| Document | Document Title |
|---|---|
| US08716864B2 |
Solderless die attach to a direct bonded aluminum substrate
A DBA-based power device includes a DBA (Direct Bonded Aluminum) substrate. An amount of silver nanoparticle paste of a desired shape and size is deposited (for example by micro-jet deposition) onto a metal plate of the DBA. The paste is then sintered, thereby forming a sintered silver feature that is in electrical contact with an aluminum plate of the DBA. The DBA is bonded (for example, is ultrasonically welded) to a lead of a leadframe. Silver is deposited onto the wafer back side and the wafer is singulated into dice. In a solderless silver-to-silver die attach process, the silvered back side of a die is pressed down onto the sintered silver feature on the top side of the DBA. At an appropriate temperature and pressure, the silver of the die fuses to the sintered silver of the DBA. After wirebonding, encapsulation and lead trimming, the DBA-based power device is completed. |
| US08716863B2 |
Structure and method for high performance interconnect
The present disclosure provides an integrated circuit structure. The integrated circuit structure includes a substrate having an IC device formed therein; a first dielectric material layer disposed on the substrate and having a first trench formed therein; and a first composite interconnect feature disposed in the first trench and electrically coupled with the IC device. The first composite interconnect feature includes a first barrier layer disposed on sidewalls of the first trench; a first metal layer disposed on the first barrier layer; and a first graphene layer disposed on the metal layer. |
| US08716862B2 |
Integrated circuit including a gate and a metallic connecting line
An integrated circuit includes a gate of a transistor disposed over a substrate. A connecting line is disposed over the substrate. The connecting line is coupled with an active area of the transistor. A level difference between a top surface of the connecting line and a top surface of the gate is about 400 Å or less. A via structure is coupled with the gate and the connecting line. A metallic line structure is coupled with the via structure. |
| US08716858B2 |
Bump structure with barrier layer on post-passivation interconnect
A semiconductor device includes a barrier layer between a solder bump and a post-passivation interconnect (PPI) layer. The barrier layer is formed of at least one of an electroless nickel (Ni) layer, an electroless palladium (Pd) layer or an immersion gold (Au) layer. |
| US08716855B2 |
Integrated circuit system with distributed power supply comprising interposer and voltage regulator module
An integrated circuit system having an interposer and an integrated circuit with first and second bond pads, the integrated circuit die bonded to the interposer using the first bond pads. The integrated circuit having circuit blocks, that operate at different operating voltages and voltage regulator modules die bonded to the second bond pads of the integrated circuit. The voltage regulator modules converting a power supply voltage to the operating voltage of a respective circuit block and supply the respective operating voltage to the circuit block via the second bond pads. |
| US08716854B2 |
Multi-chip package
A multi-chip package includes a main substrate; a plurality of first semiconductor chips stacked on an upper surface of the main substrate and having bonding pads which are electrically connected with the main substrate; and a semiconductor package attached to side surfaces of the stacked first semiconductor chips and electrically connected with the main substrate. |
| US08716849B2 |
Semiconductor device including one or more stiffening elements
A stiffener molded to a semiconductor substrate, such as a lead frame, and methods of molding the stiffener to the substrate are provided. The stiffener is molded to the substrate to provide rigidity and support to the substrate. A stiffener material can comprise a polymeric material molded to the substrate by a molding technique such as transfer molding, injection molding, and spray molding, or using an encapsulating material. One or more dies, chips, or other semiconductor or microelectronic devices can be disposed on the substrate to form a die assembly. The stiffener can be molded to a substrate comprising one or more dies, over which an encapsulating material can be applied to produce a semiconductor die package. |
| US08716848B2 |
LED device with conductive wings and tabs
Apparatus for increased heat dissipation from a light-emitting diode (LED) die are provided. The apparatus may include a metal member thermally and electrically coupled to the LED die and having one or more wings for heat transfer away from the LED die and/or increased mechanical strength of the metal member. The wings may be flat, sloped, or tiered. For some embodiments, the wings may have holes in them in an effort to increase the structural integrity when combined with a housing, which made be composed of plastic or resin. |
| US08716835B2 |
Bipolar transistor
A bipolar transistor is provided with an emitter layer, a base layer and a collector layer. The emitter layer is formed above a substrate and is an n-type conductive layer including a first nitride semiconductor. The base layer is formed on the emitter layer and is a p-type conductive including a second nitride semiconductor. The collector layer is formed on the base layer and includes a third nitride semiconductor. The collector layer, the base layer and the emitter layer are formed such that a crystal growth direction to the substrate surface is parallel to a substrate direction of [000-1]. The third nitride semiconductor contains InycAlxcGa1-xc-ycN (0•xc•1, 0•yc•1, 0 |
| US08716833B2 |
Semiconductor devices and methods of manufacturing the same
A method of manufacturing a semiconductor device including forming on a substrate an insulating interlayer through which a capacitor contact is interposed; forming on the insulating interlayer a first upper electrode having an opening through which the capacitor contact is exposed; forming a first dielectric layer pattern on a lateral wall of the opening; forming a lower electrode on the first dielectric layer pattern formed in the opening and the capacitor contact; forming a second dielectric layer pattern on the lower electrode formed in the opening and the first dielectric layer pattern; and forming on the second dielectric layer pattern a second upper electrode so as to fill the opening and to contact the first upper electrode. The semiconductor device may prevent a lower electrode of a capacitor from collapsing. |
| US08716829B2 |
Semiconductor devices with sealed, unlined trenches and methods of forming same
A semiconductor device includes unlined and sealed trenches and methods for forming the unlined and sealed trenches. More particularly, a superjunction semiconductor device includes unlined, and sealed trenches. The trench has sidewalls formed of the semiconductor material. The trench is sealed with a sealing material such that the trench is air-tight. First and second regions are separated by the trench. The first region may include a superjunction Schottky diode or MOSFET. In an alternative embodiment, a plurality of regions are separated by a plurality of unlined and sealed trenches. |
| US08716827B2 |
Diffusion resistor with reduced voltage coefficient of resistance and increased breakdown voltage using CMOS wells
Integrated circuits and manufacturing methods are presented for creating diffusion resistors (101, 103) in which the diffusion resistor well is spaced from oppositely doped wells to mitigate diffusion resistor well depletion under high biasing so as to provide reduced voltage coefficient of resistivity and increased breakdown voltage for high-voltage applications. |
| US08716825B2 |
Semiconductor structure and manufacturing method for the same
A semiconductor structure and a manufacturing method for the same are provided. The semiconductor structure includes a well region, a dielectric structure, a first doped layer, a second doped layer and a first doped region. The dielectric structure is on the well region. The dielectric structure has a first dielectric sidewall and a second dielectric sidewall opposite to each other. The dielectric structure includes a first dielectric portion and a second dielectric portion, between the first dielectric sidewall and the second dielectric sidewall. The first doped layer is on the well region between the first dielectric portion and the second dielectric portion. The second doped layer is on the first doped layer. The first doped region is in the well region on the first dielectric sidewall. |
| US08716822B2 |
Back-illuminated type solid-state imaging device and method of manufacturing the same
A solid-state imaging device according to an embodiment includes: a plurality of pixels arranged on a first face of a first semiconductor layer, each of the pixels including a photoelectric conversion element converting light entering through a second face of the first semiconductor layer on the opposite side from the first face into a signal charge, the photoelectric conversion element having a pn junction formed with a first semiconductor region formed on the first face and a second semiconductor region formed on a surface of the first semiconductor region; pixel separating regions separating the pixels from one another and formed between the pixels, each of the pixel separating regions including a second semiconductor layer covering faces in contact with the photoelectric conversion elements, and an insulating film with a lower refractive index than a refractive index of the second semiconductor layer to cover the second semiconductor layer. |
| US08716820B2 |
Magnetic memory
A memory includes an underlying layer of a ferromagnetic body, a first nonmagnetic layer on the underlying layer, a data memorizing layer laid on the first nonmagnetic layer and made of a ferromagnetic body having perpendicular magnetic anisotropy, a reference layer coupled through a second nonmagnetic layer with the data memorizing layer, and first and second magnetization fixed layers laid underneath the underlying layer to come into contact with the underlying layer. The data memorizing layer includes a magnetization liberalized region having reversible magnetization, and overlapping with the reference layer, a first magnetization fixed region coupled with an end of the magnetization liberalized region, and having a magnetization direction fixed to +z direction by the first magnetization fixed layer, and a second magnetization fixed region coupled with a different end of the magnetization liberalized region, and having a magnetization direction fixed to −z direction by the second magnetization fixed layer. |
| US08716818B2 |
Magnetoresistive element and method of manufacturing the same
According to one embodiment, a magnetoresistive element includes a storage layer having a variable and perpendicular magnetization, a tunnel barrier layer on the storage layer, a reference layer having an invariable and perpendicular magnetization on the tunnel barrier layer, a hard mask layer on the reference layer, and a sidewall spacer layer on sidewalls of the reference layer and the hard mask layer. An in-plane size of the reference layer is smaller than an in-plane size of the storage layer. A difference between the in-plane sizes of the storage layer and the reference layer is 2 nm or less. The sidewall spacer layer includes a material selected from a group of a diamond, DLC, BN, SiC, B4C, Al2O3 and AlN. |
| US08716817B2 |
Magnetic memory element and nonvolatile memory device
According to one embodiment, a magnetic memory element includes a stacked body including first and second stacked units stacked with each other. The first stacked unit includes first and second ferromagnetic layers and a first nonmagnetic layer provided therebetween. The second stacked unit includes third and fourth ferromagnetic layers and a second nonmagnetic layer provided therebetween. Magnetization of the second and third ferromagnetic layers are variable. Magnetizations of the first and fourth ferromagnetic layers are fixed in a direction perpendicular to the layer surfaces. A cross-sectional area of the third ferromagnetic layer is smaller than a cross-sectional area of the first stacked unit when cut along a plane perpendicular to the stacking direction. |
| US08716815B2 |
MEMS coupler and method to form the same
A MEMS coupler and a method to form a MEMS structure having such a coupler are described. In an embodiment, a MEMS structure comprises a member and a substrate. A coupler extends through a portion of the member and connects the member with the substrate. The member is comprised of a first material and the coupler is comprised of a second material. In one embodiment, the first and second materials are substantially the same. In one embodiment, the second material is conductive and is different than the first material. In another embodiment, a method for fabricating a MEMS structure comprises first forming a member above a substrate. A coupler comprised of a conductive material is then formed to connect the member with the substrate. |
| US08716810B2 |
Selective floating body SRAM cell
A memory cell has N≧6 transistors, in which two are access transistors, at least one pair [say (N−2)/2] are pull-up transistors, and at least another pair [say (N−2)/2] are pull-down transistors. The pull-up and pull-down transistors are all coupled between the two access transistors. Each of the access transistors and the pull-up transistors are the same type, p-type or n-type. Each of the pull-down transistors is the other type, p-type or n-type. The access transistors are floating body devices. The pull-down transistors are non-floating body devices. The pull-up transistors may be floating or non-floating body devices. Various specific implementations and methods of making the memory cell are also detailed. |
| US08716808B2 |
Static random-access memory cell array with deep well regions
An integrated circuit including a complementary metal-oxide-semiconductor (CMOS) static random access memory (SRAM) with periodic deep well structures within the memory cell array. The deep well structures are contacted by surface well regions of the same conductivity type (e.g., n-type) in the memory cell array, forming two-dimensional grids of both n-type and p-type semiconductor material in the memory cell array area. Bias conductors may contact the grids to apply the desired well bias voltages, for example in well-tie regions or peripheral circuitry adjacent to the memory cell array. |
| US08716804B2 |
Device and methods for small trench patterning
A semiconductor device and methods for small trench patterning are disclosed. The device includes a plurality of gate structures and sidewall spacers, and an etch buffer layer disposed over the sidewall spacers. The etch buffer layer includes an overhang component disposed on the upper portion of the sidewall spacers with an edge that extends laterally. The width between the edges of adjacent overhang components is narrower than the width between adjacent sidewall spacers. |
| US08716802B2 |
Semiconductor device structure and fabricating method thereof
A semiconductor device structure including a substrate, a resistor, and a first gate structure is provided. The substrate includes a resistor region and a metal-oxide-semiconductor (MOS) transistor region. The resistor is disposed on the substrate within the resistor region. The resistor includes a first dielectric layer, a metal layer, a second dielectric layer, and a semiconductor layer sequentially stacked on the substrate. The first gate structure is disposed on the substrate within the MOS transistor region. The first gate structure includes the first dielectric layer, the metal layer, and the semiconductor layer sequentially stacked on the substrate. |
| US08716800B2 |
Semiconductor structure and method for manufacturing the same
Semiconductor structure and methods for manufacturing the same are disclosed. In one embodiment, the semiconductor device is formed on an SOI substrate comprising an SOI layer, a buried insulating layer, a buried semiconductor layer and a semiconductor substrate from top to bottom, and comprises: source/drain regions formed in the SOI layer; a gate formed on the SOI layer, wherein the source/drain regions are located at both sides of the gate; a back gate region formed by a portion of the buried semiconductor layer which is subjected to resistance reduction; and a first isolation structure and a second isolation structure which are located at both sides of the source/drain regions and extend into the SOI substrate; wherein the first isolation structure and the second isolation structure laterally adjoin the SOI layer at a first side surface and a second side surface respectively; the first isolation structure laterally adjoins the buried semiconductor layer at a third side surface; and the third side surface is located between the first side surface and the second side surface. |
| US08716799B2 |
MOSFET
The present application discloses a MOSFET and a method for manufacturing the same, wherein the MOSFET comprises: an SOI wafer, which comprises a semiconductor substrate, a buried insulator layer, and a semiconductor layer, the buried insulator layer being disposed on the semiconductor substrate, and the semiconductor layer being disposed on the buried insulator layer; a gate stack, which is disposed on the semiconductor layer; a source region and a drain region, which are disposed in the semiconductor layer and on opposite sides of the gate stack; and a channel region, which are disposed in the semiconductor layer and sandwiched by the source region and the drain region, wherein the MOSFET further comprises a back gate disposed in the semiconductor substrate, and wherein the back gate comprises first, second and third compensation doping regions, the first compensation doping region is disposed under the source region and the drain region; the second compensation doping region extends in a direction away from the channel region and adjoining the first compensation doping region; and the third compensation doping region is disposed under the channel region and adjoining the first compensation doping region. By changing the doping type of the back gate, the MOSFET can have an adjustable threshold voltage, and can have a reduced parasitic capacitance and a reduced contact resistance in connection with the back gate. |
| US08716798B2 |
Methodology for fabricating isotropically recessed source and drain regions of CMOS transistors
A method for fabricating recessed source and recessed drain regions of aggressively scaled CMOS devices. In this method a processing sequence of plasma etch, deposition, followed by plasma etch is used to controllably form recessed regions of the source and the drain in the channel of a thin body, much less than 40 nm, device to enable subsequent epitaxial growth of SiGe, SiC, or other materials, and a consequent increase in the device and ring oscillator performance. A Field Effect Transistor device is also provided, which includes: a buried oxide layer; a silicon layer above the buried oxide layer; an isotropically recessed source region; an isotropically recessed drain region; and a gate stack which includes a gate dielectric, a conductive material, and a spacer. |
| US08716794B2 |
SOI lateral MOSFET devices
The present invention relates to a semiconductor power device and power integrated circuits (ICs). The lateral SOI MOSFET in the present comprises a trench gate extended to the dielectric buried layer, one or multiple dielectric trenches in the drift region, and a buried gate in said dielectric trench. The permittivity of the dielectric in said dielectric trench is lower than that of said active layer. Firstly, said dielectric trench not only greatly improves breakdown voltage, but also reduces pitch size. Secondly, the trench gate widens the effective conductive region in the vertical direction. Thirdly, dual gates of said trench gate and buried gate increase channel and current densities. Thereby, specific on-resistance and the power loss are reduced. The device of the present invention has many advantages, such as high voltage, high speed, low power loss, low cost and ease of integration. The device in the present invention is particularly suitable for power integrated circuits and RF power integrated circuits. |
| US08716788B2 |
Semiconductor device with self-charging field electrodes
Disclosed is a semiconductor device including a drift region of a first doping type, a junction between the drift region and a device region, and at least one field electrode structure in the drift region. The field electrode structure includes a field electrode, a field electrode dielectric adjoining the field electrode and arranged between the field electrode and the drift region, and having an opening, at least one of a field stop region and a generation region. |
| US08716787B2 |
Power semiconductor device and fabrication method thereof
A fabrication method of a power semiconductor device is provided. Firstly, a plurality of trenched gate structures is formed in the base. Then, a body mask is used for forming a pattern layer on the base. The pattern layer has at least a first open and a second open for forming at least a body region and a heavily doped region in the base respectively. Then, a shielding structure is formed on the base to fill the second open and line at least a sidewall of the first open. Next, a plurality of source doped regions is formed in the body region by using the pattern layer and the shielding structure as the mask. Then, an interlayer dielectric layer is formed on the base and a plurality of source contact windows is formed therein to expose the source doped regions. |
| US08716785B2 |
Method and system for metal gate formation with wider metal gate fill margin
A method includes providing a semiconductor substrate having a gate trench and depositing a metal layer, using a physical vapor deposition (PVD) process, over the substrate to partially fill the trench. The metal layer includes a bottom portion and a sidewall portion that is thinner than the bottom portion. The method also includes forming a coating layer on the metal layer, etching back the coating layer such that a portion of the coating layer protects a portion of the metal layer within the trench, and removing the unprotected portion of the metal layer. A different aspect involves a semiconductor device that includes a gate that includes a trench having a top surface, and a metal layer formed over the trench, wherein the metal layer includes a sidewall portion and a bottom portion, and wherein the sidewall portion is thinner than the bottom portion. |
| US08716784B2 |
Semiconductor device and associated fabrication method
A semiconductor device and a method for forming the semiconductor device wherein the semiconductor comprises: a trench MOSFET, formed on a semiconductor initial layer, comprising a well region, wherein the semiconductor initial layer has a first conductivity type and wherein the well region has a second conductivity type; an integrated Schottky diode next to the trench MOSFET, comprising a anode metal layer contacted to the semiconductor initial layer; a trench isolation structure, coupled between the trench MOSFET and integrated Schottky diode, configured to resist part of lateral diffusion from the well region; wherein the well region comprises an overgrowth part which laterally diffuses under the trench isolation structure and extends out of it. |
| US08716775B2 |
Semiconductor integrated circuit having reservoir capacitor
A semiconductor integrated circuit including a large capacity reservoir capacitor to provide suitable power is provided. The semiconductor integrated circuit includes a semiconductor substrate in which a cell area and a peripheral circuit area are defined, a MOS capacitor formed on the semiconductor substrate corresponding to the peripheral circuit area, and a dummy capacitor group formed on the peripheral circuit area to overlap the MOS capacitor. One electrode of the MOS capacitor and one electrode of the dummy capacitor group are connected to each other and the other electrode of the MOS capacitor and the other electrode of the dummy capacitor group are connected to difference voltage sources from each other. |
| US08716774B2 |
Semiconductor device having a buried gate type MOS transistor and method of manufacturing same
A semiconductor device includes a semiconductor substrate having a first gate groove having first and second sides opposite to each other; a first diffusion region underneath the first gate groove; a second diffusion region in the semiconductor substrate, the second diffusion region covering an upper portion of the first side of the first gate groove; and a third diffusion region in the semiconductor substrate. The third diffusion region covers the second side of the first gate groove. The third diffusion region is coupled to the first diffusion region. The third diffusion region has a bottom which is deeper than a bottom of the first gate groove. The bottom of the third diffusion region is different in level from the bottom of the first diffusion region. |
| US08716773B2 |
Dynamic memory device with improved bitline connection region
A semiconductor device includes a semiconductor substrate having a memory cell region and a peripheral circuit region; a bit line extending over the memory cell region and the peripheral circuit region, the bit line including a first portion in the peripheral circuit region; and a sense amplifier in the peripheral circuit region. The sense amplifier includes a transistor having a gate electrode which includes the first portion of the bit line. |
| US08716772B2 |
DRAM cell design with folded digitline sense amplifier
The present invention is generally directed to a DRAM cell design with folded digitline sense amplifier. In one illustrative embodiment, a memory array having a plurality of memory cells having an effective size of 6F2 is disclosed which has a plurality of dual bit active areas, each of the active areas having a substantially longitudinal axis, and a plurality of digitlines arranged in a folded digitline architecture, wherein the active areas are positioned such that the longitudinal axis of the active areas is oriented at an angle with respect to a centerline of the digitlines. |
| US08716771B2 |
Anti-reflection structures for CMOS image sensors
Optical structures having an array of protuberances between two layers having different refractive indices are provided. The array of protuberances has vertical and lateral dimensions less than the wavelength range of lights detectable by a photodiode of a CMOS image sensor. The array of protuberances provides high transmission of light with little reflection. The array of protuberances may be provided over a photodiode, in a back-end-of-line interconnect structure, over a lens for a photodiode, on a backside of a photodiode, or on a window of a chip package. |
| US08716769B2 |
Image sensors including color adjustment path
An image sensor includes a transfer transistor including a vertical gate portion extending in a depth direction of a substrate in an active region of the substrate and photodiode regions located at positions of different depths with respect to a top surface of the substrate in the active region. At least one color adjustment path extends between at least two photodiode regions of the photodiode regions and provides a charge movement path between the at least two photodiode regions. |
| US08716768B2 |
Transistor with self-aligned channel width
A device includes a transistor including a source and a drain disposed in a substrate and a gate disposed above the substrate. The gate includes a first longitudinal member disposed above the source and the drain and running substantially parallel to a channel of the transistor. The first longitudinal member is disposed over a first junction isolation area. The gate also includes a second longitudinal member disposed above the source and the drain and running substantially parallel to the channel of the transistor. The second longitudinal member is disposed over a second junction isolation region. The gate also includes a cross member running substantially perpendicular to the channel of the transistor and connecting the first longitudinal member to the second longitudinal member. The cross member is disposed above and between the source and the drain. |
| US08716767B2 |
Compliant bipolar micro device transfer head
A compliant bipolar micro device transfer head array and method of forming a compliant bipolar micro device transfer array from an SOI substrate are described. In an embodiment, a compliant bipolar micro device transfer head array includes a base substrate and a patterned silicon layer over the base substrate. The patterned silicon layer may include first and second silicon interconnects, and first and second arrays of silicon electrodes electrically connected with the first and second silicon interconnects and deflectable into one or more cavities between the base substrate and the silicon electrodes. |
| US08716765B2 |
Contact structure of semiconductor device
A contact structure for a semiconductor device includes a substrate comprising a major surface and a cavity. A bottom surface of the cavity is lower than the major surface. The contact structure also includes a strained material in the cavity, and a lattice constant of the strained material is different from lattice constant of the substrate. The contact structure also includes a first metal layer over the strained material, a dielectric layer over the first metal layer, and a second metal layer over the dielectric layer. The dielectric layer has a thickness ranging from 1 nm to 10 nm. |
| US08716764B2 |
Semiconductor device and manufacturing method thereof
A semiconductor device and a manufacturing method thereof are provided. The fin semiconductor device includes a fin formed on a substrate and an insulating material layer formed on the substrate and surrounding the fin. The fin has a semiconductor layer that has a source region portion and a drain region portion. The fin includes a first channel control region, a second channel control region, and a channel region between the two channel control regions, all of which are positioned between the source region portion and the drain region portion. The two channel control regions may have the same conductivity type, different from the channel region. |
| US08716761B2 |
Image sensor for semiconductor light-sensitive device, manufacturing thereof, image processing apparatus using the same, and method for detecting color signal
An image sensor for a semiconductor light-sensitive device including a semiconductor substrate and a light receiving device configured to receive light and generate a signal from the light. The image sensor may include an electron collecting device formed in the semiconductor substrate to receive at least a portion of the electrons generated by the light in the light receiving device. The image sensor may include a first type device isolation film configured to isolate the light receiving device from the electron collecting device. The image sensor may include a shielding film formed over the semiconductor substrate and configured to shield the first electron collecting device from the light. |
| US08716752B2 |
Structure and method for making a strained silicon transistor
A graded SiGe sacrificial layer is epitaxially grown overlying a silicon substrate. A single crystal silicon layer is then grown by an epitaxial process overlying the graded SiGe layer. A SiGe layer is next grown by an epitaxial process as a single crystal layer overlying the silicon layer. A subsequent silicon layer, which becomes the active silicon layer for the transistors, is epitaxially grown overlying the second silicon germanium layer. Together the epitaxially grown Si, SiGe and Si layers form a laminate semiconductor structure. A MOS transistor is then formed on the active area of the single crystal silicon. The graded SiGe sacrificial layer is removed by an etch process to electrically isolate the laminate semiconductor structure from the substrate. |
| US08716751B2 |
Methods of containing defects for non-silicon device engineering
An apparatus including a device including a channel material having a first lattice structure on a well of a well material having a matched lattice structure in a buffer material having a second lattice structure that is different than the first lattice structure. A method including forming a trench in a buffer material; forming an n-type well material in the trench, the n-type well material having a lattice structure that is different than a lattice structure of the buffer material; and forming an n-type transistor. A system including a computer including a processor including complimentary metal oxide semiconductor circuitry including an n-type transistor including a channel material, the channel material having a first lattice structure on a well disposed in a buffer material having a second lattice structure that is different than the first lattice structure, the n-type transistor coupled to a p-type transistor. |
| US08716750B2 |
Semiconductor device having epitaxial structures
A semiconductor device having epitaxial structures includes a gate structure positioned on a substrate, epitaxial structures formed in the substrate at two sides of the gate structure, and an undoped cap layer formed on the epitaxial structures. The epitaxial structures include a dopant, a first semiconductor material having a first lattice constant, and a second semiconductor material having a second lattice constant, and the second lattice constant is larger than the first lattice constant. The undoped cap layer also includes the first semiconductor material and the second semiconductor material. The second semiconductor material in the epitaxial structures includes a first concentration, the second semiconductor material in the undoped cap layer includes at least a first concentration, and the second concentration is lower than the first concentration. |
| US08716747B2 |
Semiconductor device
A diode region and an IGBT region are formed in a semiconductor layer of a semiconductor device. A lifetime controlled region is formed in the semiconductor layer. In a plan view, the lifetime controlled region has a first lifetime controlled region located in the diode region and a second lifetime controlled region located in a part of the IGBT region. The second lifetime controlled region extends from a boundary of the diode region and the IGBT region toward the IGBT region. In the plan view, a tip of the second lifetime controlled region is located in a forming area of the body region in the IGBT region. |
| US08716742B2 |
Light emitting device for AC operation
A light emitting device includes a substrate, a plurality of rectifier diodes, and at least one light emitting diode (LED) module. The substrate has a first cavity, a second cavity, and a third cavity formed thereon. The rectifier diodes are arranged in the first cavity and the third cavity respectively. The LED module is arranged in the second cavity. The LED module includes a plurality of LEDs. The light emitting device is capable of rectifying and converting an alternating current (AC) power supply to drive the LEDs to emit light. |
| US08716739B2 |
Optical electronic package with an optically isolated chamber
A package includes a substrate with an attached emitting IC chip and receiving IC chip. The emitting IC chip includes an optical emitter, and the receiving IC chip includes a main optical sensor and a secondary optical sensor. A case is provided with a bottom portion and a peripheral wall portion to cover the IC chips, wherein the edge of the peripheral wall portion is mounted to the substrate. The bottom portion of the case includes a main opening above the main optical sensor and a secondary opening above the optical emitter. An opaque material is interposed between the case and the receiving IC chip to isolate the main optical sensor from the secondary optical sensor and delimiting a chamber containing the secondary optical sensor and the optical emitter. The chamber is optically isolated from the main optical sensor and main opening, and may be filled with a transparent material. |
| US08716736B2 |
Surface light emitting device
The surface light emitting device includes an organic EL element, a protection substrate, a protection part, and a light extraction structure part. The element has a first face and a second face opposite to the first face, and emits light from the first face. The substrate has transparency for light emitted from the element, and is placed facing the first face, and has a primary surface facing the first face of the element. The protection part is placed facing the second face of the element, and constitutes a housing in combination with the substrate and accommodates the element so as to protect the element from water. The structure part is interposed between the first face of the element and the substrate, and suppresses reflection of light emitted from the element on at least one of the first face of the element and the primary surface of the substrate. |
| US08716734B2 |
Light emitting diode package having a portion of reflection cup material covering electrode layer on side surfaces of substrate
An LED package includes a substrate, an electrode layer, a light-emitting chip, a reflection cup and an encapsulation. The substrate includes a first surface, an opposite second surface, and two side surfaces. The electrode layer is consisted of a positive electrode and a negative electrode, each of which extends from the first surface to the second surface via a respective side surface. The light-emitting chip is located on the first surface of the substrate and electrically connected to the electrode layer. The reflection cup comprises a first part covering the electrode layer on the side surfaces of the substrate, a second part with a bowl-like shape on the first surface of the substrate and surrounding the light-emitting chip. The encapsulation is filled in the second part of the reflection cup. |
| US08716732B2 |
Light emitting element
A light emitting element includes a semiconductor laminate structure including a first semiconductor layer of a first conductivity type, a light emitting layer, and a second semiconductor layer of a second conductivity type different from the first conductivity type, a part of the second semiconductor layer and the light emitting layer being removed to expose a part of the first semiconductor layer, a first reflecting layer on the semiconductor laminate structure and including an opening, the opening being formed in the exposed part of the first semiconductor layer, a transparent wiring electrode for carrier injection into the first semiconductor layer or the second semiconductor layer through the opening, a second reflecting layer formed on the transparent wiring electrode and covering a part of the opening so as to reflect light emitted from the light emitting layer and passing through the opening back to the first semiconductor layer. |
| US08716731B2 |
Tunable phosphor for luminescent
The present disclosure provides an illuminating system including a light emitting diode (LED); and a tunable luminescent material disposed approximate the light-emitting diode, wherein the tunable luminescent material includes alkaline earth metal (AE) and silicon aluminum nitride doped by a rare earth element (RE), formulated as (AE)Si6−pAlpN8, wherein p is a parameter defining a relative aluminum content in weight and p is greater than zero. |
| US08716729B2 |
Lighting device
A lighting device (1) comprises at least one element (2) emitting light which is at least in part visible, and at least one conversion medium (3), which converts at least part of the radiation emitted by the element (2) into radiation of another frequency. In addition, the lighting device (1) comprises at least one filter medium (4) which filters at least part of the radiation, and which is configured such that the quantity of the conversion medium (4) to be used is reduced for at least one predetermined color saturation and/or one predetermined hue. This means that, compared with a light source corresponding to the lighting device (1) apart from the filter medium (4), savings are made in conversion medium (3) while achieving the same color saturation or the same hue. Light of a predetermined color saturation or of a predetermined hue may be efficiently generated by such a lighting device (1) and the lighting device (1) may be inexpensively produced. In operation, it also has high light intensities and a long service life. |
| US08716724B2 |
Optoelectronic projection device
An optoelectronic projection device which generates a predefined image during operation, including a semiconductor body having an active layer that generates electromagnetic radiation and a radiation exit side and is an imaging element of the projection device, wherein, to electrically contact the semiconductor body, a first contact layer and a second contact layer are arranged at a rear side of the semiconductor body, the rear side lying opposite the radiation exit side, and are electrically insulated from one another by a separating layer. |
| US08716719B2 |
Solid-state imaging device, method of manufacturing solid-state imaging device, and electronic apparatus
Provided is a solid-state imaging device including: a first-conductivity-type substrate; a second-conductivity-type well formed in a surface side of the first-conductivity-type substrate; a photoelectric conversion area configured with a first-conductivity-type-impurity area formed in the second-conductivity-type well to convert incident light to charges; a first-conductivity-type-charge retaining area configured with the first-conductivity-type-impurity area formed in the second-conductivity-type well to retain the charges converted by the photoelectric conversion area until the charges are read out; a charge voltage conversion area configured with the first-conductivity-type-impurity area formed in the second-conductivity-type well to convert the charges retained in the charge retaining area to a voltage; and a first-conductivity-type-layer area configured by forming a first-conductivity-type-in a convex shape from a boundary between the first-conductivity-type substrate and the second-conductivity-type well to a predetermined depth of the surface side under at least one portion of the charge retaining area and the charge voltage conversion area. |
| US08716715B2 |
Thin film transistor substrate
A thin film transistor substrate including a thin film transistor having a drain electrode with an electrode portion, which overlaps with a semiconductor layer, and an extended portion, which extends from the electrode portion and has a portion overlapping with a storage electrode or storage electrode line. A passivation layer is arranged on the drain electrode, and it has a contact hole that partially exposes the extended portion of the drain electrode without exposing a step in the extended portion caused by the storage electrode or storage electrode line. A pixel electrode is arranged on the passivation layer and is electrically connected with the extended portion of the drain electrode through the contact hole. |
| US08716711B2 |
Thin-film transistor and thin-film diode having amorphous-oxide semiconductor layer
A thin-film transistor including a channel layer being formed of an oxide semiconductor transparent to visible light and having a refractive index of nx, a gate-insulating layer disposed on one face of the channel layer, and a transparent layer disposed on the other face of the channel layer and having a refractive index of nt, where there is a relationship of nx>nt. A thin-film transistor including a substrate having a refractive index of no, a transparent layer disposed on the substrate and having a refractive index of nt, and a channel layer disposed on the transparent layer and having a refractive index of nx, where there is a relationship of nx>nt>no. |
| US08716709B2 |
Display device
The present invention provides an inexpensive display device that includes an ion sensor portion and a display and that can be miniaturized. The present invention is a display device that includes an ion sensor portion including an ion sensor circuit and a display including a display-driving circuit. The display device has a substrate, and at least one portion of the ion sensor circuit and at least one portion of the display-driving circuit are formed on the same main surface of the substrate. |
| US08716708B2 |
Semiconductor device and method for manufacturing the same
Provided is a bottom-gate transistor including an oxide semiconductor, in which electric-field concentration which might occur in the vicinity of an end portion of a drain electrode layer (and the vicinity of an end portion of a source electrode layer) when a high gate voltage is applied to a gate electrode layer is reduced and degradation of switching characteristics is suppressed, so that the reliability is improved. The cross-sectional shape of an insulating layer which overlaps over a channel formation region is a tapered shape. The thickness of the insulating layer which overlaps over the channel formation region is 0.3 μm or less, preferably 5 nm or more and 0.1 μm or less. The taper angle θ of a lower end portion of the cross-sectional shape of the insulating layer which overlaps over the channel formation region is 60° or smaller, preferably 45° or smaller, further preferably 30° or smaller. |
| US08716707B2 |
Electronic device
A device is prepared using a chemical vapor deposition method and has a patterned thin film on a substrate that is applied using a deposition inhibitor material. The deposition inhibitor material is a hydrophilic polymer that is a neutralized acid having a pKa of 5 or less, wherein at least 90% of the acid groups are neutralized. The deposition inhibitor material can be patterned simultaneously or subsequently to its application to the substrate, to provide selected areas of the substrate effectively not having the deposition inhibitor material. A thin film is substantially deposited only in the selected areas of the substrate not having the deposition inhibitor material. |
| US08716702B2 |
Organic light-emitting display device and method of manufacturing the same
An organic light-emitting display device includes: a buffer layer including sequentially stacked materials having different refractive indexes on a substrate; source and drain electrodes on the buffer layer; a first active layer of a thin film transistor between the source and drain electrodes, and a second active layer spaced from the first active layer at a same layer as and including a same material as the first active layer; a first insulation layer on the buffer layer, the source and drain electrodes, the first and second active layers, and including sequentially stacked materials having different refractive indexes; a first gate electrode corresponding to a center region of the first and second active layers with the first insulation layer therebetween, and a pixel electrode at a same layer as and comprising a same material as the first gate electrode; and a second gate electrode on the first gate electrode. |
| US08716697B2 |
Electronic devices made with crosslinkable compounds and copolymers
The present disclosure relates to electronic devices comprising at least one layer comprising novel cross-linkable polymers. The compounds can function as monomers, and copolymers can be formed from such monomers, such copolymers comprising, as polymerized units, a plurality of units of the compounds. The compositions are especially useful when incorporated into charge transport layers and light-emitting layers of a wide variety of electronic devices. |
| US08716696B2 |
Organic semiconductor thin film transistor and method of fabricating the same
A substrate having a thin film transistor includes a buffer layer on a substrate, source and drain electrodes on the buffer layer, a portion of the buffer layer exposed between the source and drain electrodes, a small organic semiconductor layer on the source electrode and the drain electrode, the organic semiconductor layer contacting the exposed portion of the buffer layer, a gate insulating layer on the organic semiconductor layer, the gate insulating layer having substantially the same size as the organic semiconductor layer, a gate electrode on the gate insulating layer, a passivation layer over the surface of the substrate including the gate electrode; and a pixel electrode on the passivation layer, the pixel electrode electrically connected to the drain electrode. |
| US08716689B2 |
Thermal diode device and methods
A thermal diode comprising a superlyophobic surface, and a lyophilic surface separated from the superlyophobic surface defining a chamber. A liquid is disposed in the chamber, the liquid capable of phase changing during operation of the thermal diode. Methods of cooling and insulating bodies and rectifying heat transfer using the thermal diode. |
| US08716688B2 |
Electronic device incorporating memristor made from metallic nanowire
An electronic device includes a first electrode, a second electrode and a nanowire connected between the first and second electrodes to allow electric current flow. The nanowire is made from a conductive material exhibiting a variable resistance due to electromigration. The nanowire is repeatably switchable between two states. A voltage clamp operates through feedback control to maintain the voltage across the nanowire and prevent thermal runaway. |
| US08716686B2 |
Canister for transporting and/or storing radioactive materials conferring enhanced heat transfer
A canister for transporting and/or storing radioactive materials, the canister comprising two concentric shells between which is housed a radiological protection device comprising at least a first and a second metal components adjacent along a circumferential direction. According to the invention, the first component is supported against the outer shell and at a distance from the inner shell, whereas the second component is supported against the shell and at a distance from the shell. In addition, the components are in contact with each other along an interface taking, in section along any plane orthogonal to the longitudinal axis and crossing this interface, the form of a straight line segment defining with a radial straight line crossing it at its centre an acute angle (A). |
| US08716683B2 |
Ion beam processing system and sample processing method
An ion beam processing system (100) processes the sample (S) mounted on a sample stage (30) by irradiating the sample with an ion beam in a sample chamber (2). The system has a sample container (20) including a cover portion (26) formed to be detachably mountable to a base portion (24), the sample stage (30) on which the container (20) is detachably mountable, and cover mounting/dismounting apparatus (40) for mounting and dismounting the cover portion (26) from outside the sample chamber (2). |
| US08716681B1 |
Sample processing method
In one embodiment, a sample processing method includes placing a sample on a sample placing module, and setting first processing boxes on one side of slice formation scheduled regions of the sample, and second processing boxes on the other side thereof. The method includes processing the sample by performing a primary scan which sequentially scans the first processing boxes with a continuously generated ion beam, and a secondary scan which sequentially scans the second processing boxes with a continuously generated ion beam, to form slices of the sample. The primary and secondary scans are performed so that a first scanning condition for scanning first regions within the first and second processing boxes is set different from a second scanning condition for scanning second regions between the first processing boxes and between the second processing boxes, to allow frame portions of the sample to remain in the second regions. |
| US08716680B2 |
System and method for reducing trapped energetic proton or energetic electron flux at low earth orbits
A system and method for improving the survivability of space systems following a High Altitude Nuclear Explosion (HANE) incident resulting in energetic electrons being trapped in the inner radiation belt of Earth is disclosed. The ULF electromagnetic waves is generated by space or ground based transmitters and the frequency range is selected such that the injected waves are in gyrofrequency resonance with trapped energetic particles. The Radiation Belt Remediation (RBR) depends on the wave-number of the injected waves and the wave-number of the injected waves increases along their propagation path when they approach the cyclotron frequency of the dominant or minority ions 0+, He+ and H+. |
| US08716667B2 |
Switching apparatus, switching method, and electronic device
The present invention relates to a switching apparatus, a switching method, and an electronic device with which it is possible to detect whether or not a proximal object is a human skin. |
| US08716657B2 |
High sensitivity mass spectrometry systems
A high sensitivity desorption electrospray ionization mass spectrometry system that employs a heated platform, along with means for directing a liquid stream containing an analyte of interest onto a target location on the heated platform to heat the stream, an electrospray emitter for generating an electrospray and directing the electrospray at the target location on the heated platform to produce an ionized, desorbed analyte, and a mass spectrometer for receiving and detecting the ionized, desorbed analyte. |
| US08716655B2 |
Integrated ion separation spectrometer
An apparatus including an ion injector having an inlet and an outlet and a micro-corona ionizer positioned between the inlet and the outlet of the ion injector. A drift and separation channel having a first end and a second end is positioned with the first end coupled to outlet of the ion injector, and an ion detector is coupled to the second end of the ion separation and drift channel. Other embodiments are disclosed and claimed. |
| US08716653B2 |
Sample analysis and ion detection
Various embodiments of ion detection systems, devices, and associated methods of operation are described herein. In one embodiment, a method for ion detection includes separating a target species from other species in an ionized sample of a first polarity, generating ions of a second polarity opposite the first polarity, and contacting ions of the second polarity with the ionized sample to generate emissions after separating the target species from other species in the ionized sample. The method also includes detecting the generated emissions when combining the ionized sampled of the first polarity with the ions of the second polarity. |
| US08716652B2 |
Method for homogenization of the threshold values of a multi-channel, quanta-counting radiation detector
A method is disclosed for homogenization of threshold values of a multichannel, quanta-counting radiation detector. In an embodiment of the method empty measurements are carried out with the detector at different spectral compositions of the radiation with different settings of threshold values of the comparators. For each channel of which the comparators is to be set to the same energy threshold, an adapted threshold value is determined for this energy threshold from the empty measurement, at which a variation of the normalized count rate of the channel is minimized over the different spectral compositions of the radiation. This avoids problems in the further processing of the measurement data of the detector, which can occur during alterations of the spectrum. |
| US08716650B2 |
Nuclear gauges and related methods of assembly
Nuclear gauges, their components and method for assembly and adjustment of the same are provided. The nuclear gauges are used in measuring the density and/or moisture of construction-related materials. The nuclear gauge can include a gauge housing having a vertical cavity therethrough and at least one radiation detector located within the housing. The nuclear gauge can include a vertically moveable source rod and a radiation source operatively positioned within a distal end of the source rod. |
| US08716648B2 |
Photon detection system and method of photon detection
According to one embodiment, a photon detection system determines the number of detected photons. The detection system includes an avalanche photodiode and a measuring unit. The measuring unit measures an avalanche signal induced by illumination before the avalanche current through the device has saturated. |
| US08716647B2 |
Analog silicon photomultiplier using phase detection
An analog silicon photomultiplier system includes at least one analog pixel comprising a plurality of analog photodiodes (APDs), and a capacitor, a signal generator, a phase detector, and a compensation network. The signal generator is configured to generate and propagate a sinusoidal signal concurrently along first and second transmission lines. A capacitor is loaded on the first transmission line when an APD corresponding to the capacitor detects a photon. The phase detector is coupled with the first and second transmission lines, determines a phase difference between the first transmission line and the second transmission line and calculates a number of APDs that have fired from the phase difference. The compensation network is coupled with the second transmission line and the phase detector, and comprises a plurality of compensation capacitors, wherein the compensation capacitors are loaded on the second transmission line in proportion to the number of APDs that have fired. |
| US08716646B2 |
Photoelectric conversion device and method for operating the same
In a photoelectric conversion device including a photodiode and a current mirror circuit, a diode-connected transistor is provided in parallel with the photodiode. The transistor serves as a leakage path for rapidly discharging charge stored in the gate capacitance in the current mirror circuit. Thus, the response speed of the photoelectric conversion device is increased, and output of an abnormal value is reduced. |
| US08716633B2 |
Method for manufacturing PTC device and system for preventing overheating of planar heaters using the same
Disclosed are a method for manufacturing a positive temperature coefficient (PTC) device and a system for preventing overheating of a planar heater using the same. The manufacturing of the positive temperature coefficient (PTC) device is performed by mixing one or more polymer resins selected from ethylene butyl acrylate copolymers, ethylene vinyl acetate copolymers and polyethylene oxide, carbon black and an additive to prepare a compounding composition, adhering an electrode to both surfaces of the compounding composition, compressing the resulting electrode structure into a sheet, and irradiating electron beams to the sheet to perform cross-linking. Also, disclosed is a planar heater overheating prevention sensor cable obtained by connecting a plurality of PTC devices in series and adhering the devices to the surface of a planar heater by a predetermined distance. The PTC overheating prevention sensor cable is bent in one direction and adhered to a region in which a planar heater is arranged, thus having a structure in which the PTC devices are randomly dispersed in the form of a dot. The system for preventing overheating of a planar heater controls electric current transfer of the planar heater, when overheating occurs in or around the region in which PCT devices are adhered due to abnormal operation and thus prevents the overheating, thereby exhibiting improved safety, high installment and construction efficiency, decreased energy loss and superior durability. |
| US08716629B2 |
Temperature sensor for body temperature measurement
This invention relates to a temperature sensor for body temperature measurements. The temperature sensor is made of several layers, where a first layer has a central heater embedded therein, a second layer which is attached to the first layer has at least one first thermistor embedded therein for measuring a first temperature value, a third layer has at one ore second thermistor embedded therein separated from the first thermistor for measuring at least one second temperature value, but this third layer is adapted to be in contact to the skin of the surface of the body for conducting the heat escaping from the body through the layers. The difference between the first and the second temperature values indicates the heat flux from the body. The heat emitted from central heater is tuned oppositely to the heat flux until a zero heat flux is reached, where the temperature at the at least one second thermistor at zero heat flux indicates the body temperature. These layers are fabric layers. |
| US08716625B2 |
Workpiece cutting
In some aspects, methods includes forming intersecting apertures in a workpiece with a laser beam by moving the laser beam along intersecting line paths, and cutting out a portion of a shape from the workpiece by moving the laser beam along a continuous final path extending around an intersection point of the intersecting line paths. |
| US08716624B2 |
Method for forming tubular beam with center leg
A roll former for forming a sheet into a continuous multi-tubular reinforcement beam. The roll former includes a first set of rollers that are configured to bend the sheet to form a common center wall in generally perpendicular orientation relative to first and second lateral portions of the sheet that extend in opposing directions from respective first and second radiused ends of the common center wall. The first set of rollers also form radiused edges on the first and second lateral portions. A second set of rollers is configured to form a channel rib longitudinally along each of the first and second lateral portions. A third set of rollers is configured to bend the first and second lateral portions simultaneously and equally to abut the first and second radiused edges with the respective first and second radiused ends of the common center wall to define adjacent tubes of the beam. |
| US08716622B2 |
Apparatus and method for performing laser welding operations
A laser welding apparatus and method reproduces a welding state substantially identical to an actual operation of a robot at a manufacturing site even when an operating speed of the robot is changed. When a moving speed of the robot is, for example, 50% of an override ratio, a welding point speed, which is a resultant speed of a focus moving speed of the laser beam by movement of the robot having a scanner head and the focus moving speed of the laser beam by rotation of the laser scanning mirror, becomes identical to that when an override ratio is 100%. This is achieved by increasing a rotating speed of a laser scanning mirror within the scanner head. |
| US08716621B2 |
Head for the continuous precision machining on three-dimensional bodies and machining equipment that comprises said head
A head for the continuous precision machining on three-dimensional bodies includes a fastening means to a flange of a machining equipment, having a first mechanical rotation axis, an intermediate means having a second mechanical rotation axis in series to the first mechanical rotation axis. The second mechanical rotation axis is orthogonal to the first mechanical rotation axis which intersects at a point of intersection. A terminal processing means has in series with the first and second mechanical rotation axes a third mechanical translating axis. The intermediate means has an arc configuration of a circumference with its centre at the point of intersection. The first mechanical rotation axis and the third mechanical translating axis are radially oriented to the arc. |
| US08716619B2 |
MEMS switch
A MEMS switch in which at least first, second and third signal lines are provided over the substrate, which each terminate at a connection region. A lower actuation electrode arrangement is over the substrate. A movable contact electrode is suspended over the connection regions for making or breaking electrical contact between at least two of the three connection regions and an upper actuation electrode provided over the lower actuation electrode. The use of three of more signal lines enables a symmetrical actuation force to be achieved or enables multiple switch functions to be implemented by the single movable electrode, or both. |
| US08716609B2 |
Weighing apparatus and roll-off truck, and associated method
An improved method of determining the weight of the contents of a container involves using a roll-off truck's own container loading system to remove a container from a number of weight measure elements. Another improved method of weighing the contents of a container involves employing support elements which enable a container that is engaged with the number of weight measurement elements to be lowered out of engagement with such weight measurement elements. An improved weighing apparatus includes a number of weight measurement elements and a number of support elements. Such an improved weighing apparatus can be retrofitted onto an existing truck to provide an improved truck on which such methods can be performed. |
| US08716605B2 |
Structure for shorting line connecting signal lines of flat panel display device
A shorting line connecting first and second signal lines arranged in parallel with each other in a flat panel display device is disclosed. The shorting line includes a first branch portion connected with the first signal line and branched from the first signal line toward the second signal line; a second branch portion connected with the second signal line and extended from the second signal line toward the first signal line; and a connection portion connecting the first branch portion to the second branch portion, wherein one end of the connection portion is connected with the first branch portion at a first angle, and another end of the connection portion is connected with the second branch portion at a second angle. |
| US08716604B2 |
Metal core wiring board and electric junction box having the same
An electric junction box including a metal core wiring board having a high heat-releasing property is provided. The electric junction box includes a case and a metal core wiring board received inside the case. The metal core wiring board includes a base plate and a plurality of relays. The base plate is constituted of a pair of insulation sheets sandwiching respective body portions of two conductive plates and body portions of a plurality of conductive plates. The each conductive plate has a terminal portion formed continuously from the body portion and arranged to project from edge of the insulation sheet. The conductive plates are made of copper alloy including copper and at least one of iron, nickel, tin and zirconium. |
| US08716603B2 |
Printed wiring board with dielectric material sections having different dissipation factors
An apparatus including a first printed wiring board section and a second printed wiring board section. The first printed wiring board section includes a first dielectric material layer. The first dielectric material layer has a first dissipation factor. The second printed wiring board section is directly attached with the first printed wiring board section to form a unitary printed wiring board structure. The second printed wiring board section includes a second dielectric material layer and an antenna on the second dielectric material layer. The second dielectric material layer has a different second dissipation factor. |
| US08716601B2 |
Corona resistant high voltage bushing assembly
A corona resistant high voltage bushing assembly includes an insulating sleeve to surround a conductor, a flange located on an outside surface of the insulating sleeve, and a first band of semiconductive glaze located on the outer surface of the insulating sleeve spaced apart from an end of the insulating sleeve. |
| US08716596B1 |
Solar cell having silicon nano-particle emitter
A silicon solar cell having a silicon substrate includes p-type and n-type emitters on a surface of the substrate, the emitters being doped nano-particles of silicon. To reduce high interface recombination at the substrate surface, the nano-particle emitters are preferably formed over a thin interfacial tunnel oxide layer on the surface of the substrate. |
| US08716594B2 |
High efficiency photovoltaic cells with self concentrating effect
Novel structures of photovoltaic cells (also called as solar cells) are provided. The Cells are based on the micro (or nano) structures which could not only increase the surface area but also have the capability of self concentrating the solar spectrum incident onto the cell. These photovoltaic cells have large power generation capability per unit physical area over the conventional cells. These cells will have enormous applications such as in space, in commercial, residential and industrial applications. |
| US08716591B2 |
Array of monolithically integrated thin film photovoltaic cells and associated methods
A process of forming an array of monolithically integrated thin film photovoltaic cells from a stack of thin film layers formed on an insulating substrate includes forming at least one cell isolation scribe in the stack of thin film layers. A second electrical contact layer isolation scribe is formed for each cell isolation scribe adjacent to a respective cell isolation scribe. A via scribe is formed in the stack of thin film layers between each cell isolation scribe and its respective second electrical contact layer isolation scribe. Insulating ink is disposed in each cell isolation scribe, and conductive ink is disposed in each via scribe to form a via. Conductive ink is also disposed along the top surface of the stack of thin film layers to form at least one conductive grid. |
| US08716590B2 |
Stacked solar cell device
This stacked solar battery device includes a plurality of solar battery units 4, an enclosure case made of a metal plate to house these solar battery units 4 therein, a cover glass having a partial cylindrical lens formed. The plurality of solar battery units 4 are housed in a plurality of recesses of the enclosure case, and are sealed with a sealing material of synthetic resin. The solar battery unit 4 has a planar light receiving solar battery module 10, and rod light receiving solar battery modules 30 and 50 stacked so that the module having a shorter center wavelength of the sensitivity wavelength band is positioned closer to the incident side of the sunlight. The solar battery module 10 is configured so that five planar light receiving solar-battery cells 11 are connected in parallel with four connection rods 20a and 20b, and the sunlight modules 30 and 50 are configured so that five sub modules 31 and 51 are connected in parallel respectively with the connection rods 40a, 40b, 60a and 60b. The sub modules 31 and 51 are configured so that a plurality of rod-shaped solar battery cells 32 and 52 respectively are connected in series. |
| US08716583B2 |
Musical learning and interaction through shapes
The present invention extends to methods, systems, and computer program products for musical learning and interaction. Embodiments include presenting a grouping of keys that share the same tonal context, and that have a tonal context that fits with a particular song. A user is prompted to provide user input, while the particular song is being played, using any order of keys selected from the particular key grouping. User input is received and is used as part of a music lesson and/or as part of a remix of the particular song. In addition, a musical instrument includes a centered keyboard, which include top keys and bottom keys that are pressable to produce musical notes and that are symmetrically centered about the axis of symmetry. |
| US08716576B1 |
Maize inbred PH1K93
A novel maize variety designated PH1K93 and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1K93 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1K93 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1K93 or a locus conversion of PH1K93 with another maize variety. |
| US08716568B2 |
Soybean variety A1035869
The invention relates to the soybean variety designated A1035869. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1035869. Also provided by the invention are tissue cultures of the soybean variety A1035869 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1035869 with itself or another soybean variety and plants produced by such methods. |
| US08716567B2 |
Soybean cultiver NE2412487
The present invention is in the field of soybean variety NE2412487 breeding and development. The present invention particularly relates to the soybean variety NE2412487 and its progeny, and methods of making NE2412487. |
| US08716565B2 |
Soybean cultivar WN0913501
The present invention is in the field of soybean variety WN0913501 breeding and development. The present invention particularly relates to the soybean variety WN0913501 and its progeny, and methods of making WN0913501. |
| US08716563B2 |
Soybean cultivar WN0912882
The present invention is in the field of soybean variety WN0912882 breeding and development. The present invention particularly relates to the soybean variety WN0912882 and its progeny, and methods of making WN0912882. |
| US08716558B2 |
Method of altering glycosylation of proteins in response to nojirimycin glucuronide in a plant cell expressing glucuronidase
Novel pro-drugs and methods for their use to alter the growth and biological characteristics of living cells, tissues, or whole organisms are described. Such cells may include animal cells, plant cells and bacterial cells. The methods allow for selective activation of the pro-drugs at or near transformant host cells expressing a gene for an enzyme that activates the pro-drugs. Pro-drugs according to a preferred embodiment of the invention are conjugates of a bioactive compound and a chemical group that is capable of being cleaved from the bioactive compound by action of an enzyme. Methods according to this invention include, (a) introducing into targeted cells a gene encoding an enzyme and (b) administering a pro-drug, wherein the enzyme releases the pro-drug from conjugation. In a preferred embodiment of the invention, the gene encoding the enzyme is a marker gene. Methods according to a preferred embodiment of the invention include altering protein production in a plant cell such as altering glycosylation of a protein produced by the plant cell. |
| US08716556B2 |
Use of MYB96 gene from Arabidopsis thaliana to increase cuticular wax biosynthesis
A method for increasing cuticular wax biosynthesis of plant includes transforming a plant cell with the recombinant vector containing MYB96 (myb domain protein 96) gene from Arabidopsis thaliana. A method for producing a transgenic plant with increased cuticular wax biosynthesis includes transforming a plant cell with the recombinant vector containing the MYB96 gene, and regenerating the transformed plant cell into the transgenic plant. A plant and a seed with increased cuticular wax biosynthesis are produced by the method. A method for producing a biofuel using a cuticular wax includes separating and purifying a cuticular wax from the plant. A composition for increasing cuticular wax biosynthesis of plant includes the MYB96 gene. |
| US08716554B2 |
Plants resistant to cytoplasm-feeding parasites
The present invention relates to transgenic plants resistant to parasites that their normal life cycle includes feeding on the plant cytoplasm, including insects, nematodes and fungi, wherein the plants are engineered to produce small interfering RNAs (siRNAs) capable of silencing a parasite specific gene. Particularly the parasite gene is a stage-specific gene, more particularly a gene involved in essential, early developmental stages of the parasite in or on the plant. |
| US08716545B1 |
Methods and apparatuses for separating toluene from multiple hydrocarbon streams
Methods and apparatuses for separating toluene from multiple hydrocarbon streams are provided. A method includes fractionating a first hydrocarbon stream, which includes benzene-depleted fractionation bottoms from benzene fractionation, in a first fractionation zone into a first fractionation overhead stream that includes toluene and a first fractionation bottoms. A second hydrocarbon stream, which includes toluene and is substantially free of compounds having a higher vapor pressure than toluene, is fractionated in a second fractionation zone into a second fractionation overhead stream including toluene and a second fractionation bottoms. The second fractionation zone is in liquid isolation from and in vapor communication with the first fractionation zone. The first fractionation bottoms are removed from the first fractionation zone, and the second fractionation bottoms are removed from the second fractionation zone separate from the first fractionation bottoms. The first fractionation overhead stream and the second fractionation overhead stream are combined to produce a combined fractionation overhead stream. |
| US08716539B2 |
Method for producing substituted diamantanes
Dinitroxylated diamantanes are suitable for being reacted with nucleophiles to form the corresponding disubstituted diamantanes. Surprisingly, at least dinitroxylated or hydroxylated diamantanes are rearranged in the presence of a strong acid and at least 4,9-nitroxylated or hydroxylated diamantanes are created. On this basis, 4,9-substituted diamantanes are able to be produced in a targeted manner by reaction with further nucleophiles. Methods for producing at least disubstituted diamantanes include: (a) at least dinitroxylation, followed by the substitution of all nitroxy groups by a nucleophile; or (b) at least dinitroxylation, the subsequent rearrangement in the presence of a strong acid, after realized rearrangement all nitroxy groups are replaced by a nucleophile; or (c) at least dinitroxylation, then subsequent reaction with water (as nucleophile), and rearrangement of the at least dihydroxylated compound in the presence of a strong acid, all hydroxy groups being replaced by another nucleophile in the event of a successful rearrangement. |
| US08716531B2 |
Method for producing norbornene derivative
A method for producing a norbornene derivative includes forming a Mannich base represented by any of general formulae (5) to (7) by reacting a carbonyl compound represented by any of general formulae (1) to (3) and an amine compound represented by general formula (4) with each other in an acidic solvent, to thereby obtain a reaction liquid comprising the Mannich base in the acidic solvent, wherein the acidic solvent comprises a formaldehyde derivative and 0.01 mol/L or more of an acid represented by formula HX; reacting the Mannich base and a diene compound represented by general formula (8) with each other by adding an organic solvent, a base in an amount of 1.0 to 20.0 equivalents to the acid, and the diene compound to the reaction liquid, and then heating the reaction liquid, to thereby form the norbornene derivative represented by any of general formulae (9) to (11). |
| US08716527B2 |
2-substituted-p-quinone derivatives for treatment of oxidative stress diseases
Methods of treating or suppressing oxidative stress diseases including mitochondrial diseases, impaired energy processing disorders, neurodegenerative diseases and diseases of aging are disclosed, as well as compounds useful in the methods of the invention, such as 2- substituted-p-quinone derivatives as disclosed herein. |
| US08716526B2 |
Method for producing difluoroacetyl chloride
A production method of difluoroacetyl chloride according to the present invention includes a chlorination step of bringing a raw material containing at least either a 1-alkoxy-1,1,2,2-tetrafluoroethane or difluoroacetyl chloride into contact with calcium chloride at a reaction enabling temperature. A production method of 2,2-difluoroethyl alcohol according to the present invention includes a catalytic reduction step of causing catalytic reduction of the difluoroacetyl chloride obtained by the above production method. By these methods, the difluoroacetyl fluoride can be efficiently converted to the difluoroacetyl chloride and to the 2,2-difluoroethyl alcohol. |
| US08716525B2 |
Process for continuous recovering (meth) acrylic acid and apparatus for the process
The present invention relates to a method and apparatus for continuous recovery of (meth)acrylic acid, and more specifically to a method of continuous recovery of (meth)acrylic acid, including: conducting gas phase oxidation of at least one compound selected from the group consisting of propane, propylene, butane, i-butylene, t-butylene, and (meth)acrolein in the presence of a catalyst to obtain a mixed gas containing (meth)acrylic acid; quenching the (meth)acrylic acid-containing mixed gas to remove high boiling point by-products in the (meth)acrylic acid-containing mixed gas; contacting the high boiling point by-product-free (meth)acrylic acid-containing mixed gas with water or an aqueous solution to obtain an aqueous solution containing (meth)acrylic acid; and purifying the aqueous solution containing (meth)acrylic acid to obtain (meth)acrylic acid.The continuous recovery method of (meth)acrylic acid according to the presentA invention may significantly reduce energy consumption and continuously recover high purity (meth)acrylic acid with excellent production efficiency compared to the previous recovery methods. |
| US08716524B2 |
Optically active quaternary ammonium salt having axial asymmetry and process for producing a-amino acid and derivative thereof with the same
The present invention provides a compound of the following formula (I) below. This compound (I) can be produced by reacting a 2,2′-dimethylene bromide-1,1′-binaphthyl derivative, which can be produced by a relatively small number of processes, with an easily available secondary amine. This compound (I) is useful as a chiral phase-transfer catalyst. |
| US08716522B2 |
Acetic acid production from biomass pyrolysis
Methods are disclosed for producing, from renewable carbon sources, acetic acid in an economical manner. In particular, these methods are directed to the separation and recovery of acetic acid as a substantial product (e.g., as much as 5% by weight or more) of biomass pyrolysis. For a given commercial biomass pyrolysis unit, the acetic acid yield can represent a significant quantity of that used in a major industrial applications such as purified terephthalic acid (PTA) production. According to some embodiments, pyrolysis conditions and/or flow schemes advantageously improve the recovery of acetic acid for a given purity level. |
| US08716517B2 |
Method for producing diisocyanates by gas-phase phosgenation
A process for preparing diisocyanates by gas-phase phosgenation starting out from a feed stream comprising the corresponding diamines and a phosgene-comprising feed stream, in which the feed streams are separately converted into the gas phase and preheated to the reaction temperature of the gas-phase phosgenation, wherein the waste heat from a plant for preparing chlorine by heterogeneously catalyzed oxidation of hydrogen chloride by the Deacon process is utilized for this purpose, is proposed. |
| US08716511B2 |
Process for preparing organoalkoxyhydrosilanes
Process for preparing organoalkoxyhydrosilanes with a boron content less than 100 ppb and of the formula R1xHySi(OR2)z where x+y+z=4 and x, y, z are greater than or equal to 1, wherein, in a first step, a boron-contaminated organohalohydrosilane of the formula R1xHySiHalz where x+y+z=4, x, y, z are greater than or equal to 1, and R1 are linear or branched alkyl, cycloalkyl, aryl, alkenyl or arylalkyl radicals having 1 to 12 carbon atoms and Hal is F, Cl, Br or I, is subjected to a treatment with silica or aluminosilicate and the silica or the aluminosilicate is subsequently removed from the organohalohydrosilane in a second step and then the purified organohalohydrosilane is reacted with alcohol R2—OH where R2 is a methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-pentyl, isopentyl, neopentyl or tert-pentyl radical. |
| US08716509B2 |
Process for preparing ruthenium(0)-olefin complexes
The present invention relates to a process for preparing ruthenium(0)-olefin complexes of the (arene)(diene)Ru(0) type by reacting a ruthenium starting compound of the formula Ru(+II)(X)p(Y)q (in which X=an anionic group, Y=an uncharged two-electron donor ligand, p=1 or 2, q=an integer from 1 to 6), with a cyclohexadiene derivative or a diene mixture comprising a cyclohexadiene derivative, in the presence of a base. In this process, the arene bound in the (arene)(diene)Ru(0) complex is formed from this cyclohexadiene derivative by oxidation. Suitable ruthenium(II) starting compounds are, for example, RuCl2(acetonitrile)4, RuCl2(pyridine)4 or RuCl2(DMSO)4. The bases used are inorganic or organic bases. The ruthenium(0)-olefin complexes prepared by the process according to the invention have a high purity and can be used as precursors for homogeneous catalysts, for preparation of functional ruthenium- or ruthenium oxide-containing layers and for therapeutic applications. |
| US08716507B2 |
Iron(II) catalysts containing diimino-diphosphine tetradentate ligands and their synthesis
New hexa-coordinate iron (II) complexes comprising compounds of formula (I) are described. These compounds comprise a tetradentate ligand with donor atoms comprising nitrogen and phosphorus. These complexes are shown for the first time to be useful catalysts for the hydrogenation of ketones, aldehydes, or imines to produce alcohols or amines, and the asymmetric hydrogenation of prochiral ketones or imines to produce non-racemic alcohols or amines. The source of the hydrogen can be hydrogen gas or a hydrogen-donating molecule such as isopropanol or hydrogen-donating mixture such as formic acid and an amine depending on the structure of the catalyst. In certain embodiments, the axial ligands on the catalyst comprise organonitrile ligands, carbonyl ligands, isonitrile ligands, or combinations thereof. The catalysts and the preparation thereof are disclosed. A reaction using phosphine and diamine precursors that is templated by the iron ion is the preferred route to the catalysts. |
| US08716504B2 |
Epoxidation processes
The present invention provides rhenium-promoted epoxidation catalysts based upon shaped porous bodies comprising a minimized percentage of their total pore volume being present in pores having diameters of less than one micron, and a surface area of at least about 1.0 m2/g. Processes of making the catalysts and using them in epoxidation processes are also provided. |
| US08716503B2 |
Process for preparing divinylarene dioxides
A process for preparing a divinylarene dioxide including reacting (a) at least one divinylarene with (b) at least one oxidant in the presence of (c) at least one transition metal complex catalyst, and (d) optionally, in the presence of a solvent, and (e) optionally in the presence of a catalyst modifier under conditions to form a divinylarene dioxide product. |
| US08716494B2 |
Pyrrolidinone carboxamide derivatives
Pyrrolidinone carboxamide compounds are provided that are useful for inhibiting the binding of ligands to the ChemR23 receptor. |
| US08716493B2 |
Multicyclic compounds and the use thereof
The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer. |
| US08716488B2 |
Olefin metathesis catalysts
The present invention refers to novel ruthenium- and osmium-based catalysts for olefin metathesis reactions, particularly to catalysts having stereoselective properties. Z-selectivity is obtained by utilizing two mono-anionic ligands of very different steric requirement. In olefin metathesis reactions these catalysts selectively provide the Z-isomer of disubstituted olefinic products. |
| US08716486B2 |
2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases
Methods of treating or suppressing oxidative stress disorders including mitochondrial diseases, impaired energy processing disorders, neurodegenerative diseases and diseases of aging are disclosed, as well as compounds useful in the methods of the invention, such as 2-heterocyclylaminoalkyl-(p-quinone) derivatives. |
| US08716480B2 |
7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
The present invention relates to novel triazolo[4,3-a]pyridine derivatives of Formula (I) wherein all radicals are as defined in the claims. The compounds according to the invention are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (“mGluR2”), which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved. |
| US08716479B2 |
Methods for stereoselective reduction
The invention is directed to a method to reduce a C—C double bond of an enone of a steroidal compound to produce a mixture of β ketone product and α ketone product, comprising treating a solution or suspension of the steroidal compound in a solvent with hydrogen gas in the presence of a catalyst and a substituted pyridine. |
| US08716477B2 |
Crystalline forms of bosentan salts and processes for their preparation
The present invention relates to crystalline forms of bosentan salts and processes for their preparation.(FORMULA) |
| US08716475B2 |
2-aminopyrimidine modulators of the histamine H4 receptor
2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis. |
| US08716474B2 |
Method for producing 2,4,6-tris(hydroxyphenyl)-1,3,5-triazine compound
The present invention provides a method of producing 2,4,6-tris(hydroxyphenyl)-1,3,5-triazine compound in which no rapid solidification or the like occurs and generation of by-products is suppressed, thereby enabling to reduce decrease in the yield.Particularly, the present invention is a method of producing 2,4,6-tris(hydroxyphenyl)-1,3,5-triazine compound represented by the following Formula (1): wherein the reaction between cyanuric halide compound represented by the following Formula (2): and hydroxyphenyl compound represented by the following Formula (3): is carried out by using, as the reaction solvent, a solvent containing sulfolane as the main component in the presence of a Lewis acid at an amount of 0.3 to 0.7 equivalent with respect to 1 equivalent of halogen atom of the cyanuric halide compound represented by the Formula (2), or by using a mixed solvent of inert solvent and cycloalkyl alkyl ether represented by the following Formula (4): Z1—O—Z2. (4) |
| US08716472B2 |
Tripodal cyclohexane derivatives and their use as carbohydrate receptors
A tri-podal compound according to formula (I) wherein, each Z is the same and is a substituted or unsubstituted N-heteroaromatic single-, multiple-, or fused-ring; and each A is the same, and can represent a direct bond between the cyclohexane ring and Z, or a carboxamide group (—C(O)—N(H)—). Use of the compounds in combinatorial libraries, methods of making the tripodal compounds, sensor devices for detecting carbohydrate targets, and methods of using the tripodal compounds to detect carbohydrate targets in a sample are also disclosed. |
| US08716468B2 |
Process for preparing randomly-bonded polysaccharides
The invention relates to a process for preparing a randomly-bonded polysaccharide, comprising as ingredients a saccharide, a polyol and an acid serving as a catalyst, the process comprising the steps of feeding the ingredients into a reactor in order to dehydrate the fed ingredients to an essentially anhydrous syrup, polycondensating the essentially anhydrous syrup at elevated temperatures in the said reactor while removing the reaction water, wherein the reactor is a mixing kneader device with counter-acting blades, wherein during the feeding step the saccharide, the polyol and the acid serving as catalyst are simultaneously or consecutively fed to the reactor, and in that during the dehydratation and polycondensation step the free water and reaction water is removed from the mixing kneader device by kneading and mixing the fed ingredients and the subsequent essentially anhydrous syrup under reduced pressure in the reactor, and during the polycondensation the essentially anhydrous syrup is continuously kneaded in the kneader reactor until the required degree of polymerization is obtained. |
| US08716464B2 |
Compositions and methods for silencing Ebola virus gene expression
The present invention provides compositions comprising therapeutic nucleic acids (e.g., interfering RNA such as siRNA) that target Ebola virus (EBOV) gene expression and methods of using such compositions to silence EBOV gene expression. More particularly, the invention provides unmodified and chemically modified interfering RNA which silence EBOV gene expression and methods of use thereof, e.g., for preventing or treating EBOV infections caused by one or more EBOV species such as Zaire EBOV. The invention also provides serum-stable nucleic acid-lipid particles comprising one or more interfering RNA molecules, a cationic lipid, and a non-cationic lipid, which can further comprise a conjugated lipid that inhibits aggregation of particles. Methods of silencing EBOV gene expression by administering one or more interfering RNA molecules to a mammalian subject are also provided. |
| US08716462B2 |
Levels and/or sustainability of DNA-based gene expression
The invention encompasses methods for improving the level and/or sustainability of expression for a target nucleic acid in a eukaryotic cell comprising: (a) modifying the target nucleic acid to introduce or to comprise signals that limit or constrain the positions of nucleosome cores, and (b) introducing the modified target nucleic acid into the eukaryotic cell, wherein the modified target nucleic acid has improved levels and/or sustainability of expression compared to original unmodified nucleic acid. |
| US08716459B2 |
Isolated nucleic acid molecules encoding variant activin receptor polypeptides
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided. |
| US08716457B2 |
Nucleobase characterisation
The present invention provides modified nucleobase compounds, modified nucleic acid mimetic compounds and various uses thereof. In addition, the invention provides methods for nucleobase characterisation, SNP characterisation and nucleic acid sequencing. |
| US08716455B2 |
Genetic products differentially expressed in tumors and use thereof
The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which said genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor. |
| US08716453B2 |
Cystatin C, β2 microglobulin, α1 microglobulin and genes for same, antibody, and kit and method for diagnosis of feline nephropathy
Proteins respectively having the amino acid sequences represented by SEQ ID NOs: 1, 17 and 32; structural genes respectively encoding the proteins, preferably respectively having the nucleotide sequences represented by SEQ ID NOs: 2, 18 and 33; an antibody capable of specifically binding to feline-derived cystatin C, feline-derived β2 microglobulin or feline-derived α1 microglobulin; a kit for diagnosing feline nephropathy, containing the antibody of the present invention; and a method for diagnosing feline nephropathy using the antibody of the present invention. |
| US08716452B2 |
Fully human antibodies against human 4-1BB
Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject comprising administering a therapeutically effective amount of the antibody to said subject. |
| US08716450B2 |
Dual variable domain immunoglobulins and uses thereof
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease. |
| US08716449B2 |
Antibodies against human IL-12
The present invention relates to novel p75 heterodimer specific anti-human IL-12 antibodies that are characterized by a higher potency and greater efficacy in neutralizing human IL-12 bioactivity than known heterodimer specific IL-12 monoclonal antibodies. The heterodimer specific antibodies recognize one or more epitopes of the human IL-12 p75 heterodimer, but do not bind to the p40 subunit alone. The heterodimer specific IL-12 antibodies neutralize rhesus monkey IL-12 bioactivity with a potency similar to their potency for neutralizing human IL-12 bioactivity making them useful IL-12 antagonists for in vivo studies in the rhesus monkey. |
| US08716446B2 |
Biopolymer conjugates comprising an interleukin-11 analog
The present invention provides for biopolymer conjugates of an IL-11 analog (mIL-11) and a biocompatible polymer. The mIL-11 of the invention displays an enhanced resistance to acidolysis and shows increased stability as compared to rhIL-11. The conjugates of the present invention are characterized by a longer serum half-life and exhibit essentially no loss of activity as compared to the corresponding unconjugated mIL-11. |
| US08716445B2 |
Compositions comprising signal peptide-containing proteins
The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP. |
| US08716444B2 |
Method and apparatus for predicting susceptibility to a developmental disorder
The present invention provides a method of screening a subject for mutations in the TRAPPC9 gene that are associated with developmental disabilities. The present invention also provides proteins that are associated with developmental disabilities including a truncation of NIBP. Also provided are nucleotide sequences encoding such proteins and methods of screening subjects to identify nucleotide sequences or proteins associated with developmental disabilities. |
| US08716441B2 |
Ubiquitin binding polypeptides
The invention relates to Tandem Ubiquitin Affinity Entities (TUBES) which are fusion polypeptides comprising at least two ubiquitin binding domains connected to each other by non-naturally occurring spacer regions. The TUBES are capable of binding with high affinity to ubiquitin and to ubiquitylated polypeptides and are therefore suitable for the purification of ubiquitylated polypeptides from cellular extracts as well as for the identification of new ubiquitylated polypeptides. |
| US08716438B2 |
Matricryptic ECM peptides for tissue reconstruction
Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in or on a patient also are provided along with methods of growing and repairing bone. |
| US08716436B2 |
Mu opioid receptor agonist analogs of the endomorphins
The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and/or chronic pain. Embodiments of the invention are directed to cyclic pentapeptide and hexapeptide analogs of endomorphin that have (i) a carboxy-terminal extension with an amidated hydrophilic amino acid and (ii) a substitution in amino acid position 2. These peptide analogs exhibit decreased tolerance relative to morphine, increased solubility compared to similar tetrapeptide analogs, while maintaining favorable or improved therapeutic ratios of analgesia to side effects. |
| US08716435B2 |
Multibranched polyoxyalkylene compound and producing method thereof
A multibranched polyoxyalkylene compound represented by the following formula (1): wherein R1 is the same or different and is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are the same or different and are an oxyalkylene group having 2 to 4 carbon atoms, n and m are the same or different and are an average number of moles of the oxyalkylene group added, n represents 0 to 1000, m is the same or different and represents 10 to 1000, X represents a functional group capable of reacting with an amino group, a mercapto group, an aldehyde group, a carboxyl group, a triple bond, or an azide group to form a chemical bond, and L1 and L2 are the same or different and are a single bond, an alkylene group, or an alkylene group in which at least one bond selected from an ester bond, a urethane bond, an amide bond, an ether bond, and an amino is interposed. |
| US08716434B2 |
Aramid copolymer
The invention concerns polymer comprising 2-(4-amino phenyl)-5 (6) amino benzimidazole (DAPBI), PPD, and terephthaloyl dichloride, the polymer having a IPC peak block ratio of 1.52 to 1.56 and an inherent viscosity of greater than 2 dl/g. |
| US08716430B2 |
Aramid copolymer
The invention concerns polymer comprising residues of 2-(4-amino phenyl)-5 (6) amino benzimidazole (DAPBI), paraphenylene diamine (PPD), and terephthaloyl dichloride, made by a process comprising the steps of: (a) forming a slurry of b mole percent DAPBI and y mole percent PPD in a solvent system comprising organic solvent and c weight percent of an inorganic salt, wherein the inorganic salt is present in an amount of at least 5 weight percent of the organic solvent, DAPBI and PPD being present in an amount sufficient for providing a polymer solution having a weight percent solids of 12 percent or greater on a polymer basis; and (b) contacting the slurry of step a) with a stoichiometric amount of terephthaloyl dichloride to form a product comprising the polymer; wherein the sum of y+b is 100 and the product of b×c is 225 or greater. |
| US08716428B2 |
Fluorinated polyester compound, coating compositions comprising the compound and methods of making
An fluorinated polyester compound is disclosed. The fluorinated polyester compound can be made by combining ingredients comprising a hydroxyl terminated polyphenyl ether; a carboxylic acid terminated perfluoropolyether; an acid catalyst; and a solvent. A coating solution comprising the fluorinated polyester compound and a method of coating a substrate therewith are also disclosed. |
| US08716426B2 |
Method for preparing an allophanate, allophanate, and low-viscosity composition containing the allophanate
A process for the preparation of an allophanate of one or more identical or different isocyanates, compositions obtained by the process, and uses of the compositions are disclosed. The process comprises reacting an isocyanate with at least one monoalcohol comprising an ether or polyether functional group in the presence of a bismuth-comprising catalyst and a metal compound as co-catalyst. |
| US08716423B2 |
Polyethylene for rotomoulding
A novel polyethylene is devised which polyethylene is particularly advantageous for manufacturing rotomoulded articles. |
| US08716421B2 |
Norbornene-type formate monomers and polymers and optical waveguides formed therefrom
This invention discloses and claims a series of polycyclic monomers and polymers useful in the production of optical waveguides. The polymers of the invention comprise one or more repeating units represented by the formula (IV): Wherein m, X, R1 and R2 are as defined herein. The films formed from the polymers of this invention exhibit significant changes in refractive index (greater than or equal to 0.5%) after exposure to suitable actinic or thermal energy thereby having superior optical transmission performance, which is of importance for modern optical applications such as wave guiding and optical data storage. |
| US08716420B2 |
Amphiphilic polymers and nanocrystals coated therewith
An amphiphilic polymer (A) comprising repeat units of the general formulae (I), (II) and (III): or salts thereof, wherein R1 is H or methyl, R2 is an aliphatic moiety with a main chain of 3 to 30 carbon atoms and 0 to 3 heteroatoms selected from the group N, O, S, Se and Si, and R3 is one of (i) an alicyclic moiety with a main chain of 5 to 80 carbon atoms and 0 to 30 heteroatoms (ii) a moiety —Z—R4 wherein R4 is an alicyclic moiety with a main chain of 5 to 80 carbon atoms and 0 to 30 heteroatoms and Z is an aliphatic bridge of 1 to 3 carbon atoms and 0 to 2 heteroatoms, (iii) an aliphatic moiety with a main chain of 3 to 80 carbon atoms and 0 to about 30, and a C≡C group or an azido group. |
| US08716419B2 |
Fluorinated elastic copolymer and production process
To provide a fluorinated elastic copolymer having high crosslinkability, having high flowability and excellent in the compression set and the resistance to bases, and its production process.A process for producing a fluorinated elastic copolymer, which comprises copolymerizing (a) tetrafluoroethylene and (b) propylene and as the case requires, (c) a perfluoro(alkyl vinyl ether) in the presence of an iodine compound represented by the formula RI2 (wherein R is a hydrocarbon group or perfluoroalkyl group having at least 3 carbon atoms) at a temperature of from 0° C. to 50° C., and a fluorinated elastic copolymer obtained by the production process. |
| US08716417B2 |
Olefin polymerization catalyst and preparation method and use thereof
An olefin polymerization catalyst and preparation method and use thereof are provided. The components of the catalyst comprise an active magnesium halide, a titanium compound containing at least one Ti-halide bond loaded on the active magnesium halide, and an internal electron donor selected from one or more silicon esters compounds having formula (I). The method for preparing the catalyst components is that: adding spherical magnesium chloride alcoholate particles and the electron donor into the solution of titanium compound in sequence, and processing with the titanium compound for one or more times to obtain the catalyst. The catalyst system used for the olefin polymerization comprises the catalyst components, a cocatalyst and an external electron donor. The catalyst has high activity for the propylene polymerization, and the activity is 4399 gPP/gTi·h(50° C., 1 h, slurry polymerization at atmospheric pressure), and the isotacticity of the polymer is 98%. |
| US08716414B2 |
Mixed metallocene catalyst composition and method for preparing polyolefin using the same
The present invention relates to a mixed metallocene catalyst composition including a first metallocene catalyst and a second metallocene catalyst, and a method for preparing a polyolefin using the catalyst composition. According to the catalyst composition and the preparation method, provided is a polyolefin having a wide molecular weight distribution and superior mechanical properties and processability. |
| US08716413B2 |
Photocurable composition
A method for the preparation of a photocurable resin by a reaction comprising the following steps i) reacting a mixture of a novolak type epoxy resin (A) and a dicyclopentadiene-phenol glycidylether resin (B) with ii) an advancement component (C) containing at least 2 phenolic hydroxyl groups per molecule; iii) reacting with an unsaturated monocarboxylic acid (D); and iv) esterification of the unsaturated group containing resin obtained from the steps of i) to iii) with a polycarboxylic acid anhydride or a carboxylic acid anhydride (E) is disclosed. |
| US08716409B2 |
Carboxylate terminated polymers and their use in impact-modified plastics
A composition includes a baleable polymer resulting from the polymerization of at least one conjugated diene in the presence of an anionic initiator. The baleable polymer has carboxylate termination resulting from the addition of carbon dioxide to terminate the polymerization reaction. The polymer has Mooney ML1+4 viscosity of >35 and a solution viscosity of X, where X is >75 cP. The addition of an lonolizer to a composition that includes the polymer reduces the solution viscosity of the polymer from X to Y where Y meets the following formula: 0.4X≦Y≧0.58X. The baleable polymer is blended with impact-modified plastics resulting in improved izod values and optical qualities. Processes for making and utilizing the polymer composition, and ionolizer are also described. |
| US08716401B2 |
Semiconductor chip laminate and adhesive composition for semiconductor chip lamination
A semiconductor chip laminate comprises a plurality of semiconductor chips and an adhesive layer through which the plurality of semiconductor chips are laminated, wherein the adhesive layer is composed of an adhesive composition comprising an acrylic polymer (A); an epoxy resin (B); a thermal curing agent (C); and a certain organophosphonium compound (D) as a thermal curing accelerator, and the content of the organophosphonium compound (D) relative to 100 parts by weight in total of the epoxy resin (B) and the thermal curing agent (C) is 0.001 to 15 parts by weight. |
| US08716398B2 |
Method for preparing biodegradable polymer stereocomplexes using a supercritical fluid-organic solvent system and stereocomplexes prepared by the same
The present invention relates to methods for preparing biodegradable polymer stereocomplexes using a supercritical fluid-organic solvent system and polymer stereocomplexes prepared by such methods. The method of the present invention involves introducing two types of homopolymers having different stereostructures and a small amount of organic solvent into a reactor, adding a supercritical fluid thereto, followed by applying a specific temperature and pressure to form a polymer stereocomplex having a crystalline structure. According to the method of the present invention, biodegradable polymer stereocomplexes in the form of powder or porous foam having excellent thermal and mechanical stabilities can be prepared in a simple, economical and environmentally-friendly manner in a single process. |
| US08716397B2 |
Bio-based roofing adhesive compositions
An adhesive composition for use in adhering insulation panels to roofing substrates and roofing membranes to the insulation panels include two components that are mixed prior to application on the roofing substrate. The first component may include a renewable polyol and catalyst. The renewable polyol is selected from any non-petroleum based polyol that is derived from a renewable source. The second component includes isocyanate, and may also include a polyol and a catalyst. The isocyanate and the polyol may each be any non-petroleum based isocyanate or polyol that is derived from a renewable source. |
| US08716394B2 |
Polypropylene compositions containing fillers and/or pigments
Polypropylene compositions having a MFR value (2.16 kg, 230° C.) from 15 to 200 g/10 min., comprising: A) a propylene polymer or polymer composition selected from propylene homopolymers or copolymers of propylene containing up to 5% by moles of comonomer(s), said homopolymers and copolymers having values of MFR, obtained without degradation treatments, from 500 to 2500 g/10 min., or combinations of the said homopolymers or copolymers; B) a filler or pigment, or their combinations; and optionally C) from 0.5 to 5% by weight, with respect to the total weight of A), B) and C), of a compatibilizer. |
| US08716390B2 |
Pigment preparations comprising nonionic surface-active additives
The present invention relates to a solid pigment preparation comprising, each percentage being based on the total weight of the preparation, (A) at least 60% by weight of a pigment component comprising one or more pigments and optionally a filler; (B) 1% by weight to 39% by weight of at least one nonionic water-soluble surface-active additive based on polyethers having an HLB value of greater than 10, (C) 1% by weight to 39% by weight of at least one nonionic surface-active additive based on polyethers having an HLB value of less than 10; (D) 0% by weight to 10% by weight of an additive component comprising at least one further additive, the sum total of the weight fractions not exceeding 100% by weight. The present invention further relates to processes for production thereof and to processes for coloring macromolecular materials. |
| US08716387B2 |
Heterophasic polypropylene copolymer composition
Heterophasic polypropylene composition comprising (A) 45 to 70 wt % of a propylene homo- or copolymer matrix with an MFR2 in accordance with ISO 1133 (230° C., 2.16 kg load) of ≧80 g/10 min and (B) 25 to 40 wt % of an elastomeric propylene-ethylene copolymer, having an intrinsic viscosity IV (ISO 1628, with decalin as solvent) of ≧3.3 dl/g and an ethylene content of 20 to 50 wt %, (C) 0-15 wt % of an elastomeric ethylene/alpha-olefin random copolymer (D) 3-25 parts per weight of inorganic filler, the heterophasic polypropylene compositions having a total MFR2 (230° C./2.16 kg) in accordance with ISO 1133 of ≧5 g/10 min, a Charpy notched impact strength according to ISO 179/1eA at +23° C. of ≧15.0 kJ/m2, preferably ≧25.0 kJ/m2, a minimum value for the Charpy notched impact strength according to ISO 179/1eA at −20° C. of ≧7.0 kJ/m2, preferably ≧10.0 kJ/m2 and a tensile modulus according to ISO 527-3 of ≧1200 MPa; their preparation and use for producing injection moulded articles being free of flow marks. |
| US08716386B2 |
Method for producing polymeric balls or beads containing metal elements
A method for producing polymeric balls or polymeric beads doped with at least one metal element is provided. The method may comprise the following steps: a) a step for forming polymeric balls or beads by polymerization, in an organic phase comprising a polymerization initiator, of at least one ethylenic monomer comprising at least one chelating ligand of at least one metal element; and b) a step for putting said polymeric balls or beads in contact with a solution comprising at least one metal element. |
| US08716380B2 |
Polycarbonate composition having improved heat stability
The invention relates to a polycarbonate composition having reduced subsequent yellowing of the mouldings produced therefrom on heat ageing and having good optical properties of the polycarbonate composition on processing. |
| US08716375B2 |
Organosilicon compound as well as rubber composition, tire primer composition, paint composition and adhesive using the same
This invention relates to an organosilicon compound having a cyclic structure with nitrogen atom and silicon atom, and one or more sulfur atoms in its molecule, and having a bonding side of one or more groups having as small steric hindrance to silicon atom, a rubber composition formed by compounding an inorganic filler (B) and the organosilicon compound (C) into a rubber component (A) consisting of natural rubber and/or diene-based synthetic rubber, and a tire using such a rubber composition. |
| US08716373B2 |
Biodegradable resin composition
A biodegradable resin composition containing a biodegradable resin and a cellulose having a crystallinity of X (%), wherein the cellulose is obtained by a step including subjecting a cellulose-containing raw material to a pulverization treatment (A), wherein the cellulose-containing raw material contains a cellulose having a crystallinity of Y (%), and has a bulk density of from 100 to 500 kg/m3, and an average particle size of from 0.01 to 1.0 mm, and contains a cellulose in an amount of 20% by weight or more of a residue component obtained by removing water from the raw material, wherein X and Y satisfy the following formulas: 50≦X≦Y−5 (1) and 55≦Y≦99 (2). The biodegradable resin composition can be suitably used for various industrial applications, such as daily sundries, household electric appliance parts, and automobile parts. |
| US08716370B2 |
Roof sloping compound
A roof sloping compound for creating an auxiliary slope over a wide variety of roof membranes and substrates. The compound includes a dry mixture of aggregate, cement and a redispersible dry polymer adapted to be mixed with water to define a substantially self-leveling consistency enabling the compound to be readily screeded into place in a desired thickness. The aggregate comprises dolomite or limestone and the redispersible dry polymer can comprise a binder based on a copolymer of ethylene vinyl acetate. In a lightweight embodiment of the compound, the aggregate includes lightweight fillers comprising perlite and low density glass granules and a superplasticizer is added to the dry mixture to reduce water demand. |
| US08716369B2 |
Reinforced composite material, method of preparing the same, its use for preparing manufactured products, as well as manufactured products formed in this way and their use
A reinforced composite material based on aluminous cement and tabular alumina or corundum, reinforced with glass-fibres, method of preparing the same, its use for preparing manufactured products, as well as manufactured products formed in this way and their use. |
| US08716368B2 |
Unsaturated polyester resin or vinyl ester resin composition
This invention relates to unsaturated polyester resin or vinyl ester resin compositions comprising a polymer containing reactive unsaturations as a resin; a 1,3-dioxo-component, and optionally a reactive diluent and/or an inhibitor and/or a stabilizer; the resin compositions being curable with a peroxide component, and wherein the resin in the resin composition has an acid value=10; and the resin composition contains—while being cured—a base, which is either selected from the group of organic or inorganic oxides, hydroxides, alkoxides or carboxylates for each of which the cation has a redox potential of the metal of at most −1V, or of ammonium ions; or is selected from the group of nitrogen-containing organic compounds. The present invention also relates to objects and structural parts prepared from such resin composition by curing with a peroxide. Finally the invention also relates to methods of peroxide curing of unsaturated polyester or vinyl ester curing and its use in chemical anchoring, roof coatings etc. |
| US08716361B2 |
Curable fluorine-containing resin and active-energy-ray-curable composition including the same
Provided is a curable fluorine-containing resin produced by causing a reaction between a polymer (P) and a compound (C); the polymer (P) being prepared by copolymerization in which essential monomer components are a compound (A) having a poly(perfluoroalkylene ether) chain and styryl groups at both ends of the poly(perfluoroalkylene ether) chain and a polymerizable unsaturated monomer (B) having at least one functional group (b) selected from the group consisting of a hydroxy group, an isocyanate group, an epoxy group, a carboxyl group, an acid anhydride group, and a carboxylic acid halide group; the compound (C) having a polymerizable unsaturated group and at least one functional group (c) that has reactivity with the functional group (b) and is selected from the group consisting of a hydroxy group, an isocyanate group, an epoxy group, a carboxyl group, an acid anhydride group, and a carboxylic acid halide group. |
| US08716358B2 |
Anion exchange membrane and method for producing same
There is provided an anion exchange membrane comprising, as a main element, a block copolymer having a vinyl alcohol polymer block and a cationic-group containing polymer block as components and which is subjected to a crosslinking treatment. An anion exchange membrane is produced by heating a film obtained from a solution of the block copolymer at a temperature of 100° C. or more, crosslinking the film with a dialdehyde compound in water, an alcohol or a mixture of these under an acidic condition and then washing the film with water. Thus, there can be provided an anion exchange membrane in which organic fouling can be prevented and which exhibiting excellent basic properties such as a membrane resistance and an ionic transport number and excellent membrane strength. |
| US08716357B2 |
Hydrophilic polymer membranes
A hydrophilic polymeric ionomer obtainable by reacting, in a solvent, components comprising a polymer and an ionic component selected from a strong acid or a strong base. The present invention also comprises methods of forming such membranes. |
| US08716345B2 |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids. |
| US08716343B2 |
Calixarene-based peptide conformation mimetics, methods of use, and methods of making
A class of topomimetic calixarene-based peptide mimetics is described. Calixarene-based peptide mimetics have various biological activities such as, for example, bactericidal activity, antiangiogenic activity, and/or antitumor activity. Methods of use and methods of designing calixarene-based peptide mimetics are described. |
| US08716341B2 |
Topically applicable compositions for the treatment of keratinization disorders
Topical compositions containing from 0.01% to 0.09% by weight of adapalene or salts thereof are useful for the treatment or prevention of keratinization disorders, particularly acne, and additionally contain at least one gelling agent selected from among carbomers, polysaccharides, cellulose and its derivatives, copolymers of acrylate and of alkyl acrylate, copolymers of acrylamide and of sodium acrylamido-2-methylpropanesulfonate, and xanthan gum. |
| US08716340B2 |
Topical composition
The invention relates to beneficial topical pharmaceutical compositions comprising the diclofenac sodium salt in unusually low amounts. The compositions represent opaque emulsion-gels, in which diclofenac is kept fully dissolved. |
| US08716332B2 |
Supplement composition and method of use to treat anhidrosis
The present invention relates to a dietary supplement composition made of: linolenic expeller pressed soybean oil in the range of 65%-85%, Omega 3 (18/12) fish oil 15%-35%, and 1%-20% alpha-tocopherol and a method to use this composition to supplement the diet of a domestic animal, such as a canine or an equine. |
| US08716331B2 |
Supplement composition and methods of use
The present invention relates to a dietary supplement composition made of: linolenic expeller pressed soybean oil in the range of 65%-85%, Omega 3 (18/12) fish oil 15%-35%, and 1%-20% alpha-tocopherol and a method to use this composition to supplement the diet of a domestic animal, such as a canine or an equine. |
| US08716330B2 |
Supplement composition and method of use
The present invention relates to a dietary supplement composition made of: linolenic expeller pressed soybean oil in the range of 65%-85%, Omega 3 (18/12) fish oil 15%-35%, and 1%-20% alpha-tocopherol and a method to use this composition to supplement the diet of a domestic animal, such as a canine or an equine. |
| US08716329B2 |
Use of parthenolide derivatives as antileukemic and cytotoxic agents
The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 membered ring, said ring optionally comprising 1 or more heteroatoms or a group selected from —CO—, —SO—, —SO2— and —PO—; or a pharmaceutically acceptable salt, ester or prodrug thereof. |
| US08716328B2 |
Acid-labile lipophilic prodrugs of cancer chemotherapeutic agents
The present application discloses an acid labile lipophilic molecular conjugate of cancer chemotherapeutic agents and methods for reducing or substantially eliminating the side effects of chemotherapy associated with the administration of a cancer chemotherapeutic agent to a patient in need thereof. |
| US08716327B2 |
Methods of treating fatty liver disease
The disclosure provides methods for treating fatty liver disease and associated conditions by inhibiting the synthesis of glucosphingolipids, as exemplified by the use of glucosylceramide synthase substrate analogs. |
| US08716319B2 |
Substituted heterocyclic compounds
The present invention relates to novel heterocyclic compounds and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula (I): wherein Q1, Q2, R2, R3, R4, R5, and R6 are as described herein. The invention also relates to methods for the preparation of the compounds, and to pharmaceutical compositions containing such compounds. |
| US08716318B2 |
Pyridone sulfonamides and pyridone sulfamides as MEK inhibitors
This invention concerns N-(ortho phenylamino dihydropyridyl)sulfonamides and N-(ortho phenylamino dihydropyridyl), N′-alkyl sulfamides which are inhibitors of MEK and are useful in the treatment of cancer and other hyperproliferative diseases. |
| US08716314B2 |
Isotopologues of thalidomide
Provided herein are thalidomide, which is enriched with isotopes such as deuterium. Pharmaceutical compositions comprising the isotopes-enriched compounds, and methods of using such compounds are also provided. |
| US08716312B2 |
Inhibitors of diacylglycerol acyltransferase
The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below: |
| US08716309B2 |
Pharmaceutical composition comprising pyridone derivatives
A pyridone derivative compound and a pharmaceutically acceptable salt, isomer, solvate or hydrate thereof, and a preventive or therapeutic pharmaceutical composition for cognitive disorders that includes the pyridone derivative compound or a pharmaceutically acceptable salt, isomer, solvate or hydrate thereof. |
| US08716308B2 |
(1-azinone)-substituted pyridoindoles
Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF3, and —CN; G is —CR12R13—NR5— or —NR5—CR12R13; R5; is H, optionally substituted alkyl, optionally substituted heterocycle, —C(═O)—R6, —C(═O)—O—R7, or —C(═O)—NR19R20; R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle; R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H or optionally substituted alkyl; R14 and R15 are each independently H or halogen; L is —CH2—O—, —CH2CH2—, —CH═CH— or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine. |
| US08716307B2 |
Combination antineoplastic therapy
The present invention is directed to methods of using a sirolimus drug and chloroquine or a quinoline derivative in combination. Methods of use are also described. |
| US08716306B2 |
Carboxamide bioisosteres of opiates
A compound of formula I is disclosed. Compounds of formula I are useful as analgesics, anti-inflammatory agents, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. |
| US08716305B2 |
Multicomponent crystalline system of rosuvastatin calcium salt and vanillin
A novel solid form of Rosuvastatin comprises as the active ingredient a salt of bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)-amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid] and vanillin or vanillin derivatives. The crystal comprising the two components, and minor amounts of water, shows improved properties such as crystallization behavior stability and decreased hydroscopic behavior. |
| US08716304B2 |
Preparation method of MLN4924 as an E1 activating inhibitor
The present invention relates to a method for preparation of MLN4924 as an E1 activating inhibitor, and more specifically, to a method for efficient and stereoselective preparation of MLN4924 by means of key steps involving stereoselective reduction of cyclopentenone with isopropylidene, regioselective cleavage of isopropylidene moiety, and synthesis of cyclic sulfate. |
| US08716300B2 |
Frequency modulated drug delivery (FMDD)
Embodiments of the present disclosure include a coordination complex, comprising a first biologically active moiety, a second biologically active moiety, and a metal, wherein the first biologically active moiety and second biologically active moiety are bound to the metal by covalent coordination bonds, and wherein the first biologically active moiety and second biologically active moiety are different. These complexes may enhance the pharmacodynamic properties of biologically active moieties. |
| US08716298B2 |
Composition for reducing skin wrinkles including PDE5 inhibitor
Disclosed is a composition effective in reducing skin wrinkles. The composition comprises or uses a phosphodiesterase 5 (PDE5) inhibitor as an active ingredient. Further disclosed is a method for reducing skin wrinkles using the composition. |
| US08716293B2 |
Macrocyclic integrase inhibitors
Compound having formula I and pharmaceutically acceptable salts or solvates thereof, their pharmaceutical formulations and use as HIV inhibitors. |
| US08716291B2 |
Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
Provided are compounds of Formula I and compounds of Formula II: and pharmaceutically acceptable salts thereof, and methods for their use. |
| US08716289B2 |
Carbamate derivatives of alkyl-heterocycles, preparation thereof and therapeutic use thereof
Compound corresponding to general formula (I): in which R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy or NR8R9 group; n is an integer equal to 1, 2 or 3 and m is an integer equal to 1 or 2; A is a covalent bond or a C1-8-alkylene group; R1 is a phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, naphthyl, quinolinyl, isoquinolinyl, phthalazinyl, quinazolinyl, quinoxalinyl, cinnolinyl or naphthyridinyl group, this group being optionally substituted; R3 is a hydrogen or fluorine atom, a C1-6-alkyl group or a tritluoromethyl group; R4 is a group selected from furanyl, pyrrolyl, thienyl, isothiazolyl, oxazolyl, isoxazolyl, pyrazolyl, oxadiazolyl, thiadiazolyl, imidazole, triazolyl, tetrazolyl, oxazolone, oxazolidinone, isoxazolone, isoxazolidinone, isothiazolone, isothiazolidinone, imidazolone, imidazolidinone, pyrazolone, pyrazolidinone, oxadiazolone, thiadiazolone and triazolone, this group being optionally substituted; in the form of a base or of an addition salt with an acid. Therapeutic use. |
| US08716284B2 |
Adamantyl diamide derivatives and uses of same
The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same. |
| US08716283B2 |
Type III secretion inhibitors, analogs and uses thereof
The invention, in some aspects, relates to compounds and compositions useful for inhibiting Type III secretion systems in pathogenic bacteria, such as Yersinia Pestis. In some aspects, the invention relates to methods for discovering inhibitors of the Type III secretion system and uses of such inhibitors in the treatment and prevention of disease. |
| US08716278B1 |
Abuse deterrent and anti-dose dumping pharmaceutical salts useful for the treatment of attention deficit/hyperactivity disorder
A pharmaceutical composition comprising a drug substance consisting essentially of a pharmaceutically acceptable organic acid addition salt of an amine containing pharmaceutically active compound wherein the amine containing pharmaceutical active compound is selected from the group consisting of racemic or single isomer ritalinic acid or phenethylamine derivatives and the drug substance has a physical form selected from amorphous and polymorphic. |
| US08716275B2 |
Compound for the treatment of hepatitis C
The present invention provides (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1 -methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl) carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide (formula I), including pharmaceutically acceptable salts, as well as compositions and methods of using the compound. The compound has activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV. |
| US08716274B2 |
Heteroaryl pyridone and aza-pyridone compounds
Heteroaryl pyridone and aza-pyridone compounds of Formula I are provided, where one or two of X1, X2, and X3 are N, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. |
| US08716273B2 |
N-(amino-heteroaryl)-1H-pyrrolopyridine-2-carboxamides derivatives preparation thereof and their use in therapy
The invention relates to compounds of the general formula (I): Wherein X, Y, Z, Z1, Z2, Z3, Z4 and n are as defined herein. The invention also relates to a method for making the same and to the use thereof in therapy. |
| US08716272B2 |
N-(amino-heteroaryI)-1H-pyrrolopyridine-2-carboxamides derivatives preparation thereof and their use in therapy
The invention relates to compounds of the general formula (I): Wherein X, Y, Z, Z1, Z2, Z3, Z4 and n are as defined herein. The invention also relates to a method for making the same and to the use thereof in therapy. |
| US08716269B2 |
Combination of pilocarpin and methimazol for treating Charcot-Marietooth disease and related disorders
The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related peripheral neuropathies. More particularly, the invention relates to combined therapies for treating said disease by affecting simultaneously muscarinic receptor signaling and thyroid hormone pathway in a subject. |
| US08716268B2 |
Nitrate esters of corticoid compounds useful as diuretics
The present invention relates to the diuretic effects of nitrate esters of corticoid compounds. A patient in heart failure may be treated by administering a therapeutically effective dosage of a pharmaceutical composition comprising a nitrate ester of corticoid compound as a diuretic having the general formula B—X1—NO2. A method of improving kidney function by administering a therapeutically effective dosage of a pharmaceutical composition having a nitrate ester of corticoid compound of the same formula is also described. |
| US08716267B2 |
Bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators
The present invention relates to novel bicyclic methyl amine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors. |
| US08716266B2 |
Use of PKC-iota inhibitors for the treatment of glioma
The present invention pertains to use of PKC-iota inhibitors for treatment of glioma. In a specific embodiment, the treatment method comprises administering ICA-1 or a salt thereof to a subject with glioma. In another embodiment, the treatment method comprises contacting glioma cells with an effective amount of ICA-1 or a salt thereof. |
| US08716265B2 |
4-quinolinemethanols as anti-malarial agents
The present invention relates to substituted 4-qinolinemethanols and pharmaceutical compositions thereof and methods of using the same for treating of malaria, tuberculosis, and other infectious diseases. |
| US08716263B2 |
Synthesis of purine nucleosides
A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof. |
| US08716262B2 |
Nucleoside phosphoramidates
A nucleoside compound having activity against hepatitis C virus is disclosed. |
| US08716261B2 |
Maintenance of platelet inhibition during antiplatelet therapy
A method for reducing or maintaining platelet inhibition in a patient by administering cangrelor prior to an invasive procedure is described. The method of this invention can be used for patients in need of antiplatelet therapy or at risk of thrombosis. The method can further be used in patients who were previously treated with long-acting platelet inhibitors without increasing the risk of excessive bleeding. |
| US08716258B2 |
Regulation of metabolism by miR-378
The present invention provides a method of regulating fatty acid metabolism in a cell by contacting the cell with a modulator of miR-378 and/or miR-378* activity or expression. The present invention also provides a method of treating or preventing a metabolic disorder, such as obesity, diabetes, or metabolic syndrome, in a subject by administering to the subject an inhibitor of miR-378 and/or miR-378* expression or activity. Methods of treating or preventing pathologic cardiac hypertrophy, cardiac remodeling, myocardial infarction, or heart failure in a subject by inhibiting the expression or activity of miR-378 and/or miR-378* in a subject are also disclosed. |
| US08716256B2 |
Method of therapy and diagnosis of atherosclerosis
There is provided a method of therapy of atherosclerosis, by providing microRNA let-7g, an analogue thereof or modified let-7g to organisms to inhibit the expression of lectin-like oxidized low density lipoprotein receptor-1 (LOX-1), and the binding of LOX-1 and oxidized low-density lipoprotein (oxLDL), so as to block the pathogenesis of atherosclerosis. Also, a method of diagnosis of atherosclerosis comprises determining the levels of microRNA let-7g in serum or plasma samples of organisms, in which the levels of microRNA let-7g is estimated in individuals with atherosclerosis as compared to individuals without atherosclerosis. |
| US08716254B2 |
DNA vaccines against tumor growth and methods of use thereof
A DNA vaccine suitable for eliciting an immune response against cancer cells comprises a DNA construct operably encoding a cancer-associated Inhibitor of Apoptosis-family protein and an immunoactive gene product, such as a cytokine or a ligand for a natural killer cell surface receptor, in a pharmaceutically acceptable carrier. A preferred cytokine is CCL21. Preferred ligands for a natural killer cell surface receptor include human MICA, human MICB, human ULBP1, human ULBP2, and human ULBP3. The cancer-associated Inhibitor of Apoptosis (IAP)-family protein is preferably a survivin protein or livin protein. Method of inhibiting tumor growth by administering the vaccine of the invention to a mammal is also described. |
| US08716250B2 |
Diazoxide for the treatment of Friedreich's ataxia
A pharmaceutical preparation treats Friedreich's ataxia and treats or prevents pathologies related thereto. In particular, the pharaceutical preparation concerns the use of diazoxide or 7-chloro-3-methyl-4H-1,2,4 benzothiadiazine 1,1-dioxide, in combination with glucose and/or leucine, for the treatment of Friedreich's ataxia (FRDA) and for the treatment or prevention of pathologies related thereto. |
| US08716248B2 |
Lipid tripeptide-based hydrogelator and hydrogel
A hydrogel that includes an aqueous solution or an alcohol aqueous solution, and a hydrogelator containing a lipid peptide represented by Formula (1), or a pharmaceutically usable salt thereof. In Formula (1), R1 represents an aliphatic group having 9 to 21 carbon atoms; R2, R3, and R4 independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms that optionally has a branched chain having 1 or 2 carbon atoms, a phenylmethyl group, or a —(CH2)n—X group, and at least one of R2, R3, and R4 represents a —(CH2)n—X group; n represents an integer from 1 to 4; and X represents an amino group, a guanidino group, a —CONH2 group, or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring that optionally has 1 to 3 nitrogen atoms. |
| US08716243B2 |
Methods of effecting Wnt signaling through Dkk structural analysis
Compositions and methods related to Wnt signaling regulation by Dickkopf (Dkk) polypeptides and Wnt-related diseases are disclosed. For example, compounds that bind a Dkk or LRP polypeptide are disclosed. Compounds that disrupt binding of a Dkk polypeptide to an LRP polypeptide are also disclosed. Methods for using the described compounds and compositions are also disclosed. |
| US08716237B2 |
Methods for the treatment or prevention of hemorrhagic conditions
The present invention relates to a method for treatment or prevention of a hemorrhagic condition in a patient by administering plasminogen activator inhibitor-1 (“PAI-1”) and/or an inhibitor of deubiquitinating enzyme CYLD (“CYLD”) to a patient. Pharmaceutical compositions that include one or both of PAI-1 and an inhibitor of CYLD are also disclosed. |
| US08716233B2 |
NOTCH mutations leading to increased receptor signaling
The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increase receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients. |
| US08716229B2 |
Osteoprotegerin in neuroprotection
Methods for treating neurodegeneration, e.g., sensorineural hearing loss, or a demyelinating disease, using bisphosphonates, ERK kinase inhibitors, and osteoprotegerin (OPG) proteins or nucleic acids. |
| US08716227B2 |
Graft prosthesis, materials and methods
A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient. |
| US08716222B2 |
Methods and compositions for promoting organ development
Compositions and methods are provided for promoting organ development in warm blooded animals, and in particular in certain aspects a premature infant or fetus. Compositions and methods are also provided for the administration of at least one colony stimulating factor-1 protein (CSF-1), precursor, variant, analogue, derivative thereof, or combinations thereof, or otherwise, at least one nucleic acid molecule encoding colony stimulating factor-1 protein (CSF-1), precursor, variant, analogue, derivative thereof, or combinations thereof. |
| US08716221B2 |
Modified exendins and uses thereof
The present invention discloses a modified exendin or pharmaceutically acceptable salts thereof, wherein the modified exendin comprises an amino acid sequence having at least 90% sequence identity to SEQ ID No. 17 and the amino acid sequence has a higher stability than the non-modified exendin of SEQ ID No. 4. These compounds are useful in treating type 2 diabetes as GLP-1 receptor agonists. |
| US08716220B2 |
Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amyloid beta
The present disclosure provides compositions containing a leptin product and methods of clinical therapy and diagnostic methods for progressive cognitive disorders. According to one aspect, the described invention provides a method for treating a progressive cognitive disorder. According to another aspect, the described invention provides a method for improving resilience of cognitive function in a subject in need thereof. According to another aspect, the described invention provides a method for identifying an effective therapeutic agent for treating a progressive cognitive dysfunction disease or disorder that results from at least one of accumulation of Aβ, hyperphosphorylation of tau, or accumulation of neurofibrillary tangles. |
| US08716219B2 |
Crosslinked protein nanocrystals, crosslinked protein nanoaggregates and method of preparation thereof
This invention relates to crosslinked protein nanoparticles and a method for producing the same. The method comprises the preparation and nanonization (i.e., size reduction to the nanoscale) of protein nanoparticle precursor materials—i.e., crosslinked proteins of the micron or greater size—via mechanical or hydrodynamic shear, mechanical crushing, sonic cavitation and/or hydrodynamic cavitation. |
| US08716213B2 |
Liquid detergent composition comprising an external structuring system comprising a bacterial cellulose network
A structured liquid detergent composition in the form of a liquid matrix made up of an external structuring system of a bacterial cellulose network; water; and surfactant system including an anionic surfactant; a nonionic surfactant; a cationic surfactant; an ampholytic surfactant; a zwitterionic surfactant; or mixtures thereof, wherein said liquid matrix has a yield stress of from about 0.003 Pa to about 5.0 Pa at about 25° C. and provides suitable particle suspension capabilities and shear thinning characteristics. |
| US08716211B2 |
Detergent composition
The invention provides a solid dishwashing detergent composition comprising an amount of from 0.01 to 10 % wt of one or more anionic polyesters. The compositions exhibit good drying properties, especially on plasticware. |
| US08716202B2 |
Method for improving fluorocarbon elastomer seal compatibility
Disclosed is a method for improving compatibility of a fluorocarbon elastomer seal with a lubricating oil composition containing (a) a major amount of a base oil of lubricating viscosity; and (b) one or more dispersants containing one or more basic nitrogen atoms. The method involves adding to the lubricating oil composition an effective amount of one or more fluorocarbon elastomer compatibility improving agents comprising one or more non-halogen-containing oil-soluble titanium complexes comprising at least one ligand selected from the group consisting of (i) an anion of a saturated carboxylic acid, (ii) an anion of an α-, β- or γ-hydroxycarbonyl compound; (iii) an anion of an α-, β- or γ-hydroxycarboxylic acid, amide, or ester; (iv) an anion of an α-, β- or γ-aminocarboxylic acid; and (v) an anion of an α-, β- or γ-keto acid. |
| US08716201B2 |
Alkylated naphtylene base stock lubricant formulations
In one embodiment a novel lubricant is disclosed. The lubricant comprises an alkylated naphthalene base stock with a viscosity of at least 2 cSt and less than 22 cSt kv100° C., the alkylated naphthalene base stock is greater than 55 weight percent of the lubricant, a PAO base stock with at least 4 cSt and less than 250 cSt kv100° C., the PAO base stock is at least 2 and less than 40 weight percent of the lubricant, at least 0.5 and less than 1.5 weight percent of the lubricant is an amine antioxidant additive, at least 0.5 and less than 1.5 weight percent of the lubricant is a defoamant additive, at least 0.1 and less than 0.4 weight percent of the lubricant is an alkylated rust inhibitor additive, and the lubricant has a viscosity of at least 4 cSt and less than 10 cSt kv100° C., less than 10 ppm metals, less than 100 ppm sulfur, and a VI greater than 70. |
| US08716199B2 |
Corrosion inhibitor intensifier compositions
Corrosion inhibitor compounds including a corrosion inhibitor and a corrosion inhibitor intensifier composition comprising an intensifier compound that corresponds to the following formula: wherein R1 is a methyl or ethyl group, and R2 is H or an alkyl, aryl, alkyl aryl, alkylthio aryl, alkyloxy aryl, halogenated aryl, phenyl, alkyl phenyl, alkylthio phenyl, alkyloxyphenyl, or a halogenated phenyl group. |
| US08716197B2 |
Lubricating compositions for use with downhole fluids
Adding a lubricant having a metal stearate and polytetrafluoroethylene (PTFE) to a downhole fluid may lubricate a first surface once the downhole fluid has been circulated within a subterranean reservoir wellbore. Friction, torque, and/or drag may be reduced when the lubricated first surface contacts a second surface. The first surface may be or include, but is not limited to a wellbore casing, a drill string, a pipe, a formation, a drill bit, a metal surface within a mud motor, formation evaluation tool, at least one drilling tool, and combinations thereof. One or both of the first and second surfaces may be metal. The downhole fluid may be or include, but is not limited to, a drilling fluid, a completion fluid, a fracturing fluid, a drill-in fluid, a workover fluid, and combinations thereof. |
| US08716196B2 |
Synthetic polypeptide libraries and methods for generating naturally diversified polypeptide variants
The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence. |
| US08716195B2 |
Antibody ultrahumanization by predicted mature CDR blasting and cohort library generation and screening
Methods and compositions directed to improved universal antibody libraries that rationally exploit human diversity information contained within reference antibody libraries, such as universal antibody libraries, are disclosed. The disclosed processes involve use of a query CDR sequence to guide incorporation of human antibody diversity present within the reference library into cohort libraries of the invention. Methods for making and screening such cohort libraries for isolating therapeutics suitable for treating disease are also disclosed. |
| US08716192B2 |
Micro RNAs for identification of exposure to lower aliphatic saturated aldehydes and the method of identification using thereof
The present invention relates to a biomarker for the identification of exposure to lower aliphatic saturated aldehydes by using micro RNA and a method for the identification of exposure to lower aliphatic saturated aldehydes using the same. In this invention, the micro RNA at least 1.5 fold up-regulated by exposure to lower aliphatic saturated aldehydes and the micro RNA up to 0.66 fold down-regulated by the same were selected. These two micro RNAs can be effectively used as the biomarker for the monitoring of lower aliphatic saturated aldehydes and for the risk assessment thereby and at the same time as a tool to investigate the mechanism of toxicity caused by such lower aliphatic saturated aldehydes. |
| US08716191B2 |
Method of preparing an adduct
A method for identifying one or several molecular structure(s) having a high-affinity for a target of interest, the molecular structure(s) each including one nucleotide chain onto which is hybridized at least one PNA-encoded molecule. |
| US08716190B2 |
Amplification and analysis of selected targets on solid supports
Methods are provided for multiplexed amplification of selected targets and analysis of the amplified targets. In preferred aspects the amplification and analysis take place on the same solid support and preferably in a localized area such as a bead or a feature of an array. Targets are circularized by hybridization to probes followed by ligation of the ends of the target to form a closed circle. The targets are then used as template for extension of an array bound probe resulting in extended probes having multiple copies of the target. The extended probes can then be analyzed. The methods may be used for genotyping, sequencing and analysis of copy number. |
| US08716177B2 |
Production process of sulfide containing nickel and cobalt
A production process of a sulfide containing nickel and cobalt by adding a sulfurizing agent under pressurization into an aqueous solution of sulfuric acid containing nickel and cobalt, which is capable of recovering nickel and cobalt as a sulfide in high yield, as well as enhancing the utilization efficiency of hydrogen sulfide gas.A production process of a sulfide containing nickel and cobalt by adding a sulfurizing agent under pressurization into an aqueous solution of sulfuric acid containing nickel and cobalt, characterized by supplying, as the above sulfurizing agent, hydrogen sulfide gas into the vapor phase of inside of a reactor, as a major sulfurizing agent, as well as, by supplying an aqueous solution containing a sodium hydrosulfide, which is recovered by absorbing unreacted hydrogen sulfide gas, which is discharged from inside of the reactor in producing the above sulfide, with an aqueous solution of sodium hydroxide, into the liquid phase. |
| US08716175B2 |
Catalyst for producing ethylene oxide, process for producing the catalyst and process for producing ethylene oxide
There is provided a catalyst for producing ethylene oxide from ethylene which is composed of at least silver (Ag), cesium (Cs), rhenium (Re) and a carrier, and can be improved, in particular, in selectivity.The present invention relates to a catalyst for producing ethylene oxide from ethylene, comprising at least silver (Ag), cesium (Cs), rhenium (Re) and a carrier, said catalyst being produced by optionally pretreating the carrier to support an alkali metal thereon and then supporting Ag, Cs and Re on the carrier, wherein the carrier has a specific surface area of 0.6 to 3.0 m2/g and a weight ratio of a silicon (Si) content to a sodium (Na) content of 2 to 50 in terms of SiO2/Na2O; a content of Re in the catalyst is 170 to 600 ppm per 1 m2/g of the specific surface area of the carrier on the basis of a weight of the carrier; and a molar ratio of Cs to Re in the catalyst is 0.3 to 19. |
| US08716174B2 |
Method for producing fine metal hydroxide particles
There is provided a production method in which highly transparent fine metal hydroxide particles having a small particle size and excellent in monodispersibility can be easily produced without requiring grinding. The method for producing fine metal hydroxide particles at least includes: a reaction step of mixing an aqueous solution of a metal salt, for example, a magnesium salt, with an aqueous solution of a hydroxide salt to precipitate metal hydroxide particles in an uncrystallized state; a purification step of removing by-product salt from a mixed solution containing the precipitated metal hydroxide particles in an uncrystallized state; a surface treatment step of treating the metal hydroxide particles in an uncrystallized state obtained through the purification step with a surface-treatment agent on the surface thereof; and a heating step of crystallizing the surface-treated metal hydroxide particles in an uncrystallized state by hydrothermal treatment. |
| US08716171B2 |
Method of manufacturing a porous gallium (III) oxide photocatalyst for preparation of hydrocarbons
The present invention relates to preparation of porous gallium (III) oxide [Ga2O3] photocatalyst for production of hydrocarbons a porous gallium oxide photocatalyst for production of hydrocarbons, manufactured by the foregoing method, and a process of producing hydrocarbons using the porous gallium oxide photocatalyst for production of hydrocarbons, manufactured by the foregoing method. |
| US08716169B2 |
System and method for protection of SCR catalyst and control of multiple emissions
The present invention relates generally to the field of emission control equipment for boilers, heaters, kilns, or other flue gas-, or combustion gas-, generating devices (e.g., those located at power plants, processing plants, etc.) and, in particular to a new and useful method and apparatus for preventing the poisoning and/or contamination of an SCR catalyst. In another embodiment, the method and apparatus of the present invention is designed to protect an SCR catalyst, while simultaneously providing emission control. |
| US08716167B2 |
Catalyst for fuel cell and polymer electrolyte fuel cell using the same
[Problem] To provide a catalyst which has high oxygen reduction activity, also has excellent durability, and is inexpensive and excellent in electric power generation cost as compared with noble metal catalysts such as platinum.[Solution to problem] A catalyst for a polymer electrolyte fuel cell, including a graphitized carbon powder and a niobium oxycarbonitride or a titanium oxycarbonitride as an active substance, and a polymer electrolyte fuel cell using the catalyst. |
| US08716166B2 |
Multifunctional chain shuttling agents
The invention generally relates to chain shuttling agents (CSAs), a process of preparing the CSAs, a composition comprising a CSA and a catalyst, a process of preparing the composition, a processes of preparing polyolefins, end functional polyolefins, and telechelic polyolefins with the composition, and the polyolefins, end functional polyolefins, and telechelic polyolefins prepared by the processes. |
| US08716164B2 |
Hydrodemetallization catalyst and process
This invention is directed to hydrodemetallization catalysts and hydrodemetallization processes employing a magnesium aluminosilicate clay. The magnesium aluminosilicate clay has a characteristic 29Si NMR spectrum. The magnesium aluminosilicate clay is the product of a series of specific reaction steps. Briefly, the magnesium aluminosilicate clay employed in the catalyst and process of the invention is made by combining a silicon component, an aluminum component, and a magnesium component, under aqueous conditions and at an acidic pH, to form a first reaction mixture and subsequently the pH of the first reaction mixture is adjusted to greater than about 7.5 to form a second reaction mixture. The second reaction mixture is allowed to react under conditions sufficient to form the magnesium aluminosilicate clay. The resulting magnesium aluminosilicate clay combines high surface area and activity for use in hydrodemetallization catalysts and processes. |
| US08716163B2 |
Hydrocarbon conversion catalyst
A hydrocarbon conversion catalyst, which comprises, based on the total weight of the catalyst, 1-60 wt % of a zeolite mixture, 5-99 wt % of a thermotolerant inorganic oxide and 0-70 wt % of clay, wherein said zeolite mixture comprises, based on the total weight of said zeolite mixture, 1-75 wt % of a zeolite beta modified with phosphorus and a transition metal M, 25-99 wt % of a zeolite having a MFI structure and 0-74 wt % of a large pore zeolite, wherein the anhydrous chemical formula of the zeolite beta modified with phosphorus and the transition metal M is represented in the mass percent of the oxides as (0-0.3)Na2O.(0.5-10)Al2O3.(1.3-10)P2O5.(0.7-15)MxOy.(64-97)SiO2, in which the transition metal M is one or more selected from the group consisting of Fe, Co, Ni, Cu, Mn, Zn and Sn; x represents the atom number of the transition metal M, and y represents a number needed for satisfying the oxidation state of the transition metal M. |
| US08716161B2 |
Methods of regenerating aromatization catalysts
Methods for treating or rejuvenating a spent catalyst are disclosed. Such methods can employ a step of halogenating the spent catalyst, followed by decoking the halogenated spent catalyst. |
| US08716160B2 |
Method of activating a Fischer-Tropsch catalyst
This invention relates to the field of Fischer-Tropsch catalysis, in particular to activation of a Fischer-Tropsch catalyst. More particularly the invention relates to a method of activating an iron based Fischer-Tropsch catalyst which includes iron in a positive oxidation state by contacting in a reactor said iron based catalyst with a reducing gas selected from the group consisting of CO and a combination of H2 and CO; at a temperature of at least 245° C. and below 280° C.; at a reducing gas pressure of above 0.5 MPa and not more than 2.2 MPa; and at a GHSV of total gas fed to the reactor of at least 6000 ml(N)/g cat/h, thereby reducing the iron that is in a positive oxidation step in the catalyst. |
| US08716157B2 |
Optical glass, glass material for press molding, and optical element
An optical glass in the form of an oxide glass, characterized by comprising, denoted as cation percentages: P5+ 14 to 36%; Bi3+ 12 to 34%; Nb5+ 12 to 34%; Ti4+ 5 to 20%; and W6+ 0 to 22%; wherein the total content of Bi3+, Nb5+, Ti4+, and W6+ is equal to or greater than 50%; and in that the Knoop hardness is equal to or higher than 370, the refractive index nd is equal to or higher than 2.02, and the Abbé number vd is equal to or lower than 19.0. A glass material for press molding and an optical element comprised of this optical glass. A method for manufacturing a glass material for press molding comprising the step of mechanically processing this optical glass. |
| US08716152B2 |
Method of controlling silicon oxide film thickness
A deposition process for coating a substrate with films of a different thickness on front and rear surface of a substrate can be achieve in one growth. The thickness of the film deposition can be controlled by the separation between the substrates. Different separation distances between the substrates in the same chemical bath will result in different film thicknesses on the substrate. Substrates may be arranged to have different separation distances between front and back surfaces, a V-shaped arrangement, or placed next to a curtain with varying separation distances between a substrate and the curtain. |
| US08716145B2 |
Critical concentration in etching doped poly silicon with HF/HNO3
In some embodiments, the present invention discloses an etchant solution hydrochloric acid and nitric acid to etch doped polysilicon at low etch rates. The doped polysilicon can be doped with Ge, In, B and Ga. Preferably, the concentration of hydrochloric acid can be greater than 1 vol %, and the concentration of nitric acid is greater than 15 vol %. |
| US08716143B1 |
Plasma based photoresist removal system for cleaning post ash residue
A method of cleaning a low dielectric constant film in a lithographic process includes providing a dielectric film having thereover a resist composition, the dielectric film having a dielectric constant no greater than about 4.0, and stripping the resist composition to leave a substantially silicon-containing ash residue on the dielectric film. The method then includes contacting the ash residue with plasma comprising an ionized, essentially pure noble gas such as helium to remove the resist residue without substantially affecting the underlying dielectric film. |
| US08716141B2 |
Electrode configurations for semiconductor devices
A III-N semiconductor device can include an electrode-defining layer having a thickness on a surface of a III-N material structure. The electrode-defining layer has a recess with a sidewall, the sidewall comprising a plurality of steps. A portion of the recess distal from the III-N material structure has a first width, and a portion of the recess proximal to the III-N material structure has a second width, the first width being larger than the second width. An electrode is in the recess, the electrode including an extending portion over the sidewall of the recess. A portion of the electrode-defining layer is between the extending portion and the III-N material structure. The sidewall forms an effective angle of about 40 degrees or less relative to the surface of the III-N material structure. |
| US08716138B2 |
Method for fabricating a field side sub-bitline nor flash array
Field Side Sub-bitline NOR-type (FSNOR) flash array and the methods of fabrication are disclosed. The field side sub-bitlines of the invention formed with the same impurity type as the memory cells' source/drain electrodes along the two sides of field trench oxide link all the source electrodes together and all the drain electrodes together, respectively, for a string of semiconductor Non-Volatile Memory (NVM) cells in a NOR-type flash array of the invention. Each field side sub-bitline is connected to a main metal bitline through a contact at its twisted point in the middle. Because there are no contacts in between the linked NVM cells' electrodes in the NOR-type flash array of the invention, the wordline pitch and the bitline pitch can be applied to the minimum geometrical feature of a specific technology node. The NOR-type flash array of the invention provides at least as high as those in the conventional NAND flash array in cell area density. |
| US08716135B1 |
Method of eliminating a lithography operation
Methods of semiconductor device fabrication techniques using double patterning are disclosed. According to various embodiments of the invention, methods of semiconductor device fabrication using self-aligned double patterning are provided. Particular embodiments of the invention allow creation of logic circuit patterns using two lithographic operations. One embodiment of the invention employs self-aligned double patterning to define two or more sets of parallel line features with a connection feature between the sets. In such embodiments, the sets of parallel line features along with the connection features are formed using two lithographic masks, without the need for an additional mask layer to form the connection. In other embodiments, other features in addition to the connection can be added in the same mask layer. |
| US08716134B2 |
Interconnect structure employing a Mn-group VIIIB alloy liner
A metallic liner stack including at least a Group VIIIB element layer and a CuMn alloy layer is deposited within a trench in a dielectric layer. Copper is deposited on the metallic liner stack and planarized to form a conductive interconnect structure, which can be a metal line, a metal via, or a combination thereof. The deposited copper and the metallic liner stack are annealed before or after planarization. The Mn atoms are gettered by the Group VIIIB element layer to form a metallic alloy liner including Mn and at least one of Group VIIIB elements. Mn within the metallic alloy liner combines with oxygen during the anneal to form MnO, which acts as a strong barrier to oxygen diffusion, thereby enhancing the reliability of the conductive interconnect structure. |
| US08716126B2 |
Semiconductor device comprising self-aligned contact bars and metal lines with increased via landing regions
Disclosed herein is an illustrative semiconductor device that includes a transistor having drain and source regions and a gate electrode structure. The disclosed semiconductor device also includes a contact bar formed in a first dielectric material that connects to one of the drain and source regions and includes a first conductive material, the contact bar extending along a width direction of the transistor. Moreover, the illustrative device further includes, among other things, a conductive line formed in a second dielectric material, the conductive line including an upper portion having a top width extending along a length direction of the transistor and a lower portion having a bottom width extending along the length direction that is less than the top width of the upper portion, wherein the conductive line connects to the contact bar and includes a second conductive material that differs from the first conductive material. |
| US08716118B2 |
Replacement gate structure for transistor with a high-K gate stack
A transistor includes a semiconductor layer and a gate structure located on the semiconductor layer. The gate structure includes a first dielectric layer. The first dielectric layer includes a doped region and an undoped region below the doped region. A second dielectric layer is located on the first dielectric layer, and a first metal nitride layer is located on the second dielectric layer. The doped region of the first dielectric layer comprises dopants from the second dielectric layer. Source and drain regions in the semiconductor layer are located on opposite sides of the gate structure. |
| US08716110B2 |
Laser processing method and laser processing apparatus
A laser processing method comprising a step of irradiating an object to be processed with laser light elliptically polarized with an ellipticity of other than 1 such that a light-converging point of the laser light is located within the object along the major axis of an ellipse indicative of the elliptical polarization of laser light, along a line which the object is intended to be cut, to form a modified region caused by multiphoton absorption within the object, along the line which the object is intended to be cut. |
| US08716106B2 |
Method for producing a bonded substrate
A method for producing a bonded substrate having a Si1-xGex (0 |
| US08716105B2 |
Methods for bonding semiconductor structures involving annealing processes, and bonded semiconductor structures and intermediate structures formed using such methods
Methods of bonding together semiconductor structures include annealing metal of a feature on a semiconductor structure prior to directly bonding the feature to a metal feature of another semiconductor structure to form a bonded metal structure, and annealing the bonded metal structure after the bonding process. The thermal budget of the first annealing process may be at least as high as a thermal budget of a later annealing process. Additional methods involve forming a void in a metal feature, and annealing the metal feature to expand the metal of the feature into the void. Bonded semiconductor structures and intermediate structures are formed using such methods. |
| US08716103B2 |
Semiconductor device and method of fabricating same
A semiconductor device having a core device with a high-k gate dielectric and an I/O device with a silicon dioxide or other non-high-k gate dielectric, and a method of fabricating such a device. A core well and an I/O well are created in a semiconductor substrate and separated by an isolation structure. An I/O device is formed over the I/O well and has a silicon dioxide or a low-k gate dielectric. A resistor may be formed on an isolation structure adjacent to the core well. A core-well device such as a transistor is formed over the core well, and has a high-k gate dielectric. In some embodiments, a p-type I/O well and an n-type I/O well are created. In a preferred embodiment, the I/O device or devices are formed prior to forming the core device and protected with a sacrificial layer until the core device is fabricated. |
| US08716099B2 |
Phase-change memory
A phase-change memory element with side-wall contacts is disclosed, which has a bottom electrode. A non-metallic layer is formed on the electrode, exposing the periphery of the top surface of the electrode. A first electrical contact is on the non-metallic layer to connect the electrode. A dielectric layer is on and covering the first electrical contact. A second electrical contact is on the dielectric layer. An opening is to pass through the second electrical contact, the dielectric layer, and the first electrical contact and preferably separated from the electrode by the non-metallic layer. A phase-change material is to occupy one portion of the opening, wherein the first and second electrical contacts interface the phase-change material at the side-walls of the phase-change material. A second non-metallic layer may be formed on the second electrical contact. A top electrode contacts the top surface of the outstanding terminal of the second electrical contact. |
| US08716098B1 |
Selective removal method and structure of silver in resistive switching device for a non-volatile memory device
A method for forming a non-volatile memory device includes providing a substrate having a surface region, forming a first wiring structure overlying the surface region, depositing a first dielectric material overlying the first wiring structure, forming a via opening in the first dielectric material to expose a portion of the first wiring structure, while maintaining a portion of the first dielectric material, forming a layer of resistive switching material comprising silicon, within the via opening, forming a silver material overlying the layer of resistive switching material and the portion of the first dielectric material, forming a diffusion barrier layer overlying the silver material, and selectively removing a portion of the silver material and a portion of the diffusion barrier layer overlying the portion of the first dielectric material while maintaining a portion of the silver material and a portion of the diffusion barrier material overlying the layer of silicon material. |
| US08716097B2 |
MOS transistors having reduced leakage well-substrate junctions
A Metal-Oxide Semiconductor (MOS) transistor includes a substrate having a topside semiconductor surface doped with a first dopant type having a baseline doping level. A well is formed in the semiconductor surface doped with a second doping type. The well forms a well-substrate junction having a well depletion region. A retrograde doped region is below the well-substrate junction doped with the first dopant type having a peak first dopant concentration of between five (5) and one hundred (100) times above the baseline doping level at a location of the peak first dopant concentration, wherein with zero bias across the well-substrate junction at least (>) ninety (90) % of a total dose of the retrograde doped region is below the bottom of the well depletion region. A gate structure is on the well. Source and drain regions are on opposing sides of the gate structure. |
| US08716094B1 |
FinFET formation using double patterning memorization
Approaches for forming a FinFET device using double patterning memorization techniques are provided. Specifically, a device will initially be formed by defining a set of fins, depositing a poly-silicon layer, and depositing a hardmask. Thereafter, a front end of the line (FEOL) lithography-etch, lithography-etch (LELE) process will be performed to form a set of trenches in the device. The set of trenches will be filled with an oxide layer that is subsequently polished. Thereafter, the device is selectively etched to yield a (e.g., poly-silicon) gate pattern. |
| US08716092B2 |
Method for fabricating MOS transistors
A method for fabricating a MOS transistor is disclosed. First, a semiconductor substrate having a gate thereon is provided. A spacer is then formed on the sidewall of the gate, and two recesses are formed adjacent to the spacer and within the semiconductor substrate. Next, the spacer is thinned, and epitaxial layer is grown in each of the two recesses. By thinning the spacer before the epitaxial layer is formed, the present invention could stop the epitaxial layer to grow against the sidewall of the spacer, thereby preventing problem such as Ion degradation. |
| US08716091B2 |
Structure for self-aligned silicide contacts to an upside-down FET by epitaxial source and drain
A method for fabricating an upside-down p-FET includes: fully etching source and drain regions in a donor substrate by etching a silicon-on-insulator layer through buried oxide and partially etching the silicon substrate; refilling a bottom and sidewall surfaces of the etched source and drain regions with epitaxial silicide/germanide to form e-SiGe source and drain regions; capping the source and drain regions with self-aligning silicide/germanide; providing a silicide layer formed over the gate conductor line; providing a first stress liner over the gate and the e-SiGe source and drain regions; depositing a planarized dielectric over the self-aligning silicide/germanide; inverting the donor substrate; bonding the donor substrate to a host wafer; and selectively exposing the buried oxide and the e-SiGe source and drain regions by removing the donor wafer. |
| US08716083B2 |
Unitary floating-gate electrode with both N-type and P-type gates
An analog floating-gate electrode in an integrated circuit, and method of fabricating the same, in which trapped charge can be stored for long durations. The analog floating-gate electrode is formed in a polycrystalline silicon gate level, and includes n-type and p-type doped portions serving as gate electrodes of n-channel and p-channel MOS transistors, respectively; a plate of a metal-to-poly storage capacitor; and a plate of poly-to-active tunneling capacitors. Silicide-block silicon dioxide blocks the formation of silicide cladding on the electrode, while other polysilicon structures in the integrated circuit are silicide-clad. An opening at the surface of the analog floating-gate electrode, at the location at which n-type and p-type doped portions of the floating gate electrode abut, allow formation of silicide at that location, shorting the p-n junction. |
| US08716082B2 |
Semiconductor device, method of controlling the same, and method of manufacturing the same
The present invention provides a system comprising a semiconductor device, a method of controlling the semiconductor device in the system, and a method of manufacturing the semiconductor device in the system. The semiconductor device includes: a semiconductor region located in a semiconductor layer formed on an isolating layer; an ONO film on the semiconductor region; bit lines on either side of the semiconductor region, which are located in the semiconductor layer, and are in contact with the isolating layer; a device isolating region on two different sides of the semiconductor region from the sides on which the bit lines are located, the device isolating region being in contact with the isolating layer; and a first voltage applying unit that is coupled to the semiconductor region. In this semiconductor device, the semiconductor region is surrounded by the bit lines and the device isolating region, and is electrically isolated from other semiconductor regions. |
| US08716081B2 |
Capacitor top plate over source/drain to form a 1T memory device
A method and structure for a memory device, such as a 1T-SRAM, having a capacitor top plate directly over a doped bottom plate region. An example device comprises the following. An isolation film formed as to surround an active area on a substrate. A gate dielectric and gate electrode formed over a portion of the active area. A source element and a drain element in the substrate adjacent to the gate electrode. The drain element is comprised of a drain region and a bottom plate region. The drain region is between the bottom plate region and the gate structure. A capacitor dielectric and a capacitor top plate are over at least portions of the bottom plate region. |
| US08716077B2 |
Replacement gate compatible eDRAM transistor with recessed channel
An eDRAM is fabricated including high performance logic transistor technology and ultra low leakage DRAM transistor technology. Embodiments include forming a recessed channel in a substrate, forming a first gate oxide to a first thickness lining the channel and a second gate oxide to a second thickness over a portion of an upper surface of the substrate, forming a first polysilicon gate in the recessed channel and overlying the recessed channel, forming a second polysilicon gate on the second gate oxide, forming spacers on opposite sides of each of the first and second polysilicon gates, removing the first and second polysilicon gates forming first and second cavities, forming a high-k dielectric layer on the first and second gate oxides, and forming first and second metal gates in the first and second cavities, respectively. |
| US08716074B2 |
Methods for forming isolated fin structures on bulk semiconductor material
Methods are provided for fabricating a semiconductor device. A method comprises forming a layer of a first semiconductor material overlying the bulk substrate and forming a layer of a second semiconductor material overlying the layer of the first semiconductor material. The method further comprises creating a fin pattern mask on the layer of the second semiconductor material and anisotropically etching the layer of the second semiconductor material and the layer of the first semiconductor material using the fin pattern mask as an etch mask. The anisotropic etching results in a fin formed from the second semiconductor material and an exposed region of first semiconductor material underlying the fin. The method further comprises forming an isolation layer in the exposed region of first semiconductor material underlying the fin. |
| US08716073B2 |
Method for processing oxide semiconductor film and method for manufacturing semiconductor device
To provide an oxide semiconductor film including a low-resistance region, which can be applied to a transistor. To provide a transistor including the oxide semiconductor film, which can perform at high speed. To provide a high-performance semiconductor device including the transistor including the oxide semiconductor film, which can perform at high speed, with high yield. A film having a reducing property is formed over the oxide semiconductor film. Next, part of oxygen atoms are transferred from the oxide semiconductor film to the film having a reducing property. Next, an impurity is added to the oxide semiconductor film through the film having a reducing property and then, the film having a reducing property is removed, so that a low-resistance region is formed in the oxide semiconductor film. |
| US08716069B2 |
Semiconductor device employing aluminum alloy lead-frame with anodized aluminum
A semiconductor device comprises an aluminum alloy lead-frame with a passivation layer covering an exposed portion of the aluminum alloy lead-frame. Since aluminum alloy is a low-cost material, and its hardness and flexibility are suitable for deformation process, such as punching, bending, molding and the like, aluminum alloy lead frame is suitable for mass production; furthermore, since its weight is much lower than copper or iron-nickel material, aluminum alloy lead frame is very convenient for the production of semiconductor devices. |
| US08716067B2 |
Power device manufacture on the recessed side of a thinned wafer
A recess is formed into a first side of a wafer such that a thinned center portion of the wafer is formed, and such that the central portion is surrounded by a thicker peripheral edge support portion. The second side of the wafer remains substantially entirely planar. After formation of the thinned wafer, vertical power devices are formed into the first side of the central portion of the wafer. Formation of the devices involves forming a plurality of diffusion regions into the first side of the thinned central portion. Metal electrodes are formed on the first and second sides, the peripheral portion is cut from the wafer, and the thin central portion is diced to form separate power devices. In one example, a first commercial entity manufactures the thinned wafers, and a second commercial entity obtains the thinned wafers and performs subsequent processing to form the vertical power devices. |
| US08716062B1 |
Array substrate and method of fabricating the same
A method of fabricating an array substrate and a display device including the array substrate are discussed. According to an embodiment, the array substrate includes a gate electrode formed on a substrate; a gate insulating layer formed on the gate electrode; an oxide semiconductor layer and an etch prevention layer formed on the gate insulating layer, wherein ends of the oxide semiconductor layer and ends of the etch prevention layer are aligned with each other; source and drain electrodes formed on the etch prevention layer; a passivation layer including a contact hole formed on the source and drain electrodes and on the gate insulating layer; and a pixel electrode formed on the passivation layer and through the contact hole. |
| US08716057B2 |
Organic EL display device
An organic EL display device includes a pixel electrode which is disposed in each of first to third organic EL elements, a first light emission layer which includes a first dopant material having a first absorbance peak, the first light emission layer extending over the first to third organic EL elements and being disposed above the pixel electrode, a second light emission layer which includes a second dopant material having a second absorbance peak and is disposed above the first light emission layer, a third light emission layer which is disposed above the second light emission layer, a counter-electrode which is disposed above the third light emission layer, and a hole transport layer which is formed of a material having an absorbance bottom on a shorter wavelength side than the first absorbance peak and the second absorbance peak in absorbance spectrum characteristics of the hole transport layer. |
| US08716056B2 |
Method for forming chalcogenide switch with crystallized thin film diode isolation
A three-dimensional memory array formed of one or more two-dimensional memory arrays of one-time programmable memory elements arranged in horizontal layers and stacked vertically upon one another; and a two-dimensional memory array of reprogrammable phase change memory elements stacked on the one or more two-dimensional memory arrays as the top layer of the three-dimensional memory array. |
| US08716044B2 |
Optical semiconductor device having ridge structure formed on active layer containing P-type region and its manufacture method
A p-type cladding layer (3) of p-type semiconductor is formed over a substrate. An active layer (5) including a p-type semiconductor region is disposed over the p-type cladding layer. A buffer layer (10) of non-doped semiconductor is disposed over the active layer. A ridge-shaped n-type cladding layer (11) of n-type semiconductor is disposed over a partial surface of the buffer layer. The buffer layer on both sides of the ridge-shaped n-type cladding layer is thinner than the buffer layer just under the ridge-shaped n-type cladding layer. |
| US08716040B2 |
Organic light emitting diode display and method for manufacturing the same
An organic light emitting diode (OLED) display and a manufacturing method thereof, the OLED display includes: a substrate main body; a polycrystalline silicon layer pattern including a polycrystalline active layer formed on the substrate main body and a first capacitor electrode; a gate insulating layer pattern formed on the polycrystalline silicon layer pattern; a first conductive layer pattern including a gate electrode and a second capacitor electrode that are formed on the gate insulating layer pattern; an interlayer insulating layer pattern formed on the first conductive layer pattern; and a second conductive layer pattern including a source electrode, a drain electrode and a pixel electrode that are formed on the interlayer insulating layer pattern. The gate insulating layer pattern is patterned at a same time with any one of the polycrystalline silicon layer pattern and the first conductive layer pattern. |
| US08716039B2 |
Monitoring apparatus and method for in-situ measurement of wafer thicknesses for monitoring the thinning of semiconductor wafers and thinning apparatus comprising a wet etching apparatus and a monitoring apparatus
According to the invention, a monitoring device (12) is created for monitoring a thinning of at least one semiconductor wafer (4) in a wet etching unit (5), wherein the monitoring device (12) comprises a light source (14), which is designed to emit coherent light of a light wave band for which the semiconductor wafer (4) is optically transparent. The monitoring device (12) further comprises a measuring head (13), which is arranged contact-free with respect to a surface of the semiconductor wafer (4) to be etched, wherein the measuring head (13) is designed to irradiate the semiconductor wafer (4) with the coherent light of the light wave band and to receive radiation (16) reflected by the semiconductor wafer (4). Moreover, the monitoring device (12) comprises a spectrometer (17) and a beam splitter, via which the coherent light of the light wave band is directed to the measuring head (13) and the reflected radiation is directed to the spectrometer (17). The monitoring device (12) further comprises an evaluation unit (18), wherein the evaluation unit (18) is designed to determine a thickness d(t) of the semiconductor wafer (4) from the radiation (16) reflected by the semiconductor wafer (4) during thinning of the semiconductor wafer (4) by means of a method that is selected from the group consisting of a 1D-se FDOCT method, a 1D-te FDOCT method and a 1D-se TDOCT method. |
| US08716038B2 |
Microelectronic workpiece processing systems and associated methods of color correction
Several embodiments of semiconductor systems and associated methods of color corrections are disclosed herein. In one embodiment, a method for producing a light emitting diode (LED) includes forming an (LED) on a substrate, measuring a base emission characteristic of the formed LED, and selecting a phosphor based on the measured base emission characteristic of the formed LED such that a combined emission from the LED and the phosphor at least approximates white light. The method further includes introducing the selected phosphor onto the LED via, for example, inkjet printing. |
| US08716037B2 |
Measurement of CMOS device channel strain by X-ray diffraction
A direct measurement of lattice spacing by X-ray diffraction is performed on a periodic array of unit structures provided on a substrate including semiconductor devices. Each unit structure includes a single crystalline strained material region and at least one stress-generating material region. For example, the single crystalline strained material region may be a structure simulating a channel of a field effect transistor, and the at least one stress-generating material region may be a single crystalline semiconductor region in epitaxial alignment with the single crystalline strained material region. The direct measurement can be performed in-situ at various processing states to provide in-line monitoring of the strain in field effect transistors in actual semiconductor devices. |
| US08716028B2 |
Control over hydrogen fluoride levels in oxide etchant
The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe. |
| US08716026B2 |
Methods and systems for determining composition and completion of an experiment
Methods and systems for determining composition and completion of an experiment are provided. One-computer-implemented method for determining composition and completion of an experiment includes determining one or more characteristics of data acquired during the experiment and determining if the experiment is completed based on the one or more characteristics. One system configured to determine composition and completion of an experiment includes a processor configured to determine one or more characteristics of data acquired during the experiment and to determine if the experiment is completed based on the one or more characteristics. Another system configured to perform an experiment includes a measurement subsystem configured to acquire data during the experiment and a processor configured to determine one or more characteristics of the data during the experiment and to determine the composition of the experiment and if the experiment is completed based on the one or more characteristics. |
| US08716025B2 |
Drifting two-dimensional separation with adaption of second dimension gradient to actual first dimension condition
A control device for a sample separation apparatus, the sample separation apparatus including a first separation unit and a second separation unit downstream of the first separation unit and supplied with the fluidic sample after treatment by the first separation unit. A control device is configured for controlling the first separation unit to execute a primary separation sequence within a time interval for separating the fluidic sample into fractions, and for controlling the second separation unit to execute secondary separation sequences within the time interval for further separating the separated fractions into sub-fractions, wherein the secondary separation sequences form part of a common sample separation method defined by a common specification of the sample separation involving a set of parameters, and adjusting, over a progress of the primary separation sequence, at least one parameter according to which at least one of the plurality of secondary separation sequences is executed. |
| US08716021B2 |
Use of replicators to prevent gene silencing
Regulatory elements, specifically replicators and transgene constructs containing replicator nucleic acid sequences, are disclosed herein. Methods of using replicators and transgene constructs including replicators to inhibit, delay, or prevent gene silencing are also disclosed herein. |
| US08716017B2 |
Technologies, methods, and products of small molecule directed tissue and organ regeneration from human pluripotent stem cells
Pluripotent human embryonic stem cells (hESCs) hold great potential for restoring tissue and organ function, which has been hindered by inefficiency and instability of generating desired cell types through multi-lineage differentiation. This instant invention is based on the discovery that pluripotent hESCs maintained under defined culture conditions can be uniformly converted into a specific lineage by small molecule induction. Retinoic acid induces specification of neuroectoderm direct from the pluripotent state of hESCs and triggers progression to neuronal progenitors and neurons efficiently. Similarly, nicotinamide induces specification of cardiomesoderm direct from the pluripotent state of hESCs and triggers progression to cardiac precursors and cardiomyocytes efficiently. This technology provides a large supply of clinically-suitable human neuronal or cardiac therapeutic products for CNS or myocardium repair. This invention enables well-controlled efficient induction of pluripotent hESCs exclusively to a specific clinically-relevant lineage for tissue and organ engineering and regeneration, cell-based therapy, and drug discovery. |
| US08716014B2 |
Adenovirus E1A fragments for use in anti-cancer therapies
The present invention relates to an improved cancer therapy comprising co-administration with the E1A 1-80 transcription-repression domain activity. In addition, E1A 1-80 can act as a monotherapy against cancers that express elevated HER2/Neu or in combination with anti-HER2/Neu, chemo- or radiotherapeutic treatments. |
| US08716012B2 |
Alpha thymosin peptides as vaccine enhancers
The present invention provides methods of vaccination as well as pharmaceutical combinations and kits for enhancing vaccine effectiveness, including for immunodeficient or immunecompromised patients, including non-responders and low-responders to vaccination. As disclosed herein, the invention relates to administering a vaccine and a regimen of thymosin alpha peptide so as to provide higher antibody titers, speed the development of such antibody titers, and/or to provide for a longer duration of such antibody titers, thereby providing a greater protective effect. In another aspect, the invention allows for reducing a vaccine dose, such as an influenza vaccine dose, by administration of a thymosin peptide regimen. |
| US08716011B2 |
Transcriptional control in Alicyclobacillus acidocaldarius and associated genes, proteins, and methods
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of modulating transcription or transcription or transcriptional control using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius. |
| US08716007B2 |
Portable high gain fluorescence detection system
An instrument for fluorometric assays in liquid samples is disclosed. The instrument may include multiple optical channels for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. The disclosed instrument finds utility in any number of applications, including microfluidic molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general. |
| US08716006B2 |
Multi-chamber rotating valve
A fluid delivery system having a rotating reservoir insert and a cartridge body. The rotating reservoir insert having a plurality of reservoirs in communication with ports on the external surface of the insert. The ports are positioned such that upon rotation the port is in-line with a fluid extracting device, such as a syringe, capable of extracting fluid from the reservoir. |
| US08716005B2 |
Method and device to probe a membrane by applying an in-plane electric field
The present invention disposes a membrane between two electrical conductive walls having a height at least as great as the thickness of the membrane. The conductive walls are fabricated on an electrically insolative chip base. The chip base has one or more through hole between the electrically conducting walls. The chip is placed inside a container having a well below the through hole of the electrically insolative base. At least one passageway extends from the well to the periphery of the container. This invention probes changes of the membrane as an in-plane electric field is applied between the conductive walls. The well may include various compounds while-other compounds can be placed in contact with the top of the membrane. The passageways are used to introduce substances into and out of the well. |
| US08716002B2 |
Re-engineering bacteria for ethanol production
The invention provides recombinant bacteria, which comprise a full complement of heterologous ethanol production genes. Expression of the full complement of heterologous ethanol production genes causes the recombinant bacteria to produce ethanol as the primary fermentation product when grown in mineral salts medium, without the addition of complex nutrients. Methods for producing the recombinant bacteria and methods for producing ethanol using the recombinant bacteria are also disclosed. |
| US08716001B2 |
Trichoderma strains that induce resistance to plant diseases and/or increase plant growth
A method for enhancing growth of plants comprising contacting a Trichoderma strain with the plant or a plant seed under conditions effective for the Trichoderma strain to colonize the roots of the plant or a plant grown from the plant seed, thereby creating a plant-Trichoderma system. The plant or plant seed is grown under conditions effective to sustain the plant-Trichoderma system in a planting medium and to enhance plant growth. The Trichoderma strain is selected from the group consisting of Trichoderma atroviride strain WW10TC4 (ATCC accession number PTA 9707), Trichoderma harzianum strain RR17Bc (ATCC accession number PTA 9708), Trichoderma harzianum strain F11 Bab (ATCC accession number PTA 9709), and combinations thereof. Methods of enhancing resistance of plants to abiotic stress, increasing nitrogen use efficacy in plants, reducing nitrous oxide emissions in air, reducing leaching of nitrates into soil and water, and enhancing sequestration of carbon from air are disclosed. |
| US08715999B2 |
Flaviviridae mutants comprising a deletion in the capsid protein for use as vaccines
The present invention relates to a mutant virus of the family flaviviridae, comprising a deletion in the capsid protein of at least 20 successive amino acids, without any further deletion, substitution or insertion mutation except of the amino acids next to the deletion, which may be substituted. |
| US08715995B2 |
Polypeptides having beta-glucosidase activity and beta-xylosidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. |
| US08715993B2 |
Glycosidase enzymes
A thermostable glycosidase enzymes derived from various Thermococcus, Staphylothermus and Pyrococcus organisms is disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the food processing industry, pharmaceutical industry and in the textile industry, detergent industry and in the baking industry. |
| US08715992B2 |
I-CreI meganuclease variants with modified specificity, method of preparation and uses thereof
Method of preparing I-CreI meganuclease variants having a modified cleavage specificity, variants obtainable by said method and their applications either for cleaving new DNA target or for genetic engineering and genome engineering for non-therapeutic purposes. Nucleic acids encoding said variants, expression cassettes comprising said nucleic acids, vectors comprising said expression cassettes, cells or organisms, plants or animals except humans, transformed by said vectors. |
| US08715991B2 |
DNA polymerases with increased 3'-mismatch discrimination
Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. |
| US08715988B2 |
Alkane oxidation by modified hydroxylases
This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells. |
| US08715987B2 |
Solubilized phospholipids for stabilizing nucleic acid polymerases
Compositions and methods are provided that relate to solubilized phospholipids and their use in stabilizing nucleic acid polymerases. For example, a phospholipid with a tail containing at least 8 carbons can be solubilized in the presence of an amphipathic molecule. |
| US08715984B2 |
Modified tRNA containing unnatural base and use thereof
In the method for introducing a noncanonical amino acid residue into a desired position in a protein, the structure of tRNA is so modified as to have improved affinity for aminoacyl-tRNA synthetase or improved specificity to aminoacyl-tRNA synthetase. An unnatural base is contained at any position in tRNA, whereby the efficiency of aminoacylation of the tRNA with a noncanonical amino acid can be improved. |
| US08715979B2 |
Method of producing filamentous fungus culture product
It is an object of the present invention to provide a method of adjusting productivity of enzymes, in particular, amylolytic enzymes, plant fiber degradation enzymes and proteolytic enzymes in a filamentous fungus culture product, by controlling releasing rate of nutrients from the culture raw material into the culture system when a filamentous fungus culture product is produced by culturing filamentous fungi in liquid medium containing as the culture raw material at least one selected from the group consisting of cereals, beans, tubers, amaranthus and quinoa. The present invention provides a method of producing filamentous fungus culture product by using liquid medium containing as culture raw material at least one selected from the group consisting of cereals, beans, tubers, amaranthus and quinoa comprising, culturing filamentous fungi while releasing rate of nutrients from the culture raw material into the culture system is controlled to adjust productivity of enzymes in the filamentous fungus culture product. |
| US08715978B2 |
Generation of hydrogen from hydrocarbon bearing materials
Disclosed are strategies for the economical microbial generation of hydrogen, useful as an alternative energy source, from hydrocarbon-rich deposits such as coal, oil and/or gas formations, oil shale, bitumen, tar sands, carbonaceous shale, peat deposits and sediments rich in organic matter through the management of the metabolism of microbial consortia. |
| US08715975B2 |
Method for producing an alcohol using β-glucosidase variant enzymes
The invention provides variants of the Azospirillum irakense CelA β-glucosidase that have improve β-glucosidase activity, particularly improved thermoactivity, compared to the wild type enzyme. The invention further provides related polynucleotides, vectors, host cell, and methods for making and using the variants. |
| US08715974B2 |
Method for producing scyllo-inositol
It is intended to provide a novel NAD+-independent myo-inositol 2-dehydrogenase which converts myo-inositol into scyllo-inosose in the absence of NAD+; a novel enzyme scyllo-inositol dehydrogenase which stereospecifically reduces scyllo-inosose into scyllo-inositol in the presence of NADH or NADPH; and a novel microorganism which belongs to the genus Acetobacter or Burkholderia and can convert myo-inositol into scyllo-inositol. By using these enzymes or the microorganism, scyllo-inositol is produced. Furthermore, scyllo-inositol is purified by adding boric acid and a metal salt to a liquid mixture containing scyllo-inositol and a neutral saccharide other than scyllo-inositol to form a scyllo-inositol/boric acid complex, separating the complex from the liquid mixture, dissolving the thus separated complex in an acid to give an acidic solution or an acidic suspension and then purifying scyllo-inositol from the acidic solution or the acidic suspension. |
| US08715973B1 |
Organic acid-tolerant microorganisms and uses thereof for producing organic acids
Organic acid-tolerant microorganisms and methods of using same. The organic acid-tolerant microorganisms comprise modifications that reduce or ablate AcsA activity or AcsA homolog activity. The modifications increase tolerance of the microorganisms to such organic acids as 3-hydroxypropionic acid (3HP), acrylic acid, and propionic acid. Further modifications to the microorganisms such as increasing expression of malonyl-CoA reductase and/or acetyl-CoA carboxylase provide or increase the ability of the microorganisms to produce 3HP. Methods of generating an organic acid with the modified microorganisms are provided. Methods of using acsA or homologs thereof as counter-selectable markers include replacing acsA or homologs thereof in cells with genes of interest and selecting for the cells comprising the genes of interest with amounts of organic acids effective to inhibit growth of cells harboring acsA or the homologs. |
| US08715962B2 |
Production of geranyl diphosphate
The invention relates to recombinant geranyl diphosphate (GPP) synthases, genes encoding the synthases, vectors and host cells comprising the same. More particularly, the invention relates to a recombinant GPP synthase, which preferentially facilitates the production of GPP from its isoprenoid precursors and incorporating a recombinant GPP synthase into one or more terpene production pathways of a host organism. |
| US08715956B2 |
Method for the intensive extraction of cellular compounds from micro-organisms by continuous culture and extraction, and corresponding device
A method is provided for extracting cellular compounds from micro-organisms. The method includes culturing the micro-organisms and extracting the cellular compounds from the micro-organisms. Each step is carried out in a continuous manner, wherein the extraction step is carried out separately from the culture step and in conditions of biocompatibility with the micro-organisms. The method further includes at least one step of recovering the cellular compounds and at least one step of recirculating the micro-organisms towards the culture step. |
| US08715954B2 |
Method of producing C3A serum-free clonal cell line
A serum-free C3A clonal cell line and methods for generating the same are provided. The C3A cell line has a reduced doubling time in serum-free medium compared to a corresponding C3A cell line from which it is derived. Methods using the cells of the serum-free C3A clonal cell line for the production, expression and recovery of harvestable polypeptides, screening compounds for metabolic activity, studying enteric disease and for use in a bio-artificial liver device are also provided. |
| US08715952B2 |
Acetaminophen assay
In general, the present invention provides a reliable assay for the quantitative determination of p-aminophenol in an aqueous sample. More particularly, the present invention provides a rapid enzyme-based assay for the quantitative determination of acetaminophen in a sample. The assay employs a xylenol chromophore and a catalyst that is preferably a weak oxidizer. The assay provides reliable results in the presence or absence of N-acetylcystiene (NAC) and can therefore be used to monitor acetaminophen levels during NAC treatment. Methods and kits for determining acetaminophen concentration in an aqueous sample are also provided. |
| US08715951B2 |
Highly sensitive immunoassays and antibodies for detection of blood factor VIII
Disclosed are antibodies that selectively bind to blood coagulation factor FVIII, and highly sensitive immunological assays comprising these antibodies. Preferred assays can detect FVIII at about 3500-fold below the normal physiological levels, and have a wide array of applications including accurate monitoring of FVIII concentration in pharmaceutical products for treatment of blood coagulation disorders, and determination of FVIII levels in plasma of human patients, including those with blood coagulation disorders such as hemophilia. |
| US08715950B2 |
Kits for luminogenic and nonluminogenic multiplex assays
Methods and kits to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay are provided. |
| US08715948B2 |
Granzyme A and granzyme B diagnostics
A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of GrA and/or GrB in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of GrA and/or GrB may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease. The method may further include identifying concentrations of fibrinogen, elastin and/or fibrillin. |
| US08715944B2 |
Fluorochromes for organelle tracing and multi-color imaging
Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest. |
| US08715941B2 |
Antibodies to LRP6
Anti-LRP6 antibodies and antigen-binding fragments thereof, as well as pharmaceutical compositions comprising such antibodies and antigen-binding fragments are described. These anti-LRP6 antibodies can be used to enhance Wnt activity and/or antagonize Dkk1 activity. Also described are methods of therapy using such antibodies and antigen-binding regions to bind modulate Wnt/LRP6 signaling to promote tissue homeostasis, regeneration and repair in diseases such as, but not limited to, bone disorders, such as osteoporosis, rheumatoid arthritis, and osteolytic lesions caused by osteoarthritis and multiple myeloma, gastrointestinal disease and wound healing. |
| US08715937B2 |
Mutation detection assay
A method of sample analysis is provided. In certain embodiments, the method involves: a) amplifying a product from a sample that comprises both wild type copies of a genomic locus and mutant copies of the genomic locus that have a point mutation relative to the wild type copies of the genomic locus, to produce an amplified sample, where: i. the amplifying is done using a first primer and a second primer; and ii. the first primer comprises a 3′ terminal nucleotide that base pairs with the point mutation and also comprises a nucleotide sequence that is fully complementary to a sequence in the locus with the exception of a single base mismatch within 6 bases of the 3′ terminal nucleotide; and b) detecting the presence of the product in the amplified sample using a flap assay that employs an invasive oligonucleotide. A kit for performing the method is also provided. |
| US08715933B2 |
Assay methods using nicking endonucleases
Assay methods and apparatus for the analysis of biopolymers are disclosed. The assays employ nicking endonucleases to enable the generation of flaps on target biomolecules which are detected in nanopore or fluidic channel devices. Identification of flap locations enables a map of the target biomolecule to be derived. |
| US08715927B2 |
Inhibition of DNA polymerases to augment chemotherapeutic and antimicrobial agents
Disclosed herein is the identification of human DNA polymerase κ (pol κ) as the polymerase that mediates repair of DNA containing interstrand cros slinks (ICLs). The mechanism of action of a number of chemotherapeutic and antimicrobial agents is the induction of ICLs. Thus, provided herein is a method of enhancing the efficacy of a chemotherapeutic or antimicrobial agent in a subject, including selecting a subject in need of treatment with an ICL -inducing agent and administering to the subject an ICL-inducing agent and a therapeutically effective amount of an inhibitor of pol κ. Also provided is a composition for treating a hyperproliferative disease, an autoimmune disease or an infectious disease, comprising an ICL-inducing agent and an amount of an inhibitor of pol κ sufficient to enhance the efficacy of the ICL-inducing agent. Further provided is a method of identifying a DNA polymerase inhibitor. |
| US08715926B2 |
Biomarkers for the detection of head and neck tumors
A method of detecting the presence of specific human papilloma virus and host cell biomarkers associated with head and neck tumors in biological samples, like saliva, blood or biopsy tissue, obtained from a subject. |
| US08715925B2 |
Genetic test for the identification of carriers of complex vertebral malformations in cattle
Genetic markets for identifying bovine carriers of complex vertebral malformation (CVM) disease gene are described. The genetic markers, including the microsatellite markers, BM4129, INRAA003, BMS2790, ILSTS029, INRA123, BM220, HUJ246, BMS862, BMS937, BL1048, BMS2095 and BMS1266 and the bovine SLC35A3 gene, are located on bovine chromosome BTA3. The G/T polymorphism at position 559 of the bovine SLC35A3 gene is identified as being causative and diagnostic for CVM in cattle. |
| US08715918B2 |
Thick film resists
Thick film photoresist compositions are disclosed. |
| US08715917B2 |
Simultaneous photoresist development and neutral polymer layer formation
A photoresist layer is lithographically exposed to form lithographically exposed photoresist regions and lithographically unexposed photoresist regions. The photoresist layer is developed with a non-polar or weakly polar solvent including a dissolved neutral polymer material. A neutral polymer layer is selectively formed on physically exposed surfaces of a hard mask layer underlying the photoresist layer. The neutral polymer layer has a pattern corresponding to the complement of the area of remaining portions of the photoresist layer. The remaining portions of the photoresist layer are then removed with a polar solvent without removing the neutral polymer layer on the hard mask layer. A block copolymer material can be subsequently applied over the neutral polymer, and the neutral polymer layer can guide the alignment of a phase-separated block copolymer material in a directed self-assembly. |
| US08715912B2 |
Method for producing a high resolution resist pattern on a semiconductor wafer
In one disclosed embodiment, a method for producing a high resolution resist pattern on a semiconductor wafer comprises depositing a blanket layer of material on a semiconductor wafer, forming a resist interaction substrate on the blanket layer of material, forming a resist layer of a pre-determined thickness on the resist interaction substrate, exposing the resist layer to a patterned radiation, and developing the resulting high resolution resist pattern. In one embodiment, patterned radiation is provided by an extreme ultraviolet (EUV) light source. In other embodiments, patterned radiation may be provided by an electron beam, or ion beam, for example. In one embodiment, the resist layer comprises a chemically amplified resist utilizing a photogenerated acid (PGA), and having a sublayer. In other embodiments, the resist layer includes an additive, for example, fullerite. One disclosed embodiment involves use of an ultra-thin resist layer in combination with a gold resist interaction substrate. |
| US08715911B2 |
Coating composition for DUV filtering, method of forming photoresist pattern using the same and method of fabricating semiconductor device by using the method
Provided are a coating composition for deep ultraviolet (DUV) filtering during an extreme ultraviolet (EUV) exposure, the coating composition including about 100 parts by weight of a solvent including a first solvent (the first solvent being an alcoholic solvent); and about 0.05 parts by weight to about 5 parts by weight of a coating polymer having a degree of absorption of about 50%/μm or greater with respect to 193-nm incident light. |
| US08715910B2 |
Method for exposing an area on a substrate to a beam and photolithographic system
Embodiments of the invention describe a method for exposing an area on a substrate to a beam. The method includes adjusting a focus offset of the beam with respect to the area on the substrate, tilting the beam or tilting the substrate, and exposing the area on the substrate with the beam, thereby generating locations within the area exposed with different foci. Furthermore embodiments describe computer programs for controlling a photolithographic system to do the same and a photolithographic system for doing the same. |
| US08715909B2 |
Lithography systems and methods of manufacturing using thereof
Multi-beam lithography systems and methods of manufacturing semiconductor devices using the same are disclosed. For example, the method utilizes non-coincidence of boundaries of electrical fields emanating from chrome on glass or phase shifted mask features distributed over two masks for the optimization of lithographic process windows, side lobe suppression, or pattern orientation dependent process window optimization employing one mask with polarization rotating film on the backside. |
| US08715908B2 |
Process of using an imaging element having a photoluminescent tag
The invention relates to an imaging element and a method of using the imaging element to form a recording element. The imaging element includes a composition sensitive to actinic radiation from a source of radiation having a range of wavelengths and a photoluminescent tag that is responsive to at least one wavelength from the source of radiation. The photoluminescent tag can be used to authenticate the identity of the element, provide information about the element, and/or to establish one or more conditions in a device used to prepare the recording element from the imaging element. |
| US08715907B2 |
Developable bottom antireflective coating compositions for negative resists
A negative developable bottom antireflective coating (NDBARC) material includes a polymer containing an aliphatic alcohol moiety, an aromatic moiety, and a carboxylic acid moiety. The NDBARC composition is insoluble in a typical resist solvent such as propylene glycol methyl ether acetate (PGMEA) after coating and baking. The NDBARC material also includes a photoacid generator, and optionally a crosslinking compound. In the NDBARC material, the carboxylic acid provides the developer solubility, while the alcohol alone, the carboxylic acid alone, or their combination provides the PGMEA resistance. The NDBARC material has resistance to the resist solvent, and thus, intermixing does not occur between NDBARC and resist during resist coating over NDBARC. After exposure and bake, the lithographically exposed portions of both the negative photoresist and the NDBARC layer become insoluble in developer due to the chemically amplified crosslinking of the polymers in negative resist and NDBARC layer in the lithographically exposed portions. |
| US08715903B2 |
Actinic ray-sensitive or radiation-sensitive resin composition, and resist film and pattern forming method using the same
An actinic ray-sensitive or radiation-sensitive resin composition comprising (A) a fluorine-containing compound capable of generating an acid upon irradiation with an actinic ray or radiation, wherein the acid has a polarity converting group, and the fluorine content of the fluorine-containing compound (A) is 20% or more based on the molecular weight of the fluorine-containing compound (A). |
| US08715900B2 |
Self-imageable layer forming polymer and compositions thereof
Copolymers and compositions thereof useful for forming self-imageable films encompassing such copolymers are disclosed. Such copolymers encompass norbornene-type repeating units and maleic anhydride-type repeating units where at least some of such and maleic anhydride-type repeating units have been ring-opened. The films formed from such copolymer compositions provide self imageable, low-k, thermally stable layers for use in microelectronic and optoelectronic devices. |
| US08715888B2 |
Method for producing holographic photopolymers on polymer films
The invention relates to a method for producing novel photopolymers on the basis of prepolymer-based polyurethane compositions that are suitable for producing holographic media, in particular for the visual display of images. |
| US08715887B2 |
Complex holograms, method of making and using complex holograms
A method of making a hologram includes recording a first hologram in a holographic recording medium at a first deformation ratio; changing the first deformation ratio to a second deformation ratio that is different from the first deformation ratio; and recording a second hologram in the holographic recording medium at the second deformation ratio to form a recorded holographic medium. |
| US08715886B1 |
Method for making a fuel cell
The invention is a novel solid oxide fuel cell (SOFC) stack comprising individual bi-electrode supported fuel cells in which an electrolyte layer is supported between porous electrodes. The porous electrodes may be made from graded pore ceramic tape that has been created by the freeze cast method followed by freeze-drying. Each piece of graded pore tape later becomes a graded pore electrode scaffold that, subsequent to sintering, is made into either an anode or a cathode. The electrode scaffold comprising the anode includes a layer of liquid metal. The pores of the electrode scaffolds gradually increase in diameter as the layer extends away from the electrolyte layer. As a result of this diameter increase, any forces that would tend to pull the liquid metal away from the electrolyte are reduced while maintaining a diffusion path for the fuel. Advantageously, the fuel cell of the invention may utilize a hydrocarbon fuel without pre-processing to remove sulfur. |
| US08715880B2 |
Solid oxide fuel cell
Provided is a solid oxide fuel cell (SOFC), including: a fuel electrode for allowing a fuel gas to be reacted; an air electrode for allowing a gas containing oxygen to be reacted; an electrolyte film provided between the fuel electrode and the air electrode; and a reaction prevention film provided between the air electrode and the electrolyte film. The porosity of the reaction prevention film is less than 10%, particularly preferably “closed pore-ratio” is 50% or more. The diameter of closed pores in the reaction prevention film is 0.1 to 3 μm. The reaction prevention film includes closed pores each containing a component (e.g., Sr) for the air electrode. This can provide an SOFC in which a decrease in output due to an increase in electric resistance between an air electrode and a solid electrolyte film hardly occurs even after long-term use. |
| US08715874B2 |
Fuel cell system and method for controlling fuel cell system
A fuel cell system includes a fuel cell having an anode, a cathode, and an electrolyte membrane disposed therebetween. An oxidant gas supplying device supplies oxidant gas to the cathode, an oxidant gas backpressure regulating device regulates the pressure of the oxidant gas at the cathode according to a valve opening, and a pressure detecting device detects the oxidant gas pressure at the cathode. During a start-up fuel gas disposal process, a controller controls the oxidant gas supplying device to supply the oxidant gas at a standard oxidant gas flow, controls the valve opening of the oxidant gas backpressure regulating device to a first valve opening, and controls the valve opening of the oxidant gas backpressure regulating device to a second valve opening which is greater than the first valve opening when the oxidant gas pressure detected by the pressure detecting device reaches an elevation target pressure. |
| US08715872B2 |
Fuel cell system having decreased deterioration during initiation
A fuel cell system can be initiated in shorter time while minimizing the deterioration of a fuel cell. The fuel cell system includes a fuel cell stack having a fuel electrode, an oxidizer electrode and an electrolyte membrane disposed there between, the fuel cell producing electricity by an electrochemical reaction of a fuel gas and an oxidizer gas, which are supplied to the fuel electrode and the oxidizer electrode, respectively; a fuel gas supplying device for supplying the fuel gas to the fuel cell stack; an oxidizer gas supplying device for supplying the oxidizer gas to the fuel cell stack; a current controlling device for extracting a current from the fuel cell stack; and a voltage sensor disposed in at least two of the fuel cell stacks. A controller controls the current controlling device such that a minimum voltage, which is obtained from the voltage sensor after a fuel gas is supplied to the fuel electrode without supplying the oxidizer gas to the oxidizer electrode at the time of initiating, becomes zero volts or more. Then, the oxidizer gas is supplied to the oxidizer to start producing electricity. |
| US08715870B2 |
Gas reclaiming system and method
A gas reclaiming system is disclosed. The gas reclaiming system includes a getter device adapted to receive mixed gases and separate the mixed gases into at least one gas of interest and constituent gases. A recirculation loop is disposed in fluid communication with the getter device and adapted to receive the at least one gas of interest from the getter device. A gas reclaiming method is also disclosed. |
| US08715867B1 |
Deployable microbial fuel cell and methods
An anode/cathode system is disclosed for use in a Benthic microbial fuel cell. Carbon cloth forms at least a portion of the anode and is disposed on one side of a water oxygen impermeable layer, which can be weighted around a periphery thereof to hold the anode against a water-sediment interface. Carbon cloth flaps or strands can be attached to the other side of the impermeable layer to form the cathode. The anode and cathode can be divided into sections with each section having an electrical lead coupled thereto. The system is deployed onto the seafloor with the anode side in contact with the water-sediment interface. |
| US08715865B2 |
Non-aqueous electrolytic solutions and electrochemical cells comprising the same
Non-aqueous electrolyte solutions capable of protecting negative electrode materials such as lithium metal and carbonaceous materials in energy storage electrochemical cells (e.g., lithium metal batteries, lithium ion batteries and supercapacitors) include an electrolyte salt, a non-aqueous electrolyte solvent mixture, an unsaturated organic compound 4-methylene-1,3-dioxolan-2-one or 4,5-dimethylene-1,3-dioxolan-2-one, and other optional additives. The 1,3-dioxolan-2-ones help to form a good solid electrolyte interface on the negative electrode surface. |
| US08715857B2 |
Negative electrode active material for lithium ion battery, and negative electrode for lithium ion battery using the same
The present invention relates to a negative electrode active material including an Si—Sn—Fe—Cu based alloy, in which an Si phase has an area ratio in a range of from 35 to 80% in the entire negative electrode active material, the Si phase is dispersed in a matrix phase, the matrix phase contains an Si—Fe compound phase crystallized around the Si phase and further contains an Sn—Cu compound phase crystallized to surround the Si phase and the Si—Fe compound phase, the Si—Fe compound phase is crystallized in a ratio of from 35 to 90% in terms of an area ratio in the entire matrix phase, and the matrix phase further contains an Sn phase unavoidably crystallized in the matrix phase in a ratio of 15% or less in terms of an area ratio in the entire matrix phase. |
| US08715856B2 |
Lithium secondary battery containing cathode materials having high energy density and organic/inorganic composite porous membrane
Disclosed is a secondary battery including a cathode, an anode, a membrane and an electrolyte, wherein the cathode contains a mixture of a first cathode material defined herein and a second cathode material selected from the group consisting of a second-(a) cathode material defined herein and a second-(b) cathode material defined herein, and a combination thereof, wherein a mix ratio of the two cathode materials (first cathode material: second cathode material) is 50:50 to 90:10, and the membrane is an organic/inorganic composite porous membrane including (a) a polyolefin-based membrane substrate and (b) an active layer in which one or more areas selected from the group consisting of the surface of the substrate and a portion of pores of the substrate are coated with a mixture of inorganic particles and a binder polymer, wherein the active layer has a structure in which the inorganic particles are interconnected and fixed through a binder polymer and porous structures are formed by the interstitial volume between the inorganic particles. |
| US08715853B1 |
Aluminum batteries comprising metal-oxide, metal-fluoride, metal-sulfide, or sulfur cathodes
Variations of the invention provide an improved aluminum battery consisting of an aluminum anode, a non-aqueous electrolyte, and a cathode comprising a metal oxide, a metal fluoride, a metal sulfide, or sulfur. The cathode can be fully reduced upon battery discharge via a multiple-electron reduction reaction. In some embodiments, the cathode materials are contained within the pore volume of a porous conductive carbon scaffold. Batteries provided by the invention have high active material specific energy densities and good cycling stabilities at a variety of operating temperatures. |
| US08715852B2 |
Electrolyte for lithium secondary battery and lithium secondary battery including the same
An electrolyte for a lithium secondary battery and a lithium secondary battery including the same are provided. The electrolyte includes a non-aqueous organic solvent, lithium salt, and an additive that is either a dicarboxylic acid anhydride and a halogenated ethylene carbonate or a diglycolic acid anhydride and a halogenated ethylene carbonate. |
| US08715849B2 |
Microporous polymer membrane
The invention relates to a microporous membrane which comprises polyethylene, the microporous membrane having a differential pore volume curve with an area under the curve over the range of pore diameters of from about 100 nm to about 1,000 nm that is 25% or more of a total area under the curve over the range of pore diameters of from about 10 nm to about 1,000 nm. |
| US08715847B2 |
Lithium-sulfur battery with polysulfide confining layer
The present invention provides a lithium-sulfur battery with a polysulfide confining layer, which can prevent loss of polysulfide formed on the surface of a positive electrode during charge and discharge reactions, thus improving the durability of the battery. For this purpose, the present invention provides a lithium-sulfur battery including a hydrophilic polysulfide confining layer interposed between a positive electrode and a separator to prevent a polysulfide-based material from being lost from the surface of the positive electrode during discharge. |
| US08715840B2 |
Reduced spacing recording apparatus
Aspects include recording media with enhanced areal density through reduction of head media spacing, head keeper spacing, or head to soft underlayer spacing. Such aspects comprise replacing currently non-magnetic components of devices, such as interlayers and overcoats with components and compositions comprising magnetic materials. Other aspects relate to magnetic seed layers deposited within a recording medium. Preferably, these aspects, embodied as methods, systems and/or components thereof reduce effective magnetic spacing without sacrificing physical spacing. |
| US08715839B2 |
Electrical components and method of manufacture
An electrical component provides a ceramic element located on or in a dielectric substrate between and in contact with a pair of electrical conductors, wherein the ceramic element includes one or more metal oxides having fluctuations in metal-oxide compositional uniformity less than or equal to 1.5 mol % throughout the ceramic element. A method of fabricating an electrical component, provides or forming a ceramic element between and in contact with a pair of electrical conductors on a substrate including depositing a mixture of metalorganic precursors and causing simultaneous decomposition of the metal oxide precursors to form the ceramic element including one or more metal oxides. |
| US08715837B2 |
Black-coated steel sheet, worked material, and panel for flat-panel television
A black-coated steel sheet exhibits good bendability and a good appearance after press working is provided. Zinc based plating layers, a chromium-free chemical conversion coating disposed on the zinc based plating layer, and a colored single organic coating which is disposed on the chemical conversion coating and which contains a polyester resin having a hydroxyl value of 10 KOHmg/g or more, an imino-containing melamine resin, and 5 to 15 percent by mass of carbon black are included, wherein the glass transition temperature (Tg) of the organic coating is 40° C. or higher, the film thickness is 10 μm or less, and the hardness is 200 N/mm2 or more. |
| US08715835B2 |
Tolerance strips
A tolerance strip is formed a strip of resilient material with corrugations, the corrugations extending transversely across the full width of the strip, the corrugations defining crests with troughs between adjacent corrugations, a central portion of the corrugations being of substantially uniform height across the strip, portions of the corrugations adjacent each longitudinal edge of the strip decreasing in height towards the edge of the strip. In one form the corrugations are flat longitudinally of the strip at the crests and/or troughs. |
| US08715834B2 |
Continuous steel strapping seals
A strip of multiple seals, each seal for sealing around overlying courses of strapping material to form a seal of the strapping material onto itself at the overlying courses includes an elongated strip of ductile metal. The strip has a longitudinal direction having edges and defining a longitudinal axis parallel to the edges, and a transverse direction normal to the longitudinal axis. Each seal defines a respective transverse axis. The strip has a plurality of substantially identical slots formed in the transverse direction to define the respective seals. The slots extend toward, but not to, the edges of the strip and define connecting portions between ends of the slot and the respective edges. The slots are equally spaced from one another in a longitudinal direction to define the respective seals. |
| US08715825B2 |
Two-piece pull-tab sealing member with improved heat distribution for a container
A two-piece tabbed seal and liner as well as a method of manufacture is provided for sealing containers such as bottles, jars and the like. The two-piece tabbed seal is formed with a lower sheet-like structure having a non-foam, heat-distributing layer thereon. |
| US08715817B2 |
Glass ceramic plate
A low-expansion glass ceramic plate, in which a black coating is applied directly or indirectly to at least some areas of at least one side of the plate and the coating contains precious metal. In order to produce a glass ceramic plate of this type that is opaque, while simultaneously retaining a sufficient degree of its thermal stability, according to this invention, the precious metal content in the coating is ≧50 wt. %, the bismuth oxide content in the coating is at most 20 wt. %, and the layer thickness of the coating is at least 200 nm. |
| US08715810B2 |
Coated article and method for making the same
A coated article is described. The coated article includes a substrate, a magnesium oxide-alumina compound layer formed on the substrate, and an anti-fingerprint layer formed on the magnesium oxide-alumina compound layer. The anti-fingerprint layer is a layer of magnesium-aluminum-oxygen-fluorine having the chemical formula of MgAlOxFy, wherein 0 |
| US08715807B2 |
Fused grains of oxides comprising Al, Ti and Mg and ceramic products comprising such grains
A mixture of fused grains mainly comprising or composed of an oxide phase of pseudo-brookite type and comprising titanium, aluminum and magnesium, the fused grains having the following chemical composition, in weight percentages on the basis of the oxides: less than 55% of Al2O3; more than 30% and less than 70% of TiO2; more than 1% and less than 15% of MgO, the fused grains also corresponding to the following composition, in molar percentages and on the basis of the single oxides Al2O3, TiO2, MgO: 180≦3t+a≦220, a≦50, m=100−a−t, in which: a is the molar percentage of Al2O3; t is the molar percentage of TiO2; m is the molar percentage of MgO. A ceramic product obtained from such fused grains. |
| US08715806B2 |
Formable protector
A sandwich construction including a core having inner and outer surfaces and comprising a sheet material oriented extending between the inner and outer core surfaces in a configuration providing resistance to crushing in a direction between the inner and outer surfaces. The formable protector further includes an outer facing layer of a sheet material adhered to the outer surface of the core layer; and an inner facing layer adhered to the core inner surface and being sufficiently deformable to conform to a sharp edge of a protected object when the protector is bent therearound, and being substantially more compressible or stretchable than the outer facing layer. The core has sufficient resistance to crushing and the outer facing layer is sufficiently durable for causing the core to partially crush when the protector is bent around the sharp edge while partially retaining crushing resistance for protecting the sharp edge against impact. |
| US08715805B2 |
Optical recording medium
An object of the present invention is to provide a recordable recording medium that suppresses increase in terminal noise and does not generate a BCA signal read error. The present invention provides a recordable optical recording medium comprising a substrate as well as at least a reflection layer, recording layer and light transmission layer provided on the substrate, wherein the recording layer of said optical recording medium contains (a) an azo metal complex dye and (b) another dye whose DSC decomposition heat value is 50 cal/g to 200 cal/g and λmax in TFP solution is 250 to 400 nm. |
| US08715800B2 |
Apparatus and method to repair the junction of a sewer main line and lateral pipe
A liner assembly and method for lining a damaged pipe junction between a main and lateral pipe is provided. The liner assembly includes a main liner member and a lateral liner tube. A collar disposed near the juncture between the main liner member and lateral liner tube is impregnated with a liquid hydrophobic or hydrophilic material capable of curing in a flexible or rigid state with the material expanding in the presence of water. The hydrophobic or hydrophilic material can also be applied without the use of the collar. When the liner assembly is pressed against the main and lateral pipes, a portion of the hydrophilic or hydrophobic material is forced into the damaged pipe junction. |
| US08715799B2 |
Thermoplastic polyurethane with antistatic properties
The present invention relates to antistatic, thermoplastic polyurethane comprising ethylmethylimidazole ethyl sulfate, to a process for production of antistatic, thermoplastic polyurethane comprising ethylmethylimidazole ethyl sulfate, and to the use of ethylmethylimidazole ethyl sulfate for the production of antistatic, thermoplastic polyurethane. |
| US08715795B2 |
Molded plastic part
In a molded plastic part 1 including a body 2 constituting a design surface 2a and a reinforcing structure 3 projectingly provided on a design back surface 2b of the body 2, the body 2 and the reinforcing structure 3 being integrally molded by injection molding, the reinforcing structure 3 is formed by a combined body of a plurality of transverse ribs 7a, 7b, 7c and 7d which are arranged at appropriate intervals in the resin flow direction at the time of injection molding in the direction intersecting with the resin flow and longitudinal ribs 6p and 6q which extend at right angles to the transverse ribs and connect the transverse ribs to each other. The transverse ribs are connected to the design back surface 2b, and a gate 8 for injection molding is set on one of the transverse ribs. The longitudinal ribs are disposed so as to be separated from the design back surface 2b. |
| US08715785B2 |
Method for reinforcing hollow glass articles
The invention relates to: 1) a process for the mass production of hollow glass articles which, when positioned beside one another with the same orientation in one and the same plane, are liable to come into mutual contact along a surface of revolution, characterized in that after they have left the annealing lehr, they are rotated through one turn at least along the axis of said surface of revolution, this surface then being coated, by a process without any solid contact, with an additional layer which reduces the coefficient of friction; 2) a hollow glass article as obtained by this process; and 3) a packaging assembly of such articles. |
| US08715779B2 |
Enhanced glass impact durability through application of thin films
Apparatus, systems and methods for characteristics of glass components through use of one or more coatings are disclosed. The coatings are typically thin coatings, such as thin film coatings. The coatings can serve to increase strength of the glass components and/or provide durable user interfacing surfaces. Accordingly, glass articles that have received coatings are able to be not only thin but also sufficiently strong so as to resist damage from impact events. The coated glass articles are well suited for use in consumer products, such as consumer electronic devices (e.g., electronic devices). |
| US08715771B2 |
Coated stent and method of making the same
A coated implantable medical device and a method of coating an implantable medical device is disclosed, the method includes applying a composition onto the device and drying the composition at elevated temperature in an environment having increased relative humidity. A pre-screening method for a manufacturing lot of coated stents to determine the number of drug coating layers for a desired drug release rate is disclosed. The method including coating and testing small groups of stents, and applying the results of the tests to determine the number of drug coating layers to apply to the manufacturing lot of stents. |
| US08715770B2 |
Apparatuses and methods for microparticle dry coating of surfaces
A device for coating dry powder microparticles onto a surface may include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film. |
| US08715769B2 |
Preventing diseases in infants delivered via caesarean section
The present invention provides the use of a composition comprising non-digestible oligosaccharide for the manufacture of a composition for enteral administration to an infant delivered via caesarean section. |
| US08715765B2 |
Process of treating biomass
A process of treating biomass such as sugar cane bagasse utilizing practically all components of the biomass to produce livestock feed and fuel biomass. Raw bagasse is ensiled for 50-60 days, dried, mechanically separated from soil particles and ground together with plant-derived lignocellulosic materials, pelletized feed material, agricultural processing residues, or by-products at a ratio of 2:1. The resultant ground material is used as cattle feed, feed additives, fuel pellets and for other purposes. |
| US08715757B2 |
Systems and methods for processing eggs
A package of eggs is disclosed which comprises a plurality of eggs arranged in one or more rows. The eggs are arranged in the package so that a long axis of each egg in the package is tilted toward the back of the package so as to be at least slightly offset from vertical. In some embodiments, each of the eggs in the package may have information laser marked on it in substantially the same location as the other eggs in the package, and the eggs may be oriented in the package such that information marked on each egg faces substantially the same direction as the information marked on the other eggs in the package. |
| US08715756B2 |
Method and system for recovering and preparing glacial water
Methods and systems for grouping, recovering, and processing ice obtained from an ice source, i.e., a glacier, ice sheet, ice cap, etc., are described herein. In particular, the ice obtained from the ice source is separated and grouped according to common unique properties and processed as a beverage for consumption having the same unique properties. |
| US08715751B2 |
Artemisinins in the clinical and veterinary management of kinetoplastid infections
The invention relates to the treatment of kintoplastid infections by administering a pharmaceutical composition containing an extract from the plant Artemisia annua. The invention also relates to isolated, semi-synthetic and synthetic artemisinins that show improved efficacy in treating kinetoplastid infections. This invention also relates to a method of treating kintoplastid infections with artelinic acid and artemisinins and where Artelinic acid is administered orally. |
| US08715747B2 |
Biocomposition stimulant of the immune system, anti-tumor and anti-HIV
Provided is a herbal composition of plants obtained from non-domestic wild sources by means of meristems and the extracts thereof obtained using improved processes, in which the extracts and the active principles thereof generate a synergism demonstrating anti-inflammatory, antiviral nutritional supplement, immune system simulating, prostatic health promoting and supporting properties for improving quality of life with a wide range of benefits in individuals with chronic terminal diseases. |
| US08715745B2 |
Fungicidal compositions including hydrazone derivatives and copper
The present invention relates to the use of hydrazone compounds and copper for controlling the growth of fungi. |
| US08715738B2 |
Fullerene-silica nanoparticles with improved fluorescence, preparation method thereof and use thereof
The present invention relates to fullerene-silica nanoparticles with improved fluorescence, a preparation method of the fullerene-silica nanoparticles, and use thereof. More specifically, the present invention relates to fullerene-silica nanoparticles with improved fluorescence in which fullerene and silica are covalently linked, a preparation method of the fullerene-silica nanoparticles, and use thereof. The preparation method of the fullerene-silica nanoparticles comprises the steps of: adding a surfactant to a non-polar organic solvent and a polar solvent and stirring them to form reverse micelles (step 1); adding fullerene to the reverse micelles formed in the step 1 and stirring them (step 2); and adding a silica precursor and a catalyst to a reaction solution containing the fullerene prepared in the step 2 and stirring them to prepare fullerene-silica nanoparticles (step 3). According to the present invention, fullerene-silica nanoparticles in the form of a uniform spherical shape of tens of nanometers can be prepared. As such prepared fullerene-silica nanoparticles have a large surface area due to a nanometer-sized structure, they have good reactivity. Compared with heavy metals or metal nanoparticles, the fullerene-silica nanoparticles, because of using silica, are harmless to a living body. Further, as the fullerene-silica nanoparticles exhibit strong fluorescence, they can be used as a contrast agent for in-vivo imaging or as a drug delivery carrier. |
| US08715735B2 |
Stabilised supersaturated solids of lipophilic drugs
Methods for improving solubility and bioavailability of lipophilic compounds are described. Particularly, described are stabilized supersaturated solid solutions, particularly in power from, of lipophilic drugs, such as steroidal molecules. |
| US08715732B2 |
Nucleic acid hydrogel via rolling circle amplification
Methods and compositions are provided for producing nucleic acid-based compositions. Methods include enzyme catalyzed or nucleic acid polymer conjugation. Compositions include nucleic acid-containing hydrogels which can be elongated via rolling circle amplification. The hydrogels can encapsulate bioactive agents for drug delivery. |
| US08715729B2 |
Rapidly disintegrating, solid coated dosage form
Rapidly disintegrating, solid coated dosage form comprising a solid core consisting of at least 60% by weight of an auxiliary mixture, up to 40% by weight of at least one active ingredient, and optionally further auxiliaries, coated with at least one film coating comprising completely or partially hydrolyzed, rapidly water-soluble polyether-vinyl ester graft polymers, methods for the production thereof, and their use. |
| US08715727B2 |
Tablet for pulsed delivery
A pharmaceutical tablet comprising an immediate release portion containing an active ingredient and a delayed release portion, wherein the delayed release portion comprises an enteric-coated layer and within the enteric-coated layer there is at least one member selected from the group consisting of enteric-coated microparticle dosage forms containing an active ingredient and enteric-coated mini-tablet dosage forms containing an active ingredient, is disclosed. |
| US08715726B2 |
Pharmaceutical composition comprising tramadol and ketoprofen in association
The present invention relates to a pharmaceutical composition comprising a combination of active principles. More specifically: a stable pharmaceutical composition comprising a combination of tramadol and ketoprofen. Furthermore, a combination in solid form in which the active principles are vehicled in pharmaceutical forms and/or products that prevent contact between them. Complementarily, the present invention also relates to the combined use of ketoprofen and tramadol in the preparation of an oral medicine useful for relieving pain as well as a method for relieving pain with an oral pharmaceutical composition comprising a combination of tramadol and ketoprofen. |
| US08715725B2 |
Secure tracking of tablets
The present invention relates to a verification method for tracking and tracing tablets, particularly pharmaceutical tablets. It further relates to a visible secure marking or information that is a part of such tablet (10). The invention further relates to tablets suitable for such verification method, processes for manufacturing such tablets, and methods for reading the information. |
| US08715721B2 |
Controlled release hydrocodone
A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material. |
| US08715720B2 |
Cloud mixer and method of minimizing agglomeration of particulates
An apparatus and a method for dispersing particulate materials prone to agglomeration, in a liquid. Particulate materials are exposed to a liquid and put into that liquid to form a suspension or a dispersion in a controlled method thereby minimizing agglomerates. The method uses mechanical/hydro mixing that prevents the physical deterioration of the particulate material and inhibits agglomeration of the particles. In many cases, these materials may be nanomaterials. Almost all particulate materials can be handled in this manner. This method has been found to be especially useful for preparing solutions of exfoliated graphene and certain drugs. |
| US08715717B2 |
Composition for animal consumption
This invention is directed generally to compositions (including foods, supplements, treats, toys, etc.) for animal consumption, particularly compositions that tend to aid in weight loss or reduction in weight gain, and particularly compositions that comprise one or more medium chain fatty acid triglycerides (“MCT”). This invention also is directed generally to methods for using such compositions. This invention is further directed generally to processes for making such compositions. |
| US08715715B2 |
Dosage form for insertion into the mouth
Oral dosage forms as a biodegradable, water soluble film for delivering pharmaceutically active agents, particularly anti-migraine agents to patients through insertion into the mouth of patient and methods for administering pharmaceutically active agents to patients by insertion into the mouth to provide selective uptake of said agents through the mucosa and thus avoiding the gastrointestinal tract. |
| US08715713B2 |
Solvent cast film sustained release latanoprost implant
The present invention provides a sustained release latanoprost implant in the form of a thin film comprising latanoprost incorporated in a biodegradable polymer matrix. Preferably, said implant is an intraocular implant comprising a thin film comprising latanoprost incorporated in a biodegradable polymer matrix wherein said implant is configured as a disc or a rolled film that can be inserted into the eye and unrolls to provide a film having a high surface area to volume ratio. |
| US08715711B2 |
Long-acting injectable moxidectin formulations and novel moxidectin crystal forms
This invention provides for novel antiparasitic and pesticidal forms of moxidectin, including a long-acting polymeric implant. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections in animals. |
| US08715703B2 |
Method for the extemporaneous preparation of cosmetic compositions having the texture of a cream and compositions for carrying out said method
Disclosed is a method for the preparation of cosmetic compositions having the texture of a cream. Said preparation is made at the time when the composition is used and includes bringing into contact with each other (A) a liquid phase, (B) a powder containing a gelling agent for the liquid phase (A), and (C) an active cosmetic ingredient, whereby the elements are brought into contact by adding phase (A) to phase (B), subjecting a solid powder containing phase (B) and phase (A) in an immobilized form to mechanical stress to release phase (A). Further disclosed are compositions comprising phase (B) and phase (A) in an immobilized form (which are transformed into a cream when applied to the skin). |
| US08715698B2 |
Truncated secretory aspartyl proteinase 2
The present invention relates to an isolated truncated form of the secretory aspartyl proteinase 2, as well as to nucleic acid molecules encoding same. The present invention also relates to a composition comprising an isolated truncated form of the secretory aspartyl proteinase 2, as well as to nucleic acid molecules encoding same. |
| US08715696B2 |
Full genome DNA of human cytomegalovirus strain JHC isolated from Korean patient and open reading frames thereof
Provided are a full genome DNA of a human cytomegalovirus (HCMV) strain JHC isolated from Korean patients and open reading frames (ORFs) thereof and, more particularly, UL1, UL119 and RL6. |
| US08715695B2 |
Polypeptide fragments of the hepatitis E virus, the vaccine composition comprising said fragments and the diagnostic kits
The present invention relates to polypeptide(s) comprising the amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF 2 or its fragment, which is in the form of n-polymeric polypeptide, wherein n is an integer from 1-180; to a chimeric protein consisting of a polypeptide of the present invention and a conserved fragment of hemagglutin antigen from influenza virus; to a polypeptide of the present invention bound to a polypeptide containing epitope from hepatitis E virus ORF3 or an immunogenic fragment thereof; to a recombinant expression vector comprising the DNA molecule encoding the above polypeptides and the host cell transformed with said recombinant expression vector which is able to express polypeptide of the present invention. The present invention further relates to a vaccine composition against hepatitis E virus which comprises the above-mentioned polypeptide, or diagnostic kit for hepatitis E virus infection comprising the above-mentioned polypeptide, which includes IgG, IgM, or total antibody diagnostic kit for hepatitis E virus, and to the use of vaccine composition and diagnostic kit for prophylaxis, diagnosis and/or treatment of hepatitis E virus infection. |
| US08715694B2 |
Recombinant dengue virus antigen comprising the capsid protein leader sequence, full-length prM protein, and full-length E protein
The invention provides polypeptides and virus-like particles having, for example, an ability to induce an immune response to flaviviruses. The polypeptides can include C15, prM, and E polypeptide sequences. |
| US08715690B2 |
Circovirus sequences associated with piglet weight loss disease (PWD)
The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection is further provided. Pharmaceutical, including vaccines, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided. |
| US08715683B2 |
RANK ligand polypeptides
Described herein are cell lines and methods for preparing antibodies that bind RANKL, including cell lines that produce blocking antibodies to human RANKL. |
| US08715680B2 |
HLA peptide therapy
The invention provides polypeptides derived from a major histocompatibility complex (MHC) class I human leukocyte antigen (HLA), such as HLA-A2, and derivatives or analogues thereof. The polypeptides, derivatives and analogues can be used to treat or prevent allosensitisation, such as the treatment or prevention of allograft rejection. |
| US08715675B2 |
Vascular targets for detecting, imaging and treating neoplasia or neovasculature
Methods of delivering an agent in a tissue-specific manner, by targeting annexin A1, a derivative of annexin A1, or a binding partner of annexin A1, are described. The methods can be used for detecting, imaging and/or treating neoplasia, angiogenesis or neovasculature, as well as for diagnostics and methods of assessing treatment efficacy. Antibodies to annexin A1 are also described, as are methods screening for agents altering annexin A1 activity. |
| US08715673B2 |
Staphylococcus aureus specific antibodies and uses thereof
The present invention provides antagonizing antibodies that bind to S. aureus alpha-toxin. The invention further provides a method of obtaining such antibodies and antibody encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies for the treatment and/or prevention of staphylococcal disease, including, for example, pneumonia, bacteremia, sepsis, eye infection, and abscess. |
| US08715668B2 |
Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 and uses thereof
An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth. |
| US08715666B2 |
Method for the potentiation of opioid analgesics effects on pain
According to the invention there is provided use of an anti-TrkA antibody capable of inhibiting the binding between NGF and TrkA combined with at least one opioid analgesic for the preparation of a medicament for treating and/or preventing pain. |
| US08715664B2 |
Use of human TNFα antibodies for treatment of erosive polyarthritis
The invention describes methods of treating erosive polyarthritis comprising administering a TNFα antibody, or antigen-binding portion thereof. The invention also describes a method for testing the efficacy of a TNFα antibody, or antigen-binding portion thereof, for the treatment of erosive polyarthritis. |
| US08715663B2 |
Epitopes
Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided. |
| US08715661B2 |
Methods and compositions for increasing arylsulfatase A activity in the CNS
Provided herein are methods and compositions for treating a subject suffering from a deficiency in arylsulfatase A in the CNS. The methods include systemic administration of a bifunctional fusion antibody comprising an antibody to a human insulin receptor and an arylsulfatase A. |
| US08715654B2 |
Methods of modulating the negative chemotaxis of immune cells
The current invention is directed to methods of inducing migration of an immune cell toward a cancer cell comprising inhibiting the activity of a chemorepellant released from the cancer cell. |
| US08715652B2 |
Immunoglobulin preparations having increased stability
The present invention relates to a protein preparation having increased stability, comprising a stabiliser selected from the group consisting of non-polar and basic amino acids and having a pH of 4.0 to 5.2. The invention further relates to a pharmaceutical composition and a method of stabilising protein preparations. |
| US08715649B2 |
Compositions and methods of use for alpha-1 antitrypsin having no significant serine protease inhibitor activity
Embodiments herein illustrate methods and compositions for treating medical disorders. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating graft rejection, transplant rejection or diabetes in a subject. Other embodiments herein relate to compounds including naturally occurring and synthetic mutant compositions of alpha-1 antitrypsin, wherein the alpha-1 antitrypsin has no significant serine protease inhibitor activity. |
| US08715648B2 |
Method for treating obesity with anti-obesity formulations and omega 3 fatty acids for the reduction of body weight in cardiovascular disease patients (CVD) and diabetics
Combinations of one or more anti-obesity drugs with mixtures of an omega-3 fatty acid formulation containing about 90% or more omega 3 fatty acids by weight comprised of a combination of Eicosapentaenoic acid (EPA), Docosapentaenoic acid (DPA) and Docosahexaenoic acid (DHA) in a weight ratio of EPA:DHA of from 5.7 to 6.3, wherein the sum of the EPA, DHA and DPA comprise about 82% by weight of the total formulation and about 92% of the total omega 3 fatty acid content of the composition for the reduction of body weight in cardiovascular disease patients (CVD) and diabetics. |
| US08715647B2 |
Enzyme feed additive and animal feed including it
The use is provided composition as a feed additive which comprises one or more endoglucanases, and 0-20% by weight, based upon the content of cellulase proteins in the composition, of a cellobiohydrolase. The endoglycanases may be one or more of EGI, EGII, EGIII and any functionally active derivative of any thereof. Such endoglucanases may be obtained from a genetically modified strain of the fungus Trichoderma. Also provided is an enzyme-based feed additive which comprises EGI and/or EGII which lack the cellulose binding domain, and 0-20% by weight, based upon the content of cellulase proteins in the additive, of a cellobiohydrolase. A further enzyme-based feed additive is provided which comprises a cereal-based carrier, one or more endoglucanases, and 0-20% by weight, based upon the content of cellulase proteins in the additive, of a cellobiohydrolase. |
| US08715635B2 |
Frictionless molecular rotary motors
A rotaxane consisting of a cucurbituril and an uncharged guest molecule, having low or null affinity therebetween is provided as well as processes for providing the same. Various uses as energy converters (“frictionless” molecular motors), biochips and biosensors using the same are also provided. |
| US08715631B2 |
Cosmetic microemulsion
The present invention relates to a cosmetic microemulsion comprising a non-ionic surfactant type emulsifying agent, a co-emulsifying agent and a solvent selected from the group consisting of hexadecane and isomers thereof and dodecane and isomers thereof, said cosmetic microemulsions having particle diameter smaller than 100 nm. Preferably, this cosmetic microemulsion is used in the form of a pre-shampoo and has particles with a diameter on the order of 40 nm. |
| US08715628B1 |
Cosmetic compositions and methods for inhibiting or reducing trypsin activity
A cosmetic composition formulated for topical application to skin is provided. The composition includes a safe and effective amount of cyclohexane-1,2,3,4,5,6-hexol; a safe and effective amount of an N-acyl amino acid compound; and a dematologically acceptable vehicle. |
| US08715623B2 |
Pulmonary delivery of aminoglycoside
A dispersible powder composition comprises aminoglycoside for delivery to the lungs. The composition is effective to provide a therapeutically effective therapy via administration of less than 6 respirable unit doses by inhalation, wherein each unit dose comprises a volume of 0.30 to 0.95 mL. |
| US08715622B2 |
Echogenic polymer microcapsules and nanocapsules and methods for production and use thereof
Methods for producing echogenic polymer microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive compounds as well as targeted imaging and delivery to selected tissues and cells are provided. Compositions containing these echogenic polymer microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive agents are also provided. |
| US08715619B2 |
Compositions and methods for treating haematological proliferative disorders of myeloid origin
The disclosure relates to methods and compositions effective in the diagnosis, prognosis and treatment of human hematopoietic cancers. In particular, the disclosure provides tumor-associated genes that encode for cytokine receptors that are differentially expressed in hematopoietic tumor cells of myeloid origin compared with other cells, e.g., normal stem cells. |
| US08715618B2 |
Process for the direct synthesis of Cu containing zeolites having CHA structure
A process for the preparation of a copper containing zeolitic material having CHA framework structure and a composition comprising the molar ratio (n YO2):X203 wherein X is a trivalent element, preferably Al, Y is a tetravalent element, preferably Si, and wherein n is preferably at least 20. The process comprising the preparation of an phosphor-free aqueous solution containing at least one source for X203 and at least one source for YO2, at least one structure directing agent suitable for the preparation of a zeolitic material having CHA framework structure, and at least one Cu source, and the process further comprising the hydrothermal crystallization of said aqueous solution obtaining a suspension containing the copper containing zeolitic material having CHA framework structure. |
| US08715612B2 |
Process for preparing zinc peroxide nanoparticles
Zinc peroxide nanoparticles, used for arsenic and chromium removal, were synthesized using zinc acetate di-hydrate as precursors in ammonical water medium at room temperature. |
| US08715608B2 |
Growth of single-walled carbon nanotubes
A method for synthesizing carbon nanotubes having a narrow distribution of diameter and/or chirality is presented. The method comprises providing catalyst particles to a reactor for synthesizing the carbon nanotubes, wherein the catalyst particles are characterized by a narrow distribution of catalyst-particle diameters and a narrow distribution of catalyst-particle compositions. Preferably, the catalyst particles are characterized by a mean catalyst-particle diameter of 2.6 nm or less and a composition of NixFe1-x, wherein x is less than or equal to 0.5. |
| US08715600B1 |
Circulating dry scrubber
A circulating dry scrubber flue gas desulfurization system is disclosed. Hydrated lime is injected into the flue gas upstream of the CDS vessel. The flue gas then passes through a baghouse, where solids are captured. At least a portion of the solids are recycled. The recycle path runs from the baghouse to a splitter, where the solids are divided between the injection points. No distribution box is needed, which permits lowering the height and/or restructuring the location of many components of the system, reducing costs as well as improving or maintaining removal of combustion byproducts from the flue gas. |
| US08715599B2 |
Sorbent formulation for removal of mercury from flue gas
Methods and systems for reducing mercury emissions from fluid streams are provided herein. In embodiments, mercury is removed from flue gas streams by injecting a dry admixture of a porous mercury adsorptive material and at least one halide containing agent into the flue gas stream. |
| US08715596B2 |
Apparatus for recovering hydroprocessed hydrocarbons with two strippers in one vessel
An apparatus is disclosed for recovering hydroprocessing effluent from a hydroprocessing unit utilizing a hot stripper and a cold stripper. The cold stripper and the hot stripper are contained in the same vessel. A barrier prevents material from the hot stripper from entering into the cold stripper. |
| US08715595B2 |
Apparatus for recovering hydroprocessed hydrocarbons with two strippers in series
An apparatus is disclosed for recovering hydroprocessing effluent from a hydroprocessing unit utilizing a hot stripper and a cold stripper. A net overhead stream from the hot stripper is forwarded to the cold stripper for further stripping. The invention is particularly suitable for hydrotreating residue feed streams. The hot stripped stream may be subjected to fluid catalytic cracking. The apparatus and process eliminates the need for a fired heater in the product recovery unit. |
| US08715592B2 |
System-in-package platform for electronic-microfluidic devices
An integrated electronic-micro fluidic device an integrated electronic-micro fluidic device, comprising a semiconductor substrate on a first support, an electronic circuit on a first semiconductor-substrate side of the semiconductor substrate, and a signal interface structure to an external device. A micro fluidic structure is formed in the semiconductor substrate, and is configured to confine a fluid and to allow a flow of the fluid to and from the microfluidic structure only on a second semiconductor-substrate side that is opposite to the first semiconductor-substrate side and faces away from the first support. |
| US08715589B2 |
Sensors with thromboresistant coating
Embodiments of the present invention relate to analyte sensors comprising a heparin coating, and methods of coating analyte sensors. The heparin can be stably associated with at least a portion of a porous membrane that covers a portion of the analyte sensors. The heparin can be photochemically linked to the coating through the formation of covalent bonds. |
| US08715587B1 |
Vent booster
A vent booster is provided which includes a filter array and a fan. The vent booster is integrated into the cold air return of a home ventilation system. The filter array includes a series of filters which remove particulates and odors from the air. The integrated fan assists in forcing air through the filters. A reservoir for dispensing deodorizers or odorizers to the air is included within the vent booster. |
| US08715579B2 |
Honeycomb structure
A honeycomb structure has a substantially circular-pillar-shape. The honeycomb structure includes at least one electrically conductive honeycomb unit, a first electrode, and a second electrode. The at least one electrically conductive honeycomb unit includes walls extending along a longitudinal direction of the at least one electrically conductive honeycomb unit to define a plurality of through holes. The first electrode is provided on an outer circumferential surface of the honeycomb structure. The second electrode is provided in a vicinity of a central axis of the honeycomb structure extending along the longitudinal direction. |
| US08715578B2 |
Exhaust gas purifying apparatus
An exhaust gas purifying apparatus has a first housing including a DOC converter and DPF, and a second housing including an SCR converter, the housings disposed in parallel on the outer side of a frame such that the exhaust upstream ends thereof are positioned on the outer side in the vehicle width direction. An outlet port of the first housing and an inlet port of the second housing are communicatively connected through a communication pipe. The first housing is dividable into a first casing accommodating the DOC converter and a second casing accommodating the DPF, the two casings separably fastened by bolts. The inlet port of the first casing housing is bent inwardly in the width direction and detachably fastened to an exhaust pipe, the distal end of which opens outwardly in the width direction, through bolts. The second casing and housing are fixed to the frame through two brackets. |
| US08715576B2 |
Material, system, and method that provide indication of a breach
A multilayer material is described herein that includes at least one signaling layer configured to propagate at least one electromagnetic signal; and a flexible layer configured to enclose the at least one signaling layer, wherein the flexible layer is substantially impermeable to an environment and to the at least one electromagnetic signal. The multilayer material including the at least one signaling layer is configured to transmit a change in the at least one electromagnetic signal upon exposure of the signaling layer to the environment. A system, an article of clothing, or a method is described herein. |
| US08715573B2 |
Fluidic system for a flow cytometer with temporal processing
The fluidic system 10 of the preferred embodiment includes a sheath pump 12 to pump sheath fluid 14 from a sheath container 16 through a sample port 34 into an interrogation zone 18 and a waste pump 20 to pump the sheath fluid 14 and a sample fluid 26 as waste fluid 22 from the interrogation zone 18 into a waste container 24, and a processor 30 to calculate a time window based on the flow rate of the sample fluid 26. Preferably the processor 30 also calculates a time window for the sample fluid to reach the interrogation zone 18 from the sample port 34 based on the flow rate of the sample fluid 26. The interrogation zone 18 functions to provide a location for the fluidic system 10 and an optical analysis system 32 of the flow cytometer to cooperatively facilitate the analysis of the sample fluid 26. |
| US08715572B2 |
Method and apparatus for detection, analysis, and collection of rare cellular events
Systems and methods for the detection, analysis, and collection of rare cellular events, wherein rare cellular events are defined by events comprising less than 5% of a total number of cells in a sample. The systems and methods generally include: (1) a flow cell dimensioned so as to permit a flow of a sample through the flow cell at a flow rate greater than 300,000 cells per second; (2) a laser positioned to emit a laser beam directed to the flow cell; (3) one or more deflector components disposed between the laser and the flow cell, wherein the deflector component is configured to affect a position of the laser beam relative to the sample flow; (4) one or more fluorescence emission detectors; and (5) one or more processor configured to detect rare cellular events based on fluorescence emission from cell-binding surface markers introduced into the sample prior to the sample being flowed through the flow cell. |
| US08715571B2 |
Test strip ejector for medical device
A system and method for receiving and ejecting a test strip of a fluid testing device. The system includes parallel first and second guide rails defining a rail cavity between the guide rails. A sled includes a sled post and opposed first and second side leg sets each having at least one deflectable leg. Each of the deflectable legs is externally slidably engaged to one of the guide rails limiting the sled to only sliding motion in either a loading direction or an opposite ejection direction. An actuator arm is rotatably connected to a mechanism assembly. The sled post is received in an actuator arm slot. Actuator arm rotation in a loading rotational direction displaces the sled in the loading direction in a sliding motion. Subsequent opposite rotation of the actuator arm in an ejection rotational direction displaces the sled in the ejection direction and ejects the test strip. |
| US08715570B2 |
Device and a method for sterilization of packages
A device for sterilization of packages and a method of sterilizing packages are provided. The device comprises a gassing zone for exposing the packages to a gaseous sterilization agent, inlet mechanisms for introducing the gaseous sterilization agent into the gassing zone and a conveyor for transporting the packages through the gassing zone in a transport direction. The device also includes a separation mechanism arranged inside the gassing zone to divide at least an upper part of the gassing zone into sub gassing zones, each of said separation mechanisms having an opening for passage of the packages, each of at least a number of the inlet mechanisms being arranged to provide a flow of the gaseous sterilization agent at the opening of a respective one of the separation mechanisms. |
| US08715568B2 |
Use of compositions containing silicon for improving the corrosion resistance of vessels
Use of a composition comprising silicon, oxygen and at least one of calcium, potassium, or titanium, as a material for coating an equipment or as a constituent material of equipment, intended to be in contact with a mixture containing a chlorohydrin, hydrogen chloride and water. The use of the composition may provide a method for reducing corrosion of the equipment, for decreasing the frequency of replacement of the equipment and/or for lowering the risks linked to equipment breakage and leak. The equipment which is intended to be in contact with the mixture may be used in a process for manufacturing a chlorohydrin, in which a polyhydroxylated aliphatic hydrocarbon, an ester of a polyhydroxylated aliphatic hydrocarbon or a mixture of the two, is reacted with a chlorinating agent that contains hydrogen chloride. |
| US08715562B2 |
Method of making a container having a tethered closure
A method of making a plastic container that has a tethered closure using an extrusion blow molding process includes steps of extruding a parison, capturing the parison within a mold and inflating the parison against the mold to form a container blank having a container portion, a closure portion and a tether portion for connecting the container portion to the closure portion. The tether portion, which is preferably elongated and string like, may be formed out of flash material that is created during the molding process. The resulting container is relatively inexpensive to manufacture and facilitates the plastic recycling process. |
| US08715560B2 |
Method to control thickness in composite parts cured on closed angle tool
The present invention provides a method for controlling the thickness of composite laminates cured on closed angle tools. The invention utilizes a peel ply rather than a breather during the preparation for cure of laminate parts having a substantially uniform initial thickness. This method allows composite parts to be formed with greater uniformity and without the need for extra hardware. The composite part formed by the above method may find use in a wide variety of applications, including, for example, automotive and aerospace applications. Thus, for example, a composite part formed in accordance with the present invention is ideally suited for use as a shear tie in a commercial aircraft, which are used to secure the inner framework of the aircraft to the airplane skin. |
| US08715557B2 |
Dimensional control of concrete blocks
A concrete block mold division plate for front-face-up block molding. The division plate fits into a channel formed in each of the side walls of the mold. A plurality of fasteners secure the division plate within each channel and to the side walls of the mold. The division plate operates in conjunction with an optimized dry cast concrete mixture to provide acceptable control of the flatness and parallelism of the top and bottom surfaces of the blocks. |
| US08715555B2 |
Scaffold plank and process of making same
The invention is a plank fabricated from a composite fiberglass material. The invention further comprises the method of making the composite fiberglass plank using a pultrusion process. |
| US08715548B2 |
Mold fastening device and method of controlling the mold fastening device
A mold fastening device has a fixed die plate, a rear plate, a movable die plate that can move back and forth, a toggle mechanism, and a drive motor that drives a cross-head. The position where the cross-head should be stopped is associated with the rate at which to accelerate the cross-head from that position or the rate at which to decelerate the cross-head to that position. The cross-head is operated at an acceleration that corresponds to that position. The drive motor is thereby driven at a constant output torque, regardless of the position of the movable die plate. Further, the time for opening and closing metal molds can be shortened. |
| US08715545B2 |
Systems and methods for forming high performance compressible objects
The present systems and methods utilize a polyamic acid solution as a precursor to form a polyimide bead having desired properties. The polyamic acid solution may be formed into a polyamic acid droplet. The polyamic acid droplet is then processed to form a polyamic acid bead, such as by extraction of solvent to concentrate the polyamic acid or by partial chemical imidization of the polyamic acid. The polyamic acid bead is then better able to retain its shape during subsequent processing steps, such as drying and pressurizing, before final thermal imidization. |
| US08715541B2 |
Reusable lens molds and methods of use thereof
Described herein are devices for producing ophthalmic lenses including at least one mold half defining an optical surface where the mold half is made from a polymer that includes an aromatic polyimide, a polyphenylene, or a combination thereof. The devices exhibit numerous advantages including, but not limited to, good chemical resistance, durability, machineability, and UV absorbing properties. Also described are methods for producing ophthalmic lenses using the devices described herein. The ophthalmic lenses produced with the devices described herein exhibit excellent optical properties when compared to lenses produced from conventions molds. |
| US08715540B2 |
Aqueous and dry duel-action flame and smoke retardant and microbe inhibiting compositions, and related methods
The present invention provides combined property, dual-action aqueous and dry compositions for application to a material, such as conventional Gypsum Wall Board, ceiling tiles, joint compounds, concrete and other interior building materials, prior to an exposure of the material to fire, or prior to, during or after exposure of the material to conditions favorable to the growth of microbes, and related methods. When compositions within the present invention are properly applied to a material prior to the material being exposed to fire, or prior to, during or after the material being exposed to conditions favorable to the growth of microbes, these compositions have the effect of reducing the amount of burning that occurs to the material, and/or reducing the amount or density of smoke and associated toxic gases produced by the material, when the material is exposed to fire. These compositions also have the effect of inhibiting or reducing the growth, build-up or deposit of microbes on the material when the material is exposed to conditions favorable to the growth of microbes. |
| US08715536B2 |
Conductive material formed using light or thermal energy, method for forming the same and nano-scale composition
An electrically conductive material includes a plurality of nanowires and a plurality of nanoconnectors. The ratio by weight of the plurality of nanowires to the plurality of nanoconnectors is in a range of from 1:9 to 9:1. Nanoconnectors can be heated by thermal energy or light energy so that the nanoconnectors can be closely interconnected to each other and to nanowires, resulting in significant increase of the electrical conductivity of the electrically conductive material. |
| US08715534B2 |
Method for producing composite member of metal member and resin member
The invention discloses an injection molding method for manufacture of a metal-resin composite member; wherein the resin composition used in the method includes a plurality of metal particles having one or more metal melting points between about 200° C. and 400° C.; the resin composition is heated to a temperature higher than the resin melting point and higher than one or more metal melting points to provide a heated resin composition; and wherein injecting the heated resin into a mold results in contact of the heated resin with one or more disposed heated metal member(s) to provide a composite member. |
| US08715527B2 |
Liquid-crystal medium
The invention relates to a liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, characterized in that it comprises one or more compounds of the formula I and one or more compounds selected from the compounds of the formulae IA and IB in which R1, R2, L1-4, X1 and X2 have the meanings indicated in claim 1. |
| US08715524B2 |
Polishing liquid
The invention provides a polishing liquid for polishing a barrier layer of a semiconductor integrated circuit, the polishing liquid comprising: a diquaternary ammonium cation; a corrosion inhibiting agent; and a colloidal silica, wherein the pH of the polishing liquid is in the range of 2.5 to 5.0. According to the invention, a polishing liquid capable of achieving a superior barrier layer polishing rate, as well as suppressing the occurrence of scratching due to the agglomeration of solid abrasive grains can be provided. |
| US08715523B2 |
Heat storage material and heat utilization system using the same
There is provided a heat storage material capable of recovering/storing thermal energy such as exhaust heat energy or sunlight, and a heat utilization system using the same. The heat storage material of the present invention comprises a complex compound of the formula (I), wherein, R, R′, A, B, C, D, A′, B′, C′ and D′ are as defined herein. |
| US08715522B2 |
Refrigerator oil composition
A refrigerator oil composition contains base oil and polyalkylene glycol (PAG) block copolymer. The PAG block polymer is represented by the following formula (1). R1[(OR2)m(OE)nOR3]1 (1) In the formula: R1 represents a hydrocarbon residue having 1 to 10 carbon atoms; R2 represents an alkenyl group having 3 to 6 carbon atoms; E represents an ethylene group; R3 represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms; m and n each represent a positive integer, a ratio of m to n (m/n) being 99/1 to 50/50; and l represents an integer in a range of 1 to 100. |
| US08715519B2 |
Plasma reactor with adjustable plasma electrodes and associated methods
Plasma reactors with adjustable plasma electrodes and associated methods of operation are disclosed herein. The plasma reactors can include a chamber, a workpiece support for holding a microfeature workpiece, and a plasma electrode in the chamber and spaced apart from the workpiece support. The plasma electrode has a first portion and a second portion configured to move relative to the first portion. The first and second portions are configured to electrically generate a plasma between the workpiece support and the plasma electrode. |
| US08715517B2 |
Process for fabricating an acoustic wave resonator comprising a suspended membrane
A process for fabricating an acoustic wave resonator comprising a suspended membrane comprising a piezoelectric material layer, comprises the following steps: production of a first stack comprising at least one layer of first piezoelectric material on the surface of a first substrate; production of a second stack comprising at least one second substrate; production of at least one non-bonding initiating zone by deposition or creation of particles of controlled sizes leaving the surface of one of said stacks endowed locally with projecting nanostructures before a subsequent bonding step; direct bonding of said two stacks creating a blister between the stacks, due to the presence of the non-bonding initiating zone; and, thinning of the first stack to eliminate at least the first substrate. |
| US08715515B2 |
Process for optimization of island to trench ratio in patterned media
A sequence of process steps having balanced process times are implemented in sequence of etch chambers coupled linearly and isolated one from the other, resulting in the optimization of island to trench ratio for a patterned media. A biased chemical etching using active etching gas is used to descum and trim the resist patterns. An inert gas sputter etch is performed on the magnetic layers, resulting in the patterned magnetic layer on the disk. A final step of stripping is then performed to remove the residual capping resist and carbon hard mask on top of un-etched magnetic islands. The effective magnetic material remaining on the disk surface can be optimized by adjusting the conditions of chemical etch and sputter etch conditions. Relevant process conditions that may be adjusted include: pressure, bias, time, and the type of gas in each step. |
| US08715514B2 |
Micro-electromechanical systems (MEMS) microphone and method of manufacturing the same
Provided are a micro-electromechanical systems (MEMS) microphone and a method of manufacturing the same. A manufacturing process is simplified compared to a conventional art using both upper and lower substrate processes. Since defects which may occur during manufacturing are reduced due to the simplified manufacturing process, the manufacturing throughput is improved, and since durability of the MEMS microphone is improved, system stability against the external environment is improved. |
| US08715510B2 |
Methods and devices for measuring the concentration of an additive
An apparatus and methods for measuring the concentration of an additive are disclosed. The apparatus comprises a treatment stream (1) and a dosing stream (2). An additive is added to the dosing stream using a metering device (3). In some embodiments, the dosing stream is mixed after adding the additive using a first mixing device (4). Downstream from the metering device and the mixing device, the concentration of the additive in the dosing stream is measured using a monitor flow cell (5). In some embodiments, the dosing stream and treatment stream are combined (6) and mixed using a second mixing device (7). The concentration of the additive in the treatment stream can be calculated as a function of the volumetric flow rate ratio of the dosing stream to the treatment stream and the measured concentration of the additive in the dosing stream. |
| US08715507B2 |
Storm drain baffle to decrease sediment washout
Some examples includes a flow-through stormwater sump having a bottom and defining an inlet opening, an outlet opening and a top access opening, an inlet conduit coupled to the flow-through stormwater sump at the inlet opening, an outlet conduit coupled to the flow-through stormwater sump at the outlet opening and a flow-path baffle disposed in the stormwater sump, the flow-path baffle being substantially planar and defining a plurality of openings, the flow-path baffle oriented such that a centerline of the inlet conduit intersects a major plane of the baffle at a point and a centerline of the outlet conduit intersects the major plane at a further point, the flow-path baffle disposed in the stormwater sump in a direct impingement inlet flow-path of the inlet conduit and a direct impingement outlet back-flow-path of the outlet conduit. |
| US08715503B2 |
Method for the remediation of salt-containing wastewater streams
In some embodiments, a wastewater treatment system may reduce contaminants in water. A system may include one or more bioreactors which include a substrate that supports a biofilm. The bacteria used to form the biofilm may be selected to maximize the reduction of contaminants in water. Various components of the wastewater treatment system may be optimized to improve the efficiency and energy consumption of the wastewater system. |
| US08715496B2 |
Water alteration structure and system having below surface valves or wave reflectors
A system for altering water properties in an outdoor body of water includes a holding vessel configured to hold water. The holding vessel has at least one wall extending above a mean surface water level. The system also includes at least one conduit extending downward from the holding vessel. The at least one conduit has a length extending to a depth at which at least one property of water at the depth differs substantially from that of water at the surface. The system further includes at least one aperture formed in at least one of the holding vessel or the at least one conduit and located at a distance below the mean surface water level. Further still, the system includes at least one one way valve coupled to the at least one aperture and allowing flow of water in only one direction. |
| US08715494B2 |
Device for separating ferromagnetic particles from a suspension
A device for separating ferromagnetic particles from a suspension may include a tubular reactor through which the suspension can flow and which has an inlet and an outlet, and a means for generating a magnetic field, which means is designed to generate a magnetic travelling field which acts on the reactor. |
| US08715493B2 |
Filter arrangement for filtering liquids
A filter arrangement for filtering liquids has a central tube and a first filter element flowed through in radial direction outwardly and disposed on the central tube. A downstream second filter element is disposed on the central tube and flowed through in radial direction inwardly. The first filter element is moveable along the central tube from a basic position into an extended position. In the basic position a connection between the inlet line and a clean side of the first filter element is provided by the first filter element. In the extended position a bypass between an inlet line and the clean side of the first filter element is provided to bypass the first filter element. A spring element, applying a restoring force in a direction of extension of the central tube, is arranged on the first filter element at a side facing away from the second filter element. |
| US08715486B2 |
Process for producing a hydrocarbon component
The invention relates to a process for producing a new type of high-quality hydrocarbon base oil of biological origin. The process of the invention comprises ketonization, hydrodeoxygenation, and isomerization steps. Fatty acids and/or fatty acid esters based on a biological raw material are preferably used as the feedstock. |
| US08715484B2 |
Process for producing needle coke for graphite electrode and stock oil composition for use in the process
The invention provides a stock oil composition for needle coke for a graphite electrode, the stock oil composition having a 10 vol % distillation temperature of 280° C. or higher as the distillation property, and when separated into the aromatic component and non-aromatic component by elution chromatography, having an aromatic component content of 30-80 wt % with respect to the total weight of the stock oil composition and an aromatic component molecular weight of 255-1300, as well as a non-aromatic component normal paraffin content of at least 5 parts by weight with respect to 100 parts by weight of the aromatic component. |
| US08715483B1 |
Process for the recovery of lead from lead-bearing materials
A system for recovering lead from lead-bearing materials by circulating an aqueous solution of ferric fluoroborate in fluoroboric acid through a leaching vessel to leach lead from the lead-bearing material and an electrolytic cell for recovering the lead includes a cooler for cooling at least a portion of the circulating solution sufficiently to precipitate alkali salts and alkali-earth salts, and a filter for removing the precipitated salts from the solution. A process for recovering lead from lead-bearing materials by leaching the lead from the lead-bearing material with a solution of ferric fluoroborate in fluoroboric acid and recovering the lead from the solution includes cooling at least a portion of the circulating solution sufficiently to precipitate alkali salts and alkali-earth salts, and filtering the salts from the solution. |
| US08715477B2 |
Apparatus and process for separation and selective recomposition of ions
A device and process are disclosed for the separate removal of oppositely charged ions from electrolyte solutions and recombining them to form new chemical compositions. The invention provides the ability to create multiple ion flow channels and then form new chemical compositions therefrom. The process is accomplished by selectively combining oppositely charged ions of choice from different electrolyte solutions via the capacitive behavior of high electrical capacity electrodes confined in insulated containers. |
| US08715473B2 |
Method for determining ion concentration or concentration of a substance in a solution
Method for determining ion concentration or concentration of a substance in a solution by means of an ion selective, field effect transistor or an ion sensitive sensor having an EIS structure. The method comprises steps as follows: at least at a predetermined point in time of a first measuring phase, the potential lying on the electrode is sensed relative to a reference potential; before beginning a sterilization- and/or cleaning phase following the first measuring phase, the last voltage sensed during the first measuring phase is stored; and at the beginning of a second measuring phase following the sterilization- and/or cleaning phase, is the voltage stored during the sterilization phase is applied on the electrode. |
| US08715468B2 |
Machine and method for machining a part by micro-electrical discharge machining
The invention relates to a machine for machining a part by micro-electrical discharge machining, said machine comprising a mechanism (44, 45, 46, 48) for modifying the configuration of the machine so as to alternatively and reversibly switch from a machining configuration to a sharpening configuration in which the tip of a same etching electrode (20) and another electrode (64) are dipped in an electrolyte bath in order to sharpen the tip of the etching electrode by electrochemnical corrosion. |
| US08715466B1 |
Method and system for reducing water loss in a paper mill
A method and system for reducing waste water from a paper machine system. The system involves splitting a flow output from a seal water tank. With a portion of the flow output being used to maintain a fluid level within a wire pit, and the balance being recycled to the system as substantially clean water. |
| US08715465B2 |
Paper making process using binder/filler agglomerates
A process for making paper, comprising contacting an anionic binder with a cationizing agent to make a cationized binder, contacting the cationized binder with an anionic pigment to form a binder/pigment agglomerate, contacting the agglomerate with an aqueous slurry of fibers, and forming a paper product from the slurry. The agglomerate may reduce the total cost of the paper product being produced while maintaining the strength of the paper at acceptable levels. |
| US08715462B2 |
Process and apparatus for recycling coated paper products
Methods and apparatus are provided for exploiting coated paper products such as coated paper cups. End products include biofuels that have a high energy density. The biofuels may be mixed with coal or other fuels and have good binding characteristics. In some embodiments, useful chemicals such as HMF are produced. The methods involve heat treatment at relatively mild temperatures and pressures under acidic conditions. |
| US08715458B2 |
Adjustable micro device feeder system and method of operation thereof
A method of operation of a micro device feeder system includes: adjusting a distance between a movable drive plate and a mounting plate for aligning a carrier tape carrying a micro device to a center line for pick-up of the micro device by external device handling equipment; and configuring a tape handling mechanism, having a sprocket assembly, to accommodate a predetermined width of the carrier tape. |
| US08715455B2 |
Multi-zone gas distribution system for a treatment system
A treatment system is described for exposing a substrate to various processes. Additionally, a gas distribution system is configured to be coupled to and utilized with the treatment system in order to distribute process material above the substrate is provided. The treatment system includes a process chamber, a radical generation system coupled to the process chamber, a gas distribution system coupled to the radical generation system and configured to distribute reactive radicals above a substrate, and a temperature controlled pedestal coupled to the vacuum chamber and configured to support the substrate. The gas distribution system is configured to efficiently transport radicals to the substrate and distribute the radicals above the substrate. |
| US08715448B2 |
Method for producing laminate for configuring image display device, and image display device using the same
A method for producing a laminate for configuring an image display device is provided, capable of realizing simultaneously unevenness followability and anti-bubble reliability. A method for producing a laminate for configuring an image display device is proposed, comprising the following steps (1) and (2): (1) The step of forming an adhesive composition into the form of a monolayer or a multilayer sheet, and by UV-crosslinking, primary-curing this thereby forming a pre-secondary curing transparent double-sided adhesive sheet. (2) The step of layering two image display device-constituting members via the pre-secondary curing transparent double-sided adhesive sheet and then irradiating ultraviolet light from at least a first image display device-constituting member side, UV-crosslinking through this member and secondary-curing the pre-secondary curing transparent double-sided adhesive sheet. |
| US08715446B2 |
Latent solvent-based microfluidic apparatus, methods, and applications
A latent solvent-based microfluidic apparatus and method involves laminate bonding of two non-elastomeric, cyclic olefin copolymer (COC) components having opposing surfaces to be bonded, wherein in a contacted state there is at least one interstitial space between the contacted surfaces, applying an organic latent solvent to at least one of the opposing surfaces, wherein the latent solvent is in an inactive state, contacting the two opposing surfaces together, actively removing the latent solvent from the at least one interstitial space; and adjusting a latent solvency parameter to activate the latent solvent, wherein the opposing contacted surfaces become bonded. |
| US08715445B2 |
Method for manufacturing liquid crystal display element
A method for manufacturing a liquid crystal display element, includes: providing a long sheet material including a laminate of an optical film containing a polarizer, a pressure-sensitive adhesive layer, and a carrier film temporarily bonded to the pressure-sensitive adhesive layer; cutting the long sheet material at predetermined intervals, while maintaining the continuity of the carrier film; peeling off the carrier film by a tensile force; and continuously bonding the resulting optical film pieces to liquid crystal panels, respectively, through the pressure-sensitive adhesive layer exposed by the peeling off, while feeding the resulting optical film pieces, wherein the cutting is performed to such a depth as to substantially reach the carrier film, and the carrier film is cut to a depth less than half of the thickness of the carrier film at least both end portions in the width direction of the carrier film. |
| US08715442B2 |
Lateral pipe lining material and lateral pipe lining method
A tubular lateral pipe lining material is configured to be inserted into a lateral pipe which intersects with a main pipe in order to repair the lateral pipe. The tubular lateral pipe lining material has a flexible tubular resin-absorbing material impregnated with an uncured curable liquid resin. The tubular resin-absorbing material has one end that is folded back. A flange member, over which the folded-back end of the tubular resin-absorbing material is pressed, is made of a thermoplastic resin. An adhesive is applied over the flange member and the folded-back end of the tubular-absorbing material to bond the tubular resin-absorbing material to the flange member. |
| US08715441B2 |
Medical tubing having variable characteristics and method of making same
The invention primarily is directed to a medical tubing adapted for insertion into a body tissue or cavity and method of manufacturing different variations of the tubing along a length of the tubing. The tubing comprises a plurality of individual, discrete, generally ring-shaped elements arranged in series and fused or bonded together forming a continuous tubular structure. The ring-shaped elements may include a combination of flexible and rigid ring-shaped elements assembled along different portions or sections of the tubular structure. In another aspect of the invention, the medical tubing may further comprise a secondary lumen and a pull wire to control the tubular structure. In another aspect of the invention, the ring-shaped elements may vary in diameter and/or composition in different portions or sections of the tubular structure. |
| US08715437B2 |
Composite foam product
A composite foam product comprising a foam core surrounded by a gas-impermeable film. The gas-impermeable film retains the gas formed from the blowing agent so that the pressure inside the foam core is above ambient pressures. |
| US08715435B2 |
Method for modifying composite articles
In certain embodiments of the present disclosure a method for modifying a composite article is described. The method includes positioning a plug made from composite material at a site on the composite article. The method further includes rotating at least one of the plug and the article at a rate of speed sufficient to form an inertia bond between the plug and the site of the composite article. The plug and the site are engaged to effect an inertia bond therebetween. |
| US08715431B2 |
Copper alloy plate for electric and electronic parts having bending workability
A Cu—Fe—P copper alloy sheet which has the high strength and the high electrical conductivity compatible with excellent bendability is provided. The Cu—Fe—P copper alloy sheet contains 0.01% to 3.0% of Fe and 0.01% to 0.3% of P on a percent by mass basis, wherein the orientation density of the Brass orientation is 20 or less and the sum of the orientation densities of the Brass orientation, the S orientation, and the Copper orientation is 10 or more and 50 or less in the microstructure of the copper alloy sheet. |
| US08715429B2 |
Non-heat treated rolled steel and drawn wire rod with excellent toughness, and method for manufacturing the same
There is provided a rolled steel with excellent toughness, a drawn wire rod prepared by drawing the rolled steel, and a method for manufacturing the same, in which even if a heating step is omitted, the toughness of the steel can be improved by securing a degenerated pearlite structure in an internal structure of the rolled steel by controlling a content of Mn among components and cooling conditions, and then preventing C diffusion. The rolled steel according to the present invention includes C: 0.15˜0.30%, Si: 0.1˜0.2%, Mn: 1.8˜3.0%, P: 0.035% or less, S: 0.040% or less, the remainder Fe, and other inevitable impurites, as a percentage of weight, in which the microstucture of the rolled steel is composed of ferrite and pearlite including cementite with 150 nm or less of thickness. |
| US08715428B2 |
Hot-forging micro-alloyed steel and hot-rolled steel excellent in fracture-splitability and machinability, and component made of hot-forged microalloyed steel
The invention provides a hot-forging micro-alloyed steel and a hot-rolled steel which achieve excellent fracture-splitability and machinability, without impairing productivity or mechanical properties and without addition of Pb or the like. It also provides a component made of hot-forged micro-alloyed steel. The hot-forging micro-alloyed steel contains, in mass %, C: greater than 0.35 to 0.60%, Si: 0.50 to 2.50%, Mn: 0.20 to 2.00%, P: 0.010 to 0.150%, S: 0.040 to 0.150%, V: 0.10 to 0.50%, Zr: 0.0005 to 0.0050%, Ca: 0.0005 to 0.0050% and N: 0.0069 to 0.0200%, Al being limited to less than 0.010%, and a balance of Fe and unavoidable impurities. |
| US08715426B2 |
Food preparation assemblies and related methods
A food preparation assembly for use in cleaning food products generally includes a tank for holding washing fluid for use in cleaning food products positioned within the tank, and a pump in fluidic communication with the tank to provide movement of the washing fluid within the tank for use in cleaning the food products when positioned within the tank. A processing module is configured to receive settings from a user for cleaning the food products, and to monitor and adjust, as necessary, parameters of the washing fluid based on the user input settings. The processing module is also configured to report and/or store measured values of the parameters of the washing fluid in addition to select user defined input information (e.g., user defined wash settings, etc.). Labels may also be generated indicative of completion of cleaning of the food products by the food preparation assembly. |
| US08715423B2 |
Pipeline pig with internal flow cavity
A pig for movement within a pipeline comprising a cylindrical housing with annular seals circumferentially mounted to the housing and extending outwards for sealing engagement between the pipeline and the housing. An internal flow cavity passes through the housing, with a gate positioned within the internal flow cavity, initially obstructing flow through the cavity. A locking device, connected to the gate, prevents the gate opening. A sensing device is capable of receiving a signal and is connected to an unlocking device. The sensing device receives a signal activating the unlocking device, thereby removing the locking device, permitting the gate to open and flow to pass through the cavity. |
| US08715421B2 |
Wiper with scrubber assembly that is raised and lowered
A windshield wiper includes a wiper assembly, a scrubber assembly, and an engaging assembly. The wiper assembly includes a wiper support structure and a wiper blade attached to the wiper support structure. The scrubber assembly includes a scrubber support structure, an elongated scrubber element and a motor. The scrubber element is movably attached to the scrubber support structure and extends between a first end and a spaced apart second end along a central longitudinal axis. The motor is mounted to the scrubber support structure and is engaged with the scrubber element to reciprocally move the scrubber element along the central longitudinal axis. The engaging assembly is coupled with the wiper assembly and the scrubber assembly and is configured to raise and lower the scrubber assembly with respect to the wiper assembly. Also, an automated method of using a windshield wiper. |
| US08715420B2 |
Method for supplying hydroxyl radical-containing water and apparatus for supplying hydroxyl radical-containing water
Disclosed is a method for supplying hydroxyl radical-containing water, which is highly convenient and with which water containing a relatively high concentration of hydroxyl radicals can be supplied to the point of use. The method for supplying hydroxyl radical-containing water comprises a production step of producing hydroxyl radical-containing water by dissolving ozone, hydrogen peroxide, and at least one additive substance selected from a group consisting of a water-soluble organic compound, an inorganic acid, a salt of an inorganic acid, and hydrazine in pure water, a transferring step of transferring the produced hydroxyl radical-containing water to the point of use, and a supplying step of supplying the hydroxyl radical-containing water to the point of use after transferring. |
| US08715418B2 |
Semiconductor processing system; a semiconductor processing chamber; and a method for loading, unloading and exchanging semiconductor work pieces from a semiconductor processing chamber
A semiconductor processing system and related methodology is disclosed and which includes a processing chamber having an internal cavity and a transfer port; a transfer chamber which is positioned adjacent to the processing chamber; and a transfer apparatus having at least two extendible arms which are positioned within the transfer chamber, and wherein each of the extendible arms carry a semiconductor work piece into and out of the processing chamber by way of the transfer port, and wherein the at least two extendible arms are selectively vertically moveable, and further are each selectively moveable in the direction of the transfer port. |
| US08715416B2 |
Doping apparatus for simultaneously injecting two dopants into a semiconductor melt at different positions and method for manufacturing silicon single crystal using the doping apparatus
A doping device includes a first dopant accommodating portion including an opening on an upper portion to accommodate a first dopant that is evaporated near a surface of a semiconductor melt; a second dopant accommodating portion including a dopant holder that holds a second dopant that is liquefied near the surface of the semiconductor melt while including a communicating hole for delivering the liquefied dopant downwardly, and a conduit tube provided on a lower portion of the dopant holder for delivering the liquefied dopant flowed from the communicating hole to the surface of the semiconductor melt; and a guide provided by a cylinder body of which a lower end is opened and an upper end is closed for guiding dopant gas generated by evaporation of the first dopant to the surface of the semiconductor melt. |
| US08715413B2 |
Method for manufacturing a group III nitride semiconductor crystal and method for manufacturing a group III nitride semiconductor substrate
The invention provides a method for manufacturing a Group III nitride semiconductor crystal. The method includes the steps of preparing a seed crystal and performing a convex surface-growing step to grow the group III nitride semiconductor crystal. The growth surface of the group III nitride semiconductor crystal is constituted only by a plurality of surfaces not vertical to a growth direction and the group III nitride semiconductor crystal grows while forming a convex shape as a whole by the growth surface constituted of the plurality of surfaces. The invention also provides a method for manufacturing a group III nitride semiconductor substrate. |
| US08715410B2 |
Strontium-apatite cement preparation cements formed therefrom, and use thereof
Calcium-strontium-hydroxyphosphate (strontium-apatite-) cement preparations are described, comprising a powder mixture, which contains molar quantities of the components calcium (Ca), strontium (Sr) and phosphate (P) in the mixture in the ranges 1.00 |
| US08715406B2 |
UV absorbers soluble in polar media
The invention relates to triazine-based special organic UV absorbers modified in such a way as to be soluble in polar coating compositions. The invention further relates to coatings, e.g. sol-gel based ones, containing said novel UV absorbers as well as to the use of said coatings for permanently protecting materials, especially plastics, from photochemical degradation. |
| US08715403B2 |
Multi-stage pre-treatment method for metal components having zinc and iron surfaces
The invention relates to an acidic, aqueous, chromium-free composition (A) for the anti-corrosive treatment of steel and/or galvanized steel surfaces comprising metal ions (M) selected from ions at least of the elements nickel, cobalt, molybdenum, iron or tin and a multi-stage method applying the composition (A) for the anti-corrosive pre-treatment of metal components which have steel and/or galvanized steel surfaces. The invention further relates to metal surfaces of zinc or iron having a passive layer system comprising at least 30 mg/m2 nickel and at least 10 mg/m2 zircon, titanium and/or hafnium and sulfur, wherein nickel is present in metallic form at up to at least 30 At. %, obtainable in a method according to the invention. |
| US08715402B2 |
Air pollution control system and air pollution control method, spray drying device of dewatering filtration fluid from desulfurization discharged water, and method thereof
To include a boiler 11 that burns fuel F, an air heater 13 that recovers heat of flue gas 18 from the boiler 11, a first precipitator 14 that reduces dust in the flue gas 18 after heat recovery, a desulfurizer 15 that reduces sulfur oxides in the flue gas 18 after dust reduction by an absorbent, a dewaterer 32 that reduces gypsum 31 from desulfurization discharged water 30 discharged from the desulfurizer 15, a spray drying device 34 including an atomizer that atomizes a dewatering filtration fluid 33 discharged from the dewaterer 32, and a flue-gas introducing line L11 that introduces a part of the flue gas 18 into the spray drying device 34. |
| US08715398B2 |
Method and device for purifying fluids
An apparatus for the purification of fluids includes a material exchange apparatus which contains a more volatile fluid and a less volatile fluid. The material exchange apparatus contains a structured packing, with the structured packing containing a first packing layer (10) and a second packing layer (100). The first packing layer (10) and the second packing layer (100) have corrugations, with open channels (12, 14, 16, 112, 114, 116) being formed by the corrugations. The channels (12, 14, 16) of the first packing layer (10) cross the channels (112, 114,116) of the second packing layer, wherein the channels (12, 14, 16, 112, 114, 116) can be flowed through by the less volatile fluid so that the channel is wettable by the less volatile fluid, wherein a film of the less volatile fluid is formed on the surface of the channel, so that a purification can be carried out either of the more volatile fluid or of the less volatile fluid by a material exchange between the more volatile fluid and the less volatile fluid. The first packing layer (10) is in touching contact with the second packing layer (100) via spacer elements (24, 34, 44, 134, 144). |
| US08715397B2 |
Mixed amine and non-nucleophilic base CO2 scrubbing process for improved adsorption at increased temperatures
A CO2 amine scrubbing process uses an absorbent mixture combination of an amine CO2 sorbent in combination with a non-nucleophilic, relatively stronger, typically nitrogenous, base. The weaker base(s) are nucleophilic and have the ability to react directly with the CO2 in the gas stream while the relatively stronger bases act as non-nucleophilic promoters for the reaction between the CO2 and the weaker base. The sorption and desorption temperatures can be varied by selection of the amine/base combination, permitting effective sorption temperatures of 70 to 90° C., favorable to scrubbing flue gas. |
| US08715394B2 |
Autothermal cycle for CO2 capture
Provided herein are methods and apparatus for capturing or otherwise decreasing the amount of CO2 in an exhaust stream. The separation process for removing CO2 from a waste stream preferably operates substantially at atmospheric pressure and at a preselected temperature, and without the need of thermal swing regeneration. This novel elimination of the heat up and cool down periods allows the inventive cycle herein to be run faster, and more efficiently than in previously known systems. Further, in some examples herein, the heat of adsorption is used to provide the heat of regeneration. |
| US08715386B2 |
Process for preparing metal powders having low oxygen content, powders so-produced and uses thereof
In various embodiments, low-oxygen metal powder is produced by heating a metal powder to a temperature at which an oxide of the metal powder becomes thermodynamically unstable and applying a pressure to volatilize the oxygen. |
| US08715379B2 |
Advanced ASU and HRSG integration for improved integrated gasification combined cycle efficiency
A system and method for increasing the efficiency and/or power produced by an integrated gasification combined cycle system by increasing the integration between the air separation unit island, the heat recovery steam generator and the remainder of the system. By integrating heat produced by the heat recovery steam generator in the remainder of the integrated gasification combined cycle system, heat may be utilized that may have otherwise been lost or used further downstream in the system. The integration helps to increase the efficiency of the combustion reaction and/or the gasification reaction used to produce the syngas utilized in the integrated gasification combined cycle system. |
| US08715377B2 |
Stable suspensions of biomass comprising inorganic particulates
Liquid suspensions are disclosed comprising a suspending medium, small particles of biomass, and small particles of an inorganic material. The inorganic material stabilizes the suspension, so that it may be transported by pipeline or tank car without developing a sediment.The suspension may be used in manufacturing a bio-fuel. |
| US08715373B2 |
Fuel composition comprising a nitrogen-containing compound
A fuel additive concentrate comprising at least one aryl amine; and at least one metal-containing compound is disclosed. In an aspect, the fuel additive concentrate can be synergistic. Fuel composition comprising the fuel additive concentration and methods of combusting the fuel composition are also disclosed. Moreover, methods of enhancing research octane number, increasing fuel economy, and reducing the carbon footprint of a vehicle are also disclosed. |
| US08715372B2 |
Diesel cycle fuel compositions containing dianhydrohexitols and related products
Diesel cycle fuel compositions are described containing at least one dianhydrohexitol compound according to the general formula 2 and/or its derived hydrocarbyl ethers or nitric ethers compounds, where the R′ and R″ substituents are both H or one or both of R′ and R″ is alkyl, cycloalkyl or phenyl, or one or both are —NO2. A preferred fuel composition is that containing dimethyl isosorbide (DMI) added or not of isosorbide dinitrate (ISDN) as ignition improver. The dianhydrohexitols compounds form compositions with at least one of the components selected among petroleum-derived diesel fuel, biodiesel, ethanol and water. The mixture of DMI and ISDN has excellent cetane number (IQT). Still, the oxygenated nature of the dianhydrohexitols and related compounds of the fuel compositions inhibits soot formation upon burning of the said Diesel cycle fuel compositions. |
| US08715366B2 |
Porous and nonporous materials for tissue grafting and repair
Implants having improved mechanical properties and/or degradation profiles, kits including such implants, and methods of producing and using the same. |
| US08715362B2 |
Ankle replacement system
A prosthesis suited for orthopedic implantation possesses a multi-piece stem component that supports an artificial joint surface that can articulate with another artificial joint surface in various ways. The prosthesis can be assembled in a snap fit and/or interlocking fashion that provides positive locking means without the use of screws or other fasteners. The prosthesis can accommodate fitment of a plastic joint surface made, e.g., from ultra high molecular weight polyethylene. The prosthesis is well suited for use in an ankle replacement system that can be installed using minimally invasive intramedullary guidance established with respect to the major axis of the tibia by minimally invasive access through the calcaneus, through an incision in the bottom of the foot. The prosthesis makes possible the installation of a total ankle system using minimally invasive anterior access to the ankle joint for making bony cuts and to install prosthesis components. |
| US08715360B2 |
Systems and methods for providing an asymmetrical tibial component
Systems and methods for providing deeper knee flexion capabilities. In some instances, such systems and methods include a tibial component that has an asymmetrical articular plateau that includes a medial tibial condylar surface and a lateral tibial condylar surface. In some cases, at least one of the medial condylar surface and the lateral condylar surface includes a concave articulation surface having a lowest point that disposed from a posterior edge of the tibial component by between about 18% and less than about 35% of a total anteroposterior dimension of the tibial component. Other implementations are also discussed. |
| US08715357B2 |
Systems and methods for providing a modular femoral component
Systems and methods for providing deeper knee flexion capabilities. In some instances, such systems and methods include a modular component, wherein the modular component is configured to attach to a femoral component, and wherein the femoral component is configured to attach to a distal portion of a femur. In some cases, the modular component includes an articular surface that is configured to increase a surface area of an articulation surface of a proximal portion of a posterior condyle of the femoral component. Other implementations are also discussed. |
| US08715356B2 |
Prosthetic having a modular soft tissue fixation mechanism
A method and apparatus for coupling soft tissue to a prosthetic is disclosed. Soft tissue attachment pads having porous metal attachment regions and suture accepting holes are selectively positioned onto an implantable prosthetic to provide coupling locations. |
| US08715351B1 |
Expandable interbody fusion device with graft chambers
An expandable interbody fusion device includes superior and inferior plates that are configured to receive a sequentially inserted stack of expansion members or wafers in interlocking engagement. The superior and inferior plates have openings therethrough in communication with aligned holes through the wafers for receipt and containment of bone graft to promote fusion between opposing vertebral bodies. One of said superior and inferior endplates has a multi-contoured opening extending therethrough. |