Document Document Title
US08765920B2 Tyrosine bioconjugation through aqueous Ene-like reactions
A new and versatile class of cyclic diazodicarboxamides that reacts efficiently and selectively with phenols and the phenolic side chain of tyrosine through an Ene-like reaction is reported. This mild aqueous tyrosine ligation reaction works over a broad pH range and expands the repertoire of aqueous chemistries available for small molecule, peptide, and protein modification. The tyrosine ligation reactions are shown to be compatible with the labeling of native enzymes and antibodies in buffered aqueous solution. This reaction provides a novel synthetic approach to bispecific antibodies. This reaction will find broad utility in peptide and protein chemistry and in the chemistry of phenol-containing compounds.
US08765914B2 Interleukin-B30 proteins
Purified genes encoding a cytokine referred to as interleukin-B30 (IL-B30) from a mammal, and reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using the reagents and diagnostic kits are also provided.
US08765912B2 Taste receptors of the T1R family from domestic dog
The present invention relates to the discovery of several genes of the domestic dog (Canine familiaris) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the canine Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal such as a dog by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.
US08765911B2 Evaluation of copolymer diethylamide
Methods of analyzing glatiramer acetate (GA) or a polymeric precursor thereof are provided. The methods can include determining a level of one or more diethylamide-modified amino acids in a sample comprising GA or a polymeric precursor thereof, and selecting at least a portion of the sample based on the assessment of the one or more diethylamide-modified amino acids in the sample.
US08765910B2 Method for amidating polypeptides with basic amino acid C-terminals by means of specific endoproteases
The invention relates to a method for producing C-terminal amidated dibasic or polybasic peptides, consisting in reacting two peptides in the presence of trypsin biologically active enzymes and, if necessary, in purifying the thus obtainable compounds of formula (I) by means of protein chemistry.
US08765908B2 Compositions for improving bone mass
The present invention provides a therapeutic composition, and method of use thereof, for improving bone mass, rigidity, or strength, or preventing and treating bone loss via modulation of the RANK signaling pathway. The therapeutic composition of the present invention comprises a RYBP peptide, or fragments thereof, that specifically interact with a motif of RANK to regulate osteoclastogenesis. The present invention further provides a composition, and method of use thereof, comprising a modulator that is capable of modulating the RYBP-RANK interaction, or modulating an effector in the RANK signaling pathway through the RYBP-RANK interaction.
US08765907B2 Production and use of antitumoral antibiotic and insecticidal cyclodepsipeptides
The invention relates to a compound of the general structure (I), where R is a hydrogen atom (II) or an unsubstituted, monosubstituted or polysubstituted C1-C20-alkyl, wherein the alkyl is straight, branched, cyclic and/or partially unsaturated, or an unsubstituted, monosubstituted or polysubstituted phenyl group.
US08765906B2 Method for producing polyacrylic acid (salt) type water absorbent resin powder
A water absorbent resin having less fine powder or powdery dust and a controlled particle size is provided, and the water absorption rate of the water absorbent resin is increased by a simple method at low cost, while maintaining or improving other physical properties such as liquid permeability. Disclosed is a method for producing a polyacrylic acid (salt)-type water absorbent resin powder, which includes, in sequence, a step of polymerizing an aqueous solution of acrylic acid (salt)-type monomer; a step of gel-crushing a gel of a water-containing gel-like crosslinked polymer during polymerization or after polymerization; a step of drying the water-containing gel-like crosslinked polymer; and a step of pulverizing and classifying the dried polymer, wherein water absorbent resin fine particles having a particle size of less than 150 μm or a hydrated-particles thereof is added to a step prior to the drying step, and in the drying step, hot air drying is carried out with a hot air having an average flow velocity of 1.0 to 3.0 [m/s], a dew point of 30° C. to 100° C., and a hot air temperature of 140° C. to 235° C.
US08765905B2 Proton-conducting membrane and use thereof
The present invention relates to a novel proton-conducting polymer membrane based on polyazoles which can, owing to its excellent chemical and thermal properties, be used for a variety of purposes and is particularly suitable as a polymer-electrolyte membrane (PEM) for the production of membrane electrode units for so-called PEM fuel cells.
US08765903B2 Carbazole polymer and method of manufacturing same
A carbazole polymer containing a repeating unit represented by a chemical structure 1: where R represents an aliphatic or alicyclic bifunctional group, Ar represents an aromatic hydrocarbon or heterocyclic ring bifunctional group, and Ar1 represents an aromatic hydrocarbon or heterocyclic ring monofunctional group.
US08765901B2 Spandex compositions for high speed spinning
A spandex comprising a polyurethane or polyurethaneurea reaction product of at least one diisocyanate compound and a poly(tetramethylene-co-ethyleneether) glycol comprising constituent units derived by copolymerizing tetrahydrofuran and ethylene oxide wherein the percentage of ethylene ether moieties is from about 16 to about 70 mole percent with at least one chain extender selected from the group consisting of diamines and diols and at least one chain terminator wherein the spandex is spun at a speed in excess of about 750 meters per minute.
US08765897B2 Hydrophilic crosslinked polymer
The present invention relates to a hydrophilic crosslinked polymer, preferably in the form of porous particles, and to the preparation and use thereof. The polymer according to the invention is produced by polymerization from chain-forming hydrophilic vinyl ethers and crosslinking, preferably heterocyclic divinyl ethers.
US08765895B2 Crosslinked polyolefins for biomedical applications and method of making same
The invention relates to a polymer composition that includes a branched alkene which is cationically polymerizable as well as a glass-forming comonomer and/or a vinyl comonomer containing benzocyclobutene as the pendant group. The structure of the polymer composition can take various forms: linear random copolymer, linear block copolymer, star random copolymer, star block copolymer, and other hyperbranched polymers. The copolymer composition can undergoes crosslinking at elevated temperatures (preferably above 180° C.).
US08765887B2 Process and catalyst system for polydiene production
A process for preparing a polydiene, the process comprising the step of polymerizing conjugated diene monomer with a lanthanide-based catalyst system in the presence of a vinylsilane, an allylsilane, or an allylvinylsilane.
US08765886B2 Multifunctional chain shuttling agents
The invention generally relates to chain shuttling agents (CSAs), a process of preparing the CSAs, a composition comprising a CSA and a catalyst, a process of preparing the composition, a processes of preparing polyolefins, end functional polyolefins, and telechelic polyolefins with the composition, and the polyolefins, end functional polyolefins, and telechelic polyolefins prepared by the processes.
US08765885B2 Apparatus and process for the polymerisation of olefins
Apparatus and process for gas phase polymerisation of olefins. The apparatus includes (a) a reaction zone having a grid at its base, (b) an inlet located in the lower half of the reaction zone for introducing a reaction gas to the reaction zone, (c) an outlet located in the upper half of the reaction zone for removing the reaction gas from the reaction zone, and (d) a solids separation unit having an inlet fluidly connected to the outlet for removing the reaction gas from the reaction zone. The inlet of the solids separation unit is located at a vertical height lower than the outlet for removal of reaction gas from the reaction zone and such that the angle to the horizontal of a straight line drawn between the inlet of the solids separation unit and the outlet for removal of reaction gas from the reaction zone is greater than 20°.
US08765882B2 Polythiophene based active layer for solar cells
New monomers, polymers, and blends of polymers with an electron acceptor are provided, e.g., for use in a photovoltaic device. The electron acceptor can be a fullerene derivative and the polymer can comprise monomer units according to the formula: wherein L′ is L-C(O)O-J, L-C(O)NR′-J, L-OCO-J′, L-NR′CO-J′, L-SCO-J′, L-O-J, L-S-J, L-Se-J, L-NR′-J or L-CN; L is a linear or branched alkylene group having from 1 to 10 carbon atoms; J is a hydrogen atom or a linear or branched alkyl group having from 1 to 4 carbon atoms; J′ is a group having from 1 to 10 carbon atoms, being saturated or unsaturated, linear or branched, optionally comprising a phenyl unit; and R′ is a hydrogen atom or a linear or branched alkyl group having from 1 to 4 carbon atoms.
US08765881B2 Methods of making polydiorganosiloxane polyoxamide copolymers
A method of preparing polydiorganosiloxane polyoxamide copolymers is described. These copolymers have at least one polydiorganosiloxane segment and at least two aminooxalylamino groups. The method can be used in the presence or absence of a solvent. Intermediates involved in the preparation of the copolymers are also described.
US08765874B2 Ethylene based polymers and articles made therefrom
Provided are ethylene-based polymer compositions, articles made therefrom, and methods of making the same. Ethylene-based polymer compositions include blends of a linear low density polyethylene prepared with metallocene catalyst and a low density polyethylene. The linear low density polyethylene may optionally have about five mole percent or less of monomer units derived from an alpha-olefin comonomer. Articles composed of such ethylene-based polymer compositions, such as blown films, exhibit favorable physical properties, including excellent optical properties and retained strength i.e., mitigation of expected decline in physical strength due to LDPE addition.
US08765872B2 4-methyl-1-pentene polymer, resin composition containing 4-methyl-1-pentene polymer, masterbatch thereof, and formed product thereof
[Object] To provide a resin composition with excellent mold releasability and blocking resistance.[Solution] A resin composition containing a 4-methyl-1-pentene polymer includes 0.01 to 10 parts by mass of a 4-methyl-1-pentene polymer (B) per 100 parts by mass of at least one resin (A) selected from the group consisting of thermoplastic resins and thermosetting resins, wherein the 4-methyl-1-pentene polymer (B) has (B1) an intrinsic viscosity [η] of 0.01 or more but less than 0.50 dl/g measured at 135° C. in a decalin solvent.
US08765865B2 Heat resistant polylactic acid compositions
A significant disadvantage of the use of polylactic acid (PLA) has been overcome by the use of styrene maleic anhydride copolymer in combination with an epoxy functional styrene-acrylate oligomeric chain extender. The composition also often exceeds a threshold of 65° C. in heat deflection temperature.
US08765863B2 Triethylamine functionalized elastomer in barrier applications
A halogenated elastomer partially functionalized with triethylamine, in a mixture with fiiier and a cure package, suitable for use as an air barrier in an innertube or tire innerliner, is disclosed. The halogenated elastomer can be a polymer comprising C4 to C7 isoolefm derived units, para-alkylstyrene derived units, para-(haloalkylstyrene) derived units, and para-(triethylammoniumalkylstyrene) derived units. The Mooney viscosity of the elastomer can be controlled by the degree of triethylamine functionalization. Also disclosed is a method for making an article using the tri ethy iamine-functionalized elastomer.
US08765861B2 Masterbatch pellet, production method therefor and polyamide resin composition containing masterbatch pellet
A masterbatch pellet is provided for obtaining a polyamide resin composition excellent in mechanical strength and heat aging resistance. The masterbatch pellet is obtained by melt-kneading a raw material component containing a thermoplastic resin (A) and a metal oxide (B), wherein a content of the metal oxide (B) is 0.5% by mass or more and a fraction of the metal oxide (B) after the melt kneading is present as an aggregated particle of 5 μm or more in a major axis length. A proportion of the aggregated particle of 5 μm or more in a major axis length in a whole metal oxide after the melt kneading is preferably 30% by mass or less.
US08765858B2 Polyphenylene sulfide resin composition with improved thermal conductivity and surface appearance and articles thereof
A polyphenylene sulfide resin composition comprises (A) about 30 to about 50% by weight of a polyphenylene sulfide resin; (B) about 1 to about 5% by weight of an amorphous polyamide resin; and (C) about 45 to about 69% by weight thermally conductive insulating fillers.
US08765856B2 Thermosetting polymer-based composite materials
A lead-free, non-toxic composite material including a thermosetting polymer and at least one of a heavy particulate filler, a light particulate filler or a combination thereof. The composite material may be utilized in manufacturing articles used in radiation shielding applications.
US08765855B2 Reaction-based laser marking compositions, systems and methods
An ink formulation comprises a binder and at least one marking component, which comprises at least one metal oxide or oxyanion and at least one oxidizing/reducing agent, which absorbs laser irradiation between wavelengths of 780-10,600 nm, thereby causes the formulation to change color.
US08765854B2 Ethylene-vinyl alcohol copolymer resin composition of low carboxylic acid content
An ethylene-vinyl alcohol copolymer resin having low odor of acetic acid and good long-run workability is provided. The ethylene-vinyl alcohol copolymer resin which contains an alkali metal salt (A) and has a very low extractable carboxylate content is obtained by a method including contacting the ethylene-vinyl alcohol copolymer resin with an aqueous solution containing carbon dioxide gas.
US08765851B2 Free radical initiator modified hot melt adhesive composition including functionalized polyethylene and propylene-alpha-olefin polymer
A hot melt adhesive composition that includes a first copolymer that includes the reaction product of a functionalized polyethylene, a propylene-alpha-olefin polymer that includes at least 50 mole % propylene and has a viscosity of no greater than 10,000 centipoise at 190° C., a ratio of z average molecular weight (Mz) to number average molecular weight (Mn) (Mz/Mn) of greater than 20, and a ratio of Mz to weight average molecular weight (Mw) (Mz/Mw) of greater than 3.0, and a free radical initiator.
US08765847B2 Asphalt compositions with cracking resistance additives
Methods are provided for upgrading the quality of an asphalt. The methods include mixing an asphalt feed with a cracking resistance additive that improves the low temperature properties of the asphalt while leaving the high temperature properties unchanged or minimally changed. The cracking resistance additive corresponds to a compound that is a liquid at both the low temperature performance grade for the asphalt and at mixing and/or storage temperature for the asphalt. Examples of compounds that, in an appropriate molecular weight range, are liquids across this broad temperature range include polyalphaolefins, alkylated naphthalenes, and organic esters.
US08765831B2 Photocurable resin composition
Provided is a photocurable resin composition, which has sensitivity equal to or greater than existing compositions, has alkali development properties, and which produces a cured product that does not become brittle with changes in temperature, and which also has excellent reliability in terms of water resistance, electrical insulating properties, PCT resistance, and the like. The photocurable resin composition comprises a carboxyl group-containing resin, a photopolymerization initiator, a vinyl group-containing elastomer, and a styryl group-containing compound.
US08765830B2 Polyimide foam and method for producing same
Disclosed is a polyimide foam made of an aromatic polyimide composed of a tetracarboxylic acid component, which is composed of 0 to 90% by mole of a 3,3′,4,4′-biphenyltetracarboxylic acid component and 100 to 10% by mole of a 3,3′,4,4′-benzophenone tetracarboxylic acid component and/or a 2,3,3′,4′-biphenyltetracarboxylic acid component, and a diamine component, which is composed of 50 to 97% by mole of m-phenylenediamine and 50 to 3% by mole of 4,4′-methylenedianiline. The polyimide foam can be produced easily, has uniform and fine cells, and has the mechanical properties required for practical use as a foam, such as flexibility that prevents the foam from cracking easily even when deformed and excellent cushioning properties, as well as heat resistance that can resist use at high temperatures.
US08765828B2 Flexible foams
Polyurethane foams of improved resilience properties can be produced from: a) a polyisocyanate, b) a polyether polyol or polyester polyol, c) a blowing agent, d) one or more optional additives or auxiliary compounds, and e) a redispersible polymer powder based on a homopolymer or copolymer of one or more monomers from the group consisting of vinyl esters of un-branched or branched alkylcarboxylic acids having from 1 to 15 carbon atoms, methacrylic esters and acrylic esters of alcohols having from 1 to 15 carbon atoms, vinylaromatics, olefins, dienes and vinyl halides.
US08765821B2 Oil-in-water type cosmetic emulsion
The invention provides an oil-in-water type cosmetic emulsion which can be applied to the skin without stickiness, and impart resilient and supple feel to the skin, while having good stability without causing viscosity decrease or separation even during a long-term storage. The oil-in-water type cosmetic emulsion comprises (a) a higher alcohol having 14 to 22 carbon atoms, (b) a hydrophilic polyoxyethylene alkyl ether, and (c) a glycerin monoalkyl ether, wherein alkyl moieties in (b) and (c) are linear saturated alkyl chains, and molar concentrations of (a) to (c) satisfy a relation [(b)+(c)]/(a)=0.1 to 1.0, and preferably satisfy a relation [(a)+(c)]/(b)=3 to 20.
US08765820B2 Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2
Tranylcypromine derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compounds belong to the structural formula (I) wherein A and R3 are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to compositions containing them and to therapeutic use thereof.
US08765819B2 Composition comprising benzoic acid in combination with organic acid preservatives as active ingredients and the use thereof
The present invention relates to the use of low content of benzoic acid and/or sodium salt thereof in combination with one or more organic acid preservatives as active ingredients in the manufacture of a vaginal composition, wherein the composition has weak inhibition effect on normal vaginal lactobacilli while has strong inhibition effect on vaginal fungi and/or pathogenic vaginal lactobacilli, the organic acid preservatives are selected from the group consisting of dehydroacetic acid and/or sodium salt thereof, propionic acid and/or a salt thereof, sorbic acid and/or a salt thereof. The composition of the present invention is particularly useful in inhibiting vaginal fungi, and/or inhibiting pathogenic vaginal lactobacilli, and/or promoting normal vaginal lactobacilli, and/or maintaining normal vaginal acidity, and/or modulating vaginal microecosystem, and/or modulating vaginal microbials, and/or selectively decontaminating vagina.
US08765816B2 Inhibitors of cognitive decline
Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods of treating, inhibiting, and/or abatement of cognitive decline and/or Alzheimer's disease with a compound or pharmaceutically acceptable salt of the invention are also provided. Also provided are methods of preparing the compounds/compositions of the invention.
US08765812B2 Therapeutic compounds
Substituted cinnamoyl anthranilate compounds exhibiting anti-fibrotic activity; or derivatives thereof, analogues thereof, pharmaceutically acceptable salts thereof, and metabolites thereof; with the proviso that the compound is not Tranilast.
US08765809B2 Ester derivative and use thereof
A compound represented by the following formula (I′) wherein X1 is a methylene group, an ethylene group, a trimethylene group or a vinylene group, X2 is a divalent group represented by the following formula A or B, Y is an ethylene group or a vinylene group, m and n are each an integer of 0 to 7, which satisfy m+n=0 to 8, R1 and R2 are each independently a hydrogen atom, a methyl group or an ethyl group, provided that when X1 is a methylene group, then X2 is not a divalent group represented by the formula A, and when X1 is a vinylene group, then X2 is not a divalent group represented by the formula A. The compound is a stable capsinoid derivative, and is useful as an active ingredient of an external blood circulation enhancer or a cosmetic composition, a pharmaceutical composition, or a food composition.
US08765807B2 Esters of capsaicin for treating pain
The present invention relates to the formulations of ester derivatives of capsaicin and ester derivatives of myristoleic acid. These derivatives are capable of reverting to the active parent compound following enzymatic or chemical hydrolysis. These derivatives have a higher lipophilicity, lipid solubility and less irritation to the skin than the parent compound, and hence are better able to be incorporated into certain pharmaceutical formulations, including cream and ointment pharmaceutical formulations. The pharmaceutical compositions are useful for pain management in mammals in vivo and have been contemplated to be used in the treatment of various pains in humans.
US08765804B2 Pharmaceutical compositions comprising lignans and their derivatives for treating hyperplastic diseases
The present invention relates to a pharmaceutical composition comprising specific compounds which may be obtained from Leontopodium alpinum Cass. (Edelweiss). A preferred compound is leoligin (=(2S,3R,4R)-4-(3,4-dimethoxybenzyl) -2-(3,4-dimethoxyphenyl)tetrahydrofuran-3-yl]methyl(2Z)-2-methylbut-2-enoat]). Corresponding means and methods in respect of medical uses of the compounds are described. The present invention also provides a medical device comprising, containing or having been contacted with the compound. The compounds provided herein may particularly be used in the treatment of hyperplastic diseases, in particular intimal hyperplasia, e.g. stenosis, restenosis, atherosclerosis and the like. Also envisaged herein is the use of these compounds in the treatment of proliferative diseases, such as leukemia, prostate cancer and lung cancer.
US08765800B2 Crystalline (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine
Crystalline forms of (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine, pharmaceutical compositions and medicaments comprising these crystalline modifications, the use of these modifications as well as a process for the enrichment of such crystalline modifications.
US08765795B2 Isothiazolone-containing preservative with improved effectiveness
A preservative which comprises a) one or more isothiazolones and b) one or more glycerol monoalkyl ethers, and the use of the preservative for microbicidal finishing of cosmetic and pharmaceutical products.
US08765790B2 Positive allosteric modulators of nicotinic acetylcholine receptor
The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor.
US08765787B2 Methods of treatment of xerophthalmia with self-preserving ocular formulations of norketotifen
Self-preserving ophthalmic formulations containing norketotifen and methods of making the same and the use thereof in patients suffering from xerophthalmia are disclosed. The methods also comprise administering to the eyes of a mammal in need thereof, self-preserving topical ophthalmic formulations containing norketotifen, free from any added preservative.
US08765784B2 Positive allosteric modulators of MGLUR2
The present invention is directed to 5-substituted 1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-one derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia.
US08765781B2 Bis-carbazole DNA intercalating agents for antitumor therapy
The present invention is a DNA intercalating agent represented by the structure Y—Z—Y, wherein Y is an antitumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, containing at least two aromatic rings, or at least two alicyclic rings, said rings being linked in a 1,4 or 1,3 manner. Methods of inhibiting cancer cells and treating subjects having cancer with these agents are also provided.
US08765777B2 Compositions and methods of use for tyrosine kinase inhibitors to treat pathogenic infection
Compositions and methods are provided for using tyrosine kinase inhibitors to treat pathogenic infection. In particular, methods for using Abl-family tyrosine kinase inhibitors to treat pathogenic infection are provided. Infections to be treated according to the present invention include, particularly, those caused by microbial pathogens such as bacteria and viruses.
US08765770B2 Substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as potassium channel modulators
This invention relates to novel substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as modulators of potassium channels. In other aspects the invention relates to the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
US08765765B2 Metabolites of (thio) carbamoyl-cyclohexane derivatives
The present invention relates to metabolites of(thio)-carbamoyl cyclohexane derivatives, particularly, metabolites of trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-N,N-dimethylcarbamoyl-cyclohexylamine and pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing the same and to their use in the treatment and/or prevention of a conditions which requires modulation of dopamine receptors.
US08765761B2 6-(1H-indazol-6-yl)-N-{4-[2-methyl-1-(morpholin-4-yl)propan-2-yl]phenyl}imidazo[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a syk inhibitor
An imidazopyrazine having the structure or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.
US08765760B2 [1,2,4] triazol [1,5-a] pyrazines useful as inhibitors of phosphodiesterases
Provided herein are compounds of formula (I): A-L-B  (I) and pharmaceutically acceptable salts and stereoisomers thereof, wherein A is wherein X is (i) CR1 or N, or (ii) O or NR2, each Y is independently N or CR3, and each Z is independently N or C, wherein R1, R2 and R3 are defined in the specification; L is a linker, and B is a multicyclic ring; methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are inhibitors of phosphodiesterases and useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, e.g., neurological disorders, psychosis, schizophrenia, obesity and diabetes.
US08765759B2 Monocyclic CGRP receptor antagonists
The present invention is directed to compounds of the formula: (wherein variables A1, A2, A3, G1, G2, G3, G4, J, Ea, Eb, Ec, R6, R7, and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
US08765744B2 Azaspirohexanones
The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, R7, A, Z and m are as defined herein. The compounds of formula (I) are inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
US08765740B2 Cytotoxic benzodiazepine derivatives
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
US08765738B2 Carbazole compounds and therapeutic uses of the compounds
Compounds of the general structural formula (I) and (II) and use of the compounds and salts and hydrates thereof, as therapeutic agents are disclosed. Treatable diseases and conditions include cancers, inflammatory diseases and conditions, and immunodeficiency diseases.
US08765736B2 Benzenesulfonamide compounds and the use thereof
The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1, R2, R3, Z and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula I to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
US08765735B2 Isoxazolines as inhibitors of fatty acid amide hydrolase
The present invention provides isoxazoline FAAH inhibitors of the formula (I): or pharmaceutically acceptable forms thereof, wherein each of G, Ra, Rb, Rc, and Rd are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable form thereof, and a pharmaceutically acceptable excipient.The present invention also provides methods for treating an FAAH-mediated condition comprising administering a therapeutically effective amount of a compound of formula (I), or pharmaceutically acceptable form thereof, to a subject in need thereof.
US08765732B2 Aryl- or heteroaryl-substituted benzene compounds
The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
US08765728B2 [1,5]-diazocin derivatives
The present invention relates to compounds of formula (I) compositions, in particular pharmaceutical compositions, and medicaments comprising at least one compound of formula (I). The invention also relates to the use of such a compound for manufacturing a medicament. In particular the medicament and the pharmaceutical composition are intended to treat diseases linked with insulin regulation problems, such as diabetes. This invention aims also to methods for treating or preventing such diseases.
US08765725B2 Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).
US08765721B2 Composition comprising phosphatidyl serine and an antigen or allergen and the use thereof
Provided is a composition comprising a phosphatidyl serine receptor ligand for use in immune therapy. The composition may include an antigen or allergen together with the phosphatidyl serine receptor ligand. The compositions may be used for any type of immune therapy, such as immune modulation to an environmental antigen or allergen, down regulation of immune hypersensitivity reactions, and stimulation of antigen or allergen specific IgA and/or IgG4.
US08765720B2 Combination therapy for the treatment of multiple myeloma
The present invention provides a method for treating multiple myeloma in a subject, comprising the step of administering to the subject a combination of COMPOUND 1 and bortezomib. The invention further provides a method for treating multiple myeloma in a subject, comprising the step of administering to the subject a combination of COMPOUND 1 and melphalan.
US08765719B2 Therapeutic drug for adult T-cell leukemia
An object is to provide a novel therapeutic drug for adult T-cell leukemia having an ATL cell specific antitumor effect. The therapeutic drug for adult T-cell leukemia according to the invention is characterized by containing a compound represented by the formula I or a prodrug thereof, wherein R1 is H, OH, an alkoxy group, an acyl group, or a thioacyl group, R2 is an acyl group, a thioacyl group, CONR7R8, or CSNR7R8 (R7 and R8 being each independently H, an alkyl group containing 1 to 3 carbon atoms, or a phenyl group), or R1 and R2 together may form a ring, X1 and X2 may be the same or different and are each —CR3R4—, —SiR3R4— or oxygen, and R3 and R4 may be the same or different and are each an alkyl group containing 1 to 6 carbon atoms.
US08765718B2 Cosmetic preparation comprising silicone
The present invention discloses a cosmetic preparation which comprises 20 mass % or more of an oil ingredient comprising the following components (A) and (B), and said oil ingredient comprising 50 mass % or more of the component (B): (A): one or more members selected from the group consisting of an ester compound(s) represented by the following formula (I) and/or formula (II) of erythritol and/or erythritol condensate with a fatty acid(s); polycondensates of erythritol and/or erythritol condensate, the above-mentioned ester compound(s) and a polycarboxylic acid(s); polycondensates of a fatty acid(s) with a polycondensate(s) of erythritol and/or erythritol condensate with a polycarboxylic acid(s); and polycondensates of erythritol and/or erythritol condensate, a fatty acid(s) and a polycarboxylic acid(s); and (B): silicone. This cosmetic preparation is excellent in compatibility with an oil agent and affinity for a water-base component. Particularly, the cosmetic preparation is excellent in compatibility with an oil agent and affinity for a water-base component even if the content of silicone is high.
US08765714B2 Sulphated hyaluronic acid for treating degenerative osteoarthritis
This invention relates to oral and intra-articular formulations based on sulphated hyaluronic acid which are effective in the treatment of degenerative osteoarthritis.
US08765711B2 Method for protecting and treating at least one muscarinic receptor from dysfunction resulting from free radical damage
Methods and compositions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and cofactors, by administering pyrophosphate analogs or related compounds.
US08765710B2 2′,4′-substituted nucleosides as antiviral agents
Embodiments of the invention are to compounds, methods, and compositions for use in the treatment of viral infections. More specifically embodiments of the invention are 2′,4′-substituted nucleoside compounds useful for the treatment of viral infections, such as HIV, HCV, and HBV infections.
US08765706B2 Composition comprising rna derived from lactic acid bacterium as effective component
A composition has an immunomodulation action, and comprises an RNA derived from a lactic acid bacterium as an effective component. Alternatively, a composition has a cytokine production-modulating action, and includes an RNA derived from a lactic acid bacterium as an effective component.
US08765704B1 Modified small interfering RNA molecules and methods of use
The present invention provides double-stranded RNA molecules that mediate RNA interference in target cells, preferably hepatic cells. The invention also provides double-stranded RNA (dsRNA) molecules that are modified to be resistant to nuclease degradation, which inactivates a virus, and more specifically, hepatitis C virus (HCV). The invention also provides a method of using these modified RNA molecules to inactivate virus in mammalian cells and a method of making modified small interfering RNAs (siRNAs) using human Dicer. The invention provides modified RNA molecules that are modified to include a dsRNA or siRNA wherein one or more of the pyrimidines in the RNA molecule are modified to include 2′-Fluorine. The invention also provides dsRNA or siRNA in which all pyrimidines are modified to include a 2′-Fluorine. The invention provides that the 2′-Fluorine dsRNA or siRNA molecule is further modified to include a two base deoxynucleotide “TT” sequence at the 3′ end of the molecule.
US08765702B2 Composition and methods for modulating cell proliferation and cell death
Described herein are compositions and methods for modulation of p53-dependent cell death and cell proliferation. The compositions are microRNAs and associated nucleic acids.
US08765698B2 Methods and products for reawakening retrocyclins
Products and methods are provided for the restoring the endogenous expression of theta-defensins, such as retrocyclin-1, in mamallian cells. The present invention also includes products and methods for inhibiting sexually transmitted virus entry, e.g., HIV-1 virus entry, into a mammalian cell via, for example, administering to a subject an amount of a read-through mediating agent sufficient to induce exogenous expression of an amount of retrocyclin nonapeptides in the mammalian cell.
US08765697B2 Pesticide compositions exhibiting enhanced activity
Pest controlling compositions exhibiting enhanced pesticidal activity levels are disclosed. In one embodiment, a composition includes at least one pesticide, at least one proteinaceous material and at least one polymeric material. In this embodiment, the composition exhibits enhanced pesticidal activity levels compared to a composition dissimilar only in not having the at least one proteinaceous material and the at least one polymeric material. Still, alternative embodiment pesticide compositions exhibiting enhanced activity levels are disclosed.
US08765695B2 Use of ginsenoside RG1, its metabolites ginsenoside RH1 and/or PPT
The present invention relates to use of an active ingredient selected from ginsenoside Rg1, its metabolites ginsenoside Rh1 and Ppt for preparing a medicament and a health care product for improving sexual function of male mammals, and for providing the effect of spermatogenesis. The present invention further relates to a pharmaceutical composition for improving sexual function of male mammals, and/or for providing the effect of spermatogenesis, which comprises at least one active ingredient selected from ginsenoside Rg1, its metabolites ginsenoside Rh1 and Ppt, and a pharmaceutically acceptable excipient.
US08765694B2 Method for treating obesity
The present invention is directed to methods for treating obesity, reducing excessive body weight, treating an obesity-related condition, treating unwanted localized fat deposits, and treating areas of cellulite. The method comprises the steps of first identifying a subject in need thereof, and administering to the subject an effective amount of rhamnolipids. A pharmaceutical composition comprising rhamnolipids can be applied by any accepted mode of administration including oral, intranasal, subcutaneous, percutaneous, intravenous, or intracutaneous administration.
US08765691B2 Osmolytes for the treatment of allergic or viral respiratory diseases
The present invention relates to the use of osmolytes for treating allergic or viral respiratory diseases, e.g. allergic rhinitis (hay fever) as well as rhinovirus and/or adenovirus infections. The invention also relates to a medicament preparation containing one or more compounds from the group of osmolytes. The group of osmolytes used in the invention comprises various low-molecular substances, more specifically ectoine, 4,5,6,7-tetrahydro-2-methyl-1H-[1,3]-diazepine-4-S-carboxylic acid (homoectoine), hydroxyectoine, di-myo-inositol-phosphate (DIP), to cyclic 2,3-diphosphoglycerate (cDPG), 1,1-diglycerol phosphate (DGP), β-mannosylglycerate (firoin), β-mannosylglyceramide (firoin-A), dimannosyl-diinositol phosphate (DMIP), glucosylglycerol, taurine, betaine, citrulline, and/or a derivative, e.g. an acid, salt, or ester of said compounds.
US08765690B2 Treatment of cancer with glufosfamide in patients not receiving insulin therapy
The co-administration of glufosfamide and a glucose lowering drug other than insulin is efficacious in cancer treatment.
US08765686B2 Polypeptides for treating and/or limiting influenza infection
Isolated polypeptides that recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection, or to diagnose or monitor progression of an influenza infection are described.
US08765684B2 Solid materials of {[(2S,5R,8S,11S)-5-benzyl-11-(3-guanidino-propyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid} and methods for obtaining them
The instant invention relates to novel solid materials of {[(2S,5R,8S,11S)-5-benzyl-11-(3-guanidino-propyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid}, methods for producing them, and the use of said solid materials in pharmaceuticals.
US08765682B2 Method for in vivo residue-specific DOPA incorporation into mussel adhesive proteins
The present invention relates to recombinant mussel adhesive protein wherein a DOPA residue is in vivo incorporated instead of a tyrosine residue, and a method for producing the same. More specifically, the present invention relates to recombinant mussel adhesive protein wherein a DOPA residue is incorporated instead of a tyrosine residue, and a method for producing the same, and a transformant for producing the recombinant mussel adhesive protein.
US08765668B2 Methods of synthesis of β-aminobutyryl substituted compounds
The present invention relates to process to prepare β-aminobutyryl compounds having β-amino acid core structural moieties and optionally having γ-phenyl and/or heterocyclic structural moieties. Such compounds are useful as key structure framework of modern drug chemistry.
US08765659B2 Cationic polymer stabilized microcapsule composition
The present invention relates to the use of a cationic polymer to provide stability to microcapsules in a composition, wherein the microcapsule comprises a shell encapsulating materials having an average C log P of at least 2.5 and more than 60% by weight of the encapsulated materials have a C log P of at least 3.3. The cationic polymer is derived from the polymerization of 5 to 100 mole percent of a cationic vinyl addition monomer, 0 to 95 percent acrylamide, and 5 to 500 ppm of a tetrafunctional vinyl addition monomer cross-linking agent. The cationic polymer and encapsulated material may be used, for example, in a fabric softener composition.
US08765647B2 Method and chemical agent for reduction of water production from oil and gas containing wells
Method and agent for reducing water production from oil and gas wells. The agent comprises polymer, cross-linked particles which are stable in water-free solvents. The particles are manufactured in an oil-in-oil emulsion and are cross-linked with at least one water-stable cross-linker and at least one water-labile cross-linker. The water-labile cross-linker is chosen so that when it is opened or broken in a reaction with water a hydrophilic seat is formed which increases the particle's ability to swell in water. The particles furthermore comprise a controlled amount of an immobilized chemical compound which by means of the reaction between water and reactive groups in the polymer skeleton, become able to form chemical bonds to another particle, to another reactive seat in the same particle or to another compounds thereby increasing the agent's stability in the formation.
US08765645B2 Lost circulation materials and methods of using the same
A method of servicing a wellbore in contact with a subterranean formation, comprising placing a wellbore servicing fluid comprising a drilling fluid and lost circulation material into a lost circulation zone within the wellbore, wherein the lost circulation material comprises a polyelectrolyte multilayer material and a first counterion. A wellbore servicing fluid comprising a drilling fluid and a lost circulation material comprising a polyelectrolyte multilayer material and a counterion comprising a halide, wherein the LCM has a first state that is hydrophilic. A tunable lost circulation material comprising a base material, a polyelectrolyte multilayer on said base material, wherein the polyelectrolyte multilayer comprises a first electrolyte layer, a second electrolyte layer, and a charged surface, and a counterion, wherein wettability of the lost circulation material is a function of the counterion.
US08765642B2 Combinatorial probe libraries
Provided herein is a set of reagents comprising: a plurality of at least three probe libraries, wherein each library of the plurality comprises one or more probe sets that are each specific for a target; and at least one of the libraries comprises a probe set that is present in another of the libraries. The plurality of libraries can be hybridized to spatially separated targets, simultaneously or sequentially. The identity of a spatially separated target can be determined by identifying which combination of the multiple libraries hybridize thereto.
US08765639B2 Alkoxylated asymmetric alkylamine surfactants as adjuvants
The present invention generally relates to a herbicidal formulation that comprises at least one phenoxy acid herbicide or an agriculturally acceptable salt or derivative thereof, and a surfactant adjuvant, wherein said surfactant adjuvant comprises at least one alkoxylated asymmetric alkylamine surfactant having the formula (I) wherein R1 is a straight or branched chain, saturated or unsaturated hydrocarbyl group having from 8 to 24 carbon atoms; R2 is a C1-C4 alkyl group or a benzyl group; A is an alkylene group containing from 2-4 carbon atoms; x is 1-30; and y is 0-10; or a quaternised derivative of (I) having the formula (II) wherein R1 is a straight or branched chain, saturated or unsaturated hydrocarbyl group having from 8 to 24 carbon atoms; R2 is a C1-C4 alkyl group or a benzyl group; A is an alkylene group containing from 2-4 carbon atoms; x is 1-30; y is 0-10; R3 is a C1-C4 alkyl group; and Y− is an anion. The invention also relates to a method for controlling unwanted vegetation which comprises applying an effective amount of the aforementioned herbicidal formulation to said unwanted vegetation.
US08765637B2 Crop oil concentrate adjuvants containing amine surfactants
In agricultural practice it is known to use emulsifiable oils (commonly referred to a Crop Oil Concentrates, COC) as bioefficacy enhancers for pesticides, especially herbicides. Cationic surfactants are widely known to be particularly effective bio-active enhancers for herbicides, especially for glyphosate-type herbicides. The present invention includes two novel aspects: 1) While the vast majority of COCs are petroleum-based paraffinic oils or esterified seed oils, this invention embodies a new oil phase, a hydrocarbon oil such exemplified by EXXON-MOBIL'S D-130, which when combined with the surfactants described herein, exhibits surprising enhancement of herbicidal activity in field tests; and 2) COC's are designed to form stable emulsions in water. The combination of cationic surfactants and phosphate esters in this invention not only form very stable emulsions in water, but, surprisingly, also form extremely stable emulsions in concentrated liquid fertilizers, including 32-0-0 fertilizer.
US08765626B2 Internal donor structure for olefin polymerization catalysts and methods of making and using same
The presently disclosed and claimed inventive concept(s) relates to solid catalyst components comprising titanium, magnesium, halogen and an internal electron donor compound having at least one ester group and at least one alkoxy group, and catalyst systems containing the catalyst solid components, organoaluminum compounds, and organosilicon compounds. The presently disclosed and claimed inventive concept(s) further relates to methods of making the catalyst components and the catalyst systems, and methods of polymerizing or copolymerizing alpha-olefins using the catalyst systems.
US08765622B2 Recovery of slurry unsupported catalyst
A method of recovering unsupported fine catalyst from heavy oil comprises combining a slurry comprising unsupported fine catalyst in heavy oil with solvent to form a combined slurry-solvent stream. The combined slurry-solvent stream is filtered in a deoiling zone. A stream comprising unsupported fine catalyst and solvent is recovered from the deoiling zone. Unsupported fine catalyst is separated from the stream comprising unsupported fine catalyst and solvent. Filtering in the deoiling zone can comprise filtering the slurry and solvent through a cross-flow microfiltration unit, recovering a retentate stream of the cross-flow microfiltration unit, combining the retentate stream of the cross-flow microfiltration unit with solvent to form a combined retentate-solvent stream, and filtering the combined retentate-solvent stream through a cross-flow microfiltration unit.
US08765621B2 Dielectric ceramic composition for high-frequency use and method for producing the same, as well as dielectric ceramic for high-frequency use and method for producing the same and high-frequency circuit element using the same
There is provided a dielectric ceramic composition for high-frequency use represented by a composition formula of a(Sn,Ti)O2-bMg2SiO4-cMgTi2O5-dMgSiO3. In the composition formula, a, b, c and d (provided that a, b, c and d are mol %) are within the following ranges: 4≦a≦37, 34≦b≦92, 2≦c≦15 and 2≦d≦15, respectively, and a+b+c+d=100. The dielectric ceramic composition for high-frequency use has a relative permittivity ∈r of 7.5-12.0, a Qm×fo value of not less than 50000 (GHz) and an absolute value of a temperature coefficient τf of resonance frequency fo of not more than 30 ppm/° C.
US08765620B2 Refractory product having high zirconia content
A fused and cast refractory product containing, in weight percentages on the basis of the oxides and for a total of 100%: ZrO2: remainder up to 100% Hf2O: <5% SiO2: 2% to 10% 0.9%
US08765617B2 Method of manufacturing semiconductor device
A method of manufacturing a MOSFET includes the steps of preparing a substrate with an epitaxial growth layer made of silicon carbide, performing ion implantation into the substrate with the epitaxial growth layer, forming a protective film made of silicon nitride on the substrate with the epitaxial growth layer into which the ion implantation was performed, and heating the substrate with the epitaxial growth layer on which the protective film was formed to a temperature range of 1600° C. or more in an atmosphere containing gas including a nitrogen atom.
US08765614B2 Method of forming a metal pattern and method of manufacturing a display substrate including the metal pattern
A method of forming a metal pattern on a display substrate includes blanket depositing a copper-based layer having a thickness between about 1,500 Å and about 5,500 Å on a base substrate, and forming a patterned photoresist layer on the copper-based layer. The copper-based layer is over-etched by an etching composition containing an oxidizing moderating agent where the over-etch factor is between about 40% and about 200% while using the patterned photoresist layer as an etch stopping layer, and where the etching composition includes ammonium persulfate between about 0.1% by weight and about 50% by weight, includes an azole-based compound between about 0.01% by weight and about 5% by weight and a remainder of water. Thus, reliability of the metal pattern and that of manufacturing a display substrate may be improved.
US08765613B2 High selectivity nitride etch process
An anisotropic silicon nitride etch provides selectivity to silicon and silicon oxide by forming a fluorohydrocarbon-containing polymer on silicon surfaces and silicon oxide surfaces. Selective fluorohydrocarbon deposition is employed to provide selectivity to non-nitride surfaces. The fluorohydrocarbon-containing polymer interacts with silicon nitride to form a volatile compound, thereby enabling etching of silicon nitride. The fluorohydrocarbon-containing polymer interacts with silicon oxide at a low reaction rate, retarding, or completely stopping, the etching of silicon oxide. The fluorohydrocarbon-containing polymer does not interact with silicon, and protects silicon from the plasma. The anisotropic silicon nitride etch can be employed to etch silicon nitride selective to silicon and silicon oxide in any dimension, including small dimensions less than 50 nm.
US08765611B2 Etching process for semiconductors
A process for etching semiconductors, such as II-VI or III-V semiconductors is provided. The method includes sputter etching the semiconductor through an etching mask using a nonreactive gas, removing the semiconductor and cleaning the chamber with a reactive gas. The etching mask includes a photoresist. Using this method, light-emitting diodes with light extracting elements or nano/micro-structures etched into the semiconductor material can be fabricated.
US08765609B2 Deposit/etch for tapered oxide
A process for fabricating a tapered field plate dielectric for high-voltage semiconductor devices is disclosed. The process may include depositing a thin layer of oxide, depositing a polysilicon hard mask, depositing a resist layer and etching a trench area, performing deep silicon trench etch, and stripping the resist layer. The process may further include repeated steps of depositing a layer of oxide and anisotropic etching of the oxide to form a tapered wall within the trench. The process may further include depositing poly and performing further processing to form the semiconductor device.
US08765603B2 Method of forming a buffer layer
Buffer layer and method of forming the buffer layer, the method including forming a high-k dielectric layer, forming a titanium nitride layer over the high-k dielectric layer, forming a silicon layer on the titanium nitride layer, annealing the silicon layer into the titanium nitride layer to form an annealed silicon layer and forming an n-metal over the high-k dielectric layer.
US08765601B2 Post deposition treatments for CVD cobalt films
Embodiments of the invention provide methods for forming materials on a substrate used for metal gate and other applications. In one embodiment, a method includes forming a cobalt stack over a barrier layer disposed on a substrate by depositing a cobalt layer during a deposition process, exposing the cobalt layer to a plasma to form a plasma-treated cobalt layer during a plasma process, and repeating the cobalt deposition process and the plasma process to form the cobalt stack containing a plurality of plasma-treated cobalt layers. The method further includes exposing the cobalt stack to an oxygen source gas to form a cobalt oxide layer from an upper portion of the cobalt stack during a surface oxidation process and heating the remaining portion of the cobalt stack to a temperature within a range from about 300° C. to about 500° C. to form a crystalline cobalt film during a thermal annealing crystallization process.
US08765599B2 Semiconductor devices having dielectric caps on contacts and related fabrication methods
Fabrication methods for semiconductor device structures are provided. One method for fabricating a semiconductor device structure involves forming a first layer of a first dielectric material overlying a doped region formed in a semiconductor substrate, forming a first conductive contact electrically connected to the doped region within the first layer, forming a dielectric cap on the first conductive contact, forming a second layer of a second dielectric material overlying the dielectric cap and a gate structure overlying the semiconductor substrate, and forming a second conductive contact electrically connected to the gate structure within the second layer.
US08765597B2 Fluorine depleted adhesion layer for metal interconnect structure
A line trough and a via cavity are formed within a dielectric layer comprising a fluorosilicate glass (FSG) layer. A fluorine depleted adhesion layer is formed within the line trough and the via cavity either by a plasma treatment that removes fluorine from exposed surfaces of the FSG layer, or by deposition of a substantially fluorine-free dielectric layer. Metal is deposited within the line trough and the via cavity to form a metal line and a metal via. The fluorine depleted adhesion layer provides enhanced adhesion to the metal line compared with prior art structures in which a metal line directly contacts a FSG layer. The enhanced adhesion of metal with an underlying dielectric layer provides higher resistance to delamination for a semiconductor package employing lead-free C4 balls on a metal interconnect structure.
US08765589B2 Semiconductor device manufacturing method
A semiconductor device manufacturing method, the method including: forming an insulation layer having a protruding portion, the insulation layer having a surface and a rising surface that protrudes upward from the surface, on a semiconductor substrate; forming a conductive layer to cover the insulation layer having the protruding portion; and removing a predetermined region of the conductive layer by patterning the predetermined region according to an etching process using microwave plasma, which uses a microwave as a plasma source, while applying bias power of 70 mW/cm2 or above on the semiconductor substrate, under a high pressure condition of 85 mTorr or above.
US08765584B2 Semiconductor device and manufacturing method therefor
A semiconductor device and a manufacturing method therefor, wherein, during lift-off, no cracks due to internal stresses occur in the compound semiconductor layer. A method for manufacturing a semiconductor device having a structure in which a semiconductor layer is bonded on a supporting substrate, including: a device region formation step of forming a device region including the semiconductor layer on a growth substrate through a lift-off layer; a columnar member formation step of forming a columnar member on the growth substrate; a bonding step of bonding the tops of the semiconductor layer and the columnar member to a supporting substrate; a lift-off step of separating the bottom face of the semiconductor layer from the growth substrate by removing the lift-off layer, and not separating the columnar member from the growth substrate; and a step of separating the columnar member from the supporting substrate.
US08765582B2 Method for extreme ultraviolet electrostatic chuck with reduced clamp effect
The present disclosure provides one embodiment of a semiconductor structure. The semiconductor structure includes a semiconductor substrate having a front surface and a backside surface; integrated circuit features formed on the front surface of the semiconductor substrate; and a polycrystalline silicon layer disposed on the backside surface of the semiconductor substrate.
US08765581B2 Self-aligned cross-point phase change memory-switch array
Subject matter disclosed herein relates to a memory device, and more particularly to a self-aligned cross-point phase change memory-switch array and methods of fabricating same.
US08765579B2 Semiconductor wafer processing method
A semiconductor wafer has a device area where a plurality of semiconductor devices are respectively formed in a plurality of regions partitioned by a plurality of crossing division lines formed on the front side of the semiconductor wafer and a peripheral area surrounding the device area. The back side of the semiconductor wafer corresponding to the device area is ground to thereby form a circular recess and an annular projection surrounding the circular recess. In a chip stacked wafer forming step, a plurality of semiconductor device chips are provided on the bottom surface of the circular recess of the semiconductor wafer at the positions respectively corresponding to the semiconductor devices of the semiconductor wafer. The chip stacked wafer is ground to reduce the thickness of each semiconductor device chip to a finished thickness, and a through electrode is formed in each semiconductor device of the semiconductor wafer.
US08765577B2 Defect free strained silicon on insulator (SSOI) substrates
A method of forming a strained semiconductor material that in one embodiment includes forming a cleave layer in a host semiconductor substrate, and contacting a strain inducing material layer on a surface of a transfer portion of the host semiconductor substrate. A handle substrate is then contacted to an exposed surface of the stress inducing material layer. The transfer portion of the host semiconductor substrate may then be separated from the host semiconductor substrate along the cleave layer. A dielectric layer is formed directly on the transfer portion of the host semiconductor substrate. The handle substrate and the stress inducing material are then removed, wherein the transferred portion of the host semiconductor substrate provides a strained semiconductor layer that is in direct contact with a dielectric layer.
US08765576B2 Process for producing laminated substrate and laminated substrate
A method of manufacturing a laminated substrate is provided. The method includes: forming an oxide film on at least a surface of a first substrate having a hardness of equal to or more than 150 GPa in Young's modulus, and then smoothing the oxide film; implanting hydrogen ions or rare gas ions, or mixed gas ions thereof from a surface of a second substrate to form an ion-implanted layer inside the substrate, laminating the first substrate and the second substrate through at least the oxide film, and then detaching the second substrate in the ion-implanted layer to form a laminated substrate; heat-treating the laminated substrate and diffusing outwardly the oxide film.
US08765574B2 Dry etch process
A method for conformal dry etch of a liner material in a high aspect ratio trench is achieved by depositing or forming an inhomogeneous passivation layer which is thicker near the opening of a trench but thinner deep within the trench. The method described herein use a selective etch following formation of the inhomogeneous passivation layer. The selective etch etches liner material faster than the passivation material. The inhomogeneous passivation layer suppresses the etch rate of the selective etch near the top of the trench (where it would otherwise be fastest) and gives the etch a head start deeper in the trench (where is would otherwise be slowest). This method may also find utility in removing bulk material uniformly from within a trench.
US08765573B2 Air gap formation
A method of forming air gaps between adjacent raised features on a substrate includes forming a carbon-containing material in a bottom region between the adjacent raised features using a flowable deposition process. The method also includes forming a silicon-containing film over the carbon-containing material using a flowable deposition process, where the silicon-containing film fills an upper region between the adjacent raised features and extends over the adjacent raised features. The method also includes curing the carbon-containing material and the silicon-containing material at an elevated temperature for a period of time to form the air gaps between the adjacent raised features.
US08765572B2 Method of fabricating semiconductor device
A method of fabricating a semiconductor device, in which an interference effect between word lines is substantially reduced or eliminated, includes forming a plurality of gate patterns on a substrate; forming a first insulating layer between the gate patterns, the first insulating layer filling a region between the gate patterns; etching the first insulating layer to remove a portion of the first insulating layer to a predetermined depth; and forming a second insulating layer on the gate patterns and the first insulating layer. A low-dielectric-constant material is formed between the gate patterns.
US08765570B2 Manufacturable high-k DRAM MIM capacitor structure
A method for forming a capacitor stack is described. In some embodiments of the present invention, a first dielectric material is formed above a first electrode material. The first electrode material is rigid and has good mechanical strength and serves as a robust frame for the capacitor stack. The first dielectric material is sufficiently thin (<2 nm) or highly doped so that it remains amorphous after subsequent anneal treatments. A second dielectric material is formed above the first dielectric material. The second dielectric material is sufficiently thick (>3 nm) or lightly doped or non-doped so that it crystallizes after subsequent anneal treatments. A second electrode material is formed adjacent to the second dielectric material. The second electrode material has a high work function and a crystal structure that serves to promote the formation of the high k-value crystal structure of the second dielectric material.
US08765569B2 Molybdenum oxide top electrode for DRAM capacitors
A metal oxide bilayer second electrode for a MIM DRAM capacitor is formed wherein the layer of the electrode that is in contact with the dielectric layer (i.e. bottom layer) has a desired composition and crystal structure. An example is crystalline MoO2 if the dielectric layer is TiO2 in the rutile phase. The other component of the bilayer (i.e. top layer) is a sub-oxide of the same material as the bottom layer. The top layer serves to protect the bottom layer from oxidation during subsequent PMA or other DRAM fabrication steps by reacting with any oxygen species before they can reach the bottom layer of the bilayer second electrode.
US08765568B2 Method of fabricating thermally controlled refractory metal resistor
A structure and method of fabricating the structure includes a semiconductor substrate having a top surface defining a horizontal direction and a plurality of interconnect levels stacked from a lowermost level proximate the top surface of the semiconductor substrate to an uppermost level furthest from the top surface. Each of the interconnect levels include vertical metal conductors physically connected to one another in a vertical direction perpendicular to the horizontal direction. The vertical conductors in the lowermost level being physically connected to the top surface of the substrate, and the vertical conductors forming a heat sink connected to the semiconductor substrate. A resistor is included in a layer immediately above the uppermost level. The vertical conductors being aligned under a downward vertical resistor footprint of the resistor, and each interconnect level further include horizontal metal conductors positioned in the horizontal direction and being connected to the vertical conductors.
US08765564B2 Methods of forming variable resistive memory devices
A method of forming a variable resistive memory device includes forming a conductive pattern that alternates with a first insulation pattern along a first direction on a substrate that is parallel with a surface of the substrate, forming a preliminary sacrificial pattern on the conductive pattern that contacts a sidewall of the first insulation pattern, etching the conductive pattern using the preliminary sacrificial pattern as an etch masks to form a preliminary bottom electrode pattern, patterning the preliminary sacrificial pattern and the preliminary bottom electrode pattern to form a sacrificial pattern and a bottom electrode pattern that each include at least two portions which are separated from each other along a second direction intersecting the first direction, and replacing the sacrificial pattern with a variable resistive pattern.
US08765562B2 Method for manufacturing silicon carbide semiconductor device
A collector layer having p type is formed on a silicon carbide substrate having n type. A drift layer having n type is formed on a top surface side of the collector layer. A body region provided on the drift layer and having p type, and an emitter region provided on the body region to be separated from the drift layer by the body region and having n type are formed. A bottom surface side of the collector layer is exposed by removing the silicon carbide substrate.
US08765552B2 Non-volatile storage having a connected source and well
A non-volatile storage device is disclosed that includes a set of connected non-volatile storage elements formed on a well, a bit line contact positioned in the well, a source line contact positioned in the well, a bit line that is connected to the bit line contact, and a source line that is connected to the source line contact and the well.
US08765550B2 N-channel erasable programmable non-volatile memory
In an embodiment of the invention, a method of fabricating a floating-gate NMOSFET (n-type metal-oxide semiconductor field-effect transistor) is disclosed. A silicide blocking layer (e.g. oxide, nitride) is used not only to block areas from being silicided but to also form an insulator on top of a poly-silicon gate. The insulator along with a top electrode (control gate) forms a capacitor on top of the poly-silicon gate. The poly-silicon gate also serves as the bottom electrode of the capacitor. The capacitor can then be used to capacitively couple charge to the poly-silicon gate. Because the poly-silicon gate is surrounded by insulating material, the charge coupled to the poly-silicon gate may be stored for a long period of time after a programming operation.
US08765546B1 Method for fabricating fin-shaped field-effect transistor
A method for fabricating fin-shaped field-effect transistor (FinFET) is disclosed. The method includes the steps of: providing a substrate; forming a fin-shaped structure on the substrate; forming a first gate structure on the fin-shaped structure; forming a first epitaxial layer in the fin-shaped structure adjacent to the first gate structure; forming an interlayer dielectric layer on the first gate structure and the first epitaxial layer; forming an opening in the interlayer dielectric layer to expose the first epitaxial layer; forming a silicon cap on the first epitaxial layer; and forming a contact plug in the opening.
US08765545B2 Method of manufacturing a semiconductor device
A method of manufacturing a semiconductor device is disclosed. The exemplary method includes providing a substrate having a source region and a drain region. The method further includes forming a first recess in the substrate within the source region and a second recess in the substrate within the drain region. The first recess has a first plurality of surfaces and the second recess has a second plurality of surfaces. The method also includes epi-growing a semiconductor material in the first and second recesses and, thereafter, forming shallow isolation (STI) features in the substrate.
US08765540B2 Semiconductor structure and method for manufacturing the same
The present invention provides a semiconductor structure, which comprises: a substrate, a semiconductor base, a semiconductor auxiliary base layer, a cavity, a gate stack, a sidewall spacer, and a source/drain region, wherein the gate stack is located on the semiconductor base; the sidewall spacer is located on the sidewalls of the gate stack; the source/drain region is embedded in the semiconductor base and is located on both sides of the gate stack; the cavity is embedded in the substrate; the semiconductor base is suspended above the cavity, the thickness of the middle portion of the semiconductor base is greater than the thickness of the two end portions of the semiconductor base in the direction of the length of the gate, and the two end portions of the semiconductor base are connected to the substrate in the direction of the width of the gate; and the semiconductor auxiliary base layer is located on the sidewall of the semiconductor base and has an opposite doping type to that of the source/drain region, and the doping concentration of the semiconductor auxiliary base layer is higher than that of the semiconductor base. Correspondingly, the present invention also provides a method for manufacturing a semiconductor structure. According to the present invention, the short channel effect can be suppressed, and the device performance can be improved, thereby reducing the cost and simplifying the process.
US08765535B2 Method for manufacturing a capacitor having a yttrium oxide layer
In the method for manufacturing a semiconductor device of the invention, a bonding layer is formed over a substrate, an insulating film and a storage capacitor portion lower electrode are formed over the bonding layer, a single crystal silicon layer is formed over the insulating film, a storage capacitor portion insulating film is formed over the storage capacitor portion lower electrode, a wiring is formed over the storage capacitor portion insulating film, a channel forming region and a low concentration impurity region are formed over the single crystal silicon layer, and a gate insulating film and a gate electrode are formed over the single crystal silicon layer. The storage capacitor portion insulating film is formed by depositing a YSZ film with a single crystal silicon layer used as a base film, whereby the permittivity increases and thus the leakage current from the storage capacitor portion is suppressed.
US08765532B2 Fabrication of field effect devices using spacers
A method for forming a field effect device includes forming a gate portion on a silicon-on-insulator layer (SOI), forming first spacer members on the SOI layer adjacent to the gate portion, depositing a layer of spacer material on the SOI layer, the first spacer members, and the gate portion, removing portions of the layer of spacer material to form second spacer members on the SOI layer adjacent to the first spacer members, forming a source region and a drain region on the SOI layer by implanting ions in the SOI layer, and etching to remove the second spacer members.
US08765524B2 Method and system for transient voltage suppressors
A method of forming a silicon carbide transient voltage suppressor (TVS) assembly and a system for a transient voltage suppressor (TVS) assembly are provided. The TVS assembly includes a semiconductor die in a mesa structure that includes a first layer of a first wide band gap semiconductor having a conductivity of a first polarity, a second layer of the first or a second wide band gap semiconductor having a conductivity of a second polarity coupled in electrical contact with the first layer wherein the second polarity is different than the first polarity. The TVS assembly also includes a third layer of the first, the second, or a third wide band gap semiconductor having a conductivity of the first polarity coupled in electrical contact with the second layer. The layer having a conductivity of the second polarity is lightly doped relative to the layers having a conductivity of the first polarity.
US08765522B2 Stacked oxide material, semiconductor device, and method for manufacturing the semiconductor device
One embodiment is a method for manufacturing a stacked oxide material, including the steps of forming a first oxide component over a base component, causing crystal growth which proceeds from a surface toward an inside of the first oxide component by first heat treatment to form a first oxide crystal component at least partly in contact with the base component, forming a second oxide component over the first oxide crystal component; and causing crystal growth by second heat treatment using the first oxide crystal component as a seed to form a second oxide crystal component.
US08765519B2 Methods of forming phase change materials and methods of forming phase change memory circuitry
A method of forming a phase change material which having germanium and tellurium therein includes depositing a germanium-containing material over a substrate. Such material includes elemental-form germanium. A gaseous tellurium-comprising precursor is flowed to the germanium-comprising material and tellurium is removed from the gaseous precursor to react with the elemental-form germanium in the germanium-comprising material to form a germanium and tellurium-comprising compound of a phase change material over the substrate. Other implementations are disclosed.
US08765515B2 Solid state imaging device, method of manufacturing the same, and imaging apparatus
A solid state imaging device including: a plurality of sensor sections formed in a semiconductor substrate in order to convert incident light into an electric signal; a peripheral circuit section formed in the semiconductor substrate so as to be positioned beside the sensor sections; and a layer having negative fixed electric charges that is formed on a light incidence side of the sensor sections in order to form a hole accumulation layer on light receiving surfaces of the sensor sections.
US08765512B2 Packaging compatible wafer level capping of MEMS devices
This invention discloses and claims a cost-effective, wafer-level package process for microelectromechanical devices (MEMS). Specifically, the movable part of MEMS device is encapsulated and protected while in wafer form so that commodity, lead-frame packaging can be used. An overcoat polymer, such as, epoxycyclohexyl polyhedral oligomeric silsesquioxanes (EPOSS) has been used as a mask material to pattern the sacrificial polymer as well as overcoat the air-cavity. The resulting air-cavities are clean, debris-free, and robust. The cavities have substantial strength to withstand molding pressures during lead-frame packaging of the MEMS devices. A wide range of cavities from 20 μm×400 μm to 300 μm×400 μm have been fabricated and shown to be mechanically stable. These could potentially house MEMS devices over a wide range of sizes. The strength of the cavities has been investigated using nano-indentation and modeled using analytical and finite element techniques. Capacitive resonators packaged using this protocol have shown clean sensing electrodes and good functionality.
US08765511B2 Semiconductor device and method for manufacturing the same
A method for manufacturing a semiconductor device including at least one of the following steps: (1) Forming a lower electrode pattern on/over a substrate. (2) Forming a first interlayer insulating layer on the lower electrode pattern. (3) Forming an upper electrode pattern on the first interlayer insulating layer. (4) Forming a passivation layer on a side of the upper electrode pattern. (5) Forming a second interlayer insulating layer on the upper electrode pattern. (6) Etching the second interlayer insulating layer to form a cavity which exposes the passivation layer. (7) Forming a contact ball in the cavity.
US08765510B2 Semiconductor diodes fabricated by aspect ratio trapping with coalesced films
A photonic device comprises a substrate and a dielectric material including two or more openings that expose a portion of the substrate, the two or more openings each having an aspect ratio of at least 1. A bottom diode material comprising a compound semiconductor material that is lattice mismatched to the substrate occupies the two or more openings and is coalesced above the two or more openings to form the bottom diode region. The device further includes a top diode material and an active diode region between the top and bottom diode materials.
US08765502B2 Germanium photodetector schottky contact for integration with CMOS and Si nanophotonics
A method of forming an integrated photonic semiconductor structure having a photodetector device and a CMOS device may include depositing a dielectric stack over the photodetector device such that the dielectric stack encapsulates the photodetector. An opening is etched into the dielectric stack down to an upper surface of a region of an active area of the photodetector. A first metal layer is deposited directly onto the upper surface of the region of the active area via the opening such that the first metal layer may cover the region of the active area. Within the same mask level, a plurality of contacts including a second metal layer are located on the first metal layer and on the CMOS device. The first metal layer isolates the active area from the occurrence of metal intermixing between the second metal layer and the active area of the photodetector.
US08765501B2 Formation of group III-V material layers on patterned substrates
Methods of epitaxy of gallium nitride, and other such related films, and light emitting diodes on patterned sapphire substrates, and other such related substrates, are described.
US08765500B2 Method and apparatus for fabricating phosphor-coated LED dies
The present disclosure involves a method of packaging a light-emitting diode (LED). According to the method, a group of metal pads and a group of LEDs are provided. The group of LEDs is attached to the group of metal pads, for example through a bonding process. After the LEDs are attached to the metal pads, each LED is spaced apart from adjacent LEDs. Also according to the method, a phosphor film is coated around the group of LEDs collectively. The phosphor film is coated on top and side surfaces of each LED and between adjacent LEDs. A dicing process is then performed to slice through portions of the phosphor film located between adjacent LEDs. The dicing process divides the group of LEDs into a plurality of individual phosphor-coated LEDs.
US08765499B2 Method for manufacturing LED package
A method for manufacturing an LED package includes following steps. A plate is provided. The plate defines a plurality of the through holes extending from an upper surface to a bottom surface of the plate. A blue film is attached to the bottom surface of the plate and covers openings of the through holes. The blue film and an inner wall of the plate defining the through hole cooperatively define a groove. Glue doped with phosphor particle is injected into the groove. The phosphor particles are condensed to a bottom surface of the glue adjacent to the blue film. The LED chips are embedded in the grooves and positioned at upper ends of the grooves. Finally, the blue film is removed and the plate is severed to obtain a plurality of individual LED packages each including a corresponding LED chip.
US08765494B2 Method for fabricating organic EL device and method for evaluating organic EL device
An organic EL device (OELD) having a defective portion is irradiated with a laser beam; first luminance of light emitted from the OELD is measured after the OELD is irradiated with the laser beam, while supplying, to the OELD, a first amount of current with which the OELD in a normal state would emit light having luminance corresponding to a first grayscale level smaller than a reference level; the OELD is re-irradiated with the laser beam when the first luminance is smaller than a threshold; and second luminance of light emitted from the OELD is measured when the first luminance is greater than or equal to the threshold, while supplying, to the OELD, a second amount of current with which the OELD in the normal state would emit light having luminance corresponding to a second grayscale level greater than or equal to the reference level.
US08765491B2 Shallow trench isolation recess repair using spacer formation process
A method of forming a semiconductor device includes forming a spacer layer over a plurality of transistor gate structures, the transistor gate structures being formed over both active and shallow trench isolation (STI) regions of a substrate. The spacer layer is subjected to a directional etch so as to form sidewall spacers adjacent the plurality of transistor gate structures, and a horizontal fill portion of the spacer layer remains in one more recesses present in the STI regions so as to substantially planarize the STI region prior to subsequent material deposition thereon.
US08765489B2 Semiconductor device and method for fabricating the same
A method for fabricating a semiconductor device includes forming a magnetic tunnel junction (MTJ) element on a substrate, forming a first capping layer along the shape of the MTJ element, forming an insulating layer on the first capping layer, forming a trench exposing a portion of the first capping layer above the MTJ element by selectively etching the insulating layer, forming a second capping layer on sidewalls of the trench, removing the exposed portion of the first capping layer using the second capping layer as an etching mask to expose an upper surface of the MTJ element, and forming a conductive layer in the trench, wherein the conductive layer contacts the upper surface of the MTJ element.
US08765488B2 Sensors employing single-walled carbon nanotubes
Sensing compositions, sensing element, sensing systems and sensing devices for the detection and/or quantitation of one or more analytes, Compositions comprising carbon nanotubes in which the carbon nanotubes retain their ability to luminesce and in which that luminescence is rendered selectively sensitive to the presence of an analyte. Compositions comprising individually dispersed carbon nanotubes, which are electronically isolated from other carbon nanotubes, yet which are associated with chemical selective species, such as polymers, particularly biological polymers, for example proteins, which can interact selectively with, or more specifically selectivity bind to, an analyte of interest. Chemically selective species bind, preferably non-covalently, to the carbon nanotube and function to provide for analyte selectivity. Chemically selective species include polymers to which one or more chemically selective groups are covalently attached. Chemically selective polymers include, for example, proteins and polysaccharides.
US08765486B2 Methods and systems for controlling liquids in multiplex assays
A fluidic device for conveying liquid to a well of a microplate. The device includes a support structure configured to be mounted along the microplate. The device also includes a microfluidic tube coupled to the support structure. The tube has an inlet, an outlet, and an open-sided channel that extends longitudinally therebetween. The tube has a cross-section that includes an interior contour with a gap therein. The gap extends at least partially along a length of the tube. The tube is configured to convey liquid to the well of the microplate when the tube is held in a dispensing orientation.
US08765485B2 Electronic control of fluidic species
Various aspects of the present invention relates to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an intervening fluid, etc. The invention also relates to systems and methods for fusing droplets according to another aspect of the invention, for example, through charge and/or dipole interactions. In some cases, the fusion of the droplets may initiate or determine a reaction. In still another aspect, the invention relates to systems and methods for sorting droplets, e.g., by causing droplets to move to certain regions within a fluidic system. Examples include using electrical interactions (e.g., charges, dipoles, etc.) or mechanical systems (e.g., fluid displacement) to sort the droplets.
US08765477B2 Hot-spot temperature measurment in an oil containing electric apparatus with a compound forming a temperature dependent oil soluble residue
A method for measuring the real hot-spot temperature in an electric apparatus containing an oil, such as an electric power transformer. The electric apparatus is operated under predetermined and modifiable operating conditions. This method comprises the use of one or several chemical compounds or tracers present and soluble in the oil. Each tracer may transform, at a given temperature, in order to form a residue, such as a soluble gas. From the presence of the residue in the oil, the operator will be able to determine under which predetermined operating condition the hot-spot has been reached and to deduce the hot-spot for a given condition. Among different used compounds, there are diazoic compounds, carbonyl metals, colorants, pigments, liquid crystals and albumins. The method also allows to check the quality of the apparatus on the market and to estimate its life span.
US08765475B2 Colorimetric absorbance measurement method, apparatus and system
Various embodiments disclose a colorimetric absorbance measurement method and a system for performing the same. The method comprises driving a reaction tray carrying a plurality of reaction cuvettes to rotate at a speed; transferring or rotating filters on a filter wheel to a light path of a light beam, starting from a filter of a first wavelength; and sampling photoelectric data when the light beam has passed through each reaction cuvette in some embodiments. The method ensures consistency in the measurement and synchronization between the calibration and the sample test and reliability of the measurements. Various embodiments simplify data processing and reduce the complexity of the system.
US08765473B2 Method of preparing basement membrane, method of constructing basement membrane specimen, reconstituted artificial tissue using the basement membrane specimen and process for producing the same
A basement membrane having a barrier function is formed by culturing alveolar epithelial cells or vascular endothelial cells on a fibrous collagen matrix coated with a polymer having a sugar chain that can localize a receptor that has an activity to accumulate a basement membrane component on the basal surface of the cells having an ability to form a basement membrane. A reconstructed artificial tissue is obtained by seeding and culturing desired homogeneous or heterogeneous cells on the basement membrane specimen constructed by the following process: (i) the cells having an ability to form a basement membrane adhered onto a support structure through a basement membrane are treated with a surface active agent; (ii) the lipid component of cells is lysed; (iii) the mixture of an alkaline solution and a protease inhibitor is used to lyse the protein remained on the surface of the basement membrane of the cells.
US08765472B2 Methods and device to constrain multicellular arrangements in stable, stationary and reproducible spatial configuration
The present invention relates to methods and devices to obtain multicellular arrangements in stable, stationary and reproducible spatial configuration, and optionally with controlled internal cell organization, methods for preparing such devices, methods for studying the cells' shapes, the cells' architectures, the cells' mechanical equilibrium, the cell-cell interaction, the cell movement and migration, the cell differentiation, the global internal cells' organizations, the cells' polarities and division, and/or any function of cells, methods for screening compounds of interest which enhance or inhibit specific cell functions.
US08765467B2 Multicellular compositions of pluripotent human embryonic stem cells and cancer cells
Methods are provided for producing novel multicellular compositions comprising cancer cells together with pluripotent human stem cells, which are capable of proliferating and differentiating into various normal cell lines and tissue structures. These novel multicellular compositions are useful for investigating the properties of cancer cells in a normal human tissue microenvironment, and for studying interventions that will modulate these properties including devising, testing and screening therapeutic drugs.
US08765466B2 Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.
US08765455B2 Chip-based droplet sorting
A non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device based on the droplet's contents and their interaction with an applied electromagnetic field or by identification and sorting.
US08765451B2 Method of treating an off-gas stream and an apparatus therefor
The present invention provides a method of treating an off-gas stream (80) comprising NH3 and H2S to provide a sulphate stream (910), the method comprising the steps of: (i) providing a first off-gas stream (80) comprising NH3, H2S, CO2 and optionally one or more of HCN, COS and CS2; (ii) passing the first off-gas stream (80) to an incinerator (300) to oxidize NH3, H2S, and optionally one or more of HCN, COS and CS2 to provide a second off-gas stream (310) comprising N2, H2O, SO2 and CO2; (iii) scrubbing the second off-gas stream (310) with a first aqueous alkaline stream (380, 876a) in a caustic scrubber (350) to separate SO2 and a part of the CO2 from the second off-gas stream to provide a spent caustic stream (360) comprising carbonate and one or both of sulphite and bisulphite and a caustic scrubber off-gas stream (370) comprising N2 and CO2; and (iv) passing the spent caustic stream (360) to an aerator (900) comprising sulphur-oxidizing bacteria in the presence of oxygen to biologically oxidize sulphite and bisulphite to sulphate to provide a sulphate stream (910).
US08765446B2 Recombinant mutant microorganisms having increased ability to produce alcohols and method of producing alcohols using the same
The present invention relates to recombinant mutant microorganisms having an increased ability to produce alcohol and a method of producing alcohol using the same, and more particularly to recombinant mutant microorganisms which have an increased ability to produce butanol, ethanol, isopropanol or mixed alcohols, which can be used as fuel, while producing little or no producing acetone as a byproduct, and to a method of producing butanol, ethanol, isopropanol or mixed alcohols using the same. The inventive recombinant mutant microorganisms having an increased ability to produce butanol or mixed alcohols and to remove acetone are those in which genes that encode enzymes involved in producing butanol from butyryl-CoA or butylaldehyde and in producing isopropanol from acetone were amplified or introduced in host microorganisms. The recombinant mutant microorganisms produce little or no byproducts such as acetone and can have an increased ability to produce alcohols, as a result of manipulating metabolic pathways. Thus, the recombinant mutant microorganisms are useful for industrial production of butanol or mixed alcohols comprising butanol and isopropanol.
US08765444B2 Compositions and methods using herpes simplex virus
Provided herein are methods and compositions for use in treating HSV-related conditions and diseases.
US08765442B2 Process for production of an enzyme product
The invention relates to a process for production of an enzyme product having a plurality of enzyme activities obtained by fermentation of an Aspergillus strain.
US08765439B2 Trichoderma reesei α-amylase enhances saccharification of corn starch
A maltogenic α-amylase from Trichoderma reesei (TrAA) and variants thereof in the presence of a glucoamylase are useful in the production of high-glucose syrups from liquefied starch, where the high-glucose syrups produced thereby contain at least about 97% glucose. In this process, TrAA advantageously suppresses the reversion of glucose to malto-oligosaccharides. Expression hosts and encoding nucleic acids useful for producing TrAA and its variants also are provided.
US08765433B2 Alcohol dehydrogenases (ADH) useful for fermentive production of lower alkyl alcohols
The invention relates to suitable candidate alcohol dehydrogenase (ADH) enzymes for production of lower alkyl alcohols including isobutanol. The invention also relates to recombinant host cells that comprise such ADH enzymes and methods for producing lower alkyl alcohols in the same.
US08765432B2 Targeted drug phosphorylcholine polymer conjugates
The present invention provides random copolymers containing phosphorylcholine and one or more functional agents, and methods of preparing such random copolymers.
US08765429B2 Biomass shock pretreatment
Methods and apparatus for treating biomass that may include introducing a biomass to a chamber; exposing the biomass in the chamber to a shock event to produce a shocked biomass; and transferring the shocked biomass from the chamber. In some aspects, the method may include pretreating the biomass with a chemical before introducing the biomass to the chamber and/or after transferring shocked biomass from the chamber.
US08765424B2 Tailored oils produced from recombinant heterotrophic microorganisms
Methods and compositions for the production of oil, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants.
US08765410B2 Methods and compositions for improving sugar transport, mixed sugar fermentation, and production of biofuels
The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods of co-fermenting cellulose-derived and hemicellulose-derived sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports a pentose into the cell, methods of increasing transport of a pentose into a cell, methods of increasing growth of a cell on a medium containing pentose sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports a pentose into the cell.
US08765409B2 Efficient production of heterologous proteins using mannosyl transferase inhibitors
Compounds and methods are described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of certain benzylidene thiazolidinediones inhibitors of Pmt-mediated O-linked glycosylation.
US08765408B2 Prophage element-free bacteria
The present invention provides a bacterium having a genome that is genetically engineered to be smaller than the genome of its native parent strain. A bacterium with a smaller genome can produce a commercial product more efficiently. The present invention also provides methods for deleting genes and other DNA sequences from a bacterial genome. The methods provide precise deletions and seldom introduces mutations to the genomic DNA sequences around the deletion sites. Thus, the methods can be used to generate a series of deletions in a bacterium without increasing the possibility of undesired homologous recombination within the genome. In addition, some of the methods provided by the present invention can also be used for replacing a region of a bacterial genome with a desired DNA sequence.
US08765400B2 Method for the detection of acid production by cariogenic bacteria
The present invention relates to a method for the semi-quantitative determination of cariogenic bacteria in a sample of saliva and/or plaque, in which the microorganisms contained in a sample of plaque or saliva are brought into contact with a carbon source that is fermented to acid by the cariogenic bacteria. The microorganisms are then incubated under conditions which make possible selective acid formation by the cariogenic bacteria. The acid formation is then detected by determining the pH at least once within a period of 12 hours after adding the carbon source, wherein the cariogenic bacteria are determined semi-quantitatively in the sample by comparison of the pH with at least one reference value. In addition, the invention provides kits for carrying out such methods.
US08765391B2 Cell assay kit and method
A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.
US08765390B2 Identification and isolation of squamous carcinoma stem cells
Squamous carcinoma stem cells (SCSC) are identified. The cells can be prospectively isolated or identified from primary tumor samples, and are shown to possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation, and to form unique histological microdomains useful in cancer diagnosis.
US08765389B2 Genetic products which are differentially expressed in tumors and use thereof
The invention relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for said products. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors and to the coding nucleic acids for said proteins, polypeptides and peptides.
US08765380B2 Bead emulsion nucleic acid amplification
Disclosed are methods for nucleic acid amplification wherein nucleic acid templates, beads, and amplification reaction solution are emulsified and the nucleic acid templates are amplified to provide clonal copies of the nucleic acid templates attached to the beads. Also disclosed are kits and apparatuses for performing the methods of the invention.
US08765377B2 Compositions and methods for treating and preventing coronary heart disease
The invention pertains to a method of determining a statin dosage for an individual in need of treatment with a statin, comprising determining a SLCO1B1 genotype from a nucleic acid sample of the individual, said genotype comprising the presence or absence of the SLCO1B1-056 polymorphism, and determining an ApoE genotype or phenotype identifying an ApoE polymorphism selected from the group consisting of ApoE2, ApoE3, ApoE4, and any combination thereof, wherein the combination of a SLCO1B1 genotype identifying the presence of the SLCO1B1-056 C polymorphism and the ApoE genotype or phenotype identifying one of the ApoE3/4 or ApoE4/4 genotypes indicates the statin dosage.
US08765373B2 Sensor and method for detection of a target substance
A method of detecting a target substance includes providing a number of molecular tethers at a channel surface of a sensor such that at least some of a plurality of beads, as a result of a biological interaction between a target substance and the tethers, are attached to the channel surface by the tethers or released from the channel's surface by cleaving the tethers. This method further includes introducing an analyte into the channel and determining the population of beads at the channel surface to indicate a presence of the target substance in the analyte.
US08765370B2 Inhibition-based high-throughput screen strategy for cell clones
A method for screening cells with high level expression of a target protein is disclosed. The method includes introducing into a plurality of host cells a DNA construct that encodes both a target protein and an inhibitor to an endogenous selectable marker in the host cells, screening host cells harboring the DNA construct for the expression of the endogenous selectable marker, and isolating cells with reduced expression of the selectable marker. Also disclosed is a DNA construct configured to express both the target protein and the inhibitor inside the host cell.
US08765369B2 Ultrasensitive detection of target using target-ready particles
The invention relates to methods and reagents for detecting minute amounts of targets having affinity for nucleic acid. The present invention more particularly relates to target detection using aggregates of cationic polymer chains and nucleic acid capture probes linked to particles, such as controllable mobility particles.
US08765367B2 Methods and instruments for processing a sample in a multi-chambered receptacle
A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.
US08765360B2 Optical films and methods of making the same
Films for optical use, articles containing such films, methods for making such films, and systems that utilize such films, are disclosed.
US08765359B2 Method of fabricating patterned functional substrates
Methods of preparing organosilane-functionalized regions on a substrate surface and more specifically fabricating patterned functionalized substrates suitable to be optically read, the methods generally comprising employing a vapor deposition process of an organosilane gas onto a lithographically patterned silicon surface followed by removal of the patterning media in a bath of organic solvents and ultrasonic excitation. The inventive methods provide optimized surface density of functional species while avoiding deleterious effects that can occur when lithographically patterned substrates are exposed to various gaseous species during the functionalization process.
US08765358B2 Water-soluble resin composition and method of forming fine patterns by using the same
A water-soluble resin composition for forming fine patterns comprising water-soluble polymer represented by Chemical Formula 1 as below and the first water-soluble solvent, is coated and heated on a photoresist layer having at least one contact hole to reduce a size of the at least one contact hole. (In Chemical Formula 1, each of R1, R2, R3 and R5 independently represents an alkyl group of C1-30 or an cyclo alkyl group of C3-30 which respectively have one selected from the group consisting of hydrogen, an ether group, an ester group, a carbonyl group, an acetal, an epoxy group, a nitril group, an amine group, and an aldehyde group; each of R4, R6, R7 and R8 independently represents hydrogen or a methyl group; n represents an integer of 0 to 5; a represents a real number of 0.05 to 0.5; each of b, c and d respectively represents a real number of 0 to 0.7; and a+b+c+d=1).
US08765357B2 Resin and photoresist composition comprising same
The present invention provides a resin comprising a structural unit derived from a compound represented by the formula (I): wherein R1 represents a hydrogen atom or a methyl group, A2 represents a divalent fluorine-containing C1-C12 hydrocarbon group, and A1 represents a group represented by the formula (a-g1): A10-X10sA11-  (a-g1) wherein A10 is independently in each occurrence a C1-C5 aliphatic hydrocarbon group, A11 represents a C1-C5 aliphatic hydrocarbon group, X10 is independently in each occurrence —O—, —CO—, —CO—O— or —O—CO—, and s represents an integer of 0 to 2, and a photoresist composition comprising the resin and an acid generator.
US08765356B2 Calixarene compound and photoresist composition comprising same
A molecular glass compound includes (A) a tetrameric reaction product of a specific aromatic compound having at least one hydroxy group, and a specific polycyclic or fused polycyclic aromatic aldehyde; and (B) an acid-removable protecting group as an adduct with the hydroxy group of the aromatic compound and/or a hydroxy group of the polycyclic or fused polycyclic aromatic aldehyde. A photoresist composition including the molecular glass compound, and a coated substrate including a layer of the photoresist composition are also disclosed.
US08765354B2 Resist composition for negative development and method of forming resist pattern
A resist composition for negative development including a base component (A) which exhibits decreased solubility in an organic solvent under the action of acid and an acid generator component (B) which generates acid upon exposure; and the resist composition used in a method of forming a resist pattern which includes: forming a resist film on a substrate using the resist composition; conducting exposure of the resist film; and patterning the resist film by negative development using a developing solution containing the organic solvent to form a resist pattern, wherein the acid generator component (B) contains an acid generator (B1) that generates an acid having a log P value of 2.7 or less and also a pKa value of at least −3.5.
US08765351B2 Salt and photoresist composition containing the same
A salt represented by the formula (X): wherein Q1 and Q2 each independently represent a fluorine atom or a C1-C6 perfluoroalkyl group, L1 represents a C1-C17 divalent saturated hydrocarbon group in which one or more —CH2— can be replaced by —O— or —CO—, ring W1 represents a C4-C36 lactone ring, R3 is a C1-C6 alkyl group etc., t represents an integer of 0 to 2, Z+ represents an organic counter ion, and W10 represents a group represented by the formula (X-1): wherein L2 represents a single bond etc., ring W2 represents a C3-C36 saturated hydrocarbon ring in which one —CH2— is replaced by —CO— and in which one or more —CH2— can be replaced by —O— or —CO—, R1 represents a C1-C12 hydrocarbon group, R2 is a C1-C6 alkyl group etc., and s represents an integer of 0 to 2, or a group represented by the formula (X-2): wherein L3 represents a C1-C17 divalent saturated hydrocarbon group in which one or more —CH2— can be replaced by —O— or —CO—, ring W3 represents a C3-C36 saturated hydrocarbon ring, R4 is a hydroxyl group etc., R5 is a C1-C6 alkyl group etc., v represents an integer of 1 to 3, and w represents an integer of 0 to 2.
US08765350B2 Method of manufacturing toner carrier, device for manufacturing toner carrier, toner carrier, development agent, and process cartridge
A method of manufacturing toner carrier formed of a core and a cover thereon, including the steps of: coating the core with a liquid cover containing a solvent and a material for forming the cover on the core in a processing tank; heating the core and the cover by first microwave radiation to volatilize the solvent from the cover; and removing the solvent volatilized in the step of heating from the processing tank.
US08765344B2 Electrophotographic toner and method of preparing the same
An electrophotographic toner and a method of preparing the same, the electrophotographic toner including a binder that includes two kinds of resin having different weight average molecular weights, a colorant, and a releasing agent.
US08765342B2 Photoconductors
A photoconductor containing an optional anticurl layer, a supporting substrate, an optional ground plane layer, an optional hole blocking layer, an optional adhesive layer, a photogenerating layer, a charge transport layer, and an overcoat layer mixture of a charge transport compound, a melamine resin, an optional acid catalyst, and a fluoro component.
US08765339B2 Imaging member layers
The presently disclosed embodiments relate generally to layers that are useful in imaging apparatus members and components, for use in electrophotographic, including digital printing, apparatuses. More particularly, the embodiments pertain to an improved electrophotographic imaging member comprising a charge transport layer comprising a novel combination of a tetraaryl polycarbonate copolymer binder and perfluorinated fillers. The present charge transport layer provides reduced wear rate and long service life.
US08765330B2 Phase shift mask for extreme ultraviolet lithography and method of fabricating same
A mask and method of fabricating same are disclosed. In an example, a mask includes a substrate, a reflective multilayer coating disposed over the substrate, an Ag2O absorber layer disposed over the reflective multilayer coating, and a tantalum-containing absorber layer disposed over the Ag2O absorber layer. The tantalum-containing absorber layer is disposed over the Ag2O absorber layer outside a mask image region of the mask, such that the mask image region of the mask is free of the tantalum-containing absorber layer. In an example, the tantalum-containing absorber layer is disposed over the Ag2O absorber layer adjacent to the mask image region.
US08765329B2 Sub-resolution rod in the transition region
The present disclosure provides a photomask. The photomask includes a first integrated circuit (IC) feature formed on a substrate; and a second IC feature formed on the substrate and configured proximate to the first IC feature. The first and second IC features define a dense pattern having a first pattern density. The second IC feature is further extended from the dense pattern, forming an isolated pattern having a second pattern density less than the first pattern density. A transition region is defined from the dense pattern to the isolated pattern. The photomask further includes a sub-resolution rod (SRR) formed on the substrate, disposed in the transition region, and connected with the first IC feature.
US08765328B2 Exposure mask and method for manufacturing same and method for manufacturing semiconductor device
An exposure mask used to transfer a pattern defined by exposure onto a wafer, includes: a substrate; a pattern formation region provided on the substrate, and having pattern elements formed therein, the pattern elements having a size not smaller than a resolution limit after being transferred onto the wafer; and a sub-pattern formation region provided on the substrate and having sub-pattern elements formed therein. The sub-pattern element has a size smaller than the resolution limit after being transferred onto the wafer, and the sub-pattern formation region is spaced from the pattern formation region by a distance having no optical proximity effect on the pattern.
US08765327B2 Fuel cell electrodes with conduction networks
A fuel cell electrode layer may include a catalyst, an electronic conductor, and an ionic conductor. Within the electrode layer are a plurality of electronic conductor rich networks and a plurality of ionic conductor rich networks that are interspersed with the electronic conductor rich networks. A volume ratio of the ionic conductor to the electronic conductor is greater in the ionic conductor rich networks than in the electronic conductor rich networks. During operation of a fuel cell that includes the electrode layer, conduction of electrons occurs predominantly within the electronic conductor rich networks and conduction of ions occurs predominantly within the ionic conductor rich networks.
US08765326B2 Joining device for fuel cell stack and fuel cell stack provided with the same
The present invention features a fuel cell stack that preferably includes an electricity generating assembly having a plurality of unit cells that are suitably disposed one after another; a pair of end plates pressedly disposed respectively at upper and lower ends of the electricity generating assembly; and a joining device suitably engaging the end plates by a rope, where pressure is applied to the electricity generating assembly by means of tension of the rope, and the length and tension of the rope is suitably controlled.
US08765316B2 Fuel cell system
A fuel cell system includes a fuel cell, an operation controller and an air-conditioning mechanism. In response to a heating request for the air-conditioning mechanism during ordinary operation where the fuel cell is operated at an operating point on a current-voltage characteristic curve of the fuel cell, the operation controller compares a heat value-based required current value with an output-based required current value. When the output-based required current value is equal to or greater than the heat value-based required current value, the operation controller causes the fuel cell to be operated at an operating point on the current-voltage characteristic curve. When the output-based required current value is smaller than the heat value-based required current value, the operation controller controls the operating point of the fuel cell to an operating point of lower power generation efficiency than that of the operating point on the current-voltage characteristic curve.
US08765311B2 Fuel cell
A fuel cell (1) includes an electromotive unit (2) having a membrane electrode assembly (MEA) (12), a fuel storage unit (4) storing a liquid fuel, and a fuel supply mechanism (3) supplying the fuel from the fuel storage unit (4) to a fuel electrode (7) of the membrane electrode assembly (12). The membrane electrode assembly (12) has a gas vent hole (17) provided in a manner to penetrate through at least an electrolyte membrane (11) to let a gas component generated on a side of the fuel electrode (7) escape to a side of an air electrode (10).
US08765309B2 Electrochemical device
Disclosed is an electrochemical device comprising a pair of electrodes and provided therebetween, a gelled nonaqueous electrolyte composition containing an electrolyte and a gelling agent having two or more amide groups in the chemical structure.
US08765308B2 Porous membrane and process for preparing the same
The present invention relates to a porous membrane containing cellulose fibers, wherein the cellulose fibers contain 5% by weight or more of cellulose fibers with a diameter of 1 μm or more, relative to the total weight of the cellulose fibers, the mode diameter (maximal frequency) of the pore distribution determined by the mercury penetration method is less than 0.3 μm, the air resistance per thickness of 10 μm is from 20 to 600 seconds, and the porous membrane has a volume resistivity of 1500 Ω·cm or less determined by alternate current with a frequency of 20 kHz in which the porous membrane is impregnated with 1 mol/LiPF6/propylene carbonate solution. The porous membrane according to the present invention can provide a separator for electrochemical devices with superior properties at a reasonable cost.
US08765303B2 Lithium-ion cell having a high energy density and high power density
A lithium-ion cell comprising: (A) a cathode comprising graphene as the cathode active material having a surface area to capture and store lithium thereon and wherein said graphene cathode is meso-porous having a specific surface area greater than 100 m2/g; (B) an anode comprising an anode active material for inserting and extracting lithium, wherein the anode active material is mixed with a conductive additive and/or a resin binder to form a porous electrode structure, or coated onto a current collector in a coating or thin film form; (C) a porous separator disposed between the anode and the cathode; (D) a lithium-containing electrolyte in physical contact with the two electrodes; and (E) a lithium source disposed in at least one of the two electrodes when the cell is made. This new Li-ion cell exhibits an unprecedentedly high energy density.
US08765298B2 Electrode assembly having electrode plate with cutoff portion and rechargeable battery having the same
An electrode assembly and a secondary battery having the same are disclosed. The electrode assembly includes a positive electrode plate, a negative electrode plate, and a separator. The positive electrode plate includes a positive electrode active material and a positive electrode tab. The negative electrode plate includes a negative electrode active material and a negative electrode tab. The separator is disposed between the positive electrode plate and the negative electrode plate.
US08765297B2 Advanced graphite additive for enhanced cycle-life of lead-acid batteries
An Advanced Graphite, with a lower degree of ordered carbon domains and a surface area greater than ten times that of typical battery grade graphites, is used in negative active material (NAM) of valve-regulated lead-acid (VRLA) type Spiral wound 6V/25 Ah lead-acid batteries. A significant and unexpected cycle life was achieved for the Advanced Graphite mix where the battery was able to cycle beyond 145,000 cycles above the failure voltage of 9V in a non-stop, power-assist cycle-life test. Batteries with Advanced Graphite also showed increased charge acceptance power and discharge power compared to control groups.
US08765296B2 Ionic liquid
Disclosed is an ionic liquid having a low melting point, a low viscosity, and high electrical conductivity. Specifically disclosed is an anion represented by [CF3OCF2CF2BF3]− for use in the production of such ionic liquids.
US08765295B2 Electrolyte including silane for use in electrochemical devices
The electrolyte includes one or more salts and a silane. The silane has a silicon linked to one or more first substituents that each include a poly(alkylene oxide) moiety or a cyclic carbonate moiety. The silane can be linked to four of the first substituents. Alternately, the silane can be linked to the one or more first substituents and one or more second substituents that each exclude both a poly(alkylene oxide) moiety and a cyclic carbonate moiety.
US08765292B2 Sealing body for a sealed cell, and a sealed cell using the sealing body
[Problem]There is provided a sealed cell with no possibility of liquid leakage without sacrificing volume energy density.[Measures to solve the problem]The sealing body is characterized as follows: the sealing body for a sealed cell comprises a substantially rectangular-shaped sealing plate having a through hole and/or a thinner portion that is thinner than other portions, and an electrode external terminal attached to the through hole and/or the thinner portion; and the periphery of the sealing body in the vicinity of the terminal plate is thicker than other portions. The thicker portion is 0.1 to 0.4 mm thicker than the other portions, and the width of the thicker portion is preferably 0.1 to 0.5 mm.
US08765291B2 Rechargeable battery
A rechargeable battery having increased output and capacity, and improved reliability and safety. A rechargeable battery includes: an electrode assembly including a first electrode plate including a plurality of first protrusions extending from an end of the electrode assembly and a second electrode plate including a plurality of second protrusions extending from the end of the electrode assembly, at least one of the plurality of first protrusions or the plurality of second protrusions including a planar portion and a curved portion; a case containing the electrode assembly; and a collector plate coupled to the at least one of the plurality of first protrusions or the plurality of second protrusions and covering at least the curved portion.
US08765288B2 Individual cell for a battery and method for the production thereof
An individual cell for a battery comprises an electrode stack disposed within a cell housing and a method for the production thereof. The individual electrodes, preferably electrode foils, are electrically connected to lead vanes, and at least electrodes of different polarity are separated and insulated from each other by a separator preferably a separator foil. Lead vanes of the same polarity are electrically connected to each other to form a pole. The lead vanes of a pole are electrically compressed with each other and/or welded to each other.
US08765287B2 Battery module
A battery module includes a plurality of battery cells, and at least one barrier adjoining at least one of the battery cells. The barrier includes a plurality of linear members extending in a crosswise direction across the barrier, and a set of the linear members defining a sloping open area in the form of a passage that widens toward one lateral edge of the barrier.
US08765283B2 Conductive tab and battery pack having the same
A conductive tab includes a battery connecting part contacting a plurality of secondary batteries, a wire connecting part extended from the battery connecting part and connected to a wire, and at least one bending part formed in the battery connecting part. The bending part is coupled to the secondary battery to guide the positions of the secondary batteries. The conductive tab can be exactly welded at a predetermined position of the secondary battery, and prevents conductive tabs from closely adhering to each other during a welding process.
US08765278B2 High-energy metal air batteries
Disclosed herein are embodiments of lithium/air batteries and methods of making and using the same. Certain embodiments are pouch-cell batteries encased within an oxygen-permeable membrane packaging material that is less than 2% of the total battery weight. Some embodiments include a hybrid air electrode comprising carbon and an ion insertion material, wherein the mass ratio of ion insertion material to carbon is 0.2 to 0.8. The air electrode may include hydrophobic, porous fibers. In particular embodiments, the air electrode is soaked with an electrolyte comprising one or more solvents including dimethyl ether, and the dimethyl ether subsequently is evacuated from the soaked electrode. In other embodiments, the electrolyte comprises 10-20% crown ether by weight.
US08765276B2 Common mode voltage enumeration in a battery pack
An apparatus and method for these embodiments of the present invention, useful in manufacturing for example, includes a plurality of battery modules serially intercoupled together, each module including a housing with an anode connector and a cathode connector, each housing including a memory for storing a module identifier and wherein an anode connector of a first module is coupled to a cathode connector of a second module; and a processing system, coupled to each the module, for determining a plurality of positional attributes of each the module, one positional attribute associated with each the module of the plurality of modules, the processing system writing an ID into the memory of each particular module responsive to the associated positional attribute for the particular module.
US08765271B2 Light-emitting element material, light-emitting element, electronic device, and lighting device
A light-emitting element material including an ionic iridium complex in which a 4,4′-bipyrimidine structure is coordinated to iridium is provided. Alternatively, a light-emitting element material including an ionic iridium complex represented by the following structural formula (1) is provided. In addition, a light-emitting element including the light-emitting element material is provided.
US08765270B2 Triazine compound and organic light emitting device using the same
Provided is an organic light emitting device having a long continuous driving lifetime. The organic light emitting device includes an anode, a cathode, and an organic compound layer which is sandwiched between the anode and the cathode, in which: one of the anode and the cathode is transparent or semi-transparent; and the organic compound layer contains at least one kind of triazine compound represented by the following general formula (1): ArT)n  (1) where n represents an integer of 1 or 2; Ar represents a fused polycyclic aromatic group which has three or more rings and may have a substituent; and T represents a triazine group represented by the following general formula (2): where R1 and R2 each represent a phenyl group or a phenyl group substituted by an alkyl group and may be identical to or different from each other.
US08765267B2 Composition and method for treating wood
The invention relates to a composition for treating wood comprising at least one wood preserving compound and a carrier, wherein said carrier is an emulsion or microemulsion having a water to oil ratio of greater than 30 up to 92.5 water to 7.5 to less than 70 oil, wherein the oil has a flash point above 61° C. The invention also relates to methods of treating wood with the composition.
US08765266B2 Wet friction member and its manufacturing method
A wet friction member contains a pulverized cork heated to 150-200° C. if necessary. The pulverized cork is mixed with other papermaking materials and formed into a paper-made substrate. The paper-made substrate is impregnated with a synthetic resin to be a binder and heated and cured. The cork itself has a high friction coefficient μ. Moreover, a powder thereof increases surface area and area in contact with a separator plate of a counter member, thereby improving a friction coefficient of a friction surface of the wet friction member. The friction coefficient of the cork itself and capacities for absorbing and discharging oil are improved by heating the cork. Thus, there is provided a wet friction member that has a higher friction coefficient μ. An increase in the friction coefficient μ, weight reduction by reducing the number of friction members, and high efficiency are achieved when used as a wet friction member.
US08765265B2 Polymer sliding material, artificial joint member, medical appliance, and manufacturing method therefor
Disclosed is a sliding member with excellent durability and capable of maintaining wear resistance over a long period of time. Further disclosed is an artificial joint member for which the film thickness of the polymer base material is reduced. Further disclosed is an artificial joint which is capable of demonstrating high lubricity, biocompatibility, and resistance to dislocation after introduction into the body. Further disclosed are a medical appliance material and a medical appliance which demonstrate excellent biocompatibility. The sliding material or the medical appliance material is formed by a polymer layer or a biocompatible material layer (B) being provided by coating at least a portion of the surface of a polymer base material (A), the surface of which has a ketone group, and the polymer layer or biocompatible layer (B) is characterized by being formed by surface graft polymerization, wherein the polymer base material (A) is immersed in a reaction system which contains a monomer (C), the polymer base material (A) is exposed to light, and polymerization of the monomer is initiated from the surface of the polymer base material (A). Using the sliding material or medical appliance material, an artificial joint member, an artificial joint, a medical appliance material, and a medical appliance are manufactured.
US08765255B2 Breathable waterproof garment
A garment containing a breathable laminate that is optionally bonded to an outer layer fabric and an optional inner layer fabric. The breathable laminate is constructed from a microporous membrane situated in a face to face relationship with a nanoweb and optionally bonded thereto.
US08765246B2 Stack or collection of essentially flat primary products and method for producing such a stack or such a collection
The invention relates to a stack or a collection (10) of essentially flat primary products (11-14), in particular printed products, which stack or collection (10) comprises three or more primary products (11-14) which are arranged one immediately above the other in the stack or immediately side by side in the collection and are detachably joined together, and at least one of which is a printed product which has a folded edge.Simple post-processing is achieved by adhesive areas (16) in contact respectively with both adjacent primary products being provided in order to form a detachable connection between adjacent primary products.
US08765245B2 Self adhering fabric patch
A flame retardant patch for repairing a tear or hole in clothing or gear includes a flame resistant fabric and a pressure sensitive adhesive bonded to the fabric by hot melt lamination. The pressure sensitive adhesive contains halogenated flame retardant compounds. A release paper covers the pressure sensitive adhesive and is removed to allow application of the flame retardant patch to the clothing or other item being repaired. The patch is attached by applying pressure to the top fabric surface of the patch for approximately 45 seconds using the convex surface of a spoon-like object.
US08765240B2 Molding compound comprising a polyester resin composition, film produced from the molding compound and method for producing a film or film web
The invention relates to a molding compound including a polyester resin composition, ABS components, waxes, matting agents and optionally vegetable oil, which is used to produce films with a low luster, improved thermal resistance of the film and/or of the surface structure and an increased shrinking onset temperature, in addition to a modified shrinkage progression in comparison to films without the aforementioned additives. The fraction of the polyester resin composition is between 30 and 97 wt. % and the fraction of the additives between 1.5 and 70 wt. %, in relation to the total weight of the molding compound. The films are used as shrink-wrapping and packaging films and films for furniture and printed circuit boards.
US08765237B2 Trash compactor carton with antimicrobial properties
Embodiments of the invention relate to trash compactor boxes that have an antibacterial or antimicrobial feature incorporated therein. In a general embodiment, the carton boxes have a built-in compound, such as an antimicrobial, antiseptic, and/or a biocide material.
US08765235B2 Polymerizable compound
Provided is a novel polymerizable azomethine compound which has a high Δn and is colorless.The compound is represented by the formula (I). P1 and P2 each are a polymerizable group; m1 and m2 each are an integer of from 1 to 10; R1 and R2 each are an alkyl group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, an alkoxycarbonyl group having from 2 to 5 carbon atoms, an acyloxy group having from 2 to 5 carbon atoms, an acyl group having from 2 to 4 carbon atoms, an amide group having from 2 to 5 carbon atoms, a cyano group or a halogen atom; n1 and n2 each are an integer of from 0 to 4; R3 is a hydrogen atom, or an alkyl group having from 1 to 4 carbon atoms; Z1 and L1 each are a predetermined divalent group; n is 0, 1 or 2.
US08765234B2 Electron beam plasma chamber
A method and apparatus for tailoring the formation of active species using one or more electron beams to improve gap-fill during an integrated circuit formation process is disclosed herein. The energy of the electron beams may be decreased to maximize electrons leading to radicals or increased to maximize electrons leading to ions, depending on the fill application. An apparatus comprising multiple impinging jets of gas perpendicular to one or more electron beams is also disclosed.
US08765228B2 Method of mitigating ice build-up on a substrate
The present invention is directed to a method of mitigating ice build-up on a substrate, such as a wind blade, comprising applying to the substrate curable film-forming compositions comprising isocyanate-functional curing agents, film-forming compositions with functional groups reactive with the isocyanates, and polysiloxanes. The film-forming compositions can be applied directly to the surface of the substrate or onto a primer coat and/or topcoat on the substrate.
US08765227B2 Mounting device for mounting a bodyshell sliding door of a motor vehicle
An improved mounting device for mounting a bodyshell sliding door to a body-in-white of a motor vehicle during a painting operation comprises a body connection which can be mounted to the body-in-white and a door connection which can be mounted to the bodyshell sliding door. The body connection and the door connection are connected with each other by a multiple joint.
US08765226B2 Method for patterning using phase-change material
A patterned layer over a wafer is produced by depositing a print-patterned mask structure. Energized particles of a target material are deposited over the wafer and the print-patterned mask such that particles of said target material incident on the mask structure enter the mask structure body and minimally accumulate, if at all, on the surface of the mask structure, and otherwise the particles of target material accumulate as a generally uniform layer over the wafer. The print-patterned mask structure, including particles of target material therein, is removed leaving the generally uniform layer of target material as a patterned layer over the wafer.
US08765222B2 Method of manufacturing a p-AlGaN layer
The method according to the present invention includes a first step of supplying the Group V source gas at a flow rate B1 (0
US08765220B2 Methods of making and deposition methods using hafnium- or zirconium-containing compounds
Disclosed are hafnium- or zirconium-containing compounds. The compounds may be used to deposit hafnium- or zirconium-containing layers using vapor deposition methods such as chemical vapor deposition or atomic layer deposition. The hafnium- or zirconium-containing compounds include a ligand at least one aliphatic group as substituents selected to have greater degrees of freedom than the substituents disclosed in the prior art.
US08765214B2 Cleaning method for coating systems
The present invention relates to a pretreatment method to be applied to secondary surfaces in coating systems prior to coating. To this end, a non-stick coating is applied to the secondary surfaces, which can be easily detached from the secondary surfaces, even after coating material has been deposited thereon. In this way, the cleaning process of the coating system after the coating process is considerably simplified.
US08765213B2 Method for making lithium-ion battery electrode material
The present disclosure relates to a method for making an electrode material of lithium-ion batteries. In the method, a carbon source compound is dissolved into a solvent to form a liquid phase solution. A number of titanium dioxide particles are provided and are dispersed into the liquid phase solution. The carbon source compound is pyrolyzed, thereby forming a number of carbon coating titanium dioxide particles. A lithium source solution is provided. The lithium source solution and the carbon coating titanium dioxide particles are mixed, according to a molar ratio in a range from about 4:5 to about 9:10, of lithium element to titanium element, thereby forming a sol. The sol is spray dried to form a number of precursor particles. The precursor particles are heated to form a lithium titanate composite electrode material.
US08765205B2 Sweetened consumables comprising rebaudioside A and stevioside as sweetness enhancers and method of enhancing sweetness of consumables
Disclosed are sweetened consumables and methods of forming said sweetened consumables that comprise certain sweeteners and at least one sweetness enhancer in a concentration near its sweetness detection threshold. The sweeteners include sucrose, fructose, glucose, high fructose corn syrup, corn syrup, xylose, arabinose, rhamnose, erythritol, xylitol, mannitol, sorbitol, inositol, acesulfame potassium, aspartame, neotame, sucralose, saccharine, or combinations thereof. The sweetness enhancer is selected from naringin dihydrochalcone, mogroside V, swingle extract, rubusoside, rubus extract, rebaudioside, and stevioside.
US08765203B1 Process for seasoning low-fat snacks
A method for preparing a low-fat snack food fries the snack food, removes some of the oil accumulated by the frying, re-applies oil onto the surface of the snack food and then applying a seasoning or flavoring that adheres to the snack food via the surface coating of oil.
US08765197B2 Extract of herbal and composition containing the same
The present invention relates to herbal extracts of Sinapis Semen, Corydalis Tuber, Pharbitidis Seed, and Strychni Ignatii Semen, and a composition containing the same for treating and preventing gastrointestinal motility disorder. The extracts of the present invention have a remarkable effect of promoting gastrointestinal motility through HT3 receptor antagonism and/or HT4 receptor antagonism.
US08765195B2 Methods and compositions for increasing sex steroids and growth hormones
Embodiments of the invention generally relate to methods and supplements for increasing sex steroids and human growth hormone in a human being.
US08765194B2 Natural—topical analgesic and anti-inflammatory composition
This invention replaces the practice of utilizing synthesized salicin compounds for use as anti-inflammatory components in topical pain relief compositions through the use of naturally occurring salicin in the form of Salix alba (white willow bark) botanicals. This invention is a compound of naturally occurring botanicals identified in the Natural Pharmacopeia as individually exhibiting anti-inflammatory and/or analgesic properties.
US08765191B2 Cocoa extracts for use in providing skin benefits
A cocoa extract obtainable by the extraction of non-defatted cocoa beans which have not been fermented or have been allowed to ferment for no more than three days, having a polyphenol content of more than 25% by weight, may be used to provide skin benefits by oral administration.
US08765188B2 Composition for treating and/or preventing osteoporosis
The invention relates to a composition comprising deer velvet antler blood (DVAB) in combination with velvet antler for use in the treatment and/or prevention of osteoporosis and a method for treating and/or preventing osteoporosis, comprising administering a therapeutically effective amount of a composition comprising DVAB and velvet antler to a subject at risk of developing or afflicted with osteoporosis. The composition of the invention, when administered to a subject with osteoporosis, increases anti-osteoporotic activity, decreases the biomarker of osteoporosis and recovers the biomechanical strength and structure of bone, suggesting that the said composition could significantly prevent and even treat osteoporosis.
US08765185B2 Granules for pharmaceutical preparations, methods and apparatus for their production
Disclosed are improved granular pharmaceutical preparations, together with improved methods and apparatus for preparation of granules for use in such preparations. Such methods are especially useful for making granules for solid oral dose pharmaceutical preparations, and are particularly suited to the production of granules comprising 5-aminosalicylic acid (5-ASA) for the treatment of inflammatory bowel disease. The granules exhibit a more sharply peaked length distribution, and hence aspect ratio distribution, and have a consequently much sharper dissolution profile after further processing.
US08765183B2 Polymer microgel beads
The present invention relates to polymer microgel beads having a polymeric matrix with nanomagnetic particles dispersed substantially uniformly therethrough, wherein a steric stabiliser is associated with the particles, the steric stabiliser being a polymeric material that (i) does not form part of the polymeric matrix of the beads, and (ii) comprises a steric stabilising polymeric segment and an anchoring polymeric segment, wherein the steric stabilising polymeric segment is different from the anchoring polymeric segment, and wherein the anchoring polymeric segment has an affinity toward the surface of the nanomagnetic particles and secures the stabiliser to the particles.
US08765182B2 Microspheres
The invention relates to the production of microspheres having radial pores using thermally induced phase separation, especially microspheres for use in tissue engineering.
US08765180B2 Composition comprising calcium carbonate as a white pigment
A white coloring composition comprising calcium carbonate as a white pigment. It may be used in the manufacture of food and pharmaceutical products.
US08765175B2 Sustained release formulation of nalbuphine
Sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof; methods for making the sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof; and methods for using the sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof to treat patients suffering from pain are provided.
US08765170B2 Personal care composition in the form of an article
Personal care compositions, especially those personal care compositions in the form of an article that is a porous, dissolvable solid structure.
US08765165B2 Particulate cartilage system
The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.
US08765157B2 Topical skin composition comprising shea butter, jojoba oil, petroleum jelly, glycerin, and zinc oxide
The present invention relates to compositions and methods for the treatment of topical skin conditions, comprising of Cocoa butter and or petroleum jelly, jojoba oil, dihydrogen oxide, Stearic acid, Anhydrous Magnesium Sulphate, Zinc Oxide, Glycerin and a suitable amount of a pharmaceutically acceptable carrier, shea butter. U.S. Patent Documents 7,429,386September, 2008First 6,596,287July, 2003Deckers, et al. EP1750660March, 1930McClung 5,134,163July, 1992Kligman 4,603,146July, 1986Kligman 4,165,385August, 1979Lefebvre 4,454,118June, 1984Johnson 5,503,825April, 1996Lane
US08765154B2 Transparent softening agents
The invention relates to transparent softening agents containing: (a) ester quaternaries, which are obtained by reacting alkanolamines with a mixture consisting of fatty acids and of dicarboxylic acids, whereby the resulting esters are optionally alkoxylated and subsequently quaternized in a known manner, and containing; (b) auxiliary agents selected from the group formed by: (b1) fatty acid amidoamines and/or quaternization products thereof; (b2) betaines; (b3) nonionic surfactants; (b4) polyols and/or derivatives thereof; (b5) alcohols and/or; (b6) hydrotropes.
US08765153B2 Levalbuterol salt
Levalbuterol L-tartrate affords crystals possessing properties desirable for use in a metered dose inhaler.
US08765148B2 1C31 nanoparticles
The invention discloses pharmaceutical compositions in liquid form comprising a peptide with the amino acid sequence KLKL5KLK and an oligodeoxynucleotide with the nucleic acid sequence (dIdC)13 and wherein the peptide and the oligodeoxynucleotide are present as sterile-filterable nanoparticles in the composition, thereby forming a suspension, characterized in that the mean particle size of the solid particles is less than 1 μm.
US08765146B2 Adenoviral vector-based malaria vaccines
The invention provides adenoviral vectors comprising an adenoviral genome comprising heterologous antigen-encoding nucleic acid sequences, such as Plasmodium nucleic acid sequences, operably linked to promoters. The invention further provides a method of inducing an immune response against malaria in a mammal comprising administering the adenoviral vectors to the mammal.
US08765145B2 LSA-5 liver stage and blood stage antigen of Plasmodium falciparum, immunogenic composition comprising said antigen, and vaccines against malaria
The present invention pertains to the protection against malaria. More particularly, the invention is based on the characterization of a novel liver and sporozoite-stage P. falciparum antigen, referred to as LSA-5. This antigen is highly antigenic and the prevalence of antibodies in subjects living in endemic areas is extremely high (ca. 90%). The invention concerns antigenic peptides, mixtures thereof, or polypeptides, mixotopes and conjugates comprising part of the sequence of LSA-5, as well as immunogenic compositions, vaccines and kits comprising these.
US08765143B2 Fusion proteins and use thereof for preparing hepatitis C vaccines
An immunogenic fusion protein includes at least, on the C-terminal side, a first peptide composed of the S protein deleted of the transmembrane domain thereof located at the N-terminal end thereof, of a hepatitis B virus (HBV) isolate, and on the N-terminal side, a second peptide composed of the transmembrane domain and of the ectodomain of at least one envelope protein of a hepatitis C virus (HCV) isolate. A hybrid nucleic acid molecule encoding the fusion protein, and a vector including the hybrid nucleic acid molecule, a subviral particle including the fusion protein, an immunogenic composition including at least the fusion protein, or at least the hybrid nucleic acid molecule, or at least the subviral particle, and a cell line for the production of the fusion protein, or of the hybrid nucleic acid molecule, or of the subviral particle are described.
US08765137B2 Gp41 antigens
The present invention deals with a modified polypeptide comprising three contiguous segments N, L and C represented by the formula N-L-C and comprising: a N-helix region of gp41 (N), a C-helix region of gp41 (C), and a connecting loop comprising a synthetic linker (L) between the N and C-helices, the linker replacing amino acids 593-617 of gp41, the numbering scheme being based upon the prototypic isolate HIV-1 HxB2 Clade B strain, said polypeptide comprising the calveolin-1 neutralizing and 98.6 D epitopes, but not 2F5 and 4E10 epitopes, not the fusion peptide, the polypeptide having a minimal immunogenic cross-reactivity with human interleukin 2 (IL2).
US08765134B2 Methods for treating chronic obstructive pulmonary disease
The present invention provides methods of treating a mammal having chronic obstructive pulmonary disease (COPD), independent of both smoking status and asthma status, with a therapeutically effective amount of an anti-IgE moiety. In accordance with the invention, COPD patients with an elevated serum IgE level may benefit from the treatment methods disclosed. In certain instances, the methods of the disclosure have been found to be useful for the treatment of COPD patients regardless of their skin test results and/or in vitro reactivity to a perennial aeroallergen. Anti-IgE moieties, in accordance with the invention, include but are not limited to any IgG antibody that selectively binds to a given mammal immunoglobulin E (e.g., human immunoglobulin E) such as humanized anti-IgE, humanized murine monoclonal antibody, and/or Omalizumab.
US08765128B2 Anti-cMET antibody
Antibody capable of binding specifically to the human c-Met receptor and/or capable of specifically inhibiting the tyrosine kinase activity of said receptor, with an improved antagonistic activity, said antibody comprising a modified hinge region. A composition comprising such an antibody antagonist to c-Met and its use as a medicament for treating cancer.
US08765124B2 Stabilized preparation containing protein
Protein formulations containing a poloxamer as a surfactant, and methods for maintaining the biological activity in protein formulations without adding an antioxidant and for inhibiting the formation of foreign insoluble matters by adding a poloxamer as a surfactant.
US08765123B1 Compositions and methods for the treatment and prevention of infections caused by Staphylococcus aureus bacteria
The present invention relates to antimicrobial deoxyribonuclease-based compositions that inhibit growth and proliferation of Staphylococcus aureus bacteria. The present invention also relates to methods of administering the compositions in the treatment and prevention of S. aureus infections. The present invention also relates to methods of administering the compositions in the eradication of S. aureus nasal carriage, in order to prevent the transmission of S. aureus bacteria.
US08765117B2 Generation of vascularized human heart tissue and uses thereof
The present invention relates to the generation of vascularized human heart tissue from human primordial Islet1-positive (ISL1+) progenitors, and more particularly the generation of vascularized human heart tissue from human primordial Islet1+ cardiovascular stem cells which are positive for markers ISL1+/NKX2.5−/KDR−. One aspect of the invention relates to isolation of human ISL1+ primordial cells from human pluripotent cells, such as human ES cells or other human pluripotent stem cell sources, wherein the human ISL1+ primordial cells can differentiate into three different lineages; cardiomyocyte lineages, endothelial lineages and smooth muscle lineages. Another aspect relates to use and implantation of the human primordial ISL1+ progenitors into an animal model to generate human vascularized heart tissue, and more particularly, the production of an in vivo humanized model of vascular disease. One embodiment relates to the use of an in vivo humanized model of vascular disease as an assay, for example to assess drug toxicity and/or identify agents which increase and decrease coronary blood flow to the human vascularized heart tissue. Another embodiment relates to the therapeutic use of human primordial ISL1+ progenitors, for example, in one embodiment the invention provides methods for the treatment cardiovascular disorders and/or congenital heart disease in a subject comprising transplanting into subjects vascularized human heart tissue generated from human ISL1+ progenitors.
US08765116B2 Apparatus and method for pre-conditioning/fixation and treatment of disease with heat activation/release with thermoactivated drugs and gene products
An apparatus and method for administering focused energy to a body using either a single energy applicator or multiple energy applicators to supply heat prior to, concurrently with and/or after delivery of a drug, gene and/or viral vector. A multi-modality treatment using a localized, focused and/or regional heating apparatus, which supplies heat to a defined area of a patient's body. The apparatus is used heat is used to pretreat a specific body site, to activate thermoactivated drugs, genes, or viral vectors, and/or to deliver drugs, genes, or viral vectors to the specific body site. The heating apparatus is provided with one or more variable and adjustable probes and one or more delivery ports heat the specific treatment site and to deliver the thermoactivated drugs and genes to the specific treatment site. Each probe may optionally be provided with one or more temperature sensors to allow for the temperature in the specific treatment site and the surrounding tissue to be properly regulated. The use of the apparatus and method allow for the heat conditioning of a specific treatment site and for the delivery or activation of a drug, gene, or viral vector limited to only the specific treatment site, allowing for a more accurate treatment of diseased tissue without damaging healthy tissue. In addition, this method is uniquely used with non invasive technologies to help determine on a real time basis the completion of the treatment.
US08765111B2 N-maleimidyl polymer derivatives
The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives.
US08765105B2 Human sebum mimetics derived from botanical sources and methods for making the same
Human sebum mimetics and methods for producing human sebum mimetics are provided. In one exemplary embodiment, a human sebum mimetic comprises a wax ester derived from interesterification of refined botanical oil comprising palmitoleic acid and refined jojoba oil, a phytosterol, and phytosqualene. A method for producing a human sebum mimetic comprises mixing refined macadamia oil and refined jojoba oil, interesterifying the refined macadamia oil and the refined jojoba oil, adding a phytosterol alter the interesterifying, and adding phytosqualene after the interesterifying.
US08765092B2 Non-stoichiometric perovskite oxide oxidation catalyst for oxidizing NO to NO2
A non-stoichiometric perovskite oxide having the general chemical formula LaXMnOY, in which the molar ratio of lanthanum to manganese (“X”) ranges from 0.85 to 0.95, can be used in particle form as an oxidation catalyst to oxidize NO to NO2 in an exhaust aftertreatment system for a hydrocarbon-fueled engine. The oxygen content (“Y”) fluctuates with variations in the molar ratio of lanthanum to manganese but generally falls somewhere in the range of 3.0 to 3.30. The crystal lattice adjustments spurred by the non-stoichiometric molar ratio of lanthanum to manganese are believed responsible for an enhanced NO oxidative activity relative to similar perovskite oxides with a higher molar ratio of lanthanum and manganese.
US08765079B2 Dispensing apparatus
A dispensing apparatus includes: a dish mounting portion having a mounting surface mounted with a dish having a bottom surface and a side surface surrounding the bottom surface; a syringe, arranged above the dish mounting portion, having a nozzle configured to discharge liquid toward an interior of the dish; and a first driving portion configured to change the syringe in direction with respect to a first axis as a center, wherein the first axis is orthogonal to a normal to the mounting surface of the dish mounting portion.
US08765078B2 Biochip stamping device and stamping method thereof
There is provided a biochip stamping device. The biochip stamping device includes a stamping jig in which a first biochip is aligned; an inverting mechanism vertically inverting a second biochip; and a movement mechanism transferring the vertically inverted second biochip on the stamping jig to combine the first biochip and the second biochip.
US08765077B2 Reagent dispensers and stackable bars for multiplex binding assays
Multiplex binding assay assemblies are disclosed. The assemblies generally include at least one assay bar that includes a top side, a bottom side, and at least one well accessible from the top side of the assay bar. Each well includes a side surface, a bottom surface, an open top end, and at least one secondary container, with each secondary container including a capillary tube that (i) begins at a location within an interior volume of the well and (ii) ends at a location beneath the bottom surface of the assay bar. The assemblies further include a dispenser bar that is adapted to be positioned adjacent to the top side of the assay bar, which includes one or more reservoirs that are configured to provide one or more reagents to the at least one secondary container located in each well of the assay bar.
US08765074B2 Multiple scent delivery device
A multiple scent delivery device includes a support housing having a plurality of holes therein and having an upper end and a lower end, a heating source removably connected to a lower end of said upwardly disposed support housing, a cone shaped inner flue operably disposed within the support housing having a plurality of holes therein and having an upper end and a lower end and an upper container removably disposed on the upper end of support housing in spaced-apart relationship above from the heating source for retaining an aromatic substance, whereby heat generated induces the retained aromatic substance within the upper container to disperse into the ambient air.
US08765066B2 Device and method for processing cement kiln combustion exhaust gas
A combustion exhaust gas processing device comprises: a dust collector collecting dust in a cement kiln combustion exhaust gas; a wet dust collector using sodium hypochlorite as a catalyst-poisoning-substance stripper for removing a catalyst-poisoning substance and mercury from a combustion exhaust gas which passed the dust collector; heaters downstream of the wet dust collector for heating the combustion exhaust gas from the wet dust collector; and a catalyst device from which NOx, a persistent organic pollutant, etc. in the heated combustion exhaust gas, are removed. An upstream side of the catalyst device is installed with an oxide catalyst such as titanium-vanadium and a downstream side is installed with a platinum catalyst as a noble-metal catalyst. The temperature of the combustion exhaust gas after the wet dust collector is increased up to 140° C. or more with the heaters to prevent decline in denitration efficiency of and the decomposition efficiency of a volatile organic compound. A mercury adsorbing tower is provided for adsorbing the mercury in liquid exhausted from the wet dust collector and wastewater from the liquid is used to generate sodium hypochlorite for use in the wet dust collector.
US08765063B1 Air freshener cartridge with mounting
An air freshener cartridge with mounting that includes a housing with a mounting clip configured to releasably engage with an extant air vent cover to removably secure the air freshener cartridge with mounting thereto, the air cartridge with mounting oriented in a position normal the direction of airflow issuing through said vent.
US08765062B2 Systems and devices for analysis of samples
Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.
US08765061B2 Systems and methods for inspecting and monitoring a pipeline
Disclosed are systems and methods for inspecting and monitoring an inner surface of a pipeline. One system includes a pig arranged within the pipeline and having a housing that defines a conduit therein for providing fluid communication through the pig, one or more optical computing devices arranged on the conduit for monitoring a bypass fluid flowing through the conduit. The one or more optical computing devices including at least one integrated computational element configured to optically interact with the bypass fluid and generate optically interacted light, and at least one detector arranged to receive the optically interacted light and generate an output signal corresponding to a characteristic of the bypass fluid. A signal processor is communicably coupled to the at least one detector of each optical computing device for receiving the corresponding output signals and determining the characteristic of the fluid.
US08765060B2 Chemical sensor
A device for detecting an analyte present in a fluid includes a fluorous sensing phase into which the analyte enters selectively in comparison with other components of the fluid.
US08765055B2 Bubble trap systems for infusion pump devices
Bubble traps for removing bubbles from a stream of liquid and flexible containers comprising such bubble traps are disclosed. The bubble trap includes a containment chamber fluidly coupled to an outlet conduit. At least one grate is disposed between the containment chamber and the outlet conduit. The at least one grate includes a plurality of grate inlets formed in a grate wall and fluidly coupled to the outlet conduit with a plurality of grate conduits such that the containment chamber is fluidly coupled to the outlet conduit. The grate traps bubbles entrained in the stream of liquid flowing from the containment chamber to the outlet conduit in the containment chamber when the bubbles are greater than or equal to a diameter of the grate inlets.
US08765054B2 Process for treatment of residual nucleic acids present on the surface of laboratory consumables
Process for treatment of residual nucleic acids present on the surface of laboratory consumables. The process combines two treatment phases: (1) treatment with ethylene oxide in gaseous phase; then (2) treating the surface with hydrogen peroxide in liquid phase or in gaseous phase. The effect of this treatment is the avoidance of the amplification of residual nucleic acids, in particular during PCR or TMA reactions.
US08765053B2 Sn based alloys with fine compound inclusions for Nb3Sn superconducting wires
A method for producing a Sn based alloy (15) comprising a metal matrix of a metal matrix material, wherein the metal matrix material comprises Sn, and inclusions of a compound material, further referred to as compound inclusions, wherein the compound material contains one element or a combination of elements of the group Ti, V, Zr, Hf, further referred to as dopant, and one or a plurality of other elements, in particular Sn, Cu and/or Nb. Particles of the metal matrix material, further referred to as matrix particles, are mixed with particles of the compound material, further referred to as compound particles, and the matrix particles and the compound particles are compacted during and/or after their mixing. A Sn based alloy containing finer compound inclusion of a dopant can be prepared, in order to produce Nb3Sn superconductor material with a superior current carrying capacity.
US08765052B2 Abrasion and corrosion resistant alloy and hardfacing/cladding applications
Weld deposit compositions with improved abrasion and corrosion resistance are provided by balancing percent weights of Chromium (Cr), Titanium (Ti), Niobium (Nb), and Boron (B) to allow the Chromium content of the weld matrix to be minimally reduced during carbide formation. The result is an enriched Chromium matrix that has excellent corrosion resistance in combination with highly abrasion resistant dispersed carbides.
US08765045B2 Surface-treatment method for rapid-manufactured three-dimensional objects
A method for forming a surface-treated, three-dimensional object, comprising: solvent smoothing an exterior surface of a rapid-manufactured, three-dimensional object, and media blasting at least a portion of the solvent-smoothed exterior surface.
US08765044B2 Method of making masonry blocks
A method of making a masonry block employing a mold assembly having a plurality liner plates each having a major surface that together form a mold cavity having an open top and an open bottom, wherein at least one liner plate is moveable between a retracted position and a desired extended position within the mold cavity. The method includes providing a negative of a desired texture on the major surface of the moveable liner plate, moving the moveable liner plate to a retracted position, closing the bottom of the mold cavity by positioning a pallet below the mold assembly, filling the mold cavity with dry cast concrete via the open top, vibrating the mold assembly and dry cast concrete therein, and moving the moveable liner plate to a desired extended position during the vibrating.
US08765043B2 Method of producing a foam material product
The invention relates to a method of producing a foam product (1), whereby a body (2) of expanded closed-cell foam, in particular expanded polystyrene particle foam, is subjected to a non-melting heat treatment at a temperature above the glass transition temperature of the plastic used to form the foam, in particular polystyrene.
US08765042B2 Fuselage section of an aircraft and method for the production of the fuselage section
In accordance with the method, an inside layer of a fuselage section skin made from first fibers is placed on a manufacturing surface, the first fibers being placed in one or more first fiber directions. On the inside layer, a stiffening structure is formed from stiffening fibers, the stiffening fibers being placed in one or more stiffening fiber directions. An outside layer of the fuselage section skin, comprising fourth fibers, is placed on the stiffening structure formed from stiffening fibers, the fourth fibers being placed in one or more fourth fiber directions. The stiffening structure is designed and developed in such a way that the fuselage section does not require an additional stiffening structure, is connected with the fuselage section skin, and comprises the inside layer, the stiffening structure, and the outside layer; in particular, an additional stiffening structure in the form of stringers and frames is not required.
US08765040B2 Medical device fabrication process including strain induced crystallization with enhanced crystallization
Methods of fabricating a polymeric implantable device, such as a stent, with improved fracture toughness through annealing a polymer construct below the glass transition temperature of the polymer of the construct prior to a deformation step are disclosed herein. The deformation of the construct induces crystallization in the polymer construct through strain-induced crystallization. The annealing of the polymer construct accelerates the crystallization induced during the deformation and results in an increase in crystallite density with smaller crystallites as compared to deformation of a tube that has not been annealed. A stent scaffolding is then made from the deformed tube.
US08765035B2 Process for manufacturing a self-extinguishable cable
A process for manufacturing a self-extinguishing cable including at least one transmissive element and at least one flame-retardant coating in a position radially external to the at least one transmissive element, wherein the at least one coating includes an expanded flame-retardant polymeric material having (a) at least one expandable polymer; (b) at least one expanding agent; (c) at least one flame-retardant inorganic filler, in an amount of 100 parts by weight of 250 parts by weight with respect to 100 parts by weight of the at least one expandable polymer. The process includes the following steps: (i) feeding the flame-retardant polymeric material to an extruding apparatus, therein melting and mixing it; (ii) passing the flame-retardant polymeric material obtained in step (i) through at least one static mixer; and (iii) depositing by extrusion the flame-retardant polymeric material obtained in step (ii) onto the at least one transmissive element conveyed to the extruding apparatus.
US08765032B2 Process for producing a graphite cage for an anti-friction bearing, which cage holds a plurality of anti-friction elements
A process for producing a graphite cage for an anti-friction bearing, which cage holds a plurality of anti-friction elements. A cage injection molding is injected in an injection molding process from a mass which contains carbon mesophase powder, and this cage injection molding is subsequently heat-treated in order to transform the carbon from the mesophase into pure graphite.
US08765031B2 Method of forming a dental appliance
The present disclosure includes dental appliances and methods of making and using such appliances. One method for forming a dental appliance includes forming a liquid thermoset polymer material into a semi-solid first shape, thermoforming the semi-solid first shape of thermoset polymer material onto a dentition mold, and curing the thermoset polymer on the dentition mold with a curative trigger to complete a molecular cross-linking reaction.
US08765030B2 Preparation of an enteric release system
Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents, the process including forming an emulsion of the enteric material and hydrophobic liquid in water, the emulsion titrated with an acid to form a particulate precipitate of the microencapsulated hydrophobic liquid in an enteric matrix.
US08765027B2 Polymer composition
A polymer composition comprises at least one substantially non-conductive polymer binder and at least first and second electrically conductive fillers. The first electrically conductive filler is comprised of particles having avoid-bearing structure; and the second electrically conductive filler is comprised of particles which are acicular in shape.
US08765022B2 Water dispersible polypyrroles made with polymeric acid colloids for electronics applications
Compositions are provided comprising aqueous dispersions of at least one polypyrrole and at least one colloid-forming polymeric acid. The colloid-forming polymeric acid may be fluorinated. The new compositions are useful in electronic devices including organic electronic devices such as organic light emitting diode displays, memory storage, electromagnetic shielding, electrochromic displays, and thin film transistors, field effect resistance devices.
US08765016B2 Green luminescent material of terbium doped gadolinium borate and preparing method thereof
A green luminescent material of terbium doped gadolinium borate is provided. The luminescent material has a formula of M3Gd1-xTbx(BO3)3, wherein, M is alkaline earth metal element and x is 0.005-0.5. The method for preparing the luminescent material comprises the following steps: selecting the source compounds of alkaline earth metal ion, boric acid radical ion (BO33−), Gd3+ and Tb3+ by the stoichiometric ratio, wherein, the stoichiometric ratio is the molar ratio of the corresponding element in the formula of M3Gd1-xTbx(BO3)3, and the source compound of BO33− is over 10%-30% by the molar ratio; mixing; pre-treatment by sintering; cooling; grinding; calcination; and cooling to obtain the luminescent material.
US08765011B2 Fluorovinyl derivative, liquid crystal composition and liquid crystal display device
To provide a liquid crystal compound having general physical properties required for the compound, namely, a high stability to heat, light and so forth, a small viscosity, a refractive index anisotropy value having a suitable magnitude, a dielectric constant anisotropy value having a suitable magnitude and steep electro-optical characteristics, a wide temperature range of a nematic phase, and an excellent compatibility with other liquid crystal compounds, in particular, a liquid crystal compound having a wide temperature range of the nematic phase; the compound is represented by formula (1): wherein R is alkenyl having 2 to 20 carbons; ring A1 and ring A2 are independently 1,4-cyclohexylene, or 1,4-phenylene in which at least one of hydrogen may be replaced by fluorine; Z1 and Z2 are independently a single bond, —CH2CH2—, —CH═CH—, —CH2O— or —OCH2—; and n is 0 or 1.
US08765008B2 Hydroxyalkylated polyalkylenepolyamine composition, method for producing same and method for producing polyurethane resin using such hydroxyalkylated polyalkylenepolyamine composition
Provided is a hydroxyalkylated polyalkylene polyamine composition, and a method for preparing the composition at low cost. Further disclosed is a method for producing a polyurethane resin by using the hydroxyalkylated polyalkylene polyamine composition containing at least two hydroxyalkylated polyalkylene polyamines as defined herein.
US08765005B2 Refrigerator oil composition
Provided is a refrigerating machine oil composition including a base oil which contains at least one substance selected from the group consisting of monoether compounds, alkyleneglycol diethers, and polyoxyalkyleneglycol diethers having an average repetition number of an oxyalkylene group of 2 or less as a main component, and has a kinematic viscosity at 40° C. of 1 to 8 mm2/s. The refrigerating machine oil composition is preferably applied to refrigerators whose sliding parts are composed of an engineering plastic or provided with an organic coating film or an inorganic coating film. The refrigerating machine oil can improve energy-saving performance due to its low viscosity, has high sealing property and excellent load capacity, and is suitably used in various refrigeration applications, especially in closed-type refrigerators.
US08765004B2 Composition comprising 2,3,3,3-tetrafluoropropene and 1,1,1,2-tetrafluoroethane, chillers containing same and methods of producing cooling therein
Disclosed herein is a chiller apparatus containing a composition comprising from about 6 to about 70 weight percent 2,3,3,3-tetrafluoropropene and from about 30 to about 94 weight percent 1,1,1,2-tetrafluoroethane. Also disclosed herein is a method for producing cooling in a chiller comprising (a) evaporating a liquid refrigerant comprising from about 6 to 70 weight percent 2,3,3,3-tetrafluoropropene and from about 30 to 94 weight percent 1,1,1,2-tetrafluoroethane in an evaporator having a heat transfer medium passing therethrough thereby producing a vapor refrigerant; and (b) compressing the vapor refrigerant in a compressor. Also disclosed herein is a method for replacing a refrigerant in a chiller designed for using HFC-134a or CFC-12 as refrigerant, comprising charging said chiller with a composition comprising a refrigerant consisting essentially of from about 6 to 70 weight percent 2,3,3,3-tetrafluoropropene and from about 30 to 94 weight percent 1,1,1,2-tetrafluoroethane.
US08765003B2 Nanocomposite thermoelectric conversion material and process for producing same
The invention provides a nanocomposite thermoelectric conversion material (1) in which the matrix has a polycrystalline structure, and crystal grains (10) and a crystal grain boundary phase (12) of a different composition are present therein, and in which the same type of phonon-scattering particles (14) are dispersed within the crystal grains (10) and the crystal grain boundary phase (12).
US08764999B2 Sidewall image transfer pitch doubling and inline critical dimension slimming
A method for patterning a substrate is described. The patterning method may include performing a lithographic process to produce a pattern and a critical dimension (CD) slimming process to reduce a CD in the pattern to a reduced CD. Thereafter, the pattern is doubled to produce a double pattern using a sidewall image transfer technique.
US08764996B2 Methods of patterning a material on polymeric substrates
A method of patterning a first material on a polymeric substrate is described. The method includes providing a polymeric film substrate having a major surface with a relief pattern including a recessed region and an adjacent raised region, depositing a first material onto the major surface of the polymeric film substrate to form a coated polymeric film substrate, forming a layer of a functionalizing material selectively on the raised region of the coated polymeric film substrate to form a functionalized raised region and an unfunctionalized recessed region, and etching the first material from the polymeric substrate selectively from the unfunctionalized recessed region.
US08764993B2 SiOC membranes and methods of making the same
A method of making a porous SiOC membrane is provided. The method comprises disposing a SiOC layer on a porous substrate, and etching the SiOC layer to form through pores in the SiOC layer. A porous SiOC membrane having a network of pores extending through a thickness of the membrane is provided.
US08764992B2 Method of fractionating oxidic nanoparticles by crossflow membrane filtration
A method of fractionating a dispersion of oxidic nanoparticles wherein at least one step of the method is a membrane crossflow filtration step, the flow of the dispersion over the membrane being brought about by means of driven rotating parts; and dispersions of oxidic nanoparticles that are obtainable by the method.
US08764991B2 Dewatering biomass material comprising polysaccharide, method for extracting polysaccharide from biomass material, and dewatered biomass material
A process for dewatering biomass material comprising polysaccharide and water. The process comprises wetting the biomass material with a wetting composition comprising an alcohol to form a biomass slurry comprising wetted biomass material and a liquid component, mechanically separating a portion of the liquid component from the biomass slurry, and mechanically separating at least a portion of the water from the wetted biomass material. A process for extracting polysaccharide from the biomass material and a dewatered biomass material are also disclosed.
US08764990B1 Liquid/refuse separation system
A system to permit separation of liquid and solid refuse in a single trash bin receptacle to facilitate the reliable sanitary disposal of such mixed items is provided. The overall system includes a trash receptacle device for deposit and separation of liquid and solid refuse including a reservoir for separated liquids as well as an easy-to-use and -operate liquid removal component, and a removable thermoplastic, flexible collection bag with appropriately located openings that allow for fluid transfer via gravitational forces and yet still retains suitable dimensional stability to collect and retain substantially all deposited solid refuse during further transport. Such a new system is particularly useful in retail settings (i.e., restaurants, bars, hospitals, fast food places, and the like) wherein quick clean-up of patrons' refuse is necessary without the requirement for inefficient separation of liquid and solid items by hand. Such a viable, reliable and effective liquid/solid separation system as well as the method of use of such a device is encompassed within the instant invention, as is the novel collection bag on its own.
US08764985B2 Basal screen for enhancing algal biomass growth
A three-dimensional grid for use as an algal turf growing surface contains a horizontal planar basal net containing a series of horizontal planar members and upwardly directed members.
US08764983B2 Filter element and filter module
A filter element of a filter system for filtering fluids has a filter medium with end faces. Terminal bodies, one each, are connected to one of the end faces of the filter medium, respectively. A support body extends between the terminal bodies. A first terminal body is connected by a toothed connection to the support body for transmitting a torque from the first terminal body onto the support body and from the support body onto the first terminal body.
US08764980B2 Filtration system and method
Embodiments of the invention provide a filtration system comprising a filter tank. In some embodiments, at least portions of an inlet pipe and an outlet manifold can be positioned within the filter tank. At least one manifold assembly can be coupled to the outlet manifold and also can be positioned within the filter tank. In some embodiments, the manifold assembly can include at least one first aperture, at least one second aperture, and at least one first cavity positioned within the manifold assembly. In some embodiments, the second aperture can fluidly connect the first cavity and the outlet manifold. Also, at least one filter can be coupled to the manifold assembly so that the first aperture fluidly connects the filter to the first cavity.
US08764976B2 Biological wastewater system having a screen structure for confining biofilm carriers to a reactor forming a part of the system
A biological wastewater treatment system includes a tank or reactor for holding and treating wastewater. Disposed in the tank or reservoir is an array of biofilm carriers for supporting biomass that remove pollutants and contaminates from the wastewater. A screen structure is mounted to the tank for screening treated wastewater flowing from the tank and preventing the biofilm carriers from being discharged from the tank. The screen structure includes a vertical screen made up of a plurality of screen modules disposed in side-by-side relationship and disposed upstream of an outlet formed in the tank. Further this screen structure may include a plurality of auxiliary screens that project form the vertical screen inwardly towards the interior area of the tank thereby providing increased screening area through which wastewater is discharged during a wastewater treatment process. The auxiliary screens include a screen area that extends around an open area and wherein wastewater passes through the screen area of the auxiliary screens into the interior area and from the interior area the wastewater passes through the plane of the vertical screen.
US08764973B2 Methods for upgrading of contaminated hydrocarbon streams
A method of upgrading a heteroatom-containing hydrocarbon feed by removing heteroatom contaminants is disclosed. The method includes contacting the heteroatom-containing hydrocarbon feed with an oxidant to oxidize the heteroatoms, contacting the oxidized-heteroatom-containing hydrocarbon feed with caustic and a selectivity promoter, and removing the heteroatom contaminants from the heteroatom-containing hydrocarbon feed. The oxidant may be used in the presence of a catalyst.
US08764965B2 Electrochemical conversion of alkali sulfate into useful chemical products
Electrochemical processes to convert alkali sulfates into useful chemical products, such as syngas, alkali hydroxide, and sulfur are disclosed. An alkali sulfate is reacted with carbon to form carbon monoxide and alkali sulfide. In one embodiment, the alkali sulfide is dissolved in water and subjected to electrochemical reaction to form alkali hydroxide, hydrogen, and sulfur. In another embodiment, the alkali sulfide is reacted with iodine to form alkali iodide sulfur in a non-aqueous solvent, such as methyl alcohol. The alkali iodide is electrochemically reacted to form alkali hydroxide, hydrogen, and iodine. The iodine may be recycled to react with additional alkali sulfide. The hydrogen and carbon monoxide from both embodiments may be combined to form syngas. The alkali hydroxide from both embodiments may be recovered as a useful industrial chemical.
US08764963B2 Electrode
A process for producing alkali metal chlorate that includes introducing an electrolyte solution containing alkali metal halide and alkali metal chlorate to an electrolytic cell, electrolyzing the electrolyte solution to produce an electrolyzed chlorate solution, transferring the electrolyzed chlorate solution to a chlorate reactor to produce a more concentrated alkali metal chlorate, wherein the electrolytic cell is a non-divided electrolytic cell that includes: at least one anode or at least one cathode that includes an electrode substrate comprising M(n+1)AXn, where M is a metal of group IIIB, IVB, VB, VIB or VIII of the periodic table of elements or a combination thereof, A is an element of group IIIA, IVA, VA or VIA of the periodic table of elements or a combination thereof, X is carbon, nitrogen or a combination thereof, where n is 1, 2, or 3; and an outlet for transferring electrolyzed solution to the chlorate reactor.
US08764962B2 Extraction of liquid elements by electrolysis of oxides
An electrolytic extraction method wins a target element from an oxide feedstock compound thereof. The feedstock compound is dissolved in an oxide melt in contact with a cathode and an anode in an electrolytic cell. During electrolysis the target element is deposited at a liquid cathode and coalesces therewith. Oxygen is evolved on an anode bearing a solid oxide layer, in contact with the oxide melt, over a metallic anode substrate.
US08764960B2 Manufacturing methods for metal clad laminates
The present invention relates to the manufacturing method of metal clad laminates by forming a conductive layer on a single side or both sides of a material film that is made of an insulating material using the silver complexes having a unique structure and electroplating metals outside of said conductive layer. The present invention can provide the manufacturing method of metal clad laminates, which has a fast operation speed for mass production, simple process steps to minimize defective ratio and cheap production cost.
US08764956B2 Method of regulating pH of fluid using the microfluidic device
A microfluidic device for electrochemically regulating the pH of a fluid includes: an ion-exchange material; an anode chamber having a surface defined by a surface of the ion-exchange material and an anode electrode disposed along an edge of the surface of the anode chamber; and a cathode chamber having a surface defined by an opposite surface of the ion-exchange material and a cathode electrode disposed along an edge of the surface of the cathode chamber.
US08764955B2 Gas sensor
A gas sensor (200) includes a gas sensor element (10) extending in the direction of an axis O, and a housing (50) made of metal, radially surrounding the gas sensor element, and adapted for inserting at least partially into a sensor-mounting hole (350) of a mounting body (300). The gas sensor (200) further includes a resin member (60, 61) which radially surrounds the housing at least partially and having a contact portion (C) in contact with the housing that is at least partially disposed axially frontward with respect to the outer surface of the mounting body (300) around the sensor-mounting hole, and a heat sink member (80) that is in contact with the housing at an axial position the same as or located frontward of the axial position of the front end of the contact portion.
US08764954B2 Smart sensor ports and methods of using same
The present disclosure provides an orientation-nonspecific sensor port for use in analyte meters designed to detect and quantify analyte levels in a fluid sample along with methods of using the same. The present disclosure also provides compositions and methods for facilitating the correct insertion of a sensor into a corresponding analyte meter.
US08764953B2 System and method for chemical potential energy production
The present invention relates to a system comprising a heat source to provide heat at the desired temperature and energy field (e.g. a solar concentrator); an electron source configured and operable to emit electrons; an electric field generator generating an electric field adapted to supply energy sufficient to dissociate gas molecules; and a reaction gas chamber configured and operable to cause interaction between the electrons with the molecules, such that the electrons dissociate the molecules to product compound and ions via dissociative electrons attachment (DEA) within the chamber.
US08764940B2 Embossed fibrous structures
A rolled web of cellulosic paper. The rolled web having a machine direction and a cross direction, the rolled web comprising at least two visually distinct repeating emboss patterns of machine direction oriented embossments. Each the repeating emboss pattern comprise a first region comprising a first emboss design and a first width; a second region comprising a second emboss design and a second width; and a third region disposed between and contiguous with the first and second regions, the third region comprising a third emboss design and a third width. Each of the repeating emboss patterns have a repeat pattern width, the repeat pattern width being measured in the cross direction of the rolled web, the repeat pattern width being the sum of the first, second, and third widths of the repeating emboss pattern. Each of the repeating emboss patterns are parallel and separated from each other of the repeating emboss patterns in the cross direction, the separation being by a fourth region having a fourth width in the cross direction, the fourth width being greater than the pattern width.
US08764935B2 Tape feeder and a tape installing method in the tape feeder
In a structure that exfoliation is performed in the pitch sending of a carrier tape (15) by making a cover tape exfoliating mechanism (50) intervene between joining surfaces of a base tape (15a) and a cover tape (15e), in an exfoliation start position where an exfoliating knife tip (51f) of an acuminate shape, which is provided at a front end, starts to exfoliate the joining surface, a lower guide member (40), which guides the carrier tape (15) from below, is pushed up from the bottom side by a lever member (44), and when the carrier tape (15) is installed, the carrier tape (15) is pushed up together with the lower guide member (40) to make the exfoliating knife tip (51f) in the exfoliation start position to be aligned to the joining surfaces and enter between the joining surfaces.
US08764934B2 Device and method for removing a peelable seal
A container or array of containers that is are sealed with a peelable seal is transported via a conveyor along a processing path toward a desealing station at which an adhesive surface having a width substantially the same as or greater than the width of the seal is pressed against the upper surface of the peelable seal. A collection rod applies a downward pressure on the adhesive surface, pressing it against the seal and keeping the container or container array in position on the conveyor as the plate moves with the conveyor. As the leading edge of the seal passes the collection rod, the adhesive surface is rolled upward, away from the plane of the seal, pulling up on the leading edge of the seal to separate it from the container or container array while the container or container array is held down by the roller. The removed seal is then discarded.
US08764928B2 Methods for manufacturing a paint roller and component parts thereof with strips of compounded material
Described are methods of making a paint roller using preformed strips or core material made from a compound of polypropylene and calcium carbonate having between 5% and 66% calcium carbonate by weight. One or various compounds may be used to form portions of one or multiple components that make up the paint roller, including, for example, the thermoplastic strips, adhesives and/or the backing of a composite cover material. The materials can be assembled in a continuous manufacturing process.
US08764925B2 Apparatus and methods for manufacturing fiber bundles
An apparatus for the reeling up of fiber bundles, in particular of hollow fiber membrane bundles, and in particular for the manufacture of dialysis filters, includes a reel carrier rotatable around a main axis. The apparatus includes at least two reels which are rotatably supported on the reel carrier, with the axes of rotation of the reels being perpendicular to the main axis of the reel carrier. The apparatus can be used for the wrapping of a fiber bundle with a film, having a receiver of first and second side elements and a flexible channel fastened between them for the reception of the film and the fiber bundle. A drive is provided to move at least the first side element transversely to the channel, and at least one folding device movable transversely to the channel for the folding of the film around the fiber bundle.
US08764923B2 Laminated glazing
A laminated vehicle glazing comprising a first ply of a glazing material and a second ply of a glazing material having a substantially co-extensive ply of an interlayer material laminated there between, at least a portion of the ply of interlayer material having a wedged cross-section, wherein the ply of interlayer material is pre-shaped by stretching such that either: (a) when the wedge angle is calculated at a plurality of points across the glazing, by taking measurements of a deflection of a laser beam as it passes through the glazing, the standard deviation in the magnitude of the wedge angle of the wedged portion is less than 0.05 mrad; or (b) when a grid pattern is projected onto the glazing, the standard deviation in the displacement between observed primary and secondary images of portions of the grid is less than 0.85 mm.
US08764918B2 High strength steel pipe for line pipe superior in low temperature toughness and high strength steel plate for line pipe and methods of production of the same
The present invention provides high strength steel pipe for line pipe superior in low temperature toughness suppressed in drop of toughness of the HAZ and a method of production of the same, more particularly high strength steel plate for line pipe used as a material for high strength steel pipe for line pipe and a method of production of the same, in particular high strength steel pipe for line pipe superior in low temperature toughness characterized in that the chemical compositions of the base metal is, by mass %, C: 0.020 to 0.080%, Si: 0.01 to 0.50%, Mo: 0.01 to 0.15%, Al: 0.0005 to 0.030%, and Nb: 0.0001 to 0.030% contained in a range of C+0.25Si+0.1Mo+Al+Nb: 0.100% or less and the mixture of austenite and martensite present along prior austenite grain boundaries of the reheated part of the heat affected zone has a width of 10 μm or less and a length of 50 μm or less.
US08764915B2 Carburizing treatment apparatus and method
In order to provide a further uniform carburizing treatment to an article to be treated, a carburizing treatment apparatus which performs carburizing treatment by heating the article to be treated in a treatment chamber, the inside of which is under reduced pressure and in a carburizing gas atmosphere, includes a temperature measurement means for measuring temperatures in a plurality of regions inside the treatment chamber and a temperature adjustment means for individually adjusting temperatures in the plurality of regions on the basis of measurement results of the temperature measurement means so that the article to be treated is given a uniform carburizing treatment.
US08764913B2 Surface-coated metal nanoparticles, method for producing the same, and metal nanoparticle paste comprising the same
Surface-coated metal nanoparticles comprising: metal nanoparticles having an average particle diameter of 1 to 100 nm, and an organic coating film provided on a surface of each of the metal nanoparticles, wherein the organic coating film comprises a fatty acid having 8 or more carbon atoms and an aliphatic amine having 8 or more carbon atoms, and a molar ratio of the aliphatic amine to the fatty acid is aliphatic amine/fatty acid from 0.001/1 to 0.2/1.
US08764910B2 Method and a washing system for washing turbines
A turbine washing system having a water making apparatus at a turbine site having a turbine. The water making apparatus extracts water from air. A water delivery system delivers the extracted water from the water making apparatus to the turbine to clean the blades of the turbine while the turbine is on-line. A water feeder is provided for feeding the extracted water from the water making apparatus to the water delivery system.A method for cleaning turbines on-line comprises extracting water from air directly at a turbine site having a turbine and treating the air and the extracted water to obtain extremely clean water having a conductivity of less than 3. This extremely clean water is then fed to the turbine to clean the turbine blades while the turbine is on-line. Preferably the extremely clean water is fed through a deionizer before being fed to the turbine.
US08764907B2 Servicing a plasma processing system with a robot
A method for servicing a plasma processing system. The plasma processing system may include a plasma chamber. The plasma chamber may include a top piece and a bottom piece, wherein the top piece may be disposed above the bottom piece. The method may include using a robot device to control a lift mechanism to lift the top piece from the bottom piece. The method may also include extending a first member of the robot device into the top piece to perform a first set of tasks according to a first set of service procedures. The method may also include extending a second member of the robot device into the bottom piece to perform a second set of tasks according to a second set of service procedures.
US08764904B2 Fiber comprising starch and a high polymer
The present invention relates to a fiber having starch and a high polymer, and a web employing such a fiber.
US08764901B2 Removing a sheet from the surface of a melt using elasticity and buoyancy
Embodiments related to sheet production are disclosed. A melt of a material is cooled to form a sheet of the material on the melt. The sheet is formed in a first region at a first sheet height. The sheet is translated to a second region such that it has a second sheet height higher than the first sheet height. The sheet is then separated from the melt. A seed wafer may be used to form the sheet.
US08764892B2 Reabsorber for ammonia stripper offgas
A method for removal of CO2 from a flue gas stream, comprising the steps of: a) contacting a flue gas stream comprising CO2 with a first absorption liquid comprising NH3 such that the flue gas stream is depleted in CO2; b) contacting the flue gas stream depleted in CO2 of step a) with a second absorption liquid such that NH3 from the flue gas stream is absorbed in said second absorption liquid to form a flue gas stream depleted in CO2 and NH3; c) separating NH3 from the second absorption liquid such that a gas stream comprising NH3 is obtained; d) contacting said gas stream comprising NH3 separated in step c) with a third absorption liquid such that NH3 is absorbed in said third absorption liquid. A system for removal of CO2 from a flue gas stream, the system comprising: a CO2 absorption stage; an NH3 absorption stage; and a reabsorption stage.
US08764888B2 Drying substances, preparation and use thereof
There is provided herein a dryer polymer substance including a hetero-phase polymer composition including two or more polymers wherein at least one of the two or more polymers include sulfonic groups, wherein the substance is adapted to pervaporate a fluid. The fluid may include water, water vapor or both. There is also provided herein a process for the preparation of a dryer polymer substance adapted to pervaporate a fluid (such as water, water vapor or both) the process includes mixing two or more polymers, wherein at least one of the two or more polymers may include groups which are adapted to be sulfonated, to produce a hetero-phase polymer composition and processing the polymer blend into a desired form.
US08764886B2 Apparatus for separating liquid droplets out of a feed gas stream comprising them with a liquid loading of > 10 L of liquid/m3 of feed gas
An apparatus, for separating liquid droplets out of a feed gas stream, includes a delay vessel for preliminary separation of some of the liquid droplets out of the feed gas stream under gravity, with an inlet line for the feed gas stream and an outlet line for the gas stream which has been depleted of liquid droplets and which flows out of the delay vessel and a tangential supply thereof into a centrifugal droplet separator. The outlet line is arranged in the upper region of the delay vessel and spaced apart from the inlet line to such an extent that the delay time of the gas stream in the delay vessel is at a maximum, and with an outlet line for the liquid separated in the delay vessel at the base thereof.
US08764882B2 Fluid treatment method, fluid treatment apparatus, and fluid
A fluid treatment method reduces a concentration of a first component included in a fluid-to-be-treated. A fluid treatment apparatus reduces a concentration of a first component included in a fluid-to-be-treated. A concentration of a second component differing from the first component is reduced in the fluid-to-be-treated in order to obtain a first fluid. The first fluid passes through at least part of an adsorption unit in order to obtain a second fluid. The adsorption unit is capable of adsorbing both the first component and the second component and has at least an ability to adsorb the first component that is temperature dependent. A third fluid pass through a portion of the adsorption unit through which the first fluid has passed. The third fluid has a concentration of the second component that is lower than in the fluid-to-be-treated and a temperature that is higher than the fluid-to-be-treated.
US08764881B2 Gas separation membrane
A membrane suitable for separating a gas from a gas mixture comprising a non cross-linked PVAm having a molecular weight of at least Mw 100,000 carried on a support wherein after casting onto the support, said PVAm has been heated to a temperature in the range 50 to 150° C., e.g. 80 to 120° C.
US08764878B2 Copper nanowire preparation methods and compositions
Claimed methods do not rely on highly reactive reagents, highly corrosive solutions, high temperatures, or long reaction times. Nanowires produced from such methods are free of large attached nanoparticles that have accompanied previously disclosed copper nanowires. Such nanowires are useful for electronics applications.
US08764876B2 PCBN material, tool elements comprising same and method for using same
PCBN material consisting essentially of cubic boron nitride (cBN) grains and binder material, the content of the cBN grains being at least 80 weight percent of the PCBN material; the binder material comprising greater than 50 weight percent Al and a combined content of at least 5 weight percent of an iron group element and a refractory element, the iron group element selected from the group consisting of Co, Fe, Ni and Mn, and the refractory element selected from the group consisting of W, Cr, V, Mo, Ta, Ti, Hf and Zr.
US08764875B2 Method and apparatus for coproduction of pig iron and high quality syngas
Combined microwave heating and plasma/electric arc heating is utilized in several processes and apparatus which involve co-production of pig iron and high quality syngas, biomass to liquid fuel production, coal to liquid fuel production, co-gasification of biomass and coal, municipal solid waste treatment, waste-to-energy (agriculture waste, ASR and PEF), EAF dust and BOF sludge treatment to recover zinc and iron, hazardous bottom ash vitrification, and bromine, chlorine and sulfur removal/recycling.
US08764874B2 Arrangement, method, integrated circuit and device for routing requests
A request routing circuit includes m inputs for receiving m input request signals and n outputs for outputting a set of n output request signals. A routing subsystem within the request routing circuit is provided between the m inputs and the n outputs and comprises k inputs and n outputs, where m is greater than k, and where the routing subsystem is configured to operate over a plurality (m/k, rounded up to the next integer) of cycles to provide the set of n output request signals based on the m inputs to the n outputs.
US08764867B2 Aircraft oil flow management system for inverted flight
An oil flow management system reduces the amount of oil directed from an aircraft engine to the environment outside of the aircraft, even when the aircraft is in inverted flight. This decreases the amount of oil that becomes attached to exterior surfaces of the aircraft fuselage. A gaseous mixture including air and oil is directed from the aircraft engine to a separator, which separate the mixture into a gaseous component and an oil component. The oil component is directed from the separator to a reservoir via a unidirectional valve. When in a first orientation, the unidirectional valve allows oil to flow from the separator to the reservoir. However, when in a second orientation, the unidirectional valve blocks oil from flowing from the reservoir to the separator.
US08764864B1 Polycrystalline diamond compact including a polycrystalline diamond table having copper-containing material therein and applications therefor
Embodiments of the invention relate to polycrystalline diamond compacts (“PDCs”) comprising a preformed polycrystalline diamond (“PCD”) table including a thermally-stable region having a copper-containing material disposed interstitially between bonded diamond grains thereof, and methods of fabricating such PDCs. In an embodiment, a PDC includes a substrate, and a preformed PCD table having an interfacial surface bonded to the substrate and a generally opposing upper surface. The PCD table includes a plurality of diamond grains exhibiting diamond-to-diamond bonding therebetween and defining a plurality of interstitial regions. The preformed PCD table further includes a first region extending inwardly from the upper surface that includes a copper-containing material disposed therein and a second region extending inwardly from the interfacial surface that includes a nickel-containing material disposed therein.
US08764863B2 Composite shaped abrasive particles and method of forming same
A method of forming a shaped abrasive particle includes forming a first mixture and a second mixture in a single forming process into an integral precursor shaped abrasive particle, wherein the first mixture has a different composition than a composition of the second mixture.
US08764862B2 Element containing thermally stable polycrystalline diamond material and methods and assemblies for formation thereof
The disclosure provides a super abrasive element containing a substantially catalyst-free thermally stable polycrystalline diamond (TSP) body having pores and a contact surface, a base adjacent the contact surface of the TSP body; and an infiltrant material infiltrated in the base and in the pores of the TSP body at the contact surface. The disclosure additionally provides earth-boring drill bits and other devices containing such super abrasive elements. The disclosure further provides methods and mold assemblies for forming such super abrasive elements via infiltration and hot press methods.
US08764861B2 Process and plant for refining oil-containing solids
A process for refining oil-containing includes introducing the oil-containing solids to a reactor so as to expel an oil-containing vapor from the solids at a temperature of 300 to 1000° C. The oil-containing vapor expelled from the reactor is supplied to a cracker so as to crack heavy oil components of the oil-containing vapor. The cracked heavy oil components obtained in the cracker are separated and withdrawn from the cracker. The solids left in the reactor and an unevaporated fraction of heavy hydrocarbons are introduced into a furnace. The unevaporated fraction of heavy hydrocarbons in the furnace are burned at a temperature of 600 to 1500° C. The solids from the furnace are recirculated into the reactor. A conveying gas is supplied into a rising pipe, wherein the stream of solids withdrawn from the furnace is fluidized by the conveying gas and transported to the reactor through the rising pipe.
US08764860B2 System and method for gasification
A system includes a gasification vessel configured to receive a fuel and an oxidizer. The system also includes a gasifier disposed in the gasification vessel. The gasifier is configured to partially oxidize the fuel and the oxidizer to generate a syngas. The system further includes a convective syngas cooler configured to cool the syngas via heat exchange with a coolant. The convective syngas cooler is disposed in an interior of the gasification vessel.
US08764858B2 Hydrogen gas generating apparatus with expandable reaction chamber
A hydrogen gas generating apparatus for providing hydrogen gas to a fuel cell stack is provided. The apparatus includes an expandable reaction chamber containing a solid reactant component and a collapsible receptacle containing a liquid reactant component with a housing. The reaction chamber includes an expandable reactant zone defined by a moveable partition that retains the reactants and reaction products within the reaction chamber. The apparatus also includes a liquid transport control system and a fluid path for transporting the liquid reactant component from the collapsible receptacle to the reactant zone in the reaction chamber, where the liquid and solid reactant components react to generate hydrogen gas. The receptacle collapses with a corresponding expansion of the reaction chamber as liquid reactant component is used, and the reactant zone expands within the reaction chamber in response to pressure from the increasing volume of reaction products on the moveable partition. Volume exchange among the expandable reaction chamber, the expandable reactant zone and the collapsible receptacle provides a high volume of hydrogen gas from a hydrogen generating apparatus of limited volume.
US08764856B2 Decoupled fluidized bed gasifying method and gasifying apparatus of solid fuel
The invention relates to a solid fuel decoupled fluidized bed gasifying method and a gasifying apparatus. By physically separately performing drying and pyrolyzing of fuel, gasification of char, and tar/hydrocarbon reforming, the interactions between the separated chemical reactions and physical processes during fluidized bed gasification can be utilized. Specifically, in a fluidized bed reactor having two reaction chambers, drying and pyrolyzing of fuel, gasification of char, and tar/hydrocarbon reforming are performed, respectively, the reforming of tar/hydrocarbon is promoted through the catalytic effect of the char, and the evaporated fuel moisture is provided to the char gasification and tar/hydrocarbon reforming as an effective reaction agent. Accordingly, the tar content in product gas can be reduced, the use amount of external steam can be reduced, the overall efficiency of gasification can be improved, and this technique can also be applied to the processing of high water-containing fuel. This gasifying method not only can be applied to individual fluidized bed gasification, but can contribute to the design of a combustor that combusts unreacted char, and to advanced decoupled fluidized bed gasification.
US08764853B2 Non-aqueous electrolytic solutions and electrochemical cells comprising the same
Non-aqueous electrolyte solutions capable of protecting negative electrode materials such as lithium metal and carbonaceous materials in energy storage electrochemical cells (e.g., lithium metal batteries, lithium ion batteries and supercapacitors) include an electrolyte salt, a non-aqueous electrolyte solvent mixture, an unsaturated organic compound 4-methylene-1,3-dioxolan-2-one or 4,5-dimethylene-1,3-dioxolan-2-one, and other optional additives. The 1,3-dioxolan-2-ones help to form a good solid electrolyte interface on the negative electrode surface.
US08764836B2 Circular glenoid method for shoulder arthroplasty
A method of shoulder arthroplasty in one embodiment includes accessing a scapula, identifying an inferior glenoid circle center of the scapula, preparing a glenoid fossa of the scapula to receive a prosthesis, selecting a glenoid component, and implanting the selected glenoid component based upon the identified inferior glenoid circle center in the prepared glenoid fossa.
US08764833B2 Artificial intervertebral disc with lower height
An intervertebral disc is provided having an upper plate, a lower plate, and a core. The upper and lower plates include outer vertebral body contacting surfaces which are provided with attachment enhancing features to ensure bone integration. The attachment enhancing features shown include one or more fins, serrations and teeth. An opposite surface of the plates from the vertebral body contacting surfaces is formed with a recess which serves as a bearing surface for the core. In order to form an intervertebral disc with a lower disc height, at least one of the recesses is provided opposite a corresponding dome shaped portion on the vertebral body contacting surfaces. This allows the plates to be formed with a thinner profile for a smaller overall disc height. In addition to providing a lower overall height to the artificial disc, the dome shaped portion of the plates also provides a more anatomically shaped outer vertebral body contacting surface.
US08764829B2 Buffer for a human joint and method of arthroscopically inserting
A buffer (10) for placement in a human knee between the femur and tibia comprises an outer sack (14) formed of a pliable material and having a one-way valve (22), a generally circularly shaped inner ring (16) received within the outer sack (14), and a friction reducing fluid (18) received within the outer sack (14) via the one-way valve (22). The inner ring (16) includes top and bottom surfaces (38,40) angled inwardly with respect to each other, such that the ring (16) is generally concave. The buffer (10) is configured for insertion between the femur and tibia so as to at least partially prevent the bones from contacting each other, which reduces the pain and discomfort associated with a loss of articular cartilage (12). The buffer (10) is arthroscopically inserted in the knee using an especially designed sleeve (20) configured for support of the buffer (10) during insertion.
US08764828B2 System and method for forming bone, ligament, and bone-ligament constructs
A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided.
US08764826B2 Middle ear prosthetic device
A middle ear prosthetic device including: a columellate prosthesis, one end of which is connectable to the stapes or to its remaining footplate; an annular element of bioinert metal insertable into the auditory tube after suitable milling; an elastic elongated element of bioinert material, disposed transversely to the annular element, a first end of the elongated element being rigid with the annular element while its second end is free and to it there being connected the other end of the columellate prosthesis; for supporting the neotympanum, a tensostructure of wires of non-reabsorbable bioinert material fixed taut to the interior of the annular element to support the neotympanum, the distance between the wires being such as to provide the surgeon with a sufficient view of the surgical field, the elongated elastic element interfering with the tensostructure.
US08764823B2 Semi-rigid framework for a plate haptic accommodating intraocular lens
A plate haptic for an accommodating intraocular lens. The plate haptic has a haptic body that is substantially rigid in a longitudinal direction and substantially flexible in a transverse direction. A chassis is integral to the haptic body. The chassis causes the haptic body to be substantially more rigid in a longitudinal direction than in a transverse direction.
US08764821B2 Degenerative vavlular disease specific annuloplasty ring sets
Annuloplasty rings optimally sized to take into account more of the common degenerative valve pathologies. Each ring has a structural ring body with a shape that complies with predicted shapes of degenerative valvular diseases. The predicted shapes are obtained through careful echocardiographic and intraoperative measurements, and often differ for different annulus orifice sizes. For instance, in mitral rings the larger rings have larger minor axis and oblique axis dimensions relative to their major axis dimensions, and are more circular as opposed to D-shaped. The rings may also be three-dimensional and the relative heights around the rings may change for different sized rings. A mitral ring may have a higher anterior saddle relative to a posterior saddle, with the relative heights varying across the ring sizes. The ring may have varying flexibility around the ring periphery which also changes for different ring sizes.
US08764815B2 Intraluminal stent
An intraluminal stent made of a zig-zag or sinusoidal member defining a successive series of struts connected by apex sections and formed into a series of axially displaced hoop members wherein at least one of the hoop members has at least 5 one strut connected to a strut of an adjacent hoop. The connected struts may be connected by spot welding, continuous welding, or suturing, for example, or by a bridging member connected to each strut, and may be spaced along the length of the stent in a pattern to form a connective spine. The number of zigs of the zig-zag member in each hoop member may be varied, as can the zig length. A plurality of 10 connective spines may also be included.
US08764811B2 Controlled tip release stent graft delivery system and method
An apparatus and method of deploying a stent graft having a proximal anchor stent ring includes restraining proximal apexes of the proximal anchor stent ring between a spindle body of a spindle and a control release sleeve of a tapered tip. The control release sleeve is advanced relative to the spindle to release a first proximal apex through an opening in the control release sleeve while the remaining proximal apexes remain restrained by the control release sleeve. The control release sleeve is further advanced relative to the spindle to release the remaining proximal apexes from the control release sleeve. In another example, a stent capture fitting has variable length stent capture fitting arms. As the stent capture fitting is retracted, the proximal apexes of the proximal anchor stent ring are sequentially exposed from and released by the variable length stent capture fitting arms. By using the control release sleeve or the stent capture fitting, controlled sequential release of the proximal apexes is achieved.
US08764809B2 Trochanter retention plate
The present disclosure relates to an implant for refixation of the greater trochanter on which an osteotomy has been performed or which is fractured. The implant comprises a plate that can be fixed on the proximal femur, and a device that can hold the greater trochanter with a form fit or force fit on the femur. This holding device preferably has bendable prongs located at a distance from each other, the first end portion of these prongs being attached to the upper edge of the base plate. The holding device also has flexible, elongate members, each of which is attached at one end to the free end portion of the respective prong. The other, free end portions of the longitudinal members are secured laterally on the base plate after these longitudinal members have crossed the medial aspect of the greater trochanter. This results in a tensioning band construction with at least two restraints based on a plate fixed securely on the proximal lateral femur.
US08764808B2 Bone fixation system
The invention provides embodiments of a bone fixation system having a bone plate and a specialized screws system. The bone plate includes one or more bi-directional combination holes that can accommodate two bone screws in the same hole, the screws being oriented in non-parallel direction. In accommodating two screws in the same hole, one of the screws has a by-pass head.
US08764806B2 Devices and methods for minimally invasive spinal stabilization and instrumentation
Described herein are devices and methods for fusion of adjacent vertebral bones using distractor platforms for exposure and resection of at least a portion of the facet joint, such as in performance of a TLiF procedure. In one embodiment, the distractor platform contains at least a first receptacle and/or extension adapted to couple to the implanted screw/bone marker and the method includes advancing a threaded segment of a bone fastener assembly into the identified first pedicle of the first vertebral bone, the first bone fastener assembly further comprises a second segment adapted to couple with a distraction platform adapted to concurrently attach onto at least one tissue retention blade and adapted to retain the tissue retention blade in the displaced position. Stabilization of a spinal segment is also provided by advancing a substantially concave orthopedic implant through an opening made in at posterior aspect of a disc space.
US08764802B2 Pedicle screw for intervertebral support elements
A pedicle screw for intervertebral support elements consists of a shaft and a head comprising at least two parts. The head is formed as a securing means for at least one support element. Each support element consists of a piece of a cable-like band and a cylindrical support body with an axial lumen containing the band. The band is securable outside end surfaces of the support body in the head. The head is formed with a contact surface via which a pressure stress can be exerted on the support body in the band direction, and indeed using the band and in cooperation with a further pedicle screw. A part of the head, which is firmly connected to the shaft at the one end of the latter, contains a base groove which is oriented transversally to the shaft and into which the part of the band to be secured or a connecting piece which contains the band can be introduced during the securing of the support element by means of a translatory movement in the direction of the shaft and fixed there.
US08764795B2 Tissue closure device and method
A device having a plurality of anchors configured to be driven into a tissue, and a closure element extending between the anchors and configured to urge the anchors from a first configuration in which the anchors are a first distance from each other, toward a second configuration in which the anchors are a second distance from each other, the second distance being less than the first distance, wherein the device is configured to maintain the anchors in the first configuration during a surgical intervention and to subsequently allow the anchors to be moved by the closure element toward the second configuration.
US08764788B2 Multi-layer coaxial vaso-occlusive device
A vaso-occlusive device includes inner, intermediate, and outer elements arranged coaxially. The inner element is a filamentous element, preferably a microcoil. The intermediate element is made of a non-metallic material, preferably an expansile polymer. The outer element is substantially non-expansile and defines at least one gap or opening through which the intermediate element is exposed. In a preferred embodiment, when the intermediate element is expanded, it protrudes through the at least one gap or opening in the outer element and assumes a configuration with an undulating, convexly-curved outer surface defining a chain of arcuate segments, each having a diameter significantly greater than the diameter of the outer element. The expanded configuration of the intermediate element minimizes friction when the device is deployed through a microcatheter, thereby reducing the likelihood of buckling while maintaining excellent flexibility. The result is a device with enhanced pushability and trackability when deployed through a microcatheter.
US08764787B2 Occlusion device and associated deployment method
An occlusion device for occluding a cavity defined by a body is provided, and includes first and second laterally-expandable portions each formed of a woven tubular fabric and having opposed proximal and distal ends. The first portion is insertable into the cavity so as to be substantially disposed therein upon lateral expansion thereof. A connective element tethers the distal end of the first portion and the second portion, and is cooperable therewith to form a collapsible assembly extending along an insertion axis. Retention members, operably engaged with each of the first and second portions and spaced apart about a laterally outward surface thereof, are adapted to engage the body, after insertion of the collapsed assembly, second portion-first, into the cavity, and subsequent lateral expansion of the first and second portions, so as to retain the assembly substantially within the cavity. An associated deployment method is also provided.
US08764783B2 Fluid absorbent surgical device for cannulas
A surgical instrument that absorbs fluid material on surfaces of a trocar is provided. The surgical instrument comprises a handle having at least two ends and an absorbent area at a first end of the handle. The absorbent area comprises a plurality of absorbent discs and a plurality of spacers.
US08764782B2 Phacoemulsification needle
A phacoemulsification needle having a hollow passageway terminates in a straight needle tip formed off-axis from the passageway, allowing the needle tip to move eccentrically when the needle is subjected to torsional or longitudinal vibratory motion. The tip may be flared or may be coextensive with the needle body. The aspiration passageway formed through the needle body may be formed off-axis from the needle body axis. The tip may also be angled with respect to the needle body. The inner and outer surfaces of the needle tip are roughened, as by sandblasting, to enhance the cutting effect of the tip when used with a non-longitudinal handpiece. The lip of each needle tip is polished to a high degree of smoothness and the edges of the tip are rounded to lessen the incidence of snags or cuts.
US08764781B2 Guarded surgical knife handle
A guarded surgical knife handle includes a handle portion with a blade holder, a chamber within the handle portion, and a slot. The guarded surgical knife handle also includes a guard having an open distal end slidably mounted within the handle portion that can slide longitudinally between an unguarded position and a guarded position. The guard is sized to surround the blade in the guarded position. The guarded surgical knife handle also includes a latch that latches the guard when the guard is slid into the guarded position and a first button that disengages the latch. The guarded surgical knife handle includes a bias member that forces the guard in a proximal direction to an unguarded position when the latch is disengaged along with a second button extending through the slot used to slide the guard in a distal direction into the guarded position.
US08764778B2 Biodegradable suture clip for joining bodily soft tissue
A biodegradable suture clip for joining bodily soft tissue is described. The suture clip has a pair of identical flexible compression strips which are identical and adapted to interlock with one another. Each strip has at least two piercing teeth having pointed free ends and opposed latch formations and also has at least two tooth latching guide openings for captive engagement with the piercing teeth. The openings are provided with latching guide ramps provided with arresting gripping formations wherein opposed latch formations of the teeth engage with associated ones of the gripping formations.
US08764775B2 Anastomosis device and related methods
Described are methods and devices relating to reconnecting the urethra and bladder after a radical prostatectomy, wherein the devices incorporate tissue approximating structure to maintain contact between a severed bladder neck tissue and a severed urethral stump tissue, preferably without the use of sutures.
US08764772B2 Occlusion device
An occlusion device for occluding a body vessel is provided. The occlusion device has a tubular expandable body having an interior side and an exterior side. A restricting ring is located around the exterior side of the tubular expandable body and collapses a portion of the tubular expandable body. The occlusion device is configured to move between an expanded state for occlusion within a body vessel and a collapsed state for delivery or retrieval of the device, and the device is configured to open radially to define the expanded state and to collapse along the longitudinal axis to define the collapsed state. A delivery assembly for an occlusion device and a method of constructing an occlusion device are also disclosed.
US08764771B2 Placing sutures
A suturing instrument is configured for to apply sutures to approximate, ligate, or fixate tissue in, for example, open, mini-incision, trans-vaginal, or endoscopic surgical procedures. The suturing instrument includes an elongate body member, a needle exit port, a needle receiving port, and a needle deployment mechanism. The suturing instrument eliminates the need for a preassembled needle and suture and reduces or eliminates the possibility of needle loss during suturing.
US08764770B2 Suturing device for organ
Provided is a suturing device for organ which sutures an internal organ in front and rear directions to do a suturing operation once by clenching and unclenching a hand of an operator so that the operator easily sutures the internal organ without requiring advanced training in surgical techniques and simply and conveniently sutures the internal organ only using one hand.
US08764768B2 Stapling device for closing perforations
Medical devices and systems for easily and reliably closing a perforation in tissue. One embodiment of a medical device for use with a scope includes a tubular member having a distal end, an exterior surface and an interior space. A carrier element extends along the exterior surface and around the distal end of the tubular member. An elastic band is positioned on the carrier element around the exterior surface of the tubular member. A staple is positioned within the interior space of a tubular member and includes first and second prongs which are spaced apart and translatable relative to one another. The carrier element is structured to deliver the elastic band beyond the distal end of the tubular member where upon the elastic band contracts and engages the staple to translate the first and second prongs towards each other.
US08764767B2 Cam lock burr hole plug for securing stimulation lead
A burr hole plug comprises a plug base configured for being mounted around a cranial burr hole. The plug base includes an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base. The retainer includes a retainer support, a slot formed in the retainer support for receiving the medical device, and a clamping mechanism having a movable clamping element and a cam configured for being rotated relative to the retainer support to linearly translate the movable clamping element into the slot, thereby securing the medical device. The retainer further comprises another clamping mechanism having another movable clamping element and another cam configured for being rotated relative to the retainer support to linearly translate the other movable clamping element, thereby laterally securing the retainer within the plug base.
US08764763B2 Procedure for repairing foot injury
A Lisfranc injury between a second metatarsal and medial cuneiform is repaired by gaining access to the injury site and placing two arm members of a novel drill guide around the two neighboring bones at the injury site, drilling a guide wire through the two bones guided by the drill guide to a desired depth, measuring the depth of the guide wire to determine the proper length for a bone screw for securing the two bones, drilling a cannulated drill bit into the two bones to a drill depth using the guide wire as a guide, and threading a bone screw into the two bones.
US08764762B2 Attachable instrument guide with detachable handle
An instrument guide with device coupler, a handle and one or more instrument guide lumens is detachably coupled to an orthopedic implant to facilitate drilling of the fastener holes or to facilitate insertion of self-tapping or self-dripping fasteners. The handle is preferably detachable to facilitate access to the instrument guide lumens. The device coupler detachably engages the implantable device and aligns the instrument guide lumens with the fastener openings on the device.
US08764759B2 Distal femoral trial with removable cutting guide
Various embodiment of the present invention provide a distal femoral trial that allows a surgeon to cut the central box geometry of a distal femur using an implant-shaped trial. The trial includes a cutting guide that is removable from the trial and adjustable with respect to the trial. The guide is intended to control the depth and direction of the cutting instruments used to prepare the femur for the a posterior stabilized implant.
US08764757B1 MIS TLIF systems and related methods
MIS TLIF systems and related methods. Implementations of distractor devices may include a first portion and a second portion where the second portion is slidably coupled over the first portion. A position of the second portion relative to the first portion may be adjustable through contacting a distractor latch coupled to the second portion with a plurality of teeth on a side of the first portion. The first portion may include a first pedicle screw pin on an end of the first portion opposing the second portion. The second portion may include a second pedicle screw pin on an end of the second portion opposing the first portion. The first pedicle screw pin and the second pedicle screw pin may be both configured to couple with a pedicle screw head. A length of the distractor device may be configured to be adjustable through sliding of the first portion.
US08764756B2 Single action anti-torque rod reducer
A rod reducing device includes an elongate member, a pair of jaw members, a sleeve having a cam pin, and an actuation lever. Translation of the cam pin along the inner surfaces of the jaw members pivotally moves the jaw members between a receiving position in which distal end portions of the respective jaw members are widened and an engaging position in which the distal end portions of the respective jaw members are move toward each other to engage the head of the bone screw. The actuation lever is movable between an open in which a distal end portion of the sleeve is disposed proximal of the distal end portions of the jaw members and a closed position in which the distal end portion of the sleeve is disposed distal of the distal end portions of the jaw members for reducing the connecting rod.
US08764751B2 Endosteal nail plate for fixing bone segments
An endosteal nail plate for fixing bone segments is provided. More particularly, there is provided an endosteal nail plate that can be made up of a single piece, or of multiple pieces, as desired. Additionally, the intramedullary nail utilizes a threaded slot on the body thereof, for engaging locking screws for fixation of the intramedullary nail within a bone of a patient.
US08764743B2 Deflectable catheter with hinge
A deflectable device, such as a catheter, is provided that includes a hinge that enhances the ability of the device to deflect or bend within a predetermined plane. The catheter comprises an elongated tubular catheter body having proximal and distal ends and at least one lumen extending therethrough. A distal segment is provided distal to the distal end of the catheter body. A tubular hinge is provided between the distal end of the catheter body and the proximal end of the distal segment. The hinge has an axis and at least one lumen extending therethrough. The tube includes at least one slot, and preferably a plurality of slots, extending part of the way through the hinge generally transverse to the axis of the hinge.
US08764740B2 Systems apparatus and methods for distributing coolant within a cryo-ablation device
Systems, apparatus and methods for dispersing a coolant along different portions of a supply tube of a cryo-ablation device which may be in the form of a linear ablation device or catheter probe or a balloon catheter. A supply tube includes multiple tubes that are in fluid communication with an inner space of a transmissive region or an inner space of an inflatable balloon. The tubes are coaxially arranged and extend to different lengths or to different locations such that the coolant is dispersed from different tubes at different axial locations. Annular apertures are defined by pairs of tubes and have different sizes. The tubes and arrangement thereof are structured to provide uniform or substantially uniform coolant distribution to provide uniform or substantially uniform cryo-ablation of surrounding tissue.
US08764738B2 Skin treatment device using pulsed electromagnetic radiation
The device includes a housing, a flash lamp arranged inside the housing, the housing having an opening through which electromagnetic energy originating from the flash lamp can be transmitted towards a skin surface. The housing includes a cavity adjacent to the flash lamp; at least one aeration orifice; and at least one mobile component in the housing, which can be displaced between a first so-called aeration position, in which the cavity communicates with the aeration orifice and a second so-called closed position, for which the cavity is closed in order to limit the light escaping from the opening. The mobile component can be formed by a housing portion that can close the cavity except for the opening, by moving towards a complementary housing portion
US08764737B2 Precise targeting of surgical photodisruption
Techniques, apparatus and systems for laser surgery including imaging-guided surgery techniques, apparatus and systems.
US08764736B2 Laser-induced protection shield in laser surgery
Techniques, apparatus and systems for laser surgery are described to provide protection of sensitive tissues from surgical laser pulses. For example, an ophthalmic surgical method may include determining a surgical target region in an eye, selecting a protection region between the surgical target region and a photosensitive tissue, estimating a damage-threshold of the photosensitive tissue and a protection-threshold of the protection region, applying preliminary laser-pulses to the protection region with parameters between the damage-threshold and the protection threshold to form a protection barrier, and applying surgical laser pulses to the surgical target region.
US08764733B2 Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
US08764732B2 Wound dressing
A method and apparatus are disclosed for dressing a wound. The apparatus comprises an absorbent layer for absorbing wound exudate, a liquid impermeable, gas permeable filter layer over the absorbent layer, a cover layer comprising at least one orifice and a first liquid and gas permeable transmission layer underlying the absorbent layer. The transmission layer is in fluid communication with the filter layer.
US08764730B2 Catheter apparatus and methods for treating vasculatures
A catheter apparatus may have a flexible shaft, guidewire lumens passing through the shaft, and a positioning device for positioning the guidewires relative to an external lumen. The positioning device may be an expansible scaffold covered with a retractable sheath. The positioning device may also be one or more balloons that are inflated through an inflation port in the shaft. The catheter apparatus may be operated by inserting a guide catheter into a vasculature with a chronic total occlusion, inserting the catheter apparatus into the guide catheter, and advancing the guidewires through the guidewire lumens and into contact with a chronic total occlusion. The positioning device may be activated before and/or between attempts to pass the guidewires through the chronic total occlusion to interrogate various parts of the chronic total occlusion.
US08764729B2 Frontal sinus spacer
Substance delivering spacer devices may comprise expandable reservoirs that are implantable in paranasal sinuses and other cavities, openings and passageways of the body to maintain patency and to provide sustained local delivery of a therapeutic or diagnostic substance. Delivery apparatus including elongate tubular members as well as shapeable distal portions and atraumatic tips are provided. Also provided are sinus penetrator devices and systems for performing ethmoidotomy procedures or for creating other openings in the walls of paranasal sinuses or other anatomical structures.
US08764725B2 Directional anchoring mechanism, method and applications thereof
An anchoring mechanism and method for anchoring a device within a biological conduit include an expandable element configured for retaining the device at a desired angle relative to a central axis of the biological conduit. A steering mechanism is preferably provided for orienting the device prior to operation of the anchoring mechanism. The anchoring mechanism and method are employed in drug delivery devices, brachytherapy devices or for anchoring a catheter or sheath to provide a working channel for reliable guidance of a wide range of tools to a target location within the body.
US08764718B2 Absorbent article
An absorbent article, especially an incontinence pad, having a length and a width extension, the length being greater than the width, and having absorbent core material, wherein the outer longitudinal edges of the absorbent material form three convex lobes (2, 3, 4), wherein a pair of folding lines (5) extend between the longitudinal ends of the middle one (3) of the three lobes (2, 3, 4), so as to divide the absorbent core material into a central portion (6) and a pair of longitudinal side portions (7), such that, when the article (1) is in use, the folding lines (5) are generally positioned so as to extend along the crotch area of the user, starting from the gracilis tendons and ending in the region of the perineum, whereby the side portions (7) may extend from the central portion (6) towards the user so as to form an arc shape as seen in a transversal direction of the article (1).
US08764713B2 Method of repositioning an injection port
A method of repositioning an injection port comprises positioning the injection port at a first location in a patient's body and extending fasteners of the injection port to substantially secure the injection port at the first location. The fasteners are then retracted to substantially unsecure the injection port from the first location in the patient's body. The injection port is then moved to a second location in the patient's body. The fasteners are then re-extended to substantially secure the injection port at the second location in the patient's body. The injection port includes a port body. The fasteners are integral with the port body. The fasteners may be selectively extended and retracted relative to the port body. For instance, the fasteners may be pivoted relative to the port body to transition between extended and retracted positions. The extension and retraction of fasteners may be provided through a port applier.
US08764708B2 MEMS device and method for delivery of therapeutic agents
Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient's eyeball.
US08764706B2 Disposable pen needle with re-use prevention features
A pen needle (521) for a drug delivery device (100) includes a hub (511) and a needle (502) fixedly connected to the hub (511). An outer cover (501) removably receives the hub (511) and the needle (502). A locking member (505) locks the hub (511) and the needle (502) in the outer cover (501). The hub (625) may have a colored portion (629) visible to the user to indicate that the needle (623) has been used.
US08764705B2 Balloon with integral segmented dilation elements
A balloon and method of making a balloon catheter is provided. The balloon for the balloon catheter may be made by slicing through an integral dilation element on a parison (10). The parison may then be stretched to spread the slices to form wider gaps (20). The gaps define separate dilation element segments (14), which may make the balloon more flexible.
US08764698B2 Arteriovenous access valve system and process
An arteriovenous graft system is described. The arteriovenous graft system includes an arteriovenous graft that is well suited for use during hemodialysis. In order to minimize or prevent arterial steal, at least one valve device is positioned at the arterial end of the arteriovenous graft. In one embodiment, a subcutaneous arteriovenous graft system is described. The system includes an arteriovenous graft having an arterial end and an opposite venous end with a first valve device positioned at the arterial end of the arteriovenous graft and a second valve device positioned at the venous end of the arteriovenous graft. The system also includes an actuator having an accumulator. The actuator is in communication with both the first valve device and the second valve device and is configured to cause each valve device to open or close simultaneously. The accumulator assists in maintaining a generally constant pressure when the actuator causes each valve device to close.
US08764696B2 Medical drainage devices with carbon-based structures for inhibiting growth of fibroblasts
Drainage devices for draining a fluid from a patient during treatment of a medical condition body are disclosed. The drainage devices comprise a body defining at least one conduit through the body from a distal end of the body to a proximal end of the body. The body comprises at least one carbon-based structure configured to inhibit growth of fibroblasts in the conduit when the fluid flows through the conduit. Example embodiments of the drainage device may include an ophthalmic shunt, a hydrocephalus shunt, an artificial mesh, an arteriovenous shunt, a thoracic catheter, and a central venous access device.
US08764693B1 Systems and methods for decompression and elliptical traction of the cervical and thoracic spine
A traction device comprises a frame, a first bladder portion, a second bladder portion, a spacer, and a pump. The first bladder expands in an outward direction a distance greater than in a transverse direction. The second bladder expands in an angular direction. The second bladder is positioned generally below and to the side of the first bladder. Upon expanding in the outward direction, the first bladder bears against the back of the user's neck. Upon expanding in the transverse direction, the first bladder applies an angular traction to the cervical spine. Upon expanding in the angular direction, the second bladder bears angularly against the back of the user's upper thoracic region.
US08764692B2 Knee brace with lightweight structure
A knee brace for the correction of abnormalities of the knee such as varus or valgus knee, or for the various forms of osteoarthritis, consisting of a support structure with a sole direction of development, that is to say it comprises a single upright (11) for the femoral area and a single upright (12) for the tibial area, these uprights (11, 12) being connected and hinged to a single articulated joint (13), which can be positioned close to one side of the knee, generally the outer side in the case of varus knee or the inner side in the case of valgus knee.
US08764689B2 Device, system and method for compression treatment of a body part
A device for compressive treatment of a body part includes a compression member, adapted to at least partly encircle the body part, and an actuation unit, arranged to tighten the compression member to provide a compressive force to the body part. The actuation unit includes an active material actuator. There is also disclosed a system comprising such a device and methods for its therapeutic, cosmetic and non-therapeutic use and operation.
US08764688B1 Therapeutic method and apparatus using mechanically induced vibration
A sleeve that provides mechanical stimulation to the arm to prevent bone density loss. A primary goal of this product is to prevent bone density loss that occurs during extended space travel. For one embodiment, only the predefined frequency specifications had to be met (between 40 Hz and 60 Hz). By meeting these frequencies for a duration of 30 minutes the product will theoretically prevent the loss of bone density. Additionally, clinical trials will need to be conducted before this product can be marketed. The product includes of several mechanical vibrators attached to a sleeve. The vibrators are small unbalanced-mass motors which are similar to those found in cell phones. The motors are encased in dome shaped housings designed to reduce lateral vibrations along the arm. The product is controlled using an Arduino board attached to the sleeve that actuates the motors. The motors, in turn, provide the specified frequency to the arm for 30 minutes. The spacing of the motor housings was determined from PEA simulations. This resulted in the motors being spaced 2 in apart along the arm at 90° increments around the axis of the arm. The controller has a display that allows for user interaction and includes a session timer. In addition, this product is contemplated for use in reducing muscle atrophy, eliminating bed sores, and treating other ailments that can result from sedentary behavior.
US08764687B2 Methods and systems for coupling and focusing acoustic energy using a coupler member
An exemplary system for coupling acoustic energy using an encapsulated coupler member comprises a display or indicator, a control system, a probe, and a coupler member. This invention provides a coupler member adjustably configured to perform at least one of (i) providing a standoff, (ii) focusing or defocusing energy, and (iii) coupling energy. An exemplary gel coupler member is configured to hold the shape of a lens geometry. In one aspect of the present invention, gel coupler member comprises water, glycerol, and polyvinyl alcohol, and exhibits an increased desiccation time and shelf life when compared to the prior art. The probe can comprise various probe and/or transducer configurations. In an exemplary embodiment, the probe delivers focused, unfocused, and/or defocused ultrasound energy to the region of interest. Imaging and/or monitoring may alternatively be coupled and/or co-housed with an ultrasound system contemplated by the present invention.
US08764686B2 Fetal movement information processing device and fetal movement information processing method
A fetal movement information processing device and method for accurately grasping and predicting the healthy development state of a fetus, namely, the well-being state of the fetus by adequately detecting and recording information on the fetal movement of a pregnant woman. The fetal movement information processing device comprises detected information storage means (20) for storing fetal movement detection signal detected by a fetal movement sensor (11) and detection day information associated with the fetal movement detection signal, pregnancy number-of-elapsed-days calculating means (38) for calculating the number of elapsed days from the fetal movement detection signals, fetal movement amount measuring means (54) for measuring the fetal movement amount per unit time from fetal movement signals read out from the detected information storage means, and displaying/outputting means (60) for displaying the fetal movement amounts acquired by the fetal movement amount measuring means and arranged in order of week of pregnancy.
US08764685B2 Biomedical interface pressure transducer for medical tourniquets
A biomedical interface pressure transducer which is useful for interposing between a limb or tissue and an occlusive band, tourniquet cuff or other biomedical apparatus in order to estimate the pressure and pressure gradient applied to a selected area of the limb or tissue is disclosed. The pressure transducer comprises a modified MEMS pressure sensor and a conformable semisolid body enclosed in a shear relief membrane which translates the pressure applied by the occlusive band to the modified MEMS pressure sensor mounted on a flexible substrate with patterned electrical interconnect tracks allowing the connection of the pressure sensor to digital communication and control circuitry.
US08764682B2 Measurement device and puncture device
Disclosed are a measurement device and a puncture device that prevent thermal loss and enable decreased cost in laser units. A laser unit (200) of a measurement device (100) is equipped with a lens barrel (210), a laser rod (220) disposed inside the lens barrel (210), a flash lamp (230) which is disposed opposite the laser rod (220) inside the lens barrel (210) and in which an inert gas is sealed inside a hard glass tube (231), and supports (241, 242, 243, 244), which are made from a material with thermal conductivity of 100 W/(mK) or more, at least parts of which are disposed outside of the lens barrel (210), and which support the circumferential surface of the hard glass tube (231) in a housing.
US08764679B2 Biopsy apparatus
A disposable tissue removal device comprises a “tube within a tube” cutting element mounted to a handpiece. The inner cannula of the cutting element defines an inner lumen and terminates in an inwardly beveled, razor-sharp cutting edge. The inner cannula is driven by both a rotary motor and a reciprocating motor. At the end of its stroke, the inner cannula makes contact with the cutting board to completely sever the tissue. An aspiration vacuum is applied to the inner lumen to aspirate excised tissue through the inner cannula and into a collection trap that is removably mounted to the handpiece. The rotary and reciprocating motors are hydraulically powered through a foot pedal operated hydraulic circuit. The entire biopsy device is configured to be disposable. In one embodiment, the cutting element includes a cannula hub that can be connected to a fluid source, such as a valve-controlled saline bag.
US08764675B2 Composite electrode
An electrode for applying electric fields to a patient includes a plurality of ceramic elements (e.g., ceramic discs) that are designed to be positioned against the patient's skin. Electrical connections are made to the ceramic elements (e.g., using a flex circuit). Temperature sensors (e.g., thermistors) are preferably provided at at least some of the ceramic elements to sense the temperature at the skin beneath the ceramic elements, so that appropriate action can be taken if an overtemperature condition is detected.
US08764664B2 Methods and apparatus for conformable medical data acquisition pad and configurable imaging system
A conformable medical data acquisition pad and configurable imaging system. The conformable pad may comprise a carrier base having a plurality of transceivers in operative association with an interconnection network that communicates with a computer system. The data acquisition pad may be constructed with a flex circuit and at least one ultrasound data collection device to carry out a variety of medical procedures. Different types of signal transmitting and receiving elements can be selected to provide ultrasound systems, including scalable capacitive micromachined ultrasound transducers arranged in a variety of configurations in combination with controlling electronics which interface with a translator board and software for signal processing. The resulting ultrasound data, such as a three-dimensional model, can be transmitted via an industry standard high speed bus to standard interfaces on various ultrasound systems.
US08764663B2 Method and apparatus for locating and distinguishing blood vessel
A apparatus and a method are disclosed for transmitting a signal directed to a blood vessel via a Doppler ultrasound waveform apparatus, receiving, by the Doppler ultrasound waveform apparatus, a reflected signal from the blood vessel; and determining, by a processing device, whether the blood vessel is an artery or a vein based on a blood flow velocity in the blood vessel.
US08764662B2 Ultrasound imaging system and method for temperature management
A temperature management system and a method of monitoring temperature in an ultrasound imaging system is provided. The system includes an ultrasound probe. The ultrasound probe includes at least one ultrasound transducer and a plurality of application specific integrated circuits. Further, the system includes at least one temperature sensing device disposed on at least one of the plurality of application specific integrated circuits. The temperature sensing devices are disposed in such a way that the sensing devices are in thermal contact with at least one heat producing region of the ultrasound probe.
US08764661B2 Echolocation data generation
Methods of probing a material under investigation using an ultrasound beam. Echolocation data is generated using a multi-dimensional transform capable of using phase and magnitude information to distinguish echoes resulting from ultrasound beam components produced using different ultrasound transducers. Since the multi-dimensional transform does not depend on using receive or transmit beam lines, a multi-dimensional area can be imaged using a single ultrasound transmission. In some embodiments, this ability increases image frame rate and reduces the amount of ultrasound energy required to generate an image.
US08764658B2 Ultrasound and microbubbles in ocular diagnostics and therapies
The present disclosure described methods, systems, and techniques for applying contrast-enhanced ultrasound to locate areas of blockage within retinal vessels and to break up clots that are causing damage. In addition to identifying the damaged area, the researchers anticipate that the initial image may serve as a baseline for monitoring the effect of treatment on the vessel, which may be achieved in multiple ways. The vibration effect of the ultrasound itself may suffice to dislodge clots. The microbubbles may also be coated or filled with medication, with ultrasonic shock waves activating the coating or causing mini explosions to release the medicine. Loading the microbubbles with a therapeutic agent, visualizing their presence at the diseased site using the ultrasound diagnostic mode, and then activating the microbubbles to release their contents at the targeted lesion could be a powerful and effective way to reverse occlusion without harming other areas of the eye or body.
US08764656B2 Sensing device of emotion signal and method thereof
The present invention relates to a sensing device of an emotion signal and a method thereof capable of recognizing and analyzing the change in emotion by collecting at least one of the bio signals and peripheral environmental signals, guiding the state of emotion to a user, and sharing emotion information with authorized persons and communicating it between them. The sensing device of the emotion signal according to the embodiment of the present invention includes a sensing signal processor that senses a plurality of bio signals and peripheral environment signals of a user; an emotion signal processor that generates emotion signals representing the emotional state of the user for each of the sensed bio signals and collects the emotion signals to generate an emotion index; and an emotion signal communication unit that optionally transmits the emotion signals and the emotion index to external authorized devices.
US08764655B2 Remote medical diagnosis device including bio-mouse and bio-keyboard, and method using the same
Disclosed herein are a remote medical diagnostic device that includes both a bio-mouse and a bio-keyboard, and a method using the same.
US08764652B2 Method and system for measuring and ranking an “engagement” response to audiovisual or interactive media, products, or activities using physiological signals
A system and method for calculating an engagement value by quantifying an amount that a user is acting without thinking considering brainwaves and a heart rate can be used to compare media based on an individual or a group of individuals. Events of the media can be contrasted and compared by the engagement value as well. Statistical measurements may be taken to improve media.
US08764648B2 Laparoscopic instrument and trocar systems and related surgical method
A trocar unit includes a flexible lateral wall defining a cavity and a longitudinal axis. A flexible first plate connects to the flexible lateral wall and is surrounded by the flexible lateral wall. The flexible first plate extends generally transversely to the longitudinal axis. Independent portals extend through at least the flexible first plate. The flexible first plate includes a rigid section attached around the periphery of the flexible first plate. The flexible first plate is spaced from the open distal end of the cavity and is positioned above an opening at a surgical site. A second plate is configured to fit securely within a portion of the flexible lateral wall and is disposed distally with respect to the flexible first plate. A second rigid section is attached around the periphery of the second plate.
US08764647B2 Foam port device having closed-end lumens
A surgical apparatus includes a seal anchor member. The seal anchor member includes a leading end, a trailing end, and at least one longitudinal port extending between the two ends. The at least one longitudinal port is dimensioned for reception of a surgical object. One end of the at least one longitudinal port is closed by a membrane, which can be pierced through by a sharp-pointed device. The at least one longitudinal port further includes at least one lip therein. The at least one lip is configured to establish a substantially sealed relation with the surgical object entered therethrough, thereby inhibiting the loss of insufflation gas between the at least one longitudinal port and the surgical object.
US08764646B2 Surgical expansion device
A surgical device for application in a treatment performed on the human or animal body with the aim of providing access to a surgical site in the body by exerting a force, upon expansion of the device at the location of the surgical site, on the organs and/or tissues at the surgical site, e.g. for mobilizing and/or supporting organs and/or tissues, the surgical device including an expansion structure, at least one fluid reservoir, and a conduit for conveying fluid from the reservoir to the expansion structure.
US08764645B2 Surgical access device and wound protector
An access device for use in a minimally invasive surgical procedure is disclosed. The access device is configured and adapted to be placed within a body opening to provide access to an underlying body cavity. The access device provides protection to the opening and minimizes contamination and the risk of possible infection.
US08764641B2 Plug device and endoscope
A portion of an outer periphery of a plug body of a forceps plug is cut out to form an arm having a shape along the circumferential direction of an outer peripheral surface of an opening. A tip portion of the arm is formed with a boss that protrudes toward the opening. An outer peripheral surface of the opening tip portion is formed with a cam groove for a forceps plug that guides the boss. The cam groove for a forceps plug is constituted by a cam groove for attachment that guides the boss 33 when the forceps plug is attached, a cam groove for locking that locks the boss, and a cam groove for removal that guides the boss when the forceps plug is removed. When the boss moves along the cam groove for removal, the deflection of the arm exceeds an elastic limit, and the arm breaks.
US08764637B2 Living-body observation system and driving method of the living-body observation system
A living-body observation system is provided with: an in-vivo observation apparatus including: an in-vivo information acquiring section; a power source section; a magnetic field detection section that detects a magnetic field from outside and outputs a detected result as an electric signal; and a power supply section that controls a supply state of driving power supplied to the in-vivo information acquiring section, and the operation of the in-vivo information acquiring section, based on the electric signal; and a magnetic field generating section that is disposed outside the in-vivo observation apparatus and generates the magnetic field, wherein the power supply section includes a control section that controls the operation of the in-vivo information acquiring section of the in-vivo observation apparatus.
US08764636B2 Electronic endoscopic apparatus
An electronic endoscopic apparatus of the present invention can improve the usage efficiency of a circuit of a control section therein and can improve the reliability of operations of the circuit. The electronic endoscopic apparatus is an electronic endoscopic apparatus having multiple operation modes to be executed exclusively, the apparatus internally including an FPGA 1 that internally includes a CPU 10 and peripheral circuits and controls the execution of the operation modes and a switching request detecting section that detects a request for switching to the operation mode to be executed, wherein the internal configuration of the FPGA 1 is changed based on the detection result by the switching request detecting section.
US08764632B2 Endoscopic device and system
An endoscopic system may include a catheter or tubing and at least one optical sensor disposed along the catheter or tubing and configured to capture image information from a body lumen when disposed within the body lumen and activated. The system may further include an untethered module operatively arranged with the at least one optical sensor and configured to store or transmit image information captured by the at least one optical sensor. The catheter or tubing, at least one optical sensor and module may be portable during use.
US08764627B2 Penile prosthesis
A male impotence treatment apparatus comprises an adjustable prosthesis device implanted in an impotent patient. The prosthesis device engages the corpus cavernosum or penile tissue of the patient to provide flaccid or erect state of the penis. An implanted adjustment device is adapted to adjust the prosthesis such that the penis can be temporarily erected. The prosthesis is preferably controlled with a remote control and an implanted powered operation device, which may include servo means, operates the adjustment device.
US08764623B2 Reproductive infusion device
A reproductive infusion device for collection of semen for in-home insemination. The device features a collection vessel having a collection cavity defined by a sidewall which communicates through an elongated member extending therefrom. The collection vessel removably engages coaxially with an injection component to transfer collected semen thereto. A plunger engageable with an axial cavity of the injection component is provided for vaginal deposit of collected semen.
US08764619B2 Brachytherapy fiducial needle fixation system and method
A mechanism to facilitate the insertion of radioactive sources/source strands into soft tissue, such as breast tissue, and a method that utilizes this mechanism with the goal of improving the reproducibility of the procedure and ensuring that the sources are reliably and consistently inserted in an exact position per a patient prescription treatment plan from patient to patient as well as improve the ease-of-use of the device and procedure are provided.
US08764618B2 Clampless bar mechanism for a paper bag bottoming mechanism
A paper bag bottoming mechanism having a bottoming drum having a first end, a second end, and a sidewall disposed therebetween, a bar affixed to the bottoming drum, the bar having a first end and a second end, a first guide block attached to the first end of the bar and a second guide block attached to the second end of the bar, a first slideable finger attached to the first guide block and a second slideable finger attached to the second guide block, and a first actuating mechanism communicating with the first slideable finger for actuating the first slideable finger and a second actuating mechanism communicating with the second slideable finger for actuating the second slideable finger. Also disclosed is a method for making a using a clampless bar mechanism.
US08764616B2 Systems and methods for a hill training apparatus for a bicycle trainer
Described is a bicycle trainer with a hill training apparatus that enables bicyclists to simulate uphill riding (incline), downhill riding (decline), and hill resistance, or lack thereof. The hill training apparatus also provides for correct body positioning while riding uphill or downhill and with or without resistance. Riding on a trainer with correct body positioning provides for improved training.
US08764614B2 Center pull cable handle apparatus
A center pull cable handle apparatus includes a length of hollow cylindrical steel tube. An outer grip layer is provided on the cylindrical tube. The grip layer and the tube each have a wall opening. A length of aircraft cable having a first cable end extends through the wall opening and is crimped in position inside the steel tube with a cable nut. A connector is provided on an opposite cable end. A length of a soft flexible tubing surrounds the cable between the grip layer and the connector. When a user grasps the handle the first cable end is located inside the grasp of the user and said cable and tubing pass between two fingers of the user.
US08764613B1 Hand therapy exercise tools, and kit of components
A kit of components of a multi-functional group of hand/forearm exercise tools wherein each tool permits the user to strengthen one or more muscles associated with the hand/forearm of the user, and/or to increase radial and ulnar deviation and forearm pronation and supination, or permits the user to mimic a functional task, such as turning a door knob, opening a bottle cap, inserting and turning a key, turning and tightening a nut, and turning and tightening a bolt.
US08764612B2 Play gyms and methods of operating the same
Play gyms and methods of operating the same are disclosed. A disclosed example includes a floor mat dimensioned to be positioned within a play yard and/or a bassinet. It also includes a play gym to suspend an object above the mat when the mat is positioned in the play yard and/or the bassinet, and at least one connector to couple the play gym to the mat when the mat is removed from the play yard and/or the bassinet.
US08764611B2 Trampoline game
A trampoline game has a trampoline with a trampoline frame and a trampoline bed. The trampoline bed is connected to the trampoline frame by a plurality of springs. A gun has an infrared emitter emitting an infrared signal. A target has one or more infrared receivers capable of receiving a signal from the infrared emitter of the gun. A second gun also has an infrared emitter emitting an infrared signal, and the target is capable of receiving an infrared signal from the second gun. A bounce sensor can be used for sensing user bounces. The bounce sensor outputs data which could be sent to a microprocessor. Defined game parameters may be stored in memory programmed into a microprocessor that receives data.
US08764610B2 Trampoline equipped with a protective circular net
A trampoline includes a frame, a protective circular net and a jumping portion. The frame has a circular base rack, a plurality of legs and circular net support racks respectively at two sides of the circular base rack. The jumping portion is located in the circular base rack and includes a flexible mat and a plurality of elastic support members having one end coupled on the flexible mat and another end fastened to the circular base rack. The protective circular net is hung on the circular net support racks. The protective circular net is held by a reinforced coupling portion which includes a holding section fastened to the flexible mat and a retaining section threaded through by at least one tightening member. The protective circular net has a lower edge with a plurality of apertures formed thereon threaded through by the tightening member to couple with the retaining section.
US08764609B1 Exercise enhancement machine
An exercise machine includes a frame, an adjustable seat assembly, a means for slidably adjusting the seat assembly axially along the frame, a means for pivotally adjusting the seat assembly between a generally upright position and a recumbent position, an adjustable resistance assembly which includes rotatable pedals, and a display panel with means for providing omnidirectional positionability of the display panel. The exercise machine allows a user thereof to simultaneously perform crunching exercises and actively engage the adjustable resistance assembly in order to allow the user to reach the highest, optimized levels of cardiovascular fitness and calorie burning during a physical exercise interval.
US08764603B1 Planetary gear train of automatic transmission for vehicle
A planetary gear train of an automatic transmission for a vehicle may include: an input shaft, an output shaft disposed in parallel with the input shaft, a first planetary gear set disposed on the input shaft, a second planetary gear set disposed on the output shaft, a third planetary gear set disposed on the output shaft, three transfer gears forming an externally-meshed gears, and frictional elements selectively interconnecting rotation elements or selectively connecting the rotation elements to a transmission housing. The first planetary gear set includes a first ring gear, a first planet carrier, and a first sun gear. The second planetary gear set includes a second sun gear, a second planet carrier, and a second ring gear. The third planetary gear set includes a third sun gear, a third planet carrier, and a third ring gear.
US08764602B2 Planetary gear train of automatic transmission for vehicles
A planetary gear train of an automatic transmission may include a first planetary gear set including a first ring gear directly connected to a first shaft, a first planet carrier, and a first sun gear, a second planetary gear set disposed on a second shaft and including a second sun gear receiving an inverse rotation speed from the first planet carrier, a second ring gear selectively connected to the second shaft, and a second planet carrier, a third planetary gear set including a third sun gear directly connected to the second shaft, a third ring gear selectively connected to the first sun gear, and a third planet carrier directly connected to the second planet carrier and directly connected to an output gear, three transfer gears interposed between rotation elements, and five frictional elements selectively interconnecting the rotation elements or selectively connecting the rotation elements to a transmission housing.
US08764595B1 Vehicle power transmission apparatus
In a vehicle that includes an auxiliary transmission mechanism where a high-speed range and a low-speed range are switchable, a carrier of an auxiliary transmission mechanism is coupled to a motor-generator to allow power transmission. When switching from the high-speed range to the low-speed range, the motor-generator increases a rotational speed of the carrier such that a rotational speed of a low-speed range piece is synchronized with a rotational speed of an input shaft. When switching from the low-speed range to the high-speed range, the motor-generator increases a rotational speed of the carrier such that a rotational speed of an output shaft is synchronized with a rotational speed of the input shaft. This allows range switch with a reduced gear change shock even while the vehicle is running.
US08764593B2 Sound-damping unit for a sprocket, and sprocket
A sound-damping unit for a sprocket has a mounting foot for connection to a sprocket and an elastic body placed on the mounting foot that is suitable for cushioning a chain running onto the sprocket. The elastic body is provided with a protective cap or protective layer. A sprocket according to the invention includes a circular sprocket disc having a number of teeth and tooth gaps in the circumferential direction. The sprocket is equipped with at least one sound-damping unit that is configured to reduce the noise upon a chain running onto said sprocket. The sound-damping unit is at least one sound damping unit as above.
US08764591B2 Ballistic arrow
A hunting arrow having an arrow shaft with a front end and a back end. The hunting arrow has at least one arrow blade attached to the arrow shaft, and has a closed position and at least one open position. The at least one arrow blade is substantially flush with the arrow shaft when in the closed position, and extends radially outward from the arrow shaft when in an open position. In addition, the hunting arrow has an arrow tip that is attached to the front end of the arrow shaft and is capable of moving longitudinally toward or away from the arrow shaft. The arrow tip is operatively engaged with the at least one arrow blade so that the arrow tip opens and closes the at least one arrow blade by moving relative to the arrow shaft.
US08764589B1 Extended flight system for an arrow
An extended flight system for extending the flying distance and improving the accuracy of an arrow when shot from a bow has a shaft first end having a threaded cavity for attaching a standard arrowhead. The shaft second end has a threaded rod for attaching a standard arrow shaft. The system has fletching located on the shaft exterior surface with fins or vanes resembling a shape of a triangle. The fins or vanes are located at an even distance from each other. A fin first end originates close to the shaft middle and a fin second end terminates close to the shaft second end. The arrowhead is attached to the shaft first end. The arrow shaft is attached to the shaft second end. A length of an arrow is extended upon installation of the system an equivalent of about the shaft length.
US08764588B2 Illuminated game-playing apparatuses and games
A game-playing set including a striking device and a ball, and games for playing therewith, are disclosed. The ball includes a hollow spherical translucent outer shell and a smaller inner object loosely disposed within the outer shell. The inner object includes a first illumination element and a first inertia switch. The striking device includes a hollow translucent tube, a second illumination device rigidly disposed within the tube, and a second inertia switch. The first inertia switch is triggered by impact of the inner object against the outer shell to cause illumination of the first illumination element and the second inertia switch is triggered by an externally-applied impact against the tube to cause illumination of the second illumination element.
US08764587B2 Multi-use golf device
A multi-use golf device is able to be used as a golf tee and as a divot repair tool. The multi-use golf device includes two portions that move relative to one another to change a configuration of the multi-use golf device. In a first configuration the multi-use device is generally extended and can hold a golf ball above a ground level. In a second configuration two portions of the multi-use golf device can be positioned near each other to repair a divot in a golf course putting green.
US08764585B2 Dual core golf ball having a shallow “positive hardness gradient” thermoplastic inner core and a steep “positive hardness gradient” thermoset outer core layer
A golf ball including a highly-neutralized thermoplastic inner core layer having a geometric center hardness less than a surface hardness to define a first hardness gradient, an outer core layer formed from a homogenous thermoset composition and having an interior hardness substantially less than an outer surface hardness to define a second hardness gradient, an inner cover layer, and an outer cover layer. Both the first and second hardness gradients are positive and a slope of the second hardness gradient is greater than a slope of the first hardness gradient to define a shallow hardness gradient inner core and a steep hardness gradient outer core layer.
US08764584B2 Multi-piece solid golf ball
A multi-piece solid golf ball comprising a core, an envelope layer encasing the core, an intermediate layer encasing the envelope layer, and a cover which encases the intermediate layer and has formed on a surface thereof a plurality of dimples, wherein the core is made primarily of a rubber material and has a diameter of at least 31 mm, the envelope layer and intermediate layer are each made primarily of the same or different resin materials and the cover is made primarily of polyurethane; intermediate layer and cover have an optimized thickness relationship; the core, envelope layer, intermediate layer and cover have optimized hardness relationships; and the core surface and core center have a large hardness difference therebetween. The golf ball has excellent flight performance and controllability acceptable to professionals and other skilled golfers, while also having excellent durability to cracking upon repeated impact and excellent scuff resistance.
US08764579B2 Golf club head
A hollow golf club head according to this invention includes a face portion, a crown portion, and a sole portion, and is formed by connecting a plurality of shell members to each other. This golf club head includes a rib which is provided in the sole portion and used to adjust an impact sound. The plurality of shell members are divided using at least the rib as a boundary. The plurality of shell members include a rib forming shell member including a sole portion forming portion which forms part of the sole portion, and a rib forming portion which stands upright from the end of the sole portion forming portion and forms the rib.
US08764578B2 Grooves of golf club heads and methods to manufacture grooves of golf club heads
Embodiments of grooves of golf club heads and methods to manufacture grooves of golf club heads are generally described herein. Other embodiments may be described and claimed.
US08764568B2 Game notification systems and methods
Systems and methods to provide game notifications are described. In some embodiments, a method receives an identifier for a player of a first multiplayer game and obtains multiple notifications using the identifier for the player. The multiple notifications are associated with at least one other multiplayer game. The method further determines a display order for displaying the plurality of notifications in a user interface for the first multiplayer game. The multiple notifications are transmitted to a device associated with the player in the display order and displayed in the user interface for the first multiplayer game in the display order.
US08764565B2 Apparatus and method of audio reproduction
A wearable loudspeaker unit comprises a loudspeaker, an audio reproduction processor, a wireless communications unit operable to communicate wirelessly with a base unit using a protocol that distinguishes the wearable loudspeaker unit from any other wearable loudspeaker units in communication with the base unit, and a user input interface operable to select one of a plurality of wearable loudspeaker unit wearing positions on a user's body; and the wireless communications unit is operable to transmit the selected wearing position of the wearable loudspeaker unit to the base unit, and is operable to receive audio data corresponding to the selected wearing position of the wearable loudspeaker unit from the base unit, and the audio reproduction processor is operable to output the received audio data through the loudspeaker.
US08764563B2 Video game superimposing virtual characters on user supplied photo used as game screen background
A feature image area that has a similar feature (e.g., quadrangular outline) is extracted from an original two-dimensional image photographed by a player. When a game has started, the original two-dimensional image is displayed as the background of a game stage, and a target character 4 is caused to appear or disappear from the extracted feature image area at a random appearance frequency and a random appearance speed. When the player has touched the target character 4, points are added to the score of the player.
US08764561B1 System and method for providing targeted recommendations to segments of users of a virtual space
Targeted recommendations may be provided to specific user segments. The users may be segmented on or more user parameters that facilitate targeted provision of recommendations to the individual segments of users. A recommendation may prompt a user to take a recommended action in the game.
US08764558B2 System and method for betting on a participant in a group of events
A method of managing bets includes receiving first types of bets and second types of bets. Each first type of bet comprises a bet that the number of units earned by a participant in a plurality of events will fall within a first range of numbers. Each second type of bet comprises a bet that the number of units earned by the participant over a course of a plurality of events will fall within a second range of numbers. The total number of units earned by the participant is determined based on the positioning of the participant in each event. The method includes determining whether the first or second type of bets are winning bets. A betting pool is determined based on the total amounts associated with the first and second types of bets. A payout is determined based on the betting pool and the total amounts of the winning bets.
US08764557B2 Gaming system and method for providing an offer and acceptance game with progressive awards
A gaming system for providing a progressive award in association with an offer and acceptance game.
US08764556B2 Method and system for providing real time sports betting information
The present invention is directed toward a method and system for providing sports betting information, in real time, utilizing a standard Internet connection on a computer to display the odds from a plurality of sports books. The system provides its users with a line seeker alert, a major line move alert, a bet tracker, and a fully customizable display. A method of gaining real time sports betting information without the use of a web browser, through the use of a separate program written in the C++ programming language is disclosed.
US08764554B2 Customized enhancement system
A computer-implemented method of creating enhancements in a computer game for a recipient experiencing a performance, the method including: selecting an enhancement to apply to a recipient; modifying the enhancement; and applying the modified enhancement to the recipient, wherein the modified enhancement is effective for a fixed duration of time proportional to the time spent by the recipient experiencing the performance. Keywords include MMO, buffs, packages and performance.
US08764552B2 Gaming system, gaming device and method for providing a player an opportunity to win a designated award based on one or more aspects of the player's skill
In various embodiments, the gaming system, gaming device, and method disclosed herein maintains a designated award which is associated with a variable score for a skill-based game. In one such embodiment, the gaming system enables a player to play a game, wherein the gaming system forms a score for the player. The player's formed score is based on zero, one or more inputs made by the player during the play of the skill-based game (i.e., which tends to measure one or more aspects of that player's skills). If the player's score does not reach the variable score associated with the designated award, the gaming system modifies the variable score associated with the designated award of that skill-based game. If the player's score reaches or exceeds the variable score associated with the designated award, the gaming system provides the player a designated quantity of opportunities to win the maintained designated award.
US08764551B2 Gaming machine, and control method of same
A gaming machine 1: variably displays a plurality of symbols on a lower image display panel 141 in response to an external input; randomly determining symbols 501 to be rearranged on the lower image display panel 141; determining one of game results based on the symbols 501 randomly determined; execute a common indication effect common to all the game results; and after common indication effect is executed, executes an individual indication effect according to the game result determined while the symbols are variably displayed.
US08764548B2 Gaming system, gaming device, and method for providing a directional symbol evaluation game
In one embodiment, a gaming system which may randomly generate a plurality of directional symbols. Each directional symbol may have an input direction and an output direction. The gaming system may analyze the generated directional symbols to determine whether any formed sets, chains or sequences of compatible directional symbols are associated with any awards. More specifically, the gaming system may determine whether to form any sets of compatible directional symbols based on if one or more input directions of one or more of the generated directional symbols are compatible with one or more output directions of one or more of the generated directional symbols. The gaming system then may determine and may provide a player an award based on one or more of any formed sets of compatible directional symbols.
US08764547B2 Method of gaming, a gaming system, and a game controller
There is disclosed a gaming system comprising a display 54, a symbol selector 623, a symbol evaluator 625 and a symbols modifier 626. The symbol selector 623 is arranged to select a plurality of sets of symbols for display on the display. The symbol evaluator 625 is arranged to determine whether the displayed symbols include any winning symbol combination. The symbol modifier 626 is arranged to, only upon a determination that the displayed symbols do not include any winning symbol combination, repeatedly apply a modification rule to at least one of the plurality of sets of symbols until the displayed symbols include any winning symbol combination.
US08764546B2 Electronic gaming and/or gambling machine
The present invention relates to an electronic gaming and/or gambling machine, in particular to a slot machine which is coin operable or is operable by monetary equivalents, comprising a display apparatus for the display of at least one game and optionally additional information, with the display apparatus having at least a first and a second screen on which at least one screen display, preferably a main game, and one second screen display, preferably a bonus game and/or additional information, can be displayed as well as a control panel for the actuation of the gaming and/or gambling machine. In accordance with the invention, the electronic gaming and/or gambling machine is characterized in that a switching device is provided which is actuable by a machine user by an input device for the switching of the first screen representation from the first screen to the second screen and of the second screen representation from the second screen to the first screen or to a further screen and/or vice versa.
US08764543B2 Method and system for playing a networked bingo game
Embodiments of the present invention provide methods, systems and programs for conducting a game of bingo, comprising an enrollment process in which at least one player enrolls to join a team of players to participate in the bingo game. Virtual players may be generated to join the team of players. Bingo indicia are drawn and compared to the players' (participating or virtual) bingo cards and an ending process is triggered when an ending pattern is formed on a bingo card.
US08764542B2 Game of chance utilizing wheels with parlay and progressive jackpot options
A game of chance and a method of playing a game of chance with a unique format and innovative wagering options, including parlay and progressive betting. At least one player must place at least one bet for the game to commence. Wagers can be placed on one event or multiple random events occurring simultaneously. Winning payouts are calculated based on the odds of the single event or the cumulative odds of multiple simultaneous events. The progressive bet can only be placed if another wager is simultaneously made, and is paid out as a separate bet. Once commenced, the game incorporates a plurality of random event generators to generate outcomes, which are paid out depending on predetermined payout odds. This game and method would be well suited for casinos in table, hybrid or electronic formats. This game could be played as a board game, a video game or a machine game.
US08764539B2 Gaming system, apparatus and method with a player decision field for providing interactive game results
A system, apparatus, and method are disclosed wherein a decision field is displayed having a number of result tokens spaced apart at different locations about the decision field, with each result token displaying a respective potential result. A decision point is also displayed within the decision field. This decision point is associated with two or more direction options which are preferably graphically depicted along with the decision point, and the player is enabled to make a direction input to select one of the direction options.
US08764537B2 Wagering game with symbols collection
Wagering game terminal and method of operating same are disclosed in which players collect symbols and/or symbol combinations that are indicative of a randomly selected outcome. The symbols and/or symbol combinations may be collected anytime they appear on the wagering game terminal, or they may be collected only if they appear in a certain manner or at a certain time. Players who manage to complete a predefined collection of symbols and/or symbol combinations are awarded a special event game, such as a bonus game, a jackpot, and the like. The players may carry over the symbols and/or symbol combinations they have collected across multiple gaming sessions and multiple gaming terminals. In this way, the players may retain the benefit of their previous gaming experiences.
US08764535B2 Video game where players compete to occupy areas
If an area in which a character has been already placed by a player in another team is selected from the areas displayed in a game field display part on a top screen and a player point count corresponding to Oshikura at the bottom of as PP selection part is selected, a comparison is made between a player point count that was selected by a player at the placement of the currently placed character and a player point count that was selected by a player who will place a new character. Then, the character related to a player having more player points is determined as the character to be placed in the area. Accordingly, more competitive game elements are realized in a game that uses multiple areas.
US08764530B2 Video game processing apparatus and video game processing program
A video game processing apparatus for controlling progress of a video game is provided. It is determined whether a predetermined command is effectively received for a predetermined number of times or more or not when a predetermined period of time is measured from a time when a time measuring start condition is satisfied. A specific process corresponding to the fact that the predetermined command is effectively received for the predetermined number of times is carried out in a case where the predetermined command is effectively received for the predetermined number of times. In this case, it is confirmed whether an effective reception number reaches the effective reception upper limit number or more when the predetermined command is received, and it is determined that the predetermined command is effectively received in a case where the effective reception number does not reach the effective reception upper limit number.
US08764529B2 Arrangement and method to sense flow using mechanical stress microsensors
A sensor module includes a MEMs sensor device and a processing circuit. The MEMs sensor device is operable to determine a fluid flow induced mechanical force on a first flow control device connective element. The processing circuit is operably coupled to receive fluid flow induced mechanical force information based on the determined fluid flow induced mechanical force. The processing circuit is configured to generate a fluid flow measurement value based on the fluid flow induced mechanical force information and position information representative of a position of a flow control device coupled to the first flow control connective element.
US08764527B2 Method and apparatus for providing cooling air to equipment
At least one aspect of the invention is directed to a ventilation device. The ventilation device includes a frame configured to be mounted to a barrier, and a plurality of air moving devices configured to be coupled to the frame and configured to draw air from a first side of the barrier to a second side of the barrier. The ventilation unit further includes a control device coupled to the plurality of air moving devices and configured to detect an out of tolerance condition of one of the plurality of air moving devices and control another one of the plurality of air moving devices to increase airflow though the another one of the plurality of air moving devices in response to the out of tolerance condition.
US08764525B2 Poultry neck meat harvester and method for mechanized harvesting of poultry neck meat
A poultry neck meat harvester for mechanized harvesting of neck meat from a poultry body is adapted to be arranged along the path of a poultry body conveyor having at least one product carrier for supporting a poultry body and conveying the poultry body in a direction of conveyance. The harvester includes one or more neck positioning devices, each adapted to receive and position the poultry neck portion of a poultry body that is supported by a product carrier, a neck conveyor with neck positioning devices adapted to convey each neck positioning device in a manner that is synchronized with a product carrier so as to allow receipt of the poultry neck portion while the poultry body is supported by the product carrier, a neck meat cutting member adapted to cut loose the neck meat from the neck vertebrae while the neck portion is received and positioned by the neck positioning device.
US08764524B2 Tenderizing machine for tenderizing pieces of meat
The invention relates to a tenderizing machine for tenderizing pieces of meat, the machine comprising a first tenderizing roller (1) rotating about a first axis (3) supported in a fixed position in a structure (51), a second tenderizing roller (2) rotating about a second axis (4) parallel to said first axis (3) and movably supported in said structure (51) with the possibility of being separated from the first axis (3) against the force of antagonist means due to the effect of the passage of the pieces of meat between said first and second tenderizing rollers (1, 2), and drive means for rotating the first and second tenderizing rollers (1, 2) in opposite directions comprising a first motor (5) operatively connected by means of a first mechanical transmission (7) to rotate the first tenderizing roller (1), and a second motor (6) operatively connected by means of a second mechanical transmission (8) to rotate the second tenderizing roller (2).
US08764522B2 Dental sharpening device
A one-piece hand-held sharpening device for dental instruments. The device is a sharpening stone having a continuous abrasive surface, with a uniform overall thickness, and generally corresponding flat longitudinally rectangular top face and bottom face surfaces. One side surface contains at least two longitudinal radius grooves and the opposite side face has rounded edges where it abuts the top and bottom surfaces. From either side view, it presents as an isosceles trapezoid with the top and bottom surfaces in parallel, both end surfaces with equal dimensions, and extending at equal angles from the end of the bottom surface to the end of the top surface. During sharpening, the upper end surface is aligned in parallel with a horizontal work surface. In other sharpening operations, each of the radius grooves allows proper sharpening of a different sized curette toe and the rounded edges permit sharpening of instruments with concave surfaces.
US08764520B1 Vacuum buffer assembly
Disclosed are improvements to a high speed power buffer assembly provided with a dust evacuation system. The assembly includes a hood depending from the chassis to encircle the high speed rotating buffer pad, a peripheral skirt depended from the chassis, a dust collection aperture adjacent the buffer penetrating the hood for the outlet of dust to the exterior of the hood, a curved dust collector chute, aligned and in communication with the dust collection aperture, and a dust collection bag, communicated with the dust collector output. The skirt has inclined grooves to co-act with the buffer pad to entrain air from the outside of the skirt to the inside. Given the arrangement of the foregoing features, the dust evacuation system can operate without the use of a vacuum pump.
US08764516B2 Hand held machine for grinding and like operations
A hand held machine for grinding and like operations, includes a housing, a motor mounted in the housing and which rotates an axle connected to a tool carrying mechanism, and a front bearing arrangement provided between the housing and the axle, including a front bearing, and a vibration insulator which is resilient to radial displacement of the axle. The vibration insulator includes at least one resilient element located between the housing and the front bearing. The machine further includes an adjustment mechanism interacting with the at least one resilient element for adjustment of the resilience of the resilient element.
US08764515B2 Component machining method and assembly
An example component machining method includes immersing a surface of a component within a fluid during a machining process. The method heats the surface during the machining to vary the machining process at the surface relative to other surfaces of the component.
US08764500B2 Outboard motor control apparatus
In an apparatus for controlling operation of an outboard motor having an engine to power a propeller, a transmission being selectively changeable in gear position to establish speeds including a first speed and second speed and transmitting power of the engine to the propeller with a gear ratio determined by established speed, and a trim angle regulation mechanism regulating a trim angle through trim-up/down operation, the transmission is controlled to change the gear position from the second speed to the first speed when the second speed is selected and a throttle opening change amount is at or above a predetermined value; and the trim angle regulation mechanism is operated to start the trim-up operation based on engine speed. With this, the transmission can be appropriately controlled to suppress the decrease in boat speed caused by change of gear position, thereby mitigating an unnatural feel given to the operator.
US08764496B2 Airbag electrical connector for improved contact reliability
Provided is a technique for improving connection reliability. A contact part that contacts with a detecting male contact is formed in a detecting collision spring piece. The detecting male contact includes a contact surface that contacts with the contact part. The detecting collision spring piece is elastically deformed in advance so that a gap is formed between the contact part and the contact surface when the contact part is opposed to the contact surface in a height direction. When an elastic deformation force that elastically deforms the detecting collision spring piece is released, the contact part contacts with the contact surface with collision against the contact surface due to a spring restoring force of the detecting collision spring piece. A locus of the contact part just before the contact part collides with the contact surface is oblique with respect to the contact surface when seen from a mate direction.
US08764491B2 Plug connector having an improved housing and method of making the same
A plug connector (100) includes a paddle board (21) and a housing having a first and a second housing portions (11, 12). The first housing portion includes a first side wall (1111) defining a first channel (112a), a second side wall (1112) defining a second channel (112b), and a cavity (13) defined between the front portion of the first side wall and the second side wall. The first channel has a rear portion exposed outwardly of the cavity for guiding the paddle board. The second housing portion is engaged with the first housing portion along a left-to-right direction to be in alignment with the second side wall for positioning the paddle board between the first and second housing portions.
US08764490B2 Relay connector, module, module device, and luminaire
According to one embodiment, a relay connector connects two input connectors respectively mounted on mounting surfaces of two substrates, ends of which are arranged to be opposed to each other. The relay connector includes a relay connector main body and relay terminals. The relay connector main body includes a substrate regulating section interposed between the ends of the two substrates and set in contact with the ends of the two substrates to form a space between the ends of the two substrates. The relay terminals project from both ends of the relay connector main body to be connected to the input connectors.
US08764482B2 Female-type metal terminal fitting
A connector provided with a female-type metal terminal fitting, includes a case portion including a bottom plate portion, first and second side plate portions, and an upper plate portion, a lance engaging portion formed at a rear end portion of the upper plate portion so as to engage with a lance, a biasing portion integrated in the case portion, a wire connecting portion provided so as to be extended to a rear side of the case portion, and a spring supporting plate portion laminated on an inner face of the upper plate portion. A rear end portion of the spring supporting plate portion is recessed toward inside of the case portion further than the rear end portion of the upper plate portion. The biasing portion is extended from the spring supporting plate portion.
US08764481B2 Direct mount connector terminal and direct mount connector
The present invention is to provide a direct mount connector terminal and a direct mount connector for improving reliability of connection thereof. The direct mount connector terminal is locked to a connector housing with a lance of the connector housing. The direct mount connector terminal includes an electrical connection portion extending toward a connection direction of a mating terminal, a bent portion connected to and bent with respect to the electrical connection portion, a parallel portion connected to the bent portion and parallel to the electrical connection portion, and a locking portion disposed on the parallel portion and to be locked to the lance of the connector housing.
US08764480B2 Cover for cable connectors
A cover and a system of covers for placement in sealed relation over a connector or a pair of connectors that is or are adapted to terminate a cable or splice together a pair of cables. The covers include a cable end that sealingly receives a cable therein, an elongated body that provides secure cover to a cable connector, and an end that abuts a bulkhead or sealingly engages with a second cover when used in a splicing application.
US08764477B2 Plug wire type lampholder
A plug-wire type lampholder comprises an acting body having a set of slots formed in the acting body and provided for installing a wire clamping plate separately, and the wire clamping plate has at least one end bent to form two into movable plates, and each slot has two notches and different notches are separated with an interval apart, so that when the wire clamping plate is installed into the slot, the movable plates remain in different corresponding notches respectively, and in different notches the same slot are provided for plugging bare ends of different electric wires respectively to achieve an electric conduction, so as to facilitate connecting lamps of different plug-wire type lampholders into a lamp string quickly.
US08764470B2 Board to board connector with enhanced metal locking features
An electrical connector includes an insulative housing defining a mating slot, a number of contacts and a pair of metal hold downs fastened in the insulative housing. Each contact includes a contacting portion extending into the mating slot. Each metal hold down includes a first portion, a second portion perpendicular to the first portion and a connecting portion connecting the first portion and the second portion. The first portion defines a first hole, the second portion defines a second hole for maintaining solders, and the connecting portion defines a third hole connecting the first hole and the second hole. The first portion and the connecting portion are insert molded in the insulative housing with material of the insulative housing filling in the first and the third holes.
US08764467B2 External connector for solid insulated load break switchgear
Disclosed is an external connector for a solid insulated load break switchgear. A semi-conductive layer for uniformly distributing an inner field is formed in a body part of a connector to uniformly distribute an inner field. This may prevent partial lowering of an insulating performance of the connector to enhance the insulating performance of the connector. Furthermore, a semi-conductive layer for uniformly distributing an outer field is formed between the connector and a bushing coupled to an upper end of the connector, and between the connector and a plug coupled to a lower end of the connector. This may allow an electric field to be uniformly distributed to a part connected to a ground surface of an arc extinguishing part.
US08764465B2 Connector mechanism having a pivotably disposed cover and a resilient component engaging the cover
A connector mechanism includes a base, a cover and a resilient component. An opening is formed on the base, and an external plug can inset into the opening. The cover is pivotably disposed on the base. The cover includes a first portion, a second portion and an axle. The first portion rotates to a first position for covering the opening, and further rotates to a second position to hold a body of the external plug. The second portion includes a buckling structure for buckling a pin of the external plug when the first portion rotates to the second position, so as to constrain a movement of the external plug relative to the base. Two ends of the resilient component respectively contact against the base and the cover, and the cover can cover the opening via a resilient recovering force of the resilient component.
US08764461B2 System for electrically connecting conductor to track member
A system for electrically connecting a conductor to a track member includes a clamp base, a clamp bolt, and a wire bolt. The clamp base receives part of the track member, and has a threaded throughbore. The clamp bolt includes a spike pin and a body that is threaded for screwing into the clamp base. The body defines a threaded recess. The wire bolt has a longitudinal throughbore, and is threaded for screwing into the recess. When the conductor is positioned through the wire bolt and the wire bolt is screwed into the recess, the wire bolt holds the conductor in place in electrical engagement with the clamp bolt. When the track member part is received in the clamp base and the clamp bolt is screwed through the clamp base, the spike pin bites into the track member for establishing an electrical connection and clamping the clamp base in place.
US08764456B2 Simulated structures for urban operations training and methods and systems for creating same
Methods, systems, and structures are provided to creating a simulated structure for urban operations training based on a structure to be simulated. The simulated structure can include a base structure having at least one wall thereon. The simulated structure can also include one or more wall segments having a textured surface to securement to the at least one wall of the base structure. One or more wrapping material panels with one or more images printed thereon applied to the textured surface of the one or more wall segments so that the simulated structure has realistic visual characteristics representative of a mission site or a mission scenario.
US08764454B1 Individualized academic focus credential structure, system and methods thereof
The present disclosure relates to a computer-optimized academic credential structure, model and processes, with academic integrity, and associated marketing, for existing or new programs at regionally and nationally accredited and other postsecondary, higher education institutions. In one illustrative embodiment, an academic structure is provided to allow student's individually generated content from parts of multiple courses to be aggregated into a new academic credential, the focus credential. In another illustrative embodiment, a developed and highly innovative computer-enabled Internet-optimized academic credential model and processes, with academic integrity, for existing or new programs at regionally and nationally accredited and other postsecondary, higher education institutions is provided. This model allows a postsecondary student to earn an individualized credential within existing academic program formats.
US08764446B2 M249 non-firearm simulating a functional M249 firearm
A non-firing housing imitates a functioning receiver for an M249 machine gun. The non-firing housing includes one or more of a number of alterations as compared to a functioning M249 receiver. Such alterations include: providing a non-firing barrel support with substantial dimensional differences as compared to a standard M249 barrel support; providing a non-firing barrel support with additional structural features that prevent any bolt head (and particularly a standard M249 bolt head) from entering the battery position; providing right or left non-firing bolt rails with dimensional or structural or positional alterations as compared to standard right and left bolt rails for a standard M249; providing the non-firing housing with the absence of an ejection port; providing a non-firing right bolt rail with the absence of a hinge bore; and providing a non-firing left bolt rail with the absence of an ejector pin bore and back stop material.
US08764445B1 Dental appliance
An exemplary dental appliance for application to a jaw of a dental patient includes a teeth section having at least one tooth receptacle, at least one removable retention component carried by the teeth section and at least one fixed retention component adapted for attachment to the jaw of the dental patient and engaged by the at least one removable retention component.
US08764441B2 Method and internal apparatus for determining final position of dentate skeleton in orthognathic surgery
A skeletal positioning method and apparatus includes a splint having a main body coupled to a skeletal structure of a patient and a positioning guide having a skeletal footplate, a splint footplate, and an arm coupling the skeletal footplate and the splint footplate, the skeletal footplate including at least one aperture formed therein and the splint footplate including connectors for releasably coupling the positioning guide to the splint, wherein a relative position and orientation of the skeletal footplate and the splint footplate is pre-determined to align a portion of the skeletal footplate with a pre-defined portion of the skeletal structure of the patient.
US08764437B2 Burner and cooker including the burner
A burner and a cooker including the burner are provided. The burner includes a burner port, an ignition unit configured to ignite a mixture gas in the burner port, a combustion member located between the burner port and the ignition unit, a plurality of combustion compartments defined by portions of the burner port and the combustion member to allow combustion of the mixture gas in the combustion compartments, and an ignition compartment defined by the remaining portions of the burner port and the combustion member to allow ignition of the mixture gas supplied from the combustion compartments, whereby a flame generated by igniting the mixture gas in the ignition compartment is propagated to the combustion compartments. The cooker includes a cooking cavity, the burner, mixing tubes for the mixture of gas, and a door closing the cooking cavity.
US08764436B2 Valve assemblies for heating devices
In certain embodiments, a valve assembly can comprise a housing, a valve body, a first burner nozzle member and a second burner nozzle member. The housing can define an oxygen depletion sensor (ODS) inlet and a burner inlet. The valve body can be positioned within the housing and configured to rotate between a first position for a first fuel type and a second position for a second fuel type different from the first.
US08764431B2 Method and apparatus for transcripting fine patterns
In a method for transcripting fine patterns and an apparatus for transcripting fine patterns, the ingress of bubbles is prevented and patterns are transcripted with a high throughput by a relatively compact apparatus. For this purpose, a back surface of a stamper is vacuum sucked and the stamper is brought into close contact with a target of transcription with its surfaces coated with resist and pressure is applied thereto. At this time, the stamper is deformed into a spherical shape or bent to expand the close contact face from a central area to a peripheral area to prevent the ingress of air bubbles into between the target of transcription and the stamper.
US08764427B2 Apparatus for forming pattern using laser
An apparatus for forming a pattern using a laser is provided. The apparatus includes a pattern storing unit, a controller, a laser oscillating unit, an X-Y driver, a header unit, and a stage. The pattern storing unit stores data on light guide patterns of a discontinuous straight line shape. The controller transmits position signal of the light guide patterns to the X-Y driver and simultaneously, transmits a switching signal to the laser oscillating unit. The laser oscillating unit outputs a laser beam synchronized with a movement of the header unit. The X-Y driver moves the header unit and the stage. The header unit moves along a first guide rail. The stage moves along a fixed second guide rail in the front and rear direction of the light guide panel.
US08764426B2 Electromotive injection molding machine and power supplying method of electromotive injection molding machine
A power supplying apparatus for supplying power to servo amplifiers is configured by an AC/DC converter and a predetermined power storage circuit. In a process of a molding cycle except for an injection process, power is supplied from the AC/DC converter, and the power is stored in the power storage circuit. In the injection process, the AC/DC converter and the power storage circuit are controlled in conjunction with each other to supply the stored power, which is required when performing the injection process, from the power storage circuit, so as to prevent the AC/DC converter from supplying an excessive amount of power.
US08764424B2 Screw pump with field refurbishment provisions
A screw pump (20) with field refurbishment provisions has screws (40), a base (26), and shafts (50) for the screws (40). The screws (40) have helical flights that intermesh during rotation, and extend between inner and outer ends (44 and 42). The shafts (50) extend between inner and outer ends (68 and 74), and are cantilevered from the base (26) from about the inner end (68) thereof. Each screw (40) is formed with a hollow core (80) for receiving its shaft (50) such that the screw (40) slips onto the respective shaft (50) therefor over the outer end (74) of its shaft (50). The screw pump further includes a keyless locking mechanism (56, 58, 96, or 98) intermediate each shaft (50) and screw (40), which is operative to rotationally lock the shaft (50) and screw (40) together without a key or keyway.
US08764420B2 Eccentric-screw pump with replaceable rotor and stator
An eccentric-screw pump has an axially split stator having axially opposite intake and output ends and an elastomeric liner defining an axially throughgoing passage. Respective intake and output housings are releasably secured to the intake and output ends of the stator. An axially extending screw rotor in the passage has an end in the intake housing. A drive includes a rotatable universal joint having a pair of relatively swivelable parts in the intake housing. Respective generally complementary formations on the end of the rotor and on one of the universal-joint parts can fit axially together to rotationally couple the one universal-joint part with the rotor. A latch secures the formations axially together for angular force transmission between the one universal-joint part and the rotor.
US08764418B2 Centrifugal fan
An impeller comprises an impeller body, a plurality of stems, a blade mounting member, and a plurality of blades. The stems radially extend with one end of each stem fixed to a portion of a circumferential wall of the impeller body in the vicinity of a suction port, and are arranged at intervals in a circumferential direction of the circumferential wall. The stems assist the impeller to suck air Jn an axial direction through a suction port during rotation of the impeller. The blade mounting member is disposed concentrically with the circumferential wall of the impeller body. The other end of each stem is fixed to the blade mounting member. The blades are arranged at intervals in the circumferential direction and extend along an axial line toward a second wall portion, with one end of each blade fixed to the blade mounting member.
US08764416B2 Closed type compressor
A closed type compressor of a low overall height and small vibrations provided with a structure comprising a balancing weight (142) formed of a first balancing weight (146) and a second balancing weight (148) and fixed to eccentric shaft portion (112), the first balancing weight (146) located closer to a main shaft portion (109) than the second balancing weight (148), and the second balancing weight (148) jutting out to a position further from an axis of the eccentric shaft portion (112) than the first balancing weight (146).
US08764413B2 Pumping arrangement
A differentially pumped vacuum system includes first, second and third chambers, and a pumping arrangement for evacuating the chambers. The pumping arrangement includes a compound pump having a first inlet connected to an outlet from the first chamber, a second inlet connected to an outlet from the second chamber, a first pumping section and a second pumping section downstream from the first pumping section, the sections being arranged such that fluid entering the compound pump from the first inlet passes through the first and second pumping sections and fluid entering the compound pump from the second inlet passes through, of said sections, only the second section. The pumping arrangement further includes a booster pump connected to an outlet from the third chamber, and a backing pump connected to the exhaust from the booster pump. Fluid exhaust from the compound pump can be conveyed to either the booster pump or the backing pump as required.
US08764410B2 Capacitive device and method for the electrostatic transport of dielectric and ferroelectric fluids
In a method for conveying at least one heat exchange medium which includes at least one first fluid having a first permittivity and at least one second fluid which does not mix with the first fluid and has a second permittivity that differs from the first permittivity, at least one dielectric boundary surface is formed between the first and the second fluid, which boundary surface is exposed to a progressively excited electric displacement field which exerts a displacement force on the at least one dielectric boundary surface.
US08764409B2 Apparatus and method for controlling operation of compressor
An apparatus and method for controlling an operation of a compressor are disclosed to enhance a compressor efficiency in each operation mode in operating a compressor in a power mode or power saving mode according to an external load. The apparatus for controlling an operation of a compressor, including: a controller that generates a control signal to select an operation mode of the compressor according to an operation load of the compressor; a compressor motor that includes a main coil and a sub-coil and is driven in one of a plurality of operation modes according to a control signal of the controller; and a power supply unit that applies power via capacitors each having a different capacitance to the sub-coil of the compressor motor according to a control signal of the controller.
US08764405B2 Dynamic compensation of airflow in electronics enclosures with failed fans
An approach is provided in which a cooling manager detects a failed fan included in an electronic enclosure. The electronic enclosure includes multiple fans that each cool different component areas in the electronic enclosure. The cooling manager selects an airflow compensator that corresponds to a functioning fan included in the electronic enclosure, which includes a fixed perforated member and a movable perforated member. In turn, the cooling manager adjusts the selected airflow compensator to redirect a portion of airflow generated by the functioning fan to the component area corresponding to the failed fan.
US08764400B2 Blower for a particulate loader and transfer apparatus
A blower for a particulate loader and transfer apparatus is provided. The blower comprises at least one blade having a proximal and a distal end. A drive mechanism rotates the at least one blade in a direction about an axis of rotation. The proximal end of the blade is nearer to the axis of rotation than the distal end of the blade is to the axis of rotation and the blade is angled so that as the blade rotates about the axis, the proximal end of the blade precedes the distal end of the blade.
US08764399B1 Spiral plane drag turbine
The present invention provides systems, devices, and methods for transferring kinetic energy from a working fluid to mechanical energy. The claimed device comprises a housing, at least one fluid inlet, a rotor assembly with a plurality of closely related blades that are positioned to create at least one spiral pathway which is continuous for the length of the rotor assembly, a shaft connected to the rotor assembly, and at least one fluid outlet. The energy is transferred when a working fluid enters the fluid inlet, flows trough the spiral pathway in the rotor assembly's direction of rotation, and exits through the fluid outlet.
US08764396B2 Lead-lag damper for rotor hubs
A lead-lag damper for a rotor assembly has a body mounted to either an inboard portion of a blade assembly or a fixed portion of the rotor assembly. A piston carried within the body is configured to allow for relative motion between the body and the piston. The piston defines opposing chambers within the body, the chambers being in fluid communication through a fluid passage. A link connects the piston to the other of the inboard portion of the blade assembly and the fixed portion of the rotor assembly, and the link engages a central portion of the piston. The piston acts on fluid in the chambers during relative motion between the piston and the body and causes fluid flow between the chambers through the fluid passage. Flow through the passage acts to damp lead-lag motion of the blade assembly relative to the fixed portion of the rotor assembly.
US08764394B2 Component cooling channel
A cooling channel (36, 36B) cools an exterior surface (40 or 42) or two opposed exterior surfaces (40 and 42). The channel has a near-wall inner surface (48, 50) with a width (W1). Interior side surfaces (52, 54) may converge to a reduced channel width (W2). The near-wall inner surface (48, 50) may have fins (44) aligned with a coolant flow (22). The fins may highest at mid-width of the near-wall inner surface. A two-sided cooling channel (36) may have two near-wall inner surfaces (48, 50) parallel to two respective exterior surfaces (40, 42), and may have an hourglass shaped transverse sectional profile. The tapered channel width (W1, W2) and the fin height profile (56A, 56B) increases cooling flow (22) into the corners (C) of the channel for more uniform and efficient cooling.
US08764388B2 Variable geometry turbine
A variable geometry turbine comprises: a turbine wheel (5) in a housing (1) for rotation about a turbine axis, an annular inlet passage (9) defined between respective radial inlet surfaces of first and second wall members (11, 12), at least one of said first and second wall members being moveable along the turbine axis to vary the size of the inlet passage; an array of vanes (14) extending across the inlet passage, said vanes being connected to said first wall member; a complementary array of vane slots (28) defined by the second wall member, said vane slots configured to receive said vanes to accommodate relative movement between the first and second wall members; the second wall member comprising at least two axially adjacent co-axial plates (29, 30), a first plate (29) defining a first array of openings which overlie a second array of openings defined by a second plate (30) so as to define said array of vane slots, said first plate being fixed to said second plate.
US08764384B2 Joint for housing alignment
An assembly kit includes a first turbocharger component flange with receptacles spaced according to a first interval angle; a second turbocharger component flange with receptacles spaced according to a second interval angle that differs from the first interval angle; and a piece configured for receipt by a receptacle of the first component and a receptacle of the second component where alignment of the receptacles determines a rotational orientation angle of the first component with respect to the second component. Various other examples of devices, assemblies, systems, methods, etc., are also disclosed.
US08764380B2 Rotor blade
A rotor blade for a gas turbine engine, comprising an aerofoil having pressure and suction surfaces, leading and trailing edges, and an array of passages at a tip region of the aerofoil. The passages extend from the pressure surface to the suction surface of the aerofoil and are disposed so that the array creates, in operation, a planar jet of gas issuing from the suction surface. The jet is inclined outwardly from the suction surface and towards the tip, and in the direction from the leading edge to the trailing edge. The jet inhibits migration away from the suction surface of a clearance vortex formed by leakage of air over the tip of the rotor blade.
US08764378B2 Centrifugal pump assembly
A centrifugal pump assembly with at least one impeller (8) and with a thrust bearing (44) which includes a rotating (50) and a stationary (48) bearing part. The rotating (50) as well as the stationary (48) bearing part are designed in a self-aligning manner.
US08764374B2 Separating tool for feeding receptacle
A separating tool for separating out objects one by one from a stack of objects includes a support base, an assembly plate positioned on the support base, a vertical sliding assembly slidably positioned on the assembly plate, and two opposing clamping members connected to the vertical sliding assembly. Each clamping member includes an engaging plate, a connecting shaft fixed to the engaging plate, and a cam base positioned on the support base. The cam base defines a cam slot, and the connecting shaft slides in the cam slot. A distance from a top end of the cam slot to the engaging plate is less than that from a bottom end of the cam slot to the engaging plate, such that the engaging plates of the two clamping members move together when the engaging plates are moved upwards with the connecting shaft.
US08764373B2 Utility carryall for utility, skid steer and industrial tractors
The UTILITY CARRYALL provides a safe reliable and efficient lift and transport support for users in the agricultural industries. It can be coupled to all hydraulic front loaders and rear 3point hitches on utility, skid steer and industrial tractors. It also can be attached to a forklift on a rear hydraulic 3point hitch and front loader on utility farm and skid steer tractors. The front support rack 22 supports a multiple adjusting coupling system FIGS. 1,6. This system provides a capability for coupling the utility carryall to all varying widths of front loader lift arms on utility tractors. A uniquely designed profile providing a method for a new unified structural support system in combination with a new multiple adjusting coupling system, illustrated in FIGS. 1, 6. This new method of fabrication provides an interrelated multifunctional exchange between integral elements of both systems. System unification provided a new fabrication process for reducing overall unit weight while increasing structural support providing dispersal of load stress throughout the whole unit. These features introduce a new dimension with major improvements in lift and transport support for the high tech hydraulic systems for utility tractors being used today. The Utility Carryall can be matched to provide safe and reliable support for small compact, medium and large size utility tractors with wide and varying ranges of hydraulic lift capacities.
US08764368B2 Apparatus and method for handling tubulars
An apparatus for use in delivering tubulars to an elevated work area is described. A slideway for receiving a tubular is mounted on the leading end of an extendable carriage. The opposing end of the carriage is pivotally fixed to a frame assembly. Extension of the carriage drives the leading end towards a work area. A carriage support ramp receives the leading end of the carriage as it is extended, and guides the leading end towards the elevated work area for discharge of the tubular from the slideway.
US08764362B2 Push-on bolt stabilizer
The invention provides for a retainer for stabilizing a threaded member. The retainer may include a base portion having an opening and an outer perimeter lying in a first plane, the opening having a plurality of elongated sections each extending toward the outer perimeter so as to define in the base portion one or more arms. Each of the aims may have a head section having at least one groove, the head sections being located in a second plane which is parallel to and spaced apart from the first plane. The elongated sections may be symmetrically arranged about an axis. The grooves may be arranged to define at least a portion of a helix. The outer perimeter of the retainer may be circular.
US08764360B2 Strap connector
Described are connectors comprising: a body; at least four arms extending from the body; a first pair of opposing, substantially closed slots along a first axis of the body, wherein each slot is defined by one or more of the at least four arms and an edge of the body; and a second pair of opposing, substantially closed slots along a second axis of the body, wherein each slot is defined by one or more of the at least four arms and an edge of the body; wherein, each slot comprises an opening defined by at least two of the at least four arms; and wherein, the openings of the first pair of opposing, substantially closed slots are offset and the openings of the second pair of opposing, substantially closed slots are offset. Methods of coupling straps together via such connectors, and the resulting net-like structure, are also described.
US08764359B2 Built-in movable pallet for container
The present invention relates to a kind of built-in movable pallet for containers, including the rectangular chassis with several rollers at the bottom. Several guiding mechanisms are set at both sides and the corners of front edge of the above-mentioned chassis; guiding mechanisms are guide roller structures; outer peripheral surface of guiding rollers protrudes to side edge of the chassis; locking mechanisms are installed at the two corners at rear edge of the chassis. In this invention, guide rollers are installed at two sides and the corners of front edge, so that the sliding friction with high resistance is converted into rolling friction with low resistance. While loading, outer peripheral surface of the guide rollers at corners of front edge contacts the firm doorframe of the container firstly, so relative parallel position of the pallet and the container is adjusted properly and basically; while further pushing, the relative position between the pallet and the container may be adjusted adaptively by guide rollers at sides, so as to prevent wall of the container from being crashed and even cut and protect the container effectively; the locking hook at corners of rear edge is reasonable structure, convenient for use and can be locked reliably.
US08764358B2 Rack for load bars
A rack for storing load bars against the side wall of the cargo area of a cargo truck equipped with E-track. The rack includes a generally U-shaped base having a rear side equipped with E-clips for mounting on the side wall, a closed end, a front side having two vertically-spaced horizontal cantilevered retainer arms substantially parallel to the side wall when the rack is mounted, and an open end. Load bars are inserted and removed from the rack in a plane parallel to the side wall the cargo area, in a vertical orientation, and are secured in place with a horizontal adjustable-length strap operable in the space between the front retainer arms to selectively close off the open end of the rack.
US08764354B2 Cutting tool for a machine tool
The invention relates to a cutting tool for a machine tool, comprising a cutting head (1), a shaft (2), and a coupling which removably fixes the cutting head (1) to the shaft (2), said coupling comprising a coupling pin (6) on the back of the cutting head (7) and a receptacle (5) in the shaft (2), which receptacle is complementary to the coupling pin (6) and accommodates the coupling pin (6) when the coupling is closed, comprising a central coolant channel (20) in the shaft (2), which separates into two sub-channels (12) in the region of the receptacle (5), the two sub-channels (12) flanking the receptacle (5) in the wall thereof and opening into the flat contact surface (10) annularly surrounding the opening edge (8) of the receptacle (5), and comprising a flat collar (16) on the back of the cutting head (7) having an annular distribution groove (15). The tool also comprises at least one coolant hole (19) connecting the cutting edges (14) on the cutting head (1) to the distribution groove (15).