最新美国发明专利第2020-12-01期 - 专利汇|PatentHub专利检索|专利查询网|发明专利查询分析

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US10851440B2	Nanocrystalline high temperature machine parts Novel metallic systems and methods for their fabrication provide high temperature machine parts formed of a consolidated nano-crystalline metallic material. The material comprises a matrix formed of a solvent metal having a melting point greater than 1,250° C. with crystalline grains having diameters of no more than about 500 nm, and a plurality of dispersed metallic particles formed on the basis of a solute metal in the solvent metal matrix and having diameters of no more than about 200 nm. The particle density along the grain boundary of the matrix is as high as about 2 nm2 of grain boundary area per particle so as to substantially block grain boundary motion and rotation and limit creep at temperatures above 35% of the melting point of the consolidated nano-crystalline metallic material. The machine parts formed may include turbine blades, gears, hypersonics, radiation shielding, and other high temperature parts.
US10851435B2	Dual-hardness clad steel plate and production method thereof A dual-hardness clad steel plate. One surface of the steel plate is a high-hardness layer, the other surface of the steel plate is a low-hardness layer, and a combination of atoms is achieved between the high-hardness layer and the low-hardness layer by rolling bonding, wherein Mn13 steel is adopted for the low-hardness layer, and the Brinell hardness of the high-hardness layer is greater than 600. Further disclosed is a production method of the dual-hardness clad steel plate, comprising: 1) respectively preparing a high-hardness layer slab and a low-hardness layer slab; 2) assembling: preprocessing combined faces of the slabs, carrying out peripheral welded sealing on joint faces of the slabs, and carrying out vacuumizing treatment on a composite slab after welded sealing; 3) heating; 4) carrying out composite rolling; 5) cooling; and 6) carrying out thermal treatment, wherein the heating temperature is 1050-1100° C., the heating time is 2-3 min/mm×slab thickness, and water cooling is performed on the heated slab, and the water temperature is lower than 40° C. The steel plate has different hardness characteristics and good low-temperature toughness.
US10851430B2	Flash ironmaking system and method A flash ironmaking system and a flash ironmaking method are provided. The flash ironmaking system includes a pulverized coal gasifier; a drying pre-reduction kiln; and a flash furnace having a horizontal bottom in which a molten iron layer region, a slag layer region and a carburizing bed layer region are sequentially formed, a reduction tower, a concentrate nozzle, and a flue.
US10851428B2	Reagents and methods for analysis of HIV The present invention is based in part on the present inventors' appreciation that certain sequences within an HIV genome are more likely to successfully detect HIV across a breadth of HIV variants. The ability to detect and/or quantify the presence and/or load of HIV in a subject is important to, among other things, the diagnosis and treatment of infected individuals. The present invention is based, in part, on the discovery of oligonucleotide reagents that detectably amplify sequences from a greater breadth of HIV samples than certain prior reagents and/or that generate amplicons from HIV genomes from which certain prior reagents would not have generated amplicons. Oligonucleotide reagents as described herein provide unexpected benefits in the detection and/or quantification of the presence and/or load of HIV in a subject, and thereby in the diagnosis and treatment of HIV.
US10851425B2	Method for treating cancer This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
US10851422B2	Methods of determining an immune response score The present disclosure provides method for determining an immune response score (irScore), the method comprising: determining a number of differentially expressed genes that have are implicated in anti-tumor immune cell signaling/activation; determining a number of differentially expressed genes that are implicated in immunosuppression, wherein the irScore=X(low, medium, or high), wherein X is the number of differentially expressed genes that are implicated in anti-tumor immune cell signaling/activation, and wherein low refers to 1-4 differentially expressed genes that are implicated in immunosuppression, medium refers to 5-9 differentially expressed genes that are implicated in immunosuppression, and high refers to 10 or more differentially expressed genes that are implicated in immunosuppression.
US10851420B2	Editing profiling of PDE8A pre-mRNA: use as specific biomarker of ADARs activities in human tissues to diagnose and to predict and assess therapeutic efficacy and/or efficiency or potential drug side effects The present invention relates to the use of the editing profile of PDE8A pre-mRNA as a specific bio marker of ADARs activities in evolved primate, particularly in Human tissues. The present invention also relates to an in vitro method for predicting in Human an alteration of the mechanism of the ADARs catalysed pre-mRNA editing of target genes, by analysing the PDE8A pre-mRNA editing profile in a peripheral tissue sample containing cells expressing said PDE8A pre-mRNA, such as blood sample. The present invention is also directed to an in vitro method for the screening of potential therapeutic compound and to predict and assess therapeutic efficacy and/or efficiency or to diagnose potential severe brain or peripheral drug side effects implementing said PDE8A pre-mRNA editing profile as specific biomarker. The present invention is further directed to a method for determining the PDE8A pre-mRNA editing profile in Human, particularly by capillary electrophoresis single-strand conformation polymorphism (CE-SSCP) method after amplification by a nested PCR. Finally the invention relates to particular nucleic acid primers implemented in said nested PCR and kit comprising such sets of primers and human cells capable of expressing PDE8A and ADARs.
US10851417B2	High throughput sequencing The invention relates to a high throughput method for determining telomere length of mammalian chromosomal DNA; primers for use in said method; a kit comprising said primers; use of said method to diagnose or prognose or to determine the risk of developing a telomere shortening disease such as cancer, ageing, neurological disorders including Alzheimer's disease, Parkinson's disease and other dementias, brain infarction, heart disease, chronic HIV infection, chronic hepatitis, skin diseases, chronic inflammatory bowel disease including ulcerative colitis, anaemia, atherosclerosis, Barrett's oesophagus and cancers including pre-cancerous conditions, infertility, telomere syndromes including dyskeratosis congenita, aplastic anaemia, idiopathic pulmonary fibrosis, familial myelodysplastic syndrome-acute myeloid leukaemia, Hoyeraal-Hreiderasson syndrome, Revesz syndrome, Coats plus syndrome, bone marrow failure, and cryptogenic liver cirrhosis. Additionally, the invention also has application in assessing an individual's suitability to be a transplantation donor, for example a bone marrow donor.
US10851416B2	Predictive neurodiagnostic methods Disclosed are methods of predicting the risk of developing a neurological disorder in a mammalian subject and methods of use of this profile for providing neuroanalytical services for an end user. Also disclosed is a system comprising a processor and a memory having a neurodiagnostic algorithm and plurality of data sets, the processor being capable of reading the data sets, executing the neurodiagnostic algorithm, and deriving a risk profile therefrom.
US10851410B2	Nucleic acid sequencing using affinity reagents The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.
US10851406B2	Nicking and extension amplification reaction for the exponential amplification of nucleic acids The invention is in general directed to the rapid exponential amplification of short DNA or RNA sequences at a constant temperature.
US10851405B2	Concentrating a target molecule for sensing by a nanopore Methods and related products are disclosed that improve the probability of interaction between a target molecule and a nanopore by capturing the target molecule on a surface comprising the nanopore. The captured target molecule, the nanopore, or both, are able to move relative to each other along the surface. When the leader of the target molecule is in proximity with the nanopore, interaction of the target portion of the target molecule with the nanopore occurs, thereby permitting sensing of the target portion. Confining the target molecule and nanopore in this manner leads to significantly enhanced interaction with the nanopore.
US10851401B2	Broth microdilution method for evaluating and determining minimal inhibitory concentration of antibacterial polypeptides The present invention provides components, assays and methods for evaluating antibacterial effectiveness and determining minimal inhibitory concentration (MIC) of polypeptides, including lysin polypeptides, that kill bacteria. Modified broth microdilution components and methods are provided, including supplements to enable accurate MIC determination mimicking lysin polypeptide activity in human matrices including serum and blood.
US10851399B2	Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon are disclosed. Methods for identifying and determining the absolute cell count of microorganism types and strains, along with identifying the network relationships between active microorganisms and metadata, are also disclosed.
US10851398B2	Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence of an electron acceptor and has an activity toward maltose of 5% or lower; a polypeptide encoded by the nucleotide sequence of the polynucleotide; a recombinant vector carrying the polynucleotide; a transformed cell produced using the recombinant vector; a method for producing a polypeptide comprising culturing the transformed cell and collecting from the cultivated products a polypeptide that links to FAD to exert the glucose dehydration activity; a method for determination of glucose using the polypeptide; a reagent composition for determination of glucose; and a biosensor.
US10851395B2	Method of making lipids with improved cold flow properties Provided herein are methods of producing oils with reduced saturated fatty acids. The methods include culturing oil-producing microorganisms in a fermentation medium in the presence of one or more antifoaming agents under a controlled carbon consumption rate, wherein the culturing produces oils comprising fatty acids and wherein less than 35% of the fatty acids in the oil are saturated fatty acids.
US10851394B2	Decanedioic acid produced by microbial fermentation process and preparation method thereof The present invention provides a decanedioic acid produced by microbial fermentation process, in which the content of C10 aliphatic acid and C10 hydroxy aliphatic acid is maintained at a very low level. The present invention also provides a preparation method of the decanedioic acid and a polymer prepared by using the decanedioic acid as monomer. The decanedioic acid provided by the present invention is prepared by microbial fermentation process. The decanedioic acid product which is produced through the processes of microbial fermentation and separation has a higher purity, a higher thermal stability, and a lower impurity content. The decanedioic acid provided by the present invention could satisfy the requirements of high grade product of polyamide or polyester to produce polymer with excellent qualities. The preparation method of the decanedioic acid provided by the present invention which has many advantages of mild reaction conditions, environmental friendliness, high yield, and good product quality, may replace the chemical method to be used in industrial scale production of the decanedioic acid.
US10851390B2	Method for producing metal nanoparticles and metal sulfide nanoparticles using a recombinant microorganism The present invention relates to a method of producing metal nanoparticles and metal sulfide nanoparticles using a recombinant microorganism co-expressing metallothionein and phytochelatin synthase, which are heavy metal-adsorbing proteins, and to the use of metal nanoparticles and metal sulfide nanoparticles synthesized by the method. The present invention provides a method for synthesizing metal nanoparticles which have been difficult to synthesize by conventional biological methods. The present invention makes it possible to synthesize metal nanoparticles in an environmentally friendly and cost-effective manner, and also makes it possible to synthesize metal sulfide nanoparticles. In addition, even metal nanoparticles which could have been produced by conventional chemical or biological methods are produced in a significantly increased yield by use of the method of the present invention.
US10851386B2	Plants transformed to express a phosphite dehydrogenase enzyme capable of metabolizing phosphite to reduce competition from weeds System, including methods and compositions, for making and using transgenic plants capable of metabolizing phosphite to reduce competition from weeds. The plants may be transgenically modified to express a phosphite dehydrogenase enzyme capable of catalyzing oxidation of phosphite to phosphate and grown in the presence of sufficient phosphite to selectively promote growth of the plant relative to weeds near the plant.
US10851384B2	Tobacco having altered leaf properties and methods of making and using This disclosure provides tobacco plants having a mutation in PR50 and transgenic tobacco plants containing a PR50 RNAi, and methods of making and using such plants.
US10851379B2	Immunostimulatory plasmids The present invention relates to immunomodulator compositions and methods of use as well as methods of making. The immunomodulator compositions comprise immunostimulatory plasmids, or DNA sequence, capable of eliciting an immune response in a recipient subject. Further, the immunostimulatory plasmids, or DNA sequence, do not contain antibiotic resistance coding sequence to help reduce the potential of horizontal transfer of antibiotic resistance in a population.
US10851376B2	Long noncoding RNAs in pulmonary airway inflammation The subject invention provides methods, assays, and products for preventing and/or treating pulmonary diseases. The present invention provides methods for identifying inhibitors of lncRNAs, pharmaceutical compositions comprising such inhibitors, and method of using said inhibitors in preventing and/or treating pulmonary airway inflammation. The present invention also develop novel strategies to modulate the mucous response for preventing, intervening, diagnosing and treating pulmonary airway inflammation, asthma, chronic obstructive pulmonary diseases (COPD) and Chronic mucus hypersecretion (CMH) pathogenesis.
US10851375B2	RAAV-based compositions and methods for treating amyotrophic lateral sclerosis The invention relates to inhibitory nucleic acids and rAAV-based compositions, methods and kits useful for treating Amyotrophic Lateral Sclerosis.
US10851372B2	Exosome packaging of nucleic acids A method for preparing exosomes or exosome-like vesicles packaged with a nucleic acid of interest is provided. In certain embodiments, the method may comprise: introducing into an exosome-producing cell a nucleic acid construct comprising the nucleic acid sequence of interest incorporated in a pre-miR-451 structural mimic, and allowing the cell to produce exosomes. Nucleic acid constructs, compositions, and uses thereof are also provided.
US10851369B2	Frequency-based modulation of diverse species in a nucleic acid library A method of processing a collection of nucleic acid sequences is provided including connecting an adaptor to one or more or each nucleic acid sequence in the collection to create a processed nucleic acid template library, wherein the adaptor includes a first DNA sequence encoding a PAM sequence and at least a tracr mate.
US10851368B2	Device and process for automated extraction of nucleic acids A device and method are useful for automated extraction of nucleic acids. The device can include a body that can be immersed partly or completely in a reaction cavity, where the part immersed in the reaction cavity has a non-smooth surface. After lysis, an organic substance, preferably alcohols or ketones, can be mixed with a biological sample. This mixture can be brought into contact with a material with a non-smooth surface. Under these conditions, nucleic acids may be adsorbed on the surface of the material being used. Washing steps may be carried out. After drying, the adsorbed nucleic acid may be detached from the material by adding water or a buffer of low salt concentration, whereupon it can be used for downstream applications.
US10851365B2	Optimized microbial cells for production of melatonin and other compounds Described herein are recombinant microbial host cells comprising biosynthetic pathways and their use in producing oxidation products and downstream products, e.g., melatonin and related compounds, as well as enzyme variants, nucleic acids, vectors and methods useful for preparing and using such cells. In specific aspects, the present invention relates to monooxygenases, e.g., amino acid hydroxylases, with a modified cofactor-dependency, and to enzyme variants and microbial cells providing for an improved supply of cofactors.
US10851364B2	Method of controlling a polypeptide modification reaction The invention relates to a method of controlling a polypeptide modification reaction, in particular but not exclusively, a method of controlling the activation of human factor VII (FVII) to produce human factor VII(a) (FVII(a)). The invention also relates to polypeptides obtainable by the polypeptide modification reaction and to pharmaceutical compositions comprising said polypeptides.
US10851363B1	Multilayer nano-cell containing biomolecules Method for preparing botulinum neurotoxin and nanoparticle thereof are provided. The method includes fermenting bacteria Clostridium botulinum in a fermentation media free of animal-derived ingredients and contacting the fermentation media with an anion exchange media slurry and obtaining a supernatant including the botulinum neurotoxin by centrifugation. The method further includes dialyzing the supernatant and collecting a dialyzed solution including the botulinum neurotoxin, contacting the dialyzed solution with an anion exchange chromatography column, contacting an elute collected from the anion exchange chromatography column with a cation exchange chromatography column, and collecting an elute. The nanoparticle includes multi-layer including an innermost water phase core including biomolecules encapsulated by an oil phase layer, thereby forming a water-in-oil structure, water phase layers; oil phase layers; and an outmost cream layer. The water phase layers and the oil phase layers alternatively encapsulate the water-in-oil structure. The biomolecules include botulinum neurotoxin and/or hyaluronic acid.
US10851362B2	Intein-modified proteases, their production and industrial applications Methods for producing intein-modified proteases are provided. Expression cassettes and vectors for using to genetically engineer hosts are described. Hosts genetically engineered to express one or more intein-modified proteases using expression cassettes and vectors of the invention are also provided. Methods to produce a protease and regulate its activity are described.
US10851358B2	Engineered meganucleases specific for recognition sequences in the hepatitis B virus genome The present invention encompasses engineered meganucleases which recognize and cleave a recognition sequence within an open reading frame (ORF) of the genome of at least two genotypes of the Hepatitis B virus (HBV). The present invention also encompasses methods of using such engineered meganucleases in a pharmaceutical composition and in methods for treating or reducing the symptoms of a HBV infection, or treating hepatocellular carcinoma (HCC). Further, the invention encompasses pharmaceutical compositions comprising engineered meganuclease proteins, nucleic acids encoding engineered meganucleases, and the use of such compositions for treating HBV infections or HCC.
US10851355B2	IsPETase variants Disclosed are a method for preparing crystals of IsPETase protein, a method for screening an IsPETase protein activity regulator and IsPETase variants using a conformation of the protein crystal, a method for screening, IsPETase variants with increased PETase activity, and a method for decomposing PET using the variants. According to exemplary embodiments of the present invention, it is possible to determine a method for effectively preparing a crystal of the IsPETase protein and to obtain the resulting crystal thereof. Further, according to exemplary embodiments of the present invention, it is possible to identify a tertiary structure of the IsPETase from the crystal thereof and to prepare the variant with an increased PETase activity based on this structure. The IsPETase variant may be used effectively in the PET decomposition field.
US10851354B2	TRPV1 modulatory gene product that affects TRPV1-specific pain behavioral responses identified in a functional screen of an HSV-based cDNA library The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1α in neurons. The invention also provides HSV vectors for expressing PP1α within neurons and compositions comprising such vectors.
US10851352B2	Mycobacterium neoaurum-derived steroid C27-monooxygenase and application thereof The present invention discloses a Mycobacterium neoaurum-derived steroid C27-monooxygenase and an application thereof, which belong to the technical fields of genetic engineering and enzyme engineering. By the method of gene knockout and intensive expression, the present invention screens out three isoenzymes of a key enzyme SMO in the process of degrading sterol side chains from Mycobacterium neoaurum. The three isoenzymes are intensively expressed respectively in the Mycobacterium neoaurum for the high yield of androsta-1,4-diene-3,17-dione (ADD), the yield of ADD is increased remarkably, wherein the effect of SMO2 is most remarkable. By overexpressing SMO2, the final ADD yield is increased from 5.2 g·L−1 to 7.3 g·L−1. The present invention provides a helpful guidance for the industrialization of the microbial fermentation method for increasing the ADD yield.
US10851348B2	Proliferative primary human Sertoli cell cultures and their applications Technology for the isolation and propagation of primary human Sertoli cells from normal testes tissue, including cultures of proliferative primary human Sertoli cells for research and clinical applications, and a pharmaceutical composition for cell therapy, ex vivo gene therapy, and for the reduction of autoimmune, allograft, and xenograft immune reactions.
US10851345B2	Stem cells and decellularized tissue matrix from cord tissue Methods and products obtained from the method for isolating and culturing mixed populations of stem cells, making decellularized tissue matrix, making decellularized tissue matrix infused with said mixed populations of stem cells, and methods of stem cell therapy are provided.
US10851342B2	Method for producing pluripotent stem cells The present invention allows a TET1 protein to be more stably expressed in human pluripotent stem cells than in the past by, inter alia, substituting the second amino acid from the amino terminal of a TET1 protein with a different amino acid. Furthermore, upon differentiation of said pluripotent stem cells, it is possible to quickly eliminate the expression of, inter alia, NANOG, which is an inhibitor of differentiation and promote the expression of factors related to differentiation by introducing a variant TET1 protein to a pluripotent stem cell. The present invention provides a method for manufacturing pluripotent stem cells with increased differentiation potential, and a substance that is useful to said method.
US10851341B2	Methods and systems for harvesting cells Methods for using vibration to harvest cells grown in 3D culture are provided. The methods entail the application of force cells attached to a 3D matrix of sufficient amplitude, frequency, and duration to detach cells from the matrix and to flush the detached cells out of the matrix material. An apparatus for performing the methods of the invention as provided.
US10851333B2	Biomanufacturing system, method, and 3D bioprinting hardware in a reduced gravity environment A method, apparatus, and system are provided for the printing and maturation of living tissue in an Earth-referenced reduced gravity environment such as that found on a spacecraft or on other celestial bodies. The printing may be three-dimensional structures. The printed structures may be manufactured from low viscosity biomaterials.
US10851328B2	Ambient moisture-activated hard surface treatment powder Ambient moisture-activatable surface treatment powders containing persalt, positively charged phase transfer agent and alkaline pH buffering may be activatable without the addition of liquid. Some ambient moisture-activatable surface treatment powders are substantially free of bleach activators and/or chlorine. Methods of use of ambient moisture activatable powders include applying them to the surfaces to be treated.
US10851321B2	Removal of sulfur compounds from gas streams via precipitation Techniques for removing sulfur compounds from a sulfur-containing gas stream can include contacting the gas with an absorption solution comprising a metal cation capable of reacting with the sulfur compound to form a metal sulphide precipitate and/or a metal mercaptide precipitate. In addition, the treatment can include controlling a concentration of the precipitates below a threshold to maintain rheological properties; subjecting the precipitate-enriched solution to vitalization; subjecting the precipitate-enriched solution to regeneration including oxidation; and/or other features to enhance the sulfur removal operations.
US10851318B2	Descaling and anti fouling composition The disclosure relates to an anti fouling composition including a metallic component comprising of at least one alkali metal salt and a non-metallic component and method for preparation of anti fouling composition. The disclosure also relates to a process of reducing fouling in reactors or furnaces using said composition.
US10851314B2	Method to improve the efficiency of pipeline transportation of heavy oils Disulfide oil (DSO) compounds recovered as a by-product of the mercaptan oxidation of a hydrocarbon refinery feedstock and their oxidized derivatives, oxidized disulfide oils (ODSO) are effective as a diluent to lower the viscosity and thereby improve the pipeline transportation properties of heavy oils, and particularly of wellhead crude oil. The use of the DSO and/or ODSO compounds as diluents converts an otherwise extremely low value or waste oil product into a valuable commodity that has utility in improving the transportation properties of heavy oils, particularly in oil field pipeline applications.
US10851309B2	Conversion of waste plastic to propylene and cumene A process for producing propylene and cumene comprising converting plastics to hydrocarbon liquid and pyrolysis gas in pyrolyzer; feeding hydrocarbon liquid to hydroprocessor to yield hydrocarbon product and first gas stream; introducing hydrocarbon product to second separator to produce first C6 aromatics and refined product; feeding refined product to steam cracker to produce steam cracker product; introducing steam cracker product to third separator to produce second C6 aromatics, third propylene stream, second C2&C4 unsaturated stream, C1-4 saturated gas, and balance hydrocarbons product; introducing pyrolysis gas and/or first gas stream to first separator to produce first propylene stream, first C2&C4 unsaturated stream, and saturated gas stream; feeding first and/or second C2&C4 unsaturated stream to metathesis reactor to produce second propylene stream; feeding first and/or second C6 aromatics, and first, second, and/or third propylene stream to alkylation unit to produce cumene; and conveying balance hydrocarbons product to pyrolyzer and/or hydroprocessor.
US10851306B2	System and method for repairing a coke oven A system and method for repairing a coke oven having an oven chamber formed from ceramic bricks. A representative system includes a insulated enclosure insertable into the oven chamber and includes removable insulated panels that define an interior area for workers to work in. The insulated enclosure is movable between an expanded configuration and a compact configuration and moving the enclosure to the expanded configuration will decrease the distance between the insulated enclosure and the walls of the oven chamber. Removing the panels exposes the ceramic bricks and allows workers within the interior area to access and the bricks and repair the oven chamber while the oven chamber is still hot. A loading apparatus lifts and inserts the insulated enclosure into the oven chamber. The insulated enclosure can be coupled to additional insulated enclosures to form an elongated interior area.
US10851305B2	Combined heat, power, and biochar with ventilator The production of biochar generates syngas, VOCs, CO and other gasses that can adsorb to biochar and reduce the quality of the final product. A controller measures the operating parameters, such as temperature, pressure and oxygen level, and automatically controls a feedstock auger motor, blower(s) and other subsystems of a continuous combined heat, power and biochar carbonizer. The carbonizer pyrolyzes feedstock. A catalytic converter combusts unburned components in by-product gases and generates additional thermal energy. Thermal energy drives an engine, such as a Sterling, steam, or ORC engine, to generate electricity or operate a mechanical device. Remaining thermal energy is transferred using another medium, such as air or water, via a heat exchanger. The feedstock is purposefully incompletely combusted, to produce biochar that consists largely of carbon. The biochar may be used to augment soil for cultivation, filtration or for other purposes. Some embodiments condense water from the exhaust to provide potable water.
US10851302B2	Metal organic liquid crystal dyes A dye composition dissolvable within a liquid crystal host device (including: polymer dispersed liquid crystal, polymer network liquid crystal, polymer stabilized liquid crystal, liquid crystal displays and similar devices), comprising eutectic mixtures of dichroic metallomesogen molecules. The aforesaid metallomesogen molecules comprise chromophore groups synthesized by physical and chemical mixing methods.
US10851297B2	Composition, patterned film, and electronic device including the same A photosensitive composition including a quantum dot; a binder polymer including a carboxylic acid group; a photopolymerizable monomer including a carbon-carbon double bond; and a photoinitiator, a patterned film produced therefrom and a display device including the same. The quantum dot includes a seed including a first semiconductor nanocrystal, a quantum well including a second semiconductor nanocrystal, the quantum well surrounding the seed and a shell disposed on the quantum well, the shell including a third semiconductor nanocrystal and not including cadmium, the second semiconductor nanocrystal has a different composition from each of the first semiconductor nanocrystal and the third semiconductor nanocrystal, and an energy bandgap of the second semiconductor nanocrystal is smaller than an energy bandgap of the first semiconductor nanocrystal and an energy bandgap of the third semiconductor nanocrystal.
US10851295B2	Synthesis of luminescent 2D layered materials using an amine-met al complex and a slow sulfur-releasing precursor A method of synthesis of two-dimensional (2D) nanoparticles comprises combining a first nanoparticle precursor and a second nanoparticle precursor in one or more solvents to form a solution, followed by heating the solution to a first temperature for a first time period, then subsequently heating the solution to a second temperature for a second time period, wherein the second temperature is higher than the first temperature, to effect the conversion of the nanoparticle precursors into 2D nanoparticles. In one embodiment, the first nanoparticle precursor is a metal-amine complex and the second nanoparticle precursor is a slow-releasing chalcogen source.
US10851294B2	Fluoride phosphor composite, method of manufacturing fluoride phosphor composite, white light emitting apparatus, display apparatus, lighting device, and electronic device There is provided a fluoride phosphor composite including: fluoride phosphor core particles that may be expressed by the empirical formula AxMFy:Mn4+, wherein A may be at least one selected from the group consisting of Li, Na, K, Rb, and Cs, M may be at least one selected from the group consisting of Si, Ti, Zr, Hf, Ge, and Sn, the composition ratio (x) of A may satisfy 2≤x≤3, the composition ratio (y) of F may satisfy 4≤y≤7, each fluoride phosphor composite particle may be coated with a Mn-free fluoride coating. The Mn-free fluoride coating may have a thickness less than or equal to 35% of the size of each fluoride phosphor composite particle.
US10851289B2	Method for drilling a subterranean geological formation to form a well bore and circulating emulsified acid therein A method of acidizing a subterranean geological formation by injecting an emulsified acid into a wellbore, wherein the emulsified acid includes at least an aqueous phase comprising a hydrochloric acid solution, an oil phase comprising waste oil, and an emulsifier, and wherein the waste oil contains 45-75% by weight of aromatic compounds and preferably contains less than 0.5% by weight of non-hydrocarbon compounds. Various embodiments, and combinations of embodiments, of the emulsified acid and the method of acidizing are provided.
US10851287B2	Method of emulsifying an acid and acidizing a geological formation A method of acidizing a subterranean geological formation by injecting an emulsified acid into a wellbore, wherein the emulsified acid includes at least an aqueous phase comprising a hydrochloric acid solution, an oil phase comprising waste oil, and an emulsifier, and wherein the waste oil contains 45-75% by weight of aromatic compounds and preferably contains less than 0.5% by weight of non-hydrocarbon compounds. Various embodiments, and combinations of embodiments, of the emulsified acid and the method of acidizing are provided.
US10851282B2	Foaming agent composition and method for removing hydrocarbon liquids from subterranean wells A composition containing a quaternary organosilane foaming agent capable of foaming various liquids in order to remove the liquids from subterranean wells is described. For instance, the composition can be used to remove hydrocarbon condensate liquids from a gas well or an oil well. Of particular advantage, the composition can foam liquids containing substantial amounts of hydrocarbons.
US10851281B2	Development of anti-bit balling fluids Anti-bit balling drilling fluids and methods of making and using drilling fluids are provided. The anti-bit balling drilling fluid contains water, a clay-based component, and at least one of a surfactant having the formula: R—(OC2H4)x—OH, where R is a hydrocarbyl group having from 10 to 20 carbon atoms and x is an integer from 1 and 10, or a polyethylene glycol having the formula: H—(O—CH2—CH2)n—OH, where n is an integer from 1 to 50. Methods of making and using these drilling fluids are also provided.
US10851278B2	Stabilization and reduction of TCT of brines containing monovalent iodides A composition for use in a wellbore activity, the composition comprising a stabilized monovalent iodide brine, the stabilized monovalent iodide brine comprises a monovalent salt system, the monovalent salt system comprises a monovalent iodide; a primary iodide stabilizer, the primary iodide stabilizer operable to remove free iodine, prevent the formation of free iodine, and suppress TCT; and an aqueous fluid, where the stabilized monovalent iodide brine has a density greater than 10 lb/gal, where the stabilized monovalent iodide brine has a TCT of less than or equal to 70 deg F.
US10851271B2	Degradable flow medium for resin transfer molding processes A flow medium for assisting a resin to be transferred into a mold accommodating a layered structure of reinforced material is provided. The flow medium is configured such that when the resin is cured the flow medium becomes incorporated within a final composite component comprising the reinforced material embedded within the transferred and cured resin. A semifinished product comprising such a flow medium is provided and a method for producing a composite component by utilizing such a semifinished product is also provided.
US10851270B2	Adhesives comprising polyindane resins The present invention is generally related to various types of compositions that comprise a polyindane resin. In particular, the polyindane resins may be utilized in various polymer-based and elastomer-based formulations in order to enhance several properties and characteristics of those formulations. More specifically, adhesive formulations are provided that comprise at least one polyindane resin, which may be used to replace or enhance the functionality of existing hydrocarbon resins typically used in adhesive formulations. Compositions comprising at least one thermoplastic elastomer and at least one polyindane resin are also provided.
US10851266B2	Slurry composition for polishing and method for polishing semiconductor thin film with steps of a high aspect ratio The present invention relates to a slurry composition for polishing and a method for polishing a semiconductor thin film with steps of a high aspect ratio, and more particularly, by comprising polishing particles, a compound represented by Chemical Formula 1 below, and a compound represented by Chemical Formula 2 below, to make a slurry composition for polishing that has a high polishing speed in high stepped regions while simultaneously protecting low stepped regions to obtain a high degree of flatness without leaving remaining steps after the completion of polishing, and a method for polishing a semiconductor thin film with steps of a high aspect ratio. in Chemical Formula 1, n is an integer of 1 to 10, in Chemical Formula 2, R1 to R4 are independently C1-C10 alkyl groups, and m is an integer of 1 to 10.
US10851263B2	Water-based coating compositions and related products and processes Disclosed are improved water-based, polyamide-containing synthetic polymer coating compositions and related products and processes. The coating composition comprises 1 to 40% dry weight of polyamide powder, and can contain higher polyamide content than organic solvent-based coating products containing polyamide and polyurethane. The improved coating compositions are suitable for coating of metal substrates, such as aluminum sheets and panels. The improved coating compositions are also suitable for industrial coil coating processes, forming a thin and uniform coating layer when applied to a metal substrate, such as an aluminum sheet surface. Methods and processes related to production and uses of the coating compositions are described, as well as products produced by the processes using the coating compositions, such as roller shutters and architectural panels.
US10851262B2	Primer for digital printing The present invention is directed to primer coatings that enhance the adhesion of liquid digital printing inks and toners to the substrate. The coatings comprise one or more polyurethane dispersions and one or more acrylic emulsions. The coatings of the present invention improve resistance to mineral oils, such as those typically found in liquid digital printing inks and toners. The primer coatings of the invention also reduce blocking, so that a primer coated reel of substrate may be easily unrolled, even after having been stored in the rolled reel for an extended period of time.
US10851257B2	Silver and copper nanoparticle composites A silver nanoparticle composite or a copper nanoparticle composite is formed in which the silver nanoparticle composite has silver nanoparticles, and both (a) one or more polymers and ascorbic acid adsorbed on the silver nanoparticles, wherein the (a) one or more polymers are selected from one or more of cellulose acetate, cellulose acetate phthalate, cellulose acetate butyrate, cellulose acetate propionate, cellulose acetate trimellitate, hydroxypropylmethyl cellulose phthalate, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropylmethyl cellulose, and carboxymethyl cellulose. Copper nanoparticle composite are similarly formed in which both the (a) one or more polymers and ascorbic acid are adsorbed on the copper nanoparticles.
US10851256B2	Inkjet printing method and inkjet printing apparatus An inkjet printing method for printing an image by using a cyan ink, a magenta ink, and a blue ink, including the step of applying the blue ink to a region provided with both the cyan ink and the magenta ink.
US10851254B2	Photoinitiators and curable compositions A specific RAFT functionalized photoinitiator and its use in radiation curable compositions, inks and inkjet inks. The specific RAFT functionalized photoinitiator can be advantageously used to reduce migrateables and bad odour.
US10851251B2	Block copolymer ink formulation for 3D printing and method of making a 3D printed radiofrequency (RF) device An ink formulation for 3D printing comprises a triblock copolymer in a solvent, where the triblock copolymer includes end blocks comprising an aromatic or acrylate polymer and a midblock between the end blocks comprising an aliphatic polymer. The ink formulation exhibits a shear thinning threshold of about 0.02 rad/sec or less. A method of making a 3D printed radiofrequency (RF) device comprises extruding an ink formulation from a deposition nozzle moving relative to a substrate, where the ink formulation comprises a triblock copolymer in a solvent and the triblock copolymer includes end blocks comprising an aromatic or acrylate polymer and a midblock between the end blocks comprising an aliphatic polymer. One or more continuous filaments comprising the ink formulation are deposited in a predetermined pattern on the substrate, and the ink formulation is treated to remove or cure the solvent, thereby forming a printed RF device.
US10851250B2	UV-curable composition for coating or printing of a substrate and/or a substrate surface A UV-curable composition for coating or printing, in particular digital printing, of a substrate and/or a substrate surface, includes a monofunctional acrylate monomer/methacrylate monomer with a substituted or unsubstituted monocycloaliphatic hydrocarbon radical, at least one monofunctional acrylate monomer/methacrylate monomer with a substituted or unsubstituted heterocyclic, non-aromatic organic radical, at least one monofunctional acrylate monomer/methacrylate monomer with a substituted or unsubstituted bicyclic, non-aromatic hydrocarbon radical and at least one photoinitiator; and a method for coating and/or printing, in particular digital printing, of a substrate and/or a substrate surface, a kit and a substrate coated or printed, in particular digitally printed, with the UV-curable composition.
US10851247B2	High purity disorbate ester of triethylene glycol The present invention relates to a composition comprising triethylene glycol disorbate and triethylene glycol monosorbate, at a disorbate to monosorbate weight-to-weight ratio of from 19:1 to 99:1. The composition of the present invention is useful as a low VOC coalescent in coatings formulations.
US10851246B2	Electronic material filler, high-frequency substrate, and electronic material slurry A production method for an electronic material filler includes: a preparation step of preparing a silica particle material produced by a dry method; and a first surface treatment step of performing surface treatment on the silica particle material with a silane compound having a vinyl group, a phenyl group, a phenylamino group, an alkyl group having four or more carbon atoms, a methacryl group, or an epoxy group, to obtain a first surface treatment-processed particle material. After the silica particle material is produced by the dry method, the silica particle material is not brought into contact with liquid water, and has a particle diameter of 100 nm to 600 nm or a specific surface area of 5 m2/g to 35 m2/g.
US10851243B2	Room temperature curable organopolysiloxane composition for protecting electric/electronic parts A room temperature curable organopolysiloxane composition for protecting electric/electronic parts is disclosed. The composition comprises: (A) an organopolysiloxane having a viscosity at 25° C. of 20 to 1,000,000 mPa·s and having at least two silicon atom-bonded hydroxyl groups or silicon atom-bonded alkoxy groups in a molecule; (B) an alkoxysilane represented by the following general formula or a partial hydrolysis condensation product thereof: R1aSi(OR2)(4-a) wherein R1 is a monovalent hydrocarbon group having a carbon number of 1 to 12, R2 is an alkyl group having a carbon number of 1 to 3, and subscript “a” is an integer of 0 to 2; (C) a mercaptobenzothiazole based compound; (D) zinc oxide powder and/or zinc carbonate powder; and (E) a catalyst for condensation reactions. The composition and/or a cured product thereof can protect electric/electronic parts from corrosive gases such as hydrogen sulfide gas and sulfuric acid contained in the atmosphere.
US10851237B2	Block copolymer, multilayered structure, solid polymer membrane, fuel cell, method for producing multilayered structure, and method for producing multilayered structure including inorganic nanoparticles The problem addressed by the present invention is to provide a block copolymer that can be used in a neutral solvent atmosphere and can produce a solid polymer membrane including nanoparticles.The problem is solved by a block copolymer represented by formula (1) below. wherein in the formula, R1 represents a C1-20 linear, branched, or cyclic alkyl group, C6-20 aryl group, or C7-20 aralkyl group; R2 represents a group having a functional group having an acid dissociation constant pKa of from 0.5 to 7; R3, R4, and R5 each show H or a C1-20 linear, branched, or cyclic alkyl group; R6, R7, and R8 each represent a hydrogen, hydroxyl group, nitro group, carboxy group, or carbonyl group; X represents an amide or ester, but may not be included; Y represents an amide or ester, but may not be included; p represents an integer of 1-10, but may not be included; n represents an integer of 3-1000; m represents an integer of 3-1000; and t represents an integer of 3-1000, but n may not be included; the arrangement of n, m, and t is arbitrary, but n and m are adjacent when n is included.
US10851235B2	Scratch-resistant PMMA and polycarbonate siloxane copolymer compositions Thermoplastic compositions include: from about 62 wt % to about 99 wt % poly(methyl methacrylate) (PMMA) or copolymers thereof; and from about 1 wt % to about 38 wt % of a poly(carbonate-siloxane) copolymer having a siloxane content of from about 25 wt % to about 45 wt %. The compositions are scratch resistant. Scratch resistance may be determined as comprising a scratch depth of less than 20 micron (μm) as measured in accordance with the Erichsen scratch hardness test at a force of 4 Newton (N). Articles including the thermoplastic composition are also described.
US10851233B2	Acrylic composition Provided is a polymer composition comprising an acrylic resin and a compound (I) wherein R1, R2, R3, and R4 is each independently hydrogen or an organic group having 1 or more carbon atoms, and n is from 1 to 20.
US10851231B2	Polymer composition with filler, its method of preparation and use The present invention relates to a polymeric processing aid its composition and its process of preparation and its use. In particular, the present invention relates to a polymeric processing aid and its use for filled halogen containing thermoplastic polymers. More particularly, the present invention relates to a filled halogenated containing polymer composition with a polymeric processing aid, its composition and its process of preparation.
US10851223B2	Use of a cyclodextrin polycondensate or a composition comprising such a polycondensate, as a capturing agent The use of a cyclodextrin polycondensate or a composition comprising at least one cyclodextrin polycondensate, as an agent for capturing at least one substance chosen from a metal element and an organic molecule having an octanol/water partition coefficient, referred to as Log Kow, greater than or equal to 2, the cyclodextrin polycondensate being obtained by reacting the following compounds (A) to (C): (A) at least one cyclodextrin, (B) at least one linear, branched or cyclic polycarboxylic acid, that is saturated, unsaturated or aromatic, and (C) at least one ethylene vinyl alcohol copolymer (EVOH).
US10851220B2	Plasticizer composition and resin composition including the same A plasticizer composition and a resin composition including the same. The plasticizer composition includes a terephthalate-based material including a mixture of dibutyl terephthalate, butyl(2-ethylhexyl) terephthalate and di(2-ethylhexyl) terephthalate; and a triethylene glycol diester-based material including a mixture of triethylene glycol bis(2-ethylhexanoate), (2-ethylhexanoyloxy) triethylene glycol benzoate and triethylene glycol dibenzoate. A material prepared from the resin composition has excellent mechanical properties, such as tensile strength, elongation rate, modulus, transmittance, transparency and plasticization efficiency.
US10851216B2	Black film A black film containing a thermoplastic resin (A) that contains two or more types of dyes other than black, where a thickness T is 45 to 550 μm, a total concentration C of the dyes other than black is 0.4 to 5 mass % with respect to the thermoplastic resin (A), the total concentration C of the dyes and the thickness T satisfy the following expression (1): C×T≥210 (1) where in a Lab* color system measurement compliant with JIS Z 8781-4, L* (lightness) is no more than 10, an absolute value of a* is no more than 2.0, and an absolute value of b* is no more than 2.0, and a total light transmittance obtained after the black film is stretched twofold in one axial direction at a temperature higher than a glass transition temperature by 20° C. is no more than 3.0%.
US10851213B2	Method for optimizing a hegman rating of a diluted emulsion, a diluted emulsion produced thereby, and a coating made A method for optimizing a Hegman rating of a diluted emulsion including adjusting the shear work in the dilution mixer, wherein the adjusting the shear work may comprise raising or lowering the shear work; adjusting the temperature of the concentrated and/or diluted emulsion; if not earlier added, adding a basic aqueous solution and/or dispersing agent; adding one or more other additives; and/or adjusting the amount of any additive, basic solution or surfactant solution is provided. Also provided are diluted emulsions produced thereby and coatings made from the diluted emulsions.
US10851212B2	Polymeric BODIPY dyes and methods for using the same Polymeric BODIPY dyes including light harvesting BODIPY unit-comprising multichromophores are provided. In some embodiments, the dyes are polymeric tandem dyes that include a light harvesting BODIPY unit-comprising multichromophore and an acceptor chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. The polymeric tandem dyes may be covalently linked to a specific binding member. Also provided are methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule using compositions including the polymeric tandem dyes. Kits and systems for practicing the subject methods are also provided.
US10851211B1	Formulations for 3D printing of isocyanate-modified polysilazanes or polycarbosilanes Some variations provide a preceramic resin precursor formulation comprising: first molecules comprising at least one Si—N bond and/or at least one Si—C bond; and second molecules of the formula R4—N═C═O or R4—N═C═S, wherein R4 is a UV-active functional group. In some embodiments, R4 is selected from acrylate, methacrylate, vinyl ether, epoxide, oxetane, thiol, or a combination thereof. The first and second molecules are reacted with an isocyanate or isothiocyanate to form third molecules, providing a preceramic radiation-curable resin composition. The resin composition contains at least one Si—N bond and/or at least one Si—C bond in the main chain of the third molecules. Side chains of the third molecules may be selected from hydrogen, unsubstituted or substituted hydrocarbon groups, halides, esters, amines, hydroxyl, or cyano. The resin composition may be 3D printed and thermally treated to generate a ceramic material.
US10851208B2	Method for producing SiOH-functional polysiloxanes High hydroxyl-content organopolysiloxanes of low molecular weight are prepared in a continuous process by metering in alkoxysilanes and chlorosilanes in a weight proportion of 60:40 or more to a reaction mixture containing water and non-polar solvent, and continuously removing an organic phase containing organopolysiloxanes from the reaction mixture.
US10851207B2	Aromatic polysulfone, prepreg, and method for producing prepreg A thermoplastic aromatic polysulfone is obtained by polymerizing a dihalogeno compound (A) and a dihydric phenol (B). The ratio (Mw/Mn) between a number average molecular weight (Mn) and a weight average molecular weight (Mw) is at least 1.80 and less than 1.90, and the number average molecular weight (Mn) is at least 6,000 and less than 14,000. In (A) and (B), each of X and X′ independently represents a halogen atom; each of R1, R2, R3 and R4 independently represents an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; each of n1, n2, n3 and n4 independently represents an integer of 0 to 4; and when n1, n2, n3 or n4 is an integer of 2 to 4, a plurality of R1, R2, R3 or R4 groups may be the same or different from each other.
US10851205B2	Purification of poly ether ketone ketone by centrifugal filtration A method for the manufacture of polyether ketone ketone (PEKK), including the steps of: reacting 1,4-bis(4-phenoxybenzoylbenzene) and/or diphenylether with at least one difunctional aromatic acyl chloride, in a reaction solvent and in presence of a Lewis acid, to obtain a product mixture including a PEKK-Lewis acid complex; contacting the obtained product mixture with a protic solvent, so as to form a dispersion that includes a liquid phase including Lewis acid and a second phase, e.g., a solid phase, including PEKK; and separating the second phase from the liquid phase by centrifugal filtration, so as to recover a crude PEKK and a effluent containing Lewis acid, wherein step (iii) includes a step of centrifugal filtration.
US10851204B2	Modified fluorooxymethylene group-containing perfluoropolyether The present invention provides compound of formulae (A1), (A2), (B1), (B2), (C1) and (C2) which can form a layer having water-repellency, oil-repellency and antifouling property as well as high friction durability: wherein each symbols are as defined in the specification.
US10851202B2	Urethane-compatible polyester adhesion promoters The present invention concerns polyester resins of General Formula I (HO—[R1R2C(CH2—)]a[—OCOCxHyCO2—]b[—CpHzO—]c—H) or General Formula II (HO—[R1R2C(CH2—)2]a[—OCOCxHyCO2—]b[—CH2CR3(CO2H)CH2O]d—H), wherein R1, R2, a, b, c, d, x, y, p, and z are as defined herein, for use in inks and coating compositions. The polyester resins of the present invention are particularly, but not exclusively, suitable to enhance the adhesion between a printing ink or coating composition and a substrate, especially a plastic substrate, to which it is applied. The polyester adhesion promoters of the invention are compatible with urethane-based inks and coating compositions.
US10851201B2	Curing agent for thermosetting epoxy resins, and a process for the preparation of insulation systems for electrical engineering The invention relates to a curing agent for thermosetting epoxy resins comprising (a) at least one aromatic amine containing at least two amino groups, and (b) at least one clathrate compound obtained by reacting a tetrakisphenol of the formula (1), or a 9,9-Bis(4-hydroxyphenyl)fluorene of formula (2), as the host molecule, and an imidazole or an imidazolium derivative as the guest molecule, wherein the substituents are as defined in the description, and n is the number 0, 1, 2 or 3, which can advantageously be used for the curing of epoxy resins. In addition, the invention also relates to a process for the preparation of a cured article, a process for the preparation of insulation systems for electrical engineering and a cured article obtained by the processes.
US10851195B2	Polyurethane (meth)acrylate oligomers and curable compositions comprising said oligomers A polyurethane (meth)acrylate oligomer, having a tri-block symmetric structure BAB, comprises a polyether central block A linked by two urethane bonds to respectively two terminal hydrophobic blocs B based on hydrophobic polyester oligomers having a terminal (meth)acryloyloxy alkylene group. A curable composition (1k) comprises the oligomer and may be used for soft touch coatings in electronics, consumer goods and vehicle manufacture, as the resulting cured soft touch coating.
US10851193B2	Flow modifiers for coating compositions This invention relates to copolymers AB having moieties derived from vinyl-terminated polysiloxanes A with more than one vinyl group bound to the polysiloxane, and moieties derived from two or more alkyl esters B of an olefinically unsaturated carboxylic acid, wherein at least two different alkyl esters B1 and B2 are used; the alkyl group of the first alkyl ester B1 of an olefinically unsaturated carboxylic acid has from one to five carbon atoms, the alkyl group of the second alkyl ester B2 of an olefinically unsaturated carboxylic acid has from six to thirty carbon atoms, and moieties derived from at least one hydroxyalkyl ester B3 of an olefinically unsaturated carboxylic acid, the ester B3 having at least one hydroxyl group in the alkyl group, and from two to six carbon atoms in the alkyl group, to a process for their preparation, and to a method of use thereof as flow modifiers in coating compositions.
US10851192B2	Dihydropyridazine-based antioxidants and uses thereof Dihydropyridazines compounds having antioxidant properties and uses thereof are described herein. These compounds can function as antioxidants that prevent oxidation of materials, including polymers, and as free radical inhibitors to stabilize reactive chemicals, such as monomers against free radical reactions. The dihydropyridazines can be added as small molecule additives or they can be incorporated into molecules bearing dienophilic C═C double bonds through a Carboni Lindsey reaction, which can reduce environmental and health exposure to antioxidants in plastics and allow for a greater quantity of the antioxidants to be used.
US10851191B2	Process for preparing propylene polymer compositions The present invention relates to an olefin polymerization process, wherein propylene and a C4 to C10 a-olefin, preferably 1-butene and optionally ethylene are reacted in the presence of a Ziegler-Natta catalyst so as to obtain a polypropylene, wherein the polypropylene comprises C4 to C10 a-olefin, preferably 1-butene-derived comonomer units in an amount of from 0.5 wt % to 15 wt % and ethylene-derived comonomer units in an amount of 0 wt % to 3 wt %, and wherein the Ziegler-Natta catalyst comprises i) an external donor of the formula (I): (R3)z(R2O)ySi(R1)x and ii) a solid Ziegler-Natta catalyst component being free of external carrier material.
US10851190B2	Mono- and multi-layer films and articles made therefrom Mono- and multi-layer films comprising a polyethylene composition which comprises the reaction product of ethylene and optionally one or more alpha olefin comonomers in the presence of a catalyst composition comprising a multi-metallic procatalyst via a solution polymerization process in at least one reactor; wherein said polyethylene composition is characterized by one or more of the following properties: a melt index, I2, measured according to ASTM D 1238 (2.16 kg @ 190° C.), from 0.1 to 5 g/10 min; density, measured according to ASTM D-792, from 0.910 to 0.935 g/cc; melt flow ratio, I10/I2, wherein I10 is measured according to ASTM D1238 (10 kg @ 190° C.), from 6 to 7.4; and molecular weight distribution, (Mw/Mn) from 2.5 to 3.5 are provided. Also provided are articles made from the mono- and/or multi-layer films.
US10851182B2	Hydrolyzed starch compositions and their use in food applications Provided herein are common starch-based and waxy starch-based hydrolyzed starches. The hydrolyzed starches described herein demonstrate desirable properties over existing hydrolyzed starches for food applications, including but not limited to, dairy, ready-to-eat cereal coatings, clean-label confectionary products, nutritional and cereal bars, crumb chocolate, infant and/or elderly nutrition.
US10851181B2	Polymer and method for producing polymer membrane In order to obtain a crosslinked cellulose without derivatization, a polymer according to an embodiment of the present disclosure is a polymer having a structure in which cellulose substantially represented by the following formula (c1) is crosslinked with a polyfunctional epoxy compound: wherein in the formula (c1), n represents an integer of 2 or more.
US10851179B2	Polysaccharide derivatives and cross-metathesis processes for preparing them Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose ω-carboxyesters via olefin cross-metathesis with acrylates is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate acrylate partners appear to follow Grubbs rules as summarized herein. Additionally, a method of hydrogenation of the cross-metathesized product is described. The compounds and methods may be useful for waterborne coating applications, adhesives, lubricants, or any product in need of dispersion in an aqueous media.
US10851177B2	Method for inhibiting intracellular activated RAS using intact immunoglobulin-type antibody having cytosol-penetrating ability and use thereof The present disclosure relates to a method for inhibiting intracellular activated (GTP-bound) RAS using an intact immunoglobulin-type antibody having the ability to penetrate the cytosol, and to the use thereof. The disclosure further relates to a heavy-chain variable region (VH) which induces an intact immunoglobulin-type antibody to penetrate the cytosol and bind to activated RAS in the cytosol, and to an antibody comprising the same. The disclosure correspondingly provides a method for inhibiting the growth of cancer or tumor cells using the antibody, and a method for treating cancer or tumor.
US10851174B2	Core fucosylated glycopeptides and glycoproteins: chemoenzymatic synthesis and uses thereof A chemoenzymatic method for the preparation of a core-fucoslyated glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of a fucosylated GlcNAc-protein and fucosylated GlcNAc-peptide; and (b) reacting the acceptor with a donor substrate including an activated oligosaccharide moiety, in the presence of an endoglycosidase (ENGase) selected from Endo;F1, Endo-F2, Endo-F3, Endo-D and related glycosynthase mutants to transfer the oligosaccharide moiety to the acceptor and yield the structure defined core-fucosylated glycoprotein or glycopeptide. The donor substrate includes, in a specific implementation, a synthetic oligosaccharide oxazoline. A related method of fucosylated glycoprotein or fucosylated glycopeptide remodeling with a predetermined natural N-glycan or a tailor-made oligosaccharide moiety, and a method of remodeling an antibody to include a predetermined sugar chain to replace a heterogeneous sugar chain, are also described.
US10851172B2	Humanized antibodies against CD269 (BCMA) A method of treating a medical disorder associated with the presence of pathogenic B cells expressing B cell maturation antigen (BCMA), the method comprising administering to a subject an isolated antibody or antibody fragment comprising specific VH and VL domain complementary determining region (CDR) sequences, wherein the antibody or fragment thereof specifically binds an epitope of the extracellular domain of CD269 (BCMA).
US10851169B2	Conjugates of IL13Rα2 binding agents and use thereof in cancer treatment Provided are specific binding molecules, or fragments thereof, that bind to an epitope of IL13Rα2, a receptor polypeptide preferentially found on the surface of cancer cells rather than healthy cells. Exemplary specific binding molecules are bispecific binding molecules that comprise a fragment of an IL13Rα2 binding molecule and a peptide providing a second function providing a signaling function of the signaling domain of a T cell signaling protein, a peptide modulator of T cell activation, or an enzymatic component of a labeling system. Also provided are polynucleotides encoding such a specific binding molecule (e.g., bispecific binding molecule), vectors, host cells, pharmaceutical compositions and methods of preventing, treating or ameliorating a symptom associated with a cancer disease such as a solid tumor disease (e.g., glioblastoma multiforme).
US10851165B2	Antibody molecules to PD-L1 and methods of treating cancer Antibody molecules that specifically bind to PD-L1 are disclosed. Combination therapies comprising the anti-PD-L1 antibody molecules are also disclosed. The anti-PD-L1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.
US10851159B2	Antibodies that bind to human anti-Müllerian hormone (AMH) and their uses The present invention relates to antibodies or fragments thereof that bind to human Anti-Müllerian hormone (AMH) comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO: 1, and/or a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO: 2, and/or a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 3; and/or comprising a light chain CDR1 comprising the amino acid sequence of SEQ ID NO: 4, and/or a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 5 and/or a light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 6. The present invention further relates to antibodys or fragments thereof that bind to human Anti-Müllerian hormone (AMH) for use in a method for treating cancer in a subject.
US10851158B2	Biomarkers related to interleukin-33 (IL-33)-mediated diseases and uses thereof The present invention relates to the identification of certain biomarkers for use in identifying patients who have, or are likely to develop an IL-33 mediated disease or disorder and who are more likely to respond to therapy with an IL-33 antagonist. The invention also relates to methods of treatment of an IL-33-mediated disease or disorder in a patient by administering an IL-33 antagonist to the patient in need thereof and monitoring the effectiveness of therapy using the biomarkers described herein. Also provided are methods for decreasing the level of at least one biomarker in a subject suffering from an IL-33-mediated disease or disorder, and methods for treating such diseases or disorders according to the expression levels of one or more biomarkers. The methods of the present invention comprise administering to a subject in need thereof a pharmaceutical composition comprising an interleukin-33 antagonist.
US10851153B2	Compositions and methods for the treatment of carboxyhemoglobinemia Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed therapy involves the use of modified human globins, particularly neuroglobins modified at residue 64 and cytoglobins modified at residue 81, which bind carbon monoxide with extremely high affinity. The monomeric mutant globins are infused into blood, where they rapidly and irreversibly sequester carbon monoxide, and thus limit toxic effects of carbon monoxide on cellular respiration and oxygen transport and utilization.
US10851151B2	Epitope for switching to TH17 cell and use thereof The present invention relates to a novel epitope to convert T cell to type 17 helper T (TH17) cell. Specifically, the present invention relates to an epitope constituting the 41st to 50th amino acids (SEQ ID No.2) of extracellular domain (ECD) of activation-inducible tumor necrosis factor receptor (AITR), an antibody recognizing the epitope, a polynucleotide encoding the epitope, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide encoding the epitope or antibody, a transformant introduced with the vector, a composition comprising the antibody for converting T cell to TH17 cell and a method of conversion for the same, a pharmaceutical composition comprising the antibody for preventing or treating infectious disease, a method for treating infectious disease using the antibody, a composition comprising the antibody for enhancing immunity, and a method for enhancing immunity using the antibody.
US10851150B2	Carbohydrate content of CTLA4 molecules The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
US10851149B2	Treatment of cancer using GFR α-4 chimeric antigen receptor The present invention relates to compositions and methods for treating diseases, disorders or conditions associated with the expression of the Glycosyl-phosphatidylinositol (GPI)-linked GDNF family α-receptor 4 (GFRα4).
US10851142B2	Heterodimeric vascular endothelial growth factor and use thereof A fusion protein, comprising: (i) a first vascular endothelial growth factor (VEGF) isoform, and (ii) a second VEGF isoform, and (iii) a dimerization domain between the first isoform and the second isoform, wherein the first isoform and the second isoform are selected from VEGF121 and VEGF165.
US10851141B2	Mutant beetle luciferase, gene, recombinant vector, transformant, and method for preparing mutant beetle luciferase The present invention provides a mutant beetle luciferase and the like, having mutation in which the amino acid corresponding to valine at position 288 in the amino acid sequence of wild-type Photinus pyralis luciferase is isoleucine, leucine or phenylalanine, mutation in which the amino acid corresponding to leucine at position 376 in the aforementioned sequence is proline, mutation in which the amino acid corresponding to glutamic acid at position 455 in the aforementioned sequence is valine, alanine, serine, leucine, isoleucine or phenylalanine, or mutation in which the amino acid corresponding to glutamic acid at position 488 in the aforementioned sequence is valine, alanine, serine, leucine, isoleucine or phenylalanine, in the amino acid sequence encoding a wild-type beetle luciferase, and characterized in that a luminescence intensity due to a luciferin-luciferase luminescence reaction in a 0.9% by mass NaCl solution is 50% or more of that in a NaCl-free solution.
US10851140B2	Method for increasing ETEC CS6 antigen presentation on cell surface and products obtainable thereof A method for increase the presentation of ETEC CS6 antigen on a cell surface, comprising the step of contacting cells expressing said antigen with an aqueous solution comprising 0.6-2.2 percent phenol by weight, such that the presentation of said antigen is increased by at least 100%. A method for the manufacture of a killed whole cell vaccine for immunization against CS6-expressing ETEC. Cells and vaccines obtainable by the above methods.
US10851134B2	Method for preparing cyclopeptide A method for preparing a cyclopeptide, which includes the following steps: (A) providing compounds represented by the following formulas (II-1) or (II′-1) and (II-2); (B) performing a reaction between the compounds of formulas (II-1) or (II′-1) and (II-2), to obtain a compound represented by the following formula (II-3) and (II′-3), respectively; (C) performing a reaction between the compound of formula (II-3) or (II′-3) and a compound represented by the following formula (II-4) or (II′-4), respectively, is performed, to obtain a compound represented by the following formula (II-5), and (II′-5), respectively; (D) performing a cyclization reaction of the compound of formula (II-5) or (II′-5) with a catalyst of formula (III), to obtain a compound represented by the following formula (I) or (I′), respectively. The formulas (I), (I′), (II-1) to (II-5), (II′-1) to (II′-5) and (III) are shown in the specification.
US10851125B2	Crystalline forms of ethyl ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl(-L-alaninate The present invention relates to novel forms of ethyl ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate, pharmaceutical formulations, and therapeutic uses thereof in treating viral infections (e.g., an HIV infection).
US10851121B2	Scalable polypropionate lactone stereotetrads The present technology is directed to polypropionate lactone stereotetrads of Formula (I) (or a pharmaceutically acceptable salt and/or solvate thereof) which are significant intermediates for multiple synthetic applications.
US10851120B2	Diphenylmethane protective agent An object of the present invention is to develop a protecting group, which can prevent solidification or insolubilization of a compound by protecting a functional group to achieve easy separation and purification after a reaction.A diphenylmethane compound represented by general formula (1): wherein Y represents —OR19 (wherein R19 represents a hydrogen atom or an active ester-type protecting group), —NHR20 (wherein R20 represents, for example, a hydrogen atom, a C1-6 linear or branched alkyl group, or an aralkyl group, at least one of R1 to R10 represents a group represented by formula (2): —O—O—R11—X-A (2) and the others each independently represent a hydrogen atom, a halogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group; R11 represents a C1-16 linear or branched alkylene group; X represents O or CONR21 (wherein R21 represents a hydrogen atom, or a C1-4 alkyl group; and A represents, for example, a group represented by formula (3).
US10851116B2	Bicyclic amines as novel JAK kinase inhibitors The present invention relates to a compound according to formula I wherein R1 is alkyl; n is 1 or 2; R2 is selected from the group consisting of hydrogen, cyano, —SO2Ra, —SO2NRbRc, —C(O)Rb, phenyl and 5- and 6-membered heteroaryl or pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention relates further to pharmaceutical compositions comprising said compounds, and to methods of treating proliferative or inflammatory skin disorders with said compounds.
US10851115B2	Heterocyclic compounds as RSV inhibitors The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
US10851113B2	Heterocyclic inhibitors of monocarboxylate transporters The invention provides heterocyclic compounds of formula A, B, and C as described herein that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.
US10851112B2	Anti-HCMV virus compound Disclosed are a class of fused cyclic compounds against the HCMV virus, and use thereof in the preparation of a drugs for treating diseases associated with the HCMV virus. In particular, disclosed is the compound shown in formula (II) and pharmaceutically acceptable salts thereof.
US10851108B2	Substituted bicyclic heterocyclic compounds Disclosed are compounds of Formula (I), or a salt thereof, wherein: X is CR4 or N; Y is CR4 or N, provided that Y is N only if X is N; R1 is Formulae (A) or (B); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, R3, R4, L1, R1a, R1b, R1c, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
US10851106B2	Substituted benzo[4,5]imidazo[1,2-F]phenanthridines, dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzofurophenanthridines and dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzo[4,5]thienophenanthridines as thermally assisted delayed fluorescent materials Thermally assisted delayed fluorescent materials with triad-type materials for use in full color displays and lighting applications with the following generic structures are provided:
US10851104B2	Valbenazine salts and polymorphs thereof Provided herein are salts of (S)-2-amino-3-methyl-butyric acid (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]-isoquinolin-2-yl ester in amorphous and crystalline forms, and processes of preparation, and pharmaceutical compositions thereof. Also provided are methods of their use for treating, preventing, or ameliorating one or more symptoms of neurological disorders and diseases including hyperkinetic movement disorders or diseases.
US10851103B2	Valbenazine salts and polymorphs thereof Provided herein are salts of (S)-2-amino-3-methyl-butyric acid (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl ester in amorphous and crystalline forms, and processes of preparation, and pharmaceutical compositions thereof. Also provided are methods of their use for treating, preventing, or ameliorating one or more symptoms of neurological disorders and diseases including hyperkinetic movement disorders or diseases.
US10851099B2	Dipeptide piperidine derivatives The disclosure relates to pharmaceutical compositions, to methods of preparing such compositions, and to methods for using such compositions for treating or preventing a disease or condition associated with arginase activity.
US10851098B2	Azole amides and amines as alpha v integrin inhibitors The present invention provides compounds of Formula (I): (Formula (I)), or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are inhibitors to αv-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of αv-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
US10851097B2	4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors There are provided compounds of formula (I), wherein X, Ak, s, L, Q, R1 and R2 have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of the JAK family) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
US10851095B2	Methods and agents for treating disease The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving elevated levels of aldosterone or abnormal or excessive fibrosis, such as kidney disease and hypertension.
US10851088B2	Polymorphs and solid forms of a pyrimidinylamino-pyrazole compound, and methods of production The present disclosure relates to crystalline polymorph and amorphous forms of 2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile or solvates, tautomers, and pharmaceutically acceptable salts or cocrystals thereof, and processes for their preparation.
US10851083B2	Benzoimidazoles as prolyl hydroxylase inhibitors The present invention is directed to benzoimidazole compounds of the formula: and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions modulated by prolyl hydroxylase activity.
US10851073B2	Protein tyrosine phosphatase inhibitors and methods of use thereof Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases, disorders and conditions favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.
US10851070B2	Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives The present invention relates to processes and intermediates useful in the preparation of biologically active molecules, especially in the synthesis of Respiratory Syncytial Virus (RSV) inhibitors. The present invention also relates to processes and intermediates for the preparation of compounds of Formula (I-0) and Formula (I):
US10851061B2	Crystalline solid forms of N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.
US10851057B2	1,4-substituted piperidine derivatives Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.
US10851051B2	Compositions and methods for treating multiple myeloma In one aspect, the present invention provides a method of inhibiting proliferation of a multiple myeloma cell, the method comprising contacting the cell with BRD9647, thereby inhibiting proliferation of the cell. In another aspect, the present invention provides a method of treating multiple myeloma in a pre-selected subject, the method comprising administering an effective amount of BRD9647 to the subject, wherein the subject is pre-selected by detecting a mutation in an AZIN1 polynucleotide or polypeptide relative to a reference in a biological sample obtained from the subject. In another aspect, the present invention provides a method of modulating benzoylation of an agent in a cell, the method comprising contacting the cell with BRD9647, thereby modulating benzoylation of an agent in the cell.
US10851048B2	Process for preparing an isocyanate by partly adiabatically operated phosgenation of the corresponding amine A process for preparing an isocyanate by reacting a primary amine with phosgene. The process includes providing an amine solution and adjusting its temperature in a heat exchanger, providing a phosgene solution and adjusting its temperature in a heat exchanger, mixing the amine solution with the phosgene solution, further conversion in an adiabatically operated reaction zone and the removing of the gas phase formed as a result of the chemical reaction in a separation zone, expanding the remaining liquid phase, further conversion of the liquid phase remaining after expansion in an indirectly heated reaction zone, and isolating the isocyanate from the obtained reaction solution. The temperature in the reaction zone and the temperature in the separation zone is adjusted by fixing a target value of 110° C. to 145° C. for the temperature of the reaction mixture and using the actual temperature of the reaction mixture for closed-loop control of the temperature of the solution of the primary amine and/or of the temperature of the solution of phosgene.
US10851044B2	Method for preparing glutamate-based surfactant The present invention relates to a method for preparing a glutamate-based surfactant. More specifically, the present invention provides a method for preparing a glutamate-based surfactant, the method being very economical and being capable of mass production of the glutamate-based surfactant.
US10851042B2	Solubization of resveratrol glycolate and tartrate derivatives A process for solubilizing a resveratrol glycolate compound by heating the resveratrol glycolate and mixing the resveratrol glycolate with one or more glycols is disclosed. The process comprises an initial heating step of the resveratrol compound to a temperature not greater than 45° C. and a mixing step that mixes the heated resveratrol glycolate compound with at least one glycol solvent at room temperature for ten minutes to one hundred and twenty minutes.
US10851032B2	Dehydrohalogenation reactor and process The invention provides a reactor comprising a reaction chamber having a catalytic surface in contact with reactants in said chamber, and a source for passing electrical current through said catalytic surface. The reactor can be used for dehydrohalogentation reactions, such as dehydrochlorination of HCFC-244bb to HFO-1234yf and for reactions where zero valent metals are employed for catalysis. The invention further provides a process to prepare HFO-1234yf from HCFC-244bb using an electrically heated reaction chamber.
US10851030B2	Use of a bifunctional catalyst based on IZM-2 with a specific Si/Al ratio for the isomerization of long paraffinic feedstocks to middle distillates The present invention describes a process for the isomerization of paraffinic feedstocks operating at a temperature of between 200° C. and 500° C., at a total pressure of between 0.45 MPa and 7 MPa, at a hydrogen partial pressure of between 0.3 and 5.5 MPa, at an hourly space velocity of between 0.1 and 10 kilograms of feedstock introduced per kilogram of catalyst and per hour and using a catalyst comprising at least one metal of group VIII of the periodic table of elements, at least one matrix and at least one zeolite IZM-2, in which the ratio between the number of moles of silicon and the number of moles of aluminium of the zeolite IZM-2 network is between 25 and 55, preferably between 25 and 50, and preferably between 30 and 50.
US10851027B2	Phosphorus fertilizer bio-catalyst for sustainable crop production Endophytic microbial strains as biocatalysts isolated from fresh plant samples, compositions, and methods of use thereof to enhance the growth and/or yield of a plant in the presence of reduced synthetic phosphate fertilizers are provided. Endophytic microbial strains serve as biocatalysts to solubilize mineral-P and mineralize organic-P otherwise unavailable to plants for their nutritional phosphate needs. Thus defined, biocatalysts, will serve to replace synthetic phosphate fertilizers. Also provided are materials and methods for inoculating plants with these biocatalysts at carefully selected inoculum densities to reliably reduce the amount of synthetic phosphate fertilizer by 50% thus accomplishing obtaining optimal yields in technically and cost-effective manner.
US10851021B2	Article having coating including compound of aluminum, boron and nitrogen An article includes a monolithic substrate and a coating on the monolithic substrate. The monolithic substrate is selected from graphite, silicon carbide, silicon carbide nitride, silicon nitride carbide, and silicon nitride. The coating has a free, exposed surface and includes a compound of aluminum (Al), boron (B) and nitrogen (N) in a continuous chemically bonded network having Al—N bonds and B—N bonds. The compound includes an atom of nitrogen covalently bonded to an atom of boron and an atom of aluminum, and the compound has a composition BxAl(1-x)N, where x is 0.001 to 0.999.
US10851020B2	Machinable metal matrix composite and method for making the same A metal matrix composite comprises and/or consists of a uniform distribution of calcined ceramic particles having an average particle size of between 0.30 and 0.900 microns and a metal or alloy uniformly distributed with the ceramic particles and wherein the ceramic particles include oxides of two separate metals selected from the group consisting of Al, Li, Be, Pb, Fe, Ag, Au, Sn, Mg, Ti, Cu, and Zn, and in which said ceramic particles comprise at least 15 volume percent of the metal matrix sintered together and wherein said metal-matrix being machinable with a high speed steel (HSS) bit for greater than about one minute without excessive wear to the bit.
US10851013B2	Glass sheet acquisition and positioning system and associated method for an inline system for measuring the optical characteristics of a glass sheet A glass sheet acquisition and positioning system and associated method are utilized in a glass sheet optical inspection system installed in-line in a glass sheet processing system. The acquisition and positioning system include an exterior support frame and a moveable glass sheet support frame connected to the exterior support frame such that the glass sheet support frame may be selectively positioned from first orientation whereby a glass sheet is removed from a conveyor and retained on the support frame, to a second orientation whereby the glass sheet is positioned for processing by the optical inspection system. The system may also include a glass sheet part identifier and a programmable control including logic for analyzing acquired image data and identifying the glass sheet as one of a set of known part types and thereafter securing and positioning the glass sheet on the glass sheet support frame based upon the part-shape analysis.
US10851012B2	Glass plate production method, glass plate, glass article production method, glass article, and glass article production apparatus A glass plate production method includes (1) preparing a glass material having a first main surface and a second main surface opposite to each other; (2) irradiating the first main surface of the glass material with a laser to form an in-plane void region having a plurality of voids arranged on the first main surface, and forming a plurality of internal void rows each having one void or two or more voids arranged from the in-plane void region toward the second main surface of the glass material; and (3) chemically strengthening the glass material having the internal void rows formed therein.
US10851011B2	System and method for fire-polishing glass containers A system and method for fire-polishing glass containers includes at least one fixed structure positioned on each side of a conveyor belt, in the forward movement direction of the glass containers; a structure that can move via each of the fixed structures, which moves with a forward movement in relation to the forward movement line of the conveyor belt, and with a backward movement in relation to the forward movement of the conveyor belt; a series of burners coupled to each of the moveable structures; sensors positioned on one side of the conveyor belt to determine the speed of the carrier belt and the distance or separation between containers; and a controller connected to the sensor and moveable structure, for adjusting and synchronising the speed and distance of the containers.
US10851007B1	System for processing Red Mud and method of processing Red Mud A system for processing red mud comprising: a first heating section controlled to heat red mud to a first temperature; a second heating section controlled to heat the red mud to a second temperature lower than the first temperature; a crusher configured to grind the red mud to a predetermined particle size; and one or more separators for physically extracting at least iron and aluminum from the red mud.
US10851006B2	Supercritical water oxidation reactor and process The present invention relates to supercritical water oxidation reactor adapted to contain inside the reactor an aqueous fluid below and above its supercritical state, said fluid comprising organic and/or inorganic material and a method of controlling such a reactor.
US10851001B2	Technologies for sanitizing reservoirs Technologies (e.g., devices, systems and methods) for sanitizing reservoirs are described. In some embodiments, the technologies include a sanitization gas system and a connector unit or a hole in the reservoir wall, configured to connect a supply line to the reservoir. The connector unit may include an inlet passageway for supplying sanitizing gas (e.g., ozone) into the reservoir.
US10850997B2	Method of boron-contained wastewater treatment A method of boron-contained wastewater treatment includes the following steps. Pretreatment: Mix a boron-contained wastewater with hydrogen peroxide for reaction at pH 8-12. Precipitation: Add n moles of barium compound into the pretreated boron-contained wastewater to provide perborate precipitation at pH 8.5-12. The number n is obtained from an equation of n=([B]a+[NO3]0.01+[F]0.01+[CO3]1+[SO4]1)V wherein a is ranged from 0.6-0.9. [B], [NO3], [F], [CO3], and [SO4] are molarities of boron, nitrate ion, fluoride ion, carbonate ion, and sulfate ion of the boron-container wastewater. V is the volume of the boron-container wastewater. A fluidized bed reactor is used.
US10850993B2	Method for making and using an adsorbent Methods and nanocomposites for the adsorptive removal of aromatic hydrocarbons such as benzene, toluene, ethyl benzene and xylene from contaminated water sources and systems are provided. The nanocomposites contain carbon nanotubes and metal oxide nanoparticles such as Al2O3, Fe2O3 and ZnO impregnated on a surface and/or in pore spaces of the carbon nanotubes. Methods of preparing and characterizing the nanocomposite adsorbents are also provided.
US10850990B2	Method for processing magnesium chloride solutions and method for manufacturing carboxylic acids Magnesium chloride solutions including providing aqueous magnesium chloride solution with magnesium chloride concentration of 10-30 wt. % to concentration step where water is evaporated, resulting in concentrated magnesium chloride solution with magnesium chloride concentration of 30-50 wt. %, wherein concentration step is carried out in one or more stages, wherein at least one of the stages is conducted at elevated pressure, withdrawing concentrated magnesium chloride solution from concentration step, and providing it to thermohydrolysis reactor of at least 300° C., withdrawing MgO from thermohydrolysis reactor in solid form, and withdrawing a HCl containing gas stream of at least 300° C. from thermohydrolysis reactor, providing the HCl-containing gas stream of at least 300° C. to cooling step, where HCl-containing gas stream is contacted with cooling liquid, withdrawing HCl-containing gas stream below 150° C. from cooling step, circulating cooling liquid through heat exchanger where energy is transferred to heating liquid which circulates from heat exchanger to concentration step.
US10850988B2	Process for synthesizing zeolite crystals with seeding agent The present invention relates to process for synthesizing zeolite X crystals comprising at least one step of adding seeding agent(s) into a synthesis gel and at least one step of forming zeolite X crystals at a temperature strictly greater than 120° C., preferably equal to or greater than 130° C.
US10850984B2	Synthesis of high quality carbon single-walled nanotubes Methods and processes for synthesizing high quality carbon single-walled nanotubes (SWNTs) are provided. A carbon precursor gas at reduced concentration (pressure) is contacted with a catalyst deposited on a support and at temperature about 10° C. above the SWNT synthesis onset temperature, but below the thermal decomposition temperature of the carbon precursor gas for given growth conditions. The concentration (pressure) of the carbon precursor gas can be controlled by reducing the total pressure of the gas, or by diluting with an inert carrier gas, or both. The methods produce SWNTs with the ratio of G-band to D-band in Raman spectra (IG:ID) of about 5 to about 200.
US10850981B2	Methods of producing a gas at a variable rate Disclosed herein are methods of producing a gas at a variable rate, the methods comprising dynamically mixing dry particles comprising a precursor and dry particles comprising a proton-generating species to produce a gas and wherein the gas is produced at a rate that is varied by varying the amount of time the dry particles comprising the precursor and the dry particles comprising the proton-generating species are dynamically mixed, the rate at which the dry particles comprising the precursor and the dry particles comprising the proton-generating species are dynamically mixed, or a combination thereof.
US10850980B2	System and process for generating hydrogen gas A system for producing gaseous hydrogen, includes an enclosure formed by a side wall, a front end wall, and a rear end wall, the enclosure containing unit charge(s) of a material for generating gaseous hydrogen when heated, wherein each unit charge includes a cylindrical body including a closed rear end wall and a front end wall having an opening, at least one block of material for generating gaseous hydrogen, each block presenting an annular shape defining a central channel leading to the opening in the front end wall of the body and an initiator present in the vicinity of the rear end wall of the body; the opening facing the front end wall of the enclosure so that the hot gas coming from the block of material for generating gaseous hydrogen when heated is directed directly against the inside surface of the front end wall of the enclosure.
US10850976B2	Method of making ohmic contact on low doped bulk silicon for optical alignment Various embodiments of the present disclosure are directed towards a method for forming an integrated chip including an epitaxial layer overlying a microelectromechanical systems (MEMS) substrate. The method includes bonding a MEMS substrate to a carrier substrate, the MEMS substrate includes monocrystalline silicon. An epitaxial layer is formed over the MEMS substrate, the epitaxial layer has a higher doping concentration than the MEMS substrate. A plurality of contacts are formed over the epitaxial layer, the plurality of contacts respectively form ohmic contacts with the epitaxial layer.
US10850975B2	Physical quantity sensor manufacturing method, physical quantity sensor, electronic device, and vehicle A manufacturing method of a physical quantity sensor includes forming first and second fixed electrodes, and a dummy electrode on a substrate; and a movable body forming. The electrode forming includes forming a first mask layer on the substrate, forming a first electrode material layer by forming a first conductive layer on the substrate and the first mask layer, forming a second conductive layer on the substrate and the first electrode material layer, forming a second mask layer by forming a mask material layer on the second conductive layer, and removing a part of a section of the mask material layer not overlapping the first electrode material layer in plan view, and forming a second electrode material layer by etching the second conductive layer, with the second mask layer as a mask such that the second conductive layer is provided on the first electrode material layer and on the substrate.
US10850974B2	Microelectromechanical systems (MEMS) and methods The present disclosure relates to a method of fabricating a reflector, the reflector being at least partially reflective and at least partially transmissive for at least a wavelength of electromagnetic radiation; the method comprising: forming a first material layer defining a bottom layer; forming a sacrificial layer on the bottom layer; forming a second material layer defining a top layer on the sacrificial layer and a supporting structure connected to the bottom layer; and removing at least part of the sacrificial layer to form a cavity between the bottom layer and the top layer such that the supporting structure supports the top layer relative to the bottom layer and no further supporting structure is provided within the cavity, wherein after the at least part of the sacrificial layer is removed, at least the top layer has residual tensile stress.
US10850965B2	Needle for accessing a beverage in container A needle for accessing a container having a closure, such as a cork of a wine bottle. The needle includes first and second lumens each having a D-shaped cross section and a flat surface. The first and second lumens are attached with the flat surfaces in contact, and each lumen may have an outlet opening at a distal end. The needle may be used with a beverage dispenser that operates by introducing gas into a container via one lumen, and receives beverage from the container via another one of the lumens.
US10850962B2	Clamping device for a forklift and a forklift having such a clamping device The invention relates to a clamping device (5) for a forklift (1). The clamping device (5) comprises a body (6) connectable to the forklift (1) at a loading area thereof, a clamping arm (7) connected to the body (6), the clamping arm (7) being moveable in relation to the body (6), and a drive unit arranged to move the clamping arm (7) between an idle position, in which the clamping arm (7) is located outside of the loading area, and a working position, in which the clamping arm (7) has been moved into the loading area to secure a load (2) carried by the forklift (1). The invention also relates to a forklift (1) for transporting a load (2).
US10850959B2	Storage and retrieval device for parallel operation of a high-bay warehouse and operating method therefor A storage and retrieval device, in particular for parallel operation of a high-bay warehouse, contains a device frame, which has frame compartments arranged to form a three-dimensional compartment matrix, and has at least one cab used to hold storage goods. The electromotively driven cab can be moved within the compartment matrix in a vertical direction and/or in a second horizontal direction from each frame compartment. The storage and retrieval device advantageously realizes fast access because of the movability of the cab within a device frame of the storage and retrieval device in a vertical direction and/or in a second horizontal direction and realizes a high handling rate of storage goods in the operation of a high-bay warehouse because of the parallel operation of a plurality of cabs.
US10850955B2	Controller for hoist capable of multi-stage speed control and hoist including the same controller Disclosed herein is a controller of a hoist. The controller of a hoist includes a lift up button which is adjustable in a pressed degree; a lift down button which is adjustable in a pressed degree; lift up button contacts configured to allow ascending direction control power to flow to a motor when the lift up button is pressed; lift down button contacts configured to be in contact when the lift down button is pressed and allow descending direction control power to flow to the motor; a magnet accommodated in each of the lift up button and the lift down button; and a Hall sensor disposed to detect a descending degree of the magnet accommodated in each of the lift up button and the lift down button.
US10850954B2	Hoisting machine arrangement and method for preparing gear thereof A hoisting machine arrangement includes a rope drum, which has a driven gearwheel; a hoisting motor for driving the rope drum; and a gear between the hoisting motor and the rope drum. The gear has a body and a driving gearwheel, the driving gearwheel of the gear being coupled to the driven gearwheel of the rope drum. The body of the gear has a first drilling, which is arranged for fitting a shaft of the driving gearwheel; and a second drilling, which is parallel to the first drilling and arranged for fitting a shaft of the rope drum or the like. A method is disclosed for preparing a gear of a hoisting machine arrangement of this type.
US10850951B2	Mobile crane comprising a ballast receiving device and method for ballasting a mobile crane The invention relates to a mobile crane having at least one ballast receiver that is vertically adjustable via one or more ballast cylinders and having a coupling for connecting the ballast cylinder or cylinders to the energy supply of the crane, wherein the energy supply can be releasably connected to the at least one ballast cylinder via at least one coupling part.
US10850949B2	Remote control device for a crane, a construction machine and/or for a pallet truck The present invention relates to a remote control device for a crane, for a construction machine and/or for a pallet truck comprising a control station that has at least one input means for inputting control commands and that has a signal transmission device for transmitting the input control commands to the control apparatus of the crane, of the construction machine, or of the pallet truck; and a display apparatus for displaying a representation of the machine surroundings and/or of a piece of working equipment such as a boom or a lifting hook, wherein a movement determination unit is provided for determining movements and/or deformations of the machine components in dependence on the input control commands. It is proposed to present crane reactions or machine reactions to control commands input at the control station, for example in the form of crane movements and/or of crane deformations not only in the form of a representation on the display apparatus, but to convert them into an actual movement of the control station of the remote control accompanying the crane reaction or machine reaction to allow the remote control user to have the dynamic machine reactions communicated to him more realistically and to experience them more realistically.
US10850947B2	Misalignment monitoring in a people conveyor A people conveyor (1) comprises a truss (2) extending between two landing portions (20, 21); a band (12) of conveyance elements (13) forming a closed loop extending in a conveyance direction between the two landing portions (20, 21); a drive machine (25) configured for driving the band (12) of conveyance elements (13); and at least two magneto-inductive sensors (36a, 36b, 36c) mounted to the truss (2). The at least two magneto-inductive sensors (36a, 36b, 36c) are configured for providing sensor signals which allow determining the position and orientation of the drive machine (25) with respect to the truss (2).
US10850945B2	Traction geared machine for elevator A machine assembly for use in an elevator system is provided including a drive sheave (52) configured to rotate about a first axis of rotation (R). A first roller shaft (54) is configured to rotate about a second axis of rotation (S) substantially parallel to the first axis of rotation. Rotation of the first roller shaft about the second axis of rotation is configured to rotate the drive sheave about the first axis of rotation. A first motor is operably coupled to the first roller shaft and is configured to rotate the first roller shaft about the second axis of rotation.
US10850942B2	Roller guide for a car of an elevator system A roller guide for guiding a car of an elevator system along a guide rail may include a roller carrier that can be attached to the car and several rollers disposed on the roller carrier. The roller may be configured to roll by their respective running surface on a rolling surface of the guide rail. The rollers may each be mounted movably in the roller carrier with a direction component perpendicular to the rolling surface of the guide rail. The rollers may be mounted in operative connection with one another at least in part by way of hydraulic fluid such that a movement of one of the rollers perpendicular to the rolling surface of the guide rail causes a directionally-opposite movement of at least a second of the rollers. The present disclosure also concerns a car and an elevator system that employ such roller guides.
US10850941B2	Communication with a passenger in a transportation system A method to communicate with a passenger in a car within a transportation system includes receiving an alarm signal from the car, and initiating a text communication session via a communication system associated with the car in response to the alarm signal.
US10850939B2	Systems and methods for folding a stack of substrate sheets Systems and methods for folding a stack of substrate sheets are provided. The system may include a roller assembly and a positioning mechanism. The roller assembly is configured for folding the stack of substrate sheets and the positioning mechanism is configured to position the substrate or stack for entry into the roller assembly. The positioning mechanism includes an upper curved for and a lower curved form to guide the stack of substrate sheets into a curved position for folding. The positioning mechanism further includes a folding blade positioned to extend through the gap between the upper and lower curved forms. The roller assembly can move the folded stack of substrate sheets in at least two directions.
US10850935B2	Document feeder assisting device and image forming apparatus incorporating automatic document feeder including the document feeder assisting device A document feeder assisting device includes a document stacker to stack a document to be conveyed toward a feed port of an automatic document feeder, a pressing device to press the document toward a document placement surface of the document stacker, and a conveyance device to convey the document. The document is stacked on the document placement surface exposed above with the pressing device moved.
US10850930B1	Product diverter for a reciprocally movable conveying device An automated product diverter for a reciprocally movable conveying device generally provides a stationary base; a reciprocally movable conveyor bed supported by the stationary base; a product diverter that moves in an arc along a product transporting surface of the reciprocally movable conveyor, and an actuator carried by the stationary base and which operatively communicates with the diverter arm, and the reciprocal movement of the conveyor bed and the diverter arm is isolated from the actuator carried by the stationary base.
US10850928B1	Conveyor sensor Some embodiments of the technology disclosed herein relate to a sensor device. An elongate sleeve has a first end and a second end and extends along a longitudinal axis. A plurality of sensors are fixed relative to the sleeve. A first endcap is coupled to the first end, where the first endcap has an endcap body. A first axle is coupled to the endcap body, where the first axle extends along the longitudinal axis and the first axle defines a retaining feature. An intermediate component is coupled to the first axle, and the intermediate component is selectively rotatable about the longitudinal axis. The sensor device has an orientation locking structure that is configured to be engaged to selectively fix the orientation of the intermediate component about the longitudinal axis relative to the endcap body.
US10850917B2	Mobile dehydrator and method of use thereof A fully self-contained, portable product dehydrator is provided comprising: an intermodal container housing an equipment module, the equipment module including a refrigeration equipment chamber proximate the front door and an air conditioning chamber behind the refrigeration equipment chamber, the equipment module retained in the interior and moveable from a retracted position to an extended position, wherein when in the extended position, the refrigeration equipment chamber is substantially exposed to an ambient environment, outside the front door; a heat pump dehumidifier including a subcooler, a desuperheater, electronic expansion valve and a compressor, housed in the refrigeration equipment chamber and at least two condensers and evaporator housed in the air conditioning chamber; a drying chamber, the drying chamber defined by the interior and the rear door; a motor control center; and a control panel; in electronic communication with the heat pump dehumidifier and the fans.
US10850914B2	Dip tube aerosol dispenser with upright actuator An aerosol foam dip tube dispenser with an axis of symmetry with a pressurizable outer container for storing a propellant and a composition under pressure and an actuator. The aerosol dispenser is ergonomic and promotes upright dispensing in order to avoid degassing.
US10850910B2	Multilayer polyester film for ready meals Coextruded, biaxially oriented multilayer films comprising a base layer comprising a polyester having an intrinsic viscosity greater than 0.75 dl/g and a heat-sealable layer directly adhered to said base layer, said heat-sealable layer comprising an amorphous polyester having a melting temperature not higher than the melting temperature of the polyester of the base layer and a thermoplastic resin characterized in that the heat-sealable layer comprises a further polyester resin are described. Also packages comprising a container, a food product and the above coextruded, biaxially oriented multilayer film are described. The packages are particularly suitable for “ready-meals” to be used in conventional oven at high temperatures.
US10850909B2	Disposable ingredient-dispensing apparatus A disposable ingredient-dispensing apparatus selectively dispenses one or more ingredients. The disposable ingredient-dispensing apparatus includes a substantially circular base member comprising multiple chambers circumferentially positioned along the base member, and a ring frame configured to be rotatable circumferentially along a surface of the base member. Each chamber is filled with the one or more ingredients, and is sealed with a diaphragm. The ring frame comprises a rupturing member positioned at a predefined section of the ring frame, and the ring frame is rotated to selectively align the rupturing member to enclose one of the chambers, and the rupturing member contacts the aligned chamber to rupture the diaphragm for selectively dispensing the ingredients.
US10850908B2	Packaging and shipping blocks for flat-panel products Described herein are shipping blocks for packaging and shipping flat-panel products. The blocks have chamfered edges to allow the block to slide across uneven surfaces; at least one of slots or alignment tabs to secure the product to the block; and, walls that are configured to flex when pressure or stress is applied to the block.
US10850907B2	Air-filling packaging apparatus An air-filling packaging apparatus includes at least an air cushion body formed by at least two layers of air chamber films. The air cushion body includes multiple air-storing units. The air-storing units are heat-sealed to form a series of 2D heat-sealing seams, folded, and heat-sealed to form a series of 3D heat-sealing seams so as to make a 3D packaging bag for packaging an object to be packaged. The 3D packaging bag provides a cushioning function for the object to be packaged.
US10850906B2	Air cushion machine and method A method of producing air cushions with an air cushion machine for cushioning at least one item to be shipped in a box comprises the steps of determining a void volume defined by a difference between a volume of the box and a volume of the at least one item to be shipped in the box, and producing a quantity of air cushions with the air cushion machine having a total air cushion volume, the total air cushion volume being equal to the void volume.
US10850904B2	Re-sealable flexible package with reinforced perimeter Improved packages and methods for constructing packages are provided that reduce or prevent leakage into or out of the package. In particular, the package includes a base member and a lidding member with a reinforced perimeter portion that blocks channels that may form at the interface between the base member and the lidding member from extending to the edge of the base member, such that, e.g., liquids have no path to the package exterior. The perimeter portion may be a thicker region of a first film of the lidding member (e.g., a polyethylene emulsion), or the perimeter portion may be formed using permanent adhesive. Frangible layers and/or cut lines may be defined in the material of the base member or the lidding member to allow a controlled break to occur when the lidding member is peeled away from the base member to provide access to the package contents.
US10850900B2	Process for individually marking a medical product present under film or in a bag and marked product A process for the marking of a film or a bag, which consists of a film at least in sections, wherein the film or the bag comprises a medical product or is provisioned or prepared for the uptake of such, wherein the process comprises connecting a film strip with, in, to and/or on the film, wherein the film strip carries information for marking the medical product.
US10850895B2	Closure cap Closure cap intended to close off an open end of a reservoir, comprising a substantially cylindrical body (12) of longitudinal axis (Z) that is intended to be mounted on the open end of the reservoir and is provided with a flow orifice (12e) and a lid (14) that is articulated about a transverse pivot axis (A0) with respect to the body (12), by means of at least two hinges (16), between an open position of the flow orifice (12e) and a closed position of said flow orifice (12e), said lid (14) having an outside diameter greater than the outside diameter of the body (12) and forming a radial lip, said closure cap (10) also comprising a return member (18) that is disposed in a plane passing between the two hinges (16) and is able to keep the lid (14) in each of the positions. The return member (18) has a bent shape configured to be inserted into cavities (12f, 14d) made in the body (12) and in the lid (14), respectively, and to be flush with the radial lip of the lid (14) in the closed position.
US10850893B2	Dispensers with diverter inserts A dispenser for dispensing a viscous material contained in a flexible package has a hollow body extending along a longitudinal axis, a first end with a handle assembly, an opposite second end with a dispensing valve, and a cavity configured to receive the flexible package. A piston is movably disposed in the cavity for engagement with the flexible package to force viscous material from the flexible package. A diverter insert is also disposed in the cavity and is configured to receive the viscous material from the flexible package as the piston moves and divert the viscous material to the dispensing valve.
US10850891B2	Full recycling environmental protection packaging structure and manufacturing method thereof A full recycling environmental protection packaging structure and a manufacturing method thereof applied to express deliveries, postal services and logistics and made of a planar structure of paper. The packaging structure includes a first surface and a protecting layer overlapped on the first surface. The protecting layer includes at least one layer of liner which is a three-dimensional network structure formed by paper material being stretched after being die-cut. The planar structure is sealed edges thereof and an opening is reserved to form a bag body. The packaging structure of the present disclosure can overcome problems that kraft paper bubble bags or envelopes, and paper and plastics can't be separated and recycled to pollute environment in the prior art. At the same time, it can solve technical problems of dust pollution and poor air quality caused by using powdery and granular soft structures used as buffers.
US10850888B2	Concave can end A container can end includes a concave dome shape and may forgo a peripheral reinforcing bead around the center panel. The tab may also be curved. Tooling for forming the end and a corresponding method are provided.
US10850886B2	Rear holder and motor comprising same The present invention may provide a rear holder comprising: a first body comprising a first groove; a second body comprising a second groove; a coupling portion for coupling the first body and the second body such that the first groove and the second groove are aligned, thereby constituting a cable hole; and a rib, wherein the rib is arranged so as to protrude along at least one selected from the boundary between the front surface of the first body and the first groove and the boundary between the front surface of the second body and the second groove.
US10850884B1	Method and apparatus for debris collection and hauling A debris collection assembly can be alternatively configured to form: (i) a chute or bag holder and/or (ii) a bag hauler that can be utilized with conventional bags. The debris collection assembly can be formed from at least one planar member that can be selectively folded or otherwise configured to form a chute apparatus that can serve as a guide for directing loose debris into a bag. The planar member of the debris collection assembly can be removed from the bag and selectively reconfigured to form a hauler for selectively transporting a bag and its contents of desired distances.
US10850882B2	Self closing and opening filling needle, needle holder, filler and method An apparatus for filling a device having a penetrable septum and a sealed chamber. The apparatus includes a filling member engageable with the penetrable septum to penetrate the septum, port(s), and a closure. The closure and filling member are movable between (i) a first position wherein the closure closes the port(s), and (ii) a second position opening the port(s). The filling member and/or septum is movable relative to the other between (i) a first position wherein the filling member is spaced from the septum, and (ii) a second position wherein the filling member is penetrated through the septum and in communication with the sealed chamber. A locking device is movable between (i) a locked position locking the closure and/or filling member in the first position, and (ii) an unlocked position allowing movement of the closure and/or filling member relative to the other and into the second position.
US10850881B2	Method and apparatus for reconfiguring containers Methods and apparatus for forming containers from container blanks are provided. An apparatus comprises a blank holding apparatus operable to releasably hold a plurality of carton blanks in a first configuration. The apparatus also has a rotary apparatus operable to rotate an engagement device along a rotational path from a first retrieval location where the engagement device is operable to engage with and retrieve a blank from the plurality of blanks held in the blank holding apparatus, to a second operational location. The apparatus also has a movement apparatus inter-connected to the rotary apparatus. The movement apparatus is operable to move the rotary apparatus and the engagement device with the engaged blank away from the blank holding apparatus, which may be translational movement away from the blank holding apparatus.
US10850876B2	Apparatus and process for packaging products It is described an apparatus (1) for packaging a product (P) comprising: a forming station (2) configured for receiving a base film (3) and for forming with it a precursor body (4) having a plurality of tray-shaped elements (5) adjacent to each other, and a packaging station (8) configured for receiving said precursor body (4) and a closing film (9), the packaging station (8) being configured for attaching the closing film (9) to the precursor body (4) at least at an upper opening (5a) of a predetermined number of said tray-shaped elements (5) for forming packages (C) flanked to each other. A movement device (13) is configured for moving at least one of said forming (2) and packaging stations (8), for conferring to the precursor body (4) a step-by-step discontinuous movement along a predetermined advancement path (T). It is also described a packaging process using the apparatus (1).
US10850873B2	Apparatus and method for asepticaly filling pharmaceutical containers with a pharmaceutical fluid using rotary stage Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.
US10850867B2	Cradle assembly for supporting a door for uninstalling or installing to an aircraft, and arrangements and methods for the same Cradle assemblies for supporting a door for one of uninstalling and installing the door to a fuselage of an aircraft, and arrangements and methods for the same are provided. In one example, a cradle assembly includes a first contoured board configured to support a first outer section of the door. A second contoured board is spaced apart from the first contoured board and is configured to support a second outer section of the door. The cradle assembly is configured to be positioned proximate to the fuselage.
US10850864B2	Electronic avionics systems and methods The present general inventive concept relates to a system of method having an electronic flight display that meets the FAR 23.1311(b) regulatory requirement for redundant backup instruments in the cockpit. The present general inventive concept also provides a system and method to detect failures, obstructions, or improper operation of the aircraft pitot pressure sensing system using a combination of dissimilar sensor data that is independent from each other, e.g., allocated from different sources and employed for different purposes on different displays, and displays information on an avionics display screen.
US10850855B2	Catalytic ozone removal A method is disclosed for removing ozone from a gas. According to this method, the gas is contacted with an adsorbent that includes a transition metal oxide or metal organic framework to form a treated gas. The treated gas is contacted with a noble metal catalyst to catalytically decompose ozone in the treated gas, thereby forming an ozone-depleted treated gas.
US10850852B2	Methods for arranging passenger seats and passenger service units in aircraft cabins Disclosed are methods for arranging passenger seats and passenger service units in aircraft cabins as well as locating devices used in these methods. These methods and devices provide fast and efficient ways for directly referencing the position of each passenger service unit relative to a corresponding passenger seat. For example, a passenger seat is positioned on a seat rail using rail markers. Each set of markers corresponds to a different seating configuration. A locating device is then placed on the passenger seat such that the device datum contacts the seat cushion. A locator of the locating device determines a reference, in an overhead compartment, for installing a passenger service unit, corresponding to this seat. The reference is based on an angle between the datum and the locator, which is adjustable in some examples.
US10850846B2	Foot washing systems and methods A foot washing system includes a support panel, and a basin including a foot-washing area and a drain that is configured to drain water out of the foot-washing area. The basin is moveably coupled to the support panel. The basin is selectively moveable between a stowed position and a deployed position in relation to the support panel. The deployed position allows for foot washing within the foot-washing area.
US10850844B2	Mobile platform cabin configured for passenger and cargo transport The mobile platform cabin (20) disclosed herein comprises a passenger portion (22), a first cargo portion (24) disposed aft of the passenger portion (22), a partition (36) separating the passenger portion (22) from the first cargo portion (24), a second cargo portion (26) disposed aft of the first cargo portion (24) and a barrier net (38) separating the first cargo portion (24) from the second cargo portion (26). The first cargo portion (24) comprises a cargo-receiving zone (40) and a stay-out zone (44) in which cargo is not permitted. The barrier net (38) is configured to distend into the first cargo portion (24) when restraining forward movement of cargo (48) in the second cargo portion due to the cargo (48) in the second cargo portion being subjected to an acceleration relative to the cabin. At least part of the distension of the barrier net (38) is accommodated by the stay-out zone (44) of the first cargo portion (24).
US10850843B2	Roller assembly of a cargo loading system A cargo handling system that enables rollers to swivel without the need for the inclusion of metal thrust bearings. A method of assembling and retrofitting existing conventional type swivel caster style wheels is also provided.
US10850840B2	Drone and rover preplacement for remote autonomous inspection of utility system components Unmanned monitoring devices, such as unmanned aerial vehicles (UAV), drones or rovers may survey an area of interest (AOI) such an electric power distribution system including generation, transmission, and distribution elements to automatically determine components in the AOI to be monitored. Types, placements locations, and pathways taken by other unmanned monitoring devices to facilitate the monitoring of the components of the AOI are also automatically determined.
US10850839B2	Unmanned aerial vehicle (UAV) for collecting audio data An unmanned aerial vehicle (UAV) with audio filtering components includes a background noise-producing component, a background microphone, and a noise emitter. The background noise-producing component is configured to produce a background noise. The background microphone is positioned within a proximity sufficiently close to collect interfering noise from the background noise producing component. The background microphone is configured to collect audio data including the background noise. The noise emitter is disposed within a proximity sufficiently close to the background noise-producing component to reduce the interfering noise. The noise emitter is configured to emit an audio signal having a reverse phase of the audio data collected by the background microphone.
US10850838B2	UAV battery form factor and insertion/ejection methodologies The present disclosure is related to unmanned aerial vehicles or drones that have a capability of quickly swapping batteries. This may be accomplished even as the drone continues to fly. A drone consistent with the present disclosure may drop one battery and pickup another using an attachment mechanism. Attachment mechanisms of the present disclosure may include electro-magnets, mechanical actuators, pins, or hooks. Systems consistent with the present disclosure may also include locations where replacement batteries may be provided to aircraft via actuation devices coupled to a physical location.
US10850837B2	Air vehicle flight mechanism and control method for non-sinusoidal wing flapping A flapping wing driving apparatus includes at least one crank gear capstan rotatably coupled to a crank gear, the at least one crank gear capstan disposed radially offset from a center of rotation of the crank gear; a first wing capstan coupled to a first wing, the first wing capstan having a first variable-radius drive pulley portion; and a first drive linking member configured to drive the first wing capstan, the first drive linking member windably coupled between the first variable-radius drive pulley portion and one of the at least one crank gear capstan; wherein the first wing capstan is configured to non-constantly, angularly rotate responsive to a constant angular rotation of the crank gear.
US10850835B2	Unmanned aerial vehicle with monolithic wing and twin-rotor propulsion/lift modules Various embodiments include a drone capable of operating as an airplane, a quad-copter, or a hybrid aircraft using a versatile flight performance envelope enabled by six elements of control. The drone may include a monolithic wing with a propulsion/lift module connected to each wing tip. Each propulsion/lift module may include a pivotal support structure configured to pivot around a longitudinal axis of the monolithic wing, with two pylons extending radially outwardly from the pivotal support structure and at least partially away from one another, and a propulsion units positioned on a distal end of each pylon. The pivotal support structures may be coupled to the monolithic wing via a servo motor enabling a processor to individually control rotation of each propulsion/lift module to provide roll and pitch control. Thrust and rotation of the propulsion units may be individually controlled by the processor to provide yaw, roll and pitch control.
US10850832B2	Lifting surface of an aircraft for increasing the generated lift force A lifting surface of an aircraft, comprising a leading edge and a notch located in the leading edge. The notch comprises two walls adapted to be parallel to the direction of the incident flow to the lifting surface and a third wall adapted to face the incident flow to the lifting surface when it is in flight. The lifting surface also comprises a retractable cover element, the notch and the retractable cover element being configured such that when the retractable cover element does not cover the notch, the notch is exposed to the incident flow generating a vortex which increases the lift force of the lifting surface, delaying stall.
US10850830B2	Thrust reversal on aircraft fuselage with a wing profile An aircraft includes a fuselage having a wing profile. An apparatus for thrust reversal is disposed on the tail of the aircraft. Air feed takes place from the outside, by way of a braking flap with an air intake channel and/or from a propelling machine.
US10850826B2	Aircraft wing space frame Aircraft wings have an interior volume that incorporates a space frame as a primary supporting structure of the wing, and enables securement of an aircraft fuselage to the wing. The space frame includes carbon fiber rods arranged to handle tensile and compression loads otherwise carried by conventional wing spars, ribs, and stringers normally connected to heavy structural metal wing box joints at the sides of a fuselage for attachment of left and right wings. The space frame also includes sleeve and shaft connectors secured to the carbon fiber rods, the connectors arranged in truss-like configurations for preventing buckling of the carbon fiber rods. The space frame is designed to extend at least midspan between wings, so that traditional wing box joints on a fuselage can be eliminated. Finally, wing skin panels secured to the space frame are designed to support only aerodynamic loads of flight.
US10850825B2	Cooling of a vaporized content of a liquefied gas for the purpose of powering machinery, plants or vehicles A fuel system for a liquefied gas drive system. The fuel system has a liquefied gas tank and a cooling system for the vaporized content of liquefied gas, which comprises a liquid nitrogen tank, a nitrogen pump, a heat exchanger, and a nitrogen cooler, which are connected to each other in a pipework circuit. The heat exchanger is arranged in the interior of the liquefied gas tank. Also disclosed are a vehicle, a plant and a machine, in each case with a fuel system, and a method for cooling the vaporized content of liquefied gas of a liquefied gas drive system.
US10850824B2	Redundant steering system for waterborne vessels A redundant steering system for watercraft that transfers rudder control to an electronic steering system when a hydraulic steering system either fails or is under repair. The electronic steering system utilizes either a fueled generator or a battery or series of batteries to power electric steering and flanking motors that serve control the angular position of the rudders.
US10850814B2	Large bore pierce pin for an inflator A pierce pin for an inflator for piercing the frangible seal of a gas cartridge including in combination a shaft having a axial bore forming a tubular member having a tip with a rim and a pair of slots formed across the rim into the tip into the tubular member to an appreciable depth to form a tab, the tab being bent inwardly into the axial bore after formation of the slots.
US10850810B2	Marine monitoring buoy with improved structure A marine monitoring buoy with an improved structure belongs to the technical field of marine buoys. The marine monitoring buoy includes a first buoy body, a cylindrical portion and a conical portion. A vertical through hole is disposed in the first buoy body, a horizontal through hole is disposed in an upper part of the cylindrical portion, an upper end of the vertical through hole extends to the cylindrical portion and is in communication with the horizontal through hole, a lower end of the vertical through hole penetrates through the conical portion, a wind power generator is disposed in the vertical through hole, two guiding grooves are disposed on a side wall of a lower part of the vertical through hole, a metal piston rod is disposed in the vertical through hole.
US10850808B2	Anchoring device An anchoring device may be arranged above or below a body of water and may secure or anchor watercraft to at least one vertical object and/or horizontally-positioned object. The anchoring device may provide a clamping mechanism that may secure the anchoring device to the at least one vertical object and/or horizontally-positioned object. The anchoring device may be integrated or fixed to watercraft, such as at a seat pedestal. The anchoring device also may be used without being integrated or fixed to watercraft.
US10850805B1	Bicycle A bicycle includes a bicycle body, a bicycle component, and a battery. The bicycle body has a frame including a down tube, a component mounting portion, and a seat tube. The bicycle component includes a bicycle drive unit. At least a portion of the bicycle component is arranged inside the frame. The battery is mounted on the bicycle to supply the bicycle component with electrical power. The battery is accommodated in the down tube. The frame further includes a first open portion to accommodate the bicycle component in the frame. Both the bicycle component and the battery are partly disposed outside the frame via the first open portion.
US10850804B1	Bicycle A bicycle includes a bicycle body, a bicycle component, and a battery. The bicycle body has a frame including a down tube, a component mounting portion, and a seat tube. The bicycle component includes a bicycle drive unit. At least a portion of the bicycle component is arranged inside the frame. The battery is mounted on the bicycle to supply the bicycle component with electrical power. The battery has an elongated shape. One end of the battery is entirely accommodated in the down tube, and another end of the battery is disposed outside the down tube.
US10850800B2	Bicycle drivetrain A bicycle drivetrain including a first shaft and a second shaft which rotate in opposing directions, a first pedal connected to a first pedal crank connected to the first shaft and a second pedal connected to a second pedal crank connected to a second shaft, an engaged first spur gear and second spur gear attached to the first shaft and the second shaft, respectively, a first slip clutch mounted to the first shaft and connected to a main sprocket and a second slip clutch mounted to the second shaft, a first sprocket and a second sprocket having the same direction of rotation and attached to the first slip clutch and the second slip clutch, respectively, a rear sprocket attached to a rear wheel and connected to the main sprocket, and a plurality of mechanical stops which prevent unwanted rotation of the bicycle drivetrain.
US10850797B2	Axles, such as for bicycles A suspension for a two-wheeled vehicle includes first and second fork legs. Each fork leg includes a dropout. Each dropout has an opening therethrough. At least a portion of one of the openings is threaded. Each of the dropouts includes a split-damp pinch bearing defining the opening and operable between an open position and a locked position, and a hand operable actuator pivoted to the bearing for operation thereof. The suspension further includes a one-piece axle. The axle is disposed through the openings. The axle has a threaded first end engaged with the threaded portion. The axle has an ergonomic grip formed at a second end. The bearing tightly engages an outer surface of the axle in the locked position, thereby rotationally coupling the axle to the dropout.
US10850789B2	Motorized transportation scooter A scooter includes a front platform and a driver platform rotatably connected to each other and each having a planar surface. Wheels are rotatably connected to the front platform and the driver platform, and a motor is in at least one of the wheels. The front platform and the driver platform are relatively rotatable between a stowed position in which the planar surfaces are in separate planes and a cargo position in which the planar surfaces are coplanar.
US10850788B2	Electric vehicle An electric self-balancing vehicle including a top cover, a bottom cover, an inner cover, a rotating mechanism, two wheels, two hub motors, a plurality of sensors, a power supply, and a controller is described herein. The top cover includes a first top cover and a second top cover disposed symmetrically and rotatable relative to each other. The bottom cover is fixed to the top cover and includes a first bottom cover and a second bottom cover disposed symmetrically and rotatable relative to each other. The inner cover is fixed between the top cover and the bottom cover and includes a first inner cover and a second inner cover disposed symmetrically and rotatable relative to each other. The rotating mechanism is fixed between the first inner cover and the second inner cover. The two wheels are rotatably fixed at two sides of the inner cover, respectively. The two hub motors are fixed in the two wheels, respectively. The plurality of sensors is disposed between the bottom cover and the inner cover, respectively. The power supply is fixed between the first bottom cover and the first inner cover. The controller is fixed between the second bottom cover and the second inner cover, the controller is electrically connected with the plurality of sensors, the power supply, and the hub motors, and the controller controls the hub motors to drive the corresponding wheels to rotate according to sensing signals transmitted by the sensors.
US10850787B2	System for fixing an accessory to a motorcycle or bicycle The present invention relates to a fixing system for fixing an accessory to a motorcycle or bicycle, comprising coupling means for coupling the accessory (1) to the motorcycle, and characterized in that said coupling means comprise a plurality of protrusions (2) placed in the motorcycle which are coupled with a plurality of complementary holes (3) of said accessory (1).The invention allows making the most of its use in different motorcycle models, and furthermore it neither impairs nor affects the appearance of the motorcycle when the bag is not placed in the use position.
US10850783B2	Foldable electric scooter and manufacture method of the same The present application relates to the field of electric scooter, and more particularly to a foldable electric scooter and a manufacture method of the same. Electric scooter 10 includes front wheel assembly 20, front fork assembly 30, headset assembly 50, handlebar assembly 60, throttle controller 70, gooseneck assembly 80, main body assembly 90, standing platform 100, drive train assembly 110, and rear wheel assembly 120. One purpose of the present application is to provide an electric scooter that has a flexible design, whose rear tire revolves inwardly and handlebar assembly collapses to minimize the whole volume of the electric scooter for facilitating transportation and storage. Another purpose of the present invention is to provide a method of manufacturing the electric scooter.
US10850782B2	Vehicle coupling lines storage and control arrangement A vehicle component actuation arrangement includes a vehicle component movable between a first configuration and a second configuration, an actuator configured to move the vehicle component between the first configuration and the second configuration, and a pneumatic valve arrangement pneumatically coupled to a vehicle air supply line, a vehicle pneumatic source and the actuator, where the valve arrangement is configured to move the vehicle component between the first and second configurations via the actuator when an air pressure is removed from within the vehicle air supply line.
US10850773B2	Chassis for a motor vehicle A chassis for a motor vehicle includes a longitudinal axis, at least one longitudinal member, and a front bumper fastened to the longitudinal member. The front bumper includes a region protruding over the longitudinal member in the lateral direction (y-direction). The chassis includes a support which has a transverse limb and a longitudinal limb. The longitudinal member has an outer face and the support is fastened at the transverse limb to the outer face of the longitudinal member. The transverse limb extends laterally to the outer face. The longitudinal limb adjoins the transverse limb laterally on the outside and extends in the longitudinal direction away from the front bumper.
US10850771B2	Camber adjusting assembly An apparatus and a method are provided for a camber adjustment assembly, comprising: first and second end plates coupled to a substantially planar center portion, wherein the first and second end plates comprise a generally triangular configuration; a chassis element coupled to a trailing arm and the camber adjustment assembly, and wherein a force may be applied to the camber adjustment assembly so as to desirably induce a positive or negative camber condition.
US10850770B2	Device and a method for reversing an articulated vehicle combination A device for reversing an articulated vehicle combination that has at least two vehicle units interconnected via at least one articulated join includes an arrangement for recording and storing a plurality of global positions of a local position of the vehicle combination, at least one sensor, mounted on the vehicle combination, for recording data representing a plurality properties of the surroundings, and a control unit arranged to determine, based at least partly on a plurality of dimensions of the vehicle combination, a set of global positions recorded when the vehicle combination is moving forward, and a set of data representing properties of the surroundings recorded during the forward movement, vehicle control input data for control of the vehicle combination during a reverse movement of the vehicle combination.
US10850767B2	Work vehicle and control method for work vehicle A work vehicle includes a hydraulic actuator, a hydraulic pump, an operation member, a control valve, an angular velocity corresponding value sensing unit, a notification component, and a controller. The actuator changes a steering angle based on a supplied fluid. The pump supplies fluid to the actuator. The operation member is operated by an operator when the steering angle is changed. The valve controls flow of fluid supplied from the pump to the actuator based on an amount the operation member is operated. The sensing unit senses a corresponding value corresponding to a steering angular velocity changed based on the flow of fluid. The notification component notifies that the corresponding value has reached a threshold value preset based on an upper limit of the steering angular velocity. The controller causes the notification component to perform a notification when it is detected that the corresponding value has reached the threshold value.
US10850765B2	Electric power steering system An electric power steering system is provided that is capable of performing assist control in which a change in a steering feel is reduced. The electric power steering system includes a current command value calculating unit configured to output a current command value Iref1 in accordance with steering torque and a vehicle speed on the basis of an assist map. The current command value calculating unit includes a vibration component reducing section configured to reduce a vibration component resulting from vibrations for warning that have been transmitted to a steering wheel and included in the steering torque.
US10850764B2	Ball screw device, method of manufacturing ball screw device, and steering system including ball screw device In a ball screw device, an inner peripheral rolling groove of a nut includes, between openings of mounting holes, a constant pitch circle diameter region where a pitch circle diameter is constant and gradually-changing pitch circle diameter regions where the pitch circle diameter gradually increases, in the ranges from opposite ends of the constant pitch circle diameter region to the respective openings. At least the constant pitch circle diameter region has a surface hardness greater than or equal to a predetermined value, among the constant pitch circle diameter region and the gradually-changing pitch circle diameter regions excluding edges at the boundaries between the respective openings and the inner peripheral rolling groove, and the edges at the boundaries between the respective openings and the inner peripheral rolling groove have a surface hardness less than the predetermined value.
US10850762B2	Steering device support structure for vehicle Provided is a steering device support structure having better collision performance and more excellent steering device vibration performance. The steering device support structure 10 for a vehicle comprises: a cross car beam 1 having a given axial direction and comprising a planar portion extending along the axial direction; a steering device support member attached to the cross car beam 1 to support a steering device; and a center stay 3 for supporting the cross car beam 1. The steering device support structure further comprises a reinforcing member 5 (5a, 5b) provided to the cross car beam to cover the planar portion 1b of the cross car beam, and fastened to the steering device support member 2.
US10850761B2	Industrial truck An industrial truck comprises a drive system and a steering arrangement. The steering arrangement comprises a steering column having a steering column portion extending along a steering column portion axis. A steering wheel is rotatably mounted on an end of the steering column portion, wherein the steering column portion is configured to adjust the steering wheel relative to a position of a driver. A control unit comprises a display module and is coupled to a portion of the steering column such that the control unit extends from the portion of the steering column along an axis that intersects with the axis of the steering column portion.
US10850750B2	Vehicle draft key wear protector Various embodiments include a vehicle draft key wear protector including a first arm, a second arm spaced-apart from the first arm, a first connector integrally connected to the first arm and integrally connected to the second arm, and a second connector integrally and detachably connected to the first arm and integrally and detachably connected to the second arm, wherein the railroad car draft key wear protector is configured to be positioned on an uninstalled draft key, and is configured to be positioned on an installed draft key in situ.
US10850741B2	Systems and methods for automated vehicle driving that mimic safe driver behaviors A system includes a pattern recognizing module that identifies a pattern based on at least one of: (i) a movement of a driver of a vehicle, (ii) an object in front of the vehicle, (iii) a status of the vehicle, and (iv) an action of the vehicle. The pattern corresponds to a pattern response. A safety module compares the pattern response to a safe maneuver database. The pattern response is classified as safe in response to the pattern response matching at least one safe pattern response of the safe maneuver database. A pattern integration module integrates the pattern and the pattern response into a pattern database in response to the pattern response matching the at least one safe pattern response of the safe maneuver database. A vehicle control module performs the pattern response in response to the pattern recognizing module identifying the pattern.
US10850736B2	Transmission control or steering control based on one or more operating inputs associated with a vehicle An example, described herein, involves monitoring an operating input of a vehicle; determining a turning maneuver is to be performed by the vehicle with a decreased turn radius based on the operating input; determining that a transmission of the vehicle is to be downshifted to a low gear to enable the vehicle to perform the turning maneuver; and downshifting the transmission to the low gear.
US10850733B2	Method for automatically adjusting the vehicle speed In a method for automatically adjusting the vehicle speed of a vehicle, while the distance to a preceding other vehicle is continuously measured, in order to reduce an initial distance, the vehicle is initially moved, in a drive phase, at a higher vehicle speed and is subsequently decelerated in a braking phase.
US10850731B2	Apparatus and method for automated traffic and driving pattern recognition and location-dependent measurement of absolute and/or relative risk probabilities for car accidents Proposed are a measuring apparatus (1) and a measuring method for automated traffic and driving pattern recognition and location-dependent measurement and forecast of absolute and relative risks for car accidents based on exclusively non-insurance related measuring data and based on automated traffic pattern recognition and associated with the traffic and driving pattern providing a high degree of temporal and spatial resolution. The proposed apparatus (1) provides a grid-based (2121, 2122, 2123, 2124), technically new way of automation of automated traffic and driving pattern recognition and risk-prediction related to motor accidents using environment based factors (elevation, road network, traffic data, weather conditions including socio-economic factors) that are impacting motor traffic and are location dependent received from appropriate measuring devices (41, . . . , 45). In this way, predictions of the accident risk for arbitrary areas can be provided. The measuring apparatus (1) is calibrated by comparing features of areas or road segments with the number and type of accidents that have measured or registered there, linking the features and accident data e.g. using the disclosed machine learning techniques.
US10850723B2	Self-propelled vehicles having a steering position sensor Self-propelled vehicles that include swiveling caster wheels and independent drive wheels are disclosed. The self-propelled vehicles are selectively steered in a caster wheel steering mode or a drive wheel steering mode. The vehicle includes a steering position sensor to measure the position of the steering system. A control unit varies the rotational speed of first and second drive wheels based at least in part of the signal from the steering position sensor.
US10850719B2	Anti-lock brake device The disclosure provides an anti-lock brake device including an oil pressure tank, a first piston and a second piston. The oil pressure tank has an internal space, an oil inlet and an oil outlet that are connected to one another. The first piston is slidably located in the internal space, and has a first oil channel penetrating a contact portion of the first piston and connected to the oil inlet. The second piston is slidably located in the internal space and includes a push portion, and an outer diameter of the push portion is smaller than that of the contact portion. When the second piston is in a closed position, a chamber having a first unoccupied volume is formed in the internal space. When the second piston is moved from the closed position to a depressurized position, the first volume of the chamber is increased to a second volume.
US10850717B2	Vehicle control device and vehicle control method A driving assistance apparatus determines, based on an instantaneous indicator which is an instantaneous value of a parameter regarding steering of the own vehicle, whether a driver has started a collision avoidance operation for avoiding a collision between a target and the own vehicle. When it is determined that the collision avoidance operation has been started, a support start timing for starting driving assistance for avoiding the collision between the target and the own vehicle or reducing collision damage is set to be a timing later than when the collision avoidance operation has not been started. The support start timing during a collision avoidance time period which is a time period until a predetermined set time has elapsed after it is determined that the collision avoidance operation has been started is set based on a time-dependent indicator for steering indicated by the instantaneous indicator at timings during the collision avoidance time period.
US10850716B2	System and method for controlling an automated braking application A controller comprises an electronic communication line configured to receive a system brake request control signal representing a requested system brake application and an identified urgency. A hardware processor, configured to perform a predefined set of basic operations in response to receiving the system brake request control signal, is capable of: determining a maximum braking pressure to be applied during the system braking application based on the identified urgency; generating a first system brake mode control signal, based on the determined maximum braking pressure, to set an associated first valve to a first valve state; generating a second system brake mode control signal, based on the determined maximum braking pressure, to set an associated second valve to a second valve state, the maximum braking pressure during the system braking application being set by the first valve state and the second valve state; determining an activation profile for an associated modulator based on the determined maximum braking pressure; the controller transmitting, via the electronic communication line, the first system brake mode control signal, the second system brake mode control signal and modulator control signals according to the activation profile.
US10850715B1	Towed vehicle braking system with battery voltage controlled operation A towed vehicle braking system is described that in some embodiments includes a brake pedal connector configured to connect to a brake pedal of a brake of a towed vehicle. A brake drive system is connected to the brake pedal connector to actuate the brake of the towed vehicle through the brake pedal connector by applying a positive pressure to the brake pedal connector to move the brake pedal. A voltage detector is coupled to a battery of the towed vehicle to detect the voltage at the battery and an ON/OFF circuit is coupled to the voltage detector to turn off the brake drive system in response to the detected voltage being above a predetermined voltage threshold.
US10850712B2	Systems and methods for refueling Methods and systems are provided for refilling a fuel tank devoid of fuel vapors. In one example, a method may include, prior to an upcoming refueling event, conditioning a fuel vapor-less fuel tank by operating a fuel pump. Operation of the fuel pump may agitate and vaporize the residual fuel in the fuel tank.
US10850708B2	In-vehicle control apparatus using smart key provided with display and method of controlling the same A user interface capable of controlling various functions in a vehicle is disclosed. The vehicle control method using a smart key includes an integrated operation unit detecting attachment of the smart key through a smart key detector disposed in a predetermined attachment area inside a vehicle, the integrated operation unit transmitting information on a controlled function corresponding to a vehicle state to the smart key, outputting a first user interface corresponding to the information on the controlled function on a first display of the smart key, transmitting information on a result of operation from the smart key to the integrated operation unit when an operation unit provided in the smart key is operated, and the integrated operation unit controlling the controlled function based on the information on the result. The smart key is fixed in the attachment area using magnetic force.
US10850698B2	Flexible vehicle door with airbag A side door for a motor vehicle is formed from a flexible material such as a fabric and has a chamber formed therein which houses an occupant protection side airbag or curtain airbag.
US10850696B2	Bumper assemblies and vehicles comprising same A bumper assembly having a transverse bumper body and at least one wing extension that is configured for pivotal movement relative to a side end of the transverse bumper body. Each wing extension has inner and outer surfaces and is moveable from a rest position to an impact position in response to an impact force acting within a horizontal plane. In the rest position, the outer surface of each wing extension is parallel or substantially parallel to the transverse axis, and in the impact position, the outer surface of the wing extension is positioned at an acute angle relative to the transverse axis. Each wing extension is configured to return to its rest position in response to removal of the impact force.
US10850695B2	Vehicle front structure and method of producing the same A vehicle front structure includes a crash box and an absorber. The crash box is provided between a front end of a front side member extending in a vehicle front-rear direction, and a bumper reinforcement extending in a vehicle width direction. The absorber is provided forward of the bumper reinforcement in the vehicle front-rear direction and extends in the vehicle width direction. In the vehicle width direction, an outer end of the crash box in the vehicle width direction is positioned outward of an outer end of the bumper reinforcement in the vehicle width direction, and in the vehicle width direction, an outer end of the absorber in the vehicle width direction is positioned outward of the outer end of the bumper reinforcement in the vehicle width direction.
US10850688B2	Vehicular circuit body A vehicular circuit body provided in a vehicle includes a trunk line that extends in at least a front-and-rear direction of the vehicle, a plurality of control boxes that are provided in the trunk line, and a branch line that directly or indirectly connects a control box to an accessory. The trunk line includes a power source line having a predetermined current capacity and a communication line having a predetermined communication capacity. The branch line includes a communication line having a predetermined communication capacity. The communication line of the trunk line has a transmission path for an optical signal. The communication line of the branch line has a transmission path for an electric signal.
US10850684B2	Vehicle secure messages based on a vehicle private key An example apparatus comprises a processing resource coupled to a memory resource. The processing resource may be configured to execute instructions stored on the memory resource to generate a first secure key including a private key stored by a vehicle, generate a first secure message including the first secure key, transmit the first secure message over a vehicle bus to a vehicle part associated with the vehicle, and receive, from the vehicle part, a second secure message including at least one of a vehicle identification number (VIN) and a configuration parameter corresponding to the vehicle part in response to a determination that the first secure key matches a secure key corresponding to the vehicle part.
US10850683B1	Electrical connections using vehicle brake lines An apparatus includes a first electrical component, a second electrical component, and a brake line. At least part of an electrical connection between the first electrical component and the second electrical component is defined by the brake line. The electrical connection may be a secondary electrical connection for rerouting an electrical path. The brake line may include first and second tubular conductive structures for defining first and second electrical connections. A repeater may be used to retransmit a data signal along the brake line. A nonconductive layer may be disposed on a tubular conductive structure of the brake line. A controller may switch operation of the brake line between an electrical power transmission mode and a data signal transmission mode. A controller may be operable determine a connected state or a disconnected state of the brake using the electrical connection.
US10850682B2	Interior member for vehicle An interior member for a vehicle includes: a base material formed of a resin; a front surface portion configured to constitute a portion of a design surface in a vehicle cabin and cover a surface of the base material that is on the design surface side; and a conductive portion integrally provided with the base material in a state where a portion of the conductive portion that is opposite to the design surface is in close contact with the base material and a portion of the conductive portion that is on the design surface side faces the front surface portion such that power is supplied to an electrical component installed in the vehicle through the conductive portion, the conductive portion being formed of a metal.
US10850680B2	Vehicle display apparatus and vehicle having the same A vehicle display apparatus that includes: a sensor unit that is configured to obtain a vehicle surrounding image and sense an appearance change of a vehicle; a display unit that is configured to display the vehicle surrounding image that includes a vehicle image showing at least a portion of a vehicle appearance; and a processor that is configured to: obtain, from the sensor unit, information on the appearance change of the vehicle, based on the information on the appearance change of the vehicle, generate the vehicle surrounding image to show the appearance change of the vehicle, and control the display unit to display the vehicle surrounding image is disclosed.
US10850677B2	Automatic securement pin system for a hitch connector An automatic securement pin system for a hitch connector includes a hitch bar having an insert end configured to be inserted into a hitch receiver, a securement pin coupled to the hitch bar, and an actuator coupled to the securement pin. The actuator is configured to engage the hitch receiver to displace the securement pin from an open position.
US10850675B2	Stowable roof rack for a vehicle A stowable roof rack for a roof of a motor vehicle includes a first roof rail connected to the roof of the motor vehicle, the first roof rail having a first exterior side facing outwardly relative to the motor vehicle and a first interior side facing inwardly relative to the motor vehicle, a second roof rail connected to the roof of the motor vehicle spaced apart from substantially parallel the first roof rail, the second roof rail having a second exterior side facing outwardly relative to the motor vehicle and a second interior side facing inwardly relative to the motor vehicle, and a crossbar moveable between a stowed position and a deployed position, wherein when in the stowed position the crossbar is connected at a first end to the interior surface of the first roof rail and at a second end to the interior surface of the first roof rail, and wherein when in the deployed position the crossbar is connected at the first end to the interior surface of the first roof rail and at the second end to the interior surface of the second roof rail.
US10850671B2	Apparatus and storage system for storing an article in a motor vehicle An apparatus is provided for holding an article in a motor vehicle. That apparatus includes a motor vehicle storage compartment having a receiver and a reversible insert held in the receiver. A storage system is also disclosed including a left-hand storage compartment including a first receiver, a right-hand storage compartment including a second receiver and a reversible insert configured for receipt in the first receiver and the second receiver.
US10850669B2	Trailer step assembly A trailer, retractable stair assembly, and method of operating same is provided. The trailer includes a frame that defines an interior cavity. A retractable stair assembly is movable between a stowed position in which the retractable stair assembly is positioned within the interior cavity and a deployed position in which the retractable stair assembly extends out of the trailer frame to establish a plurality of steps out of the trailer to an egress surface.
US10850668B2	Rear-view mirror for vehicle A rear-view mirror for a vehicle includes a body part, a mirror part, a display part, and an input member configured to control at least one of the body part or the display part, the input member configured to be selectively arranged in first, second, and third states. Based on the input member being in the first state, the body part is configured to be placed in a first position, and the display part is configured to turn on, based on the input member being in the second state, the body part is configured to be placed in a second position, and the display part is configured to turn on, and based on the input member being in the third state, the body part is configured to be placed in the second position, and the display part is configured to turn off.
US10850658B2	Tie down strap system A tie down strap system is provided. The system includes a first flexible strap, a first hook disposed on the first flexible strap, a pair of adjusters disposed on the first flexible strap on each side of the first hook, a first connector attached to a first end of the first flexible strap, and a second connector attached to a second end of the first flexible strap. The system may be used to secure an item, such as a two-wheeled vehicle, to an object, such as a bed of a tow vehicle.
US10850654B2	Cushioning for a seating or backrest portion of a motor vehicle seat The invention concerns a cushioning for seating or a backrest of a motor vehicle seat having a heating layer with an electric circuit made from conductive ink. The circuit has two buses extending longitudinally, the buses are connected together by a plurality of printed microcircuits shaped so as to form resistances capable of heating the cushioning. The cushioning also includes buses made from a first ink and microcircuits made from a second ink, the first ink having a higher intrinsic conductivity than that of the second ink, or the bus and microcircuits are made from the same ink, the ink being deposited more thickly for the buses than for the microcircuits, such that the buses provide minimized electrical resistance to the flow of current.
US10850653B2	Seat A car seat includes a first heater, a second heater, and a control unit which controls an output to the first heater and an output to the second heater. The control unit executes a temperature-difference adjustment control, in which the output of the second heater is controlled such that the temperature of the bulging portion heated by the second heater with respect to the temperature of the seating surface portion heated by the first heater is made lower when an ambient temperature is a first temperature than when the ambient temperature is a second temperature which is higher than the first temperature.
US10850648B2	Seat pan articulation mechanism An articulation mechanism for coupling a pivoting backrest to a traveling seat pan frame includes a first link having a first end section attachable to a pivoting backrest, and a second end section connected to the first end section, the second end section having multiple holes. A second link has a first end section and a second end section connected together, the first end section of the second link having at least one hole aligned with one of the multiple holes of the second section of the first link, the second end section of the second link is pivotally attachable to a seat pan frame. A fastener pivotally attaches the second link to the first link via the at least one hole of the second link and the selected aligned one of the multiple holes of the second end section of the first link based on a hole combination chosen to achieve a predetermined ratio of backrest recline to seat pan travel.
US10850646B2	Track assembly and carriage assembly for a vehicle A vehicle includes a carriage assembly and a track assembly. The carriage assembly includes a central roller flanked by side rollers on an axle. A carriage rail can support the axle. The track assembly includes a rack screw positioned in a lower portion of a channel. The channel receives the carriage assembly such that a drive wheel can engage with the rack screw.
US10850641B2	Seat for a vehicle A seat has a first seat element and a second seat element. In a first seat position of the seat, the first seat element forms a seat base of the seat and the second seat element forms at least part of a backrest of the seat. In a second seat position of the seat, the second seat element forms the seat base of the seat and the first seat element forms at least part of the backrest of the seat.
US10850635B2	Apparatus and method for providing charging information of electric vehicle For informing a user of a current battery SOC (State Of Charge) value (%) and a cost required for a full charging, an apparatus for providing charging information of an electric vehicle includes storage that stores chargeable capacity information of a battery mounted in the electric vehicle, a communication module that receives a charging fee schedule of a charging station, a controller area network (CAN) connection module that acquires charged amount information corresponding to a current SOC value of the battery, a controller that calculates an expected charging cost based on the chargeable capacity information of the battery, the charged amount information corresponding to the current SOC value of the battery, and the charging fee schedule, and a displaying assembly that displays the calculated expected charging cost and the current SOC value of the battery.
US10850633B2	Automated electric vehicle charging system and method A system and method for charging an electric vehicle includes identifying vehicle information corresponding to the electric vehicle based on an electronic image of the electric vehicle, retrieving from an electronically stored database a location of a charging port on the electric vehicle based on the vehicle information, and robotically moving a charging connector according to the retrieved location to engage the charging port of the electric vehicle to charge a battery.
US10850632B2	Power supply system for vehicle, and control method of power supply system A power supply system for a vehicle includes: a main power supply; an electric power converter including a capacitor; a relay; a sub power supply; a boost converter; a cooler; and a controller configured to cause the sub power supply and the boost converter to precharge the capacitor, when a main switch of the vehicle is turned on and before the relay is closed to connect the electric power converter to the main power supply. The controller is configured to perform one of a control i) and a control ii) when one of a temperature of the boost converter and a temperature of a coolant in the cooler is higher than a specified temperature threshold. The control i) being a control to start the precharging while starting up the cooler. The control ii) being a control to start up the cooler before the precharging.
US10850629B2	Systems and methods for integration of electric vehicle charging stations with photovoltaic, wind, hydro, thermal and other alternative energy generation equipment In accordance with one aspect of the embodiments described herein, there are provided systems and methods for integration of electric vehicle charging stations with photovoltaic, wind, hydro, thermal and other alternative energy generation equipment. In various embodiments, the aforesaid integration is used to perform balancing of the electrical power generated by the aforesaid photovoltaic, wind, hydro, thermal and other alternative energy generation equipment and the electrical power consumed by the aforesaid EVSE equipment. In one exemplary embodiment, the aforesaid balancing may be performed on a house (building) level. In another exemplary embodiment, the balancing may be performed on a neighborhood level.
US10850622B2	Electric travelling vehicle and grass mower An electric travelling vehicle including: a motor controller configured to control an electric motor based on displacement of a steering operation part to a forward travel position, a neutral position, and a rearward travel position, a brake controller configured to bring an electromagnetic power-off brake into a released state or a braking state; and a travel state detector configured to detect a travelling state that is accompanied with the released state, a stopped state that is accompanied with the braking state, and a transit stopped state that is accompanied with the braking state.
US10850615B2	Vehicle display including a camera An illustrative example assembly includes a display having a first side for displaying at least one image and a second side facing opposite the first side. The display includes a first portion having a first plurality of layers between the first side and the second side. The display includes a second portion having a second plurality of layers between the first side and the second side. The second plurality of layers includes at least one additional layer more than the first plurality of layers. A camera is situated near the second side of the display with a field of view of the camera at least partially aligned with the first portion of the display.
US10850609B2	Solenoid assembly for a valve A fuel tank isolation valve (FTIV) is provided, configured for being disposed in fluid flow communication with a fuel tank and a carbon canister of a fuel system, the FTIV including an integrated controller and a solenoid coupled to a valve, the solenoid being movable between a normally closed position in which the valve is closed and prevents fluid communication through a first flowpath through the FTIV, and an open position in which the valve is open and allows for fluid communication through the first flowpath, the integrated controller being configured for generating actuation signals to the solenoid, responsive to parameter signals received from one or more sensors associated with the fuel tank. A sensing system for use with a fuel system is also provided, the sensing system including the FTIV and at least one such sensor. A fuel system is also provided, including a fuel tank and a carbon canister, and also including the sensing system for use therewith.
US10850607B2	Fuel tank device of vehicle A fuel tank device of a vehicle includes a fuel supply pipe, a first fuel tank, a second fuel tank, and a resistance portion. The fuel supply pipe includes a main pipe, and a first branch pipe and a second branch pipe that branch from the main pipe. The first fuel tank is connected to the first branch pipe, the second fuel tank is connected to the second branch pipe, and the resistance portion is provided in the main pipe and is configured to impart resistance to liquid fuel flowing in the main pipe.
US10850601B2	Series-hybrid electromechanical compound transmission device for tracked vehicle The present invention discloses an electromechanical compound transmission device for a tracked vehicle. The electromechanical compound transmission device includes a front transmission mechanism, a power coupling mechanism, an independent drive mechanism, and convergent planetary gearsets arranged on both sides of the power coupling mechanism. The present invention can not only implement driving, steering, and other functions of a vehicle, but also provide sufficient electric energy for a vehicle-mounted device. In other words, a series mode can be adopted to satisfy a torque output requirement, and is mainly used for low and medium-low speed driving, as well as reverse driving and climbing steep slopes; and a series-parallel mode can also be adopted to satisfy requirements of high and medium-high speed driving, and can achieve relatively high transmission efficiency and fuel economy.
US10850599B2	Power-driven system for vehicle and vehicle The present disclosure provides a power-drive system for a vehicle and a vehicle. The power-drive system comprises: an engine; a plurality of input shafts, the engine being configured to selectively engage with at least one of the plurality of input shafts; a plurality of output shafts; a first motor power shaft, a motor power shaft first gear being arranged on the first motor power shaft, the motor power shaft first gear and the plurality of output shafts linking with a differential of the vehicle respectively; a second motor power shaft, a motor power shaft second gear linking with one gear-position driven gear being arranged on the second motor power shaft; a transfer gear, configured to selectively engage with the motor power shaft first gear to link with the motor power shaft first gear, and selectively engage with the motor power shaft second gear to link with the motor power shaft second gear; and a first motor generator, configured to link with the transfer gear.
US10850596B2	Fuel cell system for motor vehicle and control method of same A fuel cell system includes a fuel cell stack configured to supply power to an electric motor for driving a vehicle as well as generating power by an electrochemical reaction between a fuel gas and an oxidant gas, a discharge circuit and the discharge control circuit. The discharge circuit may form a plurality of discharge paths through which power generated in the fuel cell stack is discharged switching elements switching the connection relationships between resistance elements. The discharge control circuit form a second discharge path whose resistance value is smaller than the resistance value of the first discharge path and to switch the discharge through a first discharge path to discharge through the second discharge path when the detected voltage that is detected by the voltage detection unit is lower than a predetermined threshold voltage during the discharge through the first discharge path.
US10850595B2	Vehicular sensing system with attenuation of reflected-refracted light off of precipitation using light polarization A sensing system for a vehicle includes a sensor disposed at a vehicle and a control that includes a processor for processing sensor data captured by the sensor. A first polarizer is disposed in a light emitting path of at least one light source of the vehicle and a second polarizer is disposed in a light receiving path of the sensor. The second polarizer has an opposite-handed polarization configuration relative to the first polarizer. Some of the polarized light as polarized by the first polarizer impinges precipitation present in the field of sensing of the sensor and returns toward the sensor as refracted-reflected light. The second polarizer attenuates the refracted-reflected light and allows light reflected from objects present in the sensor's field of sensing to pass through to the sensor. The control, responsive to processing of captured sensor data, detects objects in the field of sensing of the sensor.
US10850593B2	Flap-retaining clip for a pressure relief assembly A pressure relief assembly includes a housing defining an air passage chamber having at least one opening, and a membrane flap secured within the air passage chamber. The membrane flap is configured to move into an open position to expose the opening(s) to relieve air pressure. A plurality of flap-retaining clips securely couple the membrane flap to the housing. Each of the plurality of the flap-retaining clips includes a main body. A housing-connecting tab extends from a first end of the main body. The housing-connecting tab is retained within a retaining channel formed in the housing. Opposed flap-retention wings laterally extend from opposite sides of the main body. A portion of the membrane flap is trapped between the opposed flap-retention wings and the housing to securely couple the membrane flap to the housing.
US10850588B2	Automated passenger counter systems and methods APC systems and methods using vehicle mass to assess boardings and alightings of passengers on transit vehicles (e.g., buses). Vehicle mass is determined based on signaled information indicative of a pressure in one or more air bag circuits of an air ride suspension system of the vehicle. In some embodiments, pressure information from three air bag circuits of the vehicle are monitored and reviewed to determine vehicle mass. The passenger count can be estimated based on determined vehicle mass by an Additional Mass Method or an Event-Based Method for example.
US10850586B2	Anti-roll moment distribution active suspension A system for controlling a suspension of a vehicle includes a plurality of sensors, an anti-roll moment module configured to determine a front-to-total anti-roll moment distribution based on at least a first operating parameter of the vehicle, at least one suspension actuator, and a suspension control module configured to control the at least one suspension actuator based on the determined front-to-total anti-roll moment distribution. A method of producing an anti-roll moment distribution module for a vehicle includes determining understeer characteristics of the vehicle, determining a maximum lateral acceleration of the vehicle, adjusting the understeer characteristics based on the determined maximum lateral acceleration, determining reference understeer characteristics, determining a plurality of reference yaw rates and a plurality of feedforward contributions using a non-linear quasi-static model of the vehicle, storing the reference yaw rates in a first look-up table, and storing the feedforward contributions in a second look-up table.
US10850584B2	Damper housing and a method for manufacturing the damper housing A damper housing disposed on a center axis includes an extended mains section and a narrowed end section. The narrowed end section has a second predetermined wall thickness less than the first predetermined wall thickness of the extended main section. An intermediate conical section, connecting the narrowed end section and the extended main section, has an intermediate conical section wall thickness equal to the second predetermined wall thickness at an internal inclination angle relative to the center axis. A method for manufacturing the damper housing using a preformed tube, a first broaching die, a calibrating mandrel, and a swaging die is performed by compressing the preformed tube between the first broaching die and the narrowed head of the calibrating mandrel and compressing the preformed tube between the swaging die and the intermediary section of the calibrating mandrel to form the narrowed end section and the intermediate conical section, respectively.
US10850582B2	Rear suspension assembly for an off-road vehicle A vehicle has a frame, seats, two front and two rear suspension assemblies, two front and two rear wheels, and a motor. Each rear suspension assembly has a trailing arm, a knuckle pivotally connected to the trailing arm, a lower link having laterally outward and inward ends pivotally connected to the trailing arm at a first connection point and to the frame at a second connection point respectively, an upper link having laterally outward and inward ends pivotally connected to the trailing arm at a third connection point and to the frame at a fourth connection point respectively, and a toe link having laterally outward an inward ends pivotally connected to the knuckle at a fifth connection point and to the frame at a sixth connection point respectively. The fifth connection point is laterally further from a longitudinally and vertically extending center plane than the first and third connection points.
US10850580B2	Removable safety chain tie down apparatus A tie down apparatus that may be utilized for securing an item, such as a safety chain, wherein the tie down apparatus may be used with a hitch mounting system. In one embodiment, the tie down apparatus may include a receiving member, a tie down member, and a clocking member. The receiving member may include an opening located there through. The tie down member may include at least one aperture, wherein the tie down member may be capable of being located and rotated within the receiving member. The tie down member may be rotated either clockwise or counterclockwise. The locking member may include at least one leg capable of being housed within the aperture. The locking member may engage the receiving member once the tie down member is rotated, thereby trapping the item within the tie down apparatus.
US10850579B2	Pneumatic tire and structure for securing electronic part to tire A structure for securing an electronic part to a tire, has a sheet for securing the electronic part which is arranged between the sheet and a tire inner surface; and cushioning material which is arranged about a periphery of the electronic part and which adheres to the sheet and the tire inner surface. The cushioning material is not arranged on the tire inner surface where the electronic part is present but surrounds the electronic part completely or surrounds the electronic part except for at least one gap smaller than the electronic part.
US10850577B2	Tire comprising a passive transponder and method for reading the data A pneumatic tire has a passive transponder incorporated therein that allows communication with a radio-frequency reader located outside the pneumatic tire. The passive transponder includes at least one radiating antenna and is embedded in an electrically insulating elastomeric blend to form a patch. The patch extends axially between an axially inner end of a carcass ply of the pneumatic tire and an inner surface of the pneumatic tire. The patch also extends radially at a distance between a bead toe of the pneumatic tire and a radially outer end of a bead core of the pneumatic tire.
US10850576B2	Inflation system The inflation system includes a pump and a dehumidifier fluidly connected between the pump and a reservoir, such as a tire.
US10850575B2	Pneumatic tire Provided is a pneumatic tire in which a sealant layer entirely exhibits sufficient sealing performance. The present invention relates to a pneumatic tire including a sealant layer located radially inside an innerliner, the sealant layer being formed by continuously and spirally applying a generally string-shaped sealant to the inner periphery of a tire in the tire width direction from one side to the other, the attachment start portion of the sealant being located tire-widthwise inward from the tire-widthwise end of the sealant layer.
US10850574B2	Pneumatic tire A pneumatic tire includes: a rim cushion rubber disposed in a bead portion where the bead portion and a rim are in contact with each other; an electrically conductive rubber disposed in the rim cushion rubber, the electrically conductive rubber having an electrical resistance value lower than that of the rim cushion rubber, and including a first end exposed on an outer surface of the rim cushion rubber in contact with the rim, and a second end disposed in contact with a tire component adjacent to the rim cushion rubber; and an ground tread rubber disposed in a tread portion passing through a cap tread rubber and an undertread rubber of the tread portion, the ground tread rubber having an electrical resistance value lower than that of the cap tread rubber.
US10850573B2	Pneumatic tire A pneumatic tire comprises a plurality of protrusion portions extending along a tire side surface of a tire side portion in a direction that intersects a tire circumferential direction and a tire radial direction; the plurality of protrusion portions each including an intermediate portion in an extension direction that includes a highest position of projection height from the tire side surface, and tip portions on either side of the intermediate portion in the extension direction that include a lowest position of projection height from the tire side surface; and at least the intermediate portion being only disposed outward of a tire maximum width position in the tire radial direction.
US10850572B2	Tire A tire including a pattern region and plural unit patterns. The pattern region is formed at an outer surface of a tire and includes a base. The plural unit patterns are formed within the pattern region, and each unit pattern is formed including extension portions having a projection height from the base of from 0.1 mm to 1.0 mm. The extension portions extend in plural directions from a bend point in plan view. A spacing between the bend points of adjacent unit patterns out of the unit patterns is from 0.2 mm to 1.0 mm.
US10850571B2	Apparatus and method for detecting mileage of tyre An apparatus and method for detecting the mileage of a tyre. The apparatus includes a tyre state detector (100) and a data processor (200). The tyre state detector (100) is configured to detect and send a first identity identifier and state detection parameters of the tyre state detector (100) to the data processor (200); and the data processor (200) is configured to obtain a second identity identifier of the tyre and usage scenario information of the tyre and determine mileage data of the tyre, so as to generate and send tyre mileage detection information corresponding to the tyre. By determining the mileage data of the tyre, and establishing a correspondence relation so as to generate and send the tyre mileage detection information corresponding to the tyre, the detection of the mileage of the tyre can be realized, thereby realizing the intelligent management of the tyre.
US10850569B2	Pneumatic tire A shoulder lateral groove 5 comprises an inner lateral groove portion 7 intersecting a shoulder main groove 3S, an outer lateral groove portion 8 intersecting a tread edge (Te), and a sipe portion 9 connecting between the inner lateral groove portion 7 and the outer lateral groove portion 8. The outer lateral groove portion 8 has a bent portion 10 and extends so as to connect between the tread edge (Te) and the sipe portion 9.
US10850565B2	Pneumatic tire A pneumatic tire includes a tread portion, sidewall portions, bead portions, and has at least one carcass layer disposed between the pair of bead portions. The ratio SW/OD between the total tire width SW and the tire external diameter OD satisfies the relationship SW/OD≤0.3. A first region A is defined between a pair of first boundary lines (L1, L1), second regions B are defined between a first boundary line (L1) and a second boundary line (L2), and third regions C are defined on the bead toe side of the second boundary lines (L2). Defining SA, SB, and SC as the cross-sectional area (mm2) of the first region A to the third region C, and defining the peripheral lengths (mm) of the first region A to third region C along the tire inner surface as a, b, and c, respectively, the relationship 7.5≤SA/a≤11.5 is satisfied.
US10850563B2	Pneumatic tire Provided is a pneumatic tire having excellent chipping resistance. The present invention relates to a pneumatic tire formed from a rubber composition, the rubber composition having an elongation at break of 540% or higher as measured under the following test conditions: Tensile rate: 8.3 m/sec, Temperature: 75° C., Specimen: No. 3 dumbbell.
US10850561B2	Bicycle wheel securing device A bicycle wheel securing device comprises a shaft, an axial abutment structure, a bicycle-body engaging structure, a manual actuator, and a shaft-end retaining structure. The shaft has a first shaft end, a second shaft end, and a longitudinal center axis. The manual actuator is operatively connected to the axial abutment structure to bias the axial abutment structure against a first wheel attachment part of a bicycle body in response to operation of the manual actuator in a securing state where the bicycle-body engaging structure is engaged with a second wheel attachment part of the bicycle body. The shaft-end retaining structure is at least partly disposed at the second shaft end to retain the second shaft end in the first wheel attachment part in a maintenance state where the second shaft end is positioned in the first wheel attachment part of the bicycle body.
US10850560B2	Axle end assembly comprising a wheel hub unit and a wheel brake An axle end assembly has a wheel brake arrangement and a wheel hub arrangement. The assembly is designed as a preassembled unit with a hollow shaft element on which the wheel brake arrangement and the wheel hub arrangement are disposed.
US10850551B2	Multi-layer body and method for the production thereof A method for producing a multi-layer body, in particular a security element, in which a partial first layer or partial first layer system is produced on a substrate, wherein the partial first layer or partial first layer system is present in a first partial area and not in a second partial area. Subsequently, a partial second layer or partial second layer system is produced, wherein the partial second layer or partial second layer system is present in a third partial area and not in a fourth partial area, and wherein the third partial area overlaps with the first and second partial areas. Finally, the partial first layer or partial first layer system is structured as a mask using the partial second layer or partial second layer system.
US10850547B2	Polyester film and method of manufacturing polyester film Provided are a polyester film and a method of manufacturing the polyester film. A polyester film has a base film and at least one image receiving layer which is disposed on at least one surface of the base film, the base film contains a polyester and titanium oxide particles, the mass-based content of the titanium oxide particles in the base film satisfies Formula 1 on the assumption that the thickness of the base film is T μm, a surface roughness standard deviation Rq is 0.01 μm to 0.12 μm, a cross section in a thickness direction orthogonal to a plane direction of the base film has voids whose average area per void is 0.01 μm2/void to 0.10 μm2/void, and a surface roughness standard deviation Rq of an outermost surface of the image receiving layer is 0.01 μm to 0.1 μm.
US10850546B2	Heat-sensitive recording material A heat-sensitive recording material having i) a carrier substrate and ii) a heat-sensitive recording layer. The heat-sensitive recording layer contains a color former and a color developer mixture and the color developer mixture contains a) N/-[2-(3-phenylureido)phenyl]benzole sulfonamide (compound of formula (I)). The compound of formula (I) is present in a crystalline form, which has an absorption band in the IR spectrum at 3401±20 cm−1, and b) N-(4-methylphenylsulfonyl)-N-(3-(4-methylphenylsulfonyloxy)phenyl)urea (compound of formula (II)).
US10850539B2	Printing system, printing apparatus, and printing control method A printing apparatus has an array of printing elements, a unit for conveying a print medium in a direction intersecting with the array direction, a unit for setting the conveying speed, a unit for adjusting a print position of the print head in the array direction, a unit for adjusting an inclination of a print position of the print head with respect to the conveying direction and for dividing the array of the printing elements into blocks and shift image data in the conveying direction in each divided block, and a unit for changing the division positions of the blocks to positions shifted by an equal amount in a direction opposite to the adjustment in the array direction. A printing control apparatus acquires a maximum concurrent drive number in the printing elements based on image data. The conveying speed is set based on the maximum concurrent drive number.
US10850536B2	Liquid discharge apparatus, method of forming image, and recording medium A liquid discharge apparatus includes a liquid discharger, a curing device, a multi-scanning device, and processing circuitry. The multi-scanning device causes the discharger to relatively scan a non-permeable recording medium multiple times in each of two intersecting directions to form an image that includes pixels with different discharge amounts of an active energy ray curable liquid in a region of the medium. The circuitry generates thinned image data for forming the image for each relative scanning in a first direction, using a mask in which pixels allowing image formation are arrayed. The circuitry generates the thinned data such that a spatial frequency of an array of the pixels allowing image formation in the mask for a first discharge amount is uniform in relative scanning in a second direction and the spatial frequency for a second discharge amount decreases toward a downstream side in the relative scanning in the second direction.
US10850534B2	Image processing apparatus, image processing method, program, and ink jet printing system Provided are an image processing apparatus, an image processing method, a program, and an ink jet printing system that can perform image formation capable of improving texture and preventing bleeding in a case in which printing is performed on cloth. An image processing apparatus 12 acquires base material information 42 including at least information indicating the quality of fiber in cloth which is a medium to be printed and image data 40 of a pattern to be printed on the cloth and generates a pretreatment liquid image 44 that indicates a pretreatment liquid application pattern defining a pretreatment liquid application position where a pretreatment liquid including a functional material for preventing wetting and spreading of ink in the cloth is applied and a pretreatment liquid non-application position where the application of the pretreatment liquid is limited, on the basis of the base material information 42 and the image data 40.
US10850530B2	Printhead liquid delivery and gas removal In one example, a liquid delivery and gas removal system for a printhead. The system includes a pump to provide a liquid at a positive pressure. The system also includes a filter fluidically coupled to the pump to receive the pressurized liquid at an upstream side, at a first pressure push the liquid through the filter to a downstream side, and at a higher second pressure push gas bubbles in the liquid through the filter to the downstream side. The system further includes a vent having a gas-permeable membrane. A wet side of the membrane is fluidically coupled to the downstream side and to a printhead. A vacuum is applied to a dry side of the membrane.
US10850523B2	Image forming apparatus including cartridge having first storage chamber, cartridge attachment portion having second storage chamber, and recording portion For an image forming apparatus including first and second storage chambers, an inequality expression of “R2>A×R1” is met. R1 is a sum of a passage resistance value obtained by flowing air through a first air communication portion and a passage resistance value obtained by flowing liquid through a supply portion. R2 is a passage resistance value obtained by flowing air through a second air communication portion. A is a cross-sectional area ratio obtained by dividing a first average cross-sectional area of a first space of the first storage chamber taken along a plurality of horizontal planes by a second average cross-sectional area of a second space of the second storage chamber taken along the plurality of horizontal planes. The first space contains at least a portion adjacent to the supply portion and accumulating the liquid. The second space contains at least a portion accumulating the liquid.
US10850521B2	Ink storage unit having variable volume reservoirs Herein is disclosed an ink storage unit. The ink storage unit may comprise first and second reservoirs, each having a variable internal volume; a transfer system to transfer ink between the first and second reservoirs such that as ink is transferred from the first reservoir to the second reservoir, the internal volume of the first reservoir decreases and the internal volume of the second reservoir increases.
US10850515B2	Liquid ejecting head and liquid ejecting apparatus A liquid ejecting head including a plurality of pressure chambers in communication with nozzles that eject a liquid, a diaphragm that includes layers including a first layer and a second layer and that constitutes wall surfaces of the plurality of pressure chambers, a plurality of piezoelectric elements formed on a first region of the diaphragm, the piezoelectric elements each being formed to correspond to a corresponding one of the pressure chambers, and a barrier layer that is in contact with an interface between the first layer and the second layer in a second region of the diaphragm, the second region surrounding the first region.
US10850513B2	Liquid ejection head and liquid ejection apparatus A liquid ejection head includes a first pressure chamber row having a plurality of first pressure chambers respectively communicating with a plurality of ejection orifices that eject liquid and arranged along a predetermined direction, a second pressure chamber row having a plurality of second pressure chambers respectively communicating with a plurality of ejection orifices that eject liquid and arranged along the predetermined direction, a first flow path for supplying the liquid to the plurality of first pressure chambers, and a second flow path for recovering the liquid from the plurality of second pressure chambers. Part of the first pressure chamber row is disposed to overlap the first flow path, and part of the second pressure chamber row is disposed to overlap the second flow path, as viewed from an ejection direction of the liquid.
US10850512B2	Ink jet recording head and method of manufacturing same Provided is an ink jet recording head having a flow path member. The flow path member is made of a thermoset product of a thermosetting molding composition containing a solid epoxy resin composition containing an epoxy resin and a phenolic resin, each solid at ordinary temperatures, and an alumina filler.
US10850509B2	On-die actuator evaluation with pre-charged thresholds A fluid ejection die includes a number of actuator sensors to sense a characteristic of a corresponding actuator and to output a first voltage corresponding to the sensed characteristic. Multiple coupled actuator sensors and actuators are grouped as primitives on the fluid ejection die. The die also includes a pre-charge device per primitive to pre-charge a corresponding threshold voltage storage device to a threshold voltage. The die also includes an actuator evaluation die per primitive to evaluate an actuator characteristic of any actuator within the primitive.
US10850508B2	Modulation of vortex oscillations in inkjet system using synthetic jets A print assembly includes: a printhead having a plurality of inkjet nozzle devices; and an array of synthetic jet devices configured to provide a jet flow in a vicinity of ink droplets ejected by the inkjet nozzles.
US10850506B2	Drive bubble evaluation In some examples, a fluid ejection system can include one or more drive bubble devices and a sensor for each drive bubble device of the one or more drive bubble devices to detect a characteristic of each drive bubble device. The fluid ejection system can also include a controller. The controller can be configured to evaluate a first drive bubble device of the one or more drive bubble devices, and during the evaluation of the first drive bubble device, utilize one or more other drive bubble devices of the one or more drive bubble devices.
US10850503B2	Print head driving apparatus and printing apparatus having the same Disclosed is a print head driving apparatus including: a print head unit having a plurality of heater resistors arranged therein, the plurality of heater resistors being divided into sub groups; a counter configured to sequentially generate code signals corresponding to the sub groups, using a driving clock signal; a driving signal generation unit configured to generate a driving signal for the heater resistors included in each of the sub groups, using the code signal; and a head control unit configured to extract heater resistors to which the driving signal is inputted, among heater resistors corresponding to input image data, and drive the extracted heater resistors.
US10850496B2	Chemical-free production of graphene-reinforced inorganic matrix composites Provided is a simple, fast, scalable, and environmentally benign method of producing a graphene-reinforced inorganic matrix composite directly from a graphitic material, the method comprising: (a) mixing multiple particles of a graphitic material and multiple particles of an inorganic solid carrier material to form a mixture in an impacting chamber of an energy impacting apparatus; (b) operating the energy impacting apparatus with a frequency and an intensity for a length of time sufficient for peeling off graphene sheets from the graphitic material and transferring the graphene sheets to surfaces of solid inorganic carrier material particles to produce graphene coated or graphene-embedded inorganic particles inside the impacting chamber; and (c) forming graphene-coated or graphene-embedded inorganic particles into the graphene-reinforced inorganic matrix composite. Also provided is a mass of the graphene-coated or graphene-embedded inorganic particles produced by this method.
US10850493B2	Apparatus for three-dimensionally printing reactive materials Apparatuses are disclosed for three-dimensionally printing reactive materials which utilize a powder spreading step followed by a binder-jet deposition step. Some such apparatuses include a binder jet three-dimensional printing device, a curing device, and a depowdering device contained within an environmental enclosure which provides an inert atmosphere sufficient to allow a reactive material to be used as a build material without fire or explosion hazards. Some such apparatuses include one or more conveying systems for moving a removable build box among the various devices. Environmental enclosures having unique designs and features are disclosed.
US10850485B2	Polyester resin composition and production method thereof A polyester resin composition including an ionic liquid that can dissolve an acid component monomer and/or oligomers of a polyester terephthalate, and a copper element that exhibits a reduced amount of production of the acid component monomer and/or oligomers of the polyester. Examples of the ionic liquid include 1-butyl-3-methylimidazolium acetate, 1-butyl-3-methylimidazolium chloride and tetrabutyl ammonium bromide. In one polyester resin composition, the surface roughness Ra of a capture plate is less than 0.150 μm, as measured when a sample of the polyester resin composition is melt at 300° C. for 60 minutes under a nitrogen atmosphere, quickly cooled and thermally treated at 220° C. for 8 hours to form scattered products which are then attached to the capture plate and a gelation ratio after a 6-hour melting treatment at 300° C. under an atmosphere with an oxygen concentration of 1% is 5% or less.
US10850484B2	Multilayer films and methods of making the same Disclosed are multilayer films which can provide desired film performance suited for packaging applications favoring cost-effectiveness.
US10850483B2	Barrier tape for seaming and repair of barrier sheets A barrier tape comprises a barrier section comprising one or more barrier layers and one or more adhesive layers adhered to a face of the barrier section. The barrier tape can be used to join together adjacent barrier sheets or to patch a breach in a barrier sheet to form a barrier assembly.
US10850480B2	Closed container, in particular a foodstuff container, having a shaping coefficient The invention relates to a closed container, delimiting an interior from an exterior, wherein the closed container comprises a sheetlike composite; wherein the sheetlike composite comprises a layer sequence, comprising as mutually superposed layers in a direction from an. inner face of the sheetlike composite to an outer face of the sheetlike composite a) an inner polymer layer, b) a barrier layer, and c) a carrier layer; wherein the closed container is characterised by a shaping coefficient, determined according to the method described herein, in the range from 1.0 to 10.0 m2/kg. Further, the invention relates to a method by which a closed container with a shaping coefficient is obtainable; to the closed container obtainable by this method; to an apparatus, designed for producing one of the afore¬ mentioned closed containers; to a use of a sheetlike composite for producing one of the afore¬ mentioned closed containers; and to a use of one of the aforementioned closed containers for storing a foodstuff.
US10850474B2	Large cell carbon core sandwich panel and method of manufacturing same A method of fabricating a panel includes laying up a first laminate on a tooling surface, laying a first layer of thermoplastic on an inner surface of the first laminate, laying a large cell carbon core on the first layer of thermoplastic, laying a second layer of thermoplastic across the large cell carbon core, laying a second laminate on the second layer of thermoplastic, creating a sealed core pocket by bonding the edges of the first and second layers of the thermoplastic surrounding a perimeter of the core, increasing pressure within the core pocket, increasing pressure on the outer surface of the second laminate, heating the panel to a desired curing temperature, and maintaining the increased pressures and temperature for a desired curing duration.
US10850472B2	Soundproofing material To provide a means capable of exhibiting high soundproofing performance over a wide range of a frequency range of 2000 Hz or less.A soundproofing material includes a sheet having elasticity and a support portion partitioning the sheet into partition portions while holding the sheet, in which a surface rigidity (k) and a surface density (m) of the sheet in the partition portion are configured to satisfy a relationship of the following Expression 1. 1 2 ⁢ π ⁢ k m > 900 ⁢ [ Hz ] [ Expression ⁢ ⁢ 1 ]
US10850463B2	Method for fabricating spectacle frame made of cellulose acetate sheet embedded with metal piece A method for fabricating a spectacle frame made of a cellulose acetate sheet embedded with the metal piece, where the metal piece is embedded between a main material and auxiliary materials; the metal piece, the main material, and the auxiliary materials are tightly bonded by pressing by a hydraulic press. Since the metal piece is not in contact with a human body, there will be no corrosion problems. The composite plate structure resulting from splicing of the main material and the auxiliary materials have better mechanical performance.
US10850458B1	Method of forming a container insert for use in a closed loop dispensing system A container insert is disclosed for use with a closed loop dispensing system. The container insert is press-fitted into the throat of a liquid container. The container insert is comprised of a plastic substrate portion and an over-molded portion. This invention is directed to the method of simultaneously molding the plastic substrate portion and the over-molded portion.
US10850457B2	Actuatable flow media An actuatable flow media for the control of a flow rate of a liquid through the flow media, the actuatable flow media comprising a base having at least one cavity formed therein, at least one aperture formed in the cavity defining a liquid flow path for the entry of liquid into or exit of liquid from the flow media; a flexible membrane arranged in spaced relation with the base and defining a liquid flow path through the flow media; and an elastically deformable element arranged in the cavity and extending between the base and the flexible membrane for actuation between at least a first configuration in which the element is substantially undeformed and the liquid flow path through the at least one aperture is open and a second configuration in which the element is substantially deformed and the liquid flow path through the at least one aperture is closed.
US10850455B2	Automated fiber placement roller An automated fiber placement roller includes a metallic rim member arranged about a central axis and having an inner side and an outer side. The central axis is closer to the inner side than to the outer side, and the inner side defines a plurality of grooves enabling elastic deformation of the metallic rim member responsive to a force applied to the outer side. The automated fiber placement roller also includes a metallic hub member arranged substantially concentric with the metallic rim member about the central axis. The metallic hub member defines an opening to receive a shaft of an automated fiber placement machine. The automated fiber placement roller further includes a plurality of curved metallic interconnect members extending between the metallic hub member and the metallic rim member. Each of the plurality of curved metallic interconnect members is elastically deformable responsive to the force applied to the outer side.
US10850452B2	Apparatus and method for edge sealing of foam boards A method and machine for sealing at least one cut edge of a foam board is disclosed. The foam board has a top surface, a bottom surface and at least one cut edge extending between the top surface and the bottom surface. The cut edge is passed over a heated roller to soften the edge and then passed over a second roller having a temperature that is lower than the temperature of the first roller which seals the edge. The cut edge may be milled to square the edge relative to the top and bottom of the board before the cut edge is passed over the heated roller. Additional pairs of rollers may be provided to seal the top surface and the bottom surface of the foam board.
US10850447B2	Build material container Certain examples of a build material container for a three-dimensional printing system is described. The build material container has an external casing and an internal compartment within the external casing. The internal compartment may have a reservoir to store build material, where the reservoir has a channel structure, and a surround that encloses the reservoir. A partition is provided within which the channel structure is mounted, the partition forming an upper surface of the internal compartment and being independent from the external casing and the surround. The partition restricts access to the internal compartment and collects build material during use of the channel structure.
US10850445B2	Additive manufacturing system configured for sheet-printing composite material A head is disclosed for use with an additive manufacturing system. The head may include a housing, and a matrix reservoir disposed inside of the housing. The head may also include at least one roller located inside of the housing and configured to engage at least one of a ribbon and a sheet of reinforcement passing through the head. The head may further include a nozzle fluidly connected to the matrix reservoir, and a cure enhancer located outside of the housing and adjacent the nozzle.
US10850444B2	Method and apparatus for fabricating three-dimensional object A three-dimensional fabrication apparatus includes a fabrication chamber, a liquid discharge device, a vibration applicator, and a controller. In the fabrication chamber, powder is layered to form a powder layer, the powder of the powder layer is bonded together in a desired shape to form a layered fabrication object, and another layered fabrication object is laminated on the layered fabrication object. The liquid discharge device discharges a fabrication liquid onto the powder in the fabrication chamber. The vibration applicator applies vibration to the powder layer onto which the fabrication liquid is discharged from the liquid discharge device. The controller controls and drives the vibration applicator to apply vibration to the powder layer when the liquid discharge device discharges the fabrication liquid onto the powder layer to form the layered fabrication object.
US10850442B1	Medical devices and methods for producing the same The present disclosure relates generally to medical devices, including airway stents, and additive manufacturing (3D printing) processes for producing the same. Using certain materials and novel printing techniques, the present systems and methods can directly print nearly any size or shape medical device in a few hours. For example, in certain embodiments, the present systems and methods leverage fused deposition modeling (“FDM”) and polycarbonate urethane (“PCU”) to produce custom medical devices, including airway stents.
US10850439B2	Injection molding machine An injection molding machine is provided with a nozzle touch mechanism configured to press a nozzle attached to an injection device against a mold, a drive unit configured to move the injection device, a drive compression member connected to the drive unit, an injection compression member connected to the injection device, at least one resilient member interposed preloaded between the drive compression member and the injection compression member, and at least one strain sensor mounted on the drive compression member.
US10850435B2	Foam molded article mold and foam molded article A foam molded article mold includes a lower mold with a cavity space; an upper mold formed with an upper mold face portion facing a lower mold face portion of the cavity space when the upper mold has been brought together with the lower mold; a partitioning wall that projects out from the upper mold face portion, and that configures a first parting line between the partitioning wall and the lower mold face portion in a state in which the upper mold has been brought together with the lower mold; and a partition that projects out from the lower mold face portion, and that, in a state in which the upper mold has been brought together with the lower mold, partitions the cavity space together with the partitioning wall to form plural cavities, and that configures a second parting line between the partition and the partitioning wall.
US10850434B2	Single-phase solution molding Aspects hereof provide methods for molding a single-phase solution comprised of a polymer composition and a gas. The polymer composition and the gas are maintained under pressure during the molding operation to prevent a cellular structure from being formed by the dissolved gas in the polymer composition coming out of solution. The mold cavity in which the single-phase solution is introduced for molding purposes is pressurized to a mold pressure that is sufficient to maintain the single-phase solution as a single-phase solution as the mold cavity is filled. Subsequent to filling the mold cavity with the single-phase solution under pressure, the resulting article may solidify entrapping the compressed gas, or the article may be exposed to a reduction in pressure causing the entrapped gas to form a cellular structure.
US10850430B2	Process for producing tack-free hotmelt material and device for producing the same The present invention relates to a process for producing a hot melt adhesive (HMA) material, preferably hot melt pressure sensitive adhesive (HMPSA) material, having a substantially tack-free coating comprising a novel moulding and spraying step, wherein said HMA material, preferably HMPSA material, can be easily handled, packed and transported for further use. In addition, the present invention relates to a corresponding device for producing a hot melt adhesive (HMA) material, preferably hot melt pressure sensitive adhesive (HMPSA) material, having a substantially tack-free coating.
US10850425B2	Lightweight, reduced density fire rated gypsum panels A reduced weight, reduced density gypsum panel that includes high expansion vermiculite with fire resistance capabilities that are at least comparable to (if not better than) commercial fire rated gypsum panels with a much greater gypsum content, weight and density.
US10850418B2	Cutter calibration A cutter is positioned at a cutting position according to a virtual coordinate system. Media is cut at the cutting position using the cutter to create a cut. The actual location of the cut in the media is detected and the virtual coordinate system is calibrated based on an offset between the cutting position and the actual cut location.
US10850416B2	Apparatus and method for slicing food products The invention relates to an apparatus for slicing food products, in particular to high-performance slicers, having a cutting region at whose end a cutting blade moves, in particular in a rotating and/or revolving manner, in a cutting plane, and having a transport device which transports products to be sliced in a direction of transport over one track or multiple tracks to the cutting region, with the transport device comprising a plurality of positioners for the products in the or each transport track driven simultaneously in the direction of transport and arranged spaced apart from one another in the direction of transport.
US10850415B2	Pelletizing knife with removable blade A blade (6) for underwater granulation of an extruded polymer, this blade has a plate (60) bounded by a contour including a cutting edge contour (61) having a first end (62) and a second end (63), and an outer contour (64) linking the first end (62) and the second end (63) of the cutting edge contour (61). The outer contour (64) has at least a first bearing portion (65) and a second bearing portion (66), the first bearing portion (65) and the second bearing portion (66) diverging while extending away from the cutting edge contour (61) and configured to be received in a dovetail housing (13).
US10850413B2	Rotary cutter safety insert A rotary cutter insert can include a body configured to cover a first portion of a surface of a rotary blade. Further, the body of the rotary cutter insert can have an angled cutout configured to expose a second portion of the surface of the rotary blade so a rotary cutter can be used while the rotary cutter insert is in place. The rotary cutter insert reduces the area of exposed rotary blade that could potentially injure a user, thus making the rotary cutter significantly safer.
US10850410B2	Electrical appliance for performing a cutting action on hairs as present on an area of skin An electrical appliance for performing a cutting action on hairs present on an area of skin (7) comprises at least one assembly of a driven internal cutting member (5) for cutting off the hairs and an external cutting member (6) which serves for contacting the area of skin (7) and also for covering and contacting the internal cutting member (5). The cutting members (5, 6) are designed such that friction between them is related to their condition of wear in a predetermined way. Information relating to an actual condition of wear of the cutting members (5, 6) is determined by measuring a parameter related to the friction between the cutting members (5, 6) and processing the parameter, and such information is indicated to a user of the appliance.
US10850406B2	Non-planar shearing auxetic structures, devices, and methods Non-planar shearing auxetic structures, devices, and methods are provided herein. In some embodiments, a non-planar shearing auxetic structure can include a mathematically compact surface with an auxetic pattern of repeating unit cells. The shearing auxetic structure can have a contracted configuration and an expanded configuration, and, when in the compact configuration, can be configured to move to the expanded configuration while generating a net shear on the surface. Shearing auxetic structures can have handedness and, in some embodiments, multiple handed shearing auxetic structures can be joined to create rigid or semi-rigid composite structures, e.g., by arranging differently-handed structures concentrically wherein two or more structures lock against each other. Handed shearing auxetic structures can also provide actuators to convert rotation or other motion to translation, volume expansion, bending, twisting, etc. These structures have many applications, e.g., deployable structures such as pressure vessels, space habitats, fluid carrying vessels, soft robotics, toys, etc.
US10850402B2	Systems and methods for acquiring and moving objects An end effector system is disclosed for a robotic system that includes a primary acquisition system that includes a primary end effector, and a secondary retention system that substantially surrounds at least a portion of the primary acquisition system, wherein at least a portion of the primary acquisition system may be drawn up within at least a portion of the secondary retention system such that the primary end effector system may be used to select an object from a plurality of objects, and the secondary retention system may be used to secure the object for rapid transport to an output destination.
US10850401B2	Soft robotic actuators and methods of manufacturing the same Exemplary embodiments relate to various improvements in soft robotic actuators, and techniques for manufacturing the improvements. For example, techniques for manufacturing a rigidizing layer for reinforcing a soft robotic actuator is provided. In another embodiment, a soft robotic actuator having integrated sensors is described. A flexible electroadhesive pad for achieving a conformal grip is also described. Still further, exemplary embodiments provide hydraulically-actuated soft robotic grippers, which allows for a reduction in the size of the actuation system and improved underwater operation.
US10850394B2	Driving device A controller includes a first transmission unit that transmits identification information designating one servo-motor from among the servo-motors, an operation detection unit that detects an operation aspect of the driving device that is caused by a movement of the drive section driven by the servo-motor which is operated by the drive controller based on the identification information transmitted by the first transmission unit, and a correspondence information generation unit that creates correspondence information indicating which servo-motor among the servo-motors the identification information transmitted by the first transmission unit corresponds to, based on the detected operation aspect.
US10850393B2	Method for extending end user programming of an industrial robot with third party contributions There is provided a method for programming an industrial robot, where distributors and integrators can present accessories that run successfully at end users. Also the developer can define customized installation screens and program nodes for the end user. There is provided a software platform, where the developer can define customized installation screens and program nodes for the end user thereby extending an existing robot system with customized functionalities by still using the software platform available in the robot system. Hereby a robot developer can define customized installation screens and program nodes for the end user. These can, for example, encapsulate complex new robot programming concepts, or provide friendly hardware configuration interfaces.
US10850391B2	Pressurizing housing for a soft robotic actuator Exemplary embodiments relate to pressurizable housings for a soft robotic actuator. The pressurized housings may be divided into an upper chamber in fluid communication with an internal void of the actuator, and a lower chamber connected to an inlet and an outlet. The upper chamber and lower chamber may be separated by a piston. By supplying a fluid to the lower chamber via the inlet, the piston is moved into the space previously occupied by the upper chamber, which reduces the volume of the upper chamber and increases the pressure in the internal void. This action allows the actuator to be rapidly inflated, and further simplifies the pressurization system and reduces its weight.
US10850389B2	Systems and methods for a multi-axis robotic platform for studying neuromechanics of an ankle joint A multi-axis robotic platform for studying neuromechanics comprises a bottom plate, a middle plate, and a top plate is disclosed herein. The middle plate is movably coupled between the bottom plate and the top plate. The top plate comprises a support surface for receiving an ankle. A first actuator is disposed upon the bottom plate and is connected to the middle plate via a first coupling such that a shaft of the first actuator rotates the middle plate along a dorsiflexion-plantarflexion (DP) axis of the ankle. A second actuator is disposed upon the middle plate and is connected to the top plate via a second coupling such that a shaft of the second actuator rotates the top plate along an inversion-eversion (IE) axis of the ankle. The multi-axis robotic platform can analyze ankle impedance and reflex characteristics in two degrees-of-freedom (DP movement and IE movement) during postural and locomotion tasks.
US10850388B2	Exoskeleton sub-assembly and exoskeleton structure including such a sub-assembly The invention relates to an exoskeleton sub-assembly (30) comprising: —a leg part (32) to be attached to a leg of a user, and—a foot part (33) to be attached to a shoe of the user; the leg part (32) comprises a tibial segment (321) extending below the knee, along the tibia of the user, when the leg part (32) is attached to the leg, and the tibial segment (321) comprises a first component (325), a second component (326) connected to the foot part (33), and a first joint (327) connecting the second component (326) to the first component (325), the first joint (327) permitting a rotation of the second component (326) with respect to the first component (325) caused by an internal or external rotation of the user's foot with respect to the leg.
US10850384B1	Housing for utility tool accessory inserts and tool accessory inserts An insert for a utility tool includes a housing; a circular portion extending from a rear surface of the housing, the circular portion having a first diameter; a circular button extending from the circular portion, the button having a second diameter less than the first diameter; means for securing the housing on the utility tool; and a tool accessory secured within the housing. Tool accessories may include a laser, an LED light, and a bubble level, among others.
US10850382B1	Drive pliers A collapsible dual screwdriver assembly pliers or drive-pliers for short, comprises a pliers and two screwdriver assemblies, where the screwdriver assemblies are individually removably attachable in a stowed position and an extended position. In the stowed position each screwdriver assembly can provide compact storage of the tool as well as function as a portion of a handle for the other screwdriver assembly. In the extended position each screwdriver assembly can be used as an extended handle for the pliers, as well as, function as a multi-bit screwdriver individually.
US10850379B2	System and method for installing roof tiles A method for installing a roof tile covering on a roof structure comprising: providing a plurality of roof tiles comprising a porcelain body and an attachment hole above the roof structure; placing and fixing a part of the plurality of roof tiles onto the roof structure, forming a horizontal row; interrupting the horizontal row at a distance from a hip or valley of the roof structure; cutting a roof tile to provide a triangular or trapezoidal piece comprising one or more attachment holes; placing and fixing the triangular or trapezoidal piece onto the roof structure over the hip or valley, leaving a gap between the triangular or trapezoidal piece and the plurality of roof tiles in the horizontal row; and placing and fixing at least one roof tile on the roof structure over the gap, wherein the roof tile covering comprises a plurality of horizontal rows of roof tiles.
US10850378B2	Fuel cartridge for a gas-powered fixing tool and a gas-powered fixing tool having such a cartridge Various embodiments of the present disclosure provide a fuel cartridge for a gas-powered fastener-driving tool. In one embodiment, the fuel cartridge comprises a body that has a longitudinal axis and that defines an internal fuel storage cavity. The body is shaped and sized to be inserted at least partially into and removed from a housing defined by a case of the tool via translation along the longitudinal axis. The cartridge also includes a connection and fuel dispensing end fitting connected to the body and sized and shaped to engage an end fitting of the tool within the housing. The cartridge also includes a first cam surface extending at least partially around the longitudinal axis and configured to, during relative rotation of the first cam surface and a second cam surface, engage the second cam surface to facilitate removal of the fuel cartridge from the housing.
US10850377B2	Hand-held power tool, and method for operation A hand-held power tool, in particular a riveting machine, nailing machine, or drywall screwdriver, includes a device configured to detect a contact pressure of the hand-held power tool against a workpiece and an operating switch configured to manually activate the hand-held power tool. The hand-held power tool further includes a controller that monitors the contact pressure that is detected by the device starting from operation of the operating switch and activates the hand-held power tool when the detected contact pressure exceeds a prespecifiable limit value.
US10850376B2	Tensioning device A tensioning device is configured to apply upward tension to a bolt-nut fastener including a bolt fitted with a fastened member H, and a nut to be fastened to a shaft of the bolt, which protrudes from the fastened member. A first male thread portion is formed on an outer circumferential surface of the nut. The tensioning device includes a connection member having a first female thread portion to be engaged with the first male thread portion, a tensioning mechanism for tensioning the nut via the connection member in a state where the first male thread portion is engaged with the first female thread portion, and a tension bearer which is disposed around an outer circumference of the connection member, and bears a reaction force applied from the fastened member H in tensioning performed by the tensioning mechanism.
US10850374B2	System for controlling a portable tool with autonomous energy source, corresponding portable tool, module and control method A system for controlling a portable tool with autonomous energy source, implementing at least one geo-positioning beacon external to the tool and capable of communicating with the portable tool. The system includes the following elements carried by the portable tool: a receiver, in or on the portable tool, for receiving control information delivered by the at least one beacon; and a processing unit, which determines the presence of the portable tool within or outside at least one pre-determined space, from the control information, communicates with a controller capable of managing the behavior of the tool as a function of the presence of the portable tool within or outside the pre-determined space or spaces and at least one pre-determined production rule.
US10850373B2	Methods of using a fastener guide to install a fastener A fastener guide defines a downward opening funnel having an upper end that transitions to an elongated barrel in which a drive feature is movably disposed. The funnel can fit over an upright fastener so that a head is guided into and enters the barrel a distance so the drive feature can align and register with the head in the barrel before the drive feature advances the fastener through the funnel. The guide can include a guide sleeve and a biasing element interposed between the sleeve and the barrel to urge the barrel from a retracted mode to an extended mode. The barrel can telescope relative to the sleeve in transitioning from the extended mode to the retracted mode, for example, when the funnel engages a board and the drive feature advances the fastener. The biasing element can compress during this telescoping. Related methods of using the guide are provided.
US10850371B2	Anvil for an impact wrench An anvil for use with an impact wrench includes a first end, a second end opposite the first end, a shank adjacent the first end, and a head adjacent the second end. The shank includes a diameter and an outer cylindrical surface that defines a longitudinal axis that extends centrally through the anvil between the first end and the second end. The head includes a plurality of planar faces and an outer cylindrical surface. The outer cylindrical surface defines a diameter of the head. A ratio between the diameter of the shank and the diameter of the head is between approximately 1:1 and approximately 1.35:1.
US10850369B2	Grinder/polisher apparatus and a grinding element therefor A grinder/polisher apparatus is disclosed, the apparatus comprising first and second sets of grinding elements (2, 3) facing each other under an angle (α) thus forming between the sets of grinding elements a V-groove in which the cutting edge of a knife is insertable for movement upon grinding, wherein the grinding elements are supported in holders (5, 6). The grinding elements (2, 3) are pivotally arranged in the holders (5, 6) about axes (R, R′) the inclinations of which correspond with the opening angle (α) of the V-groove.
US10850363B2	Manufacturing method of semiconductor device and semiconductor manufacturing apparatus In accordance with an embodiment, a manufacturing method of a semiconductor device includes detecting elastic waves, and detecting or predicting an abnormality of the processing object occurring during polishing of the processing object. The elastic waves are generated from the processing object during the polishing. The abnormality is detected or predicted by analyzing the detected elastic waves.
US10850362B2	Method of manufacturing ophthalmic lenses and system for the manufacturing of such ophthalmic lenses The invention concerns a method of manufacturing an ophthalmic lens, comprising the steps of providing, mounting and blocking a substrate (10) on a machining support unit (65), surfacing an upper face (12) of said substrate, edging a peripheral edge (13) of said substrate, wherein said machining support unit comprises a surfacing member (40) and an edging member (30) which are separable, said surfacing member having a cavity (51) in which said edging member is located during said step of surfacing, said surfacing and edging members being configured so that said substrate is mounted and blocked on said machining support unit in a first predetermined position for the surfacing and the edging and, between said steps of surfacing and edging, the method comprises the step of withdrawing said surfacing member from said machining support unit by retaining said substrate on said edging member.
US10850361B1	Powered sharpener with manual hone stage Apparatus and method for sharpening a cutting tool, such as a kitchen knife. A sharpener has a base unit and one or manual sharpening modules. The base unit has a housing which encloses at least one flexible abrasive disc rotated by an electric motor. Each flexible abrasive disc is adjacent a powered sharpening stage to perform a primary sharpening operation upon the tool. Each manual sharpening module may be removably attachable to the base unit and has a manual sharpening stage that incorporates at least one sharpening element to perform a secondary sharpening operation upon the tool. Each manual sharpening module further has a powered stage guide surface to form a portion of a corresponding powered sharpening stage. When two powered sharpening stages are used, the manual sharpening module(s) can be individually placed between the powered sharpening stages to provide opposing powered stage guide surfaces for each.
US10850359B2	Indexing tool An indexing tool for positioning a workpiece, the tool comprising a block having sides, the sides defining a regular polygon. The block has a central opening, and a threaded hole extending at a right angle to the central opening and into and through one of the sides. The block also has a V notch in the block wall opposite the threaded hole, the threaded hole being adapted to have received therein a like threaded set screw.
US10850357B2	Machine tool Machine tool including a workpiece carrier assembly including a workpiece carrier for supporting a plurality of workpieces, the workpiece carrier assembly being supported on a workpiece carrier support for horizontal movement in a first direction parallel with a horizontal Z axis, a tool carrier configured for carrying a plurality of tools corresponding to the plurality of workpieces and for machining the workpieces, the tool carrier being supported on a tool carrier support for horizontal movement in a second direction parallel to a horizontal X axis, the X axis being perpendicular to the horizontal Z axis, where the tool carrier is displaceable on the tool carrier support in the second direction between an operative position in which the tools are arranged for the contacting the workpieces and an inoperative position in which the workpieces are not contactable by the tools, where the workpiece carrier is arranged to be rotatable around an axis parallel with the X axis, and where the workpiece carrier includes a workpiece support area for supporting the workpieces and arranged substantially in parallel with the X axis.
US10850356B2	Aluminum metal-cored welding wire The present disclosure relates to a metal-cored welding wire, and, more specifically, to a metal-cored aluminum welding wire for arc welding, such as Gas Metal Arc Welding (GMAW) and Gas Tungsten Arc Welding (GTAW). A disclosed metal-cored aluminum welding wire includes a metallic sheath and a granular core disposed within the metallic sheath. The granular core includes a first alloy having a plurality of elements, wherein the first alloy has a solidus that is lower than each of the respective melting points of the plurality of elements of the first alloy.
US10850353B2	Method and system for enabling synchronous sheet transfer to follow laser cutting dynamically The present invention provides a system for enabling synchronous sheet transfer to follow laser cutting dynamically. A laser-cutting method for the system for enabling synchronous sheet transfer to follow laser cutting dynamically is also provided. With the system and method of the present invention, dynamic following of sets of magnetic belts during the cutting procedure is implemented, thereby accelerating the processing pace, and further improving the throughput.
US10850352B2	Method of laser cutting grooves in a friction clutch plate A friction clutch assembly for an automatic transmission, a friction clutch plate, and a method of forming a friction clutch plate are provided. The method includes providing a friction material layer for a face of the friction clutch plate and cutting the friction material layer with a laser beam to form a plurality of grooves within the friction material layer. In one version, a friction plate for the friction clutch assembly includes an annular core plate having first and second opposed faces and defining an outer edge and an inner edge. Friction material is affixed to at least one of the first and second opposed faces. The friction material defines a plurality of grooves within the friction material, each groove being bordered by friction material having a ridge. The cross-section of the ridge has a corner having a radius of curvature that is less than 300 microns.
US10850348B2	Device and method for alignment of parts for laser welding A device and method for alignment of parts for welding, having a bottom welding fixture and a top welding fixture. The bottom welding fixture has a plurality of fixed locating pins for positioning of parts to be welded and limiting movement of the parts in a first axis and a perpendicular second axis. At least pair of alignment block assemblies to actuate movement of the parts to be welded in the first and second axes. The alignment block assembly having an alignment block moveable from a first position to a second position for contacting and aligning the parts. An actuator coupled to the top welding or bottom welding fixture to actuate movement of the alignment block from the first position to the second position upon engagement of the top welding fixture to the bottom welding fixture.
US10850345B2	Shaping device for roller electrode for seam welding Provided is a shaping device for a roller electrode for seam welding that prepares shapes for a first roller electrode and a second roller electrode attached to an arm of a robot. This shaping device is provided independently from the robot and disposed within rotational range of the arm, and is provided with a first roller and a second roller that are disposed on a line orthogonal to a line joining the rotational centers of the first and second roller electrodes and are in contact with the outer circumferences of the first and second roller electrodes.
US10850343B2	Spatter analysis method and device A spatter production information storage unit stores spots where spatter has been produced. For the spots where spatter has been produced, a comparison information generation unit acquires weld design information stored in a design information storage unit and weld instruction information stored in an instruction information storage unit, compares both pieces of information, and generates comparison information. An image information output unit outputs the generated comparison information to a display device. The display device displays the comparison information on a screen so as to allow checking by an operator. Hence, it is possible to check, on the screen, comparison information for weld instruction information and weld design information highly likely as a cause for spatter being produced, and to efficiently perform the task of analyzing the causes for spatter being produced.
US10850339B2	Geometric control and best fitting of electric discharge machining tools A method for checking a geometry of an electric discharge machining electrode is described. The method comprises the following steps: providing a file containing a native 3D-model of the electric discharge machining electrode; providing a manufactured electric discharge machining electrode based on the native 3D-model; light scanning a set of images of the manufactured electric discharge machining electrode in different positions and generating therewith a scanned 3D-model of the manufactured electric discharge machining electrode; comparing the native 3D-model and the scanned 3D-model and generating electrode compensation coordinates for an electric discharge machining apparatus, to correct an electrode path during electric discharge machining.
US10850338B2	Electric power tool An electric power tool includes a drive device for providing a driving force, a rotation wheel that has a central axis and is driven by the drive device to rotate around the central axis, a spindle that supports a tool holder configured to hold a tool of the electric power tool, a first intermediate member, a second intermediate member, and a counterweight device. The first intermediate member is offset from the central axis of the rotation wheel, and revolves around the central axis when driven by the rotating rotation wheel, while driving the spindle to reciprocate in a first direction. The second intermediate member is driven by the first intermediate member to rotate around the central axis and is disposed to be offset from the central axis of the rotation wheel on the side opposite the first intermediate member. The counterweight device is driven by the second intermediate member.
US10850336B2	Coolant bonnet for a cutting tool A coolant bonnet for a cutting tool includes a head portion, a shank portion, an internal coolant passage extending through the shank portion and into a coolant manifold disposed within the head portion, and one or more coolant ducts extending radially outward from the manifold to an outlet port. Each coolant duct is aligned with the chip flutes of the cutting tool and directs coolant at a predetermined exit angle in an axially rearward direction toward the cutting edges of a cutting insert mounted on the cutting tool. A method of providing coolant to a cutting edge of a cutting insert mounted on the cutting tool is also disclosed.
US10850334B2	Mold for resin sealing a semiconductor chip, and semiconductor device having resin-sealed semiconductor chip A mold is configured to resin-seal a semiconductor chip to form a semiconductor package. The mold has a first mold cavity and a second mold cavity formed in the bottom of the first mold cavity with a stepped portion between the two mold cavities. The two mold cavities are formed in succession by a high-speed rotary cutter having a downwardly tapered round cutting surface that imparts a corresponding taper to walls of the two mold cavities.
US10850330B2	Process for producing nickel powder A process for producing nickel powder capable of obtaining inexpensive, and also, high-performance nickel powder, even when using wet process. A process for producing nickel powder, including a crystallization step for obtaining nickel crystal powder by reductive reaction in reaction solution in which at least water-soluble nickel salt, metal salt of metal more noble than nickel, reducing agent, alkali hydroxide, amine compound, and water are mixed, wherein the reducing agent to be mixed in the crystallization step is hydrazine, the amine compound is autolysis inhibitor of hydrazine, and contains two or more primary amino groups in molecule, or contains one primary amino group and one or more secondary amino groups in molecule, and ratio of molar number of the amine compound with respect to molar number of nickel in the reaction solution is in a range of 0.01 mol % to 5 mol %.
US10850328B1	Method of making iron matrix composite The disclosure provides a method of making an iron matrix composite. A Fe—Ni—P composite powder having a particle size of one to two micrometers and a Fe—N powder having a particle size of 100 to 250 nanometers are used as the raw material. The size and axial displacement of pressing heads of a graphite mold are controlled to realize the control of the porosity of porous iron. The composite produced comprises two surface layers of a Fe—Ni—P alloy and an intermediate layer of porous iron having a porosity of 14 to 39%. The method enables a reduced weight of the Fe—Ni—P alloy and enables shock absorption and damping properties to be imparted to the composite. In addition, an optional subsequent deep cryogenic treatment allows the Fe—Ni—P alloy to be subjected to phase transition from a metastable gamma-phase to an alpha-phase, thereby substantially improving the hardness and strength thereof.
US10850324B1	Titanium-group nano-whiskers and method of production Disclosed herein are structures comprising a titanium, zirconium, or hafnium powder particle with titanium carbide, zirconium carbide, or hafnium carbide (respectively) nano-whiskers grown directly from and anchored to the powder particle. Also disclosed are methods for fabrication of such structures, involving heating the powder particles and exposing the particles to an organic gas.
US10850320B2	Apparatus for low-pressure casting An apparatus for low-pressure casting includes a furnace wall bounding a furnace chamber, a melting crucible unit located in the furnace chamber, a heating device for heating the melting crucible unit, and at least one pressurizing unit for applying overpressure to the melting crucible unit. The furnace chamber in a top view has a length which is greater than its width, so that the furnace chamber has an elongated shape in a longitudinal direction, wherein preferably several riser pipes extending vertically are distributed roughly evenly over around 60% to 95% of the length in the longitudinal direction of the melting crucible or crucibles.
US10850315B2	High-toughness and plasticity hypereutectoid rail and manufacturing method thereof Provided is a manufacturing method for high-toughness and plasticity hypereutectoid rail, including: a. hot rolling the steel billet into rail; b. blowing a cooling medium to the top surface of railhead, wherein, the two sides of railhead and the lower jaws on the two sides of railhead after the center of top surface of rail is air-cooled to 800-850° C., and cooling the rail until the center temperature of the top surface is 520-550° C.; c. stop blowing the cooling medium to the lower jaws on the two sides of railhead, continue blowing the cooling medium to the top surface of railhead and the two sides of railhead, and air cool the rail to room temperature after the surface temperature of railhead is cooled to 430-480° C. The resulting hypereutectoid rail has higher toughness and plasticity than existing products, which is suitable for heavy-haul railway, especially for small radius curve sections.
US10850309B2	Sonotrode apparatus and device for acoustic levitation, and control device and method Sonotrodes are used when examining substances on the basis of acoustic levitation. In order to obtain a reproducible measurement result or to extend the possible uses of devices of this kind, the respective sonotrode has to meet a whole range of requirements. Exact tuning of the frequency and clean interaction between the sonotrode and a frequency generator are particularly important. The present invention proposes that a sonic horn and a main body of the sonotrode are provided as different parts and, in this case, the sonic horn can be mounted on or in the main body in a specific manner, in particular for operation at low voltage in such a way that the amplitude or operating voltage remains below a comparatively low maximum low-voltage value, in particular 50 Vpp. The formation of heat can be prevented in this way. The present invention further relates to a control or production method for a sonotrode apparatus of this kind. In this case, it is respectively possible to extend the range of use and to improve the reproducibility or quality of the measurement results.
US10850307B2	Ultrasonic device An ultrasonic device includes a substrate having an opening portion penetrating through the substrate in a thickness direction; a membrane formed on the substrate and having a movable film defining a top surface portion of the opening portion; a lower electrode formed on a front surface of the membrane at a side opposite the opening portion; a piezoelectric film formed on a front surface of the lower electrode at a side opposite the membrane; and an upper electrode formed on a front surface of the piezoelectric film at a side opposite the lower electrode, wherein the movable film of the membrane has a shape that is deflected so as to be convex toward the lower electrode, and wherein the lower electrode is an IrOx/Ir/Ti/Pt laminated film with which an IrOx film, an Ir film, a Ti film, and a Pt film are laminated in that order from the membrane.
US10850300B2	Holding device for the surface treatment of bar cutters A holding device for fastening bar cutters in order for the cutting edges thereof to be coated, wherein the fastening is configured in such a way that a plurality of bar cutters can be arranged in a row such that the cutting faces and tips thereof have the same orientation, and the holding device includes a screen which at least partially protects the cutting faces from the coating, wherein, with bar cutters arranged in a row in the manner described, the top edge of the screen projects beyond the knife tips in such a way that no knife tips protrude.
US10850298B1	System for non-contact coating of moving component through a falling flow of coating material An apparatus for coating an object or component includes at least one dispenser for dispensing a falling flow of material and an actuator for projecting the component through the falling flow of material. A landing may also be provided for receiving the coated projectile, the landing adapted for providing a second coating to the coated projectile. Related methods are also disclosed.
US10850290B2	Spraygun with built-in quick-fit connector A spray gun and a detachable liquid reservoir releasably attached to the spray gun by engagement of mateable, non-threaded formations provided on the spray gun and the reservoir. The spray gun has an integral connector boss with a socket for reception of a connector tube of the reservoir. The boss has an external flange at the distal end and the reservoir has hook members separate from the connector tube. The hook members are co-operable with the flange when the connector tube is received in the socket to secure releasably the reservoir to the spray gun. In another arrangement, the connector tube is an interference friction-fit in the socket to secure releasably the reservoir to the spray gun. In yet another arrangement, the connector tube has bayonet lugs co-operable with bayonet grooves in the wall of the socket when the connector tube is received in the socket to secure releasably the reservoir to the spray gun. In a still further arrangement, the reservoir has an integral spout received in the socket integral with the spray gun and provided with a helical projection co-operable with the underside of a radial lug externally of the socket to secure the reservoir.
US10850288B2	Centrifugal separator with feed pipe having spiral grooves A centrifugal separator, especially disc stack separator for separation of a suspension or mixture, has a feeding unit with an inlet and a stationary pipe. The pipe extends longitudinally from the top of the centrifugal separator through a stack of filter discs and has an opening directed to the accelerator disc a separator bowl of the centrifugal separator. The feed pipe is corrugated with spiral grooves running in the longitudinal direction of the pipe. The suspension flow is directed in the direction of rotation of the separator bowl and a soft infeed of the suspension to the accelerator disc and bowl without mechanically destroying particles or molecules of the suspension or mixture is achieved.
US10850282B2	Multiplex PCR chip and multiplex PCR device comprising same According to one embodiment of the present invention, a multiplex PCR device is disclosed. The multiplex PCR device comprises a multiplex PCR chip simultaneously carrying a plurality of mutually different nucleic acid molecules, and the invention may be characterised in that, attached spaced apart from each other on the multiplex PCR chip, there are a plurality of probes used for hybridization reactions whereby hybridization takes place specifically with mutually different amplified sequences of the nucleic acid molecules.
US10850280B2	Method for internally coating a liquid test sample collection device with at least one anticoagulant compound, and devices and kits related thereto Methods, devices, and kits, related to embodiments for uniformly coating at least one inner surface of a capillary with at least one anticoagulant compound.
US10850276B2	Systems and methods for capture and detection of low copy targets from large sample volumes Systems and methods that enable the rapid identification of target molecules present in a sample at low concentrations is provided. The system includes a sample volume, and a detection structure that is connected to the sample volume by a conduit. The detection structure includes a microfluidic chip that defines a plurality of fluid channels. The walls of the fluid channels are formed from or covered with a metal oxide to which target molecules attach. After the sample volume has been passed through the detection structure, and in particular through the channels, visible microparticles are passed through the detection structure. The visible microparticles are configured to have an affinity for the target molecules. The microfluidic chip is then imaged to detect visible microparticles, and to thereby obtain information regarding the presence of the target molecules.
US10850270B2	Preparation method of carbon-supported metal oxide and/or alloy nanoparticles catalyst using physical vapour deposition Disclosed is a method for preparing a carbon-supported metal oxide and/or alloy nanoparticle catalyst. According to the method, a carbon-supported metal oxide and/or alloy nanoparticle catalyst is prepared by depositing metal oxide and/or alloy nanoparticles on a water-soluble support and dissolving the metal oxide and/or alloy nanoparticles deposited on the water-soluble support in an anhydrous polar solvent containing carbon dispersed therein to support the metal oxide and/or alloy nanoparticles on the carbon. The anhydrous polar solvent has much lower solubility for the water-soluble support than water and is used to dissolve the water-soluble support. The use of the anhydrous polar solvent instead of water can prevent the water-soluble support present at a low concentration in the solution from impeding the support of the nanoparticles on the carbon, thus providing a solution to the problems of environmental pollution, high cost, and complexity encountered in conventional chemical and physical synthetic methods.
US10850265B2	Molecular sieve catalyst compositions, catalytic composites, systems, and methods Described is a selective catalytic reduction catalyst comprising a zeolitic framework material of silicon and aluminum atoms, wherein a fraction of the silicon atoms are isomorphously substituted with a tetravalent metal. The catalyst can include a promoter metal such that the catalyst effectively promotes the reaction of ammonia with nitrogen oxides to form nitrogen and H2O selectively over a temperature range of 150 to 650° C. In another aspect, described is a selective catalytic reduction composite comprising an SCR catalyst material and an ammonia storage material comprising a transition metal having an oxidation state of IV. The SCR catalyst material promotes the reaction of ammonia with nitrogen oxides to form nitrogen and H2O selectively over a temperature range of 150° C. to 600° C., and the SCR catalyst material is effective to store ammonia at temperatures of 400° C. and above. A method for selectively reducing nitrogen oxides, and a method for simultaneously selectively reducing nitrogen oxide and storing ammonia are also described. Additionally, an exhaust gas treatment system is also described.
US10850264B2	Hydrocarbon trap catalyst The present invention relates to a catalyst comprising a carrier substrate of the length L extending between substrate ends a and b and a first washcoat zone, which comprises a) a zeolite, b) a redox active base metal compound and c) palladium in oxidic or metallic state which is fixed to the surface of a support oxide.
US10850261B2	Oligomerization catalyst and process for the production thereof The invention relates to an oligomerization catalyst comprising nickel oxide and silica-alumina support material and to a process for oligomerization of C3- to C6-olefins using the oligomerization catalyst.
US10850260B2	Super absorbent polymer and method for producing same A super absorbent polymer and a method for producing the same are disclosed herein. In some embodiments, the super absorbent polymer includes a base polymer powder including a cross-linked polymer, and first and second surface cross-linked layers formed on the base polymer powder. The first and second surface cross-linked layers are formed by further cross-linking the cross-linked polymer in the presence of a surface crosslinking agent, wherein the first and second surface cross-linked layers each include a cross-linked structure derived from epoxy-based and non-epoxy-based surface crosslinking agents. The super absorbent polymer can exhibit excellent absorbent properties even in a swollen state and thus exhibit excellent anti-rewetting effects. Accordingly, when the super absorbent polymer is used, it is possible to provide a sanitary material such as a diaper or a sanitary napkin which can give a smooth touch feeling even after the body fluid is discharged.
US10850255B2	Synthesizing highly porous nanoparticles A system and method for synthesizing a nanoparticle material includes dissolving a metal nitrate in deionized water, adding a hydrogel precursor in the deionized water containing the dissolved metal nitrate to create an aqueous solution, heating the aqueous solution, cooling the aqueous solution to create a solid gel, and calcinating the solid gel to create a metal oxide nanoparticle material. The metal oxide nanoparticle material may include a zinc oxide-based nanoparticle material. The hydrogel precursor may include an agarose gel. The solid gel may be calcinated at approximately 600° C. The solid gel may be calcinated for approximately five hours in the presence of air. The aqueous solution may be heated to a boil. The aqueous solution may be heated at a temperature of ≤100° C.
US10850251B2	Radioactive cesium adsorbent and method of removing radioactive cesium using the same A radioactive cesium adsorbent includes photocatalyst particles and Prussian blue. The ferric ions of the Prussian blue are reduced to ferrous ions by activation of the photocatalyst particles. A method of removing radioactive cesium using the radioactive cesium adsorbent includes preparing a composition comprising photocatalyst particles and Prussian blue; preparing a precursor solution by mixing radioactive cesium and the composition prepared in the preparing of a composition; and reducing ferric ions of the Prussian blue to ferrous ions by activating the photocatalyst particles in the precursor solution prepared in the preparing of a precursor solution.
US10850250B2	Device and method for producing high-concentration, low-temperature nitric oxide A device and method for forming NO-containing gas flow to treat a biological object is disclosed. The device may include an anode, a cathode, an interelectrode area between the cathode and the anode, an NO-containing gas flow outlet channel leading from the interelectrode area to a nozzle for directing and releasing the NO-containing gas flow from the device and a mechanism to adjust a relative position between the anode and the cathode to produce varying concentrations of NO. In addition, the device may include one or more features for interconnecting the various components to ensure proper and consistent assembly of the device.
US10850247B2	Process with photopolymerization for preparing microcapsules of controlled size Solid microcapsules are prepared by adding, with stirring, a composition having at least one active ingredient to a photocrosslinkable polymeric composition to obtain an emulsion, and adding the emulsion, with stirring, to a viscous composition. The viscosity of the viscous composition is greater than 2000 mPa·s at 25° C. A double emulsion is obtained, to which shear is applied at a rate less than 1000 s−1, to obtain a sheared emulsion. Polymerization of the sheared emulsion is accomplished by photopolymerization.
US10850240B2	Fluid injection system A fluid injection system includes a container and fluid injection device. The fluid injection device includes a housing having a flow tube having an inlet end and an outlet end. A shroud is positioned between the inlet end and the outlet end and has a first end and a second end defining a ramped surface therebetween. The shroud redefines at least a portion of the fluid pathway as a constricted fluid pathway. A diverter port is between the inlet end and the shroud and diverts a portion of the inlet fluid into the container. An injection port is between the shroud and the outlet end and receives product from the container. The first end of the shroud includes a step defining a notch in fluid communication with the diverter port. The second end defines a recess in fluid communication with the injection port.
US10850238B2	Processes for reducing the fouling of surfaces Process for reducing the fouling of a surface O, wherein an aqueous solution S of at least one polymer P comprising styrene and at least one ester E of (meth)acrylic acid and polyethylene oxide in a molar ratio of 0.05:1 to 50:1 is applied to said surface O.
US10850236B2	Low dispersion, fast response mixing device A mixing system has a parallel droplet dispenser capable of making droplets of a first working material in the range of 10 nanometers to 10 micrometers, a pump to deliver fluid for the droplets of the first working material and to produce a first emulsion, a compact mixer having low inter-voxel mixing to receive the emulsion and produce a homogenous material, and a dispensing system. A method of dispensing a graded material includes generating droplets of a first working material, the droplets having a size in the range of 10 nanometers to 10 micrometers, adding the droplets of the first working material into a fluid to create a first emulsion, wherein addition of the droplets of the first working material is controlled to create gradient in the emulsion, mixing the first emulsion to create a homogenous, graded mixture, and dispensing the homogenous, graded mixture onto a surface.
US10850233B2	Fluid for purifying heat engines using stable suspensions of metal colloidal particles, and methods for preparing said fluid The present invention describes a fluid which is suitable for the decontamination of heat engines which can carry out both the catalytic reduction of oxides of nitrogen (NOx) contained in exhaust gases and assist in the regeneration of the particulate filter (PF), said fluid being in the form of a stable suspension of colloidal particles, these colloidal particles being dispersed in an aqueous solution containing at least one reducing agent or at least one precursor of a reducing agent for NOx. The invention also describes several embodiments for the preparation of said fluid.
US10850230B2	Process and system for removing sulfur dioxide from flue gas Processes and systems for producing potassium sulfate as a byproduct of a desulfurization process. Sulfur dioxide is absorbed from a flue gas using an ammonia-containing solution to produce an ammonium sulfate solution that contains dissolved ammonium sulfate. At least a first portion of the ammonium sulfate solution is heated before dissolving potassium chloride therein to form a slurry that contains potassium sulfate crystals and an ammonium chloride solution. The slurry is then cooled to precipitate additional potassium sulfate crystals, after which the potassium sulfate crystals are removed to yield a residual ammonium chloride solution that contains dissolved ammonium chloride and residual dissolved potassium sulfate. Ammonia is then absorbed into the residual ammonium chloride solution to further precipitate potassium sulfate crystals, which are removed to yield a residual ammonium chloride solution that is substantially free of dissolved potassium sulfate.
US10850228B2	Flow-optimized desiccant cartridge Disclosed is a desiccant cartridge (10) for drying and de-oiling a gaseous fluid, and a method for flow guidance within the desiccant cartridge. The desiccant cartridge and a housing (12) having positioned therein an inner pot (28) in which an oil separating medium (50) for oil particles contained in the fluid and a desiccant (52) for drying the gaseous fluid are arranged one after the other in the direction of the housing longitudinal axis (14). The housing (12) has a housing base (18) having a centrally arranged inlet (20) for the fluid to be dried and de-oiled and having eccentrically arranged outlet openings (24) for the dried and de-oiled fluid. During normal operation of the desiccant cartridge (10), the gaseous fluid guided into the desiccant cartridge (10) via the central inlet (20) is first guided in a flow through the oil separating medium (50) and then through the desiccant (52).
US10850221B2	Fine particle detector and exhaust gas purification apparatus A fine particle detector includes: a casing part configured to accommodate an object to be heated; an electromagnetic wave generating part configured to generate electromagnetic waves of different frequencies; at least one power sensor configured to measure powers, from the casing part, of the electromagnetic waves that have entered into the casing part; and a fine particle detection controlling part configured to determine, based on the powers of the electromagnetic waves of the different frequencies measured by the at least one power sensor, whether an accumulated amount of fine particles accumulated in the object to be heated is greater than or equal to a predetermined accumulated amount.
US10850218B2	Filtration method and production process of cellulose nanofiber dispersion A cellulose nanofiber with little contaminants and a high transparency is provided. A filtration method of a cellulose nanofiber dispersion including a step of filtering a cellulose nanofiber dispersion under elevated or reduced pressure by at least one of the filtration processes: (A) a filtration process using a filter aid; (B) a filtration process using a filter media selected from the group consisting of a metal porous filter media, an inorganic material porous filter media, and a polymer porous filter media; and (C) a filtration process using both the filter aid and the filter media.
US10850203B2	Virtual league platform of a sport activity The present disclosure describes a platform that allows individual users to compete against other users in a virtual league. The platform allows individual users to maintain personal performance statistics, which, collectively, are used to determine a projection result of the user's performance in a competition within the league. The platform employs projection result, in combination with, or as a substitute for, results associated with a real race completed by the user, in the scoring of the user against other competitors in the league.
US10850202B1	Systems and methods for distributions by an automated electronic networked central clearinghouse Systems and methods for controlling distributions by an automated electronic networked central clearinghouse are disclosed. Exemplary implementations may: receive an exchange request that indicates a first user offers a first digital asset for a reversible exchange on a fiat-currency-based online exchange platform; obtain asset-specific distribution rights for the first digital asset; receive exchange information regarding the reversible exchange with an exchanging user; monitor, during a waiting period, whether any actions taken by the exchanging user determine reversibility of the reversible exchange, or whether the waiting period for reversibility times out; based on a time-out or a determination regarding reversibility, either (i) transfer the ownership of the first digital asset to the first user, or (ii) clear the reversible exchange by non-temporarily transferring the ownership to the exchanging user, and by distributing benefits in accordance with the asset-specific distribution rights.
US10850197B1	Guided interactions with books A system for providing guided interactions with books includes a content delivery terminal communicatively coupled to a computing platform including a hardware processor and a memory storing a content delivery software code, a content registry, and a library of entries corresponding respectively to multiple interaction plans for guiding an interaction with a book. The hardware processor executes the content delivery software code to detect, via the content delivery terminal, a book corresponding to content included in the content registry, and to identify an interaction plan for the guided interaction based on one or more of the content and a user input received by the content delivery terminal. The content delivery software code further identifies a first portion of the content for use in initiating the interaction plan, and outputs the first portion of the content to the content delivery terminal for printing by the content delivery terminal in the book.
US10850196B2	Terminal device A terminal device controls a scroll display process for scrolling and moving a display region part of content displayed on a touch panel based on a slide operation input, and detects, during the slide operation input, any one input state of the number of slide operation inputs being simultaneously executed and the touch area involved in the touching on the touch panel for execution of the slide operation input, and controls a scrolling speed, which represents a moving speed exhibited when the display region part of the content is scrolled in the scroll display process, or a scroll movement amount, which represents a movement amount by which the content is scrolled, during the slide operation input based on the detected input state.
US10850194B2	Terminal display control method, terminal display system and server apparatus According to one embodiment, a terminal display control method for using as a controller of a game a terminal device including a touch panel, which is configured to be integral with a display, includes selecting a controller image which is used in the game; setting at least one of a presence/absence of a function, a number, a size, a shape and a position of disposition, with respect to an operation element in the controller image; and making variable, in accordance with a content of the setting, a state of the controller image displayed on the display, and an operation standard of the operation element corresponding to an input on the touch panel.
US10850191B2	Game system, non-transitory storage medium having stored therein game program, game apparatus, and game method A game system includes operation units, a game processing unit that performs game processing on the basis of operation onto the operation units, a waveform information generator that generates vibration waveform information representing a vibration waveform corresponding to a first event that occurs in the game processing, and vibration units that vibrate on the basis of the vibration waveform information. In a case where the first event continues, the waveform information generator generates the vibration waveform information such that the amplitude of the vibration waveform decreases in accordance with the lapse of time.
US10850190B2	Input device with clutched force-feedback trigger A user-input device includes a user-actuatable trigger configured to pivot about a trigger axis, a posture sensor configured to determine a posture of the user-actuatable trigger about the trigger axis, a force-feedback motor configured to activate based on a force-feedback signal, and a clutch operatively intermediate the user-actuatable trigger and the force-feedback motor and configured to mechanically change engagement between the user-actuatable trigger and the force-feedback motor.
US10850189B2	Method and apparatus for adapting to gaming venue states A system that incorporates teachings of the present disclosure may include, for example, a method for detecting that a gaming system has presented a first of a plurality of gaming venue states of a game, presenting a first of a plurality of screen shots at a display responsive to detecting the first gaming venue state, detecting that the gaming system has transitioned to a presentation of a second of the plurality of venue states, and presenting a second of the plurality of screen shots at the display responsive to detecting the second gaming venue state. Additional embodiments are disclosed.
US10850188B2	Wisdom ring puzzle A wisdom ring puzzle includes a base, a three-dimensional structure including a columnar structure and a first structure having an arched structure or an annular structure, and a member having an annular structure. The columnar structure has a first connection member and a first annular member. The columnar structure and the first structure are provided to face each other in a side view. The first connection member passes through the first structure and has one end connected to the columnar structure and another end to the first annular member. The columnar structure and the first structure is included inside a ring of the first annular member.
US10850185B2	Word-forming and word-guessing game A method for playing a word-forming and word-guessing board game (10) between at least a first player and a second player includes (i) each of the players selecting a letter tile set (20), a card deck (22) and a dice set (26); (ii) each of the players utilizing a predetermined number of letter tiles (20) from their letter tile set (20) to form a word that is hidden from each of the other players; (iii) the first player utilizing their card deck (22) and their dice set (26) to win an opportunity to guess the word of any of the other players; and (iv) the first player making a guess of the word of any of the other players.
US10850176B2	Sensor device To detect a motion of a hitting tool more precisely by a sensor, provided is a sensor device including: a base member configured to be mounted on a hitting tool via a fitting structure; a substrate joined to the base member; a sensor disposed on the substrate and configured to detect a motion of the hitting tool delivered via the base member and the substrate; a communication unit configured to transmit a detection result of the motion of the hitting tool to an external device; and an exterior member configured to cover the sensor and the communication unit.
US10850174B2	Golf club head with polymeric insert A golf club head includes a first portion joined to a second portion to at least partially define an interior club head volume. The first portion includes a wall defining an outer boundary of the club head volume, and a support rib extending from the wall to operatively stiffen the first portion. The second portion of the golf club head can engage the support rib, and the support rib can be adhered to the second portion to join the first portion and the second portion.
US10850165B2	Non-inflatable sports balls The present invention relates to sports balls. A sports ball comprises a surface layer comprising a plurality of panels. The sports ball further comprises a lattice structure extending below the surface layer, wherein the lattice structure comprises a plurality of lattice cells comprising radially extending elements. The lattice cells which are adjacent to the surface layer have at least one dimension which is smaller than an average diameter of the panels.
US10850161B2	Method and apparatus for electronically controlled resistance in exercise equipment A system and method for controlling a tension in an exercise apparatus are provided. The system includes an input/output (I/O) subsystem for permitting a user to enter at least one resistance value and for displaying a resistance exerted by the exercise apparatus; a controller configured to control the tension of the exercise apparatus based on the at least one resistance value entered by the user adjusting a position of a holder and moving a plurality of guides for selective attachment of tension members to catches on the exercise apparatus; and a power source connected to the controller and the I/O subsystem and configured to power the controller and the I/O subsystem.
US10850158B2	Multi-axis adjustable exercise machine A multi-axis adjustable exercise machine which is pivotable about both a pitch axis and a roll axis with respect to a base for allowing an exerciser to perform a wide range of exercises on a pitched or rolled exercise machine. The multi-axis adjustable exercise machine generally includes an exercise machine which is adjustable with respect to a base. The exercise machine may be pivoted about a roll axis to adjust the roll angle of the exercise machine or may be pivoted about a pitch axis to adjust the pitch angle of the exercise machine. One or more actuators may be connected between the base and the exercise machine to effectuate the pivoting of the exercise machine about either or both axes with respect to the base.
US10850154B2	Storable exercise bench A storable exercise bench is provided. The exercise bench may include a frame including at least one beam operatively coupled to first and second floor supports and a member operatively coupled with the at least one beam. The exercise bench may be positioned into an operating position in which the first and second floor supports support the at least one beam and the member, and the at least one beam runs generally horizontally in reference to a support surface. The exercise bench may be positioned into a storage position in which the second floor support and the member support the at least one beam and the first floor support, and the at least one beam runs generally vertically in reference to the support surface.
US10850139B2	Cowl neck barrier gown with attachments This invention offers a fully protective cowl neck garment with various fasteners designed to attach additional protective gear, such as gloves and shoe coverings. Additionally, a temperature sensor shield is located on the hat and protective mask. This allows the clients or patients the ability to see and to monitor the temperature of their caregivers. The caregiver's temperature is visible on the hat, as well as the face mask. This makes the caregivers accountable to their clients or patients, as well as their colleagues and coworkers. This invention eliminates the worry of contact with infectious diseases or dangerous liquids, by utilizing elastic manual ties and hook-and-loop fasteners to ensure the garment is secured fully on a user's body. Overall, this invention ensures medical professionals, firemen, emergency medical personnel, government workers, and so forth, are protected fully from contagious and infectious diseases, liquids, and so forth.
US10850138B2	Quick coupling for self-contained breathing apparatus harness and backplate Embodiments relate generally to connectors for use with harness and backplate systems in an SCBA. An SCBA may comprise a backplate for holding a cylinder of air and a harness with straps operable to attach to the backplate. Applicants have developed a backplate connector that provides a reliable quick connection and disconnection for straps attached to a backplate. The connector may fit into a slot on the backplate. In some embodiments, a plurality of connectors may be used to connect a plurality of straps to the backplate. Additionally, the connector may comprise a clip or other attachment operable to secure one or more hoses of the SCBA. This design may prevent the air hoses being hooked accidently, and the attachment of the hoses may help to secure the connector into the slot of the backplate, reducing the change of the connector disconnecting during normal usage.
US10850137B2	Method of reshaping a body part A method of reshaping a body part including the step of injecting a quantity of filler material into a subperiosteal plane of a facial region thereby depositing a body of filler between the periosteum and bone of the facial region. The method includes the step of piercing a periosteum of the facial region with a syringe. The method includes the step of drawing backwards a plunger of the syringe to ascertain whether a tip of a needle of the syringe is within a blood vessel. The filler may include a hyaluronic acid gel. The method of reshaping a body part includes the step of applying pressure to the body of filler to adjust a shape of the body of filler. The step of injecting is repeated in the following order of priority: first the temporal line of fusion, second the zygoma, third the malar, and fourth the jaw line.
US10850136B2	Moisturiser blend A blend for use in a personal care composition comprises a dialkyl amphiphilic component and an ester of a long chain branched fatty acid and a long chain branched alcohol. The blend can be pastillated and/or flaked, and can be used as the oil phase of an oil-in-water emulsion. The blend can be used in a moisturiser composition for moisturising skin.
US10850132B2	Particle therapy system A particle therapy system in which the efficiency of extracting a beam from a synchrotron can be improved and time required for therapy can be shortened is provided. The synchrotron 10 of the particle therapy system 100 extracts a charged particle beam, which circulates in the synchrotron 10, out of the synchrotron 10 by means of a slow extraction method using the resonance of a betatron oscillation, and magnetic poles 73 included in a bending magnet 12 of the synchrotron 10 have a SIM structure that generates a magnetic field distribution that makes the horizontal tune of the charged particle more closely approach a resonant line used in the slow extraction method as the amplitude of the horizontal betatron oscillation of a charged particle included in the charged particle beam becomes larger.
US10850131B2	Neutron source for neutron capture therapy A Boron neutron cancer treatment system has a moderator chamber filled with liquid or granular moderator material except for a central treatment chamber, the moderator chamber having parallel upper and lower surfaces, and a plurality of modular neutron generators fully immersed in the liquid or granular moderator material of the moderator chamber.
US10850128B2	Real-time, parallel x-ray tomosynthesis A device for performing tomosynthesis in real time is described. Multiple imaging sources (such as x-ray sources) may be energized in parallel and collimated towards a field of view. Objects within the field of view cast shadows onto one or more detectors. An imaging system may read the one or more detectors and acquire multiple views corresponding to the multiple imaging sources to produce a reconstructed image of an object of interest. From this reconstructed image, a target of the radiation therapy can be located, and the delivery of the radiation can be adjusted, as needed. The approach provides a real-time tomosynthesis design that can produce enhanced contrast for guidance of, for example, lung tumor treatment. Higher frame rates can be achieved to better compensate for changes in the position of the target during radiation therapy due to, for example, respiratory or cardiac motion.
US10850127B2	Charged particle beam therapy and magnetic resonance imaging The present invention provides a medical apparatus (100) comprising a magnetic resonance imaging system (110) for acquiring magnetic resonance data from an imaging volume (122) covering at least partially a subject of interest (120), wherein the magnetic resonance imaging system (110) comprises a main magnet (112) for generating a magnetic field within the imaging volume (122), a particle beam apparatus (150) having a particle beam line (152) for a particle beam (154) of charged particles, including a gantry (156) configured for rotating around a rotational axis (R), which is arranged in the longitudinal direction of the main magnet (112), wherein the gantry (156) comprises at least one bending magnet (158) for directing the particle beam (154) to an irradiation volume (124) within the imaging volume (122), an active compensation coil (200), which is arranged to substantially surround at least the imaging volume (122), and a control unit (132) for controlling the active compensation coil (200) for canceling a stray field caused by the at least one bending magnet (158) within the imaging volume (122) at least in the longitudinal direction of the main magnet (112). The present invention also provides a shielding method for use in the above medical apparatus (100).
US10850123B2	Treatment planning method, apparatus and radiotherapy system Provided in the present disclosure is a treatment planning method comprising, acquiring a preset dose distribution scheme; generating a plurality of radiation dose distribution schemes according to a preset algorithm and equipment parameters of a radiotherapy system, wherein the equipment parameters of a radiotherapy system comprises one or more of the radiation energy, parameters of radiation field, radiation angle, dose distribution at different radiation angles, and radiation time; comparing the plurality of radiation dose distribution schemes to the preset dose distribution scheme, to determine at least one radiation dose distribution scheme that is closest to the preset dose distribution scheme; and making a treatment plan according to the determined radiation dose distribution scheme.
US10850120B2	Selecting a dose prediction model based on clinical goals A clinical goal for radiation treatment of a patient is set. A dose prediction model is selected from a number of dose prediction models based on the clinical goal. A radiation treatment plan is then generated for the patient using the dose prediction model that was selected based on the clinical goal.
US10850119B2	Interactive computer-aided editor for compensators used in radiotherapy treatment planning When constructing compensators for radiation therapy using ion or proton radiation beams, a computer-aided compensator editing method includes overlaying an initial 3D compensator model on an anatomical image of a target mass (e.g., a tumor) in a patient, along with radiation dose distribution information. A user manipulates pixels or voxels in the compensator model on a display, and a processor automatically adjusts the dose distribution according to the user edits. The user iteratively adjusts the compensator model until the dose distribution is optimized, at which time the optimized compensator model is stored to memory and/or output to a machining device that constructs a compensator from the optimized model.
US10850118B2	Methods and devices for minim ally-invasive delivery of radiation to the eye Methods and devices for minimally-invasive delivery of radiation to the eye (such as the posterior portion of the eye) including cannula systems with multiple treatment positions and/or multiple channels in the distal tip of the cannula systems. The channels can accommodate emanating sources and exposing a target at various treatment positions. The emanating sources may be annulus-shaped.
US10850117B2	Sonoluminescent Biophysical Oscillation Techniques (SBOT) and method to improve health One or more devices, systems, and methods are described which together provide sonoluminescence biophysical oscillation technique(s) (SBOT(s)) that improve debilitated states of health for individuals comprising; biophysical oscillations that initiate, sustain, and/or control one or more sound emitting devices including speakers capable of providing harmonic and subharmonic sound and including music and/or individual musical notes that provide sound tracsons and one or more light emission devices including projectors that provide light wave emission traclums which are capable of imparting color changes, wherein tracsons and traclums provide auditory and visual stimuli that result in energy changes that create acoustic and tracson/traclum excitations. The tracson/traclum excitations are applied in an external manner to one or more bodies of humans and in some cases could be applied to animals.
US10850113B2	Cardiac electrical signal morphology and pattern-based T-wave oversensing rejection A medical device, such as an extra-cardiovascular implantable cardioverter defibrillator (ICD), senses R-waves from a first cardiac electrical signal by a first sensing channel and stores a time segment of a second cardiac electrical signal acquired by a second sensing channel in response to each sensed R-wave. The ICD determines morphology match scores from the stored time segments of the second cardiac electrical signal and, based on the morphology match scores, withholds detection of a tachyarrhythmia episode. In some examples, the ICD detects T-wave oversensing based on the morphology match scores and withholds detection of a tachyarrhythmia episode in response to detecting the T-wave oversensing.
US10850109B2	System and method of monitoring for and reporting on patient-made stimulation therapy programming changes A programmer is configured to effect communication with, and programming of, an implantable medical device configured to deliver neurostimulation therapy. The programmer comprises a display, such as touch screen display, and a processor comprising memory and coupled to the display. An interface is coupled to the processor and configured to receive therapy settings data indicative of current therapy settings operative in the implantable medical device and any modifications made to the therapy settings by a patient. The processor is configured to determine if one or more therapy settings have been modified since the last interaction with the patient, and coordinate displaying of the current therapy settings, the one or more therapy settings modified by the patient, and a previous state of the one or more therapy settings modified by the patient on the display.
US10850104B2	Implantable nerve stimulator having internal electronics without ASIC and methods of use An implantable pulse generator that includes a current source/sink generator is disclosed herein. The current source/sink generator includes a current drive differential amplifier. The current driver differential amplifier is configured to selectively source current to, or sink current from a target tissue. The current drive differential amplifier includes an inverting input and a non-inverting input. One of the inputs of the current drive differential amplifier is connected to a virtual ground, and the other is connected to a current command. A stimulation controller can supply a voltage to the other of the inputs of the current drive differential amplifier to select either current sourcing or current sinking.
US10850102B2	Method and apparatus for multimodal electrical modulation of pain Apparatus and methods for managing pain uses separate varying electromagnetic fields, with a variety of temporal and amplitude characteristics, which are applied to a particular neural structure to modulate glial and neuronal interactions as a mechanism for relieving chronic pain. In another embodiment, a single composite modulation/stimulation signal which has rhythmically varying characteristics is used to achieve the same results as separate varying electromagnetic fields. Also, disclosed is an apparatus and method for modulating the expression of genes involved in diverse pathways including inflammatory/immune system mediators, ion channels and neurotransmitters, in both the Spinal Cord (SC) and Dorsal Root Ganglion (DRG) where such expression modulation is caused by spinal cord stimulation or peripheral nerve stimulation using the disclosed apparatus and techniques. In one embodiment of multimodal modulation therapy, the prime signal may be monophasic, or biphasic, in which the polarity of the first phase of the biphasic prime signal may be either cathodic or anodic while the tonic signal may be either monophasic, or biphasic, with the polarity of the first phase of the biphasic tonic signal being either cathodic or anodic.
US10850093B2	Lead integrity monitoring A system for lead integrity monitoring includes an implantable medical device (IMD) having a housing enclosing a control circuit; and a lead, having a first sensor. The lead is coupled to the housing and electrically coupled to the control circuit. The system also includes at least one processing device configured to identify a first lead failure alert based on a first set of information; obtain a second set of information generated by a second sensor; perform an evaluation of the first set of information in the context of the second set of information; and confirm or cancel the first lead failure alert based on the evaluation.
US10850090B2	Devices and methods for controlling tremor A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The peripheral nerve stimulator can be either a noninvasive surface stimulator or an implanted stimulator. Stimulation can be electrical, mechanical, or chemical. Stimulation can be delivered using either an open loop system or a closed loop system with feedback.
US10850086B2	Medical connector A medical connector includes a male connector portion, an engagement portion, and a locking portion that slides on the engagement portion to set a locked state in which the engagement portion is inhibited from being pulled out of another medical connector when the male connector portion is inserted into a female connector portion of the other medical connector.
US10850081B2	Implantable bodily fluid drainage valve with magnetic field resistance engagement confirmation Verifying whether a magnetic field resistance mechanism is properly engaged in a drainage valve having an adjustable valve unit including a rotating construct and a pair of primary magnetic elements for programming the valve unit. Using a toolset, a determination is made whether the magnetic field resistance mechanism is properly engaged. An alert is generated whether the magnetic field resistance mechanism is at least one of properly engaged or not properly engaged based on: (i) a measured angular position of a detected one of the pair of primary magnetic elements relative to a direction of flow of fluid through the valve; and/or (ii) a measured distance separation between respective centers of the pair of primary magnetic elements.
US10850080B2	Electronic toolset to locate, read, adjust, and confirm adjustment in an implantable bodily fluid drainage system without recalibrating following adjustment A method of using an electronic toolset for locating, reading, adjusting and confirming adjustment of an implantable bodily fluid drainage system without requiring recalibration following adjustment from a current valve setting to a new valve setting using an electronic toolset including an adjustment tool having a magnetic element and an indicator tool including a sensor array. The need to remove the electronic toolset from the patient to recalibrate or zero the sensor array prior to confirming the new valve setting is eliminated. This is realized by disposing a ferromagnetic system component of the indicator tool in a magnet shield cage made of a metallic alloy to prevent magnetic fields produced by a magnetic element in the adjustment tool during the adjusting step from influencing the sensor array.
US10850078B2	Electrically-induced fluid filled balloon catheter The present disclosure relates generally to the use of medical devices for the treatment of vascular conditions. In particular, the present disclosure provides devices and methods for using electrically-induced pressure waves to disrupt vascular blockages. The present disclosure not only provides devices and methods for using electrically-induced pressure waves to disrupt vascular blockages, but the present disclosure also provides devices and method for assisting the guidewire in penetrating an occlusion, devices and method for using a sealable valve in the tip of the balloon catheter to reduce the overall size and diameter of the balloon catheter, thereby allowing the balloon catheter to penetrate smaller size blood vessels and devices. Given the persistence of coronary artery disease (CAD) and peripheral artery disease (PAD), there remains a need for improved therapeutic methods designed not only to reduce vascular blockages in the short term, but also to prevent future complications such as restenosis.
US10850076B2	Balloon catheters for body lumens Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.
US10850074B2	Guide wire A guide wire is disclosed, the guide wire including a flexible wire main body, a coil that is intermediately disposed in a longitudinal direction of the wire main body in an outer periphery of the wire main body, and a support portion that supports at least one of a distal end and a proximal end of the coil so as to be rotatable around a central axis O of the wire main body. In a natural state where an external force is not supplied to the guide wire, the support portion supports in a state where an inner peripheral portion of the coil and an outer peripheral portion of the wire main body are separated from each other.
US10850070B2	Intravenous catheter assembly with cannula safety mechanism A catheter assembly may include a catheter adapter that includes a distal end, a proximal end, and an inner surface forming a lumen. The lumen may extend between the proximal end and the distal end. The catheter assembly may also include a cannula and a cannula hub. The cannula hub may include an outer portion disposed outside of the catheter adapter and an inner portion disposed within the catheter adapter. The cannula may extend distally from the inner portion. In response to the outer portion sliding proximally along an outer surface of the catheter adapter, the cannula may be withdrawn proximally into the catheter adapter. The outer portion may be configured to slide proximally to a locked position in which the cannula hub is locked with respect to the catheter adapter, and a distal tip of the cannula is disposed within the catheter adapter.
US10850068B2	Catheter devices with valves and related methods Needle assemblies and related methods are disclosed having a needle hub with a needle, a catheter tube with a catheter hub and having the needle extending through the catheter tube; and a valve positioned in an interior cavity of the catheter hub, the valve having a first section with a first chord, a second chord, and a plurality of slits defining a plurality of flaps, a second section attached to the first section, and a third section attached to the first section; an inside edge formed on the second section and pressed against the first section; an inside edge formed on the third section and pressed against the first section; and wherein a first flow path is provided adjacent the first chord and a second flow path is provided adjacent the second chord.
US10850061B2	Lighting system for circadian control and enhanced performance Systems tune, control, or remediate the intrinsic Circadian clock. A light controller sets spectral distribution, intensity of a bioactive spectral band to shift or entrain circadian response to enhance performance and/or synchronize with local or expected conditions. The systems enhance performance under conditions that might be changing, disrupted, or otherwise present an irregular phase or unnatural change in the subject's circadian status, for example, due to geographically discontinuous activity or spectrally deficient workplace illumination, or due to divergent individual sleep/wake behaviors of subjects in a structured group activity. An illumination recipe that compensates for the deficiency of lighting or of participant sleep or behavior patterns, or age- or disease-related changes, to evoke, shift, or align circadian response and improve behaviors such as classroom alertness, relaxation, excitability, attention, or focus. Systems may receive sensed light values and automatically apply high- and/or low-CER illumination to effect the intended circadian phase.
US10850057B2	Cushion for a respiratory mask assembly A respiratory mask assembly for delivering breathable gas to a patient includes a frame and a cushion. The cushion has a non-face contacting portion structured to be connected to the frame, a face-contacting portion structured to engage the patient's face, and an intermediate portion that interconnects the non-face contacting portion and the face-contacting portion. The intermediate portion includes a gusset portion that applies a first component of force to the patient's face through the face-contacting portion. A spring structure is coupled with the face-contacting portion of the cushion. The spring structure applies a second component of force to the patient's face through the face-contacting portion. The first and second components of force applied by the gusset portion and spring structure, respectively, determine a contact force of the cushion applied to the patient's face through the face-contacting portion. The intermediate portion may also include an elastic cuff portion. Further, in the case of an oral mask, the sealing section may include a portion that is designed to promote a better seal in the chin region of the mask.
US10850050B2	Smart valved holding chamber A medication delivery system having a holding chamber capable of delivering dosages of medicament from a metered dose inhaler. The holding chamber includes an actuator detector, flow detector and display. In another embodiment, a medication delivery system includes a holding chamber having an input and an output end, a metered dose inhaler operably coupled to the input end of the holding chamber, and a metered dose inhaler identifier associated with the holding chamber and operable to identify the metered dose inhaler coupled to the holding chamber.
US10850046B2	Cannula locator device A cannula locator device is described herein. The cannula locator device may include a cannula. The cannula may include a distal tip, an elongated tubular shaft, and an inner lumen formed by the elongated tubular shaft. The cannula locator device may also include a first optical fiber configured to emit light and a second optical fiber configured to receive reflected light. The first and second optical fibers may be disposed within the inner lumen of the cannula. The first optical fiber may include a first distal end and a first proximal end. The second optical fiber may include a first proximal end and first distal end.
US10850045B2	Puncture injection instrument A puncture injection instrument including a hollow needle body including a substrate having a first surface and a second surface opposite to the first surface, the hollow needle body having one or more projections which are formed on the first surface and each have a through hole penetrating from a distal end of the projection to the second surface of the substrate, and one or more probes positioned outside a region where the one or more projections are formed. The one or more probes include an ultrasound probe or an optical coherence tomography probe.
US10850044B2	Safe auto-needle device The invention provides a safe auto-needle device for injection, comprising: a main housing and a syringe-support receiving a disposable prefilled syringe terminating in a needle covered by a needle sheath (NS). The speed of depressing of the syringe plunger is manually controllable by a user. In a first embodiment, a locking mechanism is present, for preventing premature advancement of the needle. A second embodiment comprises an interlock, for preventing depressing of a plunger, prior to advancement of the syringe-support to a needle penetration location. Additional components include a drive mechanism; and a needle shield moveable between: a needle covered position; a partially exposed position, to a fully extended needle safe position. The invention also discloses a needle sheath (NS) remover.
US10850043B2	Injection device The disclosure refers to a handheld injection device comprising a housing, a dose indicator positioned within and axially constrained to the housing and rotatable with respect to the housing during dose setting and during dose dispensing, a gauge element, which is at least partly interposed between the housing and the dose indicator, wherein the gauge element is axially guided within the housing and in threaded engagement with the dose indicator such that rotation of the dose indicator causes an axial displacement of the gauge element (80; 490). A contrast element having a first marking is provided and at least a region of the gauge element is provided with a second marking, with the first marking and/or the second marking being visible through a first window or aperture in the housing depending on the axial position of the gauge element within the housing.
US10850042B2	Three-position plungers, film coated plungers and related syringe assemblies A three-position plunger is provided including a sleeve having an opening at a distal end, a pre-load cavity proximal to and in communication with the opening, a first cavity proximal to and in communication with the pre-load cavity, a second cavity proximal to and in communication with the pre-load cavity, and at least one rib. The rib(s) is generally aligned with the first cavity. The plunger further includes an insert configured to be displaced from the pre-load cavity to the first cavity and from the first cavity to the second cavity. The insert is configured to provide support for the compression of the rib(s) when the insert is positioned in the first cavity.
US10850040B2	Syringe-type ejector The syringe dispenser includes a syringe and a plunger. The plunger includes a first shaft member including a piston and second shaft member configured to be fitted in a tubular portion of the first shaft member. The first shaft member includes an elastic piece, the elastic piece being provided with a slide projection configured to slide on an inner surface of the syringe and a lock projection configured to be locked against the syringe. The second shaft member includes a pressing shaft configured to be fitted in the tubular portion. The pressing shaft is provided in a front end thereof with an end surface configured to press a free end of the elastic piece. In response to pressing from the end surface, the lock projection is locked against the rear end of the syringe, and in response to the pressing being released, the locking of the lock projection is released.
US10850039B2	Drive assembly for a drug delivery device and drug delivery device comprising a drive assembly A drive assembly for a drug delivery device includes a spring member, a piston rod and a piston rod nut being engaged with the piston rod. The piston rod nut is configured to rotate and axially move during dose setting. The spring member is compressed when the piston rod nut is moved during the dose setting. The piston rod nut is rotationally fixed during dose dispensing.
US10850035B2	Auto-injector device An injection device comprises an injector body having at least one indicator aperture; a medicament reservoir disposed within the injector body; a piston; and one or more status indicators. A movement of the piston expels a medicament out of the medicament reservoir, and operates to move at least one of the one or more status indicators relative to a corresponding indicator aperture.
US10850032B2	Device for administering a fluid product An infusion apparatus for delivering medication includes a housing, a drive mechanism, a force sensor, and a transfer element. The drive mechanism comprises first and second conveying elements, the second conveying element for advancing a plug in a reservoir in the distal direction, the first conveying element with limited axial movement relative to the housing but rotatable to cause an ejecting or resetting movement of the second conveying element. The force sensor is arranged along a central axis between the housing and the proximal end of the drive mechanism. The transfer element is axially arranged between the force sensor and the first conveying element and the force sensor bears axial forces exerted by the ejection movement. The second conveying element moves the transfer element away from the first conveying element against the bias of a restoring force such that the force sensor bears axial forces exerted by the resetting movement.
US10850030B2	Flow rate control device for supplying liquid chemical Provided is a flow rate control device for supplying liquid chemicals. The device according to an embodiment of the present disclosure includes a housing unit which is placed at the location from which liquid chemicals are supplied and comprises an inflow conduit on one side to which the liquid chemicals flow in and an outflow conduit from which the flowed-in liquid chemicals whose flow rate is controlled flow out; and a control unit which is integrated with the housing unit and comprises an inflow space which comes in contact with an inflow hole at a terminal portion of the inflow conduit, an outflow space which comes in contact with an outflow hole at a terminal portion of the outflow conduit and a control path which is connected between the inflow space and the outflow space to control the flow rate of the flowed-in liquid chemicals, wherein the control path has a controlled inner diameter and a controlled length according to the flow rate a user aims at.
US10850025B2	Arrayed multi-IV set management device A multi-IV set retention device for retaining flexible lines (e.g., medical fluid lines, such as IV sets) comprises a retention body having a normal axis, and a plurality of retention slots that removably receive and retain flexible lines, and a plurality of openings to facilitate insertion of a flexible line into an associated retention slot. The retention slots are radially arrayed about the normal axis of the retention body, such that the plurality of flexible lines is movable as a unitary body. The flexible lines can be radially bundled as a collection of flexible lines that define a center of mass about a central portion of the retention device, so that the flexible lines move and act as a single flexible line. One or more of such multi-IV set retention devices can be coupled along a length of one or more flexible lines, thus fanning an IV set retention system. A method of making the multi-IV set retention device, and a method of retaining flexible lines, is provided.
US10850022B2	Separating and transferring phases of a fluid through centrifugation A system for separating and transferring phases of a fluid through centrifugation including a centrifuge having a rotating axis, a platform that is rotatable around the rotating axis; and a device for separating and transferring the phases of the fluid. The device includes a separating container and a receiving container connected to the separating container through a connecting channel. A passive valve system is provided in the connecting channel. The device is mounted in the centrifuge platform such that in use at a first predefined range of centrifugal force a fluid provided within the separating container is separated into phases and at a second predefined range of centrifugal force the valve system opens, thereby transferring a phase of the fluid from the separating container to the receiving container.
US10850020B2	Dialysis machine support assemblies and related systems and methods In some aspects, a dialysis machine support assembly includes a platform configured to support a dialysis machine and a drive assembly configured to move the platform vertically.
US10850016B2	Modular fluid therapy system having jumpered flow paths and systems and methods for cleaning and disinfection Systems and methods for cleaning and disinfecting a medical therapy device that delivers any one of hemodialysis, hemodiafiltration and hemofiltration. The system has a base module that has at least one segment of a controlled compliant flow path and at least one pair of jumpered ports configured on the base module. One or more components have connections connectable to the jumpered ports of the base module to provide for fluid communication between the segment of the controlled compliant flow path in the base module and a flow path defined by the one or more components. The base module is connected to the one or more components that define a flow path configurable for carrying out in part at least one function performed during any one of hemodialysis, hemodiafiltration or hemofiltration.
US10850015B2	Systems and methods for therapeutic platelet depletion Systems and methods are provided for depleting platelets from blood. The system includes a multi-stage blood separation chamber in which blood is separated into red blood cells and platelet-rich plasma. The platelet-rich plasma is conveyed from a first stage of the chamber to a second stage, where it is separated into platelets and platelet-poor plasma. The platelet-poor plasma is conveyed out of the chamber while the platelets are allowed to accumulate in the second stage of the chamber. When a controller of the system has determined that the maximum chamber capacity of platelets has been accumulated in the second stage of the chamber, the platelets are conveyed out of the chamber to a waste container. The cycle of separating blood into its components, accumulating platelets in the chamber, and then flushing the platelets from the chamber is repeated until a target platelet concentration of the blood is achieved.
US10850014B2	Liquid collection device and method A liquid collection device for use in drawing liquid from an opening in a body of a person or an animal. The device includes a perforated container, and an outlet port. The perforated container defines a chamber shaped to collect liquid drawn into the chamber through perforations in the container. The outlet port enables liquid to be drawn from the chamber by a partial vacuum applied at the outlet port. The container is configured to receive wicking material that covers at least some of the perforations and is also configured and dimensioned for placement of the wicking material in, or over approximately an exposed breadth of, an opening in a person or an animal, so that upon said placement of the container with at least some of the perforations being covered by said wicking material, when a partial vacuum is applied at the outlet port, liquid can be drawn from said opening through the wicking material and into the chamber and from the chamber through the outlet port.
US10850013B2	Directed fluidics Methods and systems for administering directed fluidics during a medical procedure for removing an object are disclosed. A method includes inserting first and second medical instruments into a treatment site, providing irrigation and aspiration of the treatment site through the first and second medical instruments, determining a characteristic of one of the irrigation and the aspiration, and selecting a characteristic of the other of the irrigation and aspiration based on the determined characteristic.
US10850001B1	Sterilizing mechanism An air sterilizing apparatus is created which can be set within an environment without adversely affecting people, pets, or plants within the environment such as a room. The apparatus uses a passage through which ambient air passes. The passage has a treatment chamber in which ultraviolet light (ideally UV-C) is used to sterile the ambient air. Each end section of the passage is configured to block light from exiting the passage. In the preferred embodiment, each end section includes a coating of UV adsorbing material to provide further protection to the environment from the UV light.
US10849999B2	Method for disinfecting pressurized assisted breathing machines and maintaining said machine's air quality A method for disinfecting a contaminated pressurized assisted breathing machine, namely a sleep apnea machine including said machine's components and maintaining said machine's fluid quality between use on patients, which comprises the steps of preparing an aqueous solution comprising alcohol-glycerin-chlorhexidine gluconate-dye-flavoring agent; purging and removing machine's existing fluid from said machine and said machine's components; introducing the said aqueous solution into said machine and said machine's components; purging with pressurized fluid by removing said aqueous solution and contaminants from said machine and said machine's components; introducing pressurized fluid into said machine and said machine's components for flushing and rinsing said machine and said machine's components.
US10849996B2	Storage device including ultraviolet illumination Ultraviolet radiation is directed within an area. Items located within the area and/or one or more conditions of the area are monitored over a period of time. Based on the monitoring, ultraviolet radiation sources are controlled by adjusting a direction, an intensity, a pattern, and/or a spectral power of the ultraviolet radiation generated by the ultraviolet radiation source. Adjustments to the ultraviolet radiation source(s) can correspond to one of a plurality of selectable operating configurations including a storage life preservation operating configuration, a disinfection operating configuration, and an ethylene decomposition operating configuration.
US10849994B2	Pharmaceutical composition comprising fluorine-18 labelled gases There is provided a process for the preparation of a pharmaceutical composition comprising an 18F-labelled gas selected from the group consisting of 18F-labelled sulphur hexafluoride ([18F]SF6) and 18F-labelled carbon tetrafluoride ([18F]CF4), comprising the steps: a) Filling a target with a gas mixture comprising a fluorinated gas selected from the group consisting of sulphur hexafluoride (SF6) and carbon tetrafluoride (CF4); b) Irradiating the gas mixture of step a) with protons with energies from 0.1 to 50 MeV. The pharmaceutical composition obtainable by the process and its uses in diagnosis, prognosis and lung function studies based on positron emission tomography (PET) are also claimed.
US10849991B2	Gene therapy for the treatment of a disease of retinal cone cells The present invention relates to a polynucleotide configured for the treatment of a disease of retinal cone cells, such as achromatopsia, a nucleic acid vector comprising said polynucleotide, a pharmaceutical composition comprising said nucleic acid vector, a kit comprising said polynucleotide or said nucleic acid vector, a method of making said nucleic acid vector, and a method for treating a disease of the retinal cone cells.
US10849986B2	Antibody-drug conjugates and uses thereof The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an antibody or antigen-binding antibody fragment. The antibody may bind to Trop-2 or CEACAM5 and the immunoconjugate may be administered at a dosage of between 4 mg/kg and 16 mg/kg, preferably 4, 6, 8, 9, 10, 12, or 16 mg/kg. When administered at specified dosages and schedules, the immunoconjugate can reduce solid tumors in size, reduce or eliminate metastases and is effective to treat cancers resistant to standard therapies, such as radiation therapy, chemotherapy or immunotherapy. Surprisingly, the immunoconjugate is effective to treat cancers that are refractory to or relapsed from irinotecan.
US10849985B2	Method of targeting senescent cells A method of targeting a pharmaceutical agent to a senescent cell is disclosed. The method comprises administering the pharmaceutical agent to the subject, wherein said pharmaceutical agent is attached to an affinity moiety, said affinity moiety being capable of binding specifically to a polypeptide selected from the group consisting of HSP90B1, DNAJB4, PI4K2A, DBN1, PRKCSH, SPTBN1, NPM1, ITGA3 and a polypeptide set forth in Table 1. The targeting may be for therapeutics or diagnostics.
US10849983B2	Development of soluble albuminated curcumin for application in cancer therapy This invention relates to an albumin-curcumin conjugate for application in cancer therapy, including albumin and curcumin.
US10849978B2	Pharmaceutical composition for administration to nasal mucosa The present invention is intended to provide a nose drop having high absorption of peptide hormone oxytocin or an acid addition salt thereof, or a derivative thereof through nasal mucosa and little safety concern. The present invention is a pharmaceutical composition for administration to nasal mucosa containing oxytocin or an acid addition salt thereof, or a derivative thereof and a carboxyvinyl polymer, characterized by having an osmotic pressure ratio less than 1.
US10849977B2	Liquid Protein Formulations Containing Thiamine Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous or intramuscular injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, and viscosity-lowering agents that are typically bulky polar organic compounds, such as many of the GRAS (US Food and Drug Administration List of compounds generally regarded as safe) and inactive injectable ingredients and FDA approved therapeutics.
US10849965B2	H3.3 CTL peptides and uses thereof Peptides that generate an immune response to glioma-related H3.3 proteins and methods of their use are provided.
US10849960B2	Synergistic combination of IL-4, interferon gamma, and interferon alpha in treating ovarian cancer Methods and compositions are disclosed for treating a subject with a cancer. The compositions can include a chimeric molecule comprising an agent that specifically binds the interleukin 4 receptor (IL-4R) and a toxic moiety, an interferon alpha (IFNα), and an interferon gamma (IFNγ). In some non-liming embodiments, the compositions can also include monocytes. The methods disclosed herein include administering a therapeutically effective amount of the compositions taught herein to a subject with cancer, thereby treating the cancer in the subject, wherein cells in the cancer express IL-4R. In some non-liming embodiments, the methods can also include administering monocytes.
US10849958B2	Knee pain evaluation and management via WOMAC and KOOS systems Knee pain evaluation and management is carried out via intra-articular injections into a patient suffering from knee pain with the injection being comprised of water and a particularly defined peptide. After injection, knee pain is evaluated using a pain subscale such as Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) or Knee injury and Osteoarthritis Outcome Score (KOOS).
US10849956B2	Glycopeptide compositions Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.
US10849955B2	Methods of treating pancreatic cancer using GPCR antagonists Provided herein are, inter alia, compositions and methods for the treatment of cancer and inhibition of metastasis. The compositions include a μ-opioid receptor (MOR) polypeptide and a somatostatin receptor 2 (SSTR2) polypeptide, wherein the MOR polypeptide is bound to a MOR antagonist and the SSTR2 polypeptide is bound to a SSTR2 antagonist. The compositions and methods provided herein are, inter alia, useful to treat pancreatic cancer.
US10849953B1	Food supplement to alleviate symptoms of Parkinson's disease A food supplement to reduce symptoms of Parkinson's disease is disclosed. The food supplements contains a mixture of garlic, almond, peanut, tomato, grape, clove, black eye pea turmeric, tea and velvet bean.
US10849950B2	Composition for treating fatty liver A composition for treating fatty liver which comprises extracts of ginseng, Atractylodes rhizome, Crataegus cuneate, Alisma tuber and Cassia obtusifolia L.
US10849947B2	Feed supplement and a feed composition comprising resin acid based composition The present invention relates to a feed supplement which comprises a resin acid based composition comprising over 10% (w/w) resin acids for use in the prevention of growth of harmful bacteria in the animal digestive tract, in the prevention of intestinal disorders, in the modulation of microbial population of the animal digestive tract, in enhancing rumen fermentation, lowering rumen methane production and/or in binding toxins. The invention further relates to a use of the feed supplement and a feed composition comprising the feed supplement.
US10849946B2	Genetically engineered vaccinia viruses The present invention provides a genetically recombinant vaccinia virus effective in preventing or treating cancer. Specifically, the present invention provides a vaccinia virus comprising two polynucleotides, a polynucleotide encoding IL-7 and a polynucleotide encoding IL-12; a combination kit of two vaccinia viruses, a vaccinia virus comprising a polynucleotide encoding IL-7 and a vaccinia virus comprising a polynucleotide encoding IL-12; and use of the two vaccinia viruses in combination.
US10849945B2	Oncolytic adenovirus encoding a B7 protein or active fragment The present disclosure provides a replication competent oncolytic adenovirus with selectivity for cancer cells, wherein the adenovirus comprises a transgene under the control of a promoter endogenous to the virus, wherein the transgene comprises a DNA sequence encoding a B7 protein or an active fragment thereof, compositions comprising same, methods of generating the viruses, and use of the viruses and compositions in treatment, particularly in the treatment of cancer.
US10849942B2	Treatment of bacterial infections in aquaculture A composition comprises bacteriophage covalently attached to an edible particle and is for use in treating bacterial infection in fish or crustaceans. Infections in fish or crustaceans caused by Vibrio, Aeromonas, Yersinia, Moritella, Rickettsia, Piscirickettsia, Lactococcus, Pseudomonas, Flavobacterium or Photobacterium bacteria species can be treated. Bacteria infected with a lysogenic bacteriophage are used for treating disease of fish or crustaceans caused by similar infections by bacteria carrying lysogenic bacteriophage that express a toxin gene.
US10849939B2	Probiotic formulation A probiotic organism which is capable of proliferation in iron-rich media, an environment which is generally unfavourable to probiotic organisms, is described.
US10849938B2	Gene expression system for probiotic microorganisms Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.
US10849934B2	Compound and preparation method thereof Disclosed is a compound, prepared by extracting and separating from Limax. Also disclosed is a method for extracting and separating the compound, which is simple and easy to operate. The compound has sedative and hypnotic effects, and has significant effects on physiological or psychological dependent detoxification or detoxication. It has potential application value for preparing detoxification or detoxication drugs, and provides new ideas for the further development of detoxification drugs.
US10849931B2	Compositions and methods for platelet enriched fibrin constructs Compositions and methods are provided for tissue constructs that promote wound healing. The composition comprises a dimensionally stable fibrin construct for local administration to a wound site or region. In one embodiment, the fibrin construct is a wound healing composition, including components that promote wound healing, such as platelets, growth factors, white blood cells and fibrin clots. In another embodiment, the tissue treatment composition includes (i) aggregated fibrin, (ii) blood cells, and (iii) optionally, growth factors and/or other proteins.
US10849930B2	Composition for promoting increase in subcutaneous tissue and subcutaneous adipose tissue In particular, a composition for breast augmentation that includes a composition promoting an increase in subcutaneous tissue, wherein the promoting composition aims at accumulating and increasing adipose tissue under the skin of a breast by generating and increasing the adipose tissue around a mammary gland and enables recovery of autologous tissue and recovery of appearance by a safe and natural process, and a method for breast augmentation are provided. A composition promoting an increase in subcutaneous tissue that contains autologous plasma and a basic fibroblast growth factor (b-FGF), in particular, a composition for breast augmentation is provided. A composition for breast augmentation that includes the above-described composition promoting an increase in subcutaneous tissue that further contains fat is provided. Specifically, a composition for breast augmentation that includes the above-described composition promoting an increase in subcutaneous tissue, wherein the fat is in the form of a lipid emulsion and the lipid emulsion is an oil-in-water lipid emulsion produced by emulsifying fat and oil in the presence of an emulsifier, and a method for breast augmentation by using the composition are provided. An injection unit of the composition for breast augmentation is also provided.
US10849921B2	Pharmaceutical composition comprising particles comprising a complex of a double-stranded polyribonucleotide and a polyalkyleneimine The present invention relates to compositions comprising complexes that are formed by polyinosinic-polycytidylic acid with a polyalkyleneimine, such as polyethyleneimine, that present uniform structural and functional features, as well as to processes for the preparation of said compositions that comply with regulatory requirements. The present invention additionally relates to use of said compositions as medicaments (in particular for treating cancer), alone or in combination with other therapeutic agents and/or in specific medical methods. Moreover, the administration of these compositions is associated to changes in the expression of specific genes, in cell responses, and/or in composition of immune cell populations that can be used as specific biomarkers and/or as additional target for medical treatment.
US10849911B2	Low dose compositions of Aramachol salts The present invention relates to salts of arachidyl amido cholanoic acid (Aramchol), pharmaceutical compositions comprising Aramchol salts, methods for their preparation, and methods of use thereof in medical treatment.
US10849909B2	Antibiotic compositions for nasal irrigation and methods Provided herein are pharmaceutical formulations, nasal irrigation fluids, sachets, kits and the like comprising cephalosporin antibiotics, as well as methods of topical treatment of sinusitis and related conditions, methods of delivery of the formulations and fluids to the sinuses, methods of coating the sinuses, and methods of disruption and/or penetration of biofilms in the sinuses.
US10849907B2	Imidazopyridine derivatives and the use thereof as medicament The present invention relates to imidazopyridines of formula A processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment or prevention of conditions having an association with NR2B negative allosteric modulating properties.
US10849902B2	Medicament for treating heart failure The present invention provides a medicament for preventing or treating heart failure. More specifically, the present invention provides a medicament for preventing or treating heart failure, comprising a compound selected from the group consisting of (5R)—N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, (5R)—N-[1-ethyl-1-(4-methoxyphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, (5R)—N-[1-ethyl-1-(4-ethylphenyl)propyl]-5-(2-fluorophenyl)-2,7,7-trimethyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and salts thereof.
US10849898B2	Treatment of relapsed and/or refractory solid tumors and non-Hodgkin's lymphomas Methods are provided for the treatment of relapsed and/or refractory solid tumors (including neuroendocrine carcinomas (NEC)) and non-Hodgkin's lymphomas (NHLs) and the like, using substituted heterocyclic derivative compounds and pharmaceutical compositions comprising compounds useful for the inhibition of lysine specific demethylase-1 (LSD-1).
US10849894B2	Aripiprazole prodrug composition Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm and (b) at least one surface stabilizer comprising an adsorbed component which is adsorbed on the surface of the aripiprazole prodrug particles and a free component available for solubilisation of the aripiprazole prodrug. The surface stabilizer to prodrug ratio provides the optimal quantity of free surface stabilizer for the purposes of producing a lead-in formulation. Also described are methods of treatment using the aforementioned composition.
US10849889B2	Methods of treating Fabry patients having renal impairment Provided are methods for treatment of Fabry disease in patients having HEK assay amenable mutations in α-galactosidase A. Certain methods comprise administering migalastat or a salt thereof every other day, such as administering about 150 mg of migalastat hydrochloride every other day.
US10849887B2	Treatment of Parkinson's disease The invention relates to a method of treating or preventing Parkinson's disease in a subject comprising administering a compound of Formula I wherein, R1 is —NHC(O) C3-6 cycloalkyl and R2 is hydrogen; or R1 and R2 along with the carbon atoms to which they are attached form a six membered aromatic ring, wherein the ring is substituted with one or more groups selected from hydrogen, halogen and C1-6 alkyl; R3 and R4 are independently selected from group comprising hydrogen, halogen, C1-3 alkyl, OC1-3 alkyl, NO2, SC1-3, alkyl, C1-3, haloalkyl, OC1-3 haloalkyl, and SC1-3 haloalkyl; or a pharmaceutically acceptable salt thereof.
US10849885B2	Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy The present invention relates to specific doses of and dosing regimens for using a 1,2,4-oxadiazole benzoic acid compound in treating or preventing diseases associated with nonsense mutations. In particular, the invention relates to specific doses and dosing regimens for the use of 3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid in mammals having diseases associated with nonsense mutations.
US10849883B2	Benzopyrazole compounds and analogues thereof Disclosed are compounds of formula I, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising a compound of formula I, and methods involving use of the compounds and compositions in the treatment and prevention of diseases and conditions characterized by aberrant complement system activity.
US10849882B2	Use of carbamate compound for preventing or treating fibromyalgia or functional syndrome associated with fibromyalgia The present invention relates to a pharmaceutical composition for preventing or treating fibromyalgia or a functional syndrome associated with fibromyalgia, the pharmaceutical composition comprising: a carbamate compound of chemical formula 1 or a pharmaceutically acceptable salt thereof, a solvate or a hydrate; and a pharmaceutically acceptable carrier. The pharmaceutical composition, according to the present invention, may enable the efficient treatment of fibromyalgia or a functional syndrome associated with fibromyalgia.
US10849879B2	Localized modulation of tissues and cells to enhance therapeutic effects including renal denervation Pharmaceutical preparations, compositions, systems, and devices including medical devices and diagnostic or therapeutic agents, and methods to treat disease by modification of local tissue environment to modulate the therapeutic index of locally or systemically delivered therapeutic or diagnostic agents. Improved ability to reduce sympathetic nerve activity in the adventitia and perivascular tissues around arteries and veins in the body. Modulation of the local tissue environment around an artery to enable more effective denervation with or without a therapeutic agent. Modulation may include adjustment of the pH of the tissue.
US10849878B2	Agent exhibiting anti-stress, anxiolytic and anti-depression activity, and composition based thereon The agent with antistress, anxiolytic and antidepressant activity and a composition based on it. The invention relates to the field of pharmaceutics, particularly to chemical compounds based on lithium salts, namely to substances with antistress, anxiolytic and antidepressant activity and can be used in medicine, veterinary medicine, and the pharmaceutical industry. The invention discovers the possibility of using lithium ascorbate as an agent with antistress, anxiolytic and antidepressant activity. The claimed composition with antistress, anxiolytic and antidepressant activity, including a lithium salt, contains pyridoxine hydrochloride, thiamine mononitrate and lithium ascorbate as a lithium salt. The use of lithium ascorbate as an agent with antistress, anxiolytic and antidepressant action and the composition based on it, enables to expand the assortment of the agents for indicated administration. At the same time, the claimed agents have low toxicity and high efficacy.
US10849875B2	Cancer specific lipid targeted peptidomimetics A phosphatidylserine targeted peptoid has been identified with the ability to bind to cancer cells globally and specifically. A dimer of the peptoid decreases cancer cell viability. Use of the dimerized peptoid enhances the efficacy of docetaxel. The peptoid can be used for including but not limited to diagnosing and treating cancer, diagnosing and treating a viral condition, and diagnosing and treating diabetes.
US10849874B2	Use of composition for modulating angiogenesis The present invention relates to a method for modulating angiogenesis in a subject in need thereof, which comprises administering an effective amount of composition comprising excavatolide B and a pharmaceutically acceptable carrier to the subject.
US10849872B2	Methods and compositions for treating obesity, preventing weight gain, promoting weight loss, promoting slimming, or treating or preventing the development of diabetes The present invention relates to compositions and kits including a chemical uncoupler, such as tyrphostin 9 or precursor or a salt thereof, and compositions including a chemical uncoupler, such as tyrphostin 9 in combination with one or more therapeutic agents, for example, L-carnitine, which are useful, for example, in treating obesity, preventing weight gain, promoting weight loss/slimming, and/or treating or preventing the development of diabetes.
US10849871B2	Compositions and methods of use of phorbol esters for the treatment of stroke Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects.

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