Document Document Title
US08802967B2 Photoelectric conversion module
A photoelectric conversion module including a pair of substrates facing each other and forming a space for containing an electrolyte therein, a sealing member placed along the edges of the pair of substrates to seal the electrolyte, defining a plurality of photoelectric cells between the pair of substrates, and having an open portion to form an electrolyte inlet, and an inlet sealer formed along the electrolyte inlet. The photoelectric conversion module has improved durability, reliability, and mass-productivity.
US08802966B2 Methods and systems for light energy augmented power
A method for transmitting power over long distances to a remote device is described. The method includes positioning a lens between a photon source and a photon receiver, the lens, photon source and photon receiver being physically separate systems, focusing a plurality of photons originating from the photon source using the lens, collecting the photons at a receiver, and utilizing the collected photons to generate electrical power.
US08802965B2 Plasmonic nanocavity devices and methods for enhanced efficiency in organic photovoltaic cells
Plasmonic nanocavity arrays and methods for enhanced efficiency in organic photovoltaic cells are described. Plasmonic nanocavities offer a promising and highly tunable alternative to conventional transparent conductors for photovoltaic applications using both organic and inorganic materials systems.
US08802962B2 Foot actuated percussion board
The present invention is a device for use on a playing surface by a musician using a foot to generate an electrical signal indicative of a bass drum. The device generally comprises a body having a horizontally disposed base, a pivot body secured to the bottom surface of the base, and a strike body secured to the base. The pivot body is adapted to rest upon playing surface allowing body to pivot relative to the playing surface between a first position where the strike body is off the playing surface and a second position where the strike body hits or impacts the playing surface. The device further comprises electronic sensing circuitry adapted to generate an electrical signal indicative of a base drum in response to the strike body hitting the playing surface.
US08802958B2 Input device for an electronic system and methods of using same
Devices and methods for controlling an electronic system are provided. An embodiment of a device comprises a spring having a first end with a first handle and a second end with a second handle. A first sensor detects movement of the first end and a second sensor detects movement of the second end. Each sensor provides a control signal to the electronic system such that the electronic system can act according to the varying control signals. A method comprises providing a spring-based musical instrument and providing a computer having a speaker. The spring is altered by the musician in order to generate control signals to the computer. Sound is generated by the speaker and varied by the computer according to the received control signals.
US08802956B2 Automatic accompaniment apparatus for electronic keyboard musical instrument and fractional chord determination apparatus used in the same
The number of chords belonging to a first chord group is decreased to less than the number of chords belonging to a second chord group. In a first detection mode, when a first determining unit determines that a state of key depressed does not correspond to any chord in a first chord group, a previously selected chord is continuously determined. Accordingly, even if a chord detection is performed on a change of melody point by point, the number of chords substantially detected is decreased. This decreases the number of changes in accompaniment, thus stabilizing a playback of the accompaniment.
US08802955B2 Chord based method of assigning musical pitches to keys
Improvisation or playing along with a musical group or with a song is enjoyable to people and musicians of all ability levels. However, it is easy to play notes which do not harmonize with other notes and pitches which are being played. Provided herein is a method, computer program product and electronic device for assigning a set of pitches to a plurality of physical keys of an electronic device. The method may include the steps of obtaining an input chord, disassembling the chord into at least one base note and a plurality of individual voices, arranging a predetermined number of voices of the chord according to at least one predefined rule, and assigning at least one set of pitches to a plurality of physical keys of an electronic device, said set of pitches corresponding to the base note and arranged predetermined number of voices of the chord. The present method allows a musician to freely play along without the possibility of playing an errant note as the user does not control the actual pitch associated with the physical keys being played.
US08802954B2 System and method for controlling audio source
An apparatus for signal processing, wherein a disc is placed on a turntable and is provided with a groove which can be followed by the pick-up element, and employing a time-code signal wherein during use of the disc the said time-code signal controls the digital audio source.
US08802950B2 Harmonica
The harmonica according to the invention includes a comb or windchest supporting at least one reed plate on which are mounted sound reeds and a peripheral shell allowing to hold the harmonica, said shell including at least one cover plate. Each of its reed plates is sandwiched between the pressing face concerned of the comb and the corresponding cover plate by pressing means for bringing said cover plate closer to the comb between the mouthpiece face of the instrument and the pressing tabs on the side of the bell of the instrument.
US08802949B2 Pitch altering mechanism for reeded instrument
A system for altering the pitch produced by a reed of a reeded instrument. The system comprises a reed having a first portion structured to be coupled to the instrument and a second portion generally free to vibrate and a magnet adjustably disposed adjacent the reed. The reed comprises a magnetic material.
US08802947B1 Wheat variety W020852C1
A wheat variety designated W020852C1, the plants and seeds of wheat variety W020852C1, methods for producing a wheat plant produced by crossing the variety W020852C1 with another wheat plant, and hybrid wheat seeds and plants produced by crossing the variety W020852C1 with another wheat line or plant, and the creation of variants by mutagenesis or transformation of variety W020852C1. This invention also relates to methods for producing other wheat varieties or breeding lines derived from wheat variety W020852C1 and to wheat varieties or breeding lines produced by those methods.
US08802944B2 Variety corn line IH6506
The present invention provides an inbred corn line designated IH6506, methods for producing a corn plant by crossing plants of the inbred line IH6506 with plants of another corn plant. The invention further encompasses all parts of inbred corn line IH6506, including culturable cells. Additionally provided herein are methods for introducing transgenes into inbred corn line IH6506, and plants produced according to these methods.
US08802942B2 Variety corn line NPID7052
The present invention provides an inbred corn line designated NPID7052, methods for producing a corn plant by crossing plants of the inbred line NPID7052 with plants of another corn plant. The invention further encompasses all parts of inbred corn line NPID7052, including culturable cells. Additionally provided herein are methods for introducing transgenes into inbred corn line NPID7052, and plants produced according to these methods.
US08802940B2 Thin-skinned Chile pepper variety
An improved Anaheim-type chile pepper cultivar having a fruit characterized by a relatively thin skin in comparison to other Anaheim-type chile pepper cultivars, such that mechanized peeling of fruit results in an average recovery, excluding skin, seed, and placenta, that is at least 5% higher in comparison to the peeling of an existing Anaheim-type chile pepper cultivar. The improved cultivar further is characterized by a mature seed content of less than 20 pounds per 1000 pounds of fruit and by fruit that is readily de-stemmed by mechanized de-stemming.
US08802939B2 Hybrid pepper plants resulting from a cross between C. annuum and C. pubescens
The present invention relates to novel methods of producing interspecific hybrids between C. annuum and C. pubescens and progeny thereof. In addition, the present invention provides for the hybrid pepper plants, and parts thereof including their fruit, tissues, and seeds, resulting from a cross between C. annuum and C. pubescens that have nuclear genetic material from both C. annuum and C. pubescens. The hybrid pepper plants of the invention may have a variety of traits including resistance to geminiviruses, tobamoviruses, and resistance to damage by Xanthomonas.
US08802937B1 Soybean cultivar 21232
Disclosed is the seed of a novel soybean cultivar, designated 21232, a sample of which is deposited under ATCC Accession No. PTA-120876. Also disclosed are plants, or parts thereof, grown from the seed of the cultivar, plants having the morphological and physiological characteristics of the 21232 cultivar, and methods of using the plant or parts thereof in a soybean breeding program.
US08802936B2 Soybean variety A1035898
The invention relates to the soybean variety designated A1035898. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1035898. Also provided by the invention are tissue cultures of the soybean variety A1035898 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1035898 with itself or another soybean variety and plants produced by such methods.
US08802935B2 Plants and seeds of spring canola variety SCV942568
In an embodiment, the invention relates to the seeds, plants, and plant parts of canola line SCV942568 and to methods for producing a canola plant produced by crossing canola line SCV942568 with itself or with another canola line. The invention also relates to methods for producing a canola plant containing in its genetic material one or more transgenes and to the transgenic canola plants and plant parts produced by those methods. This invention also relates to canola lines or breeding lines and plant parts derived from canola line SCV942568, to methods for producing other canola lines, lines or plant parts derived from canola line SCV942568 and to the canola plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid canola seeds, plants and plant parts produced by crossing the line SCV942568 with another canola line.
US08802932B2 Antipathogenic proteins and methods of use
Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for family members of a novel family of antipathogenic polypeptides. Polynucleotides that encode the antipathogenic polypeptides are also provided. A method for inducing pathogen resistance in a plant using the polynucleotides disclosed herein is further provided. Compositions comprising an antipathogenic polypeptide or a microorganism comprising an antipathogenic polynucleotide of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Plants, plant cells, seeds, and microorganisms comprising an antipathogenic polnucleotide or polypeptide of the invention are also disclosed.
US08802931B2 Salt resistant transgenic plants
The present invention provides transgenic plants transformed with exogenous nucleic acid encoding a Dunaliella plasma membrane (PM)-ATPase. The transgenic plant has increased tolerance to salt as compared to a corresponding non-transgenic plant. The present invention also provides nucleic acids encoding a chimeric PM-ATPase, which comprise a first portion encoding a plant PM-ATPase or a fragment thereof, and a second portion encoding a Dunaliella PM-ATPase or a fragment thereof. The present invention also discloses a method of producing a transgenic plant having an increased tolerance to salt as compared to a corresponding non-transgenic plant, a method of modifying a plant capacity to survive salt shock, and a method of modifying plant recovery after exposure to salt stress, by introducing into one or more cells of a plant an exogenous nucleic acid encoding a Dunaliella PM-ATPase. Also provided by the present invention are plant cells comprising an exogenous nucleic acid encoding a Dunaliella PM-ATPase, and plant seeds and progeny obtained from the transgenic plants.
US08802927B2 Stress resistant plants
Stress tolerance in plants and plant cells is achieved by using nucleotide sequences encoding enzymes involved in the NAD salvage synthesis pathway and/or the NAD de novo synthesis pathway e.g. for overexpression in plants.
US08802926B2 Heat stable mutants of starch biosynthesis enzymes
The subject invention pertains to novel mutant polynucleotide molecules that encode enzymes that have increased heat stability. These polynucleotides, when expressed in plants, result in increased yield in plants grown under conditions of heat stress. The polynucleotide molecules of the subject invention encode maize endosperm ADP glucose pyrophosphorylase (AGP) and soluble starch synthase (SSS) enzyme activities. Plants and plant tissue bred to contain, or transformed with, the mutant polynucleotides, and expressing the polypeptides encoded by the polynucleotides, are also contemplated by the present invention. The subject invention also concerns methods for isolating polynucleotides and polypeptides contemplated within the scope of the invention. Methods for increasing yield in plants grown under conditions of heat stress are also provided.
US08802922B2 Nucleic acid constructs and methods for producing altered seed oil compositions
The present invention is in the field of plant genetics and provides recombinant nucleic acid molecules, constructs, and other agents associated with the coordinate manipulation of multiple genes in the fatty acid synthesis pathway. In particular, the agents of the present invention are associated with the simultaneous enhanced expression of certain genes in the fatty acid synthesis pathway and suppressed expression of certain other genes in the same pathway. Also provided are plants incorporating such agents, and in particular plants incorporating such constructs where the plants exhibit altered seed oil compositions.
US08802913B2 Reduction in flushing volume in an adsorptive separation system
A process for separating a product from a multicomponent feedstream to an adsorption apparatus or system is described. The apparatus or system may comprise a moving-bed or a simulated moving-bed adsorption means. The product comprises at least one organic compound, such as an aryl compound with alkyl substitutes. In embodiments the conduits used to supply the feedstream to the apparatus or system are flushed with media of multiple grades. The improvement is a more efficient use of the desorbent. In embodiments the process achieves improvements in one or more of efficiency of adsorption separation, capacity of adsorption apparatus systems, and purity of product attainable by adsorption process.
US08802910B2 Alkylation of aromatic substrates and transalkylation process
A process for the alkylation of an aromatic substrate can include providing an alkylation reaction zone containing an alkylation catalyst, and introducing a feedstock including an aromatic substrate and an alkylating agent into an inlet of the alkylation reaction zone and into contact with the alkylation catalyst. The alkylation reaction zone can be operated at temperature and pressure conditions to cause alkylation of the aromatic substrate in the presence of the alkylation catalyst to produce an alkylation product including a mixture of the aromatic substrate and monoalkylated and polyalkylated aromatic components. The alkylation product can be withdrawn from the alkylation reaction zone. Nitrogen containing compounds in the aromatic substrate, alkylating agent, or both can be monitored in a range 15 wppb to 35 wppm by dry colorimetry. The process can include transalkylation of polyalkylated aromatic components in a transalkylation reaction zone containing a transalkylation catalyst.
US08802909B2 Method for improving productivity and process stability in styrene manufacturing system having multiple reactors connected in series
A method for improving productivity and process stability in styrene monomer manufacturing system using a reaction system having multiple reactors connected in series, which can prevent destruction of the embedded catalyst and bending of a screen which supports catalyst and achieve homogeneous catalyst inactivation during the reaction by divergence of some portions of the feed containing steam and ethylbenzene and injection thereof into a certain point of the system.
US08802903B2 Stacked bed reactor with diluents for producing ethanol
The present invention relates to processes for producing ethanol using a stacked bed reactor comprising a first bed comprising a first hydrogenation catalyst and a second bed comprising a second hydrogenation catalyst and one or more diluents. The diluents may be selected from the group consisting of silica, silica-alumina and mixtures thereof.
US08802902B2 Pressure driven distillation for ethanol production and recovery from hydrogenation process
Recovery of alcohols, in particular ethanol, from a crude ethanol product obtained from the hydrogenation of acetic acid using pressure driven distillation to separate the crude ethanol product. The crude ethanol product may be fed to a distillations column in which a substantial portion of the water is removed with the acetic acid in the residue. A second column is at higher pressure than a first column.
US08802892B2 Functionalized phenolic compounds and polymers therefrom
The present invention relates to compounds of formula I, which are functionalized phenolic compounds, and polymers formed from the same. Ar—[O—(X)p—R′]q  I Polymers formed from the functionalized phenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
US08802891B2 Process for the manufacture of alkylamino alkylene phosphonic acids
A process for the manufacture of alkylamino alkylene phosphonic acids is disclosed. In detail, a specific phosphonate is reacted with an agent selected to yield an alkylamino moiety substituted by a radical selected from OH, OR′, NH2, NHR′, N(R′)2, NH, N, S, S—S and SH in aqueous alkaline medium having a pH of 8 or higher at a temperature of 0° C. or higher.
US08802889B2 Process for production of allyl acetate
A process for production of allyl acetate includes steps of reacting acetic acid 3, oxygen 1 and propylene 2 in the presence of a catalyst in an oxidation reactor 5 to form allyl acetate and water; separating the unreacted acetic acid by a distillation column 9; and recovering an acetic acid-containing liquid which contains acetic acid and returning the acetic acid-containing liquid to the oxidation reactor 5 via an acetic acid-water evaporator 4, the process further including a heating step of heating a process liquid which contains the acetic acid-containing liquid to a temperature of 80 to 250° C. by a heater.
US08802888B2 Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester HCl
The invention relates to a process for the preparation of trans 4-amino-cyclohexil ethyl acetate HCl wherein d) hydrogenating 4-nitrophenyl acetic acid in a protic solvent at a temperature between 40-50° C. in the presence of Pd/C under 0.1-0.6 bar overpressure, and e) further hydrogenating the 4-aminophenyl acetic acid obtained in situ in step a) at a temperature between 50-60° C. under 1-4 bar overpressures, then f) heating to reflux the 4-aminocyclohexil acetic acid obtained in step b) for 1-3 hours in hydrochloric ethanol, and if desired after removing the solvent acetonitrile was added to the residue obtained and distilled off.
US08802884B2 Process for producing aromatic carbonates
This invention provides a method for producing an alkylaryl carbonate comprising: a) contacting a stream comprising an aromatic hydroxy compound and a stream comprising a dialkylcarbonate in a reactive distillation column containing a bed of heterogeneous transesterification catalyst, the bed having a top and a bottom; and b) withdrawing a product stream comprising the alkylaryl carbonate from the reactive distillation column wherein the aromatic hydroxy compound is fed to the column at a first feed point located above the top of the catalyst bed.
US08802882B2 Composition and method for low temperature chemical vapor deposition of silicon-containing films including silicon carbonitride and silicon oxycarbonitride films
Silicon precursors for forming silicon-containing films in the manufacture of semiconductor devices, such as films including silicon carbonitride, silicon oxycarbonitride, and silicon nitride (Si3N4), and a method of depositing the silicon precursors on substrates using low temperature (e.g., <550° C.) chemical vapor deposition processes, for fabrication of ULSI devices and device structures.
US08802881B2 Benzo lipoxin analogues
Benzolipoxin analogs, methods of their preparation and pharmaceutical compositions containing the compounds are provided. The compounds and compositions are useful in methods for treatment of various diseases, including, inflammation, autoimmune disease and abnormal cell proliferation.
US08802879B2 Process for removal of metals from oils/fats
The invention describes process for demetallation of vegetable oils and animal fats to reduce metal content below 1 ppm to make them suitable for hydroprocessing feedstocks. The process comprises acid treatment with very low concentration of acids, utilizing synergistic effect of phosphoric acid and citric acid, followed by counter-current treatment with clay without intermediate step of water washing and treatment with ion exchange resin.
US08802878B2 Process for the production of fatty acid methyl esters from variable feedstock using heterogeneous catalysts
A process for producing fatty acid methyl esters includes mixing an alcohol with a feedstock oil to prepare an alcohol/oil mixture, then reacting the alcohol/oil mixture using a first heterogeneous catalyst in an acid esterification process to produce a glycerin-containing product. The glycerin is separated from the glycerin-containing product using a coalescer to produce a biodiesel-containing feedstock and glycerin. Biodiesel is separated from the biodiesel-containing feedstock using a coalescer to produce unreacted feedstock and biodiesel. The unreacted feedstock is reacted using a second heterogeneous catalyst in a trans-esterification process to produce a glycerin-biodiesel-methanol mixture. Biodiesel and glycerin are separated in separate streams from the glycerin-biodiesel-methanol mixture, using a coalescer, to produce additional glycerin and additional biodiesel.
US08802873B2 Process for the manufacture of epichlorohydrin
The invention relates to a process for the manufacture of epichlorohydrin (“ECH”) by catalytic oxidation of allyl chloride (“AC”) with an oxidant wherein the catalytic oxidation is performed in an aqueous reaction medium, wherein a water-soluble manganese complex is used as oxidation catalyst, followed by the isolation of epichlorohydrin.
US08802868B2 Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.
US08802866B2 Pyridinylimidazolone derivatives for the inhibition of PI3 kinases
Compounds of the formula (I), in which X1, X2, L, Y, R2, R3, R4, R5, R6, R7, R8, R9, R10 have the meanings indicated in claim 1, are PI3K inhibitors and can be employed, inter alia, for the treatment of autoimmune diseases, inflammation, cardiovascular diseases, neurodegenerative diseases and tumors.
US08802865B2 2-substituted benzimidazoles as selective androgen receptor modulators (SARMS)
The present invention is directed to a novel 2-substituted benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
US08802860B2 Method for producing substituted pyridin-2-one
The present invention relates to a process for the preparation of substituted 3-(2-hydroxyethyl)-1-[4-nitrophenyl]pyridin-2(1H)-ones which serve as important intermediate compounds for producing drugs.
US08802856B2 Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists
The invention provides compounds of formula I: in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R1-6, a-e and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
US08802851B2 Process for preparing vilazodone hydrochloride
The present invention relates, in a first aspect, to a process preparing vilazodone hydrochloride that comprises the reaction of 3-(4-chloro-1-hydroxy-butyl)-1H-indol-5-carbonitrile with 5-piperazin-1-yl-benzofuran-2-carboxylate methyl hydrochloride with the formation of a 1,4-piperazine, with subsequent dehydration, hydrogenation and treatment with ammonia, to obtain vilazodone in free base form that is then converted into the hydrochloride thereof.
US08802849B2 Tricyclic benzo[4,5]thieno-[2,3-d]pyrimidine-4-yl-amin derivatives, their salts, process for producing the compounds and their pharmaceutical use
The invention relates to novel tricyclic benzo[4,5]thieno-[2,3-d]pyrimidine-4-yl-amin derivatives, as well as their pharmaceutically acceptable salts. The subject of the invention too the process for producing the compounds and their use as a pharmaceutically active agent and as pharmaceutical compositions for prophylaxis and/or treatment of proliferative diseases such as cancer.
US08802848B2 Melamine based mannich-compounds and a process for obtaining the same
The present invention relates to Melamine based Mannich compounds of the general formulae (1)-(12) and a process for synthesizing melamine based Mannich-products comprising the steps of a) reacting at least one substituted melamine with at least one aldehyde, in particular formaldehyde, under basic conditions to form at least one OH-containing compound, b) reacting the at least one OH-containing compound in the presence of a catalyst to form at least one mannich-base, c1) reacting the at least one mannich-base with at least one enol-forming carbonyl compound, or c2) reacting the at least one mannich-base with at least one aromatic compound, and d) working up the reaction mixture. The invention relates further to precondensates obtainable from these products.
US08802843B2 Tagatose production using simulated moving bed separation
Disclosed is a process for the production of d-tagatose from lactose after acid hydrolysis to provide a hydrolysate having 1 equiv of d-glucose and 1 equiv of d-galactose for each unit of lactose converted. More particularly, the invention relates to a process for the isomerization of d-galactose to d-tagatose and the use of a simplified separation scheme based on simulated moving bed (SMB) separation. The isomerization of d-galactose to d-tagatose is carried out in the presence of calcium oxide or calcium hydroxide. The process is useful for providing a simplified processing route to providing pure d-tagatose and glucose as two products from lactose hydrolysate. In an alternate embodiment, a process is disclosed for the production of d-tagatose from fermented lactose hydrolysate to provide a crystallized d-tagatose product. D-tagatose is useful as a food additive, as a sweetener, as a texturizer, as a stabilizer, or as a humectant.
US08802842B2 Method for the preparation of a crystalline form
The invention relates to a method for the preparation for a crystalline form of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene. In addition the invention relates to a crystalline form obtainable by this method, to a pharmaceutical composition and to the use thereof for preparing medicaments.
US08802841B2 1,2-dideoxy-1,2-diamino oligosaccharides and polysaccharides and derivatives thereof
A 1,2-dideoxy-1,2-diamino oligosaccharide or polysaccharide in its free base, salt or metal-complex form as shown in General Formula 1 and derivative thereof is described. R1, R2 and R3 are each independently selected from the group consisting of H and a carbohydrate moiety, with the proviso that at least one of the groups R1, R2 or R3 is a carbohydrate moiety; R4 is selected from the group consisting of: H, optionally substituted C1-20-alkyl, optionally substituted heteroalkyl, optionally substituted C2-20-alkenyl, optionally substituted C2-20-alkynyl, optionally substituted C3-10-cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl.
US08802839B2 Connective tissue growth factor antisense oligonucleotides
The present invention relates to antisense oligonucleotides that target human CTGF mRNA and inhibit CTGF mRNA expression. Additionally, regions of human CTGF mRNA that are exceptionally sensitive to antisense inhibition are disclosed. Pharmaceutical compositions comprising the antisense oligonucleotides are further disclosed. These compositions are useful for treating disorders and conditions that are associated with or influenced by CTGF expression.
US08802830B2 Synthesis of epirubicin from 13-dihydrodaunorubicine
A method of preparing an anthracyclin such as epirubicin from a starting material comprising 13-dihydrodaunorubicine (13-daunorubicinol). The method comprises producing N-Trifluoroacetyl-13-daunorubicinol from 13-daunorubicinol by acylation. The N-Trifluoroacetyl-13-daunorubicinol is reacted with an aprotic solvent and an acylating agent to produce an intermediate sulfoxy salt which is treated with a strong base to produce 4′-keto-N-Trifluoroacetyldaunorubicin. The 4′-keto-N-Trifluoroacetyldaunorubicin is reacted with a reducing agent, such as borohydride of an alkaline metal, to produce N-Trifluoroacetyl-4′-epi-daunorubicin. The N-Trifluoroacetyl-4′-epi-daunorubicin is hydrolyzed in a basic solution to produce an intermediate compound. The intermediate compound is reacted with a halogenizing agent to produce a 14-Hal-derivative. The 14-Hal derivative is hydrolized in the presence of a formate of an alkaline metal to produce the desired final compound.
US08802829B2 Rinsable dyes and methods for their preparation
Rinsable dyes with improved fugitivity are formulated by attaching dyestuff compounds with amine-capped sulfonic solubilizing groups to commercially available ethoxylated aniline, so that the surfactant effect of the ethoxylated aniline counteracts the substantivity of the dyestuff compound, while the neutralization of the sulfonic solubilizing groups reduces substantivity.
US08802822B2 Polypeptides having antiviral activity and methods for use thereof
A polypeptide is provided that comprises an actinohivin variant polypeptide having an amino acid sequence selected from SEQ ID NOS: 4-12. The polypeptide can be provided as part of a fusion protein that includes the actinohivin variant polypeptide and either a fragment crystallizable domain of an antibody (Fc), a fragment antigen-binding domain of an antibody (Fab), or a single chain variable fragment of an antibody (scFv). Isolated nucleic acid molecules encoding the polypeptides are also provided along with vectors and plant cells capable of expressing the polypeptides. Methods of treating an infection of a subject by an enveloped virus are further provided and include administering an effective amount of the polypeptides to a subject.
US08802820B2 Fc variants with altered binding to FcRn
The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.
US08802819B2 Diketopiperazine forming dipeptidyl linker
The invention relates to a method for homogeneous solution phase peptide synthesis (HSPPS) of a N-terminal peptide fragment PEP-N and a C-terminal peptide fragment C-PEP, with C-PEP carrying a specific diketopiperazine (DKP) comprising C-terminal protecting group, which contains a handle group HG, with HG being connected to the C-terminus of the peptide fragment; thereby this specific DKP comprising C-terminal protecting group can be selectively cleaved from the peptide as a conventionally used C-terminal protecting group. By the use of this DKP and HG comprising C-terminal protecting group, certain process steps in convergent peptide synthesis based on a combination of HSPPS and solid phase peptide synthesis (SPPS) can be avoided. The invention relates further to a method for the preparation of such specifically protected fragment C-PEP by SPPS by using a linker comprising a specific dipeptide and HG for connecting the growing peptide chain to the resin, which linker forms said DKP group, when the peptide fragment C-PEP is cleaved from the supporting resin; and further to the intermediates of the preparation method.
US08802809B2 Method of production of cast polyamides
The present invention relates to a new method of production of cast polyamides.
US08802806B2 Two-component sealant comprising cross-linked polyalkylene oxide
The present invention relates to a two-component sealant comprising a first part and a second part wherein a) the first part (X) comprises: (i) a polyalkyleneoxide polymer having one or more unsaturated end groups (ii) an addition reaction catalyst b) the second part (Y) comprises: (i) an organosiloxane comprising one or more Si—H groups. The present invention also relates to medical devices used in connection with the sealant, mixing devices for delivering and mixing the first part and the second part of the sealant, and methods for applying the sealant.
US08802804B2 Hydroxy-terminated siloxane, polysiloxane-polycarbonate copolymer, and preparation method thereof
Provided are a hydroxy-terminated siloxane, a polysiloxane-polycarbonate copolymer including same as a repeating unit, and a preparation method thereof. The hydroxyl-terminated siloxane has the structure of chemical formula 1.
US08802803B2 Polyethylene for rotomoulding
A novel polyethylene is devised which polyethylene is particularly advantageous for manufacturing rotomoulded articles.
US08802800B2 Production method for water-absorbent resin
A production method for a water-absorbent resin, comprising a polymerization step for obtaining hydrogel by subjecting a monomer aqueous solution to a polymerization reaction, and a drying step for drying the hydrogel, wherein drying in the drying step is performed using a continuous through-flow belt-type drying machine, the pore opening rate of the through-flow belt in the continuous through-flow belt-type drying machine is 20 to 50%, the solid content of the hydrogel supplied to the drying step is 35% by weight or more, and the area occupancy rate of the hydrogel is 85 to 100% relative to the through-flow belt.
US08802794B2 Interlock and process
Interlock for use in a process for degassing of a polymer powder in a degassing vessel. The interlock includes the steps of 1. measuring the temperature of the polymer powder within or exiting the degassing vessel, 2. comparing the measurement value to a threshold value in order to ascertain whether it is lower than the threshold value or not, and 3. if the measured temperature is lower than the threshold value taking one or more actions to reduce the concentration of hydrocarbons in the polymer powder exiting the degassing vessel and/or to stop the polymer powder withdrawal from that degassing vessel.
US08802789B2 Polybenzimidazole-polyetherketoneketone blends and miscible blends
A process for producing a solution blend of a polybenzimidazole (PBI) and a polyetherketoneketone (PEKK). The PBI is mixed with sulfuric acid at a temperature between 40° C. and 80° C. for 30 minutes to 2 hours to produce a PBI solution then cooled to room temperature to form a cooled PBI solution. Then PEKK is added to the cooled PBI solution to form a mixture and that mixture is stirred from 30 minutes to 2 hours at room temperature to form a stirred mixture. The stirred mixture is poured into an excess of water being stirred swiftly to form an aqueous mixture. The aqueous mixture is filtered to produce a blend. The blend is washed with water and dried. The resulting blend can yield a blend in all proportion from 1/99 PBI/PEKK to 99/1 PBI/PEKK.
US08802787B2 Bromination of low molecular weight aromatic polymer compositions
Described is process technology for producing brominated aromatic polymer compositions from low molecular weight aromatic polymer compositions. The specified conditions used in the process enable the formation of products having superior color and thermal stability properties.
US08802786B2 Particulate superabsorbent polymer composition having improved performance properties
The present invention relates to a particulate superabsorbent polymer composition which absorbs water, aqueous liquids, and blood, and a process to make the superabsorbent polymers, wherein a superabsorbent polymer is surface treated with a neutralized multivalent metal salt solution having a pH value similar as that of human skin. The present invention also relates to particulate superabsorbent polymer composition having high Gel Bed Permeability and high Absorbency Under Load.
US08802782B2 Modified polyolefins with an exceptional profile of properties, process for preparation thereof and use thereof
Modified polyolefins with syndiotactic structural elements and a processes for preparation thereof are provided. The modified polyolefins are useful as an adhesive or as a constituent of adhesives.
US08802779B2 Propylene-based polymer composition, use thereof, and method for producing thermoplastic polymer composition
The propylene-based polymer composition of the present invention includes 41 to 95 parts by weight of a propylene-based polymer (A) having a Tm measured by DSC of not less than 120° C. and not more than 170° C., and 59 to 5 parts by weight (provided that the total of (A) and (B) is 100 parts by weight) of a propylene/ethylene/α-olefin copolymer (B) that contains 84.0 to 60.0 mol % of constitutional units derived from propylene, 15.0 to 30.0 mol % of constitutional units derived from ethylene, and 1.0 to 10.0 mol % of constitutional units derived from an α-olefin having 4 to 20 carbon atoms and has a B-value of not less than 0.9 and not more than 1.5. This polymer composition is excellent in transparency, low-temperature impact resistance, and mechanical properties (flexibility or rigidity, etc.) and also excellent in heat resistance.
US08802776B2 Epoxy resin composition, method for producing composite unit using the epoxy resin composition, and composite unit
An epoxy resin composition having excellent connection reliability and transparency, a method for manufacturing a composite unit using the epoxy resin composition, and the composite unit, are disclosed. The manufacturing method includes an attaching step of attaching an epoxy resin composition (2) containing a novolak phenolic curing agent, an acrylic elastomer composed of a copolymer containing dimethylacrylamide and hydroxylethyl methacrylate, an epoxy resin and not less than 5 parts by weight to not more than 20 parts by weight of an inorganic filler to 100 parts by weight of the epoxy resin, to a printed circuit board (1) in the form of a sheet. The manufacturing method also includes a temporary loading step of temporarily loading a semiconductor chip (3) and capacitors (4a) to (4d) on the epoxy resin composition (2) and an ultimate pressure bonding step of pressuring the semiconductor chip (3) and capacitors (4a) to (4d) by a thermal bonding head (20) in situ to ultimately pressure bond the semiconductor chip (3) and capacitors (4a) to (4d).
US08802767B2 Redispersible polymer powder from polyolefin dispersions and the use thereof in construction applications
The present invention provides compositions comprising redispersible polymer powders of polyolefins with carboxyl group containing dispersant polymers and vinyl ester copolymers which may further comprise hydraulic or water curable inorganic cements for various construction applications, such as cement tile adhesives. Methods of making redispersible polymer powders of polyolefins are also provided, including forming an aqueous polyolefin dispersion, such as, for example, by mechanical dispersion, followed by drying to form the redispersible polymer powders.
US08802763B2 Curable organopolysiloxane composition and semiconductor device
A curable organopolysiloxane composition in grease or paste form, which including: (A) an organopolysiloxane having at least two alkenyl groups bonded to silicon atom in one molecule; (B) an organohydrogenpolysiloxane having at least two hydrogen atoms bonded to silicone atom in the molecule; (C) gallium and/or a gallium alloy having a melting point of 0 to 70° C.; (D) a thermally conductive filler having an average particle size of 0.1 to 100 μm; (E) a platinum-based catalyst; and (F) a polysiloxane of the following general formula (1): wherein R1 may be the same or different and represents a monovalent hydrocarbon group, R2 represents an alkyl group, an alkoxyl group, an alkenyl group or an acyl group, a is an integer of 5 to 100, and b is an integer of 1 to 3.
US08802761B2 π-conjugated polymer composition
A π-conjugated polymer composition including:(a) a solvent; (b) a π-conjugated polymer which is dissolved in the solvent and doped with a dopant; (c) at least one of an acidic substance and a salt of an acidic substance; and (d) a phenolic compound; wherein when only the acidic substance is contained as the component (c), the acidic substance is different from the phenolic compound, when only the salt of an acidic substance is contained, the salt of an acidic substance is different from the phenolic compound, and when both the acidic substance and the salt of an acidic substance are contained, at least one of the acidic substance and the salt of an acidic substance is different from the phenolic compound.
US08802758B2 Polycarbonate resin composition and formed product thereof
In a polycarbonate resin composition containing a polycarbonate resin and a polycarbosilane compound, the use of the polycarbosilane compound modifies the surface properties of the polycarbonate resin composition without adversely affecting the intrinsic characteristics of the polycarbonate resin, such as transparency, heat resistance, and mechanical properties, e.g., impact resistance. A polycarbonate resin composition containing 100 parts by mass of a polycarbonate resin, 0.001 to 1 part by mass of a metal salt compound, and 0.005 to 5 parts by mass of a polycarbosilane compound has significantly improved flame resistance and high transparency and causes markedly reduced outgassing and mold fouling, without losing impact resistance and heat resistance.
US08802757B2 Viscosity regulating composition
A viscosity regulating composition having a polymeric structure with an internal hydrophobic unit located within the polymer's backbone, multiple hydrophilic units, and terminal hydrophobic units. In one embodiment, the internal hydrophobic unit may have at least three linked hydrophobic segments, of the same or different hydrophobic segments, with the proviso that the multiple hydrophobic segments are not linked to each other by one or more hydrophilic linking segments, for example water-soluble, polymeric groups.
US08802750B2 Reduced density opaque coatings and aerospace vehicles at least partially coated therewith
Disclosed are reduced density coating compositions and articles, such as aerospace vehicles, at least partially coated with an opaque coating deposited from such compositions. The reduced density coating compositions include low density microspheres comprising a core and a solid opacifying coating covering a surface of the core.
US08802748B2 Graft polymer mixture
A graft polymer mixture comprising a grafting base based on brown coal and/or polyphenol is proposed, which has, as a graft component, a copolymer consisting of one or more ethylenically unsaturated monomers different from one another and one or more polyamides different from one another. Typical grafting bases are brown coal, brown coal coke, lignite and brown coal derivatives and tannins. Suitable graft components are in particular vinyl-containing components and styrenes, which may also be present in sulphonated form. Natural polyamides, such as, for example, casein, gelatin and collagen, are suitable polyamide components. These graft polymers having a preferred molar mass Mn>5000 g/mol are suitable as a mixture, in particular in construction chemistry applications, and in the development, exploitation and completion of underground mineral oil and natural gas deposits, and in deep wells, since they have excellent salt and temperature stabilities and are simultaneously water-soluble and/or biodegradable.
US08802747B2 Nanoimprint lithography processes for forming nanoparticles
A lithography method for forming nanoparticles includes patterning sacrificial material on a multilayer substrate. In some cases, the pattern is transferred to or into a removable layer of the multilayer substrate, and functional material is disposed on the removable layer of the multilayer substrate and solidified. At least a portion of the functional material is then removed to expose protrusions of the removable layer, and pillars of the functional material are released from the removable layer to yield nanoparticles. In other cases, the multilayer substrate includes the functional material, and the pattern is transferred to or into a removable layer of the multilayer substrate. The sacrificial layer is removed, and pillars of the functional material are released from the removable layer to yield nanoparticles.
US08802746B2 Isocyanate-based foam having improved anti-yellowing properties and process for production thereof
There is described an isocyanate-based polymer foam having improved anti-yellowing properties. The foam produced from a formulation comprising an isocyanate, a blowing agent, a first active hydrogen-containing compound and a second active hydrogen-containing compound different than the first active hydrogen-containing compound. The second active hydrogen-containing compound comprises an active hydrogen-containing phosphite compound. A process for producing such a foam is also described.
US08802744B2 Alkyl carbonate endcapped polyether siloxanes and preparation thereof
The present invention provides polysiloxane-polyether copolymers comprising at least one polyether moiety, characterized in that there is at least one polyether moiety capped with at least one —O—C(O)—O—R″ unit where R″ is identical or different alkyl moieties, a process for preparation thereof and use thereof, especially for polyurethane foam production.
US08802743B2 Azeotrope-like compositions comprising trans-1-chloro-3,3,3-trifluoropropene
An azeotrope-like mixture consisting essentially of chlorotrifluoropropene and at least one component selected from the group consisting of pentane, hexane, methanol, and trans-1,2-dichloroethene.
US08802740B2 Environmentally friendly demulsifiers for crude oil emulsions
The present invention provides environmentally friendly demulsifiers for the breakdown of petroleum oil applications. The demulsification formulations of the present invention are biodegradable and are low in toxicity. The demulsifiers include a poly(tetramethylene glycol) and an alkylene glycol copolymer linked to the poly(tetramethylene glycol) by a difunctional coupling agent.
US08802739B2 Defoaming agents and articles and methods using same
Disclosed are low VOC defoaming agents comprising at least one active defoaming compound or combination of defoaming compounds, and a liquid carrier comprising one or more organic compounds having a viscosity of less than about 100 centistokes (cSt) at 40° C. as measured by ASTM D445, having a VOC content as measured by ASTM method D3960 “Standard Practice for Determining Volatile Organic Compound (VOC) Content of Paints and Related Coatings” of not greater than about 1% by weight.
US08802738B2 Polyesters with grafted zwitterions
The invention relates to polymers, such as aliphatic polyesters, with grafted zwitterions. More particularly, the invention relates to polyester-graft-phosphorylcholine polymers prepared by ring-opening polymerization and click chemistry, compositions and products comprising same, and related methods and uses, for example, in drug delivery.
US08802737B2 Method for improving tetracycline-resistance of Acinetobacter baumannii
A method for improving tetracycline-resistance of A. baumannii, by providing a ginger compound combined with tetracycline to against A. baumannii infection, wherein the ginger compound comprises [6]-dehydrogingerdione, [6]-shogaol and [6]-gingerol or [10]-gingerol, [6]-shogaol and [6]-gingerol.
US08802734B2 Method of treating or preventing pain
Compounds for use in the treatment or prophylaxis of pain, including acute and chronic pain (e.g., nociceptive pain, neuropathic pain, headaches, migraine), represented by general formula I: in which: the dotted line represents a single or a double bond; and R5 and R5′ are independently —H, —OH or —OR6, where R6 is a linear or branched C1-C4 alkyl; X is —CH2O—; Z is —CH2CH2O—, —CH(CH3)CH2O— or —CH2CH(CH3)O—; m is 1; and n is an integer of 1-5. The compounds of the invention are also effective for reducing inflammation and may be used alone or in combination with other analgesics.
US08802733B2 Aldehyde dehydrogenase inhibitors as novel depigmenting agents
The present invention provides methods and compositions for reducing pigmentation.
US08802731B2 N-acetyl beta alanine methods of use
Methods for increasing athletic performance, preventing paresthesia, increasing beta alanine absorption and cell membrane permeability through both passive diffusion and active transport, and increasing the half-life of beta alanine present in a blood stream in a human or animal are disclosed. Each method includes administering to the human or animal a pharmaceutically effective amount of N-Acetyl Beta Alanine or an N-Acetyl Beta Alanine composition.
US08802729B2 Enzyme stabilized detergent compositions
Biodegradable detergent compositions comprising enzymes and 1,3-propanediol are provided. The 1,3-propanediol in the composition is biologically derived and enhances the stability of the enzymes in the composition. The compositions also exhibit a low anthropogenic CO2 emission profile.
US08802727B2 Pharmaceutically acceptable salts of betulinic acid derivatives
The present invention relates to certain novel salts of Betulinic acid derivatives, to process for preparing such compounds, to use the compounds in treating diseases or disorders mediated by HIV infection, to methods for their therapeutic use and to pharmaceutical compositions containing them.
US08802725B2 Transition metal complexes of a bis[thiohydrazine amide] compound
The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.
US08802723B2 Metabolic syndrome-improving agent and medicine, supplement, functional food and food additive containing the same
A metabolic syndrome relieving agent that is free from a problem of side effects and can be taken for a long term is provided. Aurapten is used as an agent for relieving a metabolic syndrome. Since aurapten has functions of activating PPARα and PPARγ, promoting the secretion of adiponectin in adipocytes and inhibiting the generation of VLDLs in hepatic cells, it is possible to prevent or treat diseases such as insulin resistance, hyperinsulinism, type 2 diabetes, obesity, visceral fat obesity, hypertension, hyperlipemia, arteriosclerosis and the like and thus prevent or treat the metabolic syndrome. Also, as understood from the fact that citrus fruits such as a hassaku orange, a sweet summer orange or the like containing aurapten have been eaten for many years, they have no problems in terms of safety and have a low calorie content, and therefore, they can be taken for a long term. Further, since aurapten is tasteless and odorless, it does not impair the unique taste of a food when added to this food, so that it can be added to foods and taken.
US08802719B2 Method of preparing (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
Methods of preparing (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid are disclosed. Also provided are pharmaceutical compositions comprising (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid, and methods of treatment using such compositions.
US08802717B2 Methods of treating arthritic conditions using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline 1,3-dione
Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (−) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4.
US08802716B2 IAP binding compounds
IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPB (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in cells treated with such molecules. Embodiments of these compounds have a Kd of less than 0.1 micromolar. Methods of using these IAP binding molecules for therapeutic, diagnostic, and assay purposed are also disclosed.
US08802711B2 TRPV1 antagonists
Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates, or combinations thereof, wherein X1, X2, X3, X4, J, K, L, X5, X6, Rb, G2, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
US08802709B2 Crystalline forms of an alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid
The invention provides crystalline salt forms of 4′-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoylamino)methyl]-imidazol-1-ylmethyl}-3′-fluorobiphenyl-2-carboxylic acid. This invention also provides pharmaceutical compositions comprising the crystalline compounds, processes and intermediates for preparing the crystalline compounds, and methods of using the crystalline compounds to treat diseases such as hypertension.
US08802708B2 Agricultural or horticultural bactericide composition and method of controlling plant disease
The present invention provides a fungicide composition having stable and high harmful bio-organism control effect on crop plants infected with plant diseases due to plant diseases. Specifically, the present invention provides a fungicide composition for agricultural or horticultural use, which comprises: (a) an indole compound represented by formula (I): wherein R1 and R2 each independently represents C1-4 alkyl, etc.; Y represents H, halogen, etc.; R3 and R4 each independently represents a hydrogen atom, alkyl, etc.; R5, R6, R7 and R8 each independently represents a hydrogen atom, alkyl, etc., and (b) at least other fungicide selected from the group consisting of Dimethomorph, Chlorothalonil, a copper compound, Iprovalicarb, Zoxamide, phosphorous acid or a salt thereof, Fluazinam, Cyazofamid, Flumorph, Benthiavalicarb-isopropyl, Ethaboxam, Methalaxyl-M and Benalaxyl-M.
US08802702B2 Compounds for reducing drug resistance and uses thereof
This invention provides compounds capable of reducing drug resistance in a subject undergoing cancer treatment, methods using the compounds, compositions, and methods for identifying such compounds.
US08802694B2 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetycholine receptor ligands
The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
US08802693B1 Azaadamantane derivatives and methods of use
An embodiment relates to a nicotinic acetylcholine receptor ligand, a therapeutically suitable salt, prodrug, or a metabolite thereof, for the prevention and treatment of diseases and conditions that are mediated by nicotinic acetylcholine receptors, and methods of use thereof. Another embodiment is a method of administering a pharmaceutically effective amount of a nicotinic acetylcholine receptor ligand, a therapeutically suitable salt, prodrug, or a metabolite thereof, to a mammal in need thereof.
US08802692B2 Synergistic effects between sphingosine-1-phosphate receptor antagonists and antimicrotubule agents
This invention is based on the discovery that the administration of a sphingosine-1-phosphate receptor antagonist (S1P) and at least one chemotherapeutic agent selected from the the group of antimicrotubule agents provides an unexpectedly superior treatment for cancer. Antimicrobial agents such as the taxane compounds are known in the art, for example, paclitaxel (available as TAXOL® from Bristol-Myers Squibb, Princeton, N.J.), docetaxel (available as TAXOTERE® from Sanofi-aventis, Bridgewater, N.J.) and the like and other compounds that act as antimicrotubule agents, such as Vincristine (ONCOVIN®, VINCASAR PFS®, VCR), Vinblastin (VELBAN®, VELSAR®) and Vinorelbine, and similar compounds. The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of at least one sphingosine-1-phosphate 1 (S1P1R) receptor antagonists, and at least one antimicrotubule agent.
US08802691B2 Domperidone at a low daily dose for use in the treatment or prevention of a disease associated with an alteration of the immune response
The invention relates to the use of domperidone or a pharmaceutically acceptable salt thereof at low doses to prevent and/or treat a disease associated with an alteration of the immune response such as Leishmaniosis.
US08802689B2 Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.
US08802686B2 Sulfone-substituted anilinopyrimidine derivatives as CDK inhibitors, the production thereof, and use as a medicine
The invention relates to sulphone-substituted anilinopyrimidine derivatives of the formula (I), to its preparation processes, and to its use as medicament for treating various diseases.
US08802685B2 Solid forms of 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses
Solid forms comprising 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their uses are disclosed.
US08802683B2 Compounds for use in treatment of mucositis
The present invention provides methods for treating and/or preventing mucostitis with one or more compounds, or pharmaceutically acceptable salts thereof, disclosed herein, or compositions comprising the same.
US08802682B2 Compound useful for the treatment of degenerative and inflammatory diseases
A pyrazolopyridine compound according to Formula I, able to inhibit JAK is disclosed, as well as pharmaceutically acceptable salts, a solvate thereof, solvates of the pharmaceutically acceptable salts and biologically active metabolites thereof. The compound may be prepared as a pharmaceutical composition, and may be used for the treatment or prophylaxis of a variety of conditions in mammals including humans, and particularly, such conditions as may be associated with aberrant JAK activity, including by way of non-limiting example, allergy, inflammatory conditions, autoimmune diseases, proliferative diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6.
US08802679B2 Glycine compound
Compounds of formula (I) defined herein exhibit VAP-1 inhibitory activity, and as a result, are useful for preventing and/or treating VAP-1-related diseases, in particular, diabetic nephropathy or diabetic macular edema, thereby completing the present invention.
US08802670B2 Pharmaceutical compounds
Compounds of Formulae Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
US08802669B2 Dihydropyrimidine compounds and preparation methods, pharmaceutical compositions and uses thereof
Disclosed are dihydropyrimidine compounds and preparation methods, pharmaceutical compositions and uses thereof. Specifically, the compounds described herein in general formula (I), or their isomers, pharmaceutically acceptable salts or hydrates are provided, wherein each variable has the meaning as defined in the description. Also provided are a process for preparing the compounds of the general formula (I), the use of the compounds, an isomer thereof, a pharmaceutically acceptable salt thereof or a hydrate thereof as a medicament, in particular as a medicament for the treatment and/or prevention of Hepatitis B.
US08802668B2 Hematopoietic neoplasm chemotherapy
A method and medicament for treating mixed lineage leukemia; translocated mixed lineage leukemia; translocated mixed lineage leukemia based acute myelogenous leukemia; translocated mixed lineage leukemia based acute lymphoid leukemia; a non-MLL based chronic myeloproliferative disorder, or non-MLL based acute lymphoid leukemia is provided.
US08802667B2 Benzodiazepine derivatives
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
US08802662B2 Anti-hepatitis C composition and method for preparing drug for inhibiting hepatitis C viruses or treating hepatitis C
The invention provides an anti-hepatitis C composition including: an effective amount of limonoid compound, wherein the structure of the limonoid compound is shown as Structure (I): where R1 comprises H or OAc and R2 comprises H or COCH(CH3)2; and a pharmaceutically acceptable carrier or salt, and the anti-hepatitis C composition is used for inhibiting hepatitis C virus or treating hepatitis C. The invention also provides a method for treating hepatitis C and a method for preparing a drug for inhibiting hepatitis C viruses or treating hepatitis C.
US08802661B2 C-28 amides of modified C-3 betulinic acid derivatives as HIV maturation inhibitors
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 and C-28 betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.
US08802660B2 De novo synthesis of glucocorticoids in the epidermis and its uses and applications
The present invention relates to methods and compositions that control, i.e., antagonize/inhibit or agonize/stimulate, de novo glucocorticoid production in the skin. Such methods and compositions can be used for the prevention and/or treatment of a variety of skin conditions, including inflammation, acute wounds, chronic non-healing wounds, keloid, fibrotic or hypertrophic scars, and epithelial-derived cancer.
US08802659B2 Bicyclic aryl sphingosine 1-phosphate analogs
Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
US08802657B2 Compounds useful as Raf kinase inhibitors
The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
US08802655B2 4-hydroxybenzomorphans
4-Hydroxybenzomorphans containing carboxamide or thiocarboxamide at the 3-position are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. A compound of formula is disclosed, as are pharmaceutically acceptable acid addition salts, such as acetic, benzenesulfonic (besylate), benzoic, camphorsulfonic, citric, ethenesulfonic, fumaric, gluconic, glutamic, hydrobromic, hydrochloric, isethionic, lactic, maleic, malic, mandelic, methanesulfonic, mucic, nitric, pamoic, pantothenic, phosphoric, succinic, sulfuric, tartaric acid or p-toluenesulfonic acid salts. These compounds are useful for the treatment of pain.
US08802654B2 Antiviral compounds
Herein are disclosed novel compounds according to Formula (I) and aggregates comprising such compounds. These aggregates are useful to treat and prevent ocular infections caused by a vims, which virus binds to terminal sialic residues present on the cell surface of the cell to be infected by the virus.
US08802653B2 Deodorant compositions
A deodorant composition contains β-cyclodextrin, a fixative, a preservative, and a solvent.
US08802648B2 Repressor on IFN-λ promoter and siRNA against ZEB1 and BLIMP-1 to increase IFN-λ gene activity
The present invention is directed to the identification of a novel repressor located between ˜1.2 kb to ˜1.6 kb from the translation start site of the IFN-λ1 promoter. The present invention provides a method of using siRNAs against ZEB1 (binds to the repressor region) and BLIMP-1 (binds outside the repressor region) and increases the promoter activity of IFN-λ1 (i.e., increases the production of IFN-λ1 protein). siRNAs against ZEB1 mRNA or BLIMP-1 mRNA increase IFN-λ1 gene activity. There is provided a therapeutic application of siRNAs against ZEB1 and BLIMP-1 mRNAs in treating a mammal (including a human) by increasing the production of IFN-λ1 protein that promotes an anti-viral response as well as treats asthma diseases.
US08802641B2 Method for inhibiting onset of or treating pollen allergy
The intermolecular mutual recognition between a disease-state inducing substance (e.g., allergen group, pathogen et cetera) and a living body which functions at the time when such a disease-state inducing substance reaches the living body is inhibited by making use of pectins and nucleic acids.
US08802640B2 Oligonucleotides for RNA interference and biological applications thereof
The invention relates to compositions comprising double-stranded oligonucleotides of identical or different sequences and/or length, said oligonucleotides having sequences 3′N1N2 . . . Ni-1Ni . . . Nj5′ wherein—3′Ni . . . Nj5′ is half of a double-stranded 19-28mer oligonucleotide of sequence complementary to a target nucleic acid sequence present in a living cell, and—3′N1 . . . Ni-15′ is a 3-50mer overhang of sequence allowing oligomerization of said double-stranded oligonucleotide. Compositions of transfection comprising said oligonucleotide compositions and there used for therapeutical application.
US08802635B2 Antioxidant, anti-inflammatory, anti-radiation, metal chelating compounds and uses thereof
Potent compounds having combined antioxidant, anti-inflammatory, anti-radiation and metal chelating properties are described. Short peptides having these properties, and methods and uses of such short peptides in clinical and cosmetic applications are described.
US08802634B2 CD40-L Inhibitory Peptides
The present invention provides compositions comprising peptidyl inhibitors of CD40L-dependent signalling that are not derived from a natural binding partner of CD40L such as CD40, or from a native CD40-CD40L interface. More particularly, the peptidyl inhibitors of the present invention are derived from natural sources that do not express CD40-CD40L costimulatory pathways. The invention also provides synthetic derivatives and analogs of the peptidyl inhibitors having enhanced binding affinity for CD40L or enhanced inhibitory activity relative to their parent molecules.
US08802631B2 Peptides and methods for the treatment of gliomas and other cancers
The invention is based on the discovery that STM/Hop promotes proliferation of human glioblastoma-derived cells but not of normal astrocytes and that the proliferation requires the binding of STM/Hop to PrPc. The invention is directed to methods for treating cancer which rely on interfering with the Hop-PrPc interaction and to peptides, and antibodies raised against the peptides, which directly provide that interference. The invention is further based on the discovery that STI1230-245 peptide and its human homologue Hop23o-245 provide the desired interference with the STI1/Hop-PrPc interaction and inhibit the STI 1/Hop-induced proliferation of glioma and glioblastoma cells. The invention is thus further directed to methods of treating cancer that employ these peptides and functional derivatives thereof, and antibodies directed to the peptides and derivatives. The invention is further directed to means of treating cancer which involve reducing the effective amount of Hop or reducing the expression of Hop. The invention is further directed to means of alleviating or eliminating the side effects of drug therapy and radiotherapy used in treating patients with brain cancers.
US08802629B1 Corrective roles of insulin-like growth factor-binding protein-3 in cardiomyopathy
The invention relates to methods of promoting the expression of pro-angiogenic factors and decreasing the expression of anti-angiogenic and fibrotic factors in a cell, as well as the treatment of cardiomyopathy and wounds.
US08802616B2 Polymers for laundry detergents
A detergent composition having at least two components. The first component is from 8 to 50 wt % surfactants. The second component is from 0.05 to 4 wt % of a polymer which has polymerized residues of 40 to 80 wt % C1-C4 alkyl acrylates, 20 to 52 wt % C3-C6 carboxylic acid monomers, and 0 to 10 wt % of monomers having an alkyl group having at least ten carbon atoms.
US08802607B2 Liquid cleaning compositions containing long-chain fatty alcohols
A composition comprising a) a surfactant comprising an anionic surfactant; b) at least 8 weight % of the composition of a C12-18 fatty alcohol, and c) water. A cleansing method includes applying the composition to skin or hair and washing, and optionally rinsing with water.
US08802606B2 Lubricant composition having improved antiwear properties
The instant invention provides a lubricant composition having improved four-ball antiwear properties. The lubricant composition includes a base oil and one or more alkylethercarboxylic acid corrosion inhibitor(s) having the formula: wherein R is a straight or branched chain C6-C18 alkyl group and n is a number of from 0 to 5. The lubricant composition also includes an ashless antiwear additive including phosphorous. The four-ball antiwear properties are reported as an average diameter of wear scars pursuant to ASTM D4172. The average diameter of the wear scars resulting from the lubricant composition are at least 5% smaller than the average diameter of the wear scars resulting from a standard that includes the base oil and the antiwear additive and that is free of the one or more alkylethercarboxylic acid corrosion inhibitor(s).
US08802605B2 Lubricant composition
A lubricant composition includes a base oil and one or more alkylethercarboxylic acid corrosion inhibitor(s) having the formula; In this formula, R is a straight or branched chain C6-C18 alkyl group and n is a number of from 0 to 5. The lubricant composition can be utilized in a method for reducing corrosion of a steel article. The method includes the steps of providing the base oil and providing the one or more alkylethercarboxylic acid corrosion inhibitor(s). The method also includes the step of combining the base oil and the one or more alkylethercarboxylic acid corrosion inhibitor(s) to form the lubricant composition including less than about 0.1 weight percent of the one or more alkylethercarboxylic acid corrosion inhibitor(s). The method further includes the step of applying the lubricant composition to the steel article wherein the steel article passes corrosion testing according to ASTM D 665 B.
US08802601B2 Method of treating sandstone formations with reduced precipitation of silica
A method of treating a sandstone-containing formation penetrated by a wellbore is carried out by forming a treatment fluid comprising an aqueous fluid containing a hydrogen fluoride source and an amorphous silica precipitation inhibitor. The treatment fluid is introduced into the formation through the wellbore at a pressure below the fracture pressure of the formation to facilitate dissolution of formation materials, optionally as a single stage. The amorphous silica inhibitor may be a polycarboxylate and/or polycarboxylic acid, an organosilane or a phosphonate compound. The amorphous silica inhibitor may be capable of inhibiting precipitation of amorphous silica so that the treatment fluid contains at least about 500 ppm of silicon after at least about 100 minutes subsequent to the treatment fluid being introduced into the formation.
US08802594B2 Method for anti-sprouting and possibly fungicidal treatment of bulbs and/or tubers using clove oil and mint oil
The invention concerns a method for anti-sprouting and possible fungicidal treatment of bulbs and/or tubers comprising simultaneous, separate or time-staggered applications to the said bulbs and/or tubers of: eugenol and/or clove oil, and L-carvone and/or mint oil.
US08802593B2 Composition and method for controlling plant diseases
The present invention provides: a composition for controlling plant diseases comprising, as active ingredients, 4-oxo-4-[(2-phenylethyl)amino]-butyric acid and a quinone outside inhibitor; a method for controlling plant diseases which comprises applying effective amounts of 4-oxo-4-[(2-phenylethyl)amino]-butyric acid and a quinone outside inhibitor to a plant or soil for growing plant; and so on.
US08802591B2 Thermal direct printing dissolving paper
A label has a water dissolvable or water dispersible paper with a coating of a type which can be printed with direct thermal printing. The label is produced by passing a length of such paper with a freshly applied coating of the above type through an oven for drying before the coating has an opportunity to deteriorate the surface of the paper.
US08802588B2 Bismuth catalyst composition and process for manufacturing ethanol mixture
The present invention relates to a catalyst composition comprising at least one Group VIII metal and bismuth on a support, and to a process for manufacturing a product comprising ethanol and ethyl acetate from a feedstock comprising acetic acid over the catalyst composition under hydrogenation conditions, including a temperature of greater than about 290° C.
US08802586B2 Hydroprocessing catalysts and methods for making thereof
An improved hydroprocessing slurry catalyst is provided for the upgrade of heavy oil feedstock. The catalyst comprises dispersed particles in a hydrocarbon medium with the dispersed particles have an average particle size ranging from 1 to 300 μm. The catalyst has a total pore volume of at least 0.5 cc/g and a polymodal pore distribution with at least 80% of pore sizes in the range of 5 to 2,000 Angstroms in diameter. The catalyst is prepared from sulfiding and dispersing a metal precursor solution in a hydrocarbon diluent, the metal precursor comprising at least a Primary metal precursor and optionally a Promoter metal precursor, the metal precursor solution having a pH of at least 4 and a concentration of less than 10 wt. % of Primary metal in solution.
US08802581B2 Zircon compatible glasses for down draw
A glass that is down-drawable and ion exchangeable. The glass has a temperature T35kp at which the viscosity is 35 kilopoise. T35kp is less than the breakdown temperature Tbreakdown of zircon.
US08802580B2 Systems and methods for the crystallization of thin films
Crystallization of thin films using pulsed irradiation The method includes continuously irradiating a film having an x-axis and a y-axis, in a first scan in the x-direction of the film with a plurality of line beam laser pulses to form a first set of irradiated regions, translating the film a distance in the y-direction of the film, wherein the distance is less than the length of the line beam, and continuously irradiating the film in a second scan in the negative x-direction of the film with a sequence of line beam laser pulses to form a second set of irradiated regions, wherein each of the second set of irradiated regions overlaps with a portion of the first set of irradiated regions, and wherein each of the first and the second set of irradiated regions upon cooling forms one or more crystallized regions.
US08802578B2 Method for forming tin by PVD
A method for forming titanium nitride by PVD is disclosed, comprising: generating ions of a noble gas by glow discharge under a vacuum condition that a nitrogen gas and the noble gas are supplied; nitriding a surface of a wafer and a surface of a titanium target with the nitrogen gas; bombarding the surface of the titanium target with the ions of the noble gas after they are accelerated in an electric field so that titanium ions and titanium nitride are sputtered; and forming a titanium nitride layer by depositing titanium nitride on the surface of the wafer in a magnetic field, while titanium ions are injected into the surface of the wafer so that stress is introduced into the titanium nitride layer, wherein non-crystallization fraction of the titanium nitride layer and stress in the titanium nitride layer are increased by increasing kinetic energy of titanium ions which are injected into the surface of the wafer. In the method for forming titanium nitride by PVD according to the present disclosure, kinetic energy of titanium ions which are injected into the surface of the wafer is increased by controlling process parameters so that non-crystallization fraction of the titanium nitride layer and stress in the titanium nitride layer are increased.
US08802576B2 Semiconductor device and method of manufacturing the same
In one embodiment, a method of manufacturing a semiconductor device includes sequentially forming a first insulator, a second insulator, and a sacrificial layer on a semiconductor substrate, and forming plural core materials from the sacrificial layer and the second insulator. The method further includes forming first and second interconnects on side surfaces of each core material to form plural first interconnects and plural second interconnects alternately, each first interconnect having a first side surface in contact with a core material and a second side surface positioned on an opposite side of the first side surface, and each second interconnect having a third side surface in contact with a core material and a fourth side surface positioned on an opposite side of the third side surface. The method further includes removing the sacrificial layer so that the second insulator remains, after the first and second interconnects are formed.
US08802574B2 Methods of making jogged layout routings double patterning compliant
One illustrative method disclosed herein involves creating an overall target pattern that includes an odd-jogged feature with a crossover region that connects first and second line portions, wherein the crossover region has a first dimension in a first direction that is greater than a second dimension that is transverse to the first direction, decomposing the overall target pattern into a first sub-target pattern and a second sub-target pattern, wherein each of the sub-target patterns comprise a line portion and a first portion of the crossover region, and generating first and second sets of mask data corresponding to the first and second sub-target patterns, respectively.
US08802570B2 Pattern forming method
In a pattern forming method, a pattern having at least either a recess or a protrusion of a curable composition is formed of a curable composition by curing the curable composition into a cured film with a mold having a surface provided with at least either a recess or a protrusion, and separating the mold from the curable composition. The method includes (i) forming a gas generation region containing a gas generator agent so that the gas generation region will be disposed in contact with both the mold and the cured film between the mold and the cured film, (ii) generating a gas from the gas generation region, and (iii) separating the mold from the cured film during or after the step of (ii).
US08802568B2 Method for manufacturing chemical sensor with multiple sensor cells
In a method for manufacturing a chemical sensor with multiple sensor cells, a substrate is provided and an expansion inhibitor is applied to the substrate for preventing a sensitive material to be applied to an area on the substrate for building a sensitive film of a sensor cell to expand from said area. The sensitive material is provided and the sensitive film is built by contactless dispensing the sensitive material to said area.
US08802567B2 Plasma processing method
In a plasma torch unit, copper rods forming a coil as a whole are disposed inside copper rod inserting holes formed in a quartz block so that the quartz block is cooled by water flowing inside the copper rod inserting holes and cooling water pipes. A plasma ejection port is formed on the lowermost portion of the torch unit. While a gas is being supplied into a space inside an elongated chamber, high-frequency power is supplied to the copper rods to generate plasma in the space inside the elongated chamber so that the plasma is applied to a substrate.
US08802566B2 Method for producing semiconductor components on a substrate, and substrate comprising semiconductor components
A method for producing semiconductor components on a substrate including photolithographic patterning steps, in which method, on the substrate, a first layer to be patterned is applied and a second layer serving as a mask layer for the first layer to be patterned is applied, wherein a third layer serving as a mask for the second layer is applied, and wherein at least two photolithographic patterning processes are carried out successively for the second layer, wherein, during one of the patterning processes, after the production of a structure made from a photosensitive layer for the provision of a mask layer for a patterning process at the third layer, positive ramp angles α are produced at the patterning edges of the third layer, as a result of which the structures remaining free, given a thickness h of the third layer, decrease in size by a value D=2*h/tan α.
US08802565B2 Semiconductor plural gate lengths
Gate structures with different gate lengths and methods of manufacture are disclosed. The method includes forming a first gate structure with a first critical dimension, using a pattern of a mask. The method further includes forming a second gate structure with a second critical dimension, different than the first critical dimension of the first gate structure, using the pattern of the mask.
US08802557B2 Micro bump and method for forming the same
A method for forming a micro bump includes forming a first nano-particle layer on a substrate and forming a second nano-particle layer on the first nano-particle layer. The first and second nano-particle layers include a plurality of first nano particles and a plurality of second nano particles, respectively. The method further includes irradiating a laser beam onto the second nano-particle layer, where the laser beam penetrates through the second nano-particle layer and is at least partially absorbed by at least some of the first nano particles to generate heat. The first nano particles and the second nano particles have different absorption rates with respect to the laser beam.
US08802551B1 Methods of fabricating a semiconductor device using voids in a sacrificial layer
A semiconductor device is fabricated by forming first holes arranged along a first direction on an etch-target layer, forming dielectric patterns in the first holes, conformally forming a barrier layer on the dielectric patterns, forming a sacrificial layer on the barrier layer to define a first void, partially removing the sacrificial layer to expose the first void, anisotropically etching the barrier layer to form second holes below the first void, and etching portions of the etch-target layer located below the first and second holes to form contact holes. The first void may be formed on a first gap region confined by at least three of the dielectric patterns disposed adjacent to each other, and the sacrificial layer may include a material having a low conformality.
US08802542B2 Combination of a substrate and a wafer
The invention pertains to a combination of a substrate and a wafer, wherein the substrate and the wafer are arranged parallel to one another and bonded together with the aid of an adhesive layer situated between the substrate and the wafer, and wherein the adhesive is chosen such that its adhesive properties are neutralized or at least diminished when a predetermined temperature is exceeded. According to the invention, the adhesive layer is only applied annularly between the substrate and the wafer in the edge region of the wafer.
US08802541B2 Method for low temperature wafer bonding and bonded structure
A low temperature wafer bonding method and a bonded structure are provided. The method includes: providing a first substrate having a plurality of metal pads and a first dielectric layer close to the metal pads, where the metal pads and the first dielectric layer are on a top surface of the first substrate; providing a second substrate having a plurality of semiconductor pads and a second dielectric layer close to the semiconductor pads, where the semiconductor pads and the second dielectric layer are on a top surface of the second substrate; disposing at least one of the metal pads in direct contact with at least one of the semiconductor pads, and disposing the first dielectric layer in direct contact with the second dielectric layer; and bonding the metal pads with the semiconductor pads, and bonding the first dielectric layer with the second dielectric layer.
US08802535B2 Doped core trigate FET structure and method
Techniques for fabricating a field effect transistor (FET) device having a doped core and an undoped or counter-doped epitaxial shell are provided. In one aspect, a method of fabricating a FET device is provided. The method includes the following steps. A wafer is provided having a semiconductor material selected from the group consisting of silicon, silicon germanium and silicon carbon. At least one fin core is formed in the wafer. Ion implantation is used to dope the fin core. Corners of the fin core are reshaped to make the corners rounded or faceted. An epitaxial shell is grown surrounding the fin core, wherein the epitaxial shell includes a semiconductor material selected from the group consisting of silicon, silicon germanium and silicon carbon.
US08802533B1 Semiconductor device and method of manufacturing the same
A transistor device comprising epitaxial LDD and Halo regions and a method of manufacturing the same are disclosed. According to embodiments of the present disclosure, the method may comprise: forming a gate stack on a semiconductor substrate; forming a gate spacer which covers the top of the gate stack and sidewalls of the gate stack; forming source/drain grooves; epitaxially growing a Halo material layer in the source/drain grooves, wherein the Halo material layer has a first doping element therein; epitaxially growing source/drain regions which apply stress to a channel region of the device, wherein the source/drain regions have a second doping element, opposite in conductivity to the first doping element, therein; isotropically etching the source/drain regions to remove portions of the source/drain regions, wherein the etching also removes portions of the Halo material layer directly under the gate spacer and extends to the channel region to some extent, wherein remaining portions of the Halo material layer constitute Halo regions of the device; and epitaxially growing an LDD material layer to form LDD regions of the device.
US08802532B2 Bipolar transistor and method for manufacturing the same
Disclosed are example bipolar transistors capable of reducing the area of a collector, reducing the distance between a base and a collector, and/or reducing the number of ion implantation processes. A bipolar transistor may includes a trench formed by etching a portion of a semiconductor substrate. A first collector may be formed on the inner wall of the trench. A second collector may be formed inside the semiconductor substrate in the inner wall of the trench. A first isolation film may be formed on the sidewall of the first collector. An intrinsic base may be connected to the third collector. An extrinsic base may be formed on the intrinsic base and inside the first isolation film. A second isolation film may be formed on the inner wall of the extrinsic base. An emitter may be formed by burying a conductive material inside the second isolation film.
US08802531B2 Split-channel transistor and methods for forming the same
A Fin Field-Effect Transistor (FinFET) includes a fin, which includes a channel splitter having a first bandgap, and a channel including a first portion and a second portion on opposite sidewalls of the channel splitter. The channel has a second bandgap smaller than the first bandgap. A gate electrode includes a first portion and a second portion on opposite sides of the fin. A gate insulator includes a first portion between the first portion of the gate electrode and the first portion of the channel, and a second portion between the second portion of the gate electrode and the second portion of the channel.
US08802530B2 MOSFET with improved performance through induced net charge region in thick bottom insulator
A semiconductor power device includes a thick bottom insulator formed in a lower portion of a trench in a semiconductor epitaxial region. An electrically conductive gate electrode is formed in the trench above the bottom insulator. The gate electrode is electrically insulated from the epitaxial region by the bottom insulator and a gate insulator. Charge is deliberately induced in the thick bottom insulator proximate an interface between the bottom insulator and the epitaxial semiconductor region. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.
US08802525B2 Methods of forming charge storage structures including etching diffused regions to form recesses
Methods are disclosed that include selectively etching diffused regions to form recesses in semiconductor material, and forming charge storage structures in the recesses. Additional embodiments are disclosed.
US08802518B2 Semiconducor device and method for manufacturing the same
A semiconductor device and a method for manufacturing the same, the method comprising: providing a semiconductor substrate; forming a dummy gate area on the substrate, forming spacers on sidewalls of the gate area, and forming source and drain areas in the semiconductor substrate on both sides of the dummy gate area, the dummy gate area comprising an interface layer and a dummy gate electrode; forming a dielectric cap layer on the dummy gate area and source and drain areas; planarizing the device with the dielectric cap layer on the source and drain areas as a stop layer; further removing the dummy gate electrode to expose the interface layer; and forming replacement gate area on the interface layer. The thickness of the gate groove may be controlled by the thickness of the dielectric cap layer, and the replacement gates of desired thickness and width may be further formed upon requirements. Thus, the aspect ratio of the gate groove is reduced and a sufficient low gate resistance is ensured.
US08802515B2 Semiconductor device and method for manufacturing the same
A semiconductor device is manufactured using a transistor in which an oxide semiconductor is included in a channel region and variation in electric characteristics due to a short-channel effect is less likely to be caused. The semiconductor device includes an oxide semiconductor film having a pair of oxynitride semiconductor regions including nitrogen and an oxide semiconductor region sandwiched between the pair of oxynitride semiconductor regions, a gate insulating film, and a gate electrode provided over the oxide semiconductor region with the gate insulating film positioned therebetween. Here, the pair of oxynitride semiconductor regions serves as a source region and a drain region of the transistor, and the oxide semiconductor region serves as the channel region of the transistor.
US08802511B2 Display device
A display device for improving an aperture ratio of the pixel is provided. In the display device, a transparent oxide layer, an insulating film, and a conductive layer are sequentially stacked on a pixel region on a substrate, the conductive layer has a gate electrode of a thin film transistor connected to a gate signal line, and a region of the transparent oxide layer other than at least a channel region portion directly below the gate electrode is converted into an electrically conductive region, and a source signal line, a source region portion of the thin film transistor connected to the source signal line, a pixel electrode, and a drain region portion of the thin film transistor connected to the pixel electrode are formed from the conductive region.
US08802508B2 Semiconductor device package
Forming a packaged semiconductor device includes placing a semiconductor die attached to a carrier into a mold cavity having an injection port, wherein the semiconductor die has an encapsulant exclusion region on a top surface of the semiconductor die within an outer perimeter of the top surface; and flowing an encapsulant over the semiconductor die and carrier from the injection port, wherein the encapsulant flows around the encapsulant exclusion region to surround the encapsulant exclusion region without covering the encapsulant exclusion region. The encapsulant exclusion region has a first length corresponding to a single longest distance across the encapsulant exclusion region, wherein the first length is aligned, within 30 degrees, to a line defined by a shortest distance between an entry point of the injection port into the mold cavity and an outer perimeter of the encapsulant exclusion region.
US08802507B2 Fabrication method of semiconductor package device, and fabrication method of semiconductor package structure
A semiconductor package device, a semiconductor package structure, and fabrication methods thereof are provided, which mainly includes disposing a plurality of semiconductor chips on a wafer formed with TSVs (Through Silicon Vias) and electrically connecting the semiconductor chips to the TSVs; encapsulating the semiconductor chips with an encapsulant; and disposing a hard component on the encapsulant. The hard component ensures flatness of the wafer during a solder bump process and provides support to the wafer during a singulation process such that the wafer can firmly lie on a singulation carrier, thereby overcoming the drawbacks of the prior art, namely difficulty in mounting of solder bumps, and difficulty in cutting of the wafer.
US08802506B2 Method of manufacturing a semiconductor device and a semiconductor device produced thereby
A method of manufacturing a semiconductor device sealed in a cured silicone body by placing an unsealed semiconductor device into a mold and subjecting a curable silicone composition which is fed into the space between the mold and the unsealed semiconductor device to compression molding, the method being characterized by the fact that the aforementioned curable silicone composition comprises at least the following components: (A) an epoxy-containing silicone and (B) a curing agent for an epoxy resin; can reduce warping of the semiconductor chips and circuit board, and improve surface resistance to scratching.
US08802505B2 Semiconductor device and method of forming a protective layer on a backside of the wafer
A semiconductor device is made by forming solder bumps on a first side of a semiconductor wafer. A protective layer is formed on a second side of the semiconductor wafer opposite the first side. The protective layer can be adhesive paste, laminated film, spin-coated resin, epoxy based elastomer, organic rubbery material, polystyrene, polyethylene terephthalate, or other polymer material. The semiconductor wafer is singulated into semiconductor die. The semiconductor die is mounted to a carrier. A molding compound is formed around the semiconductor die. The protective layer provides stress relief for the semiconductor die. The protective layer is removed from the semiconductor die. The protective layer can provide a thermal dissipation, in which case it is made with metal or polymer-based material with a filler such as alumina, zinc oxide, silicon dioxide, silver, aluminum, and aluminum nitride.
US08802503B2 Processes for manufacturing an LED package with top and bottom electrodes
An LED package with an extended top electrode and an extended bottom electrode is formed from a first metal and a second metal. An LED is on an inner end of the first metal. An outer end of the first metal has been bent upward twice 90 degrees to form a top flat as an extended top electrode of the package. An outer end of the second metal has been bent downward twice 90 degrees to form a bottom flat as an extended bottom electrode of the package. The LED and a bonding wire may be encapsulated with glue.
US08802501B2 Integrated circuit packaging system with island terminals and method of manufacture thereof
A method of manufacture of an integrated circuit packaging system includes: providing a package paddle having an upper hole below a paddle top side, the upper hole bounded by an upper non-horizontal side with a curve surface; forming a terminal adjacent the package paddle; mounting an integrated circuit on the paddle top side; and forming an encapsulation within the upper hole.
US08802500B2 Integrated circuit packaging system with leads and method of manufacture thereof
A method of manufacture of an integrated circuit packaging system includes: providing a die paddle, having paddle projections along a paddle peripheral side; forming a lead terminal having a lead extension with the lead extension extending towards the paddle peripheral side and between the paddle projections; mounting an integrated circuit over the die paddle; connecting the integrated circuit and the lead extension; and forming an encapsulation over the die paddle and covering the integrated circuit and lead extension.
US08802499B2 Methods for temporary wafer molding for chip-on-wafer assembly
Methods for temporary wafer molding for chip-on-wafer assembly may include bonding one or more semiconductor die to an interposer wafer, applying a temporary mold material to encapsulate the bonded die, and backside processing the interposer, which may be singulated to generate assemblies comprising the bonded die, the interposer die, which may be bonded to packaging substrates. The temporary mold material may be removed and the bonded die may be tested. Additional die may be bonded to the assemblies based on the electrical testing. The interposer may be singulated utilizing one or more of: a laser cutting process, reactive ion etching, a sawing technique, and a plasma etching process. The backside processing may comprise thinning the interposer wafer to expose through-silicon-vias (TSVs) and placing metal contacts on the exposed TSVs. The die may be bonded to the interposer utilizing a mass reflow or thermal compression process.
US08802495B2 Semiconductor packages, methods of manufacturing the same, and semiconductor package structures including the same
A method of manufacturing a semiconductor package includes preparing a parent substrate including package board parts laterally spaced apart from each other, mounting a first chip including a through-via electrode on each of the package board parts, forming a first mold layer on the parent substrate having the first chips, planarizing the first mold layer to expose back sides of the first chips, etching the exposed back sides of the first chips to expose back sides of the through-via electrodes, forming a passivation layer on the planarized first mold layer, the etched back sides of the first chips, and the back sides of the through-via electrodes, and selectively removing the passivation layer to expose the back sides of the through-via electrodes.
US08802491B2 Electronic device and method of manufacturing semiconductor device
There is provided an electronic device including at least a first electrode, a second electrode disposed to be spaced apart from the first electrode, and an active layer disposed over the second electrode from above the first electrode and formed of an organic semiconductor material. A charge injection layer is formed between the first electrode and the active layer and between the second electrode and the active layer, and the charge injection layer is formed of an organic material having an increased electric conductivity when the charge injection layer is oxidized.
US08802490B2 Dielectric nanocomposites and methods of making the same
Techniques related to nanocomposite dielectric materials are generally described herein. These techniques may be embodied in apparatuses, systems, methods and/or processes for making and using such material. An example process may include: providing a film having a plurality of nanoparticles and an organic medium; comminuting the film to form a particulate; and applying the particulate to a substrate. The example process may also include providing a nanoparticle film having nanoparticles and voids located between the nanoparticles; contacting the film with a vapor containing an organic material; and curing the organic material to form the nanocomposite dielectric film. Various described techniques may provide nanocomposite dielectric materials with superior nanoparticle dispersion which may result in improved dielectric properties.
US08802487B2 Silk-screen stencil for printing onto a photovoltaic cell
Stencil for a screen-printing system, comprising slits (22, 23) in a central printing zone (13), forming a pattern to be printed, characterized in that it comprises one or more apertures (32) in a peripheral deforming zone (14), which apertures are intended to cause this peripheral deforming zone (14) to deform under the effect of a stress applied to the stencil while reducing deformation of the central printing one (13).
US08802485B2 Method for manufacturing a photovoltaic cell structure
In the frame of manufacturing a photovoltaic cell a layer (3) of silicon compound is deposited on a structure (1). The yet uncovered surface (3a) is treated in a predetermined oxygen (O2) containing atmosphere which additionally contains a dopant (D). Thereby, the silicon compound layer is oxidized and doped in a thin surface area (5).
US08802481B2 Photodetector capable of detecting the visible light spectrum
Apparatuses capable of and techniques for detecting the visible light spectrum are provided.
US08802477B2 Heterojunction III-V photovoltaic cell fabrication
A method for forming a heterojunction III-V photovoltaic (PV) cell includes performing layer transfer of a base layer from a wafer of a III-V substrate, the base layer being less than about 20 microns thick; forming an intrinsic layer on the base layer; forming an amorphous silicon layer on the intrinsic layer; and forming a transparent conducting oxide layer on the amorphous silicon layer. A heterojunction III-V photovoltaic (PV) cell includes a base layer comprising a III-V substrate, the base layer being less than about 20 microns thick; an intrinsic layer located on the base layer; an amorphous silicon layer located on the intrinsic layer; and a transparent conducting oxide layer located on the amorphous silicon layer.
US08802473B1 MEMS integrated pressure sensor devices having isotropic cavities and methods of forming same
A method embodiment includes providing a MEMS wafer comprising an oxide layer, a MEMS substrate, a polysilicon layer. A carrier wafer comprising a first cavity formed using isotropic etching is bonded to the MEMS, wherein the first cavity is aligned with an exposed first portion of the polysilicon layer. The MEMS substrate is patterned, and portions of the sacrificial oxide layer are removed to form a first and second MEMS structure. A cap wafer including a second cavity is bonded to the MEMS wafer, wherein the bonding creates a first sealed cavity including the second cavity aligned to the first MEMS structure, and wherein the second MEMS structure is disposed between a second portion of the polysilicon layer and the cap wafer. Portions of the carrier wafer are removed so that first cavity acts as a channel to ambient pressure for the first MEMS structure.
US08802466B2 Method for making light emitting diode
A method for making a light emitting diode is provided. In the method, a substrate having an epitaxial growth surface is provided. A buffer layer, a first semiconductor layer, an active layer, a second semiconductor layer are grown on the epitaxial growth surface in sequence. The first semiconductor layer, the active layer, and the second semiconductor layer constitute a source layer. A third optical symmetric layer, a metallic layer, a fourth optical symmetric layer, and a first optical symmetric layer are then disposed on a surface of the second semiconductor layer away from the substrate in the listed sequence. The substrate and the buffer layer are removed to expose the first semiconductor layer. A first electrode is applied on an exposed surface of the first semiconductor layer and a second electrode is applied to electrically connect with the second semiconductor layer.
US08802464B2 Method of forming process substrate using thin glass substrate and method of fabricating flat display device using the same
A method for fabricating a process substrate includes: providing a first substrate; providing a substrate and an auxiliary substrate; contacting the substrate and the auxiliary substrate with each other in a vacuum state, thereby forming micro spaces of a vacuum state between the substrate and the auxiliary substrate; and increasing a pressure at the outside of the contacted substrate and auxiliary substrate to attach the substrate and the auxiliary substrate to each other by a pressure difference between the micro spaces and the outside of the contacted substrate and auxiliary substrate.
US08802460B2 Method of mounting LED chip
A method of mounting an LED chip, which is intended to suppress void-generation inside an eutectic bonding without use of flux. This method includes a step of eutectically bonding a first metal layer (e.g., AuSn layer) on a rear surface of the LED chip, with a metal ground layer on a dielectric substrate (mounting member). This method includes a step of providing a second metal layer having the same metal component as the first metal layer, to the top surface of the metal ground layer on a dielectric substrate; and subsequently connecting the LED chip and the dielectric substrate by way of eutectically bond while the dielectric substrate is heated at its bottom surface remote from the metal ground layer to melt the second metal layer by heat source (heater or the like).
US08802459B2 Surface mount lateral light emitting apparatus and fabrication method thereof
A surface mount lateral light emitting apparatus, which includes a light emitting device; a first lead frame connected to the light emitting device; a second lead frame connected to the light emitting device; a first resin molding body in which a concave portion for mounting the light emitting device is formed and the first lead frame and the second lead frame are fixed; and a second resin molding body which covers the light emitting device to form a light emitting surface in the concave portion of the first resin molding body, wherein the first resin molding body contains a filler or a light diffusion agent; wherein in a periphery of the concave portion, a width of at least one side of the first resin molding body is not more than 0.2 mm; and wherein the first resin molding body and the second resin molding body are formed with a thermosetting resin.
US08802458B2 Laser diode and method of manufacturing the same
A laser diode capable of independently driving each ridge section, and inhibiting rotation of a polarization angle resulting from a stress applied to the ridge section without lowering reliability and a method of manufacturing the same are provided. A laser diode includes: three or more strip-like ridge sections in parallel with each other with a strip-like trench in between, including at least a lower cladding layer, an active layer, and an upper cladding layer in this order; an upper electrode on a top face of each ridge section, being electrically connected to the upper cladding layer; a wiring layer electrically connected to the upper electrode, in the air at least over the trench; and a pad electrode in a region different from regions of both the ridge section and the trench, being electrically connected to the upper electrode through the wiring layer.
US08802457B2 Backside surface treatment of semiconductor chips
A method includes performing a grinding to a backside of a semiconductor substrate, wherein a remaining portion of the semiconductor substrate has a back surface. A treatment is then performed on the back surface using a method selected from the group consisting essentially of a dry treatment and a plasma treatment. Process gases that are used in the treatment include oxygen (O2). The plasma treatment is performed without vertical bias in a direction perpendicular to the back surface.
US08802456B2 Betavoltaic battery with a shallow junction and a method for making same
This is a novel SiC betavoltaic device (as an example) which comprises one or more “ultra shallow” P+ N− SiC junctions and a pillared or planar device surface (as an example). Junctions are deemed “ultra shallow”, since the thin junction layer (which is proximal to the device's radioactive source) is only 300 nm to 5 nm thick (as an example). This is a betavoltaic device, made of ultra-shallow junctions, which allows such penetration of emitted lower energy electrons, thus, reducing or eliminating losses through electron-hole pair recombination at the surface.
US08802452B2 Magnetic tunnel junction device fabrication
In a particular embodiment, a method of forming a magnetic tunnel junction (MTJ) device includes forming an MTJ cap layer on an MTJ structure and forming a top electrode layer coupled to the MTJ cap layer. The top electrode layer includes at least two layers and one layer of the two layers includes a nitrified metal.
US08802450B2 Fluorescent methods and materials for directed biomarker signal amplification
Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.
US08802437B2 Meganuclease reagents of uses thereof for treating genetic diseases caused by frame shift/non sense mutations
The present invention relates to a method to treat a genetic disease in an individual caused by at least one frame shift or at least one non sense mutation in the human dystrophin gene comprising at least the step of bringing into contact at least one meganuclease enzyme, which recognizes and cuts a target site in the human dystrophin gene, with the genome of said individual under conditions wherein said at least one meganuclease recognizes and cleaves its target site in the human dystrophin gene. Said method applies also to a set of meganuclease enzymes, which each recognizes and cuts a different target site. The present invention also relates to a kit comprising, at least one meganuclease enzyme as defined above and medicament comprising said meganuclease.
US08802434B2 Biological cell culture, cell culture media and therapeutic use of biological cells
The protein NM23 is disclosed as an agent for the maintenance of undifferentiated biological cells in culture. The NM23 protein may act as a survival factor for such cultured cells, or to prevent the differentiation and maturation of the cultured cells. The use of NM23 protein is applicable to culture of stem and/or progenitor cells, and particularly to such cells cultured and adapted for therapeutic use. The invention provides methods, media and media supplements for use in the culture of biological cells, and further provides methods of preparing biological cells for therapeutic use, as well as methods of therapy utilising biological cells and medicaments comprising biological cells adapted for therapeutic use.
US08802432B2 Methods and cell cultures for promoting organogenesis and tissue development
Methods of promoting liver morphogenesis prior to the functioning of blood vessels by culturing liver cells with endothelial cells is provided. Also provided are cell cultures and method of promoting vasculogenesis of liver tissue by contacting liver cells with endothelial cells.
US08802431B2 Population of multipotent cardiac precursor cells derived from human blastocysts derived stem cells
A novel population of multipotent cardiac precursor (MCP) cells derived from human blastocysts derived stem cells is disclosed, methods for the preparation thereof and use of the cells for in vitro testing. Basement cells derived from hBS cells are also disclosed and method for the preparation of MCP cells from basement cells. The MCP cells have the following characteristics i) at least 1% of the cells exhibit no antigen expression of one or more markers for undifferentiated cell, the marker being selected from the group consisting of SSEA-3, SSEA-4, TRA-1-60, TRA-1-81 and Oct-4, ii) at least 1% of the cells exhibit no protein expression of one or more of a neural marker including nestin or GFAP iii) at least 1% of the cells exhibit protein and/or gene expression of one or more of a mesodermal marker including brachyury, vimentin or desmin iv) at least 1% of the cells exhibit protein and/or gene expression of Flk-1 (KDR). Furthermore, the MCP cells have a characteristic morphology. They grow as clusters of small, round and phase-bright cells; individual cells are 5-20 μm in diameter and each cluster is composed of 2-500 cells. They form clusters of round or elongated shape, that appear as loosely adherent cell clumps that as illustrated in FIG. 2 panel a, b and c. Furthermore, they have a relatively high nucleus-to-cytoplasma ratio, e.g. 1:2-1:64 of the total volume of the cell and/or appear as balloons on a string, as illustrated in FIG. 18, schematic sketch. Moreover, the MCP cells are non-contracting.
US08802421B2 Method of propagating and delivering yeast
A method of propagating, concentrating and delivering yeast is disclosed. The method comprises the steps of producing and inoculating a bag, propagating yeast within the bag, and concentrating the yeast in a section of the bag that is the removed from the remainder of the bag while not exposing any portion of the yeast therein to an external environment. In order to remove the bag, which contains the most concentrated slurry of yeast, a smaller bag is heat-sealed off of the larger bag, thereby creating a separate bag for the living sediment, which is still the bag in which the sediment was propagated. In a preferred embodiment, the method is specific to the alcoholic beverage industry. The method is also applicable to other industries that grow and transport yeast, bacteria, molds and other microorganisms.
US08802418B2 Protein and nucleic acid delivery vehicles, components and mechanisms thereof
Complex viruses are assembled from simple protein subunits by sequential and irreversible assembly. During genome packaging in bacteriophages, a powerful molecular motor assembles at the special portal vertex of an empty prohead to initiate packaging. An aspect of the invention relates to the phage T4 packaging machine being highly promiscuous, translocating DNA into finished phage heads as well as into proheads. Single motors can force exogenous DNA into phage heads at the same rate as into proheads and phage heads undergo repeated initiations, packaging multiple DNA molecules into the same head. This shows that the phage DNA packaging machine has unusual conformational plasticity, powering DNA into an apparently passive capsid receptacle, including the highly stable virus shell, until it is full. These features allow for the design of a novel class of nanocapsid delivery vehicles.
US08802416B2 Thermostable organic solvent tolerant protease from gram-positive bacteria
The present invention relates to a thermostable protease useful as an enzyme for industrial use, a gene encoding the same and a method of producing the enzyme by genetic engineering technique. More particularly, the present invention discloses a thermostable organic solvent tolerant protease and its code gene and application. The invention also discloses a method for preparing protease by isolating from Bacillus subtilis isolate Rand bacteria. The activity and stability of protease (preferably named Rand protease) at high temperature, and can be used in fields of washing agent industry, foodstuff industry, biological pharmacy and environmental biological technique.
US08802415B2 Talaromyces transformants
The invention relates to a Talaromyces transformant comprising one or more recombinant gene, capable of producing cellulase in the absence of cellulase inducer in a glucose medium, having a cellulase activity of 2 WSU/ml or more, in 16 times or more diluted supernatant or broth.
US08802411B2 ADP detection based luminescent phosphotransferase or ATP hydrolase assay
The invention provides compositions and methods to determine or detect the activity of enzymes, including phosphotransferases such as kinases (e.g., protein, lipid, and sugar kinases) and ATP hydrolases such as ATPases, e.g., HSP90, that employ ATP as a substrate and form ADP as a product by monitoring changes in ADP. Methods, kits and compositions for monitoring changes in metabolites such as ADP are disclosed.
US08802410B2 Mass-sensitive chemical sensor having a binding surface for ligands
There is disclosed an analytical method and a sensor suitable for carrying out the method. More specifically, there is disclosed a method for preparing a mass sensitive chemical sensor capable of detecting binding analyte species to a surface comprising cells.
US08802406B2 Process for the production of ethanol and butanol
The present invention relates to a process for the production of ethanol and butanol from biomass, and in particular to a process for the production of ethanol and butanol using two separate fermentation step subjecting the biomass feedstock to anaerobic fermentation at a pH below 6.0 and at a temperature in the range 20 to 700° C. and so as to convert the biomass to a product predominantly comprising acetic acid and butyric acid with at least a 2:1 ratio by weight of acetic acid to butyric acid, c) treating the product of stream of step (b) to separate a solution comprising the acetic acid and butyric acid by: (i) separating a solution comprising the acetic acid and butyric acid from any residual solids and (ii) separating bacteria and/or pasteurizing or sterilizing the solution from the first fermentation step, and d) in a second fermentation step fermenting the solution comprising the acetic acid and butyric acid from the step (c) to form ethanol and butanol.
US08802401B2 Methods and compositions for preparation of selectively protected carbohydrates
The disclosure relates to engineered P450 polypeptides and use of such polypeptides in chemoenzymatic methods to construct selectively protected carbohydrates, which are useful as building blocks for preparation of carbohydrate derivatives and oligosaccharides
US08802394B2 Method of expressing proteins with disulfide bridges with enhanced yields and activity
Provided herein are methods for expressing proteins with disulfide bridges such as Vicrostatin (VCN), a chimeric variant of native snake venom disintegrin Contortrostatin (CN). The methods include what is believed to be a more efficient natural selection process that results in generating increased amounts of correctly-folded active conformers of proteins with disulfide bridges. In an aspect, this is achieved by growing Origami B cells in a more optimal redox environment during the induction of heterologous recombinant protein production.
US08802384B2 Method or system using biomarkers for the monitoring of a treatment
The present invention relates to biomarkers to monitor the activity of the compound 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone or a pharmaceutically acceptable salt thereof, and especially its monoethanesulphonate salt form, when used alone or optionally in combination with further pharmaceutically active ingredients and/or further treatments, such as for example radiotherapy.
US08802383B2 Monoclonal antibodies and uses thereof
The technology relates to monoclonal antibodies useful in the identification of cancer cells. In one embodiment, mAbs with specificity for tumor antigens are provided. In one embodiment, methods for treating cancer using mAbs are provided. In another embodiment, methods for detecting cancerous cells are provided. In another embodiment, kits for detecting cancerous cells are provided.
US08802381B2 Methods for predicting pregnancy outcome in a subject by HCG assay
The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
US08802380B2 Method for testing or screening protein synthesis inhibitors
This invention provides methods for screening an inhibitor of protein synthesis by measuring the level of relocalization of an SMN complex component from the cytoplasm to the nucleus. Additionally, the invention provides a kit and a system for screening protein synthesis inhibitors in a cell.
US08802378B2 Potency test for vaccine formulations
The invention relates to certain methods for the determination of an antigen content of a first antigen in a mixture comprising two or more antigens. The invention also relates to a potency test for an antigen in a combination vaccine. The method allows the determination of the antigen content in a mixture additionally comprising antibodies that are capable of binding with the antigen.
US08802376B2 Methods for identifying candidate cytotoxic antibody molecules
The disclosure relates to methods for screening candidate antibody molecules which bind to podocalyxin-like protein (PODXL) and/or to undifferentiated pluripotent stem cells and particularly, although not exclusively, to methods for identifying candidate cytotoxic antibody molecules.
US08802375B2 Methods for characterizing antibody binding affinity and epitope diversity in food allergy
Methods for performing epitope mapping, and for characterizing the antibody binding affinity and epitope diversity of antibodies in a sample using peptide microarray are provided. In some aspects, methods are provided for the specific characterization of IgE and IgG4. Also disclosed are methods for diagnosing whether a milk-allergic individual will outgrow his or her allergy based on the characterization of the individual's milk allergen-specific IgE antibodies.
US08802374B2 Truncated epiderimal growth factor receptor (EGFRt) for transduced T cell selection
A non-immunogenic selection epitope may be generated by removing certain amino acid sequences of the protein. For example, a gene encoding a truncated human epidermal growth factor receptor polypeptide (EGFRt) that lacks the membrane distal EGF-binding domain and the cytoplasmic signaling tail, but retains an extracellular epitope recognized by an anti-EGFR antibody is provided. Cells may be genetically modified to express EGFRt and then purified without the immunoactivity that would accompany the use of full-length EGFR immunoactivity. Through flow cytometric analysis, EGFRt was successfully utilized as an in vivo tracking marker for genetically modified human T cell engraftment in mice. Furthermore, EGFRt was demonstrated to have cellular depletion potential through cetuximab mediated antibody dependent cellular cytotoxicity (ADCC) pathways. Thus, EGFRt may be used as a non-immunogenic selection tool, tracking marker, a depletion tool or a suicide gene for genetically modified cells having therapeutic potential.
US08802368B2 Single molecule sequencing of captured nucleic acids
The invention provides methods and devices for detecting, enumerating or identifying target nucleic acid molecules using immobilized capture probes and single molecule sequencing techniques.
US08802362B2 Methods and devices for separating liquid components
Methods and devices for preparing a solid-fibrin web are provided. One method may include drawing blood from a patient, separating plasma from the blood, contacting the plasma with a calcium-coagulation activator and concurrently coagulating and axially centrifuging the plasma to form the solid-fibrin web. The solid-fibrin web may be suitable for regenerating body tissue in a living organism. Devices used in the methods may also be provided.
US08802361B2 Composition and method for the restoration and preservation of transplant organs procured from DCD donors
The present invention provides a perfusion solution comprising specific metabolic agents, antioxidant agents, and membrane stabilizer agents that can help improve preservation, organ viability, and in some cases recover organs that would otherwise being unusable for transplantation. In a further embodiment, the perfusion solution can be used in combination with hypothermic machine perfusion. It has been found that combination of the perfusion solution and hypothermic machine perfusion can help prevent or reduce further damage to the organ and restore the organ's anti-oxidant system, stabilize the cellular cytoskeleton and cellular membranes, inhibit arachidonic acid pathway, provide oncotic support, reduce interstitial edema formation, and help restore energy stores within the organ. As a result, the method can be used to improve the viability of otherwise marginal donor organs.
US08802360B2 Reticles for use in forming implant masking layers and methods of forming implant masking layers
In one example, a reticle disclosed herein includes a body having a center, an arrangement of a plurality of exposure patterns, wherein a center of the arrangement is offset from the center of the body, and at least one open feature defined on or through the body of the reticle. In another example, a method is disclosed that includes forming a layer of photoresist above a plurality of functional die and a plurality of incomplete die, exposing the photoresist material positioned above at least one of the functional die and/or at least one of the incomplete die, performing an incomplete die exposure processes via an open feature of the reticle to expose substantially all of the photoresist material positioned above the plurality of incomplete die, and developing the photoresist to remove the portions of the photoresist material positioned above the incomplete die.
US08802358B2 Method of forming alignment film
A method of forming an alignment film is provided. A photosensitive polymer material is provided, wherein the photosensitive polymer material defines a first pixel area and a second pixel area respectively defining a first sub-pixel area and the second sub-pixel area. In a first exposure, the photosensitive polymer material is irradiate by a first exposure light and a second exposure light to form a first alignment portion and a second alignment portion with different alignment directions in the first sub-pixel of the first pixel area and the second sub-pixel of the second pixel area respectively. In a second exposure, the photosensitive polymer material is irradiated with the first exposure light and the second exposure light to form a third alignment portion and a fourth alignment portion with different alignment directions in the first sub-pixel of the second pixel area and the second sub-pixel of the first pixel area respectively.
US08802354B2 Water mark defect prevention for immersion lithography
A photoresist material having a polymer that turns soluble to a base solution in response to reaction with acid. The material includes a photo-acid generator (PAG) that decomposes to form acid in response to radiation energy and a quencher capable of neutralizing acid and having a reduced mobility. The photoresist material can thereby prevent water mark defects from immersion lithography.
US08802353B2 Compound for resist and radiation-sensitive composition specification
A radiation-sensitive composition containing 1 to 80% by weight of a solid component and 20 to 99% by weight of a solvent. The solid component contains a compound B which has (a) a structure derived from a polyphenol compound A by introducing an acid-dissociating group to at least one phenolic hydroxyl group of the polyphenol compound A which is synthesized by a condensation between a di- to tetrafunctional aromatic ketone or aromatic aldehyde each having 5 to 36 carbon atoms with a compound having 1 to 3 phenolic hydroxyl groups and 6 to 15 carbon atoms, and (b) a molecular weight of 400 to 2000. The composition containing the compound B is useful as an acid-amplified, non-polymeric resist material, because it is highly sensitive to radiation such as KrF excimer lasers, extreme ultraviolet rays, electron beams, and X-rays, and provides resist patterns with a high resolution, high heat resistance, and high etching resistance.
US08802352B2 Salt, photoresist composition and method for producing photoresist pattern
A salt represented by formula (I): wherein Q1, Q2, L1, W, and Z+are defined in the specification.
US08802350B2 Photoresist composition, resist-pattern forming method, polymer, and compound
A photoresist composition includes a polymer that includes a structural unit shown by the following formula (1), and a photoacid generator. R1 in the formula (1) represents a hydrogen atom, a fluorine atom, a methyl group, or a trifluoromethyl group, Z represents a group that forms a divalent alicyclic group having 3 to 20 carbon atoms together with a carbon atom bonded to X, X represents an alkanediyl group having 1 to 6 carbon atoms, Y represents a hydrogen atom or —CR2R3(OR4), and R2 to R4 independently represent a hydrogen atom or a monovalent hydrocarbon group, provided that R3 and R4 optionally bond to each other to form a cyclic ether structure together with a carbon atom bonded to R3 and an oxygen atom bonded to R4.
US08802349B2 Actinic ray-sensitive or radiation-sensitive resin composition and resist film and pattern forming method using the composition
Provided is an actinic ray-sensitive or radiation-sensitive resin composition including: (A) a resin capable of increasing the solubility in an alkali developer by the action of an acid, the resin containing (a) a repeating unit represented by the following formula (AN-01), (B) a compound capable of generating an acid upon irradiation with an actinic ray or radiation, and (C) a resin that contains at least either a fluorine atom or a silicon atom and contains a repeating unit having a group capable of decomposing by the action of an alkali developer to increase the solubility in an alkali developer: wherein the variables in formula (AN-01) are defined in the description.
US08802348B2 Radiation-sensitive resin composition
A radiation-sensitive resin composition includes (A) an acid labile group-containing resin which becomes alkali-soluble by an action of an acid, (B) a radiation-sensitive acid generator, and (C) a solvent. The resin (A) includes repeating units shown by formulas (1) and (2), wherein R1 and R2 represent a hydrogen atom or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, R3 represents a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, X represents a hydrogen atom, a hydroxyl group, or an acyl group, m represents an integer from 1 to 18, and n represents an integer from 4 to 8.
US08802346B2 Metal compositions and methods of making same
The present invention relates to a process for forming metal-containing films by applying a photosensitive metal-containing composition on a substrate, drying the photosensitive metal-containing composition, exposing the photosensitive metal-containing composition to a source of actinic radiation and applying a post-treatment to the metal-containing composition. The process also includes exposing the photosensitive metal-containing composition to a source of actinic radiation through a mask or mold and developing the unexposed portion of the composition. Another embodiment of the invention is a metal-containing film, three-dimensional object or article formed by the process. The invention is useful in producing a directly patterned metal-containing film and a microdevice.
US08802344B2 Toner processes utilizing washing aid
A process for making toner particles is provided. In embodiments, a suitable process includes adding a washing aid agent to toner particles at the time of washing the toner particles prior to their drying and recover. The washing aid agent assist in the removal of ionic species, including surfactants and ions that are part of the emulsion aggregation process, from the resulting toner particles. Utilization of the washing aid agent produces toner particles having improved charging characteristics.
US08802342B2 Crystalline resins for toners
The present invention relates to a crystalline resin for toners which includes a composite resin including a polycondensation-based resin component obtained by polycondensing an alcohol component containing an aliphatic diol having 2 to 10 carbon atoms with a carboxylic acid component containing an aromatic dicarboxylic acid, and a styrene-based resin component; a resin binder containing the crystalline resin and a non-crystalline resin; and a toner for electrophotography which contains the resin binder. According to the present invention, there are provided a crystalline resin for toners which is capable of producing a toner that is excellent in not only low-temperature fixing ability but also gloss of images and anti-filming property, a resin binder, and a toner for electrophotography.
US08802337B2 Electrophotographic photoreceptor, image forming apparatus, and process cartridge
An electrophotographic photoreceptor includes a support; an undercoat layer which is provided on the support and contains at least a binder resin, metal oxide particles, and an electron-accepting compound having an anthraquinone structure, in which a content of the electron-accepting compound is from 0.5% by weight to 1.5% by weight with respect to the metal oxide particles and a contact angle of the metal oxide particles with respect to water is from 7° to 12°; and a photosensitive layer which is provided on the undercoat layer.
US08802336B2 Intermediate transfer member comprising an inorganic layer, and image forming method and image forming apparatus employing thereof
An image forming apparatus may include an electrophotographic photoreceptor and an intermediate transfer member. An image may be formed by primary transferring a toner image held on a surface of an electrophotographic photoreceptor to an intermediate transfer member, and secondary transferring the toner image from the intermediate transfer member to a transferee material. A dispersive component of surface energy of the electrophotographic photoreceptor and a dispersive component of surface energy of the intermediate transfer member may satisfy a relationship of (the dispersive component of surface energy of the electrophotographic photoreceptor)≦(the dispersive component of surface energy of the intermediate transfer member).
US08802335B2 Extreme ultra violet (EUV) mask
An extreme ultra violet (EUV) mask is disclosed, which prevents defects from shot overlap encountered in wafer exposure as well as reflection of unnecessary EUV and DUV generated in a black border region, such that a pattern CD is reduced and defects are not created. The EUV mask includes a quartz substrate, a multi-layered reflection film formed over the quartz substrate to reflect exposure light, an absorption layer formed over the multi-layered reflection film, a black border region formed over the quartz substrate that does not include the multi-layered reflection film, and a blind layer formed in a position including at least one of over the absorption layer, over the quartz substrate, and below the quartz substrate.
US08802327B2 Electrode structure capable of separate delivering gas and fluid and passive fuel cell using the same
The present invention discloses an electrode structure capable of separately delivering gas and fluid which is applied to a passive fuel cell. The electrode structure includes an electrode portion and a water removal plate, and the electrode portion is adjacent to the water removal plate. The water removal plate includes a first surface, a second surface opposite to the first surface, a plurality of gas passages passing from the first surface to the second surface, and a plurality of liquid passages disposed on the first surface. The surfaces of the gas passages are treated with hydrophobic treatment, and the surfaces of the liquid passages are treated with hydrophilic treatment.
US08802326B2 Fuel cell separator plate
A fuel cell stack and a bipolar plate assembly is provided that may include straight-through tunnels to transport fluids from one side of a header seal to an opposite side of a header seal, fluidly connecting fuel cell stack reactant headers and bipolar plate reactant flow channels.
US08802323B2 Method for the production of electrical energy from ammonium
The invention provides a method for the production of electrical energy from an ammonium (NH4+) containing aqueous liquid comprising (a) separating at least part of the ammonium as ammonium salt or concentrated ammonium salt comprising solution from the ammonium containing aqueous liquid, (b) decomposing at least part of the ammonium salt or salt solution into an ammonia (NH3) comprising gas and one or more other decomposition products, and (c) feeding at least part of the ammonia comprising gas to an fuel cell.
US08802321B2 Horizontally graded structures for electrochemical and electronic devices
The present invention provides a graded multilayer structure, comprising a support layer (1) and at least 10 layers (2, 3) forming a graded layer, wherein each of the at least 10 layers (2, 3) is at least partially in contact with the support layer (1), wherein the at least 10 layers (2, 3) differ from each other in at least one property selected from layer composition, porosity and conductivity, and wherein the at least 10 layers (2, 3) are arranged such that the layer composition, porosity and/or conductivity horizontally to the support layer (1) forms a gradient over the total layer area.
US08802319B2 Block copolymer electrolyte composite membranes and methods of producing the same
The present invention relates to block copolymer electrolyte composite membranes with improved ionic conductivity. The block copolymer electrolyte composite membrane in accordance with an aspect of the present invention can comprise a plate-like inorganic filler as surface-modified with a sulfonic group; and a block copolymer comprising at least one selected from the group consisting of a sulfonic group, a carbonic acid group, and a phosphoric acid group.
US08802318B2 Compound and composition including compound, with fuel cell, fuel cell electrode and fuel cell electrolyte membrane using same
A compound that is a polymerization product of a compound composition that contains a diisocyanate-based compound and an aromatic polyol, a composition that contains the compound and an interpenetration polymer, a fuel cell electrode including either the compound or the composition, a fuel cell electrolyte membrane including either the compound or the composition, and a fuel cell including at least one selected from the group consisting of the fuel cell electrode and the fuel cell electrolyte membrane.
US08802317B2 Oxidation-stabilised polymer electrolyte membrane for fuel cells
Polymer electrolyte membrane (PEM) made from perfluorosulfonic acid polymers, displaying proton conductivity at least in the presence of water, adequate for operation in a fuel cell, comprising at least one oxidation protection agent and additives. The PEM is an acid/base polymer blend which forms acidic and basic domains, the basic polymer being formed by polybenzimidazole (PBI) and the at least one oxidation protection agent being formed by manganese oxide.
US08802315B2 Composition, composite prepared from the composition, electrode using the composition or the composite, composite membrane including the composite, and fuel cell including the composite membrane
A composition including a cross-linkable compound and at least one selected from compounds represented by Formula 1, a composite obtained from the composition, an electrode including the composition or the composite, a composite membrane including the composite, and a fuel cell including the composite membrane, wherein, in Formula 1, a and R are as defined in the specification.
US08802312B2 Fuel cell separators capable of suppressing variation in pressure loss
A fuel cell according to the present invention includes a power generation unit. The power generation unit is formed by stacking a first metal separator, a first membrane electrode assembly, a second metal separator, a second membrane electrode assembly, and a third metal separator. The number of flow grooves in a first oxygen-containing gas flow field is different from the number of flow grooves in a second oxygen-containing gas flow field. The first oxygen-containing gas flow field and the second oxygen-containing gas flow field have the same length, and the flow grooves in the first oxygen-containing gas flow field and the flow grooves in the second oxygen-containing gas flow field have the same depth.
US08802310B2 Fuel cell system
When a request power for a fuel cell is smaller than a predetermined value, a fuel cell system stops the supply of an oxidizing gas to the fuel cell and lowers the output voltage of the fuel cell from a use upper limit voltage to a reduction voltage to perform catalyst activation processing. When the output voltage of the fuel cell lowers to an air blow voltage because of the shortage of the oxidizing gas, the fuel cell system resupplies the oxidizing gas to recover the output voltage of the fuel cell.
US08802306B2 Fuel cell system and stack thereof
A fuel cell system having improved driving performance is disclosed. The fuel cell system includes a stack, which may include a membrane electrode assembly, a separator and end plates provided on the both sides of the stacked membrane electrode assembly and the separator. The membrane electrode assembly may include an anode electrode, a cathode electrode, and an electrolyte membrane. The separator may be positioned with respect to the anode electrode and the cathode electrode, respectively. The end plate may include an oxidant inlet configured to supply oxidant to the cathode electrode, an unreacted oxidant outlet configured to output the unreacted oxidant from the cathode electrode, and a absorption member in fluid communication between the oxidant inlet and the unreacted oxidant outlet.
US08802304B2 Bifunctional (rechargeable) air electrodes comprising a corrosion-resistant outer layer and conductive inner layer
Performance, properties and stability of bifunctional air electrodes may be improved by using modified current collectors, and improving water wettability of air electrode structures. This invention provides information on creating non-corroding, electrically rechargeable, bifunctional air electrodes. In some embodiments, this bifunctional air electrode includes a corrosion-resistant outer layer and an electrically conductive inner layer. In some embodiments, this bifunctional air electrode includes titanium suboxides formed by reducing titanium dioxide. Titanium suboxides may be corrosion-resistant and electrically conductive.
US08802302B2 Air battery including oxygen-containing solvent
An air battery which can maintain a good performance and inhibit ingress of water into its housing. The air battery including a power section having an air electrode, an anode containing an alkali metal, and an electrolyte layer conducting ions between the air electrode and the anode; an oxygen-containing solvent showing both hydrophobic nature and oxygen solubility; a housing being configured to incorporate the power section and the oxygen-containing solvent; and an oxygen supply portion being configured to supply oxygen gas to the oxygen-containing solvent. The oxygen-containing solvent being arranged between the oxygen supply portion and the electrolyte layer.
US08802300B2 Rechargeable lithium battery
A rechargeable lithium battery including a positive electrode including a positive active material, a negative electrode including a negative active material, and a non-aqueous electrolyte including a non-aqueous organic solvent and a lithium salt. The positive electrode has an active-mass density of about 3.7 to 4.1 g/cc, and the non-aqueous electrolyte includes a nitrile-based compound additive, a non-aqueous organic solvent, and a lithium salt.
US08802298B2 Non-aqueous electrolyte secondary cell
A non-aqueous electrolyte secondary cell having high temperature storage characteristics and cycle characteristics is provided.This object is realized by adopting the following configuration.The non-aqueous electrolyte secondary cell includes a positive electrode having a positive electrode active material; a negative electrode having a negative electrode active material; and a non-aqueous electrolyte having a non-aqueous solvent and an electrolyte salt. And the positive electrode active material contains a compound represented by Lia(NibCocMnd)1−x−yWxZryO2 (0.9≦a≦1.2, 0.3≦b≦0.6, 0.1≦c≦0.7, 0≦d≦0.4, b+c+d=1, 0.001≦x≦0.05, 0.001≦y≦0.05); and the non-aqueous electrolyte contains at least one compound selected from the group consisting of cyclohexylbenzene, tert-butylbenzene and tert-amylbenzene in a total concentration of 0.1 to 5% by mass relative to the mass of the non-aqueous electrolyte.
US08802297B2 Graphite particles and lithium secondary battery using the same as negative electrode
A method for forming a negative electrode for a lithium secondary battery, includes providing a paste comprising graphite particulates comprise assembled or bound graphite particles in each of which a plurality of flat-shaped particles are assembled or bound together so that the planes of orientation are not parallel to one another, and the mixture including 3 to 10 parts by weight of the organic binder per 100 parts by weight of the graphite particulates, a binder and a solvent, coating the paste on a current collector, drying the paste coated on the current collector to form a mixture of the graphite particulates and the binder, and integrating the mixture with the current collector by pressing to provide a density of the mixture of graphite particulates and organic binder of 1.5 to 1.9 g/cm3.
US08802292B2 Hydrogen-absorbing alloy for alkaline storage battery and method for manufacturing the same
A hydrogen-absorbing alloy for an alkaline storage battery with high power characteristics and excellent output power stability and a method for manufacturing the same are provided. The hydrogen-absorbing alloy for an alkaline storage battery of the invention is represented by ABn (A: LaxReyMg1-x-y, B: Nin-zTz, Re: at least one element selected from rare earth elements including Y (other than La), T: at least one element selected from Co, Mn, Zn, and Al, and z>0) and has a stoichiometric ratio n of 3.5 to 3.8, a ratio of La to Re (x/y) of 3.5 or less, at least an A5B19 type structure, and an average C axis length α of crystal lattice of 30 to 41 Å.
US08802291B2 Cathode composite material and lithium ion battery using the same
A cathode composite material includes a cathode active material and a coating layer coated on a surface of the cathode active material. The cathode active material includes a layered type lithium nickel cobalt manganese oxide. The coating layer comprises a lithium metal oxide having a crystal structure belonging to C2/c space group of the monoclinic crystal system. The present disclosure also relates to a lithium ion battery including the cathode composite material.
US08802286B2 Negative electrode for use with secondary battery and secondary battery using such negative electrode
A negative electrode for a secondary battery includes a negative electrode current collector and a negative electrode active material layer provided in the negative electrode current collector and which is alloyed with the negative electrode current collector at least at a part of an boundary face between it and the negative electrode current collector, wherein the negative electrode current collector has a first surface on which the negative electrode active material layer is formed and a second surface on which the negative electrode active material layer is not formed, the negative electrode having a portion in which the second surfaces of the negative electrode current collector are opposed to each other.
US08802284B2 Battery pack
A battery pack that includes a case and a bare cell. The battery pack further includes a screw for combining the case and the bare cell to each other. The screw includes: a head portion having a screw groove formed in a first surface thereof; a body portion disposed on a second surface of the head portion and including a screw thread; and a connection portion disposed between the head portion and the body portion, wherein a thickness of the head portion is within 0.3 to 1 mm.
US08802283B2 Fabricating method of secondary battery
A fabrication method of a secondary battery having excellent electrolyte impregnating characteristics and excellent productivity without fracture of an electrode plate or separation of an active material is disclosed. The fabrication method includes providing a plurality of first electrode plates and second electrode plates and two separators, attaching the plurality of first electrode plates to portions between the two separators, attaching the plurality of second electrode plates to one of the two separators, winding the separators having the plurality of first and second electrode plates to form a wound electrode assembly, removing curved portions of the outermost separators positioned at exterior sides of the first and second electrode plates to form a stacked electrode assembly and accommodating the stacked electrode assembly in a sheath member.
US08802282B2 Battery parts having retaining and sealing features and associated methods of manufacture and use
Battery parts having retaining and sealing features and associated assemblies and methods are disclosed herein. In one embodiment, a battery part includes a base portion that is configured to be embedded in battery container material of a corresponding battery container. The battery part and base portion include several torque resisting features and gripping features that resist torsional or twist loads that are applied to the battery part after it has been joined to the battery container. For example, the base portion can include several internal and external torque resisting features and gripping features that are configured to resist twisting or loosening of the battery part with reference to the battery container material, as well as prevent or inhibit fluid leakage from the battery container.
US08802280B2 Battery device and electronic apparatus
A battery charger includes a battery attachment section configured to have a rechargeable battery releasably attached thereto. The battery attachment section includes a flat attachment surface having a width corresponding to a width of a bottom surface of a case of the battery to be charged and a length greater than a length of the bottom surface of the case of the battery to be charged; a plurality of locking hooks provided on the attachment surface; a charger terminal configured to contact a terminal of the battery to be charged, the charger terminal including a plurality of plate-shaped contact pieces configured to be inserted into engaging grooves of the battery to be charged; and an attachment projection adjacent to the attachment surface and configured to secure the battery to the charger.
US08802277B2 Electrode structure and battery device manufacturing method
An electrode is provided with a metal terminal extending from a battery module main body, a bolt which has an expanded section configuring a retaining section at a rear end portion and penetrates the metal terminal upward, and an insulating body which insulates the metal terminal and the battery module case one from the other. The insulating body is provided with a drop preventing section which abuts at least a lower surface of the expanded section of the bolt and prevents the bolt from dropping from the metal terminal.
US08802276B2 Secondary battery
A secondary battery includes an electrode assembly having a first electrode, a second electrode, and a separator located between the first electrode and the second electrode; a first collector plate electrically coupled to the first electrode, wherein the first collector plate has a first fuse hole and includes at least one first reinforcement protrusion having a first reinforcement groove and being spaced from the first fuse hole; a second collector plate electrically coupled to the second electrode; a case housing the electrode assembly, the first collector plate and the second collector plate, the case having an upper opening; and a cap assembly sealing the upper opening of the case.
US08802275B2 Battery module
A battery module includes a plurality of unit cells, each unit cell having a first terminal and a second terminal, the plurality of unit cells including at least a first unit cell and a second unit cell, and a bus bar electrically connecting the first terminal of the first unit cell to one of the first and second terminals of the second unit cell, the bus bar including an insertion part therein, the insertion part being configured to receive a sensing member and connect the sensing member to the bus bar.
US08802269B2 Flat nonaqueous secondary battery
A flat nonaqueous secondary battery with improved reliability is provided. The flat nonaqueous secondary battery (1) includes an electrode assembly disposed in a space formed by an exterior case (2) and a seal case (3). The electrode assembly includes a plurality of positive electrodes (5) and a plurality of negative electrodes (6) alternately stacked upon each other and a separator (7). The separator (7) has a joint (7c) formed by welding together at least a portion of its periphery. When the separator (7) and the positive electrode (5) are measured along a cross section in their thickness direction, the ratio A/B of the shortest distance A between the end of the joint (7c) of the separator (7) facing the positive electrode (5) and the outer periphery of the positive electrode (5) sandwiched by the separator (7) to the thickness B of the positive electrode (5) is not smaller than 1.
US08802265B2 Method for storing electrical energy in ionic liquids
A redox flow battery having an electrolyte which includes at least one ionic liquid, wherein the anion of the ionic liquid(s) is selected from a halide, a phosphate, a nitrite, a nitrate, a sulfate, a hydrogensulfate, a carbonate, a hydrogencarbonate, a phosphonate, a phosphinate, a sulfonate, a carboxylate, an imide, a methide and mixtures thereof.
US08802263B2 Battery pack and method of manufacturing the same
A battery pack and method of manufacturing the same, the battery pack including a battery, and a plurality of metal cases surrounding the battery, wherein the plurality of metal cases includes a first metal case and a second metal case and the first and second metal cases are welded to each other.
US08802251B2 Thermoelectric conversion device using a solvating material
The present invention relates to a thermoelectric conversion device using a solvating material, the device comprising: a cell with a closed structure, comprising a metal ammonia or metal amine compound as a solvating material; a polarization or porous separation membrane; and a heating unit, which prevents the outflow of the solvating material and thus maintains the solvating material in a reversible state.
US08802250B2 Fuel cell bypass diode structures and attachment methods
A fuel cell system includes a fuel cell stack which includes a plurality of fuel cells contacted in series by a plurality of interconnects. The various embodiments provide systems and methods for coupling a fuel cell stack with an electric bypass module within a hot zone. The bypass module may include elements for conducting a current between interconnects in a fuel cell stack and thereby bypass a failed fuel cell that has become a resistive parasitic load.
US08802245B2 Polymer composition and polymer light emitting device
A polymer composition comprising 1 to 99 wt % of a copolymer (A) and 99 to 1 wt % of a copolymer (B); the polymer composition used as a light emitting material of a light emitting device having high performances; Copolymers (A) and (B) being copolymers showing fluorescence in the solid state and having a polystyrene-reduced number average molecular weight of 103 to 108, and containing a repeating unit (a) and a repeating unit (b); Copolymer (A) has a relation of 100>XaA>5, where XaA (%) is a percentage of the mol number of repeating unit (a) based on the sum of the mol numbers of repeating units (a), and Copolymer (B) satisfies a relation of XaB≦XaA−5, where XaB (%) is a percentage of the mol number of repeating unit (a) based on the sum of the mol numbers of repeating units (a) and (b).
US08802242B2 Clad plate
A clad plate includes an aluminum plate and a hard metal plate joined together at side end surfaces thereof. Side end surfaces of an aluminum plate and a hard metal plate are jointed together via a nickel layer by pressure welding. A ridge and a groove formed in the side end surface of the aluminum plate are respectively engaged and joined, via the nickel layer, to a groove and a ridge formed in the side end surface of the hard metal plate, and an end portion of the nickel layer extends beyond the rear end portion of the side end surface of the aluminum plate and is jointed to the plate surface of the aluminum plate with the end portion exposed thereon. The average width W of the exposed portion of the nickel layer exposed on the plate surface is preferably from about 0.2 mm to about 1.5 mm.
US08802237B2 Entry sheet for drilling holes in printed circuit boards
An entry sheet comprising polymer material for drilling printed circuit boards is provided. The entry sheet is suitable for use with a broad range of diameters, including commonly available drill diameters. The entry sheet comprises an adhesive epoxy configured to, among others, resist drill deflection, resist mechanical damage, and reduce to dust such that the entry sheet may increase drilling accuracy, protect printed circuit board from damage, minimize entry burrs, and may addresses other issues such as fliers, bird nesting, and the like.
US08802236B2 Durable transparent intelligent coatings for polymeric transparencies
A hard, transparent coating for a substrate and associated method for coating is disclosed. The coating includes alternating layers of a soft coating and a hard coating. The coating further includes a sensor. The electrical resistivity of the sensor may be measured to determine if the coating has been degraded. The coating may further include a hydrophobic outer layer.
US08802233B2 Meta-type wholly aromatic polyamide fiber excellent in high-temperature processability, and method for producing the same
Upon producing a meta-type wholly aromatic polyamide fiber by wet spinning a polymer solution containing a meta-type wholly aromatic polyamide containing a m-phenylenediamine isophthalamide skeleton as a major component, and an amide solvent containing a salt, (1) the polymer solution is ejected into a coagulation bath containing an amide solvent and water and containing a salt at a low concentration to coagulate as a porous thread body (fibrous material), (2) which is subsequently stretched in a plastic stretching bath containing an aqueous solution of an amide solvent, (3) is rinsed with water and then subjected to a heat treatment in a saturated steam atmosphere, and (4) is then subjected to a dry heat treatment, so as to produce a novel meta-type wholly aromatic polyamide fiber that contains an extremely small amount of a solvent remaining in the fibers, contains a small amount of a volatile substance harmful in a heat treatment step at a high temperature, is capable of suppressing coloration of a fiber product, and is capable of providing a product with high performance and high quality.
US08802232B2 Powder coated roving for making structural composites
A powder coated roving material for making structural parts is provided. The powder coated roving includes a bundle of fibers at least substantially coated with a powder coating material. The bundle is formed of a plurality of inner fibers and a plurality of outer fibers surrounding the inner fibers. The size composition maintains the fibers in a bundled orientation during processing and releases the fibers during molding. The size composition includes an epoxy resin emulsion containing at least one surfactant and a solid epoxy resin having an epoxy equivalent weight from about 450 to about 950, at least one epoxy silane coupling agent, at least one non-ionic lubricant, at least one cationic lubricant, and at least one organic acid. In addition, the size composition may have an acetone solubility from about 30% to about 75%. A method of making a composite roving is also provided.
US08802231B2 Insulating coating material and insulated wire using the same
An insulating coating material includes a polyamide-imide resin insulating coating material, and surface-treated inorganic fine particles dispersed in the polyamide-imide resin insulating coating material. A viscosity measured by an E-type viscometer is 1000 to 4000 mPa·s at 30° C. and at a shear rate of 200 s−1 and 4000 to 12000 mPa·s at 30° C. and at a shear rate of 1 s−1. An insulated wire includes a rectangular conductor, and an insulating layer formed on the rectangular conductor and including the insulating coating material.
US08802230B2 Electrically-insulative coating, coating system and method
An electrically-insulative coating for minimizing an electrical conductivity of a metal substrate includes a polymer component formed from a monomer precursor, and a powder component substantially dispersed in the polymer component. The powder component is present in the electrically-insulative coating in an amount of from about 5 parts to about 80 parts by weight based on 100 parts by weight of the electrically-insulative coating. The electrically-insulative coating does not substantially degrade when exposed to from about 100 V to about 330 V at a temperature of from about −50 ° C. to about 500 ° C., and has a dielectric strength of at least about 2,000 VAC/mil. An electrically-insulative coating system and a method of forming an electrically-insulative coating on a metal substrate are also disclosed.
US08802226B2 Manufacturing process for coated polyester film
A method of preventing or minimizing the formation of haze in a biaxially oriented polyester film during the annealing of said film above its glass transition temperature, said method comprising: (a) selecting a biaxially oriented polyester film having glass transition temperature (Tg (° C.)); (b) disposing a coating on one or both surfaces of said biaxially oriented film; (c) annealing said coated biaxially oriented polyester film at a temperature above its glass transition temperature, wherein said coating composition is selected from: (i) an organic coating comprising a low molecular weight reactive diluent; an unsaturated oligomer; a solvent; and a photoinitiator; (ii) an organic/inorganic hybrid coating comprising a low molecular weight reactive component and/or an unsaturated oligomeric component; a solvent; and inorganic particles, and optionally further comprising a photoinitiator; (iii) a predominantly inorganic hardcoat comprising inorganic particles contained in a polymerisable predominantly inorganic matrix; and (iv) a composition comprising a cross-linkable organic polymer selected from polyethylene imine (PEI), polyester and polyinylalcohol (PVOH), and a cross-linking agent.
US08802218B2 Construction of loft in quilted materials
An insulating product utilizing pillars and arches to increase loft without increasing the thickness of the padding.
US08802214B2 Non-random array anisotropic conductive film (ACF) and manufacturing processes
Structures and manufacturing processes of an ACF array using a non-random array of microcavities of predetermined configuration, shape and dimension. The manufacturing process includes fluidic filling of conductive particles onto a substrate or carrier web comprising a predetermined array of microcavities, or selective metallization of the array followed by filling the array with a filler material and a second selective metallization on the filled microcavity array. The thus prepared filled conductive microcavity array is then over-coated or laminated with an adhesive film. Cavities in the array, and particles filling the cavities, can have a unimodal, bimodal, or multimodal distribution.
US08802210B2 Blow moulded articles of bimodal polyethylene
The invention relates to A process for the polymerisation of ethylene to produce a polyethylene resin in at least two slurry loop reactors connected to each other in series, the resin having a bimodal molecular weight distribution, a molecular weight distribution MWD of at least 7.0, an HLMI of from 1 to 100 g/10 min, and a density of from 0.935 to 0.960 g/cm3, wherein in one reactor 30 to 47 wt % based on the total weight of the polyethylene resin of a high molecular weight (HMW) polyethylene fraction is produced having an HL275 of from 0.05 to 1.8 g/10 min (the equivalent of HLMI of from 0.01 to 1.56 g/10 min), a density of from 0.925 to 0.942 g/cm3 and an MWD of at least 5.0, and in the other reactor a low molecular weight (LMW) polyethylene fraction is produced having an HLMI of from 10 to 1500 g/10 min and a density of from 0.960 to 0.975 g/cm3, in the presence of a Ziegler-Natta catalyst system.
US08802198B2 Flux and fluxing bath for hot dip galvanization, process for the hot dip galvanization of an iron or steel article
The present invention generally relates to a flux for hot dip galvanization comprising from: 36 to 80 wt. % (percent by weight) of zinc chloride (ZnCl2); 8 to 62 wt. % of ammonium chloride (NH4C); from 2.0 to 10 wt. % of a least one of the following compounds: NiCl2, MnCl2 or a mixture thereof. The invention further relates to a fluxing bath, a process for the hot dip galvanization of an iron or steel article as well as to the use of said flux.
US08802187B2 Solar cell and process for producing the same
The present invention provides a method of manufacturing a solar cell, comprising forming a buffer layer comprising a group-III nitride semiconductor on a substrate using a sputtering method, and forming a group-III nitride semiconductor layer and electrodes on the buffer layer. The group-III nitride semiconductor layer is formed on the buffer layer by at least one selected from the group consisting of the sputtering method, a MOCVD method, an MBE method, a CBE method, and an MLE method, and the electrodes are formed on the group-III nitride semiconductor layer.
US08802186B2 Method and apparatus for load-locked printing
The disclosure relates to a method and apparatus for preventing oxidation or contamination during a circuit printing operation. The circuit printing operation can be directed to OLED-type printing. In an exemplary embodiment, the printing process is conducted at a load-locked printer housing having one or more of chambers. Each chamber is partitioned from the other chambers by physical gates or fluidic curtains. A controller coordinates transportation of a substrate through the system and purges the system by timely opening appropriate gates. The controller may also control the printing operation by energizing the print-head at a time when the substrate is positioned substantially thereunder.
US08802181B2 Low sodium salt composition
The present invention relates to a low sodium salt composition and the methods used to make it. The low sodium salt composition includes sodium chloride and a modified chloride salt composition. The modified chloride salt composition includes a homogenous amalgamation of chloride salt, food grade acidulant, and carrier, which does not contain sodium chloride. The modified chloride salt composition may be combined with sodium chloride to form a low sodium salt composition. The modified chloride salt composition may be enhanced to increase particle size.
US08802177B2 Soluble oat or barley flour and method of making utilizing a continuous cooker
Preparing soluble oat or barley flour in one-step using an extrusion (continuous cooking) process to dextrinize and gelatinize cook the oat or barley flour.
US08802175B2 Quick cooking barley and process
A method for processing barley to make a quick-cooking barley product is described. Barley is pearled to remove hulls, and is then precooked to raise the moisture content and gelatinize starch in a single step. The precooked barley is dried in two stages. The first drying stage causes case hardening of the kernel, while the second stage heats moisture trapped within the kernel to cause steam expulsion from the hardened kernel and final drying of the precooked barley. The resulting dried product is a porous kernel that may be shipped, stored, and easily reconstituted by the end user.
US08802174B2 Method of preparing coffee infusions and machine for achieving same
The present invention relates to a machine for preparing coffee infusions by means of a liquid under pressure, in particular water under pressure, the machine comprising: a pump assembly (11) arranged to raise the pressure of the liquid outgoing from the pump assembly up to a preset pressure value (PI); one or more dispensing units (14) connected to the pump assembly, each dispensing unit (14) being arranged to dispense the coffee infusion; one or more pressure managing devices (20), each managing device (20) being connected to a certain dispensing unit (14). In the machine (10), the pressure managing device (20) includes a first duct (15) and at least one second duct (16) that are connected in parallel, have a common outlet and are arranged to supply the dispensing unit (14), during the coffee infusion preparation, with liquid at different pressures. The invention further concerns the pressure managing device (20) and a method of preparing the coffee infusion, including dynamically modifying the pressure during the infusion preparation.
US08802173B2 Process for coating frozen products
A process for coating frozen confection stick products (20) is provided, the process comprising providing a chamber (2) having two open ends (3,4), two sides (5,6) and a base (7); providing at least one pair of apertures (10A-10D), wherein one aperture of each pair is located on each side of the chamber, and wherein the apertures are vertical slots; supplying a liquid coating material to each aperture thereby forming curtains of the liquid coating material (14A-14D); and conveying the frozen confection (20) through the chamber with the stick uppermost so that the frozen confection passes through the curtains of coating material. An apparatus for operating the process is also provided.
US08802169B2 Process for producing sparkling alcoholic drink and sparkling alcoholic drink produced by using the process
It is an object of the present invention to provide a method of producing a foaming alcoholic beverage such as beer, low-malt beer, and a beer-flavored foaming alcoholic beverage obtained by producing, without using any kind of barley (e.g., barley, wheat, malt), a pre-fermentation liquid using at least a syrup containing sources of carbon, sources of nitrogen, hops and water as raw materials and fermenting the pre-fermentation liquid with use of brewers' yeasts, wherein germinated grains are used; to thereby increase fermentability and attain superior flavor and improved foam quality. It is also an object of the present invention to provide an alcoholic beverage manufactured by the aforementioned method.Especially, a germinated material, which is obtained by selecting at least one material from a group consisting of corns, potatoes, peas, soy beans, black soy beans, adzuki beans, Taisho Kintoki beans and unpolished rice and germinating the selected material, is used as a part of a raw material of the aforementioned foaming alcoholic beverage. Thereby, a foaming alcoholic beverage can be provided with improved foam quality, flavor quality and fermentability unique to the foaming alcoholic beverage.
US08802167B2 Use of Eclipta prostrata and other PPAR-gamma inhibitors in cosmetics and compositions thereof
The present invention describes compositions and methods for improving the appearance of skin, particularly, treating, ameliorating, preventing, delaying, and/or improving one or more signs of excess accumulation and/or production of subcutaneous fat, such as cellulite, and conditions related thereto, by topically applying compositions comprising Eclipta prostrata extracts or other anti-lipid agents.
US08802166B2 Composition for hair and body application
The inventive compositions comprise in a deionized water base, a composition comprising: a preservative, a chelating agent; one or more moisturizer and hydrolyzed keratin protein; an antioxidant selected from the group consisting of citric acid and a vitamin E salt; and an emulsifier-water trap selected from the group consisting of cetearyl alcohol and glyceryl stearate; and PEG-40 castor oil. The composition, which is in liquid form, may be applied in the form of a spray or mist by dipping the affected area in the liquid or by pouring a small amount of the liquid onto the hair or body to be treated.
US08802161B2 Herbal composition and method of use for the treatment of cancer
The invention describes a nutraceutical composition and method for preventing/treating cancer or augmenting chemotherapy in advanced stage malignancies; comprised of [1] tumoricidal herbs; beth root, galbanum, gromwell root, wild yam, balm of gilead bud, frankincense, [2] an antiproliferative herb; speranskia [3] a natural lactic acid dehydrogenase (LDH) inhibitor, 2′,3,4′5,7-pentahydroxyflavone or cinnamon, [4] alkalizing agents: calcium, magnesium, potassium or bicarbonate salts, barley grass, chlorella and spirulina [5] at least one quinone and [6] at least one agent capable of maximizing oxidative mitochondrial function preferably riboflavin, 6,7-Dimethyl-8-(1-D-ribityl)lumazine, ribitol, 5,6-dimethylbenzimidazole, tetrahydrobiopterin and a pharmaceutically acceptable carrier.
US08802156B2 Pharmaceutical forms for the release of active compounds
A pharmaceutical composition containing a sulfated glycosaminoglycan drug and a polycationic polymer or copolymer wherein the proportion of ammonium groups in the pharmaceutical composition is between 0.01-2.0 μmol ammonium groups/mg pharmaceutical composition, the proportion of glycosaminoglycan in the pharmaceutical form is between 15% to 50% w/w, and the pharmaceutical composition possesses a moisture content of 10% wt or less. A pharmaceutical dosage form containing the pharmaceutical composition, and their use for the treatment of diseases or disorders therapeutically responsive to the glycosaminoglycan.
US08802155B1 Iminosugar in crystalline form
Iminosugar, which possesses known activity as a glycosyltransferase inhibitor, and is used, for example, in the treatment of Gaucher's disease, in crystalline form, a process for its preparation and a pharmaceutical composition thereof.
US08802149B2 Systems and processes for spray drying hydrophobic and hydrophilic components
Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions of the components and spray drying them simultaneously in a spray dryer. The hydrophilic and hydrophobic component are separately dissolved in separate solvents and directed simultaneously through a nozzle, usually a coaxial nozzle, into the spray dryer. The method provides dry powders having relatively uniform characteristics.
US08802147B2 Controlled release of biologically active compounds
The present invention relates to biodegradable polymers (e.g., polyesters and polyester amides) derived from functionalized biologically active compounds that can provide site specific delivery of bioactive compounds upon biodegradation in a controlled manner.
US08802145B2 Highly porous, fast-disintegrating solid dosage form and its way of manufacturing comprising the preparation of a powder and a freezedrying step
The invention relates to a method of manufacture of fast-disintegrating solid dosage forms, characterized in that one or more structure building components in mixed solid powder form are dosed into cavities of blister packs or moulds, the remaining components dissolved in water dosed and added to the powder to form a moistened, plasticized mass, frozen to below −20° C., and the water sublimed in high vacuum. In this way solid dosage forms are obtained with a similar porous structure as usually result from freeze drying processes, but the process requires much less water, which means considerably less time and less energy.
US08802142B2 Pharmaceutical compositions comprising levetiracetam and process for their preparation
The present invention relates to a pharmaceutical composition comprising levetiracetam as active ingredient and 2.0 to 9.0% per weight of disintegrant, 0.0 to 3.0% per weight of gliding agent, 0.5 to 6.0% per weight of binder, and 0.0 to 1.0% per weight of lubricant, with respect to the total weight of the pharmaceutical composition, and to a process for its preparation.
US08802139B2 Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
An oral pharmaceutical composition comprises multiple populations of at least one of beads, pellets, tablets and granules provided in a capsule, the composition comprising: a first population of a pharmaceutical active comprising a pharmaceutical active substance releasable at a first rate; a population of a basic substance; and a second population of a pharmaceutical active comprising a pharmaceutical active substance releasable at a second rate. In another embodiment, the oral pharmaceutical composition comprises multiple populations of at least one of beads, pellets, tablets and granules provided in a capsule, the composition comprising: a population of a pharmaceutical active; a population of a basic substance; a population of enteric coated pharmaceutical active; and a population of enteric coated basic substance. The composition can provide multiple site specific delivery of a pharmaceutical active in a rapid, delayed and/or sustained release manner into the plasma.
US08802137B2 Sustained release of antiinfectives
Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 μm. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.
US08802136B2 Transdermal patch incorporating active agent migration barrier layer
Devices for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch. One outer layer functions as the primary adhesive layer for adhering the patch to the host. The other inner layer contains at least one active agent to be administered to the host. The inner layer is bonded to the outer layer through an opening provided in an interposed active agent impermeable release layer. The release layer separates a circumferential portion of the active agent containing inner layer from the outer adhesive layer to inhibit migration of the active agent therebetween.
US08802133B2 Silicone scar treatment preparation
Disclosed is 1) a method for greatly increasing the solubility of useful actives in siloxane matrix-forming preparations, and 2) the associated preparations, themselves. Volatilizing coagents are utilized to give novel gels containing heretofore siloxane-insoluble additives.
US08802132B2 Anti-microbial tissue paper and process to manufacture same
An antimicrobial paper includes a paper web having a grammage between 10 and 60 grams per square meter, a cationizing agent in a concentration ranging between 0.05 wt % and 5 wt %, an antimicrobial agent in a concentration ranging between 0.01 wt % and 3 wt %, the antimicrobial agent and the cationizing agent being added on the paper web having a consistency above 15 wt %, the antimicrobial paper having an antimicrobial agent release of above about 0.01 wt % when wetted.
US08802131B2 Devices and methods for delivering active agents to the osteomeatal complex
Described here are devices, methods, and kits for treating sinusitis and related respiratory conditions by locally delivering active agents to the osteomeatal complex over a sustained period of time. The devices may be passively fixed within the osteomeatal complex and/or include one or more features that actively fix it within the osteomeatal complex. The devices may optionally include a portion that extends into a sinus ostium, sinus cavity, and/or the nasal passage to deliver an active agent.
US08802128B2 Steroid-containing sustained release intraocular implants and related methods
Biocompatible intraocular implant systems are formulated for discontinuous or intermittent release of therapeutic levels of a therapeutic agent (such as a steroid) to minimize development of side effects associated with continuous or long term use of such agent. The implant system may comprise one or more implant, and preferably, although not necessarily, also contains an auxiliary agent having an activity effective to lessen at least one side effect associated with said therapeutic agent compared to the use of an otherwise identical implant system lacking said auxiliary agent. The implants containing the therapeutic agent and auxiliary agent may be placed in an eye to treat one or more ocular conditions while reducing the ocular side effects otherwise accompanying the use of such therapeutic agent.
US08802127B2 Risperidone-containing PLA:PGA implants and methods of use thereof
The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.
US08802125B2 Controlled-delivery system of pharmacologically active substances, preparation process and medical use thereof
The invention concerns a system for biocompatible drug release comprising: (i) a polymer matrix; (ii) an inorganic component located inside said matrix and characterized by a lamellar structure with a net positive or negative charge able to intercalate (iii) a pharmacologically active principle into said lamellar structure, by establishing an ionic type of bond with it and thereby obtaining an intercalation compound. The preparation process for the release system comprises the stages of: treating the lamellar solid in such a way as to give it a net positive or negative charge, then combining it with the chosen active principle, also in an ionic form, to obtain an intercalation compound which is then mixed with the polymer matrix. The release system can be employed in making medical devices, like sutures, membranes, osteosynthesis plaques, multilayered devices, gels and drug delivery systems.
US08802124B2 Erodible vessel sealing device without chemical or biological degradation
The present invention provides a dissolvable medical sealing device (3, 4; 6, 7; 9) for closing a wound in vessel. A sealing device (3, 4, 6, 7, 9) according to the invention is made of a material that dissolves by means of physical processes, rather than by means of chemical or biological processes. Such a sealing device (3, 4; 6, 7; 9) can be made of polyethylene glycol, polypropylene glycol, copolymers containing ethylene glycol and propylene glycol, polyvinyl alcohol or polyvinyl pyrolidone, or any combinations thereof.
US08802123B2 Endosseous implant
Endosseous implant to be applied to a human or animal bone, wherein the surface of the implant is made from titanium or a titanium alloy, said implant having a smooth or rough surface texture, which is characterized in that said surface has been treated with at least one selected organic phosphonate compound or a pharmaceutically acceptable salt or ester or an amide thereof; process for producing said implants.
US08802116B2 Poloxamer emulsion preparations
An emulsion composition comprising: an aqueous component, a non-ionic block copolymer, and an oil wherein the copolymer comprises at least 10% by weight of the composition.
US08802110B2 Influenza treatment and/or characterization, human-adapted HA polypeptides; vaccines
The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.
US08802106B2 Peptide compositions and methods for inhibiting herpesvirus infection
The present invention provides an isolated peptide having an amino acid residue sequence that comprises at least one human cytomegalovirus glycoprotein B (HCMV-gB) sequence segment, each HCMV-gB sequence segment consisting of at least 8 and not more than 60 consecutive amino acid residues from residues 146 to 315, residues 476 to 494 of SEQ ID NO: 1, or from a sequence variant of residues 146 to 315 or 476 to 494 of SEQ ID NO: 1 that has at least 70% sequence identity thereto. The peptides of the invention are useful for treating, preventing, or inhibiting a herpesvirus (e.g., Herpes Simplex Virus-1, Human Cytomegalovirus, and the like) infection in a subject.
US08802105B2 Antibacterial compositions
The present invention relates to oral antibacterial compositions comprising trihydroxybenzoate derivatives, e.g., useful for the treatment of gum diseases (e.g., gingivitis or periodontitis) and to methods of using such compositions.
US08802102B2 Formulation of human antibodies for treating TNF-α associated disorders
A liquid aqueous pharmaceutical formulation is described which has a high protein concentration, a pH of between about 4 and about 8, and enhanced stability.
US08802101B2 Formulation of human antibodies for treating TNF-α associated disorders
A liquid aqueous pharmaceutical formulation is described which has a high protein concentration, a pH of between about 4 and about 8, and enhanced stability.
US08802098B2 Methods of promoting antitumor immunity by administering CD40 agonists and alpha-galactosyl ceramide
Adjuvant combinations comprising at least one NKT activator, such as alpha-galactosylceramide (α-Gal-Cer) or iGb3, a CD40 agonist and optionally an antigen are disclosed. The use of these immune adjuvants for treatment of various chronic diseases such as cancers is also provided.
US08802094B2 Method of reducing phosphate absorption by administering orally an IgY anti-intestinal sodium phosphate cotransporter type 2B antibody
A method for reducing phosphate absorption in a human or non-human animal subject at risk of developing or having developed hyperphosphatemia is disclosed. The method includes the step of administering orally to the subject an anti-intestinal sodium phosphate cotransporter type 2B (Npt2B) antibody in an amount effective to reduce or maintain the serum phosphate concentration in the subject.
US08802085B2 Compositions for topical treatment of medical conditions including wounds and inflammation
A method for treating a patient suffering from a wound, ulcer, or inflammation includes providing a topical formulation comprising a carrier and a combination of active ingredients that includes at least one retinoid and at least one blood vessel dilator, and applying the topical formulation to the skin of the patient to cause healing, accelerated healing or prevention of the wound, ulcer or inflammation. Additional active ingredients may include a promoter of mitochondrial function or an antioxidant.
US08802083B2 Method of making platelet and poly-beta-1,4-N-acetylglucosamine fiber compositions
The present invention relates to compositions comprising complexes of human cells and polymer fibers and methods of their use for therapeutic purposes. Methods of making such compositions are also provided. The present invention encompasses compositions comprising poly-β-1→4-N-acetylglucosamine polymers and stored platelets and their use for promoting wound healing and achieving hemostasis.
US08802077B2 Bifidobacterium longum NCC2705 (CNCM I-2618) and immune disorders
The present invention generally relates to the field of preventing and/or treating inflammatory and infectious disorders, in particular by boosting the endogenous antimicrobial defences. One embodiment of the present invention is the use of B. longum NCC2705 (deposit number CNCM 1-2618) for use in the treatment or prevention of disorders related to the immune system including infections.
US08802076B2 Compositions and methods for modulating an immune response
Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. a cytokine. The cytokine can be selected from the group consisting of TNF, IL-12, IL-2, IL-23, IL-1α, IL-10, IL-18, and combinations thereof. Further provided are methods of making a nanoparticle comprising mixing a first composition comprising heparin with a second composition comprising chitosan in the presence of at least one cytokine to form a third composition. Further provided are methods of modulating an immune response comprising co-administering to a subject an antigen or vaccine with nanoparticles comprising heparin, chitosan, and at least one cytokine.
US08802072B2 Biocompatible adhesive materials and methods
Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.
US08802070B2 Compositions containing a phospholipid, a nonionic surfactant, and an anionic silicone for lifting color and/or imparting shine onto keratinous substrates
The present invention is drawn to a composition and method for lifting color and/or imparting shine onto keratinous substrates, the composition containing: (a) at least one phospholipid; (b) at least one nonionic surfactant; (c) at least one anionic silicone; and (d) at least one oxidizing agent. The compositions of the present invention may optionally contain at least one thickening agent, at least one alkaline agent, at least one fatty substance other than a fatty acid, and at least one salt.
US08802068B2 Non-weighing hair preparations
An agent for treating keratin-comprising fibers, in particular human hair, which includes in a cosmetic carrier at least one cyclic siloxane, at least one C8 to C30 alkyl PEG/PPG dimethicone, and at least one cationic protein hydrolysate.
US08802064B2 Inhibitors of fatty acid amide hydrolase
Provided herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates or prodrugs thereof, or mixtures thereof, wherein Z1, Z2, X1, X2, X3, R1, R2, R3, m and n are defined herein. Also provided are pharmaceutically acceptable compositions that include a compound of formula I and a pharmaceutically acceptable excipient. Also provided are methods for treating FAAH-mediated disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound or composition of the present invention.
US08802063B2 Cosmetic composition
Provided are cosmetic and personal care compositions having film-formers that are copolymers of olefins and cycloolefins, such as ethylene/propylene/ethylidenenorbornene terpolymers. The compositions may provide long wearing, transfer resistant and/or highly comfortable films on the lips, skin, hair and nails.
US08802060B2 Foamable fluoride oral care composition
A dental fluoride foam composition comprising an aqueous solution of a water soluble fluoride ion releasable salt, a surfactant selected from the group consisting of nonionic surfactants, zwitterionic surfactants, betaine surfactants and mixtures thereof; and an orally compatible acidifying agent in an amount sufficient to adjust the pH of the composition to about 3 to about 5. The composition is stable at low temperatures and is a clear solution substantially free of precipitates when held at 4.4° C. for 12 hours. When dispensed from a container into the trough of a dental tray, the composition forms a low density, rapidly collapsible foam which substantially liquefies in about 1 minute after being dispensed from the foam generating container and placed in contact with a patient's teeth.
US08802059B2 Algal extract-based composition for oro-dental use
An algal extract-based composition for oro-dental use is provided. This composition comprising a mixture of algae with at least Ascophyllum nodosum and Fucus spp. is characterized in that said mixture of algae has a proportion of Ascophyllum nodosum of at least 90% of the weight of the mixture and that the proportion of Fucus spp. is at most 10% of the weight of the mixture, and in that said extract is combined with a natural surfactant and/or with a zeolite or a mixture of zeolites. Uses of said composition, in particular for dental prevention and/or care, are also provided. Applications in the oro-dental field, both preventively and curatively.
US08802055B2 Use of the spin crossover complex [mx+(LY)HW]AN)Z as a magnetic resonance imaging contrast agent
A method for magnetic resonance imaging of a human or animal body includes providing a spin crossover complex having the general formula [Mx+(Ly)Hw]AN)z wherein, MX+ is a positively charged metal ion, Ly is a heteroaromatic ligand containing at least one nitrogen atom in its ring system, AN is a negatively charged inorganic anion, w is 0, 1 or 2, x is 2 or 3, y is 2 or 3, and z is 2, 3 or 4. The spin crossover complex is applied as a contrast agent in a magnetic resonance imaging of the human or animal body.
US08802046B2 Granular polycrystalline silicon and production thereof
Granular polycrystalline silicon is disclosed, which has a convexity of 0.850-1.000 and a chlorine content of 10-40 ppmw. Also disclosed is a process for producing granular polycrystalline silicon in a fluidized bed reactor, which includes: (a) fluidization of silicon seed particles by gas flow in a fluidized bed heated by a heating apparatus, (b) addition of a silicon- and halogen-containing reaction gas resulting in pyrolytic deposition of elemental silicon on heated seed particle surfaces, (c) forming the granular polycrystalline silicon, (d) removing from the reactor particles and offgas containing hydrogen halide, and (e) metered addition of fresh seed particles. The hydrogen halide concentration in the offgas is determined as the controlled variable. The rate of metered addition of fresh seed particles and heating output of the heating apparatus are controlled as manipulated variables to keep the hydrogen halide concentration in the offgas within an above-defined range during operation.
US08802044B2 Purification structure including a catalysis system supported by a zircon in reduced state
The invention relates to a filtration structure, for filtering a gas coming from a diesel engine, which is laden with gaseous pollutants of the nitrogen oxide NOx type and with solid particles, of the particulate filter type, said filtration structure being characterized in that it includes a catalytic system comprising at least one noble metal or transition metal suitable for reducing the NOx and a support material, in which said support material comprises or is made of a zirconium oxide partially substituted with a trivalent cation M3+ or with a divalent cation M′2+, said zirconium oxide being in a reduced, oxygen-sub-stoichiometric, state.
US08802043B2 Method for controlling acidic compounds produced for oxy-combustion processes
The present invention relates generally to the field of emissions control and, in particular to a new and useful method and/or system by which to control, treat and/or mitigate various liquid-based acidic compounds that are produced during oxy-combustion (e.g., during a compression step and/or cooling step) from various gaseous acid compounds and/or gaseous acid precursor compounds (e.g., SOx, NOx, etc.). In one embodiment, the present invention relates to a method and/or system by which such one or more liquid-based acid compounds are recycled into the flue gases and/or into one or more of the emissions control and/or flue gas treatment equipment of an oxy-combustion power generation system.
US08802040B2 Method for extracting and separating light rare earth element
A target light rare earth element is separated from an aqueous solution containing two or more of La, Ce, Pr and Nd by contacting an organic phase containing an extractant with the aqueous solution in a counter-current flow multistage mixer-settler while adding an alkaline solution thereto, and contacting the organic phase with an acid aqueous solution for back-extracting the target element. The extractant is a dialkyl diglycol amic acid having formula: R1R2NCOCH2OCH2COOH wherein R1 and R2 are alkyl, at least one having at least 6 carbon atoms.
US08802036B2 Reaction cassette and assay device
A reaction cassette for biochemical assay, a biochemical assay device including a first space configured to accommodate liquid, having a first opening and rounding edges, a direction of the first opening being directed upward. A second space includes a second opening, a direction of the second opening being perpendicular to the direction of the first opening, wherein the first space and the second space are disposed such that when the reaction cassette is rotated allowing the liquid to drain into the second space. A third space is located below the first space and having a third opening, a direction of the third opening being upward such that when the reaction cassette is reversibly rotated allowing the liquid to drain into the third space, wherein an array of bumps is disposed in the third space to create turbulence of the liquid. An inner partition wall, connected with the second opening and the third opening, acts as a liquid flow channel between the second space and the third space.
US08802033B2 Slicing device
The invention relates to a biological microglia comprising at least two pores having a size adopted to allow cells, cell aggregates, tissue or other biological material to pass through said pores, and one or several slicing beams separating said pores from each other, wherein biological material is split/sliced/cleaved into at least two parts when passing said microgrid, a slicing device, an apparatus comprising said slicing device as well as the use of said microgrid, slicing device and apparatus.
US08802032B2 Analyzer
This invention provides an analyzer that has a liquid dispense pipette dispensing liquids with higher accuracy and precision at higher speeds. The analyzer includes a drive mechanism having a stepping motor as a power source. The drive mechanism transmits power from a rotation output shaft of the stepping motor to a moving unit for executing a target motion via at least one power transmission unit. The amount of idling of the moving unit stemming from the stepping motor getting driven in reverse is calculated from the amount of movement of the moving unit, from the amount of pulses fed to the stepping motor, and from the amount of remaining pulses so as to perform motion control of the drive mechanism accordingly.
US08802031B2 Liquid dispensing device with a cap and a diaphragm
A liquid dispensing device comprising a hollow body having an opening in a lower end thereof for receiving liquid, and an integrated cap member arranged to sealingly close the body, said cap member comprising a resilient diaphragm which is deformable in a downwards direction. The device is suitable for use in automated apparatus.
US08802030B2 Capillary dispenser
A capillary dispenser includes at least one plunger-cylinder unit having a cylinder module and a plunger module disposed together on an axis. The cylinder module has an inner cylinder that is pneumatically connected to at least one capillary. The plunger module includes a hollow plunger that is closable on one side and is movable in the inner cylinder along the axis between an upper end position and a lower end position of the plunger module.
US08802027B2 Surfaces, including microfluidic channels, with controlled wetting properties
The present invention generally relates to coating materials, including photoactive coating materials. In some aspects of the invention, a sol-gel is provided that can be formed as a coating on a microfluidic channel. One or more portions of the sol-gel can be reacted to alter its hydrophobicity, in some cases. For instance, in one set of embodiments, a portion of the sol-gel may be exposed to light, such as ultraviolet light, which can be used to induce a chemical reaction in the sol-gel that alters its hydrophobicity. In one set of embodiments, the sol-gel can include a photoinitiator, that upon exposure to light, produces radicals. Optionally, the photoinitiator may be conjugated to a silane or other material within the sol-gel. The radicals so produced may be used to cause a polymerization reaction to occur on the surface of the sol-gel, thus altering the hydrophobicity of the surface. In some cases, various portions may be reacted or left unreacted, e.g., by controlling exposure to light (for instance, using a mask). Such treated surfaces within a microfluidic channel may be useful in a wide variety of applications, for instance, in the creation of emulsions such as multiple emulsions.
US08802021B2 Microwave integrated Soxhlet
The present invention relates to a new method of extraction of solid compounds by microwaves and to the apparatus used in said method.
US08802019B2 Reactor for carrying out an autothermal gas-phase dehydrogenation
A reactor includes an essentially horizontal cylinder for carrying out an autothermal gas-phase dehydrogenation of a hydrocarbon-comprising gas stream using an oxygen-comprising gas stream to give a reaction gas mixture over a heterogeneous catalyst configured as monolith. The interior of the reactor is divided by a detachable, cylindrical or prismatic housing, which is arranged in the longitudinal direction of the reactor and is gastight in the circumferential direction, into an inner region having one or more catalytically active zones, each having a packing composed of monoliths stacked on top of one another, next to one another and behind one another and before each catalytically active zone in each case a mixing zone having solid internals are provided and into an outer region, which is supplied with an inert gas, arranged coaxially to the inner region. A heat exchanger is connected to the housing at one end of the reactor.
US08802017B2 Honeycomb filter
In a honeycomb filter 20, partition portions and trapping layers are formed such that a pore volume difference that is obtained from pore distributions measured by mercury porosimetry and is a difference in volume of pores having a diameter of 10 μm or less between the downstream portion and the upstream portion of the honeycomb filter, is in the range of 0.01 cm3/g or more and 0.08 cm3/g or less. In the honeycomb filter, in the downstream portion, a first pore volume peak is present in a first pore diameter range of 2 μm or more and 9 μm or less and a second pore volume peak that is higher than the first pore volume peak is present in a second pore diameter range of 10 μm or more and 25 μm or less.
US08802016B2 Zoned catalyzed soot filter
The present invention relates to a catalyzed soot filter which comprises a wall flow substrate with an inlet end, an outlet end, a substrate axial length extending between the inlet end and the outlet end, and a plurality of passages defined by internal walls of the wall flow substrate wherein the plurality of passages comprise inlet passages having an open inlet end and a closed outlet end, and outlet passages having a closed inlet end and an open outlet end, and wherein the internal walls of the inlet passages comprise a zoned first inlet coating, the internal walls of the outlet passages comprise a zoned first outlet coating, and wherein the first inlet coating and the first outlet coating are present on the wall flow substrate at a coating loading ratio of less than 0.5.
US08802013B2 Prefabricated vol-oxidizer for spent nuclear fuel for convenient operation and maintenance
A vol-oxidizer for spent nuclear fuel is provided. The vol-oxidizer includes a reactor module in which the spent nuclear fuel is put and oxidized; a heating module to heat the reactor module to a high temperature; a utility module to control an inner state of the reactor module, being connected with the reactor module; a support module to support the heating module and the reactor module; a drive module to supply a driving force for transferring the spent nuclear fuel within the reactor module; a valve module to control discharge of the spent nuclear fuel being oxidized in the reactor module; and a collecting container module to collect the spent nuclear fuel being oxidized and discharged from the reactor module. The respective modules are assembled and disassembled with respect to one another.
US08802012B2 Method and device for producing a fragranced air stream
A method and device for producing a fragranced air stream for fragrancing rooms, objects or the like, wherein fragrance is applied to a strip-like fragrance carrier (4) which is moved in an evaporation duct (1) through which fresh air flows. The fragrance is applied onto the moving fragrance carrier (4) by means of specific spraying before the fragrance carrier (4) enters the evaporation duct (1), and the fragrance carrier (4) is discarded as waste after exiting the evaporation duct (1).
US08802011B2 Ion chromatography systems with flow-delay eluent recycle
A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods.
US08802005B2 Steel for surface hardening for machine structural use and part for machine structural use
The present invention is steel for surface hardening for machine structural use which contains, by mass %, C: 0.3 to 0.6%, Si: 0.02 to 2.0%, Mn: 0.35 to less than 1.5%, and Al: 0.01 to 0.5%, is restricted to B: less than 0.0003%, S: 0.0001 to 0.021%, N: 0.003 to 0.0055%, P: 0.0001 to 0.03%, and O: 0.0001 to 0.0050%, has a ratio Mn/S of Mn and S satisfying 70 to 30,000, has a balance of Fe and unavoidable impurities, and, when nitrided, then induction hardened, has a surface hardenability of a Vicker's hardness when tempered at 300° C. of 650 or more.
US08802003B2 Method for the production of a refractory filter
Method for the production of a closed edge refractory foam filter, by providing a reticulated foam substrate having at least one first surface for forming a side face of the filter and two opposed second surfaces for forming the through-flow faces of the filter, applying a liquid including an organic coating component to the first surface, solidifying the organic coating component to form a filter precursor having a continuous volatilizable coating on the first surface, and impregnating the filter precursor with a slurry containing particles of a refractory material, a binder and a liquid carrier. The impregnated filter precursor is dried and fired to form the filter having a closed edge.
US08802001B2 Customized luggage bag and vacuum forming method thereof
The instant disclosure relates to a customizable vacuum molding method for forming personalized luggage bags utilizing a customizable vacuum molding device having a main mold body (1) and a personalized pattern module (2) customized to suit a customer preference. The vacuum molding method comprising the steps of: 1) placing the personalized pattern module on a molding surface of the main mold body at a predetermined location; 2) placing a plastic luggage bag substrate onto the molding surface of the vacuum molding device and soften the substrate by heating; and 3) generating negative pressure in the vacuum molding device and stretching the plastic substrate onto the personalized pattern module on the molding surface of the main mold body while cooling the plastic substrate to form a personalized pattern. The instantly disclosed vacuuforming method provides a simple yet cost effective solution for manufacturing luggage bags having personalized patterns of a customer's choice.
US08801998B2 Method for producing a polyamide nanofiber product by electrospinning
In a method for producing a polyamide nanofiber product that contains PTFE particles, a spinning solution containing polyamide, PTFE, and a conductivity-increasing additive is provided and nanofibers are produced by electrospinning from the spinning solution. The conductivity-increasing additive is an acid-resistant additive; a surfactant additive; or an acid-resistant and surfactant additive and contains one or more organic salts. The polyamide nanofiber product with PTFE particles is used in filter media and is especially applied to a filter layer of cellulose or synthetic material.
US08801994B2 Forming the end portions of fibre reinforced thermoplastic composite tubes
A method and apparatus for forming at least one external annular flange (48 or 49) adjacent one end of a fiber reinforced thermoplastic tube (10) in which the tube (10) is mounted on a mandrel (12) and a first end portion of the tube is clamped in a collar (13) having at least one internal annular cavity (18 or 19) for forming a flange, a second end portion of the tube in the region (R1, R2) of the cavity is heated to soften the thermoplastic, and an axial load (L) is applied to the end of the tube by a piston (24) causing the softened tube to flow into the cavity (18, 19) in the collar (13) to form a flange on the tube.
US08801993B2 Polyurethane header formed directly on implantable electrical devices
This invention relates to electrical devices that are implantable inside an animal, including humans. The invention particularly relates to polyurethane headers mounted on the electrical devices to house electrical contacts. The polyurethane headers are formed by (a) mixing (i) a prepolymer comprising a silicon-containing diol of formula (I) in which R1, R2, R3 and R4 are independently selected from C1-6alkyl; R5 and R6 are independently selected from C1-6alkylene; R7 is C1-6alkylene, O, S or NR in which R is H or C1-6alkyl; and n is 1 to 3 and a diisocyanate; and (ii) a C2-12alkanediol; (b) injecting the mixture of the prepolymer and the C2-12alkanediol into a mold having a cavity shaped to form a header; (c) allowing the mixture to cure and form a polyurethane header within the mold; and (d) releasing the formed polyurethane header from the mold.
US08801992B2 Process for manufacturing a structural part made of an organic matrix composite and part obtained
A process for manufacturing a structural part made of an organic matrix composite including: production of a fibrous structure, forming a preform by braiding rovings of a fibrous material on a mandrel that includes a reinforcement in its axial extension, impregnation of the preform with an organic resin; and curing of this resin, the reinforcement, forming the cover, having a bore with an axis perpendicular to the axis for housing a connecting member. Barbs, some of which are projecting, are incorporated into the reinforcement over at least part of the surface of which lying on either side of the bore, the braiding being carried out around the barbs so that the rovings at least partly criss-cross around the barbs.
US08801985B2 Process of making a carbon fiber precursor fiber bundle
A production method for a carbon fiber precursor fiber bundle and a production apparatus of the carbon fiber precursor fiber bundle. A carbon fiber precursor fiber bundle that has a degree of intermingle of 1 m−1 or less between small tows, consists of substantially straight fibers without imparted crimp, a tow of which straight fibers has a moisture content of less than 10% by mass when housed in a container, and has a widthwise dividing capability to maintain a form of a single aggregate of tows when housed in a container, taken out from the container and guided into a firing step, and to divide into a plurality of small tows in the firing step by the tension generated in the firing step.
US08801983B2 Spacer mold and methods therefor
A hip spacer mold forming a spacer with a spacer stem connected to a spacer head has a stem portion for forming a spacer stem. The hip spacer mold also has a plurality of interchangeable head modules configured for alternatively forming spacer heads of a plurality of different predetermined sizes. The head modules are configured to be disposed adjacent the stem portion.
US08801977B2 Enhanced alpha particle emitter
A composition of matter that experiences an increase rate of radioactive emission is presented. The composition comprises a radioactive material and particles having affinity for Hydrogen or its isotopes. When exposed to Hydrogen, the composition's emission rate increases. Methods of production are also presented.
US08801973B2 Oxide sintered body and production method therefor, target, and transparent conductive film and transparent conductive substrate obtained by using the same
A target for sputtering or a tablet for ion plating, an oxide sintered body suitable for obtaining the same and a production method therefor, and a transparent conductive film having low absorption of blue light and low specific resistance, obtained by using the same are provided by an oxide sintered body having indium and gallium as an oxide, characterized in that an In2O3 phase with a bixbyite-type structure forms a major crystal phase, and a GaInO3 phase of a β-Ga2O3-type structure, or GaInO3 phase and a (Ga, In)2O3 phase is finely dispersed therein, as a crystal grain having an average particle diameter of equal to or smaller than 5 μm, and a content of gallium is equal to or higher than 10% by atom and below 25% by atom as atom number ratio of Ga/(In+Ga) or the like.
US08801972B2 Zinc chalcogenides, doped zinc chalcogenides, and methods of making
A process of preparing a zinc chalcogenide includes providing a solution of 8-hydroxyquinoline; a zinc precursor; and a reaction solvent; isolating a precipitate from the solution; and calcining the precipitate to form the zinc chalcogenide. Additionally, a polymer composite may include a polymer, bis(8-hydroxyquinolinato)zinc, and elemental sulfur or bis(8-hydroxyquinolinato)zM, wherein M is a metal ion and the value of z is equivalent to the oxidation state of the metal ion.
US08801964B2 Encapsulated polymer network liquid crystal material, device and applications
Polymer network liquid crystal materials have improved mechanical properties such as rigidity and hardness and substantially improved electro-optical performance. The PNLC material can be manufactured with an emulsion process so as to simplify substantially the manufacturing process. Each LC droplet can be configured with the polymer network extending substantially across the LC droplet, and the polymer network may comprise a material to lower substantially the switching voltage, such as a fluorinated acrylate that may interact with the liquid crystal so as to lower the surface tension of the LC droplet. The PNLC material may comprise an interfacial layer combined with the polymer network so as to decrease substantially the driving voltage.
US08801960B2 Lithium-containing complex oxide, non-aqueous secondary battery using the lithium-containing complex oxide, and method for producing the lithium-containing complex oxide
Because of the composition represented by General Formula: Li1+x+αNi(1−x−y+δ)/2Mn(1−x−y−δ)/2MyO2 (where 0≦x≦0.05, −0.05≦x+α≦0.05, 0≦y≦0.4; −0.1≦δ≦0.1 (when 0≦y≦0.2) or −0.24≦δ≦0.24 (when 0.2
US08801954B2 Curable inks comprising coated magnetic nanoparticles
There is provided novel curable ink compositions comprising coated magnetic metal nanoparticles. In particular, there is provided ultraviolet (UV) curable gel inks comprising at least the coated magnetic metal nanoparticles, one curable monomer, a radiation activated initiator that initiates polymerization of curable components of the ink, a gellant. The inks may also include optional colorants and one or more optional additives. These curable gel UV ink compositions can be used for ink jet printing in a variety of applications.
US08801949B2 Method of forming open-network polishing pads
The method forms forming an open-network polishing pad useful for polishing magnetic, semiconductor and optical substrates. The method provides a polymer sheet or film of a curable polymer and exposes the polymer sheet or film to an energy source to create an exposure pattern in the polymer sheet or film. The exposure pattern having elongated sections exposed to the energy source. After attaching the polymer sheet or film to an open-network substrate, the method removes polymer adjacent from the exposed polymer sheet or film of the intermediate structure with a solvent. This forms elongated channels through the polymer sheet or film in a texture pattern that corresponds to the exposure pattern with the open-network supporting the polymer. The elongated channels extending through the thickness of the polymer sheet or film to form the open-network polishing pad.
US08801948B2 TFT mask reduction
Embodiments of the present disclosure relate to display devices and methods for manufacturing display devices. Specifically, embodiments of the present disclosure employ a halftone photoresist layer useful for reducing a number of masks needed to manufacture TFT backplane (e.g., thin-film transistors (TFTs) with fringe-field shifting). The halftone photoresist layer defines two areas, one defining an etching area for a first layer (e.g., a common voltage layer) and the other defining an etching area for a second layer (e.g., an organic passivation layer).
US08801943B2 Method for manufacturing wraparound shield write head using hard masks
The present disclosure describes a method for manufacturing a full wraparound shield damascene write head through the implementation of a three layered (tri-layered) hard mask. According to an embodiment of the invention, the various layers of hard mask are used for different purposes during the formation of a write head. The wraparound shield head of the present invention exhibits improved physical characteristics that further result in improved performance characteristics. Use of the hard mask layers according to the present invention allows for use of manufacturing processes that can be more closely controlled than those processes used in other processes. For example, smaller dimension lithographic techniques can be used. Also, reliance on certain CMP processes is not necessary where the use of CMP processes is not as well-controlled as deposition or lithographic techniques as is possible using the present invention.
US08801942B2 Method for manufacturing a flexible intraocular retinal implant having doped diamond electrodes
A method for manufacturing an intraocular retinal implant including: providing a mold capable of supporting growth of a layer of doped diamond, the mold including, on one face, elements all depressed or all projecting with respect to the surface of the face, and constituting a pattern cavity for the electrodes of the implant which it is desired to obtain; producing the doped diamond electrodes by growing a layer of doped diamond in all or part of a space occupied by the pattern cavity elements; forming a first insulating layer on the face of the mold including the pattern cavity; producing interconnection lines by depositing an electrically conductive material at least in spaces not covered by the first insulating layer; forming a second insulating layer on the mold face including the pattern cavity, the second layer covering the interconnection lines, the first and second insulating layers forming a flexible plate of the implant; removing the mold.
US08801941B2 Method of removing oil from a mixture of tool steel swarf granular material and oil
A method of removing oil from a mixture of tool steel swarf granular material and oil. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. §1.72(b). As stated in 37 C.F.R. §1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.” The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.
US08801939B2 Ozonolysis reactions in liquid CO2 and CO2-expanded solvents
A method for increasing ozone concentration in a liquid can include: providing a gas having ozone; introducing the ozone-containing gas into a liquid, wherein the liquid and ozone combination has a temperature between about 0.8 and about 1.5 times the critical temperature of ozone; and increasing isothermally, the pressure of the ozone-containing gas above the liquid to about 0.3 to about 5 times the critical pressure of ozone so as to increase the ozone concentration in the liquid. The temperature is expressed in absolute units (Kelvin or Rankin). The method can be used for removing ozone from a gas or for purifying ozone. The liquid having a high ozone concentration can be used for ozonolysis of a substrate.
US08801938B2 Method and device for underwater recovery of products or pollutants
An apparatus, method, and system for recovering oil from a submerged oil source, wherein the system includes a submerged conduit having at least two openings, with a first opening capable of being located in proximity of a leak in order to capture leaking oil, and with a second opening capable of communicating captured leaking oil to another location. A natural gas separator, coupled to the submerged conduit separates the boiling vapor phase natural gas from the captured oil thereby outputting oil with water contaminant. An oil/water separator coupled to the natural gas separator then separates out the contaminant water, resulting in a processed recovered oil product for storage and subsequent refinement. The flow to capture the leak is induced by generating a lower pressure at nozzle in the conduit via power jet, air lift, pumping of fluid out of conduit close to sea level, or other methods. Flow within conduit can become self-propelled if natural gas is present and creates an “air lift” effect as the natural gas expands at lower pressures closer towards sea level.
US08801933B2 Membrane distillation modules using oleophobically and antimicrobially treated microporous membranes
The present invention provides a system for liquid distillation which includes a vapor permeable-liquid impermeable microporous membrane having structures defining a plurality of pores, an oleophobic material that is applied to the structures of the membrane so as to leave the plurality of pores open, a means for supplying non-distilled liquid to the first side of the membrane, and a means for collecting distilled liquid from a second side of the membrane. In a further example, the present invention provides a method for the distillation of liquids.
US08801932B2 Sub-critical partial oxidation for treatment of nitration wastes
A process for treating wastewater containing nitro-hydroxy-aromatic compounds using oxidative sub-critical conditions. The wastewater to be treated is adjusted to contain excess hydroxide equivalent to greater than three moles of free hydroxide per mole of total nitro-hydroxy-aromatic compounds, and a sub-stoichiometric amount of an oxidant is supplied to the wastewater. The nitro-hydroxy-aromatic compounds may include nitro-phenol salts or nitro-cresol salts.
US08801928B2 Fuel supply device, particularly for an internal combustion engine
A fuel supply device (1), particularly for an internal combustion engine (6), is equipped with a particulate filter and a water trap. In order to improve the separation effect, while simultaneously reducing the separation material that is required, it is proposed to configure the water trap (5, 8, 30) as a separate component connected downstream of the fuel filer (4) and to provide it with a first separation stage made of coalescent material and a second separation stage made of hydrophobic material, and to dispose the separation stages such that between them the fuel is diverted.
US08801924B2 Chromatography methods
This application discloses, in part, 1) a stationary phase column and compression designs for preparative chromatography, 2) a method of improving performance of silica gel chromatography by controlling the hydration of silica gel and acidifying the mobile phase, and 3) a method of extending the life of a silica gel column packing by cleaning or regenerating the silica gel stationary phase.
US08801917B2 Electrochemical potentiometric sensing without reference electrode
The invention relates to a method of determining a charged particle concentration in an analyte (100), the method comprising steps of: i) determining at least two measurement points of a surface-potential versus interface-temperature curve (c1, c2, c3, c4), wherein the interface temperature is obtained from a temperature difference between a first interface between a first ion-sensitive dielectric (Fsd) and the analyte (100) and a second interface between a second ion-sensitive dielectric (Ssd) and the analyte (100), and wherein the surface-potential is obtained from a potential difference between a first electrode (Fe) and a second electrode (Se) onto which said first ion-sensitive dielectric (Fsd) and said second ion-sensitive dielectric (Ssd) are respectively provided, And ii) calculating the charged particle concentration from locations of the at least two measurement points of said curve (c1, c2, c3, c4). This method, which still is a potentiometric electrochemical measurement, exploits the temperature dependency of a surface-potential of an ion-sensitive dielectric in an analyte. The invention further provides an electrochemical sensor for determining a charged particle concentration in an analyte. The invention also provides various sensors which can be used to determine the charged particle concentration, i.e. EGFET's and EIS capacitors.
US08801916B2 Recovery method of nickel from spent electroless nickel plating solutions by electrolysis
A recovery method of nickel according to the present invention comprises pretreatment step to prepare a solution for electrolysis by adding hexanesulfonate salt to a treatment solution including nickel, and nickel recovery step to recover nickel in a metal form by electrolysis of the above solution for electrolysis. The present invention can produce nickel in high purity with simple process with low cost, and can recover and reproduce nickel in a metal form with at least 99.5% of high purity and at least 90% of recovery rate.
US08801911B2 Device and method of manipulating particles
Provided is a device and method of manipulating particles. The device includes: a channel for accommodating an electrolyte solution including particles to be manipulated; an anode and cathode for imposing a direct current (DC) electric field on the channel; metal strip(s) attached to an inner wall of the channel and resulting in induced-charge electroosmosis near a surface of the channel; a DC power supply unit for supplying a DC voltage to the anode and the cathode of the channel; control electrodes on both sides of the metal strip(s) to locally tune the induced-charge electroosmosis on the metal strip(s) regardless of the global electric field across the channel; and a DC power supply unit for supplying a DC voltage to the control electrodes.
US08801907B2 Electrochemical cell
The present invention relates to electrochemical cells including a first working electrode 32, a first counter electrode 34, a second working electrode 36, and a second counter electrode 38, wherein the electrodes are spaced such that reaction products from the first counter electrode 34 arrive at the first working electrode 32, and reaction products from the first and second counter electrodes 34, 38 do not reach the second working electrode 36. Also provided is a method of using such electrochemical cells for determining the concentration of a reduced or oxidized form of a redox species with greater accuracy than can be obtained using an electrochemical cell having a single working and counter electrode.
US08801904B2 Chain drag system for treatment of carbaneous waste feedstock and method for the use thereof
A drag chain carbonizer is provided with a system and methods for anaerobic thermal transformation processing to convert waste into various solid carbonized products and varied further co-products. The drag-chain carbonizer includes an adjustable bed depth mechanism, a heating mechanism, a pressure management mechanism, and a chain tensioning mechanism containing at least one position sensor for communication of an actuator position to at least one programmable logic controller (PLC). Carbonaceous waste is transformed into useful co-products that can be re-introduced into the stream of commerce at various economically advantageous points. Depending upon the input materials and the parameters selected to process the waste, including real time economic and other market parameters, the system adjusts co-products output to reflect changing market conditions.
US08801903B2 Industrial fabric for producing tissue and towel products, and method of making thereof
A nonwoven fabric includes a plurality of through voids, where each of the voids has a first opening associated with a top surface of the fabric and a first raised edge circumferentially adjacent to the first opening. The voids may each further include a second opening associated with a bottom surface of the fabric and a second raised edge circumferentially adjacent to the second opening, such that the first opening may have a surface area that is larger than or the same as the second opening.
US08801901B1 Sized fluff pulp
Embodiments of sized fluff pulp, or fluff pulp treated with a sizing agent, have desirable characteristics for one or more intended applications. The sized fluff pulp can be debonded or non-debonded. In several examples, the one or more desirable characteristics includes a reduction in its absorption characteristics (e.g., the pulp is less hydrophilic). Some characteristics improved by the sized fluff pulp include, but are not limited to, soak and drip capacity and wicking rate. In several examples, the sized fluff pulp are less hydrophilic but retain or exhibit other desirable characteristics for producing non-wovens, including low fiberization energy and fiberized knot percentage.
US08801900B2 Starch composition for use in paper manufacture
The starch composition comprises a cationic, cross-linked starch that is partly swollen and partly gelatinized. It has a gelatinization coefficient gT smaller than 0.7 with T the jet cooking temperature. The starch composition suitably comprises a wheat starch or a blend of a wheat starch and another starch, for instance a root or tuber starch.
US08801898B2 Method and arrangement for adding treatment liquors to cellulose raw material in a continuous process using down flow vessels
The method and arrangement is for adding treatment liquor to comminuted cellulose material, preferably wood chips, during the manufacture of chemical pulp in a continuous process. The process uses a down-flow vessel where chips are descending down the vessel in a plug-flow and where treated chips are continuously fed out at the bottom of the vessel. By arranging more than two parallel pipes offset from the center of the vessel a better distribution of treatment liquor is obtained. Any disturbance of the chip plug flow descending down the vessel is reduced to a minimum.
US08801893B2 Method of cooling a wafer support at a uniform temperature in a capacitively coupled plasma reactor
A method of transferring heat from or to a workpiece support in an RF coupled plasma reactor includes placing coolant in an internal flow channel that is located inside the workpiece support and transferring heat from or to the coolant by circulating the coolant through a refrigeration loop in which the internal flow channel of the workpiece support constitutes an evaporator of the refrigeration loop. The method further includes maintaining thermal conditions of the coolant inside the evaporator within a range in which heat exchange between the workpiece support and the coolant is primarily or exclusively through the latent heat of vaporization of the coolant.
US08801885B2 Method for making a structural part of a composite material having a calibrated thickness and structural part thus obtained
The disclosed embodiments offer a solution for controlling the thickness of a finished structural composite part when precise tolerances must be complied with for the quality of the assembly and in order to ease the assembly operations of this part. In order to implement the method according to the disclosed embodiments, an additional layer of plies made out of a non-structural composite material, called calibrating plies, is applied onto the structural plies of the structural part, at least in an area where the thickness must be maintained within close tolerances and, after the composite material has been cured, the calibrating plies are machined in order to obtain the thickness required for the finished part. The thickness of the calibrating plies applied is determined according to the possible thicknesses of structural plies, taking into account the manufacturing spreads so that the machining operation for the calibrating plies does not affect the structural plies.
US08801880B2 Formation of a fabric seam by ultrasonic gap welding of a flat woven fabric
The invention relates to ultrasonic gap welding of flat woven fabrics. Specifically, the invention relates to a method of ultrasonic welding the seam termination yarn ends of a fabric using a controlled gap. A mechanical stop may be employed to control the distance or gap between the horn and anvil to a predetermined level based on the depth of welding and amount of weld energy. By adding another degree of control, the ultrasonic gap welding technique of the present invention is able to achieve fabric seams that are stronger than conventional seams, and even those enhanced with gluing, and is conducive to formation of fabric seams by spot welding or along the termination yarn ends of the fabric.
US08801879B2 Method for manufacturing multilayer film
A process for production of a multilayer film that comprises a step in which an adhesive layer formed on a temporary base is situated along the lengthwise direction of the temporary base at a prescribed spacing and cut in such a manner that the plurality of sections which are to serve as adhesive films are partitioned from the other sections, and a step in which the adhesive films on the temporary base are moved onto a support film at a prescribed spacing along the lengthwise direction of the support film. The spacing between the adjacent adhesive films on the temporary base is different from the spacing between the adjacent adhesive films on the support film.
US08801871B2 Zr-/Ti-containing phosphating solution for passivation of metal composite surfaces
The present invention relates to an aqueous composition and to a method for the anticorrosion conversion treatment of metallic surfaces, particularly metallic materials which are assembled into composite structures, comprising steel or galvanized or alloy-galvanized steel and any combinations of these materials, the composite structure being composed at least in part of aluminum or the alloys thereof. The aqueous composition according to the invention is based on a phosphating solution and contains, in addition to water-soluble compounds of zirconium and titanium, a quantity of free fluoride in a ratio that both permits phosphating of the steel and galvanized and/or alloy-galvanized steel surfaces and determines low pickling rates with regard to the aluminum substrate with simultaneous passivation of the aluminum. The metallic materials, components and composite structures conversion treated in accordance with the underlying invention are used in automotive body construction, in shipbuilding, in construction and for the production of white goods.
US08801868B2 Dishwasher
A dishwasher includes a tub at least partially defining a wash chamber and at least one dish rack located within the wash chamber. The dishwasher also has at least one sprayer located in the wash chamber and at least one nozzle located in the wash chamber and configured to provide a spray of liquid into the dish rack. A diverter valve controls the supply of liquid from a liquid supply to the at least one nozzle.
US08801857B2 Self-centering susceptor ring assembly
A self-centering susceptor ring assembly is provided. The susceptor ring assembly includes a susceptor ring support member and a susceptor ring supported on the susceptor ring support member. The susceptor ring support member includes at least three pins extending upwardly relative to the lower inner surface of the reaction chamber. The susceptor ring includes at least three detents formed in a bottom surface to receive the pins from the susceptor ring support member. The detents are configured to allow the pins to slide therewithin while the susceptor ring thermally expands and contracts, wherein the detents are sized and shaped such that as the susceptor ring thermally expands and contracts the gap between the susceptor ring and the susceptor located within the aperture of the susceptor ring remains substantially uniform about the entire circumference of the susceptor, and thereby maintains the same center axis.
US08801851B2 Foamed concrete
A foamed concrete having a density from 100 to 800 kg/m3 including by mass relative to the total mass of the concrete: a cement; water; from 0.01 to 5% of a water-reducing agent, plasticizer or superplasticizer; from 0.45 to 5% of a foaming agent relative to the amount of water; from 0.01 to 5% of a water-soluble calcium salt; inorganic particles from 0.1 to 300 μm in size; the ratio of foaming agent to calcium salt being from 0.3 to 0.8; excluding foamed concretes including 10% or more by mass of slag.
US08801846B2 Self-neutralising type of calcium hydroxide preparation for use in dentistry
The present invention relates to a self-neutralising type of calcium hydroxide (Ca(OH)2) preparation for use in dentistry. More specifically, it relates to a self-neutralising type of calcium hydroxide preparation which is formulated in such a way that it can be used in dentistry by being mixed, in a cement clinker, with an active siliceous substance, bismuth oxide (Bi2O5), silica, sulphur trioxide and aluminum oxide/ferric oxide and the like. One aspect of the present invention provides a self-neutralising type of calcium hydroxide preparation comprising an active siliceous substance and bismuth oxide, and this self-neutralising type of calcium hydroxide preparation is characterized in that it comprises silica, sulphur trioxide and aluminum oxide/ferric oxide.
US08801839B2 Method and device for drying of a gas
Device for drying gas includes a dryer with a vessel which has at least three compartments at a first axial end of a rotor rotatably disposed in the vessel, the rotor arranged for conduction of at least three gas flows, including a main flow, a regeneration flow and a cooling flow, respectively. A first compartment of the vessel has an outlet for said main flow, a second compartment has an inlet for the cooling flow and a third compartment has an inlet for the regeneration flow. The vessel at the second axial end of the rotor has a first compartment which includes an inlet for the main flow and a second compartment with an outlet for the cooling flow and the regeneration flow.
US08801838B2 Advanced laminar flow water condensation technology for ultrafine particles
This technology relates to the enlargement by water condensation in a laminar flow of airborne particles with diameters of the order of a few nanometers to hundreds of nanometers to form droplets with diameters of the order of several micrometers. The technology presents several advanced designs, including the use of double-stage condensers. It has application to measuring the number concentration of particles suspended in air or other gas, to collecting these particles, or to focusing these particles.
US08801837B2 De-aerator dampener separator and related methods
A de-aerator dampener separator includes a separator with a vortex chamber having at least one vortex chamber entry port. The de-aerator dampener separator further includes a column assembly with a column entry port in fluid communication with the vortex chamber exit port. The de-aerator dampener separator further includes a baffle within the column assembly.
US08801835B1 Reducing loss rates of glycerol associated with dehydration of carbon dioxide
In some implementations, a method for dehydrating carbon dioxide includes identifying a stream including at least carbon dioxide and water. At least a portion of the stream is dehydrated using an initial lean sorbent including glycerol and a polyhydric alcohol to generate dry carbon dioxide stream and rich sorbent including water. The polyhydric alcohol reduces an amount of glycerol lost to the dry carbon dioxide stream during dehydration. This process may result in the beneficial reduction in the amount of glycerol that leaves the system with the dry carbon dioxide. The dry carbon dioxide and the rich sorbent are separated. The glycerol is recycled by dehydrating the rich sorbent to produce recycled lean sorbent.
US08801833B2 De-powdering plant for a scrap shredding machine and relative method
A de-powdering plant is able to be used downstream of a shredding machine and comprises a first section for processing a primary stream of powder and air arriving from a first exit line from the shredding machine, which comprises a unit for damping powders using humidity connected to an air intake downstream of the shredding machine. The first processing section also comprises a processing unit using active carbons filtration, downstream of the unit for damping powders using humidity, suitable for the adsorption of the volatile organic substances present in a stream of air exiting from the unit for damping powders using humidity. The plant comprises heating means to heat, directly or indirectly, the stream of air saturated with humidity exiting from the unit for damping powders using humidity, before it enters into the processing unit using active carbons filtration.
US08801825B2 Systems and methods for air intake filter assemblies
Combustion turbine air intake filter assemblies, their components, and methods of use are disclosed. In certain embodiments, the assemblies may be useful, inter alia, for extending high efficiency filter life, reducing turbine downtime for filter assembly changeouts, or adjusting filter assemblies to address changing local conditions after the assemblies have been put into service.
US08801823B2 Device, method, and system to separate liquid and particulate matter from the airstream of a centrifugal fan
A system for separating contaminants from an airstream, including a centrifugal fan and housing; a contaminant containment vessel mounted to an outer surface of the housing; and a diverter in the airstream downstream of the fan and within the housing, the diverter being configured to separate a portion of the airstream from a remainder of the airstream, accelerate the portion of the airstream towards the containment vessel, and thereafter guide the portion of the airstream towards the remainder of the airstream. The diverter preferably does not negatively impact the rated performance of the fan, such that a performance of the system is not measurably different than the rated performance of the fan and housing combination. The diverter may accelerate contaminants entrained in the airstream toward the containment vessel, thereby separating the contaminants from the airstream.
US08801822B2 Exhaust gas treatment system for engine
An exhaust gas aftertreatment system for an engine can perform manual regeneration control for regenerating a particulate removal filter by increasing the engine rotation speed. The system can suppress the engine rotation speed increase while maintaining the exhaust gas temperature required to regenerate the particulate removal filter. The system can set the target engine rotation speed to a first set value when a regeneration instruction signal from a manual regeneration switch is received. When, although the engine rotation speed falls within a predetermined engine rotation speed range including the first set value that is the target engine rotation speed for a predetermined time period, the exhaust gas temperature does not reach the filter's regeneration temperature within the predetermined time period, the target engine rotation speed is repeatedly reset by being increased from the first set value by a predetermined rotation speed.
US08801819B2 Air cleaner assembly
In at least some embodiments, the present invention relates to an air cleaner having a housing portion, and a low profile rain cover having an opening on an underside of the cover to allow unfiltered air to enter into the air cleaner. Also, in at least some embodiments, the present invention relates to an air cleaner including a housing and an additional component by which the air cleaner is capable of being directly coupled to a carburetor inlet. In some such embodiments, one or more protrusions can be provided within a channel formed by the housing/additional component to influence air flow. Further, in at least some embodiments, the present invention relates to an air cleaner having a shaped wall formed on a housing portion, where the shaped wall includes both an interior surface and an exterior surface by which air flowing within the air cleaner is imparted with helical motion.
US08801817B2 Surface-coated cutting tool and manufacturing method thereof
A surface-coated cutting tool according to the present invention includes a base material and a coating film formed on the base material. The coating film includes at least one TiCN layer. The TiCN layer has a columnar crystal region. The columnar crystal region is characterized by having a composition of TiCxNy (in which 0.65≦x/(x+y)≦0.90) and having a (422) plane having a plane spacing of 0.8765 Å to 0.8790 Å.
US08801810B1 Conducting formation cycles
Provided are methods of preparing a lithium ion cell including forming the cell by charging the lithium ion cell to at least about 5% or, more specifically, to at least about 20% of the theoretical capacity of the negative electrode electrochemically active material, holding the lithium ion cell in a charged state for at least about 0.5 hours, and discharging the lithium ion cell. Holding the lithium ion cell in a partially charged state is believed to significantly improve its Coulombic efficiency during subsequent cycling.
US08801809B2 Method of producing an aluminum slug anode
An aluminum slug anode usable in capacitors is produced from multiple-stacked layers of aluminum foils. The foils are stacked (possibly after cutting them to have an area similar to the area desired for the anode), hot-pressed, sintered, and anodized to generate the anode. A contact in electrical communication with the foils is formed, as by welding a contact across at least some of the foils. A capacitor casing be formed by situating the anode within a casing which serves as a cathode, with the anode being wrapped in a dielectric such as separator paper.
US08801806B2 Treatment of non-trans fats and fatty acids with a chelating agent
The invention relates to methods and compositions for treating non-trans fats, fatty acids and sunscreen stains with a chelating agent. The invention also relates to methods for reducing the frequency of laundry fires with a chelating agent.
US08801805B2 Agent comprising hydrogen peroxide having improved viscosity adjustment
An agent includes in a cosmetically suitable carrier at least hydrogen peroxide, at least one homo- or copolymer of acrylic acid and/or methacrylic acid and at least one polyurethane, wherein the polyurethane is a polycondensation product of polyethylene glycol(s), diisocyanate(s) and optionally ethoxylated fatty alcohol(s).
US08801804B2 Non-metal tanning process
Tanned leather, skin or pelt is produced by non-metal tanning, comprising the step of tanning a bated hide, skin or belt with a tanning agent (A) of at least a mixture of compounds of formula (I) and formula (II), wherein Hal signifies fluorine or chlorine, R1 signifies hydrogen, C1-8-alkyl or an alkyleneoxy radical of formula (III), —(—C2-3 alkylene-O—)q—H (III); R2 signifies a) phenyl, mono- or di-substituted with SO3M or COOM and optionally substituted also with hydroxyl, C1-4-alkyl C1-4-alkoxy; b) naphthyl, mono- or di- or tri-substituted with SO3M and optionally substituted also with hydroxyl; c) C1-8-alkylene, substituted with (SO3M) or (COOM); d) aradical of formula (IV), —(—C2-3 alkylene-O—)p—Y (IV) or e) a radical of formula (IVa) —(C2-3 alkylene-O)p—C2-3 alkylene-SO2CH2CH2O—Y (IVa), M signifies 1 or 2, p signifies 0 or 1, Y signifies hydrogen or —SO3M, q signifies 1 to 10, M signifies hydrogen, an alkali metal cation or an ammonium cation being aprotonated tertiary amine or a quaternary ammonium cation, R3 signifies hydrogen or chlorine. In a tanning bath having a pH of from 6 to 10 at the beginning of tanning step.
US08801794B2 Flanged interbody fusion device with fastener insert and retaining ring
Methods and devices are disclosed for treating the vertebral column. An integrated fixation plate and spacer having a retaining structure within the screw holes of the fixation plate to resist backout of screws attaching the fixation plate to the bone is provided. A movable joint may be provided between the fixation plate and spacer. In some embodiments, a screw hole insert is also provided to resist shear forces acting between the screw and fixation plate. In some embodiments, an integrated fixation plate and spacer system is provided, comprising two or more integrated fixation plate and spacer implants, wherein the fixation plates of each implant has a complementary configuration to allow attachment of the implants at adjacent intervertebral spaces. Alternative fixation systems are also contemplated.
US08801790B2 Intervertebral disc augmentation and rehydration with superabsorbent polymers
The embodiments provide a method for treating an intervertebral disc having a nucleus pulposus and an annulus fibrosis, using one or more superabsorbent polymers. Additionally, the embodiments provide a method for bulking up an intervertebral disc having a nucleus pulposus and an annulus fibrosis, using one or more superabsorbent polymers. The methods comprise introducing an amount of the superabsorbent polymers into the intervertebral disc space without removing nucleus pulposus or annulus fibrosis material.
US08801789B2 Two-component artificial disc replacements
Artificial disc replacements (ADRs) and total disc replacements (TDRs) are based upon two, directly articulating components, resulting in a restricted-motion system that better approximates more normal spinal flexion, extension, and lateral bending. Both components are preferably made of a hard material and are highly polished to reduce friction.
US08801787B2 Methods of distracting tissue layers of the human spine
Methods of separating and/or supporting layers of tissue in the human spine. Such methods generally comprise inserting at least a distal end portion of a guide member between layers of tissue in the human spine wherein the distal end portion defines a predetermined shape. A distraction device is advanced over at least the distal end portion of the guide member so that the distraction device substantially assumes the predetermined shape of the distal end portion of the guide member to form a support structure between the tissue layers that separates and/or supports the tissue layers.
US08801785B2 Articulating spinal implant
A spinal implant and method of implanting a spinal implant that has a spacer and a plate configured to be fastened to a plurality of vertebral bodies. The plate is coupled to the spacer, with the spacer and the plate being angularly adjustable with respect to each other.
US08801784B2 Clamping assemblies for securing ligaments to a bone
An assembly for securing a plurality of ligaments to a bone includes a first portion exhibited by such as a ring shaped clamp with a tab and slot or a split stem incorporating a plurality of spaced apart ring shaped clamps compressively gripping about the ligaments. A second portion includes at least one of a screw or a ring extending portion engaging a ligament end loop or an undercut recess seating portion extending from an end of a body also incorporating the first portion, and such that the second portion extends from an end of the ligaments and mounts to the bone. The ligaments may further include first and second end-to-end attached sections, between which are configured angled and opposing/aligning incisions.
US08801779B2 Prosthetic valve for transluminal delivery
A prosthetic valve assembly for use in replacing a deficient native valve comprises a replacement valve supported on an expandable valve support. If desired, one or more anchor may be used. The valve support, which entirely supports the valve annulus, valve leaflets, and valve commissure points, is configured to be collapsible for transluminal delivery and expandable to contact the anatomical annulus of the native valve when the assembly is properly positioned. The anchor engages the lumen wall when expanded and prevents substantial migration of the valve assembly when positioned in place. The prosthetic valve assembly is compressible about a catheter, and restrained from expanding by an outer sheath. The catheter may be inserted inside a lumen within the body, such as the femoral artery, and delivered to a desired location, such as the heart. When the outer sheath is retracted, the prosthetic valve assembly expands to an expanded position such that the valve and valve support expand within the deficient native valve, and the anchor engages the lumen wall.
US08801778B2 Implant with a base body of a biocorrodible alloy
An implant having a base body, comprised either entirely or in part of a biocorrodible metallic material wherein at least the parts of the base body having the biocorrodible metallic material are at least partially covered with a coating of a crosslinked CFx layer that is nonpolymerized and has an F/C ratio in the range of 0.5 to 1.5.
US08801777B2 Intravascular device with netting system
An intravascular device for keeping open a previously constricted site within a vessel and for minimizing tissue debris at such a site from closing off the vessel is provided. The device includes an expandable substantially tubular body having a distal end and a proximal end. The device also includes a flexible netting system that is circumferentially disposed about the body, and extends beyond at least one of the distal end or proximal end. The netting system can expand along with the body to minimize release of tissues debris at the site from closing the lumen of the vessel. The netting system can include a plurality of pores to permit communication between fluid flow within the vessel and the vessel wall, and at least one pharmacotherapeutic agent for the treatment or prevention of certain conditions. A method for placing the device at a site of interest is also provided.
US08801775B2 Helical stent with opposing and/or alternating pitch angles
Waveforms for forming helical stents with opposing and/or alternating pitch angles along their lengths are disclosed. A wire is bent to form a waveform having a series of sinusoidal segments between a first end and a second end thereof. Each sinusoidal segment is longitudinally offset from its adjacent segment(s). Each waveform includes at least one sinusoidal segment having a first portion in which the amplitude between consecutive turns of the wire gradually increases and a longitudinally offset second portion in which the amplitude between consecutive turns of the wire gradually decreases. The waveform is wrapped from one end to the other about a mandrel to form the stent and depending on the arrangement of sinusoidal segments along the waveform may have opposing and/or alternating pitch angles along a section or an entire length of the stent.
US08801772B2 Stent to be used in tubular organ in vivo
Provided is a stent to be inserted into an in vivo organ having a tubular structure that allows a degree of freedom in design and excellent mechanical flexibility. A cylinder-shaped stent is inserted to be placed and used in the inner cavity of an in vivo tubular organ, wherein: the wall of the stent has a planar mesh pattern filled with a plurality of closed cells being adjacent to each other and having congruent shapes; the closed cells have point-symmetric parallel hexagonal shapes; all closed cells circumferentially adjacent to each other are congruent and similar in shape; two closed cells adjacent to each other sharing different sides form a substantially V-shaped member; and the vertex of each folded part in the substantially V-shaped member points to the circumferential direction.
US08801763B2 System for protection of soft tissues against a teeth whitening substance
The appliance includes a brushhead having conductive fiber bristles by which a potential is applied to electrochemically activate a teeth whitening substance, such as peroxide, in the vicinity of the teeth. An impedance appliance system (62) or an optical appliance system (27) provides information concerning whether the conductive fiber bristles are adjacent a tooth surface or gum region. The impedance system uses an electrical signal through the fiber to determine the impedance of a circuit which includes the tooth or gum surface, the impedance being different, depending on whether a tooth or gum surface is in the circuit. The optical system generates a light beam which is directed to the mouth surface through a conductive fiber, the color of the returning light indicating whether the surface is a tooth or gum region. If a tooth is determined, the teeth whitening substance is activated at that bristle, while if gum tissue is determined, the teeth whitening substance is not activated at that bristle.
US08801762B2 Bone screw and method for manufacturing the same
A faceted bone screw and a method for manufacturing the same includes a screw thread configuration having facets that are substantially transverse to the thread. The facets are generally made up of a plurality of peaks and valleys which vary the depth of the thread and are disposed in one or more locations throughout the threaded portion of the bone screw. The facets operate to reduce the torque required to drive the bone screw into bone, while at the same time operate to assist in anchoring the bone screw within the bone once inserted therein, and thereby reduce the possibility for the screw backing out after insertion.
US08801760B2 Growth control device
A growth control device includes a bone plate having a stepped profile defined by a first level, a second level and an intermediate ramp connecting the first and second levels. The first level includes a first threaded hole for receiving a first bone fastener and the second level includes a second threaded hole for receiving a second bone fastener. The bone plate includes a proximal pair of side female notches, a distal pair of side female notches, a proximal guide hole and a distal guide hole.
US08801758B2 Insertion instrument for intervertebral implants
An insertion tool for positioning intervertebral spacers into disc spaces. The insertion tool has a proximal end and a distal end, a T-handle secured to the proximal end and a pair of alignment rails extending to the distal end. The insertion tool includes a handle secured to the proximal end of the guide rails, and a shaft that extends through the handle, whereby the shaft has a threaded portion that extends to the T-handle. The insertion tool also includes a blocker that is secured to the distal end of the shaft. The blocker includes stop arms that guide the blocker through the guide rails and toward the distal end of the shaft. The blocker may be provided in a plurality of different sizes corresponding to the sizes of the implants to be inserted into a disc space. A lock is provided for locking the implant to the shaft.
US08801757B2 Spinal stabilization systems and methods of use
Devices and methods are adapted to permit fixation and stabilization of the bony elements of the skeleton. The devices permit adjustment and maintenance of the spatial relationship between neighboring bones. The motion between adjacent skeletal segments may be maintained, limited or completely eliminated.
US08801756B2 Polyaxial orthopedic fastening apparatus
An orthopedic fastener is designed to attach an implant to bone in such a manner that, until the fastener is tightened, the implant may be rotationally adjusted against the bone. The implant may have a semispherical bone apposition surface that permits polyaxial rotation of the implant against the bone. The orthopedic fastener has an interpositional member and a compression member. The interpositional member may be a split ring with a conical exterior surface that mates with a conical surface of the implant. The compressing member has a threaded bore that engages a proximal end of a fixation member implanted in the bone such that, in response to rotation of the compression member, the interpositional member is sandwiched securely between the implant and the compression member. The conical surface of the implant compresses the interpositional member about a semispherical surface of the compression member, thereby restricting rotation of the implant.
US08801754B2 Tissue anchor system
A suburethral sling system including a suburethral sling body having first and second ends; a tissue anchor connected approximate to each of the first and second sling ends, the tissue anchors having barbs for retaining the anchors in soft tissue; and an anchor delivery device having a hand-grip and an anchor stay adapted to reversibly mate with the tissue anchors.
US08801746B1 System and method for delivering a left atrial appendage containment device
A device for containing emboli within a left atrial appendage of a patient includes a frame that is expandable from a reduced cross section to an enlarged cross section and a slider assembly. There is provided in accordance with various embodiments of the present invention methods of preventing retention anchors from projecting outside of the native diameter of the frame, thus facilitating recapture of the device.
US08801744B2 Expandable introducer sheath to preserve guidewire access
An introducer sheath. The introducer sheath includes a tubular body. The tubular body extends from a distal end toward a proximal end. The tubular body includes a lumen. The lumen is defined at least partially by a wall. The tubular body includes a secondary channel. The secondary channel is disposed within the wall. The secondary channel is configured to receive a guidewire.
US08801742B2 Needle assembly and blade assembly for biopsy device
A biopsy device may comprise a probe assembly that has a needle assembly extending distally from the probe assembly. The needle assembly has a needle portion and blade assembly. The blade assembly comprises a blade and a multi-member coupling assembly. The multi-member coupling assembly is configured to couple to the blade and to the needle portion to attach the blade to the needle portion. In one configuration the multi-member coupling assembly comprises two coupling members configure to couple to the blade. The blade may be a flat blade that has a retention channel formed therein, wherein the two coupling members may couple to the blade at the retention channel. The needle portion may comprise a needle and a cutter receiving tube. The needle may be an ovular cross-sectioned tube having a cut-out portion into which a circular cross-sectioned cutter receiving tube may be inserted and coupled thereto.
US08801739B2 Devices and methods for arched roof cutters
Disclosed herein are tissue-removal devices and methods for treating spinal diseases using such devices. The tissue-removal devices may comprise a cable and/or extendable elements with a retracted and a deployed configuration. The cable and/or extendable elements may be distally supported and restrained by a support element such that the support element may be pushed transversely away when the extendable element is distally extended into its deployed configuration. An annular cutting element may be provided about the distal end of the extendable element or the support element. Various configurations of the extendable and support elements are described herein, as well as methods of using tissue-removal devices with extendable and support elements coupled by an annular cutting element for treating spinal diseases.
US08801724B2 Device for placing or removing joints or joint sockets
A tool for placing or removing joint sockets of an artificial joint, especially a hip joint, and a tool for placing or removing an artificial joint, has a handle, a joint socket or joint receiver or holder, and a connecting element arranged between the handle and the joint socket or joint holder. The connecting element comprises an arcuate portion in its longitudinal direction. A system for placing and removing joint sockets or joints using such a tool includes a position-determining and navigation device.
US08801721B2 Apparatus and methods for inserting an implant
A system and method for inserting an implant into a cavity is disclosed, which may include advancing an implant insertion instrument toward a pair of adjacent bodies, the implant insertion instrument having two opposed ramps, wherein each ramp has a distal tip and wherein the longitudinal axes of the opposed ramps are separated by an initial angle; inserting the distal tips of the opposed ramps between the adjacent bodies, thereby creating an initial interbody cavity between the adjacent bodies; expanding the interbody cavity while maintaining the initial angle between the longitudinal axes of the opposed ramps; placing the implant in a final location between the adjacent bodies; transferring a compressive force urging the adjacent bodies together from the opposed ramps to the implant; and extracting the implant insertion instrument from the interbody cavity.
US08801720B2 Total joint arthroplasty system
A method and system for performing a total joint arthroplasty procedure on a patient's damaged bone region. A CT image or other suitable image is formed of the damaged bone surfaces, and location coordinate values (xn,yn,zn) are determined for a selected sequence of bone surface locations using the CT image data. A mathematical model z=f(x,y) of a surface that accurately matches the bone surface coordinates at the selected bone spice locations, or matches surface normal vector components at selected bone surface locations, is determined. The model provides a production file from which a cutting jig and an implant device (optional), each patient-specific and having controllable alignment, are fabricated for the damaged bone by automated processing. At this point, the patient is cut open (once), the cutting jig and a cutting instrument are used to remove a selected portion of the bone and to provide an exposed planar surface, the implant device is optionally secured to and aligned with the remainder of the bone, and the patient's incision is promptly repaired.
US08801715B2 Apparatus for preoperative planning of artificial knee joint replacement operation and jig for supporting operation
Methods and apparatuses for displaying images are provided which input two-dimensional tomographic images of the lower limb including the knee joint, display three-dimensional images of the femur and the tibia including the knee joint from the image input, determine an artificial joint to be replaced from the three-dimensional images of each knee joint of the femur and tibia, and determine various parameters used in an artificial knee joint replacement operation using an alignment rod in the marrow to be inserted into the femur based on the artificial joint and reference points of the knee joint determined when determining a femur side artificial joint.
US08801705B2 Electrosurgical method and apparatus for removing tissue within a bone body
A method for treating a bone body comprises inserting a probe having at least one active electrode into the target tissue and applying a voltage difference between an active electrode and return electrode to ablate the tissue. The method is particularly directed to removing tumors in a bone body and or removing cancellous bone in a bone body. The bone body may be a vertebral body. An apparatus includes a plurality of active electrodes and a distal section including two bends. The bends serve to prevent the active electrodes from impinging upon the shaft of an introducer needle. Also, a kit includes an electrosurgical probe, an electrosurgical generator, an introducer needle, and a fluid connector to connect the introducer needle to a fluid source such that liquid may be supplied to the target site during an application.
US08801704B2 Impedance computation for ablation therapy
This disclosure describes impedance computation techniques that may reduce the effect of crosstalk, thus generating more accurate impedance measurements. In particular, an ablation system models the electrical interaction among the active electrodes and a common return electrode using a star-configuration resistor model. The ablation system computes one or more parameters of the star-configuration resistor model and adjusts the therapy based on at least the computed parameters of the star-configuration resistor model.
US08801693B2 Bioimpedance-assisted placement of a medical device
A system and method for guiding a catheter or other medical device to a desired target destination within the vasculature of a patient via bioimpedance measurements is disclosed. The target destination in one embodiment includes placement of the catheter such that a distal tip thereof is disposed proximate the heart, e.g., the junction of the right atrium and superior vena cava. In one embodiment the method for guiding the catheter comprises introducing the catheter into a vessel of the patient, the catheter defining a lumen through which fluids can be infused into the vasculature of the patient. The catheter is advanced toward a target destination within the vasculature. A first impedance value based on intravascular detection of at least one electrical property related to a first tissue surface of the vessel is calculated to enable determination of the proximity of a distal end of the catheter to the target destination.
US08801692B2 Gradient coated stent and method of fabrication
The gradient coated stent 150 of the present invention provides a coated stent having a continuous coating 130 disposed on the stent elements. The continuous coating 130 includes a first coating component and a second coating component. The concentration of the first coating component varies continuously over at least part of the thickness of the continuous coating 130. The concentration of the second coating component can also vary over at least part of the thickness of the continuous coating 130. In one embodiment, the concentration of the first coating component decreases in the direction from the stent element towards the outer edge of the continuous coating 130 and the concentration of the second coating component increases in the direction from the stent element towards the outer edge of the continuous coating 130.
US08801688B2 Nutritive substance delivery container
The invention comprises a novel apparatus for delivering a nutritive substance comprising a container body having a base at one end thereof, an upper portion adapted for removable receipt of a closure, the upper portion defining an opening therein, and a chamber defined by the container body, the chamber being in fluid communication with the upper portion opening. A seal is bonded across the upper portion opening of the container and is adapted to provide an airtight seal across the opening. A closure is removably coupled to the container upper portion. A nutritive substance is coated onto an element selected from the group consisting of an inner surface of the container upper portion, the closure, an insert positioned above the seal, and combinations thereof. The seal prevents contact between the nutritive substance and the contents of the container until the seal is removed or pierced.
US08801686B2 Reduced-pressure, multi-orientation, liquid-collection canister
A liquid-collection canister includes a liquid collection chamber defined by at least one wall and a first and second gas-communication pathway formed within the at least one wall. A first aperture is positioned between the first gas-communication pathway and the liquid collection chamber to allow gaseous communication between the liquid collection chamber and the first gas-communication pathway. A second aperture is positioned between the second gas-communication pathway and the liquid collection chamber to allow gaseous communication between the liquid collection chamber and the second gas-communication pathway. A first and a second liquid-air separator are positioned over the first aperture and the second aperture, respectively, to substantially prevent liquid passing through the first and second apertures.
US08801684B2 Coupling part of a drainage tube unit
A coupling part of a drainage tube unit for aspirating body fluids by a suction pump includes a patient-side drainage attachment, a pump-side drainage orifice for connection to a drainage tube, and a drainage channel connecting the drainage attachment and the drainage orifice to each other. The coupling part also includes a pump-side first service orifice for connection to a service tube, a second service orifice ending in the interior of the coupling part, a service channel connecting these first and second service orifices, and a device which separates the service channel from the drainage channel. The device permits delivery of fluid from the service channel into the drainage channel and prevents delivery of particles and liquid from the drainage channel into the service channel. The device is arranged in the coupling part at a location that allows a flow through the drainage channel from the drainage attachment to the drainage orifice without passage through the device.
US08801683B2 Bowel management system
A bowel management system includes a waste collection catheter having at least two distinct sections. The first section is patient proximal when disposed in the patient's rectum and has durometer hardness in the range of about 50A to about 90A. The second catheter section is connected to the first section and has durometer hardness in the range of about 5A to about 49A. A selectively collapsible, substantially spherical retention balloon is attached coaxially and exterior of the first catheter section such that the proximal-most end of the retention balloon is coincident to the proximal-most end of the first section of the waste collection catheter, the substantially spherical retention balloon having an inflated size so as to be sufficiently large enough to retain the patient proximal end of the catheter in the patient's rectum without being so large as to trigger a defecatory response in the patient.
US08801682B2 Apparatus for separating tissue cells from a fluid
The invention relates to an apparatus for separating tissue cells from a fluid, with a collection container forming a collection space, which is connected, on one hand, with a negative pressure source and which is connected, on the other hand, with a supply line for the fluid-tissue cell mixture.It is provided that inside the collection space (18) a communicating tube (16) is arranged, which terminates at a distance from the bottom (17) of the collection container (14), wherein a connection is provided between the communicating tube (16) and the collection space (18) above a fluid-tissue cell mixture level (22) established in the collection container (14), and a suction element (20) which is connected with the negative pressure source (6) is arranged inside the communicating tube (16).
US08801674B2 Autoinjectors
An autoinjector includes front and rear separable housing parts 10, 12. These are connected by a rotary coupling action such as by bayonet coupling and the relative rotation action turns a needle shield 20 from a locked position in which it is both locked against longitudinal movement and acts as a shutter obscuring the contents of the syringe to an open position where the contents of the syringe are visible and the shield portion is freed for longitudinal movement. Connecting and securing the rear portion 12 on the front portion 11 therefore unlocks the needle shield 20 for operation. On completion of an injection, uncoupling of the front and rear portions returns the needle shield 20 to its locked position so the front portion may be disposed of safely.
US08801672B2 Pivotable needle protector
At the pivotable needle protector (1) according to the invention, the needle (2) is enveloped by a protective tube (3) with a slit on the side and pivotable around a hinge (5), the hinge (5) of the protective tube (3) is connected to an appendix (4) fixed on the part of the needle (2) toward the syringe, in the inside of the protective tube (3) there are valve elements (6) on both sides farthering from the slit (7), functioning as check valve regarding the movement of the needle (2). The solution is characterized by that, before the check valve at least one more valve is formed in the protective tube (3) in direct connection with the needle (2) when moving, preventing only the two-way movement of the needle (2) with the help of one or more flexible valve membranes (8) protruding from the wall of the protective tube (3).
US08801670B2 Apparatus and method for accessing a sinus cavity
A system for accessing a sinus cavity of a subject includes an access tool configured to penetrate into the sinus cavity from a location external the subject. The system further includes an access sheath having a distal tubular portion, a lumen extending through the access sheath and the distal tubular portion and dimensioned to receive the access tool, the distal tubular portion comprising one or more cutting surfaces disposed about an external surface thereof. The one or more cutting surfaces may include a plurality of longitudinally oriented grooves for flutes disposed about the periphery of the distal tubular member.
US08801667B2 Pump for powered irrigator for sinus cavity rinse
A powered irrigator for use in rinsing nasal cavities provides a main body having a handle and fluid reservoir detachably coupled to one another, an outlet nozzle extending from a top end of the handle, a pump mechanism operably coupled to a power source, and a switch operably coupled to the power source for turning the pump mechanism on and off, and when the switch turns on the pump mechanism, fluid flows from the fluid reservoir into a first fluid coupling between the reservoir and the pump mechanism and into a second fluid coupling between the pump mechanism to the outlet nozzle.
US08801666B2 Device for reducing pressure variations in an aspiration branch, and surgical system
The invention relates to a device for reducing pressure variations in a fluid flowing in an aspiration branch of a surgical system, which pressure variations are generated by a pump that delivers in a non-continuous manner in the active operating state, with a diffuser arrangement which is arranged, in the aspiration branch, upstream of the pump in the direction of flow of the fluid. The invention also relates to a surgical system, in particular an ophthalmic microsurgical system for lens surgery.
US08801663B2 Protective device for an injection needle
A protective device for an injection or infusion needle is provided comprising a needle hub at the proximal end of the needle, on whose shaft a protective member for the needle tip is displaceable, the protective member having an engaging section which engages with the needle shaft to prevent the protective member from being displaced beyond the needle tip, wherein the protective member is surrounded by a tube whose diameter is locally reduced or deformed such that the protective member is confined in the tube.
US08801662B2 Balloon catheter providing decreased irritation and improved drug release and drug penetration
A drug-delivering medical device for delivering a drug to a target site in a body lumen is disclosed. The drug-delivering medical device includes a balloon catheter and an inflatable balloon positioned on the balloon catheter. The inflatable balloon has a hydrophilic surface. One or more portions of the hydrophilic surface are coated with two or more nano-carriers. A nano-carrier of the two or more nano-carriers includes a drug surrounded by an encapsulating medium. As the drug is surrounded by the encapsulating medium, the surface of the nano-carrier is devoid of the drug. When the inflatable balloon is inflated upon coming in proximity to a target site in the body lumen, about 30% to 80% of the two or more nano-carriers are released from the hydrophilic surface within 15-90 seconds.
US08801658B2 Breastfeeding milk consumption measuring device
A device and method for measuring an amount of breast milk suckled during a breastfeeding session, the device including a mechanism for determining the change in volume of a breast during the breastfeeding session (before breastfeeding and after breastfeeding), and a calculation unit for calculating therefrom the quantity of milk suckled during the breastfeeding session.
US08801654B2 Method and device for irrigation of body cavities
A pressure and a vision regulation method and device for irrigation of a body cavity (1), in which an inflow liquid pump (2) pressurizes the irrigation liquid in a feed line (13) and an outflow device (3) or an external suction source (20) drains the irrigation liquid from the body cavity (1) through a tubing (16) into a waste container (17). A control unit (4) controls either the inflow liquid pump (2) only or both the inflow liquid pump (2) and the outflow device (3) depending on an inflow irrigation liquid pressure from a pressure sensor (5). The method and the device are combined with a method for detecting blood cells, red blood cells, haemoglobin and/or debris in liquid coming from a surgical site to provide an automatic control and rinsing system with clear vision in the viewing area of the operational site.
US08801651B2 Pressurized carbon dioxide bathing apparatus
Provided is a pressurized carbon dioxide bathing apparatus for causing even a small amount of carbon dioxide to be efficiently absorbed from skin of a living body with the structure of a cover suit simplified, and the pressurized carbon dioxide bathing apparatus is to bring carbon dioxide with a concentration of a predetermined value or more into contact with skin of the human body and thereby promote the blood circulation, and is characterized by being comprised of a carbon dioxide supply means 1 for supplying a mixed gas of carbon dioxide and water vapor, a compressed air supply means 2, a first cover suit 3A which is connected to the carbon dioxide supply means 1 via a connector 6, is filled with the mixed gas supplied from the carbon dioxide supply means 1, and forms an enclosed layer 4 to bring the mixed gas into direct contact with skin of the human body, and a second cover suit 3B which is connected to the compressed air supply means 2 via a connector 7 and forms an enclosed layer 5 filled with compressed air supplied from the compressed air supply means 2 outside the first cover suit 3A, where the carbon dioxide is brought into contact with skin of the human body with a predetermined pressure value or more by the compressed air.
US08801649B2 Glaucoma treatment device
Methods and devices are adapted for implanting into the eye. An incision is formed in the cornea of the eye and a shunt is inserted through the incision into the anterior chamber of the eye. The shunt includes a fluid passageway. The shunt is passed along a pathway from the anterior chamber through the scleral spur of the eye into the suprachoroidal space and positioned in a first position such that a first portion of the fluid passageway communicates with the anterior chamber and a second portion of the fluid passageway communicates with the suprachoroidal space to provide a fluid passageway between the suprachoroidal space and the anterior chamber.
US08801648B2 Ocular implant with anchor and methods thereof
Implants and methods for treating ocular disorders are disclosed. One implant has an inlet portion configured to extend through a portion of a tissue of an eye and an outlet portion configured to extend into and along a physiologic outflow pathway of the eye. The implant provides a flow path between an anterior chamber of the eye and the physiologic outflow pathway. One implant includes a body having adjacent regions of differing cross-sectional dimensions configured to anchor the implant and/or stabilize at least a portion of the flow path through the implant. One method involves inserting a fiber optic in an eye, locating a distal end of the fiber optic at a physiologic outflow pathway through which aqueous humor drains from an anterior chamber of the eye, and delivering a material comprising a therapeutic agent along the fiber optic and into the physiologic outflow pathway.
US08801647B2 Use of a gastrointestinal sleeve to treat bariatric surgery fistulas and leaks
Method for treating a Roux-en-Y patient having fistulas and leaks as a result of bariatric surgery. A gastrointestinal implant device is anchored in the esophagus and extends through a stomach pouch into an intestine anastomosed to the stomach pouch to prevent fistulas and other damaged tissue from making contact with food and fluids entering the esophagus. The gastrointestinal implant device includes an unsupported flexible sleeve and an anchor coupled to a proximal portion of the sleeve. The flexible sleeve is open at both ends, and adapted to extend below a jejunum. The anchor is adapted to be retained within the esophagus, preferably just above the gastroesophageal (GE) Junction. The anchor can include a stent such as a wave anchor and is collapsible for catheter-based delivery and removal.
US08801646B2 Access disconnection systems with arterial and venous line conductive pathway
An extracorporeal blood system includes: an extracorporeal blood machine; an arterial line extending from the extracorporeal blood machine; a venous line extending from the extracorporeal blood machine; and an access disconnection circuit for detecting a disconnection of at least one of the arterial or venous lines from a patient, the access disconnection circuit including (i) a signal generation source having first and second signal generation source electrical lines each in electrical communication with blood traveling through one of the arterial or venous lines, (ii) a conductive pathway electrically communicating blood traveling through the arterial line with blood traveling through the venous line, and (iii) a signal processing unit positioned and arranged to process a signal generated by the source to detect the disconnection of the at least one of the arterial and venous lines.
US08801641B2 Exoskeleton and method for controlling a swing leg of the exoskeleton
A lower extremity exoskeleton, configurable to be coupled to a person, includes two leg supports configurable to be coupled to the person's lower limbs, an exoskeleton trunk configurable to be coupled to the person's upper body, which is rotatably connectable to the thigh links of the leg supports allowing for the flexion and extension between the leg supports and the exoskeleton trunk, two hip actuators configured to create torques between the exoskeleton trunk and the leg supports, and at least one power unit capable of providing power to the hip actuators wherein the power unit is configured to cause the hip actuator of the leg support in the swing phase to create a torque profile such that force from the exoskeleton leg support onto the person's lower limb during at least a portion of the swing phase is in the direction of the person's lower limb swing velocity.
US08801637B2 Body movement detecting apparatus and body movement detecting method
There is provided a body movement detecting apparatus having a body movement data acquiring unit configured to detect a body movement of a user and acquire body movement data relating to the body movement and a computing unit configured to calculate consumed energy on the basis of the body movement data, including: a time data acquiring unit configured to acquire time data when the body movement data is acquired; a data accumulating unit being capable of accumulating the body movement data in correspondence with the time data; and a detection condition changing unit being capable of changing a detection condition for detecting the body movement on the basis of the body movement data and the time data accumulated in the data accumulating unit.
US08801635B2 Adjustable pneumatic supporting surface
An apparatus and method are adapted for characterizing human tissue type. A plurality of inflatable bladders enable the application of kinetic energy to the human tissue. Collected data responsive to the applied kinetic energy differentiates between different tissue types and patient loading. The data can be routed via a network to a remote location.
US08801633B2 High-modulus superelastic alloy wire for medical and dental purposes
A wire used in the medical field for guiding purposes, as well as in other fields, such as in the field of orthodontics for teeth aligning purposes. The wire, when prepared for use in such applications, exhibits an innovative blend of advantageous properties, including enhanced kink resistance over stainless steel wires and enhanced stiffness over Nitinol wires, which enhance its use as a medical guidewire or stylet, and further, as an arch wire in orthodontia applications.
US08801630B2 Method of taking out liquid present inside subject therefrom
A method is provided to collect liquid, such as pancreatic juice water, and saline, from a body cavity of a subject. In the method, a tool is inserted through the body cavity to reach a target site in the body cavity. A body position of the subject is adjusted such that the wall surface of the body cavity including the target site intersects with a direction of gravitational force and the liquid present in the body cavity gathers on the wall surface intersecting with the direction of gravitational force. A recess is formed to be concaved on the wall surface in the direction of the gravitational force by making the tool press the wall surface of the body cavity. Therefore, the liquid present or discharged in the body cavity is accumulated in the recess. The liquid accumulated in the recess is taken out of the body of the subject.
US08801628B2 Methods and systems for medical home testing
Methods and systems for medical home testing are described. In one embodiment, the device includes a case member, a plunger member, an accumulator member and a handle member. The case member has a first distal end portion and a first proximal end portion. The first distal end portion has a distal opening and the first proximal end portion has an aperture. The plunger member is sized and configured for sliding through the aperture. The plunger member has a second distal end portion configured to slide within the case member. The accumulator member is disposed in the case member adjacent the plunger member. The accumulator member is compressed by the case member and configured for sliding through the distal opening as the plunger slides through the aperture. The handle member is attached to the accumulator member and extends through the plunger member. Other methods and systems are also described.
US08801626B2 Flexible neural localization devices and methods
Methods for determining if a nerve is nearby a device. The neural stimulation tools described herein are configured to be flexible and low-profile, so that they can be used within body regions that may be tortuous or difficult to reach, such as within a compressed or partially occluded neural foramen. In most cases, these tools described herein are ribbon-shaped and adapted to be manipulated bimanually, applying force to the ends of the devices from separate locations outside of the patient's body. Thus, the distal end region of the device may be configured to couple to the proximal end of a guidewire. One or more surfaces of the devices may include an electrode or multi-polar network of electrodes configured to stimulate only nerves within a predetermined distance of a particular face of the device. Methods of using these devices are described.
US08801623B2 Sensor determining a physical or physiological parameter
A device and method determining or measuring a biological, physical or physiological parameter of an object includes a flexible carrier configured to be placed in a vicinity of the object; and at least one a sensor element attached to the flexible carrier and configured to determine at least one biological, physical or physiological parameter. In addition, a heating element is attached to the flexible carrier and configured to provide heat to the object; and a degradable adhesive is arranged on the flexible carrier adjacent to the heating element and configured to at least temporally affix the flexible carrier to the object.
US08801621B2 Method, system and program product for analyzing pulse wave data
A pulse wave data analyzing method includes successively detecting bottom and top peak values of pulse wave data along a time axis, calculating successive bottom-to-top amplitude values along the time axis, and comparing first and second peak-to-peak amplitude values occurring in succession along the time axis. If the ratio of the second peak-to-peak amplitude value to the first peak-to-peak amplitude value is smaller than a preset threshold, the bottom and top peak values related to the second peak-to-peak amplitude value are classified as temporarily erased data. The second peak-to-peak amplitude value is compared with a third peak-to-peak amplitude value occurring immediately thereafter and, if the ratio between the second and third peak-to-peak amplitude values is larger than the threshold, the temporarily erased data is restored. If the ratio between the second and third peak-to-peak amplitude values is not larger than the threshold, the temporarily erased data is completely erased.
US08801619B2 Photoplethysmography for determining ventilation weaning readiness
Embodiments of the present disclosure relate to a system and method for determining a likelihood of successful ventilator weaning for a patient undergoing mechanical or assisted ventilation. Specifically, embodiments provided herein include methods and systems for determining or predicting weaning readiness in a patient based on physiological parameters determined via photoplethysmography.
US08801616B2 Ultrasonic diagnostic apparatus and ultrasonic image processing method
Disclosed herein is an ultrasonic diagnostic apparatus and ultrasonic image processing method. The ultrasonic diagnostic apparatus includes an ultrasonic transmission unit; An ultrasonic probe emits; An ultrasonic reception unit; An image processing unit; A sound velocity determination unit; and A control unit. Accordingly, there is an advantage in that the actual sound velocity of a reflected wave is estimated, so that high-quality ultrasonic images can be provided, and the time required for the estimation of a sound velocity can be reduced.
US08801615B2 System and method for ultrasound therapy treatment
A system and method for treating tissue uses an ultrasound therapy system including an ultrasonic applicator having has at least one transducer element. Steering and focusing of ultrasound beams uses at least one variable focus lens, which may be a fluid focus lens, attached to each transducer element so that focus of the variable focus lens is controlled by a voltage signal. A treatment controller receives input from an imager and controls the voltage applied to the variable focus lens. The treatment controller controls the lens voltage signals, at least partially determined by the input from the imager, and directs an ultrasonic treatment beam emitted by the transducer element. Fine adjustment of the therapy beam is achieved to deliver therapy for various prostate sizes and shapes while avoiding damage to critical structures such as the rectal wall and nerve bundles.
US08801613B2 Calibration for multi-stage physiological monitors
A physiological monitor is provided for determining a physiological parameter of a medical patient with a multi-stage sensor assembly. The monitor includes a signal processor configured to receive a signal indicative of a physiological parameter of a medical patient from a multi-stage sensor assembly. The multi-stage sensor assembly is configured to be attached to the physiological monitor and the medical patient. The monitor of certain embodiments also includes an information element query module configured to obtain calibration information from an information element provided in a plurality of stages of the multi-stage sensor assembly. In some embodiments, the signal processor is configured to determine the physiological parameter of the medical patient based upon said signal and said calibration information.
US08801610B2 Signal processing for continuous analyte sensor
Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.
US08801608B2 Two-stage spinal access channel with psoas docking
A method for creating a sequence of access channels to provide access for performing surgery on a lumbar spine; through positioning a patient to facilitate surgical access to the lumbar spine; docking a retractor device against a proximal surface of the psoas muscle and maintaining the pre-psoas access channel with the retractor device docked at the proximal surface of the psoas muscle. Making a direct visual inspection of the psoas muscle before splitting the psoas muscle to create and maintain a psoas access channel that extends from the pre-psoas access channel to the spine. Holding open the psoas access channel with a pair of retractor blades. After completing a surgical process on the spine removing the pair of retractor blades from the psoas access channel.
US08801599B2 Bariatric device and method
A bariatric device and method of causing at least partial satiety in a patient, includes positioning a body in a recipient, the body having a wall defining a lumen, the wall configured to generally conform to the shape and size of at least the abdominal portion of the esophagus and the proximal cardiac portion of the stomach. Force is exerted with the wall on the proximal cardiac portion of the stomach in the absence of food thereby activating receptors located in the proximal cardiac portion of the stomach, thereby influencing a neurohormonal feedback mechanism of the patient to cause at least partial satiety by augmenting fullness caused by food and simulating fullness in the absence of food.
US08801595B2 Articles, devices, and methods for pelvic surgery
Described are implants, tools, and related methods, for use in pelvic surgery to treat conditions such as prolapse and incontinence, including one embodiment of a method that uses a transcoccyx tissue path; other embodiments that use particular implants with various features relating to, e.g., end portions; and other embodiments relating to particular tools.
US08801594B2 Fluid control system for inflatable sphincter prostheses
A fluid transfer system for an inflatable sphincter prosthesis is disclosed. The implantable inflatable sphincter prosthesis may include a fluid transfer system and at least one inflatable cuff for occluding a body channel. The fluid transfer system may include an inflate pump, a deflate pump, and three one-way valves.
US08801590B2 Catheter to assist the performance of a heart
In a catheter (2) to assist the performance of a heart (1) with at least one pump (7), the pump is formed as a rotary pump at the distal end of the catheter (2), the rotor (6) lying distally on the outer side being coupled via a magneto coupling with a drive wheel (21), formed as a hydraulically or pneumatically operated paddle wheel, arranged inside the catheter (2). The driving fluid is supplied to the paddle wheel via a lumen (22) of the catheter (2) and is carried off via a further lumen (23) of the catheter.
US08801589B2 Methods, apparatus, and systems for magnetic stimulation
A coil suitable for tissue stimulation and especially for transcranial magnetic stimulation (TMS) may be used in conjunction with a pulse generator to induce electric field in the brain with less attenuation in depth compared to existing TMS coils. In an example, a coil winding is formed in a solenoid configuration around the head. Various related features, methods, and embodiments are described.
US08801586B2 System and process for separating a material
Disclosed is a system to separate, enrich, and/or purify a cellular population from a biological tissue, such as a tissue sample. For example, an adipose tissue sample can be acquired and disrupted. The disrupted tissue sample can then be separated and purified. The separated components can include multipotent, pluripotent, or other cell populations.
US08801581B2 Treadmill foldable into a chair
A treadmill foldable into a chair includes a treadmill body having a base and a treadmill belt wound around the base, a stand having left and right symmetric support frames, and the bottom of the two support frames being pivotally coupled to the base by a pivot portion, and a meter installed at the top of the stand for adjusting and controlling an exercise status of the treadmill body, such that when the treadmill body is being used, the stand is erected at a front section of the base. The treadmill further includes a backrest installed between the two support frames, such that when the stand is folded towards the rear by using the pivot portion as an axial center, the stand is converted into a chair disposed on the base. The invention provides a two-in-one function and serves as a chair when not being used as a treadmill.
US08801580B1 Exercise methods and appatatus
An exercise apparatus links rotation of a crank to generally elliptical motion of a foot supporting member. A foot supporting linkage is movably connected between a rocker and a crank in such a manner that the foot supporting member moves through paths of motion which are fixed, adjustable or variable.
US08801575B1 Powered vehicle interlock system
A powered vehicular interlock system includes a powered vehicle with a propulsion means, a final drive means, a braking means, and a vehicle operator's chamber having a floor and a seat. The system includes an automatic transmission, a braking activation interface located close to the floor on the floor first side section, and a propulsion activation interface located close to the floor on a floor second side section. The system includes a propulsion deactivation interlock system having a braking activation sensor, a deactivation module, and a power supply. In a first position, the propulsion deactivation interlock system is adapted to allow the powered vehicle to be propelled. For operation, upon activation of the braking activation interface to a second position, the propulsion deactivation interlock system adapted to prohibit the powered vehicle from being propelled.
US08801574B2 Method and apparatus for controlling clutch deactivation in a multi-mode powertrain system
A powertrain system includes an internal combustion engine, a multi-mode transmission having a plurality of torque machines, and a driveline. A method for deactivating a torque transfer clutch of the multi-mode transmission includes imposing prioritized clutch torque constraints to an off-going clutch. The constraints include minimum and maximum long-term desired clutch torque constraints that are superseded by minimum and maximum soft clutch torque constraints that are superseded by minimum and maximum short-term desired clutch torque constraints that are superseded by minimum and maximum hard clutch torque constraints. The off-going clutch is controlled in response to the prioritized clutch torque constraints.
US08801570B2 Ignition control type auto lever device
An ignition control type auto lever device may disclose shift mode control signals for P(parking)-R(rear)-N(neutral)-D(drive) that are generated by movement of an auto lever according to a gate pattern, another mode control signal that is generated by movement of the auto lever to a section behind the D(drive), and electric signals generated by at least one or more different operations of the auto lever at a section positioned ahead of the P(parking) position that are sent to a PIC (Personal Identification Card) system.
US08801569B2 Methods and apparatus for flexure-based torque sensor in a bicycle
In exemplary implementations, a bicycle has “power pedaling”, in which a rider's pedaling efforts are augmented by an electric motor. The rider can control the motor simply by pedaling. It is desirable that the motor torque not exceed the rider torque; otherwise the motor overpowers the rider. A radial flexure is part of the drivetrain that transmits torque from the rider to the back wheel. One part of the flexure is connected to the back wheel casing; another part of the flexure is connected to the freewheel. If motor velocity exceeds rider velocity, this causes the flexure to elastically deform. Two sensors measure the deformation, which is equal to the difference between the angular displacements of the casing and freewheel, respectively. A PD controller seeks to make this difference equal to zero, by controlling voltage levels in the motor (and thus controlling the torque contributed by the motor).
US08801568B2 Control apparatus and control method for hybrid vehicle
Controlling a hybrid vehicle includes: reducing a rotation speed of a motor generator before a locking apparatus that locks the motor generator is switched from a disengaged condition to an engaged condition; starting to switch the locking apparatus to the engaged condition when the rotation speed decreases to a predetermined operation permission rotation speed; controlling the locking apparatus such that from the start of the switch to the engaged condition onward, the rotation speed decreases from the operation permission rotation speed to an engagement rotation speed with the motor generator in the engaged condition; and controlling the locking apparatus such that a decrease rate of the rotation speed when switching from the disengaged condition to the engaged condition in a low torque operation mode is higher than the decrease rate of the rotation speed when switching from the disengaged condition to the engaged condition in a high torque operation mode.
US08801567B2 Method and apparatus for executing an asynchronous clutch-to-clutch shift in a hybrid transmission
A hybrid transmission includes first and second electric machines. A method for operating the hybrid transmission in response to a command to execute a shift from an initial continuously variable mode to a target continuously variable mode includes increasing torque of an oncoming clutch associated with operating in the target continuously variable mode and correspondingly decreasing a torque of an off-going clutch associated with operating in the initial continuously variable mode. Upon deactivation of the off-going clutch, torque outputs of the first and second electric machines and the torque of the oncoming clutch are controlled to synchronize the oncoming clutch. Upon synchronization of the oncoming clutch, the torque for the oncoming clutch is increased and the transmission is operated in the target continuously variable mode.
US08801562B2 Multi-speed automatic transmission with fast reverse
The present disclosure provides an automatic transmission having an input adapted to couple to a torque-generating mechanism and an output coupled to the input. The transmission also includes a first rotating torque-transferring mechanism disposed along a first torque path and coupled to the input. A second rotating torque-transferring mechanism is disposed along a second torque path and is coupled to the input independent of the first torque-transferring mechanism. The transmission includes a plurality of stationary torque-transferring mechanisms, each of which is disposed between the input and output. The transmission includes a first planetary gearset, a second planetary gearset, a third planetary gearset, and a fourth planetary gearset, where each gearset includes a sun gear, a ring gear, and a carrier assembly. Moreover, the ring gear of the third planetary gearset is coupled to the carrier assembly of the second planetary gearset and the carrier assembly of the fourth planetary gearset.
US08801561B1 Power switching device for vehicle
A power switching device for vehicle has at least first and second power switching mechanisms, a shared operating mechanism, and a housing accommodating the power switching mechanisms and the shard operating mechanism, the housing being integrally formed with a boss portion having a waiting mechanism, wherein the waiting mechanism includes drive and driven cylindrical shafts, and a coil spring connecting between the cylindrical shafts, both of the cylindrical shafts and the coil spring are arranged in a same axis, and are supported on an inner peripheral surface of the boss portion through drive and driven side needle roller bearings respectively, the coil spring is arranged inside the cylindrical shafts.
US08801560B2 Transmission system for a vehicle
A transmission system has an input connected to a drive source, and an output connected to a load. The transmission system further has a transmission that includes two input shafts and an output shaft, as well as a clutch module comprising a clutch and a planetary gear set which comprises three rotational members of which a first rotational member is connected to the input, a second rotational member is coupled to the output and a third rotational member is connected to a brake. Between the input shafts and the output shaft are located three speed transforming gears and three gear clutches, and between the two input shafts is located a further clutch.
US08801559B2 Vehicular power transmitting system
A vehicular power transmitting system including an oil pump constructed to sufficiently reduce a required drive torque. A high-pressure-port discharge amount of first and second high-pressure passages of the oil pump is determined such that an amount of consumption of working oil of relatively high pressure can be afforded only by the high-pressure-port discharge amount, during steady-state running of a vehicle in which engine speed is not lower than a predetermined threshold value corresponding to a predetermined lowest target input shaft speed of a continuously variable transmission for its shifting control. The pressure of the working oil discharged from first and second low-pressure discharge passages is kept at a predetermined low level, and the required drive torque of the oil pump is sufficiently reduced.
US08801556B2 Power transmitting device
A power transmitting device makes a motor in a hybrid vehicle be smaller and lighter, prevents internal resistance and inertia of the generator motor from becoming driving resistance, and can effectively utilize energy. Via a first clutch, power is transmitted from an input shaft to a transmission shaft but power transmission vice versa is blocked, and power transmission from the input shaft to the transmission shaft can be blocked. Via a second clutch, power is transmitted from the transmission shaft to the input shaft, while power transmission vice versa is blocked. Thus, when driving using only the power of the engine, power transmission from the input shaft to the transmission shaft is blocked, thereby preventing transmission of power to the generator motor. Consequently, the generator motor can be made smaller and lighter, and energy losses can be prevented.
US08801554B2 Power transmission chain
In a roller or bushing chain, inner link plats have an oval shape, with a guide-contacting surface continuous with arc-shaped ends, and in the form of an arc having end points that are spaced from each other by a distance greater than the chain pitch but less than the greatest distance between parts of bushing holes in the inner link plates. The outer link plates have straight parallel edges parallel to the direction of chain elongation and semicircular ends continuous with the straight edges. The configuration of the inner link plates prevents the outer link plates from coming into contact with a chain guide.
US08801550B2 Blade of/for a hockey stick
A blade of/for a hockey stick having: a toe, a heel, rear face, and front face. The front face has a striking surface intermediate the toe and the heel, and a plurality of front protrusions forming a front face textured zone extending along a portion of the front face proximate the toe and the striking surface. The front protrusions are shaped to be engageable with a puck to hinder slippage of the puck along the front face when the puck is in contact with the front protrusions. The front face also has a front face reduced-texture zone (which may be at least one of a front face non-textured zone and a front face less-textured zone). The rear face may optionally be similarly configured.
US08801549B2 Folding sports goal for soccer and the like
A folding sports goal includes a U-shaped front frame which defines the goal opening, a U-shaped base frame with legs pivotally connected with the uprights in the front frame, and a pair of C-shaped side frames with opposite ends pivotally connected with the uprights of the front frame. The erected goal is shifted to a folded storage position by pivoting the side frames inwardly against the front frame, and then folding the base frame upwardly against the side frames and engaging locks which positively retain the goal in a folded storage position.
US08801543B2 Golf clubs and golf club heads
Golf club heads which include an iron type golf club head body including a ball striking face, a rear surface opposite the ball striking face (e.g., including a perimeter weighting member) and an indicator which indicates the location of the center of gravity of the golf club head body. Golf clubs including these club heads and methods of making such golf club and golf club heads also are provided.
US08801542B2 Golf club
A golf club comprises a club shaft and a golf club head attached to the tip end of the club shaft, wherein the length of the golf club is from 45 to 47 inches, the volume V of the golf club head is from 440 to 470 cu·cm, the moment of inertia M of the golf club head around the center line of the club shaft is 5500 to 6500 g sq·cm, and the ratio M/V of the moment of inertia M (g sq·cm) to the volume V (cu·cm) is from 11.0 to 13.5.
US08801541B2 Golf club
A golf club head includes a body defining an interior cavity. The body includes a sole positioned at a bottom portion of the golf club head, a crown positioned at a top portion, and a skirt positioned around a periphery between the sole and crown. The body has a forward portion and a rearward portion. The club head includes a face positioned at the forward portion of the body. The face defines a striking surface having an ideal impact location at a golf club head origin. Some embodiments of the club head have a high moment of inertia and variable thickness face.
US08801540B2 Golf club head
A golf club iron having a thin front face which is supported by a biasly connected insert that is inserted into a perimeter groove defined in the body of the club which gives the thin front face added support. The insert has a flange about its perimeter, and the perimeter groove has an opening ledge. The insert flange is slightly larger in thickness than the ledge and when the insert is biasly pushed into the perimeter groove a mechanical connection is created between the insert and the body of the club.
US08801537B1 Adjustable golf club shaft and hosel assembly
An adjustable golf club including a shaft and hosel assembly allows for dependent and independent adjustment of a golf club's face angle, loft angle, and lie angle. The adjustable shaft and hosel assembly comprises a shaft sleeve, a hosel portion, and at least one tubular adjustment piece having non-parallel upper and lower surfaces, wherein the shaft sleeve, hosel, and tubular adjustment piece each include markings that combine to form a code that correlates to a unique angular setting and is readable by an electronic device. The adjustable golf club may also comprise an audible feedback system including an indexing ring that interacts with indexing features in the tubular adjustment piece.
US08801536B2 Golf club with universal hosel and/or spacer
A golf club can include a universal hosel and/or hosel spacer that allows the golf club to be used with a variety of different sized club head shafts. The universal hosel can include multiple steps or ledges, and various inner diameters to accommodate different sized shafts. The spacer can be a self-expanding spacer, and can be pre-coated with epoxy. The spacer can fill in gaps within a hosel, so as to accommodate different sized shafts.
US08801534B1 Retriever
Disclosed is an attachment for a club. In example embodiments the attachment may be configured to fit at an end of the club, for example, a golf club. In example embodiments, the attachment may include a crown and a body. In example embodiments, the body may be configured to capture a golf ball or, in the alternative, a golf club or a flag stick. In example embodiments the body may include a first aperture and a second aperture wherein the first aperture and the second aperture are substantially aligned with one another and configured to accommodate at least one of the golf club and the flag stick.
US08801533B2 Golf clubs and golf club heads having digital lie and/or other angle measuring equipment
Golf club heads having sensors configured to measure one or more swing parameters are provided. The golf club head may include several gyroscopes and accelerometers. In one embodiment, the club head contains three gyroscopes that measure angular rate data along different orthogonal axes. At least one gyroscope may an analog gyroscope. Accelerometers may provide data regarding the three orthogonal axes associated with the gyroscopes. The club head may further include software and/or hardware that perform computer-executed methods for determining one or more swing parameters. Exemplary club heads may include a display device for displaying an output of the swing parameter(s). Further aspects of the invention relate to novel methods and algorithms for calculating measurements relating to the swing parameters.
US08801531B2 Golf grip training aid
This invention relates to a training aid (strategic Golf Grip and Swing Repeater Training Aid) to assist the golfer in performing the proper golf swing technique for the effective golf swing. This training aid will be placed on the leading wrist of the golfer to develop the proper swing technique and to create muscle memory and to allow for repeated practice for game improvement and consistency. It includes a cover with straps to wrap around the hand of the user, and incorporates a back hand plate to hold the hand and wrist in alignment and place during a golf swing. It may also incorporate a wrist plate.
US08801530B2 Grip guide apparatus and method of using the same
A grip guide apparatus is disclosed for use as a training aid. The grip guide apparatus includes a substrate and chromic material. The substrate is dimensioned to cover at least a portion of an article of sports equipment such as a handle. The chromic material is capable of changing colors in response to one or more external stimuli. Changes in color of chromic material thereby indicate whether the user has proper or improper hand placement on the article of sports equipment. The chromic material may also indicate whether the user has applied the proper or improper amount of pressure to the article of sports equipment. The substrate may include an adhesive backing to affix the grip guide apparatus to the article of sports equipment. By generating feedback from the chromic material, good habits can be formed with respect to taking a proper grip of the article of sports equipment.
US08801528B1 Golf practice device
One embodiment of a golf practice device comprising an upright support (12); a shaft (38) affixed to the upright support in a substantial horizontal orientation in predetermined height above a ground; a ball body (16) rotatably mounted to an outer end of the shaft; and a stopping member (14) attached to the upright support in a substantial horizontal orientation in position above the shaft. When a gold ball is struck by a golf club, it rotates about a horizontal axis and is stopped by the stopping member. The ball body is further slowed down by the unraveled cord (56) scratching the floor. After being hit with the full speed swing, the golf ball comes back into its initial quiet position in less than 5 seconds. Other embodiments are described.
US08801526B1 Foamed drive shaft damper
A foamed drive shaft damper may be inserted into a hollow automotive drive shaft. The damper includes foam deposited on its outer surface. The foam itself, which extends above the damper's outer surface, possesses a maximum operating temperature of 175° C. or higher.
US08801524B2 Damper apparatus
In a damper apparatus, power is transferred, in order, from a motor, to an input, to a first elastic body, to a first element, to a second elastic body, to a second element, to a third elastic body, and to an output. The first and second elastic bodies are disposed radially outward of the third elastic body, and adjacent to each other on a single circumference. The first element has an annular outer peripheral portion that surrounds the first and second elastic bodies, and a pair of contact portions that are formed on peripheral edges on respective sides of the outer peripheral portion to protrude from the peripheral edges radially inward and to face each other, and that are between and in contact with the first elastic body and the second elastic body.
US08801523B2 Methods, systems, and products for centralized control of gaming applications
Methods, systems, and products bookmark gaming applications. When a player wishes to pause a gaming application, a bookmark may be created. The bookmark identifies a location in the gaming application at which play is paused. Play may then be resumed from the bookmark, whether at a same device or at a different device.
US08801519B2 Gaming system, gaming device, and method providing one or more alternative wager propositions if a credit balance is less than a designated wager amount
Various embodiments of gaming systems, gaming devices, and methods of the present disclosure provide one or more alternative wagering propositions to a player when the player's credit balance is less than (or, in certain embodiments, less than or equal to) a designated wager amount. If the player accepts one of the alternative wager propositions, the player risks an amount of the player's remaining credit balance for a chance to win an alternative award. If the player wins the alternative award, the gaming system enables the player to play one or more plays of the wagering game at the designated wager amount. If the player does not win the alternative award, the gaming system reduces the player's credit balance by the amount risked.
US08801517B2 Method and apparatus for optimizing the rate of play of a gaming device
The invention includes a system and method for determining and achieving an optimized rate of play of a gaming device for a given player. The system monitors play at a gaming device, determines whether adjustments to parameters that effect the potential maximum rate of play should be made, and makes the appropriate adjustments. Monitoring play includes measuring such things as force applied to input buttons and tracking unnecessary button presses at inappropriate times (i.e., while the reels are still spinning). Parameters that effect the potential maximum rate of play include reel resolution time, length of bonus displays, payout rate, and the like.
US08801509B2 Ratcheting gambrel device
A device is provided for lifting, hanging, or securing an object. The device includes a hanger, a plate, and a ratcheting assembly. The hanger includes a pair of arms with hook members extending from the arms and a strut secured between the pair of arms. The plate is secured to the hanger and the ratcheting assembly. The ratcheting assembly includes a buckle with a lever pivotable relative to a body portion. The buckle also includes a pawl member that selectively engages a ratcheting gear. A strap is secured to the buckle and is selectively extendable and retractable relative to the buckle. A hook is provided at the free end of the strap.
US08801507B2 Shrimp deheading apparatus and methods
Apparatus and methods for deheading shrimp using the Venturi Effect. A shrimp-laden fluid is pumped through a conduit system and lined with one or more venturi tubes. The acceleration of the fluid through the venturis detaches the heads from the shrimp. The cross-sectional areas of the venturis each have a major axis and a shorter minor axis. The major axis is long enough to receive the majority of or all the length of a shrimp and minimize hard collisions with the entrance to the venturi that could damage the shrimp.
US08801506B2 Dust collection hood for grinding machine tools
A dust collection hood installed on a grinding machine tool which includes a driving motor and at least one grinding portion driven by the driving motor to rotate. The dust collection hood includes a circumferential wall surrounding the grinding portion and a dust collection cap. The dust collection cap is coupled with the circumferential wall to form a dust collection chamber to house the grinding portion, and includes a top fastened to the grinding machine tool. The dust collection chamber is formed at a height gradually decreased from the top towards the circumferential wall. The dust collection cap further includes a dust discharge port communicating with the dust collection chamber and an airflow guiding portion to guide airflow from the dust collection chamber to the dust discharge port. Thus a great amount of dust generated during grinding can be discharged via the dust discharge port.
US08801503B2 Grinding machine with multi-spindle grinding head
A tool head for a machine tool comprising a plurality of tool spindles with each tool spindle being rotatable about a respective tool axis. The plurality of tool spindles comprises at least a first tool spindle rotatable about a first tool axis, a second tool spindle rotatable about a second tool axis and a third tool spindle being rotatable about a third tool axis with the first, second and third tool axes being parallel to one another. The first, second and third tool spindles are arranged on the tool head whereby one of the first, second and third tool spindles faces a first direction and the other two of the first, second and third tool spindles face a second direction with the first and second directions being 180 degrees apart. The tool spindles are preferably grinding spindles on a machine for grinding bevel gear cutting tools.
US08801499B2 Blasting apparatus and method for blast processing
A blasting apparatus capable of increasing suction power to collect an abrasive without exerting any influence on processing of a work surface with the abrasive. The apparatus includes a blasting nozzle (2) blasting an abrasive (100) on a surface (200a) of work (200), a cover (10) including a surface (10a) for airflow alignment parallel to the work surface and a blast hole (10b) through which the abrasive from the nozzle passes, a nozzle case (9) including the cover and surrounding the nozzle, and a collecting case (11) covering an outer surface of the nozzle case and including a collecting passage (11c) disposed around the nozzle case, from the passage, the abrasive being collected by suction, wherein the apparatus collects the abrasive that is blasted from the nozzle and strikes the work surface from the passage through a clearance (13) provided between the airflow-alignment surface and the work surface.
US08801496B2 Reducing agglomeration of particles while manufacturing a lapping plate using oil-based slurry
Embodiments of the present invention pertain to reducing agglomeration of particles while manufacturing a lapping plate using an oil-based slurry. According to one embodiment, an oil-based slurry with particles of a known size is applied to a lapping plate. The oil-based slurry is ultrasonically mixed while applying the oil-based slurry to the lapping plate in order to reduce agglomeration of the particles.
US08801493B2 Beehive
A beehive includes a column of stacked boxes which open onto each other at their tops and bottoms, with the column bearing a cap at its top and a floor at its bottom. The boxes have access ports for ingress and egress of bees, and the column is suspended above the ground on a support post which bears a pivot such that the column can be tipped from a vertical orientation to a horizontal orientation for easy maintenance. Bars, frames, and/or screens may be hung within and atop the boxes to promote desired comb-building behaviors, with bees tending to build comb downwardly from higher boxes into lower boxes. At desired times, upper boxes bearing honey may be removed from the column and lower boxes bearing brood may be rotated to the top of the column so that the bees continuously propagate down the column.
US08801490B2 Smart stuffed toy with air flow ventilation system
A smart stuffed toy includes a head portion, a torso portion and four limbs. An air flow ventilation device is embedded within the torso portion of the smart stuffed toy to provide air circulation and reduce the settlement of carbon dioxide. The air ventilation device comprises no blades or safe fan blades. Preferably, the front torso surface covering the air flow ventilation device is made of material different from the remaining surfaces of the smart stuffed toy.
US08801487B2 Method for making emitter having carbon nanotubes
A method for making an emitter is disclosed. A number of carbon nanotubes in parallel with each other are provided. The carbon nanotubes have a number of first ends and a number of second ends opposite to the number of first ends. The first ends are attached on a first electrode and the second ends are attached on a second electrode. The first electrode and the second electrode are spaced from each other. A voltage is supplied between the first electrode and the second electrode to break the carbon nanotubes.