating bump steer that may occur due to rough terrain.
US10946892B2	Electric power steering apparatus having increased number of sensor signals for safety enhancement The present disclosure relates to an electric power steering apparatus. An embodiment of the present disclosure provides an electric power steering apparatus including a three-channel torque sensor, a three-channel motor position sensor, and a single-wound BLAC motor, and an ECU configured to control steering.
US10946890B2	Steering control unit Provided is a steering control unit for improving influence of fluctuations in an estimated electrical angle on steering feel. A steering control unit includes a microcomputer that performs sensorless control of the driving of a motor by using an estimated electrical angle estimated by calculation. The microcomputer calculates the estimated electrical angle from a value that is obtained by selectively accumulating a first additional angle or a second additional angle. The microcomputer adjusts a vibration component of fluctuations in the estimated electrical angle by varying the amount of change in the first additional angle and the second additional angle.
US10946887B2	Steering device and cargo handling vehicle A cargo handling vehicle includes a universal joint that allows an upper shaft to swing with respect to a lower shaft around a predetermined horizontal axis, a column tube that covers an outer periphery of the upper shaft, and a lockable gas spring that supports the upper shaft via the column tube. The gas spring is disposed under the column tube and connects a cowl with the column tube. The column tube has a cowl backing bracket that is disposed on a side of the universal joint and connected to the cowl, and the cowl supports the cowl backing bracket swingably around the horizontal axis.
US10946886B2	Sled transport apparatus A sled transport apparatus for transporting people and supplies on sand and snow includes a sled body having a bow, a stern, a starboard side, a port side, a bottom, an upper perimeter, and a cavity. A divider wall is coupled to the sled body and extends from the starboard side to the port side and from the bottom to the upper perimeter. The divider wall forms a cooler receptacle within the cavity from the divider wall to the stern that is configured to receive a cooler. A seat bottom is coupled to the sled body adjacent the divider wall and extending from the starboard side to the port side and toward the bow. A towrope is coupled to the sled body.
US10946879B2	Rail fracture detection device The rail fracture detection device detects a rail fracture in a section provided with the track circuit by determining presence or absence of a rail fracture and determining presence or absence of a train on a rail by using information on whether a relay of the track circuit is activated or deactivated and information on a current value of current flowing in the track circuit.
US10946872B2	Vehicle control device In the present invention, a short-term route (provided at a timing for starting automatic driving) for automatic driving control that uses local environment map information generated constantly by a local environment map generation unit is generated continuously even when automatic driving is not set to an on state by an automatic driving switch. As a result, it is possible to instantly control the automatic driving of a vehicle by the continuously generated short-term route after transitioning to the on state of the automatic driving switch.
US10946865B1	Fault isolation, prognosis, and mitigation for vehicle component electrical power circuit A power circuit includes a power source and a plurality components that connect the power source to a subsystem of a vehicle. A fault detection module receives voltages at an output of the power source and at an input of the subsystem and current drawn by the subsystem, and distinguishes between a power source failure, a permanent and an intermittent disconnection of one of the components from the power source, and a loose connection between the power circuit and the subsystem or corrosion of one of the components, based on analyses of the voltages and the current. A fault mitigation module mitigates the first two faults by switching to a different power source in the vehicle to supply power to the subsystem, and mitigates the third and fourth faults by reducing the power consumed by the subsystem and by generating a warning regarding the intermittent disconnection or loose connection.
US10946864B2	Apparatus and method for fault diagnosis and back-up of advanced driver assistance system sensors based on deep learning An apparatus for fault diagnosis and back-up of advanced driver assistance system sensors based on deep learning, the apparatus including: an individual sensor diagnosis unit configured to quantitatively evaluate a reliability of an output result of each sensor at each moment on the basis of a model for an output of each sensor under a normal operation; an inter-sensor mutual diagnosis unit configured to extract shared representation between the sensors and quantitatively evaluate a normal-operation reliability of the output result of each sensor on the basis of the extracted shared representation; and an integrated diagnosis unit configured to quantitatively evaluate a final reliability of each sensor on the basis of output results of the individual sensor diagnosis unit and the inter-sensor mutual diagnosis unit.
US10946863B2	Wheel load estimation method for four-wheel drive vehicle A wheel load estimation method of a four-wheel drive vehicle driven by a rotational driving device comprises a correlation relationship setting step for previously setting a correlation relationship between a total weight and at least one of the front wheel load and the rear wheel load by variously changing a movable load of the vehicle, a total vehicle weight computation step for calculating a current total vehicle weight from an output torque of the rotational driving device and a longitudinal acceleration of the vehicle corresponding to the output torque, and a wheel load estimation step for estimating the wheel load of at least a driving wheel from the correlation relationship and the total vehicle weight.
US10946856B2	Vehicle drive system Provided is a vehicle drive system capable of suppressing a feeling of acceleration drop and free running, thereby improving vehicle riding comfort. The vehicle drive system includes: an internal combustion engine for driving a primary drive wheel; a stepped variable transmission; an assist motor for driving a secondary drive wheel; and a motor control device for controlling the assist motor, wherein the stepped variable transmission is a seamless-shift transmission configured such that a drive force to be transmitted therethrough is interrupted during shifting down, but not substantially interrupted during shifting up, and the motor control device is operable, during the shifting down by the stepped variable transmission, to cause the assist motor to generate a drive force to compensate for the interruption of the drive force.
US10946853B2	Drive force control system for hybrid vehicles A control system for hybrid vehicles to prevent a reduction in a brake force when an electrical input to a battery is restricted. A controller is configured to execute a regeneration control to deliver a regenerative torque resulting from operating second motor as a generator to the drive wheels, and an engine brake control to deliver a brake torque resulting from a power loss of an engine to the output member. The controller is further configured to select an HV-Lo mode when an input power allowed to accumulate in the battery is smaller than a threshold power.
US10946851B2	Pump arrangement for a hydraulic unit having a pump piston In a pump arrangement for a hydraulic unit of a vehicle brake system having a pump housing and a pump piston which is guided so as to be displaceable axially back and forth in the pump housing, a damping element is provided radially between the pump piston and the pump housing. The damping element damps vibrations of the pump piston which occur during an operation of the pump arrangement.
US10946850B2	Brake cylinder maintaining valve A brake cylinder maintaining system includes a main valve comprising a first diaphragm, a second diaphragm, and a valve member, with the first diaphragm having a reference pressure on one side of the first diaphragm and a brake cylinder pressure on an opposite side of the first diaphragm. The second diaphragm having a brake cylinder pressure on one side of the second diaphragm with the first diaphragm configured to move between a first position and a second position based on a differential between the reference pressure and the brake cylinder pressure. The valve member is configured to place a brake cylinder in fluid communication with a brake pipe when the first and second diaphragm are each in the second position and configured to isolate a brake cylinder from a brake pipe when the first diaphragm or the second diaphragm are in the first position.
US10946846B2	Electric brake system and control method thereof Disclosed herein is an electronic brake system and a method for controlling the same are disclosed. The electronic brake system includes a master cylinder for discharging oil according to displacement of a brake pedal, a pedal displacement sensor sensing brake pedal displacement, a simulation apparatus providing pedal pressure responsive to the sensed pedal displacement, a hydraulic pressure supply unit for generating hydraulic pressure using a motor that operates based on the sensed pedal displacement, a hydraulic circuit for supplying the hydraulic pressure generated from the hydraulic pressure supply unit to the caliper, a cut valve positioned between the master cylinder and the hydraulic circuit for transmitting or blocking the hydraulic pressure discharged from the master cylinder, and a controller for blocking at least one of the cut valve and braking control with a target pressure according to a pressure in the simulation apparatus when the simulation apparatus fails.
US10946835B2	Method for controlling access to a vehicle according to different strategies A method for controlling access to a vehicle, the vehicle being equipped with an access module and a keypad, an user having a portable device configured to communicate with said access module, the access module being designed to determine a relative position of the portable device with respect to the vehicle, the keypad being positioned outside the vehicle, wherein when the access module detects that the portable device is inside the vehicle and is in an inactive state, wherein said portable device is unable to authorize user access to the vehicle and start of the vehicle, then vehicle unlocking is authorized by a multiple switch operation in a predetermined sequence on the keypad, and wherein after vehicle unlocking, the access module puts the portable device in an active state, wherein said portable device is able to authorize user access to the vehicle.
US10946834B2	Relay device, storage medium storing program for relay device, and control method of relay device In a system that enables a person who possesses a portable device in which enablement data as data that permits operation of a vehicle is stored, to operate the vehicle, a relay device is provided for relaying the enablement data from a center server that issues the enablement data of the vehicle, to a portable device of a person scheduled to operate the vehicle. The relay device includes an obtaining unit that obtains the enablement data of the vehicle from the center server, a temporarily storing unit that temporarily stores the enablement data obtained by the obtaining unit, in a storage device, and a transmitting unit that sends the enablement data stored in the storage device, to a portable device used by a person in charge of operation of the vehicle.
US10946829B2	Wrap around seatbelt A vehicle seat and safety assembly includes a seat cushion, a seatback, and a wraparound seatbelt system to restrain an occupant in rear, side and rollover crashes. The seat cushion is connected to a vehicle floor. The seatback is connected to the seat cushion. The wraparound belt has a first strap end, a second strap end, and a strap, net or supporting body extending between the first strap end and the second strap end to direct restraining forces from an occupant through the seat to the vehicle floor or structure. The strap, net, or supporting body extends at least partially through or is integrated with the seatback and may incorporate pretensioning, load-limiting and other features to increase and control occupant restraint in non-frontal crashes.
US10946828B2	Multi-layered tether An airbag assembly includes a base and an airbag extendable from the base to a flat position prior to inflation. A tether is elongated along an axis from a first end of the tether attached to the base to another end of the tether attached to the airbag in the flat position. A reinforcement is elongated along the axis in the flat position state and attached to the tether. The reinforcement has a greater torsional rigidity about the axis than the tether.
US10946827B2	Vehicle occupant protection device A vehicle occupant protection device includes: a three-point seatbelt designed to be worn so as to cross the body of an occupant sitting in a seat of a vehicle; a force limiter that applies tension to the three-point seatbelt; an airbag device having an airbag designed to deploy in front of the upper body of the occupant sitting in the seat so as to support the upper body and head that are going to be thrown forward, the airbag having an upper-side portion, an outer-side portion, and an inner-side portion capable of deploying at different pressure levels; a controller that activates the force limiter and the airbag device upon a collision; and an occupant identification device that identifies the physique of the occupant sitting in the seat. The controller changes deployment of each portion of the airbag in accordance with the identified physique.
US10946826B2	Vehicle seat and airbag A system includes a seat back including a housing having a chamber, a frame in the chamber and deployable from the housing above the seat back, an airbag supported by the frame, and a pyrotechnic device in fluid communication with the chamber.
US10946825B2	Airbag assembly An assembly includes a front console. The assembly includes a body having a reaction surface and supported by the front console. The assembly includes an actuator connected to the body, the body movable by the actuator to a deployed position. The assembly includes an airbag supported by the front console and inflatable to an inflated position that abuts the reaction surface. The assembly includes an inflator connected to the airbag.
US10946824B2	Side underride guard A side underride system configured to be coupled to a trailer is provided. The side underride system includes a support system, including a brace system and a cable, configured to be positioned below the trailer to provide side underride protection. The brace system includes a plurality of cross-braces that each extend across a width of the trailer and are spaced apart at intervals along a length of the trailer. The cable is configured to extend across the intervals between the cross-braces.
US10946818B2	Vehicular circuit body A vehicular circuit body includes a trunk line that includes a power source line and a communication line and is routed in a vehicle body, and a plurality of control boxes that are disposed in a distribution manner along the trunk line. In a vehicle, a first power source supplies power to an accessory mounted on the vehicle and a second power source supplies power which is higher in voltage than the power of the first power source to a drive source of the vehicle. The vehicular circuit body further includes a voltage drop unit that reduces the voltage of the power supplied from the second power source, to the voltage of the power of the first power source. To the power source line of the trunk line, the power from the first power source is supplied, and the power from the second power source is supplied through the voltage drop unit.
US10946815B1	Vehicle badge assembly A vehicle badge system includes a housing that defines an opening and an aperture proximate the opening. The housing defines a light-transmissive feature on a side thereof. A lens is coupled to the housing proximate the opening. The lens defines at least one grating. An image-based assembly defines a sensor field to obtain data. The image-based assembly defines a projector field to display a projected image. A first light source is configured to direct light through the light-transmissive feature. A second light source is configured to direct light through the lens. The at least one grating is configured to diffract the light emitted from the second light source.
US10946813B2	Vehicular vision system with forward viewing camera module A vehicular vision system includes a camera module having a housing that houses at least (i) electronic circuitry disposed at a main printed circuit board (PCB) and (ii) an imager assembly. The imager assembly includes an imager, an imager PCB and a lens barrel. Electronic circuitry is disposed at an upper side and at a lower side of the main PCB. The lower side of the main PCB faces a lower housing portion and the upper side of the main PCB faces an upper housing portion. A flexible cable electrically connects electronic circuitry disposed at the imager PCB with electronic circuitry disposed at the main PCB. An electronic component of electronic circuitry disposed at the main PCB is in thermal conductivity with a thermal element, which is in thermal conductivity with the lower housing portion to enhance heat transfer from the electronic component to the lower housing portion.
US10946812B2	Method of assembling vehicular camera with fastenerless lens attachment A method for assembling a vehicular camera module includes providing an imager circuit board and a lens holder. The lens holder includes a lens holding portion and an attaching portion, with the lens holding portion accommodating a lens. The attaching portion of the lens holder includes pins that, when the attaching portion is located at the imager circuit board, are received at least partially through apertures of the imager circuit board. With the pins received at least partially through the apertures, the lens holder is laterally adjusted relative to the imager circuit board and the pins are soldered at the imager circuit board so as to attach the lens holder at the imager circuit board to form an imager assembly. The imager assembly is attached at a camera housing, and a processing circuit board is accommodated at the camera housing and electrically connected to the imager circuit board.
US10946808B2	Display screen mounting assembly A vehicle instrument panel assembly includes a display screen positioned within a housing, wherein the housing includes first and second protrusions. The vehicle instrument panel assembly includes a cross-car beam and a first bracket coupled to the cross-car beam. A second bracket is coupled to the first bracket and the first and second protrusions.
US10946807B2	Universal mounting system for tablet-controlled stereo head unit A hardware system and method for mounting a tablet computing device in a vehicle dash. The invention makes use of an inventory of prior art mounting kits that are configured to mount standardized aftermarket stereo head units in a vehicle dash while smoothly blending the aftermarket head unit into the surrounding dash to create a finished appearance.
US10946805B2	Surfboard rack for vehicles A surfboard rack device has a center post, two bottom receiver rings, and two top retainer loops. The bottom receiver rings may also have flexible netting forming bottom baskets, into which one end of a surfboard is inserted. The other end of the surfboard rests in one of the top retainer loops and is secured by an elasticized strap that hooks to a strap ring on the top retainer loop or a pair of hinged rigid arcs which lock together. The device is mounted on a vehicle either by sliding a trailer hitch insert into the vehicle's trailer hitch receptacle, or by hooking the flat hooks of the rack support over the top and bottom of the vehicle's trunk lid.
US10946804B2	Specified clamp force inducing transmission for a bicycle fork mount A drive mechanism for a load carrier includes a slip mechanism connected to a drive shaft and a retaining member configured to retain the slip mechanism. The slip mechanism includes a first member having a slot formed in a perimeter of the first member. The slot is configured to provide for easier rotation of the first member together with the retaining member.
US10946791B2	Out-of-vehicle notification device An out-of-vehicle notification device includes a moving person detecting unit configured to detect a moving person who is to be notified of information by means of light based on a result of detection performed by an outside situation detecting unit, a plurality of light emitting units, a light emission control unit configured to cause the light emitting units to emit light, and an operating state detecting unit configured to detect operating states of blinkers of the host vehicle. When an operation of the blinker is detected, the light emission control unit forbids light emission of the light emitting unit that is provided within a predetermined area around the blinker in operation.
US10946789B2	Vehicle lamp-cleaning system A system includes at least one sensor; a plurality of lamps fixed relative to the sensor; at least one vehicle component attached to the lamps; and a computer communicatively coupled to the lamps, the at least one sensor, and the at least one vehicle component. The computer is programmed to sequentially activate the lamps, determine that an intensity for at least one of the lamps is below a respective intensity threshold based on data from the sensor during the sequential activations of the lamps, and actuate the at least one vehicle component in response to one of the intensities being below the respective intensity threshold.
US10946788B2	Control device for vehicle lamp A control device for a vehicle lamp including an ECU configured to: i) receive a sensor signal and derive a total angle; ii) retain an initial set value of the vehicle posture angle, the initial set value being acquired in an initialization process; iii) retain a reference value of the vehicle posture angle, adjust an optical axis angle of the vehicle lamp in response to a change amount of a total angle during a stop of the vehicle, and retain a sum of the change amount of the total angle and the reference value of the vehicle posture angle as a new reference value; iv) not adjust the optical axis angle in response to a change amount of a total angle during traveling of the vehicle; and v) perform a predetermined reset process when a reset signal is received.
US10946785B2	Edge-stowable tent for trailer system A tent stowable around edges of a flatbed trailer to leave the floor of the flatbed trailer open for cargo and motor toys. The edge-stowable tent is supported internally by three rotationally deployable squared-off U-shaped supports. To be stowed, the tent and tent supports rotate to align with the front top edge and front portions of side top edges of the flatbed trailer. To be deployed, the tent and tent supports rotate to bring the rear edge of the tent to the rear edge of the flatbed trailer. Opposite legs of U-shaped tent supports are coupled to respective mounting supports on each side of the trailer, and rotate about aligned right-angled flanges to erect the tent. Support bars, attached to the top surfaces of front and side trailer walls or frame, support fasteners for bottom edges of the tent. The tent is stowed and erected by various means.
US10946784B2	Method of loading materials into a tank A tank and a method of holding a load and discharging a load therefrom. The tank includes a body having a first wall that bounds and defines a first compartment for holding a load therein and a second wall spaced outwardly from at least a portion of the first wall; wherein a second compartment is defined between the first wall and the second wall. The tank assembly includes an air piping system that is selectively actuated to place the first compartment and the second compartment under substantially similar or substantially equal air pressure. In one example the air piping system pumps air into the first compartment and the second compartment. In another example the air piping system evacuates air from the first and second compartments.
US10946783B2	Transport trailer A transport trailer includes an elongated body having spaced vertical supports for vertical actuators, a lower deck extending along and supported by the elongated body, and an upper deck supported by the vertical actuators. The upper deck is movable along the vertical supports via the vertical actuators. The upper deck can be lowered to a position to be substantially superimposed on top of the lower deck by the vertical actuators.
US10946778B2	Seat cushion assembly with pocket A seat assembly is provided with a foam cushion and a fabric portion connected to a B-surface opposite a seat surface of the foam cushion. At least one pocket cavity is defined between the fabric portion and the foam cushion. A pneumatic support assembly is contained in the at least one pocket cavity.
US10946763B2	Charging of an electric vehicle fleet A method for controlling the charging of multiple electric vehicles operating in a geographic area may include inputting a tariff schedule into a control system. The tariff schedule may identify the cost of energy at different times in the geographic area. The method may also include receiving data from the multiple electric vehicles. The data may include at least the state of charge of the vehicle. The method may further include sending instructions to at least one vehicle of the multiple electric vehicles. The instructions may include directives on charging based at least on the tariff schedule and the received data.
US10946762B2	System, apparatus and methods of electricity generation to end-use for fast charging of electric vehicle A system for charging electric vehicles (EVs) includes at least one transportable battery-energy-storage DC systems (BESDCS), at least one renewable direct-current (DC) power supply station at a first location. The system also includes at least one DC charging station for charging of the at least one EV at a second location different from the first location. The system further includes at least one electric tanker transport comprising at least one electric truck vehicle configured to be coupled to the at least one BESDCS. The electric tanker transport is configured to transport the at least one BESDCS from the first location to the second location for charging of the at least one EV and transport the at least one BESDCS from the second location to the first location for charging the at least one BESDCS from renewable DC power supply station.
US10946758B2	Light electric vehicle parking and charging stations and smart charging systems for the vehicle batteries A universal charging system is disclosed. In one example embodiment, the universal charging system includes a charging adapter configured to be mounted on a light electric vehicle (LEV), a charging station, and a processor configured to control charging of the LEV. The charging adapter may have electrical contacts for docking with a charging station and a charging interface for supplying power from the charging station to a battery of the LEV. The charging station may have at least one docking unit for receiving the charging adapter of the LEV. The at least one docking unit may have further electrical contacts for connecting to the charging adapter of the LEV.
US10946754B2	Wireless power transmission device The power transmission device includes a power transmission coil configured to transmit power in a wireless manner to a power reception coil of a power reception device, a plurality of foreign object detection coils disposed along an upper surface of the power transmission coil, and a power supply ECU.
US10946752B2	Hybrid vehicle The number of opportunities where external charging of a vehicle parked in a residential parking space or a charging station in a predetermined period is available is counted as the number of opportunities, and the number of times of the external charging performed in the opportunities in the same predetermined period is counted as the number of times of charging. The number of times of charging is then divided by the number of opportunities to calculate and store a charging frequency. Since the charging frequency is a ratio of the number of times that the external charging was performed to the number of opportunities where the external charging is available in the predetermined period, the ratio is used as an index that can offer more accurate determination regarding an external charging utilization status. As a result, various processing to promote external charging are executed more properly.
US10946751B2	Power supply device for vehicle A power supply device for a vehicle includes first and second power supply systems, a switch, and first, second, and third mode controllers. The first power supply system includes: a first power supply including a first power storage and a first generator, and an electrical apparatus. The second power supply system includes a second power supply. When an SOC of the first power storage exceeds a lower limit, the first mode controller supplies electric power from the first power supply to the electrical apparatus. When the SOC decreases below the lower limit, the second mode controller supplies electric power from the second power supply to the electrical apparatus via the switch. When an abnormality is detected to have occurred in the switch during the second power supply mode, the third mode controller supplies the electric power from the first power supply to the electrical apparatus.
US10946749B2	Movable power coupling and a robot with movable power coupling An apparatus comprises a first induction section comprising a first core and a first coil on the first core. A second induction section comprises a second core and a second coil on the second core. The first core comprises rail extensions, where at least two of the rail extensions extend from opposite ends of the first core. The second core comprises shoe portions located at respective ones of the rail extensions, where a gap is provided between each of the rail extensions and respective ones of the shoe portion. The second induction section is configured to move relative to the first induction section in a path along the extensions. The first induction section is configured to induce current in the second induction section, including when the second core moves relative to the first core along the extensions, to provide a contactless induction coupling between the first induction section and the second induction section.
US10946748B2	High power-density, high back EMF permanent magnet machine and method of making same An electric drive system includes a permanent magnet machine having a rotor and a stator and a power converter electrically coupled to the permanent magnet machine and configured to convert a DC link voltage to an AC output voltage to drive the permanent magnet machine. The power converter includes a plurality of silicon carbide switching devices having a voltage rating that exceeds a peak line-to-line back electromotive force of the permanent magnet machine at a maximum speed of the permanent magnet machine.
US10946746B2	Vehicle power system including ultra-capacitor for mitigating transient current events A vehicle power system includes loads, a battery coupled to the loads, an ultra-capacitor coupled to the battery, and a bypass circuit. The loads, the ultra-capacitor, and the battery are electrically coupled in series. The bypass circuit monitors the ultra-capacitor and prevents the ultra-capacitor from over-discharging and reversing in polarity.
US10946744B2	Vehicular projection control device and head-up display device A device includes a vehicle information acquisition part configured to acquire vehicle information containing a vehicle speed, a visibility information acquisition part configured to acquire visibility information on a road for travelling, a virtual vehicle video generation part configured to generate a virtual vehicle video of a virtual vehicle, which is to be moving ahead of a host vehicle in the same direction as the host vehicle, and a projection control part configured to control projection of the virtual vehicle video by a projection unit, such that a virtual image of the virtual vehicle video generated by the virtual vehicle video generation part is visually recognized in front of the host vehicle.
US10946737B2	Fuel valve A first casing has an internal cylindrical region defined as a floating/sinking guiding region for a float valve. The wall that forms the cylindrical region includes ventilation windows. A second casing surrounds the first casing to form, about the periphery of the first casing, a ventilation passage that guides fuel vapor in a fuel tank to the ventilation windows through a region that surrounds the first casing. In addition, the second casing surrounds the first casing from a first connection hole side to form, about the periphery of the first casing, a first ventilation passage that guides the fuel vapor in the fuel tank to the ventilation windows through the region that surrounds the first casing, and a second ventilation passage that has a larger passage cross-sectional area than the first ventilation passage. These ventilation passages stabilize floating/sinking operation of the float.
US10946735B2	Belt assembly for vehicle having hook and swing attachment and associated method A belt assembly for an associated vehicle has a body that includes a substantially planar region dimensioned for abutting engagement with the vehicle. At least one seal lip extends outwardly from a first face of the body to engage an associated surface of a vehicle window. A first hook is provided on the body for receipt over a terminal tip of the vehicle structural assembly, and a second hook is dimensioned for at least partial receipt through an associated opening around the door window opening. The first hook is positioned over the terminal tip and then the second hook is rotated until the second hook elastically deforms outwardly and subsequently snap fits into an associated opening and the substantially planar region abuts along the associated structural assembly of the door to preclude movement of the belt assembly upwardly, cross-car, and fore-and-aft relative to the associated vehicle.
US10946731B2	Optimized middle rain channel A sunroof apparatus for an automotive vehicle includes: a fixed glass panel having a first outer rim, and a movable glass panel having a second outer rim. A portion of the first outer rim of the fixed glass panel in the forward direction of the vehicle is adjacent to the movable panel and includes a water channel. A majority of the water channel is formed underneath of the movable glass panel such that the movable glass panel covers a majority of an upper open portion of the water channel when the movable glass panel is in a closed position.
US10946730B2	Door for vehicle A door of a vehicle may include a first door module forming a door skeleton; and a second door module coupled with the first door module and forming a door window, wherein the second door module includes a relatively lightweight material as compared to the first door module; and a reinforcement member is along an edge portion forming the door window of the second door module, reducing weight and cost of the door for the vehicle.
US10946729B2	Apparatus for varying transparency of window glass using wireless power transfer An apparatus for varying the transparency of a window glass can include: a window glass having a film with variable transparency; a pair of electrodes connected to the film; a controller mounted on a vehicle door of a vehicle, the controller controlling a wireless transfer of power for adjusting the transparency of the film; and a wireless power receiver mounted on the window glass, the wireless power receiver wirelessly receiving the power from the controller. The wireless power receiver can apply the power wirelessly received from the controller to the pair of electrodes.
US10946726B2	Air conditioning system, vehicle, control device, and control method An air conditioning system includes: an air conditioner to regulate a state of air in a room; a sensor device including at least one detector to detect an amount of an odor-causing substance included in the air in the room; and a control device to control operation of the air conditioner. The control device includes: a first acquisition unit to acquire a detected value of each of the at least one detector at a first timing when a person is present in the room; a second acquisition unit to acquire a detected value of each of the at least one detector at a second timing later than the first timing; a difference calculator to calculate a difference between the detected value at the first timing and the detected value at the second timing; and an instruction unit to control operation of the air conditioner based on the difference.
US10946725B2	Refrigeration system and control device A refrigeration system includes a generator, a power generation engine, a refrigerator, an electric power converter, an output control unit, and a characteristic estimation unit that estimates a refrigerator characteristic of a refrigerator according to an outside air temperature and a temperature of a cooling target space. The refrigeration system includes an output calculation unit that calculates a drive output as a target drive output that optimizes an energy efficiency of the entire system based on the refrigerator characteristic estimated by the characteristic estimation unit, an engine characteristic of the power generation engine, and a generator characteristic of the generator. Further, the output control unit controls the drive output to approach the target drive output calculated by the output calculation unit.
US10946724B2	Apparatus and method of controlling compressor of air conditioning device of vehicle An apparatus for controlling a compressor includes: an operation information detector which detects operation information from various sensors according to an operation of a vehicle; a compressor which compresses a refrigerant for operating an air conditioner; and a controller which performs starting acceleration control of momentarily decreasing an operation rate of the compressor, which uses engine power in an acceleration situation of the vehicle, in which the controller stores a first map, in which a starting acceleration entry condition according to a driving pattern and a heat load of the vehicle is defined in a plurality of levels, sets a starting acceleration entry condition having a final level corresponding to the driving pattern according to a starting acceleration entry frequency of a driver for a predetermined unit time within a limited level range of the first map, and adjusts a starting acceleration control frequency of the compressor.
US10946723B2	Vehicle air conditioner A vehicle air conditioner which is capable of inhibiting liquid return to a compressor and generation of noise due to bumping in an accumulator. There are executed a heating mode to close a solenoid valve 17, open a solenoid valve 21, let a refrigerant radiate heat in a radiator 4, decompress the refrigerant through an outdoor expansion valve 6, let the refrigerant absorb heat in an outdoor heat exchanger 7, and send the refrigerant to an accumulator 12, and a dehumidifying and heating mode to open the solenoid valve 17, close the solenoid valve 21, decompress the refrigerant through an indoor expansion valve 8, let the refrigerant absorb heat in a heat absorber, and generate heat in an auxiliary heater 23. A valve position of the outdoor expansion valve 6 is reduced for a predetermined period of time before shifting from the heating mode to the dehumidifying and heating mode.
US10946703B2	Tow bar apparatus and method A tow bar includes a shank. The proximal end of the shank is shaped and sized to releasably connect to a hitch receiver. The tow bar includes a first pivot coupler and second pivot coupler. The first pivot coupler preferably includes a first clevis rotatably connected to the distal end of the shank and connects the distal end of the shank to the proximal end of a pivot bar. The second pivot coupler connects the distal end of the pivot bar to a yoke having a proximal bracket and a distal bracket. A pair of arms connects to the distal bracket. Each arm is connected at its proximal end to the distal bracket via one of two third pivot couplers. Each third pivot coupler allows its connected arm to pivot in a substantially horizontal plane. Each third pivot coupler preferably includes a heim joint located at the proximal end of each arm.
US10946701B2	Heavy-duty tire A heavy-duty tire includes a tire sidewall (K) provided on a surface (Ks) thereof with a belt-like shaped serration extending in a tire circumferential direction. The serration is formed of a plurality of radially extending ridges arranged adjacently in the tire circumferential direction.
US10946699B2	Tire for two-wheeled automotive vehicle In a tire 2 for a two-wheeled automotive vehicle, a carcass ply 24 is extended on and between one bead 8 and the other bead 8 along inner sides of a tread 4 and sidewalls 6, and includes a main portion 24a and turn-up portions 24b, which are formed by the carcass ply 24 being turned up around the beads 8 from an inner side toward an outer side in an axial direction. An outer end Pp of each turn-up portion 24b is positioned outward of a tread end Pe in a radial direction. A band 14 is positioned between a belt 12 and the tread 4, such that the band 14 covers the belt 12. An outer end P1 of an inner layer 28 layered over a carcass 10 and the outer end Pp of the turn-up portion 24b are positioned facing each other.
US10946696B2	Axle assembly including a wheel end and method of manufacture An axle housing assembly includes an axle housing that includes a center portion and a first arm portion that extends from the center portion. The axle housing assembly further includes a wheel end housing that includes a wheel end body that extends from the first arm portion and a spindle that extends from the wheel end body.
US10946694B2	Dual tyre rim Disclosed is a drive assembly for an in-wheel motor, which in-wheel motor has a rotor, the rotor having an axis of rotation, a peripheral outer surface and a transverse road side surface, wherein the drive assembly is provided with a assembly adapted for supporting two tyres and includes a circumferential first part and a circumferential second part, each part provided with a rim-section for carrying a respective one of the two tyres, wherein the first part and second part are adapted to be mounted on the rotor from and at the transverse road side surface of the rotor and are detachable from the rotor from the transverse road side surface, and wherein the second part is detachable from the rotor independent from the first part.
US10946691B2	Embosser including rollers Embodiments of the disclosure set forth an embosser for a die. The embosser includes a frame having two sides. The embosser includes a handle and a roller body. The roller body includes a first roller in contact with the die and a second roller. In response to the handle being moved toward the roller body to a first handle position, the first roller is moved toward a first edge of the die and the second roller is in contact with the die. In response to the handle being moved toward the roller body to a second handle position from the first handle position, the first roller and the second roller remain in contact with the die and further press the die.
US10946688B1	Rigid paged book with interleaved book binding A ridged paged book has an interleaved book binding that incorporates page binding couplers that extend from one page to the other along a binding side to enable each page to open and close. A cover binding coupler extends from the front and/or back cover to an adjacent page and may have a cover portion that is longer than a page portion. This longer cover portion may extend along the recess of the cover to provide stability of the cover binding. Pins extend through the covers and pages along a binding side and into the binding couplers to create a durable binding for the rigid paged book. A ridged paged book may have an interleaved book binding configured proximal to a top and/or bottom edge. A ridged paged book may be made out of metal including the covers and pages and the couplers and pins.
US10946684B2	Printed material, image recording method, and image recording apparatus A printed material of the present invention is a printed material including a recording medium, a color material layer, and a fine irregular layer functioning as an outermost layer in this order; the color material layer contains a pigment; the fine irregular layer contains spherical particles having a specific average particle diameter; the spherical particles are present in a thickness direction of the fine irregular layer; and the surface of the fine irregular layer has convex portions having an average height of 0.04 to 0.15 μm and an image definition C(2) is 50% or more.
US10946679B2	Electric apparatus and control method therefor An electric apparatus for controlling movement of a target object by performing first and second feedback controls, based on a detection signal obtained from detecting the movement of the target object, generates an operation quantity on the target object based on first and second operation quantities for the second feedback control if one of a predetermined target value and an estimated first state quantity of the target object is higher than a first threshold value, and generates the operation quantity on the target object using only the first operation quantity from among the first and the second operation quantities if one of the target value and the first state quantity of the target object is lower than the first threshold value.
US10946676B2	Base material processing apparatus and detection method A displacement amount calculation part in a base material processing apparatus calculates the degree of matching between an upstream data section and a downstream data section included in an upstream and a downstream detection results, which indicate time-varying changes in the positions of an edge of the base material in the width direction at an upstream and a downstream detection positions. This calculation uses the results of comparison between signals in a predetermined frequency band extracted from the upstream detection result and signals in the predetermined frequency band extracted from the downstream detection result. Accordingly, a downstream data section that is highly matched with the upstream data section can be identified with high accuracy, and the amount of displacement of the base material in the transport direction can be detected with high accuracy on the basis of an identification result.
US10946673B2	Surface drying device for sheet-like non-permeable base material, printing apparatus, and printing method Provided are a surface drying device for a sheet-like non-permeable base material with enhanced drying efficiency on a surface of a sheet-like non-permeable base material having a liquid adhering to a surface thereof, and a printing apparatus and a printing method using the surface drying device. The surface drying device for a sheet-like non-permeable base material includes: a loading port for loading a sheet-like non-permeable base material with a liquid adhering surface; an air nozzle configured to spray high-temperature air; an unloading port for unloading the sheet-like non-permeable base material; an air shield zone forming portion, which is formed between the loading port and the unloading port, and is configured to form a heat-insulating air shield so as to cover the liquid adhering surface of the sheet-like non-permeable base material; and a retained air exhaust portion configured to exhaust retained air retained on the liquid adhering surface of the sheet-like non-permeable base material to outside of the air shield zone forming portion through use of a Coanda effect, to thereby replace liquid adhering surface air on the liquid adhering surface of the sheet-like non-permeable base material.
US10946672B2	Printed heating element A heating element is provided with a conductive path pattern which can be printed in a mask-free manner (e.g., drop-on-demand) with existing printing technology. The printing step can be performed, for example, with a thermal inkjet printer, a piezoelectric inkjet printer, an aerosol jet printer, or an ultrasound printer. The ink solution can be formulated so that it establishes an electrically conductive path which is free of polymer binders.
US10946670B1	Compositions, apparatus, methods, and substrates for making images and text Embodiments of the present invention feature apparatus and methods for manufacturing a personalized identification document including one or more dyes and/or pigments embedded in the substrate.
US10946663B2	Inkjet printing apparatus An inkjet printing apparatus is provided capable of attaching and detaching of a print head with a mechanism that is easily operable and simple, while preventing an erroneous operation. For the purpose, it is configured so that the press/release for the print head is possible along with movement of the joint member. Further, when the joint member is connected, the connection of the joint member is performed after pressing the print head, and when the connection of the joint member is released, the pressure on the print head is released after releasing the connection of the joint member.
US10946662B2	Wiping assembly for liquid ejection head and ink jet printer A wiping assembly for a liquid ejection head includes a wiper including a first wiper surface facing in a first direction and a second wiper surface facing in a second direction, a wiper cleaner, a mover, and a controller. A protruding portion of the wiper cleaner includes a first cleaning surface facing in the second direction and a second cleaning surface facing in the first direction. The controller controls the mover to move at least one of the wiper and the wiper cleaner in at least one of the first and second directions from a state in which the wiper is located farther in the second direction than the protruding portion to bring the first wiper surface into contact with the first cleaning surface, and to move the at least one of the wiper and the wiper cleaner in at least one of the first and second directions from a state in which the wiper is located farther in the first direction than the protruding portion to bring the second wiper surface into contact with the second cleaning surface.
US10946657B2	Liquid ejection head A liquid ejection head, including: a first head unit; a second head unit shifted with respect to the first head unit in both of a first direction in which nozzles of the head units are arranged and a second direction orthogonal to the first direction and disposed so as to overlap the first head unit in the second direction; and a first wiring member having flexibility and drawn from the second head unit in the second direction toward the first head unit, wherein the first wiring member includes a large-width portion on which a drive circuit is mounted and a small-width portion having a width in the first direction smaller than a width of the large-width portion in the first direction, and wherein the small-width portion passes through a space existing next to the first head unit in the first direction and extends in the second direction.
US10946647B2	Liquid discharge apparatus and method for controlling liquid discharge A liquid discharge apparatus that includes a liquid discharge head including a nozzle discharging liquid onto a recording medium and a pressure generating unit generating pressure by a change in a drive waveform of the liquid, a drive waveform generating unit generating the drive waveform applied to the pressure generating unit, and a waveform selection unit selectively masking a part of the drive waveform and selecting a pulse of the drive waveform, wherein the drive waveform includes at least one discharge pulse and a micro-drive pulse for causing a change in meniscus so that the liquid is not discharged at a point where the liquid is not discharged on the recording medium, wherein the micro-drive pulse is disposed at a head of a discharge cycle of the drive waveform, and wherein the micro-drive pulse is disposed at an integer multiple of a natural vibration cycle Tc of the liquid chamber.
US10946646B2	Recording apparatus and control method therefor Heating is conducted sequentially by dividing a heating operation into first heating control and second heating control consuming higher electric power than that in the first heating control.
US10946645B2	Pause start-up routine of imaging device Examples disclosed herein relate to an imaging device. Examples include a method for increasing the temperature of the imaging device by determining an internal temperature of the imaging device; determining if a start-up routine is to be initiated; pausing the start-up routine if the internal temperature is below a threshold temperature; and energizing at least one of a fan or heating element of the imaging device when the internal temperature is below the threshold temperature.
US10946643B2	Liquid ejection device and method for driving liquid ejection device A liquid ejection head includes a nozzle face provided with a nozzle configured to eject a liquid, a cap member configured to contact the nozzle face at a position enclosing the nozzle and to be fitted so as to cover the nozzle, the cap member being formed with an atmosphere communication hole to place an inside of the cap member and a surrounding atmosphere in communication with each other, and a clog determination mechanism configured to determine whether or not the atmosphere communication hole is in an at least partially blocked state.
US10946640B2	Transfer apparatus, liquid ejection apparatus, reading apparatus, image forming apparatus, control method of the transfer apparatus A transfer apparatus includes a head unit (210C, 210K) to process an object (W) transferred in a transfer direction, a first support member disposed upstream in the transfer direction with respect to a process position to support the object, a second support member disposed downstream in the transfer direction of the process position to support the object, a surface detector between the first and second support members to detect first surface information of the object, an upstream surface detector disposed upstream in the transfer direction with respect to the surface detector to detect second surface information of the object, an edge detector disposed closer to the upstream surface detector than the surface detector in the transfer direction to detect an edge of the object, and a controller to move the head unit based on detection results of the surface detector and the upstream surface detector and a detection result of the edge detector.
US10946639B1	Container decorating machine having a plurality of independent print workstations A turret styled container decorator machine is disclosed having a rotatable turret and a number of circumferentially spaced container holding assemblies for holding a variety of pieces of media, such as a drink container, the surface of which is to be printed upon with an image. A plurality of workstations are positioned around the perimeter of the turret through which each media holder passes as the turret rotates. Each workstation includes an ink printing assembly and a curing assembly so that ink may be applied and cured as each piece of media is indexed into each workstation location. Each printing workstation may be removed and replaced with a different arrangement or configuration of ink heads to suit different types of media sizes and shapes, and the turret holds a plurality of media holding means assigned to a pie-shaped section of the turret adjustable to accommodate various types of media geometries.
US10946638B2	Hybrid transfer machine A hybrid transfer machine includes: a body including a first drum installation part, a second drum installation part, a first body, a second body, and a worktable; a first drive means configured to allow wound fabric to be unwound; a thermal transfer unit configured to be installed in the second body, and to press and heat the fabric and transfer paper; a piece-type roller arm configured to be installed in the second body, and to guide the transfer paper to the third drum installation part; a second drive means configured to allow the transfer paper to be wound; a third drive means configured to allow the fabric to be wound; and a conveyer configured to be installed in the body, and to transfer the fabric and the transfer paper to the third and fourth drum installation parts.
US10946637B2	Printing press, method and apparatus for correcting a printing position of a printing unit An apparatus, a printing press and method for correcting the printing position of a printing unit of a printing press that has at least one sensor unit, where the method includes the steps of detecting an actual position of at least one print mark via the sensor unit, where the print mark is printed onto a printing material via the printing unit, determining of a deviation of the detected actual position from a setpoint position, determining at least one difference value that characterizes the deviation, determining a buffer value from a number of basic values previously stored in a memory, determining a correction value by subtracting the buffer value from the difference value, storing the determined correction value in the memory as one of the basic values, and correcting the printing position based on the determined correction value.
US10946635B2	Three dimensional printing system adaptable to varying resin types A kit enables an efficient and contamination-free method of changing a resin used in a three dimensional printer from a first resin to a second resin. The three dimensional printer includes a print engine and a receptacle. The kit includes a conduit assembly and a resin container. The conduit assembly includes a fluid inlet configured to be affixed in the receptacle in an upward orientation, a pump head configured to be coupled to a motorized pump actuator in the receptacle, a first conduit coupling the fluid inlet to the pump head, a fluid outlet configured to supply resin to the print engine, and a second conduit coupling the pump head to the fluid outlet.
US10946633B2	Additive manufacturing method An additive manufacturing method of manufacturing a product by laminating metal includes: laminating the metal so as to form a half-finished product of the product and a support; and spraying dry ice pellets having a particle shape to the support, after the laminating.
US10946631B2	Thermoplastic composite laminate and articles manufactured therefrom Disclosed are thermoplastic composite laminates comprising in order of: (a) a top layer composed of at least one polycarbonate sheet; (b) a fabric layer composed of a fabric comprising aromatic polyamide fibers and an adhesion aid; and (c) a bottom layer composed of at least one polycarbonate sheet; wherein the adhesion aid comprises polycarbonate oligomers having a weight average molecular weight of about 6500 or less.Also disclosed are articles comprising or produced from the thermoplastic composite laminates.
US10946628B2	Resin molded article A resin molded article has a resin base layer formed of an ultraviolet curable resin. The resin base layer is provided on one end side with a cover layer made of a polymer membrane. Further, the resin base layer is provided on the other end side with recessed portions dented toward the cover layer. A decorative layer is formed at least at recessed portions. The decorative layer is visually recognizable through the resin base layer and the cover layer.
US10946627B2	Weatherable first surface over a tie layer over a pultruded substrate The invention relates to a multilayered pultruded structure having a weatherable cap layer over a pultruded substrate, adhered with an appropriate tie layer. The structure provides improved weatherability and surface quality for pultruded structures. The invention is especially useful to provide a weatherable pultruded polyurethane, with an acrylic or styrenic cap layer. The weatherable polyurethane (PU) pultrusion of the invention provides an increased modulus over polyester pultrusions, making the weatherable PU pultrusion useful in commercial applications, and applications requiring a higher transverse modulus.
US10946621B2	Multiple layer panels having reduced levels of edge defects A process for producing a multilayer glass laminate panel having two glass sheets with a poly(vinyl butyral) interlayer sandwiched therebetween, the process comprising the steps of: providing two glass sheets; providing a poly(vinyl butyral) interlayer, and inserting the interlayer between the two glass sheets to produce a laminate; removing air from the produced laminate; applying heat and pressure to the laminate for a hold time, wherein the laminate is free of bubbles at the edges of the laminate. The multilayer glass laminate panel has improved optical properties, and specifically reduced levels of edge defects, such as edge bubbles in the laminate.
US10946618B2	Process for making 7xxx series aluminum/fiber reinforced polypropylene hybrid part for automotive crash absorption application A method to prepare a composite laminate object containing an extrusion grade 7xxx Al substrate and a fiber-reinforced polypropylene layer adhesively laminated to the substrate; is provided. The process includes shaping and cutting an extruded 7xxx aluminum to a profile, assembling a layered arrangement of the 7xxx Al profile as substrate, an adhesive film and a fiber reinforced polypropylene preform, heating the layered arrangement to a temperature of 160-175° C. to melt the polypropylene and activate the adhesive film, applying pressure to at least a surface of the fiber reinforced polypropylene preform to mold the preform to the shape of the extruded 7xxxAl substrate and obtain a semi-finished laminate object, cooling the semi-finished laminate object to 90° C., optionally, cooling the semi-finished laminate object to room temperature for inventory storage; heat treating the semi-finished laminate object at 90° C. for 2 to 8 hours; and then heat treating the semi-finished laminate object at 130° C. to 150° C. for 8 to 16 hours; and cooling the heat treated object to obtain the composite laminate object.
US10946612B2	Integrated multilayer structure for use in sensing applications and method for manufacturing thereof An integrated multilayer structure for use in sensing applications and a method of manufacture are presented. The multilayer structure includes at least one molded or cast plastic layer and a film layer on both first and second sides of said plastic layer. The film layer on the first side of said plastic layer is provided with reactance sensing electronics. The sensing electronics includes at least one sensing element and an electrical connection for connecting the sensing element to an associated control circuitry. The film layer on the second side of the plastic layer has a sensing area superimposed with the sensing element of the sensing electronics. The electrical distance between the film layer on the second side of the plastic layer and the sensing element are locally reduced by a physical feature at the position of the sensing area of the film layer to improve the associated sensing sensitivity.
US10946604B2	System and method for tire retreading A plurality of embodiments of a method and apparatus for retreading individual tires using one or more electrical heating bands and a component or device to apply a force to the retread tire package comprising a new or used core and a new retread along with an adhesive. In particular, the force may be applied using one or more plates that are connected to actuators for pushing the plates into the retread package to apply the force during curing of the package.
US10946601B2	Method of forming non-pneumatic tire using support structure deformation A method of forming a non-pneumatic tire is provided that includes the steps of providing an outer shear band ring (56) and an intermediate section (14) that has a supporting structure (16). The intermediate section (14) is collapsed from an uncollapsed state to a collapsed state. The intermediate section in the collapsed state is inserted inside of the outer shear band ring such that the outer shear band ring is located outward from the intermediate section in a radial direction of the tire. Compression of the intermediate section (14) is released when the intermediate section (14) is inside of the outer shear band ring (56) so that the intermediate section returns to the uncollapsed state from the collapsed state. In one embodiment, the compressing step of the intermediate section (14) is performed by a compression device (68) that has a plurality of gripping members.
US10946599B2	Method relating to phase change composite bimorphs A method bilayer composite thin-film beam structure is described. The structure incorporates a bulk phase change material as small inclusions in one layer of a bimorph. The structure, also referred to as a “phase change composite bimorph” or “PCBM”, curls abruptly, and reversibly, at a phase transition temperature. Large curling and effective expansion coefficients are demonstrated. The PCBMs may be employed in various self-assembly mechanisms and actuators.
US10946596B2	Methods and precursors for manufacturing a perforated composite part Precursors, and methods for manufacturing perforated composite parts, an exemplary precursor including structural fibers embedded in a cured matrix material and interposed between two removable plies, where the precursor may also have a sacrificial fiber extending through the removable plies, the matrix material and between the structural fibers.
US10946595B2	Method for composite flow molding An apparatus for molding a part includes a plunger cavity, a plunger, and a mold cavity, wherein the plunger is oriented out-of-plane with respect to a major surface of the mold cavity, and first and second vents couples to respective first and second portions of the mold cavity. In a method, resin and fiber are forced into the mold cavity from a plunger cavity, and at least some of the fibers and resin are preferentially flowed to certain region in the mold cavity via the use of vents.
US10946591B2	Method and apparatus for making bag using ultrasonic sealing A method and apparatus for making bags or pouches is disclosed. An ultrasonic sealer may be used to form the seals. Sealing patterns may be used to provide a desired strength profile.
US10946590B2	Injection molded assembly and method of joining injection molded parts An assembly of joined injection molded parts and a method for joining injection molded parts is disclosed herein. The assembly includes, but is not limited to, a first injection molded part having a first bonding area. The first bonding area has a plurality of first fingers extending from a surface of the first bonding area. The assembly further includes a second injection molded part having a second bonding area. The second bonding area corresponds in shape to the first bonding area and has a plurality of second fingers that extend from a surface of the second bonding area. The assembly includes an adhesive tape arranged between the plurality of first fingers and the plurality of second fingers. The adhesive tape is configured to bond the first injection molded part to the second injection molded part.
US10946587B2	Three-dimensional modeling apparatus and method for controlling three-dimensional modeling apparatus A three-dimensional modeling apparatus includes a nozzle that ejects a molten material, which is a plasticized thermoplastic material, a plasticization section which includes a flat screw having a groove extending in a volute shape and a driving motor that rotates the flat screw, the plasticization section rotating the flat screw to thereby guide the molten material to the nozzle through the groove, and an ejection control mechanism that is disposed in a flow path between the flat screw and the nozzle, and controls an outflow of the molten material from the nozzle.
US10946582B2	Method for producing a three-dimensional shaped product A method for producing a three-dimensional shaped product based on dispersion of powder by a squeegee and irradiation of the powder layer with a laser beam or electron beam, including the steps of installing a suction device that suctions fumes generated from the powder layer, in a state surrounding the entire periphery of a shaping table, and selecting a suction reference position at the shortest distance from the irradiation reference position currently moved and worked in a prescribed time range.
US10946575B2	Device and method for calibrating a blown film A device and a method for calibrating a blown film are provided, said device comprising: a tubular region with at least one inner wall, through which region the blown film can be passed; a liquid reservoir, which can be used to provide a liquid and which is situated above the tubular region, the liquid being guidable between the inner wall and the blown film; and a suctioning device, situated below the tubular region, for suctioning off at least part of the liquid from the blown film. At least one liquid-permeable element is provided, said element surrounding at least parts of the periphery of the blown film. This device permits the distance of the liquid-permeable element from the main axis of the blown film to be altered.
US10946571B2	Mould clamp with mould height adjustment system and method for the actuation thereof The invention relates to a mould clamp for an injection moulding machine, comprising a device for automatically adapting to the mould height of injection moulds (13) of different heights (a). A clamping device supported on an adjustable supporting element (21) is provided for moving a movable mould carrier (11) in the clamping direction (s-s) towards and away from the stationary mould carrier (10). A distance (x) between the stationary mould carrier (10) and the adjustable supporting element (21) can be adjusted by moving the supporting element, by means of a mould height adjustment system (14). A locking device (16) detachably locks the supporting element (21) in the respective position thereof, by pretensioning locking elements. A dynamically actuatable mould height adjustment system is produced by the locking elements being selectively relieved or pre-tensioned by active actuating elements, the pretension being cancelled in order to release the mould height adjustment system (14).
US10946570B2	Injection molding method and injection molding machine This injection molding method uses an injection molding machine for two-material molding, which comprises a first mold part that is provided with a cavity and a second mold part that is provided with a cavity and is arranged in tandem with the first mold part. This injection molding method comprises: a first molding step wherein a material is injected into the cavity of the first mold part and the material in the cavity is compressed; and a second molding step wherein a material is injected into the cavity of the second mold part. A pressure, which is generated in the second mold part by injecting the material into the cavity in the second molding step, acts on the first mold part, and a compressive force is applied to the material in the cavity in the first molding step.
US10946569B2	Method for producing a foam body having an internal structure A method for producing a foam body (10) having an internal structure (100, 200, 300), comprising the steps: I) selecting an internal structure (100, 200, 300) to be formed in the foam body (10), the structure comprising a first polymer material; II) providing a foam body (10), the foam body (10) comprising a second polymer material which is different to the first polymer material; III) injecting, by means of an injection means (20), a predefined amount of a melt of the first polymer material or a predefined amount of a reaction mixture (30, 31, 32) which reacts to form the first polymer material at a predefined location inside the foam body (10), corresponding to a volume element of the internal structure (100, 200, 300); IV) repeating step III) for further predefined locations inside the foam body (10), corresponding to further volume elements of the internal structure (10), until the internal structure (10) is formed. The invention also relates to a foam body (10) which has an internal structure (100, 200, 300) and is obtainable by the method according to the invention.
US10946565B2	Molded pocket in transaction card construction Methods and apparatuses are provided for manufacturing a transaction card. The disclosed methods and apparatuses may be used to form a transaction card frame within a mold. The transaction card frame may include one or more recessed portions formed within a first surface of the transaction card frame. The one or more recessed portions may be configured for affixing one or more electronic components.
US10946562B2	Sandwich structure including a VIP and method for producing the same The present invention relates to a process for the production of composite elements comprising a first and a second outer layer, a vacuum insulation panel between the two outer layers, rigid polyurethane foam in contact with the first outer layer and the underside of the vacuum insulation panel, and also rigid polyurethane foam in contact with the second outer layer and the upper side of the vacuum insulation panel, comprising application of a reaction mixture (R1) for the production of a rigid polyurethane foam onto the first outer layer, bringing the lower side of a vacuum insulation panel into contact with the unhardened reaction mixture (R1), application of a reaction mixture (R2) for the production of a rigid polyurethane foam to the upper side of the vacuum insulation panel, bringing the second outer layer into contact with the layer of the unhardened reaction mixture (R2), and finally hardening of the two rigid polyurethane foam systems (R1) and (R2) to give the composite element. The present invention further relates to composite elements thus obtainable, and also to the use of a composite element of the invention or of a composite element obtainable by a process of the invention, as component for refrigeration equipment or as construction material.
US10946561B2	Apparatus and method for producing a biocompatible three-dimensional object A method for making a biocompatible three-dimensional heart valve includes delivering, using at least one delivery unit, a biocompatible fluid substance towards a mold having a mold surface to obtain a coating layer of predetermined thickness that coats the mold surface, where the biocompatible fluid substance includes a plurality of particles; handling the mold and the delivery unit to provide a relative movement with at least three degrees of freedom between the mold and the delivery unit, the mold coated with the biocompatible fluid substance that is delivered to obtain a three-dimensional heart valve having a surface corresponding to the mold surface; removing, using a suction and blowing device, from the mold any surplus particles of the biocompatible fluid substance dispensed to make uniform the predetermined thickness of the coating layer; and pressing a counter mold on the coating layer deposited on the mold after delivering the biocompatible fluid substance.
US10946559B2	Multilayer riblet applique and methods of producing the same Multilayer riblet applique and methods of producing the same are described herein. One disclosed example method includes applying a first high elongation polymer material to a web tool, where the web tool is to be provided from a first roll, and heating, via a first heating process, the first high elongation polymer material. The disclosed example method also includes applying a second high elongation polymer material to the first high elongation polymer material, and heating, via a second heating process, the second high elongation polymer material. The disclosed example method also includes applying, via a laminating roller, a support layer to the second high elongation polymer material.
US10946557B2	Release agent for vulcanized rubber molding A release agent for vulcanized rubber molding is provided which has excellent mold releasing properties and washability. This release agent for vulcanized rubber molding contains an alkylene oxide adduct (A) of an active hydrogen group-containing compound having four active hydrogen atoms in the molecule, wherein the aforementioned alkylene oxide adduct (A) of an active hydrogen group-containing compound has a number average molecular weight of 5000-30000, and contains 50-95 mass % of an oxyethylene group.
US10946555B2	Conformal cooling molds with lattice structures for injection molding Methods, systems, and apparatus, including medium-encoded computer program products, for designing and manufacturing conformal cooling molds with lattice structures include, in one aspect, a method including: obtaining temperature and pressure data for a 3D model of a conformal cooling mold from computer simulation of injection molding; replacing a volume of the 3D model with a lattice structure to reduce the mass of the mold; adjusting a number of lattice unit cells for the lattice structure in accordance with the temperature data to increase heat conduction from hotter areas of the mold; adjusting thickness(es) of beams forming the lattice structure in accordance with the pressure data to prevent structural failure of the mold; and providing an updated version of the 3D model of the conformal cooling mold that incorporates the lattice structure after adjustment of the number of lattice unit cells and the thickness(es) of beams forming the lattice structure.
US10946550B2	Method for producing a roof tile having a water barrier and roof tile having a water barrier shaped thereon A method for producing a roof tile having a water barrier, wherein the water barrier is shaped onto a roof tile blank, which is supplied onto a lower mould, of a shaping unit, with a shaped piece and a shaping stamp that can move in relation to same. The shaped piece is placed on an upper side of a top end of the roof tile blank, and the shaping stamp is pressed against the top end of the roof tile blank, such that material of the roof tile blank is pressed into a shaping mould of the shaped piece. The roof tile blank is also arranged below the shaping unit and the shaping unit is vertically lowered onto the roof tile blank. The invention also relates to a roof tile produced according to this method having a water barrier shaped thereon.
US10946549B2	Device for the uniform distribution of slurries The invention relates to a conveyor line (1) for the continuous production of drywall boards as well as a slurry distributing device (22) which is used in this conveyor line (1). The distributing device is used for the uniform and low-speed flow distribution of slurries (20).
US10946547B2	Electric striking device An electric striking device is provided, including a main body and a striking unit. The main body includes an interior space and an outlet opening; the striking unit is disposed in the interior space, the striking unit includes an electromagnetic device, a driving member, a steering mechanism and an impacting member, the electromagnetic device drives the driving member to move along a direction perpendicular to an open direction of the outlet opening and further drive the impacting member to move along the open direction of the outlet opening.
US10946546B2	Apparatus and method for automated blade change for tissue saw A blade storage array is detachably mountable with a tissue log cutting saw. The saw has a cutting arm with a tool holder receptacle adapted and configured to hold a circular saw blade for the saw. The array has a plurality of storage units. Each storage unit is adapted and configured to store a circular saw blade for the saw. Each storage unit has a tool holder receptacle adapted and configured to hold a circular saw blade. Each storage unit is adapted and configured to move perpendicularly to the saw blade center axis.
US10946545B2	Nonlinear line of weakness formed by a perforating apparatus A web includes a curvilinear line of weakness. The curvilinear line of weakness includes a plurality of perforations. Each of the plurality of perforations is separated by a bond area. Each of the plurality of perforations has a perforation length and each bond area has a non-perforation length.
US10946544B2	Multifunctional machine An oscillatory power tool that is capable of using various types of cutting tools is disclosed. The power tool includes an output shaft for mounting one of the cutting tools and driving the cutting tool in an oscillating rotary motion. An end of the output shaft has a driving section for engaging with a securing section of the cutting tool. The power tool further includes a fastener connected to the output shaft at the end and connectable to the securing section of the cutting tool for fastening the cutting tool to the end of the output shaft. The driving section has a fitting surface for contacting a surface of the securing section. Through a close fit between the friction surface and the surface of the securing section, the power tool can be connected with different types of cutting tools, which greatly improves the universality and convenience of the power tool.
US10946542B2	Scissor assembly The disclosed technology includes a scissor assembly and method for using the scissor assembly. In some implementations, the scissor assembly includes first handle and a second handle connecting to each other via a flexible connector loop, two blades located on a first interior surface of the first handle and a first interior surface of the second handle, wherein the two blades are configured to slide adjacent to one another when the two handles are pushed towards each other. The scissor assembly may also include a lock to connect the two handles, the lock including a guide post located on the first handle configured to slidably move in a guide slot located in the second handle, a mouth located between the two blades when the scissor assembly is in an open position, the mouth to receive a first object of a predetermined size.
US10946541B2	Root cutting tool A tool for cutting through roots in the soil includes an elongate bar formed of solid steel with an enlarged knob on a top end and a weighted cutting head on a bottom end. The cutting head is formed of solid tempered steel and is in the configuration of an axe head with a sharpened arcuate cutting edge on the lowermost distal end. A longitudinal axis of the bar extends through a center of the cutting edge. In a preferred embodiment, the entire tool is made as one piece forged steel.
US10946538B2	Coupling structure for a personal care device A personal care device like a shaving device (1) comprises a base structure (2) and a head structure (3). The head structure comprises a first coupling element (5) and at least a head support structure (4) configured to hold at least one treatment head (4′). The base structure comprises a second coupling element (6). The coupling elements can releasably be coupled to each other for coupling the head structure to the base structure. By rotating the coupled coupling elements with respect to each other in a first rotational direction about a central axis (9), a first inclined surface (15) of at least one of the first and second coupling elements cooperates with a first co-operating surface (26) of the other of the first and second coupling elements thereby driving the first and second coupling elements away from each other in an axial direction extending parallel to the central axis.
US10946531B2	Modular robotic systems Exemplary embodiments provide modular robotic systems that allow one or more operation parameters of a robotic actuator, or group of actuators, to be dynamically configured or reconfigured. The operation parameters may be, for example, the X, Y, and/or Z position of the actuator or group of actuators with respect to other actuators, the arrangement of the actuator(s) into an array or matrix, the rotation or pitch of an actuator, the distance between actuators, the grip strength or grip surface of an actuator, etc. Accordingly, the same robotic manipulator(s) may be used for multiple purposes in multiple different contexts, manipulators can be swapped out on-the-fly, and robotic systems may be dynamically reconfigured to perform new tasks.
US10946528B2	Autonomous companion mobile robot and system An autonomous companion mobile robot and system may complement the intelligence possessed by a user with machine learned intelligence to make a user's life more fulfilling. The robot and system includes a mobile robotic device and a mobile robotic docking station. Either or both of the mobile robotic device and the mobile robotic docking station may operate independently, as well as operating together as a team, as a system. The mobile robotic device may have an external form of a three-dimensional shape, a humanoid, a present or historical person, some fictional character, or some animal. The mobile robotic device and/or the mobile robotic docking station may each include a fog Internet of Things (IoT) gateway processor and a plurality of sensors and input/output devices. The autonomous companion mobile robot and system may collect data from and observe its users and offer suggestions, perform tasks, and present information to its users.
US10946526B2	Robot taping system and method of taping A robot taping system for applying a sticky tape onto of an object; the robot taping system comprising: a scanner to scan the object; a computer to generate a 3D model of the object from a scan of the object obtained by the scanner, the computer allowing a user to define a selected area and the computer generating a taping path for covering the selected area with the tape; a programmable robotic arm configured to move along a trajectory corresponding to the taping path; a taping tool attached to a free end of the robotic arm and comprising a tape holder rod to support a roll of the tape thereabout and from where the tape is dispensed; and a taping roller to contact a non-sticky side of the tape and to press the sticky side of a tape onto the selected area during movement of the robotic arm along the trajectory.
US10946524B2	Safety system for integrated human/robotic environments Systems and methods are provided for specifying safety rules for robotic devices. A computing device can determine information about any actors present within a predetermined area of an environment. The computing device can determine a safety classification for the predetermined area based on the information. The safety classification can include: a low safety classification if the information indicates zero actors are present within the predetermined area, a medium safety classification if the information indicates any actors are present within the predetermined area all are of a predetermined first type, and a high safety classification if the information indicates at least one actor present within the predetermined area is of a predetermined second type. After determining the safety classification for the predetermined area, the computing device can provide a safety rule for operating within the predetermined area to a robotic device operating in the environment.
US10946522B2	Digital method and automated robotic setup for producing variable-density and arbitrary shaped metallic meshes A mobile manufacturing device and a method for producing three-dimensional lattice or mesh structures, wherein the mobile manufacturing device is a mobile device adapted to move along a three-dimensional structure to be produced, in particular while performing both translation and rotation movements in three-dimensional space, and wherein the mobile manufacturing device includes a means for detection of its position relative to the dimensional structure to be produced, so that the mobile manufacturing device is able to produce the three-dimensional structure as an autonomous robot.
US10946521B2	Movement planning apparatus, moving robot, and movement planning program A movement planning apparatus includes: an acquiring unit configured to acquire an environmental map in which a no-entry area is indicated for each of turning angles that a moving robot may have; and a planning unit configured to search for a moving path that allows at least one search branch to be extended from a departure point to a destination point based on the environmental map without making a change in the turning angle become discontinuous and without passing the no-entry area, and determine the turning angle on the moving path to the destination point based on a predetermined condition.
US10946520B2	Mobile robot system and control method thereof A mobile robot system and a related control method sets a virtual wall as a specific area so that a mobile robot cannot approach within a cleaning area to restrict a traveling of the mobile robot, registers the virtual wall on a map when the virtual wall for restrict the approach of the mobile robot is set by a terminal, calculates a location of the virtual wall for the cleaning area to avoid the virtual wall, and restricts the approach of the mobile robot by matching the virtual wall to the cleaning area, controlling the mobile robot as if an actual physical obstacle exists by setting the virtual wall on the map through the terminal and matching to an actual cleaning area, and achieving an easy cleaning setting and effectively controlling the mobile robot as it can be plurally set at a desired location irrespective of the number.
US10946518B2	Spatiotemporal controller for controlling robot operation A robot may include a spatiotemporal controller for controlling the kinematics or movements of the robot via continuous and/or granular adjustments to the actuators that perform the physical operations of the robot. The spatiotemporal controller may continuously and/or granularly adjust the actuators to align completion or execution of different objectives or waypoints from a spatiotemporal plan within time intervals allotted for each objective by the spatiotemporal plan. The spatiotemporal controller may also continuously and/or granularly adjust the actuators to workaround unexpected conflicts that may arise during the execution of an objective and delays that result from a workaround while still completing the objective within the allotted time interval. By completing objectives within the allotted time intervals, the spatiotemporal controller may ensure that conflicts do not arise as the robots simultaneously operate in the site using some of the same shared resource.
US10946513B2	Robot and robot system A robot comprising a base, an arm provided on the base, an actuator configured to drive the arm, a connector to which at least a part of a first wire of another device is connected, and a second wire configured to connect the actuator and the connector, wherein the base includes a cover through which the first wire is inserted, the cover covering at least a part of a hole of the base, and the cover includes a cutout for detaching the cover from the base by, in a state in which a screw fastening the cover and the base is loosened, sliding in a direction crossing a direction in which the first wire is inserted through the cover.
US10946511B2	Technician's work chair A technician's work chair having a frame, an air cushion assembly, a seat assembly, and air hose and a pivoting hose support. The air cushion assembly is attached to the frame and supports the frame on an air cushion formed above a floor surface. The seat assembly has a cushion portion on the frame and a seatback portion with a mechanism that changes an angle of inclination of the seatback portion. A technician seated in the seat assembly can ergonomically operate tools and complete tasks with arms raised over the technician's head. The air hose having a first end connected to a compressed air source and a second end connected to the air cushion assembly. The pivoting hose support biases the air hose to move in a rearward direction relative to the technician's work chair.
US10946509B2	Hand-held power tool and control method A control method for a hand-held power tool includes measuring a temperature of an electric motor, opening a switchable clutch if the temperature exceeds a first threshold value, and energizing the electric motor when the clutch is open until the temperature falls below a second threshold value. In an embodiment, the electric motor is switched to a current-free mode, i.e., switched off, if the temperature falls below the second threshold value. The second threshold value is preferably less than the first threshold value.
US10946506B1	Driving machine There is provided a driving machine capable of reducing a load applied to a guide member in a direction of a center axis. The driving machine drives a fastener into a workpiece. The driving machine includes a movable piston, a driver blade operating together with the piston and applying driving force to the fastener, a cylinder guiding operation of the piston, a holder provided in a housing and supporting the cylinder, and a vibration damping rubber interposed between the holder and the housing and receiving a load applied to the holder in an operational direction of the piston.
US10946500B2	Methods for laser cutting a polycrystalline diamond structure Methods of laser cutting polycrystalline diamond tables and polycrystalline diamond compacts are disclosed. Laser cutting of the polycrystalline diamond table provides an alternative to electrical-discharge machining (“EDM”), grinding with a diamond wheel, or lapping with a diamond wheel. Grinding or lapping with a diamond wheel is relatively slow and expensive, as diamond is used to remove a diamond material. EDM cutting of the polycrystalline diamond table is sometimes impractical or even impossible, particularly when the cobalt or other infiltrant or catalyst concentration within the polycrystalline diamond table is very low (e.g., in the case of a leached polycrystalline diamond table). As such, laser cutting provides a valuable alternative machining method that may be employed in various processes such as laser scribing, laser ablation, and laser lapping.
US10946499B2	Bonded abrasive article and method of grinding An abrasive article configured to grind a workpiece having a fracture toughness of at least about 5.5 MPa·m0.5 may include a body comprising abrasive particles contained within a bond material comprising a metal, wherein the body comprises a ratio of VAG/VBM of at least about 1.3, wherein VAG is a volume percent of abrasive particles within a total volume of the body and VBM is a volume percent of bond material within the total volume of the body, and wherein the abrasive particles have an average particle size of at least about 1 micron and not greater than about 20 microns.
US10946498B2	Method and system for machining, and a robot system The present invention discloses a method and system for machining a work piece by a machining tool, and a robot system using the same. The method comprises: defining a customized contact point on the machining tool by setting a contact point height of the machining tool; moving the machining tool against the work piece to apply predefined machining feeds. Compared with the existing prior arts, the proposed method and system improves machining efficiency and accuracy. With the method and system according to the present disclosure, high machining efficiency could be achieved as well as collisions could be avoided.
US10946497B2	Processing tool, particularly a roll tool, and method of processing a cylindrical sliding surface Processing tool for processing a surface of a workpiece. The processing tool includes a tool body which defines a tool axis. At least one first roll element, which is borne by the tool body, is rotatable around a first roll element axis and has a first outer surface with a rough surface structure in at least one first working section configured for rolling contact with the workpiece surface. Further, at least one second roll element, which is borne by the tool body, is rotatable about a second roll element axis and has a second outer surface that, in at least one second working section configured for a rolling contact with the workpiece surface, has a distance (r2) to the tool axis, which is less than a distance (r1) of the at least one first working section to the tool axis.
US10946495B2	Low density polishing pad Low density polishing pads and methods of fabricating low density polishing pads are described. In an example, a polishing pad for polishing a substrate includes a polishing body having a density approximately in the range of 0.4-0.55 g/cc. The polishing body includes a thermoset polyurethane material and a plurality of closed cell pores dispersed in the thermoset polyurethane material. Each of the plurality of closed cell pores has a shell composed of an acrylic co-polymer.
US10946493B2	Methods and systems for polishing pad control A non-transitory computer-readable storage media having computer-executable instructions embodied thereon for operating a polishing assembly for polishing of silicon wafers is provided. When executed by at least one processor, the computer-executable instructions cause the processor to receive thermal data of a portion of a polishing pad from a temperature sensor and determine a removal profile of a silicon wafer based at least in part on the thermal data. The computer-executable instructions cause the processor to operate a polishing head assembly to position the silicon wafer in contact with the polishing pad and to selectively vary the removal profile of the silicon wafer based at least in part on the thermal data.
US10946490B2	Method for supplying cutting oil A method for supplying cutting oil which is able to attain the above object by adopting the following processes in a machine tool for cutting work pieces. a. setting of individual cutting times to each work piece and selection of cutting oil to be used, b. setting of a quantity of the cutting oil supplied per unit time to a cutting area where the cutting oil selected by the process a is used, c. supplying the cutting oil to a cutting-oil tank, with a state kept that the cutting oil remains in the cutting-oil tank, and d. supplying the cutting oil to the cutting area on cutting each of the work pieces by setting a quantity of the cutting oil as a quantity obtained by multiplying individual cutting times according to the process a with a cutting quantity per individual unit times according to the process b.
US10946487B2	Method for producing a turbomachine impeller A method for producing a turbomachine impeller, which has a radially inner hub body, a radially outer shroud body and blades extending between the hub body and the shroud body. The blades, the hub body and the shroud body are designed as an integral, monolithic assembly includes providing a blank; milling the blank to form a basic contour of the hub body, the shroud body, and the blades; performing build-up welding or additive manufacturing at least once on the main contour that is formed and subsequently performing milling at least once on portions that are formed by the build-up welding.
US10946482B2	Laser processing apparatus A laser beam oscillated by a laser oscillator is condensed by a condenser. The condenser includes: a concave lens; a convex lens disposed at a predetermined interval from the concave lens, and disposed at a position such that aberration of a condensing point in the atmosphere is zero; and an actuator that generates an aberration at the condensing point in the atmosphere by changing the distance of the convex lens with respect to the concave lens. The actuator generates the aberration in the atmosphere such that the aberration of the condensing point is zero within a workpiece.
US10946481B2	Laser processing device According to one embodiment, a laser processing device includes a light irradiation section, and an optical element. The optical element includes a first transparent member provided via a gap with a tip of the light irradiation section, and a second transparent member. The first transparent member includes a first surface opposed to the tip of the light irradiation section, and a second surface provided so as to be connected to the first surface. The second transparent member includes a flat surface and a convex surface, the flat surface being provided so as to be opposed to the second surface of the first transparent member, the light passed through the first transparent member passing through the convex surface. An optical axis of the laser beam passing through the first surface and an optical axis passing through the convex surface are different from each other.
US10946479B2	Laser spot welding of overlapping aluminum workpieces A method of laser welding a workpiece stack-up (10) that includes at least two overlapping aluminum workpieces comprises advancing a laser beam (24) relative to a plane of a top surface (20) of the workpiece stack-up (10) and along a beam travel pattern (74) that lies within an annular weld area (82) defined by an inner diameter boundary (86) and an outer diameter boundary (84) on the plane of the top surface (20). The beam travel pattern (74) of the laser beam (24) surrounds a center area encircled by the annular weld area (82) on the plane of the top surface (20) so as to force entrained porosity inwards into a region of the weld joint (72) beneath the center area on the plane of the top surface (20) of the workpiece stack-up (10).
US10946478B2	Welding method and welded structure Objects to be welded are joined together by laser welding to form adjacent nuggets. When a distance between central axes of the adjacent nuggets is p and a diameter of the adjacent nuggets in the objects to be welded is d, the adjacent nuggets are formed so as to satisfy an equation 1.0
US10946477B2	System and methods for generating laser markings on metallised substrates The present disclosure includes systems and method relating to laser marking, in particular an apparatus comprises a fiber laser operable to produce a laser beam, an optics assembly operable to focus and direct the laser beam onto a non-metalized layer side of a substrate, wherein the substrate comprises the non-metalized layer side comprising a nonmetalized material and a metalized layer side comprising a metalized material, the metalized layer side being opposite the non-metalized layer side; and electronics communicatively coupled with the fiber laser and the optics assembly, the electronics being operable to control the fiber laser and the optics assembly, based on one or more laser settings, to direct the laser beam through the non-metalized layer side to be absorbed by the metalized layer side, generate a laser marking on the metalized material, and avoid generating the laser marking on the non-metalized material.
US10946476B2	Heat treatment and stress relief for solid-state welded nickel alloys A joining method includes performing a first heat treatment step on a first superalloy workpiece and a second superalloy workpiece wherein at least one of the first and second superalloy workpieces include a gamma matrix phase and a gamma-prime precipitate phase. The first and second superalloy workpieces are joined using a solid state joining process, subjected to a post-weld stress relief operation and a final aging heat treatment.
US10946466B1	Welder apparatus and methods Welder apparatus are provided that can include an inductor, with the inductor including: a fill coil; and a layered winding about the fill coil. Processes of providing power to a welding wand are provided that include pulsing power from a power source to an inductor, and then providing constant power from the inductor to the welding wand.
US10946465B2	Carbide-based hardfacing One aspect of the disclosure provides an iron-based hardfacing layer which includes hard or wear resistant phases resulting at least in part from dissolution of silicon and/or boron carbide particles into a liquid iron-based metal during the fabrication process. In an embodiment, the hardfacing layer is formed by a fusion welding process in which carbide particles are added to the molten weld pool. In an example, the filler metal supplied to the welding process is a mild steel. In an embodiment, the hardness as measured at the surface of the hardfacing ranges from 40 to 65 HRC. In an example, the iron-based hardfacing layer also includes tungsten carbide particles.
US10946462B2	Portable band saw In a band saw that is provided with a tension adjustment mechanism in which tension for an band saw blade can be adjusted, first and second wheel support shafts are provided in paired first and second wheel support portions, respectively, such that the first support shaft is parallel to the second support shaft. The first wheel support portion is configured to be movable in a direction in which a straight line extends, the straight line being perpendicular to both the first and second wheel support shafts. A first support is provided at a first end of the first wheel support portion, and a second support is provided at a second end of the first wheel support portion. Furthermore, an intermediate support is provided between the first support and the second support. A first load and a second load are configured to be applied to the second support and the intermediate support, respectively, such that the first load and the second load are parallel to the wheel support shaft and the direction of the first load is opposite to that of the second load.
US10946460B2	Splitting apparatus and splitting method A splitting apparatus includes: a lower mold configured to allow placement of a plate material on the lower mold and arranged on a first side with respect to a split target line of the plate material; an upper blade configured to be raised or lowered with respect to the lower mold; and a support member arranged on a second side with respect to the split target line of the plate material. The splitting apparatus is configured that, in a case where the upper blade is lowered with respect to the lower mold in a state where the plate material is supported by the lower mold and the support member, a cut is formed on the split target line of the plate material by the upper blade, a crack is formed in conjunction with formation of the cut, and the plate material is split along the split target line.
US10946459B2	Magnetorheological support method for blisk processing A magnetorheological support method for blisk processing is disclosed. In the method, a fork structure and a soft film are used to wrap magnetorheological fluid. The magnetorheological fluid is used for flow filling under certain pressure. The bulged soft film can conduct shape matching on the surface of a blisk blade. The magnetorheological fluid can be cured through magnetic field excitation, thereby ensuring the flexible support for a weak rigid component. Electric permanent magnets are symmetrically arranged at both ends of the fork structure to construct a uniform magnetic field that can realize a global excitation of magnetorheological fluid, so that the magnetorheological fluid works in a shear mode to achieve damping force controlling by magnetic field. The solid-liquid conversion of the magnetorheological fluid is controlled by an electric permanent magnet field.
US10946456B2	Apparatus and method for cutting inner surface of hole A hole inner-surface cutting apparatus includes a working head composed of a rotatable body having a cutting tool and a main body, a rotation rod for rotating the rotatable body, and a stroke rod for stroking the working head. At least three positioning mechanisms for positioning the working head along a radial direction in the penetrating hole is provided on the main body. Each of the positioning mechanisms has three sliders arranged radially, guide rollers respectively disposed on distal ends of the sliders, a piston for pressing the sliders radially outward, and a fluid pressure chamber for actuating the piston. Further provided is a controller for controlling fluid pressures in the fluid pressure chambers of the positioning mechanisms independently from each other.
US10946453B2	Coated cutting tool A coated cutting tool comprising a substrate and a coating layer formed on a surface of the substrate, wherein: the coating layer comprises at least one α-type aluminum oxide layer; and, in the α-type aluminum oxide layer, a texture coefficient TC (0,0,12) of a (0,0,12) plane is from 4.0 or more to 8.4 or less, and a texture coefficient TC (1,2,11) of a (1,2,11) plane is from 0.5 or more to 3.0 or less.
US10946452B2	Cutting tool and a nozzle with internally extending grooves The present disclosure relates to a cutting tool for metal chip removing machining having at least one internal coolant channel for fluid having a flow direction. The at least one internal coolant channel having a length and including a plurality of grooves extending internally at least partially along the coolant channel.
US10946447B2	Systems and methods for fabricating objects including amorphous metal using techniques akin to additive manufacturing Systems and methods in accordance with embodiments of the invention fabricate objects including amorphous metals using techniques akin to additive manufacturing. In one embodiment, a method of fabricating an object that includes an amorphous metal includes: applying a first layer of molten metallic alloy to a surface; cooling the first layer of molten metallic alloy such that it solidifies and thereby forms a first layer including amorphous metal; subsequently applying at least one layer of molten metallic alloy onto a layer including amorphous metal; cooling each subsequently applied layer of molten metallic alloy such that it solidifies and thereby forms a layer including amorphous metal prior to the application of any adjacent layer of molten metallic alloy; where the aggregate of the solidified layers including amorphous metal forms a desired shape in the object to be fabricated; and removing at least the first layer including amorphous metal from the surface.
US10946446B2	Method and device for producing a three-dimensional object A method for producing a three-dimensional object by applying layers of a pulverulent construction material and by selectively solidifying said material by the action of energy comprises the steps: a layer of the pulverulent construction material is applied to a support or to a layer of the construction material that has been previously applied and at least selectively solidified; an energy beam from an energy source sweeps over points on the applied layer corresponding to a cross-section of the object to be produced in order to selectively solidify the pulverulent construction material; and a gas flow is guided in a main flow direction (RG) over the applied layer during the sweep of the energy beam. The main flow direction (RG) of the gas flow (G) and the sweep direction (RL) of the energy beam are adapted to one another at least in one region of the cross-section to be solidified.
US10946444B2	Method of heat-treating additively manufactured ferromagnetic components A method of heat-treating an additively-manufactured ferromagnetic component is presented and a related ferromagnetic component is presented. A saturation flux density of a heat-treated ferromagnetic component is greater than a saturation flux density of an as-formed ferromagnetic component. The heat-treated ferromagnetic component is further characterized by a plurality of grains such that at least 25% of the plurality of grains have a median grain size less than 10 microns and 25% of the plurality of grains have a median grain size greater than 25 microns.
US10946439B2	Plaster casting mold fabrication method for a complicated structure aluminum alloy casting with a large inner cavity and a thin wall The application provides a plaster casting mold fabrication method for a complicated structure aluminum alloy casting with a large inner cavity and a thin wall, in which, a wax pattern is cleaned with a mixture; closed blind cavity and large plane unbeneficial to plaster mold-filling of the wax pattern are used to exhaust air by using vent holes and waterproof-breathable membranes in cooperation with each other; under pressure difference, plaster powder and mixed aqueous solution are vertically splashed and mixed in a mixing tank to reduce dust discharge; asynchronous mixing and grouting can be realized by left and right mixing tanks in an upper tank of a vacuum tank. The present application can effectively remove the surface parting agent, increase the wettability of the plaster paste and the wax pattern surface, and improve the surface finish of the casting mold.
US10946437B2	Cast metal products with high grain circularity Systems and methods for making aluminum alloy products are described including those that decrease the tendency for hot tearing or shrinkage porosity to occur during casting by introducing forced convection during the casting process. The forced convection may result in formation of high circularity grains during the solidification process, thereby increasing the permeability of the liquid aluminum alloy and decreasing the tendency for hot tearing or shrinkage porosity to occur.
US10946436B2	Filling method and filling device for kneaded sand When pressing kneaded sand in a kneading sand tank into a mold by a pressing member, a pressing force applied to a kneaded sand layer in the kneading sand tank is monitored and a moving position of the pressing member is monitored from when the pressing member starts to move. A pressing start time at which the kneaded sand starts to flow into the mold is identified based on the pressing force applied to the kneaded sand layer in the kneading sand tank, and a pressing starting position of the pressing member at the pressing start time is identified. As a result, the pressing start time and the pressing starting position of the pressing member when the kneaded sand starts to flow into the mold are accurately identified, so the reliability of a filling evaluation of the kneaded sand into the mold is improved.
US10946433B2	Manufacturing apparatus for heat exchanger fins Conveying of a molded body for heat exchanger fins at a high speed to prevents deformation of the molded body for heat exchanger fins and the generation of noise. A molding apparatus forms a plurality of cutaway portions at different positions on each molded body of the product width. A rotational shaft is provided that extends in the width direction and has a plurality of rotating discs that have a plurality of tapered protrusions, which are capable of advancing into the cutaway portions, formed on an outer circumferential surface thereof provided on the rotational shaft for each molded body for heat exchanger fins of the product width. When the plurality of cutaway portions of the molded bodies for heat exchanger fins of the product width, on which the plurality of cutaway portions has different positions, are disposed directly above the rotational shaft, the protrusions advance into the cutaway portions.
US10946426B2	Forming a bend in a corrugation The invention concerns a forming device intended to form a bend in a corrugation, the forming device comprising: a bottom frame (4) having a planar mounting surface (6) intended to receive a sheet metal plate having a corrugation projecting relative to a planar portion of the sheet metal plate, a projecting counter-form (5) arranged on the mounting surface and intended to be accommodated in the corrugation, the projecting counter-form having a stationary portion (7) and a movable portion (8) that is hinged, relative to the stationary portion, about an axis perpendicular to the mounting surface, a top frame (34) arranged above the bottom frame, a press configured to lower the top frame towards the bottom frame, and a hollow upper die carried by the top frame between the top frame (34) and the bottom frame (4), the hollow upper die (36, 37) being arranged above the movable portion of the projecting counter-form.
US10946425B2	Method for the stepped rolling of a metal strip A method for the stepped rolling of a metal strip unwinds the metal strip by a feed reel device and winds-up the metal strip by a winding reel device. The metal strip is guided through a roller gap formed between two working rollers during the rolling process, and the roller gap is changed in a controlled manner during the rolling process, whereby a thickness of the metal strip is changed in steps in the longitudinal direction during the rolling process. Tension applied to the metal strip is controlled such that the rolling force applied to the metal strip by the working rollers is constant during the rolling process.
US10946424B2	Cold pilger rolling mill and method for producing a pipe A cold pilger rolling mill including a front mandrel thrust block that has a distance of at least 30 m from a feed chuck, measured with the feed clamping carriage at the rear reversal point thereof. The distance is measured between the rear (in the feed direction of the hollow) end of the chuck of the front mandrel thrust block and the front (in the feed direction of the hollow) end of the feed chuck of the feed clamping carriage at the rear reversal point thereof.
US10946423B2	Particulate classification vessel having gas distributor valve for recovering contaminants from bed material A multi-stage product gas generation system converts a carbonaceous material, such as municipal solid waste, into a product gas which may subsequently be converted into a liquid fuel or other material. One or more reactors containing bed material may be used to conduct reactions to effect the conversions. Unreacted inert feedstock contaminants present in the carbonaceous material may be separated from bed material using a portion of the product gas. A heat transfer medium collecting heat from a reaction in one stage may be applied as a reactant input in another, earlier stage.
US10946422B2	Small-footprint systems, components, and methods for sterilizing medical waste Many hospitals and medical facilities have a need to safely dispose of their biomedical waste. Onsite processing, particularly with ozone, is often less expensive and safer than off site handling, but many facilities lack the room for conventional ozone equipment with appropriate capacity to meet their needs. Accordingly, the present inventors devised, among other things, an exemplary system that includes, among other features, an shredder, an upwardly inclined auger chamber, and a waste receptacle. The shredder shreds unsterilized waste and feeds into the lower end of the inclined auger chamber. The chamber includes ozone injectors to treat waste as the auger conveys it upward toward an outlet that drops the sterilized waste into the waste receptacle. The incline of the chamber allows for a smaller system footprint with sufficient processing capacity to satisfy the needs of smaller hospitals and clinics.
US10946419B2	Foreign substance removal apparatus and foreign substance detection apparatus An apparatus for removing at least one foreign substance includes a detection unit detecting the at least one foreign substance adhered to a holding surface of a suction holding unit configured to suck and hold a substrate, a removal unit removing the at least one foreign substance adhered to the holding surface using fluid, and a movement mechanism configured to move the detection unit and the removal unit.
US10946417B2	Systems and methods for high throughput sorting A high throughput sorting device is disclosed. The device includes a first sorter and a second sorter, each of the first and second sorters having a plurality of cells each configured to support, carry, and deposit an item. The device can also include at least one shared chute extending below a portion of the first sorter and a portion of the second sorter. The at least one chute can be configured to receive an item deposited by each of the plurality of cells and transport the item to an endpoint. The device can also include a base configured to support the at least one shared chute and the first and second sorters.
US10946416B2	Separation device with a conveyor feeding system A separation device has a conveying channel configuration and a transport belt configuration. A conveying material can be conveyed via the conveying channel configuration on the transport belt configuration, the conveying channel configuration has differently inclined regions, and a speed cascade of the conveyed material stream can be achieved by the differently inclined regions. The separation of the conveyed material stream is improved in that the conveying channel configuration has at least one wedge groove.
US10946407B2	Apparatus and method for atomization of fluid Various apparatus and methods for the atomization of fluid are disclosed herein. In one aspect, an apparatus for atomization of fluid includes a piezoelectric transformer comprising an electrode which is in communication a source of alternating current (AC) voltage at a proximate end of the piezoelectric transformer. A wick which is capable of absorbing a liquid is in contact with the piezoelectric transformer at the distal end, and the piezoelectric transformer is capable of inducing an electrospray of the liquid at the distal end.
US10946406B2	Metering apparatus The invention relates to an apparatus for metering a medium comprising a base element provided for fastening to a robot, a metering valve movably supported at the base element, and at least one piezo actuator by which the metering valve is movable relative to the base element.
US10946405B2	Turf system for sprinklers There is provided a turf cup assembly that attaches to a buried pop-up type sprinkler to blend a top of sprinkler both cosmetically and functionally with turf surrounding the sprinkler. The turf cup assembly includes a turf cup and a sleeve. The turf cup mounts to a riser of the pop-up type sprinkler. The turf cup contains soil and root structure of turf. The sleeve surrounds the turf cup and attaches to a top of a housing of a pop-up sprinkler. The sleeve can be at or slightly below grade, and the cup extends out of the sleeve during an irrigation cycle and retracts into the sleeve at the end of the irrigation cycle.
US10946404B2	Cleaning-filling station for means for spraying a coating product A cleaning and/or filling station (10) of a subassembly for spraying a coating product mounted on a moving arm of a robot having a receiving zone (Z120) for receiving at least one sprayer belonging to the spraying subassembly and a connection device between at least one feed circuit and the sprayer in place in the receiving zone. The connection device has at least one part (131) movable between a retracted position, at a distance from the sprayer, and an active position, where the connection device enables the sprayer to be fed with cleaning product and/or coating product. The station has a flexible membrane (150) firmly attached, on the one hand, to the moveable part (131) and, on the other hand, to a fixed envelope (112) for protecting a portion of the connection device, while this membrane is deformable and suitable for following the displacements of the moveable part (131) between the retracted and active positions thereof.
US10946401B2	Liquid dispenser with a discharge head A discharge head for discharging liquid as an atomized spray jet and as a non-atomized liquid stream or as individual droplets. The discharge head fastening fastens to a base unit and has a liquid outlet through which liquid is discharged from a reservoir into the atmosphere, and a liquid inlet through which liquid is conducted out of the reservoir to the liquid outlet. An internal part is arranged inside an outlet channel, and a spray opening is provided on the internal part. The internal part and the outlet channel are relatively displaceable so that in a first position a bypass duct is produced between an internal wall of the outlet channel and an outer face of the internal part, the flow resistance thereof being lower than the spray duct, and in a second position is partially closed wherein the flow resistance of the bypass duct is greater than the spray duct.
US10946400B2	Dispensing device for fluid products A dispensing device for fluid products includes a draw-up pipe, a main body and a dispensing head. The main body includes a pumping system, connected to the draw-up pipe and a fastening ring nut, for fixing the dispensing device to a container for fluid products. The fastening ring nut and the pumping system are mutually coupled for forming between them an air compensation duct which allows the selective passage of air from the outside towards the inside of the container during the operation of the dispensing device. The dispensing head in turn includes a cup, which has in a relative lower portion a passage, and a valve, housed in the lower portion of the cup, configured to adopt a first configuration, or open configuration, wherein the passage is put in fluid communication with the pumping system and a second configuration, or closed configuration, wherein the passage is occluded.
US10946399B2	Liquid reservoirs and articles comprising a repellent surface comprising a siloxane material Presently describes are articles, such as liquid reservoirs, comprising a liquid repellent surface. The liquid repellent surface comprises a surface layer comprising a silane or siloxane material, wherein the liquid repellent surface is not a lubricant impregnated surface. In one embodiment, the liquid repellent surface (e.g. layer) comprise a silicone melt additive and a thermoplastic polymeric material component. In some embodiments, the article (e.g. liquid reservoir) comprise a thermoplastic polymeric material.
US10946397B1	Apparatus and method for dispersing a chemical agent An apparatus includes an intake assembly, the intake assembly including a connector, the connector configured for coupling to a pressurized liquid source. The apparatus also includes a chemical storage assembly. The chemical storage assembly is coupled to at least one outlet of the intake assembly. The chemical storage assembly is configured for at least one of (a) storing a chemical or (b) mixing a chemical with a liquid from the pressurized liquid source. The apparatus further includes an outlet assembly. The outlet assembly includes a first outlet configured for expelling pressurized liquid from the pressurized liquid source in a first direction. The outlet assembly also includes a second outlet or a nozzle for expelling the chemical, the chemical mixed with the liquid, a chemical agent, or a foam mixture in a second direction.
US10946394B2	Shower head water-saving switching structure and shower head A shower head water-saving switching structure and a shower head are disclosed. The shower head water-saving switching structure includes a water inlet seat, a water discharging body, a functional water switching member, a flow switching member, and a drive mechanism. The water inlet seat and the water discharging body are connected to form a water distribution chamber therebetween. The drive mechanism includes a ratchet wheel, a push rod in linked with the ratchet wheel, and a button linked with the push rod. The functional water switching member and the flow switching member are rotatably accommodated in the water distribution chamber and linked with the ratchet wheel. The structure is simple, and the operation is effortless.
US10946393B2	Multi-nozzle multi-container fluid spray device The multi-nozzle multi-container fluid spray device includes multiple, for example, three, containers. Each container may hold a different liquid which the user may dispense individually. The containers are connected to each other and to a spray handle and spray head in a reversible manner. Multiple pumps and tubes may be housed within the spray head and one of multiple hoses may extend from each pump into one of the containers. Each pump is designed to dispense a liquid from one of the containers through a single nozzle end. Thus, a single spray bottle may individually dispense different solutions without mixing the solutions.
US10946389B2	Activation device with magnets An activation device for transmitting a user input to a control device has an engaging element that forms a first housing part and a feeding element that forms a second housing part. The engaging element has a push magnet, whose magnetic field extends into the feeding element and the feeding element has a push magnet that can be displaced without contact through exposure to the magnetic field. The engaging push magnet can be displaced in the direction of the feeding element by pressure-activating the activation device, and is set up to exert a magnetic force on a corresponding feeding push magnet. The engaging element and feeding element each have at least one rotating magnet that can be displaced parallel to an intermediate plane running between them. The engaging rotating magnet of the engaging element exerts a magnetic force on a corresponding feeding rotating magnet of the feeding element.
US10946388B2	Wear gauges and methods to electrically monitor the wear extent of a wear surface A wear gauge 10 comprises an elongate substrate 12 having a proximal end 14 and a distal end 16. At least a first row 18 of spaced electronic components 22.1, 22.3 . . . 22.n and a juxtaposed second row 20 of spaced electronic components 22.2, 22.4 . . . 22.n−1 are provided on the substrate. The first and second rows extend in a direction from the proximal end towards the distal end of the substrate. The electronic components 22.2 to 22.n−1 in the second row are spatially interposed between adjacent electronic components 22.1 to 22.n in the first row. The electronic components of the first and second rows are electrically connected in parallel by conductive tracks 19. An electrical parameter relating to the parallel connection as measured at a port 24 of the parallel connection towards the proximal end, changes as electronic components are removed from the connection from the distal end, to provide an indication of the extent of wear, as indicated by the arrow A.
US10946386B2	Roller mill and method for controlling a roller mill The subject matter of the invention is a roller mill comprising two rollers which are arranged in parallel, are pressed one against the other and rotate in opposite directions, wherein one of the rollers can be displaced orthogonally with respect to the axial direction of this roller, and two drives, which drives are each assigned to one of the two rollers, and each have an electric motor, a master of the electric motors predefines for the electric motors a setpoint value for the rotational speed of the torque as a reference, and a reference of a follower electric motor of the electric motors comprises the actual value of the torque or of the rotational speed of the master electric motor multiplied by a load distribution factor.
US10946385B2	Roller mill, aspirating assembly, and method for retrofitting a roller mill A roller mill (10) for grinding material, an aspirating assembly (23; 23′) and a method of retrofitting an existing roller mill. The roller mill (10) contains a grinding space (11, 11′) for grinding material, a separating wall (17) separates the grinding space from an aspiration space (21, 21′). At least one aspiration opening (13), is formed in the separating wall (17) through which aspiration air can flow due to a pressure difference between the aspiration space and the grinding space. The roller mill (10) has a closing element (14) for opening and closing the aspiration opening (13). The closing element (14) is in or moves into an opening position (O), which opens the aspiration opening (13), when the pressure difference exceeds a threshold value, and is in or moves into a closing position (S), which closes the aspiration opening (13), when the pressure difference falls bellow the threshold value.
US10946383B2	Oligonucleotide encoded chemical libraries This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.
US10946381B2	Microfluidic hydrodynamic shuttling chip device for highthroughput multiple single cells capture A hydrodynamic shuttling chip device comprising an array of single-cell trapping units is disclosed. Each unit comprises: (a) an incoming channel with a cell capture site; (b) a cell culture chamber located posterior to the cell capture site, having a receiving site spaced apart from the cell capture site at a distance of g; (c) a trapping channel located between the cell capture site and the receiving site; (d) a chamber channel located posterior to and in fluidic connection with the cell culture chamber; and (e) a by-pass channel, located lateral to the incoming channel, chamber and chamber channel and having a first end and a second end opposite to the first end, the first end branching out from the incoming channel immediately prior to the cell capture site and the second end joining the chamber channel. A method of capturing single cells of more than one type is also disclosed.
US10946380B2	Microfluidic chips for particle purification and fractionation Microfluid chips that comprise one or more microscale and/or mesoscale condenser arrays, which can facilitate particle purification and/or fractionation, are described herein. In one embodiment, an apparatus can comprise a layer of a microfluidic chip. The layer can comprise an inlet that can receive fluid, an outlet that can output a purified version of the fluid, and a condenser array coupled between and in fluid communication with the inlet and the outlet. The condenser array can comprise a plurality of pillars arranged in a plurality of columns. Also, a pillar gap sized to facilitate a throughput rate of the fluid of greater than or equal to about 1.0 nanoliter per hour can be located between a first pillar of the plurality of pillars in a first column of the plurality of columns and a second pillar of the plurality of pillars in the first column.
US10946378B2	Passive pumps for microfluidic devices Provided herein are passive microfluidic pumps. The pumps can comprise a fluid inlet, an absorbent region, a resistive region fluidly connecting the fluid inlet and the absorbent region, and an evaporation barrier enclosing the resistive region, the absorbent region, or a combination thereof. The resistive region can comprise a first porous medium, and a fluidly non-conducting boundary defining a path for fluid flow through the first porous medium from the fluid inlet to the absorbent region. The absorbent region can comprise a fluidly non-conducting boundary defining a volume of a second porous medium sized to absorb a predetermined volume of fluid imbibed from the resistive region. The resistive region and the absorbent region can be configured to establish a capillary-driven fluid front advancing from the fluid inlet through the resistive region to the absorbent region when the fluid inlet is contacted with fluid.
US10946376B2	Carrier element for introducing a dry substance into a flow cell A carrier element for introducing a dry substance into a cavity of a microfluidic flow cell or a chamber or cavities for interacting with a fluid, including: a plug-like body figure to be insertable into a passage of the flow cell leading to the cavity; and, a carder surface for receiving the drive substance, the carder surface being at an end of the body facing the cavity when the body is inserted in the passage.
US10946375B2	Disposable bioassay cartridge and method of performing multiple assay steps and fluid transfer within the cartridge The present disclosure provides a cartridge and method to move fluids within the cartridge that simplifies the design and removes the need for any internal valves or metering devices. The design is amenable to injection molded manufacturing lowering cost for large volume manufacturing. The design can be adapted to carry out both sample preparation and detection of biological substances including nucleic acids and proteins.
US10946374B2	Ergonomic pipette tips Provided herein are pipette tips having a proximal region with grooves and panels configured to facilitate wall expansion or wall compression when a pipette tip is mounted onto and sealingly engages with an appropriately designed liquid dispensing device.
US10946368B2	Catalyst and related methods involving hydrosilylation and dehydrogenative silylation A catalyst having a specific structure and a method of preparing the catalyst is disclosed. A composition is also disclosed, which comprises: (A) an unsaturated compound including at least one aliphatically unsaturated group per molecule, subject to at least one of the following two provisos: (1) the (A) unsaturated compound also includes at least one silicon-bonded hydrogen atom per molecule; and/or (2) the composition further comprises (B) a silicon hydride compound including at least one silicon-bonded hydrogen atom per molecule. The composition further comprises (C) the catalyst. A method of preparing a hydrosilylation reaction product and a dehydrogenative silylation reaction product are also disclosed.
US10946365B2	Materials and methods for oxidative dehydrogenation of alkyl aromatic compounds involving lattice oxygen of transition metal oxides In one aspect, the disclosure relates to a process for dehydrogenating a first dehydrogenation reactant into its unsaturated counterparts. The disclosed process comprises introducing a dehydrogenation reactant to a metal oxide catalyst having dehydrogenation activity, and dehydrogenating the dehydrogenation reactant to provide its unsaturated counterpart and hydrogen; selectively combusting the hydrogen released during dehydrogenation using a lattice oxygen from the metal oxide catalyst, resulting in a reduced metal oxide catalyst and steam; re-oxidizing the reduced metal oxide catalyst by introducing a gaseous oxidant to the reduced metal oxide catalyst; and optionally re-using the re-oxidized metal oxide catalyst for catalytic conversion and combustion. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
US10946363B2	Graphene modified iron-based catalyst and preparation and application thereof for use in Fischer-Tropsch reaction The present disclosure disclosures a graphene modified iron-based catalyst and preparation and application thereof for use in Fischer-Tropsch reaction, belonging to the technical field of catalytic conversion of synthesis gas. The catalyst consists of, by mass percent, 0.01-30% of graphene, 0-20% of promoter and 60-99.99% of iron oxide powder. The preparation process of the catalyst is as follows: the graphene, the iron oxide powder and the promoter are sequentially placed in an aqueous solution for ultrasonic treatment and stirring, and then rotary evaporation, drying and calcining are conducted. The preparation method is simple. The catalyst shows excellent activity in the Fischer-Tropsch reaction, and maintains a high CO conversion rate of 90% or above for a long time at a very high reaction space velocity; meanwhile, the alkane content in a product is low, and an olefin-alkane ratio can reach 14, thus having an extremely high industrial application value.
US10946362B1	Perovskite oxides for thermochemical conversion of carbon dioxide Perovskite oxides and catalysts containing the perovskite oxides are provided for the thermochemical conversion of carbon dioxide to carbon monoxide. The perovskite oxides can exhibit large carbon monoxide production rates and/or low carbon monoxide production onset temperatures as compared to existing materials. Reactors are provided containing the perovskite oxides and catalysts, as well as methods of use thereof for the thermochemical conversion of carbon dioxide to carbon monoxide.
US10946357B2	Process for feeding a polymerisation catalyst The present invention is directed to a process for feeding a polymerisation catalyst into a polymerisation reactor (7), comprising the steps of: (i) maintaining a catalyst slurry comprising a diluent and a solid catalyst component in a catalyst feed vessel (4); (ii) continuously withdrawing a stream of the catalyst slurry from the catalyst feed vessel (4); and (iii) introducing the withdrawn portion of the catalyst slurry into the polymerisation reactor (7), wherein the catalyst slurry is transferred by using a valveless piston pump (5) from the catalyst feed vessel (4) into the polymerisation reactor (7); the diluent has a dynamic viscosity of from 0.01 to 20 mPas at the conditions within the catalyst feed vessel (4), and wherein the catalyst slurry is transferred along a substantially vertical path downwards from the catalyst feed vessel (4) to the reactor (7).
US10946354B2	Dynamic mixer dispense valve for two-component high-viscosity high-ratio compounds A dynamic mixer dispense valve and metering apparatus suitable for use in mixing and applying high viscosity, disparate viscosity, high ratio and/or relatively immiscible two part compounds that exhibit short cure times includes a housing supporting a pair of valve assemblies each coupled to respective sources of base and accelerator components. A pair of pneumatic valve actuator s control the operation of the valve assemblies to control the flow of components into a mixing chamber. Within the mixing chamber a mixer impeller is rotatably supported and coupled to a source of rotational power. An additional pneumatic valve actuator combination operates a further flow control to prevent undesired material loss following a shot cycle.
US10946352B2	Blender system A blender for blending ingredients from a container with a fluid includes a bottle including a chamber with an opening to receive the fluid and a shoulder about the opening. The blender further includes a lid configured to couple with the bottle that includes a container receiver. The container receiver is configured to receive the container containing the ingredients and position the container against the shoulder when the lid is coupled to the bottle, wherein the shoulder is configured to have a shape and size to receive and seat the container. The container receiver is further configured to apply pressure to the container while the shoulder holds the container stationary to discharge the ingredients from the container into the chamber.
US10946351B2	Paddle, plating apparatus equipped with the paddle, and plating method A paddle for agitating a plating solution by reciprocating parallel to a surface of a substrate is disclosed. The paddle includes a plurality of vertically-extending agitation rods. Each agitation rod includes: a planar portion perpendicular to a reciprocating direction of the paddle; two slope surfaces extending from side ends of the planar portion in directions closer to each other, the two slope surfaces being symmetric with respect to a center line of the agitation rod, the center line being perpendicular to the planar portion; and a tip portion connected with the two slope surfaces.
US10946349B2	Mixing element for a static mixer A mixing element for a static mixer for installation into a tubular mixer housing has a longitudinal axis along which a plurality of installation bodies are arranged behind one another. A first installation body has a first wall element which extends in the direction of the longitudinal axis and a first side wall and a second side wall which is arranged opposite the first side wall. A deflection element is arranged adjacent to the first wall element and has a deflection surface extending in the transverse direction to the wall element at both sides of the wall element. A first opening is provided in the deflection surface at the side which faces the first side wall of the first wall element.
US10946344B2	Formation of diamond membranes In a first aspect, the present disclosure relates to a method for forming a diamond membrane, comprising: providing a substrate having an amorphous dielectric layer thereon, the amorphous dielectric layer comprising an exposed surface, the exposed surface having an isoelectric point of less than 7, preferably at most 6; seeding diamond nanoparticles onto the exposed surface; growing a diamond layer from the seeded diamond nanoparticles; and removing a portion of the substrate from underneath the diamond layer, the removed portion extending at least up to the amorphous dielectric layer, thereby forming the diamond membrane over the removed portion.
US10946342B2	Dynamic coating of MF/UF membranes for fouling mitigation A membrane system including an anti-fouling layer and a method of applying an anti-fouling layer to a membrane surface are provided. In an embodiment, the surface is a microfiltration (MF) or an ultrafiltration (UF) membrane surface. The anti-fouling layer can include a stimuli responsive layer and a dynamic protective layer applied over the stimuli responsive layer that can be a coating on a surface of the membrane. The stimuli responsive polymer layer can act as an adhesive prior to coating with the dynamic protective layer to aid in adhering the dynamic protective layer to the membrane surface. The dynamic protective layer can be formed by suitable nanoparticles that can prevent adhesion of foulants directly to the membrane surface. The stimuli responsive layer can be responsive to physio-chemical stimuli to cause a release of the stimuli responsive layer and the dynamic protective layer including foulants from the membrane.
US10946339B2	Water treatment apparatus A water treatment apparatus is disclosed. The water treatment apparatus, according to one embodiment of the present invention, may comprise: a filter unit comprising a reverse osmosis filter for supplying purified water filtered from raw water, and residential water which could not be filtered from raw water; a storage unit connected to the filter unit and comprising a storage member in which purified water is stored, then discharged, and a housing within which the storage member is provided, and through which residential water inflows and outflows; and a flow path changing valve connected to the filter unit and the storage unit, and which allows residential water to outflow from the housing as purified water is stored in the storage member, or allows purified water to be discharged from the storage member as residential water inflows into the housing.
US10946336B2	Oxidation catalyst, catalyst support structure, method of producing oxidation catalyst, and method of producing catalyst support structure An oxidation catalyst includes cerium dioxide particles and a metal oxide. The cerium dioxide particles contain an ancillary component that is at least one of lanthanum, aluminum, and iron. The metal oxide contains iron and manganese and is held by the cerium dioxide particles.
US10946335B2	Catalytic oxidation of NOx/SOx in flue gases with atmospheric oxygen as the oxidation reagent A NOx and SOx oxidation with atmospheric oxygen to remove NOx and SOx from flue gases. The combined system for catalytic oxidation and wet-scrubbing of NOx and SOx from a flue gas and manufacturing fertilizers includes: an air separation unit for separating atmospheric oxygen from air and producing an air stream enriched with atmospheric oxygen, an adsorption and oxidation reactor containing an oxidation catalyst and carrying out the catalytic oxidation of NOx and SOx by said oxygen to yield nitric and sulphuric acids, a separator and reactor control unit for separation of products and liquids and controlling the reaction; and a vessel containing ammonia streaming said ammonia into the reactor or into the control unit to react with the nitric and sulphuric acids and to yield the fertilizers.
US10946333B2	Ammonia separation method and zeolite Provided is a method for separating ammonia gas using zeolite membrane having excellent separation stability at a high temperature capable of separating ammonia gas from a mixed gas composed of multiple components including ammonia gas, hydrogen gas, and nitrogen gas to the permeation side with high selectivity and high permeability. Also provided is a method for separating ammonia by selectively permeating ammonia gas from a mixed gas containing at least ammonia gas, hydrogen gas, and nitrogen gas using a zeolite membrane, wherein the ammonia gas concentration in the mixed gas is 1.0% by volume or more.
US10946332B2	Open channel diffusiophoretic water filtration device and method A water filtration device is provided including a pressurized gas chamber receiving a pressurized gas; an open flow chamber receiving a colloidal suspension including water and colloidal particles, the open flow chamber having an inlet and an outlet, the colloidal suspension flowing between the inlet and at least one outlet in a flow direction; and a gas permeable membrane separating the gas chamber and the flow chamber, the gas capable of permeating the membrane, the membrane being water impermeable, the gas permeating the membrane in a direction normal to the membrane so as to induce diffusiophoretic motion on at least some of the colloidal particles opposite to or in a direction normal to the membrane; the at least one outlet having a first outlet with water having a higher concentration of the colloidal particles than a second outlet. Other devices and methods are also provided.
US10946328B2	Central tyre inflation system and method A central tire inflation system (CTIS) for a vehicle includes a reservoir for supplying air to the vehicle tires, a pressure sensor for monitoring air pressure in the reservoir, a compressor for supplying compressed air along a first flow path to the reservoir, a compressor timer for monitoring the run-time of the compressor, a dryer disposed on the first flow path for drying air supplied by the compressor, a purging system for routing air through the dryer along a second flow path to purge liquid from the dryer, and a controller for controlling the flow of air in the CTIS. The controller is configured: to activate the compressor in response to a request for a compressor operation, after which operation the air in the reservoir is at a post-operation pressure; when the compressor operation is complete, to determine a compressor activation period, and to determine if the compressor activation period is greater than or equal to a target period; and if the compressor activation period is less than the target period, to keep the compressor activated until pressure in the reservoir increases to a base target pressure greater than the post-operation pressure; and if the compressor activation period is greater than or equal to the target period, to keep the compressor activated until pressure in the reservoir increases to an elevated target pressure higher than the base target pressure and to activate the purging system to route air from the reservoir to purge the dryer of liquid.
US10946320B2	Oil separating device An oil separating device for separating an oil mist from a blow-by gas is arranged on a flow passage of the blow-by gas. The oil separating device includes an oil separator having an inlet formed at one end thereof and an outlet formed at another end thereof opposite to the one end; a collision wall arranged at a downstream side of the oil separator, and including an uneven portion formed on a surface thereof to face the outlet of the oil separator; and a filter arranged between the oil separator and collision wall. The oil separator is formed such that the oil mist in the blow-by gas coalesces together to form a coalesced oil mist, the filter removes the coalesced oil mist from the blow-by gas, and the collision wall separates a remained oil mist remained in the blow-by gas through the filter.
US10946319B2	Filter assembly for improved filter cartridge placement and detection in a refrigerator appliance A filter assembly with features for improved filter cartridge placement and detection are provided. The filter assembly includes a filter cartridge and a filter housing for receiving the filter cartridge. A contact member extends from the filter housing for engaging the filter cartridge when the filter cartridge in the installed position. A first contact is mounted to the contact member and a second contact is mounted to the filter cartridge such that the first contact and the second contact establish an electrical connection when the filter cartridge in the installed position.
US10946317B2	Fuel filter having high resistance to icing A cartridge for a filtering device, includes a cylindrically arranged pleated cloth, the pleats being parallel to the generatrix of the cylinder, wherein the cylinder includes a non-pleated region which is to be placed across from a fuel inlet into the filtering device.
US10946314B2	Pressure control device A pressure control device is provided and includes a body which has a groove-shaped flow path including a groove part and a widened part connected to the groove part and having a width larger than a width of the groove part, and a filter unit which captures foreign matters mixed in a fluid which passes through the groove-shaped flow path. The filter unit includes a frame body being in a cylindrical shape and including a through hole part which penetrates in a direction along a central axis, and at least one filter member being in a planar plate shape disposed to intercept the through hole part and supported inside the frame body, in which the filter unit is accommodated in the widened part so that a direction orthogonal to the central axis of the frame body is along a depth direction of the widened part.
US10946311B1	Discovering context-specific serial health trajectories Systems and methods are provided for injury characterization including detecting matches of an individual subject's record (such as an athlete's record) with collections of other subjects records, based on serial, longitudinal patterns, for facilitating athlete health and training, preventive and rehabilitation medicine, and risk management in athletics. In an embodiment, time series are formed from information pertaining to successive longitudinal episodes of injury and the circumstances in which the injuries were incurred; calculating time-series K-nearest-neighbor clusters and distances for each such combination; determining the cluster to which a given candidate player injury record is nearest or belongs, and prescribing an injury-risk reduction intervention specific to the plurality of hazards that are characteristic of trajectories that are members of that cluster and that are deemed to be relevant to reducing or mitigating those hazards and thereby are efficacious in preventing subsequent injuries that are prevalent in that trajectory cluster.
US10946309B2	Liquid-liquid mass transfer process and apparatus A fiber bundle contactor may include a vessel including a first inlet; a second inlet; a mixing zone arranged in the vessel to receive a first fluid from the first inlet and a including fluid from the second inlet, wherein the mixing zone comprises a perforated plate assembly comprising a plate, a plurality of openings in the plate, and a plurality of riser pipes that extend from the plate and arranged to allow fluid flow through additional openings in the plate; and an extraction zone including a fiber bundle arranged in the vessel to receive the first fluid and the second fluid from the mixing zone.
US10946307B2	Extraction of cannabinoids, curcuminoids and ginsenosides An example method for extracting phytochemical oil from plant parts includes freezing plant parts from at least one of Cannabis sativa, Curcuma longa, Panax ginseng, and Panax quinquefolius. The frozen plant parts are reduced to a plant powder, which is suspended in an aqueous buffer. The aqueous buffer containing the suspended plant powder is incubated with at least one pectinase and at least one cellulase. An aqueous phase of the incubated aqueous buffer is evaporated through steam heating to obtain a steam dried product. Phytochemical oil, which includes at least one of cannabinoids, curcuminoids, and ginsenosides, is extracted from the steam dried product.
US10946305B2	Method for producing cocrystals by means of flash evaporation The invention relates to a method for producing a cocrystal of at least two compounds by means of instantaneous evaporation or flash evaporation, for example for the production of cocrystals in the fields of energetic materials, pharmaceutical compounds, phytopharmaceutical compounds, ferroelectric materials, non-linear response materials or bioelectronic materials.
US10946303B2	Short distillation head with bulbous lower collector The distillation apparatus of the disclosed technology has a bulbous bottom side which extends below a plane defined by an outer cover which circumscribes a rest of a lower collector region which has there-within the bulbous or spheriod end. Further within the outer cover and/or functionally connected to the lower collector region is a vertical tube passing both into an area circumscribed by the lower collector region as well as passing into an area circumscribed by a fraction collector situated there-above. The fraction collector can have a same width (horizontal directional extent) as the lower collector region at a widest portion thereof. A rejection area can be created beneath the spheroid bottom end of the lower collector region as well at an interior top side of the lower collector region outside of the vertical tube.
US10946294B1	Summarizing notifications on a user display Techniques for managing notifications are described. In an example, a computing device presents content in an application window based on an execution of an application. Notification data is received by a computing device. Based on a context associated with the computing device, such as whether the application window is the foreground and whether the notification data is associated with the application or such as the operational mode of the computing device, a determination is made whether to present a corresponding notification in-context within the application window or in a pop-up window. Otherwise, the notification is added to a notification list and can be summarized in a notification summary.
US10946293B2	Configuring headset voice morph based on player assignment Methods and systems are provided for adaptively modifying audio during online multiplayer games. In an audio system that outputs audio to a use, one or more audio control settings, for adjusting audio generated or handled in the system, may be determined based on a reference audio, with at least one of the one or more audio control settings being configured to adjust a voice associated with a user of the system. Audio handled in the system during the operation of the system by the user may then be processed, with the processing including applying the one or more audio control settings, and modifying, based on applying the one or more audio control settings, at least audio corresponding to a voice associated with the user. The reference audio may be processed, and the at least one audio control setting may be determined based on the processing of the reference audio.
US10946285B2	Program, terminal device, game system and game system control method for changing displayed game media based on processing request A program executes a step that displays one or more first game media in a first region on a screen, a receiving step that receives a request for a first processing that determines selected game media from among a plurality of game media including at least the first game media displayed in the first region, a step that displays the selected game media determined by the first processing, and a change step that changes at least a portion of the first game media out of the one or more first game media displayed in the first region to other first game media, each time the first processing is executed.
US10946284B2	Systems and methods for capture and use of local elements in gameplay A computer-implemented method is provided for enabling virtual gameplay. Access is provided to at least one video game in which a player is able to interact with the video game according to a storyline. A player location is detected and stored. A local element is retrieved from a database based on the player location and the local element is correlated to a local element script actuatable in the video game. This local element script is retrieved and actuated in the video game to supplement or replace the video game's storyline.
US10946281B2	Using playstyle patterns to generate virtual representations of game players In various embodiments of the present disclosure, playstyle patterns of players are learned and used to generate virtual representations (“bots”) of users. Systems and methods are disclosed that use game session data (e.g., metadata) from a plurality of game sessions of a game to learn playstyle patterns of users, based on user inputs of the user in view of variables presented within the game sessions. The game session data is applied to one or more machine learning models to learn playstyle patterns of the user for the game, and associated with a user profile of the user. Profile data representative of the user profile is then used to control or instantiate bots of the users, or of categories of users, according to the learned playstyle patterns.
US10946280B2	In-game reactions to interruptions The present disclosure describes methods and systems directed towards the generation of various in-game reactions based on different types of interruptions that may occur in the real-world. The present invention is able to monitor and detect when the various interruptions in the real-world occur. Based on the type and assigned importance of the interruption, a corresponding in-game reaction can be provided to the user to inform the user of the interruption. Depending on the importance of the real-world interruption, instructions can also be generated for the user device associated with the game. These instructions can allow the user to step away from the game without causing an interruption with other players playing within the same game.
US10946272B2	PC blaster game console A portable gaming device includes a game console housing including a handle, a trigger, a screen holder, and a display device coupled to the screen holder. The display device includes a display. The portable gaming device also comprises a processing circuit internally coupled to the game console housing including a processor, a memory, and a network interface, wherein the processing circuit is in communication with the display device. The processing circuit generates a user interface to be displayed on the display, determines a position of the game console housing, and updates the user interface based on the determined position of the game console housing.
US10946271B2	Controlling data processing A control apparatus includes two or more user control devices, each user control device having an inertial detector having a wireless communications module to communicate inertial detection results, and an illuminated portion; and a housing to house the two or more control devices so that the two or more control devices are constrained to move with one another but having an obscured portion so as to obscure all but one of the illuminated portions of the two or more control devices.
US10946264B2	Reduced contact length snowboards and splitboards Snowboards and splitboards having a contact length less than or equal to 65% of the length of the snowboard or a contact length equal to or less than half the length of the snowboard are disclosed. In some embodiments, a peak of a cambered section is aligned with a horizontal midline of the snowboard. In other embodiments, a peak of a cambered section is aft of a horizontal midline of the snowboard. Optional features of the snowboards and splitboards include bi-lobed tips, bi-lobed tails, touring tails and/or dual recurved tails.
US10946262B2	Golf training aid A golf training aid may appear to take the form of a golf club, sometimes without a club head. At a proximal end, or end near the golfer, the training aid may comprise a standard golf grip attached to a carbon fiber cylinder portion, the cylinder portion containing a magnet, with a rubber seat disposed upon the magnet. A metallic ball bearing may be in magnetic attachment the magnet. A plurality of additional ball bearings, smaller than the metallic ball bearing, may be magnetically retained and distal to metallic ball bearing. The ball bearings may be disposed within a laminated polycarbonate tube. A far end or distal end of the training aid may comprise a rubber plug to contain ball bearings that have traveled down the tube, optional weights and a magnetic end cap.
US10946261B2	Punching surface A padded punching surface incorporating elastic roping connected to a frame which allows the punching surface to be struck with a force of impact by a user so as to minimize swinging of the punching surface. The apparatus is an improvement on existing punching bags which enables easier convenient and more realistic combat training for athletes and users. The amount of swing for the punching surface can be adjusted by tightening or loosening the elastic roping. The punching surface can include an attached head shaped surface for more realism.
US10946256B2	Golf putter head and golf putter including same Provided is a golf putter head, which includes a head body; and a hitting member provided in front of the head body for hitting a golf ball, and to be freely slidable up and down within a predetermined range with respect to the head body. According to the present invention, when the golf putter hits the golf ball, as spin of the golf ball is smoother, directionality of the golf ball is increased.
US10946249B2	Swim paddle A swim paddle system includes a substantially planar, rigid paddle having a first side for receiving a hand of a swimmer and a second side opposing the first side with a plurality of through holes extending through the paddle from the first side to the second side, the first side having a palm region for receiving a palm of the hand and a peripheral region for receiving a thumb, an index finger, a middle finger, a ring finger, a little finger, and a wrist of the hand. At least a portion of the paddle is transparent or translucent to allow at least a portion of the hand to cast a shadow as light shines through the paddle.
US10946246B2	Interactive motion management device combined with human physiological information and sports information An interactive sports management device combined with human physiological information and sports information includes a user module, an exercise module and a management module, wherein the user module is used to detect the physiological information of the user, and transmit the user identifier and the physiological information to the exerciser module. The exercise module is used to collect the sports information of the sports fitness equipment, and transmit the user identifier, the physiological information, the exerciser identifier and the sports information to the management module. The management module transmits the management information to the exerciser module. In this way, the sports information generated when the specific person uses the specific sports fitness equipment for exercise is combined with the human physiological information into the personalized information.
US10946242B2	Swing analysis device, swing analysis method, and swing analysis system A swing analysis device includes: an acquisition unit (swing video acquisition unit) acquiring a swing video of a user; a processing unit deciding an impact timing and a tempo, based on the swing video; and a display unit displaying the swing video and the tempo. The display unit, while displaying the swing video, displays the tempo when the impact timing is reached in the swing video.
US10946237B2	Exercise bike An exercise bike includes a frame, a rotor assembly and a drive assembly mounted on the frame, where the drive assembly is configured to drive rotation of the rotor assembly, and a cover configured to at least partially cover the rotor assembly. The components of the drive assembly and the rotor assembly include structures that improve the performance of the exercise bike, including but not limited to a strong and rigid construction and improvements in belt tracking, user feel, effort consistency, synchronization, and rotor performance.
US10946235B2	Yoga mat with additional features An accessorized yoga mat includes at least a mat including at least two configurations, a rolled configuration, and an unrolled configuration; a closure mechanism that secures the mat in the rolled configuration; and a carrying strap removably engaged to the mat and capable of supporting the mat during transport.
US10946230B2	Exercise machine support system An exercise machine support system for providing increased versatility including inclination or declination of an exercise surface, a reduction in the overall length and width of the exercise machine, and an enhanced user interface which reduces the risk of injury. The exercise machine support system generally includes a cantilevered exercise machine which is adapted to have a variable angle of incline or decline with respect to a horizontal ground surface. The exercise machine will generally include a base and a support which extends between the base and the exercise machine. The upper end of the support is connected to the exercise machine by a first pivot such that the exercise machine pivots about the support. An adjustment device may be utilized to pivot the exercise machine and thus adjust its angle of incline. Various types of adjustment devices are disclosed, including an actuator, ratchet-and-pawl, gears, and cam.
US10946229B2	Exercising equipment combination An exercising equipment combination includes a plurality of exercising devices, and a connecting device connecting the exercising devices. Front ends of the exercising devices abut each other. Each of the exercising devices includes a support post and a secondary table mounted on the support post. The secondary tables of the exercising devices are juxtaposed and put together to form a primary table which has a predetermined geometric shape.
US10946224B2	Multi-stage nasal filter and method of tuning the filter to a predetermined most penetrating particle size Respiratory devices and methods for their manufacture and use are disclosed. The device features a resiliently deformable element configured to form a perimeter seal with the inner nostril wall and to swab the distal portion of the internal nostril region with a disinfectant during device installation. A first filter stage includes a first filter layer characterized by first geometric convolutions and a first MPPS1 value; and a second filter stage includes a second filter layer characterized by second geometric convolutions and a second MPPS2 value.
US10946217B2	Beam angle optimization for external beam radiation therapy using sectioning Methods of beam angle optimization for intensity modulated radiotherapy (IMRT) treatment include determining beam's eye view (BEV) regions and a BEV region connectivity manifold by evaluating dose response of each region of interest for each vertex in a delivery coordinate space (DCS). The information contained in the BEV regions and the BEV region connectivity manifold is used to guide an optimizer to find optimal field geometries in the IMRT treatment. To improve the visibility of insufficiently exposed voxels of planning target volumes (PTVs), a post-processing step may be performed to enlarge certain BEV regions, which are considered for exposing during treatment trajectory optimization.
US10946216B2	Incorporating multiple targets in trajectory optimization for radiotherapy treatment planning Methods of treatment trajectory optimization for radiotherapy treatment of multiple targets include determining beam's eye view (BEV) regions and a BEV region connectivity manifold for each target group of a plurality of target groups separately. The information contained in the BEV regions and the BEV region connectivity manifolds for all target groups is used to guide an optimizer to find optimal treatment trajectories. To improve the visibility of insufficiently exposed voxels of planning target volumes (PTVs), a post-processing step may be performed to enlarge certain BEV regions, which are considered for exposing during treatment trajectory optimization.
US10946215B2	Radiotherapy planning systems Embodiments of the present disclosure are directed to treatment planning systems for a radiotherapy apparatus. In one implementation, a treatment planning system may include a computational processor configured to apply a set of instructions to an input data set. The input data set may include a three-dimensional dose distribution for delivery by the radiotherapy apparatus to a volume to be irradiated, a three-dimensional volume image characterizing tissue types within the volume to be irradiated, and a set of apparatus parameters which characterize the radiotherapy apparatus. The set of instructions may include a computational process configured to output a treatment plan for delivery of the dose distribution by the radiotherapy apparatus, by optimising a function representing a time-dependent response of the tissue types to an applied radiation.
US10946212B2	Implantable device for optical stimulation of the brain The invention relates to an implantable device for optical stimulation of an organ of the human or animal body, having a probe comprising a tube made of a first transparent material, this tube being hermetically closed by at least one stopper; at least one light source arranged inside the tube; a plurality of electrical connection elements extending through the stopper and electrically connecting said at least one light source to the outside of the tube; and a linking cable arranged outside the tube and connected to said connection elements.
US10946211B2	Non-melatonin suppressing light source with a CRI that approaches that of white light The invention provides a lighting unit configured to generate white light wherein the white light has a spectral intensity in the visible wherein at least 40% of all photons in the wavelength range of 400-500 nm are found in the wavelength range of 430-445 nm (see also FIG. 1b). The lighting unit may especially be used for increasing alertness of a human while not or minimally suppressing melatonin production of the human.
US10946210B2	Cellulite and fat reducing device and method utilizing optical emitters A cellulite and fat reducing device and method utilizing optical emitters includes an array housing a plurality of optical emitters which are positioned to produce an optical output directed to a recipient, and a controller for instructing an operation of the array. The optical output being generated by a plurality of LED's cumulatively producing green light at approximately 529.6 nm, and at approximately 48,860 Lux, measurable at the array.
US10946208B2	Wearable cardioverter defibrillator (WCD) system using security NFC tag for requests of data from memory A wearable cardioverter defibrillator (WCD) system includes a processor, a memory, a wireless communication module (DWCM), and an NFC tag that stores information for how an accessing device may access the DWCM wirelessly. An accessing device such as a defibrillator configurator with an NFC reader may read the NFC tag of the WCD system, if it has adequate permission to do so. Upon so reading, the accessing device will know how to address the DWCM wirelessly, and thus install or update configuration data, software updates, or request memory downloads from operations. The use of the NFC tag requires close proximity, which hampers both inadvertently programming the wrong WCD system, plus a WCD system being attacked maliciously.
US10946207B2	Defibrillation waveforms for a wearable cardiac defibrillator An external defibrillator system is configured with at least two different algorithms for determining the duration of a shock administered to a patient being treated and selects the algorithm based on one or more patient parameters such as, for example, the patient's TTI. The patient's TTI can be measured prior to or while the shock is being administered to the patient. The shock can be, for example, a multiphasic defibrillation or a multiphasic cardioversion shock. The charge voltage of the system's energy storage device can additionally be varied depending on the one or more patient parameters. For example, the system may charge the energy storage device so that the charge voltage is higher or lower than a nominal charge voltage responsive to the patient's TTI is higher or lower compared to an average TTI, respectively.
US10946205B2	Implantable head mounted neurostimulation system for head pain An implantable head-mounted unibody peripheral neurostimulation system is provided for implantation in the head for the purpose of treating chronic head pain, including migraine. The system may include an implantable pulse generator (IPG) from which multiple stimulating leads may extend sufficient to allow for adequate stimulation over multiple regions of the head, preferably including the frontal, parietal and occipital regions. A lead may include an extended body, along which may be disposed a plurality of surface metal electrodes, which may be sub-divided into a plurality of electrode arrays. A plurality of internal metal wires may run a portion of its length and connect the IPG's internal circuit to the surface metal electrodes. The IPG may include a rechargeable battery, an antenna, and an application specific integrated circuit. The IPG may be capable of functional connection with an external radiofrequency unit for purposes that may include recharging, diagnostic evaluation, and programming.
US10946199B2	Neurostimulation method and system for active emulation of passive discharge in presence of MRI/EMI interference A neurostimulation system (NS) includes an array of electrodes positioned within a patient with an active cathode electrode located proximate to target neural tissue. A control circuit is controls delivery of therapy during a therapy delivery interval, with the therapy being delivered between an anode electrode and the active electrode. A current regulator circuit (CRC) is connected to the cathode electrode and controls current flow through the cathode electrodes. The control circuit manages the CRC to control a discharge current flow over the discharge operation to discharge developed residual voltage between the anode electrode and the active electrode in a manner that follows an actively emulated passive discharge (AEPD) profile. During the discharge operation, the CRC is connected to the inactive electrode, and receives, as a first input, an EMI feedback signal. The CRC regulates the discharge current flow through the active electrode based on the EMI feedback signal, to maintain the AEPD profile over the discharge operation during an EMI event.
US10946198B2	Arbitrary waveform generator and neural stimulation application with scalable waveform feature and charge balancing A method, device and/or system for generating arbitrary waveforms of a desired shape that can be used for generating a stimulation pulse for medical purposes such as for spinal cord stimulation therapy, including the option of using such arbitrary waveforms for charge balancing purposes.
US10946197B2	Treatment of conditions through modulation of the autonomic nervous system Methods are provided for treating a subject for a condition by modulating at least a portion of the subject's autonomic nervous system. In accordance with certain embodiments of the subject methods, at least a portion of a subject's autonomic nervous system is electrically or pharmacologically modulated in a manner that is effective to treat the subject for the condition. The subject methods find use in the treatment of a variety of different conditions, where such conditions include various disease conditions. Also provided are systems and kits for use in practicing the subject methods.
US10946195B2	System and method for ensuring airway patency when asleep One aspect of the present disclosure relates to a system that provides an alternative to traditional treatments for sleep apnea. The system allows to apply an electrical stimulus through an electrode to stimulate an afferent nerve fiber while a patient is sleeping. The system also includes activating an endogenous central nervous system (CNS)-regulated reflex response to coordinate upper airway muscles based on the stimulation of the afferent nerve fiber. Based on the endogenous CNS-regulated reflex response, an airway patency in the sleeping patient can be regulated.
US10946192B2	Device for radio frequency skin treatment The invention relates to a device (100) for RF skin treatment, comprising an active electrode (1) arranged on an operational side (15) of the device and having a first skin contact surface for contact with a skin of a user, which first skin contact surface has a largest cross-sectional dimension smaller than or equal to 2 mm. The device comprises a return electrode (2) arranged on the operational side (15) of the device and having a second skin contact surface for contact with the skin of the user, wherein an area of the second skin contact surface is at least five times larger than an area of the first skin contact surface. An RF generator (21) is arranged to supply an RF treatment voltage between the active electrode (1) and the return electrode (2) so as to heat a skin region below the active electrode, wherein the RF treatment voltage has a frequency in a range of 100 MHz-3 GHz. By using a frequency of the RF treatment voltage in said range, a depth of thermal lesions voltage is considerably increased as compared to RF skin treatment devices using a comparable RF treatment voltage, but at a much lower frequency.
US10946186B2	Systems and methods for making and using a lead introducer with a seal for an electrical stimulation system One embodiment is a lead introducer including an outer needle, an inner needle, a splittable member, and an annular seal member. The outer needle, inner needle, and splittable member each include a body and hub. The splittable member fits over the outer needle body and the inner needle body and can be separated longitudinally. The splittable member hub receives at least portions of both the inner needle hub and the outer needle hub within the splittable member hub. The annular seal member is formed by either a) the inner needle hub or b) a combination of the inner needle hub and outer needle hub. The annular seal member forms a fluid-resisting seal with the interior surface of the splittable member hub when the portions of the inner needle hub and outer needle hub are received within the splittable member hub.
US10946185B2	Topical neurological stimulation A topical nerve stimulator patch and system are provided including a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch; an electrical signal activation device; and a nerve feedback sensor.
US10946179B2	Gastrostomy tube reinsertion device The invention disclosed herein is a gastrostomy tube reinsertion device. The present invention provides a dilation device for dilating the gastrostomy tube tract in living tissues. In one aspect, the gastrostomy tube reinsertion device comprises multiple dilators to open collapsed soft tissue within the gastrostomy tube tract. Such device is useful for reinserting a gastrostomy tube into the previously defined tract in a human body, even after partial closure of the tract and gastrostomy tube insertion site. In another aspect, the present invention provides the method or steps for reinserting a gastrostomy tube into a patient.
US10946173B2	Hand-operated functional hose instrument A hand-operated functional hose instrument has a hose-like functional part and a wire-like functional part which extends in the hose-like functional part. An operating unit, which is designed for releasable coupling to an operator control handle body, is arranged at a proximal end section of the functional parts and includes two operating parts, which are axially relatively movable and have a hose fixing arrangement or a wire fixing arrangement. The first operating part is axially fixed to the operator control handle body, and the second operating part has a finger-operated operator control slide element. The first operating part has a finger-operated operator control rotary element and/or a distal cone section with an axial recess into which the second operating part can be at least partially inserted, and/or the wire fixing arrangement has two wire fixing parts which can be rotated in relation to one another about a longitudinal axis from a wire release position to a wire clamping position and each have an eccentric axial wire passage opening. The two passage openings are arranged axially one behind the other and are in alignment in the wire release position and are out of alignment in the wire clamping position.
US10946169B2	Medical kit, packaging system, instruction insert, and associated methods A Foley catheter kit includes a surface defining a single layer tray with at least two compartments at least partially separated by a barrier. A first syringe is disposed in a first compartment, while a Foley catheter, coupled to coiled tubing and a fluid drain bag, is disposed within a second compartment. The first compartment defines a lubricating jelly application chamber to lubricate at least a portion of the Foley catheter when the portion is passed from the second compartment to the first compartment. Printed instructions for using the single layer tray can be molded into the single layer tray.
US10946168B1	Smart urinary catheter A urinary catheter having a sensor or indicator affixed therein in a location that will be in the flow of urine when catheter is in use. The indicator comprises an electrolytic wicking material having an anode and a cathode thereon separated across the gap. The wicking material may be paper. The indicator further includes an output transducer positioned and connected relative to the anode and cathode such that a circuit which energizes the output transducer is created when urine flows. The indicator is configured to generate an output signal received at a remote location so that a medical practitioner can monitor proper usage of the catheter.
US10946165B2	Modulation of brainwave activity using non-invasive stimulation of sensory pathways Methods and apparatus for modulation of the central nervous system, and more particularly for modulation of brain oscillatory activity and the brain networks that give rise to it. The methods involve using one or more non-invasive stimuli, either alone or in combination, to increase, decrease, or otherwise modulate neural oscillations in the brain. Also described are methods and devices for detecting sub-optimal or pathological neural oscillatory patterns, developing treatment protocols to modify the neural oscillations in a desired manner, introducing a non-invasive stimulus or stimuli through one or more sensory pathways to treat the conditions, and adjusting the treatment protocol to improve the therapeutic effect of the stimulus or stimuli.
US10946164B2	Valve controlled high frequency oscillatory ventilation A breathing apparatus provides high frequency oscillatory ventilation [HFO] to a patient by supplying breathing gas to the patient according to an oscillating pressure profile oscillating between a positive pressure and a negative pressure. The breathing apparatus has a patient circuit including an inspiratory line for conveying breathing gas to the patient, and an expiratory line for conveying gas away from the patient, and an inspiration valve for regulating a flow of pressurised breathing gas into the inspiration line, and a control computer that controls the inspiration valve. The control computer operates to cause the oscillating pressure profile by controlling the inspiration valve to oscillate between a top flow position in which the flow of breathing gas through the inspiration valve assumes a top flow value, and a minimum flow position in which the flow through the inspiration valve assumes a minimum flow value.
US10946160B2	Medical vaporizer with carrier gas characterization, measurement, and/or compensation A medical vaporizer is provided. In one embodiment, dual-purpose sensors are employed, such as in a configuration in which one is positioned in the mixed gas flow channel and one is positioned in the main gas flow channel. The sensors provide measurements that may be used to determine both gas flow and gas concentration in the mixed and main gas channels, even when the identity and/or properties of the gas in the main gas channel are unknown. The measurements derived from the dual-purpose sensors may be used to measure and report the total anesthetic being delivered at the vaporizer output and/or improve vaporizer accuracy.
US10946156B2	Mask system A patient interface system includes a cushion and a frame that form at least part of a breathing chamber configured to receive the patient's nose. The patient interface system further includes headgear with a back portion and a pair of upper headgear straps extending from the back portion. In addition, a shroud is removably mounted on the frame and includes a pair of upper headgear connectors configured to connect to the pair of upper headgear straps. Each of the pair of upper headgear connectors comprises a rigidizer configured to be proximal to a nasal bridge region of the patient when donned by the patient. The pair of upper headgear straps are configured to be releasably attached to the pair of upper headgear connectors such that, when donned by the patient, the pair of upper headgear straps extend substantially parallel to the patient's Frankfort horizontal plane.
US10946155B2	Valsalva mask An interface for positive pressure therapy includes a mask assembly and a headgear assembly. The mask assembly comprises a mask seal that is adapted to underlie the nose. The mask seal extends up the lateral sides of the nose. The mask seal has a primary seal below the nose and a secondary seal alongside the nose.
US10946154B2	Gender based full-face mask sizes A respiratory mask for providing positive pressure therapy having ball jointed elbow, one or more detachable forehead pieces and headgear comprising a spacer fabric region is disclosed herein. The elbow is configured to be removable when oriented to a predetermined position. The forehead pieces are provided in one or more sizes. The spacer fabric region comprises two or more layers wherein the raw edges are turned to the inside of the layers. The seal comprises features that improves seal performance and accommodates a wider variety of facial geometries.
US10946153B2	Mechanical user control elements for fluid input module A cleaning catheter includes an inflatable element and an input module, which includes an inflation chamber coupled in fluid communication with the inflatable element. A flow regulator defines a suction port coupleable in fluid communication with a suction source. A mechanical suction-control button is configured to assume at least first and second spatial positions. A mechanical inflation-control button is configured to mechanically and non-electrically increase pressure in the interior of the inflation chamber during a transition of the mechanical inflation-control button from a first spatial position to a second spatial position; and a reversibly-engageable linking element, which is moveable with respect to the mechanical suction-control button and the mechanical inflation-control button, and is configured to assume at least a first spatial position, in which the linking element does not engage the mechanical suction-control button when the mechanical suction-control button is in its second spatial position; and a second spatial position.
US10946152B2	PC-based physiologic monitor and system for resolving apnea episodes during sedation An anesthesia delivery and monitoring system for use during outpatient surgery performed under sedation level anesthesia that includes a ventilatory system, a system for supplying sedation anesthesia, a respiratory sensor adapted to detect a respiration parameter of such a patient, and a system for supplying a timed back-up breath to such a patient through the ventilatory system. The timed back-up breaths are supplied in response to the respiration parameter falling outside a preset threshold and at a positive pressure exceeding a base operating pressure of the respiratory system. The system for supplying sedation anesthesia is an intravenous supply system for anesthesia, a ventilatory system coupled to the patient, a needle and syringe, or any combination thereof. The respiratory system includes a PC-based physiologic monitor with user modified feedback control signal.
US10946148B2	Method and apparatus for the production of microscale bubbles by depressurization cavitation A method and apparatus that enables the production of micron-scale free-standing bubbles made of liquids containing surfactants are provided. The method and apparatus of the invention overcomes the limitations of conventional bubble forming techniques by using a controlled cavitation process in a liquid media.
US10946142B2	Adapter element for fastening a needle tip to a syringe base body The invention relates to an adapter element for fastening a needle element to a syringe base body, the adapter element having a base body which is configured and provided for receiving the needle element, the base body having at least one through-opening for passing the needle element through and for fixing it, and the base body being configured and provided for being fastened to the syringe base body.
US10946141B2	Sterile protective cover comprising a device for opthalmic delivery Described herein does a sterile protective cover comprise an intracameral therapeutic agent delivery device in the form of a pen-injector comprising a cartridge container for dispensing multiple doses of a medicament, coupled to an actuation assembly within a housing. A needle assembly is coupled to the distal end of the cartridge container, provided with a removable cap received within the housing will be in optional pre-sterile or no-sterile condition. Use of such device for the prevention or treatment of ocular conditions or diseases is also disclosed. A sterile protective cover comprising ophthalmic device, wherein the sterile protective cover is made of plastic, polythene, polyethylene, resin, rubber, polystyrene, polypropylene, polycarbonate, nylon, or combination thereof. More, particularly the present invention relates to a novel ophthalmic device of reduced length and diameter in the form of a pen-injector for precise and controlled delivery of different doses of a therapeutic agent by introducing a unique “Pen grip” for the device. The present invention also depicts a novel ophthalmic device comprising a multimode power on-off button that would also work with a “Pulse mode” to deliver a fixed quantity of medicament and also double up as a speed control to control the rate of injection and might be used with dermal filler.
US10946140B2	Systems and methods for measurement of fluid delivery A test system for measuring a volume of fluid dispensed by a fluid infusion device includes a test housing. The test housing includes an inlet and an internal channel. The inlet is to be coupled to the fluid infusion device to receive the volume of fluid, and the internal channel is in fluid communication with the inlet. The test system includes an input electrode coupled to the internal channel to be in fluid communication with the volume of fluid, and an output electrode coupled to the internal channel to be in fluid communication with the volume of fluid. The test system includes a power source configured to create a voltage potential between the input electrode and the output electrode. The volume of fluid in the internal channel conducts current between the input electrode and the output electrode to facilitate measurement of the volume of fluid dispensed.
US10946137B2	Hybrid ambulatory infusion pumps Ambulatory infusion pumps, durable assemblies, and disposable assemblies, including energy sources, reservoirs, baseplates, and related components therefor, as well as component combinations and related methods.
US10946135B2	Nasal rinse tip A device for nasal lavage is described. The device ejects a gentle flow of fluid under pressure. The fluid stream provides a high quantity of fluid at low pressure. The low pressure fluid stream is more comfortable for a user than a high pressure fluid stream that is delivered by some types of pressurized cans of solution.
US10946127B2	Devices and methods for assisting cardiac function Devices and methods for assisting cardiac function. In an exemplary embodiment of a device for assisting heart function of the present disclosure, the device includes a first plate and an opposing second plate, each plate having an inner surface, a cardiac processor coupled to at least one of the first plate and the second plate, a bladder having an inner chamber and disposed between the inner surfaces, and a first catheter having a proximal end in communication with the inner chamber of the bladder and a distal end having a first pericardial balloon coupled thereto, wherein a gas and/or a liquid within the inner chamber of the bladder can be injected into the first pericardial balloon upon compression of the first plate relative to the second plate, and wherein the gas and/or the liquid can be removed from the first pericardial balloon upon retraction of the first plate relative to the second plate.
US10946124B2	Hybrid sealing tape A dressing for treating a tissue site with negative pressure is described. The dressing includes a tissue interface and a sealing member. The dressing further includes a sealing tape configured to be coupled to the sealing member and epidermis. The sealing tape includes a bonding adhesive and a sealing adhesive coupled to a side of the sealing tape. The sealing tape includes a layer of the bonding adhesive disposed on a film layer and a layer of sealing adhesive having one or more apertures disposed on the bonding adhesive. The sealing tape can include a layer of the bonding adhesive disposed on a portion of a film layer and a layer of the sealing adhesive disposed on a uncovered portions of the film layer.
US10946123B2	Corporeal drainage system A catheter connector assembly which may be included with a corporeal drainage system, and a method of draining fluid from a bodily cavity. The catheter connector assembly may include a catheter connector and a drainage line connector. The catheter connector may include a connector body with a coupling feature, a deformable sealing element, and a retaining member. The drainage line connector may include a drainage line body first and second hinge clips, and an actuator. The actuator is designed to deform the deformable sealing element when the drainage line connector is coupled to the catheter connector.
US10946120B2	Lubricious urinary catheters having varying flexibility A catheter having a shaft made from polyvinyl alcohol where in the shaft has a varying stiffness along the length of the shaft.
US10946119B2	Systems and methods for an advanced medical device The present invention relates to a biologically active medical device, which includes a matrix seeded with progenitor cells, and then covered by ciliated tissue. The matrix is capable of enabling cellular migration. The ciliated tissue is ependymal cells that express at least one of tight junctional complexes, zonula adherens, and gap junctions. The progenitor cells include subpendymal progenitor cells. In some cases the progenitor cells include stem cells, and the ciliated tissue includes at least one of Choroid cells, tanacytes, and circumventricular organs. In some embodiments, the medical device is oriented into a tubular structure in order to form a cerebrospinal shunt. Additional cells and structures may be imbedded within the matrix, such as glia, endothelial cells, stem cells, and blood vessels. The medical device may also be incorporated into a bioreactor including a flexible inner tube defining an anthropomorphically shaped lumen.
US10946112B1	Systems and methods for the production of gelled sanitizer compositions under extensional flow conditions Methods include producing a gelled sanitizer composition, including preparing a hydrating fluid composition including water and one or more of alcohol and peroxide; preparing a hydratable additive; and combining the hydrating fluid composition and the hydratable additive to produce a gelled composition. Methods also include flowing a hydrating liquid composition in an extensional flow regime through an elongated passageway of an extender, wherein the hydrating liquid composition includes water and a C2-C10 solvent, and a flow rate of the hydrating liquid composition and a diameter of the elongated passageway are sufficient to achieve a Reynolds number of 20,000 or greater; and adding a hydratable additive to the hydrating liquid composition in the elongated passageway to produce a mixture comprising the hydratable additive that is at least partially hydrated.
US10946109B2	Polymer-type fluorescent molecule probe The present invention provides a fluorescent molecular probe for efficient fluorescent detection (visualization) of tumors or for implementing fluorescent detection and photodynamic treatment, more specifically, the present invention provides a macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising a complex comprising a fluorescent molecule and a biocompatible macromolecule.
US10946106B2	Tumor-specific payload delivery and immune activation using a human antibody targeting a highly specific tumor cell surface antigen This invention provides antibodies directed against a highly specific and previously unrecognized marker for cancerous cells. In certain embodiments an isolated antibody or fragment thereof that specifically binds human placentally expressed ALPP and/or ALPPL2, but not ALPL and ALPI that are expressed outside the placenta is provided as well as immunoconjugates comprising such antibodies.
US10946105B2	Peptides derived from transient receptor potential cation channel subfamily M member 1 (TRPM1), complexes comprising such peptides bound to MHC molecules The present invention relates to novel peptides derived from Transient receptor potential cation channel subfamily M member 1 (TRPM1), complexes comprising such peptides bound to recombinant MHC molecules, and cells presenting said peptide in complex with MHC molecules. Also provided by the present invention are binding moieties that bind to the peptides and/or complexes of the invention. Such moieties are useful for the development of immunotherapeutic reagents for the treatment of diseases such as cancer.
US10946100B2	Polymers including active agents Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer and at least one visualization agent; and an active agent electrostatically bound to the polymer filament or chemically bound to the at least one monomer; wherein the polymer filament does not include metallic support members.
US10946095B2	Antibodies specific to human T-cell immunoglobulin and ITIM domain (TIGIT) Monoclonal antibodies that recognize TIGIT and inhibit its suppressive activity on T-cells are provided as well as pharmaceutical compositions including them and methods for their use in cancer immunotherapy and in diagnosis and treatment of immune disorders.
US10946094B2	Adenoassociated viral mediated persistant anti-VEGF therapy for ovarian cancer The invention provides a method of treating ovarian cancer in a patient by administering to the patient an adeno-associated virus (AAV) vector encoding an anti-VEGF antibody or antigen binding fragment thereof.
US10946092B1	Antibodies binding LAG3 and methods of treatment using them An isolated monoclonal antibody or an antigen-binding portion thereof that specifically binds human LAG3. A nucleic acid molecule encoding the antibody or antigen-binding portion thereof, an expression vector, a host cell and a method for expressing the antibody or antigen-binding portion thereof are also provided. The present disclosure further provides an immuneconjugate, a bispecific molecule, a chimeric antigen receptor, and a pharmaceutical composition comprising the antibody or antigen-binding portion thereof thereof, as well as a treatment method using the same.
US10946085B2	Streptococcus uberis extract as an immunogenic agent The present invention relates to an extract of Streptococcus uberis as an immunogenic agent. It also relates to a process for obtaining said agent which comprises incubating a biofilm-producing S. uberis strain to obtain a biofilm and thermally treating the biofilm obtained. It relates also to a pharmaceutical composition comprising teichoic acids, preferably lipoteichoic acids, for use in the prevention and/or treatment of mastitis and/or infections caused by Streptococcus sp. or by biofilm-producing bacteria. The present invention also relates to a vaccine which comprises said immunogenic agent and to said vaccine and immunogenic agent for use in the prevention and/or treatment of infections caused by Streptococcus sp., especially in the prevention and/or treatment of mastitis caused by S. uberis. It also relates to a vaccination kit which comprises said agent or vaccine.
US10946082B2	Immunomodulatory compositions and methods of use thereof The present disclosure provides immunomodulatory compositions comprising heat-killed Caulobacter crescentus (HKCC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising HKCC to the individual.
US10946074B2	GLP-1 derivatives and uses thereof The invention relates to GLP-1 analogues and derivatives having a Trp at a position corresponding to position 8 of GLP-1(7-37), and their pharmaceutical use e.g. in the treatment of type 2 diabetes. These Trp8 compounds are very stable against degradation by DPP-IV, while maintaining the capability to bind to and activate the GLP-1 receptor. The derivatives have one or two substituents (P-L) attached to a Lys residue of the GLP-1 analogue via an optional Branching group (B), wherein P is a Protracting moiety such as a fatty diacid, and L is a linker consisting of one or more linker elements such as, for example, 8-amino-3,6-dioxaoctanoic acid. Examples of compounds of the invention include the 8W variants of liraglutide and dulaglutide. The invention also relates to a method for the fully recombinant preparation of 8W GLP-1 analogues and derivatives which is more simple and thereby cheaper as compared to the preparation of known GLP-1 analogues that have been DPP-IV stabilised by inclusion of one or more non-coded amino acids.
US10946073B2	GHRH or analogues thereof for use in treatment of hepatic disease The present application relates to novel methods for preventing, slowing the progression of, or treating nonalcoholic fatty liver (NAFL), nonalcoholic steatohepatitis (NASH), and/or liver fibrosis, and/or reducing the risks of liver cancer in subjects, such as HIV-infected subjects, using a GHRH molecule, e.g., trans-3-hexenoyl-GHRH(1-44)-NH2, or a pharmaceutically acceptable salt thereof. The subjects may have particular pathological features such as liver fibrosis, a hepatic fat fraction (HFF) of at least about 10%, serum alanine aminotransferase (ALT) levels of at least about 30 U/L, and/or a NAFLD Activity Score (NAS) of at least 4 or 5.
US10946067B2	Compositions and methods for treating pulmonary hypertension In some aspects, the disclosure relates to GDF/BMP antagonists and methods of using GDF/BMP antagonists to treat, prevent, or reduce the progression rate and/or severity of pulmonary hypertension (PH), particularly treating, preventing or reducing the progression rate and/or severity of one or more PH-associated complications. The disclosure also provides methods of using a GDF/BMP antagonist to treat, prevent, or reduce the progression rate and/or severity of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, and right ventricular hypertrophy. The disclosure further provides methods of using a GDF/BMP antagonist to reduce right ventricular systolic pressure in a subject in need thereof.
US10946065B2	Methods of treating fungal infections The invention relates to methods of treating a fungal infection in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a composition comprising one or more antifungal peptides selected from the group consisting of BmKn2, dBmKn2, Kn2-7, and dKn2-7. Antifungal pharmaceutical compositions and dosage forms, including field-deployable dosage forms, comprising one or more of these antifungal peptides are also contemplated herein.
US10946063B2	Fusion protein between short form rod-derived cone viability factor and a hydrophilic peptide A fusion protein is described, comprising a first N-terminal signal peptide sequence, a second peptide sequence C-terminal to the signal peptide sequence, and a third peptide sequence C-terminal to the second peptide sequence; wherein one of the second peptide sequence and the third peptide sequence is an RdCVF-short peptide sequence and the other is a hydrophilic peptide sequence. After translation the signal peptide is cleaved, leaving a fusion protein comprising the second peptide sequence and the third peptide sequence minus the signal peptide. Also described are nucleic acids and expression vectors encoding the fusion protein, cells comprising the nucleic acid or expression vector, as well as methods of treatment and uses of the fusion protein, nucleic acid, and expression vector. The fusion protein can be produced in vitro by culturing the cells of this invention under conditions allowing for expression and secretion of the encoded fusion protein, and isolating the fusion protein from the cell culture.
US10946061B2	Peptide inhibitors of twist The disclosure provides, inter alia, compositions comprising TWIST peptide inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer.
US10946060B2	Pharmaceutical composition containing ATPIF1 for treatment of diabetes The present invention relates to a pharmaceutical composition containing ATPase inhibitor factor 1 (ATPIF1) as an active ingredient for the prevention or treatment of diabetes or diabetic complications, and to a pharmaceutical composition containing ATP1F1 as an active ingredient for prevention or treatment of obesity. The composition containing ATPIF1, according to the present invention, has a diabetes treatment effect by promoting sugar absorption in muscle cells and improving insulin sensitivity, and has an obesity prevention or treatment effect by effects of suppressing fat synthesis in fat cells and promoting the browning of fat cells.
US10946058B2	Food additives and methods of making and using same Described herein are food additives prepared from the inner core of a banana plant stem, along with methods of making and using same.
US10946056B2	Inhibition of formation of amyloid b-protein fibrils using cactus mucilage extracts A method of slowing progression of an amyloid disease by administration of cactus mucilage extract from Opuntia ficus-indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of Aβ fibrils and aggregation of Aβ fibrils into plaques.
US10946053B2	Composition containing mixed extract of mulberry and Poria cocos bark for preventing, improving or treating neurodegenerative disorders The present invention relates to a composition comprising the mixed extract of mulberry and Poria cocos peel for preventing, improving or treating neurodegenerative disorders. The mixed extract of mulberry and Poria cocos peel which is the active ingredients contained in the composition of the present invention, has a memory improving activity through inhibiting of acetylcholine esterase and a neuroprotective effects and neuron protection by inhibiting the formation of beta amyloid and tau phosphorylation and promoting NGF production. Thus, the present invention may be useful as a pharmaceutical composition for preventing or treating degenerative neurological diseases, or as a health food for the above purpose.
US10946052B2	Nutritional composition The present invention provides nutritional compositions that are employed as oral supplementation to the human diet. The compositions of the present invention provide for supplementation to the diet of the cancer patient, as well as preventative dietary supplementation aimed at supporting the human immune system for those not currently suffering from cancer. The present invention is comprised of specific combinations of selected forms selenium, chromium, and molybdenum in c combination with a fish oil.
US10946051B2	Strain of Bifidobacterium animalis subsp. lactis CECT 8145 and use thereof for the treatment and/or prevention of excess weight and obesity and associated diseases The invention is applicable within the food and pharmaceutical industry. More specifically, it relates to a novel strain of the species Bifidobacterium animalis subsp. lactis CECT 8145, the cell components, metabolites and secreted molecules thereof, which, incorporated into food and/or pharmaceutical formulations, can be used in the treatment and/or prevention of excess weight and obesity and related diseases such as metabolic syndrome, hypertension, glycemia, inflammation, type 2 diabetes, cardiovascular diseases, hypercholesterolemia, hormonal alterations, infertility, etc.
US10946048B2	Use of gram negative species to treat atopic dermatitis Pharmaceutical compositions are disclosed that includes a therapeutically effective amount of a purified viable gram negative bacteria and a pharmaceutically acceptable carrier. The pharmaceutical compositions are formulated for topical administration. Methods of treating atopic dermatitis using these pharmaceutical compositions are also disclosed.
US10946046B2	Method for sterilising a platelet lysate A method for sterilising a platelet lysate in the liquid state comprising at least the endogenous growth factors TGF-beta 1, EGF, PDGF-AB, IGF-1, VEGF and bFGF. The method comprising freezing the liquid platelet lysate in order to obtain a frozen platelet lysate, and irradiating the frozen platelet lysate with ionising radiation in order to obtain a sterilised platelet lysate, the irradiation being adapted so as to preserve at least 80% of the concentration of at least one of the endogenous growth factors chosen from the group consisting of TGF-beta 1, EGF, PDGF-AB, IGF-1 and VEGF.
US10946045B2	Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.
US10946043B2	Methods of mediating macrophage phenotypes Methods of inducing a polarization of macrophages. The method includes obtaining a blood fraction, fractionating the blood fraction to produce a blood fraction, and contacting the blood fraction with a source of macrophages. A blood fraction including platelet-poor plasma polarizes the source of macrophages into M1 macrophages. A blood faction including a protein solution polarizes the source of macrophages into M2 macrophages.
US10946042B2	Compositions and methods for selective phagocytosis of human cancer cells The present invention relates to compositions and methods that provide novel therapies in cancer. The invention includes a phagocytic cell modified with a repressor of signal regulatory protein-alpha (SIRPα) and bound to a targeting antibody to enhance phagocytic activity of the phagocytic cell toward tumor tissue. Methods of enhancing phagocytic activity and treating a tumor are also included.
US10946035B2	Production of stable non-polyadenylated RNAs The invention relates in aspects to hybrid RNAs lacking a poly-A tail and nucleic acid vectors for expressing the RNA. The hybrid RNAs in some instances have a stabilizing triple helical structure. Related methods for expressing RNA in vivo and in vitro are also disclosed.
US10946033B2	2′-substituted-N6-substituted purine nucleotides for RNA virus treatment The use of described compounds or pharmaceutically acceptable salts or compositions thereof for the treatment of a host infected with an RNA virus other than HCV, or other disorder more fully described herein.
US10946030B2	Formulations of deoxycholic acid and salts thereof The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.
US10946028B2	Polymer conjugate of sulfoxide derivative-coordinated platinum(II) complex A DDS preparation of a platinum complex, which exhibits a superior antitumor effect required as a medicine and reduced side effects, that is, a clinically usable DDS preparation of a platinum complex, which is conjugated to a polymer carrier that is different from conventional carriers, is desired.Provided is a polymer conjugate of a platinum(II) complex, the polymer conjugate including: a block copolymer having a polyethylene glycol structural moiety and a polyaspartic acid moiety or a polyglutamic acid moiety; a sulfoxide derivative introduced into a side-chain carboxyl group of the block copolymer; and a platinum(II) complex coordinate-bonded to a sulfoxide group of the sulfoxide derivative.
US10946024B2	Method for treating cancer The present invention provides a method for treating or alleviating a symptom of a disorder, e.g., immune evasion, cancer-cell induced immune dysfunction, reduced immune response, lowered inflammation, decreased expression of a major histocompatibility complex (MHC), or cancer, characterized by aberrant, misregulated, or increased Enhancer of Zeste Homolog 2 (EZH2) activity in a cell or subject in need thereof by contacting the cell or administering to the subject a therapeutically effective amount of an EZH2 inhibitor.
US10946023B2	Therapeutically active compounds and their methods of use Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
US10946022B2	Imipridones for gliomas Imipridones selectively modulate Class A G protein-coupled receptors (GPCRs), such as the D2-like subfamily of dopamine receptors, and are useful for treating conditions and disorders in need of such modulation, such as cancers. Specifically, the cancer is a midline glioma, a cancer having a histone H3 mutation, or both. In addition, methods of identifying whether a subject having these conditions, is likely to be responsive to a treatment regimen, such as imipridone administration, are provided. Furthermore, methods of assessing the effectiveness of a treatment regimen, such as imipridone administration, monitoring, or providing a prognosis for a subject with these condition are also provided.
US10946017B2	Tank-binding kinase-1 PROTACs and associated methods of use The present invention relates to bifunctional compounds, which find utility to degrade and (inhibit) TBK1. In particular, the present invention is directed to compounds, which contain on one end an E3 ubiquitin ligase binding moiety which binds to an E3 ubiquitin ligase and on the other end a moiety which binds TBK1 such that TBK1 is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of TBK1. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of TBK1.
US10946016B2	Solid forms of an epidermal growth factor receptor kinase inhibitor The present invention provides a solid form and compositions thereof, which are useful as an inhibitor of EGFR kinases and which exhibit desirable characteristics for the same.
US10946015B2	Stable pharmaceutical compositions comprising a pyrimidine-sulfamide The invention relates to stable pharmaceutical compositions comprising the compound of the below formula, or pharmaceutically acceptable salts, solvates, hydrates or morphological forms thereof.
US10946013B2	Methods for treating central nervous system disorders using vdac inhibitors The present invention relates to use of small organic compounds interacting with the Voltage-Dependent Anion Channel (VDAC) for the treatment of diseases associated with central nervous system (CNS) disorders, including psychotic disorders, mood disorders, neurodegenerative diseases. In particular the present invention relates to the use of substituted piperazine- and piperidine-derivatives and pharmaceutical compositions comprising same for the treatment of psychotic disorders including schizophrenia, mood disorders, and neurodegenerative diseases.
US10946010B2	Abuse-resistant pharmaceutical composition for the treatment of opioid dependence There is provided pharmaceutical compositions for the treatment of e.g. opioid dependency comprising microparticles of a pharmacologically-effective amount of buprenorphine, or a pharmaceutically-acceptable salt thereof, in associative admixture with particles comprising a weak acid, or particles comprising weakly-acidic buffer forming materials. The composition may further comprise a disintegrant and/or particles of a pharmacologically-effective amount of naloxone, or a pharmaceutically-acceptable salt thereof. The compositions are useful in the treatment of opioid dependency/addiction and/or pain.
US10946008B2	Treatment of pemphigus The present disclosure provides methods of treating with a BTK inhibitor a blistering disease, in particular pemphigus vulgaris or pemphigus folliaceous in a mammal, use of a BTK inhibitor as a replacement therapy for corticosteroid therapy for diseases treatable with a corticosteroid, such as autoimmune or inflammatory disease and in particular where corticosteroids are used as first or second line therapy, and pharmaceutical formulations comprising the same.
US10945997B2	Polymer derivative of macrolide immunosuppressant An object of the invention is to obtain a preparation which shows enhanced effectiveness and safety compared to tacrolimus, has the concentration in blood maintained at a constant level without individual differences, whereby the control of the amount of administration depending on the blood kinetics (blood trough concentration) becomes unnecessary. The present invention relates to a polymeric derivative of tacrolimus, in which a polyethylene glycol segment and an alcoholic hydroxy group of tacrolimus are bonded to side-chain carboxy groups of a polyaspartic acid derivative.
US10945993B2	Methods of recruiting SDF-producing macrophages The present invention relates to the field of wound healing. More specifically, the present invention provides methods and compositions useful for improved wound healing via autologous stem cell mobilization. In one embodiment, a method for improving wound healing in a patient comprises administering to the patient a therapeutically effective amount of a stem cell mobilizer and a low dose of an immunosuppressive agent.
US10945989B2	Perinatal treatment with a flavonoid agonist of the TrkB receptor for BDNF rescues neurogenesis and behavior in the Ts65Dn mouse model of DS The present invention relates to methods of restoring brain development in individuals with Down syndrome with a flavone derivative, 7,8-dihydroxyflavone (7,8-DHF).
US10945984B2	Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects Methods of reducing undesirable side effects during therapeutic treatment using monomethyl fumarate and prodrugs of monomethyl fumarate are disclosed.
US10945980B2	Treatment for myopia Provided herein are methods for treating or preventing myopia, or for inhibiting the development of myopia, comprising administering to a subject in need thereof an effective amount of an agent capable of increasing nitric oxide levels in one or more ocular cells or an agent capable of promoting or increasing the expression and/or activity of nNOS in one or more ocular cells. Also provided are methods for inducing or promoting nNOS expression and/or activity in one or more ocular cells, comprising exposing said cells to an effective amount of L-arginine.
US10945979B1	Amino acid compositions to promote endothelial health Amino acid compositions for promoting vascular endothelial health include arginine, citrulline, and taurine. Compositions may be combined with additional ingredients to form beverages, concentrates, and non-liquid food compositions. Methods of making concentrate compositions, beverage compositions, and non-liquid food compositions are provided. Methods of administering compositions to improve endothelial health, treat endothelial dysfunction, treat sexual dysfunction, treat altitude sickness, treat decompression sickness, treat jet lag, and treat fatigue include administering compositions including arginine, citrulline, and taurine.
US10945977B1	Non-surgical laser treatment for a fibrous mass Systems and methods for treating a fibrous mass, which is comprised of a Morton's neuroma, are disclosed. In one exemplary implementation, a method may comprise identifying a location of the fibrous mass and non-surgically delivering electromagnetic energy to the fibrous mass. Embodiments may include delivering the energy via a Nd:Yag laser at various specified parameters, such as spot size, power/fluence, frequency, duration, pulse characteristics, and/or tissue depth, among others.
US10945976B2	Autoimmune disorder treatment using RXR agonists The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.
US10945973B2	Bupropion as a modulator of drug activity Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
US10945971B2	Sphingosine kinase type 1 inhibitors and uses thereof Provided are inhibitors of sphingosine kinase Type I that are useful in a number of applications, indications and diseases, as well as for monitoring pharmacokinetics and patient management. These compounds are applicable to treating ischemic diseases such as myocardial infarction and stroke.
US10945968B2	Memantine transdermal delivery systems Transdermal delivery systems for the systemic delivery of memantine are described, wherein the system comprises a drug reservoir layer and an adhesive layer, optionally together with one or more intermediate and/or supporting layers, wherein the drug reservoir layer comprises an acrylate polymer or copolymer, a permeation enhancer, a carrier, and memantine base generated in situ by reaction of a memantine salt and an alkaline salt. Compositions and kits comprising the various components, e.g., drug reservoir and/or adhesive compositions are described. Methods relating to treatment of CNS disorders, e.g., Alzheimer's disease and/or dementia, using the aforementioned transdermal delivery devices and/or compositions are also described.
US10945967B2	Formulations of a transdermal patch for pain management Various formulations (to be used in the form of a single-segment or multi-segment transdermal patch) of bioactive compounds for pain management are described/disclosed. The multi-segmented transdermal patch can include one or more compatible bioactive compounds in each segment. Furthermore, formulations may include silk fibroin and/or microemulsion/nanoemulsion of bioactive compounds and/or microencapsulation/nanoencapsulation of bioactive compounds.
US10945966B2	PEGylated lipid nanoparticle with bioactive lipophilic compound The invention relates to nanoparticles for the systemic or topical delivery of lipophilic diagnostic or therapeutic agents to a subject in need thereof. The nanoparticles of the invention comprise a water soluble polymer and at least one of a biocompatible lipid and a lipophilic agent. The invention further relates to ophthalmic treatment using the nanoparticles of the invention. In addition, the invention pertains to compositions and formulations comprising the nanoparticle of the invention. Such formulation may be an eye drop formulation.
US10945963B2	Photosensitive capsules and cosmetic and pharmaceutical use thereof The invention relates to capsules of core/shell type, the core comprising an active agent; the shell comprising one or more concentric and alternating layers of a first photosensitive anionic amino polymer and of a second cationic polymer. The invention also relates to a cosmetic or pharmaceutical composition comprising such capsules. The invention also relates to a non-therapeutic cosmetic process for treating keratin materials, comprising the application to the keratin materials of a cosmetic composition comprising the said capsules, followed by exposure of the deposit formed on the keratin materials to natural light or to artificial light with a wavelength of between 360 and 600 nm.
US10945959B2	System and method for freeze-drying and packaging A system and method for freeze-drying a heat-sensitive substance. In some embodiments, the system and method include freeze-drying the heat-sensitive substance in an upright container with a membrane for transmitting air or vapor solvent out of the container.
US10945958B2	Dexamethasone prodrug compositions and uses thereof The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.
US10945955B2	Artificial exosome composition and related methods Novel artificial exosomes and methods for producing novel artificial exosomes are provided. Methods of delivering cargo molecules to a cell using artificial exosomes are also provided.
US10945953B1	Controlled release core-shell particles and suspensions including the same Provided is a composition including a dispersion medium including: an aqueous solution; a first active ingredient; a flavor agent; and a first type of polymer; and a dispersed phase including: a population of particles, each particle including: a core including: a second active ingredient a second type of polymer; and an aqueous solution; a shell, substantially surrounding the core, the shell including: a third type of polymer; a plurality of lipophilic carriers; and a third active ingredient; and a plurality of emulsifying agents.
US10945952B2	Rinse-off compositions and uses thereof for delivery of active agents The present application relates to a rinse-off composition comprising an oil phase and an aqueous surfactant matrix, wherein one or more active agents are dissolved in one or more non-polar, water-immiscible solvents, and the oil phase is dispersed in the aqueous surfactant matrix. The present application also relates to methods of delivering the active agent(s) to a subject in need thereof topically, for example to the skin, the hair, and scalp. The present application also relates to use of the rinse-off compositions to treat and/or prevent topical conditions such as dermatitis and psoriasis. In some embodiments, the rinse-off compositions of the present application are shampoo compositions.
US10945947B2	Formulations for intravenous administration The present invention relates to an improved formulation of danirixin in its hydrobromide salt form. This improved formulation can be an aqueous intravenous formulation containing danirixin or a lyophilized pharmaceutical solid composition containing danirixin to be reconstituted to provide a solution for intravenous administration.
US10945946B2	Synthesis and application of microbubble-forming compounds The present disclosure is directed to fatty-acid glycerol ester derivative compounds containing a targeting bisphosphonate group. The disclosure further include pharmaceutical or biomedical compositions comprising these compounds, and methods of using these compounds and compositions forming microbubbles. The microbubbles have affinity for metal-containing, especially calcium-containing, bodies and/or biological targets. In certain embodiments, these compositions are useful for providing targeted placement of microbubbles capable of cavitation on application of high frequency energy.
US10945941B2	Powerful hair treatment agent with anti-washout effect Hair treatment agents are provided herein. The hair treatment agent contains at least one fatty alcohol; at least one cationic surfactant; at least one divalent or trivalent metal salt; at least one silver salt selected from silver acetate, silver adipate, silver citrate, silver galactarate, silver gluconate, silver lactate, silver malate, silver mandelate, silver salicylate, silver succinate, silver sulfate, and silver tartrate; and at least one organic acid selected from adipic acid, succinic acid, citric acid, acetic acid, galactaric acid, gluconic acid, hydroxysuccinic acid, mandelic acid, lactic acid, salicylic acid, sulfuric acid, and tartaric acid. The hair treatment agent reduces or prevents the fading of color from dyed hair.
US10945938B2	Lactone-containing compositions for malodor elimination The presently disclosed subject matter provides lactone-containing malodor eliminating compositions that ameliorate undesirable malodor, e.g., undesirable malodor due to presence of sulfur- or amine-containing compounds. The presently disclosed compositions can be added to a variety of products, including, but not limited to, foods, beverages, toothpastes, mouthwashes and other orally consumable products.
US10945929B2	Anhydrous compositions and articles for makeup removal Makeup removal compositions include at least one branched, alkylated alcohol ester; one or a combination of dialkylated ether and dialkylated carbonate; at least one nonionic surfactant; and at least one vegetable derived oil, wherein the composition is essentially free of water. Articles include the composition infused in a water-insoluble or water-soluble substrate.
US10945928B2	Denture base coating composition, coating film-bearing denture base, plate denture, and method for producing coating film-bearing denture base A denture base coating composition includes at least one selected from the group consisting of a first compound represented by Formula (1-0) and a second compound represented by Formula (2-0).
US10945922B1	Apparatus for creating a sealed conduit between separate volumes An apparatus for creating a sealed conduit between separate volumes includes a first unit and a second unit. The first unit includes a housing defining a first volume, a conduit, and at least one first penetrable interface. The at least one first penetrable interface is reconfigurable from a closed, sealed, condition when not penetrated by the conduit to a sealed condition with the conduit passing therethrough when penetrated by the conduit. The second unit includes a housing defining a second volume and at least one second penetrable interface.
US10945920B2	Vial stabilizer base with vial adapter A system includes a vial stabilizer base having a first body and a plurality of fingers projecting from the first body, with the plurality of fingers being annularly disposed about the first body, and a vial adapter having a second body and a plurality of arms projecting from the second body. The second body defines a passageway. The plurality of fingers of the vial stabilizer base defines a socket having a first seat configured to receive a vial and a second seat configured to receive the vial adapter.
US10945919B2	Cryocassette Methods, apparatus, and device, such as a blood bag envelope, that protects a blood bag during storage and/or transport. The blood bag envelope holds a blood bag or a metal cassette that contains the blood bag. The envelope includes multiple panels. The multiple panels include a top panel, a first edge panel, a second edge panel, a front panel and a bottom panel. The multiple panels are configured to fold to form the enclosure to hold the blood bag. The envelope includes a first fastening device connected to an inner surface of the top panel. The envelope includes a suspension device that is suspended from the first fastening device. The suspension device is configured to suspend the blood bag within the enclosure when the multiple panels are folded to form the enclosure.
US10945904B2	Tilt mechanisms for medical systems and applications A robotic medical system can include a patient platform. The patient platform includes a tilt mechanism. The tilt mechanism can include a lateral tilt mechanism and a longitudinal tilt mechanism. The lateral tilt mechanism can include a tilt plate and a pivot housing. A linear actuator mounted on the tilt plate can apply a linear force to the pivot housing. The lateral tilt mechanism can also include a first linear guide that extends along a first axis, and the pivot housing can translate along the first linear guide. Application of the linear force to the pivot housing tilts the tilt plate by causing the pivot housing to translate along the first linear guide.
US10945900B1	Powered wheelchair for beach terrain A powered wheelchair for beach terrain is provided that includes a an occupant seat assembly mounted to a frame that has an electric drive system with a pair of electric motors mounted thereto. A hand grip support frame is coupled to a rear end of the frame. The electric drive system is drivingly coupled to at least two of a plurality of wheels rotatably mounted to the frame. The powered wheelchair includes a portable power source and a control system mounted to the main frame. The control system is electrically coupled to the portable power source and the electric drive system. The control system has a first set of operating controls disposed in proximity to the occupant seat assembly and a second set of operating controls disposed in proximity the hand grip support frame for switch selective operative control of the powered wheelchair.
US10945898B2	Two point wheelchair securement system The embodiments described and claimed herein are improved wheelchair passenger securement systems and stations. In particular, one embodiment described and claimed herein is a drop-in system comprising a barrier module and a wall-side module, which incorporate two separate restraint devices which are configured to secure a wheelchair at two separate attachment points and a bumper. The system can optionally include a moveable excursion barrier or a pull-mechanism to pre-tension at least one of the restraint devices the wheelchair securements. In a simpler embodiment, a bumper and two restraint devices, such as retractors, are provided for attachment to the vehicle surfaces or structures at a wall side of a wheelchair securement area or at a rear side of the wheelchair securement area.
US10945897B2	Wheelchair securement system and device The restraint and retractor assembly described and claimed herein are for securing a wheelchair to a support while the wheelchair is in transit. In one embodiment, the system includes at least one securement assembly having a configuration in which a portion of the wheelchair is secured in the vehicle. In this embodiment, the securement assembly includes a retractor secured to the vehicle and a restraint that has both of its ends secured to or near the retractor and a middle segment extends to and from a spool in the retractor, a middle segment is connected to the wheelchair by a connector and passes through an opening in the connector, providing a double length of flexible webbing to secure the wheelchair to the support surface.
US10945890B2	Manufacturing method for absorbing body A method for manufacturing an absorbent body according to the present invention includes a first step of successively introducing an aggregate of absorbent fibers and a water-absorbent resin into a gap that is formed between a first surface and a second surface and is smaller than a thickness of the aggregate of the absorbent fibers, recesses and protrusions being formed on at least one of the first surface and the second surface, a second step of applying a shearing force to the aggregate of the absorbent fibers by moving the first surface relative to and parallel to the second surface in order to mix the absorbent fibers and the water-absorbent resin, and a third step of causing the absorbent fibers and the water-absorbent resin that were mixed to fall, and stacking the absorbent fibers and the water-absorbent resin by suctioning the absorbent fibers and the water-absorbent resin into a recessed portion having a predetermined shape.
US10945889B2	Releasable medical drapes A releasable medical drape, and systems and methods having the same, includes at least a liquid-impermeable, vapor-permeable layer, a pressure-sensitive adhesive layer, and a soft-gel layer having a plurality of apertures. The soft-gel layer is configured to be disposed adjacent to a tissue site. A portion of the pressure-sensitive adhesive layer extends through the plurality of apertures in the soft-gel layer to contact the tissue site. The soft-gel layer forms a good seal with the tissue site and the pressure-sensitive adhesive layer extending through the plurality of apertures forms a firm—but releasable—coupling with the tissue site.
US10945887B2	Method and system for an accelerated reaction of darkening of the optical device in personal protective equipment System has an optical sensor (1), an aperture with the optical element (2) with the changeable permeability and an activation light (3) emitting radiation, which is detected by the optical sensor (1). The activation light is connected with the switch (4) and it is placed within the reach of the optical sensor (1). Within a device which realizes the technological process with the luminous manifestation the instruction for the beginning of a given technological process is detected and on the basis of this instruction the activation light (3) lights up. This activates the optical sensor (1) by means of the activation light (3) before the optical sensor (1) detects the luminous manifestation of the technological process itself. The activation light (3) can be a simple infrared LED diode. The advantage lies in the fact that the protective device itself does not have to be modified in any way and its reaction time can be shortened to zero, or negative reaction time can be achieved since we use time passing during the initiation of the technological process before the appearance of the luminous manifestation for the darkening.
US10945883B2	Ocular implants, inserter devices, and methods for insertion of ocular implants Intraocular drainage devices, intraocular implantation procedures, and inserter devices for intraocular implantation procedures are disclosure. A disclosed intraocular drainage device includes a tube having a distal end and a body disposed proximal to the tube. An inlet port is disposed on the distal end of the tube and configured to receive an influent fluid from an anterior chamber of an eye. An inlet fluid pathway is coupled to the inlet port and extends at least partially through the tube. A plurality of outlet fluid pathways extend at least partially through the body and branch from the inlet fluid pathway. A plurality of outlet ports are disposed on the body and coupled to the plurality of outlet fluid pathways. A disclosed inserter device for an ocular implantation procedure includes a handle, a needle, and a plunger. The needle is disposed on a distal end of the handle and configured to hold an intraocular drainage device. The plunger is coupled to the needle and disposed in the handle. The plunger is disposed distal to a vacuum chamber within the handle and configured to retract the needle based on a proximal force applied by the vacuum chamber.
US10945881B1	Plural-use drop-by-drop dispenser for sterile liquid product, particularly for collyrium or other medicinal product or medical device A plural-use drop-by-drop dispenser for sterile liquid product comprises a vial (1) for containment of the liquid product (2) and a connector (4) provided with a plug (8) which is normally hermetically closed and with a cartridge (19) with sterilizing filter (24) which can be axially moved to force open said plug (8) to dispense the liquid product and allow the hermetic reclosure thereof at the end of dispensing. The cartridge (19) is provided with a filter-holding bottom element (25) provided with a dispensing spout (26), possibly in antimicrobic material, with elastically flexible converging lips (27), which open under pressure of the liquid product (2) for drop-by-drop dispensing thereof and elastically hermetically reclose at the end of the dispensing operation.
US10945878B2	Dual modality energy delivery system A dual modality system includes a chassis having a receptacle and means to couple the chassis to a desired treatment area of a user's body; a durable energy subsystem coupled to the chassis, arranged and configured to deliver energy to the desired treatment area of a user's body; and a replaceable thermal subsystem arranged and configured for removable placement in the receptacle of the chassis, arranged and configured to deliver thermal energy.
US10945877B2	Thermoregulating gelpack A gel-pack has a plurality of self-contained components organized as layers in an interior chamber of the gel-pack. Each layer may be inserted into, and removed from, the interior chamber individually. The components include a solid-state gel layer that stores thermal energy, a first radiant energy barrier that prevents the transfer of thermal energy radiating from an exterior of the gel-pack into the solid-state gel layer, and a second radiant energy barrier that reflects the thermal energy radiating from the user's body into the solid-state gel layer.
US10945871B2	Orthotic leg support apparatus An orthotic apparatus includes a leg securing member adapted for attachment to a wearer's lower leg. A resilient strut that flexes in the anterior to posterior direction has an upper end connected to the leg securing member. A heel member is connected to the strut lower end at the heel member. A foot member is connected to the heel member. The foot member has a heel end at the heel member and a toe end spaced horizontally from the heel end. The foot member also has a substantially rigid lower foot plate extending between the heel end and toe end and a substantially rigid upper foot plate extending between the heel end and toe end above and generally parallel to the lower foot plate. In certain examples the orthotic apparatus is integrated with a shoe.
US10945870B2	Apparatus for treating obesity An volume filling device for treatment of obesity is placed outside the stomach wall of the patient to reduce the inner volume of the stomach, thereby affecting the patient's appetite. By providing the volume filling device outside the stomach wall, contact with stomach acids is avoided, thereby increasing the life of the device.
US10945868B2	Thin-film micromesh and related methods Thin-film mesh for medical devices and related methods are provided. The thin-film mesh may include slits to be expanded into pores, and the expanded thin-film mesh may be used as a cover for a stent device. The thin-film mesh has a tube-shape and the slits may be angled with respect to a longitudinal axis of the tube-shape thin-film mesh. The angled slits allow for the thin-film mesh to expand in multiple dimensions, including along the longitudinal axis and along the circumferential direction of the tube-shape thin-film mesh. The slits may be provided in diagonal rows arranged in longitudinal columns. Longitudinal columns of different types of slits may be arranged along the circumferential direction on the tube-shape thin-film mesh to form a zig-zag pattern of slits. The thin-film mesh may be formed from thin-film Nitinol (TFN) and may be fabricated via sputter deposition on a micropatterned wafer.
US10945867B2	Coupling units for medical device delivery systems A stent coupler for use with a medical device delivery system is disclosed. A stent delivery system includes a core member having a distal segment and a coupler positioned about the core member distal segment. the coupler is rotatably coupled to the core member and includes a rigid plate having a first end surface, a second end surface, and a side surface extending between the first and second end surfaces, the side surface comprising one or more projections separated by recesses. The delivery system further includes a stent extending along the core member distal segment such that an inner surface of the stent is engaged by the one or more projections of the engagement member.
US10945863B2	Method for controlling an artificial orthotic or prosthetic knee joint A method for controlling an artificial orthotic or prosthetic knee joint, on which a lower-leg component is arranged and with which a resistance device is associated, the bending resistance of which resistance device is changed in dependence on sensor data that are determined by at least one sensor during the use of the orthotic or prosthetic knee joint, wherein a linear acceleration of the lower-leg component is determined, the determined linear acceleration is compared with at least one threshold value, and, if a threshold value of the linear acceleration of the lower-leg component is reached, the bending resistance is changed.

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