最新美国发明专利
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US08946942B2 Robust semiconductor power devices with design to protect transistor cells with slower switching speed
This invention discloses a power switch that includes a fast-switch semiconductor power device and a slow-switch semiconductor power device controllable to turn on and off a current transmitting therethrough. The slow-switch semiconductor power device further includes a ballasting resistor for increasing a device robustness of the slow switch semiconductor power device. In an exemplary embodiment, the fast-switch semiconductor power device includes a fast switch metal oxide semiconductor field effect transistor (MOSFET) and the slow-switch semiconductor power device includes a slow switch MOSFET wherein the slow switch MOSFET further includes a source ballasting resistor.
US08946941B2 Wireless power and data transfer device for harsh and extreme environments
A wireless power and data connector includes a socket and a plug. The socket has a power port for connecting to a wired power transmission line, a data port for connecting to a wired data communication line, a wireless power transmitter, and a wireless data transceiver. The plug includes a power port for connecting to a wired instrument power transmission line, a data port for connecting to a wired instrument data communication line, a wireless power receiver, and a wireless data transceiver. The socket has a concave portion and the plug has a convex region shaped such that the convex region of the plug removably fits within the concave region of the socket. The wireless power transmitter and wireless power receiver transmit power from the socket to the plug using magnetically coupled resonant tank circuits.
US08946934B2 Low-cost connector apparatus and methods for use in high-speed data applications
Low-cost connector apparatus for passing electrical signals from one device over another via a cable. In one embodiment, the connector apparatus comprises a coaxial type connector that mates with a host device, such as via the motherboard thereof. In one variant, the connector further comprises a plurality of electrical components including an integrated circuit adapted to condition (e.g., equalize) the signals being transmitted over the cable. The connector (and hence internal electrical components) is shielded so as to mitigate the effects of EMI or RFI on the host device circuitry itself. In another variant, the signals comprise IEEE-Std. 1394 “FireWire” high speed data signals, and the use of the shielded connector in the signal pathway allows the use of lower cost cabling than would otherwise be required with a non-shielded (non-integrated) connector.
US08946933B2 Power management apparatus and method of operating the same
A power management apparatus and a method of operating the same are disclosed. The power management apparatus includes a power conversion unit, a first sensing unit, a second sensing unit, a switch unit, and a control unit. The power conversion unit converts output power generated from at least one renewable energy generation apparatus. The first sensing unit is provided to sense a first current and a first voltage and the second sensing unit is provided to sense a second current and a second voltage. The control unit acquires an output power generated from the renewable energy generation apparatus and acquires a feedback power to an AC utility according to the currents and the voltages when the control unit turns on the switch unit.
US08946932B2 Configurable distributed power module
The present invention provides a configurable dc-dc power converter module and method of manufacture for such module. The power converter module comprises an isolated subassembly with a capacitor bank, control circuits and an isolated power train that converts an input voltage to an intermediate bus voltage. The power module further comprises multiple non-isolated power trains electrically coupled to the isolated subassembly that are powered by the intermediate bus voltage to produce output voltages. The number of output voltages is determined by the number of populated non-isolated power trains, which may include all of the non-isolated power trains in the power module or a subset thereof. In one embodiment of the invention the non-isolated power trains are located on a carrier PWB that is electrically coupled to the bus PWB.
US08946929B2 Method and apparatus for effective utilization of energy storage components within a microgid
A method for effectively utilizing energy storage components within a microgrid may include the steps of connecting a first plurality of energy storage components to a DC bus through switches, connecting a second plurality of energy storage components to an AC bus through inverters, connecting controllers to the energy storage components, connecting a first plurality of the controllers to the DC bus to regulate bidirectional flow of energy between the DC bus and the first plurality of energy storage components and connecting a second plurality of the controllers to the AC bus to regulate bidirectional flow of energy between the AC bus and the second plurality of energy storage components. The controllers may be interconnected with a local energy storage system bus and controlled via a master microgrid controller connected to the local energy storage system bus. The controllers may have a state of charge and a state of health algorithm adapted to measure the state of charge and the state of health of the energy storage components under dynamic charge or discharge conditions.
US08946928B2 Power distribution system and method thereof
The proposed system has a plurality of generator systems, each generator system having an alternating current generator directly connected to a rectifier. The alternating current generator is rotationally coupled to a prime mover, wherein, upon operation of the prime mover, the alternating current generator produces an alternating current output , is de-synchronized to further ones of the plurality of generator systems and has a variable generator speed. The rectifier directly connected the alternating current generator is adapted to convert the alternating current output of the alternating current generator into a direct current output. A direct current distribution bus is coupled to the direct current outputs from each of the rectifiers. The system further has a plurality of inverters adapted to receive power from the direct current distribution bus, the output of each inverter being adapted to drive an alternating current motor.
US08946919B2 Linear faraday induction generator for the generation of electrical power from ocean wave kinetic energy and arrangements thereof
Various embodiments of linear electric generators and arrangements thereof are disclosed. One such generator includes a permanent magnetic array with magnets that are oriented such that like poles of the magnets are disposed adjacently to concentrate a magnetic field through a coil array. To enhance the magnetic field distribution, the magnets are affixed under a compressive strain due to repulsive forces resulting from proximity of the like poles. According to another aspect, a plurality of vibrational linear electric generators (VLEGs) can be arranged so that magnets of different VLEGs are oriented so that poles of opposite polarity are disposed adjacently to further enhance magnetic field concentration through coil arrays. In addition, a plurality of wave energy converters can be arranged in very close proximity, at most 8 times a height of a buoyant portion of the converters, to act as a seawall and thereby protect various structures from ocean waves.
US08946918B1 Modular in-conduit generator for harnessing energy from circumferential flow
An electrical generator module for harnessing the energy of fluid flowing in a channel subject to gravitational and centripetal forces. The electrical generator module includes a stationary casing portion and a runner portion rotationally coupled to the stationary casing portion, with the runner portion including a set of blades adapted to interact with the fluid. A support arrangement is adapted to secure the stationary casing portion to the interior of the channel in place such that it is prevented from rotating. An electrical energy generator is mechanically coupled to the runner portion and adapted to convert rotational motion of the runner portion into electrical energy.
US08946917B2 Method for controlling power flow within a wind park system, controller, computer program and computer program products
A method is provided for controlling power flow within a wind park system for power transmission to a main power grid, the wind park system including two or more parallel-connected island wind park grids. The method includes the steps of: controlling a first voltage source converter as a swing bus in frequency control, the frequency control including controlling frequency to a steady state reference operating point for operating points within a power dead band and by frequency droop control when exceeding an end point of the power dead band, and controlling at least a second voltage source converter in power control, the power control including controlling power flow to a steady state reference operating point for operating points within a frequency dead band and by power droop control when exceeding an end point of the frequency dead band. A controller and computer program product are also provided.
US08946914B2 Contact power rail
A method for forming CA power rails using a three mask decomposition process and the resulting device are provided. Embodiments include forming a horizontal diffusion CA power rail in an active layer of a semiconductor substrate using a first color mask; forming a plurality of vertical CAs in the active layer using second and third color masks, the vertical CAs connecting the CA power rail to at least one diffusion region on the semiconductor substrate, spaced from the CA power rail, wherein each pair of CAs formed by one of the second and third color masks are separated by at least two pitches.
US08946911B2 Electrode pad, printed circuit board using the same, and method of manufacturing printed circuit board
There is provided an electrode pad including: a connection terminal part; a first plating layer including palladium phosphorus (Pd—P) formed on the connection terminal part; and a second plating layer including palladium (Pd) formed on the first plating layer.
US08946907B2 Self-aligned nano-structures
A method for creating structures in a semiconductor assembly is provided. The method includes etching apertures into a dielectric layer and applying a polymer layer over the dielectric layer. The polymer layer is applied uniformly and fills the apertures at different rates depending on the geometry of the apertures, or on the presence or absence of growth accelerating material. The polymer creates spacers for the etching of additional structure in between the spacers. The method is capable of achieving structures smaller than current lithography techniques.
US08946906B2 Multilayer wiring substrate and method of manufacturing the same
To provide a multilayer wiring substrate in which the connection reliability of via conductors is enhanced, via holes are formed in a resin interlayer insulation layer which isolates a lower conductor layer from an upper conductor layer, and via conductors are formed in the via holes for connecting the lower conductor layer and the upper conductor layer. The surface of the resin interlayer insulation layer is a rough surface, and the via holes open at the rough surface of the resin interlayer insulation layer. Stepped portions are formed in opening verge regions around the via holes such that the stepped portions are recessed from peripheral regions around the opening verge regions. The stepped portions are higher in surface roughness than the peripheral regions.
US08946902B2 Device and method for manufacturing a device
A device includes a semiconductor chip including a frontside, a backside, and a side surface extending from the backside to the frontside. The side surface includes a first region and a second region, wherein a level of the first region is different from a level of the second region. The device further includes an electrically conductive material arranged over the backside of the semiconductor chip and over the first region of the side surface, wherein the second region of the side surface is uncovered by the electrically conductive material.
US08946900B2 X-line routing for dense multi-chip-package interconnects
X-line routing arrangements for dense multi-chip-package interconnects are described. In an example, an electronic signal routing structure includes a substrate. A plurality of layers of conductive traces is disposed above the substrate. A first pair of ground traces is disposed in a first of the plurality of layers of conductive traces. A signal trace is disposed in a second of the plurality of layers of conductive traces, below the first layer. A second pair of ground traces is disposed in a third of the plurality of layers of conductive traces, below the first layer. The first and second pairs of ground traces and the signal trace provide an X-pattern routing from a cross-sectional perspective.
US08946896B2 Extended liner for localized thick copper interconnect
A dielectric layer overlies a semiconductor substrate. The substrate has components and appropriate contacts formed therein. The dielectric layer electrically insulates the substrate and components from overlying conductive interconnect layers. A barrier layer is arranged over the dielectric layer to isolate the interconnect layers from other structures. A copper layer is then deposited over the barrier layer and thick interconnect lines having a first width and a first height are realized. Then, the barrier layer is etched using one of many alternative techniques. The barrier layer has a second width and a second height wherein the second width of the barrier liner is selected to be greater than the first width of the thick copper interconnect.
US08946894B2 Package for high-power semiconductor devices
Methods and apparatuses for forming a package for high-power semiconductor devices are disclosed herein. A package may include a plurality of distinct thermal spreader layers disposed between a die and a metal carrier. Other embodiments are described and claimed.
US08946893B2 Apparatus for dicing interposer assembly
Apparatus for performing dicing of die on wafer interposers. Apparatuses are disclosed for use with the methods of dicing an interposer having integrated circuit dies mounted thereon. An apparatus includes a wafer carrier mounted in a frame and having a size corresponding to a silicon interposer, a fixture mounted to the wafer carrier and comprising a layer of material to provide mechanical support to the die side of the silicon interposer, the fixture being patterned to fill spaces between integrated circuit dies mounted on an interposer; and an adhesive tape disposed on a surface of the fixture for adhering to the surface of a silicon interposer. Additional alternative apparatuses are disclosed.
US08946890B2 Power/ground layout for chips
Embodiments of the present disclosure provide a chip that comprises a base metal layer formed over a first semiconductor die and a first metal layer formed over the base metal layer. The first metal layer includes a plurality of islands configured to route at least one of (i) a ground signal or (ii) a power signal in the chip. The chip further comprises a second metal layer formed over the first metal layer. The second metal layer includes a plurality of islands configured to route at least one of (i) the ground signal or (ii) the power signal in the chip.
US08946888B2 Package on packaging structure and methods of making same
A package on packaging structure provides for improved thermal conduction and mechanical strength by the introduction of a sold thermal coupler between the first and second packages. The first package has a first substrate and through vias through the first substrate. A first set of conductive elements is aligned with and coupled to the through vias of the first substrate. A solid thermal coupler is coupled to the first set of conductive elements and to a die of the second package. A second set of conductive elements is coupled to the die and a bottom substrate is coupled to the second set of conductive elements. The thermal coupler may be, e.g., an interposer, a heat spreader, or a thermal conductive layer.
US08946887B1 3DIC packages with heat dissipation structures
A package includes a first die and a second die underlying the first die and in a same first die stack as the first die. The second die includes a first portion overlapped by the first die, and a second portion not overlapped by the first die. A first Thermal Interface Material (TIM) is over and contacting a top surface of the first die. A heat dissipating lid has a first bottom surface contacting the first TIM. A second TIM is over and contacting the second portion of the second die. A heat dissipating ring is over and contacting the second TIM.
US08946885B2 Semiconductor arrangement and method for producing a semiconductor arrangement
A semiconductor arrangement includes a ceramic mount and at least one semiconductor component fixed-to the ceramic mount. The ceramic mount includes a first section, and the first section is electrically conductive.
US08946884B2 Substrate-less interposer technology for a stacked silicon interconnect technology (SSIT) product
A substrate-less interposer for a stacked silicon interconnect technology (SSIT) product, includes: a plurality of metallization layers, at least a bottom most layer of the metallization layers comprising a plurality of metal segments, wherein each of the plurality of metal segments is formed between a top surface and a bottom surface of the bottom most layer of the metallization layers, and the metal segments are separated by dielectric material in the bottom most layer; and a dielectric layer formed on the bottom surface of the bottom most layer, wherein the dielectric layer includes one or more openings for providing contact to the plurality of metal segments in the bottom most layer.
US08946883B2 Wafer level fan-out package with a fiducial die
A wafer level fan-out package with a fiducial die is disclosed and may include a semiconductor die and a transparent fiducial die both encapsulated in a molding compound resin, passivation layers on an upper surface and a lower surface of the molding compound resin except where redistribution layers are formed on upper and lower surfaces of the molding compound resin, and a metal pattern on a lower surface of the transparent fiducial die that is visible through an exposed upper surface of the transparent fiducial die. The pattern may comprise a standard coordinate for forming a through mold via utilizing laser drilling.
US08946882B2 Semiconductor module and semiconductor device
A semiconductor module includes at least one intermediate plate which has heat conductivity, power semiconductor elements which are provided for respective main surfaces of the intermediate plate, heat sinks which are arranged so that the power semiconductor elements are held between the heat sinks and the intermediate plate, and a mold part which seals the intermediate plate, the power semiconductor elements, and the heat sinks with mold resin. Surfaces of the heat sinks opposite to the side of the power semiconductor elements are exposed from the mold part. The intermediate plate has an intermediate radiator which projects in the direction parallel to the main surface from the mold part.
US08946880B2 Packaged semiconductor device having multilevel leadframes configured as modules
A semiconductor system (100) has a first planar leadframe (101) with first leads (102) and pads (103) having attached electronic components (120), the first leadframe including a set of elongated leads (104) bent at an angle away from the plane of the first leadframe; a second planar leadframe (110) with second leads (112) and pads (113) having attached electronic components (114); the bent leads of the first leadframe conductively connected to the second leadframe, forming a conductively linked 3-dimensional network between components and leads in two planes; and packaging material (140) encapsulating the 3-dimensional network.
US08946875B2 Packaged semiconductor devices including pre-molded lead-frame structures, and related methods and systems
A packaged semiconductor device includes at least first and second lead-fingers. A molded structure forms a cavity and is molded around portions of each of the first and second lead-fingers to thereby mechanically attach each of the first and second lead-fingers to the molded structure. A semiconductor structure (e.g., a IC, chip or die) is attached within the cavity. First and second bond wires respectively providing electrical connections between the semiconductor structure and the first and second lead-fingers. A further portion of each of the first and second lead-fingers is mechanically attached to a bottom surface of the semiconductor structure to inhibit relative mechanical motion between the semiconductor structure, the molded structure and the first and second lead-fingers.
US08946874B2 IC in-process solution to reduce thermal neutrons soft error rate
Integrated Circuits and methods for reducing thermal neutron soft error rate (SER) of a digital circuit are provided by doping a protection layer on top of the metal layer and in physical contact with the metal layer of the digital circuit, wherein the protection layer is doped with additional thermal neutron absorbing material. The thermal neutron absorbing material can be selected from the group consisting of Gd, Sm, Cd, B, and combinations thereof. The protection layer may comprise a plurality of sub-layers among which a plurality of them containing additional thermal neutron absorbing material.
US08946870B2 Semiconductor device and method of forming stepped interconnect layer for stacked semiconductor die
A semiconductor die has a first semiconductor die mounted to a carrier. A plurality of conductive pillars is formed over the carrier around the first die. An encapsulant is deposited over the first die and conductive pillars. A first stepped interconnect layer is formed over a first surface of the encapsulant and first die. The first stepped interconnect layer has a first opening. A second stepped interconnect layer is formed over the first stepped interconnect layer. The second stepped interconnect layer has a second opening. The carrier is removed. A build-up interconnect structure is formed over a second surface of the encapsulant and first die. A second semiconductor die over the first semiconductor die and partially within the first opening. A third semiconductor die is mounted over the second die and partially within the second opening. A fourth semiconductor die is mounted over the second stepped interconnect layer.
US08946869B2 Integrated circuit for detecting defects of through chip via
An integrated circuit that detects whether a through silicon via has defects or not, at a wafer level. The integrated circuit includes a semiconductor substrate, a through silicon via configured to be formed in the semiconductor substrate to extend to a certain depth from the surface of the semiconductor substrate, an output pad, and a current path providing unit configured to provide a current, flowing between the semiconductor substrate and the through silicon via, to the output pad during a test mode.
US08946868B2 Multiple die layout for facilitating the combining of an individual die into a single die
A semiconductor wafer including a plurality of die fabricated therein in a defined pattern. They are separated from each other by a dicing area or street and at least a portion of adjacent die on the wafer include at least a conductive connection between given adjacent die that is electrically interfaced to circuitry disposed on the given adjacent die.
US08946865B2 Gallium—nitride-on-handle substrate materials and devices and method of manufacture
A gallium and nitrogen containing substrate structure includes a handle substrate member having a first surface and a second surface and a transferred thickness of gallium and nitrogen material. The structure has a gallium and nitrogen containing active region grown overlying the transferred thickness and a recessed region formed within a portion of the handle substrate member. The substrate structure has a conductive material formed within the recessed region configured to transfer thermal energy from at least the transferred thickness of gallium and nitrogen material.
US08946863B2 Epitaxial substrate for electronic device comprising a high resistance single crystal substrate on a low resistance single crystal substrate, and method of manufacturing
An epitaxial substrate for electronic devices, in which current flows in a lateral direction and of which warpage configuration is properly controlled, and a method of producing the same. The epitaxial substrate for electronic devices is produced by forming a bonded substrate by bonding a low-resistance Si single crystal substrate and a high-resistance Si single crystal substrate together; forming a buffer as an insulating layer on a surface of the bonded substrate on the high-resistance Si single crystal substrate side; and producing an epitaxial substrate by epitaxially growing a plurality of III-nitride layers on the buffer to form a main laminate. The resistivity of the low-resistance Si single crystal substrate is 100 Ω·cm or less, and the resistivity of the high-resistance Si single crystal substrate is 1000 Ω·cm or more.
US08946857B2 Semiconductor device for effectively disperse heat generated from heat generating device
A semiconductor device includes a semiconductor substrate, a heat generating device, and a heat radiating part. The heat generating device is provided on the semiconductor substrate, and the heat radiating part is provided above the heat generating device. The heat radiating part is thermally coupled with the semiconductor substrate through at least one contact part.
US08946856B2 Decoupling capacitors for integrated circuits
On-chip decoupling capacitors and methods for placing the same are disclosed in which designated spaces are created between the active circuits to insert designated capacitor cells. The designated capacitor cells may be placed in designated areas of the integrated circuit that are not simply spaces left empty by cell placement or frontier areas in or around the route, and the dimensions (e.g., height) of the designated capacitor cells may be selected to optimize (increase) capacitance efficiency. The capacitor cells may also be placed to target and reduce the interference between a digital core (aggressor) circuit and a victim analog circuit.
US08946855B2 Semiconductor device and method for manufacturing the same
A semiconductor device and a method for manufacturing the same are disclosed. The semiconductor device includes adjacent storage node contact plugs having different heights, and lower-electrode bowing profiles having different heights, such that a spatial margin between the lower electrodes is assured and a bridge fail is prevented, resulting in improved device operation characteristics. The semiconductor device includes a first storage node contact plug and a second storage node contact plug formed over a semiconductor substrate, wherein the second storage node contact plug is arranged at a height different from that of the first storage node contact plug, and a lower electrode formed over the first storage node contact plug and the second storage node contact plug.
US08946854B2 Metal-insulator-metal capacitor structure and method for manufacturing the same
A metal-insulator-metal (MIM) capacitor structure includes a first dielectric layer, a first damascene electrode layer, an insulating barrier layer, a second dielectric layer and a second damascene electrode layer. The first damascene electrode layer is formed in the first dielectric layer. The insulating barrier layer covers the first dielectric layer and the first damascene electrode layer, and is a single layer structure. The second dielectric layer is formed on the insulating barrier layer. The second damascene electrode layer is formed in the second dielectric layer and is contacted with the insulating barrier layer. The MIM capacitor structure can includes a dual damascene structure formed in the second dielectric layer and the insulating barrier layer and electrically connected to the first damascene electrode layer. A method for manufacturing the MIM capacitor structure is also provided.
US08946853B2 Diffusion sidewall for a semiconductor structure
A method of forming diffusion sidewalls in a semiconductor structure and a semiconductor structure having diffusion sidewalls includes etching a trench into a semiconductor substrate to form first and second active regions, lining each trench with an oxide liner along exposed sidewalls of an active silicon region (RX) of the first and second active regions, removing the oxide liner formed along the exposed sidewalls of the RX region of one of the first and second active regions, forming diffusion sidewalls by epitaxially growing in-situ doped material within the exposed sidewalls of the RX region of the one of the first and second active regions, and forming an isolation region within the trench between the first and second active regions to electrically isolate the first and second active regions from each other.
US08946850B2 Integrated circuit including a power transistor and an auxiliary transistor
In one embodiment of an integrated circuit, the integrated circuit includes a power transistor with a power control terminal, a first power load terminal and a second power load terminal. The integrated circuit further includes an auxiliary transistor with an auxiliary control terminal, a first auxiliary load terminal and a second auxiliary load terminal. The first auxiliary load terminal is electrically coupled to the power control terminal. The integrated circuit further includes a capacitor with a first capacitor electrode, a second capacitor electrode and a capacitor dielectric layer. The capacitor dielectric layer includes at least one of a ferroelectric material and a paraelectric material. The first capacitor electrode is electrically coupled to the auxiliary control terminal.
US08946848B2 Apparatus and method for image sensor with carbon nanotube based transparent conductive coating
A backside illuminated image sensor has a carbon nanotube transparent conductive coating formed on the backside of the image sensor. In one implementation the carbon nanotube transparent conductive coating acts as a wavelength selective filter to filter out infrared light. In one implementation the carbon nanotube transparent conductive coating has an optical transparency between 50% and 80% for blue and green color bands.
US08946846B2 Thin film photovoltaic panels and repair methods
Conductive layer(s) in a thin film photovoltaic (TFPV) panel are divided by first scribe curves into photovoltaic cells connected in series. At least one of the layers is scribed to isolate a shunt defect in a cell from parts of that cell away from the defect. The isolation scribes can substantially follow or parallel current-flow lines established by the design of the panel. A TFPV panel can be altered by, using a controller, automatically locating a shunt defect and scribing at least one of the conductive layers along two spaced-apart second scribe curves. Each second scribe curve can intersect the two first scribe curves that bound the cell with the defect. The two second scribe curves can be on opposite sides of the defect.
US08946844B2 Integration of a titania layer in an anti-reflective coating
A stack of a first anti-reflective coating (ARC) layer and a titanium layer is formed on a front surface of a semiconductor substrate including a p-n junction, and is subsequently patterned so that a semiconductor surface is physically exposed in metal contact regions of the front surface of the semiconductor substrate. The remaining portion of the titanium layer is converted into a titania layer by oxidation. A metal layer is plated on the metal contact regions, and a copper line is subsequently plated on the metal layer or a metal semiconductor alloy derived from the metal layer. A second ARC layer is deposited over the titania layer and the copper line, and is subsequently patterned to provide electrical contact to the copper line.
US08946839B1 Reduced volume infrared detector
An absorber is disclosed. The disclosed absorber contains a base layer, and a plurality of pillars disposed above the base layer and composed of material configured to absorb an incident light and generate minority electrical carriers and majority electrical carrier, wherein the height of the pillars is predetermined to provide a common pyramidal outline shared by the pillars in the plurality of pillars.
US08946830B2 Metal oxide protective layer for a semiconductor device
Embodiments related to metal oxide protective layers formed on a surface of a halogen-sensitive metal-including layer present on a substrate processed in a semiconductor processing reactor are provided. In one example, a method for forming a metal oxide protective layer is provided. The example method includes forming a metal-including active species on the halogen-sensitive metal-including layer, the metal-including active species being derived from a non-halogenated metal oxide precursor. The example method also includes reacting an oxygen-containing reactant with the metal-including active species to form the metal oxide protective layer.
US08946827B2 Semiconductor device
Disclosed is a semiconductor device. The semiconductor device includes a functional circuit having a resistor formed by a plurality of polysilicon resistors, and in which the property of the functional circuit can be adjusted by trimming the resistor, and in which the polysilicon resistors are coupled in series or in parallel to each other and arranged in a direction perpendicular to one side of the semiconductor device.
US08946826B2 Semiconductor device
A well potential supply region is provided in an N-type well region of a cell array. Adjacent gates disposed in both sides of the well potential supply region in the horizontal direction and adjacent gates disposed in further both sides thereof are disposed at the same pitch. In addition, an adjacent cell array includes four gates each of which is opposed to the adjacent gates in the vertical direction. In other words, regularity in the shape of the gate patterns in the periphery of the well potential supply region is maintained.
US08946825B2 Integrated circuit structure to resolve deep-well plasma charging problem and method of forming the same
During various processing operations, ions from process plasma may be transfer to a deep n-well (DNW) formed under devices structures. A reverse-biased diode may be connected to the signal line to protect a gate dielectric formed outside the DNW and is connected to the drain of the transistor formed inside the DNW.
US08946824B2 Semiconductor device
A standard cell has gate patterns extending in Y direction and arranged at an equal pitch in X direction. End portions of the gate patterns are located at the same position in Y direction, and have an equal width in X direction. A diode cell is located next to the standard cell in Y direction, and includes a plurality of opposite end portions formed of gate patterns that are opposed to the end portions, in addition to a diffusion layer which functions as a diode.
US08946823B2 Electrostatic discharge protection element and electrostatic discharge protection chip and method of producing the same
An electrostatic discharge (ESD) protection element includes a collector area, a first barrier area, a semiconductor area, a second barrier area and an emitter area. The collector area has a first conductivity type. The first barrier area borders on the collector area and has a second conductivity type. The semiconductor area borders on the first barrier area and is an intrinsic semiconductor area, or has the first or second conductivity type and a dopant concentration which is lower than a dopant concentration of the first barrier area. The second barrier area borders on the semiconductor area and has the second conductivity type and a higher dopant concentration than the semiconductor area. The emitter area borders on the second barrier area and has the first conductivity type.
US08946822B2 Apparatus and method for protection of precision mixed-signal electronic circuits
Apparatus and methods for precision mixed-signal electronic circuit protection are provided. In one embodiment, an apparatus includes a p-well, an n-well, a poly-active diode structure, a p-type active region, and an n-type active region. The poly-active diode structure is formed over the n-well, the p-type active region is formed in the n-well on a first side of the poly-active diode structure, and the n-type active region is formed along a boundary of the p-well and the n-well on a second side of the poly-active diode structure. During a transient electrical event the apparatus is configured to provide conduction paths through and underneath the poly-active diode structure to facilitate injection of carriers in the n-type active region. The protection device can further include another poly-active diode structure formed over the p-well to further enhance carrier injection into the n-type active region.
US08946820B2 Method for manufacturing semiconductor substrate, substrate for forming semiconductor substrate, stacked substrate, semiconductor substrate, and electronic device
Film thickness variations are prevented in a plurality of single crystal semiconductor films separated at a fragile layer reliably and transferred to a base substrate. A method for manufacturing a SOI substrate (33) in which a plurality of SOI layers (15) are disposed on a base substrate (30) includes the steps of bonding a plurality of SOI wafers (10), in which an oxide film (14), a SOI layer (15), a BOX layer (12), and a Si support substrate (13) having a fragile layer (17) formed by ion irradiation in the inside and being made from a single crystal semiconductor material are stacked sequentially, to a base substrate (30) in such a way that the oxide film (14) is located on the side close to the base substrate (30), applying heat to the plurality of SOI wafers (10) to separate part of the Si support substrate (13) at the fragile layer (17) and transfer the oxide film (14), the SOI layer (15), the BOX layer (12), and a single crystal Si layer (18) which is part of the Si support substrate (13) to the base substrate (30), and subjecting the base substrate (30) to an etch back treatment to expose the BOX layer (12) by etching the transferred single crystal Si layer (18).
US08946813B2 Switching element
In a switching element, a first region that is exposed on an upper surface of a semiconductor substrate, a second region that is exposed on the upper surface of the substrate and extends to below the first region, and a third region that is formed below the second region, are formed on the substrate. A trench is formed in the upper surface of the substrate. A gate electrode has a first portion that extends from a depth of the first region to a depth of the third region at at least a portion in the trench formed in an area where the first region is exposed, and a second portion that is formed to a depth of the second region, and does not reach the depth of the third region, at at least a portion in the trench formed in an area where the second region is exposed.
US08946811B2 Body-tied, strained-channel multi-gate device and methods of manufacturing same
A fin-FET or other multi-gate transistor is disclosed. The transistor comprises a semiconductor substrate having a first lattice constant, and a semiconductor fin extending from the semiconductor substrate. The fin has a second lattice constant, different from the first lattice constant, and a top surface and two opposed side surfaces. The transistor also includes a gate dielectric covering at least a portion of said top surface and said two opposed side surfaces, and a gate electrode covering at least a portion of said gate dielectric. The resulting channel has a strain induced therein by the lattice mismatch between the fin and the substrate. This strain can be tuned by selection of the respective materials.
US08946810B2 Ultrahigh density vertical NAND memory device
Monolithic, three dimensional NAND strings include a semiconductor channel, at least one end portion of the semiconductor channel extending substantially perpendicular to a major surface of a substrate, a plurality of control gate electrodes having a strip shape extending substantially parallel to the major surface of the substrate, the blocking dielectric comprising a plurality of blocking dielectric segments, a plurality of discrete charge storage segments, and a tunnel dielectric located between each one of the plurality of the discrete charge storage segments and the semiconductor channel.
US08946808B2 Semiconductor device and method of manufacturing the same
A semiconductor device includes word lines and interlayer insulating layers alternately stacked over a substrate, vertical channel layers protruding from the substrate and passing through the word lines and the interlayer insulating layers, a tunnel insulating layer surrounding each of the vertical channel layers, a charge trap layer surrounding the tunnel insulating layer, wherein first regions of the charge trap layer between the tunnel insulating layer and the word lines have a thickness smaller than a thickness of second regions thereof between the tunnel insulating layer and the interlayer insulating layers, and first charge blocking layer patterns surrounding the first regions of the charge trap layer.
US08946800B2 Semiconductor device with protective layer and method of manufacturing same
To provide a semiconductor device featuring reduced variation in capacitor characteristics. In the semiconductor device, a protective layer is provided at the periphery of the upper end portion of a recess (hole). This protective layer has a dielectric constant higher than that of an insulating layer placed in the same layer as the protective layer and configuring a multilayer wiring layer placed in a logic circuit region.
US08946795B2 Backside-illuminated (BSI) image sensor with reduced blooming and electrical shutter
Embodiments of a pixel including a photosensitive region formed in a surface of a substrate and an overflow drain formed in the surface of the substrate at a distance from the photosensitive area, an electrical bias of the overflow drain being variable and controllable. Embodiments of a pixel including a photosensitive region formed in a surface of a substrate, a source-follower transistor coupled to the photosensitive region, the source-follower transistor including a drain, and a doped bridge coupling the photosensitive region to the drain of the source-follower transistor.
US08946784B2 Method and apparatus for image sensor packaging
A backside illuminated image sensor having a photodiode and a first transistor in a sensor region and located in a first substrate, with the first transistor electrically coupled to the photodiode. The image sensor has logic circuits formed in a second substrate. The second substrate is stacked on the first substrate and the logic circuits are coupled to the first transistor through bonding pads, the bonding pads disposed outside of the sensor region.
US08946776B2 Semiconductor device with selectively etched surface passivation
A semiconductor device includes a semiconductor substrate configured to include a channel, a gate supported by the semiconductor substrate to control current flow through the channel, a first dielectric layer supported by the semiconductor substrate and including an opening in which the gate is disposed, and a second dielectric layer disposed between the first dielectric layer and a surface of the semiconductor substrate in a first area over the channel. The second dielectric layer is patterned such that the first dielectric layer is disposed on the surface of the semiconductor substrate in a second area over the channel.
US08946765B2 Gallium nitride devices
Semiconductor structures comprising a III-nitride (e.g., gallium nitride) material region and methods associated with such structures are provided. In some embodiments, the structures include an electrically conductive material (e.g., gold) separated from certain other region(s) of the structure (e.g., a silicon substrate) by a barrier material in order to limit, or prevent, undesirable reactions between the electrically conductive material and the other component(s) which can impair device performance. In certain embodiments, the electrically conductive material may be formed in a via. For example, the via can extend from a topside of the device to a backside so that the electrically conductive material connects a topside contact to a backside contact. The structures described herein may form the basis of a number of semiconductor devices including transistors (e.g., FET), Schottky diodes, light-emitting diodes and laser diodes, amongst others.
US08946763B2 Semiconductor light-emitting device
A semiconductor light-emitting device includes a lead frame, a semiconductor light-emitting element mounted on the top surface of the bonding region, and a case covering part of the lead frame. The bottom surface of the bonding region is exposed to the outside of the case. The lead frame includes a thin extension extending from the bonding region and having a top surface which is flush with the top surface of the bonding region. The thin extension has a bottom surface which is offset from the bottom surface of the bonding region toward the top surface of the bonding region.
US08946755B2 Light-emitting devices having multiple encapsulation layers with at least one of the encapsulation layers including nanoparticles and methods of forming the same
A light-emitting device includes an active region that is configured to emit light responsive to a voltage applied thereto. A first encapsulation layer at least partially encapsulates the active region and includes a matrix material and nanoparticles, which modify at least one physical property of the first encapsulation layer. A second encapsulation layer at least partially encapsulates the first encapsulation layer.
US08946753B2 Light emitting diode
A light emitting diode including a substrate, a first semiconductor layer, an active layer, and a second semiconductor layer is provided. The first semiconductor layer includes a first surface and a second surface, and the first surface is connected to the substrate. The active layer and the second semiconductor layer are stacked on the second surface in that order, and a surface of the second semiconductor layer away from the active layer is configured as the light emitting surface. A first electrode electrically is connected with the first semiconductor layer. A second electrode is electrically connected with the second semiconductor layer. A number of first three-dimensional nano-structures are located on the surface of the first surface of the first semiconductor layer. A number of second three-dimensional nano-structures are located on the substrate, and a cross section of each of the three-dimensional nano-structures is M-shaped.
US08946749B2 Semiconductor light emitting device
A semiconductor light emitting device includes a substrate having a wiring pattern formed thereon, and a semiconductor light emitting element mounted on one main surface of the substrate and electrically connected to the wiring pattern. The substrate has, on the one main surface, a serrated structure reflecting at least part of light emitted from said semiconductor light emitting element to the substrate, to a direction perpendicular to the one main surface.
US08946743B2 Light emitting apparatus
Disclosed is a light emitting apparatus. The light emitting apparatus includes a package body; first and second electrodes; a light emitting device electrically connected to the first and second electrodes and including a first conductive semiconductor layer, a second conductive semiconductor layer, and an active layer between the first and second conductive semiconductor layers; and a lens supported on the package body and at least a part of the lens including a reflective structure. The package body includes a first cavity, one ends of the first and second electrodes are exposed in the first cavity and other ends of the first and second electrodes are exposed at lateral sides of the package body, and a second cavity is formed at a predetermined portion of the first electrode exposed in the first cavity.
US08946741B2 LED with enhanced light extraction
A light emitting device having a plurality of light extracting elements defined on an upper surface of a semiconductor layer of the device, wherein the light extracting elements are adapted to couple light out of the device and to modify the far field emission profile of the device. Each element comprises an elongate region having a length at least twice its width and also greater than the effective dominant wavelength of light generated in the device. The elongate region extends orthogonal to the upper surface but not into the light emitting region of the device and may be oriented at an angle of less than 45° relative to one of a pair of basis axis defining a plane parallel to the semiconductor layer. Each elongate region is spatially separated from neighboring elongate regions such that it perturbs light generated in the light emitting region independently of the neighboring regions.
US08946740B2 LED platform with membrane
An LED package comprises: an LED chip having an optically active layer on a substrate, a platform, including a central membrane of which the LED chip is mounted in close thermal contact to the material of the platform, the thickness of the membrane being less than 3/10 the chip dimension (L) the thickness of the supporting frame being more than twice the membrane thickness, typically 10 times and possibility up to 25 times which is integrally formed with the membrane, is substantially larger than the thickness of the membrane, wherein the membrane is provided with at least an electrically isolated through contact filled with electrically conducting material and connected to one of the electrodes of the LED chip.
US08946739B2 Process to fabricate integrated MWIR emitter
A device for medium wavelength infrared emission and a method for the manufacture thereof is provided. The device has a semiconductor substrate; a passive hermetic barrier disposed upon the substrate, and an emitter element disposed within said hermetic barrier; and a mirror.
US08946737B2 Light emitting diode and manufacturing method thereof
A light emitting diode (LED) includes a substrate, a buffer layer and an epitaxial structure. The substrate has a first surface with a patterning structure formed thereon. The patterning structure includes a plurality of projections. The buffer layer is arranged on the first surface of the substrate. The epitaxial structure is arranged on the buffer layer. The epitaxial structure includes a first semiconductor layer, an active layer and a second semiconductor layer arranged on the buffer layer in sequence. The first semiconductor layer has a second surface attached to the active layer. A distance between a peak of each the projections and the second surface of the first semiconductor layer is ranged from 0.5 μm to 2.5 μm.
US08946736B2 Optoelectronic device and method for manufacturing the same
An optoelectronic device comprising, a substrate and a first transition stack formed on the substrate comprising a first transition layer formed on the substrate having a hollow component formed inside the first transition layer, a second transition layer formed on the first transition layer, and a reflector rod formed inside the second transition layer.
US08946733B2 Organic light-emitting display apparatus having a light-scattering face and method of manufacturing the same
An organic light-emitting display apparatus that improves image quality characteristics, the organic light-emitting display apparatus including: a substrate; a first electrode formed on the substrate; a pixel-defining layer (PDL) formed on the first electrode to expose a set or predetermined region of the first electrode; an intermediate layer formed in the exposed predetermined region of the first electrode and including an organic emission layer; and a second electrode having a light-scattering face facing the substrate or facing oppositely away from the substrate, the second electrode being disposed on the intermediate layer.
US08946732B2 Touch panel having photo-sensors and read-out transistors and fabricating method thereof
A touch panel and fabricating method thereof are provided. The patterned transparent conductive layer, disposed on the substrate, includes first electrodes. The photo-sensing layers are disposed on the first electrodes. The first patterned conductive layer includes gate electrodes, scan lines and second electrodes. The gate electrodes and the scan lines are disposed on the substrate. The second electrodes are disposed on the photo-sensing layers. The first electrodes, the photo-sensing layers and the second electrodes constitute photo-sensors. The second patterned conductive layer includes source electrodes and drain electrodes, wherein the gate electrodes, the channel layers, the source electrodes and the drain electrodes constitute read-out transistors and each of the read-out transistors is electrically connected to the corresponding photo-sensor respectively.
US08946719B2 TFT, shift register, scan signal line driving circuit, display device, and TFT trimming method
In at least one embodiment, a TFT includes: a first capacitor formed of a first capacitor electrode connected to a source electrode and a second capacitor electrode; a second capacitor formed of a third capacitor electrode and a fourth capacitor electrode; a first lead-out line; a second lead-out line connected to a gate electrode; a third lead-out line; a fourth lead-out line; a first interconnection; and a second interconnection. This realizes a TFT which can be easily saved from being a defective product even if leakage occurs in a capacitor connected to a TFT body section.
US08946717B2 Semiconductor element and display device using the same
A semiconductor having an active layer; a gate insulating film in contact with the semiconductor; a gate electrode opposite to the active layer through the gate insulating film; a first nitride insulating film formed over the active layer; a photosensitive organic resin film formed on the first nitride insulating film; a second nitride insulating film formed on the photosensitive organic resin film; and a wiring provided on the second, nitride insulating film. A first opening portion is provided in the photosensitive organic resin film, an inner wall surface of the first opening portion is covered with the second nitride insulating film, a second opening portion is provided in a laminate including the gate insulating film, the first nitride insulating film, and the second nitride insulating film inside the first opening portion, and the semiconductor is connected with the wiring through the first opening portion and the second opening portion.
US08946713B2 Electrostatic discharge protection structure for an active array substrate
Disclosed herein is an electrostatic discharge protection structure which includes a signal line, a thin-film transistor and a shunt wire. The thin-film transistor includes a gate electrode, a metal-oxide semiconductor layer, a source electrode and a drain electrode. The first metal-oxide semiconductor layer is disposed above the first gate electrode. The metal-oxide semiconductor layer has a channel region characterized in having a width/length ratio of less than 1. The source electrode is equipotentially connected to the gate electrode. The shunt wire is electrically connected to the drain electrode. When the signal line receives a voltage surge of greater than a predetermined magnitude, the voltage surge is shunted through the thin-film transistor to the shunt wire.
US08946711B2 Organic light-emitting display device including black matrix-containing neutral density film
An organic light-emitting display device including: a substrate; a plurality of pixels each including a first electrode, a second electrode, and an organic emission layer interposed between the first electrode and the second electrode; and a black matrix-containing neutral density (ND) film formed in a direction in which light is emitted from the plurality of pixels.
US08946709B2 Semiconductor device
A semiconductor device with a novel structure is provided in which stored data can be held even when power is not supplied and the number of writing is not limited. The semiconductor includes a second transistor and a capacitor over a first transistor. The capacitor includes a source or drain electrode and a gate insulating layer of the second transistor and a capacitor electrode over an insulating layer which covers the second transistor. The gate electrode of the second transistor and the capacitor electrode overlap at least partly with each other with the insulating layer interposed therebetween. By forming the gate electrode of the second transistor and the capacitor electrode using different layers, an integration degree of the semiconductor device can be improved.
US08946704B2 Semiconductor device
A semiconductor device in which release of oxygen from side surfaces of an oxide semiconductor film including c-axis aligned crystal parts can be prevented is provided. The semiconductor device includes a first oxide semiconductor film, a second oxide semiconductor film including c-axis aligned crystal parts, and an oxide film including c-axis aligned crystal parts. In the semiconductor device, the first oxide semiconductor film, the second oxide semiconductor film, and the oxide film are each formed using a IGZO film, where the second oxide semiconductor film has a higher indium content than the first oxide semiconductor film, the first oxide semiconductor film has a higher indium content than the oxide film, the oxide film has a higher gallium content than the first oxide semiconductor film, and the first oxide semiconductor film has a higher gallium content than the second oxide semiconductor film.
US08946703B2 Method for manufacturing semiconductor device
To provide a method by which a semiconductor device including a thin film transistor with excellent electric characteristics and high reliability is manufactured with a small number of steps. After a channel protective layer is formed over an oxide semiconductor film containing In, Ga, and Zn, a film having n-type conductivity and a conductive film are formed, and a resist mask is formed over the conductive film. The conductive film, the film having n-type conductivity, and the oxide semiconductor film containing In, Ga, and Zn are etched using the channel protective layer and gate insulating films as etching stoppers with the resist mask, so that source and drain electrode layers, a buffer layer, and a semiconductor layer are formed.
US08946697B1 Iridium complexes with aza-benzo fused ligands
Novel iridium complexes containing phenylpyridine and pyridyl aza-benzo fused ligands are described. Iridium complexes containing aza-benzo fused ligands in which an aryl group is conjugated to the aza ring of the specific aza-dibenzofuran ring system results in the formation of yellow phosphorescent compounds with superior device stability and efficiency. These complexes are useful as light emitters when incorporated into OLEDs.
US08946695B2 Compound, and organic light-emitting device using same
The present invention provides a new compound which may significantly improve the service life, efficiency, electrochemical stability, and thermal stability of an organic light emitting device, and an organic light emitting device which comprises an organic material layer comprising the compound.
US08946692B2 Graphene (multilayer) boron nitride heteroepitaxy for electronic device applications
Disclosed is a substrate-mediated assembly for graphene structures. According to an embodiment, long-range ordered, multilayer BN(111) films can be formed by atomic layer deposition (ALD) onto a substrate. The subject BN(111) films can then be used to order carbon atoms into a graphene sheet during a carbon deposition process.
US08946688B2 Polycyclic ring-fused compound and organic thin film transistor utilizing the same
A compound for an organic thin film transistor represented by the following formula (1):
US08946684B2 Light-emitting device, illumination apparatus, and display apparatus
A light-emitting device includes: an organic layer which is interposed between a first electrode and a second electrode and in which a first light-emitting layer and a second light-emitting layer emitting light of single colors or two or more different colors in a visible wavelength region are sequentially included at mutually separated positions in that order in a direction from the first electrode to the second electrode; a first reflective interface which is provided on the side of the first electrode so as to reflect light emitted from the first light-emitting layer and the second light-emitting layer to be emitted from the side of the second electrode; and a second reflective interface and a third reflective interface which are sequentially provided on the side of the second electrode at mutually separated positions in that order in a direction from the first electrode to the second electrode.
US08946679B2 Vertical tunneling negative differential resistance devices
The present disclosure relates to the fabrication of microelectronic devices having at least one negative differential resistance device formed therein. In at least one embodiment, the negative differential resistance devices may be formed utilizing quantum wells. Embodiments of negative differential resistance devices of present description may achieve high peak drive current to enable high performance and a high peak-to-valley current ratio to enable low power dissipation and noise margins, which allows for their use in logic and/or memory integrated circuitry.
US08946678B2 Room temperature nanowire IR, visible and UV photodetectors
Room temperature IR and UV photodetectors are provided by electrochemical self-assembly of nanowires. The detectivity of such IR detectors is up to ten times better than the state of the art. Broad peaks are observed in the room temperature absorption spectra of 10-nm diameter nanowires of CdSe and ZnS at photon energies close to the bandgap energy, indicating that the detectors are frequency selective and preferably detect light of specific frequencies. Provided is a photodetector comprising: an aluminum substrate; a layer of insulator disposed on the aluminum substrate and comprising an array of columnar pores; a plurality of semiconductor nanowires disposed within the pores and standing vertically relative to the aluminum substrate; a layer of nickel disposed in operable communication with one or more of the semiconductor nanowires; and wire leads in operable communication with the aluminum substrate and the layer of nickel for connection with an electrical circuit.
US08946675B2 Light emitting diode and method for manufacturing the same
A light emitting diode includes a substrate, a first-type semiconductor layer, a nanorod layer and a transparent planar layer. The first-type semiconductor layer is disposed over the substrate. The nanorod layer is formed on the first-type semiconductor layer. The nanorod layer includes a plurality of nanorods and each of the nanorods has a quantum well structure and a second-type semiconductor layer. The quantum well structure is in contact with the first-type semiconductor layer, and the second-type semiconductor layer is formed on the quantum well structure. The transparent planar layer is filled between the nanorods. A surface of the second-type semiconductor layer is exposed out of the transparent planar layer.
US08946673B1 Resistive switching device structure with improved data retention for non-volatile memory device and method
A non-volatile memory device structure includes a first conductor extending in a first direction, a second conductor extending in a second direction approximately orthogonal to the first direction, an amorphous silicon material disposed in an intersection between the first and second conductors characterized by a first resistance upon application of a first voltage, wherein the first resistance is dependent on a conductor structure comprising material from the second conductor formed in a portion of the resistive switching material, and a layer of material configured in between the second conductor and the amorphous silicon material, wherein the layer maintains at least a portion the conductor structure in the amorphous silicon material, and wherein the layer inhibits conductor species from the portion of the conductor structure from migrating away from the second conductor when a second voltage having an amplitude less than the first voltage is applied.
US08946672B2 Resistance changing element capable of operating at low voltage, semiconductor device, and method for forming resistance change element
A resistance changing element according to the present invention comprises a first electrode (101) and a second electrode (103); and an ion conducting layer (102) that is formed between the first electrode (101) and the second electrode (103) and that contains at least oxygen and carbon.
US08946666B2 Ge-Rich GST-212 phase change memory materials
A phase change material comprises GexSbyTez, wherein a Ge atomic concentration x is within a range from 30% to 65%, a Sb atomic concentration y is within a range from 13% to 27% and a Te atomic concentration z is within a range from 20% to 45%. A Ge-rich family of such materials is also described. A memory device, suitable for integrated circuits, comprising such materials is described.
US08946665B2 Semiconductor devices and methods of fabricating the same
A semiconductor device includes a plurality of first insulating layers and a plurality of second layers alternately and vertically stacked on a substrate. Each of the plurality of second layers includes a horizontal electrode horizontally separated by a second insulating layer. A contact plug penetrates the plurality of first insulating layers and the second insulating layer of the plurality of second layers.
US08946664B2 Optical sensor device having wiring pattern within cavity housing optical sensor element
A low-cost, compact, high-reliability optical sensor device has an optical sensor element mounted in a package comprised of a light shielding glass lid substrate, a part of which has a light filter function, adhered to a light shielding glass substrate having a cavity. In a through hole in the light shielding glass lid substrate, glass having a function of absorbing infrared light and transmitting visible light by its own property is embedded. The light shielding glass substrate is made of glass having light shielding property as its own property.
US08946660B2 Downhole sources having enhanced IR emission
Light sources are provided with enhanced low-frequency (e.g., near infrared) emission. Some disclosed embodiments include a filament and at least one re-radiator element. The filament heats the re-radiator element to a steady-state temperature that is at least one quarter of the filament's absolute temperature. As disclosed herein, the increased surface area provided by the re-radiator element provides enhanced IR radiation from the light source. Patterning or texturing of the surface can further increase the re-radiator element's surface area. Various shapes such as disks, collars, tubes are illustrated and can be combined to customize the spectral emission profile of the light source. Some specific embodiments employ a coating on the bulb as the re-radiator element. The coating can be positioned to occlude light from the filament or to augment light from the filament, depending on the particular application. The various re-radiator elements can be positioned inside or outside the bulb.
US08946658B2 Device for disturbing the operation of an integrated circuit
A system for injecting faults by laser beams into an electronic circuit including: at least two lasers capable of emitting approximately parallel beams; at least one optical system receiving, on the magnifying side, the beams; and a support of the integrated circuit placed on the reducing side of the optical system.
US08946655B2 Multiphoton luminescence imaging of protein crystals
A method for detecting protein crystals comprises: illuminating a sample with a laser to produce multiphoton excitation; collecting an emission spectrum; and determining whether the sample comprises protein crystals.
US08946643B2 Virtual pixelated detector for pet and/or spect
A slab detector for PET and/or SPECT imaging comprising a scintillation crystal slab and a plurality of photoconverters each in optical communication with a surface of the scintillation crystal. In some embodiments, the plurality of photoconverters define a two dimensional array, wherein each photoconverter abuts adjacent photoconverters. Furthermore, according to some embodiments a plurality of slab detectors can be juxtaposed with one another so that their slab crystals abut edgewise.
US08946639B2 Compensated optical detection apparatus, systems, and methods
In some embodiments, apparatus and systems, as well as methods, may operate to receive radiation at an active detector of a pair of radiation detectors to provide a first signal proportional to an intensity of the radiation, to receive none of the radiation at a blind detector of the pair of radiation detectors to provide a second signal proportional to the reception of no radiation, and to combine the first signal and the second signal to provide an output signal representing the difference between the first signal and the second signal. The pair of radiation detectors may comprise thermopile detectors. Combination may occur via differential amplification. Additional apparatus, systems, and methods are disclosed.
US08946637B2 Compact fiber-based scanning laser detection and ranging system
A system for short-range laser detection and ranging of targets can provides rapid three-dimensional, e.g., angle, angle, range, scans over a wide field-of-view. Except for the final transmit/receive lens, the disclosed LADAR system can be implemented in an all-fiber configuration. Such system is compact, low cost, robust to misalignment, and lends itself to eye-safe operation by making use of available pulsed 1550 nm fiber lasers and amplifier sources. The disclosed LADAR system incorporates many novel features that provide significant advantages compared to current LADAR systems. The disclosed system uses a monostatic fiber-based transmitter/receiver, a fiber beam scanner based on a laterally vibrating fiber, and a position sensor to monitor the transmitted beam position.
US08946635B2 System and method for measuring radiant energy in gas turbine engines, components and rigs
One embodiment of the present invention is a unique system for measuring radiant energy in gas turbine engines, gas turbine engine components and gas turbine engine/component rigs. Another embodiment is a unique method for measuring radiant energy in gas turbine engines, gas turbine engine components and gas turbine engine/component rigs. Other embodiments include apparatuses, systems, devices, hardware, methods, and combinations for measuring radiant energy. Further embodiments, forms, features, aspects, benefits, and advantages of the present application shall become apparent from the description and figures provided herewith.
US08946632B2 System and method for terahertz 2D interferometric and synthetic aperture imaging with an incoherent source
An interferometric and synthetic aperture THz incoherent imaging system is provided, in which a high-power electronic source such as a 0.094 THz Gunn Oscillator is integrated with a continuous-wave (CW) terahertz detection system in order to achieve a high signal-to-noise ratio. THz imaging of a point source located 10 m away from the detector array is presented. A 2-D THz reflective image is reconstructed with only four detectors using rotational synthesis.
US08946627B2 Three-dimensional mapping using scanning electron microscope images
A method includes irradiating a surface of a sample, which is made-up of multiple types of materials, with a beam of primary electrons. Emitted electrons emitted from the irradiated sample are detected using multiple detectors that are positioned at respective different positions relative to the sample, so as to produce respective detector outputs. Calibration factors are computed to compensate for variations in emitted electron yield among the types of the materials, by identifying, for each material type, one or more horizontal regions on the surface that are made-up of the material type, and computing a calibration factor for the material type based on at least one of the detector outputs at the identified horizontal regions. The calibration factors are applied to the detector outputs. A three-dimensional topographical model of the surface is calculated based on the detector outputs to which the calibration factors are applied.
US08946625B2 Introduction of ions into a magnetic field
In a mass spectrometer that uses a space-restricted magnetic field, such as an ion cyclotron resonance mass spectrometer, ions with a wide mass range generated in an ion supply located outside the magnetic field are transported in the direction of the magnetic field lines to an ion storage device located inside the magnetic field without losing ions by guiding the ions through the region in which the magnetic field strength increases with a special ion guide. This ion guide consists of an arrangement of coaxial ring diaphragms which are alternately supplied with the phases of an RF voltage. In an alternative embodiment, the ion guide uses two wires wound in a double helix where each wire is supplied with one phase of a two-phase RF voltage.
US08946624B2 Mass spectrometer having an external detector
A mass spectrometer system is disclosed. The mass spectrometer includes a vacuum chamber defining an enclosed evacuated space and an ion trap disposed in the enclosed space. The ion trap is configured to trap an ionized sample. The mass spectrometer further includes an ion detector coupled to the chamber at a location external to the chamber such that sample ions may exit the evacuated space and into the externally-coupled detector without loss of vacuum pressure.
US08946623B2 Introduction of ions into kingdon ion traps
The geometry of a Kingdon ion trap, in which harmonic ion oscillation in a potential well in a longitudinal direction is completely decoupled from ion oscillation in a direction transverse to the longitudinal direction, is arranged so that the oscillating ions introduced through the entrance tube cannot return to the entrance tube until they have performed several longitudinal oscillations during which time heavier ions can be introduced into the trap. In one embodiment, ions enter the trap via an entrance tube extending through, but electrically insulated from, one of the Kingdon trap housing electrodes and located outside the minimum of the potential well in the longitudinal direction.
US08946622B2 Mass spectrometer interface
A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.
US08946619B2 Talbot-illuminated imaging devices, systems, and methods for focal plane tuning
A Talbot-illuminated imaging system for focal plane tuning, the device comprising a Talbot element, a tunable illumination source, a scanning mechanism, a light detector, and a processor. The element generate san array of focused light spots at a focal plane. The tunable illumination source shifts the focal plane to a plane of interest by adjusting a wavelength of light incident the Talbot element. The scanning mechanism scans an object across an array of focused light spots in a scanning direction. The light detector determines time-varying light data associated with the array of focused light spots as the object scans across the array of light spots. The processor constructs an image of the object based on the time-varying data.
US08946617B2 Photodiode having a p-n junction with varying expansion of the space charge zone due to application of a variable voltage
A photodiode comprises a semiconductor material having a p-n junction, the p-n junction being located between a first doping region of a first doping type and a second doping region of a second doping type, the second doping region comprising a highly doped layer and a lightly doped layer. A photodiode further comprises a voltage source being capable to apply a variable voltage between the first doping region and the lightly doped layer of the second doping region in order to vary the expansion of a space charge zone of the p-n junction.
US08946609B2 Solid state luminaires for general illumination
A lighting panel includes a tile having a first side parallel to a principal plane of the lighting panel, a plurality of solid state lighting devices arranged on the first side of the tile and configured to emit light, a reflector sheet on the first side of the tile, and a brightness enhancement film on the reflector sheet. The reflector sheet may be arranged between the tile and the brightness enhancement film and the brightness enhancement film may be configured to increase the on-axis intensity of emitted light. A luminaire adapted for general illumination includes a lighting panel as described above, a current supply circuit configured to supply an on-state drive current to a string of lighting devices in response to a control signal, a photosensor arranged to receive light from one of the solid state lighting devices, and a control system configured to receive an output signal from the photosensor and to adjust the control signal responsive to the output signal of the photosensor.
US08946608B2 Solar tracking system
An automated method causes a terrestrial solar cell array to track the sun. The solar cell system includes motors that adjust a position of the array along different respective axes with respect to the sun, wherein a first motor adjusts the inclination angle of the array relative to the surface of the earth and a second motor rotates the array about an axis substantially perpendicular to that surface. The method includes (a) using a software algorithm to predict a position of the sun at a future time; (b) using a computer model to determine respective positions for the motors corresponding to the solar cell array being substantially aligned with the sun at the future time; and (c) activating and operating the motors at respective particular speeds so that at the future time the solar cell array is substantially aligned with the sun. The future time may correspond to any time during operation. An initial future time may correspond to a start up time after sunrise at which point the solar cell is to begin tracking the sun.
US08946607B2 Mechanisms for deploying and actuating airfoil-shaped bodies on unmanned aerial vehicles
Deployment and control actuation mechanisms are incorporated in unmanned aerial vehicles having folding wings and/or folding canards and/or a folding vertical stabilizer. The folding canards and folding vertical stabilizer can be deployed using respective four-bar over-center mechanisms. Elevators pivotably mounted to the folding canards and a rudder pivotably mounted to the folding vertical stabilizer can be controlled by means of respective twist link mechanisms. The folding wings have respective wing roots that are driven by respective gas springs to pivot on bearings about a wing root hub having control servo wire paths.
US08946600B1 Roof de-icing system
A roof de-icing system has a plurality of heating units connected in parallel to a common power source. The heating units can include one or more heating panels positioned along the lower edge of a roof, valley heating panels which extend along valleys of the roof, gutter heating panels which extend along the bottoms of gutters secured proximate a lower edge of the roof, and heating strips which extend along a roof below the drip line of a second higher roof. Each of the heating units has an indica to indicate a failure of that unit.
US08946599B2 Electric heating device
The invention under consideration relates to an electric heating device for heating a flowing medium with a housing, in which the at least one electric heating element of the electric heating device is held securely and fully shielded from the medium held in the circulation chamber by a separating wall that divides the housing into a heating chamber and a circulation chamber. The circulation chamber has inlet openings and outlet openings for introducing and removing, respectively, the medium. The heating element is preferably a PTC heating element and is held by means of a clamping force in a recess formed by the separating wall, said recess preferably projecting into the circulation chamber. The invention furthermore relates to a recuperator for converting electrical energy into thermal energy, particularly for an electric drive in a vehicle.
US08946598B2 Reticulate heater for steering wheel
A reticulate heater for a steering wheel exhibits flexibility, elasticity and waterproofness. The reticulate heater comprises a reticulate heat generating element (11) consisting of a plurality of insulated heater wires (14) braided in a mesh form, and exhibiting flexibility and elasticity to permit tight contact with a curved surface, a waterproof stretch-film (12) covering the front and rear surfaces of the reticulate heat generating element (11) water-tightly and adhering to the reticulate heat generating element (11) while still keeping the flexibility and elasticity thereof, and an elastic adhesive (13) having flexibility and elasticity even after curing, applied to the whole surface of the stretch-film (12) on the adhering surface side in a planar and thin state, and bonding the stretch-film (12) to the reticulate heat generating element (11) water-tightly even if the stretch-film (12) is stretched within an allowable tensile range.
US08946595B2 Apparatus and method for determining shape of end of welding bead
An apparatus 1 of the present invention includes a laser emitting unit 2, a monitor unit 3, a storage unit 4, an image extraction unit 5, a bead recognition unit 6, and a bead shape determination unit 7. The bead shape determination unit 7 is configured to calculate the position of the end of a bead region based on the bead region recognized by the bead recognition unit 6, and to determine whether the shape of the end of the bead region is convex or concave in the extending direction of the bead region.
US08946594B2 Optical design for line generation using microlens array
Embodiments of the invention provide an apparatus including a substrate support, a source of laser radiation emitting laser radiation along an optical path, and an illumination optics disposed along the optical path. The illumination optics includes a set of slow-axis and fast-axis lenses. The apparatus further includes a homogenizer disposed between of the illumination optics and the substrate support along the optical path. The homogenizer includes a first and a second micro-optic lenslet arrays of cylindrical lenses, wherein the second micro-optic lenslet array of cylindrical lenses has a relatively larger lenslet pitch than that of the first micro-optic lenslet array of cylindrical lenses, and lenslet axes of the first micro-optic lenslet array and lenslet axes of the second micro-optic lenslet array are oriented along an axis that is parallel to a fast axis of the source of laser radiation.
US08946589B2 Method of cutting a substrate, method of cutting a wafer-like object, and method of manufacturing a semiconductor device
A laser beam machining method and a laser beam machining device capable of cutting a work without producing a fusing and a cracking out of a predetermined cutting line on the surface of the work, wherein a pulse laser beam is radiated on the predetermined cut line on the surface of the work under the conditions causing a multiple photon absorption and with a condensed point aligned to the inside of the work, and a modified area is formed inside the work along the predetermined determined cut line by moving the condensed point along the predetermined cut line, whereby the work can be cut with a rather small force by cracking the work along the predetermined cut line starting from the modified area and, because the pulse laser beam radiated is not almost absorbed onto the surface of the work, the surface is not fused even if the modified area is formed.
US08946582B1 System and method for metal powder welding
A system and method for submerged arc metal powder welds includes modular programmable control of: a) a weld torch, and the position of the welding wire(s) from the torch traveling within a weld cavity, b) the rate of metal powder and welding flux added to the weld cavity ahead of the weld torch, c) the matching ratio between of metal powder and welding wire within the weld cavity, and d) a square wave welding torch power supply. An embodiment includes a controlled column and boom manipulator with up to six axes of motion and controlled motorized slide assemblies for single or multi-pass welds. A method of use is also disclosed.
US08946579B2 Touch panel
A touch panel includes an upper substrate having insulating property, an upper conductive layer on a lower surface of the upper substrate, an intermediate layer on a lower surface of the upper conductive layer, an upper electrode on a lower surface of the intermediate layer, a lower conductive layer facing the upper conductive layer with a predetermined gap interposed between the conductive layers, a lower electrode on an upper surface of the lower conductive layer, and a lower substrate on a lower surface of the lower conductive layer and having insulating property. The upper and lower electrodes contain 70 wt. % to 98 wt. % of conductive metal. The intermediate layer contains a resin and 40 wt. % to 90 wt. % of carbon and has a thickness ranging from 1 μm to 50 μm. The touch panel has resistance to environment and is applicable to a large size.
US08946570B2 Keyboard systems utilizing a switch and proximity sensors
A keyboard apparatus is provided. The apparatus can include a rigid member comprising a plurality of keycaps and a proximity sensing member comprising a plurality of proximity sensors and a plurality of illuminators disposed proximate the rigid keycap member. The apparatus can also include a backing member comprising a switch disposed proximate the proximity sensing member. A displacement of the rigid member and the proximity sensing member can activate the switch.
US08946567B2 Power module, power converter device, and electrically powered vehicle
A power module and a power converter device including the power module include: two base plates with their main surfaces facing each other; a semiconductor circuit unit disposed between the two base plates; a connecting member that is connected to the two base plates and forms a housing region in which the semiconductor circuit unit is housed; and an insulating member that is placed between the base plate and the semiconductor circuit unit and secures electrical insulation of the base plate and the semiconductor circuit unit. A rigidity or thickness of the connecting member is less than a rigidity or thickness of the base plate.
US08946564B2 Packaging substrate having embedded through-via interposer and method of fabricating the same
A packaging substrate having an embedded through-via interposer is provided, including an encapsulant layer, a through-via interposer embedded in the encapsulant layer and having a plurality of conductive through-vias therein, a redistribution layer embedded in the encapsulant layer and formed on the through-via interposer so as to electrically connect with first end surfaces of the conductive through-vias, and a built-up structure formed on the encapsulant layer and the through-via interposer for electrically connecting second end surfaces of the conductive through-vias. As such, the first end surfaces of the conductive through-vias are electrically connected to the redistribution layer to thereby be electrically connected to electrode pads of a semiconductor chip having smaller pitches, while the second end surfaces of the conductive through-vias electrically connect with conductive vias of the built-up structure having larger pitches, thereby allowing the packaging substrate to be coupled with the semiconductor chip.
US08946563B2 Module with exposed parts of copper foil and process for production thereof
A module including a circuit board including an insulating layer and one or more layers of copper foil embedded in the insulating layer; an electronic component mounted on the circuit board; a sealing part sealing the electronic component on the circuit board; and a metal film covering side surfaces of the circuit board and surfaces of the sealing part. A part of the copper foil is exposed to the side surfaces of the circuit board, an exposed part of the copper foil has a width of less than 200 μm, and the copper foil and the metal film are electrically coupled to each other through the exposed part. Thus, occurrence of blushing, crack, or the like, can be prevented.
US08946554B1 Cable-end water sealing device for water-blocking non-water-blocked cable
A cable-end water sealing device includes a water-blocking compound, a receptacle and a sleeve. The receptacle defines an interior cavity for receiving an end portion of a non-water-blocked electrical, optical, or electrical/optical (i.e., hybrid) cable. The receptacle includes a stop member for limiting the insertion depth of the cable, an adjoining interior cavity for receiving and transitioning the cable subcomponents and one or more optional overall EMI shield(s) to the outside of the receptacle, and an injection port for injecting the water-blocking compound into both interior cavities of the receptacle to prevent water from migrating from the end of the cable. One or more of the cable subcomponents may include one or more individual EMI shields. Individual insulating sleeves can be provided to electrically isolate the cable subcomponent EMI shield(s) from the receptacle and overall EMI shield(s). A heat recoverable sleeve can be provided for enclosing the receptacle and overall EMI shield(s) after injection of the water-blocking compound.
US08946552B2 High voltage direct current cable termination apparatus
A direct current cable termination apparatus for terminating a high voltage direct current cable, the apparatus includes a current-carrying device comprising a terminal portion of the direct current cable, the cable includes an electrical conductor, a circumferential electrically insulating layer located outside of the electrical conductor, and a circumferential conductive shield located outside of the insulating layer and the electrical conductor. The apparatus includes a housing having an outer shell, and the current-carrying device is adapted to extend in the axial direction of the outer shell. Along at least a part of the axial extension of the current-carrying device the outer shell extends axially with a space between its inner periphery and the current-carrying device.
US08946551B2 Floor wire harness package assembly and installation methods
A method of installing a wire harness on a floor of a vehicle body includes providing a package assembly including a sheet having a first portion and a second portion and providing a wire harness including a plurality of insulated electrical wires connected to a plurality of electrical connectors. The wire harness is positioned on the sheet. The first portion is displaced toward the second portion to provide a wire harness package assembly. The wire harness package assembly is positioned on the floor of the vehicle body. The first portion is displaced away from the second portion on the floor of the vehicle. Each of the plurality of electrical connectors are connected to one of a plurality of in-vehicle electrical connectors.
US08946550B1 Electrical device cover
An electrical device cover configured for mounting over an electrical device comprises a frame including a frame channel and an frame opening. The frame opening is defined by at least four sides and is large enough to receive at least one electrical device. A sliding tab comprising a screw channel is provided, the sliding tab is slidably coupled with the frame channel and is slideable to a closed position in which the screw channel at least partially surrounds a box mounting screw of the at least one electrical device.
US08946549B2 Metal sheathed cable assembly
A Metal-Clad cable that includes at least two conductor assemblies within a metal armored sheath. Each conductor assembly has an electrical conductor, an insulation layer extending around and along the length of each of the electrical conductors, a jacket layer disposed around the insulating layer and a polymeric protective layer disposed around the jacket layer along the length of each of the electrical conductors. A grounding/bonding strip is disposed within the cable and is in intimate contact with an interior surface of the metal sheath. If a grounding conductor is used, it is either in cabled relationship with the two conductor assemblies or is disposed along the length of the electrical conductors and the metal sheath is disposed over the at least two conductor assemblies and the grounding conductor.
US08946546B2 Surface treatment of nanocrystal quantum dots after film deposition
Provided are methods of surface treatment of nanocrystal quantum dots after film deposition so as to exchange the native ligands of the quantum dots for exchange ligands that result in improvement in charge extraction from the nanocrystals.
US08946535B2 Split keyboard for PC data and music output
A split keyboard with an optional middle section of keys for controlling regular PC input to a host, to play music, and to input and play music with a multiple octave keyboard that when the middle section of keys are removed can be portable to travel. And when working on just the split keyboard inputting data to a host the operator arms are not abducted due to the perpendicular advantage or slide apart keyboard where an operators arms are perpendicular to the keyboard keys.
US08946531B2 Spring force adjustment structure in high-hat stand and high-hat stand including the spring force adjustment structure
To provide a spring force adjustment structure in a high-hat stand that allows a user to easily adjust a spring force with one hand without reducing a floor space, easily understand the amounts of adjustments made, easily estimate the amount of adjustment to be made when making a fine-tuning afterward, and easily return the spring force to the state before the adjustment.
US08946529B2 Top mounted tremolo and tuning apparatus
A tremolo and tuning apparatus is provided for a stringed musical instrument. The apparatus includes a mounting frame configured for mounting on the surface of the body of the instrument, an attachment post secured to the body, a base plate pivotally mounted with respect to the attachment post and having a surface adapted to receive a force, a mounting assembly mounted on the base plate for holding a string of the instrument, and a first resilient member assembly for engagement with the mounting frame outside the body of the instrument and supplying a stabilizing force to the base plate against a tension force in the string. The apparatus includes a second resilient member assembly configured to be engaged with the mounting frame outside the body of the instrument and to supply a force to the base plate surface adapted to receive the force.
US08946526B2 Plants and seeds of hybrid corn variety CH612435
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH612435. The invention thus relates to the plants, seeds and tissue cultures of the variety CH612435, and to methods for producing a corn plant produced by crossing a corn plant of variety CH612435 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH612435.
US08946525B2 Plants and seeds of hybrid corn variety CH164731
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH164731. The invention thus relates to the plants, seeds and tissue cultures of the variety CH164731, and to methods for producing a corn plant produced by crossing a corn plant of variety CH164731 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH164731.
US08946522B1 Soybean variety XBP20002
A novel soybean variety, designated XBP20002 is provided. Also provided are the seeds of soybean variety XBP20002, cells from soybean variety XBP20002, plants of soybean XBP20002, and plant parts of soybean variety XBP20002. Methods provided include producing a soybean plant by crossing soybean variety XBP20002 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XBP20002, methods for producing other soybean varieties or plant parts derived from soybean variety XBP20002, and methods of characterizing soybean variety XBP20002. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XBP20002 are further provided.
US08946521B2 Soybean variety XB33F13
A novel soybean variety, designated XB33F13 is provided. Also provided are the seeds of soybean variety XB33F13, cells from soybean variety XB33F13, plants of soybean XB33F13, and plant parts of soybean variety XB33F13. Methods provided include producing a soybean plant by crossing soybean variety XB33F13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB33F13, methods for producing other soybean varieties or plant parts derived from soybean variety XB33F13, and methods of characterizing soybean variety XB33F13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB33F13 are further provided.
US08946518B2 Soybean variety XB05B13
A novel soybean variety, designated XB05B13 is provided. Also provided are the seeds of soybean variety XB05B13, cells from soybean variety XB05B13, plants of soybean XB05B13, and plant parts of soybean variety XB05B13. Methods provided include producing a soybean plant by crossing soybean variety XB05B13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB05B13, methods for producing other soybean varieties or plant parts derived from soybean variety XB05B13, and methods of characterizing soybean variety XB05B13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB05B13 are further provided.
US08946514B2 Sorghum fertility restorer genotypes and methods of marker-assisted selection
Markers tightly associated with a sorghum (Sorghum bicolor) cms fertility restorer gene are identified, as well as genes containing the pentatrico peptide repeat (PPR) motif. Methods for marker assisted selection of restorer and non-restorer sorghum lines are provided. The markers can be used to facilitate development of the maintainer, restorer and cms sorghum lines used to make hybrids.
US08946510B2 Compositions and methods for control of insect infestations in plants
The present invention is directed to controlling pest infestation by inhibiting one or more biological functions in an invertebrate pest. The invention discloses methods and compositions for use in controlling pest infestation by feeding one or more different recombinant double stranded RNA molecules to the pest in order to achieve a reduction in pest infestation through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.
US08946509B1 Maize hybrid X80C992
A novel maize variety designated X80C992 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X80C992 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X80C992 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X80C992, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X80C992. This invention further relates to methods for producing maize varieties derived from maize variety X80C992.
US08946507B2 Method of selectively producing male or female sterile plants
A method of producing male or female sterile plants comprising the steps of transforming plant material with a polynucleotide which encodes at least one enzyme which reacts with a non-phytotoxic substance to produce a phytotoxic one, and regenerating the thus transformed material into a plant, wherein the said non-phytotoxic substance is applied to the plant up to the time of male or female gamete formation and/or maturation, so that the non-phytotoxic substance provides for the production of a phytotoxic one which selectively prevents the formation of or otherwise renders the said gametes non-functional, wherein the enzyme is expressed preferentially in either male or female reproductive structures, characterised in that (i) the non-phytotoxic substance is D-phosphinothricin and (ii) the enzyme is a D-amino acid oxidase.
US08946506B2 Plants having tomato torrado virus resistance
The present invention relates to a tomato plant having within its genome at least one allele of a gene that confers resistance to Tomato torrado virus (ToTV), said virus having been deposited with the Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH on 24 Nov. 2004 under depositors reference number ToTV-E01 (DSM 16999).
US08946504B2 Promoter-regulated differentiation-dependent self-deleting cassette
Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal.
US08946502B2 Slight-incontinence sanitary napkin structure
A sanitary napkin structure, particularly for a slight incontinence, said sanitary napkin structure comprising a first substantially permeable sheet, a second substantially impermeable sheet and an absorbing pad enclosed between said first and second sheets, characterized in that said absorbing pad comprises an absorbing pad layer including a flexible cotton fiber and a superabsorbing polymer matrix, wherein the cotton fibers in said matrix have a random orientation along three axes and do not have a preferential orientation in a X-Y plane.
US08946497B1 UZM-39 aluminosilicate zeolite
A new family of coherently grown composites of TUN and IMF zeotypes have been synthesized. These zeolites are represented by the empirical formula. NanMmk+TtAl1-xExSiyOz where “n” is the mole ratio of Na to (Al+E), M represents a metal or metals from zinc, Group 1, Group 2, Group 3 and or the lanthanide series of the periodic table, “m” is the mole ratio of M to (Al+E), “k” is the average charge of the metal or metals M, T is the organic structure directing agent or agents, and E is a framework element such as gallium. These zeolites are similar to TNU-9 and IM-5 but are characterized by unique compositions and synthesis procedures and have catalytic properties for carrying out various hydrocarbon conversion processes and separation properties for carrying out various separations.
US08946492B2 Isoxazoline-substituted benzamide compound and pesticide
A substituted alkenylbenzene compound of formula (4): wherein X1 is selected from the group consisting of a halogen atom, —SF5, C1-C6haloalkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6haloalkoxy, C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl and C1-C6haloalkylsulfonyl; X3 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy and C1-C6alkylthio; X4 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, C1-C4alkyl, C1-C4alkoxy and C1-C4haloalkoxy; R3 is —C(R3a)(R3b)R3c, where R3a and R3b independently of each other are a halogen atom, or R3a and R3b together form 3- to 6-membered ring together with the carbon atom bonding them by forming a C2-C5haloalkylene chain, and R3c is selected from the group consisting of a hydrogen atom, halogen atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy and C1-C4haloalkylthio, with a proviso that in case where X1 is a fluorine atom, chlorine atom or trifluoromethyl, and both X2 and X3 are a hydrogen atom, in case where both X1 and X2 are fluorine atom and X3 is a hydrogen atom, and in case where both X1 and X2 are trifluoromethyl and X3 is a hydrogen atom, R3c is a hydrogen atom, chlorine atom, bromine atom, iodine atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio.
US08946489B2 Processing biomass
Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy or sugary materials, to produce ethanol and/or butanol, e.g., by fermentation.
US08946486B2 Method of forming alkoxylated fluoroalcohols
A method of forming an alkoxylated fluoroalcohol is accomplished by providing a boron compound having or providing at least one boron-oxygen bond and an iodine source. The boron compound and iodine source are combined with reactants of a fluoroalcohol and an alkylene oxide in the presence of a base. The reactants are allowed to react to form an alkoxylated fluoroalcohol reaction product.
US08946485B2 Branched poly(trimethylene ether) polyols
Disclosed is branched poly(trimethylene ether) polyols prepared from the acid catalyzed polycondensation reaction of 1,3-propanediol, and at least one triol comonomer selected from 1,1,1-tris(hydroxymethyl)ethane and 1,1,1-tris(hydroxymethyl)propane. Also disclosed is a branched poly(trimethylene ether) polyol with an equivalent hydroxyl functionality of about 2.1 to about 3.2 and a Mn of about 200 to about 6000. The polyols are useful in the preparation of polyurethane rigid and flexible foams.
US08946479B2 Process for preparation of 4-fluoro-α-[2methyl-l-oxopropyl]-γ-oxo—N—β-diphenylbenzene butane amide
A process for preparation of 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N-β-diphenylbenzene butane amide also known as a diketone intermediate of atorvastatin, completely devoid of impurities 3,4-difluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-n-β-diphenylbenzene butane amide; methyl, 2{-2[-(4-fluorophenyl)-2-oxo-1-phenylethyl)]}-4-methyl-3-oxo pentanoate; 1,4-bis(4-fluorophenyl)-2,3-diphenylbutane-1,4-dione, 1-(4-fluorophenyl)-2-phenyl ethanone; 1-(4-fluorophenyl)-2-phenyl ethanone and containing about 0.05% or less of 2-methyl-1-oxopropyl]-γ-oxo-N-β-diphenylbenzene butane amide. In that process the said diketone intermediate of formula 1 is obtained by maintaining temperature −25° C. to 50° C. during Friedel-Crafts acylation, in situ halogenation of formula II in presence of a solvent and nucleophilic substitution from a compound of formula III with formula IV in presence of a base.
US08946475B2 Processes for preparing a polymeric compound
The present invention provides methods for preparing a polymeric compound of Formula I: or pharmaceutically acceptable salt thereof. The present invention also provides useful intermediates for preparing the compound of Formula I or pharmaceutically acceptable salt thereof.
US08946470B2 Method for the oxidation of unsaturated organic compounds
A one-pot method for the oxidative cleavage of unsaturated carbon-carbon bonds to provide a carboxylic acid or a ketone-containing compound is disclosed. The method comprises contacting an alkene or an alkyne with hydrogen peroxide and a manganese transition metal catalyst having a ligand of formula (I):
US08946469B2 Process for preparing isopimaric acid
Disclosed is a process for preparing isopimaric acid, comprising the following steps: First step: dissolving thermally isomerized rosin in acetone, adding in drops a solution of isobutanolamine in acetone to form a precipitate, standing, filtering, washing with ethanol, and drying to obtain crude ammonium salt of isopimaric acid; recrystallizing the crude ammonium salt of isopimaric acid according to multi-recrystallization, and drying to obtain purified crystal of ammonium salt of isopimaric acid; Second step: dissolving the purified crystal of ammonium salt of isopimaric acid obtained in the first step in ether, adding hydrochloric acid in portions until the crystal of ammonium salt of isopimaric acid disappears, removing a water layer and washing the ether layer with water to neutral, evaporating the ether, dissolving the residue in acetone, adding water slowly into the solution dropwise until crystals cease to grow, then filtering and drying to obtain purified isopimaric acid.
US08946468B2 Process for producing ester compound having an internal unsaturated bond or cyclic olefin
A process for producing an unsaturated bond-containing ester compound includes reacting an internal olefin or a cyclic olefin having one carbon-carbon double bond or more at a position other than terminals of a molecule thereof (the internal olefin and the cyclic olefin may each contain a hetero atom) with a carboxylic acid in an amide-based solvent represented by a formula (1) in the presence of a palladium catalyst, a base, and molecular oxygen, to obtain an ester compound having an unsaturated bond.
US08946461B2 Recovery and purification of hydroxy fatty acids from source oils
A process for recovering, purifying and enriching hydroxy fatty acids from source oils. The process comprises the steps of: (a) methylating the source oil to form therein hydroxy fatty acid methyl esters and non-hydroxy fatty acid methyl esters; (b) separating the hydroxy fatty acid methyl esters from the non-hydroxy fatty acid methyl esters with an organic solvent mixture comprising a pentane/hexane and a short-chain alcohol; and (c) separately recovering the hydroxy fatty acid methyl esters and the non-hydroxy fatty acid methyl esters from the organic solvent mixture. Hydroxy fatty acids that can be recovered, purified and enriched with the process include ricinoleic acid, densipolic acid, lesquerolic acid, and auricolic acid. The non-hydroxy fatty acid methyl esters can be recovered, purified and further processed into biodiesel fuels and/or lubricants.
US08946459B2 Process for preparing EDDN and/or EDMN by reacting EDFA and/or EDMFA with HCN
A process for reacting ethylenediamine-formaldehyde adduct (EDFA) and/or ethylene-diamine-monoformaldehyde adduct (EDMFA) with hydrogen cyanide (HCN) in a reactor with limited backmixing at a temperature in the range from 20 to 120° C., wherein the residence time in the reactor is 300 seconds or less.
US08946458B2 Catalysts for hydrodeoxygenation of oxygenated hydrocarbons
The present invention provides catalysts, methods, and reactor systems for converting oxygenated hydrocarbons to oxygenated compounds. The invention includes methods for producing cyclic ethers, monooxygenates, dioxygenates, ketones, aldehydes, carboxylic acids, and alcohols from oxygenated hydrocarbons, such as carbohydrates, sugars, sugar alcohols, sugar degradation products, and the like, using catalysts containing palladium, molybdenum, tin, and tungsten. The oxygenated compounds produced are useful in the production of liquid fuels, chemicals, and other products.
US08946456B2 Process for the preparation of 2-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl-methanol and (R)-feso-deacyl
The present invention regards an improved and industrially advantageous process for the preparation of the 2-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl-methanol intermediates, also called “feso chromenyl” and (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol, also called “(R)-feso deacyl”, which are in turn used in the synthesis of fesoterodine and in particular of fesoterodine fumarate. This process utilises reagents which are non-toxic and manageable at industrial level and enables obtaining a new stable and non-hygroscopic crystalline form of the key intermediate “(R)-feso deacyl”, called form B.
US08946455B2 Semi-synthetic small molecules for the treatment parasitic disease
Small molecule therapeutics for the treatment of parasitic diseases, in particular, semi-synthetic derivatives of the fugally-derived natural product merulin A for the treatment of African Sleeping Sickness.
US08946439B2 Amide compounds, compositions and uses thereof
Compounds are provided according to formula 1: where A, B, W, X′, L, R1, R3, R4b, and m′ are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
US08946436B2 Oxazolidinone compounds and their uses in preparation of antibiotics
The invention belongs to the field of medicaments, and particularly relates to oxazolidinone compounds and their uses in the preparation of antibiotics. A technical problem to be solved by the invention is to provide new oxazolidinone compounds having the structure represented by Formula I. The oxazolidinone compounds of the invention, which are new compounds obtained through numerous screening, have significant antibacterial activity against bacteria such as drug-resistant staphylococcus aureus, fecal coliform bacteria, and streptococcus pneumoniae, while exhibiting low toxicity. The invention provides new options for the development and application of antibiotics.
US08946433B2 Process for the preparation of sufentanil base and related compounds
The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which advantageously utilizes more cost effective and/or less hazardous reagents, including a dispersion comprising between about 50% and about 70% by weight (based on the total weight of the dispersion) of an alkali metal hydride, such as sodium hydride, as well as eliminates the need for expensive and/or time consuming purification techniques.
US08946432B2 Biaryl derivatives as nAChR modulators
Disclosed is a compound of formula (I): wherein ‘D’, ‘E’, ‘m’, ‘n’ and R1-R4 are as described herein, as a modulator of nicotinic acetylcholine receptors particularly the α7 subtype, in a subject in need thereof, as well as analogues, prodrugs, isotopically substituted analogs, metabolites, pharmaceutically acceptable salts, polymorphs, solvates, isomers, clathrates, and co-crystal thereof, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds and analogues. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like.
US08946427B2 Triazolopyridine compounds
The invention is concerned with triazolopyridine compounds of formula (I) wherein R1, R2 and R3 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.
US08946426B2 Substituted bicyclic heterocyclic compounds as gamma secretase modulators
The present invention is concerned with substituted bicyclic heterocyclic compounds of Formula (I) wherein Het1, Het2, A1, A2, A3 and A4 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
US08946418B1 Chiral nitrogen-phosphorus ligands and their use for asymmetric hydrogenation of alkenes
The invention relates to a series of novel chiral nitrogen-phosphorus ligands of formulae (Ia) and (Ib): wherein R1-R3 and X are as defined herein. The invention also relates to chiral metal complexes prepared with these chiral nitrogen-phosphorus ligands. The chiral metal complexes are useful as catalysts for carrying out asymmetric hydrogenation.
US08946417B2 Synthesis of four coordinated platinum complexes and their applications in light emitting devices thereof
Platinum complexes that exhibit photoabsorption and photoemission, methods of making such complexes, and applications thereof are disclosed, including optical devices comprising the complexes.
US08946415B2 Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use
Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by adaptor associated kinase 1 activity are also disclosed.
US08946414B2 Processes for the preparation of dipyridamole
The present invention relates to the active pharmaceutical ingredient dipyridamole. In particular, it relates to efficient processes for the preparation of dipyridamole which are amenable to large scale commercial production and provide the required product with improved yield and purity. The present invention also relates to a novel crystallization method for the purification of dipyridamole.
US08946406B2 Derivatisation of erythropoietin (EPO)
The present invention relates to a compound which is a polysaccharide derivative of EPO, or of an EPO like protein, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide units. The present invention also relates to pharmaceutical compositions comprising the novel compounds, and methods for making the novel compounds.
US08946405B2 Controlled release from solid supports
The invention relates to solid supports useful in medical applications that provide controlled release of drugs, such as peptides, nucleic acids and small molecules. The drugs are covalently coupled to the solid support through a linkage that releases the drug or a prodrug through controlled beta elimination.
US08946404B2 Dark quenchers for donor-acceptor energy transfer
The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.
US08946401B2 Multi-targeting short interfering RNAs
The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.
US08946398B2 Infectious hepatitis C viruses of genotype 3A and 4A and uses thereof
The present invention relates to molecular approaches to the production of nucleic acid sequences, which comprises the genome of infectious hepatitis C virus. In particular, invention provides nucleic acid sequences which comprise the genomes of infectious hepatitis C viruses of either genotype 3a (strain S52) or genotype 4a (strain ED43). The invention therefore relates to the use of the nucleic acid sequences and polypeptides encoded by all or part of the sequences in the development of vaccines and diagnostic assays for HCV and in the development of screening assays for the identification of antiviral agents for HCV. The invention therefore also relates to the use of viral particles derived from laboratory animals infected with S52 and ED43 viruses.
US08946397B1 Tagged nucleosides that leave no scar upon cleavage
This invention provides compounds that are of the class of nucleoside analogs, and more specifically nucleoside analogs that have a non-standard nucleobase, and more specifically analogs where a side chain is appended to said non-standard nucleobase, where said side chain can be cleaved so as to leave behind no more than five atoms appended to the nucleobase as a “scar”. The claimed compounds are useful as intermediates in processes that transiently introduce tags, labels, fluorescent molecules, or other species into oligonucleotides, as in sequencing using cyclic reversible termination, in in vitro selection using functionalized nucleotides that must later be PCR amplified, or in nucleotide capture protocols used in diagnostics.
US08946396B2 Agglomerated particulate lignosulfonate
An agglomerated particulate lignosulfonate material may be made by introducing or forming lignosulfonate microparticles in a fluidized bed agglomerator, and introducing sufficient heated gas and lignosulfonate liquid in the agglomerator to convert the microparticles to lignosulfonate granules of enlarged size. The granules may have an average size of at least 0.1 mm, and may be used to make a dry-blended cement additive or oil well cement that may be dustless, easily poured and stored, and rapidly dissolved in water.
US08946394B2 Conjugate for photodynamic diagnosis or therapy and method for preparing same
The present invention relates to a conjugate of acetylated biocompatible polysaccharide and phthalocyanine-based compound for photodynamic diagnosis or therapy in which biocompatible polysaccharide is acetylated and a phthalocyanine-based compound is bound to the acetylated polysaccharide. The conjugate for photodynamic diagnosis or therapy according to the present invention is characterized in that the polysaccharide is acetylated to improve solubility in a solvent and thus enable various chemical modifications, and the conjugate may specifically target tumor cells, has superior cancer cell selecting and accumulating capacity, and has excellent effects of killing cancer cells when near infrared ray is irradiated. The conjugate of the present invention may not show cytotoxicity for cells other than cancer cells even when near infrared ray is irradiated, and thus exhibits superior in vivo stability, and therefore, may be valuably used in disease diagnosis or therapy using photodynamics.
US08946393B2 Methods for diagnosing lyme disease
A method for diagnosing Lyme disease status in a mammal is provided. The method entails, in a biological sample obtained or derived from a mammal, determining antibodies to Borrelia burgdorferi (B. burgdorferi) outer surface proteins (Osp) OspA, OspC, and OspF. Based upon determining the OspA, OspC, and OspF antibodies, the mammal can be diagnosed as vaccinated, not vaccinated, infected or not infected with B. burgdorferi. Mammals that have early, intermediate or chronic B. burgdorferi infection can also be identified. The method is particularly suited for use with horses and dogs. Isolated or recombinant B. burgdorferi antigens and compositions that contain them are also provided.
US08946391B2 Construction of a multivalent scFv through alkyne-azide 1,3-dipolar cycloaddition
The present invention provides for a practical, universal and efficient method to ligate two large macromolecules (e.g., proteins) using the alkyne-azide 1,3-dipolar cycloaddition reaction to produce a conjugated macromolecule, such as a multivalent scFv. The present invention also provides for conjugate macromolecules comprising a plurality of macromolecule components cross-linked through at least one linking group comprising at least one 1,2,3-triazole moiety, wherein at least 50 percent of the macromolecule components in the conjugate macromolecule has only one site available for cross-linking.
US08946390B2 Cancer-associated antigen
The present invention provides a novel cancer-associated antigen that can be used in the treatment and diagnosis of cancer. Further, the invention provides amino acid and nucleic acid sequence of the novel antigen, binding proteins, and immunoconjugates. The invention also relates to diagnostic and therapeutic methods and kits.
US08946387B2 FcγRIIB specific antibodies and methods of use thereof
The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, more particularly the extracellular domain of FcγRIIB with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA, and block the Fc binding site of FcγRIIB. The present invention also encompasses the use of an anti-FcγRIIB antibody or an antigen-binding fragment thereof, as a single agent therapy for the treatment, prevention, management, or amelioration of a cancer, preferably a B-cell malignancy, particularly, B-cell chronic lymphocytic leukemia or non-Hodgkin's lymphoma, an autoimmune disorder, an inflammatory disorder, an IgE-mediated allergic disorder, or one or more symptoms thereof. The present invention also encompasses the use of an anti-FcγRIIB antibody or an antigen-binding fragment thereof, in combination with other cancer therapies. The present invention provides pharmaceutical compositions comprising an anti-FcγRIIB antibody or an antigen-binding fragment thereof, in amounts effective to prevent, treat, manage, or ameliorate a cancer, such as a B-cell malignancy, an autoimmune disorder, an inflammatory disorder, an IgE-mediated allergic disorder, or one or more symptoms thereof. The invention further provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention with a vaccine composition. The invention further provides methods of treating cancer and/or regulating immune complex-mediated cell activation by administering the antibodies of the invention to enhance an immune response. The invention also provides methods of breaking tolerance to an antigen by administering an antigen-antibody complex and an antibody of the invention.
US08946386B2 Proteins expressed in NK cells
Purified immunocytes were analyzed for expression frequencies, and the NKIR gene expressed specifically in natural killer (NK) cells was successfully identified. The NKIR gene encodes a receptor. Agonists and antagonists for the receptor can be identified by using the receptor.
US08946382B2 Apelin peptides and methods of use
The present disclosure concerns the use of biologically active apelin peptides and compositions that are processed from larger precursor proteins and further post-translationally modified to influence cell growth. Particular methods are useful for promoting cell growth, while others are particularly useful for inhibiting cell growth.
US08946377B2 Highly functional polyetherols and the production and use thereof
The present invention relates to a process for preparing high-functionality polyetherols by reacting at least one trifunctional or higher-functionality alcohol and if appropriate further di- and/or monofunctional alcohols and/or modifying reagents, with the aid of acidic catalysts, where the trifunctional or higher-functionality alcohol is not glycerol. The present invention further relates to high-functionality polyetherols obtainable by such a process and to the use of these high-functionality polyetherols as adhesion promoters, thixotropic agents, rheology modifiers of polymers, phase transfer reagents, micro- or nanocontainers for biologically active compounds, for example for active medical ingredients, biocides, herbicides or fungicides, as pigment dispersants, an additive in printing inks or as structural units for preparing polyaddition or polycondensation polymers or for treatment of seed.
US08946373B2 Polyureas preparable from two polyetheramines and a prepolymer
The invention relates to a polyurea preparable from a) a component A comprising a1) 5 to 40% by weight of at least one polyetheramine 1 (PEA 1), obtainable from at least one polyetherpolyol 1 (PEP 1) and at least one amine 1, where PEP 1 has an equivalent weight of ≦500, a2) 30 to 90% by weight of at least one polyetheramine 2 (PEA 2), obtainable from at least one polyetherpolyol 2 (PEP 2) and at least one amine 2, where PEP 2 has an equivalent weight of >500, a3) 5 to 30% by weight of at least one amine chain extender and b) a component B, which is a prepolymer, obtainable from b1) at least one polyetherpolyol (PEP 3) and b2) at least one isocyanate.
US08946366B2 Cyclic olefin compound, photoreactive polymer, and alignment layer comprising the same
Disclosed herein are a cyclic olefin compound, a photoreactive polymer, and an alignment layer comprising the photoreactive polymer, where the cyclic olefin compound can be used to provide the photoreactive polymer having not only excellences in liquid crystal alignment and alignment rate but also readiness for change in the alignment direction depending on the polarization direction.
US08946361B2 Polyisobutylene prepared at high velocity and circulation rate
A method of making a polyisobutylene polymer in a recirculating loop reactor with one or more reaction tubes in contact with a heat transfer medium includes controlling the delta P and polymerization reaction to provide a linear velocity of the reaction mixture of at least 11 ft/sec in the one or more tubes of the loop reactor and/or controlling the delta P and polymerization reaction of steps (b) and (c) to provide a recirculation ratio of the recirculation rate to the feed rate of at least 30:1. Typically, the process utilizes a recirculating pump operating at a at a pressure differential of from 35 psi to 70 psi.
US08946355B2 Hydroxyaryl functionalized polymers
A functionalized polymer includes the reaction product of a reactive polymer and a compound that includes an aryl group having at least one directly bonded OGp substituent, where Gp is a protecting group, and a substituent (Q) which is free of active hydrogen atoms and which is, or connects to the aryl group through, a moiety that includes a carbon-to-nitrogen multiple bond. The polymer can be provided from a solution that includes one or more types of ethylenically unsaturated monomers which include at least one type of polyene, particularly one or more conjugated dienes in certain embodiments. An active terminus of the resulting reactive polymer can react with the Q substituent of the compound so as to provide a polymer having as a terminal functionality the radical of a compound that includes an aryl group having at least one directly bonded OGp substituent.
US08946353B2 Curable organopolysiloxane composition, optical semiconductor element sealant, and optical semiconductor device
A hydrosilylation reaction-curable organopolysiloxane composition comprising (A) a methylpheny-lalkenylpolysiloxane that has at least two alkenyl groups wherein diphenylsiloxane units are no more than 5 mole % and at least 20 mole % is comprised of phenyl groups, (B) a methylphenylhydrogenpolysiloxane that has at least two Si-bonded hydrogen atoms wherein diphenylsiloxane units are no more than 5 mole % and at least 20 mole % is comprised of phenyl groups, and (C) a hydrosilylation reaction catalyst. An optical semiconductor element sealant comprising this composition. An optical semiconductor device sealed with this optical semiconductor element sealant.
US08946350B2 Curable composition
Provided are a curable composition and its use. The curable composition can exhibit excellent processibility and workability. The curable composition exhibits excellent light extraction efficiency, hardness, thermal and shock resistance, moisture resistance, gas permeability and adhesiveness, after curing. In addition, the curable composition can provide a cured product that exhibits long-lasting durability and reliability even under harsh conditions, and that does not cause whitening and surface stickiness.
US08946346B2 Polymer having unsaturated cycloaliphatic functionality and coating compositions therefrom
A polymer is provided that preferably includes at least one unsaturated cycloaliphatic group. In one embodiment, the polymer is combined with an optional crosslinker and an optional carrier to form a coating composition suitable for use in coating articles such as packaging articles. In one embodiment, the polymer has at least one unsaturated cycloaliphatic group that is at least bicyclic.
US08946344B2 Curable resin compositions, coatings, and laminated plastics including the same
The present invention provides a curable resin composition including: a composite resin (A) in which a polysiloxane segment (a1), which has a structural unit represented by a general formula (1) and/or a general formula (2) as well as having a silanol group and/or a hydrolyzable silyl group, and a vinyl-based polymer segment (a2) having an alcoholic hydroxyl group are bound to each other through a bond represented by a general formula (3); and a polyisocyanate (B), wherein the content of said polysiloxane segment (a1) is from 10 to 60% by weight with respect to the total solid content of the curable resin composition, and the content of the polyisocyanate (B) is from 5 to 50% by weight with respect to the total solid content of the curable resin composition.
US08946337B2 Thermoplastic resin composition and molded product using the same
Provided are a thermoplastic resin composition including a thermoplastic resin and an amorphous sheet-shaped metal particle having a ratio of thickness relative to long diameter of about 1:20 to about 1:1, and a molded product using the same.
US08946334B2 Rubber composition for tires and pneumatic tire using the same
A rubber composition for tires, which includes a rubber component containing a natural rubber component consisting of at least either a natural rubber or an epoxidized natural rubber, and an inorganic filler containing silica, and a pneumatic tire using such a rubber composition for tires are provided. The rubber composition can be used as a rubber composition for clinch apex, and in this case, the rubber component preferably consists of the natural rubber component, with the inorganic filler being contained in a range of 50 to 80 parts by mass and carbon black being contained in a range of 2 to 5 parts by mass relative to 100 parts by mass of the rubber component. The rubber composition for tires can be used as a rubber composition for a bead apex, and in this case, the inorganic filler contains silica and clay, and the compounding amount of the clay is set in a range of 5 to 40 parts by mass relative to 100 parts by mass of the rubber component, with the total compounding amount of the silica and clay being set to 65 parts by mass or more relative to 100 parts by mass of the rubber component.
US08946333B2 Thermally conductive plastic compositions, extrusion apparatus and methods for making thermally conductive plastics
A thermally conductive filler composition and a resin composition comprising such filler compositions. The filler composition comprises a blend of a boron nitride, a metal oxide, and a silane. The filler composition can further comprise other filler components including, for example, glass fiber or glass flake. The filler compositions can be added to a resin composition to provide a thermally conductive resin such as, for example, a thermally conductive plastic.
US08946332B2 Flow enhanced thermoplastic compositions and methods for enhancing the flow of thermoplastic compositions
A composition that contains from 30 to 95 wt. %, based on the total weight of the composition, of a thermoplastic component and an effective amount of a flow-enhancing component. The effective amount of the flow-enhancing component reduces the viscosity of the composition by at least 10% compared to the viscosity of a composition comprising the thermoplastic component, but not an effective amount of the flow-enhancing component. The thermoplastic component is selected from the group consisting of polycarbonates, polyesters, and combinations thereof. The flow-enhancing component comprises b1) a component selected from the group consisting of metal oxides, metalloid oxides, metal alkoxides, metalloid alkoxides, and combinations thereof and b2) a mineral filler component. The weight ratio of component b1) to component b2) ranges from 1:25 to 25:1. A method for enhancing the flow of compositions comprising thermoplastic components is also disclosed.
US08946329B2 Coating compositions
Embodiments of the present disclosure are directed towards coating compositions comprising from 50 to 85 percent of an aqueous dispersion based on a total weight of the coating composition; a stabilizing solvent composition comprising a first alcohol and a second alcohol, wherein each alkyl chain of the first alcohol and the second alcohol is one to three carbon atoms, with the proviso that neither the first alcohol nor the second alcohol is propylene glycol; a basic water composition; and a crosslinker.
US08946328B2 Resin composition used for peelable coating and compounding process thereof
The present invention provides a resin composition used for peelable coating and compounding process thereof. The composition includes the following components: (a) 100 parts by weight of film-forming resin containing at least one acrylic resin; (b) 0.1-40 parts by weight of at least one separating agent, which is polypropylene glycol or glycerin fatty acid ester or their mixtures; and (c) 40-60 parts by weight of at least one solvent. The peelable coating formed from the resin composition has excellent water resistance and excellent peeling performance even under the condition of prolonging storage period.
US08946322B2 Thermosetting resin containing irradiated thermoplastic toughening agent
Thermosetting resins are provided that are toughened with an irradiated thermoplastic toughening agent and which have reduced levels of solvent-induced micro crack formation. The thermoplastic toughening agent is treated with a sufficient amount of high-energy radiation (e.g. electron beam or gamma rays) to cause a reduction in solvent-induced micro crack formation in the cured resin when compared to the same toughened thermosetting resin in which the non-irradiated version of the thermoplastic toughening agent is used.
US08946319B2 Butyl ionomers for use in reducing a population of and/or preventing accumulation of organisms and coatings made therefrom
The invention relates to the use of butyl ionomers or partially halogenated butyl ionomers in reducing a population of and/or preventing accumulation of organisms. The organisms may be bacteria, algae, fungi, mollusca or arthropoda. The invention also relates to coatings for shaped articles comprising the butyl ionomers.
US08946318B2 Kit of material for repairing dentin
The present invention discloses a kit of material for dentin restoration including a combination of a plurality of kinds of curable pastes each having a different hue, wherein each of the curable pastes exhibits L* of 55 to 75 and a fluctuation range of L* of 3 or less in a CIELab color system when the color of a cured body with a thickness of 3.0 mm obtained by curing the pastes is measured against a black background, and a method for producing the kit of material for dentin restoration.
US08946317B2 Composition for hard tissue repair
The composition for hard tissue repair of the present invention is characterized by comprising 5 to 98.95 parts by weight of a monomer (A), 1 to 75 parts by weight of a (meth)acrylate polymer (B) and 0.05 to 20 parts by weight of a polymerization initiator composition (C) containing an organoboron compound (c1), with the proviso that the total amount of the components (A), (B) and (C) is 100 parts by weight. The composition undergoes small-scale heat generation during curing and can ensure a sufficient working time.
US08946312B2 Azeotrope-like compositions comprising 1-chloro-3,3,3-trifluoropropene
An azeotrope-like mixture consisting essentially of chlorotrifluoropropene and at least one component selected from the group consisting of a C1-C3 alcohol, a C5-C6 hydrocarbon, a halogenated hydrocarbon, methylal, methyl acetone, water, nitromethane, and combinations thereof.
US08946310B2 Composition containing specific amides and organomodified siloxanes, suitable for producing polyurethane foams
Compositions suitable for producing polyurethane foams which include at least a polyol component, a catalyst catalyzing the formation of a urethane or isocyanurate bond, optionally a blowing agent, optionally further additives and optionally an isocyanate component, which are characterized in that they additionally include an admixture including at least one specific amide and at least one siloxane compound, wherein the mass ratio of siloxane compounds to compounds of formula (I) is above 1:10.
US08946309B2 Process to generate synthesis gas and/or liquid raw materials and/or energy materials from waste and/or biomass
Process to generate synthesis gas and/or liquid raw materials and/or energy materials from waste and/or biomass by performing the following steps: a) solvolysis of the organic components of waste and/or biomass in an alkaline solution or hydrate smelter at a temperature range of 150° to 250° C. and pressure between 3 and 12 bar, whereby the organic components are converted into at least one liquid phase and the inorganic components are sedimented; b) elimination of the inorganic components from the liquid phase by physical separation methods; c) transfer of the vapors generated during the solvolysis into a rectification column, where the organic components are separated from water; and d) further separation of the organic components by rectification, extraction and sorption and/or conversion by thermal gasification into synthesis gas or burnable gas.
US08946307B2 Biomass gasification gas purification system and method and methanol production system and method
A biomass gasification gas purification system includes a dust collector for removing dust in biomass gasification gas (containing tar components) acquired by gasifying biomass by a biomass gasification furnace, a desulfurizer for removing sulfur oxide components in the dust-removed biomass gasification gas, a pre-reforming reactor for reforming tar components in the desulfurized biomass gasification gas, a steam feed unit for feeding steam to an upstream side of the pre-reforming reactor, and a natural-gas feed unit for feeding natural gas on an upstream side of the desulfurizer.
US08946304B2 Methods of treating malnutrition
Methods of treating malnutrition are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.
US08946300B2 Use of rasagilline for the treatment of restless legs syndrome
Methods for the treatment of Restless Legs Syndrome using R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof.
US08946298B2 Plant disease controlling composition and method for controlling plant disease
The present invention provides a composition having an excellent controlling activity on plant disease. The composition comprising the compound represented by the formula (1) and one or more guanidine fungicidal compound selected from the group (A) shows an excellent controlling activity on a plant disease. group (A): a group consisting of dodine, iminoctadine trialbesilate, iminoctadine triacetate, and guazatine
US08946297B2 Solid composition for pest control
To provide an anthranilamide formulation compound for improving pest controlling effects.A solid composition for pest control which comprises an amorphous anthranilamide compound or its salt as a pesticidal active ingredient, a nonionic surfactant and/or an anionic surfactant and a mineral carrier.
US08946295B2 Histone hyperacetylating agents for promoting wound healing and preventing scar formation
A method for promoting wound healing and preventing scar formation in a variety of wounds in skin, mucosa, and cornea. The method comprises administering a therapeutically effective amount of a histone deacetylase inhibitor or a hyperacetylating agent. The histone deacetylase inhibitor or hyperacetylating agent is capable of stimulating multiple cytokines/growth factors in the early phase of wound healing, and suppressing fibrogenic cytokines/growth factors in the late phase of tissue remodeling in the wound site, and is useful in promoting epithelial cell re-growth and reducing excessive collagen accumulation, which results in rapid wound closure with reduced scaring.
US08946292B2 Formulations of low dose diclofenac and beta-cyclodextrin
The present invention is directed to a pharmaceutical composition containing a unit dose of a diclofenac compound effective to induce analgesia; and a beta-cyclodextrin compound; wherein the dose of the diclofenac compound is less than 75 mg, e.g., from about 18.75 mg to about 37.5 mg. The present invention is also directed to methods of treating a subject in need of analgesia with the pharmaceutical compositions of the invention.
US08946290B2 Combination of selected opioids with muscarine antagonists for treating urinary incontinence
Active compound combinations of compounds of group A, particularly opioids such as (+)-(2R,3R)-1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol or a salt thereof with a physiologically tolerated acid, and compounds of group B, particularly anti-muscarine agents such as oxybutynin or a salt thereof with a physiologically tolerated acid suitable for treatment of an increased urge to urinate or urinary incontinence. Related pharmaceutical formulations and methods of treatment of an increased urge to urinate or urinary incontinence are also provided.
US08946289B2 Manassatin compounds and methods of making and using the same
Provided are manassantin compounds and methods of using the compounds. Provided are methods of treating a disease, the method comprising administering a compound according to Formula I. Further provided are pharmaceutical compositions comprising compounds according to Formula I. Also provided are methods of inhibiting HIF-1 in a cell, the methods comprising administering to the cell a compound according to Formula I.
US08946288B1 Uses of hydroxyl polymethoxylflavones (HPMFs) and derivatives thereof
The invention discloses the uses of hydroxyl polymethoxylflavones and derivative thereof that are relative to inhibit adipogenesis and lower lipid accumulation, wherein the hydroxyl polymethoxylflavones is obtained from the peels of Citrus genus plants. Therefore, the hydroxyl polymethoxylflavones that of a therapeutically effective amount not only can be a medical compound for treatment obesity or fatty liver, but also can be a food element.
US08946275B2 Treatment of cancer using hypoxia activated prodrugs
Cancer can be treated by administration of a hypoxia-activated prodrug, such as TH-302, alone or in combination with other anticancer agents and/or radiation therapy. In combination therapy, the hypoxia-activated prodrug and another anti-cancer agent or radiation therapy may be administered within the same 24-hour period, and administration of the hypoxia-activated prodrug may be completed prior to beginning administration of the other anticancer agent or radiation therapy.
US08946274B2 Methods of improving skin quality
Methods of improving skin quality are disclosed. Generally, the methods include topically administering an IRM compound to a treatment area of skin for a period of time and in an amount effective for improving the quality of the skin. Suitable IRM compound compounds include agonists of one or more TLRs.
US08946273B2 S-Triazolyl alpha-mercapto acetanilides as inhibitors of HIV reverse transcriptase
A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
US08946266B2 Substituted triazole and imidazole derivatives as gamma secretase modulators
The present invention is concerned with novel substituted triazole and imidazole derivatives of Formula (I) wherein R1, R2, A1, A2, A3, A4, X, and Het1 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
US08946264B2 Pyridine derivative
The present invention relates to a novel pyridine derivative or a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt of the derivative or ester, which has an excellent hypoglycemic effect or treats and/or prevents the onset of a disorder of carbohydrate or lipid metabolism or a disease mediated by peroxisome proliferator-activated receptor (PPAR) γ. A compound represented by the general formula (I): [wherein R represents a pyridyl group substituted with 1 to 3 group(s) independently selected from Substituent Group A, and Substituent Group A represents a halogen atom, a C1-C6 alkyl group and a C1-C6 alkoxy group] or a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt of the compound or ester.
US08946263B2 Compositions and methods for modulating circadian synchronization
The present invention relates to a modulator of glucocorticoid biosynthesis, degradation and/or receptor activation for use in preventing or treating symptoms and/or diseases associated with jet lag. The compositions of the invention may be used as a lead compound for developing a drug for preventing or treating symptoms and/or diseases associated with jet lag. The invention relates to the discovery that administration of the modulator(s) to a subject results in a directional change of the time point of maximum amounts of glucocorticoids in the subject as compared to the time point of maximum amounts of glucocorticoids in a subject not treated with the modulator(s).
US08946262B2 Methods of preventing and treating gastrointestinal dysfunction
Methods of preventing and treating gastrointestinal dysfunction, particularly postoperative ileus and post-partum ileus, in a patient undergoing surgery or other biological stress by administering 4-aryl-piperidine derivatives are disclosed.
US08946257B2 N-containing heteroaryl derivatives as JAK3 kinase inhibitors
N-containing heteroaryl derivatives of formula I or II, wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as JAK, particularly JAK3, kinase inhibitors.
US08946255B2 Substituted morphinans and the use thereof
The application is directed to compounds of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4a, and R4b are defined as set forth in the specification. The invention is also directed to use of compounds of Formula I to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the present invention are especially useful for treating pain.
US08946253B2 Systems and methods for treating an opioid-induced adverse pharmacodynamic response
Disclosed in certain embodiments is a method of treating or preventing an opioid-induced adverse pharmacodynamic response comprising administering to a patient in need thereof an effective amount of buprenorphine.
US08946252B2 Methods of treating traveler's diarrhea and hepatic encephalopathy
Treatment of traveler's diarrhea using in subjects having hepatic encephalopathy using gastrointestinal specific antibiotics is disclosed. One example of a gastrointestinal specific antibiotic is rifaximin.
US08946234B2 Halogen-substituted compounds
The invention relates to compounds of the general formula (I), in which the radicals A1, A2, A3, A4, Lm, Q, R1, T and U have the meaning given in the description and to the use of the compounds for controlling animal pests. In addition, the invention relates to processes and intermediates for the preparation of the compounds according to formula (I).
US08946233B2 Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
US08946230B2 Aryl- and heteroaryl- nitrogen-heterocyclic compounds as PDE10 inhibitors
Aryl- and heteroaryl-nitrogen heterocyclic compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein m, p, q, R1, R2, R3, X1, X2, X3, Y1 and Y2 are defined herein; and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive-compulsive disorder, and the like.
US08946228B2 Piperidine/piperazine derivatives
The invention relates to a DGAT inhibitor of formula (I), including any stereochemically isomeric form thereof, a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof, and methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine, as a DGAT inhibitor, of said compounds.
US08946221B2 Phthalazine derivatives as PARP inhibitors
The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, L1, L2, X, Y, Q and Z have defined meanings.
US08946217B2 Pharmaceutical compounds
Fused pyrimidines of formula (I): wherein R1-R3, A and n have any of the values described in the specification; and pharmaceutically acceptable salts thereof; have activity as inhibitors of PI3K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders. Processes for synthesizing the compounds are also described.
US08946215B2 Hydroxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use
The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
US08946214B2 Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer
The present application is directed to an efficient conversion of C-14 hydroxylated morphine alkaloids to various morphine analogs, such as naltrexone, naloxone and nalbuphone. One feature of this process is an intramolecular functional group transfer from the C-14 hydroxyl to the N-17 nitrogen atom following a palladium-catalyzed N-demethylation.
US08946212B2 Annelated N-heterocyclic sulfonamides with oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals
Annelated N-heterocyclic sulfonamides with oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals The invention relates to annelated N-heterocyclic sulfonamides with oxadiazolone headgroup and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta or PPARdelta and PPARalpha agonist activity. What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.
US08946210B2 Fused aminodihydrothiazine derivatives
A compound represented by the general formula: or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like (wherein Re is a hydrogen atom or the like), Ring B is a C6-14 aryl group or the like, X is a C1-3 alkylene group or the like, Y is a single bond or the like, Z is a C1-3 alkylene group or the like, R1 and R2 are each independently a hydrogen atom or the like, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
US08946207B2 Processes for preparing 3-benzazepines
The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
US08946201B2 Methods for inhibiting TGF-β
The present invention provides methods for inhibiting or blocking TGF-β activity in cells and/or tissues expressing TGF-β comprising, contacting cells and/or tissues expressing TGF-β with an amount of cholesterol or cholesterol derivative effective to inhibit the activity of TGF-β. The present invention further provides a method for treating a condition associated with overactivity of TGF-β or negative regulation in normal physiology by TGF-β in a subject in need of treatment, comprising contacting cells and/or tissue overexpressing TGF-β in the subject with an amount of cholesterol or cholesterol derivative effective to inhibit activity of TGF-β thereby treating the condition. In a preferred embodiment, the cholesterol derivative is oxidized 7-DHC.
US08946200B2 Pharmaceutically active nanosuspensions
The present disclosure is directed at a pharmaceutically active nanoparticle suspension that may be optically clear. Such suspensions may be formed by selective dissolution of a pharmaceutically active compound in a first solvent followed by introduction into a second solvent, such as an aqueous medium, without substantial use of surfactants and/or mechanical shear.
US08946199B2 Co-administration of steroids and Zoledronic acid to prevent and treat side effects from Zoledronic acid infusion
Zoledronic Acid is used for treatment of hypercalcemia of malignancy, for the treatment of bone metastasis associated with malignancies such as prostate and breast cancer, for the prevention of and treatment of osteoporosis and for the treatment of Paget's disease. Administration of Zoledronic Acid is complicated by what is described as “post-dosing syndrome” (PDS) and osteonecrosis of the jaw (ONJ). Inflammation may be the cause of these side effects, which could be decreased by the co-administration of steroids. This application is a method of use patent for the co-administration of steroids (oral, IV, IM, rectal, or by inhalation) with Zoledronic Acid and a composition of matter patent for mixing Methyl Prednisolone with Zoledronic Acid for infusion.
US08946190B2 Medium-chain length fatty acids, salts and triglycerides in combination with gemcitabine for treatment of pancreatic cancer
The present invention relates to the use of medium-chain length fatty acids of formula I, triglycerides of formula 2 (wherein n=6-10), salts thereof, or mixtures thereof, in combination with gemcitabine and optionally erlotinib in the treatment of pancreatic cancer in human patients. Exemplary medium-chain length fatty acid/triglyceride compounds include capric acid, sodium caprate, tricaprin, lauric acid, sodium laurate, and trilaurin.
US08946186B2 QSOX1 as an anti-neoplastic drug target
The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.
US08946180B2 Means and methods for the specific modulation of target genes in the CNS and the eye and methods for their identification
Provided are methods for the treatment of disorders of the central nervous system (CNS) and the eye. In particular, use of compositions comprising a compound capable of modulating a target gene or gene product is described for the preparation of a pharmaceutical composition for the treatment of disorders of the CNS and/or the eye, wherein the composition is designed to be administered outside the blood-CNS and the blood-retina barriers. Furthermore, methods are provided for identifying and obtaining nucleic acid molecules encoding polypeptides involved in CNS disorders or of the eye, methods for diagnosing said disorders as well as transgenic animal deficient in the expression of target genes identified in accordance with the described method. In addition, methods of identifying and isolating drugs that are particularly useful for the treatment of disorders related to the CNS and/or the eye are disclosed.
US08946175B1 Stabilized immunomodulatory oligonucleotides
The invention provides immunostimulatory oligonucleotides having at least one CpG dinucleotide and a secondary structure at the 5′- or 3′-end. These oligonucleotides have either reduced or improved immunostimulatory properties. The invention establishes that 5′-terminal secondary structures affect immunostimulatory activity significantly more than those at the 3′-end. The invention also provides methods for increasing or decreasing the immunostimulatory activity of a CpG-containing nucleic acid.
US08946168B2 Compositions and methods for identifying and targeting cancer cells of alimentary canal origin
Screening and diagnostic reagents, kits and methods for primary and/or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or metastatic stomach or esophageal cancer are disclosed. Vaccines compositions and methods of for treating and preventing primary and/or metastatic stomach or esophageal cancer are disclosed.
US08946167B2 Pharmaceutical compositions containing plasma protein
The invention is related to water-soluble products and pharmaceutical formulations in solid or liquid form mainly for parenteral use. They consist of or comprise a therapeutically active substance (having low aqueous solubility and a substantial binding affinity to plasma proteins) and a plasma protein fraction in controlled aggregation state, whereby the said active substance and the said protein fraction are bound to each other by way of non-covalent bonds. It also covers processes for the preparation of the product and pharmaceutical formulation by dissolving the water-insoluble active substance in a water-miscible, pharmaceutically acceptable solvent, combining said solution with the aqueous solution of a plasma protein fraction in controlled aggregation state whereby a true solution is obtained containing the said active substance and the said protein fraction bound together by way of non-covalent bonds. Optionally a further pharmaceutically acceptable auxiliary additive—such as a protein aggregation controller and/or a stabilizer—may be present. The organic solvent is eliminated by dialyzing, ultrafiltrating, diafiltrating and/or lyophilizing. The solid products consisting of the active substance and the protein are also protected. On optional dissolution in water clear, liquid compositions are obtained suitable for direct parenteral or other administration. Method of treatment is also covered. A series of water-insoluble substances is enlisted with appropriate protein fractions to be used.
US08946165B2 Compounds for reversing and inhibiting protein aggregation, and methods for making and using them
The invention provides compositions for increasing the clearance of protein aggregates, and pharmaceutical compositions comprising them, and methods for making and using them, including methods for accelerating protein aggregate clearance in the CNS, e.g., for treating diseases that are characterized by protein aggregation—including some degenerative neurological diseases such as Parkinson's disease. In one aspect, the compositions of the invention specifically target synuclein, beta-amyloid and/or tau protein aggregates, and the methods of the invention can be used to specifically prevent, reverse, slow or inhibit synuclein, beta-amyloid and/or tau protein aggregation. In alternative embodiments, the compositions and methods of the invention, are used to treat, prevent, reverse (partially or completely) or ameliorate (including slowing the progression of) degenerative neurological diseases related to or caused by protein aggregation, e.g., synuclein, beta-amyloid and/or tau protein aggregation. In one aspect, compositions and methods of this invention are used to treat, prevent or ameliorate (including slowing the progression of) Parkinson's disease, fronto-temporal dementia (FTD), Alzheimer's Disease (AD), Lewy body disease (LBD) and Multiple system atrophy (MSA).
US08946163B2 Cross-linked collagen comprising metallic anticancer agents
The disclosure describes collagen constructs comprising anticancer agents, preferably, platinum, and related methods.
US08946160B2 Nitric oxide amino acid esters for improving vascular circulation, and prophylaxis or treatment of a condition associated with impaired blood circulation
Use of nitric oxide amino acid esters for improving vascular circulation, and prophylaxis or treatment of a condition associated with impaired blood circulation, such as peripheral vascular disease. The nitric oxide amino acid esters may be co-administered with an antimicrobial in topical or transdermal compositions for improving vascular circulation, and prophylaxis or treatment of a condition associated with impaired blood circulation.
US08946153B2 Fast dissolving pharmaceutical composition
The subject invention is directed to a pharmaceutical composition comprising an open matrix network carrying a pharmaceutically active ingredient, wherein the open matrix network comprises levan.
US08946148B2 Modified insulin polypeptides and their uses
Modified insulin polypeptides and their uses thereof are provided.
US08946139B2 Liquid laundry composition
The present invention concerns liquid laundry formulations incorporating a modified lignin polymer.
US08946138B2 Metering cartridge for a water-conducting domestic appliance
A cartridge, in particular for use in water-conveying household appliances, encompassing an enzyme-containing preparation that contains at least one enzyme protein and has a specific heat capacity cp at 20° C. of less than 3.8 J/(g*K), preferably less than 3.0 J/(g*K), and is stocked in a cartridge or cartridge chamber having an internal volume of between 20 and 500 ml and an average wall thickness of between 0.1 and 2 mm, and the cartridge material has a specific heat capacity cp at 20° C. of between 1 and 2 J/(g*K), preferably between 1.15 and 1.9 J/(g*K), particularly preferably between 1.5 and 1.8 J/(g*K).
US08946137B2 Foamable skin washing agent
To provide a skin washing agent which is excellent in the foaming speed and the foam creaminess in washing therewith, and which, after washing therewith, is excellent in the moist feeling and the absence of pulling feeling of the skin and does not change the moisture content of skin. A foamable skin washing agent comprising (a) a fatty acid salt, (b) one or more selected from a homopolymer, a dipolymer and a terpolymer derived from a specific cationated monomer (e.g., dimethyldiallylammonium chloride), (c) a polyglyceryl monoalkyl ether, and (d) one or more selected from an acylmethyltaurine salt and a hydroxy ether carboxylate salt.
US08946135B2 Lubricating composition containing a nitrile compound
The invention provides a lubricating composition containing an oil of lubricating viscosity and a nitrile compound. The invention further relates to a method of the lubricating an internal combustion engine with the lubricating composition.
US08946131B2 Methods and compositions for consolidating particulate matter in a subterranean formation
Curable adhesive compositions comprising a silane coupling agent; a polymer, the polymer having a reactive silicon end group; a catalyst operable to facilitate the curing of the polymer; and, a diluent and wherein the polymer comprises about 0.1% to about 30% by weight of the curable adhesive composition. The curable adhesive compositions may further comprise a dehydrating agent comprising a component selected from the group consisting of: vinyl trimethoxysilane, vinyl alkoxysilane, inorganic zeolites, and organic zeolites.
US08946126B2 Precursor material for bi-based oxide superconductor and process for preparing such material
A precursor material for the preparation of superconductors based on Bi2Sr2Ca1Cu2O8+δ wherein the precursor material which is as close to equilibrium state as possible, i.e., has less than 5% in average 2201 intergrowths in the 2212 phase; in particular, the present invention relates to a precursor material, which is converted to the final conductor by partial melt processing, as well as to a process for the production of the precursor material and the use of the precursor material for preparing superconductors based on Bi2Sr2Ca1Cu2O8+δ.
US08946116B2 Nanometer powder catalyst and its preparation method
A TiO2-containing composite nano-powder catalyst obtained by combining a titanium-based metal ceramic compound in powder form with a mixing solution containing compound(s) of a platinum group metal and/or a non-noble metal, drying the resulting mixture, and then performing oxidative thermal decomposition on the dried mixture. This catalyst also can be used as a support to further support platinum group metal(s) and/or non-noble metal(s) to obtain another composite nano-powder catalyst. A method for preparing a TiO2-containing composite nano-powder catalyst is also disclosed.
US08946115B2 Catalysts for the preparation of methylpyridine
Subject of the invention is a dehydrogenation catalyst for dehydrogenating methylpiperidine to methylpyridine. Subject of the invention are also methods for preparing the catalysts obtained thereby and methods, in which the catalysts are used.
US08946114B2 Stable ferrous-ferric nitrate solutions for fischer-tropsch catalyst preparation
A method of producing stable ferrous nitrate solution by dissolving iron in nitric acid to form a ferrous nitrate solution and maintaining the solution at a first temperature for a first time period, whereby the Fe(II) content of the ferrous nitrate solution changes by less than about 2% over a second time period. A method of producing stable Fe(II)/Fe(III) nitrate solution comprising ferrous nitrate and ferric nitrate and having a desired ratio of ferrous iron to ferric iron, including obtaining a stable ferrous nitrate solution; dissolving iron in nitric acid to form a ferric nitrate solution; maintaining the ferric nitrate solution at a second temperature for a third time period; and combining amounts of stable ferrous nitrate solution and ferric nitrate solution to produce the stable Fe(II)/Fe(III) nitrate solution. A method of preparing an iron catalyst is also described.
US08946113B2 Iron-modified Ni-based perovskite-type catalyst, preparing method thereof, and producing method of synthesis gas from combined steam CO2 reforming of methane using the same
The present invention relates to an Fe-modified perovskite-type catalyst, a method for preparing same and a method for preparing a synthesis gas by a combined reforming reaction using same. More particularly, it relates to a catalyst for a combined natural gas/steam/carbon dioxide reforming reaction having a perovskite structure with La and Sr introduced at the A site and Ni and Fe introduced at the B site with specific molar ratios and a method for producing a synthesis gas for Fischer-Tropsch synthesis or methanol synthesis using the catalyst by the combined reforming reaction. The catalyst of the present invention exhibits higher carbon dioxide conversion rate, significantly reduced catalyst deactivation caused by carbon deposition and improved long-term catalyst stability and activity, as compared to the existing catalyst for reforming reaction prepared by the impregnation method.
US08946110B2 Process for preparing a catalytic composition for the hydroconversion of petroleum fractions
The invention relates to a method of preparing a catalytic composition comprising at least one non-noble metal from group VIII and at least one metal from group VIB of the periodic table. The invention also relates to the catalytic composition thus produced, which has a high specific activity in reactions involving the hydroprocessing of light and intermediate fractions, preferably in reactions involving the hydrotreatment of hydrocarbon streams, including hydrodesulphurization (HDS), hydrodenitrogenation (HDN) and hydro-dearomatization (HDA).
US08946109B2 Catalysts and methods for polymer synthesis
The present invention provides unimolecular metal complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are methods of using such metal complexes in the synthesis of polymers. According to one aspect, the present invention provides metal complexes comprising an activating species with co-catalytic activity tethered to a multidentate ligand that is coordinated to the active metal center of the complex.
US08946107B2 Process for the conversion of ethane to aromatic hydrocarbons
A process for producing aromatic hydrocarbons which comprises (a) contacting ethane with a dehydroaromatization aromatic catalyst which is comprised of 0.005 to 0.1% wt platinum, an amount of iron which is equal to or greater than the amount of the platinum, from 10 to 99.9% wt of an aluminosilicate, and a binder, and (b) separating methane, hydrogen, and C2-5 hydrocarbons from the reaction products of step (a) to produce aromatic reaction products including benzene.
US08946106B2 Process for the regeneration of a catalyst
Process for the regeneration of an at least partially coked molecular sieve catalyst comprising introducing the at least partially coked catalyst into a regenerator; introducing into the regenerator an oxygen-containing gas to regenerate at least part of the at least partially coked catalyst, thereby producing a gaseous mixture and at least partially regenerated catalyst; recovering part of the at least partially regenerated catalyst; analysing the at least partially regenerated catalyst to control the burning rate of the coke present on the at least partially coked catalyst in the regenerator by adjusting one or more conditions of the regeneration of the at least partially coked catalyst on the basis of the analysis of the at least partially regenerated catalyst; and separating at least partially regenerated catalyst and at least part of the gaseous mixture as obtained in step (b).
US08946103B2 Zircon compatible, ion exchangeable glass with high damage resistance
An ion exchangeable glass having a high degree of resistance to damage caused by abrasion, scratching, indentation, and the like. The glass comprises alumina, B2O3, and alkali metal oxides, and contains boron cations having three-fold coordination. The glass, when ion exchanged, has a Vickers crack initiation threshold of at least 10 kilogram force (kgf).
US08946101B2 Enhanced barrier multifunctional coatings for nylon films
High barrier multilayer films are disclosed that incorporate a selectively permeable outer layer and a moisture barrier nanocomposite membrane. More particularly, insulation facing materials and insulation articles can incorporate an insulation facing material having a variable vapor barrier. The facing materials can include a moisture barrier membrane that incorporates a nanoclay.
US08946100B2 Fibers of variable wettability and materials containing the fibers
The present invention is directed to an absorbent material and the fibers therein, having two or more layers including an upper surface layer which has on the outer surface of the layer one or more surface area zones which are more wettable zones and adjacent thereto one or more less wettable zones, where the more wettable zones have a greater hydrophilicity than the less wettable zone. The present invention is also directed to the fibers therein, which contain polyvalent cation-containing compounds and fatty acid containing compounds. The present invention also provides for methods of treating fibers or solid materials and processes of producing the hydrophobic materials.
US08946099B2 Transponder embedded in a flexible multilayer support
The transponder with an electronic unit comprising an antenna coil (4) connected to a chip module (5) embedded in a multi-layer laminate support (1) comprises at least one flexible thermoplastic layer (2) disposed on both sides of the electronic unit wherein the multi-layer laminate support further comprises a non-woven foil (3) with a grammage of less than 25 g/m2.
US08946090B2 Method for etching a layer on a silicon semiconductor substrate
A method for selective etching of an SiGe mixed semiconductor layer on a silicon semiconductor substrate by dry chemical etching of the SiGe mixed semiconductor layer with the aid of an etching gas selected from the group including ClF3 and/or ClF5, a gas selected from the group including Cl2 and/or HCl being added to the etching gas.
US08946089B2 Methods of forming contact holes
Methods of forming contact holes include forming a first guide pattern over an etching target layer. The first guide pattern has first openings each extending in a first direction and each first opening arranged in a direction perpendicular to the first direction. A first BCP structure is formed in each first opening. The first BCP structure includes first material layers in the first direction at a first pitch in each of the first openings, and second material layers filling a remaining portion of each first opening. First holes are formed by removing the first material layers. A second guide pattern is formed over the first guide pattern and the second material layers, and the above processes are performed on the second guide pattern to form second holes. Portions of the etching target layer overlapped by the first holes or the second holes are removed to form a desired pattern.
US08946087B2 Electroless copper deposition
A method for providing metal filled features in a layer is provided. A metal seed layer is deposited on tops and bottoms of the features. Metal seed layer on tops of the features and overhangs is removed without removing metal seed layer on bottoms of features. An electroless deposition of metal is provided to fill the features, wherein the electroless deposition first deposits on the metal seed layer on bottoms of the features.
US08946084B2 Controlling the device performance by forming a stressed backside dielectric layer
A device includes a p-type metal-oxide-semiconductor (PMOS) device and an n-type metal-oxide-semiconductor (NMOS) device at a front surface of a semiconductor substrate. A first dielectric layer is disposed on a backside of the semiconductor substrate. The first dielectric layer applies a first stress of a first stress type to the semiconductor substrate, wherein the first dielectric layer is overlying the semiconductor substrate and overlapping a first one of the PMOS device and the NMOS device, and is not overlapping a second one of the PMOS device and the NMOS device. A second dielectric layer is disposed on the backside of the semiconductor substrate. The second dielectric layer applies a second stress to the semiconductor substrate, wherein the second stress is of a second stress type opposite to the first stress type. The second dielectric layer overlaps a second one of the PMOS device and the NMOS device.
US08946083B2 In-situ formation of silicon and tantalum containing barrier
A method includes forming an opening in a dielectric layer, and forming a silicon rich layer on a surface of the dielectric layer. A portion of the silicon rich layer extends into the opening and contacts the dielectric layer. A tantalum-containing layer is formed over and the contacting the silicon rich layer. An annealing is performed to react the tantalum-containing layer with the silicon rich layer, so that a tantalum-and-silicon containing layer is formed.
US08946081B2 Method for cleaning semiconductor substrate
Embodiments of the invention include a method of cleaning a semiconductor substrate of a device structure and a method of forming a silicide layer on a semiconductor substrate of a device structure. Embodiments include steps of converting a top portion of the substrate into an oxide layer and removing the oxide layer to expose a contaminant-free surface of the substrate.
US08946078B2 Method of forming trench in semiconductor substrate
The present invention provides a method of forming a trench in a semiconductor substrate. First, a first patterned mask layer is formed on a semiconductor substrate. The first patterned mask layer has a first trench. Then, a material layer is formed along the first trench. Then, a second patterned mask layer is formed on the material layer to completely fill the first trench. A part of the material layer is removed when the portion of the material layer between the second patterned mask layer and the semiconductor substrate is maintained so as to form a second trench. Lastly, an etching process is performed by using the first patterned mask layer and the second patterned mask layer as a mask.
US08946069B2 Fabricating method of semiconductor device and semiconductor device fabricated using the same method
A fabricating method of a semiconductor device includes providing a substrate having a first region and a second region, forming a plurality of first gates in the first region of the substrate, such that the first gates are spaced apart from each other at a first pitch, forming a plurality of second gates in the second region of the substrate, such that the second gates are spaced apart from each other at a second pitch different from the first pitch, implanting an etch rate adjusting dopant into the second region to form implanted regions, while blocking the first region, forming a first trench by etching the first region between the plurality of first gates, and forming a second trench by etching the second region between the plurality of second gates.
US08946067B2 Method of making a thin crystalline semiconductor material
A method of preparing a thin material layer from a semiconductor substrate is presented. The method entails forming a stress-generating epitaxial layer on a base substrate to form a stressed region, and achieving separation along the stressed region to produce a first part and a second part. The stress-generating epitaxial layer may be boron-doped or a Si(1-x)—Gex material. The separation may be achieved with spalling or etching.
US08946066B2 Method of manufacturing semiconductor device
A highly reliable transistor which includes an oxide semiconductor and has high field-effect mobility and in which a variation in threshold voltage is small is provided. By using the transistor, a high-performance semiconductor device, which has been difficult to realize, is provided. The transistor includes an oxide semiconductor film which contains two or more kinds, preferably three or more kinds of elements selected from indium, tin, zinc, and aluminum. The oxide semiconductor film is formed in a state where a substrate is heated. Further, oxygen is supplied to the oxide semiconductor film with an adjacent insulating film and/or by ion implantation in a manufacturing process of the transistor, so that oxygen deficiency which generates a carrier is reduced as much as possible. In addition, the oxide semiconductor film is highly purified in the manufacturing process of the transistor, so that the concentration of hydrogen is made extremely low.
US08946061B2 Engineering of porous coatings formed by ion-assisted direct deposition
In one embodiment, a method of producing a porous semiconductor film on a workpiece includes generating semiconductor precursor ions that comprise one or more of: germanium precursor ions and silicon precursor ions in a plasma of a plasma chamber, in which the semiconductor precursor ions are operative to form a porous film on the workpiece. The method further includes directing the semiconductor precursor ions to the workpiece over a range of angles.
US08946059B2 Method and installation for producing a semiconductor device, and semiconductor device
A method of producing a semiconductor device is provided, the semiconductor device including a substrate, a semiconductor layer and at least one metallization layer adjacent to at least one element chosen from the substrate and the semiconductor layer, the method including forming at least one metallization layer which, adjacent to at least one element chosen from the substrate and the semiconductor layer, includes oxygen.
US08946057B2 Laser and plasma etch wafer dicing using UV-curable adhesive film
Laser and plasma etch wafer dicing using UV-curable adhesive films is described. In an example, a method includes forming a mask above the semiconductor wafer. The semiconductor wafer is coupled to a carrier substrate by a UV-curable adhesive film. The mask covers and protects the integrated circuits. The mask is patterned with a laser scribing process to provide a patterned mask with gaps. The patterning exposes regions of the semiconductor wafer between the integrated circuits. The semiconductor wafer is then etched through the gaps in the patterned mask to form singulated integrated circuits. The UV-curable adhesive film is then irradiated with ultra-violet (UV) light. The singulated integrated circuits are then detached from the carrier substrate.
US08946054B2 Crack control for substrate separation
A method for separating a layer for transfer includes forming a crack guiding layer on a substrate and forming a device layer on the crack-guiding layer. The crack guiding layer is weakened by exposing the crack-guiding layer to a gas which reduces adherence at interfaces adjacent to the crack guiding layer. A stress inducing layer is formed on the device layer to assist in initiating a crack through the crack guiding layer and/or the interfaces. The device layer is removed from the substrate by propagating the crack.
US08946052B2 Processes for multi-layer devices utilizing layer transfer
A method includes forming a release layer over a donor substrate. A plurality of devices made of a first semiconductor material are formed over the release layer. A first dielectric layer is formed over the plurality of devices such that all exposed surfaces of the plurality of devices are covered by the first dielectric layer. The plurality of devices are chemically attached to a receiving device made of a second semiconductor material different than the first semiconductor material, the receiving device having a receiving substrate attached to a surface of the receiving device opposite the plurality of devices. The release layer is etched to release the donor substrate from the plurality of devices. A second dielectric layer is applied over the plurality of devices and the receiving device to mechanically attach the plurality of devices to the receiving device.
US08946049B2 Replacement gate structures and methods of manufacturing
Gate structures and methods of manufacturing is disclosed. The method includes forming a continuous replacement gate structure within a trench formed in dielectric material. The method further includes segmenting the continuous replacement gate structure into separate replacement gate structures. The method further includes forming insulator material between the separate replacement gate structures.
US08946048B2 Method of fabricating non-volatile memory with flat cell structures and air gap isolation
High-density semiconductor memory is provided with enhancements to gate-coupling and electrical isolation between discrete devices in non-volatile memory. The intermediate dielectric between control gates and charge storage regions is varied in the row direction, with different dielectric constants for the varied materials to provide adequate inter-gate coupling while protecting from fringing fields and parasitic capacitances. Electrical isolation is further provided, at least in part, by air gaps that are formed in the column (bit line) direction and/or air gaps that are formed in the row (word line) direction.
US08946047B2 Method for fabricating capacitor
A method for fabricating a capacitor includes: forming a storage node contact plug over a substrate; forming an insulation layer having an opening exposing a surface of the storage node contact plug over the storage contact plug; forming a conductive layer for a storage node over the insulation layer and the exposed surface of the storage node contact plug through two steps performed at different temperatures; performing an isolation process to isolate parts of the conductive layer; and sequentially forming a dielectric layer and a plate electrode over the isolated conductive layer.
US08946046B1 Guided path for forming a conductive filament in RRAM
A method of forming a non-volatile memory device, includes forming a first electrode above a substrate, forming a dielectric layer overlying the first electrode, forming an opening structure in a portion of the dielectric layer to expose a surface of the first electrode having an aspect ratio, forming a resistive switching material overlying the dielectric layer and filling at least a portion of the opening structure using a deposition process, the resistive switching material having a surface region characterized by a planar region and an indent structure, the indent structure overlying the first electrode, maintaining a first thickness of resistive switching material between the planar region and the first electrode, maintaining a second thickness of resistive switching material between the indent structure and the first electrode, wherein the first thickness is larger than the second thickness, and forming a second electrode overlying the resistive switching material including the indent structure.
US08946041B2 Methods for forming high gain tunable bipolar transistors
Embodiments for forming improved bipolar transistors are provided, manufacturable by a CMOS IC process. The improved transistor comprises an emitter having first and second portions of different depths, a base underlying the emitter having a central portion of a first base width underlying the first portion of the emitter, a peripheral portion having a second base width larger than the first base width partly underlying the second portion of the emitter, and a transition zone of a third base width and lateral extent lying laterally between the first and second portions of the base, and a collector underlying the base. The gain of the transistor is larger than a conventional bipolar transistor made using the same CMOS process. By adjusting the lateral extent of the transition zone, the properties of the improved transistor can be tailored to suit different applications without modifying the underlying CMOS IC process.
US08946040B2 SOI lateral bipolar transistor having multi-sided base contact and methods for making same
A Bipolar Junction Transistor with an intrinsic base, wherein the intrinsic base includes a top surface and two side walls orthogonal to the top surface, and a base contact electrically coupled to the side walls of the intrinsic base. In one embodiment an apparatus can include a plurality of Bipolar Junction Transistors, and a base contact electrically coupled to the side walls of the intrinsic bases of each BJT.
US08946031B2 Method for fabricating MOS device
A method for fabricating a MOS device is described. A first hard mask layer is formed over a substrate. The first hard mask layer is patterned and a portion of the substrate removed to form a first patterned hard mask, and a fin structure surrounded by a trench and extending in a first direction. An insulating layer is formed at the trench bottom. A gate conductive layer is formed on the insulating layer, extending in a second direction. A first implant process is performed using the first patterned hard mask as a mask to form first S/D extension regions in the sidewalls of the fin structure. The first patterned hard mask is removed to expose the top of the fin structure, and then a second implant process is performed to form second S/D extension region therein.
US08946029B2 Methods of manufacturing integrated circuits having FinFET structures with epitaxially formed source/drain regions
Methods of manufacturing semiconductor integrated circuits having FinFET structures with epitaxially formed source and drain regions are disclosed. For example, a method of fabricating an integrated circuit includes forming a plurality of silicon fin structures on a semiconductor substrate, forming disposable spacers on vertical sidewalls of the fin structures, and depositing a silicon oxide material over the fins and over the disposable spacers. The method further includes anisotropically etching at least one of the fin structures and the disposable spacers on the sidewalls of the at least one fin structure, thereby leaving a void in the silicon oxide material, and etching the silicon oxide material and the disposable spacers from at least one other of the fin structures, while leaving the at least one other fin structure un-etched. Still further, the method includes epitaxially growing a silicon material in the void and on the un-etched fin structure. An un-merged source/drain region is formed in the void and a merged source/drain region is formed on the un-etched fin structure.
US08946028B2 Merged FinFETs and method of manufacturing the same
FinFETs are merged together by a metal. The method of manufacturing the FinFETs include forming a plurality of fin bodies on a substrate and merging the fin bodies with a metal. The method further includes implanting source and drain regions through the metal.
US08946025B2 Manufacturing method of thin film and metal line for display using the same, thin film transistor array panel, and method for manufacturing the same
A method for forming a thin film according to an exemplary embodiment of the present invention includes forming the thin film at a power density in the range of approximately 1.5 to approximately 3 W/cm2 and at a pressure of an inert gas that is in the range of approximately 0.2 to approximately 0.3 Pa. This process results in an amorphous metal thin film barrier layer that prevents undesired diffusion from adjacent layers, even when this barrier layer is thinner than many conventional barrier layers.
US08946020B2 Method of forming controllably conductive oxide
In fabricating a memory device, a first electrode is provided. An alloy is formed thereon, and the alloy is oxidized to provide an oxide layer. A second electrode is provided on the oxide layer. In a further method of fabricating a memory device, a first electrode is provided. Oxide is provided on the first electrode, and an implantation step in undertaken to implant material in the oxide to form a layer including oxide and implanted material having an oxygen deficiency and/or defects therein. A second electrode is then formed on the layer.
US08946019B2 Semiconductor device comprising a buried capacitor formed in the contact level
In a semiconductor device, capacitors may be formed so as to be in direct contact with a transistor by using a shared transistor region, such as a drain region or a source region of closely spaced transistors, as one capacitor electrode, while the other capacitor electrode is provided in the form of a buried electrode in the dielectric material of the contact level. To this end, dielectric material may be deposited so as to reliably form a void, wherein, at any appropriate manufacturing stage, a capacitor dielectric material may be provided so as to separate the capacitor electrodes.
US08946017B2 Method of making a TFT charge storage memory cell having high-mobility corrugated channel
Numerous other aspects are provided a method for making a nonvolatile memory cell. The method includes forming a non-planar dielectric structure, and conformally depositing a semiconductor layer over the dielectric structure. A portion of the semiconductor layer serves as a channel region for a transistor, and the channel region is non-planar in shape.
US08946009B2 Low extension resistance III-V compound fin field effect transistor
A gate stack including a gate dielectric and a gate electrode is formed over at least one compound semiconductor fin provided on an insulating substrate. The at least one compound semiconductor fin is thinned employing the gate stack as an etch mask. Source/drain extension regions are epitaxially deposited on physically exposed surfaces of the at least one semiconductor fin. A gate spacer is formed around the gate stack. A raised source region and a raised drain region are epitaxially formed on the source/drain extension regions. The source/drain extension regions are self-aligned to sidewalls of the gate stack, and thus ensure a sufficient overlap with the gate electrode. Further, the combination of the source/drain extension regions and the raised source/drain regions provides a low-resistance path to the channel of the field effect transistor.
US08946008B2 Organic light emitting diode display, thin film transitor array panel, and method of manufacturing the same
A thin film transistor array panel includes a substrate, a semiconductor that is positioned on the substrate and that has a source area, a drain area, and a channel area, a gate insulating layer that is positioned on the semiconductor, a gate electrode that is positioned on the gate insulating layer and that overlaps the channel area, a first interlayer insulating layer that is positioned on the gate electrode and that has contact holes that expose the source area and the drain area, respectively, of which the source area and the drain area have a same plane pattern as that of the contact holes, and a source electrode and a drain electrode that are positioned on the first interlayer insulating layer and that are connected to the source area and the drain area, through the contact holes, respectively.
US08946001B1 Method and apparatus for improving triggering uniformity of snapback electrostatic discharge protection devices
An electrostatic discharge (ESD) protection circuit includes a first array of transistors, having source and drain doped with a first type of material, arranged in parallel in a first block, and a second array of transistors, having source and drain doped with the first type of material, arranged in parallel in a second block. The ESD protection circuit also includes an active region between the first and second array of transistors doped with a second type of material that is complementary to the first type of material.
US08946000B2 Method for forming an integrated circuit having a programmable fuse
A back-end-of-line thin ion beam deposited fuse (204) is deposited without etching to connect first and second last metal interconnect structures (110, 120) formed with last metal layers (LM) in a planar multi-layer interconnect stack to programmably connect separate first and second circuit connected to the first and second last metal interconnect structures.
US08945996B2 Methods of forming circuitry components and methods of forming an array of memory cells
A method of forming circuitry components includes forming a stack of horizontally extending and vertically overlapping features. The stack has a primary portion and an end portion. At least some of the features extend farther in the horizontal direction in the end portion moving deeper into the stack in the end portion. Operative structures are formed vertically through the features in the primary portion and dummy structures are formed vertically through the features in the end portion. Horizontally elongated openings are formed through the features to form horizontally elongated and vertically overlapping lines from material of the features. The lines individually extend from the primary portion into the end portion, and individually laterally about sides of vertically extending portions of both the operative structures and the dummy structures. Sacrificial material that is elevationally between the lines is at least partially removed in the primary and end portions laterally between the horizontally elongated openings. Other aspects and implementations are disclosed.
US08945993B2 Method of manufacturing a ball grid array substrate or a semiconductor chip package
A method of manufacturing a ball grid array substrate includes: forming a first circuit pattern and a second circuit pattern on a first metal carrier and a second metal carrier, respectively; stacking a first insulating layer and a second insulating layer with a separable material interposed therebetween, wherein each of the first and second insulating layers has first and second surfaces opposing each other, and the first surface contacts the separable material; burying the first and second circuit patterns in the second surfaces of the first and second insulating layers, respectively; removing the first and second metal carriers; removing the separable material to separate the first and second insulating layers from each other; and forming an opening in each of the first and second insulating layers to connect the first and second surfaces with each other. The method may also be part of a process for manufacturing a semiconductor package.
US08945990B2 Chip package and method of forming the same
Embodiments provide a method of forming a chip package. The method may include attaching at least one chip on a carrier, the chip including a plurality of chip pads on a surface of the chip opposite to the carrier; depositing a first adhesion layer on the carrier and on the chip pads of the chip, the first adhesion layer including tin or indium; depositing a second adhesion layer on the first adhesion layer, the second adhesion layer including a silane organic material; and depositing a lamination layer or an encapsulation layer on the second adhesion layer and the chip.
US08945987B2 Manufacture of face-down microelectronic packages
In a high volume method for manufacturing a microelectronic package, a spacer element and a first die, i.e., microelectronic element, can be attached face-down to a surface of a substrate, contacts on the first die facing a first through opening of the substrate. Then, a second die can be attached face-down atop the first die and the spacer element, contacts on the second die disposed beyond an edge of the first die and facing a second through opening in the substrate. Electrical connections can then be formed between each of the first and second dies and the substrate. The first and second dies can be transferred from positions of a single diced wafer which are selected to maximize compound speed bin yield of the microelectronic package.
US08945985B2 Semiconductor package and method of manufacturing the same
A semiconductor package including an internal package including at least one semiconductor chip sealed with an internal seal, an external substrate on which the internal package is mounted, and an external seal sealing the internal package is provided. Also provided is a method of manufacturing the semiconductor package including forming an internal package including at least one semiconductor chip sealed with an internal seal, mounting the internal package on an external substrate, and sealing the internal package with an external seal. The internal seal and the external seal have different Young's moduli, for example, a Young's modulus of the internal seal is smaller than a Young's modulus of the external seal. Accordingly, the semiconductor package is less susceptible to warpage and can be handled with relative ease in subsequent semiconductor package processes.
US08945984B2 Bump-on-trace methods and structures in packaging
A method and structure for bump-on-trace bonding is provided. In an embodiment traces to be used for bump-on-trace (BOT) bonding are protected during a pre-solder treatment. The pre-solder treatment improves the adhesion between the exposed traces (e.g., the non-BOT traces) and a solder resist layer.
US08945980B2 Alkali metal-doped solution-processed metal chalcogenides
A method is provided for forming an alkali metal-doped solution-processed metal chalcogenide. A first solution is formed that includes a first material group of metal salts, metal complexes, or combinations thereof, dissolved in a solvent. The first material group may include one or more of the following elements: copper (Cu), indium (In), and gallium (Ga). An alkali metal-containing material is added to the first solution, and the first solution is deposited on a conductive substrate. The alkali metal-containing material may be sodium (Na). An alkali metal-doped first intermediate film results, comprising metal precursors from corresponding members of the first material group. Then, thermally annealing is performed in an environment of selenium (Se), Se and hydrogen (H2), hydrogen selenide (H2Se), sulfur (S), S and H2, hydrogen sulfide (H2S), or combinations thereof. The metal precursors in the alkali metal-doped first intermediate film are transformed, and an alkali metal-doped chalcogenide layer is formed.
US08945977B2 Interconnection method for a micro-imaging device
A method for producing an opto-microelectronic micro-imaging device includes a step of forming a first functional part on the base of a first substrate, a base layer, and first electric connection pad. The first functional part is transferred onto a second substrate. The first substrate is thinned until the base layer is reached. A second functional part is formed on the base layer. One via is connected to the first electric connection pad and through the first functional part. The step of forming the second functional part includes connecting the via with the second electric connection pad.
US08945974B2 Method of manufacturing organic light-emitting display device using an organic layer deposition apparatus
A method of manufacturing an organic light-emitting display device includes: fixing a substrate onto an electrostatic chuck; combining the electrostatic chuck with a chuck moving member; moving the electrostatic chuck along a guide member into a chamber by using the chuck moving member; and depositing an organic layer on the substrate while moving the substrate with respect to an organic layer deposition assembly arranged in the chamber, the chuck moving member being moved along the guide member by an association of a chain unit and a hook unit, and the substrate being spaced apart from the organic layer deposition assembly.
US08945973B2 Method of manufacturing backside illuminated active pixel sensor array
A backside-illuminated active pixel sensor array in which crosstalk between adjacent pixels is prevented, a method of manufacturing the backside-illuminated active pixel sensor array, and a backside-illuminated image sensor including the backside-illuminated active pixel sensor array are provided. The backside-illuminated active pixel sensor array includes a semiconductor substrate of a first conductive type that comprises a front surface and a rear surface, light-receiving devices for generating charges in response to light incident via the rear surface, and one or more pixel isolating layers for forming boundaries between pixels by being disposed between the adjacent light-receiving devices, a wiring layer disposed on the front surface of the semiconductor substrate, and a light filter layer disposed on the rear surface of the semiconductor substrate, wherein a thickness of the one or more pixel isolating layers decreases from a point in the semiconductor substrate toward the rear surface.
US08945972B2 Layered system for producing a solar cell on a metal substrate, method for producing said layered system
The invention relates to a layered system for producing a solar cell on a metal substrate and to a method of producing the layered system.
US08945971B2 Wafer warpage reduction
The present disclosure relates a method to mitigate wafer warpage in advanced technology manufacturing processes due to crystallization of one or more amorphous layers with asymmetrical front-surface and back-surface layer thicknesses. After deposition of one or more layers of amorphous material on a front-surface and a back-surface of the wafer in a furnace tool, the front-surface layers are patterned which thins a front layer thickness. Downstream thermal processing performed at a temperature which exceeds a crystallization threshold of the amorphous material will result in asymmetric stress between the front and back surfaces due to the asymmetrical layer thicknesses. To mitigate this effect, the amount of warpage as a function of the difference in asymmetrical layer thickness may be determined such that a front-surface deposition tool may be utilized in conjunction with the furnace tool to reduce the difference in front-surface and back-surface layer thicknesses. Other methods are also disclosed.
US08945969B2 Internal electrical contact for enclosed MEMS devices
A method of fabricating electrical connections in an integrated MEMS device is disclosed. The method comprises forming a MEMS wafer. Forming a MEMS wafer includes forming one cavity in a first semiconductor layer, bonding the first semiconductor layer to a second semiconductor layer with a dielectric layer disposed between the first semiconductor layer and the second semiconductor layer, and etching at least one via through the second semiconductor layer and the dielectric layer and depositing a conductive material on the second semiconductor layer and filling the at least one via. Forming a MEMS wafer also includes patterning and etching the conductive material to form one standoff and depositing a germanium layer on the conductive material, patterning and etching the germanium layer, and patterning and etching the second semiconductor layer to define one MEMS structure. The method also includes bonding the MEMS wafer to a base substrate.
US08945968B2 Compliant micro device transfer head with integrated electrode leads
A compliant micro device transfer head and head array are disclosed. In an embodiment a micro device transfer head includes a spring arm having integrated electrode leads that is deflectable into a space between a base substrate and the spring arm.
US08945967B2 Photosensitive imaging device and method for forming semiconductor device
A photosensitive imaging device and a method for forming a semiconductor device are provided. The method includes: providing a first device layer formed on a first substrate, wherein a conductive top bonding pad layer is formed on the first device layer; providing a continuous second device layer formed on a second substrate, wherein a continuous conductive adhesion layer is formed on the continuous second device layer; bonding the first device layer with the second device layer, where the top bonding pad layer on the first device layer is directly connected with the conductive continuous adhesion layer on the continuous second device layer; removing the second substrate; selectively etching the continuous second device and the continuous conductive adhesion layer to form a groove array; and filling up the groove array with an insulation material to form a plurality of second devices. Alignment accuracy may be improved.
US08945965B2 Method for producing a group III nitride semiconductor light-emitting device
The present invention provides a Group III nitride semiconductor light-emitting device exhibiting improved light extraction performance. In the production method, a p cladding layer of p-AlGaN is formed by the MOCVD method on a light-emitting layer at a pressure of 30 kPa and with an Mg concentration of 1.5×1020/cm3. A plurality of regions with a nitrogen polarity is formed in the crystals with a Group III element polarity, and thus the p cladding layer has a hexagonal columnar concave and convex configuration on the surface thereof. Subsequently, a p contact layer of GaN is formed by the MOCVD method, in a film along the concave and convex configuration on the p cladding layer.
US08945963B2 Optical device processing method
An optical device processing method including: a groove forming step of forming a plurality of grooves on a front side of a sapphire substrate; a film forming step of forming an epitaxial film on the front side of the sapphire substrate after performing the groove forming step, thereby forming a plurality of optical devices and a plurality of crossing division lines for partitioning the optical devices; and a dividing step of dividing the sapphire substrate with the epitaxial film along the division lines after performing the film forming step, thereby obtaining a plurality of individual optical device chips.
US08945961B2 Organic light-emitting display device and method of manufacturing the same
In an organic light-emitting display device and a method of manufacturing the organic light-emitting display device, the method includes forming thin film transistors (TFTs) on a substrate; and forming organic light emitting diodes (OLEDs), each of the OLEDs including a first electrode having a portion exposed by a pixel defining layer (PDL) on the TFTs, an organic layer on the exposed portion of the first electrode and including an emission layer (EML) configured to emit light having a respective one of a plurality of colors, and a second electrode on the organic layer. The EML is formed in each of a sub-pixel region with one color and other sub-pixel regions with other colors that are formed by forming openings in the PDL. A solution supply unit for sub-pixel region that communicates with the sub-pixel region with one color is formed in the sub-pixel region with one color.
US08945960B2 Optical device processing method
An optical device wafer has a plurality of optical devices formed on a front side and a plurality of crossing division lines for partitioning the optical devices. Each optical device has electrodes formed on the front side. A processing method includes: forming a groove on the front side of the wafer along each division line, the groove having a depth reaching a finished thickness; of forming a nonconductive reflective film on the front side of the wafer to thereby form the reflective film on at least the side surfaces of the groove; removing the reflective film formed on the electrodes to thereby expose the electrodes; and grinding a back side of the wafer to thereby reduce the thickness to the finished thickness until the groove is exposed to the back side of the wafer to divide the wafer into individual optical device chips.
US08945956B2 Metrology test structures in test dies
Test dies having metrology test structures and methods of manufacture are disclosed. The method includes forming one or more metrology test structures in a test die that are identical to one or more structures formed in an adjacent product chip.
US08945951B2 Lead frame and manufacturing method thereof
Disclosed are a lead frame and a method for manufacturing the same. The lead frame includes a copper substrate and a rough copper layer having surface roughness of 110 nm to 300 nm on a surface of the copper substrate.
US08945946B2 Sensor element and detection method of magnetic particles using this element, and detection method of target substance
A sensor device is configured by using a sensor element including functions as a magnetic field sensor and capable of generating the magnetic field for collecting magnetic particles on a sensor surface by the application of the current. As a result, a sensor device can be provided in which the magnetic particles serving as a label can be effectively collected on the sensor, and at the same time, the influence given to the sensor by the magnetic field for collecting the magnetic particles can be reduced.
US08945945B1 Sample collection and analysis
Management of the health status of an animal colony using a plurality of blood collection cards and the analysis of dried blood from members of the colony that has been collected on the cards. Members of the colony may be removed from the colony as a result of the analysis.
US08945942B2 Stabilization of bio-sensors for in vivo applications
The present invention relates to the use of preparations for stabilizing isolated proteins. In particular, the use of such a preparation for stabilizing receptors in biochemical sensors is disclosed. The invention in addition relates to biochemical sensors containing such preparations.
US08945940B2 Mass- and property-tuned variable mass labeling reagents and analytical methods for simultaneous peptide sequencing and multiplexed protein quantification using thereof
The present invention provides variable mass labeling reagents, a set of the variable mass labeling reagents, and a multiplexed set of variable mass labeling reagents.
US08945935B2 Diagnosing, prognosing and monitoring multiple sclerosis
The present invention provides a system and method for diagnosing, monitoring or prognosing Multiple Sclerosis at different stages as well as affording the prediction of disease activity and response to a treatment regimen, using at least one sensor comprising carbon nanotubes or metal nanoparticles, each coated with various organic coatings in conjunction with a pattern recognition algorithm.
US08945934B2 Potentiometric titration method for measuring concentration of acid mixture of aluminum etchant
The present invention provides a potentiometric titration method for measuring concentration of acid mixture of aluminum etchant, which prepares identified potassium hydroxide-ethanol solution or sodium hydroxide-ethanol solution as a titrant and uses a monohydric alcohol and a diol as an anhydrous medium for the acid mixture of aluminum etchant to carry out titration of the acid mixture of aluminum etchant so as to realize measurement of concentration of each acid contained in the acid mixture of aluminum etchant through a one-stage process of potentiometric titration thereby reducing the complication of operation of inspection and uncertainty of inspection result and achieving the purposes of carrying out inspections with high precision and high performance. The method can efficiently and accurately measure the concentrations of nitric acid, phosphoric acid, and acetic acid contained in the acid mixture of aluminum etchant.
US08945933B2 Liquid chromatography-mass spectrometry methods for multiplexed detection and quantitation of free amino acids
The present invention provides liquid chromatography-mass spectrometry methods and kits for the specific, sensitive and rapid detection as well as quantitation of free amino acids in samples following High Pressure Liquid Chromatography (HPLC) separation.
US08945931B2 Method and kits to detect beryllium by fluorescence
A low-cost practical method of determining beryllium or a beryllium compound thereof in a sample is disclosed by measuring fluorescence. This method discloses optical filters for use with low cost fluorometers which may be used to quantitatively determine the presence of beryllium. This method may be extended to estimate particle size distribution for particles comprising Beryllium. A method is also disclosed to store solutions for extended period of time so that these materials are stable during transportation and in the labs.
US08945928B2 Microarray system with improved sequence specificity
The invention provides a novel array method for nucleic acid sequence detection with improved specificity which allows for detection of genetic variation, from simple SNPs (where the variation occurs at a fixed position and is of limited allelic number) to more complex sequence variation patterns (such as with multigene families or multiple genetic strains of an organism where the sequence variation between the individual members is neither fixed nor consistent). The array is comprised of short, synthetic oligonucleotide probes attached to a solid surface which are hybridized to single-stranded targets. Single stranded targets can be produced using a method that employs primers modified on the 5′ end to prohibit degradation by a 5′-exonuclease that is introduced to degrade the unprotected strand. The invention further provides for printing buffers/solutions for the immobilization of oligonucleotide probes to an array surface. The invention also provides hybridization and wash buffers and conditions to maximize hybridization specificity and signal intensity, and reduce hybridization times.
US08945921B2 Modulating the production of neurons and/or oligodendrocytes from white matter progenitor cells
The present invention relates to a method of modulating production of neurons and/or oligodendrocytes from neural progenitor cells of human white matter and to a method of treating a subject for a condition modulated by underproduction of oligodendrocytes from human white matter. Both of these methods involve administering an agonist or antagonist of one or more molecules set forth in Tables 1 and/or 2 to the neural progenitor cells. Also disclosed is a method of using an inhibitor of sterol synthesis to differentiate oligodendrocyte progenitor cells to oligodendrocytes.
US08945917B2 Enhanced surface area conico-cylindrical flask (ES-CCF) for biofilm cultivation
A novel enhanced surface area conico-cylindrical flask (ES-CCF) providing increased surface area by virtue of its' inner arrangement and useful in routine small-scale studies of bioactives production by any biofilm-forming marine as well as terrestrial microorganisms. Compared to corresponding Erlenmeyer flask of similar volume the ES-CCF provides more than 80% additional surface for biofilm attachment and growth. The ES-CCF does not require steam sterilization and is durable as the device is constructed of polymethyl methacrylate or any other such hydrophobic material and offers possibility of altering the nature of the growth surface (hydrophilic and hydrophobic). The ES-CCF also provides external aeration like a bioreactor, thus increasing the versatility of applications. Further, the device can be operated as a cylindrical flask, that is without the inner arrangement.
US08945916B2 Device and method for photosynthetic culture
A device and system for growing of a photosynthetic culture is provided which employs one or a plurality of vertically disposed photopanels having interior cavities configured for holding liquid and the photosynthetic culture such as algae. Interior surfaces are enhanced in size by projections defined by deformation in sidewalls of the photopanels. The projections communicate between the sidewalls also providing structural integrity to the photopanel and allowing for thinner sidewalls and increased light transmission therethrough. The system may employ a support rack and pivotal mount to each such photopanel to allow positioning adjacent to each other in rows. Pivoting during different lighting conditions afforded the racked photopanels provides a manner to reduce light blockage to individual photo panels from adjacent photopanels.
US08945914B1 Devices, systems, and methods for conducting sandwich assays using sedimentation
Embodiments of the present invention are directed toward devices, systems, and method for conducting sandwich assays using sedimentation. In one example, a method includes generating complexes on a plurality of beads in a fluid sample, individual ones of the complexes comprising a capture agent, a target analyte, and a labeling agent. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a density lower than a density of the beads and higher than a density of the fluid sample, and wherein the transporting occurs, at least in part, by sedimentation. Signal may be detected from the labeling agents of the complexes.
US08945913B2 Kits, compositions and methods for detecting a biological condition
The present invention provides kits, apparatus and methods for determining a biological condition in a mammalian subject, the method includes incubating a specimen from a patient with at least one composition in a kit for a predetermined period of time to form at least one reaction product, when the subject has said biological condition, and receiving an indication of the at least one reaction product responsive to at least one reporter element in the kit thereby providing the indication of the biological condition in the subject.
US08945905B2 Cat litter formulation
A waste capture media formulation comprising a bacteria package. The bacteria package does not include a bacteria that produces a urease enzyme. The formulation further comprises an absorbent media, an odor suppressant, a binding agent, a mineral source, a masking agent, and an aqueous surfactant.
US08945904B2 Influenza virus reassortment
Methods for producing reassortant viruses are provided wherein the transcription and/or translation of the hemagglutinin and/or neuraminidase genes are suppressed.
US08945903B2 Cellobiohydrolase variants
The present invention relates to cellobiohydrolase variants having improved thermostability in comparison to wild-type CBH2a.
US08945898B2 Recombinant host cell with deficiency in non-ribosomal peptide synthase production
The present invention relates to a method for the production of a compound of interest by microbial fermentation, wherein the microbial host cell used has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The present invention further relates to a microbial host cell that has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The invention further relates to a compound of interest.
US08945890B2 Method for producing monoterpene and monoterpinoid compounds and use thereof
In various embodiments, the present disclosure provides a method and enzyme for forming various compounds, such as monoterpenes and monoterpenoid compounds. In a specific example, the present disclosure provides a method for producing one or more of (−)-ipsdienol, (−)-ipsenol, ipsenone, and ipsdienone. The present disclosure also provides methods of using compounds formed from the disclosed method and enzyme.
US08945880B2 Thermal cycling by positioning relative to fixed-temperature heat source
The thermal cycling system for performing a biological reaction at two or more different temperatures comprises: a) a heat source for setting at a fixed temperature; b) a reaction vessel containing material upon which the biological reaction is to be performed; c) mechanically-operable structure for altering the relative position of the heat source and the reaction vessel so that reaction vessel first achieves and maintains a desired first temperature in the reaction vessel for starting the carrying out of the biological reaction, and then for altering the relative position of the heat source and the reaction vessel so that the reaction vessel then achieves and maintains a second temperature for continuing the carrying out of the biological reaction on the biological material, and d) temperature-sensing structure operatively associated with the reaction vessel for controlling the altering of the relative position of the heat source and the reaction vessel so that the reaction vessel achieves and maintains the desired second temperature in the reaction vessel.
US08945877B2 Polynucleotides encoding BMP-ALK3 antagonists
In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density and strength. In certain embodiments, the present invention provides ALK3 polypeptides, including ALK3-Fc fusion proteins.
US08945864B2 Method of determining 1,5-anhydroglucitol, and reagent composition for determining 1,5-anhydroglucitol
The object of the present invention is to provide a method of determining 1,5-anhydroglucitol, including using (a) a protein which consists of the amino acid sequence of SEQ ID NO: 2; (b) a protein which consists of an amino acid sequence having deletion, substitution and/or addition of one or more amino acid residues in the amino acid sequence of SEQ ID NO: 2 and which has sorbose dehydrogenase activity; or (c) a protein which consists of an amino acid sequence having a homology of at least 60% with the amino acid sequence of SEQ ID NO: 2 and which has sorbose dehydrogenase activity.
US08945861B2 Methods for isotopically labeling biomolecules using mammalian cell-free extracts
Methods for producing an isotope-labeled mammalian, including a human, biomolecule, such as polypeptides and proteins, in a cell-free protein synthesis system. A biomolecule standard is produced having at least one isotope different in abundance than that of the naturally occurring isotopes in the biomolecule. Methods for quantifying biomolecules standards expressed using mammalian cell-free extracts are disclosed. Methods for producing such standards, kits, systems and reagents, relating to the use of isotope-labeled biomolecule as quantification standards in mass spectrometric and nuclear magnetic resonance analysis.
US08945858B2 Methods and compositions for treating neurodegenerative disorders and alzheimer's disease and improving normal memory
The disclosure relates generally to neurodegenerative disorders and more specifically to a group of presenilin/G-protein/c-src binding polypeptides and methods of use for modulating signaling and progression of Alzheimer's disease.
US08945850B2 Detection, identification and differentiation of Staphylococcus using a hybridization assay
The present invention relates to a method for the specific detection and/or identification of Staphylococcus species, in particular Staphylococcus aureus, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Staphylococcus species, in particular of S. aureus, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Staphylococcus species in a sample.
US08945849B2 Method for diagnosing esophageal cancer
This invention relates to a composition, kit, or DNA chip for use in diagnosis of esophageal cancer, which comprises a plurality of polynucleotides selected from the group consisting of polynucleotides whose expression levels are varied in esophageal cancer tissues obtained from esophageal cancer patients when compared with cancer-free esophageal tissues obtained from esophageal cancer patients, mutants thereof, and fragments thereof, and to a method for detecting esophageal cancer using the composition, kit, or DNA chip.
US08945846B2 Mutations in the LNK gene in patients with myeloproliferative neoplasms and other hematolymphoid malignancies
Aspects of the present invention include methods, compositions and kits for classifying a subject as having or being predisposed to a hematolymphoid neoplasm or malignancy if they harbor a mutation in the LNK gene. Aspects of the present invention also include screening for candidate agents for treating LNK mutation-based hematolymphoid neoplasms or malignancies in cell-based and cell free assays as well as therapeutic compositions for treating a LNK-mutant based hematolymphoid disorder. Also provided are compositions, systems, kits and computer program products that find use in practicing the subject methods.
US08945842B2 Assay for Trichomonas vaginalis by amplification and detection of Trichomonas vaginalis AP65-1 gene
A region of the Trichomonas vaginalis AP65-1 gene has been identified which is useful for performing amplification assays to determine specifically whether T. vaginalis is present in the sample being tested. Oligonucleotides useful for performing thermal Strand Displacement Assay (tSDA) reactions on this gene are disclosed. The disclosed oligonucleotides can be used in an assay which is specific for multiple strains of T. vaginalis and which does not show cross reactivity with the genomes of other microorganisms or with human DNA.
US08945840B2 Methods for the selection of aptamers
The present invention generally relates to methods for selecting aptamers. More specifically, the invention provides methods for the selection of at least one aptamer for use in combination with another epitope binding agent such as another aptamer, an antibody, or a double stranded nucleic acid. The invention also encompasses methods for simultaneously selecting at least two aptamers that each recognize distinct epitopes on a target molecule.
US08945837B2 Sterilization indicator including a simplified genetically engineered biological indicator
A sterilization indicator, including a first compartment containing a genetically engineered biological indicator, and a second compartment containing an enzyme substrate, the second compartment adapted to maintain the enzyme substrate separate from the biological indicator during sterilization, and to permit the enzyme substrate to contact the biological indicator after the biological indicator has been exposed to the sterilization medium; in which the genetically engineered biological indicator comprises at least one test organism and at least one reporter gene suitable for producing an indicator enzyme, the reporter gene being taken up by the test organism; and the test organism is free of any active or activatable repressor gene that would inhibit expression of the reporter gene if present in the test organism or sterilization indicator, and the indicator enzyme and the enzyme substrate are selected such that enzymatic action of the indicator enzyme upon the enzyme substrate yields a detectable signal.
US08945836B2 Multicomponent nucleic acid enzymes and methods for their use
The present invention relates to Multicomponent Nucleic Acid Enzymes (MNAzymes) and methods for their use. MNAzymes comprise two or more oligonucleotide components which self-assemble in the presence of one or more MNAzyme assembly facilitator molecules to form a catalytically active structure. Compositions for making MNAzymes, and collections of MNAzymes are provided. Also provided are methods for using MNAzymes for the detection, identification and/or quantification of one or more targets. The methods can be practiced in solution-based assays or in assays where one or more reaction components are attached to a support structure. The methods allow for multiplexing the MNAzyme detection to detect multiple targets in a single reaction. Also provided are kits for making the compositions, and for practicing the methods provided herein.
US08945830B2 Multiplexed analyses of test samples
The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule. An aptamer affinity complex that includes an aptamer bound to its target molecule is allowed to form. If the test sample contains the target molecule, an aptamer affinity complex will generally form in the test sample. The aptamer affinity complex is optionally converted to an aptamer covalent complex that includes an aptamer covalently bound to its target molecule. The aptamer affinity complex (or optional aptamer covalent complex) can then be detected and/or quantified using any of a variety of methods known to one skilled in the art, including using a solid support, using mass spectrometry, and using quantitative polymerase chain reaction (Q-PCR).
US08945828B2 Method of identifying fetal antigens or cell surface markers using phage display technology
The present application relates to methods for identification of foetal cells and generation and isolation of binding members recognizing foetal cells. The methods of the invention may further be used for other purposes relating to characterization of biological samples and biological antigens. The methods are characterized by the applicability in situations where the interesting objects are present in a limited amount, or where the interesting objects are intermixed with other material, thus the methods are suitable for use in situations where the ratio of the interesting material compared to other material is low.
US08945827B2 Serological methods and diagnostic tests for syphilis antibodies
A non-treponemal diagnostic test for syphilis infection includes initially dissolving cholesterol in an organic solvent and further diluting the dissolved cholesterol in an ethanol solution comprising cardiolipin and lecithin, permitting a volume of the antigen solution to evaporate in place within a container, rinsing the coated container with buffered saline, stabilizing the antigen coating by overcoating the antigen coating with an inert protein dissolved in buffered saline, decanting the overcoat solution, air-drying the container, and sealing the container in vapor-proof pouches with desiccant, providing an enzyme-labeled conjugate component of a syphilis infection test that is formulated to be compatible with a lipid nature of the cholesterol, the cardiolipin, and the lecithin VDRL antigens, providing a sample diluent that is formulated to be compatible with the lipid nature of the VDRL antigens, and providing a wash fluid that is formulated to be compatible with the lipid nature of the VDRL antigens.
US08945824B2 Method of determining hypoxia
A method of determining hypoxia in fetal scalp blood sampled during labor comprises the determination of total lactate dehydrogenase (LDH) in plasma obtained from the sample. The method can comprise the additional determination of K, Mg, Ca, AST, ALT, lactate in the plasma and/or blood. Increased values of one or more of LDH, Mg, Ca, AST, ALT, lactate are indicative of hypoxia in the fetus. Also disclosed is the use of a plasma separation apparatus in the method.
US08945823B2 Compositions and methods for tissue preservation
Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions.
US08945821B2 Method for patterning flexible substrate
The invention provides a method for patterning a flexible substrate. The method for patterning a flexible substrate includes providing a carrier substrate. A release layer is formed on the carrier substrate. A flexible substrate film is formed on the release layer. A plurality of UV blocking mask patterns is formed covering various portions of the flexible substrate film and the release layer. A UV lighting process is performed to expose the flexible substrate film and the release layer not covered by the UV blocking mask patterns, to a UV light. A debonding step is performed so that the various portions of the flexible substrate film directly above the various portions of the release layer, which were not exposed to the UV light, are separated from the carrier substrate.
US08945817B2 Process for producing chip
A process for producing a chip in which plural ejection orifice arrays are arranged including conducting reduction projection exposure plural times to a wafer having a substrate and a photosensitive resin layer formed thereon while relatively moving positions of the wafer and a reticle to form ejection orifice array patterns in the resin layer, developing the patterns to form ejection orifice arrays in the resin layer, and dividing the wafer to form plural chips in which the plural ejection orifice arrays are arranged. The exposure is conducted once to form in the resin layer a first ejection orifice array pattern corresponding to partial ejection orifice arrays in an arranging direction thereof in one chip, a second ejection orifice array pattern corresponding to all ejection orifice arrays in one chip and a third ejection orifice array pattern corresponding to partial ejection orifice arrays in an arranging direction thereof in one chip.
US08945815B2 Alkaline soluble resin and light sensible resin composition comprising same and use thereof
An embodiment of the invention discloses an alkaline soluble resin and a method for preparing the same. The chemical formula of this alkaline soluble resin is shown in Formula I: wherein a is an integer of 1 to 5, b is an integer of 1 to 5, c is an integer of 1 to 10, d is an integer of 1 to 10, m is an integer of 1 to 30, n is an integer of 1 to 10, R is hydrogen, alkyl, alkoxy or acrylate; the alkaline soluble resin has a weight-average molecular weight of 3,500-35,000. The invention also discloses a light sensible resin composition comprising the alkaline soluble resin, as well as a colored photoresist for color filters comprising the aforementioned light sensible resin composition and a display element comprising this colored photoresist.
US08945814B2 Acid generators and photoresists comprising same
Acid generator compounds are provided that are particularly useful as photoresist composition components. Preferred acid generators include cyclic sulfonium compounds that comprise a covalently linked acid-labile group.
US08945811B2 Miniaturized microparticles
A system and method for forming encoded microparticles is described. One embodiment includes an encoded microparticle, the microparticle comprising a plurality of segments aligned along an axis, wherein the plurality of segments define a code for the microparticle; and an outer cuboid encapsulating the plurality of segments, wherein the plurality of segments are detectable through the outer cuboid.
US08945807B2 Blends of fullerene derivatives, and uses thereof in electronic devices
Disclosed are compositions of mixed fullerene derivatives with utility in organic semiconductors, and methods of making and using such compositions. In certain embodiments, the present invention relates to compositions of mixed fullerene derivatives further comprising one or more additional fullerene-based components within specified ranges. In certain other embodiments, the invention relates to methods of producing mixed fullerene derivatives of a specific composition from mixed fullerene starting materials, or pure fullerene derivatives of a specific composition from mixed fullerene derivatives. In yet other embodiments, the invention relates to semiconductors and devices comprising a composition of the invention.
US08945805B2 Magnetic carrier and two-components developer
The present invention provides an image of high image quality by using a magnetic carrier coated with a novel coating resin composition. Further, the present invention stably provides a good image which is hardly influenced by environmental fluctuation and long-term use and has a superior stability of a charging amount when left to stand especially under high temperature and high humidity environments. The present invention also provides a magnetic carrier characterized in that a carrier core surface is coated with a copolymer containing at least, as copolymerization components, an acrylic monomer having a specific structure and an acrylic macromonomer having a specific structure.
US08945802B2 Flare-measuring mask, flare-measuring method, and exposure method
A method for measuring flare information of a projection optical system includes arranging, on an object plane of the projection optical system, a sectoral pattern surrounded by a first side, a second side which is inclined at a predetermined angle with respect to the first side, and an inner diameter portion and an outer diameter portion which connect both ends of the first side and both ends of the second side; projecting an image of the sectoral pattern via the projection optical system; and determining the flare information based on a light amount of the image of the sectoral pattern and a light amount provided at a position away from the image. With the flare measuring method, it is possible to correctly measure the flare information in an arbitrary angle range of the sectoral pattern.
US08945801B2 Method for creating mask data, program, information processing apparatus, and method for manufacturing mask
Data regarding a first corrected patterns on a single cell corrected such that an evaluation value of a pattern formed on a substrate after an image of a pattern of the single cell is projected onto a resist on the substrate and the resist is developed is obtained for each of a plurality of cells, a first evaluation value obtained by evaluating a projected image of the first corrected pattern on the single cell generated by the projection system is obtained for each of the cells, a second evaluation value obtained by, when the cells are arranged adjacent to one another, evaluating the projected images of the first corrected patterns on the cells is calculated, and creating a second corrected pattern by correcting the first corrected patterns on the cells arranged adjacent to one another such that the second evaluation value becomes close to the first evaluation value.
US08945799B2 Pellicle and mask adhesive agent for use in same
A pellicle which has a mask adhesive layer that can be plastic-deformed readily particularly at a temperature at which exposure to light is carried out, rarely provides a residue of an adhesive agent upon the removal of the mask adhesive layer from a mask and has good handling properties, and which can prevent the position gap of a pattern. The pellicle comprises a pellicle frame, a pellicle membrane and a mask adhesive layer containing a mask adhesive agent. The mask adhesive agent comprises 100 parts by mass of a thermoplastic elastomer (A) having a tan δ peak temperature of −20 to 30 DEG C and 20 to 150 parts by mass of an adhesiveness-imparting resin (B).
US08945795B2 Methods and apparatuses for continuous manufacturing of fuel cells
An apparatus and method for substantially continuously manufacturing fuel cells are provided. Each cell generates electrical power from reactions of reactants therein. Each cell comprises component parts assembled and/or laminated together in a stacked configuration. The apparatus includes an assembly zone for receiving rolls of material and/or pre-formed component parts for fabricating the cells, and assembly devices for, commencing from a starting layer, progressively assembling and/or laminating layers of material and/or pre-formed component parts from the rolls to the starting layer to manufacture the fuel cells, a testing zone for applying a test procedure to the cells to identify functional cells thereof or parts thereof, the testing zone also including a fuel-cell repair function for recycling fuel cells, or parts thereof, found to be to be defective in response to applying the test procedure, a separating zone for mutually separating the functional cells into individual fuel cells, parts thereof or groups of such fuel cells, and a stacking zone for mutually assembling the functional fuel cells or the groups of such functional cells into stacks of such fuel cells to manufacture fuel cell packs.
US08945787B2 Fuel-using system comprising electromagnetic force adjusting unit
An electromagnetic main stop valve which is opened by an electromagnetic force of a solenoid with energization of a valve body in a valve-closing direction by energizing unit is provided in a hydrogen tank. A current sensor and the accelerator opening-degree sensor for detecting a use gas flow rate in a fuel cell stack are provided. A pressure sensor for detecting a pressure in the hydrogen tank is provided. The control device sequentially sets the electromagnetic force of the solenoid so that a valve-opening amount is such an amount as to supply a use gas flow rate to the fuel cell stack based on detection values of the current sensor or the accelerator opening-degree sensor, and the pressure sensor. When the flow rate of hydrogen gas flowing into a gas supply path increases due to a hydrogen gas leak, the main stop valve is automatically closed.
US08945781B2 Non-aqueous electrolyte for secondary battery and non-aqueous electrolyte secondary battery
The present invention provides a non-aqueous electrolyte secondary battery wherein a reaction between a non-aqueous electrolyte and an electrode is suppressed and decrease in battery capacity under high temperature is restricted, so that long time excellent battery characteristics can be obtained. A non-aqueous solvent of the non-aqueous electrolyte contains: chain fluorinated carboxylic acid ester represented by the formula R1-CH2—COO—R2 where R1 represents hydrogen or alkyl group and R2 represents alkyl group and the sum of the carbon numbers of R1 and R2 is 3 or less, and in the case that R1 is hydrogen, at least one part of hydrogen in R2 is replaced with fluorine, and, in the case that R1 is alkyl group, at least one part of hydrogen in R1 and/or R2 is replaced with fluorine; and a film forming chemical compound decomposed in the range of +1.0 to 3.0 V based on an equilibrium potential between metal lithium and lithium ion.
US08945780B2 Nonaqueous electrolyte and nonaqueous electrolyte battery
A nonaqueous electrolyte includes: a nonaqueous solvent containing 0.1% by volume or more and not more than 50% by volume of at least one member selected from the group consisting of a halogen element-containing chain carbonate represented by the following formula (1) and a halogen element-containing cyclic carbonate represented by the following formula (2); and an electrolyte salt containing a compound represented by the following formula (3) in an amount of 0.001 moles/L or more and not more than 0.5 moles/L relative to the nonaqueous solvent
US08945779B2 Solid electrolyte material, lithium battery, and method of producing solid electrolyte material
A main object of the present invention is to provide a solid electrolyte material having excellent Li ion conductivity. To attain the object, the present invention provides a solid electrolyte material represented by a general formula: Lix(La1-aM1a)y(Ti1-bM2b)zOδ, characterized in that “x”, “y”, and “z” satisfy relations of x+y+z=1, 0.652≦x/(x+y+z)≦0.753, and 0.167≦y/(y+z)≦0.232; “a” is 0≦a≦1; “b” is 0≦b≦1; “δ” is 0.8≦δ≦1.2; “M1” is at least one selected from the group consisting of Sr, Na, Nd, Pr, Sm, Gd, Dy, Y, Eu, Tb, and Ba; and “M2” is at least one selected from the group consisting of Mg, W, Mn, Al, Ge, Ru, Nb, Ta, Co, Zr, Hf, Fe, Cr, and Ga.
US08945772B2 Power storage device
A power storage device a positive electrode including a positive electrode active material layer and a negative electrode including a negative electrode active material layer. The positive electrode active material layer includes a plurality of particles of x[Li2MnO3]-(1−x)[LiCo1/3Mn1/3Ni1/3O2] (obtained by assigning 0.5 to x, for example) which is a positive electrode active material, and multilayer graphene with which the plurality of particles of the positive electrode active material are at least partly connected to each other. In the multilayer graphene, a plurality of graphenes are stacked in a layered manner. The graphene contains a six-membered ring composed of carbon atoms, a poly-membered ring which is a seven or more-membered ring composed of carbon atoms, and an oxygen atom bonded to one or more of the carbon atoms in the six-membered ring and the poly-membered ring, which is a seven or more-membered ring.
US08945770B2 Cathode active material exhibiting improved property in high voltage
Disclosed herein is a cathode active material including a lithium transition metal oxide based on at least one transition metal selected from a group consisting of Ni, Mn and Co. The lithium transition metal oxide contains fluorine, and most of the fluorine is present on a surface of the lithium transition metal oxide, and at least one metal selected from a group consisting of Mg, Ti, Zr, Al and Fe as well as sulfur (S) are further contained in the lithium transition metal oxide.
US08945769B2 Accumulator material and accumulator device
An electricity storage device including a positive electrode 31, a negative electrode 32, and an electrolytic solution 29 located between the positive electrode and the negative electrode. At least one of the positive electrode 31 and the negative electrode 32 contains an electricity storage material containing a polymerization product having a tetrachalcogenofulvalene structure in a repeat unit of a main chain.
US08945762B2 Battery
A negative lower gasket has a rib disposed along the outer periphery of a flat portion having a base of a negative current collector disposed thereat. The height of the rib is set to be more than a thickness of the negative lower gasket. The rib may be disposed only at a portion corresponding to a position where legs project from the base of the negative current collector at the outer periphery of the flat portion.
US08945759B2 Rechargeable battery
A battery including an electrode assembly including a positive electrode, a negative electrode, and a separator therebetween; a case housing the electrode assembly; a cap plate coupled to the case; a collector plate coupled to the electrode assembly; and a terminal coupled to the collector plate and passing through the cap plate, wherein the terminal includes a terminal protrusion and a bottom protrusion, the collector plate includes an electrode region coupled to the electrode assembly and a terminal region coupled to the terminal, the terminal region including a combining hole passing therethrough, the combining hole having a noncircular shape, and the bottom protrusion of the terminal has an interengaging, matching shape relative to the combining hole, passes through the combining hole of the collector plate, and is welded to a lower surface of the collector plate.
US08945758B2 Secondary battery having cap plate assembly with short circuit safety member
A secondary battery includes an electrode assembly; a collecting plate electrically coupled to the electrode assembly and having a short circuit hole; a short circuit member comprising a metal can, wherein the metal can is in the short circuit hole; a case accommodating the electrode assembly and the collecting plate and having an opening; and a cap assembly comprising a cap plate sealing the opening of the case.
US08945748B2 Battery pack
The invention relates to a battery pack (2) for supplying an electrical appliance or an electromobile, especially a power tool, with power. Said battery pack comprises a plurality of battery cells (4) and at least one heat compensation element (18) interposed between neighboring battery cells (4). The invention is characterized in that the heat compensation element (18) consists of a plastic material.
US08945747B2 Battery cell having an attachment structure and vehicle battery module
In a longitudinal battery cell for a vehicle battery module, the battery cell includes a first end and an opposite second end with respect to a longitudinal axis of the battery cell, and a lateral surface extending from the first end to the second end. The battery cell includes an attachment structure extending in an outward direction from the lateral surface at the second end for coupling the battery cell to the battery module.
US08945745B2 Battery device, electronic apparatus, and battery system
Disclosed is a battery device including a battery enclosure incorporating a battery cell. The battery device further includes an output terminal that outputs power of the battery cell. The battery enclosure includes a first surface, a second surface, a first step surface, a second step surface, a first engaging portion, a second engaging portion, a first groove, and a second groove formed in the second step surface and the second engaging portion, and a recess is provided in at least one of the first step surface and the second step surface.
US08945744B2 Electrode assembly having stepped portion, as well as battery cell, battery pack, and device including the electrode assembly
There is provided an electrode assembly. The electrode assembly includes a stack of unit cells respectively including at least one negative electrode and at least one positive electrode, alternately stacked, wherein at least one separator is placed on each of both sides of the electrodes, and at least one of the unit cells has an area different from that of an adjacent unit cell to form at least one stepped portion on the electrode assembly. In addition, there are also provided a battery cell, a battery pack, and a device that include the electrode assembly.
US08945741B2 Battery pack including a guide disposed on an inner surface of a case
A cover 1b of a battery pack case has an intake port and an exhaust port 31. With in the battery pack case, battery accommodation sections respectively accommodate battery modules and a junction box accommodation section. A supply flow path and an exhaust flow path are provided at ends of each of the battery accommodation section. A guide is provided between the cover and the battery modules accommodated in the battery accommodation portions. The guide and a lower surface of the cover define a distribution flow path. The air introduced from the intake port flows to the exhaust port through the distribution flow path, supply flow paths, clearances between battery cells, exhaust flow paths, and exhaust port. The battery cells are efficiently cooled.
US08945739B2 Fluidic architecture for metal-halogen flow battery
A metal-halogen flow battery system includes a stack of flow cells, an electrolyte reservoir and one or more of a concentrated halogen return line fluidly connecting the stack to the reservoir, a venturi, a mixer, a concentrated halogen pump, or a concentrated halogen line heater.
US08945737B2 Application of force in electrochemical cells
The present invention relates to the application of a force to enhance the performance of an electrochemical cell. The force may comprise, in some instances, an anisotropic force with a component normal to an active surface of the anode of the electrochemical cell. In the embodiments described herein, electrochemical cells (e.g., rechargeable batteries) may undergo a charge/discharge cycle involving deposition of metal (e.g., lithium metal) on a surface of the anode upon charging and reaction of the metal on the anode surface, wherein the metal diffuses from the anode surface, upon discharging. The uniformity with which the metal is deposited on the anode may affect cell performance. For example, when lithium metal is redeposited on an anode, it may, in some cases, deposit unevenly forming a rough surface. The roughened surface may increase the amount of lithium metal available for undesired chemical reactions which may result in decreased cycling lifetime and/or poor cell performance. The application of force to the electrochemical cell has been found, in accordance with the invention, to reduce such behavior and to improve the cycling lifetime and/or performance of the cell.
US08945736B2 Method for conditioning membrane-electrode-units for fuel cells
The present invention relates to a method for the conditioning of membrane electrode assemblies for fuel cells in which the output of the membrane electrode assemblies used can be increased and therefore the efficiency of the resulting polymer electrolyte membrane fuel cells can be improved.
US08945735B2 Built-in charge circuit for secondary battery and secondary battery with the built-in charge circuit
A secondary battery which includes a built-in charge circuit. The secondary battery includes a bare cell having a positive electrode and a negative electrode; a protection circuit section electrically connected to the bare cell; a positive electrode charge/discharge terminal and a negative electrode charge/discharge terminal electrically connected to the protection circuit section; a charge circuit section for supplying a charging current to the protection circuit section; and a positive electrode charge terminal and a negative electrode charge terminal electrically connected to the charge circuit section, wherein the charge circuit section includes a first reverse-current prevention part, and a second reverse-current prevention part for preventing damage of the first reverse-current prevention part due to the reversed charge.
US08945729B1 Thermal barrier coating material with RF absorption capabilities at elevated temperatures
Embodiments disclosed herein include compositions that serve, among other things, the dual function of a thermal barrier and an RF absorber. The compositions can be applied as a single layer to an aircraft engine component, thus reducing the weight of the aircraft and eliminating an extra coating step in the manufacturing process. The coating materials are designed to protect the metal underneath from the high temperatures generated during engine operation, and also to absorb or scatter radiation which may incumbent on the metal during operation. In some implementations, the compositions comprise a two phase mixture of perovskite and magnetoplumbite.
US08945725B2 Organic electroluminescence device
The present invention relates to an organic electroluminescence device having high luminous efficiency (for example, external quantum efficiency) and high durability and causing little chromaticity shift after device deterioration. The present invention also relates to an organic electroluminescence device material comprising a substrate having thereon a pair of electrodes and at least one organic layer between the electrodes, the organic layer containing a light emitting layer, wherein the light emitting layer contains a metal complex having a group represented by formula (I).
US08945724B2 Nitrogen-containing heterocyclic derivative and organic electroluminescent device using the same
A novel nitrogen-containing heterocyclic derivative having a specific structure. An organic electroluminescence device comprises an organic thin-film layer which is disposed between a cathode and an anode and comprises one or more layers having a light emitting layer. At least one layer of the organic thin-film layer comprises the nitrogen-containing heterocyclic derivative. The organic electroluminescence device exhibits a high luminance and a high luminous efficiency even at a low driving voltage.
US08945723B2 Organometallic complexes and organic electroluminescence device using the same
An organometallic complex that increases an energy band gap between HOMO and triplet MLCT states, and enables highly efficient phospholuminescence and can be used for an organic electroluminescent device. The organometallic complex, which is suitably used for forming an organic layer of the organic electroluminescent device, provides a luminescence maximum emission in the wavelength range of 400-650 nm, and induces white electroluminescence when combined with green or red luminescent materials.
US08945721B2 Aluminum alloy heat exchanger
An aluminum alloy heat exchanger with aluminum alloy tubes is provided by assembling and brazing. A coating which includes from 1 to 5 g/m2 of Si powder, from 3 to 20 g/m2 of Zn containing flux, and from 0.2 to 8.3 g/m2 of binder is formed on the aluminum alloy tubes. The fins contain Zn and 0.8 to 2.0% by mass of Mn, Si in a ratio of 1/2.5 to 1/3.5 relative to the Mn, and less than 0.30% by mass of Fe. A fillet is formed between the tube and the aluminum alloy fin after brazing, and a primary crystal portion is formed in the fillet. A eutectic crystal portion is formed in a portion other than the primary crystal portion, and the electric potential of the primary crystal portion is equal to or higher than the electric potential of the aluminum alloy fin.
US08945720B2 Hard composite with deformable constituent and method of applying to earth-engaging tool
A hardmetal composite used as wear-resistant surfaces and inlays in earth-engaging equipment includes more than one hardphase. At least one hardphase has a high average particle size, for example, from 100 μm to 2000 μm. The hardphases vary in terms of particle size, hardness, and binder content, and at least one hardphase includes a particulate constituent capable of plastic deformation that comprises at least 1% residual porosity.
US08945712B2 Fluorinated compositions and surface treatments made therefrom
A polymeric or oligomeric composition comprising at least one first divalent unit represented by formula: and at least one of a second divalent unit comprising a pendant phosphonate group —P(O)(OY)2 or a monovalent unit comprising a thioether linkage and a terminal Z group, wherein each Z group is independently —P(O)(OY)2 or —O—P(O)(OY)2. Rf is a perfluoropolyether group. Q is a bond, —C(O)—N(R1)—, or —C(O)—O—. R″, R′″, R and R1 are each independently hydrogen and alkyl having from 1 to 4 carbon atoms. X is alkylene, arylalkylene, and alkylarylene, wherein alkylene, arylalkylene, and alkylarylene are each optionally interrupted by at least one ether linkage. Y is hydrogen, alkyl, trialkylsilyl, and a counter cation. Methods of treating a surface using these compositions and articles with a surface in contact with these compositions are provided. Methods of making these compositions are also provided.
US08945706B2 Polymeric composition for cellulosic material binding and modifications
A polymer composition suitable for wood treatment or binding comprises a reaction product of at least a polyol and at least a crosslinking agent. The crosslinking agent has at least 2 carboxylic acid groups per molecule. A wood product comprising a wood substrate and a polymer composition as well as a wood treatment process are also disclosed.
US08945703B2 Single- or multilayer, stabilized polyester film
The invention relates to a polyester film incorporating at least one UV stabilizer of the formula I, in which R1 is hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, aryl, or heteroaryl, and R2 is a moiety which contains at least one π-electron system, which contains a carbon atom and at least one further atom selected from carbon, oxygen, and nitrogen, where the moiety R2 contains at least one atom different from carbon, where the film includes at least one further UV absorber which does not correspond to the formula I. The invention further relates to a process for producing the film, and also to articles formed from the film.
US08945702B2 Barrier packaging webs having metallized non-oriented film
The present invention provides flexible packaging webs comprising a non-oriented metallized sealant film characterized by a secant modulus of less than 120,000 psi and an elongation at break of greater than 150%, wherein the non-oriented metallized sealant film comprises (1) a thermoplastic base layer of a material selected from the group consisting of ethylene/vinyl alcohol copolymer, ethylene/acrylic acid copolymer, ethylene/norbornene copolymer, polyamide and blends thereof; (2) a metal coating deposited on the base layer and having an optical density of 1.0 to 3.0; and (3) a heat sealing layer. The packaging webs of the present invention each exhibit an oxygen gas transmission rate of between 0 to 10.0 cm3/100 in2/24 hours at 73° F. (0 to 155 cm3/m2/24 hours at 23° C.) and 0% relative humidity and a water vapor transmission rate of between 0 to 0.1 g/100 in2/24 hours at 100° F. (0 to 1.55 g/m2/24 hours at 38° C.) and 90% relative humidity. The sealant films are formed by a blown coextrusion method.
US08945701B2 Ethylene resin composition, sealing material for solar cell, and solar cell module utilizing the sealing material
An ethylene resin composition is provided which has excellent properties including adhesion properties, electrically insulating properties, transparency, moldability and process stability and can be produced without requiring any cross-linking procedure if necessary to improve productivity; and others. The ethylene resin composition contains a modified product produced by modifying an ethylene polymer (A) that meets all of the requirements a) to e) mentioned below with an ethylenically unsaturated silane compound (B). a) The density is 900 to 940 kg/m3. b) The melting peak temperature is 90 to 125 ° C. as determined by DSC. c) The melt flow rate (MFR2) is 0.1 to 100 g/10 minutes as measured at 190 ° C. and a load of 2.16 kg in accordance with JIS K-6721. d) The Mw/Mn ratio is 1.2 to 3.5. e) The content of metal residues is 0.1 to 50 ppm.
US08945698B2 Honeycomb structure and method for manufacturing the same
A honeycomb structure includes porous partition walls via which a plurality of cells constituting through channels for a fluid are partitioned; and an outer peripheral wall positioned in the outermost periphery of the structure. Open frontal areas of predetermined cells in an end face of the structure on a fluid inlet side thereof and open frontal areas of remaining cells an end face of the structure on a fluid outlet side thereof are provided with plugged portions. Bubbles are formed in the plurality of plugged portions, and the center of each of the bubbles is positioned in a predetermined region of each of the plugged portions along the central axis direction thereof.
US08945696B2 Round paper towel and napkin product
An apparatus for Round Paper Product and Napkin product is to provide to provide a more practical, attractive, and environmentally sound alternative to standard, square shaped paper towels and napkins featuring a distinct circular shape for easy placement in microwaves. ea
US08945693B2 Printable articles including coating/ink-receiving layers and methods of preparation thereof
Printable articles having a single coating/ink receiving layer are disclosed. In addition, printable articles having a single coating/ink receiving layer disposed on the printable article and a second coating layer disposed on the coating/ink receiving layer are disclosed.
US08945683B2 Prepreg for fiber reinforced plastic and production process thereof
A prepreg of FRP (fiber reinforced plastic) having with (i) a matrix resin composition containing a bifunctional isocyanate and/or a trifunctional isocyanate, a polyol and a bifunctional chain extender having two active hydrogen groups at a molar ratio, as a functional group, of isocyanate:polyol:chain extender=5.0 to 1.0:1.0:4.0 to 0, or containing a bifunctional isocyanate and/or a trifunctional isocyanate and a polyol at a molar ratio, as a functional group, of liquid isocyanate:polyol=0.9 to 1.1:1.0; and (ii) a fibrous material. A production process of the prepreg. According to the present invention, the prepreg has a sufficient pot life and permits convenient production of an FRP molding.
US08945680B2 Method for the establishment of a crack resistant epoxy paint coat and paint compositions suitable for said method
The present invention relates to a method for the establishment of a crack resistant epoxy paint coat and paint compositions suitable for said method. The method is developed for use in ballast tanks e.g. a ballast tank of a vessel. The method involves the steps: (i) applying a paint composition comprising an epoxy-based binder system onto the surface thereby forming a curable paint film on the surface, and (ii) allowing the curable paint film to cure thereby forming the epoxy paint coat. The paint composition has a viscosity of at the most 140 KU, when ready to be applied. The paint composition comprises 35-80% by solids volume of the paint of an epoxy-based binder system having a ratio between the hydrogen equivalents and the epoxy equivalents in the range of 20:100 to 120:100. The paint composition furthermore comprises 0.5-30% by solids volume of the paint of one or more fibers. The fibers have an average length, of at the most 250 μm.
US08945679B2 Apparatus for impregnating web-like materials with thermally curable impregnating resin
An apparatus for impregnating web material with thermally curable impregnating resin, The apparatus includes an impregnating trough in which the web material is brought into contact with the impregnating resin and an inlet line which leads to the impregnating trough and through which the impregnating resin is introduced into the impregnating trough. The apparatus also includes a heating device structured and arranged for heating the impregnating resin, wherein the heating device is associated with the inlet line and heats the impregnating resin in the inlet line.
US08945676B2 Method and apparatus for coating
The invention relates to a method and an apparatus for coating one or more objects (1) by exposing an object (1) to alternately repeating surface reactions of two or more gaseous precursors. The apparatus comprises a reaction chamber (2, 40), means for forming at least one distinct precursor region inside the reaction chamber, and means for causing translational, essentially mechanically unsupported and unsuspended, motion of an object (1) inside the reaction chamber, relative to the reaction chamber, for bringing the surface of the object (1) into contact with a gaseous precursor, the means for causing the translational motion comprising means for moving the object (1) essentially through the at least one distinct precursor region inside the reaction chamber.
US08945672B2 Process for preparing compacted pigment granules, process for preparing encapsulated pigment granules, and process for dyeing landscaping and/or construction materials
A process for preparing encapsulated pigment granules, including the steps of (1) loading iron oxide powder into a mixer; (2) rotating the mixer to cause the iron oxide powder to continuously cascade within the mixer, so as to form compacted pigment granules; and (3) spraying liquid encapsulation solution onto the cascading compacted pigment granules to cause the cascading compacted pigment granules to be encapsulated.
US08945670B2 Process for the production of a deposit of inorganic nanoparticles having micro gaps onto a light-transparent support
The invention relates to a process for the production of a transparent support covered with a deposit of inorganic nanoparticles, said deposit having micro gaps, comprising the following steps: application of a solution of polyelectrolyte having ionized functional groups to a transparent support, followed by at least one washing and drying step to form a charged polyelectrolyte deposit on said support; application of a solution of polymer microparticles having ionized groups with charges opposed to those of the polyelectrolyte deposit to said polyelectrolyte deposit, followed by at least one washing step for the formation of a deposit of charged polymer microparticles on the polyelectrolyte deposit; covering the deposit of charged polymer microparticles with a solution of polyelectrolyte having ionized functional groups with charges opposed to those of the charged polymer microparticles of step (b), followed by at least one washing and drying step to form a charged polyelectrolyte deposit; application of a solution of ionized inorganic nanoparticles having surface charges opposed to those of the charges of the polyelectrolyte of step (c) to the charged polyelectrolyte deposit, followed by at least one washing step to form at least one layer of ionized inorganic nanoparticles; removal of the deposit of polymer microparticles of step (b) and the deposits of polyelectrolyte of steps (a) and (c) to obtain the deposit of inorganic nanoparticles having micro gaps.
US08945667B2 Alkylcellulose and salt compositions for dust control applications
A method of reducing dust generation from an aggregate surface is described. The method includes applying a dust suppression compound to the aggregate surface. The dust suppression compound may be made from an aqueous mixture of an alkylcellulose compound and a halogen containing salt.
US08945662B2 Rotary slide stainer
A slide stainer and a method for operating the slide carrier is disclosed. The slide stainer includes a slide carrier that carries one or more laboratory slides; a vessel that is capable of carrying fluid for staining the laboratory slides and that is sized to accommodate the laboratory slides; a slide transporter that moves the slide carrier into and out of the vessel; and a spring loaded pin that engages with a surface of the slide stainer to limit free-fall translation of the slide carrier in an event of a power loss. Additionally, during an agitation phase of a slide staining process, the slide transporter is configured to translate the slide carrier in an upward direction to a pre-determined height that is set by a user of the slide stainer, and the slide transporter translates the slide carrier in a downward direction back into the vessel.
US08945661B1 Snack manufacturing process
A snack-making process for manufacturing jujube snacks includes the following steps. Jujube fruit is harvested from a certain elevation above sea level. The fruit is air dried for between 30 and 120 days with substantially daily exposure to sunlight. The fruit is rinsed with water and air dried naturally between 30 and 60 minutes. The seeds are removed from the fruit and sliced into annular slices. The slices are baked for between 240 minutes to 360 minutes at a temperature of between 142 and 194 degrees F. The slices are cooled for between 30 minutes to 60 minutes at a temperature of between 50 and 60 degrees F. The slices are then cooled to below 15 degrees F. while maintaining the water content of the slices to less than 5%. The snack-making process may include the step of introducing a flavoring substance to the slices.
US08945656B2 Jamun juice composition and a process thereof
This invention is related to a shelf stable jamun juice composition comprising of jamun pulp, water and juice concentrate, wherein the juice concentrate is deionized fruit juice concentrate. This invention is also related to a process of preparation of the said composition. This invention also relates to a process of preparation of jamun pulp. The composition wherein, it is without added sugar and preservative is more delectable.
US08945652B2 High-potency sweetener for weight management and compositions sweetened therewith
The present invention relates generally to functional sweetener compositions comprising non-caloric or low-caloric natural and/or synthetic high-potency sweeteners and methods for making and using them. In particular, the present invention relates to different functional sweetener compositions comprising at least one non-caloric or low-caloric natural and/or synthetic high potency sweetener, at least one sweet taste improving composition, and at least one functional ingredient, such as a weight management agent. The present invention also relates to functional sweetener compositions and methods that can improve the tastes of non-caloric or low-caloric high-potency sweeteners by imparting a more sugar-like taste or characteristic. In particular, the functional sweetener compositions and methods provide a more sugar-like temporal profile, including sweetness onset and sweetness linger, and/or a more sugar-like flavor profile.
US08945644B2 Process to remove impurities from triacylglycerol oil
The present invention is directed to a process to remove impurities from triacylglycerol oil including mixing the oil and a fluidic agent, pumping the mixture through a flow-through hydrodynamic cavitation apparatus at a pre-determined inlet pump pressure, creating hydrodynamic cavitation in the mixture, maintaining the hydrodynamic cavitation for a pre-determined period of time, moving the impurities from the oil to the fluidic agent, and then separating the fluidic agent from the oil. The impurities can include phytosterols, sterol glucosides, acylated sterol glucosides, in which case the fluidic agent is water, an alkali hydroxide, an inorganic base, an organic base, phosphoric acid, citric acid, acetic acid or a mixture thereof. The impurities may also include phosphatides, in which case and the fluidic agent comprises water and an enzyme such as phospholipase, a lipid acyltransferase or a mixture thereof.
US08945642B2 Nutritionally enhanced isolate from stabilized rice bran and method of production
Provided is a nutritionally enhanced derivative (isolate) from Stabilized Rice Bran (SRB) with improved antioxidant, fat and protein levels enhancing both the nutritional and yield values over existing techniques. Also provided is an improved method that utilizes certain enzyme combinations under various time and temperature conditions for extracting these nutritionally enhanced isolates from SRB.
US08945638B2 Alcohol extract of dehulled adlay seeds for treating gastric ulcer and/or stomach cancer
The present invention provides a method for treating gastric ulcer and/or stomach cancer in a subject, which comprises administering to said subject an effective amount of an alcohol extract of dehulled adlay seeds. Preferably, an ethyl acetate sub-fraction of the alcohol extract of dehulled adlay seeds has a better effect in treating gastric ulcer and/or stomach cancer.
US08945637B2 Decubitus treatment system
The present invention includes compositions and methods for cleaning, treating, protection and resolution of decubitus ulcers comprising: a first composition comprising a wound cleaning solution comprising aloe vera gel comprising at least 5,000 MPS, a balanced salt solution; and a second composition comprising a wound healing gel comprising aloe vera gel comprising at least 10,000 MPS, a thickening agent, and one or more preservatives and, optionally, a third composition comprising a moisture barrier cream comprising a vegetable-based emulsifier, a cosmetic ester for dry skin that has low occlusivity, an ester-based emollient that is oxidation stable and has low occlusivity; a beeswax; a hydrogenated oil, glycerin, a buffering agent, aloe vera gel comprising at least 2,000 MPS and water.
US08945636B2 Stabilized formulation comprising omega-3 fatty acids and use of the fatty acids for skin care and/or wound care
A stabilized formulation for skin care, wound care and/or other tissue healing applications and methods for making the same is described. The stabilized formulation stabilizes omega-3 polyunsaturated fatty acids and is constituted of the omega-3 polyunsaturated fatty acids in combination with tocopherol (Vitamin E), ascorbic acid (Vitamin C), herb extract, and a fat-soluble antioxidant. Methods for making and using the stabilized formulation are also described.
US08945635B2 Formulations comprising extracts from primitive plant species (mosses, ferns and lichens) to treat and prevent cancers
Disclosed are extracts prepared from primitive plants and fungi that have anti-cancer properties. The extracts are prepared by pulverizing the biological matter in a diluent. The extract can be administered to an individual or animal to kill cancer cells, prevent growth of cancer cells and teat cancer. The extracts may be used in combination with other therapeutic protocols.
US08945631B2 Liquid for treatment of citrus greening disease and treatment method using same
Provided are: a liquid for treatment of Citrus greening disease, which is capable of curing citrus trees with Citrus greening disease; and a treatment method using the liquid. The liquid for treatment of Citrus greening disease contains Fe ions and at least some of the Fe ions are present in the form of Fe2+ ions. This treatment liquid contains a predetermined amount of Fe ions and an acid. Citrus greening disease is able to be cured by spraying the treatment liquid onto leaves of citrus trees infected with Citrus greening disease or by pouring the treatment liquid on the roots of citrus trees infected with Citrus greening disease.
US08945630B2 Method of producing and applications of composition of hypochlorous acid
A method for preparing a stabilized antimicrobial hypochlorous acid solution by diluting an aged stock solution to provide a hypochlorous acid solution at a concentration of about 50 to about 7000 ppm at a pH range of about 2.8 to about 4.0. The antimicrobial hypochlorous acid solution maintains at least 75 percent of the available chlorine present over a period of about 6 months to about 12 months. The antimicrobial hypochlorous acid solution has medical applications in humans and veterinary practice, both prophylactic and therapeutic. The solution can also be used for non-medical applications in antisepsis and sterilization of surfaces.
US08945628B2 Magnetic nanoparticles
A magnetic nanoparticle includes a magnetic core and a superparamagnetic outer shell, in which the outer shell enhances magnetic properties of the nanoparticle. The enhanced magnetic properties of the magnetic nanoparticle allow for highly sensitive detection as well as diminished non-specific aggregation of nanoparticles.
US08945627B2 Micelles for the solubilization of gossypol
The invention provides biocompatible micelles loaded with one or more active agents. The micelles can encapsulate anticancer drugs such as gossypol, and combinations of drugs, such as gossypol and paclitaxel, gossypol and 17-AAG, gossypol and cyclopamine, gossypol, paclitaxel, and 17-AAG, and gossypol, paclitaxel, and cyclopamine. The micelle compositions provide effective solubilization of difficult to solubilize drug combinations without the need for additional surfactants that can be toxic to patients. Thus, the invention provides stable and biocompatible drug formulations that improve bioavailability without causing toxicity.
US08945625B2 Regulated delivery systems for inner ear drug application and uses thereof
The invention relates to a controlled release delivery compositions and methods of using them for pathologies associated with Otorhinolaryngology and Head and Neck. Specifically, the invention relates to regulating drug delivery by the use of chitosan based matrices together with chitosanases.
US08945622B2 Sustained release composition of therapeutic agent
A pH dependent drug delivery system comprising a pH sensitive graft copolymer, a therapeutically active agent and other pharmaceutically acceptable ingredients. More specifically, a composition which is capable of suppressing the drug release in the acidic pH prevalent in the stomach and releasing the drug over an extended period of time at pH prevalent in the intestinal region.
US08945618B2 Intrabuccally rapidly disintegrating tablet and a production method of the tablets
An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.
US08945617B2 Extrudate and methods of using said extrudate
The invention relates to a method for the preparation of a silicic acid comprising extrudate, comprising the steps of: i) forming of stabilized silicic acid, by hydrolyzing a silicon compound into orthosilicic acid and/or oligomers thereof in the presence of a stabilizing agent, which is a quaternary ammonium compound, or an amino-acid, or an amino acid source or combinations thereof; ii) mixing of the stabilized silicic acid with a carrier in an amount up to the loading capacity of the carrier for silicic acid; and iii) extruding the resulting mixture thereby forming the extrudate, to extrudates obtainable with the method, to an extrudate for use in the production of animal feed, feed supplement, human food and/or food supplement and of a pharmaceutical or cosmetic preparation, and for the treatment of infections, nails, hair, skin, teeth, collagen, connective tissue, bones, osteopenia, cell generation and degenerative (ageing) processes, and to a pharmaceutical composition comprising an extrudate.
US08945602B2 Porous photonic crystals for drug delivery to the eye
A minimally invasive controlled drug delivery system for delivering a particular drug or drugs to a particular location of the eye, the system including a porous film template having pores configured and dimensioned to at least partially receive at least one drug therein, and wherein the template is dimensioned to be delivered into or onto the eye.
US08945600B2 Methods of delivering pharmaceutical agents
Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological disorder or pain in a subject that include administering at least one pharmaceutical agent onto a SEM graft in the skull base of the subject. Also provided are methods of treating a neurological disorder or pain in a subject that include forming a SEM graft in the skull base of the subject and administering at least one pharmaceutical agent onto the SEM graft in the skull base of the subject. Also provided are methods of forming a SEM graft in the skull base of a subject, compositions for administration onto a SEM graft in the skull base or into an endonasal reservoir or endonasal reservoir device in a subject, and devices for administering such compositions onto a SEM graft in the skull base of a subject.
US08945593B2 Orally ingested metabolic enhancer in oral thin film container
An orally ingestible energy-boosting device is provided for facilitating a temporary metabolic increase in a user. The device comprises a small container filled with an energy-enhancing substance. All or a portion of the small container is constructed of a water or saliva-soluble film that dissolves when placed in the mouth of a user. When the film dissolves, energy-enhancing substance is released into the mouth where it is absorbed. The small container may come in a variety of shapes and configurations to meet the varied energy boost needs of users.
US08945592B2 Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
Compositions and methods effective to minimize or eliminate the presence of oxidative degradation products in solid dosage forms comprising sufentanil are provided.
US08945588B2 Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve an Ebh antigen.
US08945581B2 Process for producing poxviruses and poxvirus compositions
The present invention relates to compositions and pharmaceutical compositions comprising poxviruses and more particularly extracellular enveloped viruses. The present invention also relates to a process for producing poxviruses and poxviruses obtained thereof. Moreover, the present invention also relates to the use of said poxvirus and said composition for the preparation of a medicament.
US08945579B2 Methods of treatment with compositions that include hemagglutinin
Methods that stimulate a protective immune response in a subject include a portion of a protein from a naturally occurring viral hemagglutinin, wherein the protein portion includes at least a portion of a globular head and at least a portion of at least one secondary structure that causes the globular head to essentially retain its tertiary structure, and wherein the protein portion lacks a transmembrane domain, a cytoplasmic domain and an HA2 subunit. Compositions administered to the subject can further include a carrier and can be administered in single or multiple doses.
US08945576B2 Vaccine for treatment of tautopathy
This invention relates to a vaccine for preventing or treating tautopathy, comprising a vector, as an active ingredient, comprising a nucleic acid encoding a mutant tau protein linked to a secretion signal sequence, wherein the vaccine is capable of inducing an antibody against an (optionally phosphorylated) tau protein in a subject in a more sustained manner compared with a case where the mutant tau protein is administered directly.
US08945575B2 Treatment of IgE-mediated disease
The methods and compositions described herein are based, in part, on the discovery of a polypeptide of soluble CD23 (sCD23) that binds and sequesters IgE. Thus, the sCD23 peptides, polypeptides and derivatives described herein are useful for treating conditions or disorders involving increased IgE levels such as e.g., allergy, anaphylaxis, inflammation, lymphoma, and certain cancers.
US08945565B2 Methods of treating inflammatory or thrombotic conditions with anti-P-selectin antibodies
Antibodies are disclosed which bind specifically to P-selectin and which block the binding of PSGL-1 to P-selectin. These anti-P-selectin antibodies may also cause dissociation of preformed P-selectin/PSGL-1 complexes. The disclosure identifies a heretofore unrecognized, near N-terminal, antibody binding domain (a conformational epitope) of P-selectin to which the function-blocking antibodies (which may be chimeric, human or humanized antibodies for example) bind. Antibodies are disclosed which bind to the conformational epitope of P-selectin and which have a dual function in blocking binding of PSGL-1 to P-selectin, and in causing dissociation of preformed P-selectin/PSGL-1 complexes. Such single and dual function anti-P-selectin antibodies and binding fragments thereof may be used in the treatment of a variety of inflammatory and thrombotic disorders and conditions. Screening methods for identifying such antibodies are also disclosed.
US08945564B2 Antagonist anti-CD40 antibody pharmaceutical compositions
Stable liquid pharmaceutical compositions comprising an antagonist anti-CD40 antibody as a therapeutically or prophylactically active component and methods useful in their preparation are provided. These compositions comprise the antagonist anti-CD40 antibody, a buffering agent to maintain the pH of the composition between about pH 5.0 and about pH 7.0, and an amount of arginine-HCl sufficient to render the liquid composition near isotonic. The stable liquid antagonist anti-CD40 antibody-containing pharmaceutical compositions of the invention find use in methods for treating proliferative diseases and diseases having an autoimmune and/or inflammatory component.
US08945563B2 Method for treating glioblastoma using antibodies binding to the extracellular domain of the receptor tyrosine kinase ALK
The present invention concerns an antibody specific for human ALK (Anaplastic Lymphoma Kinase), in particular a scFv, a nucleic acid sequence encoding it, its production and its use as a pharmaceutical or for diagnostic purposes. Said antibody is suitable for the local treatment of tumors, in particular glioblastoma.
US08945560B1 Method of treating rheumatoid arthritis using antibody to IL6R
The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.
US08945559B2 Stabilized formulations containing anti-interleukin-4 receptor (IL-4R) antibodies
The present invention provides pharmaceutical formulations comprising a human antibody that specifically binds to human interleukin-4 receptor (hIL-4R). The formulations may contain, in addition to an anti-hIL-4R antibody, at least one amino acid, at least one sugar, or at least one non-ionic surfactant. The pharmaceutical formulations of the present invention exhibit a substantial degree of antibody stability after storage for several months.
US08945556B2 RAF gene fusions
The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to RAF gene fusions as diagnostic markers and clinical targets for cancer.
US08945555B2 Inotropic antibodies and therapeutic uses thereof
Antibodies binding to sites on the alpha-subunit of the (Na++K+)-ATPase increase cardiac contraction of both ventricular myocytes and mouse heart. In particular, antibodies binding to the RSATEEEPPNDD (SEQ ID NO: 1) or DVEDSYGQQWTYEQR (SEQ ID NO: 2) peptides (or isoforms/derivatives thereof) of the alpha-subunit of the (Na++K+)-ATPase, have been found to be highly inotropic. Both the antibodies and the peptides are important for the treatment of human heart failure and other contractile disorders.
US08945554B2 Class I anti-CEA antibodies and uses thereof
The present invention provides compositions and methods of use of humanized, chimeric or human Class I anti-CEA antibodies or fragments thereof, preferably comprising the light chain variable region CDR sequences SASSRVSYIH (SEQ ID NO:1); GTSTLAS (SEQ ID NO:2); and QQWSYNPPT (SEQ ID NO:3); and the heavy chain variable region CDR sequences DYYMS (SEQ ID NO:4); FIANKANGHTTDYSPSVKG (SEQ ID NO:5); and DMGIRWNFDV (SEQ ID NO:6). The Class I anti-CEA antibodies or fragments are useful for treating diseases, such as cancer, wherein the diseased cells express CEACAM5 and/or CEACAM6 antigens. The Class I anti-CEA antibodies or fragments are also of use for interfering with specific processes, such as metastasis, invasiveness and/or adhesion of cancer cells, or for enhancing sensitivity of cancer cells to cytotoxic agents and have favorable effects on the survival of subjects with cancer.
US08945552B2 Bispecific, bivalent anti-VEGF/anti-ANG-2 antibodies
The present invention relates to bispecific, bivalent antibodies against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
US08945551B2 Biopolymer hybrid gel-depot delivery system
The invention relates to biopolymer-gel based depot systems for prolonged and/or controlled release delivery of biologically active agents, methods for the manufacture of the biopolymer based gel-depots which include a biologically active agent, and uses of such biopolymer gel-depots in therapy. The biopolymer-gel based depot systems comprise a biocompatible polyaminosaccharide and/or protein; a biocompatible phosphate and/or sulphonamide compound; a biologically active agent; an aqueous insoluble alkaline earth metal phosphate; and a biocompatible glycan and/or proteoglycan.
US08945544B2 Immunogenic compositions comprising progastrin and uses thereof
The present invention is drawn to immunotherapeutic methods to treat tumors/cancers that produce progastrin ectopically or are dependent on progastrin for their growth. Disclosed herein are immunogenic compositions comprising agents that target progastrin, agents that target the progastrin receptor, annexin II, or both. Such a composition may be administered in combination with chemotherapy or to an individual who had been previously subjected to chemotherapy or radiation therapy. The cancers that may be treated using such a composition may include but are not limited to colon cancer, breast cancer, lung cancer or pancreatic cancer.
US08945543B2 Stabilizer for protein preparation comprising meglumine and use thereof
An objective of the present invention is to provide methods for stabilizing proteins and methods for suppressing protein aggregation, which comprise the step of adding meglumine to the proteins. Another objective of the present invention is to provide agents for suppressing protein aggregation, which comprise meglumine. Still another objective of the present invention is to provide pharmaceutical compositions comprising antibody molecules stabilized by meglumine, methods for producing the pharmaceutical compositions, and kits comprising the pharmaceutical compositions.To achieve the objectives described above, the present inventors assessed the antibody-stabilizing effect of meglumine, an amino sugar. As a result, the inventors discovered that meglumine was useful as a stabilizer for antibody molecules and also as an excipient for freeze-dried preparations.
US08945541B2 Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
US08945539B1 Enzyme and prebiotic combinations for enhancing probiotic efficacy
This disclosure relates to enhancing growth and/or activity of lactobacilli using a prebiotic formulation which includes iso-malto oligosaccharides and α-galactosidase; and to enhancing growth and/or activity of bifidobacteria using a prebiotic formulation which includes iso-malto oligosaccharides and β-glucanase. Other combinations of fibers and enzymes are described below which also stimulate growth and activity of lactobacilli or bifidobacteria. These combinations of enzymes and prebiotics can be taken separately or added to foods, including desserts.
US08945538B2 Bone substitute compositions, methods of preparation and clinical applications
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate, acidic calcium salt, basic calcium salt, sodium hydrogen phosphate and porogen. The compositions further include a mixing liquid. The compositions can optionally include biological signaling molecules and/or a growth compound. Further, the compositions can optionally include a plasticizer.
US08945536B2 Stem cell sheet for tissue repair
Disclosed is a cell sheet for tissue repair and bio-artificial tissue engineering. The cell sheet comprises treated stem cell embedded in its self-secreted extracellular matrix (ECM) and formed a cell sheet. The cell sheet is formed by isolating the stem cell, expanding the stem cell and treating the stem cell with biological factors or factors leading to the production of biological factors, to induce its differentiation, production of extracellular matrix and formation of a cell sheet in vitro. The cell sheet is used as a bioactive material or as an acellular material for the promotion of tissue repairs or used to form a bio-artificial organ for tissue replacement. The cell sheet of the present invention eliminates the need to use scaffolds for cell delivery. The cell sheet facilitates in vivo cell transplantation and provides some tensile mechanical strength for bearing early mechanical load during tissue repair.
US08945532B2 Anti-aging formulations
A dietary supplement based on fucoidan, blue-green algae, phycocyanin and phenylethylamine is fortified with one or more of curcumin, silymarin, resveratrol, astragalus root extract, astragoloside IV, vitamin D3, vitamin C, anhydrous trimethylglycine and brewers yeast to stimulate stem cell production and reduce the rate of telomere reduction or shortening. This can result in the repair of existing body cells and enhance longevity by stimulating the production of new stem cells and maintaining the telomeres on new stem cells as well as existing cells. The dietary supplement supports an increased life span by enhancing metabolic function, activating SIRT-1 anti-aging genes, and encouraging the production of new cells with longer telomeres.
US08945531B2 Recombinant herpes virus and pharmaceutical composition containing the same
A recombinant herpes virus showing high antitumor activity is provided. In particular, a recombinant herpes simplex virus that expresses an ICP6 gene under control of a tumor-specific promoter or tissue-specific promoter on the genome of the virus is provided.
US08945530B2 DNA sequence, and recombinant preparation of the grass pollen allergen Lol p4
The present invention relates to the provision of a DNA sequence of the major grass pollen allergen Lol p 4. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for in vitro and in vivo diagnosis of pollen allergies.
US08945529B2 Biphasic lipid-vesicle compositions
A biphasic lipid vesicle composition for treating cervical displasia by intravaginal delivery. The composition includes a suspension of lipid-bilayer vesicles having entrapped therein, an oil-in-water emulsion, human interferon alpha-2b and L-methionine, the composition having an interferon alpha-2b specific activity of between about 1-10 MIU (million international units) per gram composition, and between 0.01 to 0.5 weight percent L-methionine. In the treatment method, the composition is administered at a dose of between about 1-20 MIU interferon alpha-2b, and this dose is administered at least 3 days/week, for a period of at least 4 weeks.
US08945528B2 Use of interleukin-22 in treating viral hepatitis
This invention relates to a use of IL-22 in the treatment of viral hepatitis. As illustrated in the examples of this invention, IL-22 can significantly reduce liver damage caused by hepatitis virus, and can significantly reduce the increase of transaminase ALT/AST induced by hepatitis virus. In addition, the IL-22 dimer of this invention can effectively treat viral hepatitis.
US08945525B2 Comfortable, long-wearing, transfer-resistant colored cosmetic compositions having high gloss and a non-tacky feel
The present invention is directed to an anhydrous glossy composition which is long wearing and transfer resistant, while at the same time providing superior comfort, non-tacky feel and cushioning, the composition containing (a) at least one siloxysilicate resin; (b) at least one polyorganosiloxane-containing polymer; (c) at least one volatile solvent; (d) at least one non-volatile solvent having more than one phenyl group; and (e) optionally, at least one colorant; and wherein the ratio by weight of (b) to (a) is greater than or equal to 1.
US08945524B2 Cosmetic heat treatment method
A method of makeup and/or non-therapeutic care for non-fibrous human keratin material, particularly the skin, the mucus membranes thereof, or the nails, including: bringing an outer surface of a piece of solid cosmetic composition, having a temperature-sensitive dynamic rub coefficient, into contact with, or near, a heating device, said dynamic rub coefficient, at 25° C., being greater than or equal to 0.5, preferably 0.6, so as to heat said piece in a localized manner with a view to essentially softening only said outer surface and lowering the dynamic rub coefficient thereof; and applying the outer surface of the thus-heated composition onto the area to be treated.
US08945523B2 Skin lightening composition for hyperpigmented skin
An improved skin composition intended for topical application to skin for lightening hyperpigmented skin is provided. The subject composition is characterized by incorporation of at least one carbohydrate-based melanin inhibiting agent selected from bearberry extract, ascorbyl glucoside, rutin and arbutin into an ultra low molecular weight aminoglycan polymer gel. It has been found that the skin composition of the present invention possesses improved skin penetration and significantly enhances the depigmenting effect of the active agents.
US08945522B2 Silyl polymeric benzoic acid ester compounds, uses, and compositions thereof
The present invention relates to organosilicon polymers containing benzoic acid esters in form of particles, process for their preparation, cosmetic or dermatological composition comprising them, as well as their use for protecting a human or animal living body from UV radiation.
US08945517B2 Continuous silica production process and silica product prepared from same
Disclosed herein is a continuous process for preparing a silica product, comprising: (a) continuously feeding an acidulating agent and an alkali metal silicate into a loop reaction zone comprising a stream of liquid medium; wherein at least a portion of the acidulating agent and the alkali metal silicate react to form a silica product in the liquid medium of the loop reaction zone; (b) continuously recirculating the liquid medium through the loop reaction zone; and (c) continuously discharging from the loop reaction zone a portion of the liquid medium comprising the silica product. Silica products and dentifrice compositions comprising the silica products are also disclosed. A continuous loop reactor is also disclosed.
US08945515B2 Methods and compositions for altering photophysical properties of fluorophores via proximal quenching
The invention is directed to fluorophore-containing compositions and configurations wherein proximity between the fluorophore and one or more protective agents (PAs) modifies the lifetime of fluorescent and/or dark states, their frequency of occurrence, and the total lifetime of fluorescence in order to appropriately modify the photophysical characteristics of the fluorophore. The invention is also directed to methods that utilize these compositions and configurations.
US08945512B2 Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for “cest” applications
Disclosed are CEST paramagnetic agents comprising a substrate (SH) containing mobile protons bonded to a paramagnetic chelate (SR) containing a metal selected from iron (11) (high-spin configuration), iron (111), cobalt (11), rhodium (11), copper (11), nickel (11), cerium (111), praseodymium (111), neodymium (111), dysprosium (111), erbium (111), terbium (111), holmium (111), thulium (III), ytterbium (III) and europium (111).
US08945511B2 Sensitive methods for detecting the presence of cancer associated with the over-expression of galectin-3 using biomarkers derived from galectin-3
Described herein are sensitive methods for determining if a subject has cancer. The methods generally involve quantifying the amount of one or more biomarkers derived from Galectin-3 in a biological sample from the subject by mass spectrometry, wherein an increase in the amount of one or more biomarkers in the biological sample as compared to a control is an indication of the presence of cancer in the subject.
US08945509B2 Magnetic beads having surface glycoconjugates and use thereof
Magnetic beads that include polyvalent ligands comprising various carbohydrates are described. Methods for fabricating such magnetic beads are also provided as well as methods of their use to capture and enrich pathogen cell population for subsequent culture, lysis and identification.
US08945507B2 Systems and methods for operating a gasifier
Systems and methods for operating a gasifier are provided. The method can include combusting a first start-up fuel to produce a first combustion gas. A temperature within the gasifier can be increased from a starting temperature to at least an auto-ignition temperature of a second start-up fuel by introducing the first combustion gas to the gasifier. A second start-up fuel can be introduced directly to the gasifier after the temperature within the gasifier is at least the auto-ignition temperature of the second start-up fuel. At least a portion of the second start-up fuel can be combusted within the gasifier to produce a second combustion gas. The second combustion gas can produce sufficient heat to increase the temperature within the gasifier to a hydrocarbon feedstock gasification temperature. A hydrocarbon feedstock can be introduced to the gasifier. At least a portion of the hydrocarbon feedstock can be gasified within the gasifier to produce a syngas.
US08945504B2 Nanostructured metal oxides comprising internal voids and methods of use thereof
The present invention relates to nano structures of metal oxides having a nanostructured shell (or wall), and an internal space or void. Nanostructures may be nanoparticles, nanorod/belts/arrays, nanotubes, nanodisks, nanoboxes, hollow nanospheres, and mesoporous structures, among other nanostructures. The nanostructures are composed of polycrystalline metal, oxides such as SnO2. The nanostructures may have concentric walls which surround the internal space of cavity. There may be two or more concentric shells or walls. The internal space may contain a core such ferric oxides or other materials which have functional properties. The invention also provides for a novel, inexpensive, high-yield method for mass production of hollow metal oxide nanostructures. The method may be template free or contain a template such as silica. The nanostructures prepared by the methods of the invention provide for improved cycling performance when tested using rechargeable lithium-ion batteries.
US08945499B2 Process for producing ammonium nitrate
A process for producing ammonium nitrate is disclosed, which process comprises exposing a gaseous oxidiser feed composed at least substantially of ammonia, steam and an oxidising gas to conditions whereby the ammonia is oxidised to produce a reaction mixture including nitrogen monoxide and water vapour. The reaction mixture is cooled in a heat exchanger whereby the nitrogen monoxide is oxidised, the water vapour is condensed and the products of the nitrogen monoxide oxidation react with and are absorbed by the condensed water to form a nitric acid stream, with substantially all of the nitrogen monoxide in the reaction mixture being converted to nitric acid. The nitric acid stream is reacted with a stream of ammonia to form the ammonium nitrate.
US08945497B2 Catalyst and process
The invention concerns a process for the oxidation of organic compounds contained in a gas stream and comprises the step of introducing the gas stream containing the organic compounds together with sufficient oxygen to effect the desired amount of oxidation into an oxidation reactor containing an oxidation catalyst and maintaining the temperature of said gas stream at a temperature sufficient to effect oxidation, characterised in that the oxidation catalyst contains at least 0.01% by weight of ruthenium, cobalt or manganese.
US08945490B2 Methods of metal extraction using oximes
Provided are methods method of recovering metal from an aqueous solution, the method comprising contacting an aqueous solution containing at least two metals selected from molybdenum, cobalt, nickel, zinc and iron with an organic solvent and an oxime-containing reagent composition at a predetermined pH, the predetermined pH selected to provide a high first metal extraction and a low second metal extraction; and separating the first metal from the solution.
US08945489B2 Metal recovery process
A process for recovering a metal chloride or mixed metal chloride from a solid waste material comprising recoverable metal containing constituents produced by lead, copper or zinc smelting and refining processes, said process comprising the steps of: (i) heating the solid waste material; (ii) treating the heated material of step (i) with a gaseous chloride to form a gaseous metal chloride containing product; and (iii) treating the gaseous metal chloride containing product of step (ii) to recover the metal chloride or mixed metal chloride. The metal chloride may be further treated to extract the metal itself.
US08945485B2 Systems and methods for providing microfluidic devices
A microfluidic valve system is disclosed that includes a matrix, a hydrophilic acceptor region a hydrophilic transfer region, and a hydrophobic gap between the acceptor region and the transfer region.
US08945484B2 Microfluidic device including microvalve
A microfluidic device including at least one microvalve which controls a flow of a fluid, where the at least one microvalve includes: a pneumatic layer, a fluidic layer disposed opposite to the pneumatic layer; an elastomer membrane disposed between the pneumatic layer and the fluidic layer; and an asymmetric valve seat protruding from a surface of the fluidic layer toward a surface of the elastomer membrane and asymmetrically dividing a space between the fluidic layer and the elastomer membrane.
US08945483B2 Method for attaching RFID tag of memory cassette for tissue specimen and memory cassette for tissue specimen having RFID tag
Disclosed are a method for attaching an RFID tag to a memory cassette for tissue specimens and a memory cassette for tissue specimens having the RFID tag attached thereto, in which the RFID tag is attached to the memory cassette for tissue specimens and the RFID tag operates stably even when the memory cassette having the RFID tag attached thereto comes in contact with chemicals or is submerged in various chemical solutions. The method includes forming the memory cassette for tissue specimens provided on an inclined plane of a front surface of a body with an RFID tag insertion groove, inserting the RFID tag into the RFID tag insertion groove provided on the inclined plane of the body, and attaching a protective cap onto the top of the inclined plane of the body in which the RFID tag is inserted into the RFID tag insertion groove, and coupling the protective cap to the inclined plane of the body by ultrasonic welding to adhere the RFID tag to the body of the memory cassette for tissue specimens. Accordingly, the RFID tag can operate stably even when the memory cassette for tissue specimens having the RFID tag attached thereto comes in contact with chemicals or is submerged in chemical solutions or water.
US08945481B1 Microfluidic devices and method for their use
Exemplary embodiments provide microfludic devices and methods for their use. The microfluidic device can include an array of M×N reaction sites formed by intersecting a first and second plurality of fluid channels of a flow layer. The flow layer can have a matrix design and/or a blind channel design to analyze a large number of samples under a limited number of conditions. The microfluidic device can also include a control layer including a valve system for regulating solution flow through fluid channels. In addition, by aligning the control layer with the fluid channels, the detection of the microfluidic devices, e.g., optical signal collection, can be improved by piping lights to/from the reaction sites. In an exemplary embodiment, guard channels can be included in the microfluidic device for thermal cycling and/or reducing evaporation from the reaction sites.
US08945478B2 Microfabricated devices with coated or modified surface and method of making same
A microfabricated device or component thereof, such as microfluidics or nanofluidics device having a uniform non-wetting or non-absorbing polymeric coating or surface modification formed on a surface thereof by ionization or activation technology such as plasma processing, to produce a surface energy of less than 15 mNm−1. The treatment enhances the free-flowing properties of a liquid through the device during use.
US08945473B2 Chemochromic detector for sensing gas leakage and process for producing the same
A chemochromic sensor for detecting a combustible gas, such as hydrogen, includes a chemochromic pigment and a textile polymer. The textile material includes a chemochromic pigment operably responsive to a combustible gas. The combustible gas sensing textile material can be made by melt spinning, solution spinning, or other similar techniques. In a preferred embodiment carbon nanotubes are used with the textile material which will increase the material strength and alter the thermal and/or electrical properties. These textiles woven into fabrics can provide garments not only with hydrogen sensing capabilities but the carbon nanotubes will allow for a range of sensing capabilities to be embedded (i.e. gas, health, and electronic monitors) within the garments.
US08945471B2 Multipurpose analysis using second harmonic generating nanoprobes
Second harmonic nanoprobes for multipurpose imaging of samples and a method of using such probes to monitor nucleotide sequencing in a Multi-SHG Detection Imaging (MSDI) modality and to monitor external electric field using voltage sensitive second harmonic generating (SHG) nanoprobes are provided. The SHG nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging for a wide-range of biological and non-biological processes and devices.
US08945469B2 Magnetic immunoassay system
A magnetic immunoassay system with a mechanism for compensating the direct current residual magnetic field in the vicinity of the specimen measurement position, in a direction perpendicular to the magnetic marker direction of magnetization for the measurement target. This invention reduces the effects of the magnetic field emitted from the unbound magnetic marker due to the residual magnetic field in the specimen solution and detects with high sensitivity the signal of the bound target magnetic marker. The magnetic field at the measurement position is regulated so as to intersect the direction of magnetization of the magnetic marker for the measurement target, in order to make the magnetization direction of the magnetic marker that is unbound due to residual magnetism or remanence in the sample solution, intersect the magnetization direction of the magnetic marker for the measurement target. The signal of the bound target magnetic marker can be therefore measured with high sensitivity since it is isolated from the unbound magnetic marker signal.
US08945468B2 Apparatus and method for sterilizing items
A sterilizing apparatus includes an enclosure defining an interior chamber and a door for accessing the interior chamber. A fluid source communicates with the chamber to supply a working fluid thereto. A heater heats the fluid in the chamber and a pump moves the fluid in the chamber by the heater. A valve communicates with the chamber and with the exterior of the chamber and is configured to vent the fluid in the chamber to the exterior at a pressure of approximately one atmosphere. Such provides superheating and concentrating of the working fluid in the chamber. A method of sterilization includes introducing a working fluid into an interior chamber and circulating the fluid through at least one recirculation loop having a heater for heating the fluid to an operational temperature suitable for killing microorganisms. The method further provides for killing of very high temperature resistant microorganisms.
US08945466B2 Composite material for heat dissipating plate and method of production of same
There is provided a composite material for a heat dissipating plate which achieves both a high thermal conductivity and a low coefficient of thermal expansion and has a performance satisfactory as a heat dissipating plate and a method of production of a composite material which can produce the composite material at a low cost. For this reason, powder metallurgy is used to produce the composite material for a heat dissipating plate. The composite material for a heat dissipating plate which is fabricated by this method of production contains an aluminum alloy and silicon carbide. The particles of silicon carbide are in contact with each other.
US08945465B2 Compressive rod assembly for molten metal containment structure
Exemplary embodiments of the invention relate to a compressive rod assembly for applying force to a refractory vessel positioned within an outer metal casing. The assembly includes a rigid elongated rod having first and second opposed ends, a threaded bolt adjacent to the first opposed end of the elongated rod, and a compressive structure positioned operationally between the elongated rod and the bolt. Compressive force applied by the bolt to the elongated rod passes through the compressive structure which allows limited longitudinal movements of the elongated rod to be accommodated by the compressive structure without requiring corresponding longitudinal movements of the bolt. Exemplary embodiments also relate to rod structure forming a component of the assembly, and to a metal containment structure having a vessel supported and compressed by at least one such assembly.
US08945461B2 Method for producing β-sialon phosphor
Provided is a production method of a β-sialon phosphor that europium ions are solid-solved in β-sialon, including a mixing process for mixing raw materials of the β-sialon phosphor; a burning process for burning the raw materials after the mixing process to form the β-sialon phosphor; a HIP treatment process in which the β-sialon phosphor after the burning process is subjected to a HIP treatment; an annealing process in which the β-sialon phosphor after the HIP treatment process is subjected to an annealing treatment; and an acid treatment process in which the β-sialon phosphor after the annealing process is subjected to an acid treatment. According to the production method of a β-sialon phosphor, a β-sialon phosphor excellent in luminescence intensity is obtained.
US08945457B2 Method and system for creating an apertured web-shaped material
A method for creating apertures with melted edges in a web shaped material including feeding a web-shaped material through a nip between a rotational ultrasonic horn and a rotational anvil roller, so as to create melted regions in the web-shaped material, while the web is residing on the anvil roller having a rotational speed. The method further includes controlling the rotational speed of the ultrasonic horn to a speed other than that of the anvil roller, such that a speed difference is created between the horn and the anvil roller. The speed difference is selected such that a stress created in the web acts to rupture the centers of the melted regions in the web-shaped material, whereby the apertures with melted edges are created.
US08945455B2 Reconfigurable shape memory polymer support tooling
A support apparatus and method for providing structural support to a shape memory polymer (SMP) apparatus during fabrication of composite parts. The support apparatus may comprise an adjustable, rigid structural member and a plurality of SMP support components transitionable between a rigid and malleable state and fixed to an outer surface of the rigid structural member. The rigid structural member may extend in at least one cross-sectional dimension toward the SMP apparatus, pressing the SMP support components, in their malleable state, against the SMP apparatus. The SMP support components may thereby conform to a first surface of the SMP apparatus, then return to their rigid state while pressed against the SMP apparatus, thus providing a rigid load path between the SMP apparatus and the rigid structural member. Then composite material may be applied to a second surface of the SMP apparatus, opposite of the first surface.
US08945454B2 Substrate manufacturing method, substrate manufactured by the substrate manufacturing method and magnetic recording medium using the substrate
Disclosed is a method for manufacturing a substrate provided with a surface portion having a plurality of concave and convex configurations. The method includes a step of applying a solution between a mold having a configuration corresponding to the concave and convex configurations, and a substrate base member, the solution obtained by dissolving a constructional material for composing the surface portion in a solvent; a step of forming the surface portion by drying the solvent in a state that the solution is applied between the mold and the substrate base member; and a step of releasing the mold from the surface portion. The mold satisfies requirements that a contact angle of a contact portion of the mold to be contacted with the solution is smaller than 90° with respect to the solvent, and that a work of adhesion between the contact portion and the constructional material is smaller than a work of adhesion between the contact portion and the solvent.
US08945451B2 Implantable medical electrical device connector module assemblies and methods
Methods for forming an insulative body of an implantable medical device connector module assembly employ an injection molding process, whereby first and second shots of insulative material form core and an overlay portions, respectively. In some methods, a panel portion of an electrical component is mounted between opposing surfaces of a mold such that a finger-like portion of the component extends into a cavity of the mold, with a first side thereof touching another surface of the mold and a second, opposite side exposed within the cavity; following first shot injection, the core portion captures the finger-like portion in relatively rigid relation thereto. When two types of connector bores are formed, a color indicator may be engaged with a feature of the core portion that is located in proximity to a connector bore of the first type, and then the overlay portion is formed over the indicator.
US08945442B2 Concrete formwork frame assembly and method of stripping concrete formwork from a concrete surface
This disclosure relates to a frame for use with formwork to support the formwork for concrete casting and for stripping formwork from a concrete surface. The formwork is secured to the frame assembly such that the level at which the formwork is supported by the framework is adjustable so as to be movable between at least a first level above a floor surface selected for concrete casting, and a second level where the formwork is either away from the cured concrete (i.e. stripped) or unsupported by the frame assembly. The disclosure provides a means of both supporting formwork during concrete casting as well as a means of stripping the formwork after the concrete is cast. An associated method is also disclosed.
US08945430B2 Photovoltaic cell containing a polymer electrolyte
A photovoltaic cell comprises a membrane electrode assembly obtainable by the in situ polymerization between two electrodes of one or more monomers to form a polymer, and then infusing an activating agent into the polymer, wherein the activating agent enables the membrane electrode assembly to function as a photovoltaic cell.
US08945429B2 Electrically conducting thin films and methods of making same
The present invention relates conductive nanostructured copolymer materials, such as thin film. In particular, the nanostructured copolymer material comprises plurality of chains substantially parallel to each other, each conductive chain comprising a plurality of conductive polyacetylene polymer blocks positioned along the chain and a plurality of polar poly(vinyl alcohol) polymer blocks in between the polyacetylene polymer blocks to form a pattern of alternatively repeating polyacetylene polymer blocks and poly(vinyl alcohol) polymer blocks and a ratio of polyacetylene polymer to poly(vinyl alcohol) polymer to provide the nanostructured copolymer material with conductivity of at least 1 S/cm. In some aspects, the invention relates to photoelectric devices comprising a nanostructured copolymer material and capable to convert light to electrical current.
US08945425B2 Semiconductor composition
An electronic device, such as a thin-film transistor, includes a semiconducting layer formed from a semiconductor composition. The semiconductor composition comprises a polymer binder and a small molecule semiconductor. The small molecule semiconductor in the semiconducting layer has a crystallite size of less than 100 nanometers. Devices formed from the composition exhibit high mobility and excellent stability.
US08945422B2 Method of operating ruthenium catalyst reactor
A catalytic reactor including: a reaction container filled with a catalyst having ruthenium; and an introduction part for introducing a material fluid to the reaction container. The reaction container is supplied with a mixed gas as material fluid to produce synthetic gas containing hydrogen and carbon monoxide in the presence of the catalyst. The introduction part is connected to the reaction container in a horizontal direction or a direction inclined downward from above a horizontal plane, and a height of the catalyst filled in the reaction container is adjusted above a height at which the material fluid is fed from the introduction part to the reaction container. Also, a method of using the catalytic reactor including monitoring a molar ratio of carbon and oxygen contained in the material fluid and stopping the supply of an oxygen-containing gas to the reaction container before the molar ratio becomes excessively low.
US08945419B2 Coated superabsorbent polymer particles and processes therefore
Superabsorbent material, comprising first superabsorbent polymers, coated with second clay-crosslinked superabsorbent polymers, said second clay-crosslinked superabsorbent polymers being obtainable by the step of polymerization of a solution/dispersion of polymerizable compounds and clay particles, to obtain said second superabsorbent polymers, crosslinked by said clay particles, of a weight average largest particle dimension of less than 800 nm.
US08945416B2 Laser processing method
A laser processing method of converging laser light into an object to be processed made of silicon so as to form a modified region and etching the object along the modified region so as to form the object with a through hole comprises an etch resist film producing step of producing an etch resist film resistant to etching on an outer surface of the object; a laser light converging step of converging the laser light at the object after the etch resist film producing step so as to form the modified region along a part corresponding to the through hole in the object and converging the laser light at the etch resist film so as to form a defect region along a part corresponding to the through hole in the etch resist film; and an etching step of etching the object after the laser light converging step so as to advance the etching selectively along the modified region and form the through hole.
US08945415B2 Method for etching a ceramic phosphor converter
A method is described for etching ceramic phosphor converters. The method includes contacting a surface of the converter with a solution of phosphor acid for a time sufficient to etch the converter. The method is applicable to ceramic phosphor converters comprising a phosphor having a general formula MxAlyOz:RE wherein M is a metal and RE is a rare earth element.
US08945414B1 Oxide removal by remote plasma treatment with fluorine and oxygen radicals
Oxides (e.g., native or thermal silicon oxide) are etched from underlying silicon with a mixture of fluorine and oxygen radicals generated by a remote plasma. The oxygen radicals rapidly oxidize any uncovered bare silicon areas, preventing the pitting that can result from fluorine etching bare silicon more rapidly than it etches the surrounding oxide. A very thin (few Å), highly uniform passivation layer remaining on the silicon after the process may be left in place or removed. An oxygen-impermeable layer may be formed in-situ immediately afterward to prevent further oxidation. A pre-treatment with oxygen radicals alone fills pores and gaps in the oxide before etching begins.
US08945409B2 Porous medium with increased hydrophobicity and method of manufacturing the same
The present invention provides a porous medium with increased hydrophobicity and a method of manufacturing the same, in which a micro-nano dual structure is provided by forming nanoprotrusions with a high aspect ratio by performing plasma etching on the surface of a porous medium with a micrometer-scale surface roughness and a hydrophobic thin film is deposited on the surface of the micro-nano dual structure, thus significantly increasing hydrophobicity. When this highly hydrophobic porous medium is used as a gas diffusion layer of a fuel cell, it is possible to efficiently discharge water produced during electrochemical reaction of the fuel cell, thus preventing flooding in the fuel cell. Moreover, it is possible to sufficiently supply reactant gases such as hydrogen and air (oxygen) to a membrane electrode assembly (MEA), thus improving the performance of the fuel cell.
US08945408B2 Etch process for reducing directed self assembly pattern defectivity
Provided is a method for preparing a patterned directed self-assembly layer, comprising: providing a substrate having a block copolymer layer comprising a first phase-separated polymer defining a first pattern in the block copolymer layer and a second phase-separated polymer defining a second pattern in the block copolymer layer; and performing an etching process to selectively remove the second phase-separated polymer while leaving behind the first pattern of the first phase-separated polymer on the surface of the substrate, the etching process being performed at a substrate temperature less than or equal to about 20 degrees C. The method further comprises providing a substrate holder for supporting the substrate, the substrate holder having a first temperature control element for controlling a first temperature at a central region and second temperature control element at an edge region of the substrate and setting a target value for the first and the second temperature.
US08945407B2 Touchless site isolation using gas bearing
A gas bearing seal using porous materials for distribution of gas flow can provide site isolation during wet processing. In some embodiments, a flow cell comprises a porous media gas bearing surrounding a periphery of the flow cell, isolating the liquid inside the flow cell from the ambient air outside the flow cell. In some embodiments, a protective chuck comprises a porous media gas bearing disposed in a middle of the protective chuck, isolating the liquid outside the protective chuck with the gaseous ambient generated by the porous media gas bearing.
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