最新美国发明专利第2016-09-20期 - 专利汇|PatentHub专利检索|专利查询网|发明专利查询分析

Document	Document Title
US09447418B2	Pro- and anti-angiogenic treatments The invention provides a method of selectively pro-oranti-angiogenic treatment of a mammalian subject, comprising site-specific control of alternative splicing during processing of VEGF pre-mRNA transcribed from the C terminal exon 8 of the VEGF gene using controlling agents for the splicing, wherein one or more controlling agent which favors proximal splice site (PSS) splicing in said processing is used in the pro-angiogenic treatment and one or more controlling agent which favors distal splice site (DSS) splicing in said processing is used in the anti-angiogenic treatment.
US09447413B2	Oligomeric compounds and compositions for use in modulation of small non-coding RNAs Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
US09447410B2	T cell receptor display A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.
US09447404B2	Method for the biocatalytic cyclization of terpenes and cyclase mutants employable therein The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
US09447403B2	Enolase peptide conjugate vaccines against Staphylococcus aureus The present invention relates to peptides of the enolase protein from Staphylococcus aureus as well as nucleic acid and nucleic acid sequence homologs encoding the peptides. The present invention also relates to a composition, particularly a S. aureus vaccine, comprising one or more of the enolase peptides described herein or a fragment, derivative or variant thereof capable of generating an immune response that induces a protective antibody response or opsonophagocytic activity of human neutrophils for S. aureus. The present invention also encompasses methods of treating and/or reducing the likelihood of a Staphylococcus infection by administering a composition of the invention.
US09447402B2	Method for producing recombinant prothrombin, vector DNA, and reagent kit The present invention provides a method for producing recombinant prothrombin. The method comprises: providing a vector DNA into which a gene encoding a tag and a gene encoding prothrombin are incorporated, wherein the tag is selected from the group consisting of MBP, SUMO, and NusA; and expressing a tag fusion type prothrombin in a lepidopteran insect or cultured cells of the lepidopteran insect.
US09447401B2	PH20 polypeptide variants, formulations and uses thereof Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
US09447399B2	Polypeptides having cellobiohydrolase I activity and polynucleotides encoding same The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.
US09447398B2	Heterologous expression of fungal cellobiohydrolase 2 genes in yeast The present invention provides for heterologous expression of polypeptides encoded by wild-type and codon-optimized cbh2 genes from the organisms Cochliobolus heterostrophus, Gibberella zeae, Irpex lacteus, Volvariella volvacea, and Piromyces sp. in host cells, such as the yeast Saccharomyces cerevisiae. The expression in such host cells of the corresponding genes, and variants and combinations thereof, result in improved specific activity of the expressed cellobiohydrolases. Thus, such genes and expression systems are useful for efficient and cost-effective consolidated bioprocessing systems.
US09447396B2	Method for accumulating protein in plant cells According to the present invention, a method for stably accumulating a target protein in plant cells or a plant body, and a transgenic plant in which protein has accumulated, are provided. The method of the present invention is a method for accumulating protein in plant cells, comprising accumulating a target protein or a protein deficient in an N-terminal region of the target protein in vacuoles of myrosin cells present in a multiple mutant, in which myrosin cells deficient in intravacuolar protein are also present in a plant body at locations other than around vascular bundles, by expressing a gene that encodes a target protein having an intracellular membrane system localization signal on the N-terminal and a vacuole localization signal on the C-terminal in the multiple mutant.
US09447388B2	DNA polymerases Provided are various novel DNA polymerases. Provided is a DNA polymerase comprising an amino acid sequence modified from the amino acid sequence of SEQ ID NO: 8 by inserting nine amino acids “-A737-A738-A739-A740-A741-A742-A743-A744-A745-” between the amino acid residue at position 736 and the amino acid residue at position 737,wherein: A737 is an amino acid residue having a non-polar aliphatic side chain; A738 is an amino acid residue having a non-polar aliphatic side chain; A739 is an amino acid residue having a positively charged side chain; A740 is an amino acid residue having a positively charged side chain; A741 is an amino acid residue having a non-polar aliphatic side chain; A742 is an amino acid residue having a non-polar aliphatic side chain; A743 is any given amino acid residue; A744 is an amino acid residue having a positively charged side chain; and A745 is an amino acid residue having a non-polar aliphatic side chain).
US09447377B2	Endodermal cells from pluripotent cells The present inventions describes a method that, starting from pluripotent cells, leads to the obtainment, in a reproducible and efficient manner, of endodermal cells precursor. These cells reveal useful also for application in the regenerative therapy.
US09447376B2	Dried spore germinative compound mixtures In one aspect, the present invention is directed to a dried intimate mixture comprising a bacteria spore and a germinative compound, and methods for preparing the intimate mixture. In another aspect, this invention is directed to a composition comprising such an intimate mixture. The invention also relates to methods for increasing the germination, growth, metabolism, and/or enzyme activity of a bacteria spore comprising preparing an intimate mixture of a bacteria spore and a germinative compound.
US09447373B1	Methods for treating a culture of haematococcus pluvialis for contamination using salt and hydrogen peroxide Methods of treating contamination, particularly fungal contamination, in cultures of Haematococcus pluvialis with hydrogen peroxide and salt are described herein. The method comprises dosing the culture comprising a concentration of salt with a concentration of hydrogen peroxide based on the stage of the cells in the culturing process and at a frequency to increase the likelihood of the cells surviving until the process of accumulating carotenoids, such as astaxanthin, is complete.
US09447372B2	Detector arrangement for blood culture bottles with colorimetric sensors A detector arrangement is disclosed for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or CO2 of a sample medium within the blood culture bottle. The detector arrangement includes a sensor LED illuminating the colorimetric sensor, a reference LED illuminating the colorimetric sensor, a control circuit for selectively and alternately activating the sensor LED and the reference LED, and a photodetector. The photodetector measures reflectance from the colorimetric sensor during the selective and alternating illumination of the colorimetric sensor with the sensor LED and the reference LED and generates intensity signals. The reference LED is selected to have a peak wavelength of illumination such that the intensity signals of the photodetector from illumination by the reference LED are not substantially affected by changes in the color of the colorimetric sensor.
US09447370B2	Distilled liquors and spirits having the fresh and natural fragrance of shiso and processes for producing the same Provided are liquors or spirits that compensate for the oily and grass-like smell of perillaldehyde, the primary aroma component of Perilla frutescens var. crispa (shiso), to ensure that the fresh and natural fragrance of shiso is developed in a balanced way. In the process of making distilled liquors or spirits, the temperature of the distillation feed charged into a distillation vessel is managed appropriately, whereby the aroma components of shiso used as part of the feed can be recovered in a balanced way to produce distilled liquors or spirits having the fresh and natural fragrance of shiso. According to the distillation method of the present invention, no extra equipment investment is required and distilled liquors or spirits of good quality can be obtained with a minimum production cost.
US09447364B2	Fragrance compounds A method of providing a fragrant odor to an application, comprising the addition thereto of at least one compound of the formula I wherein X and Y are independently selected from the group consisting of —CR1R2R3, —NR4R5 and —OR6, wherein R1 to R5 are selected from H and essentially hydrocarbon moieties that optionally comprise at least one oxygen, nitrogen or silicon atom, and R6 is selected from essentially hydrocarbon moieties that optionally comprise at least one oxygen, nitrogen or silicon atom; and, A is an essentially hydrocarbon moiety that optionally comprises at least one oxygen, sulphur, nitrogen or silicon atom, with the proviso that the compound A-CHO is a fragrant aldehyde. The use of these compounds in laundry, household and personal care products confers a long-lasting freshness.
US09447362B2	Nitrile compound Provided are a compound and a fragrance composition containing the same, wherein the compound has a spicy tone that is useful as a fragrance, particularly a cumin-like odor, it is stable in an aqueous vehicle, and it emphasizes spicy-, green-, floral-, woody-, and citrus-like various odors by being blended with other fragrances, which allows oil-, chemical-, and metallic-like undesirable odors to be suppressed. A nitrile compound represented by Formula (I-3), Formula (I-2), or Formula (I-1).
US09447360B2	Removal of undesired components from oil compositions The present invention refers to a process for reducing the amount of undesired components in an oil composition, particularly in an oil composition comprising omega-3 polyunsaturated fatty acids. The process of the present invention provides efficient removal of undesired water-soluble (hydrophilic) components and undesired fat-soluble (lipophilic) components from an oil composition in order to obtain a purified concentrate, e.g. a highly purified concentrate enriched in omega-3 polyunsaturated fatty acids.
US09447356B2	Diesel fuel with improved ignition characteristics Dihydrocarbyl diazene dicarboxamides (DHCDD) have been found to effectively reduce the ignition delay and/or as effective cetane number improvers in diesel fuels and is suitable for use in modern engines.
US09447354B2	Spent grain fuel product and process A process of making a fuel product from spent grain from a beer brewing process. In the brewing process, the grain is pulverized to a particle size whose mean particle size is generally in the range of 0.25 mm to 0.6 mm with less than 1% greater than 2 mm. After the brewing sugars are extracted from the grain, the spent grain is pressed against a filter to reduce moisture below sixty-five percent (65%), and then the grain is dried to further reduce its moisture to less than ten percent (10%). The dried spent grain, after the aforementioned processing, is fed into a combustion chamber for a steam boiler that is used for beer brewing, and the spent grain is advanced downward through the combustion chamber with agitation to aid combustion.
US09447353B2	Pipeline arrangement for utilizing a gas comprising biomethane Embodiments of the invention provide a process in which a gas comprising biomethane having a heating value of less than about 925 BTU/cubic foot is introduced to a pipeline system that is connected to at least one source of natural gas having a heating value of at least about 950 BTU/cubic foot. The gas comprising biomethane combines with natural gas in the pipeline system to produce a mixed gas having a heating value below about 925 BTU/cubic foot. An amount of natural gas at least equal to the amount of gas comprising biomethane is withdrawn from the pipeline system for use as a transportation fuel, a fuel intermediate or as a feedstock for producing a fuel. The process can enable fuel credit generation and/or reductions in life cycle greenhouse gas emissions.
US09447341B2	Process and apparatus for recovering and blending hydroprocessed hydrocarbons and composition A process and apparatus provides for blending a heavy naphtha stream with a diesel stream to increase the yield of diesel. The diesel stream is recovered separately from a kerosene stream to leave the kerosene stream undiminished. The blended diesel provides a valuable composition.
US09447340B2	Hexylene glycol fuel additive containing boric acid for inhibiting phase separation and corrosion in Ethanol Blended Fuels The present invention relates to a fuel additive formulation that is designed to inhibit and/or reverse phase separation in Ethanol Blended Fuels (EBFs). The additive may further have the characteristics of reducing friction, corrosion, and wear in internal combustion engines that run on EBFs. The fuel additive in accordance with the present invention is a formulation of hexylene glycol and boric acid. Minimization of phase separation and reduction of engine wear and degradation due to friction and deposit formation is expected to result in increased engine efficiency, extension of engine life, and reduction in repair and maintenance costs.
US09447338B2	Production of renewable biofuels Renewable fuels are produced in commercial quantities and with enhanced efficiency by integrating a bio-oil production system with a conventional petroleum refinery so that the bio-oil is co-processed with a petroleum-derived stream in the refinery. The techniques used to integrate the bio-oil production system and conventional petroleum refineries are selected based on the quality of the bio-oil and the desired product slate from the refinery.
US09447334B2	Process for converting feeds derived from renewable sources with pre-treatment of feeds by hot dephosphatation The invention concerns a process for the pre-treatment of an unrefined vegetable or animal oil, consisting of passing said oil through a reactor comprising at least one fixed bed of at least one adsorbent comprising a porous refractory oxide which is free of catalytic metals, at a temperature in the range 130° C. to 320° C., at a pressure in the range 0.1 to 7 MPa and with a residence time for said oil on said fixed bed in the range 0.1 to 1 hour. The invention concerns a process for pre-treatment of a semi-refined vegetable or animal oil, integrated upstream of a hydrotreatment step for the production of green gas oil.
US09447333B2	Aviation fuel base oil and aviation fuel composition The present invention provides an environment friendly aviation fuel base oil having combustibility, oxidation stability and excellent life cycle characteristics and contributing to diversification of primary energy, which is produced by hydrotreating a feedstock comprising a mixed oil of an oxygen-containing hydrocarbon compound originating from an animal or vegetable fat and a sulfur-containing hydrocarbon compound or a feedstock comprising said mixed oil and a petroleum base oil produced by refining crude oil and an aviation fuel composition comprising the aviation fuel base oil, and an aviation fuel composition containing such an aviation fuel base oil.
US09447332B2	Conversion of plastics to olefin and aromatic products using temperature control A method of producing olefins and aromatic compounds from a feedstock includes introducing a hydrocarbon feedstock and a catalyst composition that is suitable for converting the feedstock to at least one of olefins and aromatic compounds within a reactor. The reactor has a reactor flow path having a length L between the inlet and outlet. The temperature in the reactor is monitored in at least one location that is at or adjacent to the inlet at a temperature-monitoring distance that is from 0.3 L or less from the inlet. In response to the monitored temperatures one or more parameters are modified. At least a portion of the feedstock is allowed to be converted to at least one of olefins and aromatic compounds within the reactor, which are removed as a product stream.
US09447331B2	Processing combustible material methods and systems Methods, systems and units for liquefaction of combustible material are provided. After separating the combustible material from waste rock gravitationally in an aqueous salt solution selected to have a density which is intermediate between a density of the combustible material and a density of the waste rock and after heating and grinding the separated combustible material to yield a paste of purified combustible material, the paste is fluidizing and hydrogenated underground in a hydrogenation chamber including a Segner turbine. The described processes significantly reduce the energy consumption of the process, remove environmental hazards and result in more efficient liquefaction with respect to existing technologies.
US09447329B2	Analogue ionic liquids for the separation and recovery of hydrocarbons from particulate matter Systems, methods and compositions for the separation and recovery of hydrocarbons from particulate matter are herein disclosed. According to one embodiment, a method includes contacting particulate matter with at least one analogue ionic liquid. The particulate matter contains at least one hydrocarbon and at least one solid particulate. When the particulate matter is contacted with the analogue ionic liquid, the hydrocarbon dissociates from the solid particulate to form a multiphase system.
US09447328B2	Hydropyrolysis of biomass for producing high quality liquid fuels A self-sustaining process for producing liquid fuels from biomass in which the biomass is hydropyrolyzed in a reactor vessel containing molecular hydrogen and a deoxygenating catalyst, producing a partially deoxygenated pyrolysis liquid, which is hydrogenated using a hydroconversion catalyst, producing a substantially fully deoxygenated pyrolysis liquid and a gaseous mixture comprising CO and light hydrocarbon gases (C1-C4). The gaseous mixture is reformed in a steam reformer, producing reformed molecular hydrogen, which is then introduced into the reactor vessel for hydropyrolizing the biomass. The deoxygenated liquid product is further processed to produce diesel fuel and gasoline.
US09447327B2	Asphalt oxidation process using liquid jet ejection Provided is a process for increasing the softening temperature of asphalts by use of liquid jet ejector with a diptube connected to the discharge connection of the liquid jet ejector for ejecting an air/asphalt mixture below a liquid level in an oxidizer vessel. The liquid jet ejector is used as both an air compressor and an air/oil mixer. The liquid jet ejector motive fluid is hot asphalt and the entrained vapor is air. The combined liquid jet ejector with a diptube process provides for an improvement in asphalt air blowing efficiency by requiring less cumulative air to produce a given asphalt softening temperature.
US09447325B1	Pyrolysis oil composition derived from biomass and petroleum feedstock and related systems and methods A pyrolysis oil composition that is soluble in hydrocarbon fuel, and related systems and methods for making the composition, are described. In an exemplary embodiment, a process for making a pyrolysis oil composition involves pyrolyzing biomass to generate biomass-derived pyrolysis vapor therefrom, vaporizing petroleum feedstock to generate petroleum feedstock-derived vapor therefrom, blending the biomass-derived pyrolysis vapor and petroleum feedstock-derived vapor together, condensing the blended biomass-derived pyrolysis vapor and petroleum feedstock-derived vapor simultaneously to form a condensate, and collecting the condensate.
US09447324B2	Hydrocarbon conversion process The invention relates to a process for converting hydrocarbons into unsaturated products such as acetylene and/or ethylene. The invention also relates to converting acetylene to olefins such as ethylene and/or propylene, to polymerizing the olefins, and to equipment useful for these processes.
US09447322B2	Corrosion inhibitor compositions comprising tetrahydrobenzotriazoles solubilized in activating solvents and methods for using same A composition with one or more tetrahydrobenzotriazoles and one or more one or more tetrahydrobenzotriazole activating solvents, wherein the tetrahydrobenzotriazoles are solubilized in the activating solvents in an amount effective to inhibit corrosion of a metal or metal alloy which is corrodible in the presence of copper or copper corroding agents. Also, a method of using this composition to inhibit corrosion of a metal component which has a metal or metal alloy which is corrodible in the presence of copper or copper corroding agents.
US09447321B2	Oxygen scavenging compositions for plastic containers The present invention provides an oxygen scavenging composition for incorporation into a wall of a package. The composition comprises a polyester base polymer, at least one oligomeric, oxidizable poly(alkylene ether) glycol-α,ω-diester having the formula and at least one transition metal in a positive oxidation state. The compositions of the present invention do not exhibit an induction period prior to the onset of oxygen scavenging upon formation into a container.
US09447319B2	Yellow phosphor having an increased activator concentration and a method of making a yellow phosphor A yellow phosphor having an increased activator concentration includes a host lattice comprising yttrium aluminum garnet (YAG) and an activator comprising cerium in the host lattice, where the cerium is present at a concentration of at least about 5 wt. % Ce. A method of making a yellow phosphor includes forming a reaction mixture comprising: a first precursor comprising cerium and oxygen; a second precursor comprising cerium and fluorine; a third precursor comprising yttrium; and a fourth precursor comprising aluminum. The reaction mixture is heated in a reducing environment at a temperature sufficient to form a yellow phosphor including a host lattice comprising yttrium aluminum garnet and an activator comprising cerium (Ce) incorporated in the host lattice.
US09447316B2	Particle aggregate, manufacturing method for particle aggregate, fluorescence enhancing element, and device using photochemical reactions Provided is a hollow particle aggregate formed by aggregating a plurality of self-organizable particles, wherein a metal core is modified by a surface modifier for a metal core comprising a first segment comprising an optionally branched fluorinated alkylene glycol group, an optionally branched fluorinated alkylene group, or an optionally branched fluorinated azaalkylene group; a second segment comprising at least one hydrophilic group and bonding to one of the ends of a main chain of the first segment; and a functional group that bonds directly or indirectly to the another end of the main chain of the first segment and is able to bond to the metal core.
US09447315B2	Electrophilic acid gas-reactive fluid, proppant, and process for enhanced fracturing and recovery of energy producing materials An electrophilic acid gas-reactive fracturing and recovery fluid, proppant, and process are detailed. The fluid expands in volume to provide rapid and controlled increases in pressure that enhances fracturing in subterranean bedrock for recovery of energy-producing materials. Proppants stabilize openings in fractures and fissures following fracturing.
US09447312B2	Dielectric fluids compositions and methods Green compositions and technologies are provided. In an embodiment, the present invention provides a method of providing dielectric fluids, heat transfer fluids or cooling fluids. The dielectric fluid, heat transfer fluid, or cooling fluid can comprise one or more by-product or co-product containing glyceride and fatty acid mixtures extracted from an ethanol process. In an embodiment, the present invention provides compositions of dielectric fluids, heat transfer fluids or cooling fluids. The dielectric fluid, heat transfer fluid, or cooling fluid can comprise one or more glyceride and fatty acid mixtures extracted from an ethanol process.
US09447310B2	Biological buffers with wide buffering ranges Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.
US09447306B2	CMP polishing fluid, method for manufacturing same, method for manufacturing composite particle, and method for polishing base material A CMP polishing liquid comprises water and an abrasive particle, wherein the abrasive particle comprises a composite particle having a core including a first particle, and a second particle provided on the core, the first particle contains silica, the second particle contains cerium hydroxide, and the pH of the CMP polishing liquid is equal to or lower than 9.5.
US09447303B2	Composition for forming resist underlayer film A composition for forming a resist underlayer film includes (A) a compound. The compound (A) includes a group represented by formula (1). R represents a monovalent organic group having 1 to 30 carbon atoms. The monovalent organic group represented by R does not include an oxygen atom at an end of the side adjacent the sulfur atom. * represents a bonding hand. The compound (A) preferably includes a ring which is an aromatic ring, a heteroaromatic ring, or a combination thereof. The bonding hand denoted by * in the group represented by the formula (1) is preferably linked directly or via an oxygen atom to the ring.
US09447301B2	Metal nanowire inks for the formation of transparent conductive films with fused networks Fusing nanowire inks are described that can also comprise a hydrophilic polymer binder, such as a cellulose based binder. The fusing nanowire inks can be deposited onto a substrate surface and dried to drive the fusing process. Transparent conductive films can be formed with desirable properties.
US09447300B2	Ink, ink set, and recording device There is provided an ink comprising a colorant, a polymer particle, water, and a water-soluble organic solvent, wherein the ink has a static surface tension of 30 mN/m or less and, when examined for dynamic surface tension by the maximum bubble pressure method, has a width of variations in dynamic surface tension, for a period from 1 msec after to 1 sec after, of 0.2 mN/m to 3.0 mN/m.
US09447299B2	Inks for 3D printing gradient refractive index (GRIN) optical components Optical inks suitable for 3D printing fabrication of gradient refractive index (GRIN) optical components are composed of a monomer matrix material [100] in which ligand-functionalized nanoparticles [102] are well dispersed at more than 2% loading to induce a change in the index of refraction of the matrix of at least 0.02. The ligands are less than 1.2 nm in length and are covalently bonded to both the nanoparticles and the monomer matrix. The nanoparticles are less than 100 nm in size and the doped matrix material has a transmittance of at least 90% at wavelengths of interest. The matrix material has less than 20 cPoise viscosity and is UV crosslinkable to form a cured polymer.
US09447297B2	Phase change ink containing amorphous amides A phase change ink composition comprising an amorphous amide compound, a crystalline compound; an optional synergist; an optional dispersant; and an optional colorant; wherein the amorphous amide compound is of the formula wherein R is selected from the group consisting of an alkyl group, an aryl group, an alkylaryl group, an arylalkyl group, and combinations thereof, or wherein the amorphous amide compound is of the formula wherein R1 is selected from the group consisting of an alkylene group, an arylene group, an alkylarylene group, an arylalkylene group, and combinations thereof.
US09447294B2	Active energy ray curable composition, and cured product and use thereof Provided is an active energy ray-curable composition that is capable of improving adhesiveness of a cured product and of suppressing detachment or peeling of the cured product as well as a cured product and use thereof. The active energy ray-curable composition contains, as active ingredients, an oxetane alcohol represented by the following structural formula (1) or (2), a silane coupling agent, and a photoacid-generating agent. A silicon component in the silane coupling agent is contained in an amount of preferably 1 to 21% by mass, in terms of silica (SiO2), in the active energy ray-curable composition. In the formula, p is an integer of 1 to 10.
US09447292B2	Wetting and dispersing agent, production method and use thereof The invention relates to a wetting and dispersing agent that can be produced by carrying out step (1): wherein a) an organic polymer containing primary and/or secondary amino groups and b) at least one branched polyhydroxymonocarboxylic acid comprising, in addition to a carboxyl group, at least two hydroxy groups, one of which is not bound to the main chain of the molecule, are reacted by condensation reactions, forming amide linkages; and step (2): wherein at least some of the hydroxy groups of the hydroxy-functional reaction product obtained in step (1) are reacted with at least one organic monoisocyanate, forming urethane linkages.
US09447290B2	Powder paint composition and method for preparing same Disclosed is a powder paint composition of and a method for preparing the same. More particularly, the present invention relates to a powder paint composition including a powder paint prepared by physically attaching metallic particles to a powder resin, which exhibits no separation or aggregation of metallic particles when coated and significantly improves metallic texture owing to orientation of the metallic particles, and a method for preparing the same.
US09447289B2	Method for the establishment of a crack resistant epoxy paint coat and paint compositions suitable for said method The present invention relates to a method for the establishment of a crack resistant epoxy paint coat and paint compositions suitable for said method. The method is developed for use in ballast tanks e.g. a ballast tank of a vessel. The method involves the steps: (i) applying a paint composition comprising an epoxy-based binder system onto the surface thereby forming a curable paint film on the surface, and (ii) allowing the curable paint film to cure thereby forming the epoxy paint coat. The paint composition has a viscosity of at the most 140 KU, when ready to be applied. The paint composition comprises 35-80% by solids volume of the paint of an epoxy-based binder system having a ratio between the hydrogen equivalents and the epoxy equivalents in the range of 20:100 to 120:100. The paint composition furthermore comprises 0.5-30% by solids volume of the paint of one or more fibers. The fibers have an average length, of at the most 250 μm.
US09447288B2	Anti-reflective coating composition providing improved scratch resistance, anti-reflective film using the same, and manufacturing method thereof The present invention relates to an anti-reflective coating composition providing improved scratch resistance, a method for manufacturing an anti-reflective film using the same, and an anti-reflective film manufactured thereby. According to the present invention, provided are a composition that is able to form a coating layer having improved surface scratch resistance, while forming one or more layers by a single coating process, and an anti-reflective film manufactured by using the same.
US09447273B2	Process for the preparation of granules based on expandable thermoplastic polymers and relative product A particulate polymeric composition capable of being processed to provide expanded articles having a density lower than or equal to 50 g/l and a closed cell content of at least 60% as specified by ASTM D-2856, wherein resulting particulates have a shape factor ranging from 0.6 to 0.99; and wherein the particulate polymeric composition is produced according to a process that prepares expandable granules based on thermoplastic polymers, through a granulation die.
US09447272B2	Solar cell sealing material, and solar cell module prepared by using same Provided are a solar cell encapsulant material which facilitates production of solar cell modules, which does not require a crosslinking step and which is excellent in heat resistance and others, and a solar cell module produced by the use of the encapsulant material. The solar cell encapsulant material comprises a resin composition (C) that contains an olefin-based polymer (A) satisfying the following requirement (a) and an olefin-based polymer (B) satisfying the following requirement (b). (a) The crystal melting peak temperature of the polymer, as measured at a heating rate of 10° C./min in differential scanning calorimetry, is lower than 100° C. (b) The extrapolated onset temperature of melting of the polymer, as measured at a heating rate of 10° C./min in differential scanning calorimetry, is 100° C. or higher.
US09447271B2	Zinc ionomer rubber activator Curable rubber compositions and cured articles are based on the use of zinc activator compositions for the sulfur cure. Activator compositions contain zinc and a polymeric component having a plurality of COOH groups, at least some of which are neutralized with the zinc. With polymeric zinc activators, sulfur cure can be activated at levels of zinc below those used in conventional systems.
US09447269B2	Modified flexible EVOH for high performance films The present invention relates to a film having a combination of good flexibility and excellent barrier properties. The film comprises at least one barrier layer. The barrier layer comprises at least 5 percent, by weight of the layer, of an anhydride and/or carboxylic acid functionalized ethylene/alpha-olefin interpolymer having a density in the range of from 0.855 to 0.900 g/cm3; and having a melt index (190° C./2.16 kg) of greater than 200 g/10 min. The barrier layer further comprises at least 60 percent, by weight of the layer, of an interpolymer derived from ethylene and vinyl alcohol monomer units.
US09447267B2	Modified polypropylene composition and laminate using the same It is an object of the present invention to provide a modified polypropylene composition for forming laminates, which enables prevention of lowering of interlaminar bond strength even in the case where it is subjected to high-speed molding or subjected to stretch molding, and a laminate using the composition and having excellent interlaminar bond properties. The present invention relates to a modified polypropylene composition comprising a propylene-based polymer (A-1), 0 to 45% by weight of a propylene-based polymer (A-2), an ethylene/α-olefin copolymer (B) having a melt flow rate (MFR; ASTM D1238, 230° C., load of 2.16 kg) of 0.01 to 40 g/10 min and a density (ASTM D1505) of not more than 0.900 g/cm3, and a specific amount of modified polypropylene (C) a part or all of which has been graft-modified with an unsaturated carboxylic acid or a derivative thereof.
US09447261B2	Cellulose acylate film, polarizing plate and liquid crystal display device To provide a cellulose acylate film having low moisture permeability and low haze, a polarizing plate, and a liquid crystal display device using the same. A cellulose acylate film comprising at least a cellulose acylate, and a compound represented by the formula (1) below: in the formula (1), R1 represents a hydrogen atom or substituent, R2 represents a substituent represented by the formula (2) below; n1 represents an integer of 0 to 4, when n1 is 2 or larger, the plurality of (R1)s may be same with or different from each other; n2 represents an integer of 1 to 5, when n2 is 2 or larger, the plurality of (R2)s may be same with or different from each other.
US09447257B2	Polymers combined with certain additives and devices made thererom This invention relates to polymer compositions comprising: (1) at least one polymer selected from the groups consisting of:nylon, polyesters, copolyesters, polyethylene, polypropylene, polyamides; polystyrene, polystyrene copolymers, styrene acrylonitrile copolymers, acrylonitrile butadiene styrene copolymers, poly(methylmethacrylate), acrylic copolymers, poly(ether-imides); polyphenylene oxides or poly(phenylene oxide)/polystyrene blends, polystyrene resins; polyphenylene sulfides; polyphenylene sulfide/sulfones; poly(ester-carbonates); polycarbonates; polysulfones; polysulfone ethers; and poly(ether-ketones); or mixtures of any of the other foregoing polymers, and (2) at least one fluoroalkyl derivative.
US09447253B2	High temperature shape memory polymers A shape memory composition includes a high temperature ionomer having a glass transition temperature or a melting temperature of 100° C. or greater and a modulus at room temperature of 1×108 Pa or greater, the high temperature ionomer including a polymer with ionic units either within the backbone of the polymer or pendant to the backbone or both. The shape memory composition includes crystalline or glassy domains of a low molecular weight non-polymeric compound dispersed in the high temperature ionomer and interacting the ionic units of the high temperature ionomer to form a secondary network characterized by being a reversible network in that it is compromised by the heating of the low molecular weight non-polymeric compound to change out of its crystalline or glassy phase.
US09447252B2	Polypropylene-based resin composition and method for manufacturing polypropylene composite material The present invention relates to a polypropylene-based resin composition including: (A) a polypropylene resin in an amount of about 40 to 90 wt %, (B) a metal hydroxide in an amount of about 1 to about 25 wt %, (C) an inorganic filler in an amount of about 5 to about 15 wt %, and (D) a polyolefin-based elastomer in an amount of about 0 to about 20 wt %, and a method for manufacturing the polypropylene-based resin composition.Accordingly, the polypropylene-based resin composition may be applied widely to a molded product of interior or exterior parts of a vehicle because a polypropylene resin composition containing a metal hydroxide may be used to manufacture interior and exterior products of a vehicle, thereby achieving weight reduction due to excellent foaming quality during the foaming injection and improved mechanical properties.
US09447250B2	Method for removing residual titanium from a polyester solution The present invention provides a method for reducing level of titanium in an aqueous solution of polyester in a safe and effective way, while avoiding hydrolysis of the polyester.
US09447248B2	Polymeric material for container A formulation for producing a polymeric material including high-density polyethylene, a chemical blowing agent, and other optional components is described.
US09447247B2	Composition and procedure for obtaining a film of micro porous thermoplastic polymer that is especially suited to the production of personal hygiene articles such as diapers and sanitary towels The present invention consists in a method and a composition for obtaining films of a thermoplastic polymer, preferably polyethylene, that are non-breathable and heavily charged with treated mineral particles in order to leave hollow spaces in the structure thereof, resulting in a significant reduction in density.Owing to the fact that said films exhibit improved stability to the stresses they undergo during processing in diaper-production machines, and because, furthermore, they offer an important saving in terms of costs owing to the high mineral-filler content thereof and the low density thereof, they are especially suited to use as an outer covering for disposable diapers and sanitary towels.
US09447246B2	Method of covalently bonding an organic metal complex to a polymer The invention relates to a method for covalently bonding an organic metal complex to a polymeric matrix. The method comprises the performance of a first reaction, which comprises a first reactant in the form of an organic metal complex and a second reactant in the form of a polymer, where during the reaction the metal complex is covalently bound to the polymer. According to the invention, the metal complex catalyzes the reaction.
US09447242B2	Polybenzimidazole solution in an ionic liquid A polybenzimidazole solution comprises a polybenzimidazole dissolved in an ionic liquid excluding 1-butyl-3-methylimidazolium chloride, 1-butyl-3-methylimidazolium hydroxide, and 1-butyl-3-methylimidazolium tetrafluoroborate.
US09447241B2	Polyimide film The present invention provides a polyimide film which is both outstandingly transparent and highly heat resistance, and which can be usefully employed as a transparent electrically conductive film, a TFT substrate, a flexible printed circuit substrate, and the like.
US09447238B2	Polyphenylene oxide resin, method of preparing polyphenylene oxide resin, polyphenylene oxide prepolymer and resin composition A polyphenylene oxide resin belongs to a polymerized and/or modified thermosetting polyphenylene oxide resin, having a structure represented by formula (I): The polymerized and/or modified thermosetting polyphenylene oxide resin has better flame retardancy, thermal resistance, dielectric constant, dissipation factor, toughness, reactivity, viscosity and solubility. Therefore, the polyphenylene oxide resin is suitable for producing prepregs, resin films, laminates, printed circuit boards and other articles. A method of preparing polyphenylene oxide resins, a prepolymer thereof and a resin composition containing the polyphenylene oxide resin are also provided.
US09447235B2	Polycarbonate manufacturing method and polycarbonate The present invention relates to a method of producing polycarbonate containing following step (a) and step (b), (a) a step of reacting a specific fluorine-containing carbonate (Compound (1), etc.) and an aromatic dihydroxy compound in the presence of a condensation catalyst, to obtain a prepolymer, and (b) a step of heating the prepolymer at a temperature which is lower than a melting temperature of the prepolymer and performing solid phase polymerization on the prepolymer while a fluorine-containing alcohol that is produced as a by-product is discharged out of a system, to obtain a polycarbonate.
US09447232B2	Carrier polymer particle, process for producing the same, magnetic particle for specific trapping, and process for producing the same A process for producing carrier polymer particles comprising covering the surface of organic polymer particles having a particle diameter of 0.1 to 20 micrometers with a saccharide by chemically bonding the organic polymers and the saccharide.
US09447231B2	Outer casing and method for producing the same An outer casing for an electric device which is a molded article of a environmental resin wherein poly(lactic acid) and/or a lactic acid copolymer is used, is constituted by molding a flame-retarded resin composition including a resin component containing poly(lactic acid) and/or the lactic acid copolymer as a main ingredient, and silica-magnesia catalyst particles as a flame retardance-imparting component which imparts flame retardance, wherein an organometallic compound is attached to a part of surfaces or the entire surfaces of the silica-magnesia catalyst particles. The organometallic compound is preferably a titanium-based coupling agent or a zirconium-based coupling agent.
US09447230B2	Polyester ethers derived from asymmetrical monomers based upon bisanydrohexitols A process for producing a copolyester through the production of an AB monomer of isoidide - Isodide 2-(4-carbomethoxyphenyl) ether. In certain aspects, the AB monomer is produced by performing the steps of: protecting the 2-position of isosorbide with a protecting group; functionalizing the 5-position of isosorbide with a suitable leaving group to form a reactive ester; nucleophilicly displacing the leaving group in a reaction with an alkali metal alkoxide or phenoxide to give an isoidide ether through a stereochemical inversion of the 5-position; and removing the protective moiety to create the AB monomer. In certain embodiments, the copolyester is produced by melting the AB monomer and a polyester, optionally with a catalyst.
US09447217B2	Method for producing a membrane electrode including forming the membrane in situ A hydrophilic cross-linked polymer obtainable by copolymerisation of hydrophobic and hydrophilic monomers that give a cross-linked hydrophilic polymer on polymerisation; a monomer including a strongly ionic group; and water is useful as the membrane in an assembly that can be used in an electrolyter or fuel cell.More generally, a membrane electrode assembly comprises electrodes and an ion-exchange membrane which comprises a hydrophilic polymer including a strongly ionic group.A method for producing a membrane electrode assembly comprising electrodes and an ion-exchange membrane, comprises introducing between the electrodes a material or materials from which the membrane can be formed, and forming the membrane in situ.
US09447215B2	Multistage emulsion polymer and improved pigment efficiency This invention provides a multistage emulsion polymer including, as copolymerized units: from 0.5% to 5%, by weight P-acid monomer, based on the weight of the emulsion polymer; from 0% to 0.05% by weight multiethylenically unsaturated monomer, based on the weight of the emulsion polymer; and at least one second monoethylenically unsaturated monomer; the emulsion polymer having a calculated Tg of from −20° C. to 50° C.; the emulsion polymer is formed by the “pulsed” addition of 75% to 100% of the P-acid monomer during a stage including from 10% to 50% of the total monomer weight, preferably added during the relatively early stages of the polymerization. A multistage polymer/TiO2 composite particle and an aqueous coating composition including the composite particle are also provided.
US09447210B2	Olefin composition Provided are an olefin composition, filler and an optoelectronic device. One illustrative olefin composition may be effectively used as a filling material for various optoelectronic devices.
US09447209B2	Process for the preparation of diene polymers or of random vinyl arene-diene copolymers Process for the preparation of diene polymers or random vinyl arene-diene copolymers which comprises (co)polymerizing, anionically, in the presence of at least one hydrocarbon solvent, at least one conjugated diene monomer and optionally at least one vinyl arene, in the presence of at least one lithium-based initiator, at least one aprotic polar compound, and at least one compound containing one or more functional groups of the acetylenic type. Said process allows diene polymers or random vinyl arene-diene copolymers to be obtained, which can be advantageously used in the production of tires, in particular in the production of tire treads. The diene polymers or the random vinyl arene-diene copolymers obtained through said process can also be used for the modification of plastic materials [for example, for obtaining high impact polystyrene (HIPS)].
US09447204B2	Methods for terminating olefin polymerizations Catalyst deactivating agents and compositions containing catalyst deactivating agents are disclosed. These catalyst deactivating agents can be used in methods of controlling polymerization reactions, methods of terminating polymerization reactions, methods of operating polymerization reactors, and methods of transitioning between catalyst systems.
US09447202B2	Oligomerisation of olefinic compounds with reduced polymer formation A process for oligomerization of an olefinic compound for producing an oligomeric product is carried out in the presence of an activated catalyst, a non-metal oxygen containing additive and optionally a zinc compound. The oligomerization catalyst is an activated catalyst, which is provided by combining a source of chromium, a ligating compound, and a catalyst activator or combination of catalyst activators. The non-metal oxygen containing additive is present in an amount such that the ratio of the molar amount of the non-metal oxygen containing additive to the molar amount of chromium in the source of chromium per 106 g/g Cr productivity is between 0.01 and 400.
US09447201B2	Polymerization inhibitor composition and method of inhibiting polymerization of distillable monomers The present invention relates to a polymerization inhibitor composition and a method of inhibiting polymerization of distillable monomers in liquid and evaporated/condensed phases with the polymerization inhibitor composition. The polymerization inhibitor composition is useful for inhibiting polymerization of the distillable monomers during manufacture, purification (e.g., distillation), handling, and storage thereof.
US09447199B2	Method for extracting brown algae polysaccharide via microwave chemical process This invention relates to an extraction process of brown algae polysaccharides in a field of pharmaceutical chemistry. This invention particularly discloses a process of extracting brown algae polysaccharides based on a microwave chemistry method and brown algae polysaccharides obtained by said process. The process of the invention comprises: 1) putting pulverized brown algae powder into a microwave reaction chamber, adding acid solution to conduct reaction; optionally concentrating the mixer, and then washing with organic solvent to remove excess acid; conducting grading alcohol precipitation after water extract to obtain mannuronic acid rich fragment (M rich) algin, fucoidan and/or laminaran respectively; and adding an alkali solution to the brown algae residue to conduct alkaline digestion, filtering the residue off, adjusting pH of the filtrate to neutral, conducting alcohol precipitation to obtain guluronic acid rich fragment (G rich) algin precipitates. The present invention has significant advantages like fast processing rate, high yield of polysaccharides, strong controllable polysaccharide degradation, using less organic acid and efficient recovery, small water consumption, low power consumption, etc., the active polysaccharides has high yield and content, better water-soluble, and good biological activities.
US09447194B2	Bispecific chimeric antigen receptors and encoding polynucleotides thereof The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.
US09447193B2	Methods for suppressing cancer by inhibition of TMCC3 A method for treating cancer includes administering to a subject in need thereof an antibody against a transmembrane and coiled-coil domains protein 3 (TMCC3), wherein the antibody binds to an epitope in an extracellular domain of TMCC3. The antibody binds to an epitope in an intercoil domain of TMCC3. A method of diagnosing or assessing a cancer condition includes assessing a level of expression or activity of a transmembrane and coiled-coil domains protein 3 (TMCC3) in a sample, wherein an increase in the level of expression of activity of TMCC3 as compared to a standard indicates the presence of cancer stem cells in the sample.
US09447188B2	Method for controlling the main complex N-glycan structures and the acidic variants and variability in bioprocesses producing recombinant proteins The present invention relates to a method of controlling quality and quantity of posttranslational modification of a recombinantly produced polypeptide/protein (glycoprotein), wherein the posttranslational modification affects the glycosylation profile and/or the acidic variants profile, as manifested in CEX profiles, wherein the polypeptide/protein (glycoprotein) production is in eukaryotic host cells, the method comprising the following steps: a) cultivating the eukaryotic cells in a suitable medium under conditions which allow the expression of the polypeptide/protein, wherein the content of the dissolved CO2 (pCO2) in the medium is at a first value during the initial growth phase of the eukaryotic cells, allowing the eukaryotic cells to grow, and b) increasing or decreasing the content of the dissolved CO2 (pCO2) in the medium during the production phase of the eukaryotic cells to a second value.
US09447186B2	Antibodies to human B7x for treatment of metastatic cancer Methods are provided for treating metastatic cancer in patients having metastatic cancer or for preventing metastasis in cancer patients at risk for metastasis comprising administering to the patient an antibody to B7x, or an active antibody fragment that binds B7x, in an amount effective to treat or prevent metastasis.
US09447185B2	Compositions and methods for treating proliferative disorders The present invention relates to methods of treating proliferative disorders, particularly immunoproliferative and autoimmune disorders, and methods of producing antibodies which bind NK cell receptors for use in therapeutic strategies for treating such disorders, particularly to deplete cells involved in the immunoproliferative pathology.
US09447183B2	IL-1 binding proteins Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.
US09447182B2	Antibodies directed against the alpha chain of IL7 receptor—their use for the preparation of drug candidates The invention concerns antibodies directed against CD127, I.e. the alpha chain of the receptor for interleukin7 (IL-7), especially the receptor for human IL-7 expressed on human cells (designated human IL-7R alpha or IL-7Ra) or the TSLP receptor. The antibodies of the invention have cytotoxic activity against CD127 positive cells. The invention also relates to the use of these antibodies in order to deplete subpopulations of T lymphocytes as a result of cytotoxic action of the antibodies, through ADCC and optionally through CDC. Accordingly the invention concerns the use of the antibodies in the treatment of transplant rejection, autoimmune diseases, allergic diseases, lymphoma or cancer when these pathologies are associated with CD127 positive cells.
US09447181B2	Antibodies against nerve growth factor (NGF) with enhanced in vivo stability The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
US09447179B2	Antibodies to phosphorylated tau aggregates This invention concerns affinity tools for oligomeric forms of tau protein. It relates to the field of neurodegeneration, more particularly to the field of tau-related diseases and tauopathy. The invention provides novel tau antibodies and antibody fragments, nucleic acids encoding such antibodies and antibody fragments, cell lines producing such antibodies and antibody fragments, antibody compositions, and kits for the detection of aggregated tau and for the diagnosis of diseases involving aggregated tau. The invention further provides methods for the detection of aggregated tau, for the diagnosis of diseases involving aggregated tau, and for the identification of compositions interfering with the formation and/or stability of tau aggregates.
US09447176B2	Methods and compositions for treating complement-associated disorders The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and use of the compositions in methods for treating or preventing complement-associated disorders. In some embodiments, the inhibitor is chronically administered to patients. In some embodiments, the inhibitor is administered to a patient in an amount and with a frequency to maintain systemic complement inhibition and prevent breakthrough. In some embodiments, the compositions contain an antibody, or antigen-binding fragment thereof, that binds to a human complement component C5 protein or a fragment of the protein such as C5a or C5b.
US09447174B2	Methods for producing recombinant proteins Methods for producing recombinant cell populations are disclosed. The disclosed methods may be used to produce therapeutic polyclonal proteins.
US09447170B2	Modified Stefin A scaffold proteins The invention provides novel scaffold proteins for the display of peptides such as peptide aptamers. The novel scaffold proteins are modifications of Stefin A or STM (a variant of Stefin A) and are useful as scaffold proteins and as display systems.
US09447168B2	Nucleic acid molecules encoding modified factor VIII proteins There is provided a nucleic acid molecule comprising a nucleotide sequence encoding for a functional factor VIII protein, wherein the portion of the nucleotide sequence encoding for the B domain of the factor VIII protein is between 90 and 111 nucleotides in length and encodes for an amino acid sequence comprising a sequence having at least 85% identity to SEQ ID NO: 4 and which comprises six asparagine residues. Also provided is a functional factor VIII protein, a vector comprising the above nucleic acid molecule, a host cell, a transgenic animal, a method of treating hemophilia, e.g. hemophilia A, and a method for the preparation of a parvoviral gene delivery vector.
US09447164B2	Engineered nucleic acids and methods of use thereof Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
US09447159B2	Immunoconjugates The present invention generally relates to antigen-specific immunoconjugates for selectively delivering effector moieties that influence cellular activity. More specifically, the invention provides novel immunoconjugates comprising a first antigen binding moiety, an Fc domain and a single effector moiety. In addition, the present invention relates to polynucleotides encoding such immunoconjugates, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the immunoconjugates of the invention, and to methods of using these immunoconjugates in the treatment of disease.
US09447158B2	Kinase inhibitors and uses thereof The present invention relates to kinase inhibiting compositions and uses thereof. The invention further provides isolated kinase inhibiting peptides and uses thereof for inhibiting hyperplasia, for inhibiting the growth of neoplasms, and for inducing programmed cell death in a cell population.
US09447154B2	Nucleic acids encoding a house dust mite allergen, Der p III, and uses thereof Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.
US09447151B2	Beta sheet tapes ribbons in tissue engineering There is described a material comprising tapes, ribbons, fibrils or fibers characterized in that each of the ribbons, fibrils or fibers have an antiparallel arrangement of peptides in a β-sheet tape-like substructure wherein the material comprises a pair of self assembling complementary polypeptides.
US09447149B2	Methods and compositions for the rapid synthesis of radiometal-labeled probes The present application is directed to rapid and efficient synthesis of radiometal-labeled probes, pharmaceutical compositions comprising radiometal-labeled probes, and methods of using the radiometal-labeled probes. Such radiometal-labeled probes can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT), and therapy studies.
US09447147B2	Peptides and methods of use The invention provides peptides, including peptides that bind and, optionally, inhibit Protein S, and compositions thereof. The peptides may be used to, e.g., inhibit Protein S activity, enhance thrombin formation in a subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify Protein S, and identify a Protein S binding compound.
US09447144B2	MHC class II restricted T cell epitopes from the cancer antigen, NY ESO-1 The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class II epitopes from NY-EsO-1 are recognized by CD4+ T lymphocytes in an HLA class II restricted manner, in particular HLA-DR or HLA-DP restricted. The products of the gene are promising candidates for immunotherapeutic strategies for the prevention, treatment and diagnosis of patients with cancer.
US09447143B2	Peptide fragments for inducing synthesis of extracellular matrix proteins Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.
US09447141B2	Process for the preparation of sterol derivatives The present invention relates to a process for the preparation of sterol derivatives comprising the reaction of an α-epoxy compound with an amine in an alcohol comprising 3 to 5 carbon atoms as a solvent.
US09447140B2	Cholest-4-en-3-one oxime derivatives, pharmaceutical compositions containing same, and preparation method The present invention relates to novel chemical compounds, in particular cholest-4-en-3-one oxime derivatives and to the use thereof as medicaments, especially as cytoprotective medicaments, in particular neuroprotective, cardioprotective and/or hepatoprotective medicaments.
US09447139B2	Ship inhibitors and uses thereof The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.
US09447137B2	Substituted gemcitabine aryl amide analogs In one aspect, the invention relates to substituted gemcitabine aryl amide analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating viral disorders and disorders of uncontrolled cellular proliferation using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
US09447134B2	Compounds and methods for treating mammalian gastrointestinal microbial infections Disclosed are compounds and pharmaceutically acceptable salts thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound selectively inhibits a parasitic IMPDH versus a host IMPDH. Also disclosed are pharmaceutical compositions comprising one or more compounds of the invention. Related methods of treating various parasitic and bacterial infections in mammals are disclosed. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
US09447132B2	Highly active nucleoside derivative for the treatment of HCV A deuterated nucleoside analog of the formula and the pharmaceutically acceptable salts thereof are provided by this disclosure. The disclosure also includes pharmaceutical compositions comprising a compound or salt of the formula and a carrier. Compounds and salts of this formula are useful for treating viral infections, including HCV infections. A method for treating a host afflicted with hepatitis C or other disorders is also presented that includes administering an effective treatment amount of a nucleoside or nucleotide that has deuterium with at least 50% enrichment at the 5′-position of the nucleoside or nucleotide.
US09447131B2	Lignosulfonate of a certain quality and method of preparation of lignosulfonate of a certain quality There is provided a process for improving the quality of lignosulfonate at least partly derived form a spent sulfite cooking liquor in at least two steps, comprising: one step in which a lignosulfonate-containing fraction at least partly derived from the spent sulfite cooking liquor is subjected to filtration using a membrane having a cut-off of 40-150 kD (high cut-off) at the pressure, flow rate and temperature of the step and the permeate is recovered; and another step in which a lignosulfonate-containing fraction at least partly derived from the spent sulfite cooking liquor is subjected to filtration using a membrane having a cut-off of 1-20 kD (low cut-off) at the pressure, flow rate and temperature of the step and the retentate is recovered. Products, uses thereof as well as a system are also provided.
US09447130B1	Process for the preparation of dicycloplatin The present invention relates to a process to prepare dicycloplatin under mild reactive conditions and at fast reaction rates. The process is reproducible and easy to scale up for industrial application.
US09447129B2	Suprametallogels and uses thereof The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers Y. The provided supramolecular complexes are able to form gels (e.g., hydrogels). The gels are suprametallogels and exhibited excellent mechanical properties without sacrificing self-healing and showed high robustness and storage modulus. The present disclosure further provides compositions (e.g., gels) that include the nanostructures or supramolecular complexes and optionally an agent (e.g., small molecule), where the nanostructures and the nanostructure moieties of the supramolecular complexes may encapsulate and slowly release the agent. The nanostructures, supramolecular complex, and compositions may be useful in delivering an agent to a subject, tissue, or cell, as super-absorbent materials, and in treating a disease (e.g., a genetic diseases, proliferative disease (e.g., cancer or benign neoplasm), hematological disease, neurological disease, gastrointestinal disease (e.g., liver disease), spleen disease, respiratory disease (e.g., lung disease), painful condition, genitourinary disease, musculoskeletal condition, infectious disease, inflammatory disease, autoimmune disease, psychiatric disorder, or metabolic disorder).
US09447128B2	Method for preparing trishydroxymethyl phosphine A method for preparing trishydroxymethyl phosphine from tetrakishydroxymethyl phosphonium salt, the method including at least the steps of continuously feeding a first reaction chamber with, from one hand, at least one tetrakishydroxymethyl phosphonium salt and, from another hand, at least one base, under conditions suitable for a reaction of the tetrakishydroxymethyl phosphonium salt(s) with the base(s), to form a mixture of trishydroxymethyl phosphine and formaldehyde; and continuously removing the formaldehyde.
US09447127B2	Synthetic lung surfactant and use thereof The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all three of these materials. Novel phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active peptides are also disclosed herein. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue, to prepare synthetic peptides for use in the surfactant compositions, and to deliver therapeutic agents are also disclosed.
US09447124B2	Multi-thiol mercaptoalkoxysilane compositions The present invention provides multi-thiol mercaptoalkoxysilane compositions and methods of making multi-thiol mercaptoalkoxysilane compositions having the formula: wherein the R3 group, and the R4 group are independently an alkoxy, a halogen, an alkyl, an aryl, a heteroaryl, a heterocycle or derivatives thereof and n is an integer between 1 and 30.
US09447123B2	Process for preparing 2-hydroxyphenyl alkenyl benzotriazole compounds; use of the said compounds obtained via the process in the synthesis of siloxane compounds containing a 2-hydroxyphenylbenzotriazole function The process for preparing 2-hydroxyphenyl alkenyl benzotriazole compounds and the process for preparing siloxane compounds containing 2-hydroxyphenyl benzotriazole function are disclosed.
US09447122B2	Arginase inhibitors and methods of use thereof The present invention includes arginase enzyme inhibitors, compositions comprising these arginase inhibitors, and methods of treating or diagnosing conditions characterized either by abnormally high arginase activity or abnormally low nitric oxide levels in a mammal, comprising administering compositions of the invention to the mammal.
US09447121B2	Triazine based radiopharmaceuticals and radioimaging agents Compounds according to Formula I and Formula II are potent inhibitors of PSMA. Pharmaceutical compositions may include a complex of a radionuclide and a Formula I compound or a Formula II compound. Methods include using the radionuclide complex of a Formula I compound or a Formula II compound for treating or diagnosis of a disease or a condition associated with PSMA activity.
US09447118B2	Preparation method of optically active diamine compound The problem to be solved is to provide a method for efficiently producing compounds (1) and (1a) that are important intermediate compounds in the production of FXa inhibitors (X) and (X-a). The solutions thereto are a method for producing a compound represented by the formula (8d) using a stereoselective intramolecular cyclization reaction, and a method for producing a compound (1f) or a salt thereof, or a hydrate thereof, which is characterized by desulfonylation of the compound (8d). In each formula, R4a represents a C1-C6 alkyl group, a benzyl group, etc.
US09447111B2	Organic thin film transistor, organic semiconductor thin film, and organic semiconductor material An organic thin film transistor containing a compound represented by the formula (1) in a semiconductor active layer has a high carrier mobility and a small fluctuation of the threshold voltage after repeated driving. R1 to R12 represent a hydrogen atom or a substituent, provided that at least one of R1 to R12 represents a substituent represented by the formula (W), or all of R1 to R12 represent a hydrogen atom. * represents a position bonded to the naphthobisbenzofuran skeleton. L represents a single bond, a divalent linking group, an oligoethyleneoxy group having a repeating number of an ethyleneoxy unit of 2 or more, or an oligosiloxane group having 2 or more silicon atoms.
US09447104B2	Method of treatment using substituted pyrazolo[1,5-a]pyrimidine compounds Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
US09447103B2	Inauhzin analogues that induce P53, inhibit cell growth, and have antitumor activity Inauhzin (INZ) was identified as a novel p53 activator, which selectively and efficiently suppressing tumor growth without displaying genotoxicity and with little toxicity to normal cells. A panel of INZ analogs were synthesized and evaluated their ability to induce cellular p53 and to inhibit cell growth in cell-based assays. As described, this leads to the discovery of INZ analog 37, a molecule that exhibits much better potency than INZ in both of p53 activation and cell growth inhibition in several human cancer cell lines including H460 and HCT116+/+ cells. This INZ analog exhibited a much lower effect on p53-null H1299 cells and importantly no toxicity towards normal human p53-containing WI-38 cells. Those results also reveal key chemical features for INZ activity, and identify the newly synthesized INZ analog 37 as a better small molecule for further development of anti-cancer therapies.
US09447100B2	Substituted pyrazolo[1,5-A] pyrimidines as calcium receptor modulating agents There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7-membered ring; ring B is an optionally substituted 5- to 7-membered heterocyclic ring; X1 is CR1, CR1R2, N or NR13; X2 is N or NR3; Y is C, CR4 or N, Z is CR5, CR5R6, N or NR7; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and is a single bond or a double bond; R1, R2, R3, R4, R5, R6, R7 and R13 are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7-membered ring; Q is C, CR5 or N; R8, R9, R10, R11 and R12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided. Also specify X1, R3, R1, Y and X3 in formula (II) and (III) as before.
US09447099B2	Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine The present invention provides methods for preparing 5-[2-[7-(trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]ethynyl]-2-pyridinamine (compound A), which is useful for the treatment of depression and other CNS disorders. The present methods are useful for preparing compound A on large scale in manufacturing facilities.
US09447096B2	Polymorph forms The present invention relates to novel crystal forms of 2-amino-N-[2-(3a-(R)-benzyl-2-methyl-3-oxo-2,3,3a,4,6,7-hexahydro-pyrazolo[4,3-c]pyridin-5-yl)-1-(R)-benzyloxymethyl-2-oxo-ethyl]-isobutyramide L-tartrate. More particularly, the invention relates to polymorph forms, and to processes for the preparation of compositions containing and to uses of such polymorph forms.
US09447093B2	3,5-diarylazaindoles as DYRK1A protein inhibitors for the treatment of cognitive deficiencies associated with Down's syndrome and with Alzheimer's disease The present invention discloses compositions of novel DYRK1A protein inhibitors based on a 3,5-diarylazaindole motif and their preparation and use as medications in the treatment of cognitive disorders associated with dysfunction of DYRK1A protein, with Down's syndrome and with Alzheimer's disease.
US09447090B2	Imidazopyridine compounds An excellent drug for treating or preventing cardiovascular diseases, based on cGMP production enhancing action due to soluble guanylate cyclase activating action, is provided. It was found that imidazopyridine compounds having a carbamoyl group at the 3-position and a substituent bonded at the 8-position via an oxygen atom in an imidazo[1,2-a]pyridine skeleton exhibits a cGMP production enhancing action by a potent soluble guanylate cyclase activating action, and is useful as a drug for treating or preventing various soluble guanylate cyclase-related cardiovascular diseases, thereby completing the present invention.
US09447087B2	Galactokinase inhibitors for the treatment and prevention of associated diseases and disorders Disclosed are inhibitors of human galactokinase of formula (1) that are useful in treating or preventing a galactokinase mediated disease or disorder, e.g., galactosemia. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal. Formula (I).
US09447081B2	Substituted pyrimidines as pharmaceuticals and insecticides The invention discloses a homopiperony lamine compound which has a structural general formula I as follows as shown in the specification: wherein definitions of substituents in the formula are as shown in the specification. The compound shown as the general formula I has broad-spectrum bactericidal and insecticidal activity in the field of agriculture. The compound shown as the general formula I has a good prevention effect on various germs such as cucumber downy mildew, wheat powdery mildew, puccinia sorghi, rice blast and cucumber gray mold, and particularly, still has the good prevention and control effect on the cucumber downy mildew, the puccinia sorghi and the wheat powdery mildew at a lower dosage. At the same time, a part of compound has better insecticidal activity, and can be used for preventing and controlling various insect pests such as diamondback moths, myzus persicae, armyworms and tetranychus cinabarinus boisdu.
US09447079B2	PRMT1 inhibitors and uses thereof Described herein are compounds of Formula (I-a) and (I-b), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT1 activity. Methods of using the compounds for treating PRMT1-mediated disorders are also described.
US09447075B2	Pyridazine derivatives as EAAT2 activators Pyridazine derivatives that activate the excitatory amino acid transporter 2 (EAAT2), and methods use thereof for treating or preventing diseases, disorders, and conditions associated with glutamate excitotoxicity.
US09447074B2	Compounds A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory diseases and/or allergic conditions, in cancer therapy, specifically heme malignancies, and autoimmune conditions.
US09447073B2	Fungicidal compositions The instant invention describes tetrazole compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
US09447070B2	5-substituted isoindoline compounds This invention relates to 5-substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
US09447067B2	Method of preparing intermediate of salmeterol A method of preparing an intermediate of salmeterol (Compound 1, 2-amino-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol) includes: reacting compound 2 with 2-methoxypropene in a first organic solvent to produce a reaction solution including compound 3, compound 2 including a 2-bromo precursor of Compound 1; reacting compound 3 with a nitrogen source to produce compound 4; reacting compound 4 with sodium borohydride in a second organic solvent to produce compound 5; and debenzylating compound 5 by ammonium formate/palladium-carbon catalytic transfer hydrogenation in a third organic solvent to produce Compound 1. A method of preparing salmeterol includes preparing Compound 1, and reacting Compound 1 to prepare salmeterol.
US09447065B2	Pharmaceutical composition The present invention provides a pharmaceutical composition which prevents from decreasing the blood exposure of the third generation coxib-drugs, a process for preparing the said pharmaceutical composition and its use.It has been founded in this invention that adding a basic amine or a basic amino acid, or a cyclodextrin to the third generation coxib-drug can afford a pharmaceutical composition which can prevent from decreasing the blood exposure, AUC and bioavailability. The pharmaceutical composition of the present invention has also good stability, which is useful for drugs. Namely, the technological thought that adding a basic amine or a basic amino acid, or a cyclodextrin to the third generation coxib-drug can prevent from decreasing the blood exposure, AUC and bioavailability has been established in this invention.
US09447064B2	Heterocyclic compound preparing Disclosed is a process for selectively producing (D+1)-member heterocyclic compounds from corresponding unactivated dienes or derivatives thereof in the presence of a transition metal or lanthanide catalyst or a precursor thereof, relative to D-member heterocyclic rings.
US09447063B2	Disubstituted adamantyl derivative or pharmaceutically acceptable salt thereof, production method for same, and pharmaceutical composition for suppressing cancer metastasis comprising same as active ingredient The present invention relates to a novel disubstituted adamantyl derivative or the pharmaceutically acceptable salts thereof, a method for preparing the same, and a pharmaceutical anticancer or antimetastasis composition comprising the same as an active ingredient. The disubstituted adamantyl derivative of the present invention suppressed accumulation of HIF-1α, inhibiting the expression of the metastasis related protein Twist dose-dependently. Thus, the disubstituted adamantyl derivative of the invention is effective in inhibiting the expressions of the metastasis related proteins, β-catenin and RohA, and the EMT related genes such as MMP2 and MMP9, without cytotoxicity. Therefore, the disubstituted adamantyl derivative or the pharmaceutically acceptable salts thereof of the invention can be efficiently used as a pharmaceutical anticancer or antimetastasis composition.
US09447062B2	Manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a production of the Colabomycin E A manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a production of the Colabomycin E. Colabomycin E is a new member of the manumycin-type metabolites produced by the strain Streptomyces aureus SOK1/5-04 deposited in The Czech collection of microorganisms under number CCM8556. The structure of 5 is similar to that of the already known metabolite colabomycin A (3) isolated from Streptomyces griseoflavus. However, the upper polyene chain of 5 is two carbons longer. Therefore, it was named Colabomycin E. Biological activity assays indicated that colabomycin E significantly inhibited IL-1β release from THP-1 cells and might thus potentially act as an anti-inflammatory agent.
US09447059B2	Intermediate for manufacture of polymerizable compound and process for manufacture thereof The present invention pertains to a compound represented by a formula (I) and a method for producing thereof (in the formula, Ax is an organic group having 2 to 30 carbon atoms that includes at least one aromatic ring selected from a group consisting of an aromatic hydrocarbon ring and an aromatic hetero ring, Ay is a hydrogen atom, an alkyl group having 1 to 18 carbon atoms, a cycloalkyl group, an alkenyl group having 2 to 18 carbon atoms, an organic group having 2 to 30 carbon atoms that includes at least one aromatic ring selected from a group consisting of an aromatic hydrocarbon ring and an aromatic hetero ring, or the like. Ax and Ay optionally bond to each other to form a ring, and Q is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or the like.). According to the invention, provided are a novel compound that makes it possible to produce an optical film that achieves uniform conversion of polarized light over a wide wavelength band can be inexpensively produced in high yield by utilizing the compound according to one aspect of the invention as an intermediate for producing the polymerizable compound, and a method for producing thereof.
US09447057B2	Schiff bases of thiazoles: a new class of ureases inhibitors One embodiment of the invention relates to treating diseases associated with increased urease enzyme activity comprising administering an effective amount of a compound selected from a group consisting of 28 thiazoles Schiff bases. Kinetic studies were performed on ten (10) of the most active compounds.
US09447054B2	Anticancer supplement agent including benzo[D]oxazol derivative as effective ingredient Disclosed is an anticancer supplement agent including a benzo[d]oxazole derivative as an effective ingredient. The benzo[d]oxazole derivative, which is a nuclear factor E2-related factor 2 (Nrf2) inhibitor, is capable of inhibiting activity of Nrf2 that induces an antioxidant enzyme to remove reactive oxygen species (ROS) that kills a cancer cell, thereby increasing production of ROS. Therefore, the benzo[d]oxazole derivative can be used as an anticancer supplement agent that shows therapeutic effects in anticancer agent therapy or radiation therapy, and in this regard, the benzo[d]oxazole derivative can overcome tolerance of the cancer cell to anticancer agent therapy or radiation therapy and enhance apoptotic effects on the cancer cell.
US09447052B2	Processes for preparing pyrimidine compounds This invention relates to methods of making a compound of formula (I) and intermediates for same the compounds of formula (I) being useful for treating cardiovascular and inflammatory diseases such as atherosclerosis.
US09447051B2	Diaminopyrimidines and uses thereof This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
US09447050B2	Solid forms of curcumin The present invention provides forms of curcumin and the pharmaceutical compositions thereof. The forms of curcumin disclosed herein are curcumin polymorph Form III, curcumin-2-aminobenzimidazole co-crystal, and curcumin-L-lysine co-crystal. Further, the invention provides methods inhibiting cancer cells and HSV-1 using these curcumin novel solid forms.
US09447048B2	Processes for the preparation of pesticidal compounds The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
US09447041B2	Processes for the preparation of (R)-2-(7-4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof The present invention relates to processes and intermediates useful in the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid of Formula (I) and salts thereof, an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development and atherosclerosis).
US09447034B2	Industrial methods for producing arylsulfur pentafluorides Industrial methods for producing arylsulfur pentafluorides are disclosed. Methods include reacting arylsulfur halotetrafluoride with hydrogen fluoride in the absence or presence of one or more additives selected from a group of fluoride salts, non-fluoride salts, and unsaturated organic compounds to form arylsulfur pentafluorides.
US09447027B2	Treating long QT syndrome This document relates to compounds useful for treating cardiac arrhythmias, for example, long QT syndrome. Also provided herein are methods and materials for using such compounds to shorten myocardial repolarization time in a patient.
US09447021B2	Process for the purification of aniline from gas phase hydrogenations The present invention relates to a process for the purification of aniline which originates from gas phase hydrogenations. In this process, only a minimum proportion of the aniline has to be evaporated and condensed again. The process is highly efficient in removing compounds which have phenolic hydroxyl groups and results in minimal losses of aniline. This process also reduces the unwanted coupling mechanisms in the division of the overall crude product in the fraction condensation into individual substreams and the subsequent workup of these.
US09447020B2	Polyunsaturated fatty acid monoglycerides, derivatives, and uses thereof There are provided compounds of formula (I): wherein X1 is O, NH, or S; X2 is O, NH, or S; and X3 is O, NH, or S; and wherein R, R1, T1 and T2 can represent various entities. Such compounds can be useful, for example, for preventing, palliating or treating various diseases such as heart diseases, respiratory diseases, treating inflammatory abnormalities, metabolic disorders or diabetes.
US09447018B2	Ethyl acetate production A method of purifying an ethyl acetate stream comprises contacting an inlet stream with a solvent, transferring at least a portion of the impurity compound from the inlet stream into the solvent to form an extract and a purified product, separating the extract from the purified product, separating the portion of the impurity compound from the extract, forming an impurities stream and a regenerated solvent, and recycling at least a portion of the regenerated solvent to contact the inlet stream. The inlet stream comprises ethyl acetate and an impurity compound, and the extract comprises the solvent and the portion of the impurity compound transferred from the inlet stream.
US09447015B1	(S)-2′-vinyl-abscisic acid derivatives The invention relates to a novel class of (S)-2′-vinyl-substituted-abscisic acid derivatives, and to methods of synthesizing and using the derivatives.
US09447014B2	Tromethamine salt of bimatoprost acid in crystalline form, methods for preparation, and methods for use thereof The present invention provides tromethamine salt of 7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline and amorphous form. This compound is may also be referred to as “tromethamine salt of bimatoprost acid.” The invention crystalline form is useful for solid ocular implant or topical formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension.
US09447008B2	Acetone production using silicon nanoparticles and catalyst compositions Embodiments of the present disclosure provide for a catalytic reaction to produce acetone, a catalyst that include a mixture of silicon particles (e.g., about 1 to 20 nm in diameter) and a solvent, and the like.
US09447004B2	Methods for removing halogenated ethylene impurities in 2,3,3,3-tetrafluoropropene product The present process relates to a process comprising: contacting a mixture comprising 2,3,3,3-tetrafluoropropene and at least one halogenated ethylene impurity with at least one adsorbent or at least one chemisorption catalyst to reduce the concentration of said at least one halogenated ethylene impurity.
US09447003B2	Method for synthesising trifluoroethylene from chlorotrifluoroethylene The present invention relates to the preparation of trifluoroethylene (VF3 or TrFE) by hydrogenolyzis of chlorotrifluoroethylene (CTFE) in the gaseous phase over a group VIII metal catalyst deposited on a support. This method can be used to obtain VF3 in an economical manner in conditions which minimize the risk of explosion of this molecule. Using a catalyst containing a group VIII metal and, more specifically, containing Pd deposited on a support and a specific series of steps of separation and purification makes it possible to obtain excellent CTFE conversion rates and high selectivity in VF3 at atmospheric pressure and at low temperatures.
US09447002B2	7-acetyleno quinone methide derivatives and their application as vinylic polymerization retarders A method for retarding polymerization of vinyl monomers comprising adding a quinone methide to a liquid comprising the vinyl monomers is described.
US09446992B2	Compounds and methods for improving plant performance The invention is directed to methods and compositions for increasing a growth characteristic of a plant, increasing nutrient use efficiency of a plant, or improving a plant's ability to overcome stress comprising applying a composition comprising ketosuccinamate, a derivative thereof, or a salt thereof, to the plant or to a propagation material of the plant.
US09446990B2	Ceramic inkjet ink for relief effect Disclosed are compositions, such as inkjet inks or glazes, for jetting onto a ceramic substrate, and associated methods and systems. The compositions are configured to produce a blister relief effect, wherein the incorporation of inkjet technology provides precise control over the location and degree of blistering. The enhanced compositions are configured to form gas bubbles when exposed to the elevated temperatures of a firing cycle, wherein the formed gas is trapped within the glaze, causing an expansion or blistering of the glaze, which results in a raised relief.
US09446988B2	Method of producing building materials from recycled items Various building materials constructed from different recycled components are provided. Such materials include boards, bricks, and the like, and exhibit differing levels of tensile strength, heat resistance, and other physical and chemical properties. The capability of introducing varied collected items, including paper, paperboard, clothing fibers, wood chips and strips, raffia bags, used engine oil, etc., and produce a resilient and dimensionally stable building material is presented herein. Replacement of timber and concrete is permitted with such a new material based upon renewable resources. The method of production and use of such materials is encompassed herein as well.
US09446973B2	Processing and application of a purification system for gold mining, extraction of minerals and growth of algae biomass The present disclosure describes a process for using saline water, and saline reject water produced in water purification, to use for gold mining production, and growing and harvesting algae. The disclosure also describes a method for growing and harvesting algae utilizing saline water as growth medium for recycling waste water to extract the remaining metals out of waste water. The harvested algae may be used in various applications including but not limited to water purification for gold mining production and to extract metals out of remaining waste water.
US09446971B2	Techniques for promoting current efficiency in electrochemical separation systems and methods An electrochemical separation system may be modular and may include at least a first modular unit and a second modular unit. Each modular unit may include a cell stack and a frame. The frame may include a manifold system. A flow distribution system in the frame may enhance current efficiency. Spacers positioned between modular units may also enhance current efficiency of the system.
US09446970B2	Membrane module unit and assembly method, disassembly method, and maintenance method for same, and water-treatment apparatus Disclosed is a membrane module unit in which a plurality of membrane modules is coupled together in parallel by coupling means, the membrane module including a sheet-like filter membrane and holding frame members that hold the filter membrane at two opposed sides of a peripheral edge of the filter membrane, wherein the coupling means clamps the holding frame members at the same sides of the filter membranes together by two opposed clamping members. According to the invention, provided is a membrane module unit in which structure is simple, assembly, disassembly, and maintenance can be easily performed, and a plurality of membrane modules can be reliably coupled together. Provided are also an assembly method, disassembly method, and maintenance method of the same, and a water-treatment apparatus.
US09446969B1	Solar driven water purification and transportation system A system and method of water purification and transport driven by solar energy. The system includes an absorbent tank containing an adsorbent. The adsorbent absorbs water vapor from raw water at night. A heat exchanger cools the adsorbent. During the day, solar energy is focused at a cylindrical or oval shaped vessel of the adsorbent tank. As the temperature of the adsorbent increases, its capacity decreases, causing it to release purified water. The purified water is transferred to a storage tank. A transmission pipe containing adsorbent granules or capillaries transports the purified water into a product tank.
US09446968B2	Method and apparatus for programably treating water in a water cooler An apparatus for a programmable self sanitizing water dispenser apparatus with a digital controller as well as a programmable method for generating ozone for cleaning the reservoir and the water contained within it. The apparatus includes an anti-spill receiver that houses the controller and that can contain a ozone generator.
US09446965B2	Applications for inorganic fullerene-like particles A nanostructure that includes a multi-layered fullerene-like nano-structure composed of a plurality of layers each having a metal chalcogenide composition that has a molecular formula of MX2, in which M is a metallic element selected from the group consisting of titanium (Ti), vanadium (V), chromium (Cr), manganese (Mn), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), zirconium (Zr), niobium (Nb), molybdenum (Mo), technetium (Tc), ruthenium (Ru), rhodium (Rh), palladium (Pd), silver (Ag), cadmium (Cd), hafnium (Hf), tantalum (Ta), tungsten (W), rhenium (Re), osmium (Os), iridium (Ir), platinum (Pt), gold (Au), mercury (Hg) and combinations thereof, and X is a chalcogen element selected from the group consisting of sulfur (S), selenium (Se), tellurium (Te), oxygen (O) and combinations thereof. An outer layer of the multi-layered fullerene-like structure includes at least one sectioned portion that extends along a direction away from the curvature of the multi-layered fullerene-like nano-structure.
US09446963B2	System and methods for a cathode active material for a lithium ion battery cell A material includes a first lithium metal oxide (LMO) component formed using a spray-dry technique and a second LMO component formed using a co-precipitation technique. In particular, the LMO components may include lithium nickel manganese cobalt oxide (NMC). The material may further include a binder and a conductive component.
US09446957B2	Polycrystalline silicon rod and method for producing polysilicon Polycrystalline silicon rods produced by the Siemens process produce a higher yield of CZ crystals when the process parameters are modified in a second stage of deposition such that an outer layer of larger crystallites having a mean swize >20 μm is produced. Harvesting of these polycrystalline rods and conventional rods by enclosing them in a plastic bag or sheath prior to removal from the reactor also surprisingly increase the yield of CZ crystals grown from a melt containing the sheathed rods.
US09446953B2	Fabrication of metallic hollow nanoparticles Metal and semiconductor nanoshells, particularly transition metal nanoshells, are fabricated using dendrimer molecules. Metallic colloids, metallic ions or semiconductors are attached to amine groups on the dendrimer surface in stabilized solution for the surface seeding method and the surface seedless method, respectively. Subsequently, the process is repeated with additional metallic ions or semiconductor, a stabilizer, and NaBH4 to increase the wall thickness of the metallic or semiconductor lining on the dendrimer surface. Metallic or semiconductor ions are automatically reduced on the metallic or semiconductor nanoparticles causing the formation of hollow metallic or semiconductor nanoparticles. The void size of the formed hollow nanoparticles depends on the dendrimer generation. The thickness of the metallic or semiconductor thin film around the dendrimer depends on the repetition times and the size of initial metallic or semiconductor seeds.
US09446951B2	Highly-ordered nanostructure arrays and methods of preparation thereof Highly-ordered nanostructure arrays and methods of preparation of the highly-ordered nanostructure arrays for adsorption of pollutants are disclosed. The highly-ordered nanostructure arrays can be vertically aligned metal oxide nanotube arrays having metal-deposited carbon nanotubes within the nanostructures. The metal-deposited carbon nanotubes within the nanostructures increase the adsorption of the pollutants, as discussed in greater detail below. The highly-ordered nanostructure arrays can be included in various filters, such as cigarette filters, to adsorb carcinogens and pollutants from the tobacco smoke.
US09446945B2	Isolation structure for MEMS 3D IC integration A three-dimensional (3D) integrated circuit (IC) includes a first IC and a second IC. The first IC includes a MEMS device and a first bonding structure. The second IC includes a second bonding structure. The first and second bonding structures are bonded together to couple the first IC to the second IC. A conformal barrier layer is disposed over a surface of the second IC nearest the first IC. An etch isolation structure is arranged beneath the surface of the second IC and encloses a sacrificial region which is arranged on either side of the second bonding structure and which is arranged in the second IC.
US09446944B2	Sensor apparatus and method for producing a sensor apparatus In various embodiments, a sensor apparatus is provided. The sensor apparatus includes a sensor device having a plurality of electrical contacts; a housing having a plurality of sidewalls; and a metal carrier structure, which extends into the housing in a manner passing through two mutually opposite sidewalls from the plurality of sidewalls. The metal carrier structure is embodied in a resilient fashion at least in the direction of a sidewall through which the metal carrier structure extends. The sensor device having the plurality of electrical contacts is mounted in a resilient fashion on the metal carrier structure and is electrically conductively connected to the metal carrier structure by the plurality of contacts.
US09446943B2	Wafer-level packaging of integrated devices, and manufacturing method thereof A wafer-level packaging, comprising: a first semiconductor body integrating a MEMS structure; a second semiconductor body, including a surface electrical-contact region and an ASIC coupled to the MEMS structure and to said electrical-contact region; a first coating layer, made of resin, which englobes and protects the first body, the second body, and the electrical-contact region; at least one first conductive through via, which extends through the first coating layer in an area corresponding, and electrically coupled, to the first electrical-contact region; an electrical-contact pad, which extends over the first coating layer, electrically coupled to the first conductive through via; a third semiconductor body, integrating an electronic circuit, glued on the first coating layer; a second coating layer, made of resin, which englobes and protects the third body; at least one second conductive through via, which extends completely through the second coating layer in an area corresponding, and electrically coupled, to the electrical-contact pad; and a further electrical-contact pad electrically coupled to the second conductive through via.
US09446936B2	Pneumatically operated opener device A pneumatically operated opener device includes a holding unit, an air valve unit, an air injection unit, and a mounting member. The holding unit includes a hollow grip and a high pressure nitrogen bottle. The air valve unit includes a valve seat and a compressed nozzle module. The air injection unit includes a hollow air duct, a hollow push rod, and an air injecting needle. The mounting member has a through hole and a hollow slot, and the hollow push rod of the air injection unit is extended through the through hole of the mounting member. Thus, the cork is pushed upward by the thrust force of nitrogen from the high pressure nitrogen bottle and is detached from the wine bottle smoothly so that the cork will not be broken and will not produce chips during the opening process.
US09446930B2	Emergency stop device with attached hand brake system Disclosed is an emergency stop device with an attached hand brake system. The emergency stop device with the attached hand brake system comprises: brake units which are equipped on both sides of a car and control the movements of the car by selectively interfering with guide rails; an operation unit which is connected with the brake units and manually grants braking power to the braking units; and an interlocking unit which interlocks the brake units.
US09446928B2	Inertia braking payout device and package system A payout device is provided, wherein the payout device includes a carton, an elongated rotatable member and a support assembly. The carton has a plurality of panels enclosing an interior compartment. At least one panel has an opening providing an egress for elongated flexible material stored within the interior compartment. The elongated member is rotatably supported in a substantially horizontal direction within the carton by the support assembly. The support assembly has a slot with a generally teardrop shape. The teardrop shape has a larger diameter end and a smaller diameter end such that a portion of the rotatable member is slidable therebetween. The larger diameter end is sized to allow the rotatable member to rotate, and the smaller diameter end has a size smaller than the circumference of the rotatable member. The slot is positioned on the carton with the larger diameter end being elevated and closer to the opening than the smaller diameter end.
US09446927B2	Method and system for processing printed sheets, especially sheets of printed securities, into individual documents There is described method of processing printed sheets (100), especially sheets of printed securities, into individual documents (150), such as banknotes, each printed sheet (100) comprising an array of imprints arranged in a matrix of rows and columns. The method comprises the following steps : (i) pre-processing the printed sheets (100) by partly slitting each printed sheet (100) row-wise or column-wise to form slits (110) between adjacent rows or adjacent columns of imprints, slitting being performed in such a manner that the adjacent rows or adjacent columns of imprints are still attached to one another at edges of each thus pre-processed printed sheet (100′); (ii) stacking the pre-processed printed sheets (100′) so as to form sheet stacks (121, 122) comprising a predetermined number of pre-processed printed sheets (100′) stacked one upon the other; and (iii) processing the sheet stacks (121, 122) by cutting each sheet stack (121, 122) column-wise or row-wise along cutting lines (115) between adjacent columns or rows of imprints, cutting being performed along a direction perpendicular to the direction of the slits (110) and in such a manner that individual documents (150) are produced as a result. Also described is a system for carrying out this method.
US09446925B2	Medium processing apparatus and financial device The medium processing apparatus comprises a stacking surface on which a medium is stacked, first and second transfer rollers for transferring the medium to be stacked onto the stacking surface, a sheet roller for hitting the medium transferred by the first and second transfer rollers, and a rotation shaft to which the sheet roller is connected. The sheet roller comprises a body part connected to the rotation shaft and a contact part extending from the body part, and at least one portion of the body part of the sheet roller is disposed above the stacking surface.
US09446922B2	Sheet transporting apparatus and image forming system A sheet transporting apparatus is provided, including a transport mechanism provided with a roller, a motor, a controller, and a measuring input unit, wherein a transport route has a curved area for inverting the sheet, and the controller is constructed such that the control on the motor is executed by a closed loop control system by using a measured value of an control output at an initial stage of the transport of a sheet from a tray, and the control on the motor is switched from the control performed by the closed loop control system to control performed by an open loop control system on condition that a preset phenomenon arises after the sheet is taken out of the tray.
US09446921B2	Sheet processing apparatus having first and second aligners controlled based on combination of predetermined job parameters, and image forming system having sheet process apparatus A sheet processing apparatus including: a first aligner to push lateral edges of a sheet inward across a width direction of the sheet conveyed from an upstream side for alignment of the sheet, the width direction being orthogonal to a moving direction of the sheet; a second aligner to abut a front edge of the sheet conveyed from the upstream side for a predetermined period of time for alignment of the sheet; a first aligner driver to drive the first aligner; a second aligner driver to drive the second aligner; and a controller to control operations of the first aligner driver and the second aligner driver, wherein the controller activates or inactivates the first aligner driver and the second aligner driver depending on a predetermined parameter on the conveyed sheet.
US09446920B2	Sheet conveying device A slider moving in a sliding direction between first and second positions shifts a second path-defining member, relative to a first path-defining member, between first and second states. A pair of movable members each disposed on a corresponding side of a slider in a width direction is movable individually in the sliding direction to shift between third and fourth states. The movable members, when both in the third state, position the slider to the first position and, when both in the fourth state, position the slider to the second position. Each movable member supports a corresponding widthwise end of the slider immovably in the sliding direction and movably in the width direction. A support frame supporting the second path-defining member supports a widthwise central portion of the slider movably in the sliding direction and rotatably on a plane parallel to the sliding direction and the width direction.
US09446919B2	Push-pull latch assembly for a detachable media pick mechanism A push-pull latch assembly for a detachable media pick mechanism. The latch assembly comprises a handle that is slidably and axially insertable into a handle base which is mounted to the pick mechanism housing. The handle base includes a pair of cantilevered, opposed latched arms having opposed catches for engagement with a groove positioned adjacent to a free end of a cantilevered drive shaft for the pick mechanism. The handle includes triangular rails having inner and outer ramps used to separate the opposed latch arms. The outer ramp separates the latch arms when the handle is inserted into the handle base. The inner ramp separates the latch arms during removal of the pick mechanism from the drive shaft. An axial pushing force engages the latch assembly to the groove and an axial pulling force disengages the latch assembly from the groove allowing for pick assembly removal.
US09446917B2	Palletising device A palletizing device (10) comprising a lower plane (15) able to supportingly receive a pallet (5) and a loading device (100) vertically mobile above the lower plane (15) and comprising an upper platform (110), superposed in plan view on the lower plane (15) and provided with variable-configuration support means (112) and activating means able to cyclically move the support means (112) between a closed configuration, in which the define a support for a first layer of products (4) to be palletized, and an open configuration, in which they remove the support in order to release the first layer of products (4) downwards, in which the loading device (100) comprises a storing platform (120) defining a support for a second layer of products (4) to be palletized and flanked to the upper platform (110).
US09446913B2	Powder conveyance device and char recovery apparatus A powder conveyance device and a char recovery apparatus are each provided with: an inclination part serving as a powder discharge line which can convey char at a predetermined tilt angle by allowing the char to fall by gravity; a first porous plate having a predetermined opening ratio and being disposed along the inclination part; a second porous plate having a higher opening ratio than the first porous plate and being disposed along the inclination part at a position above the first porous plate; and an assist gas feed device for feeding assist gas to the inclination part through both the first porous plate and the second porous plate.
US09446908B2	Conveying systems and methods of associating data with an item transported by a conveying system Systems and methods of associating data to an item being transported by a conveying system are disclosed. The item and data associated with the item are received at a first zone of the conveying system. The data is stored in a first computer-readable storage medium associated with the first zone. The item is transported to a second zone of the conveying system, and the data stored in the first computer-readable storage medium is transferred to a second computer-readable storage medium associated with the second zone.
US09446907B2	Zone controller and conveyor device An object of the invention is to provide a zone controller and a conveyor device which facilitate identification of a defective part when a defect occurs in a distributed control type conveyor device. There is provided a zone controller (10) which is used for a conveyor device (1) in which a plurality of zone conveyors (2) are arranged in series, which manages one or a plurality of the zone conveyors (2) to control an operation thereof, and which is configured to receive a signal from a different zone controller (10) and transmit a signal to the outside. The zone controller (10) includes: a signal creation function that creates a predetermined abnormality alarm signal and transmits the created abnormality alarm signal to the outside when an abnormality occurs in a zone managed by the zone controller itself; a signal reception function that receives the abnormality alarm signal from the different zone controller (10); a signal processing function that applies certain processing to the received abnormality alarm signal; and a processed signal transmission function that transmits the signal processed by the signal processing function to the outside as the abnormality alarm signal.
US09446906B2	Spindle conveyor, and workpiece treatment station comprising the same A spindle conveyor for conveying workpieces, in particular vehicle wheels, having a rail system that includes at least one support rail. Multiple conveyor carriages have a chassis that can be moved on the support rail in a conveying direction and a supporting device for workpieces which is entrained by the chassis. Each workpiece can be mounted on a workpiece spindle which is part of the supporting device which has a pair of workpiece spindles mounted so as to be rotatable as a unit relative to the chassis about a vertical axis of rotation and can be moved at least into a first rotational position and a second rotational position. Also a station for treating workpieces, in particular vehicle wheels, with such a spindle conveyor which allows the workpieces to be conveyed through the station.
US09446905B2	Feed device and method An apparatus (1) for feeding components has a downwardly inclined guide path (6), a mobile component carrier (4), which is connected in a releasable manner to the guide path (6), and interacting rolling bodies and rails (15, 16) on the guide path (6) and on the component carrier (4). The feed apparatus (1) has a loading location (10), at which a component carrier (4) is connected to the guide path (6), and possibly loaded with one or more components (3), by a worker (12), using a manually operable transfer apparatus (14), which can be actuated by applying manual force counter to a restoring element (31, 40). The transfer apparatus (14) is designed as a preliminary-positioning apparatus (20) for a loose component carrier (4).
US09446903B2	Conveying apparatus Provided is a conveying apparatus configured that a rope member is extended between pulleys and a work is suspended on a rope member through a hook member. The object of the present invention is to provide the conveying apparatus making the rope member hard to come off the pulleys and including a bend part. The conveying apparatus for conveying the work along a predetermined conveying route includes a plurality of pulleys, a rope member, and a support member. The hook member is flexible, including a hold part which is a hole into which the rope member is inserted, held by the rope member by inserting the rope member into the hold part. The support member is joined to the hook member, and is suspended on the rope member by inserting the rope member into the hold part.
US09446901B2	Storage device A storage device includes: a storage member having, in the vertical direction, a plurality of parallel storage sections that are capable of storing plate-like members; and a first lifting and lowering mechanism that causes the plate-like members, stored in the storage member, to move integrally in the vertical direction, while the position of the storage member in the vertical direction is maintained.
US09446892B2	Protective enclosure for transporting an automobile door A protective enclosure for transporting an automobile door includes an elongated, generally U-shaped main body having a pair of opposing side panels connected along a bottom edge by a bottom panel. A plurality of padded elements are located along the inside facing surfaces of the main body, and multiple inelastic straps are located along the outside edges of the main body. The straps including connectors for selectively engaging each of the opposing side panels.
US09446888B2	Multi-compartmented flowable-foodstuff storage container plus dispenser and related methods Disclosed is a multi-compartmented storage container for storing two or more flowable materials in separate compartments so that the materials may be poured from the container individually or combined.
US09446887B2	Neck extender and grip promoting devices and systems Devices and systems for facilitating a user's grip around the neck of a bottle such that the contents of the bottle may be poured quickly and efficiently, with minimal stress on the use's body. Furthermore, such systems and methods may be configured to extend the neck of a bottle such that an attached pour spout is positioned at a desired height. Such a device may comprise a body to couple with the neck of the bottle, the body having an exterior surface configured to facilitate a secure grip therearound.
US09446883B2	Fall arrest safety net A wire mesh safety net for enclosing an overhead device fabricated from a wire strand formed into a bag and having a closed bottom and an open mouth with a line engaging the open mouth for opening and closing the bag around the device and having wire mesh extending and retracting structure for increasing and decreasing the extent of the wire mesh bag.
US09446882B2	Dual chamber container structure A portable milk warmer that is suitable for use with vessels, such as ampules, bags or bottles, enclosing chilled or frozen liquids, such as breast milk. The portable milk warmer includes separate chambers in a single container that separates the vessel from a warming (or cooling) medium. The milk warmer includes a feature for filling an outer chamber with a warming or cooling medium.
US09446879B2	Container end closure with optional secondary vent opening The present invention relates to an opening device for a beverage container. More specifically, the invention relates to a metal end closure having a primary opening area and at least one optional secondary vent opening which can be opened with the same pull tab. The primary opening area of the metal end closure may be opened by utilizing a pull tab interconnected to a central panel, the pull tab being adapted for applying a downward force to form a first opening. Subsequently, the pull tab is rotated and the tail end lifted to form a second opening in the end closure.
US09446878B1	Low scrap tray A low scrap tray is constructed from a single sheet of material to act as a retail display tray, reducing the waste from traditional container construction processes. The low scrap tray includes a bottom panel, a front panel, a rear panel, a left panel, a right panel, a left inward rim, a right inward rim, a front-left flap assembly, a front-right flap assembly, a rear-left flap assembly, a rear-right flap assembly, a front opening, and a top opening. The front panel, the rear panel, the left panel, the right panel, the front opening, the left inward rim, the right inward rim and the top opening define a storage space when the low scrap tray is operatively configured. The front-left flap assembly, the front-right flap assembly, the rear-left flap assembly, and the rear-right flap assembly secure the positioning of front panel, the rear panel, the left panel, and the right panel.
US09446877B1	System and apparatus for applying labels to cable or conduit A system for applying labels to cable or conduit including at least one label and a label applicator. The label applicator including at least one guide roller, at least one tamping device comprising at least one tamping pad for applying at least one label onto the moving cable or conduit, and a guide shoe assembly. The guide shoe assembly comprises a guide shoe, the guide shoe comprises a rounding member, a plurality of springs for providing flexibility to the rounding member when the moving cable or conduit passes the at least one guide shoe, a support mount for supporting the at least one guide shoe, a plurality of pivots disposed between the rounding member and the rounding member support for adjusting the set of springs, and a fitted member for providing an anchor for the at least one guide shoe to connect with the support mount.
US09446871B2	Trolley and method of using the trolley for vertical rolling A trolley for supporting the plate during vertical rolling of the plate is provided. In one embodiment, the trolley can include a support body configured to provide support for the trolley; a plurality of wheels configured to allow the trolley to move across a floor; a lifting arm supported by the support body, wherein the lifting arm is movable about a first position and a second position; a pump handle configured to raise the lifting arm between the first position and the second position; and a plate holder configured to move with the lifting arm and hold the plate in place relative to the trolley.
US09446866B2	Bagging machine suitable for all types of dry and wet grain The invention relates to a machine formed by a grain-holding box containing a combination of two transverse plates, namely a front vertical plate that closes the box and another plate which is solidly connected to the front plate halfway along the length thereof, inclined at 45 degrees, projected forward and integrally welded to the structure of the machine. In addition, the running gear includes a back axle provided with a single shaft connected at the ends thereof to a pair of wheels, plus at least one crown wheel, and said at least one crown wheel is in turn linked by means of a transmission chain to at least one gear mounted on the ends of a control rod of an integral clutch device linked by another transmission chain to a hydraulic motor, with the actuation and control means thereof.
US09446865B2	Method for producing a water-soluble detergent pouch with a graphic printed thereon A method for on-line printing onto water-soluble film on-line with water-soluble detergent pouch process.
US09446862B2	Cryogenic thruster assembly using regenerative heating from main and settling thrusters A cryogenic thruster assembly including: a reignitable main thruster; a first cryogenic tank connected to the main thruster to feed the main thruster with a first propellant; a first gas tank; at least one settling thruster; and a first feed circuit for feeding the first gas tank. The feed circuit of the first gas tank is connected to the first cryogenic tank and includes a heat exchanger for using heat given off by the at least one settling thruster to vaporize a liquid flow of the first propellant as extracted from the first cryogenic tank to feed the first gas tank with the first propellant in the gaseous state. A method feeds the first gas tank with the first propellant in the gaseous state.
US09446853B2	Method and apparatus for monitoring the wing anti-icing valve The present invention relates to a system for monitoring the wing anti-icing valve, comprising: time record device configured to record the time for opening or closing the anti-icing valve; data acquisition device configured to obtain the time for opening or closing the anti-icing valve recorded by the time record device; and message generation device configured to generate the anti-icing valve performance message according to the time for opening or closing the anti-icing valve obtained by the data acquisition device.
US09446850B2	Heat exchanger incorporated into a wall of an aircraft An aircraft includes at least one wall delimiting a first zone (I) of the aircraft which is thermally insulated from the outside of the aircraft and a second zone (E) contained within the aircraft which is not thermally insulated with respect to the outside of the aircraft and a heat exchanger inside which a heat transfer fluid circulates, wherein the wall includes at least one duct inside which the heat transfer fluid circulates so as to act as a heat exchanger.
US09446838B2	Systems for inceptor control in fly-by-wire aircraft systems Aircraft, control-by-wire systems, and controllers are provided. The aircraft includes a flight control surface and a control-by-wire system. The control-by-wire system includes an input device and a controller. The input device is configured to control the flight control surface. The controller is communicatively coupled with the input device and configured to automatically offset a neutral force position of the input device based on a deviation of the aircraft from a reference condition while the aircraft is operated in a manual flight mode.
US09446834B2	Self-stiffened skin for aircraft fuselage including stringers with a closed section and associated manufacturing method Simplification of the manufacture of composite material fuselages for aircraft, as well as mass reduction of fuselage sections and space optimization inside such fuselage sections. To accomplish this, it is proposed to use stringers of a new type which have a closed transverse section, and which are thus able to be self-positioned relative to one another by being positioned edge-to-edge on a stringer supporting structure, such as the outer surface of a mandrel. The installation of the stringers in grooves of conjugate shape is by this means made unnecessary. The stringers have cut-outs located between circumferential frames, and are able to house utility systems.
US09446832B2	Apparatus and method for the control of engine throttle for inboard and outboard boat motors A ski boat throttle control system incorporating a rotary assembly such as a thumbwheel within the control lever knob which is part of the control lever assembly that is gripped and held by the operator of the boat during use. The incorporation of such a thumbwheel assembly allows the operator to make more controlled adjustment to the speed of the boat when the boat is in normal operational mode and to intuitively make adjustments to the cruise control speed of the boat when in cruise control.
US09446824B2	Boat Bunk The boat bunk includes an elongate beam, generally rectangular in cross-section, which beam includes a rigid inner core (1) and a resiliently deformable outer layer or shell (2) covering the core (1). The upper side of the outer layer or shell (2) defines the working surface. The working surface is provided with dome shaped raised protrusions (2a). The inner core (1) is made of unplasticized polyvinyl chloride (UPVC) or hardwood. The inner core (1) is reinforced with metal rods, strips or angled iron strips (7). The outer layer (2) is molded onto the inner core (1). The boat bunk includes fastening means for fastening the boat bunk to a trailer.
US09446821B1	Port and plug system for subsea equipment The system for sealing subsea equipment includes a port tube, having a test port hole and a curved slot, a test port plug mounted in the test port hole, an insert body having an insertion tip portion, a middle sealing portion, and a base portion, an insert stem engaged to the base portion, a top cap engaged to the insert body, and a sealing device mounted around the insert body and in sealing engagement with the port tube. A locked configuration corresponds to a locking arm of the top cap at a terminal end of the curved slot. A set configuration corresponds to compression of the sealing device by actuation of the insert body by the plug stem. The sealing device aligns with the test port plug in the set configuration so as to allow verification of sealing engagement of each seal ring and the port tube.
US09446819B2	Method for discharging liquid from a tank of a stricken ship This method for discharging liquid from a tank of a stricken ship that is partially out of the water and has at least one technical access includes the following steps: opening the technical access, introducing a rigid pipe into the interior of the tank through the technical access, and placing a lift pump or a suction pump inside the rigid pipe. The lift pump or suction pump can be without a delivery hose.
US09446814B2	Bicycle brake arm A bicycle brake arm includes a sleeve, a brake arm body, first and second abutments and first and second bearing members. The brake arm body has a mounting portion and is rotatably arranged with respect to the sleeve. The first and second abutments are axially arranged with respect to each other on the sleeve. At least a part of the brake arm body is disposed between the first and second abutments. The first bearing member is disposed axially on a first outside of the mounting portion of the brake arm body. The second bearing member is disposed axially on a second outside of the mounting portion of the brake arm body. The first bearing member is axially disposed between the first and second abutments. One of the first and second bearing members includes a roller bearing and the other of the first and second bearing members includes a dry bearing.
US09446808B2	Bicycle saddle Provided is a bicycle saddle wherein the seat is made from a resin base alone without using a shock-absorbing pad and the conflicting properties of softness/comfort and strength/rigidity can be balanced. The saddle comprises a main saddle body and a rail member for mounting the main saddle body on a frame. The main saddle body is configured from a frame member made of a first synthetic resin in which multiple through holes are formed, and a mesh member made of a second synthetic resin that is laminated on the upper surface of the frame member and in which multiple through holes are formed in a mesh pattern. The second synthetic resin of the mesh member is selected from nylon, polyethylene and polypropylene. The first synthetic resin of the frame member is a synthetic resin such as a glass fiber-reinforced synthetic resin with a higher rigidity than the second synthetic resin.
US09446802B2	Track pad The present invention relates to a track pad for a chain of a chain wheel drive, the track pad having a bearing surface provided with at least one grouser (1, 2), extending in the lateral direction of the bearing surface, wherein at least one flat part (4, 5) is provided next to at least one grouser part (1, 2) in the lateral direction of the bearing surface. Further, the invention comprises a track pad for a chain of a chain wheel drive, the track pad having a bearing surface provided with at least one grouser (32, 33) protruding from a base plate (40), the grouser (32, 33) extending in the lateral direction of the bearing surface, wherein the bearing surface of the base plate has a profile in the lateral direction.
US09446800B2	Vehicle cross-support member with hybrid metal joint There is provided in a preferred embodiment a vehicle cross-support member for positioning in a generally transverse orientation to a length of a vehicle, the cross-support member including a jointed portion extending from a first end to a second end, wherein the jointed portion includes a first elongated member and a second elongated member mechanically coupled to the first elongated member. The first elongated member includes an axially open socket end portion, and the second elongated member includes a mating end portion sized for fitted placement within the socket end portion in frictional engagement therewith in a mechanically coupled position.
US09446799B2	Support used as a chassis component The invention relates to a support (2, 3) used as a vehicle component and comprising a longitudinal extension which corresponds to a multiple of the transverse extension thereof. Said support (2, 3) comprises a reinforced transverse profile section. For this purpose, the support (2, 3) comprises at least one reinforced element (7, 8) which follows the longitudinal extension of the support (2, 3), is connected to the support in a positive and material fit manner and in a tension and shear-resistant manner, with the insertion of a separation layer (12) between the longitudinal extension of the support (2, 3).
US09446798B2	Vehicle hood structure A vehicle hood structure, which includes an outer panel that forms an outer surface of a vehicle, an inner panel that is disposed below the outer panel and fixedly attached to the outer panel and that has a plurality of beam portions extending in a longitudinal direction of the vehicle, having a hat-shaped section opening downward, and being separated from each other in a lateral direction of the vehicle, and which covers a front part of the vehicle, the vehicle hood structure including: a reinforcing member that is disposed below the inner panel so as to extend in the lateral direction of the vehicle and to have clearance between the reinforcing member and the beam portions, that has a convex shape curved upward in the lateral direction of the vehicle, and that is fixedly fastened at its both ends in the lateral direction of the vehicle to the inner panel.
US09446791B2	Refined row guidance parameterization with Hough transform Systems and techniques for refined row guidance parameterization with Hough transform are described herein. An electronic representation of a field (ERF) can be received. A steering variable calculation can be performed by executing a cascaded Hough transform on the ERF. An intermediate value used in calculating the steering variable can be selected. A refined intermediate value can be identified from the intermediate value by measuring a difference between the intermediate value and an anchor value. The steering variable calculation can be adjusted using the refined intermediate value.
US09446781B2	Steering system In a steering system configured such that occurrence of a half lock is suppressed, when a body portion of a tooth member is pressed in a lock operation of locking the position of a steering column, the tooth member is extended to move a pair of second tooth row forming portions away from each other obliquely with respect to a lateral direction of an elongate tilt hole along the outer surface of a fastening side plate.
US09446774B2	Railway car truck with friction damping A three piece railway freight truck is comprised of two laterally spaced side frames between which a bolster extends. Suspension load springs support the bolster, and control springs support friction shoes. Both variations of friction shoes have gaps that will allow lateral movement of the friction shoes across the bolster or the friction shoes across the side frame. The lateral movement is accomplished by having a low friction material pad between the bolster and the friction shoe or a low friction material pad between the friction shoe and a wear plate that bears on the side frame. The low friction material with low siding resistance allows lateral displacement energy to be dissipated over the lateral decoupling clearance.
US09446767B2	Travel controller for vehicles A running control device of a vehicle includes an engine with a plurality of cylinders, and a clutch connecting/disconnecting a power transmission path between the engine and wheels, the running control device of a vehicle performing during an inertia running mode a neutral inertia running mode performed with the power transmission path between the engine and the wheels disconnected while the engine is kept operated, and a cylinder resting inertia running mode performed by resting at least a part of the cylinders of the engine while the power transmission path between the engine and the wheels is connected, the running control device of a vehicle increasing an operation region of performing the neutral inertia running mode in an operation region of performing the inertia running mode when idle learning performed in an idle operation state of the engine is incomplete, as compared to after completion of the idle learning.
US09446765B2	Systems and methods for identifying relevant traffic lights Systems and methods use cameras to provide autonomous navigation features. In one implementation, a system includes at least one image capture device configured to acquire at least one image of an area forward of the vehicle. The area includes a plurality of traffic lamp fixtures each including at least one traffic light. The system further includes at least one processing device configured to use at least one indicator of vehicle position, as determined from the at least one acquired image, to determine a relevance to the vehicle of each of the plurality of traffic lamp fixtures. The at least one processing device may determine, based on the at least one acquired image, a status of a traffic light included in at least one traffic lamp fixture determined to be relevant to the vehicle, and cause a system response based on the determined status.
US09446762B2	Shift control apparatus and method of hybrid vehicle A shift control system and method of a hybrid vehicle are provided and controlled by dualizing a brake shift pattern based on whether an engine clutch release is possible when a hybrid vehicle brake is engaged. The system includes a hybrid controller that is configured to detect whether engine clutch release is possible, based on battery state information and input data from a operation. In addition, a shift controller is configured to execute a gear shift by a brake shift pattern based on whether the engine clutch release is possible.
US09446760B2	Vehicle drive device A vehicle drive device having a control device making another first planetary gear device constituent member and a second planetary gear device constituent member non-rotatable by a brake to perform electric motor running for running with power of a second electric motor while an engine is put into a non-drive state, when the engine is started during the electric motor running the control device causing a first electric motor to rotate the engine while the other first planetary gear device constituent member and the one second planetary gear device constituent member are kept non-rotatable by the brake, and when the brake is released after start of the engine, the control device controlling the first electric motor before release of the brake so a torque applied to the brake due to power of the engine reaches a magnitude balancing with a torque applied to the brake due to a running load.
US09446758B2	Hybrid vehicle and method for setting specifications of engine and motor/generator in hybrid vehicle A hybrid vehicle (100) is a parallel hybrid vehicle including a motor/generator (5) arranged between an engine (1) and a transmission (62). The engine (1) is configured to perform lean operation in a low-load operating range. The hybrid vehicle is configured such that a rotation speed at a maximum point of power generation efficiency of the motor/generator (5) is within a rotation speed range (Xa) corresponding to a lower-speed part (a) of a 95% fuel-consumption efficiency operating range (A) of the engine (1).
US09446757B2	Active motor damping control of a hybrid electric vehicle powertrain A hybrid electric vehicle includes an engine and an electric motor both configured to generate a vehicle powertrain torque and a controller programmed to control the powertrain torque for a limited duration in anticipation of a powertrain torque variation scenario using a damping function, wherein the damping function adjusts the vehicle powertrain torque based on a difference between a measured motor speed and a desired motor speed using the electric motor to counteract a powertrain speed oscillation.
US09446756B2	Power system of hybrid electric vehicle, hybrid electric vehicle comprising the same and method for heating battery group of hybrid electric vehicle A power system of a hybrid electric vehicle, a hybrid electric vehicle comprising the same and a method for heating a battery group of the hybrid electric vehicle are provided. The power system includes: a battery group; a battery heater connected with the battery group; a battery management device configured to control the battery heater to heat the battery group with a first power or a second power when the hybrid electric vehicle is in an electric vehicle mode or a hybrid electric vehicle mode, when the temperature of the battery group is lower than a first heating threshold and a residual electric quantity of the battery group is larger than a parking electric quantity threshold; an electric distribution box; an engine; a motor; a motor controller connected with the motor and the electric distribution box respectively; and an isolation inductor.
US09446755B2	Steering system A vehicle steering system includes: a steering wheel having the capacity to steer a vehicle; a turning actuator having the capacity to turn a wheel; a backup clutch arranged between the steering wheel and the turning actuator and having the capacity to be able to mechanically connect the steering wheel to the turning actuator; and a clutch disengagement checking unit having the capacity to check whether the backup clutch is disengaged.
US09446754B2	System and method of controlling starting of vehicle A system of controlling starting of a vehicle may include a vehicle speed sensor detecting vehicle speed, an accelerator pedal position sensor detecting position of an accelerator pedal, a brake pedal position sensor detecting when a brake pedal may be operated or not, a distance sensor detecting a distance from a previous vehicle, a timer detecting time lapse from particular time, and a controller electrically connected to the vehicle speed sensor, the accelerator pedal position sensor, the brake pedal position sensor, the distance sensor and the timer, and adapted to change starting pattern according to the distance from the previous vehicle and to perform starting control according to the changed starting pattern when the vehicle may be started in a stopped state.
US09446753B2	Brake actuating unit A brake actuating unit (1, 1′) for a brake-by-wire motor vehicle brake system having a housing (10), a first hydraulic cylinder/piston arrangement (3) to which a plurality of wheel brakes connectable. The piston being operable by a push rod (2) transmitting an actuating force, an electrically controllable pressure supplying device (6) in the form of a second hydraulic cylinder/piston arrangement (12), actuated by an electric motor (7). A number of valves (41, 42, 43) for setting wheel-individual brake pressures and for disconnecting or connecting the wheel brakes with the first or the second cylinder/piston arrangement (3, 12). The valves and the second cylinder/piston arrangement are arranged at least partially inside the housing (10), the axis of the electric motor (7) being arranged substantially perpendicular to the longitudinal axis (30) of the first cylinder/piston arrangement (3).
US09446751B2	Vacuum brake force booster with reduced noise emission and method for manufacturing a vacuum brake force booster of said type A vacuum brake force booster for a motor vehicle brake system comprising: a force input member which is movable along a longitudinal axis and which is or can be coupled to a brake pedal, a control valve arrangement which can be actuated by the force input member, a chamber arrangement which is arranged in a housing and which has at least one working chamber and at least one vacuum chamber separated from one another by means of a movable wall and which has a force output member for transmitting an actuating force, wherein the at least one working chamber can be connected selectively to a vacuum source or to the atmosphere, wherein the control valve arrangement has a control valve housing which is coupled to the at least one movable wall for conjoint movement therewith, wherein the control valve arrangement has a force-transmitting arrangement which has a degree of axial play and which is arranged in the force transmission path between the force input member and the force output member. Here, for noise reduction, it is provided that at least one component of the force-transmitting arrangement is manufactured from magnetic or ferromagnetic material and is subjected to a permanently applied magnetic field.
US09446742B1	Apparatus and system for air-borne cleaning of surfaces There is provided a system and method of cleaning surfaces of an interior cabin space of a contamination comprising a microbial and viral load. The method includes the steps of sealing the interior cabin space and placing water, and a solid or gel pack, into a container and generating a vortex the container by rotating an impeller. The agitation causes the solid or gel pack to release a gaseous cleaning agent. An air-borne spray exiting from the container spreads throughout the interior cabin space to coat the surfaces to be cleaned within the interior cabin space. The cabin is maintained closed for an effective time period while the coating from the air-borne spray dwells on the surfaces to eliminate or substantially reduce the load of the contamination.
US09446734B2	Illuminated emblem assembly for connection to an airbag cover Multi-piece constructions for an illuminated emblem assembly for connection to an airbag cover are provided herein. An airbag assembly can include an airbag cover, an emblem portion having one or more translucent areas and an illumination source. The illumination source can include a light guide and one or more light emitting diodes (LEDs) for illuminating the light guide. The light guide can include an illuminated portion for transmitting light emitted from the one or more LEDs. The emblem portion can be arranged between the airbag cover and the illumination source, and the emblem portion and the illumination source can be aligned such that at least one of the one or more translucent areas is illuminated by light passing through the emblem portion from the illuminated portion.
US09446730B1	Automatic passenger airbag switch Techniques described herein include a system and method for switching an airbag on or off based on determining that an object situated in a vehicle seat meets one or more conditions. In some embodiments, the vehicle seat may be fitted with a weight sensor configured to detect an object situated in the vehicle seat. The system may include a camera device configured to capture image information associated with the object situated in the vehicle seat. The image information may be processed to determine if the object is a person meeting one or more threshold conditions for activating the airbag. Upon processing the image information, the airbag may be provided with instructions to either activate or deactivate.
US09446727B2	Flexible interior mount fascia bracket A bracket is provided that may be welded to the interior surface of a vehicle fascia. The bracket has a flange and a mounting boss. The flange is slotted to form flexible fingers that conform to the interior surface of the fascia. The fingers are welded to the fascia to attach the bracket to the interior surface of the fascia. A vehicle component, such as an impact sensor, is attached to the mounting boss to secure it to the fascia.
US09446726B2	Vehicle braking deployment logic for pedestrian protection leg stiffener A method and apparatus for controlling a deployable pedestrian protection leg stiffener of a motor vehicle based upon the vehicle braking status and longitudinal acceleration.
US09446722B2	Elastic averaging alignment member An elastic averaging alignment member includes a base portion, a first elastic averaging member including a first end portion extending substantially perpendicularly from the base portion to a second end portion and a second elastic averaging member spaced from the first elastic averaging member. The second elastic averaging member includes a first end section extending substantially perpendicularly from the base portion to a second end section. At least one elastic averaging element arranged between the first and second elastic averaging members. At least one of the first and second elastic averaging members and the at least one elastic averaging element is configured and disposed to deform when the elastic averaging alignment member is passed into an alignment member receiver to establish an elastically average position of one component to another component.
US09446717B2	Multi-purpose rack and method thereof A multipurpose rack comprising a first racking assembly including a first securing portion configured to secure a first portion of a first transportation device, and a second securing portion operably connected to the first securing portion configured to releasably secure a second portion of the first transportation device, a second racking assembly including a first end portion having a clamping assembly, wherein the first end portion includes a lower support frame, a second end portion operably connected to the first end portion and spaced apart from the first end portion, the second end portion removably enclosing another portion of the second transportation is provided. An associated method is also provided.
US09446714B2	Sliding conversation mirror assembly with friction tabs for vehicle overhead console A vehicle overhead console is provided which includes a conversation mirror assembly having a housing capable of storing a conversation mirror. The conversation mirror may travel between a stored and a use position. The conversation mirror is releasably secured to the stored and use positions by way of magnetic, tab, and spring arrangements.
US09446712B2	Motor vehicle comprising an electronic rear-view mirror A motor vehicle has at least one electronic rearview mirror, particularly an exterior and/or side mirror, that has an indicator apparatus, particularly a display, for images recorded by an exterior camera that is provided particularly outside the motor vehicle. The indicator apparatus is in the form of a touchscreen, particularly one with multitouch capability.
US09446711B2	Driving assist device Provided is a driving assist device 10 that recognizes an object in the vicinity of a moving body, and assists a driver in driving the moving body, the apparatus including: an object detecting unit 12 that detects the object in the vicinity of the moving body; a three dimensional object detecting unit 13 that detects a three dimensional object in the vicinity of the moving body; and an object recognition unit 18 that recognizes the object at a predetermined detection position as a non-obstacle when the object information storing unit 16 stores the position of the object, and the three dimensional object information storing unit 17 does not store the position of the three dimensional object at the predetermined position in which detection is performed by both of the object detecting unit 12 and the three dimensional object detecting unit 13.
US09446699B2	Footrest for construction machine operating room Disclosed is a footrest for an operating room on which the operator can rest his foot in order to balance his body when he is operating in the operating room, or working on a slope, etc. The footrest for a construction machine operating room according to the present invention includes: a footrest support having one end pivotably attached to a front pillar member of the operating room by means of a hinge pin; a fixing grip arranged on the pillar member below the hinge pin so as to detachably fix the footrest support; and a fixing pin fastened to a bracket arranged at the pillar member to hold the footrest, the fixing pin being attached to the bracket so as to be moved forward and backward, so that the fixing pin may move forward to press the upper surface of the footrest support when pivoting the footrest support horizontally.
US09446692B2	Bearing for use in sliding head restraint The present disclosure relates to bearings, guide sleeves and head restraint assemblies for automobiles.
US09446686B2	Seating arrangement for a passenger vehicle A vehicle seating assembly includes a front seat and a rear seat, each having a backrest and a squab. The front and rear seats are arranged in a staggered duplex overlapping relationship. A portion of a front edge of the rear seat squab overlaps a portion of a rear edge of the front seat squab. An inboard edge of the rear seat squab overlaps a portion of an inboard edge of the front seat squab. A longitudinal distance measured from a front edge of the front seat squab to a rear edge of the rear seat squab is less than the sum of the longitudinal lengths of the front and rear seat squabs. A transverse distance measured from an outboard edge of the front seat squab to an outboard edge of the rear seat squab is less than the sum of the widths of the front and rear seat squabs.
US09446681B2	Flow uniformity of air-cooled battery packs A battery pack and method of cooling a battery pack. In one form, the battery pack is an assembly made up of numerous battery cells arranged within numerous modules. Cooling channels that receive cooling fluid from a ducted supply are placed between adjacent cells or cooling plates within each of the modules. The ducted supply includes beads or related area-increasing undulations that are designed to improve both the stiffness of the ducting as well as the uniformity of the flow rates of individual cooling channels within each of the modules. In one form, the pressure-enhancing beads are placed in an inlet portion of the ducting that is adjacent a forward portion of one or more of the sequentially-encountered modules in order to promote a more equitable distribution of the cooling fluid between the various cooling channels within each of the modules.
US09446677B2	Technique of determining degradation of high-voltage battery for vehicle Disclosed herein is a technique for determining degradation of a high-voltage battery of a vehicle. More specifically, variations in charge capacity with respect to a predetermined variation in voltage of a high-voltage battery that is currently being slowly charged are obtained depending on degradation degrees of the high-voltage battery. A vehicle equipped with a high-voltage battery having a specification identical to those of the high-voltage battery is used to acquire a charge capacity and a voltage of the high-voltage battery that is currently being slowly charged. A variation in charge capacity with respect to the predetermined variation in voltage is calculated from the charge capacity and the voltage. The variation in charge capacity with respect to the predetermined variation in voltage is compared with the variations in charge capacity with respect to the predetermined variation in voltage depending on the degradation degrees, thus determining a relevant degradation degree.
US09446676B2	Charging station for wired charging of electric vehicle A charging post at a charging station for charging an electric vehicle can be lowered into the ground by a lifting device such that it does not become a physical obstacle or optically impair the environment and is not damaged by external influences.
US09446674B2	Systems, methods, and apparatus related to mutual detection and identification of electric vehicle and charging station Systems, methods, and apparatus are disclosed for communicating with a charging system comprising a plurality of charging stations configured to charge an electric vehicle. At least one first signal is transmitted to the charging system via a first communication link while the electric vehicle is a first distance from at least one charging station of the plurality of charging stations. The at least one first signal is indicative of a vehicle identifier of the electric vehicle. At least one second signal is received from the at least one charging station of the plurality of charging stations via a second communication link while the electric vehicle is a second distance from the at least one charging station, the second distance less than the first distance. The at least one second signal is indicative of a charging station identifier of the at least one charging station.
US09446673B2	Charging port device for electric vehicle A lock mechanism, when a restricting member is being moved to a predetermined position which corresponds to one of a locked state or an unlocked state, imparts a torque, using a motor, to move the restricting member from an inner-side position near the predetermined position to the predetermined position using a toggle spring disposed between the restricting member and a vehicle body side.
US09446672B2	Charging systems for electric vehicles This disclosure provides systems and methods for charging a vehicle. A vehicle and charging station can be designed such that an electric or hybrid vehicle can operate in a fashion similar to a conventional vehicle by being opportunity charged throughout a known route.
US09446670B1	Energy generating system An energy generating system may comprise a plurality of airfoils rotating about an axis that is perpendicular to an axis along a flow of air, the airfoils being staggered in multiple rows perpendicular to the axis along the flow of air and across a top surface of a vehicle, and a plurality of generators each comprising a rotor and a stator, each stator configured to channel the airflow along the leading edge of the airfoils, each rotor connected to each of the plurality of airfoils, the rotor configured to generate energy by rotating around the axis, the energy converted into electrical power.
US09446668B2	Drive method with shifting of the switching frequency and drive device A method for driving a vehicle comprising at least two motors is provided. If a plurality of motors are fed from an intermediate circuit via inverters, the current in the intermediate circuit has a plurality of harmonics (−5th, −3th, −1st, +1st, +3rd, +5th). To prevent coupling capacitors of the intermediate circuit becoming over-burdened, the switching frequency of the inverters is shifted in such a manner that the harmonics no longer fall into a resonance range.
US09446667B2	Charging an electric vehicle and air conditioning of the vehicle interior A method is provided for charging an electric vehicle with an electric energy accumulator and for stationary mode air conditioning the vehicle interior by way of an electric air conditioning system. The electric energy accumulator is charged to a minimum state of charge. After the energy accumulator has reached the minimum state of charge, the interior is air conditioned in such a way that at an assumed departure time a preset air conditioning state of the interior is reached. The energy accumulator is charged to a target state of charge with any excess energy that is not required to reach the air conditioning state.
US09446664B2	PTO transmission system in a work vehicle A PTO transmission system in a vehicle for transmitting power to a PTO shaft driving an implement comprises a planetary drive unit having first and second input and output coupled to the PTO shaft. The first and second inputs are coupled to an output shaft of the vehicle engine and to an output shaft of a drive motor, respectively. A control system controls the transfer of power from a power source to the drive motor. The power source is a variable power generating source driven by the PTO shaft. The drive motor is configured and adapted to decrease or increase the rotational speed of the output of the planetary drive unit on an increase or decrease of the power transferred to it, respectively.
US09446659B1	Integrated chassis heatsink for electric vehicles A chassis for an electric vehicle is disclosed that functions as a heat sink to cool an electric motor and motor controller of the electric vehicle. The chassis includes one or more tubes that are connected to an inner surface of the chassis. As coolant fluid flows through the tubes, heat from the coolant is dissipated into the chassis.
US09446658B2	Agricultural tractor front end installation An agricultural tractor comprises an engine and a cooling package supported in front of a cab. The cooling package comprises a radiator and fan disposed between the engine and cab, the radiator having a major surface which is aligned longitudinally so that an airflow forced through the radiator by the fan is generally transverse with respect to the tractor's forward direction of travel. The orientation of the radiator provides for a narrower front end installation which improves the driver's field of view and relaxes limitations on steering angles and cooling package size.
US09446648B2	Gas spring and gas damper assembly with a releasable axial-locking assembly Gas spring and gas damper assemblies can include a gas spring that includes a flexible spring member, a first end member and a second end member that together at least partially define a spring chamber. A gas damper can include a first damper element and a second damper element that are telescopically engaged with one another for reciprocal motion. A releasable axial-locking assembly can be operatively connected between the first and second damper elements that is capable of operating in both locked and released conditions. Gas damper assemblies, suspension systems and methods of manufacture are also included.
US09446647B2	Vehicle suspension apparatus and method of assembling vehicle suspension apparatus A vehicle suspension apparatus includes: a shock absorber that has a cylinder outer tube; a dust cover whose upper area is fixed on an upper support side; and a coil spring that surrounds the dust cover. The outer tube has a first engagement unit provided on a portion of the circumference of the outer tube. The dust cover a second engagement unit provided on a portion of the circumference of a lower area of the dust cover. The second engagement unit becomes engaged with the first engagement unit. The first engagement unit provided around the outer tube and the second engagement unit provided around the lower area of the dust cover become engaged with each other by rotating the dust cover around the shaft of the shock absorber.
US09446644B2	Concentric knurl ball joint A replacement ball joint assembly (10) adapted to be pressed into a previously used and possibly distorted receiving hole (26) in a suspension component such as a control arm (28). A socket housing (12) of the assembly (10) includes a plurality of generally annular, concentric knurls (36) each having a respective crest portion (38) and separated one from another by intervening relief grooves (40). The crest portions (38) of the knurls (36) may be tapered so as to provide a lead-in feature to minimize misalignment during a press-in installation operation. The knurls (36) are preferably softer than the control arm material so that they yield during press-in rather than further disfiguring or enlarging the receiving hole (26). Displaced material from the crest portions (38) of the knurls (36) flows into the relief grooves (40).
US09446642B2	Rear axle of a two-track vehicle A rear axle of a two-track vehicle, including three control arms articulated to a wheel carrier and extending substantially in a transverse direction of the vehicle, and a trailing arm rigidly connected to the wheel carrier and having adequate flexibility in the transverse direction of the vehicle due to its structure or its mounting on the vehicle body. A support spring proportionately supporting the vehicle body with respect to the wheel and a vibration damper connected effectively in parallel with the supporting spring are supported on the wheel carrier without the intermediate arrangement of a control arm articulated to the wheel carrier. The support spring is supported in front of the wheel center and below the wheel center, as viewed in the direction of travel, on a cantilever protruding from the wheel carrier toward the vehicle center plane and the control arm articulated to the wheel carrier above the center point of the driven wheel in the vertical direction is connected to the wheel carrier behind the wheel center as viewed in the direction of travel. The control arm articulated to the wheel carrier in front of the wheel center as viewed in the direction of travel is connected to the wheel carrier below the wheel center in the vertical direction. The control arm arranged farthest to the rear as viewed in the direction of travel is connected to a steering actuator for the wheel by its end facing away from the wheel carrier.
US09446635B2	Universal tire pressure sensor A tire pressure sensor for motor vehicles, includes a housing, which accommodates an integrated circuit (sensor IC), having a microcontroller and a pressure sensor. The microcontroller transfers pressure measurement values to a separate receiver device by wireless communication. The sensor IC has an internal memory, in which executable instructions and data can be stored, which, when executed, result in the acquisition and transference of the pressure measurement data. A power supply is disposed in the housing, and coupled to the sensor IC which is coupled to an auxiliary memory module disposed in the housing. Numerous different data packets, with respective instructions or data, are stored in the memory module. The auxiliary memory module can be activated via the microcontroller, in order to copy a selected data packet into the internal memory. The auxiliary memory module is coupled to the microcontroller of the sensor IC by a serial data interface.
US09446623B2	Egg decorating kit An egg decorating kit formable into an egg decorating assembly includes a plurality of decorating accessories for decorating eggs, a box made of foldable sheet material and an attachment made of sheet material. The box includes a top having a plurality of demarcated sections peripherally arranged about a center point of the top of the box. The top has at least one slit that extends from an outer surface of the top to an inner surface of the top and is surrounded by the demarcated sections. The attachment includes a main body portion and a tab portion coupled to the main body portion. The main body portion has printed indicia located on a front side of the sheet material and printed indicia located on a back side of the sheet material.
US09446622B2	Method and device for producing a surface structure for a metallic press plate, endless belt or embossing roller A method for producing a surface structure for a metallic press plate, endless belt or a cylindrical embossing roller through at least one laser and a device for using the method. In order to provide a cost effective production for the surface structure while using environmentally friendly techniques, it is proposed to use a laser which produces the entire surface structure through partial removal of a surface of a metallic press plate, endless belt or embossing roller to be processed. Thus, the laser is controlled by a provided 3D topography, wherein control of the laser is performed through obtained x, y and z coordinates in order to produce a depth structure, so that high portions and low portions are formed.
US09446621B1	Glove for dry erase surfaces A glove or mitten, worn on the non-writing hand, in which a set of erasers is disposed on the palm and fingers of the glove and one or more writing instruments (e.g., whiteboard markers) are disposed on the back of the hand. Instead of continuously holding onto an eraser while writing, the set of erasers allow the user to easily erase markings on the board. The glove can hold a number, e.g., four, markers on the back the hand. The user can easily retrieve the markers while writing on the dry erase surface.
US09446612B1	Multiple-gripper architecture for multi-sheet-length digital printing Devices and methods to enable a sheet conveyance system within a printing device. According to an apparatus herein, a sheet supply device feeds substrates to a printing system. The apparatus includes an impression cylinder. A first gripper is positioned in a first location on a circumferential wall of the impression cylinder. A second gripper is positioned in a second location on the circumferential wall of the impression cylinder. The second location is angularly spaced apart from the first location around the circumferential wall. A cover selectively covers the second gripper. Responsive to the first gripper gripping an edge of a substrate of a first length supplied from the sheet supply device, the first length being greater than the length of the circumferential arc between the first gripper and the second gripper, the cover provides a smooth curved surface over the second gripper.
US09446611B2	Image forming apparatus capable of reducing downtime of printing when paper stored in paper feeding cassette run out during printing Provided is an image forming apparatus including a plurality of paper feeding cassettes, a paper detecting sensor, a detecting sensor, a paper feeding switching determination part, and a system control part. The paper feeding switching determination part confirms a state change in the paper feeding cassettes, after the elapse of awaiting time until a start of determination of whether or not switching of paper feeding is possible, if it is determined that a document stored in the paper feeding cassettes runs out, based on an operating condition of the apparatus, a change in detection results by the paper feeding detecting sensor, and detection results by the detecting sensor, and determines whether or not the switching of paper feeding is possible. The system control part controls the switching of paper feeding based on the determination results by the paper feeding switching determination part.
US09446610B2	Printing device and method with cutter actuated by displacement of media A printer 1 has a processing unit that processes media; an automatic paper cutter 60 that cuts the media; a conveyance mechanism 63 that conveys media in the direction moving to an exit; a media orientation detection means 65 that detects displacement of the media after conveyance by the conveyance mechanism 63 stops; a limiting unit that restricts movement of the media toward the exit after conveyance by the conveyance mechanism 63 stops; and a media processing device control unit 100 that controls cutting the media by the automatic paper cutter 60 when the media orientation detection means 65 detects displacement of the media.
US09446604B2	White pre-treatment composition A white pre-treatment composition and printing method using such pre-treatment composition are disclosed. Said white pre-treatment composition encompasses a liquid vehicle, a polyvalent metal salt, a latex resin and, at least, 8 wt % of a titanium dioxide particles dispersion. Also disclosed is an ink-set containing said white pre-treatment composition and, at least, an ink composition comprising a liquid vehicle and a colorant.
US09446603B2	System and method for aligning and printing a graphic on an article A flexible manufacturing system for an article of footwear includes a printing system for printing graphics onto the footwear. The flexible manufacturing system also includes a projection system for aligning a projected graphic with a predetermined portion of the article prior to printing the graphic to the article. The graphic can include a masked portion that corresponds to a design element on the article.
US09446598B2	Method and apparatus for controlling light emission of ink cartridge Disclosed is a method and an apparatus for controlling light emission of an ink cartridge. The method includes: an ink cartridge control unit (304), configured to receive a light emitting control instruction from an imaging device main body and identifying the instruction; the ink cartridge control unit (304), configured to control light emission of a light emitting unit (303) of the ink cartridge (10) according to the identified light emitting control instruction and preset control information corresponding to the light emitting control instruction so that the light emitting unit (303) does not emit light at an adjacent position light detection stage but emits light at an facing position light detection stage.
US09446593B2	Liquid ejecting head having a plurality of tributary paths through which liquid flows and liquid ejecting apparatus A flow-path member has a flow path to supply liquid to each head main body having nozzle openings through which liquid is ejected. The flow path of the flow-path member includes a mainstream portion and a plurality of tributary portions which branch off from the mainstream portion. Each of the plurality of tributary portions includes a vertical flow path which is connected, on an outlet port side, to a manifold portion of the head main body. Furthermore, in the vertical flow path, the cross-sectional area changes in the middle thereof. In addition, in the respective vertical flow paths, positions at which the cross-sectional areas change are different from each other.
US09446589B2	Liquid ejecting head and liquid ejecting apparatus A liquid ejecting head includes a nozzle plate including a nozzle opening provided on a first surface of a flow path member with a flow path formed therein, and a protective member including a flexible portion that seals a portion of the flow path provided on the first surface of the flow path member. A position of a portion of the flow path member onto which the nozzle plate is attached and a position of a portion of the flow path member onto which the protective member is attached are different from one another in a discharge direction of a liquid.
US09446578B2	Methods of manufacture and use of customized flexomaster patterns for flexographic printing A method of flexographically printing a uniform pattern on a substrate where the ink deposited on the substrate is deposited in the intended location and not in unintended locations. A flexo-master comprises a pattern formed by a plurality of lines including at least one junction, and printing the pattern including the at least one junction in ink on a substrate forming a printed pattern, wherein the printed junction has a different shape than the at least one junction on the flexo-master. In addition to the junction formation, a discontinuous line on the flexo-master may be used to print a continuous line, a single line may be used to print two lines, and two or more lines may be used to print a single line. The flexo-master pattern lines may additionally have a fill pattern comprising various geometries that are used to uniformly print the pattern on the substrate.
US09446573B2	Lubrication box for a wet shaving implement According to one aspect of the present invention, a lubrication box includes a first portion, a shaving aid material, and a second portion. The first portion of the lubrication box has a skin-engaging surface and at least one sidewall that, together, form a cavity. The skin-engaging surface includes at least two holes therethrough. The shaving aid material is pre-formed in a pre-determined shape, placed in the first portion of the lubrication box, and then compressed. The second portion of the lubrication box is attached to the first portion such that the cavity is substantially closed. A gap exists between in the cavity between the shaving aid and the second portion of the lubrication box to permit the shaving aid material to expand during normal use.
US09446569B2	Method for manufacturing display device A window bonding apparatus is provided. The window bonding apparatus includes a resilient display panel supporter supporting a flexible display panel thereon, a holding member supporting and squeezing inwardly opposed ends of the display panel supporter so as to attain a desired degree of curvature, a first jig disposed under the display panel supporter and having a rigid first face with which the bottom face of the display panel supporter comes into contact when pressed from above, and a second jig disposed above the display panel supporter and having a second face to which the window is releaseably attached, the second jig being movable toward the display panel, wherein the second jig is moved to the first jig to attach the window to the display panel in a manner which progressively increases contact area between the window and the display panel.
US09446565B2	Steel armor wire coatings A wire includes a ferrous core. The ferrous core can be coated. The coatings can include nickel, molybdenum, zinc and Fe. A process of forming a wire can include placing a metal strip alongside a ferrous wire core, bending the strip around the core, and seam welding the strip to form a metal tube around the core. The process of forming a wire can include applying a metal layer to a ferrous metal rod to form a plated rod, placing a metal strip alongside the rod, bending the strip around the rod, and seam welding the strip to form a metal tube around the rod. The process of forming a wire can include coating a ferrous wire core with a layer of nickel, molybdenum or a nickel alloy that circumferentially surrounds the ferrous wire core.
US09446563B2	Liquid repelling coating A backside coated fabric includes a fabric substrate having a front side (face) and a back side. A water permeable spacer layer is applied to the back side of the fabric substrate. The water permeable spacer layer allows penetration of water into its matrix when hydrostatic water pressure is applied to the face of the fabric substrate. The water permeable spacer layer provides a smooth coating surface onto which subsequent water impermeable barrier layers can be applied creating a physical separating layer between the fabric substrate and the water impermeable barrier layer. A water impermeable barrier layer is disposed over the water permeable spacer layer to provide an impermeable water barrier layer that does not allow penetration of water through the coated fabric when hydrostatic water pressure is applied to the face of the fabric construction.
US09446558B2	Three-dimensional printing apparatus and printing head module A three-dimensional (3-D) printing apparatus including a base, a printing head module and a control unit is provided. The base has a carrying surface. The printing head module is disposed above the base. The printing head module includes a body and a discharge outlet switching component. The body includes a material supplying channel. The discharge outlet switching component is movably disposed at the body. The discharge outlet switching component includes a plurality of discharge outlets. Diameters of the discharge outlets are different from each other. The control unit is configured to choose one of the discharge outlets according to the diameters and connect the chosen discharge outlet to the body, such that the material supplying channel is connected to the corresponding discharge outlet.
US09446550B2	Apparatus and method for producing plastic containers An apparatus for producing plastic containers includes: a forming machine for producing plastic preforms; a blow-moulding machine for blowing the preforms to obtain containers, provided with a blow-moulding carousel having a plurality of blow-moulding moulds that expand the preforms to obtain the containers; a thermal conditioning station interposed between the forming machine and the blow-moulding machine; a storage station, configured for receiving and containing preforms; a supplying system for feeding the thermal conditioning station with preforms contained in the storage station.
US09446547B2	Nanofiber filtering material for disposable/reusable respirators Embodiments relate generally to methods of manufacture of a filtration media, such as a personal protection equipment mask or respirator, which may incorporate a FORCESPINNING™ process to form nanofibers. Some embodiments may comprise FORCESPINNING™ material onto a convex mold, which may, for example, be in the shape of a human face. Other embodiments may comprise FORCESPINNING™ material onto an inner and/or outer shell of a personal protective equipment mask, such as a flat fold mask. In an embodiment, the forcespun nanofibers may be functionalized, and therefore may, for example, be operable to capture one or more gases.
US09446541B2	Method of protecting the end of a multi-tendon cable The method is for protecting the end of a cable made of a plurality of parallel tendons (10) anchored using a block (15) having a front side, a rear side and channels (16) extending between the front and rear sides. Each tendon of the cable is held in a respective channel of the anchor block with a blocking member (19). The method comprises performing a first phase of injecting protective material (100) into at least some of the channels of the anchor block. A chamber (30) is formed on at least one side of the anchor block (15) so as to contain portions of the plurality of tendons. A second phase of injecting protective material (200) into the chamber (30) is then performed.
US09446540B2	Hybrid composite utilizing injection-expansion molding A vehicular instrument panel including a substrate having a first plurality of chopped carbon fibers within a first nylon resin and an expanded reinforcement coupled to the substrate having a second plurality of chopped carbon fibers within a second nylon resin. The first plurality of chopped carbon fibers and the first plurality of glass fibers in the substrate are segregated such that the carbon fibers and the glass fibers are each substantially concentrated within respective driver-side and passenger-side portions of the substrate. An expanded, structural duct has a second plurality of chopped glass fibers within a third nylon resin. The duct, reinforcement and substrate are coupled to form a hollow tube.
US09446537B1	Methods and apparatuses for cutting of thin film solar cells Methods and apparatuses for cutting thin film solar cells are provided. According to various implementations, the methods involve cutting a substrate having thin film solar cell materials deposited thereon by inducing a tear along the cutting line. Simultaneously with the tearing, the torn edges may be plastically deformed to produce a desired torn edge cross-sectional profile. Such a fracture may be induced by clamping regions of the substrate while simultaneously displacing the clamped regions relative to each other through the thickness of the substrate as the substrate is fed through the clamps providing the clamping. Apparatuses for cutting are also provided. According to various implementations, the apparatus may have cutter rollers and support rollers configured with an adjustable radial overlap.
US09446533B2	Power tool safety mechanisms A sensing mechanism (12) for detecting user contact with an active portion (26) of the power tool (10) is provided. In addition, a safety mechanism (14) for preventing prolonged user contact with the active portion (26) of a power tool (10) is provided. The safety mechanism (14) is configured to actuate upon receipt of a signal from the sensing mechanism (12). According to a first aspect, the safety mechanism (14) is arranged to rapidly displace the active portion (26) away from a user extremity. Alternatively, according to a second aspect, the safety mechanism (14) is arranged to rapidly urge an extremity of the user away from the active portion (26) of the power tool (10).
US09446528B1	Ring with cutting blade A ring includes a ring body having a shoulder, a neck extending from the shoulder, and a cap extending from the neck and spaced apart from the shoulder, thereby defining a gap between the cap and the shoulder. A blade is mounted in both the cap and neck, and the blade has a curved edge extending from the head to the shoulder and into the gap.
US09446527B1	Pull-type cutters One feature pertains to cutters that include a top lever having a first end that includes a first handle, and a bottom lever having a first end that includes a second handle. The bottom lever includes a bottom edge. The cutters also include a cutting lever having a top edge, a first member rotatably coupling the cutting lever to the bottom lever, and a second member coupling the top lever to the cutting lever. The top lever may move the second member when the first handle is moved relative to the second handle. Moving the second member causes the cutting lever to rotate about the first member to move the top edge toward or away from the bottom edge. The top edge and the bottom edge extend from the first member in a substantially same direction as the first and second handles.
US09446524B2	Wire clamp with piezoelectric actuator and method and apparatus for applying a preload force to the piezoelectric actuator A wire clamp includes a clamp body; a pair of arms coupled to the clamp body; and a piezoelectric actuator having a longitudinal axis extending between a first end and a second end, the actuator being coupled to the pair of arms at the first end and to the clamp body at the second end. The second end of the actuator is coupled to the clamp body by a preload mechanism for applying a preload force along the longitudinal axis, and the preload mechanism comprises at least one wedge having an inclined surface which is slidable over a mating inclined surface.
US09446523B2	Programming of a robotic arm using a motion capture system An example method includes receiving position data indicative of position of a demonstration tool. Based on the received position data, the method further includes determining a motion path of the demonstration tool, wherein the motion path comprises a sequence of positions of the demonstration tool. The method additionally includes determining a replication control path for a robotic device, where the replication control path includes one or more robot movements that cause the robotic device to move a robot tool through a motion path that corresponds to the motion path of the demonstration tool. The method also includes providing for display of a visual simulation of the one or more robot movements within the replication control path.
US09446521B2	Obstacle following sensor scheme for a mobile robot A robot obstacle detection system including a robot housing which navigates with respect to a surface and a sensor subsystem aimed at the surface for detecting the surface. The sensor subsystem includes an emitter which emits a signal having a field of emission and a photon detector having a field of view which intersects the field of emission at a region. The subsystem detects the presence of an object proximate the mobile robot and determines a value of a signal corresponding to the object. It compares the value to a predetermined value, moves the mobile robot in response to the comparison, and updates the predetermined value upon the occurrence of an event.
US09446519B2	Remote testing method and system In one example, a method is provided for a computing device to facilitate testing of an electronic apparatus. The method includes receiving a request from an apparatus coupled to a network to which the computing device is also coupled. The method further includes retrieving a command for a robot controlled by the computing device from the request, and configuring the robot to physically interface with the electronic apparatus to perform one or more tests according to the command.
US09446516B2	Method and means for providing and/or controlling a manipulator process A method for designating and/or controlling a manipulator process for a manipulator configuration having at least one manipulator, in particular, an industrial robot, wherein the manipulator process includes a given oriented manipulator path for the manipulator configuration. The method includes designating or executing at least one action by the manipulator configuration, in particular, differently, in response to a reverse movement running counter to the oriented manipulator path, and/or a return movement running in the same direction as the oriented manipulator path.
US09446515B1	Apparatus and methods for controlling attention of a robot Apparatus and methods for controlling attention and training of autonomous robotic devices. In one approach, attention of the robot may be manipulated by use of a spot-light device illuminating a portion of the aircraft undergoing inspection in order to indicate to inspection robot target areas requiring more detailed inspection. The robot guidance may be aided by way of an additional signal transmitted by the agent to the robot indicating that the object has been illuminated and attention switch may be required. Responsive to receiving the additional signal, the robot may initiate a search for the signal reflected by the illuminated area requiring its attention. Responsive to detecting the illuminated object and receipt of the additional signal, the robot may develop an association between the two events and the inspection task. The light guided attention system may influence the robot learning for subsequent actions.
US09446509B2	Mobile tool cart and storage system including tool storage devices A storage system includes a mobile tool cart having multiple shelves, each of which may be provided with tool storage devices, such as interconnected arrays of tubes that are sized to receive individual tools or pieces of equipment. The tubes in the tool storage devices may include tubes of varying diameter and/or length so as to accommodate different types of equipment needed at a worksite. The arrays of tubes are arranged on the shelves of a tool cart in any desirable configuration, and additional tool storage elements such as socket holders may also be placed on the shelves. The storage system also includes a storage housing configured to cover the tool cart and prevent unauthorized access to the equipment and tools during periods of non-use.
US09446506B2	Tool having dual flex heads The present invention relates to a tool having dual flex heads. The tool may have a flex head having a ratchet head and a flex head having a bit driver head. The flex heads may include a locking mechanism.
US09446505B2	Strap wrench A strap wrench is used to drive a cylindrical object and contains: a handle including two recesses and a longitudinal slot; a strap including a first end portion and a second end portion which are inserted into the two recesses; a guiding rod longitudinally inserted into the handle; a supporting block rotatably connected with a first segment and located inside the strap; a movable member disposed on the guiding rod and moving between a first position and a second position, the movable member joining with the strap; a push switch slidably fixed in the longitudinal slot and rotatably connected with the movable member; and a spring for pushing the movable member to move toward the second position. Thereby, the movable member is driven by the engaging block to move between the first position and the second position so as to operate the strap wrench easily.
US09446504B2	Polycrystalline compacts including interbonded nanoparticles, cutting elements and earth-boring tools including such polycrystalline compacts, and related methods Polycrystalline compacts include non-catalytic, non-carbide-forming particles in interstitial spaces between interbonded grains of hard material in a polycrystalline hard material. Cutting elements and earth-boring tools include such polycrystalline compacts. Methods of forming polycrystalline compacts include forming a polycrystalline material including a hard material and a plurality of particles comprising a non-catalytic, non-carbide-forming material. Methods of forming cutting elements include infiltrating interstitial spaces between interbonded grains of hard material in a polycrystalline material with a plurality of non-catalytic, non-carbide-forming particles.
US09446502B2	Shaped, fractured abrasive particle, abrasive article using same and method of making Precursor alpha alumina abrasive particles in a mold are subjected to a drying process that cracks or fractures at least a majority of the precursor abrasive particles into at least two pieces thereby producing abrasive shards having a smaller size than the mold cavity from which they were made. The smaller abrasive shards, once formed, could be reassembled like jigsaw puzzle pieces to reproduce the original cavity shape of the mold from which they were made. The cracking or fracturing of the precursor abrasive particles is believed to occur by ensuring that the surface tension of the abrasive dispersion to the walls of the mold is greater than the internal attractive forces of the abrasive dispersion as the abrasive dispersion is dried within the mold cavity.
US09446498B1	Chemical mechanical polishing pad with window A chemical mechanical polishing pad is provided having a polishing layer; an endpoint detection window; subpad; and, a stack adhesive; wherein the subpad includes plurality of apertures in optical communication with the endpoint detection window; and, wherein the polishing surface of the polishing layer is adapted for polishing of a substrate.
US09446497B2	Broad spectrum, endpoint detection monophase olefin copolymer window with specific composition in multilayer chemical mechanical polishing pad A multilayer chemical mechanical polishing pad is provided, having: a polishing layer having a polishing surface, a counterbore opening, a polishing layer interfacial region parallel to the polishing surface; a porous subpad layer having a bottom surface and a porous subpad layer interfacial region parallel to the bottom surface; and, a broad spectrum, endpoint detection window block comprising, comprises an olefin copolymer; wherein the window block exhibits a uniform chemical composition across its thickness; wherein the polishing layer interfacial region and the porous subpad layer interfacial region form a coextensive region; wherein the multilayer chemical mechanical polishing pad has a through opening that extends from the polishing surface to the bottom surface of the porous subpad layer; wherein the counterbore opening opens on the polishing surface, enlarges the through opening and forms a ledge; and, wherein the window block is disposed within the counterbore opening.
US09446496B2	Abrasive belt polishing finisher The invention discloses an abrasive belt polishing finisher in the field of mechanical technology, which addresses inconvenient operation of the existing polishing finishers. The abrasive belt polishing finisher includes a motor and a connection support. The central section of the connection support is fixedly connected with the output shaft of the motor. Several self-rotable connection support finishing wheels are provided around the connection support. The curve surface of the rim of each of the support finishing wheels has a different curvature. Each connection support finishing wheel is distributed on the same circle centered on the output shaft of the motor. The connection support is driven by the motor into rotation to press and position one of the connection support finishing wheels against the back of the abrasive belt in the polishing finisher. The abrasive belt polishing finisher could satisfy continuous polishing treatment for different curved surfaces.
US09446494B2	Device for grinding, precision-grinding and/or polishing of workpieces in optical quality, particularly of spherical lens surfaces in precision optics A device for grinding and/or polishing of, in particular, precision-optical spherical lens surfaces has a machine frame, a tool spindle for rotational drive of a tool about a tool axis of rotation and a workpiece spindle for rotational drive of a workpiece about a workpiece axis of rotation. The tool spindle and workpiece spindle are capable of axial relative adjustment in first and second directions extending perpendicularly to one another and in addition pivotable about a pivot axis in a pivot plane relative to one another. Equipment for cross-grinding adjustment is provided, which has an adjusting mechanism to position the workpiece spindle in a third direction extending perpendicularly to the first and second directions. A clamping mechanism activatable independently of the adjusting mechanism serves the purpose of fixing the workpiece spindle, once positioned, with respect to the machine frame.
US09446491B2	Method for trimming a pre-coated ophthalmic eyeglass lens Method of shaping an ophthalmic eyeglass lens presenting two main optical working faces and including firstly a substrate made of a first material and presenting two main faces corresponding to the two main faces of the lens, and secondly at least one coating film made of a material distinct from that of the substrate, the coating film being previously secured on at least one of the main faces of the substrate, includes: cutting the lens by machining with a first tool over at least the thickness of the previously secured coating film, to define internally a working central portion of the coating film that presents a reduced outline; trimming the edge face of the substrate along the desired outline by machining with a second distinct tool, without machining the working central portion; and finishing the edge face of the substrate without machining the working central portion.
US09446486B2	Internal heat exchanger for a motor vehicle air-conditioning system A heat exchanger is provided for a motor vehicle air-conditioning system with an inner tube and with an outer tube, which at least in regions encloses the inner tube in the region of a line portion subject to forming an intermediate space in tube longitudinal direction through which a heat exchanger medium can flow. The intermediate space at least in portions is subdivided into at least three flow channels with at least three webs running in tube longitudinal direction, which open into a distribution or manifold space formed through radial expansion of the outer tube, in which the webs compared with the line portion have a smaller extension in radial direction.
US09446478B2	Device for applying laser radiation and device for reproducing a linear light distribution A device for applying laser radiation to an at least partially reflective or transparent region or a workpiece disposed in a working area, with a laser light source for generating the laser radiation and optics for influencing the laser radiation, such that the radiation is transferred into the working area, wherein the optics comprise at least one mirror that can reflect a part of the laser radiation reflected in the working area or a part of the laser radiation having passed through the working area, such that said part of the laser radiation is at least partially fed hack into the working area.
US09446477B2	Bonding head A bonding head 6 is provided with a tool base 8 in a housing 6A and a laser for transmitting laser beam L is configured such that the laser beam L transmitted through this tool base 8 can heat an electronic component 3 and bond the same to a substrate 2. A surface of a heat-radiating member 15 is provided in contact with a surface of the tool base 8 on which the laser beam L impinges. This heat-radiating member 15 has a light transmittance for transmitting the laser beam L and also has a thermal conductivity higher than the thermal conductivity of the tool base 8. The tool base 8 is heated during bonding treatment, but heat transmitted to the tool base 8 rapidly escapes to the heat-radiating member 15 having a higher thermal conductivity.
US09446476B2	Backing arrangement for use in friction stir welding Backing arrangement for supporting a welded seam extending on a curved path which is formed between two curved work pieces by friction stir welding with a welding tool separate from the backing arrangement, which backing arrangement comprises a backing body which is intended to bear upon the work pieces opposite said welding tool to assume at least a part of the compression force that is exerted by the welding tool against the work pieces to keep the material plasticized during the welding operation in the area of the welded seam The backing body is equipped with a shoulder which exhibits a bottom surface turned outward, via which the backing body is equipped to bear on the work pieces. A driving mechanism is situated to rotate and/or oscillate the shoulder so that the bottom surface of the shoulder can thereby be made to carry out a rotating and/or oscillating motion against the work pieces for creating fictional heat in them.
US09446472B2	System and method for integrated controller The invention described herein generally pertains to a system and method related to integrating cutting or marking operation parameters and motion parameters. A controller is provided that manages both process related control and motion related controls rather than having separate controllers with respective connectivity. The controller provides integrated process related control and motion related control which directly controls a cutting or marking operation with improved dynamics while minimizing connectivity and data communications.
US09446471B2	Systems and methods for communicating with welding equipment Systems and methods for reading data from and/or writing data to various components of a welding installation are provided. The data is exchanged between devices using near field communication.
US09446470B2	Enhanced magnetically impelled arc butt wielding (MIAB) technology A magnetically impelled arc butt (MIAB) welding device heats facing ends of a pair of wellbore tubulars and a force application device compressively engages the facing ends to form a welded joint. The device may be positioned on the rig floor. The MIAB welding device may include a device configured to hold facing ends of the two wellbore tubulars at a specified distance away from one another, a high frequency arc ignition device configured to generate an arc between the facing ends and to revolve the arc around the circumference of the facing ends, and a magnetic field generator configured to superimpose a magnetic field at the facing ends. The MIAB welding device may be configured to melt at least a surface of the facing ends.
US09446469B2	Device for axially holding an element of elongate shape and for setting it in rotation around its axis An installation for welding top plugs on to nuclear fuel rods comprising a device for axially holding the rod and setting it in rotation and a weld chamber, where the device comprises a gripper and structure to close the gripper on the rod, where the structure comprise a pusher to apply an axial force on to the gripper, a linear actuator of axis parallel to the lengthways axis of the device, a yoke translationally secured to the pusher, and able to rotate freely around a fixed axis orthogonal to the lengthways axis which is not secant with the latter, where the yoke is connected and able to pivot relative to the linear actuator around a fixed axis parallel to the orthogonal axis such that the linear actuator causes the yoke to rotate around the first orthogonal axis and causes the pusher to slide, closing the gripper on the rod.
US09446466B2	Wire electrical discharge machine for performing machining using linear and rotational operations, speed and sectional transitions A wire electrical discharge machine is provided with a rotating shaft for rotating a workpiece. In wire electrical discharge machining according to a machining program, a current average rotation radius at a current workpiece machining point is calculated for each predetermined period, based on average rotation radii at respective end points of a block to be executed and a directly preceding block and an amount of movement of the rotating shaft. Based on the calculated current average rotation radius, control is performed such that the speed of movement of the wire electrode relative to the workpiece machining point agrees with a command speed acquired from a machining power supply.
US09446465B2	Wire electric-discharge machining apparatus A control unit controls an on/off operation of a switching unit such that a first DC pulse voltage is applied across an electrode gap from a pulse-voltage generation unit adjusted to a first impedance, and when a detection unit detects a preliminary discharge, a second DC pulse voltage is applied across the electrode gap from the pulse-voltage generation unit adjusted to a second impedance, which is lower than the first impedance, so as to generate a main discharge in the electrode gap, and during an idle time since the main discharge is completed until the next preliminary discharge is started, a third DC pulse voltage that is equal to or higher than a discharge arc voltage is applied across the electrode gap from the pulse-voltage generation unit adjusted to a third impedance, which is higher than the first impedance.
US09446463B2	Tap holder Provided is a tap holder configured so that compression-side elastic characteristics and tension-side elastic characteristics are different from each other with utilization of an elastic member for absorbing synchronization error in rotation and feeding of a spindle of a machine tool. The tap holder includes a chuck 20 for holding a tap P, and a holder body 10 for holding the chuck 20 so that the chuck 20 is movable along a rotational axis X and rotatable in synchronism with the chuck 20. The tap holder further includes elastically deforming members 31, 32, 33 provided in a tension direction and a compression direction, respectively and deformable between the chuck 20 and the holder body 10 when a tension force or a compression force is applied to the tap P along the direction of the rotational axis X, and a deformation reducing mechanism 29 for the elastically deforming members 31, 32, 33 such that a deformation amount along the rotational axis X generated in at least one elastically deforming member 31, 32 of the elastically deforming members 31, 32, 33 disposed respectively in the tension direction and the compression direction is smaller than an amount of displacement of the chuck 20 along the rotational axis X.
US09446462B2	Material cutter clamping collet A clamping assembly is disclosed that includes a tapered collar extending radially inward towards an axis. A clamping sleeve is movable along the axis relative to the tapered collar. The clamping sleeve includes flexible arms. An actuator is coupled to the clamping sleeve and is configured to move the clamping sleeve along the axis between extended and retracted positions. A collet is supported relative to the sleeve. The collet includes a body having an axially extending opening configured to receive the material and circumferential fingers arranged about the opening. The clamping sleeve forces the fingers radially inward with the clamping sleeve in the extended position to clamp and hold the material. The biasing member urges the fingers radially outward with the clamping sleeve in the retracted position. Replaceable inserts can also be secured to each finger facing the opening.
US09446461B2	Cutting tool for seamless gutter machine A cutter for cutting a formed gutter discharged from a seamless gutter machine. The cutter may be positioned to cut a back wall of a formed gutter below a front upper edge of a front wall of the gutter. In turn, a gutter may be mounted to a building (e.g., a fascia board thereof) to achieve additional lift, thereby providing increased pitch over a given length of gutter while maintaining overlap between a gutter apron and a back upper edge of the back wall of the formed gutter.
US09446455B2	Drilling apparatus A drilling apparatus for drilling from inside a conduit having at least one service entrance is described. The drilling apparatus comprises a robot; an elongated flexible appliance having a first end and a second end, the elongated flexible appliance connected to the robot; a rotatable drill head connected to the second end of the elongated flexible appliance; the elongated flexible appliance driven by the robot to extend the rotatable drill head inside the service entrance by at least 8 cm and to retract the rotatable drill head out of the at least one service entrance. The apparatus further comprises means to bend the elongated flexible appliance to orient the drill head connected thereto perpendicular to a longitudinal axis of the conduit.
US09446453B2	Drive center with guard A drive center constituting a machine tool accessory being used on a lathe for holding workpieces that are mounted between the headstock and the tailstock (between centers). The drive center includes a head having an adjustable spring-loaded center point and a number of removable, adjustable spurs that are capable of penetrating a workpiece sufficiently to provide torque for the turning process. The head is attached to a shank with a standard taper to fit the spindle of a lathe. A cylindrical guard is supported coaxially by the external surface of the head so that the guard radially encircles the head and the spurs but is able to slide axially and rotationally with respect to the head. A spring causes the guard to extend axially beyond the spurs except when pushed back by the workpiece.
US09446451B2	Machine tool to which rotary tool unit can be attached A machine tool 1 includes a turret (4, 104) to which a tool unit 2 is adapted to be radially mounted, a cylindrical turret pivoting driving shaft (5, 105) for transmission of pivoting driving force to the turret (4, 104), a rotary tool driving shaft (8, 108) adapted to be rotated with respect to an indexing axis for transmission of rotation driving force to a tool (7, 107) of a rotary tool unit (2b, 102b) mounted on the turret (4, 104), and a unit pivoting driving shaft (12, 112) adapted to be rotated with respect to the indexing axis independently of the rotary tool driving shaft (8, 108) for transmission of pivoting driving force to the rotary tool unit (2b, 102b) mounted on the turret (4, 104) to change the direction of the rotation axis AX2 of the tool (7, 107). The rotary tool driving shaft and the unit pivoting driving shaft are coaxially arranged inside the turret pivoting driving shaft.
US09446437B1	Methods of cleaning and protecting surfaces and isolating volumes The invention provides a method of cleaning a surface by providing a cleaning composition having a prevulcanized natural rubber latex, at least one detergent additive and aqueous ammonia and other bases to provide a pH of the cleaning composition of at least 8, applying the cleaning composition to the surface, allowing the composition to form an elastic rubber film/membrane and removing the elastic rubber film/membrane from the surface with the unwanted matter attached to the membrane.
US09446436B2	Continuous or semi-continuous biomass wash system for hydrothermal hydrocatalytic conversion A selective removal of metal and its anion species that are detrimental to subsequent hydrothermal hydrocatalytic conversion from the biomass feed in a continuous or semi-continuous manner prior to carrying out catalytic hydrogenation/hydrogenolysis/hydrodeoxygenation of the biomass that does not reduce the effectiveness of the hydrothermal hydrocatalytic treatment while minimizing the amount of water used in the process is provided.
US09446431B2	Hydrophilic coatings and methods for coating medical devices with hydrophilic coatings Medical device surfaces, for example a plastic catheter or metal guide wire, are disclosed with a lubricating coating made from Brasenia schreberi polysaccharide mucilage. The coated device surfaces may be prepared with a variety of techniques offering improved alternatives to conventional coatings.
US09446430B2	Bisphenol A and aromatic glycidyl ether-free coatings Disclosed are Bisphenol A (BPA), Bisphenol F, Bisphenol A diglycidyl ether (BADGE), and Bisphenol F diglycidyl ether (BFDGE)-free coating compositions for metal substrates including an under-coat composition containing a polyester (co)polymer, and an under-coat cross-linker; and an over-coat composition containing a poly(vinyl chloride) (co)polymer dispersed in a substantially nonaqueous carrier liquid, an over-coat cross-linker, and a functional (meth)acrylic (co)polymer. Also provided is a method of coating a metal substrate using the BPA, BPF, BADGE and BFDGE-free coating system to produce a hardened protective coating useful in fabricating metal storage containers. The coated substrate is particularly useful in fabricating multi-part foodstuffs storage containers with “easy-open” end closures.
US09446426B2	Device and method for painting curved outer surfaces of an aircraft A device for painting a curved outer surface of an aircraft includes a paint applicator having a plurality of spray painting heads each assigned to one of a plurality of different base color supply units containing one of polyurethane aircraft paint and ink. The device further includes a spatially adjustable positioning device configured to move the paint applicator relative to the curved outer surface and at least one sensor device configured to determine a three-dimensional geometry of the curved outer surface. The device also includes a control unit configured to coordinate a movement of the positioning device with a paint output of the paint applicator, wherein the control unit is configured to alternately activate each of the plurality of spray painting heads so as to produce a picture motif so as to derive a two-dimensional driving geometry based on the three-dimensional geometry.
US09446424B2	Packaging, dispensing and use of contents having a liquid to pasty consistency A device for packaging, dispensing and using fluid contents having a liquid to pasty consistency, includes: a container having, at its front portion, a downstream opening, an element for conveying the contents including an upstream opening, an axially extended passage and a front downstream opening for dispensing the contents, the passage being elastically deformable and capable of being in an idle state having a maximum interior volume or in a compressed state having a smaller interior volume, an upstream valve element, a downstream valve element, a front wall, wherein is situated the front downstream dispenser opening, a movable annular actuating element associated with the passage of the conveying element and consisting of an elastically deformable annular side wall, which limits the passage laterally and externally. The side wall is positioned on the outside and includes an outer side wall of the device, which is at least partially accessible for actuating.
US09446423B2	Air gun with sucking function An air gun with sucking function comprises a gun body, an air intake control set and an airflow switching and controlling element. The air gun with sucking function of the present invention employs the airflow switching and controlling element disposed inside the gun tube of the gun body for switching an airflow flowing direction and converting an airflow ejection into a sucking airflow in order to meet various work requirements by switching to different functions. When it is switched for sucking airflow for cleaning, dust can be prevented from flying around and therefore is healthier for breathing.
US09446422B2	Adhesive dispensing module and method of spraying a plurality of droplets of a liquid adhesive An adhesive dispensing module and method of spraying a plurality of droplets of a liquid adhesive includes a dispenser assembly and a nozzle. The nozzle includes a nozzle body, a dispersion baffle, and at least one channel. The nozzle body includes a nozzle outlet for discharging a liquid adhesive and at least partially defines a gas inlet, a gas outlet, and a gas passage extending therebetween. The dispersion baffle is positioned within the gas passage to define a dispersion chamber and a consolidation chamber. The at least one channel extends through the dispersion baffle to fluidly connect the dispersion chamber to the consolidation chamber to restrict the pressurized gas received within the dispersion chamber and distribute the pressurized gas into the consolidation chamber according to a predetermined flow distribution. Thereby, the pressurized gas sprays a plurality of droplets of the liquid adhesive according to a predetermined pattern.
US09446418B2	Robotic arm An analytical laboratory system and method for processing samples is disclosed. A sample container is transported from an input area to a distribution area by a gripper comprising a means for inspecting a tube. An image is captured of the sample container. The image is analyzed to determine a sample container identification. A liquid level of the sample in the sample container is determined. A scheduling system determines a priority for processing the sample container based on the sample container identification. The sample container is transported from the distribution area to a subsequent processing module by the gripper.
US09446411B2	Sample assembly for a measurement device A sample presentation apparatus comprises a round support movable in an optical assembly and having a flange region and an elevated gear shaped region having indexing gear cogs at intermediate radius locations of the support; a sample carrier slide holder removably supported on and movable with the support, the slide holder having at least one arm extending radially from a central hub of the sample carrier slide holder and being aligned between a first pair of indexing gear cogs; and at least one sample carrier slide removably supported on the support and aligned by the first pair of indexing gear cogs. In another embodiment of the invention, a self-aligning movable platform and support apparatus in an optical assembly comprises coarse and fine alignment mechanisms.
US09446403B2	Micro-channel chip A micro-channel chip comprises two gas control channels, a liquid inlet channel, a liquid outlet channel, a piston channel, and a micro pump including two micro-valves and a plurality of micro-channels. One of the gas control channels communicates with one end of the piston channel and communicates with the two micro-valves and the liquid inlet channel respectively via the micro-channels. The other one of the gas control channels communicates with the two micro-valves and the liquid outlet channel respectively via the micro-channels. The other end of the piston channel communicates with one of the micro-valves via the micro-channels.
US09446402B2	Specimen supplying tool and specimen analysing instrument using the same A specimen supplying tool in which structure is simple, and a liquid specimen and air bubbles do not remain within a through-bore for introduction of a specimen, is provided. The specimen supplying tool includes a substrate 11 and a through-bore 13 provided in the substrate 11. One opening of the through-bore 13 is a specimen inflow port, and the other opening of the through-bore 13 is a specimen outflow port. The specimen supplying tool further includes a projection portion 14 projecting from a part p of a marginal part of the specimen outflow port. A liquid specimen is introduced from the specimen inflow port to the through-bore 13. When the introduced liquid specimen is discharged from the specimen outflow port, and supplied to a specimen analyzing instrument, the liquid specimen is drawn to the projection portion 14, led by the projection portion 14, and supplied to the specimen analyzing instrument.
US09446401B2	Container for the aseptic transfer of a biopharmaceutical product A container for ensuring the transport and the aseptic transfer of a biopharmaceutical product from or to a closed chamber provided with a leaktight joining device, includes: an annular flange delimiting an opening, a removable cover, built-in elements for locking/unlocking the removable cover and a peripheral envelope. The built-in locking/unlocking elements include a built-in functional locking/unlocking arrangement formed by a through-housing formed in the annular flange and a blind housing formed in the removable cover, and by a pin at an inner radial position and a pin at an outer radial position. The container is capable of being in an initial locking position, in an intermediate unlocking position and in a final locking position owing to the displacements of the pin at an inner radial position and the pin at an outer radial position in the blind hole of the removable cover and in the through-housing of the annular flange.
US09446398B2	Stripping vessel for removing hydrocarbons entrained in catalyst particles A stripping vessel for removing hydrocarbons from a catalyst and a process for removing hydrocarbons from a catalyst. In an FCC unit, the stripping vessel includes first and second stripping sections. The first stripping section includes at least one grid having a plurality of interesting members and openings therebetween. The second stripping section includes structured packing such as a plurality of ribbons. The one or more grids are spaced from the structured packing, and from each other, so as to minimize the accumulation of catalyst within the stripping vessel, preferably between about 0.91 m (3 ft) to about 1.5 m (5 ft).
US09446397B2	Method for isolation of nanomaterials Methods for isolation and/or purification of nanomaterials, such as nanowires, are provided. The disclosed methods include isolation of nanomaterials via a filter press and are amenable to large-scale production of nanomaterials. Related methods for isolation, purification and/or doping of nanomaterials are also provided.
US09446396B2	Support for catalyst of exothermic processes and catalyst prepared thereon The present invention relates to petrochemistry and gas chemistry, and discloses a support for catalysis of exothermic processes, particularly the Fischer-Tropsch process, methanol synthesis, hydrogenation and purification of exhaust gases. The support comprises metallic aluminum in the form of a mixture of dispersed powders of flaky and spherical aluminum and the support is in the form of pellets, preferably cylinders, tablets, balls, obtained by extrusion, pelletization, tabletting, rounding or liquid molding. The catalyst prepared on the support comprises an active metal selected from the group consisting of Co, Fe, Ni, Ru, Rh, Pt, Pd, Cu and mixtures thereof.
US09446395B2	Low temperature catalyst/hydrocarbon trap A low-temperature catalyst is provided for reducing cold-start hydrocarbon emissions. The catalyst comprises a platinum group metal impregnated onto an oxygen storage material. The catalyst may be used alone or may be included in a hydrocarbon trap containing a hydrocarbon adsorption material therein. The catalyst/hydrocarbon trap is positioned in the exhaust system of a vehicle downstream from a close-coupled catalyst such that the exhaust temperature at the catalyst location does not exceed 850° C. during normal vehicle operation and when combined with a hydrocarbon adsorption material in a trap, the exhaust temperature does not exceed 700° C.
US09446394B2	Z-selective ring-closing metathesis reactions The present invention relates generally to olefin metathesis. In some embodiments, the present invention provides methods for Z-selective ring-closing metathesis.
US09446393B2	Transition metal complexes for enantioselective catalysis of carbon-carbon, carbon-heteroatom, and carbon-hydrogen bond forming reactions In some embodiments, the present disclosure pertains to a compound, comprising a transition metal complex having the formula Φ-[M(x,y)-L1(w,v)-L2(t,u)-L3]p+An−mZ−p_m. In an embodiment of the present disclosure Φ may be A. In another embodiment Φ may be Δ. In some embodiments of the present disclosure, M is a transition metal. In a related embodiment, p is an integer corresponding to the oxidation state of M. In some embodiments of the present disclosure, each of x, y, w, v, t, and u independently comprise R. In other embodiments, each of x, y, w, v, t, and u independently comprise S. In an embodiment of the present disclosure, each of L1, L2, and L3 independently is a ligand comprising a substituted diamine. In some embodiments, An″ comprises a lipophilic anion, where m is from 1 to 3, and where Z− comprises an optional second anion.
US09446392B2	Method for preparing proton-conducting particles capable of catalyzing the reduction of oxygen or the oxidation of hydrogen by grafting proton-conducting polymers to the surface of the particles The invention relates to a method for preparing particles comprising a material capable of catalyzing the reduction of oxygen or the oxidation of hydrogen, said particles being functionalized by polymers comprising at least one repeating unit bearing at least one proton-conducting group, and said particles being covalently bonded to a carbon material, said method comprising: a step a) of contacting particles, comprising a material capable of catalyzing the reduction of oxygen or the oxidation of hydrogen, with a polymer comprising at least one repeating unit bearing at least one proton-conducting group and comprising at least one portion corresponding to an organic radical of a compound that is an initiator for ATRP polymerization, said radical comprising at least one group capable of being grafted onto the surface of said particles, whereby particles, onto which polymers comprising at least one repeating unit bearing at least one proton-conducting group are grafted, are obtained.
US09446389B2	Hydrocarbon aromatization catalyst composition and method of formation A method for forming a catalyst can comprise: heating a Ge-ZSM-5 zeolite powder at a temperature of 400 to 600° C.; ion-exchanging the heat-treated zeolite powder with an alkali metal and impregnating the heat-treated zeolite powder with noble metal; heating the ion-exchanged, impregnated zeolite powder to a temperature of 250 to 350° C.; mixing the second heat-treated zeolite powder with a solid silica binder and a colloidal silica binder to form a mixture, wherein if the solid silica has a purity of less than or equal to 66 wt % of silica oxide based on the total weight of the solid silica, then the mixture is free of an extrusion aide and the colloidal silica has a particle size of less than 20 nm as measured along a major axis; forming the mixture into a shaped body; and heating the shaped body to 100 to 350° C. to result in the catalyst.
US09446388B2	Metal complex of fluorinated tin oxide and titanium oxide and preparation method thereof Disclosed is a metal complex including: a tin oxide; titanium oxide nanorods in a rutile phase formed on the tin oxide; and titanium oxide nanoparticles in an anatase phase formed on the titanium oxide nanorods in a rutile phase, and a preparation method thereof, and can be used as a catalyst support in various forms.
US09446387B2	Catalysts for petrochemical catalysis Metal oxide catalysts comprising various dopants are provided. The catalysts are useful as heterogenous catalysts in a variety of catalytic reactions, for example, the oxidative coupling of methane to C2 hydrocarbons such as ethane and ethylene. Related methods for use and manufacture of the same are also disclosed.
US09446383B2	In-line mill assembly with spreader ring The system and method requiring a diverter plate for an in-line mill. The plate for use with the in-line mill includes an aperture for passage of particulate laden fluid therethrough and a plurality of tabs such that the fluid and the particulate entrained thereon is deflected at a variety of axial angles. The diverter plate thus provides a reliable method such that the milling process and component wear resistance is made more efficient thereby.
US09446381B2	Hydrocarbon oil desulfurization adsorbing agent, production and use thereof This disclosures provides an adsorbent which, on the basis of the total weight of the adsorbent, comprises: 1) a Si—Al molecular sieve having an A-FAU structure, wherein A represents a monovalent cation, in an amount of 1-20 wt %, 2) at least one binder selected from the group consisting of titanium dioxide, stannic oxide, zirconium oxide and alumina, in an amount of 3-35 wt %, 3) a silica source, in an amount of 5-40 wt %, 4) zinc oxide, in an amount of 10-80 wt %, and 5) at least one promoter metal selected from the group consisting of cobalt, nickel, iron and manganese, based on the metal, in an amount of 5-30 wt %, wherein at least 10 wt % of the promoter metal is present in a reduced valence state. This adsorbent exhibits improved activity and stability, and at the same time, is capable of significantly improving the octane number of the product gasoline.
US09446371B2	Method for treating a substance with wave energy from an electrical arc and a second source A substance is treated using a device having: (a) a volute or cyclone head, (b) a throat connected to the volute or cyclone head, (c) a parabolic reflector connected to the throat, (d) a first wave energy source comprising a first electrode within the volute or cyclone head that extends through the outlet into the opening of the throat along the central axis, and a second electrode extending into the parabolic reflector and spaced apart and axially aligned with first electrode, and (e) a second wave energy source disposed inside the throat, embedded within the throat or disposed around the throat. The substance is directed to the inlet of the volute or cyclone head and irradiated with one or more wave energies produced by the first and second wave energy sources as the substance passes through the device.
US09446368B2	Mixing device for mixing raw material and catalyst in fluid catalytic cracking device A mixing device used in a fluidized catalytic cracking apparatus which mixes feed and a catalyst includes a cylindrical reaction container which supplies a catalyst in a vertical direction; a plurality of feed injection nozzles arranged along an outer circumference of the reaction container; and a catalyst flow regulator which is provided in the reaction container and regulates a flow of the catalyst in the vicinity of the feed injection nozzles. The catalyst flow regulator has no feed supply function and forms a catalyst moving bed having a hollow tubular shape which is coaxial with the reaction container in the vicinity of the feed injection nozzles. The catalyst flow regulator can effectively prevent backward flow of injected fuel. Although the mixing device has a simple structure, it has a high cracking rate and maintenance of the fluidized catalytic cracking apparatus can be performed easier.
US09446367B2	Joint design for segmented silicon carbide liner in a fluidized bed reactor Segmented silicon carbide liners for use in a fluidized bed reactor for production of polysilicon-coated granulate material are disclosed, as well as methods of making and using the segmented silicon carbide liners. Non-contaminating bonding materials for joining silicon carbide segments also are disclosed. One or more of the silicon carbide segments may be constructed of reaction-bonded silicon carbide.
US09446366B2	Modular flow reactor A modular flow reactor is formed of a plurality of modules, wherein each module comprises a body having at least one conduit passing therethrough, and wherein a plurality of said modules are aligned along a longitudinal axis such that said conduits of said modules are aligned to form a passage for fluid, wherein each module has a length along said longitudinal axis which is less than the length of the module perpendicular to the longitudinal axis. The modules are “slices” rather than “tubes” and a plurality of said modules can be aligned linearly so that the conduits form a tube.
US09446362B2	Process and device for unloading particulate material from a vessel The present invention concerns a process for unloading a bed (2) of particulate material from a vessel (1), which comprises inserting a removable and portable extraction pipe (4) into the lower part of said bed, injecting a fluidization gas upwardly into the extraction pipe (4) from the bottom part thereof, along the entire length of the extraction pipe (4), and applying a positive pressure differential between the inlet and the outlet of said extraction pipe.The present invention further concerns a device suitable for implementing such a process.
US09446361B2	Method of densifying coffee A method of controlling coffee density exiting from a coffee densifier is disclosed. The method includes the steps of feeding a ground coffee into a mixing chamber having a discharge door. A mixer motor load on a mixer motor driving mixing members agitating the ground coffee in the mixing chamber is measured. The discharge door is moved when the mixer motor load is outside a predefined mixer motor load operating range.
US09446358B2	Process and apparatus of mixing a fluid within a vessel This invention relates to a process and an apparatus for mixing a fluid or a liquid within a vessel or a tank. The invention includes an apparatus with an inlet device and a mixer. The invention mixes crude oils and/or other hydrocarbon materials to a homogenous state with surprising and unexpected high efficiency. The invention includes methods of using the apparatus to mix the contents of the vessel and/or two stratified materials. The invention includes the ability to mix materials having disparities in density and/or viscosity.
US09446356B2	Ultrasonic dispersion apparatus, system, and method An apparatus, system, and method of dispersing solid forms of drugs or medications reliably and consistently may generally employ ultrasonic energy. The disclosed embodiments facilitate preparation of a liquid dose from solid medications for administration to a patient.
US09446355B2	Porous polymeric membrane with high void volume Membranes comprising first and second surfaces, the first surface comprising a patterned surface comprising peaks and valleys, first region surfaces comprising peaks, and second region surfaces comprising valleys; a porous bulk between the surfaces, the bulk comprising first region bulks and second region bulks; the region bulks extending from their respective region surfaces, the first region bulks comprising a first set of pores having outer rims, and a second set of pores connecting the outer rims of the first set of pores, and a first polymer matrix supporting the first set of pores; the second region bulks comprising a third set of pores having outer rims, and a fourth set of pores connecting the outer rims of the third set of pores, and a second polymer matrix supporting the third set of pores; filters including the membranes, and methods of making and using the membranes, are disclosed.
US09446352B2	Atmosphere-cleaning device for vehicles An object of this invention is to provide an atmosphere-cleaning device for vehicles that is capable of restoring the function of an ozone purifying body carried by a vehicle component. Mud, dust, snow-melting agents as well as SOx and NOx are scattered into the atmosphere as a result of being swirled up by a preceding vehicle or due to weather and climate conditions. When such extraneous substances adhere or the like to an ozone purifying body, the purification sites thereof are clogged and the ozone purification function deteriorates. Therefore, when a predetermined removal implementation condition is established, control is executed to inject cleaning liquid from an injector to enhance the fluidity of the extraneous substances and wash the extraneous substances away. The function of the ozone purifying body can thereby be restored.
US09446347B2	Method of obtaining carbon dioxide from a carbon dioxide-containing gas mixture Disclosed are methods of obtaining carbon dioxide from a CO2-containing gas mixture. The methods combine the benefits of gas membrane separation with cryogenic temperatures.
US09446345B2	Desulfurization device Provided are a downward-inclined-flow passage to which flows flue gas from the flue path connecting a boiler with a stack, a sprayer arranged upstream in the downward-inclined-flow passage to inject absorbing liquid absorptive of sulfur oxides in a direction same as that of flue gas flow, an upward-inclined-flow passage to guide flue gas from the downward-inclined-flow passage to the flue path, a reservoir arranged between lower ends of the flow passages, an auxiliary sprayer arranged in the downward-inclined-flow passage downstream of the sprayer to inject absorbing liquid for uniformization thereof in the downward-inclined-flow passage and a baffle plate arranged in the downward-inclined-flow passage downstream of the auxiliary sprayer and in an upper zone of the flow passage to throttle the flow-passage inner diameter.
US09446339B2	Air filter element with retaining geometry Disclosed is an air filter element (200) for insertion into an air filter housing, comprising an intake surface (275), a discharge surface (285), a filter medium (210), and a filter element-retaining device (240) which extends along at least a section of the periphery of the filter medium (210), between the intake surface (275) and the discharge surface (285), and which includes a retaining arrangement (270) that radially projects from the filter medium (210).
US09446338B2	Filter part for fluid lines A filter part for fluid lines, preferably high-pressure lines with pressures in the range of 150 to 900 bar, preferably in the range of 200 to 350 bar, more preferably in the range of 700 to 875 bar, for use especially in filling nipples, non-return valves, pressure regulators, cylinder valves, filling couplings, switching valves, break-off safety devices, quick couplings and also as a separate filter part. The filter part comprises a base body and at least one fluid passage opening, wherein the base body and the fluid passage opening are covered by at least one filter element. The invention further relates to a method for producing a filter part with a base body and a filter element, especially in form of a screen filter which is also known as a filter mesh.
US09446333B2	Keyed thread engagement on spin-on filter element A filter element includes a ring of filtration media circumscribing a central axis and defining a central cavity. An annular end cap of the filter element is sealingly bonded at an end of the media. The end cap includes a central opening into the central cavity, and a lateral opening spaced laterally outward from the central opening. The central opening includes a threaded connection portion to enable the element to be spun-on to a complimentarily-threaded connection portion of a filter head. The connection portion of the central opening includes at least one axially-extending slot opening radially away from the connection portion.
US09446328B2	Filtration medium comprising a metal-containing particulate Described herein is a liquid filtration device is disclosed comprising a fluid conduit fluidly connecting a fluid inlet to a fluid outlet; and a water filtration medium disposed in the fluid conduit; the water filter medium comprising a metal-containing particulate, wherein the metal-containing particulate comprises a thermolysis product of a metal salt wherein the salt is selected from nitrogen-containing oxyanions, sulfur-containing anions, chlorides, phosphates, and combinations thereof; and methods of removing chloramines from aqueous solutions.
US09446327B2	Liquid distribution device The present invention is capable of precisely controlling a supply ratio of liquid and continuously supplying liquid at a constant rate by using partition plates for controlling the amount of liquid distribution.
US09446326B2	Method and apparatus for ethanol production An integrated bioethanol production and evaporation process and system produce reduces high quality ethanol and concentrated stillage. The process and system provide a significant energy savings over conventional bioethanol production and evaporation systems by using the energy (“vapor”) that drives the distillation process to also drive a multiple effect evaporator, preferably a multiple effect TASTE™ evaporator to “flash” or vaporize alcohol from the distillate. Additional energy savings are provided by passing fermented material through one or more pre-heaters of the multiple effect evaporator to increase the temperature of the fermented material prior to its distillation. The system preferably includes a pre-flash evaporator upstream of an alcohol recovery assembly in the direction of vapor flow and a multi-effect post-flash evaporator downstream of the alcohol recovery assembly.
US09446322B2	Toy horse A toy horse having a horse body, wherein the horse body includes a saddle board, two side boards, each side board being provided with a straight horse-back panel on its top, the two side boards being arranged opposite to each other symmetrically, which makes the horse-back panel of the two side boards being coplanar, the two side boards being removably installed on the saddle board, which makes the horse-back panel of the two side boards being abutted against the bottom of the saddle board, and the bottom of two side boards being shaped curly. The toy horse allows for portability of carry, convenience of assemble and comfortableness of ride.
US09446321B1	Public gameplay A system, computer-readable storage medium storing at least one program, and a computer-implemented method for providing public gameplay is provided. Gameboard display data is generated to display a gameboard of a game. A move associated with the game is received from a client device of a player. The gameboard display data and move display data are provided to the client device to display the move on the gameboard. The gameboard display data and the move display data are also sent to a broadcast server to display the move on the gameboard via a public medium.
US09446320B2	Inserting an operator avatar into an online virtual environment An entertainment device comprises a display generator arranged to generate for display a representation of an on-line virtual environment corresponding to a first instance of a plurality of substantially similar on-line virtual environments and to generate for display within the representation of the on-line virtual environment an avatar controlled by the user of the entertainment device and one or more software-controlled avatars; a data communications arrangement operable to transmit an alert signal in response to a predetermined action of the user of the entertainment device within the first instance of the on-line virtual environment, said signal serving to request interaction with a human operator, the data communications arrangement being further operable to receive a notification signal; the display generator being arranged to respond to the notification signal by changing the mode of a software controlled avatar to represent an additional user of another entertainment device in data communication with the entertainment device, wherein the additional user is an operator whose entertainment device has been switched to the same first instance of the on-line virtual environment as that of the entertainment device in response to the transmitted alert signal; and the data communications arrangement being arranged to exchange information between the user of the entertainment device and the operator within the same first instance of the on-line virtual environment via their respective avatars.
US09446313B2	Device, game and control methods therefor In an embodiment there is provided a device having a user interface configured to display a game board having a plurality of game objects, each game object having one or more characteristics, said user interface being configured to receive user input, and at least one processor in connection or communication with at least one memory configured to detect a selection of at least one game object with respect to said displayed game board in response to player input, re-order said selected game objects on said displayed game board with respect to said input, create a further game object sharing at least one of the one or more characteristics of said re-ordered game objects in accordance with at least one rule stored in said at least one memory, and replace said re-ordered game objects with said further game object for display.
US09446312B2	Video game systems and methods for protecting game characters during game play Example systems and methods relate to playing a multi-player video game in which multiple players each supply inputs to a respective input device to control a corresponding game character in a game world displayed on a display screen. Movements of each game character in the game world are controlled in accordance with respective first game character control operations during the playing of the multi-player video game. In response to satisfaction of one or more conditions, one player's game character is protected from harm in the game world, wherein one of the one or more conditions is a condition triggered voluntarily by the one player. Movements of the protected game character in the game world are controlled based on a position of another, unprotected game character.
US09446309B2	Information processing system, game system, information processing apparatus, recording medium, and information processing method An example system includes: a communication device including a first wireless communication part performing short-distance wireless communication; and an information processing apparatus including a second wireless communication part performing short-distance wireless communication, a processing part performing processing concerning input or output of information, a restriction part, in correspondence to the processing of one of the second wireless communication part and the processing part, restricting the processing of the other, and an information processing part performing information processing corresponding to a processing result of the second wireless communication part or the processing part whose processing is not restricted by the restriction part.
US09446306B2	System and method for local multiplayer gaming A system and method for local multiplayer gaming are disclosed. According to one embodiment, a system comprises a plurality of mobile client devices including a mobile client device designated as a server device. Each mobile client device comprises a display, at least one local network interface for communication with said server device and a processor. The processor is programmed for playing a multiplayer game with other mobile client devices and rendering on said display a game situation depending on commands sent by a plurality of mobile client devices to said server device over said at least local network interface. At least one of said mobile client devices is configured for overhearing commands sent by at least one other mobile client device to said server device or another mobile client device and for rendering on its display a game situation depending on said overheard command.
US09446305B2	System and method for improving the graphics performance of hosted applications A system and method for efficiently processing a video stream using limited hardware and/or software resources. For example, one embodiment of a computer-implemented method for efficiently processing a video stream with a processor pipeline having a plurality of pipeline stages, comprises: identifying a bottleneck stage within the processor pipeline the bottleneck stage processing frames of the video stream; receiving a feedback signal from the bottleneck stage at one or more upstream stages, the feedback signal providing an indication of the speed at which the bottleneck stage is processing the frames of the video stream; and responsively adjusting the speed at which the one or more upstream stages are processing frames of the video stream to approximate the speed at which the bottleneck stage is processing the frames of the video stream.
US09446302B2	Interventive-diagnostic device Apparatus for improving health of a user is provided, including a first sensor, adapted to measure a first physiological variable, which is indicative of a voluntary action of the user. A second sensor is adapted to measure a second physiological variable, which is substantially governed by an autonomic nervous system of the user. Circuitry is adapted to receive respective first and second sensor signals from the first and second sensors, and, responsive thereto, to generate an output signal which directs the user to modify a parameter of the voluntary action.
US09446299B2	Breathable and adjustable fielding glove A baseball fielding glove capable of receiving a human hand is provided. The glove comprises an exterior glove shell and an interior glove liner. The glove comprises a strut in place of traditional webbing. Further, the glove's exterior shell corresponding to the palm of a wearer comprises a plurality of perforations for enhancing ventilation. The fielding glove disclosed is readily adjustable eliminating the need for a breaking-in process. A tensioning cord extending between the strut and finger/thumb stalls of the glove provide an enhanced degree of adjustable characteristics to the glove.
US09446298B2	Roller hockey goalie apparatus A roller apparatus that either attaches to or is incorporated into a roller hockey goalie leg protective member, allowing simulation of “on ice” motion. Rolling may be accomplished through a plurality of ball bearings, protruding from a plane of an apparatus, as well as a plurality of cavities wherein ball bearings may be housed. A recess in the cavities may allow for impact to be absorbed while still allowing the ball bearings to freely roll in one or preferably every direction. Apparatus containing ball bearings may be located on the landings of a roller hockey goalie leg protective member, or other areas most likely to come in contact with a dry surface.
US09446295B2	Tethered training harness Described herein is a training harness comprising: a harness comprising at least one anchor point connecter; and a retractable tether comprising a casing supporting and storing a rotatable spool, a handle grip connected to the casing, a tether comprising a first end coupled to the spool and a second end configured for reversible coupling to the at least one anchor point connecter, an elastic section at or proximal to the second end. The training harness may be used by children learning a sport, particularly a downhill gliding sport such as skiing or snowboarding.
US09446292B2	Golf club heads Putters include a putter body having a ball striking face member made of a material having a first hardness characteristic. A cavity is defined in the putter body behind the ball striking face member, and plural openings are defined in the ball striking face member extending rearward with respect to the ball striking face member and into the cavity. A polymeric material at least partially fills the openings and the cavity, wherein the polymeric material has a second hardness characteristic that is softer than the first hardness characteristic. The ball striking face member and the polymeric material exposed in at least some of the openings provide a ball striking surface of the putter. The ball striking surface may include grooves or scorelines to affect the launch angle, spin, and/or roll of the ball during a putt. Methods for making such putter devices also are described.
US09446291B2	Adjustable golf club Apparatus and methods are described herein to provide a golf club, such as, for example, a putter, with a select loft angle and/or a select lie angle. In some embodiments, an apparatus includes a golf club having a golf club head, a hosel, and a hosel shim. The golf club head has a hosel shank and the hosel is configured to be coupled to the hosel shank. The hosel shim is configured to be coupled to the hosel to position the hosel at a select angle relative to the golf club head such that the golf club has a select lie angle. The hosel shim is further configured to limit rotational movement of the hosel relative to the golf club head such that the select lie angle is maintained when the hosel is coupled to the golf club head.
US09446290B2	Golf ball and method of coating a cover of the golf ball A golf ball comprises a core, a cover formed from an ionomer resin and disposed on the core, and a cured coating layer disposed on and in direct contact with the cover. The cured coating layer is formed from a topcoat coating composition comprising a polymeric component and a halogenated component. The halogenated component is present in an amount of from about 0.5 parts by weight to about 50 parts by weight based on 100 parts by weight of the polymeric component. A method of coating a cover of a golf ball includes applying the topcoat coating composition directly onto the cover. The method also includes, after applying, curing the topcoat coating composition to form a cured coating layer disposed on and in direct contact with the cover to thereby coat the cover.
US09446283B2	Top-loading adjustable weight kettlebell system Preferred top-loading adjustable weight kettlebell systems described herein preferably include a kettlebell base and at least one top-loading nesting weight. The kettlebell base preferably include a main body and a handle, the main body having a substantially convex upper surface, the handle upwardly extended from the main body. The at least one top-loading nesting weight preferably has a handle opening defined therein. The at least one top-loading nesting weight may have a substantially convex upper surface and a substantially concave lower surface. The at least one top-loading nesting weight is preferably loadable onto the kettlebell base by insertion of the handle through the handle opening. Preferred top-loading adjustable weight kettlebell systems may include a two-part securing mechanism for securement between the kettlebell base and the at least one top-loading nesting weight.
US09446280B2	Apparatus for resistance-based fitness training An improved resistance-based fitness apparatus which may be transformed in multiple temporary yet stable shapes by the user, such that the all or some apparatus subsections may move freely be immobilized in a fixed position or manipulated by the user into various shapes. An improved joint-based connector apparatus which may enable the improved resistance-based fitness apparatus to be transformed into multiple temporary yet stable shapes with subsections that are either freely moving, immobilized in a fixed position, or a combination thereof. This improved joint may connect one or more objects while also providing for three-dimensional non-coplanar movement that may be selectively locked or unlocked at a variety of angles by a single activating action (e.g., pressing a button). The improved joint may also be fashioned into useful devices in various other arts beyond the fitness arts.
US09446278B2	Bicycle speed/resistance attachment An exercise assembly useful in training a bicyclist for increased speed includes a pair of elastic straps adjustable in their length to stretch between the rear axle of the bicycle and the bicyclist's respective thighs. The strap attachment to the thighs is effected by a corresponding pair of adjustable elastic hoops that are limited in their elastic expansion by fabric strips attached to each of the hoops at loosely spaced intervals. A set of elastomeric wraps may be further interposed between the thighs and the hoops to expand the contact area and therefore the shear load capacity of the engagement to limit any axial translation of the engagement along the thigh. When not in use the straps can be attached to the bicycle frame both when implemented as a stationary bicycle or when on the road.
US09446275B2	Purging water in a waterpark reservoir by inducing a siphon Disclosed herein is a method for purging water in a waterpark reservoir by inducing a siphon and several examples of an apparatus to achieve this result. The apparatus disclosed herein provides an emptying mechanism which may have no moving parts or valves between the inlet and the outlet and yet delivers a short term large volume dump or purge of water to patrons in an impact area of a patron region of a waterpark.
US09446271B1	Fire and smoke prevention compositions and the processes of making them A sodium polyacrylate and distilled water composition for fire and smoke prevention, suppression or extinction, and methods of making and using the same.
US09446268B2	Extinguishing flammable liquid fire in an industrial storage tank A system and apparatus for extinguishing a fire of a difficult to extinguish fuel or flammable liquid in a storage tank fitted with at least a significant top roof portion, the system including timely discharge of dry powder into a significantly enclosed space or cavity defined between the fuel/liquid surface, or between any floater remaining thereon, and the fixed top roof portion, and apparatus to facilitate the system.
US09446267B2	Products comprising a flavoring agent composition The present invention primarily concerns teeth cleaning compounds containing menthol for use with a toothbrush, preferably tooth pastes, tooth crèmes, tooth cleaning gels or tooth powders. Such a tooth cleaning compound according to the invention contains menthol and a quantity, for masking the bitterness of the menthol, of menthane carboxylic acid-N-(4-methoxyphenyl)-amide (WS-12) of the following formula (Ia), in particular of the following formula (Ib), i.e. L-menthane carboxylic acid-N-(4-methoxyphenyl)-amide. The present invention also concerns the use of menthane carboxylic acid-N-(4-methoxyphenyl)-amide (WS-12) of the formulas (Ia) or (preferably) (Ib) to mask the bitter taste of menthol in a teeth cleaning compound.The present invention also concerns a method for dissolving menthane carboxylic acid-N-(4-methoxyphenyl)-amide (WS-12) in a teeth cleaning compound and a method for masking the bitterness of menthol in a teeth cleaning compound.
US09446261B2	Billing system for video provisioning system A method, performed by a video provisioning system, may include receiving a request to purchase a video asset from a user device. The method may further include determining an account type associated with the user device; billing the purchase to a bundled services account, where the bundled services account is associated with one or more of a television service, a data connection service, or a telephone service delivered over a same connection, when the account type corresponds to the bundled services account; billing the purchase to a voice services account, where the voice services account corresponds to a telephone service, when the account type corresponds to the voice services account; and processing a payment for the purchase via an online payment service, when the user device is not associated with a bundles services account or a voice services account.
US09446260B2	Computer controlled laser therapy treatment table A multi-function, adjustable chiropractic table comprises a body section fixed to a table frame. A cervical section is pivotally attached to the table frame and securable at a desired angle. The cervical section comprises a padded head support, forehead strap, and neck bolsters. The head support is slidably mounted in a tray and translatable therein using a scissors mechanism, for linear axial traction. Pivotally mounting the tray to the cervical section permits lateral traction. A four-bar linkage, including a base frame, permits raising/lowering of the table using an actuator activated by a foot triggered wave switch comprising proximity sensors. The body section comprises a chest, lumbar, and leg sections. The chest section is replaceable with a treatment module comprising hot and cold compresses, or a laser enhanced spinal decompression therapy apparatus comprising a laser driven by two linear actuators to emit light according to one or more treatment protocols.
US09446257B2	Automated external defibrillator support mechanism According to an embodiment of the present invention, an apparatus includes an automated external defibrillator including at least one display. The apparatus also includes a support mechanism for supporting the automated external defibrillator. The support mechanism includes a stand connected to a hinge that is connected to the automated external defibrillator. The hinge is capable of placing the stand in a deployed position for supporting the automated external defibrillator during operation and is capable of placing the stand in a stowed position for storing the automated external defibrillator.
US09446256B2	Atrial activity signal estimation using independent component analysis A single-chamber implantable device for detecting a patient's atrial activity using a monobody lead is disclosed. The monobody lead (10) includes a ventricular coil (16), a supraventricular coil (18), a distal electrode (14) forming three electrodes for detecting depolarization signals. A generator (12) of the implantable device collects a first unipolar signal (20) between the ventricular coil and the generator housing and a second unipolar signal (22) between the supraventricular coil and the generator housing. An independent component analysis is performed to the detected depolarization signals to determine an estimated atrial activity signal from the first and second unipolar signals.
US09446255B2	Controlled stimulation delivery from neurostimulator A system for providing neurostimulation includes an external device (“external exciter”) and an implanted device. The external exciter includes an energy source which inductively powers the implanted device. Examples of such external exciters include devices having at least one of: ultrasonic transducers, Radio Frequency (RF) transmitters, and solar cells. The implanted device includes circuitry that limits its maximum energy output to a predetermined saturation threshold such that excess stimulation from the external exciter does not raise the output of the implanted device beyond the saturation threshold. The output signal of the external exciter is then pulse-width modulated in order to produce a desired amount of output stimulation from the implanted device to stimulate the bioelectrically excitable tissue at a desired level.
US09446254B2	Charger alignment in an implantable medical device system employing reflected impedance modulation The disclosed means of determining alignment between an external charger and an implantable medical device (IMD) involves the use of reflected impedance modulation, i.e., by measuring at the external charger reflections arising from modulating the impedance of the charging coil in the IMD. During charging, the charging coil in the IMD is pulsed to modulate its impedance. The difference in the coil voltage (ΔV) produced at the external charger as a result of these pulses is assessed and is used by the external charger to indicate coupling. If the magnitude of ΔV is above a threshold, the external charger considers the coupling to the IMD to be adequate, and an alignment indicator in the external charger is controlled accordingly. The magnitude of Vcoil can be assessed in addition to ΔV to determine alignment with the IMD with improved precision, and/or to further define a high quality alignment condition.
US09446248B2	Interventional medical systems, tools, and methods of use Delivery tools of interventional medical systems facilitate deployment of relatively compact implantable medical devices that include sensing extensions, for example, right ventricular cardiac pacing devices that include a sensing extension for atrial sensing. An entirety of such a device is contained within a delivery tool while a distal-most portion of the tool is navigated to a target implant site; the tool is configured to expose, out from a distal opening thereof, a distal portion of the device for initial deployment, after which sensing, via a sense electrode of the aforementioned sensing extension of the device, can be evaluated without withdrawing the tool from over the remainder of the device that includes the sensing extension.
US09446247B2	System and method for stimulating the heart using sub-threshold biphasic stimulation A rules engine acquires sensor data from sensors applied to the heart and determines whether an electrical waveform should be applied to the heart and, if so, the type of electrical waveform. A multiphase cardiac stimulus generator generates waveforms in response to the rules engine. The electrical waveform is applied to one or more electrodes implanted in or on the heart.
US09446243B2	Patient posture determination and stimulation program adjustment in an implantable stimulator device using impedance fingerprinting Methods and circuitry for determining an implanted-neurostimulator patient's position, and adjusting a situation program delivered by the neurostimulator based on the determined position, is disclosed. Impedance measurements of the patient's tissue are taken at the neurostimulator's electrodes, which measurements can comprise complex impedance measurements (magnitude and phase) taken at different frequencies. Such impedance measurements, which can be taken interleaved with stimulation therapy, are used to determine an “impedance fingerprint.” This fingerprint can be compared to other known fingerprints stored in the IPG, which known fingerprints are associated with particular stimulation programs. When a measured fingerprint matches one stored in the IPG, the stimulation program associated with the stored fingerprint is automatically used for patient therapy. As different measured fingerprints are encountered, the IPG can learn and store a new stimulation program for such fingerprint by remembering stimulation parameters selected by the patient when such fingerprint is encountered.
US09446241B2	Current sensing multiple output current stimulators A multiple output current stimulator circuit with fast turn on time is described. At least one pair of input side and output side transistors is arranged in a current mirror connected to a supply transistor by cascode coupling. The output side transistor supplies stimulation current to an electrode in contact with tissue. An operational amplifier connected to a reference voltage and to the output side transistor drives the supply transistor to maintain the voltage at the output side transistor equal to the reference voltage. The at least one pair of transistors includes multiple pairs of transistors whose output side transistors drive respective electrodes with stimulation currents. The stimulator determines the initiation and duration of stimulation current pulses supplied to each electrode. At circuit activation, large currents are generated which discharge capacitances in the output side transistors causing rapid output side transistor turn on.
US09446240B2	System and method for neuromodulation A method of treating autonomic imbalance in a patient includes energizing a first therapeutic element disposed to deliver therapy to a parasympathetic nerve fiber (e.g. vagus nerve), and energizing a second therapeutic element to deliver therapy to a sympathetic cardiac nerve fiber. At least one of the therapeutic elements is disposed in the vasculature superior to the heart. The therapy decreases the patient's heart rate and elevates or maintains the blood pressure of the patient.
US09446238B2	Deep brain stimulation of the subcallosal cingulate area for treatment of refractory anorexia nervosa In one embodiment, a method of treating an eating disorder in a patient, comprises: diagnosing the eating disorder in the patient; and electrically stimulating a subgenual cingulate cortex site or a ventral medial prefrontal cortex site in the patient using electrodes of an implanted stimulation lead.
US09446235B2	Low frequency electrical stimulation therapy for pelvic floor disorders In some examples, relatively low frequency (e.g., less than about 50 Hertz) electrical stimulation therapy is delivered to a target tissue site proximate to one or more of the T9, T10, T11, T12, L1, L2, or L3 (“T9-L3”) spinal nerves of a patient to manage a pelvic floor disorder, such as urinary retention, fecal retention, or both. The relatively low frequency electrical stimulation therapy is configured to excite the one or more of the T9-L3 spinal nerves, which may generate an activating response from the patient related to voiding and help promote voiding by the patient. For example, the low frequency electrical stimulation may be configured to help improve the patient's pelvic sensations, which may help the patient better control urination.
US09446234B2	Gastric electrical stimulation with lockout interval anti-desensitization feature The disclosure is directed to gastric stimulation programmers, stimulators and methods for controlling delivery of gastric stimulation therapy to maintain the efficacy of the therapy over time. Maintaining the efficacy of gastric stimulation therapy may be possible by implementing one or more anti-desensitization features in a gastric stimulation controller or stimulator. As electrical stimulation therapy is continuously delivered to a patient, the stimulated tissue may become desensitized to the electrical stimulation therapy such that the beneficial effect of the electrical stimulation is diminished. Once desensitization occurs, the affected tissue may not respond favorably to electrical stimulation therapy. Application of one or more anti-desensitization features to control gastric stimulation therapy may reduce or prevent desensitization and effectively extend the efficacy of the therapy over time.
US09446227B2	Ultrasonic dispersion of compositions in tissue Therapeutic agents, diagnostic agents and other compositions can be effectively delivered to target tissues using ultrasonic dispersion. For example, a therapeutic agent in solution may be injected subcutaneously in the vicinity of a target tissue in a patient. External ultrasound is used to disperse the therapeutic agent in the target tissue. The disclosed methods provide increased concentrations of therapeutic agents in tissue relative to traditional delivery methods, thereby improving therapeutic outcomes while reducing costs. In addition the methods can be used to deliver effective concentrations of therapeutic agents to tissues with limited blood supply.
US09446223B2	Method of making a balloon dilation catheter shaft having end transition A catheter includes a balloon and a shaft having a coaxial portion including an outer tubular member having a bore, a transition neck, an access fitting adjacent the proximate end of the catheter shaft for directing a guidewire into the catheter shaft, an inflation port, a guidewire tubular member disposed coaxially in the outer tubular member, the outer tubular member and guidewire tubular member defining a first, annular inflation/deflation lumen fluid communication with the inflation port, at least one second inflation/deflation lumen separate from and non-coaxial with the guidewire tubular member and having a cross-sectional area less than the cross-sectional area of the first inflation/deflation lumen and opening at a proximate end into the first inflation/deflation lumen and at the distal end of the transition neck.
US09446220B2	Guide wire utilizing a cold worked nickel—titanium—niobium ternary alloy Guide wire devices fabricated from a linear pseudo-elastic Ni—Ti alloy and methods for their manufacture. The Ni—Ti alloy that includes nickel, titanium, and about 3 atomic % (at %) to about 30 at % niobium (Nb). Cold working the Ni—Ti alloy stabilizes the alloy's martensitic phase and yields a linear pseudo-elastic microstructure where reversion to the austenite phase is retarded or altogether blocked. The martensitic phase of cold worked, linear pseudo-elastic Ni—Ti—Nb alloy has an elastic modulus that is considerably higher than the comparable cold worked, linear pseudoelastic binary Ni—Ti alloy. This yields a guide wire device that has better torque response and steerability as compared to cold worked, linear pseudoelastic binary Ni—Ti alloy or superelastic binary Ni—Ti alloy.
US09446218B2	Microcatheter tip The present invention is directed to a dilator having a stiffened shaft for use as part of an introducer sheath assembly. The dilator includes a stiffener tube and a tip of the dilator which extends distally to the dilator stiffener tube. The transition between the stiffener tube and the tip of the dilator is positioned such that when the dilator is positioned within the catheter sheath, the transition is also positioned within the catheter sheath. By positioning the transition between the stiffener tube of the dilator and the tip of the dilator inside the catheter sheath, the catheter sheath can provide strain relief subsequent to lateral movement of the tip of the dilator in a manner that can prevent kinking of the dilator tip at the transition between the stiffener tip and the tip of the dilator.
US09446216B2	Cannular device and method of manufacture A cannula comprising a polymeric material which is phthalate-free, yet retains flexibility, workability and elongation properties so as to avoid kinking when bent. Also disclosed is a method of manufacturing a cannular device comprising extruding a flexible, biocompatible, phthalate-free polymeric composition through a round die into a tube, pulling the tube through a water bath at a rate established according to a predetermined function, and cutting the tube to for a cannular device, wherein the predetermined function periodically modulates a pulling rate.
US09446213B2	Tracheal tube In an embodiment, a tracheal tube system has a first tube, which is flexible. The tube has an opening that is located on the sidewalls. A balloon is attached to the flexible tube. When inflated, the balloon forms a second tube surrounding the first tube with an air space between the first wall of the balloon and the sidewalls of the first tube. The balloon extends covering the opening on the sidewall. Air flowing into the first tube exits, via the third opening into the airspace between the first tube and the balloon, out of the airspace. In another embodiment, the balloon has a tube with multiplicity of holes in the walls is wrapped around the outer wall of the balloon. Negative pressure in the third tube creates suction holding the outer wall of the balloon to walls of the trachea.
US09446210B2	System and method of monitoring breathing Sidestream sampling of gas to determine information related to the composition of gas at or near the airway of a subject is implemented. From such information one or more breathing parameters of subject 12 (e.g., respiratory rate, end-tidal CO2, etc.) are determined, respiratory events (e.g., obstructions, apneas, etc.) are identified, equipment malfunction and/or misuse is identified, and/or functions are performed. To improve the accuracy of one or more of these determinations, information related to pressure at or near the airway of subject is implemented. This information may include detection of pressure at or near a sidestream sampling cell.
US09446207B2	Nozzle unit and dispenser A nozzle unit for discharge of a pharmaceutical medium and a dispenser equipped therewith. The nozzle unit includes a common supply channel for supply of the medium and first and second discharge nozzles each having a discharge orifice for discharge of the medium supplied through the common supply channel. The nozzle unit is configured for atomized delivery of the medium and includes a first vortex chamber assigned to the first discharge nozzle and a second vortex chamber assigned to the second discharge nozzle for the purpose of atomizing.
US09446202B2	Drive mechanism for a drug delivery device and resilient element for a drive mechanism A plunger (4) having engaging means and a lever (5) are arranged in a body (1). The lever has a first pivot that is stationary with respect to the body in the direction of an axis, a second pivot, and a third pivot formed by an engaging element of the lever. The pivots are arranged in such a manner that a rotation of the lever with respect to the first pivot moves the second pivot and the third pivot in the same direction with respect to the axis. The engaging element and the engaging means are shaped such that the lever is disengaged from the plunger when the second pivot is moved relatively to the plunger in the proximal direction (30), and the plunger is engaged with the lever when the second pivot is moved in the distal direction (20).
US09446197B2	Intranasal cartridge devices Intranasal delivery devices include dosage forms containing medical compositions for use in the intranasal devices, and methods of delivering medical compositions to the nasal mucosa of users. The devices dispense a predetermined quantity of fluid into the nasal passage of a user, in which the predetermined quantity of fluid is contained in, or produced in a dosage form or blister that is crushed by a plunger with sufficient force to drive the dosage form against a piercing mechanism, piercing the dosage form and forcing the liquid contents from the dosage form and through a delivery channel into a spray to be directed into the nasal passage of a user. The plunger is connected to a trigger device by a linkage that confers a mechanical advantage to the trigger mechanism.
US09446196B2	Auto-injector An auto-injector comprises a chassis to contain a syringe with a, needle and a stopper, a needle shroud slideable within the chassis and adapted to rest on the skin of a patient, a plunger adapted to translate the stopper to expel medicament, a coupling shroud slideable within the chassis and releasably coupled to the plunger and a drive means, the drive means driving the coupling shroud proximally from a first position Proximal movement of the coupling shroud translates the syringe exposing the needle, depresses the plunger to expel medicament and advances the needle shroud to a safe position to surround the needle. The needle shroud arranged to prevent decoupling of plunger and coupling shroud when the needle shroud is in a retracted position, whereas the needle shroud is arranged to allow decoupling of plunger and coupling shroud when the needle shroud is moved towards the safe position.
US09446195B2	Injection device with cammed ram assembly An exemplary embodiment of the present disclosure can provide an injector including a trigger mechanism, an energy source, and a user-operable firing-initiation member. The trigger member can include a trigger member having a retainer portion, and a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom and a trigger engagement member configured to engage the retainer portion of the trigger member in a pre-firing condition. The energy source can be associated with the ram for powering the ram to expel the medicament, and the user-operable firing-initiation member can be operable for causing an axial rotation between the trigger engagement member and the retainer portion from the pre-firing condition to a firing condition in which the trigger engagement member is released from the retainer portion to allow the energy source to fire the ram.
US09446185B2	Devices and methods for improving accuracy of fluid delivery Devices and methods for delivering therapeutic fluid to a patient's body are described. The devices may comprise a dispensing unit having a reservoir, a driving mechanism having a movable member for delivering therapeutic fluid to a patient's body, at least one sensor for sensing a relative position of the movable member and generating a signal, and a processor for controlling the driving mechanism to deliver an amount of therapeutic fluid that compensates for a change in the flow of the therapeutic fluid occurring during fluid delivery. The methods may be implemented by operating the driving mechanism, receiving a signal based on the position of the movable member, determining an amount of therapeutic fluid to deliver, and controlling the driving mechanism to deliver an amount of fluid that compensates for a change in flow occurring during fluid delivery.
US09446184B2	Infusion preparation An object of the present invention is to provide an infusion preparation in which the Maillard reaction between an amino acid and a reducing sugar does not occur during storage and the size of fat particles in the fat emulsion does not increase during storage, and in which various types of vitamins can be incorporated in a stable manner, in spite of the fact that it is a two-chamber infusion preparation. Furthermore, even if only one of the infusions (of the infusion preparation) is administered, the patient is unlikely to develop hyperkalemia, vascular pain, or phlebitis. The present invention provides an infusion preparation containing two chambers separated by a partition that can be communicably opened, wherein a first chamber contains a first-chamber infusion containing a sugar and a fat emulsion, a second chamber contains a second-chamber infusion containing an amino acid and an electrolyte, the first-chamber infusion is substantially free of potassium, and has a relative osmotic pressure of 2.0 to 3.0, the second-chamber infusion has a potassium concentration of 40 mEq/L or less and a relative osmotic pressure of 2.5 to 3.5, and a mixture of the first- and second-chamber infusions has a potassium concentration of 16 mEq/L or more as measured upon communicably opening the partition.
US09446179B2	Distal bearing support In various embodiments, a catheter pump is disclosed herein. The catheter pump can include an elongated catheter body having a distal portion including an expandable cannula having an inlet and an outlet. The expandable cannula can have a delivery profile and an operational profile larger than the delivery profile. An impeller assembly can include an impeller shaft, and an impeller body can include one or more blades. The impeller blades can draw blood into the cannula when rotated. Further, an expandable support can have a mounting portion disposed on the impeller shaft distal of the impeller body and a cannula contact portion for reducing a change in tip gap due to bending of the cannula. The cannula contact portion can be disposed distal of the mounting portion.
US09446178B2	Wound cleansing apparatus in-situ An apparatus for cleansing wounds, in which wound exudate is removed from a wound bed and selectively cleansed and returned to the wound. The cleansing means removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The associated wound dressing and cleansing means are conformable to the wound, and may have irrigant fluid circulated from a reservoir by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing.
US09446170B2	Multiphasic bone graft substitute material The invention provides a particulate composition adapted for forming a bone graft substitute cement upon mixing with an aqueous solution, comprising i) a calcium sulfate hemihydrate powder, wherein the calcium sulfate hemihydrate is present at a concentration of at least about 50 weight percent based on the total weight of the particulate composition; ii) a monocalcium phosphate monohydrate powder; iii) a non-porous β-tricalcium phosphate powder; and iv) a porous β-tricalcium phosphate powder. Bone graft substitute cements made therefrom, a bone graft substitute kit comprising the particulate composition, methods of making and using the particulate composition, and articles made from the bone graft substitute cement are also provided.
US09446165B2	Swellable fiber and microfiber forming polyether-esters and applications thereof Biomedical and tissue engineering devices, such as surgical sutures and microporous scaffolds, respectively, which undergo swelling and increase in dimensions when placed in aqueous environments such as living tissues, are produced by the melt-spinning or electrostatic spinning into strong monofilament and multifilament yarns or microfibrous fabrics, respectively. Such devices are formed from especially high molecular weight crystalline polyether-esters having a minimum inherent viscosity of 0.8 dL/g and heat of fusion of at least 5 J/g, wherein the polyether-esters are made by grafting to a polyester component a polyether glycol component having a minimum molecular weight of about 11 kDa with at least one cyclic monomer.
US09446164B2	Surgical sutures incorporated with stem cells or other bioactive materials Materials and methods for immobilizing bioactive molecules, stem and other precursor cells, and other agents of therapeutic value in surgical sutures and other tissue scaffold devices are described herein. Broadly drawn to the integration and incorporation of bioactive materials into suture constructs, tissue scaffolds and medical devices, the present invention has particular utility in the development of novel systems that enable medical personnel performing surgical and other medical procedures to utilize and subsequently reintroduce bioactive materials extracted from a patient (or their allogenic equivalents) to a wound or target surgical site.
US09446161B1	Fragrance compositions containing low vapor pressure VOC solvents A fragrance composition comprising a low vapor pressure VOC and at least one low vapor pressure VOC potentiator compound, which reduces, or altogether completely obviates the use of HVPVOC solvents in fragrance compositions.
US09446160B2	Chlorine dioxide gas generator A chlorine dioxide gas generator including a frame body which houses a first chemical tank which is filled with a first chemical containing chlorite, a second chemical tank which is filled with a second chemical containing acid, a reactor which causes a reaction between the first chemical containing chlorite and the second chemical containing acid, and a separation tank which separates a chlorine dioxide gas from a chlorine dioxide solution generated in the reactor, the chlorine dioxide gas generator being adapted to disinfect an enclosed space by means of the chlorine dioxide gas.
US09446159B2	Flow cytometer biosafety hood and systems including the same Flow cytometer systems are provided that mitigate aerosols generated during operation of a flow cytometer. A flow cytometer system can include various combinations of: a flow cytometer instrument base, a flow cytometer, and a biosafety hood (BSH). In some embodiments, a subject flow cytometer system includes a flow cytometer instrument base, a flow cytometer, and a BSH. In some embodiments, a subject flow cytometer system includes a flow cytometer instrument base and a flow cytometer. In some cases, a BSH includes an aerosol management system, which provides a redundant air filtration system. Also provided are components of a flow cytometer system (e.g., a BSH configured to attach to a flow cytometer instrument base, a flow cytometer instrument base configured to attach to a BSH, etc.). Also provided are methods, including methods of performing a flow cytometric procedure using a flow cytometer system; and methods of decontaminating a flow cytometer system.
US09446157B2	Chelated PSMA inhibitors Compounds as defined herein are provided which are useful in (1) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention together with a pharmaceutically acceptable diluent; and (3) methods for imaging prostate cancer cells.
US09446151B2	In vivo imaging of enzymatic activity Compositions and methods are described for detecting enzyme activity in a live organism (e.g., animal) are provided.
US09446150B2	Particles for imaging The invention encompasses particles comprising metal atoms, methods of making the particles, and methods for using the particles. In particular, the particles may be used to image biological tissues or to deliver a bioactive agent.
US09446148B2	Carrier-antibody compositions and methods of making and using the same Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic.
US09446147B2	Membrane stabilizing compositions and methods A sugar-anchor polymer and methods of making and using the same to stabilize a lipid membrane. The sugar-anchor polymer includes a sugar covalently bound to a first anchor and a second anchor wherein the covalent bonds are selected from the group consisting essentially of an oxime bond, a hydrazone bond, an acylhydrazide bond, an aminothioacetal bond, an acetal bond, a thioacetal bond, a dithioacetal bond, a thioether bond and combinations thereof. The method includes reacting a sugar having at least two nucleophilic moieties with at least two anchors, each anchor having at least one electrophilic moiety, to form the polymer. Alternatively, the method includes reacting a sugar having at least two electrophilic moieties with at least two anchors, each anchor having at least one nucleophilic moiety, to form the polymer. The anchors may be lipids or peptides. The sugar-anchor polymers stabilize lipid membranes against serum proteins, dehydration, and cryopreservation.
US09446145B2	Curcumin-antibody conjugates as anti-cancer agents The invention relates to curcumin derivatives having the formula I: wherein: Z represents: H3CO A represents —CH2—CH2— or —CH═CH—; L represents —C(O)—(NH)n1—R—(NH)n2—C(O)—; R represents a saturated or unsaturated, branched or unbranched hydrocarbyl chain having a minimum of 3 carbon atoms in the chain; wherein the maximum number of carbon atoms in the chain is 24; and wherein the carbon atoms of the chain can be replaced by at least one heteroatom, wherein the heteroatoms are independently —O— or —NH2—, with the proviso that each heteroatom is separated from each other heteroatom by at least two carbon atoms; n1 and n2 independently represent 0 or 1; and Y represents an antibody that binds specifically to a target antigen of a tumor cell. The invention further relates to methods of method of inhibiting the growth of tumors in a human by administering an effective amount of the curcumin derivative, and to methods of producing the curcumin derivative.
US09446144B2	Glycopeptide and uses thereof A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also provided are monoclonal and polyclonal antibodies that recognize the glycolipopeptide of the invention, as well as uses thereof.
US09446142B2	Polymer chelator conjugates Provided herein are biocompatible polymer conjugates comprising a biologically compatible polymer covalently bound to a biologically compatible chelator moiety, which in turn are optionally bound, reversibly, to pharmacologically active metal ions. The biologically compatible polymer may comprise of modified placental tissue grafts composed of at least one membrane, capable of recruiting stem cells in vivo and in vitro.
US09446141B2	Methods of producing cancer compounds Provided herein are methods of making the compound of Formula I: and certain intermediates involved in such process.
US09446138B2	Dual acting prodrugs A prodrug is provided which includes at least two different pharmaceutically and/or diagnostically active compounds independently bound by cleavable linkers and a protein-binding moiety which is capable of binding to carrier a molecule.
US09446136B2	Modified hyaluronic acid polymer compositions and related methods The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.
US09446134B2	Stabilizing alkylglycoside compositions and methods thereof The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of a peptide, polypeptide, or variant thereof, for example octreotide or variant thereof.
US09446133B2	Dry powder inhaler and system for drug delivery A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
US09446132B2	Diether based biodegradable cationic lipids for siRNA delivery Disclosed herein are novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. The cationic lipids can demonstrate enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain coupled with inclusion of hydrolysable functionality in the lipid chains to enhance the efficiency and tolerability of in vivo delivery of siRNA.
US09446130B2	BTK inhibitors The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salts thereof. Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
US09446128B2	Composition comprising egg white combined chalcanthite for preventing or treating cancer The present invention relates to a composition comprising an egg white combined chalcanthite component for preventing or treating cancer, and more particularly, to a composition for preventing or treating cancer, which comprises egg white combined chalcanthite prepared by mixing a roasted chalcanthite with egg white to reduce the toxicity of the chalcanthite or comprises a mixture of the egg white combined chalcanthite and a bamboo salt, and a method for preparing the same. The composition comprising the egg white combined chalcanthite exhibits excellent anti-cancer activity, and thus is usefully applicable to pharmaceutical preparations for preventing or treating cancer or the manufacture of health functional foods.
US09446127B2	Compositions including androgen receptor degradation (ARD) enhancers and methods of prophylactic or therapeutic treatment of skin disorders and hair loss The present invention includes methods and compositions useful for treating and preventing skin disorders, hair loss and other skin disorders. The compositions include an ARD enhancer in combination with a second compound or composition. In some embodiments the second compound is at least one of a bactericide, an antibiotic, an anti-microbial peptide, Vitamin A, a Vitamin A derivative, a retinoid, an anti-inflammatory compound, and anti-androgen compounds.
US09446126B2	Thermal treatment of acne with coated metal nanoparticles Treatment of skin tissue with photoactive materials and light, such as nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans. In particular, embodiments of thermal treatment of acne with coated metal nanoparticles are disclosed.
US09446125B2	Anti-EphA2 antibodies and methods of use thereof Antibodies that bind to tumor associated antigen CD44 or to tumor associated antigen EphA2, are disclosed herein, as well as related compositions and methods of use. Methods of use encompass cancer therapies, diagnostics, and screening methods.
US09446122B2	Use of GK-1 peptide expressed on M13 filamentous phage as pharmaceutical ingredient to enhance the efficiency of the immune response induced by vaccine or pathogen antigens The present invention is directed to the use of FGK-1 immunopotentiator, composed by the peptide named GK-1, characterized by the sequence G-Y-Y-Y-P-S-D-P-N-T-F-Y-A-P-P-Y-S-A (SEQ ID No. 1) and linked to the pVIII surface protein of M13 filamentous phage, to prepare pharmaceutical products potentiating the protective immune response of vaccine antigens when used by itself or conjointly with these antigens administered either intranasally, subcutaneously, or intramuscularly, yielding an increase in the level of specific antibodies against vaccine antigens in serum and in bronchioalveolar lavages.
US09446121B2	Cloning of honey bee allergen The present invention relates to a recombinant polypeptide capable of binding to IgE from subjects allergic to venom of an insect from the order Hymenoptera having a homology of more than 70% to the amino acid sequence of SEQ ID NO: 2, which is the honey bee allergen Api m3 (acid phosphatase). The invention further relates to nucleic acid encoding the polypeptide, expression vectors, host cells and methods of preparing the polypeptide, as well as diagnostic and pharmaceutical uses thereof.
US09446117B2	Rotavirus subunit vaccines and methods of making and use thereof The present invention provides Rotavirus antigenic polypeptides or antigens that elicit an immune response in animal or human against rotavirus, compositions comprising said rotavirus polypeptides, methods of vaccination against rotavirus, and kits for use with such methods and compositions. The invention further provide novel expression vectors for producing the vaccine antigenic polypeptides.
US09446114B2	Cross-protective arenavirus vaccines and their method of use The invention relates to DNA vaccines that target multiple arenavirus agents singly or simultaneously.
US09446112B2	Clostridium difficile DNA vaccine The invention relates to compositions and methods for treating C. difficile associated disease (CDAD) through the administration to a subject in need thereof at least one nucleic acid encoding at least a portion of at least one of toxin A and toxin B.
US09446111B2	Inactivated bacterial cell formulation The invention relates to the use of lactic acid-producing bacteria to boost the immune system.
US09446110B2	Vaccine candidates against Johne's disease A composition and method for immunizing a mammal infected with Mycobacterium are disclosed. The genes gcpE, pstA, kdpC, papA2, impA, umaA1, fabG2_2, aceAB, mbtH2, lpqP, map0834c, cspB, lipN, and map1634 of M. paratuberculosis and the products that they encode are vaccine targets for Johne's and Crohn's disease. Eighteen M. paratuberculosis-specific genomic islands (MAPs) were identified. Three inverted large genomic fragments in M. paratuberculosis (INV) were also identified. These genomic identifiers represent novel virulence determinants that can be used as targets for vaccines and for developments of drugs against Johne's disease. The methods can be used to deliver an immunizing compound to a mammal, to provide an immune response against Johne's or Crohn's disease in the mammal.
US09446107B2	Scaffolds for cell transplantation A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
US09446104B2	Method of inducing a proinflammatory immune response to human α-lactalbumin Compositions and methods for immunization against human breast cancer are disclosed. A breast cancer vaccine comprises an immunogenic polypeptide comprising human α-lactalbumin.
US09446098B2	Composition for controlled release of physiologically active substance A composition for controlled release of a physiologically active substance can release a physiologically active substance in vivo at the desired timing. The composition includes an inner layer that is formed of a biodegradable substance that supports a physiologically active substance, and an outer layer that is formed of a biodegradable substance that differs from that of the inner layer.
US09446079B2	Honey and silver nitrate composition, composition dressing and methods of making same A composition of medical grade honey and silver nitrate is described for treatment of burns, ulcers, and open wounds. The disclosed composition is a gel of medical grade honey and silver nitrate in a ratio of about 211 to 1, with a moisture level of no greater than 20 percent and wherein the medical grade honey contains about 300 kg/mg of methylglyoxal. Also described are methods of making and using the honey and silver nitrate mixture for treatment of burns, ulcers and wounds including direct application to a treatment area as well as impregnating a gauze fabric with a composition of medical grade honey and silver nitrate for application to a treatment area.
US09446077B2	Fascia fibrous compositions and methods for their use and manufacture Embodiments of the present invention encompass fascia, fat, and dermis fibrous compositions, and methods for their manufacture and use. In a first aspect, embodiments of the present invention encompass methods for obtaining a fascia fiber for use in producing a biotextile. Exemplary methods may include treating a cadaveric fascia tissue with acetone, and obtaining the fascia fibers from the treated fascia tissue. In some cases, methods may include processing the fascia fibers to produce the fibrous fascia biotextile.
US09446075B2	Compositions derived from stem cell released molecules and methods for formulation thereof Compositions for use in treatment of a variety of tissue diseases include stem cells and stem cell released molecules (SRM's) suspended in an aqueous solution with a cellulosic material or other thickening agent. The stem cells and SRM's can be derived from one or more distinct cell lines. The SRM's can further include one or more mucins, cytokines, or growth factors. Exemplary formulations include stem cells and SRMs derived from epithelial stem cells, corneal limbal stem cells, and fibroblasts. Other compositions and methods for formulation thereof are described.
US09446072B2	Methods of ameliorating oxidative stress by increasing the efficiency of GPX and SOD activity Methods of ameliorating cellular oxidative stress are disclosed. The methods include contacting at least one cell with a composition comprising a mixture of reduced species (RS) and reactive oxygen species (ROS). The mixture of reduced species (RS) and reactive oxygen species (ROS) mirrors a target mixture where the target mixture is the reduced species (RS) and reactive oxygen species (ROS) found in a known biological system.
US09446071B2	Antimicrobially active compositions based on zinc compound, glycerine monoalkyl ether and antioxidant Antimicrobial compositions containing (i) at least one zinc compound selected from zinc salt and zinc oxide; (ii) at least one glycerine monoalkyl ether, R—O—CH2—CHOH—CH2O, wherein R is a branched or unbranched C1-C24 alkyl group that can be substituted with one or more hydroxy and/or C1-C4 alkoxy group(s) and/or the alkyl chain can be interrupted by up to four oxygen atoms; (iii) at least one antioxidant; and optionally (iv) one or more alkanediols; the weight ratio of (ii) to (iii) is at least 10:1. The compositions are used in cosmetics and pharmaceuticals and have broad anti-microbial activity, in particular against Pseudomonas aeruginosa, at active contents of only about 3 wt. %.
US09446069B2	Skin external composition comprising a sea salt and sugar as active ingredients for preventing and treating vaginosis and the use thereof A skin external composition comprising a combination of salt and sugar as an active ingredient in an amount effective to treat and prevent vaginosis, together with a pharmaceutically acceptable carrier, and the use thereof.
US09446067B2	Mercapto-modified biocompatible macromolecule derivatives with low degree of mercapto-modification and the cross-linked materials and uses thereof The present invention discloses a mercapto-modified biocompatible macromolecule derivative with a low degree of modification. The mercapto-modified biocompatible macromolecule derivative not only maintains the initial structure, physiological function and biocompatibility as much as possible, but also allows the preparation of the biocompatible macromolecule cross-linked material with a low degree of cross-linking through the effectively chemical cross-linking with the introduced mercapto group. The present invention further discloses a disulfide-bond cross-linked biocompatible macromolecule material with a very low degree of cross-linking. The disulfide-bond cross-linked biocompatible macromolecule material not only maintains the initial structure, physiological function and biocompatibility of the biocompatible macromolecule as much as possible, but also effectively prolongs turn over and reduces the solubility of the biocompatible macromolecule in vivo, better meeting the requirements of various clinical applications. The present invention further relates to the application of the disulfide-bond cross-linked biocompatible macromolecule material in the field of medicine and pharmacy.
US09446066B2	Methods for reducing pulmonary uptake of intravenously injected cells Dextran sulfate is used in order to reduce pulmonary uptake of intravenously injected Dextran sulfate is capable of reducing the pulmonary uptake of the intravenously injected cells to the levels obtained for intraarterial injection of the cells but without the accompanying risks and side effects of using intraarterial cell injection. The dextran sulfate can therefore be used in a composition together with tumor infiltrating T-lymphocytes to treat metastatic cancer in a subject.
US09446065B2	Pharmaceutical composition for use in the treatment and/or the prevention of osteoarticular diseases An intra-articular pharmaceutical composition is used for the treatment and/or the prevention of acute or chronic osteoarticular diseases and acute or chronic osteoarticular symptoms especially osteoarthritis. The composition includes a possibly adequate pharmaceutical carrier or diluent, a glycosaminoglycan, a compound activating the alpha 2 adrenergic receptor, an anti-inflammatory agent and stem cells.
US09446058B2	Pharmaceutical composition based on a hepatoprotector and a prebiotic, and production and application thereof The invention relates to medicine, hepatology and pharmacology and can be used for producing and using a pharmaceutical composition based on a hepatoprotector and a prebiotic for treating and preventing liver diseases which are caused by lipid-cholesterol exchange and selected from the following group: cholelitiasis mainly with cholesterol stones, alcoholic and non-alcoholic steatohepatitis, biliary cirrhosis, cholesterol imbibition gallbladder and drug-induced and toxic liver damage. The pharmaceutical composition is administered by mouth and contains a hepatoprotector and a prebiotic taken, as an active agent, in therapeutically effective doses. The invention contributes to the liver's functional recovery in a short time and prevents disease recidivation owing to the recovery of cholesterol exchange and intestinal biocenosis as a result of the synergistic interaction of a hepatoprotector and a prebiotic, thereby also preventing hepatoprotector side effects.
US09446056B2	Parenteral compositions of celecoxib Parenteral (injectable) celecoxib emulsions and nanoemulsions are disclosed as are their use to treat pain in patients so afflicted. The emulsions are generally oil in water emulsions often comprised of an oil phase including an oil and a lecithin wherein the mean droplet size of the discontinuous oil phase is about 200 nanometers or less.
US09446040B2	Substituted imidazoquinolines Imidazoquinolines of formula I that contain substituted amine or amide functionality at 1-position and that are effective as Toll like Receptor 7 activators are disclosed. These compounds are useful as anticancer agents.
US09446037B2	Methods for the treatment of parkinson's disease psychosis using pimavanserin Methods for the treatment of Parkinson's disease psychosis which comprise the administration of pimavanserin.
US09446035B2	1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof Provided herein are compounds according to Formula I and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancers such as colon, ovarian, pancreatic, breast, liver, prostate and hematologic cancers:
US09446034B2	Pyrazolylaminopyridines as inhibitors of FAK The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
US09446032B2	Methods for treating cardiovascular disorders There is provided a once-a-day therapeutically synergistic pharmaceutical dosage form for treatment of cardiovascular disorders, wherein the dosage form comprises a fixed dose combination of metoprolol in extended release form and one or more calcium channel blocker, angiotensin II receptor blocker or angiotensin converting enzyme inhibitor along with one or more rate controlling excipient.
US09446031B2	Compositions and methods for neovascularization The invention is directed to a method of inducing angiogenesis at a site in an individual in need thereof comprising administering locally to the site an effective amount of one or more agents that induce hypoxia induced factor 1α (HIF-1α). In another aspect, the invention is directed to a method of inducing angiogenesis at a site in an individual in need thereof comprising administering locally to the site an effective amount of one or more agents that induce hypoxia induced factor 1α (HIF-1α) and one or more lysophospholipids. In addition, the invention is directed to methods of generating prevascularized tissue, methods of generating a vascular network in a device and compositions thereof.
US09446028B2	Methods of increasing tonic inhibition and treating fragile X syndrome and angelman syndrome Methods of increasing tonic inhibition in a subject in need thereof, for example a subject with Fragile X syndrome or Angelman syndrome are disclosed. Methods of treating secondary insomnia in a subject with a neurodegenerative disease or disorder are also disclosed. The methods can include administering the subject an effective amount of 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP) or a derivative thereof, or a pharmaceutically acceptable salt thereof, increase tonic inhibition in neurons of the subject; to increase slow wave sleep (SWS) and/or slow wave activity (SWA), normalize sleep architecture, reduce secondary insomnia, increase non-rapid eye movement (NREM) sleep, increase sleep continuity, enhance delta activity within NREM, increase or improve total sleep time (TST), increase or improve sleep efficiency, reduce total time awake (TAA), reduce number of awakenings (NWA), reduce latency to persistent sleep (LPS), or to reduce wake after sleep onset (WASO), in the subject, or any combination thereof.
US09446017B2	Compositions and methods for treating herpes simplex virus Green tea polyphenol compositions and methods of their use in treating herpes simplex virus (HSV) are provided. Representative green tea polyphenols include, but are not limited to (−)-epigallocatechin-3-gallate as well as green tea polyphenols with one on more ester-linked fatty acids.
US09446016B2	Methods of treating age related disorders The invention generally relates to methods of treating a patient having, and/or at risk of, oxidative distress disorders and/or age-related disorders. The disclosure also generally relates to methods of treating memory impairment or enhancing the cognitive function of a patient in need thereof. Such methods may include administering a therapeutically effective amount of a MetAP2 inhibitor.
US09446015B2	Quinone based nitric oxide donating compounds for ophthalmic use The present invention relates to novel nitric oxide donor compounds for the use in the treatment and/or prophylaxis of hypertensive glaucoma, normotensive glaucoma and ocular hypertension.
US09446010B2	Compounds and methods for treating aberrant adrenocortical cell disorders Methods and compositions are provided for treatment of disorders associated with aberrant adrenal cortex cell behavior, including (but not limited to) treatment of adrenocortical carcinoma (ACC), Cushing's syndrome and/or pituitary ACTH excess (Cushing's Disease). Such methods involve administration of an effective amount N-(2,6-bis(1-methylethyl)phenyl)-N′-((1-(4-(dimethylamino)phenyl)cyclopentyl)-methyl)urea hydrochloride to the patient.
US09446006B2	Hydroxytyrosol combinations for enhancing mitochondrial function and energy production Hydroxytyrosol or olive juice containing hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1, B2, B3, B5, B6, and/or B12) and ginseng (preferably: root) extract.can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.
US09446002B2	Spheroids and multiparticulate tablets comprising them The invention relates to a directly-compressible gastro-resistant spheroid. The spheroid comprises: (i) a core containing one or more active substances; (ii) a flexible, deformable film which directly coats the aforementioned core and which comprises an enteric polymer and a mixture of saturated and/or unsaturated polyglycosylated glycerides, the fatty acids of which include at least 8 carbon atoms; and (iii) an outer water-dispersible layer containing at least one disintegrating agent. The invention further relates to multiparticular tablets comprising said spheroids.
US09446000B2	Cellulosic gel material as a pharmaceutical excipient A method of making a pharmaceutical tablet comprises (a) combining (i) an aqueous networked cellulose gel with (ii) filler and (iii) an active agent to form a mixture thereof; (b) casting the mixture to form a wet tablet; (c) drying the wet tablet to form a dry pharmaceutical tablet; and then (d) optionally coating the tablet (e.g., with an enteric coating). Pharmaceutical tablets produced by such methods are also described.
US09445998B2	Pharmaceutical dosage forms comprising a low-solubility drug and a polymer A dosage form comprises a low-solubility drug, and a precipitation-inhibiting polymer. The drug is in a solubility-improved form and in the form of particles at least partially coated with the precipitation-inhibiting polymer.
US09445997B2	Microcapsules comprising a fat-soluble active substance The invention relates to microcapsule comprising at least one fat-soluble active substance selected from provitamins, vitamins and esters thereof, monounsaturated fatty acids, polyunsaturated fatty acids (PUFA's), carotenoids and benzoquinones embedded in a matrix comprising a hydrocolloid and optionally one or more other matrix components, wherein the content of active substance(s) is from 30 to 60% of total weight of the microcapsule, and wherein the ratio between said fat-soluble active substance(s) and said hydrocolloid is at least 4:1, as well as a process for preparing such microcapsules.The microcapsules of the invention may be used for the preparation of tablets, food products and other products including an active substance.
US09445996B2	Extended production of nitric oxide from a microencapsulated nitrite salt and an aqueous acidified gel Methods and compositions are provided for generating and applying long-lasting therapeutic nitric oxide (NO) gas from the reaction of a least one microencapsulated nitrite salt and an activating volume of an aqueous acidified gel that has sufficient acidity to convert the nitrite salt to a nitric oxide (NO) and further provides a reducing property that retains the NO in bioactive form.
US09445995B2	Proliposomal testosterone formulations Novel testosterone formulations are disclosed where testosterone is incorporated into a phospholipid/cholesterol system to produce a proliposomal powder dispersion. The proliposomal powder dispersions of the invention may be formulated with phamarceutically acceptable excipients to form pharmaceutical compositions. Enterically coated oral dosage forms are disclosed as are methods of treatment for testosterone replacement therapy.
US09445994B2	Lipid vesicle compositions and methods of use The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
US09445992B2	Mucosal delivery compositions comprising a peptide complexed with a crown compound and/or a counter ion Compositions and methods are provided for mucosal delivery of peptides. The compositions include a stably hydrated peptide active agent complexed with a crown compound and/or a counter ion solubilized in a non-aqueous hydrophobic vehicle at a pH different from the pI of the peptide active agent. The methods include administering to a subject an effective amount of a composition of the disclosure. Other aspects include methods for the manufacture of the compositions of the disclosure. Also provided are compositions and kits that find use in practicing embodiments of the disclosure. The methods and compositions find use in a variety of applications, including the treatment of a variety of different disease conditions.
US09445989B2	Topical wound treatment method and composition A topical wound treatment composition comprises a hydrogen peroxide generator; alkaline powder; not more than 5 percent by weight of water; additional topical active agent if desired, and emollient (preferably hygroscopic emollient) to balance. When topically applied to a wound and water from the surrounding environment diffuses into the composition, the hydrogen peroxide generator and/or the alkaline compound diffuse into one another, causing a chemical reaction that generates treatment-effective amounts of oxygen to occur. The oxygen can then diffuse out of the composition and aid in wound treatment or healing.
US09445987B2	Ceramide production enhancer and moisturizer A ceramide production enhancer and a moisturizer containing, as an active ingredient, an extract of at least one plant selected from the group consisting of Chenopodium hybridum, Melia toosendan, Indigofera tinctoria, Cirsium japonicum, Catalpa ovate, and Tagetes erecta, or a compound represented by the following Formula (1): wherein, R represents an acyl group having 1 to 5 carbon atom(s).
US09445983B2	Aqueous manicure composition Provided is an aqueous manicure composition by which three-dimensional patterns and shapes can freely be formed in an one-liquid, wherein the shapes are maintained after drying, and make-up such as a nail art can easily be enjoyed. The above aqueous manicure composition is characterized by containing at least an acrylic resin emulsion, a thickener and an extender.
US09445979B2	Hair treatment composition containing gambogic acid, ester or amide The present invention relates to a cosmetic composition comprising compounds or salts of formula (I) or formula (II), wherein R1 and R2 are both independently hydrogen (H), or a saturated, straight or branched C1-C8 alkyl group. More particularly, the present invention also relates to the use of said cosmetic composition for the prevention of the graying of hair and/or for restoration and/or maintenance of the natural hair color.
US09445975B2	Composition and method for preparing stable unilamellar liposomal suspension Compositions and methods for producing and using stable transparent to translucent unilamellar liposomal suspensions are described. The suspensions include a liposome preparation having a uniform plurality of unilamellar liposomal particles with a mean particle size between about 50 nm to about 290 nm. The particles are suspended in an external phase composition that has a density between about 0.95 g/cc and about 1.25 g/cc, and that is present in an amount between about 30% to about 75% of the weight of the liposomal suspension. The liposome preparation is formed from an aqueous liposomal solution that includes an oil-soluble composition and a water-soluble composition. The oil-soluble composition is present at a concentration between about 5% to about 33% by weight of the liposomal solution and the water-soluble composition is present at a concentration between about 67% to about 95% by weight of the liposomal solution.
US09445973B2	Dental filling composition comprising zirconia powder A dental filling composition includes zirconia powder, a hydraulic inorganic binding agent, a slightly acidic hardening controller agent and a pozzolan component with respect to the gross weight of the composition. The dental filling composition includes 45% to 85% of zirconia powder with respect to the gross weight of the composition, and includes a minimum quantity of inorganic binding agent, thus exhibiting excellent radio opacity and hardly comprising heavy metals. Therefore, the dental filling composition of the present invention is excellent in biocompatibility, and therefore, can be safely and widely used in various dental filling operations.
US09445971B2	Method of manufacturing solid dosage form In one aspect, the present invention features a method of manufacturing a solid dosage form, the method including the steps of: (a) measuring an amount of a first powder blend within a dosing nozzle, wherein the first powder blend includes a pharmaceutically active agent; (b) discharging the measured amount of a first powder blend from the dosing nozzle into a forming cavity within a die block, the forming cavity having an inner wall, a first opening at the surface of one side of the die block, and a second opening at the surface on the opposite side of the die block; (c) moving a first forming tool into the forming cavity through the first opening of the forming cavity such that the first powder blend is formed into the shape of the dosage form within the forming cavity between the inner wall, the first forming tool and a second forming tool within or adjacent to the cavity; (d) applying RF energy between a first electrode and a second electrode such that the energy heats the first powder blend within the forming cavity to form the dosage form; and (e) removing the dosage form from the forming cavity.
US09445969B2	Systems and apparatus for container conversion Aspects of the present invention relate to systems, methods and apparatus for converting a container into a smart bottle. According to a first aspect of the present invention, a smart-bottle apparatus may comprise a container portion comprising a plurality of individually addressable sensor pairs covering the wall of the container portion. According to a second aspect of the present invention, a smart-bottle apparatus may comprise a container portion comprising a plurality of individually addressable sensor pairs covering a neck portion of the container portion.
US09445968B1	Infant mobility device A system for aiding the crawling mobility of children or young adults is disclosed. The system consists of central hub supported by four legs. The patient is enclosed in a harness which is coupled to a support cord extending through the central hub. A lifting force partially offsetting the patient's weight is supplied by tension on the support cord, which is locked relative to the central hub via a locking device. Coupling between the support cord and harness is provided by carabineers which are clipped to “D” rings on the harness. The balance point can be adjusted by moving the attachment point to various “D” ring locations.
US09445967B2	Automated CPR device This invention relates to an automated cardiopulmonary resuscitation device for cyclically compressing a patient's chest. The CPR device comprises a front structure with a first and a second movable unit arranged to move back and forth along said front structure; a back support for positioning behind the patient's back arranged to keep the front structure in a fixed position relative to the patient's back; a chest pad; two arms each rotatably coupled to the chest pad with one end and each being rotatably coupled to a respective one of the first and the second movable units; and a motor arranged for, when in operation, driving the first and the second movable units back and forth such that the chest pad cyclically compresses the patient's chest.
US09445965B2	Methods for treating spine pathologies A method of treating spine pathologies and related outcomes in a subject in need thereof is provided. The method includes placement of at least two calibrated, differential disturbances or protuberances under the subject's feet.
US09445963B2	Patient transfer system A patient transfer system includes a patient transfer assembly and a patient transfer device. The assembly includes a sheet of corrugatable material, at least one stiffener that resists corrugation of the sheet in a first dimension when the patient transfer assembly including the sheet corrugated in a second dimension is inserted between the patient and a surface of a first resting device on which the patient rests. The sheet includes portions at which pulling in a direction along the second dimension decorrugates the sheet between the patient and the surface and fasteners. The device includes a sheet engaging assembly that pulls at least one of the fasteners in a direction along the first dimension to slide the decorrugated sheet relative to the surface thereby transferring the patient.
US09445960B2	Stair-climbing wheelchair A stair-climbing wheelchair comprising deformable main rear wheels comprising lockable suspension elements and front supporting wheels comprising lockable suspension elements is disclosed herein. The wheelchair may operate in at least two modes, a standard mode and a stairs mode. In standard mode, the wheelchair may operate similar to an ordinary basic wheelchair, with suspension elements locked and rigid. In stairs mode, the suspension elements may be activated and the rear wheels may be deformable to readily negotiate an uneven surface, wherein the front suspension elements may be elongated to provide balance while climbing. The operating principles behind the functionality of the device disclosed herein may also be applied to other devices used to negotiate stairs, such as devices used to move heavy appliances on stairs.
US09445958B2	Manual wheelchair system for improved propulsion and transfers A manual wheelchair including a frame, a drive wheel connected to the frame, having a first axis of rotation and configured to rotate relative to the frame, a push rim connected to the frame, having a second axis of rotation extending substantially parallel to the first axis of rotation of the drive wheel and configured to rotate relative to the frame, wherein the second axis of rotation of the push rim is offset from the first axis of rotation of the drive wheel in a direction orthogonal to the first axis of rotation of the drive wheel, and a transmission configured to transmit rotation of the push rim to rotation of the drive wheel. Additionally, the wheelchair may also include multispeed fixed-gear hubs for propulsion on different terrain and removable or rotatable push rims for easier transfers.
US09445954B2	Absorbent article with a fluid-entangled body facing material including a plurality of hollow projections An absorbent article having improved handling of body exudates can include a fluid-entangled body facing material including a support layer and a projection layer. The fluid-entangled body facing material can include a plurality of hollow projections formed from a first plurality of fibers in the projection layer. The hollow projections can extend from the outer surface of the projection layer in a direction away from the support layer. The absorbent article can minimize the amount of body exudates in contact with a wearer's skin and can minimize the incidence of leakage of body exudates from the absorbent article.
US09445949B1	System and method for processing commands in an online game One aspect of the disclosure relates to processing commands in an online game, and particularly for assigning an order for the execution of commands in the online game such that the commands are executed in that order by disparate servers. The online game may be played by a plurality of users via a respective plurality of client computing devices. Commands may be received at a plurality of game servers from a plurality of users via a plurality of client computing devices. A central server may receive the commands from the respective game servers and may assign sequence numbers for the received commands. The commands may be performed in sequential order. By executing commands in sequential order by the plurality of game servers, the virtual world of the online game may be presented in a consistent way to the plurality of users of the online game.
US09445946B2	Laser eye surgery system A laser eye surgery system includes a laser source, a ranging subsystem, an integrated optical subsystem, and a patient interface assembly. The laser source produces a treatment beam that includes a plurality of laser pulses. The ranging subsystem produces a source beam used to locate one or more structures of an eye. The ranging subsystem includes an optical coherence tomography (OCT) pickoff assembly that includes a first optical wedge and a second optical wedge separated from the first optical wedge. The OCT pickoff assembly is configured to divide an OCT source beam into a sample beam and a reference beam. The integrated optical subsystem is used to scan the treatment beam and the sample beam. The patient interface assembly couples the eye with the integrated optical subsystem so as to constrain the eye relative to the integrated optical subsystem.
US09445945B2	Steerable laser probe A steerable laser probe may include a handle having a handle distal end and a handle proximal end, an actuation control of the handle, a flexible housing tube having a flexible housing tube distal end and a flexible housing tube proximal end, an optic fiber disposed within an inner portion of the handle and the flexible housing tube, and a cable disposed within the flexible housing tube and the actuation control. A rotation of the actuation control may be configured to gradually curve the flexible housing tube and the optic fiber. A rotation of the actuation control may be configured to gradually straighten the flexible housing tube and the optic fiber.
US09445941B2	Bioresorbable drug eluting intravitreal implant system and method A bioresorbable drug eluting intravitreal implant system includes a syringe with a chamber containing a medicinal drug. A balloon is releasably secured to a needle where the needle has a central section chamber in fluid communication with a chamber in the syringe. The needle central section has an opening formed through a wall for transporting the medicinal drug to the interior of the balloon subsequent to insertion of the needle through the sclera of a patient's eye.
US09445940B2	System and method for inducing hypothermia with control and determination of catheter pressure Embodiments of the invention provide a system for temperature control of the human body. The system includes an indwelling catheter with a tip-mounted heat transfer element. The catheter is fluidically coupled to a console that provides a heated or cooled heat transfer working fluid to exchange heat with the heat transfer element, thereby heating or cooling blood. The heated or cooled blood then heats or cools the patient's body or a selected portion thereof. In particular, methods and devices are provided for control and determination of the pressure within the heat transfer element.
US09445939B2	Eye treatment compress A method of providing moisture therapy to a subject by applying a moist therapy compress against a treated body portion. The moist therapy compress includes a fluid-permeable shell, a flexible backing fastened to the shell to define an enclosure, and a hydrophilic zeolite fill granules loosely contained within the enclosure. The therapy compress is exposed to a source of moisture to cause absorption of water into the a hydrophilic zeolite, and the moisture is delivered from the hydrophilic zeolite through the fluid permeable shell to the treated body portion.
US09445936B2	Method of treating snoring and obstructive sleep apnea A method, system and device for addressing the reduction of snoring includes a removable or dissolvable strip of material that adhere to mucosal tissue of a person's soft palate to provide stiffening support therefore, thus reducing the occurrence of vibration of such tissue during sleep. Preferred embodiments include of a specially textured surface, either one both or at least the outer side of an adhesive strip (the side facing away from the mucosal tissue to which it is attached) that has anti-microbial characteristics, bioluminescent expressions, etc. and a surface topography that resists bioadhesion of undesired bacteria that are typically present in a human's mouth.

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