| Document | Document Title |
|---|---|
| US08947019B2 |
Handheld device and power supply circuit thereof
A handheld device includes a backlight driving unit and a power supply circuit for powering the backlight driving unit. The power supply circuit includes a power management unit, a battery, a first electronic switch, a second electronic switch, and a control unit. When a voltage of a second terminal of the second electronic switch is less than a reference voltage of the control unit, the control unit turns on the first electronic switch and turns off the second electronic switch. The backlight driving unit is powered by the battery through the first electronic switch. When the voltage of the second terminal of the second electronic switch is more than the reference voltage of the control unit, the control unit turns off the first electronic switch and turns on the second electronic switch. The backlight driving unit is powered by the PMU through the second electronic switch. |
| US08947018B2 |
Dimmable LED driver and method for controlling the same
A dimmable LED driver adapted to be operated with a dimmer that is configured to generate a predetermined conductive angle, wherein the dimmable LED driver comprises: a rectifier configured to convert an alternating current output by the dimmer to a direct current, a buck PFC block configured to adjust an output voltage of the direct current so as to obtain a stable output voltage, a second buck DC/DC block configured to realize output of a constant current after the stable output voltage is realized, a dimming block configured to, after realizing output of the constant current, accomplish a dimming function jointly with the second buck DC/DC block, and an MCU configured to control the buck PFC block, the second buck DC/DC block and the dimming block. |
| US08947017B2 |
Semiconductor light source lighting circuit
A circuit for lighting a semiconductor light source is provided. The circuit includes: a switching regulator including a switching element and configured to generate a drive current for the semiconductor light source using the switching element; and a control circuit configured to control on-off of the switching element such that the magnitude of the drive current comes close to a targeted value. The control circuit includes: a comparator configured to compare the magnitude of the drive current with the targeted value; an up/down counter configured to count a digital value in a counting-up direction or counting-down direction, based on a comparison result of the comparator; a digital-to-analog converter configured to convert the counted digital value into an analog signal; and a drive circuit configured to control on/off of the switching element based on the analog signal. |
| US08947006B2 |
Multi-mode control circuit for light-emitting shoe
A multi-mode control circuit for light-emitting shoe, comprising a control circuit, wherein the control circuit comprises a microprocessor-encapsulated circuit board and a motion actuated switch, the motion actuated switch is at least provided with two trigger circuits, the first trigger circuit can trigger the control circuit in response to the motion of a shoe body, so that light-emitting bodies light in a predetermined way, and the second trigger circuit is used for activating a circuit-predetermined control mode, the predetermined control mode is that, a power supply control switch of the circuit is activated, or the light-emitting bodies are activated to light in the Nth predetermined way when the second trigger circuit performs the Nth triggering, wherein N is a natural number larger than or equal to 1, and the value of N, when being equal to the total number of the predetermined ways plus 1, is reset to 1. |
| US08947005B2 |
Programmable lighting device
A flashlight (1) having a control unit (4) with a push button (12) for activating the flashlight (1). The control unit (4) connects to a computer via USB port, whereby user-configurable control information is downloaded. A computer program running on the computer enables operating conditions of the flashlight to be selected by a user according to predetermined types of activation e.g. of the push button (12). The operating conditions are collated into operating instructions associated with the predetermined types of activation. The operating instructions are converted into byte code and downloaded to and stored on a memory in the control unit (4). Upon detecting a predetermined activation type, the control unit accesses the operating conditions and configures the flashlight accordingly. |
| US08947003B2 |
Circuit and method for independent control of series connected light emitting diodes
Described herein is a circuit and method for independent control of series connected light emitting diodes (LEDs). The circuit includes a first light emitting diode (LED) connected in series with a second LED. A current source is connected in series with the first LED and the second LED and a shunt circuit is connected in parallel with the first LED and the second LED. The shunt circuit includes a pair of serially connected resistors. The shunt circuit prevents inadvertent excitement of the LEDs due to leakage currents but minimally affect illumination characteristics of the LEDs. A pair of transistors is connected to the first LED and the second LED, respectively, and is biased using a set of bias resistors. A tri-state control signal switches on and off the pair of transistors and enables excitation of the first LED, the second LED or both via the current source. |
| US08947000B2 |
Microcontroller-based multifunctional electronic switch
A microcontroller-based multifunctional electronic switch using a detection circuit design to convert external motion signals into message carrying sensing signals readable to the microcontroller. Based on the time length of sensing signals and the format of the sensing signals received in a preset instant period of time the microcontroller through the operation of its software program codes written in the OTPROM is able to recognize the working modes chosen by the external signal generating user and thereby selecting the appropriate loops of subroutine for execution. The system and method of the present invention may simultaneously be applicable to detection circuit design using infrared ray sensor, electrostatic induction sensor, conduction based touch sensor or push button sensor for performing multifunction such as controlling the on/off switch performance, the dimming or speed control and the delay timer management within the capacity of a single lighting device or an electrical appliance. |
| US08946995B2 |
LED driver circuit
A semiconductor chip includes an LED driver circuit operably coupled to at least one LED and configured to supply a load current to the at least one LED such that an average load current matches a desired current level defined by a drive signal. A temperature measurement circuit is thermally coupled to the LED driver circuit or the LED(s) or both, and is configured to generate, as drive signal, a temperature dependent signal in such a manner that the drive signal is approximately at a higher constant level for temperatures below a first temperature, is approximately at a lower constant level for temperatures above a second temperature but below a maximum temperature, and continuously drops from the higher constant level to the lower constant level for temperatures rising from the first temperature to the second temperature. |
| US08946991B2 |
Apparatus, method, and system for event and backup lighting
An apparatus, system, and method for solid state lighting is envisioned which, according to aspects of the invention, provides primary event and/or utility lighting during normal power conditions, and which, during periods of interrupted power, provides uninterrupted event lighting for a desired duration, provides a gradual transition from event lighting levels to utility lighting levels, and provides a gradual transition from utility lighting levels to emergency lighting levels. |
| US08946987B2 |
Light emitting device and fabricating method thereof
A light emitting device and a fabricating method thereof are described, wherein the light emitting device includes a substrate, a wall, a first LED chip and a light conversion filling. The first LED chip is disposed on a surface of the substrate. The wall is disposed on the surface of the substrate, and surrounds the first LED chip. A first angle between a central axis of the wall and an inner surface of the wall is 0 degree or is acute, a second angle between the central axis of the wall and an outer surface of the wall is 0 degree or is acute, and the outer surface of the wall and the substrate has a space therebetween. The light conversion filling is surrounded by the light conversion wall, and is disposed on the first LED chip. |
| US08946981B2 |
Phosphor, lighting fixture, and image display device
A phosphor substituting the conventional sialon phosphor or oxide phosphor activated by rare earth and an application thereof are provided. The phosphor of the present invention comprises an inorganic crystal including at least La, Si, Al, N (nitrogen), M element (M is at least one kind of element selected from the group consisting of Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm and Yb), and O (oxygen) if necessary and the inorganic crystal is a host crystal, which is LaSi9Al19N32 crystal or a solid-solution crystal thereof, activated by the M element. |
| US08946972B2 |
Layer switching for an ultrasound transducer array
A multi-layer transducer operates with only one system channel per element. Passive switching connects the layers differently for transmit than for receive operation, such as connecting two layers in parallel for transmit and in series for receive. Any passive switching may be used, such as current and voltage limiting circuits. Tuning may be passively switched. Different tuning circuits are passively switched as a function of voltage level between transmit and receive operations. |
| US08946971B2 |
Actuator
The present invention provides an actuator which uses a cationically conductive polymer electrolyte and shows a large deformation response. The actuator has a pair of opposing electrodes and an intermediate layer arranged between the pair of the electrodes, which actuator being curved and displaced when voltage is applied to the electrodes, wherein the intermediate layer has at least: the cationically conductive polymer electrolyte having an ether bond site and an anion site in its molecule; and a weakly acidic material which interacts with the ether bond site. |
| US08946965B2 |
Armature of electric motor and electric motor
An armature of an electric motor includes a core and a winding. The core has a plurality of slots and a plurality of teeth formed between the slots. The winding is composed of a plurality of wires. The winding has a plurality of coil parts and connecting portions. The coil parts are inserted into the slots and wound around and across the teeth. The connecting portions connect the coil parts together. The winding has a twisted shape in the connecting portions. |
| US08946963B2 |
Polyphase stator for internally ventilated rotating electrical machine, and rotating electrical machine comprising such stator
A polyphase stator for an internally ventilated rotating electrical machine comprises a body (14) provided with slots and carrying a coil (12) having at least one winding per phase. A plurality of pairs of lateral branches are mounted in a slot of the body (14). A plurality of connecting heads (50 to 55) extend outside the body (14) so as to form a first lead-out (42) and interconnect each pair of lateral branches. A plurality of coupling feet (150 to 155) are offset circumferentially with respect to the plurality of connecting heads and extend outside the body (14) so as to form a second lead-out (43) and interconnect each pair of lateral branches. One of the pluralities has a generally pointed shape and has an axial length of between 15 and 20 mm. The stator is used with an alternator or alternator-stator for a motor vehicle. An internally ventilated electrical machine is equipped with the stator. |
| US08946960B2 |
Electric motor assembly
An axial flux electric motor is disclosed. The motor includes a rotor having a first rotor face, a second rotor face, a primary bearing locator on the first rotor face and one or more permanent magnets mounted to the first rotor face. Also included is a stator having a first stator face, a second stator face, a secondary bearing locator on the first stator face, a stator winding having one or more conductors and a connector for connection of the stator winding to a power source. A bearing assembly is also provided and positioned between the first face of the rotor and the first face of the stator for rotationally supporting movement of the rotor relative to the stator, the bearing assembly axially displacing the rotor from the stator to provide an air gap therebetween. The bearing assembly is engaged by the primary and secondary bearing locators to correctly position the bearing assembly. |
| US08946958B2 |
Energy storage system comprising a flywheel
An energy storage system is generally disclosed. An example system includes a flywheel having a substantially cylindrical flywheel portion, and a housing defining a substantially cylindrical cavity configured so as to receive the substantially cylindrical flywheel portion. The flywheel is rotatable in the cavity about a central axis of the flywheel, and an energy exchange device is configured to convert between electrical energy and kinetic energy associated with rotation of the flywheel. The system may also have a magnetic restraint arranged to exert a magnetic restraining force on the flywheel in a direction towards the central axis. |
| US08946954B2 |
Integrated direct drive motor and control
An outer rotor motor is provided for use in a machine. The motor includes a rotor and a stator. A control board assembly configured to control at least one operational characteristic of the motor is mounted at least in part radially inside the stator. |
| US08946951B2 |
Fan module
A fan (20) comprises a fan hub (22), fan blades (24) which are mounted on the fan hub (22), and a drive motor having an outer rotor (30), wherein the outer rotor (30) is arranged inside the fan hub (22). The outer rotor (30) is arranged in the fan hub (22) in such a way that the outer rotor (30) is supported in a radially outward direction on the radial outer wall (36) of the fan hub (22), by means of cooling fins (32) which are formed integrally with the fan hub (22). |
| US08946950B2 |
Pulling plate for spindle motor and spindle motor having the same
There is provided a pulling plate for a spindle motor, the pulling plate including: a body having a circular ring shape; and a plastic deformation part protruding upwardly from the body and plastically deformed when being mounted. Since the pulling plate is installed in the base member by deforming the plating deformation part, a coupling strength between the pulling plate and the base member may be improved. In addition, since the pulling plate may be installed in the base member only through the deformation of the plastic deformation part, an amount of deformation may be reduced. Further, contamination generated in the case that the puling plate clips the base member may be reduced as compared to a case in which the entire pulling plate is press-fitted into the base member. |
| US08946947B2 |
Electromagnetic linear stepper motor
A linear stepper motor is used for the displacement of an armature parallel to a stator having N steps. The stator includes (N+2) stator pole pieces which are enclosed by a magnetic guiding element and are each approximately the same distance from neighboring stator pole pieces. Furthermore, at least one coil is located between two stator pole pieces. The armature is enclosed by the stator in the radial direction and has a permanent magnet magnetized parallel to the stator which is disposed between two armature pole pieces. As a result of the reluctance forces, the armature occupies stable idle positions inside the stator in which the stator pole pieces lie opposite the armature pole pieces. By energizing the coils with a short current pulse, the armature can be displaced inside the stator between the different stable idle positions. |
| US08946946B2 |
Converter device and method for converting electrical power
A converter device (for power conversion in e.g. a power plant such as a wind turbine is disclosed. An individual controller is provided for each phase of an electrical output power of the converter. If a voltage of one phase is indicated as being out of a predetermined voltage band, an active current of this phase is set to zero and optionally a reactive component of this phase is set to a value that depends on the indicated voltage. |
| US08946944B2 |
Toggle switch and variable actuator control
The present invention is directed to a device for regulating an amount of electrical power provided to at least one electrical load, the device comprising a control circuit disposed in the housing and including at least one switch device movable between a first switch state and a second switch state. The control circuit further includes a power control element that has a power control actuator configured to adjust the amount of power provided to the at least one electrical load. A variable control actuator is accessible to the user via the control aperture and coupled to the power control actuator via a linkage structure. The linkage structure further includes a pin and channel arrangement configured to convert a user control action into a power control actuator adjustment by translating rotational motion into linear motion or linear motion into rotational motion. |
| US08946940B2 |
Wireless power transmission system, and method for controlling wireless power transmission and wireless power reception
A wireless power transmission system, and a method for controlling wireless power transmission and wireless power reception are provided. According to an aspect, a method for controlling a wireless power transmission may include: detecting a plurality of target devices used to wirelessly receive power; selecting a source resonating unit from among a plurality of source resonating units, based on the amount of power to be transmitted to one or more of the plurality of target devices, a coupling factor associated with one or more of the plurality of target devices, or both; and wirelessly transmitting power to a target device using the selected source resonating unit. |
| US08946939B2 |
Systems and methods for detecting and protecting a wireless power communication device in a wireless power system
Embodiments are directed to detecting and limiting power transfer to communication device, such as NFC and RFID cards. A method may include detecting one or more communication devices positioned within a wireless power transfer region of a wireless power transmitter. The method may further include limiting an amount of power transmitted by a transmitter in response to the detection. |
| US08946937B2 |
Switching circuits for extracting power from an electric power source and associated methods
An integrated circuit chip includes a first input port, a first output port, and first and second transistors electrically coupled in series across the first input port. The second transistor is also electrically coupled across the first output port and is adapted to provide a path for current flowing through the first output port when the first transistor is in its non-conductive state. The integrated circuit chip additionally includes first driver circuitry for driving gates of the first and second transistors to cause the transistors to switch between their conductive and non-conductive states. The integrated circuit chip further includes first controller circuitry for controlling the first driver circuitry such that the first and second transistors switch between their conductive and non-conductive states to at least substantially maximize an amount of electric power extracted from an electric power source electrically coupled to the first input port. |
| US08946931B2 |
Dual boost converter for UPS system
A power converter includes a power conversion circuit switchably coupled to a first power input and a second power input. The power conversion circuit is operable to generate positive and negative DC output voltages and is configured such that, in a backup mode of operation, the negative DC output voltage is generated using backup power through a first current path of the power conversion circuit that includes a first diode coupled between the second power input and a second DC bus, and, in a line mode of operation, the negative DC output voltage is generated using AC input power through a second current path of the power conversion circuit that bypasses the first diode and includes a second diode coupled between the first power input and the second DC bus. |
| US08946926B2 |
Electrical supply and starting system for a motor vehicle and method for operating the electrical supply and starting system
An electrical supply and starting system for a motor vehicle has a variable-voltage on-board electrical system that can be operated by two different DC voltages for supplying the motor vehicle, and having a motor/generator system that operates as a generator to deliver electrical energy to the on-board electrical system of the motor vehicle, and operates for starting an internal combustion engine of the motor vehicle. |
| US08946925B2 |
Operating module for an anti-theft lock and associated anti-theft lock
The invention relates to an operating module for a vehicle anti-theft lock comprising a stator and a rotor that can be turned in the stator by a conforming key comprising an electronic identifier, the said module comprising a support (3) intended to be mounted on the stator and carrying an antenna (5) intended to be connected to an identification unit capable of authenticating the electronic identifier of the said key by exchanging signals, and authorizing the starting of the vehicle when an authorized identifier has been detected. According to the invention, the said support (3) further carries at least one contactless switch (7A, 7B) that can be switched by the rotor when the rotor is turned. The invention also relates to a vehicle anti-theft lock comprising a stator and a rotor that can be turned in the stator and comprising an operating module according to the invention. |
| US08946924B2 |
Load control system that operates in an energy-savings mode when an electric vehicle charger is charging a vehicle
A load control system for a building having a lighting load, a window, a heating and cooling system, and an electric vehicle charger for charging a vehicle (e.g., an electric or hybrid vehicle) operates in an energy-savings mode to reduce the total power consumption of the load control system when the vehicle charger is presently charging the vehicle. The load control system may comprise a lighting control device for controlling the intensity of the lighting load, a daylight control device for adjusting the amount of natural light admitted through the window, and a temperature control device for controlling a setpoint temperature of the heating and cooling system to thus control a present temperature in the building. When the vehicle charger is presently charging the vehicle, the load control system automatically controls the lighting control device, the daylight control device, and the temperature control device to decrease the total power consumption of the load control system. |
| US08946922B1 |
Reverse flow hydroelectric generator
A reverse flow hydro electric turbine electrical generating system is present. It is labeled “reverse flow” in that the flow of the water driving the turbine is flowing against the force of gravity or, essentially up hill. The turbine system is comprised of a penstock for the intake of a flow of water current (as in a river or ocean stream) disposed at a depth equaling from about one atmosphere of pressure to as much as eight or more atmospheres. An amount of air is injected into the stream entering the penstock to about saturate to slightly supersaturate the solution, from which it enters a venturi-type reducer and then is piped upwardly to the turbine assembly. Attached to the top of the turbine assembly is a stand of relief pipes to carry the exhausting water to the surface for discharge. |
| US08946921B2 |
Pressure powered impeller system and related method of use
This invention is directed to a system that generates a sufficient level of electricity through access to a municipal water supply line to run a furnace during below freezing temperatures. The system includes an inlet that draws water from a water supply line. A first conduit, in communication with the inlet, transports the water into a DC generator that includes an impeller to generate electricity. Water is then routed through a second conduit which then returns the water to the water supply line through an outlet. A solenoid valve may be positioned between the inlet and first conduit which remains closed when the electric grid runs normally but will open during a power outage to supply water to the DC generator. A lithium battery stores power created by the DC generator, which may include a voltage regulator and inverter to convert to DC. |
| US08946920B2 |
Linear faraday induction generator for the generation of electrical power from ocean wave kinetic energy and arrangements thereof
Various embodiments of linear electric generators and arrangements thereof are disclosed. One such generator includes a permanent magnetic array with magnets that are oriented such that like poles of the magnets are disposed adjacently to concentrate a magnetic field through a coil array. To enhance the magnetic field distribution, the magnets are affixed under a compressive strain due to repulsive forces resulting from proximity of the like poles. According to another aspect, a plurality of vibrational linear electric generators (VLEGs) can be arranged so that magnets of different VLEGs are oriented so that poles of opposite polarity are disposed adjacently to further enhance magnetic field concentration through coil arrays. In addition, a plurality of wave energy converters can be arranged in very close proximity, at most 8 times a height of a buoyant portion of the converters, to act as a seawall and thereby protect various structures from ocean waves. |
| US08946916B2 |
Controlling a wind turbine to stabilize an electric grid
A variable speed wind turbine is configured to provide additional electrical power to counteract non-periodic disturbances in an electrical grid. A controller monitors events indicating a need to increase the electrical output power from the wind turbine to the electrical grid. The controller is configured to control the wind turbine as follows: after an indicating event has been detected, the wind turbine enters an overproduction period in which the electrical output power is increased, wherein the additional electrical output power is taken from kinetic energy stored in the rotor and without changing the operation of the wind turbine to a more efficient working point. When the rotational speed of the rotor reaches a minimum value, the wind turbine enters a recovery period to re-accelerate the rotor to the nominal rotational speed while further contributing to the stability of the electrical grid by outputting at least a predetermined minimum electrical power. |
| US08946915B2 |
Adaptive variable speed genset control
A method of determining an optimal operating speed of a variable speed genset is provided. The method may include determining whether an actual operating speed of the genset approximates a desired operating speed, the desired operating speed being predetermined based on a measured load value associated with the genset, the desired operating speed being associated with an applied offset value that is adjustable between a minimum offset value and a maximum offset value; incrementing the applied offset value of the desired operating speed to decrease the actual operating speed if the actual operating speed approximates the desired operating speed, and the applied offset value is less than the maximum offset value; and determining the desired operating speed as the optimal operating speed if the actual operating speed approximates the desired operating speed, and the applied offset value is equal to the maximum offset value. |
| US08946913B2 |
Short and low loop wire bonding
A multi-die package includes a first semiconductor die and a second semiconductor die each having an upper surface with a plurality of bond pads disposed thereon. The upper surface of the second semiconductor die may be substantially coextensive with the upper surface of the first semiconductor die and extend substantially along a plane. The multi-die package also includes a plurality of bonding wires each coupling one of the bond pads on the upper surface of the first semiconductor die to a corresponding one of the bond pads on the upper surface of the second semiconductor die. A bonding wire of the plurality of bonding wires has a kink disposed at a height above the plane, a first hump disposed between the first semiconductor die and the kink, and a second hump disposed between the second semiconductor die and the kink. |
| US08946912B2 |
Active area bonding compatible high current structures
A semiconductor structure comprises a top metal layer, a bond pad formed on the top metal layer, a conductor formed below the top metal layer, and an insulation layer separating the conductor from the top metal layer. The top metal layer includes a sub-layer of relatively stiff material compared to the remaining portion of the top metal layer. The sub-layer of relatively stiff material is configured to distribute stresses over the insulation layer to reduce cracking in the insulation layer. |
| US08946908B2 |
Dual-metal self-aligned wires and vias
Disclosed is a semiconductor structure which includes a semiconductor substrate and a wiring layer on the semiconductor substrate. The wiring layer includes a plurality of fin-like structures comprising a first metal; a first layer of a second metal on each of the plurality of fin-like structures wherein the first metal is different from the second metal, the first layer of the second metal having a height less than each of the plurality of fin-like structures; and an interlayer dielectric (ILD) covering the plurality of fin-like structures and the first layer of the second metal except for exposed edges of the plurality of fin-like structures at predetermined locations, and at locations other than the predetermined locations, the height of the plurality of fin-like structures has been reduced so as to be covered by the ILD. |
| US08946904B2 |
Substrate vias for heat removal from semiconductor die
A substrate comprising a plurality of layers, a first side and a second side; and a via extending through the substrate from the first side to the second side. The via comprises:a first substrate via extending through a first layer of the plurality of layers, the first substrate via having a first cross-sectional area; a first capture pad disposed under the first substrate via, wherein the first capture pad physically contacts the first substrate via; a second substrate via extending through a second layer of the plurality of layers, the second substrate via physically contacting the first capture pad, the second substrate via having a second cross-sectional area that is greater than the first cross-sectional area; and a second thermal and electrical contact pad disposed under the second dielectric layer, wherein the second contact pad physically contacts the second substrate via. |
| US08946903B2 |
Electrically conductive laminate structure containing graphene region
Some embodiments include electrical interconnects. The interconnects may contain laminate structures having a graphene region sandwiched between non-graphene regions. In some embodiments the graphene and non-graphene regions may be nested within one another. In some embodiments an electrically insulative material may be over an upper surface of the laminate structure, and an opening may extend through the insulative material to a portion of the laminate structure. Electrically conductive material may be within the opening and in electrical contact with at least one of the non-graphene regions of the laminate structure. Some embodiments include methods of forming electrical interconnects in which non-graphene material and graphene are alternately formed within a trench to form nested non-graphene and graphene regions. |
| US08946901B2 |
Microelectronic package and method of manufacture thereof
A microelectronic assembly may include a substrate having an opening extending between first and second oppositely facing surfaces of the substrate, the opening elongated in a first direction; and at least one microelectronic element having a front face facing and attached to the first surface of the substrate and a plurality of contacts at the front face overlying the opening, the microelectronic element having first and second opposite peripheral edges extending away from the front face. The first peripheral edge extends beyond, or is aligned in the first direction with, an inner edge of the opening, and the opening extends beyond the second peripheral edge. |
| US08946898B2 |
Semiconductor apparatus, method of manufacturing semiconductor apparatus, method of designing semiconductor apparatus, and electronic apparatus
A semiconductor device including a first material layer adjacent to a second material layer, a first via passing through the first material layer and extending into the second material layer, and a second via extending into the first material layer, where along a common cross section parallel to an interface between the two material layers, the first via has a cross section larger than that of the second via. |
| US08946897B2 |
Semiconductor device having metal lines with slits
A semiconductor device including a semiconductor substrate, an integrated circuit on the semiconductor substrate, an insulation layer covering the integrated circuit, and a plurality of metal line patterns on the insulation layer. First and second adjacent metal line patterns of the plurality of metal line patterns are spaced apart from each other by a space, and each of the first and second adjacent metal line patterns has at least one slit. |
| US08946886B1 |
Shielded electronic component package and method
An electronic component package includes a substrate having a first surface, an electronic component mounted to the substrate, traces on the first surface, a terminal on the first surface, and a solder mask on the first surface. The solder mask includes a solder mask opening exposing the terminal. An electrically conductive coating and/or conductive coating feature is formed on the solder mask and extends into the solder mask opening to contact and be electrically connected to the terminal. The conductive coating may be grounded to shield the electronic component from electromagnetic interference (EMI). Further, the conductive coating provides a ground plane for the traces facilitating impedance matching of signals on the traces. In addition, the conductive coating has a high thermal conductivity thus enhancing heat dissipation from the electronic component. The conductive coating feature can be used as a conductive path to transmit electrical signals and/or to form circuit patterns that can be used as passive devices. |
| US08946881B2 |
High-voltage packaged device
Packaged devices and methods for making and using the same are described. The packaged devices contain one or more circuit components, such as a die, that is attached to a leadframe having a first lead, a second lead, and a third lead (although, higher lead counts may be employed in some implementations). A portion of the circuit component and the leadframe are encapsulated in a molded housing so that the first lead is exposed from a first end of the housing while the second and third leads are exposed from a second end of the housing. In some configurations, the packaged device does not contain a fourth lead that is both electrically connected to the first lead and that is exposed from the second end of the molded housing. In other configurations, an area extending from the second lead to the third lead in the molded housing comprises an insulating material having a substantially uniform conductivity. Thus, the packaged devices have relatively large creepage and clearance distances between the first lead and the second and third leads. As a result, the packaged devices are able to operate at relatively high operating voltages without experiencing voltage breakdown. Other embodiments are described. |
| US08946879B2 |
Packages and methods for 3D integration including two stacked dies with a portion of one die extending into a hole of the other die
Packages and methods for 3D integration are disclosed. In various embodiments, a first integrated device die having a hole is attached to a package substrate. A second integrated device die can be stacked on top of the first integrated device die. At least a portion of the second integrated device die can extend into the hole of the first integrated device die. By stacking the two dies such that the portion of the second integrated device die extends into the hole, the overall package height can advantageously be reduced. |
| US08946876B2 |
Semiconductor device
A gate electrode (4) and a source electrode (5) of a semiconductor chip (3) are connected to a gate terminal (7) and a source terminal (9), respectively, via electric conductors (11a and 11b). A portion of the gate terminal (7) which portion is joined to the electric conductor (11a) is close to the gate electrode (4), and a portion of the source terminal (9) which portion is joined to the electric conductor (11b) is close to the source electrode (5). |
| US08946873B2 |
Redistribution structures for microfeature workpieces
Microfeature dies with redistribution structures that reduce or eliminate line interference are disclosed. The microfeature dies can include a substrate having a bond site and integrated circuitry electrically connected to the bond site. The microfeature dies can also include and a redistribution structure coupled to the substrate. The redistribution structure can include an external contact site configured to receive an electric coupler, a conductive line that is electrically connected to the external contact site and the bond site, and a conductive shield that at least partially surrounds the conductive line. |
| US08946872B2 |
Method for producing a semiconductor
A method for producing a semiconductor includes providing a p-doped semiconductor body having a first side and a second side; implanting protons into the semiconductor body via the first side to a target depth of the semiconductor body; bonding the first side of the semiconductor body to a carrier substrate; forming an n-doped zone in the semiconductor body by heating the semiconductor body such that a pn junction arises in the semiconductor body; and removing the second side of the semiconductor body at least as far as a space charge zone spanned at the pn junction. |
| US08946871B2 |
Thermal improvement of integrated circuit packages
An integrated circuit package comprising an active semiconductor device layer and at least one heat-transfer semiconductor layer on the active semiconductor device layer. The heat-transfer semiconductor layer has a coefficient of thermal expansion that substantially matches a coefficient of thermal expansion of the active semiconductor device layer. |
| US08946867B2 |
Semiconductor component with optimized edge termination
A semiconductor component includes a two-sided semiconductor body, an inner zone with a basic doping of a first conduction type, and two semiconductor zones. The first zone, disposed between the first side and inner zone, is of the first conduction type with a doping concentration higher than that of the inner zone. The second zone, disposed between the second side and inner zone, is of a second conduction type complementary to the first type with a doping concentration higher than that of the inner zone. At least one first edge chamfer extends at a first angle to the extension plane of the transition from the second zone to the inner zone at least along the edge of the second zone and inner zone.At least one buried zone of the second conduction type is provided between the first zone and inner zone, and extends substantially parallel to the first zone. |
| US08946866B2 |
Microelectronic substrate having removable edge extension element
An article including a microelectronic substrate is provided as an article usable during the processing of the microelectronic substrate. Such article includes a microelectronic substrate having a front surface, a rear surface opposite the front surface and a peripheral edge at boundaries of the front and rear surfaces. The front surface is a major surface of the article. A removable annular edge extension element having a front surface, a rear surface and an inner edge extending between the front and rear surfaces has the inner edge joined to the peripheral edge of the microelectronic substrate. In such way, a continuous surface is formed which includes the front surface of the edge extension element extending laterally from the peripheral edge of the microelectronic substrate and the front surface of the microelectronic substrate, the continuous surface being substantially co-planar and flat where the peripheral edge is joined to the inner edge. |
| US08946861B2 |
Bipolar device having a monocrystalline semiconductor intrinsic base to extrinsic base link-up region
Disclosed are bipolar devices, which incorporate an entirely monocrystalline link-up region between the intrinsic and extrinsic base layers, and methods of forming the devices. In the methods, a selective epitaxial deposition process grows monocrystalline semiconductor material for the extrinsic base layer on an exposed edge portion of a monocrystalline section of an intrinsic base layer. This deposition process is continued to intentionally overgrow the monocrystalline semiconductor material until it grows laterally and essentially covers a dielectric landing pad on a center portion of that same monocrystalline section of the intrinsic base layer. Subsequently, an opening is formed through the extrinsic base layer to the dielectric landing pad and the dielectric landing pad is selectively removed, thereby exposing monocrystalline surfaces only of the intrinsic and extrinsic base layers. A semiconductor layer is then formed by epitaxial deposition on the exposed monocrystalline surfaces, thereby forming the entirely monocrystalline link-up region. |
| US08946852B2 |
Photosensitive resin composition, photosensitive resin composition film, and semiconductor device using the photosensitive resin composition or photosensitive resin composition film
A photosensitive resin composition contains: (a) an alkali-soluble polyimide; (b) a compound which has two or more epoxy groups and/or oxetanyl groups in each molecule; and (c) a quinonediazide compound. Less than 10 parts by weight of an acrylic resin is contained per 100 parts by weight of the polyimide (a); and the content of the compound (b) is not less than 20 parts by weight per 100 parts by weight of the polyimide (a). |
| US08946849B2 |
BSI image sensor chips with separated color filters and methods for forming the same
A device includes a semiconductor substrate having a front side and a backside. A plurality of image sensors is disposed at the front side of the semiconductor substrate. A plurality of clear color-filters is disposed on the backside of the semiconductor substrate. A plurality of metal rings encircles the plurality of clear color-filters. |
| US08946845B1 |
Stacked pixels for high resolution CMOS image sensors with BCMD charge detectors
The invention describes in detail a solid-state CMOS image sensor, specifically a CMOS image sensor pixel that has stacked photo-sites, high sensitivity, and low dark current. The pixels have incorporated therein special potential barriers under the standard pinned photodiode region that diverts the photo-generated electrons from a deep region within the silicon bulk to separate storage structures located at the surface of the silicon substrate next to the pinned photodiode. The storage structures are p channel BCMD transistors that are biased to a low dark current generation mode during a charge integration period. The signal readout from the BCMD is nondestructive, therefore, without kTC noise generation. Thus a single pixel is capable of detecting several color-coded signals while using fewer or without using any light absorbing color filters on top of the pixel. The image sensors constructed with the stacked photo-sites with BCMD readout have higher pixel densities, higher resolution, higher sensitivity, very low dark current, and no color aliasing if at least three depth encoded signals are read from a single photodiode. The pixels having stacked photo-sites with BCMD readout are particularly suitable for a CMOS image sensor that is illuminated from the back side. |
| US08946840B2 |
Solid state imaging device, with suppressed dark current, method of manufacturing, and imaging apparatus
A solid state imaging device having a light sensing section that performs photoelectric conversion of incident light includes: an insulating layer formed on a light receiving surface of the light sensing section; a layer having negative electric charges formed on the insulating layer; and a hole accumulation layer formed on the light receiving surface of the light sensing section. |
| US08946834B2 |
High thermal stability free layer with high out-of-plane anisotropy for magnetic device applications
A CoFeB or CoFeNiB magnetic layer wherein the boron content is 25 to 40 atomic % and with a thickness <20 Angstroms is used to achieve high perpendicular magnetic anisotropy and enhanced thermal stability in magnetic devices. A dusting layer made of Co, Ni, Fe or alloy thereof is added to top and bottom surfaces of the CoFeB layer to increase magnetoresistance as well as improve Hc and Hk. Another embodiment includes a non-magnetic metal insertion in the CoFeB free layer. The CoFeB layer with elevated B content may be incorporated as a free layer, dipole layer, or reference layer in STT-MRAM memory elements or in spintronic devices including a spin transfer oscillator. Thermal stability is increased such that substantial Hk is retained after annealing to at least 400° C. for 1 hour. Ku enhancement is achieved and the retention time of a memory cell for STT-MRAM designs is increased. |
| US08946833B2 |
Packaging for semiconductor sensor devices and methods
A pressure sensor includes a first housing having a cavity. The pressure sensor further includes a pressure sensing device attached to a bottom of the cavity. The pressure sensor further includes a layer of gel over the pressure sensing device. The pressure sensor further includes a baffle in contact with the gel to reduce movement of the gel. |
| US08946832B2 |
Filter using a waveguide structure
A representative filter comprises a silicon-on-insulator substrate having a top surface, a metal shielding positioned above the top surface of the silicon-on-insulator substrate, and a band-pass filter device positioned above the metal shielding. The band-pass filter device includes a first port, a second port, and a coupling metal positioned between the first and second ports. |
| US08946821B2 |
SRAM integrated circuits and methods for their fabrication
SRAM integrated circuits are provided having pull up and pull down transistors of an SRAM cell fabricated in and on a silicon substrate. A layer of insulating material overlies the pull up and pull down transistors. Pass gate transistors of the SRAM cell are fabricated in a semiconducting layer overlying the layer of insulating material. |
| US08946819B2 |
Silicon-on-insulator integrated circuits with local oxidation of silicon and methods for fabricating the same
Silicon-on-insulator integrated circuits with local oxidation of silicon and methods for fabricating the same are provided. An integrated circuit includes a semiconductor substrate and a plurality of shallow trench isolation (STI) regions, each extending at least a first depth below an upper surface of the semiconductor substrate. The STI regions electrically isolate devices fabricated in the semiconductor substrate. The integrated circuit further includes a transistor that includes source and drain regions located in the semiconductor substrate, a gate dielectric layer located between the source and drain regions, and a local oxide layer located in a second portion of the semiconductor substrate and extending a second depth below the upper surface of the semiconductor substrate. The first depth is greater than the second depth. Still further, the integrated circuit includes a first gate electrode that extends over the gate dielectric layer and the local oxide layer. |
| US08946815B2 |
Floating body transistor constructions, semiconductor constructions, and methods of forming semiconductor constructions
The invention includes floating body transistor constructions containing U-shaped semiconductor material slices. The U-shapes have a pair of prongs joined to a central portion. Each of the prongs contains a source/drain region of a pair of gatedly-coupled source/drain regions, and the floating bodies of the transistors are within the central portions. The semiconductor material slices can be between front gates and back gates. The floating body transistor constructions can be incorporated into memory arrays, which in turn can be incorporated into electronic systems. The invention also includes methods of forming floating body transistor constructions, and methods of incorporating floating body transistor constructions into memory arrays. |
| US08946807B2 |
3D memory
Three-dimensional memory cells and methods of making and using the memory cells are discussed generally herein. In one or more embodiments, a three-dimensional vertical memory can include a memory stack. Such a memory stack can include memory cells and a dielectric between adjacent memory cells, each memory cell including a control gate and a charge storage structure. The memory cell can further include a barrier material between the charge storage structure and the control gate, the charge storage structure and the barrier material having a substantially equal dimension. |
| US08946801B2 |
Field effect transistors (FETs) and methods of manufacture
An improved field effect transistors (FETs) and methods of manufacturing the field effect transistors (FETs) are provided. The method of manufacturing a zero capacitance random access memory cell (ZRAM) includes comprises forming a finFET on a substrate and enhancing a storage capacitance of the finFET. The enhancement can be by either adding a storage capacity to the finFET or altering a portion of the finFET after formation of a fin body of the finFET. |
| US08946791B2 |
Finfet with reduced parasitic capacitance
A gate dielectric and a gate electrode are formed over a plurality of semiconductor fins. An inner gate spacer is formed and source/drain extension regions are epitaxially formed on physically exposed surface of the semiconductor fins as discrete components that are not merged. An outer gate spacer is subsequently formed. A merged source region and a merged drain region are formed on the source extension regions and the drain extension regions, respectively. The increased lateral spacing between the merged source/drain regions and the gate electrode through the outer gate spacer reduces parasitic capacitance for the fin field effect transistor. |
| US08946787B2 |
Reduced charge transistor
Representative implementations of devices and techniques provide a reduced charge transistor arrangement. The capacitance and/or charge of a transistor structure may be reduced by minimizing an overlap of a top gate with respect to a drain of the transistor. |
| US08946770B2 |
Semiconductor device with output circuit and pad
The present invention has for its purpose to provide a technique capable of reducing planar dimension of the semiconductor device. An input/output circuit is formed over the semiconductor substrate, a grounding wiring and a power supply wiring pass over the input/output circuit, and a conductive layer for a bonding pad is formed thereover. The input/output circuit is formed of MISFET elements in the nMISFET forming region and the pMISFET forming region, resistance elements in the resistance element forming regions and diode elements in the diode element forming regions functioning as protective elements. A wiring connected to the protective elements and positioned under the grounding wiring and the power supply wiring is pulled out in a pulling-out region between the nMISFET forming region and the pMISFET forming region and between the grounding wiring and the power supply wiring to be connected to the conductive layer. |
| US08946769B2 |
Lateral devices containing permanent charge
A lateral device includes a gate region connected to a drain region by a drift layer. An insulation region adjoins the drift layer between the gate region and the drain region. Permanent charges are embedded in the insulation region, sufficient to cause inversion in the insulation region. |
| US08946767B2 |
Monolithic semiconductor switches and method for manufacturing
A semiconductor device and method are disclosed. One embodiment provides a semiconductor die with a first n-type channel FET and a second n-type channel FET. A source of the first n-type channel FET and a drain of the second n-type channel FET are electrically coupled to at least one contact area at a first side. A drain of the first n-type channel FET, a gate of the first n-type channel FET, a source of the second n-type channel FET and the gate of the second n-type channel FET are electrically coupled to contact areas at a second side. Contact areas of the first n-type channel FET and the second n-type channel FET are electrically separated from each other. |
| US08946766B2 |
Bi-directional silicon controlled rectifier structure
Bi-directional silicon controlled rectifier device structures and design structures, as well as fabrication methods for bi-directional silicon controlled rectifier device structures. A well of a first conductivity type is formed in a device region, which may be defined from a device layer of a semiconductor-on-insulator substrate. An anode of a first silicon controlled rectifier is formed in the first well. A cathode of a second silicon controlled rectifier is formed in the first well. The anode of the first silicon controlled rectifier has the first conductivity type. The cathode of the second silicon controlled rectifier has a second conductivity type opposite to the first conductivity type. |
| US08946762B2 |
Light emitting diode and light emitting diode package
A light emitting diode includes a first semiconductor layer, an active layer, and a second semiconductor layer sequentially stacked on a substrate, and a first electrode connected to the first semiconductor layer. The first electrode includes an edge electrode including first and second edge portions opposite to each other, and a line electrode including first and second line portions respectively extending from the first and second edge portions. The edge electrode has a closed loop-shape. A distance between the first line portion and the second edge portion is equal to or less than a quarter of a length of the first line portion. A distance between the second line portion and the first edge portion is equal to or less than a quarter of a length of the second line portion. |
| US08946761B2 |
Radiation-emitting semiconductor chip and method for producing a radiation-emitting semiconductor chip
A radiation-emitting semi-conductor chip has a substrate and a semiconductor body arranged on the substrate and with a semiconductor layer sequence that includes an active region provided for producing radiation, an n-type region, and a covering layer arranged on a side of the n-type region that faces away from said active region. There is a contact structure arranged on the covering layer for the external electrical contacting of the n-type region. The covering layer has at least one recess through which the contact structure extends to the n-type region. |
| US08946760B2 |
Semiconductor light emitting device and fabrication method thereof
A semiconductor light emitting device includes a substrate having first and second electrode patterns on at least one surface thereof, a light emitting structure on a surface of the substrate, a first electrode structure, a second electrode structure, an insulating layer, a first connection portion connecting the first electrode structure and the first electrode pattern, and a second connection portion connecting the second electrode structure extending outwardly from the light emitting structure and the second electrode pattern. |
| US08946756B2 |
Optoelectronic semiconductor component
An optoelectronic semiconductor component (100) is specified, with a support (1) which has a mounting surface (11) and at least one penetration (3), where the penetration (3) extends from the mounting surface (11) to a bottom surface (12) of the support (1) that lies opposite the mounting surface (11); at least one optoelectronic semiconductor chip (2), which is mounted on the mounting surface (11); a radiation-transparent casting body (5), which surrounds the at least one optoelectronic semiconductor chip (2) at least in places, where the casting body (5) is arranged at least in places in the penetration (3) of the support (1). |
| US08946754B2 |
Flexible hermetic thin film with light extraction layer
A protected organic light emitting diode includes an organic light emitting diode structure formed on a substrate, a hermetic barrier layer formed over at least part of the organic light emitting diode structure, and a light extraction layer. The barrier layer may include a glass material such as a tin fluorophosphate glass, a tungsten-doped tin fluorophosphate glass, a chalcogenide glass, a tellurite glass, a borate glass or a phosphate glass. The light extraction layer, which may be formed over the barrier layer, includes a high refractive index matrix material and at least one of scattering particles dispersed throughout the matrix material and a roughened surface. |
| US08946751B2 |
Semiconductor light emitting device
A semiconductor light emitting device includes a first conductivity-type semiconductor layer, an active layer and a second conductivity-type semiconductor layer sequentially stacked on a substrate. A first electrode is disposed on a portion of the first conductivity-type semiconductor layer. A current diffusion layer is disposed on the second conductivity-type semiconductor layer and includes an opening exposing a portion of the second conductivity-type semiconductor layer. A second electrode covers a portion of the current diffusion layer and the exposed portion of the second conductivity-type semiconductor layer, wherein the portion of the current diffusion layer is near the opening. |
| US08946748B2 |
Semiconductor light emitting device including rear reflective part
There is provided a semiconductor light emitting device including: a light transmissive substrate; a light emitting part; first and second electrodes electrically connected to the first and second conductivity type semiconductor layers, respectively; and a rear reflective part including a reflective metallic layer, and a light transmissive dielectric layer interposed between the light transmissive substrate and the reflective metallic layer. |
| US08946746B2 |
Lead, wiring member, package part, metal part provided with resin and resin-sealed semiconductor device, and methods for producing same
A semiconductor device and manufacturing method therefor, provided with the aims of constraining resin burr formation while having good electric connectivity and joining strength, and LED device, provided with the aim of improving adhesion between silicon resin and leads while having good luminescent characteristics. |
| US08946742B2 |
Semiconductor package with through silicon vias
The substrate with through silicon plugs (or vias) described above removes the need for conductive bumps. The process flow is very simple and cost efficient. The structures described combines the separate TSV, redistribution layer, and conductive bump structures into a single structure. By combining the separate structures, a low resistance electrical connection with high heat dissipation capability is created. In addition, the substrate with through silicon plugs (or vias, or trenches) also allows multiple chips to be packaged together. A through silicon trench can surround the one or more chips to provide protection against copper diffusing to neighboring devices during manufacturing. In addition, multiple chips with similar or different functions can be integrated on the TSV substrate. Through silicon plugs with different patterns can be used under a semiconductor chip(s) to improve heat dissipation and to resolve manufacturing concerns. |
| US08946738B2 |
Light emitting device, light emitting module, and method for manufacturing light emitting device
According to one embodiment, a light emitting device includes a semiconductor layer, a p-side electrode, an n-side electrode, a first insulating layer, a p-side interconnect layer, an n-side interconnect layer, and a second insulating layer. The portion of the second p-side interconnect layer has the L-shaped cross section being configured to include a p-side external terminal exposed from the first insulating layer and the second insulating layer at a third surface having a plane orientation different from the first surface and the second surface. The portion of the second n-side interconnect layer has the L-shaped cross section being configured to include an n-side external terminal exposed from the first insulating layer and the second insulating layer at the third surface. |
| US08946735B2 |
Pixel structure of electroluminescent display panel
A pixel structure of electroluminescent display panel has a first sub-pixel region, a second sub-pixel region and a third sub-pixel region. The pixel structure of electroluminescent display panel includes a first organic light-emitting layer and a second organic light-emitting layer. The first organic light-emitting layer, which includes a first organic light-emitting material, is disposed at least in the first sub-pixel region and the second sub-pixel region. The second organic light-emitting layer, which includes a second organic light-emitting material and a third organic light-emitting material, is disposed at least in the second sub-pixel region and the third sub-pixel region. The first organic light-emitting layer and the second organic light-emitting layer overlap in the second sub-pixel region. The first sub-pixel region and the third sub-pixel region have different cavity lengths. |
| US08946730B2 |
Thin-film transistor device and method for manufacturing same, organic electroluminescent display element, and organic electroluminescent display device
In a thin film transistor device, partition walls define first, second, and third apertures. In plan view, at a bottom portion of the first aperture, a center of a total of areas of a source electrode portion and a drain electrode portion is offset from a center of area of the bottom portion in a direction differing from a direction of the third aperture, and at a bottom portion of one of the first and second apertures, a center a total of areas of a source electrode portion and a drain electrode portion is offset from a center of area of the bottom portion in a direction differing from a direction of the other one of the first and second apertures. |
| US08946726B2 |
Grid-UMOSFET with electric field shielding of gate oxide
A trench metal oxide semiconductor field effect transistor or UMOSFET, includes a buried region that extends beneath the trench and beyond a corner of the trench. The buried region is tied to a source potential of the UMOSFET, and splits the potential realized across the structure. This effectively shields the electric field from the corners of the trench to reduce gate oxide stress, and resultantly improves device performance and reliability. |
| US08946723B2 |
Epitaxial substrate and method for manufacturing epitaxial substrate
Provided is a crack-free epitaxial substrate having excellent breakdown voltage properties in which a silicon substrate is used as a base. The epitaxial substrate includes a (111) single crystal Si substrate and a buffer layer including a plurality of first lamination units. Each of those units includes a composition modulation layer formed of a first composition layer made of AlN and a second composition layer made of AlxGa1-xN being alternately laminated, and a first intermediate layer made of AlyGa1-yN (0≦y<1). The relationship of x(1)≧x(2)≧ . . . ≧x(n−1)≧x(n) and x(1)>x(n) is satisfied, where n represents the number of laminations of each of the first and second composition layers, and x(i) represents the value of x in i-th one of the second composition layers as counted from the base substrate side. The second composition layer is coherent to the first composition layer, and the first intermediate layer is coherent to the composition modulation layer. |
| US08946722B2 |
Organic light emitting display device and method of manufacturing the same
An organic light emitting display device with enhanced luminous efficiency and color viewing angle and a method of manufacturing the same are disclosed. The method includes forming a first electrode of each of red, green, blue and white sub-pixels on a substrate, forming a white organic common layer on the first electrodes, and forming a second electrode on the white organic common layer, wherein the first electrodes each includes multiple transparent conductive layers and is formed such that a thickness of the first electrode of each of two sub-pixels among the red, green, blue and white sub-pixels is greater than a thickness of the first electrode of each of the other two sub-pixels, and at least two layers excluding the lowermost layer among the multiple transparent conductive layers of each first electrode are formed to cover opposite sides of the lowermost layer. |
| US08946718B2 |
Semiconductor element and display device using the same
A semiconductor having an active layer; a gate insulating film in contact with the semiconductor; a gate electrode opposite to the active layer through the gate insulating film; a first nitride insulating film formed over the active layer; a photosensitive organic resin film formed on the first nitride insulating film; a second nitride insulating film formed on the photosensitive organic resin film; and a wiring provided on the second, nitride insulating film. A first opening portion is provided in the photosensitive organic resin film, an inner wall surface of the first opening portion is covered with the second nitride insulating film, a second opening portion is provided in a laminate including the gate insulating film, the first nitride insulating film, and the second nitride insulating film inside the first opening portion, and the semiconductor is connected with the wiring through the first opening portion and the second opening portion. |
| US08946712B2 |
Light blocking member having variable transmittance, display panel including the same, and manufacturing method thereof
A light blocking member having variable transmittance, a display panel including the same, and a manufacturing method thereof. A light blocking member having a variable transmittance according to one exemplary embodiment includes a polymerizable compound, a binder, and a thermochromic material that exhibits a black color at a temperature below a threshold temperature and becomes transparent at a temperature above the threshold temperature. |
| US08946710B2 |
Semiconductor device and electronic apparatus using the same
A semiconductor device with high function, multifunction and high added value. The semiconductor device includes a PLL circuit that is provided over a substrate and outputs a signal with a correct frequency. By providing such a PLL circuit over the substrate, a semiconductor device with high function, multifunction and high added value can be achieved. |
| US08946708B2 |
Transistor including an oxide semiconductor and display device using the same
The band tail state and defects in the band gap are reduced as much as possible, whereby optical absorption of energy which is in the vicinity of the band gap or less than or equal to the band gap is reduced. In that case, not by merely optimizing conditions of manufacturing an oxide semiconductor film, but by making an oxide semiconductor to be a substantially intrinsic semiconductor or extremely close to an intrinsic semiconductor, defects on which irradiation light acts are reduced and the effect of light irradiation is reduced essentially. That is, even in the case where light with a wavelength of 350 nm is delivered at 1×1013 photons/cm2·sec, a channel region of a transistor is formed using an oxide semiconductor, in which the absolute value of the amount of the variation in the threshold voltage is less than or equal to 0.65 V. |
| US08946701B2 |
Thin film transistor, array substrate and display device
Embodiments of the present invention provide a thin film transistor, an array substrate and a display device. The thin film transistor comprises a gate layer, a first insulating layer, an active layer, an etch stop layer and a source/drain electrode layer, wherein the active layer is made of a metal oxide material, the first insulating layer, the active layer, the etch stop layer and the source/drain electrode layer are sequentially stacked from bottom to top, the source/drain electrode layer contains an interval separating a source electrode and a drain electrode therein, the etch stop layer is located below the interval, and the etch stop layer has a width greater than that of the interval, and the first insulating layer comprises a laminate of a first sub-insulation layer and a second sub-insulation layer, the second sub-insulation layer is in contact with the active layer and made of an oxygen-rich insulating material. |
| US08946700B2 |
Semiconductor device and manufacturing method for the same
An object is to provide a method for manufacturing a highly reliable semiconductor device including thin film transistors which have stable electric characteristics and are formed using an oxide semiconductor. A method for manufacturing a semiconductor device includes the steps of: forming an oxide semiconductor film over a gate electrode with a gate insulating film interposed between the oxide semiconductor film and the gate electrode, over an insulating surface; forming a first conductive film including at least one of titanium, molybdenum, and tungsten, over the oxide semiconductor film; forming a second conductive film including a metal having lower electronegativity than hydrogen, over the first conductive film; forming a source electrode and a drain electrode by etching of the first conductive film and the second conductive film; and forming an insulating film in contact with the oxide semiconductor film, over the oxide semiconductor film, the source electrode, and the drain electrode. |
| US08946699B2 |
Display device, light-emitting device, lighting device, and electronic appliance
A light energy reuse type display device, light-emitting device, and lighting device with low power consumption, which efficiently convert light emitted from a light source (including light emission from a light-emitting element) into electric power, are provided. A photoelectric conversion element interposed between a pair of substrates functions as a color filter (a colored layer); thus, light emitted from a light source (including light emission from a light-emitting element) is efficiently converted into electric power, and a light energy reuse type display device, light-emitting device, and lighting device with low power consumption can be provided. |
| US08946696B2 |
Organic light emitting display
An organic light emitting display includes a thin film transistor substrate, and an organic light emitting device on the thin film transistor substrate, the organic light emitting device including a first electrode on the thin film transistor substrate, the first electrode being configured to reflect light, an organic layer on the first electrode and including at least an emitting layer, a transflective second electrode on the organic layer, and a color filter between the first electrode and the transflective second electrode. |
| US08946694B2 |
Organic light emitting display device with insulated balance electrode
An organic light emitting display device includes a substrate, a light emitting diode disposed on the substrate, and a balance electrode insulated from the light emitting diode and from each of the first and second electrodes. The light emitting diode includes a first electrode, a second electrode facing the first electrode, and an organic light emitting layer disposed between the first electrode and the second electrode. The balance electrode maintains a hole-electron charge balance within the organic light emitting layer by varying the amount of electrons and holes that are injected into the organic light emitting layer from the first and second electrodes by varying an electric potential applied to the balance electrode. |
| US08946691B2 |
Organic light-emitting display apparatus and method of manufacturing the same
An organic light-emitting display apparatus includes: a substrate; a pixel electrode disposed on the substrate; an intermediate layer that is disposed on the pixel electrode and includes an organic light-emitting layer; a facing electrode disposed on the intermediate layer; and a thin film encapsulating layer disposed on the facing electrode, wherein the thin film encapsulating layer includes: a first inorganic film and a second inorganic film, which are disposed on the facing electrode; a first organic film that is disposed between the first inorganic film and the second inorganic film and has a first thickness; and a second organic film that is disposed on the second inorganic film and has a second thickness greater than the first thickness. |
| US08946689B2 |
Microcavity OLEDs for lighting
Various methods and systems are provided for related to organic light emitting diodes (OLEDs) having a microcavity In one embodiment, a white-light source includes a first microcavity organic light emitting diode (OLED) configured to emit a narrow spectrum of blue light, a second microcavity OLED configured to emit a narrow spectrum of green light, and a third microcavity OLED configured to emit a narrow spectrum of red light In another embodiment, a light source includes a plurality of OLEDs disposed on a glass substrate Each of the OLEDs is configured to emit light in substantially orthogonal to the glass substrate in a predefined spectrum Each of the OLEDs includes a semi-reflecting mirror, and an emitting layer, where the emitting layer in each OLED corresponds to a respective color of light emitted by the OLED. |
| US08946687B2 |
Organic light emitting display devices and methods of manufacturing organic light emitting display devices
An organic light emitting display device is provided. Thin film transistors may be located on a substrate. An insulating interlayer having a first contact hole to a third contact hole may be disposed on the substrate. First electrodes electrically connecting the thin film transistors may be located on the insulating interlayer and sidewalls of the first to the third contact holes. A pixel defining layer may be disposed on the insulating interlayer, portions of the first electrodes and the sidewalls of the first to the third contact holes. Light emitting structures may be disposed on the first electrodes in pixel regions. A second electrode may be located on the light emitting structures. Planarization patterns may be disposed on the pixel defining layer to fill the first and the second contact holes. A spacer may be disposed on the pixel defining layer to fill the third contact hole. |
| US08946686B2 |
Organic EL display device with a multi-layered, resin-based planarization film
An organic EL display device (10) includes: an insulating substrate (20); a first planarizing film (21) formed on the insulating substrate (20) and made of a resin; a first electrode (13) formed on the first planarizing film (21); an organic EL layer (17) formed on the first electrode (13); a second electrode (14) formed on the organic EL layer (17); and a second planarizing film (22) formed between the first electrode (13) and the first planarizing film (21), and covering the first planarizing film (21). The second planarizing film (22) is made of a resin having a lower hygroscopic property than the resin forming the first planarizing film (21). |
| US08946682B2 |
Donor-acceptor fluorene scaffolds: a process and uses thereof
The present invention relates to novel donor-acceptor fluorene compounds, which can be used as for the fabrication of electroluminescent devices, and a process of preparing said novel compounds. More particularly, the present invention relates to amine donor and nitrile/ester acceptor fluorenes, fluorenones their π-conjugated systems and related compounds, processes for preparing the said compounds including oxidation of fluorenes to corresponding fluorenones and their use in preparing organic electronic devices such as organic light emitting diodes (OLEDs), photovoltaic/solar cell, Field effect transistors and other useful electroluminescent devices. The compounds are prepared by reacting 2H-pyran-2-ones in isolated or rigid conformations with cyclic ketones containing methylene carbonyl moiety in the presence of a base in an organic solvent. The present invention also relates to a new concept and approach to overcome the problem of ‘Green emission defect’ in 9-unsubstituted fluorene-based organic light emitting diodes which occurs due to the conversion of fluorenes to fluorenones that show emission mainly in green-yellow region. In the present invention we have placed donor-acceptor substituents in such a way that donor-acceptor fluorenones show emission in the blue region (instead of green-yellow region) thus improving the blue color purity and overcoming the problem of green emission defect. |
| US08946674B2 |
Group III-nitrides on Si substrates using a nanostructured interlayer
A layered group III-nitride article includes a single crystal silicon substrate, and a highly textured group III-nitride layer, such as GaN, disposed on the silicon substrate. The highly textured group III-nitride layer is crack free and has a thickness of at least 10 μm. A method for forming highly textured group III-nitride layers includes the steps of providing a single crystal silicon comprising substrate, depositing a nanostructured InxGa1-xN (1≧x≧0) interlayer on the silicon substrate, and depositing a highly textured group III-nitride layer on the interlayer. The interlayer has a nano indentation hardness that is less than both the silicon substrate and the highly textured group III-nitride layer. |
| US08946670B1 |
Three-dimensional semiconductor device, variable resistive memory device including the same, and method of manufacturing the same
A three-dimensional semiconductor device, a resistive variable memory device including the same, and a method of manufacturing the same are provided. The 3D semiconductor device includes a source formed of a first semiconductor material, a channel layer formed on the source and formed of the first semiconductor material, a lightly doped drain (LDD) region formed on the channel layer and formed of a second semiconductor material having a higher oxidation rate than that of the first semiconductor material, a drain formed on the LDD region and formed of the first semiconductor material, and a gate insulating layer formed on outer circumferences of the channel layer, the LDD region, and the drain. |
| US08946667B1 |
Barrier structure for a silver based RRAM and method
A method for forming a resistive switching device. The method includes providing a substrate having a surface region and forming a first dielectric material overlying the surface region of the substrate. A first wiring structure overlies the first dielectric material. The method forms a first electrode material overlying the first wiring structure and a resistive switching material comprising overlying the first electrode material. An active metal material is formed overlying the resistive switching material. The active metal material is configured to form an active metal region in the resistive switching material upon application of a thermal energy characterized by a temperature no less than about 100 Degree Celsius. In a specific embodiment, the method forms a blocking material interposing the active metal material and the resistive switching material to inhibit formation of the active metal region in the resistive switching material during the subsequent processing steps. |
| US08946659B2 |
Particle beam transport apparatus and method of transporting a particle beam with small beam spot size
An apparatus for transporting a charged particle beam is provided. The apparatus may include: means for scanning the charged particle beam on a target, a dipole magnet arranged upstream of the means for scanning, at least three quadrupole lenses arranged between the dipole magnet and the means for scanning, and means for adjusting the field strength of at least three quadrupole lenses in function of the scanning angle of the charged particle beam. The apparatus can be made at least single achromatic. |
| US08946657B2 |
Beam head
The present embodiments relate to a beam head including a vacuum housing, in which an electron source is arranged. The beam head also includes a beam finger that is connected to the vacuum housing and has an outlet window at a distal end. The beam head includes a transformer housing, in which a transformer connected to the electron source is arranged. The transformer housing is arranged directly on the vacuum housing. |
| US08946656B2 |
Methods and systems for radiation detection
An apparatus for detecting ionizing radiation from a source. A detector is disposed relative to the source to receive the ionizing radiation. The ionizing radiation causes ionization and/or excitation in the detector, wherein an optical property of the detector is altered in response to the ionization and/or excitation. A source of coherent probing light is disposed relative to the detector to probe the detector. The detector outputs the probing light, wherein the output light is modulated in response to the altered optical property. A receiver receives the output light and detects modulation in the output light. |
| US08946653B2 |
UV-C catheter hub sterilization and data acquisition system
A hand held hub sterilization and data acquisition device includes a housing having an opening for receiving a medical device, a sterilization chamber formed in the housing, a source of UV radiation disposed within the sterilization chamber for uniform emission of UV-C radiation into the sterilization chamber, and an RFID scanner configured into the housing. A patient care system includes a hand held hub sterilization and data acquisition device and an RFID enabled medical device. |
| US08946652B2 |
Sample positioning apparatus, sample stage, and charged particle beam apparatus
Provided is a sample positioning technology wherein micro-vibrations of a top table on which a sample is placed are suppressed such that the quality of an image to be observed or the precision of a measured dimension value can be improved. A sample positioning apparatus according to the present invention is provided with an active brake for stopping the top table, an inner frame which surrounds the active brake, an outer frame which surrounds the inner frame, and actuators for driving the active brake. The actuators, after driving the active brake to stop the top table with respect to a stage, press the outer frame to adjust the position of the top table. |
| US08946651B2 |
Multiple anode ion source
An ion source is provided. The ion source comprises a first cylindrical anode and a second cylindrical anode. The first cylindrical anode is concentric with the second cylindrical anode. The ion source further comprises an electron source positioned within the first cylindrical anode or the second cylindrical anode. |
| US08946648B2 |
Dual range digital nuclear spectrometer
A spectrometer (100) for detecting a source of radioactive emissions having a detector (120) that produces a detector signal (20), with an amplifier (30) followed by a single digitizer (40) followed by a digital signal processing unit (50), within which the signal processing implements two distinct pathways (51, 52), and associated firmware to utilize the two resulting sets of processed data in nuclear isotope identification. |
| US08946647B2 |
System and method for identifying non-cooperative pulsed radiation sources in a field-of-view of an imaging sensor
A system and method for identifying a pulsed radiation source may include an imaging sensor having a frame rate that is less than a pulse repetition frequency (PRF) of the pulsed radiation source. A processing unit may be in communication with the imaging sensor, and be configured to (i) process a sequence of image data of a scene captured by the imaging sensor to determine whether radiation of the pulsed radiation source is detected, (ii) determine a PRF code of the pulsed radiation source from possible multiple different PRF codes based on the processed sequence of image data, and (iii) notify a user of the PRF code or information associated with the PRF code. |
| US08946645B2 |
Radiation-monitoring diagnostic hodoscope system for nuclear-power reactors
A radiation-monitoring diagnostic hodoscope system for producing an approximate image of radiation-detecting components within or external to a pressure vessel of an operating, damaged, or shutdown nuclear-power plant. |
| US08946642B2 |
Versatile PET coincidence processor
A common or single type of positron emission tomography (PET) coincidence processor is useable with different PET systems. The ports are configurable to operate with different coincidence algorithms, allowing different numbers of ports to be used in different systems. The ports are configurable to provide different outputs and/or connect with different types of detectors. A programming port allows programming of an appropriate coincidence algorithm so that different such algorithms are usable by the controller. Any one or more of these accessible and/or versatile features are provided on a controller. |
| US08946631B2 |
Testing apparatus using charged particles and device manufacturing method using the testing apparatus
A substrate is irradiated by primary electrons and secondary electrons generated from the substrate are detected by a detector. A reference die is placed on the stage to obtain a pattern matching template image including feature coordinates of the reference die. A pattern matching is performed with an arbitrary die in a row or column including the reference die using the template image to obtain feature coordinates of the arbitrary die. An angle of misalignment is calculated between the direction of the row or column including the reference die and one of the directions of movement of the substrate on the basis of the feature coordinates of the arbitrary die and those of the reference die. The stage is rotated to correct the angle of misalignment to conform the direction of the row or column including the reference die with the one of the directions of movement of the substrate. |
| US08946629B2 |
Inspection apparatus
An inspection apparatus includes: beam generation means for generating any of charged particles and electromagnetic waves as a beam; a primary optical system that guides the beam into an inspection object held in a working chamber and irradiates the inspection object with the beam; a secondary optical system that detects secondary charged particles occurring from the inspection object; and an image processing system that forms an image on the basis of the detected secondary charged particles. The primary optical system includes a photoelectron generator having a photoelectronic surface. The base material of the photoelectronic surface is made of material having a higher thermal conductivity than the thermal conductivity of quartz. |
| US08946628B2 |
Electron beam interference device and electron beam interferometry
There is a limit in range and distance in which an electron beam can interfere and electron interference is implemented within a range of a coherence length. Therefore, interference images are consecutively recorded for each interference region width from an interference image of a reference wave and an observation region adjacent to the reference wave by considering that a phase distribution regenerated and observed by an interference microscopy is a differential between phase distributions of two waves used for interference and a differential image between phase distributions of a predetermined observation region and a predetermined reference wave is acquired by acquiring integrating phase distributions acquired by individually regenerating the interference images. This work enables a wide range of interference image which is more than a coherence length by arranging phase distribution images performed and acquired in the respective phase distributions in a predetermined order. |
| US08946626B2 |
Ion trap with spatially extended ion trapping region
A mass or mass to charge ratio selective ion trap is disclosed having an increased charge storage capacity. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC voltage and/or an RF voltage acts to confine ions in a second (x) direction within the ion trap. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. Ions are excited in the third (z) direction and are caused to be mass or mass to charge ratio selectively ejected in the third (z) direction. |
| US08946616B2 |
Analog-to-digital converter using variable counting interval and image sensor including same
An analog-to-digital converter (ADC) within an image sensor includes a comparator comparing a ramp signal with an image signal, and a counter generating a count result in response to the comparison by counting a clock during a counting interval. The ADC determines whether a first counting interval for the counter is less than a reference interval, and if the first counting interval is less than the reference interval the counting interval is a first counting interval, else the counting interval is a second counting interval. |
| US08946615B2 |
Image sensor circuit
The controlling circuit of the image censor circuit controls the row decoder to address the light receiving cell with the address signal to turn on the first MOS transistor and turns on the switch circuit with a switch controlling signal, and then controls the row decoder to turn off the first MOS transistor and then turns off the switch circuit with the switch controlling signal. |
| US08946613B2 |
Ultra low readout noise architecture having a pixel sensor with dual active pixel sensor pixel and dual ramp line
A method to read out pixels includes reading a first pixel by resetting a first photodetector, integrating the first photodetector after resetting the first photodetector, resetting a first floating diffusion node coupled to the first photodetector and a second floating diffusion node coupled to a second photodetector, transferring charge from the first photodetector to the first floating diffusion node, comparing a first signal at the first floating diffusion node and a second signal at the second floating diffusion node and generating a first signal to latch a first counter value when the first signal is less than the second signal, incrementing the first signal and decrementing the second signal, and comparing the first signal and the second signal and generating a second signal to latch a second counter value when the first signal is greater than the second signal, wherein the difference between the second counter value and the first counter value indicates a first pixel level. |
| US08946611B2 |
Solid-state imaging element and manufacturing method thereof, and electronic information device
A color filter is formed using a simple manufacturing method, and bias application to a pixel separating electrode allows sensitivity in low illumination intensity to be improved. In a solid-state imaging element, in which a plurality of unit pixel sections are disposed two dimensionally on a side closer to a front surface of a semiconductor substrate or a semiconductor layer, each unit pixel section having a light receiving section for generating a signal charge by light irradiation, an adjoining unit pixel section is formed in the same color to allow for lesser alignment accuracy of the color filter. A pixel separating electrode is formed in the adjoining unit pixel section, and a signal charge is shared by bias application during low illumination intensity, thereby improving an effective photodiode area. |
| US08946610B2 |
Semiconductor image sensor module and method of manufacturing the same
The present invention provides a CMOS type semiconductor image sensor module in which the aperture ratio of the pixel is improved and at the same time chip use efficiency is attempted to be improved and furthermore, simultaneous shuttering of all the pixels is made possible, and a method of manufacturing the same. The semiconductor image sensor module of the present invention is constituted by laminating a first semiconductor chip including an image sensor in which a plurality of pixels, each constituted by a photoelectric conversion element and transistors, are arranged, and a second semiconductor chip including an A/D converter array. Preferably, a third semiconductor chip including a memory element array is further laminated. Also, a semiconductor image sensor module of the present invention is constituted by laminating a first semiconductor chip provided with the aforesaid image sensor and a fourth semiconductor chip provided with an analog type nonvolatile memory array. |
| US08946606B1 |
Determining angular rate for line-of-sight to a moving object, with a body-fixed imaging sensor
Apparatus/method estimate LOS rotation, to track, approach, pursue, intercept or avoid objects. Vehicle-fixed imagers approach/recede-from objects, recording image series with background. Computations, from images exclusively, estimate rotation vs. the vehicle, applying the estimate. Preferably, recording/estimating provide proportional navigation; scan mirrors extend strapdown-sensor FOR; applying includes measuring “range rate over range”, exclusively from interimage optical flow, using results to optimize proportional-navigation loop gain; estimating includes evaluating interframe optical flow, preregistering roughly as first approximation, selecting sequence anchor points, and applying a second, finer technique developing output registration that's a coordinate translation, aligning inertial surroundings. The approximation operates optical flow with efficient embedded registration/mapping, applying a homography matrix to nearby imagery. Alternatively, inexpensive low-quality inertial sensors establish preregistration, deriving a homography matrix. When contrast in the object direction is inadequate, dual sensors yield accurate virtual imaging with an object centroid superposed into background. |
| US08946605B2 |
Microwave heating device and its application in chemical reactions
Disclosed herein is a microwave heating device. A material conduit runs into and out of a microwave irradiation cavity through a cavity wall of the microwave irradiation cavity. A waveguide tube for guiding microwave is installed on the cavity wall. A heat exchange tube is disposed inside the material conduit and enters and leaves the material conduit from the nozzle or wall of the material conduit. The microwave heating device is used in chemical reactions. The microwave heating device may control the temperature of the material inside the material conduit under continuous irradiation of microwave. |
| US08946604B2 |
Cooking oven with at least one convection heating device
The present invention relates to a cooking oven with at least one convection heating device (20). The convection heating device (20) is arranged in a rear wall (16) of the oven cavity (10). The convection heating device (20) includes at least two fans (26) and at least one ring element (28). The fans (22) are arranged side-by-side at the rear wall (16). A steam generator is provided for generating steam. At least two steam injectors (30) are provided, wherein each steam injector (30) corresponds with at least one fan (26). The steam injector (30) is directed along the radial axis of the corresponding fan (26), so that the steam is injected along the radial axis of said fan (26). |
| US08946602B2 |
Convection system and baffle for oven
An oven includes an oven chamber having a cavity at least partially defined by a door, a pair of side walls, and a rear wall; a baffle extending lengthwise between the pair of side walls, the baffle having an arcuate shape along at least a portion of its length; a heating element located between the baffle and the rear wall; and a first tangential fan configured to direct air over the heating element and through the baffle. The distance between the baffle and the rear wall is greater near the sidewalls than at the midpoint between the side walls. |
| US08946596B2 |
Multiple welding using a single power source
Welding systems are presented, in which a single power source provides a first DC output to a plurality of digital waveform controlled chopper modules. Welding modules are also disclosed for converting an input DC signal to a welding signal, which are comprised of a down-chopper for providing a welding signal waveform according to a pulse width modulated switching signal, along with a digital waveform controller providing the switching signal according to a desired waveform. |
| US08946590B2 |
Methods for laser scribing and separating glass substrates
Methods of forming scribe vents in a strengthened glass substrate having a compressive surface layer and an inner tension layer are provided. In one embodiment, a first and second defect is formed to partially expose the inner tension layer. A first scribe vent may be generated in a first scribing direction by translating a laser beam and a cooling jet on a surface of the strengthened glass substrate at a first scribing speed. A second scribe vent intersecting the first scribe vent may be generated in a second scribing direction by translating the laser beam and the cooling jet on the surface of the strengthened glass substrate at a second scribing speed that is greater than the first scribing speed. The defects may be perpendicular to the scribing directions. In another embodiment, the first scribe vent may be fused at an intersection location prior to generating the second scribe vent. |
| US08946588B2 |
Method and apparatus for improving reliability of a machining process
A process for providing a protection against damages in a machine head is claimed. The process comprises the following steps: First a blind steel plate (protection plate 20) is fixed to a protection chamber (10). Then the transparent liquid jet (WJ) guided laser beam (LB) is started, which drills a transit-hole into it. This protection plate (20) has the transit-hole (23) precisely arranged on the optical axis. Therefore no further alignment is required. Further an apparatus for treating a work piece by means of a laser beam (LB) which is guided in a transparent liquid jet (WJ) is claimed. The apparatus comprises a protection chamber (10) mounted on the output (5) of a coupling unit (CU) and a protection plate (20) replaceable fixed to the first chamber (10) protecting the outlet (15) of the first chamber (10) from sputtered debris. |
| US08946585B2 |
Method for the manufacture of a cutting tool
A method for the manufacture of a cutting tool provided with a tool holder (1) to which a cutter (2) is separably attached, includes applying a generative production process to a tool base body (3) to create the tool holder (1) with a desired finished shape. |
| US08946584B2 |
Angled cut height control system for a plasma arch torch
A method of controlling a position of a plasma arc torch relative to a workpiece for a bevel cutting operation is provided that includes: calculating a bevel pivot length, which is a function of a torch height; piercing the workpiece with the plasma arc torch; rotating the plasma arc torch about its center of rotation to a desired cutting angle; translating the plasma arc torch along at least one of X, Y, and Z axes to maintain a torch center point; and translating the plasma arc torch along at least one of the X, Y and Z axes to achieve a resultant displacement along a longitudinal axis of the plasma arc torch to maintain a desired torch height. |
| US08946583B2 |
Angled cut height control system for a plasma arch torch
A method of controlling the position of a tilt/tilt style plasma arc torch relative to a workpiece for a bevel cutting operation is provided that includes: calculating a bevel pivot length, wherein the bevel pivot length is a function of a torch height; piercing the workpiece with the plasma arc torch; adjusting a position of the plasma arc torch by at least one linear offset value based on the bevel pivot length; rotating the plasma arc torch about its center of rotation to the desired cutting angle and maintaining a torch center point; and translating the plasma arc along its longitudinal axis to maintain a desired arc voltage between the plasma arc torch and the workpiece. |
| US08946581B2 |
Switchgear
The switchgear includes a vacuum circuit breaker that is disposed in a circuit breaker chamber compartmented by a grounded metal plate, a busbar that is disposed in a busbar chamber and connected to the vacuum circuit breaker through a conductor, a cable that is disposed in a cable chamber and connected at one end to a load side, and a grounding device that is operated by a grounding device actuator disposed in a grounding device actuator chamber, connected to the vacuum circuit breaker through a conductor, and connected to the other end of the cable. The busbar is formed by a solid-insulated busbar. The conductor connecting the vacuum circuit breaker to the busbar and the conductor connecting the vacuum circuit breaker to the grounding device are both formed by a solid-insulated conductor. The circuit breaker chamber and the grounding device have a sealed structure. |
| US08946578B2 |
Touch panel and a manufacturing method thereof
The present disclosure relates to a touch technology, and more particularly, to a touch panel and a manufacturing method thereof. The present invention discloses a touch panel comprising a touch region, a first peripheral region at the first side of said touch region, a second peripheral region at the second side opposite to said first side, a plurality of first axial electrodes and second axial electrodes that intersect with each other diagonally to limit peripheral routing in the two peripheral regions, a plurality of peripheral first lead-wires disposed at the first peripheral region, and a plurality of second lead wares disposed at the second peripheral region. A manufacturing method of a touch panel is also provided. |
| US08946577B2 |
Auxiliary switch for an electrical switch
In at least one embodiment, an auxiliary switch includes a rotation part and a switching lever assigned to a configuration of the auxiliary switch, the switching lever being embodied to detect a switching state of the electrical switch and transmit it to the rotation part. Further, different switching states of the auxiliary switch are set by different rotary positions of the rotation part, with the rotation part having at least two engagement points and with the switching lever assigned to a configuration engaging in the engagement point assigned to this configuration. |
| US08946575B2 |
Push-button switch structure and electronic device having same
A switch through hole 22 is formed in a front cabinet 5a, and a press switch 21 is located in the front cabinet 5a to correspond to the switch through hole 22. With a pressing element 25 inserted in a plate through hole 28a of a reinforcing plate 28, an outer periphery of a middle portion of the pressing element 25 in an axial direction and the plate through hole 28a are connected by a silicone rubber 27. A key top 26 is coupled to one end of the pressing element 25 in the axial direction so as to be exposed from the switch through hole 22, and a switch assembly 24 is fitted in the switch through hole 22. This structure increases durability of a push-button switch, while increasing ease of assembly of a push-button switch structure. |
| US08946572B2 |
Rotary switch
A rotary switch includes a base forming a number of contacts, a support apparatus installed in the base, and a rotary apparatus rotatably installed in the support apparatus. The support apparatus forms zigzag first and second guiding portions. The rotary apparatus includes a rotary pole, a trigger mounted to the rotary pole, two abutting poles, and two resilient members respectively connected between two opposite ends of the rotary pole and the abutting poles. An end portion of each abutting pole slides along the first guiding portion, to allow the abutting poles to stretch and withdraw along a lengthwise direction of the rotary pole, and allow the abutting poles to undulate along the second guiding portion in a direction perpendicular to the lengthwise direction of the rotary pole, to allow the rotary pole to contact and trigger one of the contacts or pass over the contact. |
| US08946568B2 |
Electronic component enclosure and electronic apparatus
There is provided an electronic component enclosure. The electronic component enclosure includes: an upper enclosure and a lower enclosure. The upper enclosure includes: an upper plate portion; an upper sidewall portion extending from a periphery of the upper plate portion; and a hook member extending from the upper sidewall portion. The lower enclosure is engaged with the upper enclosure, and includes: a lower plate portion; a lower sidewall portion extending from a periphery of the lower plate portion; and a reception member extending from the lower sidewall portion and engaging with the hook member. |
| US08946565B2 |
Electrical junction box
An electrical junction box is provided which has a novel structure that enables connectors to be stably connected even when an L-shaped connecting terminal is used as a connecting terminal of a lateral connection type connector. An upward extending portion (92) extending upright from an internal circuit (87) of a connecting terminal (90) is sandwiched by a housing (114) of a lateral connection type connector (128) and a terminal support (42), a first lateral support rib (64a) is provided on the terminal support (42), a second lateral support rib (64b) is provided on the housing (114), and a connecting portion (93) of the connecting terminal (90) is sandwiched by the pair of lateral support ribs (64a) and (64b) from both sides in the width direction. |
| US08946558B2 |
Shielded electrical cable
A shielded electrical cable (2202) includes a conductor set (2204) and two generally parallel shielding films (2208) disposed around the conductor set (2204). The conductor set (2204) includes one or more substantially parallel longitudinal insulated conductors (2206). The shielding films (2208) include a parallel portion (2208) wherein the shielding films (2208) are substantially parallel. The parallel portion (2208) is configured to electrically isolate the conductor set (2204). |
| US08946557B2 |
Multilayer insulated electric wire and transformer using the same
A multilayer insulated electric wire having: a conductor; at least three extruded insulating layers covering the conductor; wherein an outermost layer (A) of the insulating layers is composed of an extruded coating layer containing a polyamide resin and the film thickness is 25 μm or less, wherein an inner layer (B) of the extruded insulating layers is composed of an extruded coating layer containing a crystalline resin having a melting point of 225° C. or more or an amorphous resin having a glass transition temperature of 200° C. or more. |
| US08946556B2 |
Shielded flat ribbon cable and method for fabricating a shielded flat ribbon cable
A shielded flat ribbon cable includes a plurality of insulated conductors being spaced parallel to each other, the insulated conductors each including an inner conductor and an insulation coating the inner conductor; an outer conductor bundling the insulated conductors together, the outer conductor including a first shell and a second shell in association with each other to sandwich the insulated conductors therebetween, each of the first shell and the second shell including a plurality of grooves covering outer surfaces of the insulated conductors, and a plurality of edge portions integral with both sides of the grooves, and gap formation-suppressing means for suppressing formation of gaps between the edge portions of the first shell and the edge portions of the second shell, respectively. |
| US08946555B2 |
Communication cable with improved crosstalk attenuation
Methods and apparatus directed towards communication cables and barrier tapes for use in communication cables are disclosed herein. In an embodiment, the present invention employs conductive segments within the communication cables and/or on the barrier tape. |
| US08946543B2 |
Propylene based resin composition and use thereof
Means for Solving the ProblemsThe thermoplastic resin composition (X1) of the present invention comprises (A1), (B1), (C1), and optionally (D1) below: 1 to 90 wt % of an isotactic polypropylene (A1); 9 to 98 wt % of a propylene/ethylene/α-olefin copolymer (B1) containing 45 to 89 mol % of propylene-derived structural units, 10 to 25 mol % of ethylene-derived structural units, and optionally, 0 to 30 mol % of C4-C20 α-olefin-derived structural units (a1); 1 to 80 wt % of a styrene-based elastomer (C1); and 0 to 70 wt % of an ethylene/α-olefin copolymer (D1) whose density is in the range of 0.850 to 0.910 g/cm3, wherein (A1)+(B1)+(C1)+(D1)=100 wt %. |
| US08946542B1 |
Solar module bonding method integrated into a pan structure
A pan structure for bonding solar modules installed on a target position is provided. The pan structure includes a plate member configured to be disposed across a spacing between two rail structures for mounting one or more solar modules. Additionally, the pan structure includes a pair of edge members configured to couple the plate member respectively with the two rail structures. Each of the pair of edge members has a first ledge characterized to be electrically conductive and configured to be supported by one of the two rail structures and a second ledge connected the first ledge to the plate member to keep the plate member a distance below the first ledge. Moreover, the pan structure includes a plurality of contact elements spatially distributed along the first ledge for bonding both the one or more solar modules and the rail structures for electric grounding. |
| US08946540B1 |
Imitation solar module for use in a staggered or irregularly shaped solar array
An imitation solar module for structural and aesthetic use in an array of electricity generating solar modules. The imitation solar module having a non-standard shape and a visual representation such as a decal of an actual solar module surface thereon. The imitation solar module includes triangular shapes for use in staggered module arrays. |
| US08946539B2 |
Junction cover for photovoltaic panel modules
A junction cover for a photovoltaic (PV) panel module system that includes a PV panel mounting structure, a rail, a PV module with a junction box and wiring extending between the rail and the junction box. The junction cover encloses the wiring and includes a base section, a nose section and a pair of feet. The base section includes a plate with first and second side walls extending downwardly therefrom to first and second edges to define an interior with an interior surface. The nose section extends from the base section to an open end and has a top wall, two sides formed by the side walls of the base section and an open side. The feet are located on either side of the open end of the nose section and extend therefrom. The feet engage the rail to secure the junction cover in place to enclose the junction box and wiring. |
| US08946538B2 |
Method and apparatus for generating electricity by thermally cycling an electrically polarizable material using heat from condensers
A method for converting heat to electric energy is described which involves thermally cycling an electrically polarizable material sandwiched between electrodes. The material is heated by extracting thermal energy from a gas to condense the gas into a liquid and transferring the thermal energy to the electrically polarizable material. An apparatus is also described which includes an electrically polarizable material sandwiched between electrodes and a heat exchanger for heating the material in thermal communication with a heat source, wherein the heat source is a condenser. An apparatus is also described which comprises a chamber, one or more conduits inside the chamber for conveying a cooling fluid and an electrically polarizable material sandwiched between electrodes on an outer surface of the conduit. A gas introduced into the chamber condenses on the conduits and thermal energy is thereby transferred from the gas to the electrically polarizable material. |
| US08946536B2 |
Electronic cymbal assembly with modular self-dampening triggering system
The present invention includes a method and apparatus for temporary dampening and temporary conversion of a wide range of an analog percussion surfaces into electronic percussive surfaces by means of a modular self-dampening trigger system attachable in an openly modular configuration to the underside of said analog percussive surfaces in a manner that allows physical variations to traverse different media and span distance and time and allowing for discrete detection and manipulation of said variations. A trigger system that is releasably attachable to an acoustic percussion element has a metal cover plate releasably affixable to an undersurface of the acoustic percussion element, the metal cover plate partially covering less than half of the undersurface. A plurality of piezo sensors are releasably affixable to the undersurface of the acoustic percussion element. A rubber dampening element with a footprint substantially similar to a footprint of the metal cover plate is formed from a flexible thin sheet of rubber with an opening corresponding to and aligned with each of the piezo sensors, the openings each sized slightly larger than the piezo sensor. The rubber dampening element is sandwiched between the undersurface of the cymbal and the metal cover plate. |
| US08946530B1 |
Hand-operated clapping percussion and rhythm device with controllable tone of sound
This invention, hand-operated clapping percussion and rhythm device with controllable tone of sound, provides the hand-operated percussion and rhythm device, producing the different tone of trembled sound. An improved hand-operated clapping percussion and rhythm device with controllable tone of sound comprises at least two of a plurality of blades rigidly tightened in the area of the handle portion by the tightening device and the tone of sound control device located in the lower portion of the blade portion, which includes the rest, nut, rigidly secured in the appropriate blade, and the regulator controlling the different gaps' size between the appropriate blades. |
| US08946528B2 |
Hybrids of, and cultivars derived from the rice cultivar designated ‘CL151’
Hybrids and derived cultivars of the rice cultivar designated ‘CL151’ are disclosed. The invention relates to hybrid rice seeds and plants produced by crossing the cultivar ‘CL151’ with another rice cultivar. The invention further relates to other derivatives of the rice cultivar ‘CL151.’ |
| US08946519B2 |
Soybean variety XB24N13
A novel soybean variety, designated XB24N13 is provided. Also provided are the seeds of soybean variety XB24N13, cells from soybean variety XB24N13, plants of soybean XB24N13, and plant parts of soybean variety XB24N13. Methods provided include producing a soybean plant by crossing soybean variety XB24N13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB24N13, methods for producing other soybean varieties or plant parts derived from soybean variety XB24N13, and methods of characterizing soybean variety XB24N13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB24N13 are further provided. |
| US08946513B2 |
Polyploid castor plants, compositions derived therefrom and uses of same
A polyploid castor plant being at least as fertile as a diploid castor plant isogenic to the polyploid castor plant when grown under similar conditions. |
| US08946512B2 |
Plants having enhanced yield-related traits and a method for making the same
The present invention relates generally to the field of molecular biology and concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of one or more nucleic acid(s) encoding at least two iSYT (interactor of SYT-synovial sarcoma translocation-) polypeptides. The present invention also concerns plants having modulated expression of a nucleic acid encoding at least two iSYT polypeptides, which plants have enhanced yield-related traits relative to corresponding wild type plants or other control plants. The invention also provides hitherto unknown nucleic acids encoding at least two iSYT polypeptides, and constructs comprising the same, useful in performing the methods of the invention. The invention also provides constructs useful in the methods of the invention. Furthermore the present invention also relates to an iSYT-based protein complex. It further relates to the use of the complex to promote plant growth, and to a method for stimulating the complex formation, by overexpressing at least two members of the complex. |
| US08946511B2 |
Plant microRNAs and methods of use thereof
This invention discloses novel microRNAs and their precursors, and recombinant DNA constructs including such novel miRNAs, miRNA precursors, miRNA promoters, and miRNA recognition sites corresponding to the miRNAs. Included are novel miRNA and miRNA precursors that exhibit nutrient-responsive expression. Also disclosed are miRNA decoy sequences. Further provided are non-natural transgenic plant cells, plants, and seeds containing in their genome a recombinant DNA construct of this invention and methods of controlling gene expression using recombinant DNA constructs of this invention. |
| US08946505B2 |
Promoter-regulated differentiation-dependent self-deleting cassette
Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. |
| US08946503B2 |
hnRNP A1 knockout animal model and use thereof
A nucleic acid construct comprising a genetic engineered heterogeneous nuclear ribonucleoprotein (hnRNP) A1 gene is provided. A transgenic mouse in which the expression of hnRNP A1 gene has been disrupted is also provided. The mouse is useful for studying the role of hnRNP A1 gene in normal and disease states of a developmental disorder and muscular diseases. Therefore, a method of screening a compound for potential use in prevention and/or treatment of developmental disorder and muscular diseases is further provided. |
| US08946501B2 |
Liquid leakage detection system
A liquid leakage detection system requiring no power supply from an outer source and configured to be relatively simple and moderate in price. A liquid leakage detection system (10) including an infusion tube (11), a syringe needle (12) coupled to the infusion tube (11), an absorbent element (16) adapted to be placed in the vicinity of a point (12a) of the syringe needle (12) to be pricked through a patient skin and a sensor unit (14) located on an upper side or within the absorbent element (16). |
| US08946500B2 |
Absorbent article with highlighted passive barrier
An absorbent article includes an absorbent core, a garment-facing surface, a body-facing surface, a first graphic visible at the body-facing surface, and a top component affixed to the article body and including an attached region and a cantilevered region, wherein the cantilevered region includes a translucent portion through which the first graphic is at least partially visible. The translucent portion can include a second graphic, wherein the first graphic and the second graphic combine to form the appearance of a third graphic. The article can also include a baffle forming at least part of the garment-facing surface, wherein the baffle includes a baffle graphic, and wherein at least a portion of the article body is translucent such that the baffle graphic is visible at the body-facing surface such that the first graphic and the baffle graphic combine to form the appearance of a fourth graphic. |
| US08946499B2 |
Systems, methods and materials for delivery and debonding on demand
Various systems, methods and materials are disclosed that enable efficient delivery of an agent into an adhesively adhered article, in which the agent elicits a desired outcome, on demand. This strategy, though general in scope, is also more specifically described with regard to enabling painless or atraumatic removal of products adhering to mammalian tissues such as skin and hair by suitably exploiting the ingress of an appropriate agent or like fluid. Other techniques and articles that aid in the handling or removal of such adhesive products are also disclosed. |
| US08946496B2 |
Process for preparing lower olefins from an oxygenate
The invention relates to a process for preparing lower olefins from an oxygenate, the process comprising: subjecting C4 hydrocarbons obtained in an oxygenate-to-olefins conversion step to extractive distillation to an etherification step to convert isobutene into an alkyl tertiary butyl ether to obtain an isobutene-depleted C4 hydrocarbon stream and alkyl tertiary-butyl ether; subjecting the isobutene-depleted C4 hydrocarbon stream to extractive distillation to obtain a stream enriched in unsaturated C4 hydrocarbons and a stream enriched in saturated C4 hydrocarbons; and recycling at least part of the stream enriched in unsaturated C4 hydrocarbons and/or at least part of the alkyl tertiary-butyl ether to the oxygenate-to-olefins conversion step. |
| US08946493B2 |
Method for producing pentafluoropropane
The present invention relates to a method for producing 1,2,3,3,3-pentafluoropropane, involving reacting gaseous phase 1,2,3,3,3-pentafluoropropene with hydrogen in a superstoichimetric amount in the presence of a hydrogenation catalyst in a reactor, and recirculating a part of the gaseous effluent from the reactor. |
| US08946491B2 |
Process for producing volatile organic compounds from biomass material
Embodiments of the present invention provide for production and recovery of ethanol or other volatile organic compounds, such as acetic acid, from solid biomass material. One embodiment comprises introducing a biomass material to a compartment of a solventless recovery system, wherein the biomass material contains one or more volatile organic compounds; contacting the biomass material with a superheated vapor stream in the compartment to vaporize at least a portion of an initial liquid content in the biomass material, said superheated vapor stream comprising at least one volatile organic compound; separating a vapor component and a solid component from the heated biomass material, said vapor component comprising at least one volatile organic compound; and retaining at least a portion of the gas component for use as part of the superheated vapor stream. |
| US08946490B2 |
Process for producing fatty alcohols by hydrogenation of fatty acid triglycerides on a copper-containing heterogeneous catalyst
The present invention relates to a process for preparing fatty alcohols, in which a stream comprising at least one fatty acid triglyceride is provided and this stream is subjected to a hydrogenation in the presence of a heterogeneous copper catalyst. |
| US08946488B2 |
Method for hydroxylating phenols and phenol ethers
A method for hydroxylating phenols and phenol ethers using hydrogen peroxide and specifically, a method for hydroxylating phenol using hydrogen peroxide. The method for hydroxylating a phenolic substrate selected from a phenol or a phenol ether by reacting such phenolic substrate with hydrogen peroxide in the presence of an acid catalyst comprises the following steps, implemented consecutively or simultaneously: a first step consisting of mixing a phenolic substrate with a hydrogen peroxide solution under conditions in which the temperature is sufficient for the initial phenolic substrate to remain liquid and for minimizing the conversion rate of the hydrogen peroxide; a second step consisting of carrying out the phenolic substrate hydroxylation reaction under adiabatic conditions, the acid catalyst being added at the mixing stage and/or at the beginning of the hydroxylation reaction; and a third step, if necessary, consisting of recovering the hydroxylated product. |
| US08946484B2 |
Method for producing phenol and/or cyclohexanone
In a process for producing phenol and cyclohexanone a feed comprising cyclohexylbenzene hydroperoxide and water in an amount from 1 to 15,000 ppm, based upon total weight of feed, is contacted with a cleavage catalyst comprising an aluminosilicate of the FAU type under cleavage conditions effective to convert at least a portion of the cyclohexylbenzene hydroperoxide into phenol and cyclohexanone. |
| US08946477B2 |
Solid forms of an N-(phenylmethyl) propanamide derivative and processes of preparation
The invention relates to solid forms of the anti-epileptic agent lacosamide (I). The invention also relates to mixtures of solid forms of lacosamide. The invention further relates to mixtures of lacosamide enantiomers crystallized in a conglomerate Form and the use thereof in providing enantiomerically enriched lacosamide, preferably lacosamide enriched with the (R)-enantiomer of lacosamide. |
| US08946476B2 |
Process for the preparation of amino acid derivatives
The present patent application relates to an alternative process for the preparation of amino derivatives. In particular, the present application relates to an improved process for the manufacture of Lacosamide (LCM), (R)-2-acetamido-N-benzyl-3-methoxypropion-amide, which is useful as an anticonvulsive drug. In a particular aspect, the present invention relates to a process of manufacture of optically enriched (R)-2-acetamido-N-benzyl-3-methoxypropion-amide (I) comprising resolution of 2-acetamido-N-benzyl-3-methoxypropion-amide (II). |
| US08946474B2 |
Polymorphic form of a calcimimetic compound
The present invention relates to the crystalline, polymorphic Form X of the calcimimetic compound {4-[(1R,3S)-3-((R)-1-Naphthalen-1-yl-ethylamino)-cyclopentyl]-phenoxy}-acetic acid, to methods of preparation thereof, to methods of characterization thereof by single crystal X-Ray crystallography (XRC), X-Ray Powder diffractometry, attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, Solid State NMR spectroscopy and Differential Scanning Calorimetry (DSC), and to its use. The invention also relates to the preparation of Form X by crystallization from a saturated solution of {4-[(1R,3S)-3-((R)-1-Naphthalen-1-yl-ethylamino)-cyclopentyl]-phenoxy}-acetic acid in a C1-C6 alkyl alcohol, or alternatively by precipitation from a neutralized saponification reaction mixture following the alkaline hydrolysis of a C1-C6 alkyl ester of {4-[(1R,3S)-3-((R)-1-Naphthalen-1-yl-ethylamino)-cyclopentyl]-phenoxy}-acetic acid. |
| US08946467B2 |
Process for liquid phase hydrogenation of phthalates
Disclosed is a process for the liquid phase hydrogenation of phthalates to cyclohexanoates. By using a reactor with a multiplicity of tubes, with a cooling fluid supplied to the outside of the tubes, shortcomings of traditional recycle mode fixed bed reactors can be overcome. Feed dilution can be avoided, resulting in much higher reaction rates. |
| US08946463B2 |
Process for the direct amination of alcohols using ammonia to form primary amines by means of a xantphos catalyst system
The present invention relates to a chemocatalytic liquid-phase process for the direct one-stage amination of alcohols to primary amines by means of ammonia in high yields using a catalyst system containing at least one transition metal compound and a xantphos ligand. |
| US08946462B2 |
Process for preparing formic acid by reaction of carbon dioxide with hydrogen
The invention relates to a process for preparing formic acid by reaction of carbon dioxide with hydrogen in a hydrogenation reactor in the presence of a transition metal complex as a catalyst comprising at least one element from group 8, 9 or 10 of the Periodic Table and at least one phosphine ligand with at least one organic radical having at least 13 carbon atoms, of a tertiary amine and of a polar solvent to form a formic acid-amine, adduct, which is subsequently dissociated thermally to formic acid and the corresponding tertiary amine. on unit. |
| US08946454B2 |
Chemical framework compositions and methods of use
The disclosure provides metal organic frameworks useful for sensing, gas sorption, microelectronics and switches. |
| US08946453B2 |
Chemical compounds
Disclosed are cyclic dione derivatives represented by formula (I), wherein the substituents are as defined in the description. The preparation method, intermediate and use thereof are also provided. |
| US08946449B2 |
Photoinitiators
Novel photoinitiators provide for polyurethane formation, in which a photoinitiator moiety and a tertiary amine are incorporated into the photoinitiator structure, and thus the polyurethane polymer. |
| US08946447B2 |
Insecticidal compounds
The invention relates to compounds of formula (I) where A1, A2, A3, A4, G, R1, R2, R3 and R4 are as defined in claim 1; or a salt or JV-oxide thereof. Furthermore, the present invention relates to processes and intermediates for preparing compounds of formula (I), to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising the compounds of formula (I) and to methods of using the compounds of formula (I) to control insect, acarine, nematode and mollusc pests. |
| US08946446B2 |
Pyrrolo sulfonamide compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-γ (ROR-γ, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases
The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administrating these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo sulfonamide compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof. |
| US08946445B2 |
Heterocyclic molecules as apoptosis inducers
The present document describes novel compounds which may inhibit the activity of anti-apoptotic proteins such as Bcl-2 family protein members, compositions containing the compounds and methods of treating diseases involving a defect in apoptosis, such as, for example, in the treatment of cancer. |
| US08946444B2 |
Tetrahydrocarbazoles as active agents for inhibiting VEGF production by translational control
The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for inhibiting VEGF production. |
| US08946443B2 |
Cyclopropanecarboxylic acid derivative
A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein R1 represents a C1 to C6 alkyl group which may be substituted by one to three groups selected from substituent group A, or the like (substituent group A: a hydroxy group, a halogeno group, a cyano group, a nitro group, an amino group, a carboxy group, a C1 to C3 alkyl group, etc.); R2, R3, and R8 each independently represent a hydrogen atom or a C1 to C3 alkyl group; R4, R5, R6, R7, R9, and R10 each independently represent a hydrogen atom or the like; and R11 represents a hydrogen atom or the like, has TAFIa enzyme inhibitory activity and is useful as a therapeutic drug for myocardial infarction, angina pectoris, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, or the like. |
| US08946442B2 |
Foamed ionic compounds
Foams of ionic compounds are described. Methods of making the foams are also provided. The foams are ionic and can be used for catalysis, separations, gas storage, biosensors, electronics, and electrochemical applications. |
| US08946438B2 |
Benzamides, production thereof, and use thereof as medicaments
Heteroaryloxy-substituted benzoic acid amides of general formula I wherein the groups R1 to R7 as well as X and Y are defined according to claim 1, including the tautomers, the stereoisomers, the mixtures and the salts thereof. The compounds according to the invention are suitable for the treatment of respiratory complaints, particularly COPD and asthma. |
| US08946435B2 |
Synthesis for thiazolidinedione compounds
The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases. |
| US08946430B2 |
Quinolinone carboxamide inhibitors of endothelial lipase
The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments. |
| US08946429B2 |
Kinetic resolution
While methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols (i.e., R—SH). The present invention relates to a method for resolving stereoisomeric mixtures of thiols. In particular, the present invention relates to purely organocatalytic mediated resolution of enantiomeric mixtures of thiols without the need for enzymes. Also disclosed are some novel catalysts. Such catalysts may comprise a cinchona alkaloid-derived moiety. |
| US08946425B2 |
Processes and intermediates for producing azaindoles
The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK). |
| US08946424B2 |
Deuterated amlexanox
Provided herein is technology relating to deuterated amlexanox and particularly, but not exclusively, to compositions comprising deuterated amlexanox, methods of producing deuterated amlexanox, and uses of deuterated amlexanox. |
| US08946423B2 |
Highly soluble salt of pyrroloquinoline quinone and method for producing the same
An object of the present invention is to provide a salt of pyrroloquinoline quinone having a high solubility in water and in an organic solvent and a method for producing the same. According to the present invention, there are provided an ammonium salt of pyrroloquinoline quinone having a high solubility in water and in an organic solvent, consisting of a pyrroloquinoline quinone ion and an ammonium salt having a hydroxyl group. |
| US08946422B2 |
8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents
The invention provides compound and salts of Formula I and II, disclosed herein, which includes compounds of Formula A and Formula B: Such compounds possess useful antimicrobial activity. The variables R2, R3, R5, R6, R7, and R9 shown in Formula A and B are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and/or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals. |
| US08946421B2 |
Lipidated imidazoquinoline derivatives
The compounds of the subject invention are adjuvant molecules that comprise an imidazoquinoline molecule covalently linked to a phospho- or phosphonolipid group. The compounds of the invention have been shown to be inducers of interferon-a, IL-12 and other immunostimulatory cytokines and possess an improved activity profile in comparison to known cytokine inducers when used as adjuvants for vaccine antigens. |
| US08946420B2 |
Neuromodulatory compounds
Provided herein are novel neuromodulatory compounds and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine and Parkinson's disease, using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein. In other embodiments, provided herein are methods of agonizing dopaminergic D2 receptors and/or antagonizing or inhibiting activity of receptors such as the 5-HT2 receptors using the compounds and compositions disclosed herein. |
| US08946419B2 |
(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
The present invention provides (+)-morphinanium compounds comprising substituted 6-hydroxy or 6-amine groups. The invention also provides methods for inhibiting microglial activation by administering the compounds of the invention. |
| US08946412B2 |
Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators
This invention relates to diazabicyclononyl oxadiazolyl derivatives, which are found to-be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances. Ar1 represents a pyrrolyl group, optionally substituted with alkyl or halo-alkyl. |
| US08946410B2 |
Automated radiosynthesis
The present invention provides a method to obtain radiofluorinated compounds useful for in vivo imaging GABAA receptors. The method of the invention is high-yielding and may conveniently be carried out on an automated synthesizer such as Fastlab™. A further aspect of the invention is a cassette suitable for carrying out the automated method of synthesis of the invention. Novel precursor compounds useful in the method of the invention are also provided, as are a number of novel compounds obtained by the method of the invention. |
| US08946409B2 |
Polycyclic β lactam derivatives for the treatment of cancer
Provided herein are polycyclic β-lactam compounds, compositions thereof and methods for the treatment and prevention of diseases such as cancer, including pancreatic cancer and pancreatic cancers resistant to mainline chemotherapeutic agents. |
| US08946408B2 |
Method for synthesizing beta lactam compounds by decomposition of an alpha-diazo-beta-ketoamide using a fluorescent light source
Novel methods for the production of enantiomerically pure (EP) β-lactams by decomposition of α-diazo-β-ketoamides using fluorescent light. |
| US08946403B2 |
Compositions and methods for siRNA inhibition of angiogenesis
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs. |
| US08946402B2 |
Inhibition of hairless protein mRNA
Methods for inhibition of hairless protein mRNA using RNA interference is described, in particular methods for hair removal. Also described are nucleic acid constructs for RNAi-mediated inhibition of hairless protein mRNA and compositions including such constructs. |
| US08946400B2 |
Sequence of dsRNA: ATN-RNA specific for tenascin-C
The subject matters of this invention are a sequence of double-stranded RNA: ATN-RNA, intervention using interference RNA (iRNAi), use of a sequence of double-stranded RNA: ATN-RNA, a method of treating a brain tumor and a method of inhibiting a brain tumor cells which express tenascin, a kit for inhibiting cancer cell which expresses tenascin and a method for a kit preparation in a brain tumor therapy. Malignant gliomas preferentially express a number of surface markers that may be exploited as therapeutic targets, including tenascin-C, an extracellular matrix glycoprotein that is ubiquitously expressed by malignant gliomas and probably contributes to tumor cell adhesion, invasion, migration and proliferation. For tenascin-C inhibition, RNA interference intervention (iRNAi) approach have been applied. |
| US08946399B2 |
Pathogen-inducible synthetic promoter
The invention relates to a pathogen-inducible synthetic promoter which is suitable for regulating the transcription of a nucleic acid, and includes a minimal promoter, characterized in that the minimal promoter includes a sequence motif a) dbrmwa or b) twcccmt which is disposed downstream from a TATA region and in front of a transcription starting point which is located on the minimal promoter and at which transcription of the nucleic acid to be regulated starts. |
| US08946395B1 |
Purification of proteins using hydrophobic interaction chromatography
The present invention is directed to methods for purifying a protein of interest, e.g., an antibody, from a sample comprising the protein of interest and at least one impurity, e.g., an aggregate, by employing a hydrophobic interaction chromatography (HIC) method that allows for binding of both the protein of interest and the at least one impurity under strong binding conditions. The present invention is based, at least in part, on the finding that both flow through and bind-elute techniques can be combined to achieve greater purification and recovery of a protein of interest, e.g., an antibody, under isocratic wash conditions and strong binding conditions. |
| US08946388B2 |
Monoclonal antibodies for treatment of cancer
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast Cancer, lung Cancer, gastric Cancer, ovarian Cancer, hepatocellular Cancer, colon Cancer, pancreatic Cancer, esophageal Cancer, head & neck Cancer, kidney Cancer, in particular renal cell Carcinoma, prostate Cancer, liver cancer, melanoma, sarcoma, myeloma, neuroblastoma, placental choriocarcinoma, cervical cancer, and thyroid Cancer, and the metastatic forms thereof. In one embodiment, the rumor disease is metastatic cancer in the lung. |
| US08946385B2 |
Chimeric Fcγ receptor and method for determination of ADCC activity by using the receptor
An objective of the present invention is to provide chimeric receptors containing a mouse Fcγ receptor extracellular domain and a human Fcγ receptor transmembrane domain, or chimeric receptors containing a mouse Fcγ receptor extracellular domain and a human γ chain transmembrane domain. Another objective of the present invention is to provide methods for measuring the ADCC activity of mouse antibodies and methods of screening for mouse antibodies having ADCC activity, using the chimeric receptors.To accomplish the above-mentioned objectives, the present inventors produced chimeric molecules by fusing the extracellular domain of mouse FcγR3 or mouse FcγR4 with the transmembrane domain/intracellular domain of human γ chain or human FcγR3, and expressed the chimeric molecules in human NK92 cells. It was revealed that the ADCC activity can be induced by the chimeric receptors produced by any combination of the domains, and that the ADCC activity of mouse antibodies can be measured using the chimeric receptors of the present invention. |
| US08946384B2 |
Polypeptide TF1 for inhibiting type 2 Shiga toxin activity, encoding gene for same and use thereof
The present invention provides a polypeptide TF1 for inhibiting type-2 Shiga-toxin activity, an encoding gene for the same and use thereof. The present polypeptide is named TF1 (also known as P1); its amino acid sequence is shown in SEQ ID NO: 1 in the sequence list. The polypeptide P1 can be prepared into medicine for preventing and/or treating diseases caused by type-2 Shiga toxin or the pathogens which produce type-2 Shiga toxin. |
| US08946383B2 |
Obtaining cocoa extracts rich in bioactive peptides with ACE and PEP enzyme inhibitory activity
The present invention relates to obtaining bioactive peptides from plant raw materials, specifically cocoa extracts, by means of enzyme treatment. Said biopeptides have angiotensin converting enzyme (ACE) and prolyl endopeptidase enzyme (PEP) inhibitory activity in vitro and/or antioxidant activity in vivo, being able to be used in the food, dietetic and pharmaceutical industry. |
| US08946379B2 |
Bladder cancer specific ligand peptides
The present invention is directed to bladder cancer specific ligand peptides, comprising the amino acid sequence X1DGRX5GF (SEQ ID NO:1), and methods of their use, e.g., for imaging detection for diagnosis of bladder, tumor localization to guide transurethral resection of bladder cancer, imaging detection of bladder cancer for follow-up after the initial treatment that can replace or complement costly cystoscopy, imaging detection of metastatic bladder cancer, and targeted therapy for superficial and metastatic bladder cancer. |
| US08946378B2 |
Sulfonation of conducting polymers and OLED, photovoltaic, and ESD devices
Conducting polymer systems for hole injection or transport layer applications including a composition comprising: a water soluble or water dispersible regioregular polythiophene comprising (i) at least one organic substituent, and (ii) at least one sulfonate substituent comprising sulfonate sulfur bonding directly to the polythiophene backbone. The polythiophene can be water soluble, water dispersible, or water swellable. They can be self-doped. The organic substituent can be an alkoxy substituent, or an alkyl substituent. OLED, PLED, SMOLED, PV, and ESD applications can be used. |
| US08946376B2 |
Semiconductors based on diketopyrrolopyrroles
The present invention relates to 1,4-diketopyrrolo[3,4-c]pyrrole (DPP) derivatives of the below formula to their manufacture; to their use as organic semiconductors, e.g. in semiconductor devices, especially a sensor, a diode, a photodiode, an organic field effect transistor, a transistor for flexible displays, and/or a solar cell (photovoltaic cell); to such semiconductor devices comprising diketopyrrolopyrrol derivatives of the formula I as a semiconducting effective means, and to devices containing said semiconductor devices. The compounds of the formula I have excellent solubility in organic solvents. High efficiency of energy conversion, excellent field-effect mobility, good on/off current ratios and/or excellent stability can be observed, when said compounds are used in semiconductor devices or organic photovoltaic (PV) devices. |
| US08946375B2 |
Method for making over-indexed thermoplastic polyurethane elastomer precursor and thermoplastic polyurethane elastomer made from the precursor
A method for making over-indexed thermoplastic polyurethane elastomer precursor. The precursor may be cross-linked. |
| US08946367B2 |
Polymerizable carbamate and thiocarbamate compounds, polymers derived from them, and compositions thereof
Carbamate and thiocarbamate compounds are described that comprise a polymerizable moiety and one or more free hydroxyl and/or thiol groups. Polymers may be obtained by polymerizing these carbamate and/or thiocarbamate compounds. The carbamate and thiocarbamate compounds, as well as the polymers they produce may be formulated into adhesive, agricultural, biocide, cleaning, coating, encapsulation, membrane, oilfield, performance chemical, and personal care compositions. |
| US08946365B2 |
Low molecular weight polystyrene resin and methods of making and using the same
A low z-average molecular weight, high softening point polystyrene resin having a narrow molecular weight distribution, as well as methods of making and using the same, are provided. The use of an inert solvent and/or the order of addition of reactants during polymerization may contribute to the unique properties of the final homopolymeric resin. The polystyrene resin can be partially or fully hydrogenated and may have particular use as a tackifying agent in a variety of hot melt adhesive and rubber compositions. |
| US08946364B2 |
Solution phase polydiacetylene synthesis by alkyne metathesis
The present disclosure provides compositions for alkyne metathesis catalysts and methods for preparing enediynes and alkyne metathesis catalysts. The disclosure also provides methods for catalyzing alkyne metathesis reactions and polymerization of enediyne substrates to polydiacetylenes in solution-phase. |
| US08946363B2 |
Solid particulate catalysts comprising bridged metallocenes
Solid, particulate catalysts comprising bridged bis indenyl π-ligands are disclosed, together with methods for the preparation and use thereof, for example, in olefin polymerization. |
| US08946360B2 |
Continuous flow polymerisation process
The present invention relates to a process for continuously preparing polymer by RAFT solution polymerization, the process comprising: introducing into a flow reactor a reaction solution comprising one or more ethylenically unsaturated monomers, RAFT agent, non-reactive solvent and free radical initiator; and promoting RAFT polymerization of the one or more ethylenically unsaturated monomers within the reactor so as to form a polymer solution that flows out of the reactor. |
| US08946357B2 |
Organosilicon compound, thermosetting resin composition containing the organosilicon compound, hardening resin and encapsulation material for optical semiconductor
A solution is a liquid organosilicon compound represented by general formula (1) as described below: wherein, X is each independently a group represented by formula (I), formula (II) or formula (III) as described below, and when the number of the group represented by formula (I) per one molecule of the liquid organosilicon compound represented by general formula (1) is defined as a, the number of the group represented by formula (II) per one molecule thereof is defined as b, and the number of the group represented by formula (III) per one molecule thereof is defined as c, 0≦a≦3.5, 0≦b≦3.5, and 0≦c≦1 are obtained, and also a+b+2c=4 is obtained: |
| US08946356B2 |
Resin composition and method of producing the same
A resin composition having a high thermal aging property and molding stability in mass production of molded articles while keeping molding fluidity and thermal creep resistance is provided. A resin composition, containing 100 parts by mass in total of a polypropylene resin (a) and a polyphenylene ether resin (b), and 1 to 20 parts by mass of a compatibilizer (c), wherein in the component (a), the proportion of the component having a molecular weight of 30,000 or less is from 3.0 to 5.1% of the entire component (a), and the proportion of the component having a molecular weight of 10,000,000 or more is from 1.0 to 1.6% of the entire component (a). |
| US08946354B2 |
Method for producing polymer particles
A method for producing polymer particles includes a preparation step for preparing a first oily liquid containing an oily olefin monomer, a radical polymerization initiator, and an iodine molecule, a synthesis step for obtaining a second oily liquid containing at least an iodine compound produced by a reaction between a radical generated by cleavage of the radical polymerization initiator and the iodine molecule in the first oily liquid, a suspension step for obtaining an oil droplet of the second oily liquid by suspending the second oily liquid in water, and a polymerization step for polymerizing the oily olefin monomer in the oil droplet. |
| US08946349B2 |
Rubber composition and process for production thereof, and tire
A rubber composition that can be used in applications such as automotive tires and can improve the fuel efficiency performance and driving stability of automobiles and the like, a method for producing a rubber composition, and a tire using the same are provided.A rubber composition comprising: (A) a conjugated diene rubber which is obtained by polymerizing a conjugated diene compound or polymerizing a conjugated diene compound and an aromatic vinyl compound and has a group having an active hydrogen and a group capable of chemically binding to a silica, (B) a silica, (C) a silane coupling agent (I) capable of reacting with a carbon-carbon double bond of the conjugated diene in the conjugated diene rubber, and (D) a silane coupling agent (II) capable of reacting with the group having an active hydrogen; a method for producing a rubber composition, which comprises mixing the above-mentioned composition; and a tire which is obtained by crosslinking and molding the rubber composition obtained by the method for production. |
| US08946348B2 |
Method for dissolving polyvinyl alcohol particles into aqueous media using high shear
Various processes and methods are disclosed for incorporating polyvinyl alcohol additives into products. In one embodiment, polyvinyl alcohol particles are dissolved in a solvent without the use of external heat to form a polyvinyl alcohol solution for incorporation into a product. In an alternative embodiment, polyvinyl alcohol particles are directly incorporated into a starch-based adhesive composition. Through the processes of the present disclosure, solid polyvinyl alcohol particles can be delivered directly to a manufacturing facility where the product that incorporates the polyvinyl alcohol additive is being made or formulated. In this manner, since the polyvinyl alcohol particles are not predissolved, the costs associated with shipping and transporting the polyvinyl alcohol product are greatly reduced. |
| US08946345B2 |
Method for the preparation of (polybutylene-co-adipate terephthalate) through the in situ phosphorus containing titanium based catalyst
Biodegradable compositions containing an aliphatic-aromatic copolyester derived from aromatic polyesters. Methods of making the compositions through an in situ phosphorus containing titanium based catalyst and articles made from the compositions. |
| US08946342B2 |
Random mat and fiber-reinforced composite material
There is provided a random mat of the present invention including: reinforcing fibers having an average fiber length of 5 to 100 mm; and a thermoplastic resin, wherein a fiber areal weight of the reinforcing fibers is from 25 to 3,000 g/m2, for a reinforcing fiber bundle (A) including the reinforcing fibers equivalent to or more than a critical single fiber number defined by formula (1), a ratio of the reinforcing fiber bundle (A) to a total amount of the reinforcing fibers in the mat is from 30 vol % to less than 90 vol %, and an average number (N) of the reinforcing fibers in the reinforcing fiber bundle (A) satisfies formula (2): Critical single fiber number=600/D (1) 0.7×104/D2 |
| US08946341B2 |
Polymer compositions comprising poly(arylether ketone)s and graphene materials
Polymer compositions comprising poly(aryl ether ketone)s and graphene materials. In particular, a polymer composition comprising: A) a poly(arylether ketone) and B) 0.1 to 70 wt. %, based on the combined weight of A) and B), of at least one non-tubular graphene material. Use of such polymer compositions for the manufacture of molded or extruded articles. Molded or extruded articles made from such polymer compositions. |
| US08946339B2 |
Modified conjugated diene-based polymer, method for producing the same, modified conjugated diene-based polymer composition, and tire
There is provided a modified conjugated diene-based polymer having a silyl group substituted with one or more alkoxy groups, and one or more nitrogen atoms on the chain ends of a conjugated diene-based polymer, the modified conjugated diene-based polymer being obtained by polymerizing a conjugated diene compound, or copolymerizing a conjugated diene compound with an aromatic vinyl compound, by using a polyfunctional anionic polymerization initiator prepared from a polyvinyl aromatic compound and an organolithium compound in a range of a molar ratio (the polyvinyl aromatic compound/the organolithium compound) of from 0.05 to 1.0, so as to obtain the conjugated diene-based polymer, and by reacting a living polymer end of the conjugated diene polymer with the compound having a silyl group substituted with two or more alkoxy groups, and one or more nitrogen atoms. |
| US08946335B2 |
Highly thermally conductive thermoplastic resin composition and thermoplastic resin
A thermoplastic resin composition according to the present invention contains an inorganic filler and a thermoplastic resin whose main chain contains a repeating unit represented by the general formula (1): -M-Sp- . . . (1) wherein M represents a mesogenic group; and Sp represents a spacer. |
| US08946331B2 |
Polypropylene resin composition and formed article
Disclosed is a polypropylene resin composition including: 100 parts by weight of (A) a propylene-based block copolymer including polymer components (I) and (II), wherein the polymer component (I) is a propylene polymer having an intrinsic viscosity [η]I of 0.1-5 dl/g, the polymer component (II) is a propylene polymer comprising propylene units and units of at least one comonomer selected from the group consisting of ethylene and α-olefins having 4-12 carbon atoms and having an intrinsic viscosity [η]II of from 1-20 dl/g and the content of the polymer component (II) is 1-70% by weight; and 0.001-5 parts by weight of (B) a nucleating agent composed of particles having an average particle diameter, as measured by the laser diffraction method, of 0.01-3 mm wherein particles having particle diameters of not less than 10 mm account for less than 5% by weight of all the particles of the nucleating agent. |
| US08946326B2 |
Bimodal polyethylene composition for injection moulded articles
Bimodal high density polyethylene composition for producing molded articles comprising—an ethylene homopolymer or an ethylene alpha-olefin copolymer which is a bimodal high density polymer (COMPONENT A) in combination with—an alphanucleating agent (COMPONENT B),—a slip agent being a primary fatty acid amide, (COMPONENT C) and—one or more additives selected from antioxidants, acid scavengers, pigments and UV-stabilizers (COMPONENT D), the composition showing an increased the crystallization temperature and a decreased coefficient of friction compared to a bimodal HDPE composition prepared with the sole use of nucleating agent and compared to the sole use of a slip agent; and its use for producing injection molded articles, especially caps and closures. |
| US08946324B2 |
Bulk material cover compositions and methods of applying
A cover material for a bulk material pile and method for applying the cover material are disclosed. The cover composition comprises liquid, cement and/or fly ash, fiber, water dispersible polymer and acid. |
| US08946323B2 |
Anionic wetting agents for stabilizing self-depositing compositions comprising oxidic pigments
The present invention relates to an acidic aqueous particulate composition containing, in addition to iron(III) ions, fluoride ions and at least one water-insoluble, dispersed organic binder, a water-insoluble, dispersed oxide pigment with elevated resistance to agglomeration for the autophoretic deposition of organic-inorganic hybrid layers onto metal surfaces, the composition additionally containing at least one anionic wetting agent which comprises functional groups selected from sulfonates, phosphonates and/or carboxylates. The invention furthermore comprises the use of such a composition for the autodeposition of a film-forming organic-inorganic hybrid coating onto metal surfaces which are at least in part selected from surfaces, the main constituents of which are iron, zinc and/or aluminum. |
| US08946320B2 |
Ink system containing polymer binders
An ink-jet ink composition includes a jettable vehicle, a plurality of pigment solids dispersed in the jettable vehicle, and a half-ester of styrene maleic anhydride (SMA) dispersed in the jettable vehicle. |
| US08946314B2 |
Expandable polyamide composition and polyamide foam obtained therefrom
The present invention relates to an expandable polyamide composition and to a polyamide foam obtained therefrom. This composition comprises a compound comprising at least one isocyanate function, a polyamide and a compound comprising at least one carboxylic acid function. The invention also relates to a process for preparing a polyamide foam from this composition. |
| US08946313B2 |
Hybrid PHD/PMPO polyols for polyurethane foam applications
This invention relates to hybrid polymer polyols. These hybrid polymer polyols comprise the free-radical polymerization product of (A) a base polyol comprising (1) a polymer modified polyol selected from (a) dispersions of polyureas and/or polyhydrazodicarbonamides in a hydroxyl group containing compound and (b) polyisocyanate polyaddition polyols, and (2) optionally, a polyol having a functionality of 2 to 6 and an OH number of from 20 to 500; (B) optionally, a preformed stabilizer; and (C) one or more ethylenically unsaturated monomers, in the presence of (D) a free-radical polymerization initiator, and (E) optionally, a polymer control agent. The present invention also relates to a process for the preparation of these hybrid polymer polyols, foams prepared from these hybrid polymer polyols and to a process for the preparation of these foams. |
| US08946311B2 |
Method for producing polyurethane insulating foams
The object of the invention is a method for producing polyurethane and/or polyisocyanurate insulating foam based on foaming reaction mixtures containing polyisocyanates, compounds having reactive hydrogen atoms, propellants, stabilizers, nucleation agents, and optionally further additives, which is characterized in that porous solids, in particular silicates having a zeolite structure, are used as the nucleation agents. |
| US08946303B2 |
Fatigue reducing agent
To maintain physical fitness and health of middle-aged and older persons living in the threshold of the aging society, the present invention provides a fatigue reducing agent which is highly effective for preventing and reducing fatigue, wherein the agent is made of a composition of substances that are very safe so that long-term administration is possible. A composition containing reduced coenzyme Q was found to be effective for preventing and reducing fatigue, including muscle fatigue. Since the fatigue reducing effect of the composition of the present invention is seen not only in young rats but also more pronounced in aged rats, the present invention can provide the fatigue reducing agent which is very useful, especially, for middle-aged and older persons as well as for young people. |
| US08946302B2 |
Selective sigma-1 receptor ligands
The invention provides compounds of the formulas described herein and compositions thereof. The invention further provides methods of using the compounds and compositions. The compounds of the invention can provide high affinity binding to sigma-1 receptors in a mammal. The compounds can exhibit selectivity for the sigma-1 receptor over the sigma-2 receptor. The compounds and compositions of the invention can also be used to treat conditions that involve the sigma-1 receptor, such as addiction, cardiovascular conditions, and cancer, for example, cancer of the breast, lung, prostate, ovarian, colorectal, or the CNS. |
| US08946294B2 |
Crystalline diacylhydrazine and the use thereof
The present disclosure provides crystalline polymorphic and amorphous forms of (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 1) or (S)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 2). The present disclosure further provides compositions comprising crystalline polymorphic and amorphous forms of Compound 1 or Compound 2 and an excipient, methods of making crystalline polymorphic or amorphous forms of Compound 1 or Compound 2, and methods of using crystalline polymorphic or amorphous forms of Compound 1 or Compound 2 to regulate gene expression in a cell or in a subject. |
| US08946291B2 |
Compositions and methods for treating pigmentary conditions and melanoma
A method of treating melanoma in a subject comprising administering an amount of SOX9 sufficient to treat melanoma is disclosed. A method of treating a hyperpigmentary condition in a subject comprising administering an amount of inhibitor of SOX9 activity sufficient to treat the condition is disclosed. A method of treating melanoma in a subject comprising administering an amount of SOX9 sufficient to treat melanoma is disclosed. A method of treating melanoma in a subject comprising increasing the amounts of retinoic acid and SOX9 in the subject by amounts sufficient to treat melanoma. A method of treating melanoma in a subject comprising administering an amount of prostaglandin D2 and retinoic acid sufficient to treat cancer is disclosed. A method of sensitizing a melanoma cell to RA comprising administering an amount of SOX9 sufficient to decrease PRAME expression is disclosed. |
| US08946285B2 |
Oligomer-opioid agonist conjugates
The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer. |
| US08946284B2 |
Methods and compositions involving (S)-bucindolol
Disclosed is bucindolol substantially free of its R-stereoisomer. Also disclosed are pharmaceutical compositions that include bucindolol substantially free of its R-stereoisomer or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. Also disclosed are methods of treating a patient that involve administering to the patient a therapeutically effective amount of a composition of the present invention. Formula (I). |
| US08946283B2 |
Composition for preventing or treating obesity, dyslipidemia, fatty liver or diabetes containing indole-3-carbinol derivative as active ingredient
Disclosed is a composition for preventing or treating obesity, dyslipidemia, fatty liver or diabetes, containing an indole-3-carbinol derivative as an active ingredient. The indole-3-carbinol derivative of the present disclosure can be usefully used as a pharmaceutical or functional food composition for preventing or treating obesity, dyslipidemia, fatty liver or diabetes by inhibiting differentiation of preadipocytes and reducing accumulation of triglyceride in cells. |
| US08946282B2 |
Indolin-2-one derivatives as protein kinase inhibitors
A novel class of indoline-2-one derivatives are disclosed. These compounds are protein kinase inhibitors which are useful for treating hyperproliferative diseases such as cancer. In one aspect, the invention relates to a compound a compound of Formula A: or a pharmaceutically acceptable salt thereof, wherein: Ra is hydrogen, (C6-C18)aryl, halo(C6-C18)aryl, or (C1-C6)alkoxy(C6-C18)aryl; Rb is hydrogen, (C3-C18)heteroaryl, (C1-C6)alkoxy(C3-C18)heteroaryl; (C1-C6)alkyl(C3-C18)heteroaryl, (C1-C6)alkyl(C1-C6)alkoxy(C3-C18)heteroaryl, (C1-C6)alkyl(C1-C6)carboxyalkyl(C3-C18)heteroaryl; (C1-C6)alkyl(C1-C6)alkylamino(C1-C6)alkylcarbamoyl)(C3-C18)heteroaryl, (C1-C6)alkyl(C1-C18)aryl(C3-C18)heteroaryl, (C1-C6)alkyl(C1-C6)alkoxycarbonyl)(C3-C18)heteroaryl, (C1-C6)alkyl(C1-C6)alkoxy(C1-C6)oxyalkyl(C3-C18)heteroaryl, (C1-C6)alkyl(C3-C6)heterocyclylcarbonyl(C3-C18)heteroaryl, (C1-C6)alkyl(C3-C6)heterocyclyl(C1-C6)oxyalkyl(C3-C18)heteroaryl, or (C1-C6)alkyl((C3-C6)heterocyclyl(C1-C6)alkylcarbamoyl)(C3-C18)heteroaryl; Rc is hydrogen, (C1-C6)alkoxybenzoylureido, or halo(C6-C18)aryl(C3-C18)heteroarylamido; Rd is hydrogen, halogen, (C1-C6)alkoxybenzoylureido, or halo(C6-C18)aryl(C3-C18)heteroarylamido; Re is-hydrogen, benzoylureido, halobenzoylureido, halo(C1-C6)alkoxybenzoylureido, (C1-C6)alkoxybenzoylureido, (C1-C6)alkylaminobenzoylureido, (C1-C6)alkylbenzoylureido, nitrobenzoylureido, (C1-C6)haloalkylbenzoylureido, (C1-C6)haloalkylhalobenzoylureido, halo(C6-C18)arylcarbomylacetamido, (C1-C6)alkoxy(C6-C18)arylcarbomylacetamido, (C1-C6)alkoxy(C6-C18)arylcarbamoyl(C3-C6)cycloalkylamido, halo(C6-C18)aryl(C3-C18)heteroarylcarbonylamino, (C3-C6)cycloalkyl(C3-C18)heteroarylcarbonylamino, (C1-C6)alkylamino(C6-C18)aryl(C3-C18)heteroarylcarbonylamino, halo(C1-C6)alkoxy(C6-C18)aryl(C3-C18) heteroarylcarbonylamino, (C1-C6)alkoxy(C6-C18)aryl(C3-C18)heteroarylcarbonylamino, (C1-C6)alkyl(C3-C18)heteroarylcarbonylamino, aryl(C3-C18)heteroarylcarbonylamino, (C1-C6)haloalkylhalo(C6-C18)aryl(C3-C6)heterocyclylcarbonylamino, (C1-C6)haloalkyl(C6-C18)aryl(C3-C18)heteroarylcarbonylamino, halo(C6-C18)aryl(C3-C18)heteroarylamido, (C1-C6)oxyalkyl(C3-C6)heterocyclylamido, (C1-C6)alkoxy(C1-C6)alkyl(C3-C18)heteroarylamido, (C6-C18)aryl(C3-C18)heteroarylamido, (C1-C6)alkyl(C1-C18)aryl(C3-C18)heteroarylamido, (C1-C6)haloalkyl(C6-C18)aryl(C3-C18)heteroarylamido, (C1-C6)alkyl(C3-C18)heteroarylamido, or (C1-C6)alkoxy(C6-C18)aryl(C3-C18)heteroarylamido; and Rf is hydrogen, (C1-C6)alkoxybenzoylureido, or halo(C6-C18)aryl(C3-C18)heteroarylamido. |
| US08946281B2 |
Ketorolac tromethamine compositions for treating or preventing ocular pain
Compositions comprising ketorolac tromethamine at a therapeutically effective concentration of less than 0.5% are disclosed herein. Methods of treating or preventing ocular pain using said compositions are also disclosed herein. |
| US08946279B2 |
Fused ring compound for use as mineralocorticoid receptor antagonist
The present invention belongs to the technical field of medicine, relating in particular to: a fused ring compound as represented by Formula (I) for use as a mineralocorticoid receptor antagonist, a pharmaceutically acceptable salt thereof, and an isomer thereof; a preparation method for these compounds; a pharmaceutical preparation containing these compounds; and an application of these compounds, the pharmaceutically acceptable salt thereof, or the isomers thereof in the preparation of medicants for the treatment and/or prevention of kidney injury, cardiovascular diseases such as hypertension, and/or endocrine disease. The definitions of X, Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4, Cy and n are as presented in the description. |
| US08946277B2 |
Clonidine formulations in a biodegradable polymer carrier
Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days. |
| US08946267B2 |
Therapeutic agent or prophylactic agent for neuropathic pain
A therapeutic agent or a prophylactic agent for neuropathic pain provides a synergistically-enhanced analgesic effect at a dose at which a calcium channel α2δ ligand does not produce any side effects as well as which agent does not produce any new side effects on the central nervous system. The therapeutic agent or a prophylactic agent for neuropathic pain includes as effective ingredients a cyclohexane derivative, represented by the following formula, or a pharmaceutically acceptable salt thereof or a prodrug thereof, and a calcium channel α2δ ligand. |
| US08946265B2 |
Process for the preparation of lenalidomide
The present invention relates to improved processes for preparing 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione (I) (lenalidomide) and its intermediate 3-(1-oxo-4-nitro-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione. The present invention further relates to improved processes for preparing lenalidomide crystalline form A, use of said crystalline form A as an active pharmaceutical ingredient or as an intermediate in the preparation of further crystalline or amorphous forms of lenalidomide, compositions comprising lenalidomide crystalline form A and their use in the treatment of disease. |
| US08946261B2 |
Substituted 1, 2, 3, 4-tetrahydroquinolin-7-yl carbamates as acetylcholinesterase inhibitors for treatment of Alzheimer's disease
The present invention relates to novel substituted 1,2,3,4-tetrahydroquinolin-7-yl carbamates, their preparation, and use as therapeutic agents, particularly in the prevention or treatment of neurodegenerative or Alzheimer's disease, or senile dementia, or memory disturbances, and more particularly to the prevention, treatment and amelioration of Alzheimer's disease with the novel substituted 1,2,3,4-tetrahydroquinolin-7-yl carbamates, which act as inhibitors of central cholinesterase enzymes, particularly acetylcholinesterase (AChE) following the indirect cholinomimetic pathway. The present invention particularly relates to compounds of formula A: Formula A wherein R1=alkyl, aryl, substituted aryl; R2=H, methyl; R3=H, alkyl, alkenyl, alkynyl, aralkyl, substituted aralkyl, aryl, heteroaryl. |
| US08946258B1 |
Methods of non-gastrointestinal endoscopic procedures using L-hyoscyamine oral formulations
Methods of performing non-gastrointestinal endoscopic procedures with concomitant dosing with rapidly disintegrating oral formulations of single active ingredient L-Hyoscyamine rapidly dissolving tablets. |
| US08946256B2 |
Compositions and methods for treatment of vitiligo
Compositions and methods are disclosed for treating vitiligo and promoting the formation of collagen. |
| US08946254B2 |
Bivalent ligands for the treatment of neurological disorders
Bivalent ligands that contain two pharmacophores linked through a spacer, one of which interacts with the μ-opioid receptor (MOR) and the other of which interacts with the co-receptor CC chemokine receptor 5 (CCR5), are used for the treatment of neurological disorders such as those associated with AIDS. |
| US08946249B2 |
Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use
Compound of Formula A and pharmaceutically acceptable salts thereof and crystalline Forms I and II of Compound of Formula A! Also, methods for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods for their uses. |
| US08946248B2 |
HIV inhibiting 5-substituted pyrimidines
HIV replication inhibitors of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein A is —CH2—CH2—, —CH═CH—, —C≡C—; R1 is hydrogen, aryl, formyl, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl, R2 hydroxy, halo, C1-6alkyl, carboxyl, cyano, —C(═O)R6, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl; X1 is —NR1—, —O—, —S—, —S(═O)p—; R3 is H, C1-6alkyl, halo; R4 is H, C1-6alkyl, halo; R5 is nitro, amino, mono- and diC1-4alkylamino, aryl, halo, —CHO, —CO—R6, —COOR7, —NH—C(═O)H, —NH—C(═O)R6, —CH═N—O—R8; R6 is C1-4alkyl, amino, mono- or di(C1-4alkyl)amino or polyhaloC1-4alkyl; R7 is hydrogen, C1-6alkyl, arylC1-6alkyl; R8 is hydrogen, C1-6alkyl, aryl; p is 1 or 2; aryl is optionally substituted phenyl; pharmaceutical compositions containing these compounds as active ingredient and processes for preparing said compounds and compositions. |
| US08946244B2 |
2′-fluoro-6′methylene carbocyclic nucleosides and methods of treating viral infections
The present invention relates to 2′-Fluoro-6′-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Hepatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses. |
| US08946243B2 |
Compounds and methods for the treatment of viral infection
The invention relates to compounds and methods for treating or preventing a viral infection, by administering a monophosphorylated prodrug of acyclovir or monophosphorylated derivative of an acyclovir prodrug to a subject suffering from or susceptible (to a viral infection, such as HIV infection. |
| US08946242B2 |
Spiro[2.4]heptanes for treatment of flaviviridae infections
Compounds, methods, and compositions for the treatment of infections in or exposure to humans and other host animals of Flaviviridae viruses, including HCV, that includes the administration of an effective amount of a spiro[2.4]heptane as described herein or a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable carrier, are provided. The spiro[2.4]heptane compounds either possess antiviral activity, or are metabolized to a compound that exhibits such activity. |
| US08946241B2 |
Tyrosine kinase inhibitors
The present disclosure provides compounds such as such as pyrazolpyrimidine compounds, and pharmaceutically acceptable salts thereof, that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and pharmaceutically acceptable salts thereof and processes for preparing such compounds and pharmaceutically acceptable salts thereof. |
| US08946240B2 |
4-amino-3-(imidazolyl)-pyrazolo[3,4-D]pyrimidines
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are 4-amino-3-imidazoyl-pyrazolo[3,4-d]pyrimidine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists. |
| US08946238B2 |
Pyrazolo[1,5-A]pyrimidines as antiviral agents
The invention provides compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections. The compounds and compositions are useful for treating Pneumovirinae virus infection including Human respiratory syncytial virus infections. |
| US08946237B2 |
Pyrazolo[1,5-A]pyrimidines as mark inhibitors
The invention encompasses pyrazolo[1,5-a]pyrimidine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included. |
| US08946235B2 |
2-(2,4,5-substituted-anilino) pyrimidine compounds
The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using such compounds and salts thereof. |
| US08946232B2 |
Human protein tyrosine phosphatase inhibitors and methods of use
The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to compositions comprising said human protein tyrosine phosphatase beta (HPTP-β) inhibitors, and to methods for regulating angiogenesis. |
| US08946229B2 |
Formulations
The present invention relates to pharmaceutical compositions for oral administration of active compounds. |
| US08946226B2 |
Use of CDK inhibitor for the treatment of glioma
The invention provides a low molecular weight ATP-competitive CDK inhibitor able to cross the blood brain barrier for use in the treatment of malignant glioma and, in particular, of glioblastoma. The compound can be administered together with one or more agents selected from the group consisting of cytotoxic or cytostatic agents and ionizing radiation. |
| US08946225B2 |
Derivatives of 2H pyridazin-3-ones, their preparation and their use as SCD-1 inhibitors
The present invention concerns compounds of general formula (I) characterized in that (formula 1) wherein, in particular: —R1 represents one or more groups such as: trifluoromethyl, halogen such as F, Cl, —when n=m=1, W represents CH then Y represents oxygen, —U represents: •either —(C═O)CH2NH— and is branched at position 4 of pyridazinone, then R2 represents H, •or —(C═O)NH— and U is branched at positions (4), (5) or (6) of pyridazinone, then R2 represents H, —R3 represents a hydrogen or methyl and the addition salts with pharmaceutically acceptable bases and acids and the different isomers, and their mixtures in any proportion for use as SCD-1 enzyme inhibitors for the treatment of obesity, type-2 diabetes and lipid disorders. |
| US08946224B2 |
Substituted [1,2,4]triazolo[4,3-A]pyrazines for medicaments and pharmaceutical compositions
The present invention relates to derivatives of known active pharmaceutical compounds. These derivatives are differentiated from the parent active compound by virtue of being redox derivatives of the active compound. This means that one or more of the functional groups in the active compound has been converted to another group in one or more reactions which may be considered to represent a change of oxidation state. We refer to these compounds generally as redox derivatives. The derivatives of the invention may be related to the original parent active pharmaceutical compound by only a single step transformation, or may be related via several synthetic steps including one or more changes of oxidation state. Exemplary derivatives have the formula |
| US08946209B2 |
Compositions and methods for treating and preventing urolithiasis and conditions associated therewith
Compositions and methods for the treatment of urinary calculi and fragments thereof are provided. Compositions and methods for the prevention and/or treatment of renal and urinary colic caused by urinary calculi or fragments are also provided. Such compositions and methods provide locally effective amounts of diazepam sufficient to prevent formation of and/or expel ureteral calculi and fragments thereof and thus prevent and/or treat pain associated with calculi and fragments thereof. |
| US08946208B2 |
Non-aqueous pharmaceutical composition
A composition for intranasal delivery of a drug comprising: includes: (i) the drug; and (ii) a non-aqueous vehicle containing (a) propylene glycol and at least one additional solvent selected from N-methylpyrrolidone, propylene carbonate, dimethyl sulfoxide and at least one propylene glycol fatty acid ester; (b) from about 40 to 100% by volume of N-methylpyrrolidone; or (c) from about 40 to 100% by volume of dimethyl sulfoxide (DMSO). |
| US08946206B2 |
Methods for improving cognitive function
Provided herein are methods, drug formulations, and dosing regimens for improving cognitive function in a normal or cognitively impaired subject. For instance, methods provided herein comprise administering a GABAA receptor antagonist so that peak concentration of the GABAA receptor antagonist occurs when the subject is asleep. |
| US08946204B2 |
Substituted phenylureas and phenylamides as vanilloid receptor ligands
Substituted phenylureas and phenylamides, processes for their preparation, pharmaceutical compositions containing these compounds, and the use of these compounds for preparing pharmaceutical compositions. |
| US08946203B2 |
Benzodioxane inhibitors of leukotriene production
The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds. |
| US08946202B2 |
Substituted porphyrins
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods. |
| US08946198B2 |
Estrogen replacement regimen
The present invention provides an improved method to deliver estrogen to menopausal women comprising administering ultra-low dose estradiol alternating with standard-dose estradiol. |
| US08946195B2 |
Bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators
The present invention relates to novel bicyclic methyl amine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors. |
| US08946194B2 |
One-step processing of hydrogels for mechanically robust and chemically desired features
The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials. |
| US08946193B2 |
Medical uses of glucans
The invention relates to a glucan having a beta-(1,3)-backbone with one or more beta-(1,3)-side chains linked thereto for use in the treatment of asthma and related diseases of abnormal pulmonary function in an animal. Also described is a method of treating asthma and related diseases of abnormal pulmonary function in an animal comprising administering to said animal an effective amount of a glucan having a beta-(1,3)-backbone with one or more beta-(1,3)-side chains linked thereto. |
| US08946189B2 |
Transplants
The present invention relates to a method of reducing injury to cells, a tissue or organ to be explanted from a body and upon implantation into a body by administering a composition to the cell, tissue or organ, including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and (ii) an antiarrhythmic agent. The invention also provides a composition for reducing injury to vasculature ex vivo including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and (ii) an antiarrhythmic agent. |
| US08946185B2 |
Agent for suppressing expression of dominant allele
An agent for selectively suppressing the expression of a dominant allele while allowing expression of wild-type or desired alleles and methods for using the agent are described. The RNAi agent has a structure obtained by assigning a dominant point mutation in the targeted allele as a standard point, setting a base length from the standard point to the 5′ end to a predetermined length, and introducing one mismatch base differing from the target sequence to a predetermined position downstream from the standard point. |
| US08946183B2 |
Compositions and methods for modulation of SMN2 splicing
Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy. |
| US08946179B2 |
Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided. |
| US08946178B2 |
Compositions and methods for treatment of pouchitis
The present invention relates methods of treating pouchitis by administering a pharmaceutical formulation suitable for rectal use, such as an enema or suppository, comprising an antisense oligonucleotide targeted to ICAM-1 to an individual |
| US08946176B2 |
Compositions and methods for inhibiting expression of RRM2 genes
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell. |
| US08946174B2 |
Tumor antigens BFA4 and BCY1 for prevention and / or treatment of cancer
The present invention relates to a nucleic acid encoding a polypeptide and the use of the nucleic acid or polypeptide in preventing and/or treating cancer. In particular, the invention relates to improved vectors for the insertion and expression of foreign genes encoding tumor antigens for use in immunotherapeutic treatment of cancer. |
| US08946172B2 |
Method for reducing scarring during wound healing using antisense compounds directed to CTGF
This invention provides a method for reducing hypertropic scarring resulting from dermal wound healing in a subject in need which comprises administering to the subject an antisense oligonucleotide which inhibits expression of connective tissue growth factor (CTGF) in an amount effective to inhibit expression of CTGF and thereby reduce hypertrophic scarring. |
| US08946171B2 |
Immunization of an individual against carcinomas and the preliminary stages thereof
The present invention relates to a pharmaceutical composition, comprising a cell cycle regulatory protein and/or an expressible nucleic acid coding for this in an amount suitable for immunization of an individual against carcinomas and the preliminary stages thereof and common auxiliary agents and/or to the use of a cell cycle regulatory protein and/or an expressible nucleic acid coding for this to immunize an individual against carcinomas and the preliminary stages thereof. |
| US08946170B2 |
Sustained release siRNA for ocular drug delivery
An ocular implant comprising siRNA complexed with a transfection agent selected from the group consisting of cationic lipids and short cell penetration peptides, wherein the complex is associated with a biocompatible polymer is described. The biocompatible polymer comprises a polymeric matrix configured to release the complex into the eye of a patient at therapeutic levels for a time sufficient to treat an ocular condition or disease. |
| US08946169B2 |
SPARC and methods of use thereof
The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of a mammalian tumor to a chemotherapeutic agent, comprising a means for the isolation of protein or RNA from the tumor, a SPARC protein or RNA detection and quantification means, control RNAs, and rules for predicting the response of the tumor based on the level of SPARC protein or RNA in tumor. |
| US08946166B2 |
Peptide-based compounds and compositions which inhibit muscle contraction
Peptides of general formula (I): R1-Wn-Xm-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zs-R2 their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, their preparation process, cosmetic or pharmaceutical compositions which contain them and their use in the treatment and/or care of conditions, disorders and/or diseases that are a consequence of muscle contraction. |
| US08946164B2 |
Bioactive peptide
The present invention provides a pharmaceutical or a food that comprises, as an active ingredient, at least one peptide selected from the group consisting of Val-Tyr-Leu-Pro-Arg (SEQ ID NO:1), Tyr-Leu-Pro-Arg (SEQ ID NO:2), and Leu-Pro-Arg (SEQ ID NO:3), or an analog thereof. |
| US08946162B2 |
Treatment of tumors
The invention provides for innovative improvements in tumor therapy, particularly therapies which are conducted using endogenous substances and which have no or only mild side-effects. Accordingly the present invention relates to methods of treating or preventing tumor diseases other than lung cancer comprising administering a polypeptide with an angiotensin-converting-enzyme-2 (ACE2) activity. |
| US08946161B2 |
Method of treatment using stable liquid formulation of G-CSF
Provided are pharmaceutical liquid formulations of G-CSF, which are stable over a long time period and substantially free of excipients, as well as ready-to-use syringes containing such formulations and corresponding kits. |
| US08946159B2 |
Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment
A combination therapy is provided and is directed to pharmaceutical compositions and methods for administering a combination of an α5β1 antagonist with an α2β1 antagonist to a subject. The methods are for use in inhibiting, preventing, or reversing angiogenesis, as well as in treating cancer. The compositions and methods include a combined administration of VLO4 and VP12 (ECL12). |
| US08946158B2 |
Treatments of gastrointestinal disorders
The present invention provides peptides that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms. |
| US08946155B2 |
Long-acting polypeptides and methods of producing and administering same
A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed. |
| US08946152B2 |
Method of treating parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
A method of treating Parkinson's disease in humans is disclosed, wherein glial cell-line derive neurotrophic factor (GDNF) is chronically administered directly to one or both putamen of a human in need of treatment thereof via convection-enhanced infusion using at least one implantable pump and at least one catheter. In one aspect of the present invention the GDNF is infused directly into one or both putamen through one or more indwelling intraparenchymal mutitiport brain catheters connected to one or moreimplantable pumps wherein the flow rate is pulsed. |
| US08946150B2 |
Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof
The present invention relates to novel polypeptides that bind to IL-23 receptor and inhibit the binding of IL-23 to its corresponding receptor and cell signaling thereof. The novel polypeptides of the present invention has a core structure of WX1X2X3W, where W is tryptophan, and X1, X2 and X3 are amino acids, with the proviso that when one of X1, X2 or X3 is W, the remaining two of X1, X2 or X3 cannot be W. The present invention relates a composition containing the novel polypeptides, and use of same in treating IL-23 associated human diseases including, for example, inflammatory bowel diseases, psoriasis and Crohn's disease. |
| US08946149B2 |
Use of exendin and analogs thereof to delay or prevent cardiac remodeling
The present invention relates generally to the novel use of cardioprotective incretin compounds (CICs) such as GLP-1 and exendin and agonists thereof, including analogs and derivatives to prevent, delay, attenuate, or ameliorate cardiac remodeling. The present invention relates to methods for using CICs for the treatment of conditions associated with cardiac remodeling. The present invention further relates to methods for using CICs for the reduction of the risk or severity of congestive heart failure. |
| US08946146B2 |
Method for modulating appetite
The present invention provides a method of modulating appetite and/or body weight in a subject, said method comprising administering to said subject an effective amount of a MIC-1-modulating agent, wherein said agent increases or decreases the amount of MIC-1 present in said subject, or inhibits or enhances the biological activity of MIC-1 present in said subject. |
| US08946144B2 |
Phosphonated glycopeptide and lipoglycopeptide antibiotics and uses thereof for the prevention and treatment of bone and joint infections
The present invention is directed to antimicrobial compounds which have an affinity for binding bones. More particularly, the invention is directed to phosphonated derivatives of glycopeptide or lipoglycopeptide antibiotics. These compounds are useful as antibiotics for the prevention or treatment of bone and joint infections, especially for the prevention and treatment of osteomyelitis. |
| US08946142B2 |
Beta-arrestin effectors and compositions and methods of use thereof
This application describes compounds acting as, for example, β-arrestin effectors and uses thereof, in, for example, the treatment of chronic and acute cardiovascular diseases. |
| US08946136B2 |
Hydrofluoroalcohols with improved thermal and chemical stability
Hydrofluoro alcohols of formula (I): A-(Rf)a—CFX—O—RhO—(CFX—(Rf)a*—CFX—O—RhO—)nH in which: Rh is a hydrocarbon-based chain; X is F or a C1-C6 (per)fluoroalkyl; a or a* is 0 or 1; Rf is a (per)fluoro(poly)oxyalkylene chain or a (per)fluoroalkyl chain; A is selected from the group consisting of —F, —Cl, and —H (possible only when a=1) or is HO—Rh—O—CFX—; n is an integer from 0 to 200, with the condition that n=0 when A is selected from the group consisting of —F, —Cl, and —H. |
| US08946134B2 |
Grease composition, grease-packed bearing, universal joint for propeller shaft, lubricating oil composition, and oil-impregnated sintered bearing
The present invention provides a grease composition or a lubricating oil composition which is capable of effectively preventing hydrogen brittleness-caused peeling from occurring on a rolling surface of a rolling bearing, is excellent in durability in a high temperature and speed operation, and can be used for a long time. A grease-packed bearing (1) has an inner ring (2), an outer ring (3), and a plurality of rolling elements (4). A sealing member (6) for sealing a grease composition (7) is provided at openings (8a) and (8b) disposed at both axial ends of the inner ring (2) and the outer ring (3). The grease composition (7) includes a base grease composed of a base oil and a thickener and an additive added to the base grease. The additive contains at least one compound selected from among plant-derived polyphenolic compounds and compounds formed by decomposition thereof. The above-described compounds include tannin, gallic acid, ellagic acid, chlorogenic acid, caffeic acid, curcumin, quercetin, and quinic acid. |
| US08946130B2 |
Methods for increase gas production and load recovery
Methods are disclosed for improved sand control, fines control, load recovery and well productivity, where the compositions comprise reaction products of an amine and a phosphate-containing compound. |
| US08946129B2 |
Mass labels
Provided is a set of mass labels, each mass label in the set comprising a mass marker moiety attached via a cleavable linker to a mass normalization moiety, each mass label in the set having a common mass; wherein the set comprises a plurality of groups of mass labels, the mass of the mass marker moiety being the same for mass labels within a group, the mass of the mass marker moiety being different between groups; the mass marker moiety is capable of fragmentation into two or three fragments; and the mass of at least one fragment of the mass marker moiety differs between mass labels within a group. |
| US08946128B2 |
Signal sequence-independent pIX phage display
The present invention provides an alternative scaffold for peptides displayed on filamentous phages through novel fusion proteins primarily originating from pIX. Libraries of filamentous phages can be created from fusion proteins, and a phage display system comprising a phagemid and a helper phage is a part of the invention. An aspect of the invention is a kit containing a phage display system comprising a phagemid that contains a nucleic acid encoding the fusion protein of the invention and a helper phage. |
| US08946125B2 |
Connection structure for superconductive cables, method for laying the same, and method for vacuuming connection structure for superconductive cables
A thermal insulation tube has a double-structure including a thermal insulation internal tube and a thermal insulation external tube, an intermediate connecting part has a double-structure including an outer container and an inner container, the internal tube and the external tube penetrate through a wall surface of the outer container and are introduced at least up to a wall surface of the inner container, a region between the internal tube and the external tube is sealed by joining an end to be introduced of the internal tube and an end to be introduced of the external tube, at an introduction portion of the external tube to be positioned on an inner side of a wall surface of the outer container, and a corrugated tubular part has a tube wall thinner than the external tube outside of the wall surface. |
| US08946123B2 |
Compositions and methods for controlling the direction of growth of plants with rootlets
Described herein are compositions including an herbicide, a capsaicinoid, and an acrylic for controlling the direction of growth of plants with rootlets. Also described herein are methods for making and using the compositions. |
| US08946122B2 |
Pesticidal combinations
Stabilized liquid agrochemical compositions are provided which comprise flowable non-aqueous dispersion concentrates comprising a continuous substantially water-miscible liquid phase, a dispersed water-immiscible liquid phase, and a colloidal solid. In one embodiment, the dispersed phase comprises at least one water-sensitive agrochemically active ingredient and the colloidal solid is disposed at the interface between the dispersed phase and the continuous phase. In another embodiment, the water-sensitive agrochemically active ingredient is a solid but is dissolved in an oily liquid present in the dispersed phase, or is a solid and is dispersed within the dispersed phase, or is a solid complex of an agrochemical with a molecular complexing agent and is dispersed within the dispersed phase. The compositions of the invention can be used directly or with dilution to combat pests or as plant growth regulators. |
| US08946119B2 |
Chitooligosaccharides and methods for use in enhancing soybean growth
Disclosed are methods of enhancing growth of soybean plants, comprising treating soybean seed or the soybean plant that germinates from the seed with an effective amount of at least one chitooligosaccharide, wherein upon harvesting the soybean plant exhibits at least one of increased plant yield measured in terms of bushels/acre, increased root number, increased root length, increased root mass, increased root volume and increased leaf area, compared to untreated soybean plants or soybean plants harvested from untreated soybean seed. |
| US08946118B2 |
Removal of hydrophobic contaminants
Compositions and methods are disclosed for remediating environmental contaminants when such contaminants primarily include hydrophobic materials such as petroleum. |
| US08946117B2 |
Spherical catalyst supports
There is presented a catalyst support that has a substantially spherical body, penetrated with a plurality of tunnels extending from a first end on a surface location of the catalyst body to another end on another surface location of the body. The support is made of alumina or like composition. The catalyst body has a total surface that includes the outer surface and surfaces within the tunnels. This total surface is adapted to receive catalyst composition. The catalyst support is adapted to being packed in a reactor and provides lower packed bed pressure drop. |
| US08946112B2 |
Photocatalytic material for splitting oxides of carbon
An embodiment relates to a photocatalytic composite material comprising (a) a first component that generates a photoexcited electron and has at least a certain minimum bandgap to absorb visible light and a structure that substantially prevents the recombination of the photoexcited electron and a hole; (b) a second component that adsorbs/absorbs an oxide of carbon; and (c) a third component that splits the oxide of carbon into carbon and oxygen using the photoexcited electron. |
| US08946111B2 |
Fibrous composite catalytic structure having at least three solid phases
Permeable composite fibrous catalytic sheets comprised of at least three distinct solid phases. A first solid phase is a 3-dimensional porous network of a non-conductive porous ceramic material. A second solid phase is an electrically conductive phase comprised of randomly oriented electrically conductive fibers. A third phase is comprised of catalytic particles dispersed on said 3-dimensional porous network, said conductive fibers, or both. A fourth phase can be present, which fourth phase is comprised one or more conductive species or one or more non conductive species embedded in said first solid phase. |
| US08946105B2 |
Methods for removing iron material from a substrate
Methods of removing iron from a catalytic converter having an accumulation of one or more iron compounds and regenerating a catalytic converter are provided. A catalytic converter having an accumulation of one or more iron compounds embedded or deposited thereon can be treated with a substantially aqueous alkaline solution in which the substantially aqueous alkaline solution includes an antioxidant. |
| US08946104B2 |
Dielectric ceramic, method of manufacturing dielectric ceramic, and multilayer ceramic capacitor
A dielectric ceramic whose primary component is an ABO3 compound (A contains Ba and B contains Ti) has a per-layer thickness of approx. 0.5 μm or less, where the volume ratio to all dielectric sintered grains of those whose grain size is in a range of 0.02 μm to 0.15 μm is adjusted to a grain size distribution of 1% to 10%. High dielectric constant and high reliability can be achieved at the same time with the dielectric ceramic. |
| US08946102B2 |
Copper red frits and pigments comprising silica and at least one of cupric oxide and cuprous oxide
This invention relates to lead free and cadmium free copper-containing glass fits that can be used as pigments to color other glass fits or to impart color to solid substrates such as glass, ceramic or metals, or to impart color to a thermoplastic mass. The compositions comprise silica, alkali metal oxides, alkaline earth metal oxides, tin oxide and copper oxide. The resulting compositions can be used to decorate and protect automotive, beverage, architectural, pharmaceutical and other glass substrates, generally imparting a red color. |
| US08946098B2 |
Device for a laser lift-off method and laser lift-off method
A device is intended for a laser lift-off method to sever at least one layer from a carrier. The device includes a laser that generates pulsed laser radiation and at least one beam splitter. The laser radiation is divided into at least two partial beams by the at least one beam splitter. The partial beams are superimposed in an irradiation plane, the irradiation plane being provided such that a major side of the carrier remote from the layer is arranged therein. At the irradiation plane, an angle (α) between the at least two partial beams is at least 1.0°. |
| US08946095B2 |
Method of forming interlayer dielectric film above metal gate of semiconductor device
A method of forming an interlayer dielectric film above a metal gate of a metal oxide semiconductor device comprises forming a metal gate above a semiconductor substrate; and forming the interlayer dielectric film above the metal gate by reacting a silicon-containing compound as precursor and a reactant for oxidizing the silicon-containing compound. The silicon-containing compound has the formula: Six(A)y(B)z(C)m(D)n (I) wherein x is in the range of from 1 to 9; y+z+m+n is in the range of from 4 to 20; and A, B, C, and D independently represent a functional group connecting with a silicon atom. The functional group is selected from a group consisting of alkyl, alkenyl, alkynyl, aryl, alkylaryl, alkoxyl, alkylcarbonyl, carboxyl, alkylcarbonyloxy, amide, amino, alkylcarbonylamino, —NO2, and —CN. |
| US08946093B2 |
Imprint method, imprint apparatus, and method of manufacturing semiconductor device
In an imprint method of an embodiment, in the imprinting of an imprint shot including an outermost peripheral region of a substrate where resist is not desired to be entered at the time of imprinting, light curing the resist is applied to a light irradiation region with a predetermined width including a boundary between the outermost peripheral region and a pattern formation region more inside than the outermost peripheral region, whereby the resist which is to enter inside the outermost peripheral region is cured. Then, light curing the resist filled in a template pattern is applied onto a template. |
| US08946091B2 |
Prevention of line bending and tilting for etch with tri-layer mask
A method for etching features in an etch layer is provided. An organic mask layer is etched, using a hard mask as an etch mask. The hard mask is removed, by selectively etching the hard mask with respect to the organic mask and etch layer. Features are etched in the etch layer, using the organic mask as an etch mask. |
| US08946086B2 |
Methods of forming patterns, and methods of forming integrated circuitry
Some embodiments include methods of forming a pattern. First lines are formed over a first material, and second lines are formed over the first lines. The first and second lines form a crosshatch pattern. The first openings are extended through the first material. Portions of the first lines that are not covered by the second lines are removed to pattern the first lines into segments. The second lines are removed to uncover the segments. Masking material is formed between the segments. The segments are removed to form second openings that extend through the masking material to the first material. The second openings are extended through the first material. The masking material is removed to leave a patterned mask comprising the first material having the first and second openings therein. In some embodiments, spacers may be formed along the first and second lines to narrow the openings in the crosshatch pattern. |
| US08946085B2 |
Semiconductor process and structure
A semiconductor process includes the following steps. Firstly, a conductive substrate is provided. Then, at least one insulating pattern is formed on the conductive substrate. Thereafter at least one metal pattern is formed on the insulating pattern. After that, a passivation layer is formed on the conductive substrate to cover the metal pattern by an electroplating process. |
| US08946080B2 |
Pattern transfer method
In one embodiment, a pattern transfer method includes forming a photoreactive resin on a substrate to be processed. The method further includes pressing a mold against the photoreactive resin, the mold including a transparent substrate having a concave-convex pattern, and a light-blocking film provided on a part of surfaces of the concave-convex pattern. The method further includes irradiating the photoreactive resin with light through the mold in a state in which the mold is pressed against the photoreactive resin. The method further includes baking the photoreactive resin in a state in which the mold is pressed against the photoreactive resin after irradiating the photoreactive resin with the light. The method further includes releasing the mold from the photoreactive resin after baking the photoreactive resin. The method further includes rinsing the photoreactive resin with a rinsing solution after releasing the mold. |
| US08946079B2 |
Semiconductor construct and manufacturing method thereof as well as semiconductor device and manufacturing method thereof
A semiconductor construct includes a semiconductor substrate and connection pads provided on the semiconductor substrate. Some of the connection pads are connected to a common wiring and at least one of the remaining of the connection pads are connected to a wiring. The construct also includes a first columnar electrode provided to be connected to the common wiring and a second columnar electrode provided to be connected to a connection pad portion of the wiring. |
| US08946074B2 |
Method of making interconnect structure
A method of forming a semiconductor device, comprising: providing a Si-containing layer; forming a barrier layer over said Si-containing layer, said barrier layer comprising a compound including a metallic element; forming a metallic nucleation_seed layer over said barrier layer, said nucleation_seed layer including said metallic element; and forming a metallic interconnect layer over said nucleation_seed layer, wherein said barrier layer and said nucleation_seed layer are formed without exposing said semiconductor device to the ambient atmosphere. |
| US08946072B2 |
No-flow underfill for package with interposer frame
Mechanisms of forming a package on package (PoP) package by using an interposer and an no-reflow underfill (NUF) layer are provided. The interposer frame improves the form factor of the package, enables the reduction in the pitch of the bonding structures. The NUF layer enables a semiconductor die and an interposer frame be bonded to a substrate by utilizing the heat on the connectors of the semiconductor die and on the connectors of the interposer frame for bonding. The heat provided by the semiconductor die and the interposer frame also transforms the NUF layer into an underfill. PoP structures formed by using the interposer frame and the NUF layer improve yield and have better reliability performance. |
| US08946070B2 |
Four terminal transistor fabrication
Producing a transistor includes providing a substrate including in order a first electrically conductive material layer positioned on the substrate and a first electrically insulating material layer positioned on the first electrically conductive material layer. A gate including a reentrant profile is formed from an electrically conductive material layer stack provided on the first electrically insulating material layer in which a first portion of the gate is sized and positioned to extend beyond a second portion of the gate. The gate including the reentrant profile and at least a portion of the first electrically insulating material layer are conformally coated with a second electrically insulating material layer. The second electrically insulating material layer is conformally coated the with a semiconductor material layer. A source and drain electrodes are formed simultaneously by directionally depositing a second electrically conductive material layer on portions of the semiconductor material layer. |
| US08946068B2 |
Patterned doping of semiconductor substrates using photosensitive monolayers
A semiconductor device and a method of fabricating a semiconductor device are disclosed. Embodiments of the invention use a photosensitive self-assembled monolayer to pattern the surface of a substrate into hydrophilic and hydrophobic regions, and an aqueous (or alcohol) solution of a dopant compound is deposited on the substrate surface. The dopant compound only adheres on the hydrophilic regions. After deposition, the substrate is coated with a very thin layer of oxide to cap the compounds, and the substrate is annealed at high temperatures to diffuse the dopant atoms into the silicon and to activate the dopant. In one embodiment, the method comprises providing a semiconductor substrate including an oxide surface, patterning said surface into hydrophobic and hydrophilic regions, depositing a compound including a dopant on the substrate, wherein the dopant adheres to the hydrophilic region, and diffusing the dopant into the oxide surface of the substrate. |
| US08946062B2 |
Polycrystalline silicon thick films for photovoltaic devices or the like, and methods of making same
A method of manufacturing a polycrystalline silicon film includes: depositing a catalyst layer including nickel and depositing nickel nanoparticles on a substrate; exposing the catalyst layer and the nanoparticles to at least silane gas; and heat treating the substrate coated with the catalyst layer and the nanoparticles during at least part of the exposing to silane gas in growing a silicon based film on the substrate. |
| US08946058B2 |
Method and apparatus for plasma dicing a semi-conductor wafer
The present invention provides a method for plasma dicing a substrate, the method comprising providing a process chamber having a wall; providing a plasma source adjacent to the wall of the process chamber; providing a work piece support within the process chamber; placing a work piece onto the work piece support, said work piece having a support film, a frame and the substrate; loading the work piece onto the work piece support; applying a tensional force to the support film; clamping the work piece to the work piece support; generating a plasma using the plasma source; and etching the work piece using the generated plasma. |
| US08946055B2 |
Laser processing method for cutting substrate and laminate part bonded to the substrate
A laser processing method is provided, which, even when a substrate formed with a laminate part including a plurality of functional devices is thick, can cut the substrate and laminate part with a high precision.This laser processing method irradiates a substrate 4 with laser light L while using a rear face 21 as a laser light entrance surface and locating a light-converging point P within the substrate 4, so as to form modified regions 71, 72, 73 within the substrate 4. Here, the HC modified region 73 is formed at a position between the segmented modified region 72 closest to the rear face 21 and the rear face 21, so as to generate a fracture 24 extending along a line to cut from the HC modified region 73 to the rear face 21. Therefore, when an expandable tape is bonded to the rear face 21 of the substrate 4 and expanded, fractures smoothly advance from the substrate 4 to a laminate part 16 by way of the segmented modified regions 72, whereby the substrate 4 and laminate part 16 can be cut along the line to cut with a high precision. |
| US08946051B2 |
Method for manufacturing SOI substrate and method for manufacturing semiconductor device
It is an object to provide a method for manufacturing an SOI substrate in which crystal defects of a single crystal semiconductor layer are reduced even when a single crystal semiconductor substrate in which crystal defects exist is used. Such an SOI substrate can be manufactured through the steps of forming a single crystal semiconductor layer which has an extremely small number of defects over a single crystal semiconductor substrate by an epitaxial growth method; forming an oxide film on the single crystal semiconductor substrate by thermal oxidation treatment; introducing ions into the single crystal semiconductor substrate through the oxide film; bonding the single crystal semiconductor substrate into which the ions are introduced and a semiconductor substrate to each other; causing separation by heat treatment; and performing planarization treatment on the single crystal semiconductor layer provided over the semiconductor substrate. |
| US08946050B2 |
Double trench well formation in SRAM cells
A method is provided for forming SRAM cells with low energy implants. Embodiments include forming deep trenches in a silicon substrate; forming a deep n-well or deep p-well around a bottom of each deep trench; filling the deep trenches with oxide; forming a first or second shallow trench between each pair of adjacent deep trenches; forming a first p-well or first n-well, respectively, above each deep n-well or p-well; forming a second n-well at a bottom of each first shallow trench; forming a p+ region above each second n-well on each side of each first shallow trench; filling the first shallow trenches with oxide; forming a second p-well at a bottom of each second shallow trench; filling the second shallow trenches with oxide; forming a p+ region above each second n-well on each side of each first shallow trench; and forming an n+ region above each second p-well. |
| US08946045B2 |
Metal-insulator-metal (MIM) capacitor with deep trench (DT) structure and method in a silicon-on-insulator (SOI)
A structure forming a metal-insulator-metal (MIM) trench capacitor is disclosed. The structure comprises a multi-layer substrate having a metal layer and at least one dielectric layer. A trench is etched into the substrate, passing through the metal layer. The trench is lined with a metal material that is in contact with the metal layer, which comprises a first node of a capacitor. A dielectric material lines the metal material in the trench. The trench is filled with a conductor. The dielectric material that lines the metal material separates the conductor from the metal layer and the metal material lining the trench. The conductor comprises a second node of the capacitor. |
| US08946039B2 |
Polysilicon resistor formation
Aspects of the present invention relate to an approach for implanting and forming a polysilicon resistor with a single implant dose. Specifically, a mask having a set of openings is formed over a resistor surface. The set of openings are typically formed in a column-row arrangement according to a predetermined pattern. Forming the mask in this manner allows the resistor surface to have multiple regions/zones. A first region is defined by the set of openings in the mask, and a second region is defined by the remaining portions of the mask. The resistor is then subjected to a single implant dose via the openings. Implanting the resistor in this manner allows the resistor to have multiple resistance values (i.e., a first resistance value in the first region, and a second resistance value in the second region). |
| US08946037B2 |
Methods for producing a tunnel field-effect transistor
A method for producing a tunnel field-effect transistor is disclosed. Connection regions of different doping types are produced by means of self-aligning implantation methods. |
| US08946032B2 |
Method of manufacturing power device
A power device manufacturing method is provided. The power device manufacturing method may perform patterning of regions on which a source electrode and a drain electrode are to be formed, may regrow n+-gallium nitride (GaN) and p+-GaN in the patterned regions and thus, a thin film crystal may not be damaged. Also, a doping concentration of n+-GaN or p+-GaN may be adjusted, an ohmic resistance in the source electrode region and the drain electrode region may decrease, and a current density may increase. The power device manufacturing method may regrow n+-GaN and p+-GaN at a high temperature after an n-GaN layer and a p-GaN layer are patterned. Accordingly, a thin film crystal may not be damaged and thus, a reliability may be secured, and an annealing process may not be additionally performed and thus, a process may be simplified and a cost may be reduced. |
| US08946026B2 |
Methods of fabricating a semiconductor device including metal gate electrodes
A method of fabricating semiconductor devices having metal gate electrodes includes forming an insulating layer on a semiconductor substrate having a first region and a second region. The insulating layer is formed to include an interlayer insulating layer and a gate insulation layer. The interlayer insulating layer has first and second grooves respectively disposed in the first and second regions, and the gate insulation layer covers at least bottom surfaces of the first and second grooves. A laminated metal layer is formed on the substrate having the insulating layer. A planarization layer having non-photo sensitivity is formed on the laminated metal layer. The planarization layer in the first region is selectively removed using a dry etching process to expose the laminated metal layer in the first region and to form a planarization layer pattern covering the laminated metal layer in the second region. |
| US08946022B2 |
Integrated nanostructure-based non-volatile memory fabrication
Nanostructure-based charge storage regions are included in non-volatile memory devices and integrated with the fabrication of select gates and peripheral circuitry. One or more nanostructure coatings are applied over a substrate at a memory array area and a peripheral circuitry area. Various processes for removing the nanostructure coating from undesired areas of the substrate, such as target areas for select gates and peripheral transistors, are provided. One or more nanostructure coatings are formed using self-assembly based processes to selectively form nanostructures over active areas of the substrate in one example. Self-assembly permits the formation of discrete lines of nanostructures that are electrically isolated from one another without requiring patterning or etching of the nanostructure coating. |
| US08946021B2 |
Nonvolatile semiconductor memory device and method for manufacturing the same
On a silicon substrate is formed a stacked body by alternately stacking a plurality of silicon oxide films and silicon films, a trench is formed in the stacked body, an alumina film, a silicon nitride film and a silicon oxide film are formed in this order on an inner surface of the trench, and a channel silicon crystalline film is formed on the silicon oxide film. Next, a silicon oxide layer is formed at an interface between the silicon oxide film and the channel silicon crystalline film by performing thermal treatment in an oxygen gas atmosphere. |
| US08946016B2 |
Replacement gates to enhance transistor strain
Some embodiments of the present invention include apparatuses and methods relating to NMOS and PMOS transistor strain. |
| US08946014B2 |
FinFET device structure and methods of making same
Embodiments of the present disclosure are a method of forming a semiconductor device, a method of forming a FinFET device, a FinFET device. An embodiment a method for semiconductor device, the method comprising forming a first dielectric layer over a substrate, forming a first hardmask layer over the first dielectric layer, and patterning the first hardmask layer to form a first hardmask portion with a first width. The method further comprises forming a first raised portion of the first dielectric layer with the first width, wherein the first raised portion is aligned with the first hardmask portion, and forming a first spacer and a second spacer over the first dielectric layer, wherein the first spacer and the second spacer are on opposite sides of the first raised portion, and wherein the sidewalls of the first spacer and the second spacer are substantially orthogonal to the top surface of the substrate. |
| US08946012B2 |
Method of forming a semiconductor structure
A method of forming a semiconductor structure having a substrate is disclosed. The semiconductor structure includes a first layer formed in contact with the substrate. The first layer made of a first III-V semiconductor material selected from GaN, GaAs and InP. A second layer is formed on the first layer. The second layer made of a second III-V semiconductor material selected from AlGaN, AlGaAs and AlInP. An interface is between the first layer and the second layer forms a carrier channel. An insulating layer is formed on the second layer. Portions of the insulating layer and the second layer are removed to expose a top surface of the first layer. A metal feature is formed in contact with the carrier channel and the metal feature is annealed to form a corresponding intermetallic compound. |
| US08946010B2 |
Three dimensional FET devices having different device widths
A method of manufacturing a three dimensional FET device structure includes: providing a substrate having a semiconductor layer on an insulator layer; forming three dimensional fins in the semiconductor layer; applying a masking material to a first fin while exposing a second fin; applying a hydrogen atmosphere to the substrate and exposed second fin, the hydrogen atmosphere causing the exposed second fin to reflow and change shape; removing the masking material from the first fin; and forming a gate to wrap around each of the first and second fins. The first and second fins are formed having a device width such that the first fin having a first device width and a second fin having a second device width with the first device width being different than the second device width. |
| US08946007B2 |
Inverted thin channel mosfet with self-aligned expanded source/drain
After formation of a gate electrode, a source trench and a drain trench are formed down to an upper portion of a bottom semiconductor layer having a first semiconductor material of a semiconductor-on-insulator (SOI) substrate. The source trench and the drain trench are filled with at least a second semiconductor material that is different from the first semiconductor material to form source and drain regions. A planarized dielectric layer is formed and a handle substrate is attached over the source and drain regions. The bottom semiconductor layer is removed selective to the second semiconductor material, the buried insulator layer, and a shallow trench isolation structure. The removal of the bottom semiconductor layer exposes a horizontal surface of the buried insulator layer present between source and drain regions on which a conductive material layer is formed as a back gate electrode. |
| US08946006B2 |
Replacement gate MOSFET with raised source and drain
A disposable dielectric spacer is formed on sidewalls of a disposable material stack. Raised source/drain regions are formed on planar source/drain regions by selective epitaxy. The disposable dielectric spacer is removed to expose portions of a semiconductor layer between the disposable material stack and the source/drain regions including the raised source/drain regions. Dopant ions are implanted to form source/drain extension regions in the exposed portions of the semiconductor layer. A gate-level dielectric layer is deposited and planarized. The disposable material stack is removed and a gate stack including a gate dielectric and a gate electrode fill a cavity formed by removal of the disposable material stack. Optionally, an inner dielectric spacer may be formed on sidewalls of the gate-level dielectric layer within the cavity prior to formation of the gate stack to tailor a gate length of a field effect transistor. |
| US08946004B2 |
Contact portion of wire and manufacturing method thereof
A contact portion of wiring and a method of manufacturing the same are disclosed. A contact portion of wiring according to an embodiment includes: a substrate; a conductive layer disposed on the substrate; an interlayer insulating layer disposed on the conductive layer and having a contact hole; a metal layer disposed on the conductive layer and filling the contact hole; and a transparent electrode disposed on the interlayer insulating layer and connected to the metal layer, wherein the interlayer insulating layer includes a lower insulating layer and an upper insulating layer disposed on the lower insulating layer, the lower insulating layer is undercut at the contact hole, and the metal layer fills in the portion where the lower insulating layer is undercut. |
| US08946003B2 |
Method of forming transistors with ultra-short gate feature
A semiconductor transistor is formed as follows. A gate electrode is formed over but is insulated from a semiconductor body region. A first layer of insulating material is formed over the gate electrode and the semiconductor body region. A second layer of insulating material different from the first layer of insulating material is formed over the first layer of insulating material. Only the second layer of insulating material is etched to form spacers along the side-walls of the gate electrode. Impurities are implanted through the first layer of insulating material to form a source region and a drain region in the body region. A substantial portion of those portions of the first layer of insulting material extending over the source and drain regions is removed. |
| US08946002B2 |
Method of forming a semiconductor device having a patterned gate dielectric and structure therefor
In one embodiment, a semiconductor device includes an isolated trench-electrode structure. The semiconductor device is formed using a modified photolithographic process to produce alternating regions of thick and thin dielectric layers that separate the trench electrode from regions of the semiconductor device. The thin dielectric layers can be configured to control the formation channel regions, and the thick dielectric layers can be configured to reduce switching losses. |
| US08945991B2 |
Fabricating a wafer level semiconductor package having a pre-formed dielectric layer
There are disclosed herein various implementations of improved wafer level semiconductor packages. One exemplary implementation comprises forming a post-fabrication redistribution layer (post-Fab RDL) between first and second dielectric layers affixed over a surface of a wafer, and forming a window for receiving an electrical contact body in the second dielectric layer, the window exposing the post-Fab RDL. At least one of the first and second dielectric layers is a pre-formed dielectric layer, which may be affixed over the surface of the wafer using a lamination process. In one implementation, the window is formed using a direct laser ablation process. |
| US08945989B2 |
Stiffened semiconductor die package
A stiffened semiconductor die package has a semiconductor die including an integrated circuit. The die has an active side with die bonding pads and an opposite inactive side. A conductive frame that acts as a ground plane surrounds all edges of the die and a mold compound covers the conductive frame and the edges of the die. A thermally conductive sheet is attached to the inactive side of the die. A dielectric support structure with external connector pads with solder deposits is attached to the active side of the die. The external connector pads are selectively electrically coupled to the die bonding pads. |
| US08945988B2 |
Method for thinning, metalizing, and dicing a semiconductor wafer and, semiconductor device made using the method
There is provided a method of fabricating a semiconductor device, method including: a) forming semiconductor elements in plural element regions surrounded by assumed dicing lines on a first principal surface of a semiconductor wafer; b) grinding the second principal surface in such a way that an outer peripheral portion of a second principal surface on the opposite side of the first principal surface of the semiconductor wafer becomes thicker than an inner peripheral portion of the second principal surface; c) forming a metal film, in such a way as to avoid sections corresponding to the dicing lines, on the second principal surface that has been ground in the grinding step; and d) cutting the semiconductor wafer from the second principal surface side along portions where the metal film is not formed on the dicing lines. |
| US08945978B2 |
Formation of metal structures in solar cells
A metal contact of a solar cell is formed by electroplating copper using an electroplating seed that is formed on a dielectric layer. The electroplating seed includes an aluminum layer that connects to a diffusion region of the solar cell through a contact hole in the dielectric layer. A nickel layer is formed on the aluminum layer, with the nickel layer-aluminum layer stack forming the electroplating seed. The copper is electroplated in a copper plating bath that has methanesulfonic acid instead of sulfuric acid as the supporting electrolyte. |
| US08945970B2 |
Assembling and applying nano-electro-mechanical systems
A method of constructing devices using semiconductor manufacturing processes includes fabricating a device having a movable portion and a fixed portion. The movable portion is connected to the fixed portion only through at least one sacrificial layer. The sacrificial layer is removed in the presence of a force of sufficient strength so as to controllably reposition the movable portion during the release process. The force can be externally applied, generated locally as a result of, for example, the relative positions of the fixed and movable portions, or some combination of the two. Several devices constructed according to such a method are also disclosed. |
| US08945962B2 |
Thin film transistor, display device having thin film transistor, and method for manufacturing the same
In a method for manufacturing a semiconductor device including a transistor and a conductive film over a substrate, a first insulating film and a second insulating film are formed over the transistor and the conductive film sequentially. Then, an opening and a recessed portion are formed in the second insulating film using one multi-tone photomask, wherein the opening is deeper than the recessed portion in the second insulating film. By using the opening, a first contact hole exposing one of the electrodes of the transistor is formed through the first and second insulating films and, by using the recessed portion, a second contact hole exposing the first insulating film is formed through the second insulating film. Moreover, an electrode is formed on and in contact with the one of the electrodes in the first contact hole and the first insulating film in the second contact hole. |
| US08945959B2 |
LED with thin package struture and method for manufacturing the same
A method for manufacturing an LED (light emitting diode) is disclosed wherein a metal substrate is provided. A chip fastening area with a depression and two wire fixing areas on the first metal substrate are defined on the metal substrate. The chip fastening area and the wire fixing areas are separated by a plurality of first grooves. An LED chip is provided in the depression of the chip fastening area and electrically connected to the wire fixing areas by wires. An encapsulant is formed to cover and connect the chip fastening area and the wire fixing areas. Portions of the metal substrate except the chip fastening area and the wire fixing areas are removed. |
| US08945958B2 |
Methods for manufacturing light emitting diode and light emitting device
The present invention provides manufacturing methods of an LED and a light emitting device. The manufacturing method of the LED includes: providing a substrate; forming on the substrate an LED chip and a second electrode successively; forming a lens structure covering the second electrode; coating the lens structure with fluorescent powder; forming a plurality of evenly distributed contact holes on a backface of the substrate, the contact holes extending through the substrate and to the LED chip; and filling the contact holes with conducting material till the backface of the substrate is covered by the conducting material. The LED has a high luminous efficiency and the manufacturing method is easy to implement. |
| US08945957B2 |
Method of manufacturing liquid ejection head
The method of manufacturing a liquid ejection head includes: forming a first protective layer on one surface of the substrate; forming the wiring layer on another surface of the substrate; forming the insulating layer on the wiring layer, and then partially removing the insulating layer to partially expose the wiring layer; forming the electrode pad on an exposed portion of the wiring layer; forming a flow path member on the another surface of the substrate; forming a second protective layer on the one surface of the substrate after the formation of the flow path member; and partially removing at least one of the first protective layer and the second protective layer, and then forming the supply port leading from the one surface of the substrate to the another surface of the substrate. |
| US08945950B2 |
STT-MRAM cell structures
A magnetic cell structure including a nonmagnetic bridge, and methods of fabricating the structure are provided. The magnetic cell structure includes a free layer, a pinned layer, and a nonmagnetic bridge electrically connecting the free layer and the pinned layer. The shape and/or configuration of the nonmagnetic bridge directs a programming current through the magnetic cell structure such that the cross sectional area of the programming current in the free layer of the structure is less than the cross section of the structure. The decrease in the cross sectional area of the programming current in the free layer enables a lower programming current to reach a critical switching current density in the free layer and switch the magnetization of the free layer, programming the magnetic cell. |
| US08945948B2 |
Integrated electronic assembly for conserving space in a circuit
An integrated electronic assembly including a first electronic component defining a receptacle and at least a second electronic component wherein at least a portion of the second electronic component is disposed in the receptacle of the first electronic component, and a method for conserving space in a circuit or on a printed circuit board by integrating a plurality of electronic components so that the plurality of electronic components collectively take up a smaller amount of space on a substrate than the plurality of electronic components would if the plurality of electronic components were not integrated. |
| US08945941B2 |
Tissue sample preparation and MALDI MS imaging thereof
Aspects of the present invention relate to a method for the preparation of samples for MALDI MS imaging. Certain embodiments relate to a method of matrix deposition for samples, wherein tissue sections are prepared via a synergistic combination of fixation with matrix. In certain embodiments, tissue is fixed with cold solvent, according to well-established histology protocols, and in the presence of matrix, allowing for high resolution spatial mapping of protein, lipid, sugar, and/or nucleic acid distribution. In certain embodiments, the present invention relates to fixation with matrix of whole organisms. In certain embodiments, animals are perfused with fixation and matrix mixtures, which allows for direct mass spectrometry analysis. |
| US08945939B2 |
Control over hydrogen fluoride levels in oxide etchant
The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe. |
| US08945938B2 |
Composition, device and method for colorimetric detection of an analyte using imprinted polymers and photochromic switch molecules
The invention provides various compositions, devices, and methods useful for detecting an analyte by colorimetric readout. The compositions and devices include polymers constructed to have pores specifically imprinted to provide for capture of an analyte in the pores; nanoparticles layered on the polymers; and photochromic optical switch molecules coated on the nanoparticles. Capture of the analyte in the pores of the polymer results in a change in the spatial relation of the nanoparticles layered on the polymer, which in turn causes the photochromic optical switch molecules coated thereon to undergo a change in energy state corresponding to a visible change in the optical spectra of the photochromic optical switch molecules. |
| US08945937B2 |
Apparatus and method for analyzing graphene and graphene boundary
A method of analyzing graphene includes providing a first graphene structure including graphene having grains and grain boundaries, and a support portion for supporting the graphene, generating a second graphene structure by oxidizing the first graphene structure, and detecting a shape of the graphene. |
| US08945936B2 |
Measuring chemical properties of a sample fluid in dialysis systems
In one aspect of the invention, a method includes determining an amount of carbon dioxide (CO2) in dialysate flowing through a dialysis system using a CO2 sensor associated with the dialysis system, determining, using a pH sensor associated with the dialysis system, a pH level of the dialysate, and calculating a level of bicarbonate in the dialysate based at least in part on the determined amount of CO2 measured in the gas and the determined pH level of the dialysate. |
| US08945929B2 |
Marker for determination of sensitivity to anti-cancer agent
Provided are a marker for determining sensitivity to an anticancer agent capable of distinguishing a therapeutic response of an individual patient and a novel means for a cancer therapy using the marker. The marker for determining sensitivity to an anticancer agent contains a substance in a metabolic pathway in which L-phenylalanine and/or N,N-dimethyl glycine are/is involved. |
| US08945926B2 |
Expanding the eukaryotic genetic code
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided. |
| US08945922B2 |
Generating a mature NKT cell from a reprogrammed somatic cell with a T-cell antigen receptor α-chain region rearranged to uniform Va-Ja in a NKT-cell specific way
Provided are an iPS cell derived from a somatic cell such as an NKT cell, having the α-chain region of the T cell antigen receptor gene rearranged to uniform Vα-Jα in an NKT cell receptor-specific way, NKT cells differentiated from the iPS cell, a method of creating the same, and an immune cell therapy agent prepared using cells differentiated from the iPS cell. Also provided are an iPS cell having TCRα rearranged to NKT-TCR (NKT-iPS cell), obtained by contacting a somatic cell, such as an NKT cell, having the α-chain region of the T cell antigen receptor gene rearranged to uniform Vα-Jα in an NKT cell receptor-specific way, with nuclear reprogramming factors, isolated NKT cells obtained by differentiating the iPS cell ex vivo (iPS-NKT cell), a method of generating CD4/CD8-double positive NKT cells (DP-NKT cells) and mature NKT cells from NKT-iPS cells by altering the combination of feeder cells and/or cytokines, a method of expanding the iPS-NKT cells, and an NKT cell cytotherapy agent comprising NKT cells activated with α-galactosyl ceramide (α-GalCer), or iPS-NKT cells, and α-GalCer in combination. |
| US08945919B2 |
Methods and composition for treating neural degeneration
Disclosed herein are methods and compositions for the use of marrow adherent stem cells and their descendents; e.g., bone marrow-derived neural regenerating cells; in the treatment of various neurodegenerative disorders. In certain embodiments, bone marrow-derived neural regenerating cells transplanted to sites of neural degeneration stimulate growth and/or survival of host neurons. |
| US08945915B2 |
Energy production systems utilizing ruminant animal methane emissions
A process for the utilization of the methane produced by enteric fermentation, specifically to a process that utilizes methane produced by ruminant animals through enteric fermentation as a source of carbon and/or energy for the directed production of methane-based goods or processes is provided. |
| US08945907B2 |
Genetically engineered recombinant Escherichia coli producing L-tryptophan having originally L-phenylalanine productivity, and method for producing L-tryptophan using the microorganism
The present invention relates to a microorganism having L-tryptophan productivity and a method for producing L-tryptophan using the same. More precisely, the present invention relates to the recombinant E. coli strain CJ600 (KCCM 10812P) having tryptophan productivity produced from the mutant form (KFCC 10066) of E. coli having L-phenylalanine productivity, wherein tryptophan auxotrophy is released, L-phenylalanine biosynthesis is blocked but tryptophan productivity is enhanced by reinforcing the gene involved in tryptophan biosynthesis, and a method of producing L-tryptophan using the same. |
| US08945906B2 |
Organic biofilm substrata as a microbial inoculum delivery vehicle for bioaugmentation of persistent organic pollutants in contaminated sediments and soils
A system and methods for removal of persistent organic pollutants (POPs) from an environment, where the system includes an inert and organic biofilm substrata as biofilm media for dual use: 1) inoculation of microorganisms to degrade POPs and 2) accumulation of POPs on the substrata, effective in maintaining bioavailable concentrations for sustaining microbial activity. Microorganisms capable of degrading or transforming POPs are actively associated with the substrata as a biofilm. Application of this delivery vehicle will enhance the microbial degradation of POPs, while simultaneously adsorbing hydrophobic POPs from the environment making them bioavailable for the microorganisms located in the formed biofilms and additionally lowering the aqueous concentration of POPs that have detrimental effects towards fish and mammals as they bioaccumulate through the food chain. |
| US08945902B2 |
Combinatorial discovery of enzymes with utility in biomass transformation
Methods for the cell-free identification of polypeptide and polypeptide combinations with utility in biomass transformation, as well as specific novel polypeptides and cell-free systems containing polypeptide combinations discovered by such methods are disclosed. |
| US08945897B2 |
Materials and methods for conjugating a water soluble fatty acid derivative to a protein
The invention relates to materials and methods of conjugating a water soluble fatty acid derivative to a therapeutic protein comprising contacting the therapeutic protein with an activated water soluble fatty acid derivative under conditions that allow conjugation. |
| US08945889B2 |
Method of using alpha-amylase from Aspergillus clavatus for saccharification
A fungal α-amylase is provided from Aspergillus clavatus (AcAmyl). AcAmyl has an optimal pH of 4.5 and is operable at 30-75° C., allowing the enzyme to be used in combination with a glucoamylase in a saccharification reaction. This obviates the necessity of running a saccharification reaction as a batch process, where the pH and temperature must be readjusted for optimal use of the α-amylase or glucoamylase. AcAmyl also catalyzes the saccharification of starch substrates to an oligosaccharide composition significantly enriched in DP2 and (DP1+DP2) compared to the products of saccharification catalyzed by an α-amylase from Aspergillus kawachii. This facilitates the utilization of the oligosaccharide composition by a fermenting organism in a simultaneous saccharification and fermentation process, for example. |
| US08945887B2 |
Whole cell biocatalyst
The present invention relates to a method for producing a product of a reaction catalysed by a nitrilase, which method comprises the steps (i) providing a microorganism comprising said nitrilase located on its surface, and/or a membrane preparation of said microorganism, and (ii) contacting the microorganism and/or the membrane preparation thereof with one or more nitrilase substrates under conditions compatible with nitrilase activity. The present invention further relates to a method for producing enantiomerically pure (R)-mandelic acid using the nitrilase-displaying whole cell biocatalyst or membrane preparation thereof for the conversion of racemic mandelonitrile. |
| US08945886B2 |
Methods for producing polyunsaturated fatty acid and lipid containing polyunsaturated fatty acid
A method for producing a polyunsaturated fatty acid (PUFA) or a lipid containing a PUFA, a microbial cell containing a PUFA, and use of the microbial cell are provided. A method for producing a polyunsaturated fatty acid (PUFA) or a lipid containing a PUFA including culture of a microorganism capable of producing arachidonic acid (ARA) and/or dihomo-gamma-linolenic acid (DGLA) is provided, the method including at least one of the following steps: (a) adding an organic acid in an amount of 0.01 to 5 w/v % to a culture medium after the beginning of main culture; (b) increasing the pH of the culture medium to a range effective for culture after the beginning of the main culture; and (c) adding a metal sulfate in an amount of 0.01 to 0.5 w/w % to the main culture medium. |
| US08945885B2 |
Minicircle DNA vector preparations and methods of making and using the same
The present invention provides minicircle nucleic acid vector formulations for use in administering to a subject, wherein the minicircle nucleic acid vectors include a polynucleotide of interest, a product hybrid sequence of a unidirectional site-specific recombinase, and are devoid of plasmid backbone bacterial DNA sequences. Also provided are methods of producing the subject formulations as well as methods for administering the minicircle nucleic acid vector formulations to a subject. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications. |
| US08945883B2 |
In situ cloning from pathological tissue specimens
The present invention pertains to methods related to cloning nucleic acids from biological samples, particularly pathological tissue samples. This method includes hybridizing a population of oligonucleotide sequence probes comprising degenerate sequence tags to a fixed tissue, isolating the hybridized oligonucleotide sequence probes and amplifying the sequence tags in the hybridized oligonucleotide sequence probes. This method can be utilized to identify genes associated with disease and to quantitate the expression of disease-related transcripts. The method can also be used to identify truncated mRNAs. |
| US08945882B2 |
DNA polymerases with improved activity
Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases. |
| US08945881B2 |
Localized temperature control for spatial arrays of reaction media
Individual temperature control in multiple reactions performed simultaneously in a spatial array such as a multi-well plate is achieved by thermoelectric modules with individual control, with each module supplying heat to or drawing heat from a single region within the array, the region containing either a single reaction vessel or a group of reaction vessels. |
| US08945879B2 |
Methods for recombinant expression of a polypeptide comprising a carbohydrate binding module using a host cell having reduced expression of a protease
The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. |
| US08945878B2 |
Methods for identifying and isolating cells expressing a polypeptide
The invention relates to novel polypeptides and cells comprising the polypeptides. The polypeptides and cells are used in methods to identify and/or isolate cells producing a protein with specific biological functions. In particular, the methods may be used for identifying, selecting, and isolating cells producing antigen-specific monoclonal antibodies. |
| US08945876B2 |
Auto-processing domains for polypeptide expression
Embodiments herein include methods and constructs that can be used to co-express two or more polypeptides of interest from a single polynucleotide encoding a precursor polypeptide. Within this precursor polypeptide can reside at least one autonomous processing unit, which can mediate release of flanking polypeptides of interest in cis. The processing unit can include an N-terminal autocatalytic cleavage domain and a C-terminal cleavage domain. Some embodiments include constructs and methods for co-expressing polypeptides without N- or C-terminal overhangs, in any cellular or extracellular location, and/or in stoichiometric ratios. |
| US08945875B2 |
Product and process for transformation of thraustochytriales microorganisms
Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, α-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as a method of transformation of Thraustochytriales microorganisms. The recombinant nucleic acid molecules of the present invention can be used for the expression of foreign nucleic acids in a Thraustochytriales microorganism as well as for the deletion, mutation, or inactivation of genes in Thraustochytriales microorganisms. |
| US08945872B2 |
Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein
Expression vector systems are provided for increased production of a recombinant GDF-5 (rhGDF-5) protein. Also provided are transformed host cells that were engineered to produce and express high levels of rhGDF-5 protein. Methods for production and high expression of rhGDF-5 protein are disclosed herein. The methods of enhancing production and protein expression of rhGDF-5 protein as disclosed are cost-effective, time-saving and are of manufacturing quality. |
| US08945870B2 |
DNA encoding an anti-system ASC amino acid transporter 2 (ASCT2) antibody
An object of the present invention is to provide a monoclonal antibody which is useful for treating or diagnosing a disease relating to system ASC amino acid transporter 2 (hereinafter, referred to as “ASCT2”) or a method using the antibody. The present invention provides a monoclonal antibody which specifically recognizes a native three-dimensional structure of an extracellular region of ASCT2 and binds to the extracellular region, or an antibody fragment thereof; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof, and a diagnostic agent using the antibody or the antibody fragment thereof. |
| US08945867B2 |
Process for producing polypeptide
The present invention relates to a process for producing a desired polypeptide using rat cells. Specifically, the present invention relates to a process for producing the polypeptide which comprises culturing rat cells such as YB2/3HL.P2.G11.16Ag.20 (hereinafter referred to as YB2/0), preferably rat cells to which a recombinant DNA comprising DNA encoding a desired polypeptide such as an immunologically functional molecule is introduced, in a medium which does not contain serum (hereinafter referred to as a serum-free medium). Among the desired polypeptides obtained by the process of the present invention, an antibody obtained by using a transformant of YB2/0 has a high antibody-dependent cell-mediated cytotoxic activity (hereinafter sometimes referred to as ADCC activity) and is useful as a pharmaceutical agent. |
| US08945866B2 |
Method and apparatus for cutting and collecting dissected specimens
Methods and devices for cutting and collecting dissected specimens are described herein. In one embodiment, the method for dissecting and collecting specimens includes the following steps: placing a sample onto a slide of a laser dissection microscope, the slide being translatable in its plane of extension, lowering an adherent collection device centered on the optical axis onto the probe, wherein the adherent collection device, in its lowered state, adheres to the sample, is freely translatable with the slide and decoupled from the optical axis of the microscope, and, in its raised state, is fixed relative to the optical axis, dissecting one or more specimens from the sample, wherein the following steps are performed if the next specimen to be dissected is located outside of a predetermined collection radius of the adherent collection device: raising the adherent collection device, translating the slide to a given position relative to the optical axis of the microscope in order to decenter the center of the specimen to be dissected from the optical axis of the microscope, lowering the adherent collection device onto the sample, and dissecting one or more subsequent specimens, wherein, after each step of raising the adherent collection device, the predetermined position is spaced apart from all previously determined positions by at least one predetermined distance. |
| US08945863B2 |
Method for measuring the activity of cathepsin B after de-inhibition
The present invention relates to a method for measuring the activity of enzymes in a sample which contains at least one enzyme and at least one enzyme inhibitor corresponding to said enzyme, whereby after de-inhibition the activity of the released enzyme is measured in such a way that a substrate is added to the sample and the time course of the concentration of at least one reaction product (cleavage product) is recorded and the enzyme specific substrate has a fluorogenic part which is cleaved in the enzymatic reaction and the fluorescence (measuring parameter) of which can be detected in a wavelength range where the measuring parameter can be assigned unambiguously to the enzyme activity to be measured, whereby the de-inhibition is carried out by immersing a rigid carrier, to which the inhibitor binding substance is bound, into the sample. The present invention relates also to a corresponding device for measuring the activity on enzymes in a sample. |
| US08945862B2 |
Triple-fusion constructs and methods of monitoring human embryonic stem cells
Embodiments of the present disclosure include triple-fusion human embryonic stem cells, methods of imaging triple-fusion human embryonic stem cells, triple-fusion polynucleotides, triple-fusion proteins, methods of monitoring the progression of human embryonic stem cells, methods of making isolated triple-fusion human embryonic stem cells, and the like. |
| US08945860B2 |
Highly sensitive monoclonal antibody residual detection assay
The present invention relates to compositions and highly sensitive methods for the detection of biotechnology product residual when monitoring product carry over and/or for cleaning verification in the manufacture of biotechnology products. In particular, the present invention is directed to immunoassays wherein one or more capture antibodies, or antigen binding fragments thereof, are used to detect residuals associated with the production of biotechnology products. |
| US08945856B2 |
Affinity-based detection of biological targets
A method of biochemical identification by: providing a plurality of capture species bound to one or more substrates and suspected of having one or more biological targets affinity bound to at least one capture species; detecting which capture species contain bound biological targets to generate a binding pattern; and identifying the biological target based on the binding pattern. The capture species are independently selected from the group consisting of antimicrobial peptides, cytotoxic peptides, antibiotics, and combinations thereof. A device having the capture species bound to the substrates. At least two of the capture species are capable of multi-specific binding to one or more biological targets and may have overlapping but not identical affinity properties. |
| US08945854B2 |
Methods and compositions for biomarkers of fatigue
The present invention provides methods and compositions for identifying fatigue, disease states associated with fatigue, recovery from fatigue and/or physical performance capability in a subject. |
| US08945844B2 |
Method of amplifying target nucleic acid with reduced amplification bias and method for determining relative amount of target nucleic acid in sample
A method of amplifying a target nucleic acid with reduced amplification bias and a method of determining a relative amount of a target nucleic acid in a sample. |
| US08945839B2 |
CRISPR-Cas systems and methods for altering expression of gene products
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. |
| US08945835B2 |
Method for sequencing a polynucleotide template
The invention provides methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. |
| US08945833B2 |
Method for determining drug resistance mutations in any of the non-structural protein regions NS3 to NS5B of hepatitis C virus (HCV) for genotypes 1 to 6
The present invention relates to a method for determining drug resistance mutations in any of the non-structural protein regions NS3 to NS5B of Hepatitis C Virus (HCV) for genotypes 1 to 6, more in particular for subtype specific genotypes 1a, 1b, 2a, 2b, 3a, 4a and 4d. |
| US08945829B2 |
Distinguishing benign and malignant indeterminate thyroid lesions
The application describes methods for accurately evaluating whether thyroid test samples, especially indeterminate thyroid samples, are benign or malignant. |
| US08945826B2 |
Heat-stable carbonic anhydrases and their use
The present invention relates to use of Caminibacter carbonic anhydrase in CO2 extraction, e.g., from flue gas, natural gas, biogas or ambient air. The Caminibacter carbonic anhydrases are especially well suited for these purpose due to their extreme thermostability. |
| US08945822B2 |
Resist pattern thickening material, method for forming resist pattern, semiconductor device and method for manufacturing the same
The present invention provides a resist pattern thickening material, which can utilize ArF excimer laser light; which, when applied over a resist pattern to be thickened, e.g., in form of lines and spaces pattern, can thicken the resist pattern to be thickened regardless of the size of the resist pattern to be thickened; and which is suited for forming a fine space pattern or the like, exceeding exposure limits. The present invention also provides a process for forming a resist pattern and a process for manufacturing a semiconductor device, wherein the resist pattern thickening material of the present invention is suitably utilized. |
| US08945818B2 |
Method of manufacturing liquid ejection head
A method of manufacturing a liquid ejection head, and the method includes a process of providing a first photosensitive resin layer containing a photodegradable positive photosensitive resin and serving as a mold material of the channel on a substrate, a process of providing a gas barrier layer having a film density of 1 g/cm3 or more on the first photosensitive resin layer, a process of subjecting the first photosensitive resin layer and the gas barrier layer to pattern exposure, and then performing development to thereby form the mold material of a channel and also removing the gas barrier layer before or simultaneously with the development, a process of providing a second photosensitive resin layer on the mold material and the substrate, a process of subjecting the second photosensitive resin layer to pattern exposure, and then performing development, and a process of removing the mold material of the channel. |
| US08945816B2 |
Method for forming resist pattern, semiconductor device and production method thereof
A method for producing a semiconductor device includes forming a resist pattern by coating a resist pattern thickening material to cover the surface of the resist pattern, baking the resist pattern thickening material, and developing and separating the resist pattern thickening material, wherein at least one of the coating, the baking and the developing is carried out plural times. |
| US08945810B2 |
Positive resist composition and pattern-forming method
A positive resist composition comprises: (A) a resin that has a repeating unit represented by general formula (a1) and increases its solubility in an alkali developer by action of an acid; (B) a compound which generates an acid upon irradiation with an actinic ray or a radiation; and (C) a resin that has at least one of a fluorine atom and a silicon atom and has a group selected from the group consisting of (x), (y) and (z); and (D) a solvent: (x) an alkali-soluble group; (y) a group capable that decomposes by action of an alkali developer to undergo an increase in a solubility of the resin (C) in an alkali developer; and (z) a group that decomposes by action of an acid, wherein R represents a hydrogen atom or a methyl group, Rxa represents an alkyl group or a cycloalkyl group, and n represents an integer of 1 to 8. |
| US08945809B2 |
Fluorinated monomer, fluorinated polymer, resist composition, and patterning process
A fluorinated monomer has formula (1) wherein R1 is H, F, methyl or trifluoromethyl, R2 is a monovalent hydrocarbon group which may have halogen or oxygen, A is a divalent hydrocarbon group, and k1 is 0, 1 or 2. A polymer derived from the fluorinated monomer may be endowed with appropriate water repellency, water slip, acid lability and hydrolysis and is useful as an additive polymer in formulating a resist composition. |
| US08945808B2 |
Self-topcoating resist for photolithography
Resist compositions that can be used in immersion lithography without the use of an additional topcoat are disclosed. The resist compositions comprise a photoresist polymer, at least one photoacid generator, a solvent; and a self-topcoating resist additive. A method of forming a patterned material layer on a substrate using the resist composition is also disclosed. |
| US08945806B2 |
Electrostatic charge image developing toner, electrostatic charge image developer, toner cartridge, developer cartridge, process cartridge, image forming apparatus, and image forming method
An electrostatic charge image developing toner includes toner particles that contain a colorant, a binder resin and a release agent, and an external additive, in which the external additive contains inorganic particles including an aliphatic alcohol having 5 or more carbon atoms and a melting point of 20° C. or lower on the surfaces thereof. |
| US08945804B2 |
Treated metal oxide particles and toner compositions
Treated metal oxide particles include metal oxide particles treated with at least a charge modifying agent. The charge modifying agent is represented by the following formula: An-Zc—Yb—Ar(EW)a wherein Ar represents an aromatic group, EW represents an electron withdrawing group, Y represents a spacer group, Z represents an alkylene group, An represents an anchor group, a is an integer from 1 to 5, b is 0 or 1, and c is 0 or 1. The treated metal oxide particles may also be treated with a second charge modifying agent or with a hydrophobicity-imparting agent. A toner composition including toner particles and treated metal oxide particles is also disclosed. |
| US08945803B2 |
Smart subfield method for E-beam lithography
The present disclosure provides a method of improving a layer to layer overlay error by an electron beam lithography system. The method includes generating a smart boundary of two subfields at the first pattern layer and obeying the smart boundary at all consecutive pattern layers. The same subfield is exposed by the same electron beam writer at all pattern layers. The overlay error caused by the different electron beam at different layer is improved. |
| US08945798B2 |
Near-field exposure mask and pattern forming method
A near-field exposure mask according to an embodiment includes: a substrate; a concave-convex structure having convexities and concavities and formed on one surface of the substrate; a near-field light generating film arranged at least on a tip portion of each of the convexities, the near-field light generating film being a layer containing at least one element selected from the group consisting of Au, Al, Ag, Cu, Cr, Sb, W, Ni, In, Ge, Sn, Pb, Zn, Pd, and C, or a film stack formed with layers made of some of those materials; and a resin filled in each of the concavities. |
| US08945796B2 |
Cell for fuel cell, method for producing the same, and gas channel structure for fuel cell
A cell for a fuel cell, comprising a membrane electrode assembly, expanded moldings that are laminated to both surfaces of the membrane electrode assembly and form gas channels, and separators that are laminated to the gas channel structures and separate the gases between adjacent cells, wherein each of the expanded moldings comprises a gas channel substrate formed from a metal material such as a titanium material or a stainless steel, a conductive layer that is formed from a conductor such as gold on a contact portion of the gas channel substrate that contacts the membrane electrode assembly or the separator, and a hydrophilic layer that is formed from a hydrophilic material such as a titanium oxide on the gas channel surface of the gas channel substrate. |
| US08945794B2 |
Process for forming silver films on silicon
A process is provided for etching a silicon-containing substrate. In the process, the surface of the substrate is cleaned. A film of alumina is deposited on the cleaned substrate surface. A silver film is deposited above the film of alumina. An etchant comprising HF is contacted with the silver film. |
| US08945792B2 |
Separator for fuel cell
A separator for a fuel cell includes a metal plate which defines a passage and a manifold, frames having gaskets which are integrated therewith using injection, and a bonding unit for bonding the frames to the metal plate. The gaskets may be differently formed. This resolves process interference problems between conductive surface treatment and gasket cross-linking, obviates deburring of the gasket, and preventes poor injection of the gaskets, which ensures stable quality of the separator, increases productivity and decreases the manufacturing cost. |
| US08945790B2 |
Microporous layer structures and gas diffusion layer assemblies in proton exchange membrane fuel cells
In at least one embodiment, a microporous layer configured to be disposed between a catalyst layer and a gas diffusion layer of a fuel cell electrode assembly is provided. The microporous layer may have defined therein a plurality of hydrophilic pores, a plurality of hydrophobic pores with a diameter of 0.02 to 0.5 μm, and a plurality of bores with a diameter of 0.5 to 100 μm. The microporous layer structures and gas diffusion layer assemblies disclosed herein may be defined by a number of various designs and arrangements for use in proton exchange membrane fuel cell systems. |
| US08945789B2 |
Solid oxide fuel cell
The present invention provides a solid oxide fuel cell (SOFC) including a porous fuel electrode which allows reaction of a fuel gas to proceed and which is formed of Ni and YSZ, a porous air electrode which allows reaction of an oxygen-containing gas to proceed, and a dense solid electrolyte membrane which is provided between the fuel electrode and the air electrode and which has an interface with the fuel electrode. In the fuel electrode, Ni grains present in a region located within 3 μm from the interface (i.e., a “near-interface region”) have a mean size of 0.28 to 0.80 μm, YSZ grains present in the near-interface region have a mean size of 0.28 to 0.80 μm, and pores present in the near-interface region have a mean size of 0.10 to 0.87 μm. Thus, the fuel electrode of the SOFC exhibits low reaction resistance. |
| US08945788B2 |
Fuel cell system
A fuel cell system whose fuel loss caused by the crossover of the fuel is small and which can be operated economically. The fuel cell system includes a fuel cell 10, a primary feeding system 12 for feeding a primary fuel which is a liquid fuel to the fuel cell 10, a secondary feeding system 13 for feeding a secondary fuel which is a liquid fuel whose saturation vapor pressure is lower than that of the primary fuel to the fuel cell 10, a ECU 30 for controlling each part so that the primary fuel in the fuel cell is replaced with the secondary fuel when terminating the operation of the fuel cell 10. |
| US08945784B2 |
Hydrogen production apparatus and fuel cell system using the same
There are provided a hydrogen production apparatus and a hydrogen producing method that can easily bring the temperature of a gas to be supplied to a preferential oxidation catalyst bed to a proper range without the necessity of flow rate control of a cooling medium, and a fuel cell system which is relatively inexpensive and can easily realize stable operation. The hydrogen producing method includes a reforming step of obtaining a hydrogen-containing gas from a raw material for hydrogen production by utilizing a reforming reaction, a shift reaction step of reducing the concentration of carbon monoxide in the gas obtained from the reforming step by a shift reaction, a cooling step of cooling the gas obtained from the shift reaction step, a heating step of heating the gas cooled in the cooling step and a preferential oxidation reaction step of reducing the concentration of carbon monoxide in the gas heated in the heating step, wherein in the heating step, the gas cooled in the cooling step is heated by heat exchange with the use of heat generated by the preferential oxidation reaction. A hydrogen production apparatus suitable for implementing this method. A fuel cell system provided with the hydrogen production apparatus. |
| US08945782B2 |
Method of producing a multilayer barrier structure for a solid oxide fuel cell
The present invention provides a method of producing a multilayer barrier structure in a solid oxide cell stack, comprising the steps of: —providing a metal interconnect; —applying a first metal oxide layer on said metal interconnect; —applying a second metal oxide layer on top of said first metal oxide layer; —applying a third metal oxide layer on top of said second metal oxide layer; —forming a solid oxide cell stack comprising said metal interconnect having said metal oxide layers thereon; and —reacting the metal oxide in said first metal oxide layer with the metal of said metal interconnect during the SOC-stack initialization, and a solid oxide stack comprising an anode contact layer and support structure, an anode layer, an electrolyte layer, a cathode layer, a cathode contact layer, a metallic interconnect, and a multilayer barrier structure which is obtainable by the above method and through an initialization step, which is carried out under controlled conditions for atmosphere composition and current load, which depends on the layer composition facilitating the formation of the desired reaction products as a dense barrier layer without chromium species migrating to the air-electrode. |
| US08945778B2 |
Conducting salts for galvanic cells, the production thereof and their use
The invention relates to conducting salts which contain lithium bis(oxalato)borate (LiBOB) and mixed lithium borate salts of the type of formula (I), wherein the portion of compound (I) in the conducting salt is 0.01 to 20 mole-% and X in formula (I) is a bridge linked with the boron via two oxygen atoms, selected from formula (II), wherein Y1 and Y2 together=O, m=1, n=0 and Y3 and Y4 independently represent H or an alkyl group with 1 to 5 C atoms, or Y1, Y2, Y3, Y4 independently represent OR (with R=alkyl group with to 5 C atoms), or H or an alkyl group with 1 to 5 C atoms, and wherein m=0 or 1, n=0 or 1, or Y2 and Y3 are members of a 5- or 6-membered aromatic or heteroaromatic ring (with N, O or S as the hetero element) which can be optionally substituted with alkyl, alkoxy, carboxy or nitrile, and if so, Y1 and Y4 are not applicable and n>0, m=0 or 1. The invention also relates to a method for producing the inventive conducting salts. |
| US08945776B2 |
Electrolyte for rechargeable lithium battery and rechargeable lithium battery including the same
An electrolyte for a rechargeable lithium battery and a rechargeable lithium battery including the same, the electrolyte including a lithium salt, a silylborate-based compound, an anhydride component, and a non-aqueous organic solvent. |
| US08945775B2 |
Battery having a porous insulating member
A main object of the present application is to provide a battery including an insulating member that insulates a battery case from an electrode body and is able to secure good injection performance of an electrolyte solution. The battery provided by the present application includes an electrode body provided with a positive electrode and a negative electrode, and a battery case that houses the electrode body together with an electrolyte solution. An insulating member that isolates the electrode body from the battery case is arranged between the electrode body and the battery case, and the insulating member is formed into a bag shape that encloses the electrode body and is made of a porous material having pores through which the electrolyte solution is able to flow. |
| US08945774B2 |
Additive for lithium ion rechageable battery cells
The present invention claims the addition of vinylene carbonate (VC) and optionally also fluoroethylene carbonate to the electrolyte of lithium ion cells having a structural silicon composite anode, i.e. an anode containing fibers or particles of silicon. The additive significantly improves the cycling performance of the cells. A VC content in the range 3.5-8 wt % based on the weight of the electrolyte has been found to be optimum. |
| US08945773B2 |
Negative electrode active material for nonaqueous electrolyte battery, method of producing the same, nonaqueous electrolyte battery and battery pack
According to one embodiment, a negative electrode active material for nonaqueous electrolyte battery includes a titanium oxide compound having a crystal structure of monoclinic titanium dioxide. When a monoclinic titanium dioxide is used as the active material, the effective capacity is significantly lower than the theoretical capacity though the theoretical capacity was about 330 mAh/g. The invention comprises a titanium oxide compound which has a crystal structure of monoclinic titanium dioxide and a (001) plane spacing of 6.22 Å or more in the powder X-ray diffraction method using a Cu—Kα radiation source, thereby making an attempt to improve effective capacity. |
| US08945768B2 |
Lithium-ion secondary battery
A lithium-ion secondary battery 100 includes a positive electrode current collector 221 and a porous positive electrode active material layer 223 retained by the positive electrode current collector 221. The positive electrode active material layer 223 contains, for example, positive electrode active material particles 610, an electrically conductive material 620, and a binder 630. In this lithium-ion secondary battery 100, the positive electrode active material particles 610 have a shell portion 612 constituted by a lithium transition metal oxide, a hollow portion 614 formed inside the shell portion 612, and a through hole 616 penetrating the shell portion 612. In the lithium-ion secondary battery 100, in the positive electrode active material layer 223 on average, the hollow portion 614 accounts for 23% or higher of an apparent sectional area of the positive electrode active material particles 610. In addition, a thickness of the shell portion 612 in the positive electrode active material layer 223 on average is 2.2 μm or less. |
| US08945767B2 |
Aqueous coating liquid for an electrode plate, electrode plate for an electrical storage device, method for manufacturing an electrode plate for an electrical storage device, and electrical storage device
A water-based coating formulation for an electrode plate of an electricity storage device, said water-based coating formulation being adapted to form a coating film layer on the electrode plate, contains at least one resin binder having a saponification degree of 40% or higher and selected from unmodified and modified polyvinyl alcohols and unmodified and modified ethylene-vinyl alcohol copolymers, an electrically conductive material, and a specific polybasic acid or its acid anhydride in a water-based medium containing water as a polar solvent. Per parts by mass of the electrically conductive material (2), the resin binder is from 0.1 to 3 parts by mass and the polybasic acid or the like is from 0.01 to 6 parts by mass. The coating formulation has a solids content from 0.02 mass % to 40 mass %. |
| US08945765B2 |
Secondary lithium battery electrolyte and secondary lithium battery including the same
A secondary lithium battery electrolyte including a lithium salt, a nonaqueous organic solvent, and an electrolyte additive represented by Formula 1: where n is an integer in the range of 1 to 4. A secondary lithium battery having excellent cycle and high temperature retention characteristics can be provided by using such secondary lithium battery electrolyte. |
| US08945764B2 |
Battery pack of large capacity
Disclosed herein is a battery pack including a battery cell, having an electrode assembly mounted in a pouch-shaped battery case made of a laminate sheet including a metal layer and a resin layer and is sealed by thermal welding, mounted in a pack case, wherein the pack case includes a frame member constructed in a structure in which a receiving part for receiving the battery cell is open, opposite side sealing portions of the battery cell are mounted to the frame member such that the opposite side sealing portions cover the opposite sides of the frame member, and a sheathing film is applied to the outer surface of the frame member, to which the battery cell is mounted. |
| US08945760B2 |
Storage element and terminal fabricating method
A storage element includes: an external terminal having an exposed surface which is exposed to the outside from an envelope, a current collector which is contained inside of the envelope and is connected to the external terminal, and a power generating element which is contained inside of the envelope and is connected to the current collector. The external terminal includes: a flat portion exposed to the outside; and a shaft projecting from the flat portion to the inside of the envelope and being connected to the current collector. |
| US08945757B2 |
Battery pack having conductive line holders
A battery pack including: a plurality of battery cells; conductive tabs, each of which has a first portion electrically connected to at least one of the battery cells, and a second portion extending from the first portion; conductive lines electrically connected to the second portions of the conductive tabs; and a protective circuit module electrically connected to the conductive lines. Each of the conductive tabs includes a conductive line holding portion formed at the second portion, to fix the corresponding conductive line. Due to this constitution of the battery pack, the conductive lines are prevented from entirely escaping from the area of solder joints with the conductive tabs, after being disconnected from the solder joints. Therefore, the conductive lines do not come into contact with the battery cells or circuits of the protective circuit module. |
| US08945753B2 |
Implantable battery having thermal shutdown separator
The present teachings include an electrochemical cell including an anode, a cathode, an electrolyte, a separator disposed between the cathode and anode, and a housing containing the anode, cathode, electrolyte, and separator. The separator can include a first sheet consisting essentially of a single layer material and a second sheet distinct from the first sheet. The second sheet can include an inner microporous layer laminated between two more outer layers. In some cells, the inner layer can have a transition temperature between a porous configuration and a substantially non-porous configuration that is between about 80 degrees C. and 150 degrees C., and in which the two more outer layers maintain their structural integrity to at least about 10 degrees C. greater than the first layer transition temperature. |
| US08945750B2 |
Electronic apparatus, control method and program thereof, and battery for operating electronic apparatus
An electronic apparatus using a fuel cell as at least one electric power source. The fuel cell has an electric power output unit for outputting an electric power through a chemical reaction between fuel gas and oxidant gas, a purge device for purging the electric power output unit and a purge control unit for issuing a purge instruction to the purge device. The electronic apparatus has a monitor unit for monitoring a consumption power, an operation state or a manipulated state of the electronic apparatus, and a purge permission unit for judging from an output of the monitor unit whether the purge control unit is permitted to issue the purge instruction, and outputting a judgment result to the purge control unit. |
| US08945746B2 |
Battery pack with improved heat dissipation efficiency
Provided is a battery pack with improved heat dissipation efficiency. The battery pack includes a holder case, and a plurality of batteries disposed inside the holder case. The holder case includes a plurality of ribs disposed inside the holder case. Each of the ribs has a column extending in a direction substantially parallel to a side surface of the holder case, and each of the batteries is accommodated between the columns of the ribs. The column has a heat dissipation hole therein extending along the extension direction of the column. An air flow is formed through the heat dissipation hole, and heat generated during a charge and/or discharge operation dissipates through the air flow in the heat dissipation hole. A portion of the columns are separated from each other forming a gap. The heat generated from the batteries also dissipates through this gap. |
| US08945743B2 |
Stepped electrode assembly having predetermined a thickness ratio in the interface between electrode units, battery cell and device comprising the same
There are provided an electrode assembly, and a battery cell, a battery pack, and a device. The electrode assembly includes a combination of two or more types of electrode units having different areas, wherein the electrode units are stacked such that steps are formed, and electrode units are formed such that a positive electrode and a negative electrode face one another at an interface between the electrode units. |
| US08945740B2 |
Vent for electrochemical cell
An electrochemical cell includes a housing having a first end and a vent located at the first end that is configured to deploy from the housing to allow the expulsion of gases from within the cell. The electrochemical cell also includes at least one projection extending outward from the first end adjacent the vent. The at least one projection is configured to prevent accidental deployment of the vent. |
| US08945734B2 |
Secondary battery including protection circuit module
An easily assembled pack type secondary battery. The secondary battery includes a bare cell, a protection circuit module having a circuit board and coupled with the bare cell, and a top case covering the circuit board of the protection circuit module and having a coupling slot into which at least part of the circuit board is fitted. The secondary battery allows the top case to be attached to the protective circuit module and the bare cell without having to use an adhesive and without requiring an injection molding technique. |
| US08945731B2 |
Interlayer for device including NFT and cladding layers
A device that includes a near field transducer (NFT); at least one cladding layer adjacent the NFT; and a discontinuous metal layer positioned between the NFT and the at least one cladding layer. |
| US08945727B2 |
Organoselenium materials and their uses in organic light emitting devices
The present invention provides organoselenium compounds comprising dibenzoselenophene, benzo[b]selenophene or benzo[c]selenophene and their uses in organic light emitting devices. |
| US08945726B2 |
Polymer for organic electroluminescent element, and organic electroluminescent element using the same
Provided are a polymer for an organic electroluminescent element, which improves light emission efficiency of the element and is applicable to a wet process, and an organic electroluminescent element, which is obtained using the polymer. The polymer for an organic electroluminescent element includes a repeating unit represented by the following general formula (1) in a repeating unit constituting a main chain. Further, the organic electroluminescent element includes organic layers between an anode and a cathode laminated on a substrate, in which at least one of the organic layers includes the polymer for an organic electroluminescent element, including an indolocarbazole skeleton in the repeating unit constituting a main chain. In the general formula (1), Z represents an N-indolocarbazolyl group, W represents a charge transporting group, m and n represent molar ratios, m represents 0 to 95 mol %, and n represents 5 to 100 mol. |
| US08945722B2 |
Materials and architectures for efficient harvesting of singlet and triplet excitons for white light emitting OLEDs
The present invention relates to organic light emitting devices (OLEDs), and more specifically to OLEDS that emit light using a combination of fluorescent emitters and phosphorescent emitters for the efficient utilization of all of the electrically generated excitons. |
| US08945719B2 |
Steel plate for cold forging and process for producing same
This steel plate for cold forging includes a hot-rolled steel plate, wherein the hot-rolled steel plate includes: in terms of percent by mass, C: 0.13% to 0.20%; Si: 0.01% to 0.8%; Mn: 0.1% to 2.5%; P: 0.003% to 0.030%; S: 0.0001% to 0.008%; Al: 0.01% to 0.07%; N: 0.0001% to 0.02%; and O: 0.0001% to 0.0030%, with a remainder being Fe and inevitable impurities, an A value represented by the following formula (1) is in a range of 0.0080 or less, a thickness of the hot-rolled steel plate is in a range of 2 mm to 25 mm, and an area percentage of pearlite bands having lengths of 1 mm or more in a region of 4/10t to 6/10t when a plate thickness is indicated by t in a cross section of a plate thickness that is parallel to a rolling direction of the hot-rolled steel plate is in a range of not more than a K value represented by the following formula (2), A value=O%+S%+0.033Al% (1) K value=25.5×C%+4.5×Mn%−6 (2). |
| US08945717B2 |
Adhesive material
The invention relates to a pressure-sensitive adhesive. It is envisaged that the pressure-sensitive adhesive comprises a first layer and a second layer,the first layer being a heat-activatable pressure-sensitive adhesive which has a static glass transition temperature Tg,a or a melting point Tm,a of at least +30° C.; andthe second layer being a polyacrylate pressure-sensitive adhesive which has a static glass transition temperature of not more than +15° C. |
| US08945715B2 |
Low V2O5—content and V2O5—free porcelain enamels
The present invention relates to a low-V2O5-content and even V2O5-free porcelain enamel with improved dish-washer resistance, very good acid resistance and good adherence on various substrates. The invention moreover relates to a transparent low-V2O5-content and even V2O5-free porcelain enamel frit for application of enamel coatings with infinite color range on a substrate made of aluminum, cast aluminum, aluminum alloy, aluminum-magnesium alloy, cast aluminum alloy, copper, austenitic stainless steel and mild steel, presenting improved dish-washer resistance, good acid resistance and good adherence on the substrate.The composition of the porcelain enamel in question comprises about 30 wt-% to about 50 wt-% SiO2, about 30 wt-% to about 40 wt-% R2O, about 15 wt-% to about 25 wt-% TiO2, about 0 wt-% to about 5 wt-% RO, about 0 wt-% to about 4 wt-% V2O5, about 0.3 wt-% to about 7 wt-% Fe2O3, about 0 wt-% to about 3 wt-% Sb2O3, about 0 wt-% to about 3 wt-% SnO2, about 0 wt-% to about 2 wt-% B2O3, about 0 wt-% to about 3 wt-% Al2O3, about 0 wt-% to about 4 wt-% P2O5, about 0 wt-% to about 1 wt-% MoO3, about 0 wt-% to about 2 wt-% F2, about 0 wt-% to about 4 wt-% ZrO2, about 0 wt-% to about 4 wt-% ZnO, about 0 wt-% to about 6 wt-% NOx, R2O is a combination of alkaline oxides selected from the group of: Na2O 10-23 mol %, K2O 7-20 mol % and Li2O 1-6.5 mol %, wherein RO represent at least one earth alkali oxide and wherein the molar ratio of (Li2O+B2O3) to TiO2 amounts to 0.2 to 0.6. |
| US08945714B2 |
Coated article with IR reflecting layer and method of making same
Example embodiments of this invention relate to a coated article including an infrared (IR) reflecting layer of a material such as silver or the like, for use in an insulating glass (IG) window unit for example. In certain example embodiments, the coating is a single-silver type coating, and includes an overcoat including an uppermost layer of or including silicon nitride and a layer of or including tin oxide immediately under and contacting the silicon nitride based overcoat. In certain example embodiments, the thicknesses of the silicon nitride based overcoat and the tin oxide based layer are balanced (e.g., substantially equal, or equal plus/minus about 10%). It has surprisingly been found that such balancing results in an improvement in thermal cycling performance and improved mechanical durability. In certain example embodiments, the coating may realize surprisingly good substantially neutral film side reflective coloration, and may achieve an improved visible transmission, SHGC ratio and low U-values. Moreover, in certain example embodiments, stress in the overcoat of the coating may be reduced by reducing nitrogen gas flow (N2 ml/kW) and cathode power during a sputter-deposition process, thereby further improving thermal cycling performance. |
| US08945713B2 |
Glass material for press molding, method for manufacturing optical glass element employing same, and optical glass element
Disclosed is a glass material for press forming providing an optical element having a sufficient optical performance without surface cracks, cloudiness, scratches, and the like even when the glass material contains an easily reducible component. Also disclosed are an optical element having a sufficient optical performance without surface cracks, cloudiness, scratches, and the like and a method for manufacturing the same. Specifically disclosed are a glass material for press forming and a glass optical element each of which comprises a core portion composed of multiple component optical glass and a composite surface layer covering at least a region serving as an optical functional surface of the core portion. The core portion is composed of optical glass that contains an easily reducible component and does not contain Pb. The composite surface layer includes a first surface layer that covers the core portion and a second surface layer that covers the first surface layer. The first surface layer is composed of a component that does not react with the glass of the core portion at the press forming temperature and does not diffuse in the glass of the core portion. The second surface layer is composed of a component that improves formability during the press forming. Also specifically disclosed is a method for manufacturing the optical element. |
| US08945711B2 |
Water-based composite resin composition and an article comprising the same
It is an object of the present invention to provide a water-based composite resin composition which has an excellent long-term storage stability and which enables formation of a coating film having an excellent water resistance and solvent resistance. The present invention relates to a water-based composite resin composition and a coating agent; the water-based composite resin composition containing composite resin particles (A) and an aqueous medium (B), the composite resin particles (A) containing polyester resin (a1) particles having a sulfonate group and an epoxy resin (a2) of which some or all parts are encapsulated in the polyester resin (a1) particles, wherein a mass ratio [(a1)/(a2)] of the polyester resin (a1) to the epoxy resin (a2) in the composite resin particles (A) is in the range of 95/5 to 30/70. |
| US08945707B2 |
Surface-coated cutting tool
The surface-coated cutting tool of the present invention is characterized in that a region of 10 μm in a surface of the base material from point a′ to point b′ has two to seven cracks with a width of not more than 200 nm, or two to ten pores are present per length of 10 μm in the surface of the base material from point a′ to point b′, where points a′ and b′ are points defined respectively by lines drawn perpendicularly from points a and b to the surface of the base material where point a is a position located away from an edge ridgeline toward a rake face by distance La and point b is a position located away from the edge ridgeline toward a flank face by distance Lb. |
| US08945700B2 |
Polymeric materials in self-assembled arrays and semiconductor structures comprising polymeric materials
Methods for fabricating sublithographic, nanoscale microstructures in line arrays utilizing self-assembling block copolymers, and films and devices formed from these methods are provided. Semiconductor structures may include self-assembled block copolymer materials in the form of lines of half-cylinders of a minority block matrix of a majority block of the block copolymer. The lines of half-cylinders may be within trenches in the semiconductor structures. |
| US08945695B2 |
Polyethylene terephthalate resin synthesized inorganic Ti—Mg catalyst and its applications thereof
PET resins containing a small amount of a blue dye and/or further containing inorganic particles of Fe3O4 or BaSO4 are synthesized in the presence of an inorganic Ti—Mg catalyst employed as a polycondensation catalyst and a phosphorus stabilizer during a polycondensation process, and the resultant PET resins are free of yellowish appearance and reduced regenerated acetaldehyde and cyclic oligomers after processed so that PET bottle preforms if made of the PET resins can facilitate reduction in aging time thereby to improve the product yield of the bottle preforms and to save the stock space for storing the bottle preforms. |
| US08945691B2 |
Nano-material and method of fabrication
A fluffy nano-material and method of manufacture are described. At 2000× magnification the fluffy nanomaterial has the appearance of raw, uncarded wool, with individual fiber lengths ranging from approximately four microns to twenty microns. Powder-based nanocatalysts are dispersed in the fluffy nanomaterial. The production of fluffy nanomaterial typically involves flowing about 125 cc/min of organic vapor at a pressure of about 400 torr over powder-based nano-catalysts for a period of time that may range from approximately thirty minutes to twenty-four hours. |
| US08945690B2 |
Method and apparatus for mass-producing DLC films
A DLC film mass-producing apparatus 10 includes a chamber 12 connected to ground. In the chamber 12, a plurality of plate-shaped substrates 60 are disposed in parallel at regular intervals, without disposing a counter electrode that faces each of the plate-shaped substrates 60. Sputtering cleaning is then conducted by plasma discharge and an underlying contact layer is formed on each of the plate-shaped substrates 60. Subsequently, a DLC film is produced on each of the plate-shaped substrates 60 by injecting a carbon source gas into the chamber 12 such that the internal pressure of the chamber 12 reaches 0.1 to 10 Pa and applying a negative DC pulse voltage having a pulse half width of 0.1 to 3 μsec to each of the plate-shaped substrates 60 to generate plasma. |
| US08945688B2 |
Process of forming a material having nano-particles and a material having nano-particles
A process of forming a material having nano-particles and a material having nano-particles are disclosed. The process includes arranging nano-particles in a predetermined pattern within a matrix material. The material includes arranged nano-particles forming a predetermined pattern in the matrix material. |
| US08945687B2 |
Heat transfer medium and heat transfer method using the same
Disclosed are a heat transfer medium and a heat transfer method that uses the heat transfer medium. The heat transfer medium comprises a light-transparent substrate coated with a plurality of nano particles. The nano particles absorb light incident thereon to thereby produce heat, which is transferred to a target object to be heated. Nano particles can be applied onto a target object. After heating, the particles are removed by etching. Nano particles can be selectively applied to the light-transparent substrate or directly to a target object to be heat so as to localize heat-production and thus heat selective portions of the target object. |
| US08945686B2 |
Method for reducing thin films on low temperature substrates
A method for producing an electrically conductive thin film on a substrate is disclosed. Initially, a reducible metal compound and a reducing agent are dispersed in a liquid. The dispersion is then deposited on a substrate as a thin film. The thin film along with the substrate is subsequently exposed to a pulsed electromagnetic emission to chemically react with the reducible metal compound and the reducing agent such that the thin film becomes electrically conductive. |
| US08945685B2 |
Method for dying and/or printing adhesive closure parts
A method for dying and/or printing adhesive closure parts (10) having a plurality of hooks (12) predominately made of a plastic material connected to a carrier (14), applies a dye medium to the surface (16) of the adhesive closure part (10) or its parts by an application unit (18). Because the dye used is based on a solvent free wax applied by the application unit (18) in a melted form in droplets, bubbles, or pellet form, and enters into a fixed connection to the surface (16) in the cooled, cured state, a wax dye application may be achieved that is markedly colorfast and UV resistant. |
| US08945682B2 |
Deposition apparatus, method for manufacturing organic light emitting display apparatus, and organic light emitting display apparatus
A deposition apparatus includes a first transporting unit configured to transport moving units, to which substrates may be detachably affixed, in a first direction; and a second transporting unit configured to transport empty moving units, from which the respective substrates have been detached, in a return direction opposite to the first direction, wherein the moving units are transported cyclically in reusing fashion. |
| US08945681B2 |
Coating composition comprising autoxidisable component
There is described (pref. non-adhesive) coating compositions (which may be either water or solvent borne) that comprise an autoxidisable vinyl polymer, the autoxidisable polymer having a vinyl polymer backbone 25% to 75% by wt of the autoxidisable polymer; fatty acid residue 25% to 75% by wt of the autoxidisable polymer; Tg from −60° C. to +20° C., Mw from 3500 to 50000 g/mol; and polydispersity from 2 to 10; the autoxidisable polymer obtained by a process of: (A) polymerising ethylenically unsaturated vinyl monomers comprising: at least one epoxy functional vinyl monomer 15% to 100% by wt total monomers in (A); 0 to 85% of at least one other ethylenically unsaturated vinyl monomer, (preferably other than styrenic monomers) by wt total monomers in (A); (B) reacting the epoxy functional polymer from (A) with fatty acids having an average iodine value from 30 to 250 g I2/100 g fatty acid; where composition has: a) a opt. co-solvent content ≦40% by wt of the composition; b) a solids content either ≧30% (aqueous) ≧60% (solvent based) by wt of the composition, the composition as a coating film having a telegraphing value of less than 10 gloss units (difference between an initial smooth gloss minus an initial rough gloss of the film). |
| US08945677B2 |
Electronic device manufacture using low-k dielectric materials
Materials and methods for manufacturing electronic devices and semiconductor components using low dielectric materials comprising polyimide based aerogels are described. Additional methods for manipulating the properties of the dielectric materials and affecting the overall dielectric property of the system are also provided. |
| US08945675B2 |
Methods for forming conductive titanium oxide thin films
The present disclosure relates to the deposition of conductive titanium oxide films by atomic layer deposition processes. Amorphous doped titanium oxide films are deposited by ALD processes comprising titanium oxide deposition cycles and dopant oxide deposition cycles and are subsequently annealed to produce a conductive crystalline anatase film. Doped titanium oxide films may also be deposited by first depositing a doped titanium nitride thin film by ALD processes comprising titanium nitride deposition cycles and dopant nitride deposition cycles and subsequently oxidizing the nitride film to form a doped titanium oxide film. The doped titanium oxide films may be used, for example, in capacitor structures. |
| US08945673B2 |
Nanoparticles with grafted organic molecules
An apparatus for producing grafted Group IV nanoparticles is provided and includes a source of Group IV nanoparticles. A chamber is configured to carry the nanoparticles in a gas phase and has an inlet and an exit. The inlet configured to couple to an organic molecule source which is configured to provide organic molecules to the chamber. A plasma source is arranged to generate a plasma. The plasma causes the organic molecules to break down and/or activate in the chamber and bond to the nanoparticles. A method of producing grafted Group IV nanoparticles is also provided and includes receiving Group IV nanoparticles in a gas phase, creating a plasma with the nanoparticles, and allowing the organic molecules to break down and/or become activated in the plasma and bond with the nanoparticles. |
| US08945671B2 |
Method for producing encapsulated sodium percarbonate particles
A process for producing coated sodium percarbonate particles by spray application of a sodium sulfate-containing aqueous solution onto sodium percarbonate particles in a fluidized bed and simultaneous evaporation of water, wherein sodium sulfate and sodium percarbonate-containing dust is used to prepare the sodium sulfate-containing aqueous solution. |
| US08945668B2 |
Phenoxy resin composition for transparent plastic substrate and transparent plastic substrate using the same
Provided are a phenoxy resin composition for transparent plastic substrate and a transparent plastic substrate using the phenoxy resin composition, capable of effectively substituting for a conventional glass substrate since having excellent thermal and chemical resistance, high adhesiveness, low water infiltration, and a small coefficient of linear thermal expansion. In one general aspect, there is provided a phenoxy resin composition for transparent plastic substrate, including: phenoxy resin having a chemical structure expressed as follows: wherein the n value is 35 to 400. |
| US08945665B2 |
Process for making a dental restoration and resultant apparatus
A process for making a dental restoration includes forming a dental restoration base, selecting a decal representing a natural oral cavity characteristic, and attaching the selected decal to the base. Thereafter, the decal and the dental restoration base are conditioned to create a finished dental restoration having desired oral cavity color and characteristics such as teeth, enamel, dentin, crazing lines, stains, veins, blood vessels, bony coloration, hyper-calcification, mucosal tissue or gum tissue. In an alternative embodiment, the process may include placing a sealant over the decal and at least a portion of the dental restoration base. Additionally, a secondary decal may be attached over the sealant, followed by glazing the secondary decal. |
| US08945653B2 |
Extracted whole corn kernels and improved processed and processable corn produced thereby
A processed corn kernel product is obtained from an extraction process in which: an initial unprocessed whole corn kernel is mixed with water at solids levels of between 10% to 50% kernel/water to form a mixture; the mixture is maintained at a temperature of between 50° C. and 85° C. for at least 30 minutes to form a liquid extract and corn kernels desirably having a moisture content greater than 15% by weight of corn kernel solids; the corn kernels are physically separated from a liquid extract; and the corn kernels are dried until a kernel moisture level of <15% is obtained, produced a processed corn kernel product that retains at least 95% of the weight of the unprocessed corn kernels at the same moisture content (i.e., 15%). The ≦5% extracted material may include, but is not limited to, soluble starches, carbohydrates, proteins, fats, oils, fibers, flavonoids, polyphenols, antioxidants, phenolic acids, dyes/pigments, and the like. |
| US08945651B2 |
Process for preparing Maillard flavour preparations
The present invention relates to a process of producing Maillard flavor preparation, such as process flavors, comprising heating a combination of a carbohydrate source and a nitrogen source in a continuous liquid phase containing at least 10 wt % of an α-hydroxycarboxylic acid component selected from the group of α-hydroxycarboxylic acids according to the following formula (I): R1—CR2(OH)—COOH salts of these acids and combinations thereof. It was found that the flavor preparations so obtained exhibit unique flavor profiles, making them particularly suitable for use in foodstuffs, beverages, pharmaceutics, tobacco products and oral care products. |
| US08945650B2 |
Manufacturing method and manufacturing apparatus for Baumkuchen
There are provided a manufacturing method and a manufacturing apparatus for Baumkuchen for easily and properly suppressing shape distortion of the Baumkuchen caused in a manufacturing process thereof. In manufacturing the Baumkuchen by alternately repeating application of batter around the whole outer circumference of a spit and baking of the applied batter, the batter is scraped off outer circumferences of opposite end portions of the spit before baking only in early stage of manufacturing until the number of repetitions reaches a specified value. As a result, the number of cake layers formed at the opposite end portions of the Baumkuchen is reduced from that at the other portion and outside diameters of the opposite end portions are reduced from a normal outside diameter to thereby suppress partial increase in the outside diameter at the opposite end portions of the Baumkuchen caused by drooping of the batter at the end portions of the spit before baking. |
| US08945647B2 |
Process and an apparatus for preparing a beverage under controlled pressure conditions
A process of preparing a beverage from a beverage preparation chamber includes feeding water to the preparation chamber until a first pressure is reached, interrupting the flow of water to the preparation chamber, holding the preparation chamber in a closed condition for a first time interval, opening the outlet of the preparation chamber and delivering the thus prepared beverage. |
| US08945640B2 |
Genipin-rich material and its use
A method of preparing genipin-rich materials from the fruit of Genipa americana fruit for their use as a cross-linking agent and as a raw material to produce colors is disclosed. The genipin-rich materials can be used in a broad range of applications including personal care, cosmetics, dietary supplements, packaging, textiles, beverages, foodstuffs, drugs, and animal feeds. |
| US08945633B2 |
Pharmaceutical composition for preventing and treating inflammatory diseases containing an ethyl acetate fraction of dried extract of Trachelospermi caulis as an active ingredient, and method for producing the fraction
The present invention relates to a pharmaceutical composition for treating and preventing inflammatory diseases comprising an ethyl acetate fraction of dried extract of Trachelospermi caulis as an active ingredient and a method for producing the fraction. More particularly, the present invention relates to a composition for preventing and treating inflammatory diseases comprising an ethyl acetate fraction of dried extract of Trachelospermi caulis as an active ingredient, in which the extract of Trachelospermi caulis is refined and concentrated to contain 0.05˜12% by weight of arctigenin as an index material, and a method for producing the fraction. |
| US08945632B2 |
Methods and compositions for inhibiting the nuclear factor κB pathway
The current invention provides therapeutic methods which include inhibition of nuclear factor κb pathway in a cell based on the discovery of an active fraction of a plant extract termed NUP or a composition which includes NUP. NUP is used in treating and managing different diseases such as cancer, inflammation, and virus infections. |
| US08945629B2 |
Nanoparticles for cytoplasmic drug delivery to cancer cells
The invention is a nanoparticle that contains an anticancer drug that is released in cancer cells when administered to a subject. The nanoparticles have a core including the anticancer drug and polymer chains that are soluble at the pH of the cancer cell. The core is surrounded by a layer of polymer chains that are insoluble at the pH of healthy tissue but soluble at the pH of the cancer interstitium. An outside layer is made of water-soluble polymer chains to shield the nanoparticle from RES recognition and give the nanoparticle a long circulation time in the bloodstream of the subject. The outside layer may also include folic acid moieties that bind folic acid receptors on the surface of the cancer cell. |
| US08945624B2 |
Photoinitiated tissue filler
Visible light-activated polymer cosmetic filler preparations useful in a variety of applications are provided. In some embodiments, the photo-activated polymer composition comprises a conventional polymeric material, such as HA, together with a modified, crosslinkable polymer, such as PEG or PEODA, to permit the formation of crosslinks within the polymer matrix in situ on exposure to a visible light source, such as an IPL device. The preparations provide for a more stabilized composition that is contourable during gelation. |
| US08945623B2 |
Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use
The invention provides compositions, kits, and methods for treatment of neuronal injury. In one embodiment, the composition comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant. |
| US08945620B2 |
Solid pharmaceutical compositions containing pregabalin
A solid pharmaceutical composition containing pregabalin is described. The composition includes a matrix forming agent and a swelling agent and is suitable for once daily oral administration. Exemplary matrix forming agents include mixtures of polyvinyl acetate and polyvinylpyrrolidone, and exemplary swelling agents include cross-linked polymers of polyvinylpyrrolidone. |
| US08945614B2 |
Oral drug delivery system
Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds. |
| US08945611B2 |
Artificial oxygen carriers and use thereof
The invention relates to dispersions of artificial oxygen carriers, wherein the dispersions contain capsules with reversible oxygen storage capacity, the capsules comprising an oxygen-permeable capsule material, that contains and/or encloses fluorinated, particularly perfluorinated hydrocarbons, preferably perfluorocarbons. The dispersions are particularly suitable as a blood substitute, preferably for the purpose of transfusion, e.g. in states of blood loss of the human or animal body, in particular following surgical interventions, accidents, injuries etc, or for the prophylactic treatment and/or treatment by therapy of ischaemic states or states following a reperfusion. |
| US08945610B2 |
Condensation products based on bicyclic or polycyclic aromatics or heteroaromatics
The invention relates to a condensation product obtainable by reaction of a1) at least one bicyclic or polycyclic aromatic or heteroaromatic, where the bicyclic or polycyclic aromatic or heteroaromatic is substituted by at least one carboxyl group (—COOH), and where the carboxyl group can be present in salt form, a2) at least one carbonyl compound, a3) if appropriate at least one sulfonating agent, a4) at least one urea derivative, and a5) if appropriate at least one further aromatic or heteroaromatic, or a physiologically tolerable salt thereof. |
| US08945606B2 |
Oral adhering disc with dimple on adhering side
A dissolving oral adhering disc (troche) with a dimple on at least one side to improve adhesion to hard convex surfaces in the mouth, including teeth, orthodontic braces, and gums (keratinized gingiva). The disc may be designed to prevent or treat a sore in the mouth opposite a tooth or brace and/or to release a medication into the mouth, to treat such as sore or to treat or prevent conditions elsewhere in the mouth or throat or stomach. |
| US08945603B2 |
Sodium channel blocker delivery system with scleral lens
A scleral lens is provided with a sodium channel blocker or a sodium channel modulator disposed in the pre-corneal tear film between the scleral lens and the cornea. This system can be used to deliver sodium channel blockers or a sodium channel modulators not currently used because of poor bioavailability. Methods of using this sodium channel blocker delivery system or a sodium channel modulator delivery system are also disclosed. |
| US08945601B2 |
System and method for attaching soft tissue to an implant
One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein the porous region exhibits a nano-textured surface, and a biocompatible polymer matrix coating the nano-textured surface. The polymer matrix coating comprises a naturally occurring extracellular matrix with biocompatible inorganic materials distributed within the matrix, or a biocompatible polymer and an osteo-inductive agent. |
| US08945599B2 |
Immobilized biologically active entities having a high degree of biological activity
The present invention relates to immobilized biologically active entities having heparin cofactor II binding activity. |
| US08945597B2 |
Botanical insecticides
The invention generally relates to environmental friendly pesticide compounds, formulations, methods of preparation and application and utilities thereof. More particularly, the invention relates to pesticide compounds and formulations that include terpenes or terpenoids having chemical formula of (C5H8)n, and its derivatives and analogs thereof, as active insecticidal ingredients; certain botanical essential oils as synergists, and other select ingredients as additives. |
| US08945596B2 |
Antimicrobial composition
The present invention relates to an antimicrobial composition. It particularly relates to an antimicrobial composition for cleansing or personal care. It is an object of the present invention to provide antimicrobial compositions that have relatively fast antimicrobial action. Present inventors have surprisingly found that compositions comprising selected ingredients, namely thymol and terpineol, in selective proportions provide relatively quick antimicrobial action. |
| US08945594B2 |
Vinylic mask with peel-off effect for topical use containing high concentrations of retinoic acid
A formulation for topical use having a filmogenic (peel-off) action for professional and home use, containing high concentrations of Retinoic acid, the method of production and use thereof in the treatment of acne, wrinkles, hyperpigmentations, psoriasis and all imperfections linked to keratinization disorders. The composition also comprises octyldodecyl octyldodecanoate, and polyvinyl alcohol. The composition is in the form of a face mask (pack). |
| US08945589B2 |
Immunogenic compositions for Streptococcus agalactiae
This application relates to Group B Streptococcus (“GBS”) vaccines comprising combinations of GBS polypeptide antigens where the polypeptides contribute to the immunological response in a recipient. Preferably, the compositions of the invention comprise a combination of two or more GBS antigens, wherein said combination includes GBS 80 or a fragment thereof. In one embodiment, the combination may consist of two to thirteen GBS antigens selected from an antigen group consisting of GBS 80, GBS 91, GBS 104, GBS 184, GBS 276, GBS 305, GBS 322, GBS 330, GBS 338, GBS 361, GBS 404, GBS 690, and GBS 691. |
| US08945586B2 |
Therapeutic use of the encoding sequence of the carboxy-terminal domain of the heavy chain of the tetanus toxin
The present invention relates to the therapeutic use of the carboxy-terminal domain of the heavy chain of the tetanus toxin for the treatment of amyotrophic lateral sclerosis (ALS). |
| US08945585B2 |
Multi-Target recombination gene and the application of its protein to prevent and cure Helicobacter pylori
The present invention discloses a multi-target recombination gene and the application of its protein to prevent and cure Helicobacter pylori. It includes a multi-target fusion polypeptide having amino acid sequence shown in SEQ ID NO:2, a multi-target recombination gene of encoding multi-target fusion polypeptide having nucleotide sequence shown in SEQ ID NO:1, and the application of the multi-target recombination gene or the multi-target fusion polypeptide or specific antibody of the multi-target fusion polypeptide as biological products for preventing and curing Helicobacter pylori. The present invention effectively combines the key target protein UreI for Hp gastric colonization, and antigen target of UreB to create the best drug target. |
| US08945584B2 |
Cell culture system of a hepatitis C genotype 3a and 2a chimera
A robust and genetically stable cell culture system for Hepatitis C Virus (HCV) genotype 3a is provided. A genotype 3a/2a (S52/JFH1) recombinant containing the structural genes (Core, E1, E2), p7 and NS2 of strain S52 was constructed and characterized in Huh7.5 cells. S52/JFH1 and J6/JFH viruses passaged in cell culture had comparable growth kinetics and yielded similar peak HCV RNA titers and infectivity titers. Direct genome sequencing of cell culture derived S52/JFH1 viruses identified putative adaptive mutations in Core, E2, p7, NS3, and NS5A; clonal analysis revealed that all genomes analyzed exhibited different combinations of these mutations. Finally, viruses resulting from transfection with RNA transcripts of five S52/JFH1 recombinants containing these combinations of putative adaptive mutations performed as efficiently as J6/JFH viruses in Huh7.5 cells and were all genetically stable after viral passage. |
| US08945583B2 |
GLUT-1 as a receptor for HTLV envelopes and its uses
The invention relates to the use of the ubiquitous vertebrate glucose transporter GLUT1, or of fragments or sequences derived thereof, for the in vitro diagnosis of cancers, when used as a tumor marker, or for the screening of compounds useful for the preparation of drugs for the prevention or the treatment of pathologies linked to an infection of an individual with a PTLV, or pathologies linked to an overexpression of GLUT1 on cell surfaces, or the in vitro detection of GLUT1 on cell surfaces. The invention also relates to pharmaceutical compositions containing GLUT1, or fragments or sequences derived thereof, and to their uses such as in the frame of the prevention or the treatment of pathologies linked to an infection of an individual with a PTLV. |
| US08945582B2 |
Vaccine
The standard dose of polio vaccines contains 40 D-antigen units of inactivated poliovirus type 1 (Mahoney), 8 D-antigen units of inactivated poliovirus type 2 (MEF-1), and 32 D-antigens units of inactivated poliovirus type 3 (Saukett). The present invention teaches that reduced doses of inactivated poliovirus can maintain adequate or improved level of protection against polio. |
| US08945580B2 |
Yersinia pestis antigens, vaccine compositions, and related methods
The present invention provides antigens and vaccines useful in prevention of infection by Yersinia pestis. The present invention provides pharmaceutical compositions of such antigens and/or vaccines. The present invention provides methods for the production of Y. pestis protein antigens in plants, as well as methods for their use in the treatment and/or prevention of Y. pestis infection. |
| US08945577B2 |
Fusion proteins and combination vaccines comprising Haemophilus influenzae Protein E and Pilin A
The present invention relates to compositions comprising Haemophilus influenzae Protein E and Pilin A. More particularly, the present application relates to fusion proteins and immunogenic compositions comprising Protein E and PilA, vaccines comprising such immunogenic compositions and therapeutic uses of the same. |
| US08945572B2 |
Methods and compositions for the diagnosis and treatment of cancer
Methods and compositions are provided for the diagnosis and treatment of colorectal cancers associated with amplification or overexpression of the FGFR2 gene. |
| US08945571B2 |
Targeted immunoconjugates
The present invention relates to immunoconjugates. In particular embodiments, the present invention relates to immunoconjugates comprising at least one single-chain effector moiety and two or more antigen binding moieties. In addition, the present invention relates to nucleic acid molecules encoding such immunoconjugates, vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the immunoconjugates of the invention, and to methods of using these immunoconjugates in the treatment of disease. |
| US08945569B2 |
Jagged-binding agents and uses thereof
Antibodies that specifically bind to an extracellular domain of human Jagged 1 or human Jagged2 and modulate Jagged activity, and methods of using said antibodies to inhibit tumor growth are disclosed. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an anti-Jagged antibody to a patient having a tumor or cancer. |
| US08945568B2 |
Pneumococcal Serotype 6D
Disclosed is a new and emerging serotype of Streptococcus pneumoniae designated serotype 6D, and assays and monoclonal antibodies useful in identifying same. Also disclosed is a novel pneumococcal polysaccharide with the repeating unit→2) glucose 1 (1→3) glucose 2 (1→3) rhamnose (1→4) ribitol (5→phosphate. This new serotype may be included in pneumococcal vaccines. |
| US08945567B2 |
Monovalent, bivalent and trivalent anti human respiratory syncytial virus (HRSV) nanobody constructs for the prevention and/or treatment of respiratory tract infections
Amino acid sequences are provided that are directed against and/or that can specifically bind protein F of hRSV, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences, polypeptides and therapeutic compounds and compositions provided by the invention show an improved stability, less immunogenicity and/or improved affinity and/or avidity for protein F of hRSV. The invention also relates to the uses of such amino acid sequences, polypeptides, compounds or constructs for prophylactic and/or therapeutic purposes. |
| US08945566B2 |
Methods for improving the bioactivity of therapeutic IgE antibodies for the treatment of disease
The invention provides a method for increasing the bioactivity (e.g. the biosafety and efficacy) of a therapeutic IgE antibody of the invention in the treatment of a patient. Methods of the invention include: i) administering to the patient a therapeutic IgE antibody in combination with at least one bioactivity-enhancing agent, ii) strategic treatment regimens and protocols for the dosing and administration of a therapeutic IgE antibody of the invention, and iii) the use of a therapeutic IgE antibody having a variable region comprising at least one antigen binding region specific for binding an epitope of an antigen wherein the epitope is not highly repetitive or is non-repetitive. |
| US08945562B2 |
Anti-complement C1s antibodies
The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions. |
| US08945561B2 |
Receptor modulators
Method of identifying a modulator of CD28 comprising comparing a structural model of a candidate modulator with a structural model of CD28 to thereby determine whether the modulator will bind to CD28, wherein the structural model is derived from, or comprises, structural coordinates of a crystal of: (i) CD28, (ii) a fragment of CD28, or (iii) a homolog of (i) or (ii). The crystal of CD28 in a soluble form complexed with the Fab fragment of a mitogenic (superagonistic) antibody has been obtained and used for the determination of the 3D-structure of the receptor. The application also relates to modulators of superagonistic signalling for any receptor of the CD28 family, i.e. to superagonistic antibodies and chimeric proteins thereof, and to the screening of the superagonistic modulators. In the methods of screening, the binding of the candidate modulators to a portion of the receptor proximal to the cell membrane is investigated. |
| US08945558B2 |
Methods for treating myocardial infarction comprising administering an IL-6 inhibitor
The present inventors investigated the effects of anti-IL-6 receptor antibodies on improving the condition of infarcted areas in myocardial infarction, and on suppressing left ventricular remodeling after myocardial infarction. As a result, the administration of anti-IL-6 receptor antibodies significantly suppressed the increase of MPO activity in the infarcted area and suppressed myocardial MCP-1 expression in both the infarcted area and the non-infarcted area. Furthermore, echocardiography and histological examinations revealed that cardiac hypertrophy is also suppressed. |
| US08945557B2 |
Use of immunesuppressant receptor
The present invention relates to use of an antagonist of BIR1 (B cell immunoglobulin receptor 1) related to the present invention, a method for screening the antagonist, in addition to subtype polypeptides of BIR1, the polynucleotide encoding them and antibodies for the polypeptides.BIR1 functions as an immunosuppressive receptor, and the antagonist of BIR1 has immunopotentive activity, which is able to use for preventing and/or treating a cancer, an immunodeficiency disease or an infectious disease. |
| US08945550B2 |
Antibodies and methods for making and using them
The invention provides antibodies, including chimeric human antibodies, recombinant antibodies, synthetic anti-bodies, and the nucleic acids encoding them, and methods for making and using these immunoglobulins. The invention provides recombinant and synthetic polypeptide and nucleic acid embodiments of these polypeptides and/or antibodies. The invention also provides polypeptides comprising, or consisting of, consensus human framework regions, or “Independently Consensused Frameworks (ICFs)”, nucleic acids encoding them, and libraries and kits comprising these ICFs and/or antibodies of the invention, individually and in combinatorial libraries and combinations. |