Document Document Title
US08674450B1 Semiconductor structures and fabrication method
A method is provided for fabricating a semiconductor structure. The method includes providing a semiconductor substrate, and forming a shallow trench isolation structure in the semiconductor substrate. The method also includes forming a plurality of parallel gate structures on the semiconductor substrate surrounded by the shallow trench isolation structure. Further, the method includes forming a plurality of first trenches in the semiconductor substrate at least one side of the gate structures proximity to the shallow trench isolation structure, and forming a first silicon germanium layer with a first germanium concentration in each of the first trenches. Further the method also includes forming a plurality second trenches in semiconductor substrate at least one side of the gate structures farther from the shallow trench isolation structure, and forming a second silicon germanium layer with a second germanium concentration greater than the first germanium concentration in each of the second trenches.
US08674448B2 Trigate static random-access memory with independent source and drain engineering, and devices made therefrom
A static random-access memory circuit includes at least one access device including source and drain sections for a pass region, at least one pull-up device and at least one pull-down device including source-and-drain sections for a pull-down region. The static random-access memory circuit is configured with external resistivity (Rext) for the pull-down region to be lower than Rext for the pass region. Processes of achieving the static random-access memory circuit include source-and-drain epitaxy.
US08674443B2 Substrate provided with a semi-conducting area associated with two counter-electrodes and device comprising one such substrate
A support substrate comprises first and second counter-electrodes arranged in the same plane at the level of a surface of the support substrate. An electrically insulating area separates the first and second counter-electrodes. A semi-conducting area with first and second portions is separated from the support substrate by an electrically insulating material. The electrically insulating material is different from the material forming the support substrate. The first portion of the semi-conducting area is facing the first counter-electrode. The second portion of the semi-conducting area is facing the second counter-electrode.
US08674440B2 Power device integration on a common substrate
A semiconductor structure for facilitating an integration of power devices on a common substrate includes a first insulating layer formed on the substrate and an active region having a first conductivity type formed on at least a portion of the first insulating layer. A first terminal is formed on an upper surface of the structure and electrically connects with at least one other region having the first conductivity type formed in the active region. A buried well having a second conductivity type is formed in the active region and is coupled with a second terminal formed on the upper surface of the structure. The buried well and the active region form a clamping diode which positions a breakdown avalanche region between the buried well and the first terminal. A breakdown voltage of at least one of the power devices is a function of characteristics of the buried well.
US08674438B2 Semiconductor devices having stressor regions and related fabrication methods
Apparatus for semiconductor device structures and related fabrication methods are provided. One method for fabricating a semiconductor device structure involves forming a gate structure overlying a region of semiconductor material, wherein the width of the gate structure is aligned with a <100> crystal direction of the semiconductor material. The method continues by forming recesses about the gate structure and forming a stress-inducing semiconductor material in the recesses.
US08674437B2 Semiconductor device and method for manufacturing semiconductor device
A semiconductor device including a gate electrode formed over a first region of a semiconductor substrate of a first conduction type; a source region and a drain region of the first conduction type formed on both sides of the gate electrode; a channel dope layer of a second conduction type formed in at least a region on a side of the source region of a channel region, the channel dope layer having a concentration gradient of a concentration of a dopant impurity of the second conduction type, which decrease toward the drain region; a first well of the second conduction type having a concentration gradient of a concentration of a dopant impurity of the second conduction type, which decrease toward the drain region; and a second well of the second conduction type formed in the first region, connected to the first well and positioned below the first well.
US08674436B2 Lateral double diffusion metal-oxide semiconductor device and method for manufacturing the same
Disclosed is an LDMOS device, which is configured to reduce an electric field concentrated to a gate oxide film and lower an ON-resistance produced when the device conducts a forward action, and a method for manufacturing the same. More specifically, when an n-drift region is formed on a P-type substrate, a p-body is formed on the n-drift region through an epitaxial process, and then the p-body region is partially etched to form a plurality of p-epitaxial layers, so that when the device executes an action for blocking a reverse voltage, depletion layers are formed between the junction surfaces of the p-epitaxial layers and the n-drift region including the junction surfaces between the n-drift region and the p-body.
US08674435B2 Semiconductor integrated circuit device and method of manufacturing the same
A semiconductor integrated circuit device includes a first dopant region in a semiconductor substrate, an isolation region on the semiconductor substrate, the isolation region surrounding the first dopant region, a gate wire surrounding at least a portion of the isolation region, and a plurality of second dopant regions arranged along at least a portion of the gate wire, the plurality of second dopant regions being spaced apart from each other, and the portion of the gate wire being between the first dopant region and a respective second dopant region.
US08674431B2 Non-volatile semiconductor memory device and method of manufacturing the same
A method of manufacturing a non-volatile semiconductor memory device including previously forming a recess in a first peripheral region on a semiconductor substrate, forming a first gate insulator having a first thickness in the recess, forming a second gate insulator having a second thickness less than the first thickness in an array region and a second peripheral region on the semiconductor substrate, successively depositing first and second gate electrode films and first and second mask insulators on each of the first and second gate insulators, forming an isolation trench on a surface of the semiconductor substrate to correspond to each position between the array region and the first and second regions of the peripheral region, depositing a buried insulator on the entire surface, and polishing an upper surface of the buried insulator so that the upper surface can be planarized.
US08674429B2 Gate structure in non-volatile memory device
A gate structure of a non-volatile memory device and a method of forming the same including a tunnel oxide layer pattern, a charge trap layer pattern, a blocking dielectric layer pattern having the uppermost layer including a material having a first dielectric constant greater than that of a material included in the tunnel oxide layer pattern, and first and second conductive layer patterns. The gate structure includes a first spacer to cover at least the sidewall of the second conductive layer pattern. The gate structure includes a second spacer covering the sidewall of the first spacer and the sidewall of the first conductive layer pattern and including a material having a second dielectric constant equal to or greater than the first dielectric constant. In the non-volatile memory device including the gate structure, erase saturation caused by back tunneling is reduced.
US08674424B2 Memory device with charge storage layers at the sidewalls of the gate and method for fabricating the same
A memory device is described, including a gate over a substrate, a gate dielectric between the gate and the substrate, and two charge storage layers. The width of the gate is greater than that of the gate dielectric, so that two gaps are present at both sides of the gate dielectric and between the gate and the substrate. Each charge storage layer includes a body portion in one of the gaps, a first extension portion connected with the body portion and protruding out of the corresponding sidewall of the gate, and a second extension portion connected to the first extension portion and extending along the sidewall of the gate, wherein the edge of the first extension portion protrudes from the sidewall of the second extension portion.
US08674422B2 Asymmetric dense floating gate nonvolatile memory with decoupled capacitor
A nonvolatile memory (“NVM”) bitcell with one or more active regions capacitively coupled to the floating gate but that are separated from both the source and the drain. The inclusion of capacitors separated from the source and drain allows for improved control over the voltage of the floating gate. This in turn allows CHEI (or IHEI) to be performed with much higher efficiency than in existing bitcells, thereby the need for a charge pump to provide current to the bitcell, ultimately decreasing the total size of the bitcell. The bitcells may be constructed in pairs, further reducing the space requirements of the each bitcell, thereby mitigating the space requirements of the separate capacitor/s. The bitcell may also be operated by CHEI (or IHEI) and separately by BTBT depending upon the voltages applied at the source, drain, and capacitor/s.
US08674419B2 Method of forming a CMOS structure having gate insulation films of different thicknesses
The semiconductor integrated circuit device employs on the same silicon substrate a plurality of kinds of MOS transistors with different magnitudes of tunnel current flowing either between the source and gate or between the drain and gate thereof. These MOS transistors include tunnel-current increased MOS transistors at least one of which is for use in constituting a main circuit of the device. The plurality of kinds of MOS transistors also include tunnel-current reduced or depleted MOS transistors at least one of which is for use with a control circuit. This control circuit is inserted between the main circuit and at least one of the two power supply units.
US08674417B2 Solid-state imaging device and camera
A solid-state imaging device including: a substrate; a light-receiving part; a second-conductivity-type isolation layer; a detection transistor; and a reset transistor.
US08674416B2 Semiconductor device with reduced threshold variability having a threshold adjusting semiconductor alloy in the device active region
Generally, the subject matter disclosed herein is directed to semiconductor devices with reduced threshold variability having a threshold adjusting semiconductor material in the device active region. One illustrative semiconductor device disclosed herein includes an active region in a semiconductor layer of a semiconductor device substrate, the active region having a region length and a region width that are laterally delineated by an isolation structure. The semiconductor device further includes a threshold adjusting semiconductor alloy material layer that is positioned on the active region substantially without overlapping the isolation structure, the threshold adjusting semiconductor alloy material layer having a layer length that is less than the region length. Additionally, the disclosed semiconductor device includes a gate electrode structure that is positioned above the threshold adjusting semiconductor alloy material layer, the gate electrode structure including a high-k dielectric material and a metal-containing electrode material formed above the high-k dielectric material.
US08674413B1 Methods of forming fins and isolation regions on a FinFET semiconductor device
One illustrative device disclosed herein includes a substantially un-doped layer of a semiconductor material positioned above a semiconducting substrate, a device isolation structure, at least a portion of which is positioned in a trench that extends through the substantially un-doped semiconductor material and into the substrate, a plurality of outer fins and at least one inner fin defined in the substantially un-doped layer of semiconductor material, wherein the at least one inner fin is positioned laterally between the plurality of outer fins and wherein a width of a bottom of each of the plurality of outer fins is greater than a width of a bottom of the inner fin, and a gate electrode positioned around at least a portion of the plurality of outer fins and the inner fin.
US08674411B2 Semiconductor device employing circuit blocks having the same characteristics
A semiconductor device is disclosed, which comprises first and second input ports, first and second output nodes, and first and second transistors. The first transistor includes first and second diffusion regions defining a first channel region and a first gate electrode and connected to the first input port, the first diffusion region being connected to the first output node, the second diffusion region being disposed between the first diffusion region and the first input port and supplied with a first operating potential. The second transistor includes third and fourth diffusion regions defining a second channel region and a second gate electrode and connected to the second input port, the third diffusion region being supplied with the first operating potential, the fourth diffusion region being disposed between the third diffusion region and the second input port and connected to the second output node.
US08674410B2 Method of manufacturing metal silicide and semiconductor structure using the same
A method of manufacturing a metal silicide is disclosed below. A substrate having a first region and a second region is proviced. A silicon layer is formed on the substrate. A planarization process is performed to make the silicon layer having a planar surface. A part of the silicon layer is removed to form a plurality of first gates on the first region and to form a plurality of second gates on the second region. The height of the first gates is greater than the height of the second gates, and top surfaces of the first gates and the second gates have the same height level. A dielectric layer covering the first gates and the second gates is formed and exposes the top surfaces of the first gates and the second gates. A metal silicide is formed on the top surfaces of the first gates and the second gates.
US08674409B2 Heterojunction field effect transistor, method for producing heterojunction field effect transistor, and electronic device
A heterojunction filed effect transistor with a low access resistance, a low on resistance, and the like, a method for producing a heterojunction filed effect transistor and an electron device are provided. In the heterojunction field effect transistor, an electron transit layer 11 formed of a III-nitride semiconductor is formed on a substrate 10, an electron supply layer 12 formed of a III-nitride semiconductor forms a heterojunction with an upper surface of the electron transit layer 11, a gate electrode 14, a source electrode 15A, and a drain electrode 15B are arranged on the electron supply layer 12, n-type conductive layer regions 13A and 13B each extended from an upper part of the electron transit layer 11 to an upper surface of the electron supply layer 12 are provided in at least a part below the source electrode 15A and a part below the drain electrode 15B, and an n-type impurity concentration at a heterojunction interface of an electron transit layer 11 part of each of the n-type conductive layer regions 13A and 13B with the electron supply layer 12 is 1×1020 cm−3 or more.
US08674408B2 Reducing source/drain resistance of III-V based transistors
An integrated circuit structure includes a substrate; a channel layer over the substrate, wherein the channel layer is formed of a first III-V compound semiconductor material; a highly doped semiconductor layer over the channel layer; a gate dielectric penetrating through and contacting a sidewall of the highly doped semiconductor layer; and a gate electrode on a bottom portion of the gate dielectric. The gate dielectric includes a sidewall portion on a sidewall of the gate electrode.
US08674407B2 Semiconductor device using a group III nitride-based semiconductor
The present invention provides a semiconductor device having such a structure formed by sequentially laminating a lower barrier layer composed of lattice-relaxed AlxGa1-xN (0≦x≦1), a channel layer composed of InyGa1-yN (0≦y≦1) with compressive strain and a contact layer composed of AlzGa1-zN (0≦z≦1), wherein a two-dimensional electron gas is produced in the vicinity of an interface of said InyGa1-yN channel layer with said AlzGa1-zN contact layer; a gate electrode is formed so as to be embedded in the recessed portion with intervention of an insulating film, which recessed portion is formed by removing a part of said AlzGa1-zN contact layer by etching it away until said InyGa1-yN channel layer is exposed; and, ohmic electrodes are formed on the AlzGa1-zN contact layer. Thus, the semiconductor device has superior uniformity and reproducibility of the threshold voltage while maintaining a low gate leakage current, and is also applicable to the enhancement mode type.
US08674406B2 Extended wavelength digital alloy NBN detector
A strain-balanced photodetector is provided for detecting infrared light at an extended cutoff wavelength in the range of 4.5 μm or more. An InAsSb absorber layer has an Sb content is grown in a lattice-mismatched condition to a GaSb substrate, and a plurality of GaAs strain-compensating layers are interspersed within the absorber layer to balance the strain of the absorber layer due to the lattice mismatch. The strain-compensation layers allow the absorber to achieve a thickness exhibiting sufficient absorption efficiency while extending the cutoff wavelength beyond that possible in a lattice-matched state. Additionally, the strain-compensation layers are sufficiently thin to be substantially quantum-mechanically transparent such that they do not substantially affect the transmission efficiency of the absorber. The photodetector is preferably formed as a majority carrier filter photodetector exhibiting minimal dark current, and may be provided individually or in a focal plane array.
US08674402B2 Power semiconductor device and methods for fabricating the same
A power semiconductor device includes: a drain region of a first conductive type; a drift region of a first conductive type formed on the drain region; a first body region of a second conductive type formed below an upper surface of the drift region; a second body region of a second conductive type formed below the upper surface of the drift region and in the first body region; a third body region of a second conductive type formed by protruding downwards from a lower end of the first body region; a source region of a first conductive type formed below the upper surface of the drift region and in the first body region; and a gate insulating layer formed on channel regions of the first body region and on the drift region between the first body regions.
US08674401B2 Deep diffused thin photodiodes
This invention comprises photodiodes, optionally organized in the form of an array, including p+ deep diffused regions or p+ and n+ deep diffused regions. More specifically, the invention permits one to fabricate thin 4 inch and 6 inch wafer using the physical support provided by a n+ deep diffused layer and/or p+ deep diffused layer. Consequently, the present invention delivers high device performances, such as low crosstalk, low radiation damage, high speed, low leakage dark current, and high speed, using a thin active layer.
US08674394B2 Light emitting device package and method of manufacturing the same
A light emitting device package includes a base, a light emitting element, a mask, metal wires, an encapsulating layer and a cover layer. The base has a first surface bearing electrical structure thereon and an opposite second surface. The mask is arranged on the first surface to define a space receiving the light emitting element. Two openings are defined in the mask. The light emitting element has two pads exposed to an outside through the two openings respectively. The metal wires electrically connect the pads and the electrical structures. The encapsulating layer is filled in the space and two through holes in the base and encapsulates the light emitting element. The encapsulating layer is separated from the metal wires. The cover layer covers and protects the mask and the metal wires. A method of manufacturing the package is also provided.
US08674392B2 Light-emitting device
Disclosed is a light-emitting device that exhibits good color rendering and highly efficiently emits white light in an incandescent bulb color range. The semiconductor light-emitting device (1) of the present invention includes: a semiconductor light-emitting element (2) that emits blue light; a green phosphor (14) that absorbs the blue light and emits green light; and an orange phosphor (13) that absorbs the blue light and emits orange light. The orange phosphor (13) produces an emission spectrum having a peak at a wavelength of equal to or greater than 590 nm but equal to or less than 630 nm and having a full width at half maximum of 130 nm or greater at the peak, the full width at half maximum of the emission spectrum of the orange phosphor (13) being broader than a full width at half maximum of an emission spectrum of the green phosphor (14). The orange phosphor (13) exhibits an absorptance having a peak wavelength of 420 nm or greater. ABS(530) and ABS(MAX) satisfy a relation, ABS(530)/ABS(MAX)<0.60, where ABS(MAX) is an absorptance of the orange phosphor (13) at the peak wavelength thereof, and ABS(530) is an absorptance of the orange phosphor (13) at a wavelength of 530 nm.
US08674390B2 Semiconductor nanoparticle-containing materials and light emitting devices incorporating the same
In various embodiments, the present invention provides a light emitting device cap configured for location on a light emitting device comprising or consisting essentially of a primary light source. The cap defines a well region within which is received a population of semiconductor nanoparticles such that the semiconductor nanoparticles are in optical communication with the primary light source of the light emitting device when the cap is located on the light emitting device. There is further provided a light emitting device comprising or consisting essentially of a primary light source and such a cap, as well as methods for fabricating such a cap and device.
US08674388B2 Phosphor, method of manufacturing the same, and light-emitting device
The present invention is a phosphor expressed by the general formula (A1−xRxM2X)m(M2X4)n (wherein the element A is one or more types of element selected from Li, Na, Be, Mg, Ca, Sr, Ba, Sc, Y, La, Gd, and Lu, the element R is one or more types of activating agent selected from Mn, Ce, Pr, Nd, Sm, Eu, Tb, Dy, Ho, Er, Tm, and Yb, the element M is one or more types of element selected from Si, Ge, Sn, Ti, Hf, Zr, Be, B, Al, Ga, In, Tl, and Zn, the element X is one or more types of element selected from oxygen and nitrogen, n and m are integers of 1 or more, and x is a real number defined by 0
US08674387B2 Light emitting device
A light emitting device is provided with a base member, an interconnect pattern disposed on an upper surface of the base member, a light reflecting layer comprising a first layer disposed on a part of the interconnect pattern and formed from a metal material, and a second layer made of a dielectric multilayer reflecting film made with stacked layers of dielectric films having different refractive indices and covering an upper surface and side surfaces of the first layer, a light emitting element chip fixed so as to face at least a part of the light reflecting layer, and a light transmissive sealing member sealing the light reflecting layer and the light emitting element chip.
US08674386B2 Diode having high brightness and method thereof
A light emitting diode includes a transparent substrate and a GaN buffer layer on the transparent substrate. An n-GaN layer is formed on the buffer layer. An active layer is formed on the n-GaN layer. A p-GaN layer is formed on the active layer. A p-electrode is formed on the p-GaN layer and an n-electrode is formed on the n-GaN layer. A reflective layer is formed on a second side of the transparent substrate. Also, a cladding layer of AlGaN is between the p-GaN layer and the active layer.
US08674384B2 Light emitting element
According to one embodiment, a light emitting element includes a light emitting layer, a cladding layer, a current spreading layer, a second layer, and an electrode. The light emitting layer is capable of emitting emission light. The current spreading layer includes a surface processed layer and a first layer. The surface processed layer has a surface including convex portions and bottom portions provided adjacent to the convex portions. The first layer is provided between the surface processed layer and the cladding layer. The second layer is provided between the surface processed layer and the cladding layer and includes a region having an impurity concentration higher than an impurity concentration of the current spreading layer. The electrode is provided in a region of the surface of the surface processed layer where the convex portions and the bottom portions are not provided.
US08674382B2 Semiconductor light emitting device comprising heterojunction
A semiconductor light emitting device (10) comprises a semiconductor structure (12) comprising a first body (14) of a first semiconductor material (in this case Ge) comprising a first region of a first doping kind (in this case n) and a second body (18) of a second semiconductor material (in this case Si) comprising a first region of a second doping kind (in this case p). The structure comprises a junction region (15) comprising a first heterojunction (16) formed between the first body (14) and the second body (18) and a pn junction (17) formed between regions of the structure of the first and second doping kinds respectively. A biasing arrangement (20) is connected to the structure for, in use, reverse biasing the pn junction, thereby to cause emission of light.
US08674372B2 HEMT with integrated low forward bias diode
A high electron mobility transistor includes a source, gate and drain, a first III-V semiconductor region having a two-dimensional electron gas (2DEG) which provides a first conductive channel controllable by the gate between the source and drain, and a second III-V semiconductor region below the first III-V semiconductor region and having a second conductive channel connected to the source or drain and not controllable by the gate. The first and second III-V semiconductor regions are spaced apart from one another by a region of the high electron mobility transistor having a different band gap than the first and second III-V semiconductor regions.
US08674370B2 Light emitting panel device wherein a plurality of panels respectively having light emitting sections are connected, and image display device and illuminating device provided with the light emitting panel device
Panel (11) of the present invention includes substrate (12) having flat surface (12a′) having rectangular display section (13), and adjacent surface (12b′) curved from an edge part of surface (12a′) in the vicinity of a long side of surface (12a′). On surface (12b′), terminals, extending from display section (13) (in the vicinity of the long side), are arranged. Edge parts of surfaces (12a′) of substrates (12) of adjacent panels (11) are combined so that longitudinal directions of light-emitting sections (13) are parallel to each other. Surface (12b′) projects on a back surface side of substrate (12). It is thus possible to provide a light-emitting panel device realizing a large light-emitting surface by combining a desired number of panels, an image display device including the light-emitting panel device, an illumination device including the light-emitting panel device, a panel in the light-emitting panel device, and a method of producing the panel.
US08674365B2 Array substrate and manufacturing method thereof
A manufacturing method of an array substrate includes the following steps. A first conductive layer, a gate insulating layer, a semiconductor layer, an etching stop layer, and a first patterned photoresist are successively formed on a substrate. The etching stop layer and the semiconductor layer uncovered by the first patterned photoresist are then removed by a first etching process. A patterned gate insulating layer and a patterned etching stop layer are then formed through a second etching process. The first conductive layer uncovered by the patterned gate insulating layer is then removed to form a gate electrode. The semiconductor layer uncovered by the patterned etching stop layer is then removed to form a patterned semiconductor layer and partially expose the patterned gate insulating layer.
US08674356B2 Electrically measurable on-chip IC serial identifier and methods for producing the same
An apparatus comprising an integrated circuit, an interconnect layer within said integrated circuit, and one or more connections. The integrated circuit may be configured to provide an electrically measurable interconnect pattern by enabling one or more of a plurality of components. The one or more connections may each configured to enable a respective one of the components. The connections may be programmable while the apparatus is part of a wafer. The interconnect pattern may be configured to identify the apparatus after the apparatus has been manufactured.
US08674353B2 Organic electroluminescence element, display device using organic electroluminescence element, and method of manufacturing organic electroluminescence element
One embodiment of the present invention is an organic electroluminescence element including: a substrate; a first electrode that is formed on the substrate; a luminescent medium layer that includes at least an organic luminescent layer and one or more functional layers other than the organic luminescent layer formed on the first electrode; and a second electrode that faces the first electrode with the luminescent medium layer interposed therebetween, wherein at least one functional layer formed between the first electrode and the organic luminescent layer includes first and second metal compounds and the functional layer is a functional layer in which a gradient is obtained at least partially in a film thickness direction for a ratio of the first metal compound to the second metal compound.
US08674349B2 Resin film forming sheet for chip, and method for manufacturing semiconductor chip
A sheet for forming a resin film for a chip, with which a semiconductor device is provided with a gettering function, is obtained without performing special treatment to a semiconductor wafer and the chip. The sheet has a release sheet, and a resin film-forming layer, which is formed on the releasing face of the release sheet, and the resin film-forming layer contains a binder polymer component, a curing component, and a gettering agent.
US08674347B2 Organic semiconductor material and organic thin-film transistor
An organic thin-film transistor comprising a gate electrode, a gate insulator layer, an organic semiconductor layer, a source electrode and a drain electrode wherein the organic semiconductor layer consists of the organic semiconductor material having the structure represented by the general formula (1) shown below, and the organic semiconductor layer has crystallinity: wherein L represents a bivalent linker group having the structure consisting of one group or any combination of two or more groups selected from unsubstituted or fluorinated benzene residue, unsubstituted or fluorinated thiophene residue, unsubstituted or fluorinated thienothophene residue; R1 represents carbonyl group, cyano group or C1-C6 fluorinated alkyl group; R2 represents halogen atom, cyano group, carbonyl group or acetyl group.
US08674344B2 Display device and organic light emitting diode display
A display device includes: a display substrate; a display formed on the display substrate; an encapsulation substrate affixed to the display substrate by an adhering layer surrounding the display, the display substrate including a composite member including a resin matrix and a plurality of carbon fibers and an insulation member attached to an edge of the composite member and forming a through hole; a metal layer positioned on a side of the encapsulation substrate facing the substrate; and a conductive connector filling the through hole and contacting the metal layer. The composite member is stacked with at least two layers with different sizes, and the insulation member contacts sides of the at least two layers and has the same thickness as the composite member.
US08674343B2 Organic light-emitting diodes having white light emission
There is provided an organic light-emitting diode luminaire. The luminaire includes a first electrode, a second electrode, and an electroluminescent layer therebetween. The electroluminescent layer includes: a first electroluminescent material having an emission color that is blue-green; and a second electroluminescent material having an emission color that is red/red-orange. The additive mixing of the emitted colors results in an overall emission of white light.
US08674341B2 High-mobility multiple-gate transistor with improved on-to-off current ratio
A multi-gate transistor includes a semiconductor fin over a substrate. The semiconductor fin includes a central fin formed of a first semiconductor material; and a semiconductor layer having a first portion and a second portion on opposite sidewalls of the central fin. The semiconductor layer includes a second semiconductor material different from the first semiconductor material. The multi-gate transistor further includes a gate electrode wrapping around sidewalls of the semiconductor fin; and a source region and a drain region on opposite ends of the semiconductor fin. Each of the central fin and the semiconductor layer extends from the source region to the drain region.
US08674333B2 Variable-resistance material memories and methods
Variable-resistance memory material cells are contacted by vertical bottom spacer electrodes. Variable-resistance material memory spacer cells are contacted along the edge by electrodes. Processes include the formation of the bottom spacer electrodes as well as the variable-resistance material memory spacer cells. Devices include the variable-resistance memory cells.
US08674332B2 RRAM device with an embedded selector structure and methods of making same
One device disclosed herein includes first and second sidewall spacers positioned above a semiconducting substrate, wherein the first and second sidewall spacers are comprised of at least a conductive material, a conductive word line electrode positioned between the first and second sidewall spacers and first and second regions of variable resistance material positioned between the conductive word line electrode and the conductive material of the first and second sidewall spacers, respectively. This example also includes a base region of a bipolar transistor in the substrate below the word line electrode, an emitter region formed below the base region and first and second collector regions formed in the substrate within the base region, wherein the first collector region is positioned at least partially under the first region of variable resistance material and the second collector region is positioned at least partially under the second region of variable resistance material.
US08674328B2 Remote nanoscale photochemistry using guided emission in nanowires
A method of fabricating a nanodevice includes providing a nanowire having a first portion and a second portion. The nanowire has a polymer coating. A nanostructure is provided that is proximate to the second portion of the nanowire. Solely the first portion of the nanowire is irradiated with near-infrared radiation, thereby exciting the first portion to generate ultraviolet radiation. The generated ultraviolet radiation is guided from the first portion along the nanowire toward the second portion, so that a region of the polymer coating on the second portion is polymerized and bonds the nanostructure to the nanowire.
US08674326B2 Driving type patient platform, control device for driving type patient platform, control program for driving type patient platform, and particle beam therapy system utilizing these items
A patient platform for making the position and posture of a diseased site coincide with those established by a treatment plan. Translation units translate a top board in the X, Y and Z directions respectively, in a fixed coordinate system. Rotation units rotate the top board in the θ, φ, and ξ directions respectively. A controller controls the translation units and rotation units, based on desired rotation center point and desired rotation angle. The controller has a rotation drive signal generation unit that generates a signal for moving the top board in a rotating manner from the reference state “a” of the translation units and the rotation units to a desired rotation angle; and a translation drive signal generation unit that generates a signal for translating the translation units so the amount of translation movement, of the desired rotation center point, caused by the rotation movement is a predetermined value.
US08674319B2 Beam monitor system and particle beam irradiation system
Disclosed is a beam monitor system in which signals outputted from a plurality of wires are divided in a multi-wire type monitor for measuring a beam profile of a charged particle beam, an identical number of the wires are grouped, the signals of the respective groups are taken out one piece by one piece to be connected with each other, and the number of the pieces, corresponding to a number of the wires belonging to the one group, are put together to be connected to a signal processor storing connection information.
US08674311B1 Polycrystalline lanthanum halide scintillator, devices and methods
Evaporation methods and structures for depositing a scintillator film on a surface of a substrate. A radiation detection device including a doped lanthanum halide polycrystalline scintillator formed on a substrate.
US08674310B2 Light emitting ceramic, light emitting element, scintillator, and method for producing light emitting ceramic
Provided is a light emitting ceramic such as a wavelength conversion ceramic or a radiation-to-light conversion ceramic, which emits light when radiation or light enters the ceramic, and which has a short light emission decay time. The light emitting ceramic is obtained by applying a heat treatment in a reducing atmosphere to a ceramic containing, as its main constituent, a pyrochlore compound represented by ABOw where A includes at least one of La, Y, Gd, Yb, and Lu, and 0 to 5 mol % of Bi; B is at least one of Sn, Zr, and Hf; and w is a positive number for maintaining electroneutrality.
US08674309B2 Scintillator crystal body, method for manufacturing the same, and radiation detector
In a scintillator used for radiation detection, such as an X-ray CT scanner, a scintillation crystal body having a unidirectional phase separation structure is provided which has a light guide function for crosstalk prevention without using partitions. The phase separation structure includes a first crystal phase and a second crystal phase having a refractive index larger than that of the first crystal phase and which have a first principal surface and a second principal surface, these principal surfaces being not located on the same plane, the first principal surface and the second principal surface have portions to which the second crystal phase is exposed, and a portion of the second crystal phase exposed to the first principal surface and a portion of the second crystal phase exposed to the second principal surface are connected to each other.
US08674307B2 System and method for detecting infrared radiation
A device for detecting infrared radiation comprising an array of bolometers for detecting radiation; and in order to read each bolometer, a signal shaping circuitry comprising: a circuitry capable of biasing the bolometer at a predetermined voltage in order to make current flow therethrough; a circuitry capable of generating a common-mode current; and a circuitry capable of integrating the difference between the current that flows through the bolometer and the common-mode current. According to the invention, the device comprises a circuitry capable of injecting current into each bolometer in order to shift its resistance by a predetermined quantity that depends on its offset, current injection being performed prior to readout biasing of the bolometer and the shift being performed according to the direction in which the bolometer's resistance varies as a function of temperature. In addition, correction circuitry is capable of shifting the resistances of bolometers towards a common value.
US08674305B2 Opto-electronic module and devices comprising the same
An opto-electronic module includes a detecting channel comprising a detecting member for detecting light and an emission channel comprising an emission member for emitting light generally detectable by said detecting member. Therein, a radiation distribution characteristic for an emission of light from said emission channel is non rotationally symmetric; and/or a sensitivity distribution characteristic for a detection in said detecting channel of light incident on said detection channel is non rotationally symmetric; and/or a central or main emission direction for an emission of light from said emission channel and a central or main detection direction for a detection of light incident on said detection channel are aligned not parallel to each other; and/or at least a first one of the channels comprises one or more passive optical components.
US08674294B2 System of electrospray ion generator
This invention relates to an analytical instrument field, specifically an instrument for pharmaceutical micromolecular and biological macromolecular ion generation. By this invention, through a hollow capillary emission needle and an emission needle bracket, the emission needle bracket forms a forward moving laminar flow gas surrounding the emission needles, eliminating the capillary counter-flow effect outside the capillary for liquid flowing out of the hollow capillary emission needle and pushing liquid forward; and vacuum lead-in capillary whose entrance is a specially designed arc mechanism, makes zero air flow speed in any direction, and the entrance happens to be the exit of the hollow capillary emission needle so as to ensure steady Taylor cone on the tip edge and ultimately obtains steady ion flow within a large flow range. This invention has advantages of steady ion emission and high ion transmission efficiency, and can be widely applied in the ion source preparation.
US08674289B2 Isotopic abundance in atom trap trace analysis
A method and system for detecting ratios and amounts of isotopes of noble gases. The method and system is constructed to be able to measure noble gas isotopes in water and ice, which helps reveal the geological age of the samples and understand their movements. The method and system uses a combination of a cooled discharge source, a beam collimator, a beam slower and magneto-optic trap with a laser to apply resonance frequency energy to the noble gas to be quenched and detected.
US08674285B2 Vehicle rearview mirror system
A vehicle interior rearview mirror system includes an interior rearview mirror assembly having a reflective element and ambient and glare light sensors. A control circuit is operable to establish a reflectance level of the reflective element. At least one of (a) the mirror system includes a charge accumulation device selectively connected with the ambient or glare light sensor and the control circuit establishes the ambient and glare light levels as a function of time for an output of the charge accumulation device to reach a reference level when connected to the respective light sensor, (b) a common element is used to measure outputs of the light sensors sequentially to correspond errors due to component variations, and (c) the mirror system includes temperature compensation of the glare and/or ambient light sensor and the temperature compensation is responsive to a reference light sensor that is substantially not exposed to light.
US08674280B1 Concentration solar power optimization system and method of using same
A system and method for optimizing at least one mirror of at least one CSP system is provided. The system has a screen for displaying light patterns for reflection by the mirror, a camera for receiving a reflection of the light patterns from the mirror, and a solar characterization tool. The solar characterization tool has a characterizing unit for determining at least one mirror parameter of the mirror based on an initial position of the camera and the screen, and a refinement unit for refining the determined parameter(s) based on an adjusted position of the camera and screen whereby the mirror is characterized. The system may also be provided with a solar alignment tool for comparing at least one mirror parameter of the mirror to a design geometry whereby an alignment error is defined, and at least one alignment unit for adjusting the mirror to reduce the alignment error.
US08674279B1 Independently powered solar tracker controlling device with program to select alternative source of power supply to assure functionality
A dual axis motorized solar tracking device that can be rotated over 360° and wherein the solar array panel thereof can be tilted from 90° to 10° and wherein the motorized portions of said device is controlled by an internally contained computerized controlling system that is programmed to follow the path of the sun at the installed location thereof and also to adjust the system to allow for any problems in weather. The internally contained computerized controlling device is electrically actuated from a plethora of sources including a separate panel on the solar array dedicated to recharging an energy storage cell system that will power up the internally contained and computerized controlling system. Alternatively, other power sources external to the device may also be employed giving this system a unique ability to keep on running while charging the energy storage cell system under any circumstances. A lithium-ion battery can be used as the rechargeable battery system.
US08674275B2 Method of fabricating a honeycomb structure using microwaves
A microwave applicator assembly includes a microwave applicator that excites TE modes and provides a generally circular heating pattern in a lossy dielectric material. The microwave applicator has a processing chamber bounded by a circumferential wall in which a plurality of indents are formed. The microwave applicator assembly may further include a feed waveguide coupled to the microwave applicator for inputting microwaves into the processing chamber. The microwave applicator assembly may further include one or more choking sections in communication with the processing chamber to enhance heating efficiency and reduce microwave leakage.
US08674271B2 Method of using a topical application device
A breathable electrical heater element for a topical application device such as a wound dressing or a therapeutic heating pad is disclosed. The heater element is formed by photochemically etching a track pattern onto a porous metallised fabric (e.g. nickel coated woven polyester). The heater element has a skin or wound contact layer laminated to the front face of the heater element. An adhesive layer is laminated to the back face of the heater element. The adhesive layer forms an overhang to provide an adhesive border around the wound contact layer to adhere the device to the skin of a patient. Therapeutically active drugs (optionally microencapsulated) may be incorporated into the skin or wound contact layer. Operation of the heater element causes the skin or wound contact layer to release the active drugs to the skin or wound of the patient. Appropriate control of the temperature of the heater element allows control of the release of the active drugs.
US08674270B2 Cooking appliance with programmable recipe system
A cooking appliance includes an oven cavity and a control system having a control display adapted to display an interactive sequence of display screens through which a user enters a cooking recipe. The sequence of display screens includes a cooking mode selection screen, a cooking temperature selection screen, a cooking monitoring selection screen from which a user selects from a probe monitoring process or a timer monitoring process, and a review screen for prompting the user to review the cooking mode, cooking temperature, and method of monitoring selections. The system allows a user to add additional stages to create a multi-stage recipe.
US08674269B2 Safe product transfer apparatus
A safe product transfer apparatus that heats refrigerated food products and then hold those heated food products in a hold drawer until they can be transferred to a heater merchandizer, preferably a roller grill as needed. The apparatus features a control assembly. A pre-heat indicator indicates when the preheat temperature has been reached so that the food products can be loaded into an operable drawer. The apparatus can heat a refrigerated product from 34° F. to greater than or equal to 140° F. in 35 minutes or less. The apparatus has a safe product transfer apparatus that has a heating cavity ranging from 250° F. to 425° F. The apparatus provides a safe product transfer apparatus that can hold the products stored therein at a safe holding temperature (ranging from greater or equal to 140° F. to not more than 205° F.), that is, not hot enough to continue heating or degrading the food product.
US08674268B2 Heated water bucket
The heated water bucket includes a rubber bodied bucket with an integrated heating unit fitted to the bottom of the bucket. The heating unit covers the entire bottom of the bucket acting as a false “bottom” so that the heating unit does not appear as a foreign object within the bucket. The heating unit is held to the bottom of the bucket by a peripheral flange that extends radially around the inside of the bucket sidewall. The rubber construction of the bucket itself makes the invention more durable, but also improves the bucket's thermal insulation properties, making it more efficient than conventional heated plastic buckets.
US08674263B2 Wire guiding liner, in particular a welding wire liner, with biasing means between articulated guiding bodies
The present disclosure relates to a wire guiding liner, in particular a welding wire liner, having a plurality of guiding bodies which are pivotable with respect to each other around a defined pivot axis. At least one biasing device is provided which acts between adjacent guiding bodies so as to push them apart while still allowing the liner to bend under pressure.
US08674261B2 Method for manufacturing a solar cell module by laser bonding
The present invention relates to a method and apparatus for manufacturing a solar cell module using a laser. In the present invention, a tabbing process for bonding a solar cell and metal electrodes is performed by a local irradiation with a laser, so that the heating area can be localized only to a required zone (bonding area) for the tabbing process, thereby minimizing a direct heating zone which occurs in the process. Therefore, it is possible to reduce the damage such as cracks and breakage due to thermal expansion/contraction of a solar cell which is conventionally configured to have a multi-layered structure made of different materials, to improve the bonding strength and the bonding uniformity, and to reduce the processing time, thereby improving the production efficiency.
US08674260B2 Method for production of safety/rupture discs
A method for production of safety/rupture discs comprises the steps providing a foil element, selecting a wavelength for a laser beam of a pulse laser within a range of between 800 nanometers and 1800 nanometers, selecting a pulse repetition rate for the laser beam within a range of between 15 KHz and 800 KHz, selecting a pulse duration for the laser beam less than 10 nanosecond and ablating at least one non-through cut in the foil element by directly applying said laser beam to the foil element to remove material from the foil element thereby obtaining a safety/rupture disc.
US08674259B2 Manufacturing system for producing reverse-tapered orifice
A manufacturing system for producing a reverse-tapered orifice is disclosed. The manufacturing system may have a mount configured to hold a workpiece, and a laser source configured to generate a laser beam. The manufacturing system may also have a delivery media operatively connected to the laser source. The delivery media may be configured to deliver the laser beam into a hollow portion of the workpiece to create the orifice through a wall of the workpiece having a laser beam entrance opening larger than a laser beam exit opening.
US08674258B2 Method and apparatus for scale manufacture without substantial removal of material
A method of making metrological scale for scale reading apparatus includes directing a laser beam onto a scale substrate (12). The laser parameters are such that the local area of the scale substrate (12) on which the laser beam is incident is caused to be displaced, thus creating scale markings (16, 20, 22).
US08674254B2 Flexible seal for high voltage switch
An electrical switch includes a tubular housing that includes an interface positioned intermediate the conductor receiving end and the operating end. An operating rod extends through the housing. A fixed contact is electrically coupled to the operating end. A moveable contact is electrically coupled to the interface and the operating rod, wherein the moveable contact is moveable between a first position contacting the fixed contact and a second position separated from the fixed contact. A diaphragm is positioned in the tubular housing between the interface and the operating end and includes a first tubular portion and a second tubular portion. Movement of the operating rod from the first position to the second position causes the second tubular portion to move relative to the first tubular portion, thus deforming the shoulder portion.
US08674253B2 Gas insulation apparatus
According to an embodiment, a gas insulation apparatus (e.g., a gas circuit breaker) includes a high-voltage unit, a zeolite and an insulation gas in a closed vessel. The insulation gas is CO2 gas or a gas including CO2 gas as the main component. The zeolite is contained in a zeolite case and is placed under an insulation gas atmosphere. CO2 is adsorbed on the zeolite before use of the gas insulation apparatus.
US08674244B2 Time difference adders, time difference accumulators, sigma-delta time-to-digital converters, digital phase locked loops and temperature sensors
A time difference adder included in a system-on-chip (SOC) includes a first register unit and a second register unit. The first register unit is configured to receive first and second input signals having a first time difference, and generate a first output signal in response to a first signal. The second register unit is configured to receive third and fourth input signals having a second time difference, and generate a second output signal having a third time difference with respect to the first output signal in response to the first signal. The third time difference corresponds to a sum of the first time difference and the second time difference.
US08674243B2 Automated side loading collection and scale system
The disclosure describes a novel approach of utilizing a collection bin for a side loading waste collection vehicle. The collection bin includes a weighing system with a processor for measuring the weight of material collected from each waste container and associating this weight with appropriate data, such as the owner of the waste container.
US08674240B2 Transition frame with integrated compression unit
A frame for receiving one or more modules for cable entries or pipe penetrations. A compression unit is an integrated part of the frame in at least one embodiment, which compression unit is to compress the modules inside the frame. The compression unit includes three compression wedges. An upper and a lower compression wedge have the same orientation, while a middle compression wedge has an opposite orientation. The middle compression wedge is oriented with a broad side facing an opening of the frame receiving the modules. At least one compression screw goes through openings of the upper and lower compression wedges and through a slot in the middle compression wedge.
US08674238B2 Guideway mechanism
An exemplary guideway mechanism includes two branches, a group of connecting blocks, and a supporting bracket. The group of connecting blocks includes four connecting blocks arranged at four corners of an imaginary square and connecting the supporting bracket. Each branch includes two parallel rails. Adjacent ends of the rails of each branch respectively connect two adjacent connecting blocks.
US08674236B2 Wiring substrate and method of manufacturing the same
A wiring substrate is configured such that each of laminate portions provided above and below a substrate core includes insulating layers and conductor layers stacked alternately. Of the conductor layers of the laminate portions, signal line layers are treated with a silane coupling treatment, which is a surface modification treatment, so that each signal line comprises a flat surface. A roughening treatment is performed on the remaining conductor layers of the laminate portions such that the surfaces of these layers are roughened. This structure provides an advantage when high-frequency signals are transmitted through the signal line layers. That is, when each signal line comprises a flat surface, an increase in conductor loss due to the skin effect can be prevented. In addition, by means of chemical bonding attained through the silane coupling treatment, the reliability of adhesion between the signal line layers and the insulating layer is sufficiently attained.
US08674233B2 Photosensitive conductive film, method for forming conductive film, method for forming conductive pattern, and conductive film substrate
A photosensitive conductive film 10 according to the invention includes a support film 1, a conductive layer 2 containing conductive fiber formed on the support film 1, and a photosensitive resin layer 3 formed on the conductive layer 2.
US08674228B2 Longitudinal shield tape wrap applicator with edge folder to enclose drain wire
A shielded electrical wire and device that includes a first folding die configured to fold a first edge of a shield tape a first direction from a central portion of the shield tape and to fold a second edge of the shield tape a second direction opposite to the first direction from the central portion of the shield tape, a second folding die configured to wrap the shield tape around at least two insulated conductors to apply a fold to the first edge of the shield tape so as to fold the first edge back over onto the central portion of the shield tape to form a receiving area, a third folding die configured to tighten the shield tape around the plurality of conductors while positioning the receiving area to receive a drain wire, a wire guide configured to install a drain wire in the receiving area, and a closing die configured to close the shield tape around the plurality of conductors and the drain wire to form an enclosure around the plurality of conductors with the second edge overlapping the receiving area at an outside surface of the enclosure.
US08674226B2 High speed data cable including a boost device for generating a differential signal
A high speed video cable carries signals according to the High-Definition Multimedia Interface (HDMI), and includes a raw cable and a boost device. Each of four high speed video signals is carried on the inner conductors of a pair of coaxial lines in the raw cable. The boost device receives only one of the polarities of one of the high speed video signals, and generates a differential signal therefrom. Lower speed signals are carried on the galvanically or capacitively coupled shields of a pair of coaxial lines.
US08674225B2 Economical boosted high speed data cable
A high speed video cable carries signals according to the High-Definition Multimedia Interface (HDMI), and includes a raw cable and a boost device. Each of four high speed video signals is carried on the inner conductors of a pair of coaxial lines in the raw cable. Lower speed signals are carried on the galvanically or capacitively coupled shields of a pair of coaxial lines.
US08674223B2 High speed data cable with impedance correction
A high speed video cable carries signals according to the High-Definition Multimedia Interface (HDMI) or DisplayPort standards, and includes a raw cable and may include a boost device. The raw cable includes coaxial lines of a characteristic cable impedance higher than the impedance implied in the standards. The correct impedance is observed at the sending end by shunt resistors mounted in the first cable connector. The resultant loss of signal may be made up with the boost device mounted in the connector at the other end of the cable in the case of a long cable.
US08674222B2 Guiding and protecting device for cable and conduit
The present invention relates to a guiding and protecting device for a cable and conduit, comprising a pair of lateral walls being connected through a bottom plate, wherein the top surface of one of the lateral walls is connected to an end of one of a lateral edges of a restrain plate integrally, the other lateral edge is downwardly extended with a bending part, a buckle mechanism is formed between the bending part and the other lateral wall; an opened top of an accommodation slot formed by the two lateral walls is sealed by the restrain plate, and the two lateral edges of the restrain plate are respectively abutted against an inner edges of a positioning blocks protrudingly formed on the top surfaces of the two lateral walls, thereby overcoming the disadvantage of the two lateral walls being inwardly retracted and deformed, meanwhile increasing the whole structural strength.
US08674219B2 Mounting clip for electrical device
An electrical assembly includes a wiring device and an insert clip member that can be preassembled to provide quick connection to an electrical box, mud ring or other support structure having an aperture with a dimension to receive the clip member. The clip member can couple to the mounting screws of the working device and can be snapped into an aperture in a mud ring to align the screws with the threaded holes in the electrical box. The clip has a U-shape with outwardly projecting tabs that engage the aperture in the mud ring and inwardly extending tabs that engage the mounting screws of the wiring device. The tabs allow the mounting screws to be pressed into the clip in a sliding or ratcheting manner and allow the clip to snap into the aperture in the mud ring.
US08674211B1 Solar charging handbag
A solar charging handbag for recharging electronic appliances such as cellular telephones, personal digital assistants (PDAs), digital cameras, and Digital Versatile Disc (DVD) players, MP3 players, gaming stations, and similar devices. A solar panel is connected to a charge control module and the electronic appliance is plugged into the charge control module. The charge control module may incorporate a rechargeable battery or battery pack.
US08674210B2 Photoelectric conversion device and manufacturing method of the same
To provide a photoelectric conversion device having a high photoelectric conversion efficiency, a photoelectric conversion device 21 includes a substrate 1, a plurality of lower electrodes 2 on the substrate 1 comprising a metal element, a plurality of photoelectric conversion layers 33 comprising a chalcogen compound semiconductor formed on the plurality of lower electrodes 2 and separated from one another on the lower electrodes 2, a metal-chalcogen compound layer 8 comprising the metal element and a chalcogen element included in the chalcogen compound semiconductor formed between the lower electrode 2 and the photoelectric conversion layer 33, an upper electrode 5 formed on the photoelectric conversion layer 33, and a connection conductor 7 electrically connecting, in a plurality of the photoelectric conversion layers 33, the upper electrode 5 to the lower electrode 2 without interposition of the metal-chalcogen compound layer 8.
US08674209B2 Thin film type solar cell and method for manufacturing the same
A thin film type solar cell and a method for manufacturing the same is disclosed, which is capable of improving solar-ray transmittance and dispersion efficiency by the increased effective area for absorbing the solar ray through the use of substrate with a predetermined pattern having protrusions and depressions, wherein the method comprises preparing a substrate with a predetermined pattern having protrusions and depressions on its one surface; forming a front electrode on the substrate; forming a semiconductor layer on the front electrode; and forming a rear electrode on the semiconductor layer.
US08674207B1 Electronic musical instrument
The device relates to a circular electronic musical instrument having a keyboard with keys which produces polyphonic musical notes. The device is an organ which covers at least one octave of musical notes. The octaves are aligned in bands of concentric rings located on the top of the instrument. Each band of keys may contain one octave of notes. Notes in a first octave are next to or nearby identical notes in a second octave to make popular chords and songs easy to play. Notes may be played simultaneously which are octaves apart with one hand due to proximity of all the keys. A hand may extend over a centrally located loudspeaker and be used to vary the loudness and produce vibrato effects. A small overlay having information may be easily placed on the top of the keyboard to assist in learning songs by number, color, or other visual aids.
US08674206B2 Systems and methods for creating, modifying, interacting with and playing musical compositions
A method for generating music via a computing system includes providing a website coupled to a computing system. A music application is executed on the computing system. Generated music is audibly played at least in part using the computing system. As a first step musical data is provided for a complete music piece, and the musical data for the complete music piece includes one or more seed parameter values transmitted by the website that are determinative of the complete music piece and based on which the music is generated. At least one seed parameter value is processed by a pseudorandom number generator routine to generate the music.
US08674204B2 Multi task drumstick
A stick type drumstick is disclosed which includes a drumstick design featuring a hole drilled longitudinally at the striking end and an enlarged solid area positioned at the hole base. The purpose of the hole is to accommodate an insert of rods, nylon tube or a drumstick tip which when played produce different sounds. The purpose of the solid enlarged area is to provide a strong defined optional striking area, it can be struck harder to produce louder focused sounds assuring the stick area around the drilled hole is not struck and damaged which could compromise its ability to hold the insert. Striking with the area of the insert material provides additional sound possibilities. The result; combining these materials and features is a multi task drumstick. The combination of features utilized in this drumstick design cannot be found in the prior art of singular drumstick designs.
US08674201B2 Plants and seeds of hybrid corn variety CH685922
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH685922. The invention thus relates to the plants, seeds and tissue cultures of the variety CH685922, and to methods for producing a corn plant produced by crossing a corn plant of variety CH685922 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH685922.
US08674199B2 Plants and seeds of hybrid corn variety CH757483
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH757483. The invention thus relates to the plants, seeds and tissue cultures of the variety CH757483, and to methods for producing a corn plant produced by crossing a corn plant of variety CH757483 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH757483.
US08674198B2 Plants and seeds of corn variety CV960705
According to the invention, there is provided seed and plants of the corn variety designated CV960705. The invention thus relates to the plants, seeds and tissue cultures of the variety CV960705, and to methods for producing a corn plant produced by crossing a corn plant of variety CV960705 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV960705 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV960705.
US08674195B1 Maize hybrid X08C859
A novel maize variety designated X08C859 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X08C859 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X08C859 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X08C859, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X08C859. This invention further relates to methods for producing maize varieties derived from maize variety X08C859.
US08674191B2 Plants and seeds of hybrid corn variety CH027901
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH027901. The invention thus relates to the plants, seeds and tissue cultures of the variety CH027901, and to methods for producing a corn plant produced by crossing a corn plant of variety CH027901 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH027901.
US08674189B2 Plants and seeds of hybrid corn variety CH475945
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH475945. The invention thus relates to the plants, seeds and tissue cultures of the variety CH475945, and to methods for producing a corn plant produced by crossing a corn plant of variety CH475945 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH475945.
US08674185B2 Soybean variety A1026742
The invention relates to the soybean variety designated A1026742. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1026742. Also provided by the invention are tissue cultures of the soybean variety A1026742 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1026742 with itself or another soybean variety and plants produced by such methods.
US08674183B2 Soybean variety A1026009
The invention relates to the soybean variety designated A1026009. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1026009. Also provided by the invention are tissue cultures of the soybean variety A1026009 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1026009 with itself or another soybean variety and plants produced by such methods.
US08674181B2 Soybean variety XB003B12
A novel soybean variety, designated XB003B12 is provided. Also provided are the seeds of soybean variety XB003B12, cells from soybean variety XB003B12, plants of soybean XB003B12, and plant parts of soybean variety XB003B12. Methods provided include producing a soybean plant by crossing soybean variety XB003B12 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB003B12, methods for producing other soybean varieties or plant parts derived from soybean variety XB003B12, and methods of characterizing soybean variety XB003B12. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB003B12 are further provided.
US08674177B2 Precise breeding
The present invention relates to a method for identifying and isolating native plant nucleic acid sequences that may function as T-DNAs or T-DNA border-like sequences, effecting the transfer of one polynucleotide into another polynucleotide. The present invention also provides a modified tuber, such as a genetically modified mature tuber, that comprises at least one trait that is not exhibited by a non-modified tuber of the same species.
US08674175B2 Farnesene synthase
A new farnesene synthase was isolated from tomato. The farnesene synthase shows surprising properties with regard to the end products formed and its gene has, on a nucleotide level, low sequence identity with known farnesene synthase genes from other sources. The invention relates to isolated polynucleotides, polypeptides encoded by said polynucleotides, genetic constructs, vectors, hosts, in particular plants, harboring such polynucleotides, polypeptides and genetic constructs, and seed derived from such plants.
US08674174B1 Maize hybrid X00C219
A novel maize variety designated X00C219 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X00C219 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X00C219 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X00C219, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X00C219. This invention further relates to methods for producing maize varieties derived from maize variety X00C219.
US08674173B1 Maize hybrid X95C442
A novel maize variety designated X95C442 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X95C442 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X95C442 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X95C442, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X95C442. This invention further relates to methods for producing maize varieties derived from maize variety X95C442.
US08674171B2 Three-dimensional apertured film for transmitting dynamically-deposited and statically-retained fluids
A three-dimensional film for use as a transfer layer in an absorbent article has a continuous surface and a discontinuous surface disposed generally parallel to and spaced from said continuous surface; both the continuous surface and the discontinuous surface have large scale apertures defined by sidewalls originating on the surface and extending outwardly therefrom and sized to permit acquisition of fluids by gravity, and optionally each surface also includes small scale apertures sized to acquire fluids by capillary action.
US08674165B2 Adhesive injection site
A pad of elastomeric material having a softness of no more than about durometer 30 Shore 00. The pad may carry adhesive for adhering the pad to a surface, either directly or indirectly through an envelope which surrounds the pad and carries the adhesive. Such a pad exhibits hemostatic and leak prevention properties against needle puncture holes in the skin or the wall of a hollow medical device. Particularly, hemostasis may be prevented with low pressure application of the pad to the skin. The pad may be previously applied to the skin of the patient or a wall of a medical device such as tubing or a solution bag, and the needle may then penetrate both the pad and the skin or medical device wall, to make a resealable puncture with leakage reduction and hemostasis when the needle is withdrawn.
US08674163B2 DNA hybrids and environment cleaning system employing DNA hybrids
A DNA hybrid which comprises a porous oxide matrix and DNA immobilized thereon, and is useful for environmental clean-up, where the hybrid is prepared by removing a dispersion medium from a dispersion of colloidal oxide and DNA.
US08674162B2 Method for preparing ceramic waste form containing radioactive rare-earth and transuranic oxide, and ceramic waste form with enhanced density, heat-stability, and leach resistance prepared by the same
Disclosed herein is a method for preparing a ceramic waste form containing radioactive rare-earth and transuranic oxide, and the ceramic waste form with enhanced density, heat-stability, and leach resistance prepared by the same.
US08674160B2 Dewaxing of renewable diesel fuel
Feeds containing a hydrotreated biocomponent portion, and optionally a mineral portion, can be processed under catalytic conditions for isomerization and/or dewaxing. The sulfur content of the feed for dewaxing can be selected based on the hydrogenation metal used for the catalyst. Diesel fuel products with improved cold flow properties can be produced.
US08674158B2 Catalyst for hydrocarbon steam cracking, method of preparing the same and method of preparing olefin by using the same
The present invention relates to a catalyst for hydrocarbon steam cracking, a method of preparing the same, and a method of preparing olefin by the hydrocarbon steam cracking by using the catalyst, and more specifically, to a catalyst for hydrocarbon steam cracking for preparing light olefin including an oxide catalyst (0.5≦j≦120, 1≦k≦50, A is transition metal, and x is a number corresponding to the atomic values of Cr, Zr, and A and values of j and k) represented by CrZrjAkOx, wherein the composite catalyst is a type that has an outer radius r2 of 0.5R to 0.96R (where R is a radius of a cracking reaction tube), a thickness (t; r2−r1) of 2 to 6 mm, and a length h of 0.5r2 to 10r2, a method of preparing the same, and a method of preparing light olefins such as ethylene, propylene, etc., by performing the hydrocarbon steam cracking reaction in the presence of the composite catalyst. The present invention can provide catalysts for hydrocarbon steam cracking having high physical strength, excellent stability at high temperature, low non-activation due to coke, and improved yield and selectivity of light olefins.
US08674155B2 Systems and methods for processing hydrocarbons
Systems and methods for processing one or more hydrocarbons are provided. In one or more embodiments, the method can include thermally converting a hydrocarbon comprising methane to produce a first product comprising acetylene. The method can also include hydrogenating the first product to produce a second product comprising ethylene. The method can further include catalytically reacting the second product with one or more butene products to produce a third product comprising propylene.
US08674152B1 Coal liquefaction by base-catalyzed hydrolysis with CO2 capture
The one-step hydrolysis of diverse biomaterials including coal, cellulose materials such as lumber and forestry waste, non-food crop waste, lignin, vegetable oils, animal fats and other source materials used for biofuels under mild processing conditions which results in the formation of a liquid fuel product along with the recovery of a high purity CO2 product is provided.
US08674148B2 Manufacturing process for iodinated aromatic compounds
Disclosed is a method for preparing an iodinated aromatic compound. More specifically, disclosed is a method of preparing an iodinated aromatic compound by iodinating an aromatic compound in the presence of oxygen over a zeolite catalyst, in which the aromatic compound and a monoiodo analog of the aromatic compound, or a monoiodo aromatic compound, as raw materials, are allowed to react with iodine. In comparison with a method in which only the aromatic compound is used as a raw material without adding the monoiodo compound, the disclosed method can increase the productivity of diiodo compounds and the selectivity to a p-diiodo compound and, at the same time, suppress side reactions, thus lengthening the life span of the catalyst.
US08674145B2 Method for acceleration of cumene oxidation
The purpose of the present invention is to provide an advantageous method for accelerating the cumene oxidation reaction without the drawbacks of the above-described previously known approaches by utilizing one or more airlift-type tray installed in one or more conventional commercial reactors utilized during the cumene oxidation process. Such a method is of great use in process configurations where it is desirable to achieve a controlled acceleration of the cumene oxidation process without decreasing process selectivity.
US08674143B2 Synthesis of green ketone intermediate
A process for the preparation of 1-ethynyl-3,3-dimethylcyclohexan-1-ol from dimedone by a reaction sequence of reduction and ethynylation and its further transformation into green ketone.
US08674142B2 Naphthenic hydrocarbon additives for diaryl phosphide salt formation
The invention relates to the use of polycyclic aromatic hydrocarbons (PAHs) such as naphthalene and its alkyl, aryl, or heteroatom substituted analogs, that act as catalysts in the presence of an alkali metal (Li, K, Na) for the reduction of electron-deficient and electron-rich triaryl phosphines to their corresponding alkali metal diaryl phosphide salts. The process is also useful for the catalysis of triaryl phosphine chalcogen adducts such as the sulfides, oxides, and selenides, diaryl(halo)phosphines, triaryl phosphine-borane adducts, and tetra-aryl bis(phosphines) that can also be reduced to their corresponding alkali metal diaryl phosphide salts. The invention also relates to small molecule PAHs and polymer tethered PAHs naphthenics.
US08674141B2 Organic electroluminescent device and boric acid and borinic acid derivatives used therein
The present invention relates to the use of aromatic boronic acid or borinic acid derivatives in organic electronic devices, in particular electroluminescent devices.
US08674136B2 Aromatic butan-2-ol compounds and preparation and uses thereof
Aromatic butan-2-ol compounds, preparation methods for making the compounds, and uses of the compounds are provided. Specifically, the compound of Formula I, or an optical isomer, racemate, diastereomer, pharmaceutically acceptable salt, or solvate thereof, is provided, where each of the substituents is defined. In addition, a pharmaceutical composition containing the compound, and the use of the compound in manufacture of a medicament for the treatment and/or prophylaxis of a disease or disorder caused by tubercle bacillus infection, is provided.
US08674134B2 Oligomer functionalized nanotubes and composites formed therewith
Disclosed herein is a sequential functionalization methodology for the covalent modification of nanotubes with between one and four repeat units of a polymer. Covalent attachment of oligomer units to the surface of nanotubes results in oligomer units forming an organic sheath around the nanotubes, polymer-functionalized-nanotubes (P-NTs). P-NTs possess chemical functionality identical to that of the functionalizing polymer, and thus provide nanoscale scaffolds which may be readily dispersed within a monomer solution and participate in the polymerization reaction to form a polymer-nanotube/polymer composite. Formation of polymer in the presence of P-NTs leads to a uniform dispersion of nanotubes within the polymer matrix, in contrast to aggregated masses of nanotubes in the case of pristine-NTs. The covalent attachment of oligomeric units to the surface of nanotubes represents the formation of a functional nanoscale building block which can be readily dispersed and integrated within the polymer to form a novel composite material.
US08674132B2 N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.
US08674129B2 Method of making a diorganodihalosilane
A method of making a diorganodihalosilane contacting an organotrihalosilane according to the formula RSiX3 (I) with hydrogen in the presence of a metal catalyst comprising at least two metals and at a temperature from 300 to 800° C. to form a diorganodihalosilane, wherein R is C1-C10 Q hydrocarbyl, X is halo, and two of the at least two metals are chosen from at least one of (i) copper and palladium, (ii) copper and gold, (iii) indium and iridium or (iv) iridium and rhenium.
US08674123B2 Method for extracting materials and device for implementing same
The invention can be used for extraction of valuable biologically active agents from raw materials. The method of extraction comprises treating the raw materials by preliminary extraction with the extracting agent heated to the temperature not allowing denaturation of raw materials and the final product. The extracting agent is either distilled water or watered alcohol to carry out both the impregnation of raw material with the extracting agent and extraction in vacuum-impulsive mode in the extractor, to carry out catching of extract essential oils. The device for extraction comprises a screw dozer and continuous heated rolls with a vessel to receive press cake impregnated with the extracting agent, two parallel extractors, pipelines connected to a reflux condenser, a foam-destroying device, and vessels to store and prepare the extracting agent and the extract interconnected filters and condensers, additionally connected with a receiver which is equipped with a vacuum pump and pipelines.
US08674122B2 Process for preparing divinylarene dioxides
A process for preparing a divinylarene dioxide including reacting (a) at least one divinylarene; (b) at least one peroxycarboximidic acid; (c) at least one solvent; and (d) at least one basic compound, under conditions to form a reaction mixture containing a divinylarene dioxide product; and then separating the divinylarene dioxide product from the other reaction mixture components to obtain a purified divinylarene dioxide product.
US08674120B2 Process for manufacturing zeranol
This invention is directed generally to a process for producing Zeranol that eliminates high pressure and high temperature hydrogenations and provides high selectivity for Zeranol at improved yields.
US08674118B2 Compounds and methods for the treatment or prevention of flavivirus infections
Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, Y1, and Z are as defined herein, are useful for treating flaviviridae viral infections.
US08674115B2 CRTH2 modulators
Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I:
US08674113B2 Compounds
This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, L, M, W, R1, R2, R3, R4, R6, R7, R9, Ra, Rb have meanings given in the description.
US08674112B2 Polymorph of a pharmaceutical
A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.
US08674109B2 Pesticidal compositions
The present invention concerns novel heteroaryl-N-aryl carbamates and their use in pest control, as insecticides and acaricides This invention also includes preparation of the pesticide compositions containing the compounds, and methods of controlling insects using the compounds.
US08674101B2 Nucleophilic fluorination of aromatic compounds
Iodylbenzene derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are used as precursors in aromatic nucleophilic substitution reactions. The iodyl group (IO2) is regiospecifically substituted by nucleophilic fluoride to provide the corresponding fluoroaryl derivatives. No-carrier-added [F-18]fluoride ion derived from anhydrous [F-18](F/Kryptofix, [F-18]CsF or a quaternary ammonium fluoride (e.g., Me4NF, Et4NF, n-Bu4NF, (PhCH2)4NF) exclusively substitutes the iodyl moiety in these derivatives and provides high specific activity F-18 labeled fluoroaryl analogs. Iodyl derivatives of a benzothiazole analog and 6-iodyl-L-dopa derivatives have been synthesized as precursors and have been used in the preparation of no-carrier-added [F-18]fluorobenzothiazole as well as 6-[F-18]fluoro-L-dopa.
US08674099B2 Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors
The invention relates to compounds of formula (I) wherein the substituents are as defined in the specification, in free form or in the form of a pharmaceutically acceptable salt, solvate, ester, N-oxide thereof; processes for the preparation thereof; to pharmaceuticals containing such compounds, in particular for the use in one or more Protein tyrosine kinase mediated diseases.
US08674096B2 Substituted imidazo[1,5-a]quinoxalin-4-ones as phosphodiesterase 9 inhibitors
Substituted imidazo[1,5-a]quinoxalin-4-ones are useful as phosphodiesterase 9 inhibitors.
US08674093B2 Process for the preparation of an orexin receptor antagonist
The present invention is directed to processes for preparing a pyridyl piperidine compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved.
US08674089B2 Michael addition reaction product and active energy ray-curable composition
The present invention provides a Michael addition reaction product between a specified compound having a group which functions as a Michael donor and a monomer or polymer having a group which functions as a Michael acceptor, a photoinitiator containing the Michael addition reaction product, and an active energy ray-curable composition containing the photoinitiator. The compound having a group functioning as a Michael donor used in the present invention is a phenyl ketone derivative and is characterized by having an amino group or a mercapto group as the group functioning as a Michael donor.
US08674087B2 Processes for isolation and purification of enfumafungin
The present disclosure relates to processes useful in the isolation and purification of enfumafungin, which is classified as a triterpene glycoside antifungal compound and acts as a glucan synthase inhibitor. Enfumafungin has application in the treatment of conditions caused by fungal infection and is also useful as an intermediate in the preparation of other compounds useful as antifungal agents and/or inhibitors of (1,3)-β-D-glucan synthesis.
US08674079B2 Cancer cell migration and cancer cell invasion inhibitor
Provided are an antibody which binds specifically PAR1 (protease activated receptor 1) or a fragment of the antibody which retains similar characteristics thereto; a composition containing the same for inhibiting the migration activity and invasion activity of cancer cells; and a medicinal composition for treating cancer and the like.
US08674075B2 Chimeric peptides for the regulation of GTPases
Chimeric peptides or fusion proteins are disclosed that include a RhoGAP activity domain and at least one specificity domain that targets a specific Rho protein. The fusion proteins can be used to inhibit any GTPase activity within a cell. The fusion proteins are particularly advantageous for the treatment of cancer. The present invention generally relates to chimeric peptides capable of regulating GTPases, and more particularly, to methods of targeting individual GTPases by using GTPase-activating proteins. Such proteins may be used for the treatment of cancers and other GTPase-related diseases. This invention relates to nucleic acid molecules and the encoded GTPase activating proteins, and variants thereof, and to the use of these molecules in the characterization, diagnosis, prevention, and treatment of cell signaling, immune, and cell proliferative disorders, particularly cancer. Disclosed herein are compounds and methods for regulating transcription of a selected gene.
US08674073B2 Immunoglobulin affinity ligand
Provided is affinity chromatography carrier for an immunoglobulin that simultaneously has high immunoglobulin-binding capability and chemical stability and that can be produced at low cost. An immunoglobulin-binding protein in which an amino acid substitution for not only maximizing the number of lysine residues on the protein surface of helix 3 and its periphery but also minimizing the number of lysine residues present on the protein surfaces of helix 1 and helix 2 as immunoglobulin-binding regions and/or an amino acid substitution for eliminating an aspartic acid-proline sequence have (has) been carried out, or a multimer thereof, is used as an affinity ligand for an affinity chromatography carrier.
US08674071B2 Peptides that target dorsal root ganglion neurons
The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (DRG) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example. In particular cases, the peripheral neuropathies or neuropathic pain is caused directly or indirectly by DRG neuronopathy.
US08674067B2 Peptide capable for binding to iridium
The present invention provides a novel peptide capable for binding to iridium. The peptide consists of an amino acid sequence represented by SQMMGHMGHGNMNHMNHGGKFDFHH (SEQ ID NO: 01).
US08674062B2 Cell culture compositions
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl6 (SEQ ID NO:1 encodes the full length endoglucanase; SEQ ID NO:4 encodes the mature form), and the corresponding endoglucanase VI amino acid sequence (“EGVI”; SEQ ID NO:3 is the signal sequence; SEQ ID NO:2 is the mature sequence). The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVI, recombinant EGVI proteins and methods for producing the same.
US08674061B2 Multiligand constructs
Multiligand constructs and intermediate multivalent constructs for use in their preparation. The multiligand constructs have utility in diagnostic and therapeutic applications.
US08674050B2 Reactive isocyanate compositions
The invention relates to compositions with isocyanate groups, which can be cured without an isocyanate-reactive component, to processes for preparing such compositions and to the use thereof.
US08674049B1 Silicone containing aromatic film forming polymers
The present invention is directed to polymers that are useful in nail polish applications. The specific film forming polyester polymers that are liquids in solvents like butyl acetate, form a uniform film upon application when in a solvent (most commonly butyl acetate), evaporates under atmospheric conditions and at the same time can be removed easily and thoroughly by application of a solvent like acetone. The polymers of the present invention having a silicone portion contained therein provide improved flexibility, tear resistance and superior aesthetics.
US08674044B2 Immobilization of membrane proteins onto supports via an amphiphile
The invention pertains to the field of membrane protein immobilization onto supports. It relates to a product comprising a support and at least one membrane protein attached to the surface thereof, characterized in that said membrane protein is attached to said support using an amphiphilic molecule with which said membrane protein is complexed. It also relates to a process for preparing such product, as well as to various applications in the fields of diagnosis, drug design and biotechnologies. It further relates to a kit, together with a functionalized amphiphilic molecule, for preparing a product according to the invention comprising a support and an amphiphilic molecule, wherein the amphiphilic molecule and the support interact through a hydrophobic bond, an ionic bond, a specific bond or a covalent bond.
US08674043B2 Photosensitive resin composition containing copolymer
There is provided a photosensitive resin composition having desired properties. A photosensitive resin composition comprising: a component (A) that is a copolymer including a structural unit of Formula (1) and at least one structural unit of Formula (2), and a component (B) that is a photosensitizer: (where two Xs are independently a hydrogen atom, a C1-5 alkyl group, a C5-6 cycloalkyl group, a phenyl group, or a benzyl group and Y is a hydrogen atom, a C1-5 alkyl group, a C5-6 cycloalkyl group, a phenyl group, or a benzyl group provided that each of a part or all of the hydrogen atoms in the alkyl group, the cycloalkyl group, the phenyl group, and the benzyl group is optionally substituted with a halogen atom, a carboxy group, a hydroxy group, an amino group, or a nitro group).
US08674036B2 Hair cosmetic
A hair cosmetic composition comprising components (A) and (B) at a mass ratio of (A)/(B)=0.66 to 9.0: (A) an organopolysiloxane wherein poly(acylalkyleneimine) segments each having a molecular weight of from 1,200 to 5,500 are bound to an organopolysiloxane segment having a molecular weight of from 7,000 to 100,000, the mass ratio of the both segments is from 35/65 to 60/40, and the organopolysiloxane segment between the above-mentioned bonds has a molecular weight of from 1,300 to 5,500, (B) an organopolysiloxane wherein poly(acylalkyleneimine) segments each having a molecular weight of from 800 to 1,600 are bound to an organopolysiloxane segment having a molecular weight of from 10,000 to 100,000, the mass ratio of the both segments is from 65/35 to 82/18, and the organopolysiloxane segment between the above-mentioned bonds has a molecular weight of from 1,500 to 3,500.
US08674035B2 Biostable polyurethanes
The present invention relates to a biostable polyurethane or polyurea comprising: (a) a soft segment comprising a polysiloxane of the general formula (I); and (b) greater than O and less than 40 wt % of a hard segment which is a reaction product of a diisocyanate and a linear difunctional chain extender, processes for their preparation and their use in the manufacture of biomaterials, devices, articles or implants.
US08674027B2 Powdered thermoplastic polyolefin elastomer composition for slush molding processes
The present invention relates to a thermoplastic polyolefin elastomer composition in powder form comprising (i) an olefin block copolymer or (ii) a substantially linear ethylene polymer and/or a linear ethylene polymer and propylene polymer blend. Said composition demonstrates good pulverizing and flow characteristics at ambient temperature. In another aspect, this invention relates to a process for preparing said thermoplastic polyolefin elastomer powder and applications for using said powder. In a further aspect, this invention relates to slush molding said thermoplastic polyolefin elastomer composition into skins, particularly skins for automotive interior applications such as instrument panels.
US08674020B2 Process for preparing polyamides
There is provided a novel process for preparing polyamides (in particular cyclic and hairpin polyamides) comprising the step of coupling an amine with a Boc-protected amino acid monomer in the presence of diphosgene and/or triphosgene. Such a process may be performed on a solid or solution phase.
US08674018B2 Binder and process for producing metallic or ceramic moldings in powder injection molding
The invention relates to binders for pulverulent metals, metal alloys or ceramics based on polyacetals, polyethers and polyesters, to thermoplastic compositions comprising these binders for the production of metallic or ceramic moldings, to the use thereof and to processes for production of moldings therefrom.
US08674009B2 Process for controlling the scorch time (ST) in the vulcanization of silicic acid-filled rubber blends
A process for controlling the scorch time (ST) in the vulcanization of vulcanizable blends containing a composition to be vulcanized, hydrophobized silicic acid and zinc oxide particles wherein the scorch time control is effected by the size and number of zinc oxide particles (amount). The process of the invention is also suitable for preparing vulcanized rubber articles.
US08674006B2 Black pigment dispersion
Described is a pigment dispersion which is useful for electrophoretic displays comprising α) a bis-oxodihydro-indolylene-benzodifuranone colorant of the Formula (I) wherein the substituents are defined as in claim 1, β) a specific polymeric dispersant, and γ) a solvent which is suitable for dispersions used in electrophoretic displays. Also described are novel colourants and dispersants.
US08674004B2 Rubber composition, method for its formation, and automotive tire containing the composition
A rubber composition with disperse phase particles containing poly(phenylene ether) can be formed by a method that includes melt blending an uncured rubber with a poly(phenylene ether) composition containing a poly(phenylene ether) and an oil to form an uncured rubber composition, then curing the uncured rubber composition. Before being blended with the rubber, the poly(phenylene ether) composition exhibits a glass transition temperature of about 40 to about 140° C., and during blending with the rubber, the oil component of poly(phenylene ether) composition migrates from the poly(phenylene ether) composition to the rubber, leaving a poly(phenylene ether)-containing disperse phase that gives rise to a second hysteresis peak temperature of about 160 to about 220° C. as measured by dynamic mechanical analysis of the cured rubber composition. Also described are the poly(phenylene ether) composition used in the method, a cured rubber composition formed by the method, and a tire containing the cured rubber composition.
US08674000B2 Multi-layered paper coating latex having high swelling and contraction property, method for preparing the same, and paper coating composition containing the same
Disclosed are paper coating latex, a method for preparing the same, and paper coating composition containing the same, characterized in that in the paper coating latex having a core-shell structure, the core is formed by the polymerization of monomer mixtures comprising 5 to 10 weight parts of ethylene unsaturated acid based on 100 weight parts of the core, wherein the amount of ethylene unsaturated acid in the shell is less than that in the core, and the shell has glass transition temperature up to room temperature, lower than that of the core. The present invention has an effect of providing a high quality matte coated paper that has excellent printability such as ink drying rate, adhesion, etc., as well as low white paper gloss and improved print gloss by coating paper coating composition containing multi-layered paper coating latex having high swelling and contraction property on paper.
US08673996B2 UV curable anhydride-modified poly(isobutylene)
An adhesive (co)polymers comprising: a) an isobutylene copolymer having pendent anhydride groups, b) a polyamine photobase generator and c) optionally a tackifier is described.
US08673989B2 Method of devulcanizing a cross-linked elastomeric material
A thermoset cross-linked elastomer material, such as scrap tire rubber, is devulcanized by subjecting the material to a mechanical mixing process in the presence of 0.5 to 2% by wt. of an organic catalyst having a thiol terminus.
US08673987B2 Surfactant composition
A surfactant composition contains at least one sorbitan ester and at least one sorbitol ester wherein the mean number of carbon atoms of the hydrophobe of the sorbitan ester is greater than that of the sorbitol ester. The surfactant composition is particularly suitable for use in stabilizing emulsions, especially personal care or cosmetic products.
US08673982B2 Ceramide-analogous metabolites
This invention relates to certain ceramide-analogues of FTY720 (2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol; fingolimod). In particular, the present invention relates to pharmaceutical compositions comprising these compounds, as well as processes for their preparation and their use in the treatment of autoimmune conditions, such as multiple sclerosis.
US08673981B2 Phenylcyclobutylamide derivatives and their stereoisomers, the preparation processes and uses thereof
Phenylcyclobutylamide derivatives and their optical isomers, the preparing processes and the uses thereof, which includes the compounds of formula (I), their pure stereoisomers and their pharmaceutically acceptable salts. In formula (I), R is H, formacyl, acetyl, haloacetyl, benzoyl, benzyloxy carbonyl (Cbz), t-butoxy carbonyl (Boc), or 9-fluorenyl methoxyl carbonyl (Fmoc). The present novel compounds have pharmaceutical activity and are prepared by condensation reaction of racemic, levo- or dextro-demethyl Sibutramine and racemic or D/L isoleucine under a mild condition. It is demonstrated that the present compounds have effect of losing weight to obese mode rats in different level and the effect is better than Sibutramine by the animal experiments. So the medicaments prepared by the present compounds or the medicaments prepared by the compositions of the present compounds and other pharmaceutical activity compounds may be used for treating obesity.
US08673976B2 Medicament for prophylactic and/or therapeutic treatment of hepatic steatosis or non-alcoholic steatohepatitis
A medicament for prophylactic and/or therapeutic treatment of hepatic steatosis or non-alcoholic steatohepatitis, which comprises a polyprenyl compound (e.g., 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid) as an active ingredient.
US08673974B2 Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, A1, X, X1, s and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of the compounds of the invention and a combination of pharmacologically active agents and a compound of the invention.
US08673970B2 HIV protease inhibitor and cytochrome p450 inhibitor combinations
Compositions and methods of treating viral infections are provided. More particularly, compositions including a combination of protease inhibitors and cytochrome p450 enzyme inhibitors are provided. Methods of using the compositions for treatment of diseases or disorders caused by a virus such as HIV infections are also provided.
US08673965B2 Composition for the treatment of arthritis containing a dibenzo-p-dioxin derivative as the active ingredient
Disclosed is a composition for treating arthritis containing a dibenzo-p-dioxin derivative as an active ingredient. This dibenzo-p-dioxin derivative is very effective in inhibiting NF-kB and AP-1 activity, alleviates the symptoms of degenerative arthritis and rheumatoid arthritis without irritating the skin or causing side effects, and can continue to exhibit improvement effects for a considerable period of time after discontinuation of treatment. Additionally, when the dibenzo-p-dioxin derivative is contained in liposomes, the composition of the invention exhibits much greater effects on treating arthritis by absorption through skin, and thus is useful for the treatment of degenerative arthritis and rheumatoid arthritis.
US08673963B2 Method for producing cyclic sulfonic acid ester and intermediate thereof
The present invention is directed to provide an efficient production method which is capable of not only obtaining a cyclic sulfonic acid ester (sultone) at low cost and in high yield, but also the sulfonic acid ester (sultone) stably even in a commercial scale. The present invention relates to a method for producing hydroxysultone comprising a first step where a diol having a specified structure and a thionyl halide are reacted to obtain a cyclic sulfite having a specified structure, and a second step where the cyclic sulfite is reacted with water or/and alcohol; a method for producing an unsaturated sultone having a specified structure comprising a third step where a hydroxylsultone having a specified structure is reacted with an acid halide or an acid anhydride to obtain an intermediate, subsequently the intermediate is treated with a base; as well as a cyclic sulfite having a specified structure.
US08673958B2 Fullerene derivatives
A fullerene derivative having a partial structure represented by formula (1): wherein R represents a monovalent group, and r represents an integer of 0 to 4, in particular, a fullerene derivative, which has one to four structures represented by formula (1), can be applied to an organic photoelectric conversion element having a high open-circuit voltage and is therefore suitable for an organic thin-film solar cell or an organic photosensor, and thus it is extremely useful.
US08673956B2 Imido-acid salts and methods of use
Imido-acid salts and compositions containing imido-acid salts are described herein. Methods of their preparation and use are also described herein. The methods of using the imido-acid salts include the reduction of volatile compounds from gas and liquid streams and the delivery of pharmaceutical agents to subjects.
US08673949B2 Use of epothilone D in treating Tau-associated diseases including Alzheimer's disease
Methods of treating Tau-associated diseases, preferably tauopathies, are described using epothilone D that exhibit good brain penetration, long half-life, and high selective retention in brain, and provides effective therapies in treating tauopathies including Alzheimer's disease.
US08673946B2 4-trimethylammonio-butyrates as CPT2 inhibitors
This invention relates to novel 4-trimethylammoniobutyrates of the formula wherein A1, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments.
US08673944B2 Solid pharmaceutical composition comprising amlodipine and losartan with improved stability
The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising granular forms of amlodipine and losartan which are separated from each other, and a stabilizing agent, which has improved storage stability due to minimized interaction between amlodipine and losartan.
US08673941B2 Oxazole derivatives useful as inhibitors of FAAH
The present invention is directed to certain oxazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer Disease, and Parkinson's Disease.
US08673933B2 JAK2 inhibitors and their use for the treatment of myeloproliferative diseases and cancer
The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK2, thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
US08673932B2 Oxime substituted imidazo-containing compounds
Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
US08673930B2 Pyrimidylaminobenzamide derivatives for systemic mastocytosis
The present invention relates to the use of pyrimidylaminobenzamide derivatives for the preparation of a drug for the treatment of systemic mastocytosis.
US08673928B2 Compounds and methods for kinase modulation, and indications therefor
and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds of Formula (I) or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one Raf protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of B-Raf V600E mutant protein kinase, including melanoma, glioma, glioblastoma multiforme, pilocytic astrocytoma, colorectal cancer, thyroid cancer, lung cancer, ovarian cancer, prostate cancer, liver cancer, gallbladder cancer, gastrointestinal stromal tumors, biliary tract cancer, and cholangiocarcinoma. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of c-Raf-1 protein kinase, including acute pain, chronic pain or polycystic kidney disease.
US08673927B2 Uses of DPP-IV inhibitors
The specification describes the use of selected DPP IV inhibitors for the treatment of physiological functional disorders and for reducing the risk of the occurrence of such functional disorders in at-risk patient groups. In addition, the use of the above-mentioned DPP IV inhibitors in conjunction with other active substances is described, by means of which improved treatment outcomes can be achieved. These applications may be used to prepare corresponding medicaments.
US08673923B2 Small molecule trail gene induction by normal and tumor cells as an anticancer therapy
Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
US08673919B2 Dihydropyridin sulfonamides and dihydropyridin sulfamides as MEK inhibitors
This invention concerns N-(ortho phenylamino dihydropyridyl)sulfonamides and N-(ortho phenylamino dihydropyridyl), N′-alkyl sulfamides which are inhibitors of MEK and are useful in the treatment of cancer and other hyperproliferative diseases.
US08673915B2 P 2×4 receptor antagonist
A compound having the following formula (II) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist: wherein each of R11 and R12 is hydrogen, C1-8 alkyl or the like; R13 is hydrogen, C1-8 alkyl or the like; R14 is hydrogen, C1-8 alkyl, C1-8 alkoxy, C1-8 alkyl having 1-3 halogens, C1-8 hydroxyalkyl, halogen, hydroxyl, nitro, cyano, amino, C1-8 alkylamino, benzenesulfonylamino optionally having a substituent, a heterocyclic group optionally having a substituent or the like; and the condensed ring consisting of W1 and the neighboring benzene ring is naphthalene, tetrahydronaphthalene, or indan ring.
US08673909B2 Indole compounds and methods for treating visceral pain
The invention features methods of treating visceral pain or a condition in a mammal caused by the action of nitric oxide synthase (NOS) or by the action of serotonin 5HT1D/1B receptors, by administering to a patient in need thereof a therapeutically effective amount of an indole compound of Formula (I), or a pharmaceutically acceptable salt or prodrug thereof. The methods of the invention may further comprise the administration of additional therapeutic agent. The invention also features new compounds of Formula (I), pharmaceutical compositions thereof, and methods of resolving enantiomeric mixtures.
US08673907B2 Pharmaceutically acceptable salts of methyl (3-{ [[3-(6-amino- 2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl) propyl] (3-morpholin-4-ylpropyl) amino] methyl }phenyl) acetate and their use in therapy
The present invention concerns hydrochloric acid, hydrobromic acid and maleic acid salts of methyl (3-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-morpholin-4-ylpropyl)amino]methyl}phenyl)acetate, compositions comprising them and their use in therapy.
US08673906B2 Chromenone derivatives
The invention concerns chromenone derivatives of Formula I or a pharmaceutically-acceptable salts thereof, wherein each of R1, R2, R3, R4, R5, R6, R7, R8, n and R9 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.
US08673896B2 Benzodiazepine and pyridodiazepine derivatives
The present application relates to benzodiazepine and pyridodiazepine derivatives of formula (I) wherein R1, R2, R3, R4, X1, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
US08673889B2 BLT2-mediated disease, BLT2 binding agent and the compound
[PROBLEM] The compound that selectively binds to BLT2 and the preventive and/or therapeutic drug for BLT2-mediated disease such as skin disease are needed.[MEANS FOR SOLVING THE PROBLEMS] The present invention provides the compound with BLT2 binding activity, salt thereof, solvate thereof or prodrug thereof. Since the compound with BLT2 binding activity, particularly the compound represented by the formula (I), salt thereof, solvate thereof or prodrug thereof (symbols in formula have the same meanings as specification.) have BLT2 binding activity, it is useful for prevention and/or therapy of BLT2 mediated diseases, e.g., dermatosis, intestinal disease, HIV infection, acquired immunodeficiency syndrome, rejection to transplant, transplant rejection, graft-versus-host disease, autoimmune disease, allergic disease, inflammation, infection, ulcers, lymphoma, malignant tumor, leucaemia, arterial sclerosis, hepatitis, hepatic cirrhosis or cancer, etc.
US08673883B2 Pantothenate derivatives for the treatment of neurologic disorders
The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.
US08673882B2 Inhibitors of autotaxin
Stabilized benzyl phosphonic acid and naphthyl phosphonic acid analog compounds are effective in inhibiting the activity of autotaxin.
US08673881B2 Compositions and methods for the treatment of inflammation
The invention relates to novel resolvin compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel resolvin compounds of the invention.
US08673880B2 Prevention and/or treatment of neurodegenerative disorders
A pharmaceutical composition for use in the prevention and/or treatment of a neurodegenerative disorder comprising a compound comprised of one or more disaccharide units, the or each disaccharide unit comprising a uronate moiety linked to a glucosamine moiety, wherein the 2-O atom of the uronate moiety is substituted with a hydrogen atom, the 6-O atom of the glucosamine moiety is substituted with a sulphate group and the 2-N atom of the glucosamine moiety is substituted with an atom or group other than a sulphate group. The composition is particularly preferred for use in the prevention and/or treatment of Alzheimer's disease.
US08673875B2 Method for treating atherosclerosis
The invention provides a method for treating atherosclerosis in a subject in need thereof, including administering an effective amount of microRNA-195 to the subject in need thereof. The microRNA-195 may be packaged in a pharmaceutically acceptable carrier. Moreover, the pharmaceutically acceptable carrier may includes a liposome, lipid particle or viral vector.
US08673873B1 RNAi-mediated inhibition of phosphodiesterase type 4 for treatment of cAMP-related ocular disorders
RNA interference is provided for inhibition of phosphodiesterase type 4 mRNA expression for treating patients with a cAMP-related ocular disorder. Phosphodiesterase type 4 mRNA targets include mRNA for 4A, 4B, 4C, and 4D phosphodiesterase isoforms.
US08673872B2 Method of modulation of expression of epidermal growth factor receptor(EGFR) involving miRNA
The present invention relates to a method for modulating the expression of epidermal growth factor receptor (EGFR) and its downstream signalling effectors. In particular, the present invention relates to a method for modulating the expression of epidermal growth factor receptor (EGFR) or like molecule in a cell comprising contacting said cell with an agent capable of directly or indirectly interacting with the 3′-untranslated region (UTR) of the mRNA of said EGFR or like molecule, wherein the UTR is encoded by a sequence which comprises a sequence having at least about 70% identity with at least one sequence selected from the group consisting of the sequences set forth in SEQ ID NOs: 1-36.
US08673870B2 Combined DNA vaccine and biological modifiers for cancer therapy
The present invention relates to the combination of a DNA vaccination strategy that makes use of a nucleic acid encoding an immunogenic polypeptide, with a non-immunosuppressive inducer of tumor cell differentiation and/or apoptosis or a tumor cell modifier, useful for cancer therapy. Vaccine compositions and kits are provided, as well as specific nucleic acid constructs that are particularly suitable for the preparation of such compositions.
US08673863B2 Glutathione-based delivery system
A delivery system is provided. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid derivative, a polyethylene glycol (PEG) or a polyethylene glycol derivative bonded thereto, and a glutathione (GSH) or a glutathione derivative bonded to the polyethylene glycol or the polyethylene glycol derivative.
US08673861B2 Tissue protective peptides and uses thereof
Provided herein are tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are generally located on or within the region of the cytokine receptor ligand that faces away from a receptor complex while the ligand is bound to the receptor. Also provide herein are fragments, chimeras, as well as peptides designed to mimic the spatial localization of key amino acid residues within the tissue protective receptor ligands, e.g., EPO; methods for treating or preventing a disease or disorder using tissue protective peptides; and methods for enhancing excitable tissue function using tissue protective peptides.
US08673855B2 Phosphatidylinositol 3-kinases activity regulator including the fifth zinc finger domain of FOG2
The present invention relates to a phosphatidylinositol 3-kinases activity regulator which include the fifth zinc finger domain of FOG2 and which, more specifically, can induce cancer cells to die due to the inclusion of the fifth zinc finger domain of FOG2. Since the death of cancer cells is induced by suppressing the transfer of PI3K signals, the fifth zinc finger domain of FOG2 according to the present invention can be suitably use as a composition for the prevention and treatment of PI3K-related diseases.
US08673854B2 Prophylactic agent for heart failure
The present invention provides an agent having a suppressive action against the thickening of the heart wall, a prophylactic agent for heart failure containing the above described agent, and functional foods expected to have a prophylactic effect for heart failure. The agent for suppressing heart wall thickening comprises Xaa Pro Pro as an active ingredient.
US08673852B2 Methods of treating neuronal disorders using MNTF peptides and analogs thereof
The present disclosure relates to methods for treating neuronal disorders using a motoneuronotrophic factor (MNTF) or its peptide analogs. The present disclosure further relates to methods for treating a spinal cord injury, a neurodegenerative disease, a stroke or cerebral ischemia, Huntington's Disease, Parkinson's Disease, Multiple Sclerosis, amyotrophic lateral sclerosis (ALS), Alzheimer's Disease, and diabetic neuropathy in a subject by administration of motoneuronotrophic factor (MNTF) or its peptide analogs.
US08673851B2 Synapse-specific proteins in glomeruli
The present invention identifies that glomeruli express many neuron-specific and especially synapse-specific protein similarities. In particular, the present invention identifies Rab3A expression, including the expression of altered forms, as well as expression of other synapse-specific proteins including neurotransmitter receptors. The invention further identifies that modulation of the activity of these synapse-specific proteins results in modulation of podocytes.
US08673848B2 Synthetic apelin mimetics for the treatment of heart failure
The invention provides a synthetic polypeptide of Formula I′: or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
US08673841B2 Oxytocin analogues
The present invention relates to novel compounds, pharmaceutical compositions comprising the same, use of said compounds for the manufacture of a medicament for treatment of inter alia compromised lactation conditions as well as to a method for treatment of said conditions, wherein said compounds are administered. The compounds are represented by the general formula (I), as further defined in the specification.
US08673840B2 Methods for growing tissue with Lopap-based pharmaceutical compositions
The invention refers to pharmaceutical compositions and cosmetic compositions comprising a prophylactic or therapeutically effective quantity of at least one polypeptide substantially identical to Lopap (a lipocalin-related protein with prothrombin activating protease activity). The invention refers to the use of these compositions as modulators of cell death and anti-aging agents.
US08673834B2 Method and composition to remove iron and iron sulfide compounds from pipeline networks
The present invention comprises an iron complexing mixture and method of using same wherein beneficial performance and natural gas pipeline cleaning methods are employed. The synergistic improvement of combining two water-soluble metal complexing agents, THPS and IDS, prove to offer advantages in performance over the individual use of either chemical.
US08673831B2 Engine lubricants
An engine lubricant, especially an SAE OW engine lubricant is described. The engine lubricant has at least 15 wt % of at least one monoester and not more than 15 wt % of additives, wherein said at least one monoester, or mixture of said monoesters if more than one is present, has a kinematic viscosity at 100° C. of not more than 3.3, a viscosity index of at least 130 and a Noack evaporation loss of not more than 15 wt %. The monoester is preferably the reaction product of a monohydric alcohol and a monocarboxylic acid wherein said monohydric alcohol is at least one saturated branched-chain aliphatic monohydric alcohol having between 16 and 36, carbon atoms and wherein said monocarboxylic acid is at least one saturated straight-chain aliphatic monocarboxylic acid having between 5 and 10, preferably 5 and 7, carbon atoms. In preferred lubricants, the monoester, or mixtures of monoesters, have a pour point of not more than −30° C. and a non-polarity index of at least 80.
US08673830B2 Grease composition and direct-acting devices with the grease composition
A grease composition includes: a poly-α-olefin having a kinematic viscosity at 40 degrees C. of 60 to 320 mm2/s, the poly-α-olefin being contained in an amount of 50 mass % or more relative to a whole composition; a thickener that is a lithium salt of a hydroxyl-free fatty acid having 10 to 22 carbon atoms; and an ashless dithiocarbamate and/or zinc dithiocarbamate that are contained in an amount of 0.1 to 1.5 mass % in terms of sulfur relative to a whole composition. In the grease composition, a phosphorous content is 0.05 mass % or less relative to the whole composition, and a worked penetration is in a range from 265 to 310.
US08673829B2 Grease composition and grease composition-enclosed rolling bearing and universal joint
It is an object of the present invention to provide a grease composition (7) which can be used for a long term in a wide temperature range from low to high temperatures by using comparatively inexpensive base oil. It is another object of the present invention to provide a rolling bearing and a universal joint in which the grease composition (7) is enclosed. The grease composition (7) is composed of base grease, consisting of base oil and a thickener, to which an additive is added. The base oil contains not less than 50 wt % of highly refined oil having a viscosity index of 120 to 180. The additive contains at least ZnDTP and 0.2 to 6 parts by weight of poly (metha) acrylate having a kinematic viscosity of not less than 100 mm2/s and less than 850 mm2/s at 100° C. for 100 parts by weight of the base grease. The grease composition (7) is enclosed in the circumferences of rolling elements (4) of a rolling bearing (1).
US08673827B1 Method of analysis of polymerizable monomeric species in a complex mixture
Method of selective quantitation of a polymerizable monomeric species in a well spacer fluid, said method comprising the steps of adding at least one solvent having a refractive index of less than about 1.33 to a sample of the complex mixture to produce a solvent phase, and measuring the refractive index of the solvent phase.
US08673826B2 Dry blend fracturing fluid additives
A method and composition for crosslinking a polymer based fluid includes providing a dry blend of crosslinker and delay agent. The crosslinker and delay agent are mixed and granulated in a dry form prior to addition to the polymer fluid.
US08673823B2 Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia
The present invention relates to a method of identifying a compound involved in pain, the use of Epsti1 nucleic acid or Epsti1 protein for identifying a compound involved in pain as well as methods of diagnosing algesia involving the same.
US08673822B2 Rapid screening method of translational fusion partners for producing recombinant proteins and translational fusion partners screened therefrom
Disclosed are a method for rapid screening suitable translational fusion partners (TFPs) capable of inducing expression or secretory production of non-producible proteins, which are difficult to produce in conventional recombinant production methods, from a variety of genetic sources, and protein secretion-inducing TFPs obtained using the method.
US08673821B2 Coated conductor with improved grain orientation
A coated conductor comprising an improved buffer layer architecture where the buffer layers are obtainable by chemical solution deposition and where the buffer layers essentially adopt the degree of texture of the substrate.
US08673819B2 Surfactant blends useful in agriculture
The present invention teaches a surfactant blend composition of at least one nonionic alkoxylate and at least one sugar-based surfactant, and its use as an adjuvant for pesticides. The pesticidal composition employing the surfactant blend composition of the invention realizes an efficacy that is unexpectedly superior to similar pesticidal compositions which employ only the individual surfactant components. The composition of the present invention is useful as a tank side additive, or as a component in herbicidal formulations. In addition the compositions of the present invention are useful as adjuvants for other pesticides, such as, fungicides, insecticides, plant growth regulators, acaracides and the like.
US08673818B2 C2-phenyl-substituted cyclic ketonols
The present invention relates to novel C2-phenyl-substituted cyclic ketoenols of the formula in which W is methyl, X is alkyl, alkenyl or alkinyl, Y is hydrogen, methyl, ethyl, i-propyl, alkenyl or alkinyl, and Z is hydrogen, alkyl, alkenyl or alkinyl, with the proviso that at least one of X, Y, or Z represents a chain having at least two carbon atoms and with the further proviso that X is not ethyl when Z is hydrogen and Y is methyl, and CKE represents the group in which B is hydrogen, alkyl or alkoxyalkyl, A and Q1 together are optionally substituted alkanediyl or alkenediyl, Q2 is represents hydrogen or C1-C4-alkyl, and G represents hydrogen or an acyl or acyl-like group, to a plurality of processes for their preparation and to their use as pesticides and herbicides.
US08673816B2 Surfactants in agrochemical formulations
Surfactant compounds which include an amine ended polyalkylene glycol hydrophile linked to C22 to C60 mainly hydrocarbyl, particularly composite hydrocarbyl, especially derived from a polymerised fatty acid and/or an aralkyl substituted phenol, hydrophobe, are useful in dispersing solids, particularly active agrochemicals, in aqueous media, or as adjuvants in agrochemical formulations, particularly of water soluble non-selective herbicides. In particular the hydrophobe is derived from polymerised fatty acids, such as dimer and, especially, trimer acids or from aralkyl substituted phenols. Aqueous dispersions using such surfactants can remain stable even with substantial concentrations of electrolyte e.g. in stable agrochemical dispersions including water soluble electrolyte agrochemical, such as glyphosate and/or ammonium sulphate.
US08673811B2 System, methods and materials for storing and retrieving hydrogen
A system for storing and retrieving elemental hydrogen. The system includes a housing, a hydrogen storage element enclosed within the housing and having a solid-state hydrogen storage material, and a control system for regulating storage of hydrogen into and retrieval of hydrogen from the storage material. At least a portion of the storage material is a porous matrix material having atoms of a first element capable of bonding with more than one hydrogen atom per atom of the first element, and atoms of a second element capable of molecularly bonding to atoms of the first element and hydrogen. Different atoms of the first element have bond sites available for different numbers of hydrogen atoms at different levels of bonding energy. The atoms of the second element are bonded to those atoms of the first element having bond sites for more than one hydrogen atom.
US08673806B2 Catalyst on silica clad alumina support
The invention concerns catalysts comprising (i) a cladded catalyst support comprising (a) a core which comprises alumina particles and (b) about 1 to about 40 weight percent silica cladding, based on the weight of the cladded catalyst support, on the surface of the core; the catalyst support having a BET surface area of greater than 20 m2/g and a porosity of at least about 0.2 cc/g; and (ii) 0.1 to 10 weight percent, based on the weight of the catalyst, of catalytically active transition metal on the surface of the cladded catalyst support; wherein the catalyst support has a normalized sulfur uptake (NSU) of up to 25 ?g/m2. The invention also concerns the production and use of such catalysts.
US08673804B2 Enhancing catalytic activity of nanoporous materials
The present invention relates to the use of atomic layer deposition (ALD) techniques to enhance the acid catalytic activity of nanoporous materials.
US08673798B2 Dielectric ceramic and laminated ceramic capacitor
A dielectric ceramic and a laminated ceramic capacitor using the dielectric ceramic are achieved which provide favorable thermal shock resistance without damaging properties or characteristics such as dielectric properties, insulation properties, temperature characteristics, and characteristics in high temperature loading, even when the dielectric layers are reduced in thickness and the number of stacked layers increased. The dielectric ceramic contains, as its main constituent, a barium titanate based compound represented by the general formula ABO3, and a crystalline oxide containing Al, Mg, and Si is present as secondary phase grains in the dielectric ceramic.
US08673778B2 Tungsten film forming method
A tungsten film forming method for forming a tungsten film on a surface of a substrate while heating the substrate in a depressurized atmosphere in a processing chamber includes forming an initial tungsten film for tungsten nucleation on the surface of the substrate by alternately repeating a supply of WF6 gas which is raw material of tungsten and a supply of H2 gas which is a reducing gas in the processing chamber while performing a purge in the processing chamber between the supplies of the WF6 gas and the H2 gas and adsorbing a gas containing a material for nucleation onto a surface of the initial tungsten film. The film forming method further includes depositing a crystallinity blocking tungsten film for blocking crystallinity of the initial tungsten film by supplying the WF6 gas and the H2 gas into the processing chamber.
US08673776B2 Method for manufacturing semiconductor device having interlayer dielectric layers and a gate contact
A method for manufacturing a semiconductor device comprises: providing a substrate having an active area and a gate structure on the active area and formed with a first interlayer dielectric layer thereon, wherein the first interlayer dielectric layer has a first open to expose a portion of a surface of the active area, and an upper surface of the first interlayer dielectric layer is substantially flush with an upper surface of the gate; filling the first open with a first conductive material to form a first portion of contact; forming a second interlayer dielectric layer over the first interlayer dielectric layer, the second interlayer dielectric layer having a second open to substantially expose an upper part of the first portion of the contact in the first open; and filling the second open with a second conductive material to form a second portion of the contact.
US08673773B2 Method for producing a nanoporous layer
A method for producing a nanoporous layer comprises applying a plating base with adhesion strengthening onto a substrate, depositing a layer made of gold and silver onto the substrate, the composition being in the range of 20% to 40% gold and 80% to 60% silver, and selectively removing the silver in order to produce a nanoporous gold layer.
US08673772B2 Biosensor chip and a method of manufacturing the same
A method of forming a biosensor chip enables a bond pad and detector electrode to be formed of different materials (one is formed of a connection layer such as copper and the other is formed of a diffusion barrier layer such as tantalum or tantalum nitride). A single planarizing operation is used for both the bond pad and the detector electrode. By using the same processing, resist patterning on an already-planarized surface is avoided, and the cleanliness of both the bond pad and detector electrode is ensured. Self-aligned nanoelectrodes and bond pads are obtained.
US08673769B2 Methods and apparatuses for three dimensional integrated circuits
Methods and apparatuses for fabricating three-dimensional integrated circuits having through hole vias are provided. One aspect of the present invention is a method of gapfill for through hole vias for three-dimensional integrated circuits. The method comprises providing a semiconductor wafer having a plurality of holes for through hole vias and depositing a conformal metal layer to partially fill the holes to leave open voids. The method also includes purging the voids and cleaning the surface of the voids and using a dry deposition process to fill or close the voids. Another aspect of the present invention is an electronic device structure for a three-dimensional integrated circuit.
US08673757B2 Structure and method for using high-k material as an etch stop layer in dual stress layer process
A method is provided that includes forming a high-k dielectric etch stop layer over at least a first conductivity type semiconductor device on a first portion of a substrate and at least a second conductivity type semiconductor device on a second portion of the semiconductor device. A first stress-inducing layer is deposited over the first conductivity type semiconductor device and the second conductivity type semiconductor device. The portion of the first stress-inducing layer that is formed over the second conductivity type semiconductor device is then removed with an etch that is selective to the high-k dielectric etch stop layer to provide an exposed surface of second portion of the substrates that includes at least the second conductivity type semiconductor device. A second stress-inducing layer is then formed over the second conductivity type semiconductor device.
US08673756B2 Out-of-plane spacer defined electrode
In one embodiment, a method of forming an out-of-plane electrode includes providing an oxide layer above an upper surface of a device layer, providing a first cap layer portion above an upper surface of the oxide layer, etching a first electrode perimeter defining trench extending through the first cap layer portion and stopping at the oxide layer, depositing a first material portion within the first electrode perimeter defining trench, depositing a second cap layer portion above the first material portion, vapor releasing a portion of the oxide layer, depositing a third cap layer portion above the second cap layer portion, etching a second electrode perimeter defining trench extending through the second cap layer portion and the third cap layer portion, and depositing a second material portion within the second electrode perimeter defining trench, such that a spacer including the first material portion and the second material portion define out-of-plane electrode.
US08673754B2 Method of forming gate dielectric layer and method of fabricating semiconductor device
A method for fabricating a semiconductor device includes ion-implanting germanium into a monocrystalline silicon-containing substrate; forming a gate oxide layer over a surface of the monocrystalline silicon-containing substrate and forming, under the gate oxide layer, a germanium-rich region in which the germanium is concentrated, by performing a plasma oxidation process; and crystallizing the germanium-rich region by performing an annealing process.
US08673741B2 Etching a laser-cut semiconductor before dicing a die attach film (DAF) or other material layer
Semiconductor die break strength and yield are improved with a combination of laser dicing and etching, which are followed by dicing an underlying layer of material, such as die attach film (DAF) or metal. A second laser process or a second etch process may be used for dicing of the underlying layer of material. Performing sidewall etching before cutting the underlying layer of material reduces or prevents debris on the kerf sidewalls during the sidewall etching process. A thin wafer dicing laser system may include either a single laser process head solution or a dual laser process head solution to meet throughput requirements.
US08673733B2 Methods of transferring layers of material in 3D integration processes and related structures and devices
Methods of transferring a layer of semiconductor material from a first donor structure to a second structure include forming a generally planar weakened zone within the first donor structure defined by implanted ions therein. At least one of a concentration of the implanted ions and an elemental composition of the implanted ions may be formed to vary laterally across the generally planar weakened zone. The first donor structure may be bonded to a second structure, and the first donor structure may be fractured along the generally planar weakened zone, leaving the layer of semiconductor material bonded to the second structure. Semiconductor devices may be fabricated by forming active device structures on the transferred layer of semiconductor material. Semiconductor structures are fabricated using the described methods.
US08673732B2 Method for fabricating micro-electro-mechanical systems (MEMS) device
Method is to fabricate a MEMS device with a substrate. The substrate has through holes in the substrate within a diaphragm region and optionally an indent space from the second surface at the diaphragm region. A first dielectric structural layer is then disposed over the substrate from the first surface, wherein the first dielectric structural layer has a plurality of openings corresponding to the through holes, wherein each of the through holes remains exposed by the first dielectric structural layer. A second dielectric structural layer with a chamber is disposed over the first dielectric structural layer, wherein the chamber exposes the openings of the first dielectric structural layer and the through holes of the substrate to connect to the indent space. A MEMS diaphragm is embedded in the second dielectric structural layer above the chamber, wherein an air gap is formed between the substrate and the MEMS diaphragm.
US08673725B2 Multilayer sidewall spacer for seam protection of a patterned structure
A semiconducting device with a multilayer sidewall spacer and method of forming are described. In one embodiment, the method includes providing a substrate containing a patterned structure on a surface of the substrate and depositing a first spacer layer over the patterned structure at a first substrate temperature, where the first spacer layer contains a first material. The method further includes depositing a second spacer layer over the patterned substrate at a second substrate temperature that is different from the first substrate temperature, where the first and second materials contain the same chemical elements, and the depositing steps are performed in any order. The first and second spacer layers are then etched to form the multilayer sidewall spacer on the patterned structure.
US08673721B2 Three-dimensional semiconductor memory device and method for manufacturing the same
A three-dimensional semiconductor memory device includes a stacked structure including a plurality of conductive patterns, an active pillar penetrating the stacked structure, and a data storage pattern between the active pillar and the conductive patterns, wherein the active pillar includes a vertical semiconductor pattern penetrating the stacked structure and protruding semiconductor patterns between the vertical semiconductor pattern and the data storage pattern, the protruding semiconductor patterns having a different crystalline structure from that of the vertical semiconductor pattern.
US08673715B2 Memory device and method of fabricating thereof
Subject matter disclosed herein relates to a process flow to form a gate structure of a memory device.
US08673708B2 Replacement gate ETSOI with sharp junction
A method includes providing a silicon-on-insulator wafer (e.g., an ETSOI wafer); forming a sacrificial gate structure that overlies a sacrificial insulator layer; forming raised source/drains adjacent to the sacrificial gate structure; depositing a layer that covers the raised source/drains and that surrounds the sacrificial gate structure; and removing the sacrificial gate structure leaving an opening that extends to the sacrificial insulator layer. The method further includes widening the opening so as to expose some of the raised source/drains, removing the sacrificial insulator layer and forming a spacer layer on sidewalls of the opening, the spacer layer covering only an upper portion of the exposed raised source/drains, and depositing a layer of gate dielectric material within the opening. A gate conductor is deposited within the opening.
US08673707B2 Method for forming metal gate
A method for forming a metal gate includes providing a substrate, subsequently forming a dummy gate on the substrate, forming spacers on sidewalls of the dummy gate, forming a stop layer on the substrate, the dummy gate and spacers of the dummy gate, and forming a sacrificial dielectric layer on the dummy gate and the stop layer. The method further includes removing a part of the sacrificial dielectric layer and the stop layer until the dummy gate is exposed and, removing a residual sacrificial dielectric layer, depositing an interlayer dielectric layer on the dummy gate and the stop layer, polishing the interlayer dielectric layer until the dummy gate is exposed, removing the dummy gate to form a trench, and forming a metal gate in the trench. The interlayer dielectric layer is flat and substantially flush with the dummy gate, so that no recesses are formed thereon.
US08673701B2 Semiconductor structure and method for manufacturing the same
The present application discloses a semiconductor structure and method for manufacturing the same. The semiconductor structure comprises: an SOI substrate and a MOSFET formed on the SOI substrate, wherein the SOI substrate comprises, in a top-down fashion, an SOI layer, a first buried insulator layer, a buried semiconductor layer, a second buried insulator layer, and a semiconductor substrate, the buried semiconductor layer including a backgate region including a portion of the buried semiconductor layer doped with a dopant of a first polarity; the MOSFET comprises a gate stack and source/drain regions, the gate stack being formed on the SOI layer, and the source/drain regions being formed in the SOI layer at opposite sides of the gate stack; and the backgate region includes a counter-doped region, the counter-doped region is self-aligned with the gate stack and includes a dopant of a second polarity, and the second polarity is opposite to the first polarity. The embodiment of the present disclosure can be used for adjusting a threshold voltage of a MOSFET.
US08673698B2 Generation of multiple diameter nanowire field effect transistors
A method of modifying a wafer having a semiconductor disposed on an insulator is provided and includes forming first and second nanowire channels connected at each end to semiconductor pads at first and second wafer regions, respectively, with second nanowire channel sidewalls being misaligned relative to a crystallographic plane of the semiconductor more than first nanowire channel sidewalls and displacing the semiconductor toward an alignment condition between the sidewalls and the crystallographic plane such that thickness differences between the first and second nanowire channels reflect the greater misalignment of the second nanowire channel sidewalls.
US08673694B2 Thin film transistor array panel and method of manufacturing the same
A thin film transistor array panel includes a passivation layer formed on a plurality of end portions of a plurality of gate lines. A portion of the passivation layer has a porous structure formed between a connection portion of a flexible printed circuit substrate and a thin film transistor substrate such that when the flexible printed circuit substrate and the thin film transistor array panel are connected to each other, the passivation layer having a porous structure and which is formed at the connection portion therebetween connects the flexible printed circuit substrate with the thin film transistor array panel thereby minimizing an exposed area of the metal of the connection portion to improve a corrosion resistance thereof.
US08673693B2 Methods for forming materials using micro-heaters and electronic devices including such materials
Nano-sized materials and/or polysilicon are formed using heat generated from a micro-heater, the micro-heater may include a substrate, a heating element unit formed on the substrate, and a support structure formed between the substrate and the heating element unit. Two or more of the heating element units may be connected in series.
US08673692B2 Charging controlled RRAM device, and methods of making same
Disclosed herein is a novel charging controlled RRAM (Resistance Random Access Memory), and various methods of making such a charging controlled RRAM device. In one example, a device disclosed herein includes a first word line structure formed above a substrate, wherein the first word line structure includes a gate electrode and a nano-crystal containing layer of insulating material, a second word line structure formed above the substrate, wherein the second word line structure comprises a gate electrode and a nano-crystal containing layer of insulating material, a first implant region formed in the substrate proximate the first word line structure, wherein the first implant region defines a first bit line, and a second implant region formed in the substrate proximate the second word line structure, wherein the second implant region defines a second bit line.
US08673690B2 Method for manufacturing a semiconductor device and a semiconductor device
A method for manufacturing a semiconductor device according to one embodiment of the present invention includes a step of covering a plurality of base plates in which respective semiconductor chips are mounted, by means of a sealing resin such that a plurality of base plates are spaced apart from each other, and a step of cutting the sealing resin between a plurality of base plates.
US08673687B1 Etched hybrid die package
An embodiment includes a method that includes encapsulating a die and at least a portion of a lead-frame in a mold to form a package body. At least one primary lead attached to the lead-frame extends from the package body. The method includes etching a feature to within a threshold in an exposed die pad. The exposed die pad comprises a first surface that is prepared for etching and a second surface opposite to the first surface and attached to the die. The method includes positioning the die within a footprint of the exposed die pad, connecting the die to at least one primary lead, and connecting the feature to the die.
US08673686B2 Chip package structure and manufacturing method thereof
An embodiment of the present invention provides a manufacturing method of a chip package structure including: providing a first substrate having a plurality of predetermined scribe lines defining a plurality of device regions; bonding a second substrate to the first substrate, wherein a spacing layer is disposed therebetween and has a plurality of chip support rings located in the device regions respectively, a cutting support structure located on peripheries of the chip support rings, a plurality of stop rings surrounding the chip support rings respectively, wherein a gap pattern separating the stop rings from the cutting support structure and the chip support rings; and cutting the first substrate and the second substrate to form a plurality of chip packages. Another embodiment of the present invention provides a chip package structure.
US08673681B2 Electrical device fabrication
The invention provides a method of making an electrical device, particularly a semiconductor device, having a substrate and etched electrodes formed on the substrate. The method employs flexography to print a resist pattern (7) onto a substrate (5) carrying a metal layer (8). Metal not protected by the resist can be etched away and then the resist (7) removed to leave exposed electrodes. Further materials (10, 11) can be disposed onto the exposed metal, such as organic semiconductors, to form transistors or diodes.
US08673678B2 Process of making a thin-film photovoltaic device and thin-film photovoltaic device
A thin-film photovoltaic device and a process of making such a device, the device comprising a first layer of a chalkopyrite semiconductor of a first doping type; a second layer of intrinsic zinc oxide deposited by chemical vapor deposition; a third layer of zinc oxide semiconductor of a second doping type opposite to the first doping type and deposited by a method other than chemical vapor deposition; and wherein the second layer is arranged between the first and third layers.
US08673677B2 Method for producing group III nitride semiconductor light emitting element
A reflective film including Ag of an Ag alloy is patterned in a uniform thickness without decreasing reflectivity. The reflective film is formed on the entire surface of a first insulating film by sputtering, vacuum deposition or the like, and a barrier metal film having a given pattern is formed on the reflective film by a lift-off method. The reflective film is wet etched using a silver etching liquid. The barrier metal film is not wet etched by the silver etching liquid, and therefore functions as a mask, and the reflective film in a region on which the barrier metal film has been formed remains not etched. As a result, the reflective film having a desired patter can uniformly be formed on the first insulating film.
US08673673B2 Trench process and structure for backside contact solar cells with polysilicon doped regions
A solar cell includes polysilicon P-type and N-type doped regions on a backside of a substrate, such as a silicon wafer. An interrupted trench structure separates the P-type doped region from the N-type doped region in some locations but allows the P-type doped region and the N-type doped region to touch in other locations. Each of the P-type and N-type doped regions may be formed over a thin dielectric layer. Among other advantages, the resulting solar cell structure allows for increased efficiency while having a relatively low reverse breakdown voltage.
US08673667B2 Method for manufacturing light emitting diode chip
A manufacturing method of an LED chip includes the following steps: providing a substrate; forming a light emitting layer comprising an n-type semiconductor layer and a p-type semiconductor layer on the substrate; forming a pair of electrodes electrically connected the n-type semiconductor layer and the p-type semiconductor layer, respectively; connecting a bonding wire to one of the electrodes by adding melted metal to a portion of a top surface of the electrode, a ratio between an area of the portion of the top surface of the electrode and the top surface of the electrode being no less 6:10; and solidifying the melted metal to form a bonding pad to connect the bonding wire and the electrode together.
US08673666B2 Light-emitting devices with textured active layer
A device includes a textured substrate having a trench extending from a top surface of the textured substrate into the textured substrate, wherein the trench comprises a sidewall and a bottom. A light-emitting device (LED) includes an active layer over the textured substrate. The active layer has a first portion parallel to the sidewall of the trench and a second portion parallel to the bottom of the trench.
US08673665B2 Pixel performance improvement by use of a field shield
A pixel cell (100) and method for making the same for an active matrix display includes a pixel pad (110) and a thin film field effect transistor (106) which selectably couples a signal to activate/deactivate the pixel pad. A field shield (112) is formed on an insulating layer (102) and connected to the pixel pad through the insulating layer such that the field shield extends over at least a portion of the pixel pad. The field shield may extend over the thin film transistor and form a second gate (215) used to enhance the performance of the thin film transistor and the pixel cell.
US08673658B2 Fabricating method of semiconductor device
A fabricating method and a testing method of a semiconductor device and a mechanical integrity testing apparatus are provided. An object includes a wafer, an insulating layer, and a plurality of conductive posts is provided. A surface of the wafer has a plurality of first blind holes outside chip regions and a plurality of second blind holes inside the chip regions. The insulating layer is between the conductive posts and the walls of the first blind holes and between the conductive posts and the walls of the second blind holes. A mechanical integrity test is performed to test a binding strength between the insulating layer, the conductive posts, and the walls of the first blind holes. The conductive posts in the chip regions are electrically connected to an element after the conductive posts in the first blind holes are qualified in the mechanical integrity test.
US08673657B2 Semiconductor device including a circuit area and a monitor area having a plurality of monitor layers and method for manufacturing the same
In a circuit area wherein a semiconductor integrated circuit is to be formed, an isolation insulating film is formed on a surface of a semiconductor substrate, and, at the same time, five isolation insulating films extending in one specific direction are formed within a monitor area at a fixed spacing. Then, a gate insulation film and a gate electrode are formed within the circuit area on the semiconductor substrate, and, at the same time, five gate insulation films and five gate electrodes extending in the same direction as the isolation insulating films are formed within the monitor area at the same spacing as that of the isolation insulating films.
US08673655B1 Semiconductor package repair process
An electronic package implemented in an electronic device may include a damaged connection that restricts electrical communication between components in the electronic package. For example, the damaged connection may restrict communication between a silicon unit, such as a processor die for example, and a printed circuit board. The damaged connection may be repaired without damaging other components in the electronic package by using a repair apparatus that includes a heating element and a cooling element. The heating element may be activated to transfer heat to the electronic package for reforming the damaged connection between components to enable effective electrical communication. The cooling element may be activated for cooling components in the electronic package to prevent damage due to the transfer of the heat from the heating element. The heating element and/or the cooling element may be activated in a predetermined pattern to facilitate the repair of the damaged connection.
US08673654B2 Underlayer for high performance magnetic tunneling junction MRAM
An MRAM structure is disclosed in which the bottom electrode has an amorphous TaN capping layer to consistently provide smooth and dense growth for AFM, pinned, tunnel barrier, and free layers in an overlying MTJ. Unlike a conventional Ta capping layer, TaN is oxidation resistant and has high resistivity to avoid shunting of a sense current caused by redeposition of the capping layer on the sidewalls of the tunnel barrier layer. Alternatively, the α-TaN layer is the seed layer in the MTJ. Furthermore, the seed layer may be a composite layer comprised of a NiCr, NiFe, or NiFeCr layer on the α-TaN layer. An α-TaN capping layer or seed layer can also be used in a TMR read head. An MTJ formed on an α-TaN capping layer has a high MR ratio, high Vb, and a RA similar to results obtained from MTJs based on an optimized Ta capping layer.
US08673653B2 Signal amplification technique for mass analysis
Provided is a novel method for amplifying mass spectrometric signals. A novel method for detecting signals of a target molecule includes: allowing a sample, which comprises a target molecule, to contact a gold particle having a surface modified to selectively bind the target molecule, allowing a low molecular weight molecule engrafted to the gold particle generate mass spectrometric signals after the interaction, e.g., binding, between the gold particle and the target molecule, and amplifying the mass spectrometric signals to generate much mass spectrometric signals of the low molecular weight molecule even when trace amounts of the target molecule are present. An assay system using the method and the gold particle prepared in the method are provided. The method amplifies signals of the target molecule without pretreatment of a sample, making it possible to measure the target molecule simply and precisely.
US08673651B2 Liquids test probe
A package for holding and disguising a chromatographic test of food and drink is formed in the shape of a drinking straw or stirrer. The package encloses test patches which are sensitive to particular drugs and produce a color change upon contact with the drug. The package has a view port or slit to observe the condition of the test strip upon contact with food and drink.
US08673650B2 Optical molecular detection
Optical detection of molecules using a biochip having at least one reagent immobilizing area designed to receive one or more reagents and at least one calibration structure with a predetermined height to provide a height reference for optical measurement is disclosed. When the calibration structure is illuminated by a probe beam of light, a first reflected beam of light is reflected off the calibration structure, and a second reflected beam of light is reflected off the reagent immobilizing area. The first reflected beam and the second reflected beam are compared to determine a height at the reagent immobilizing area.
US08673645B2 Apparatus and methods for conducting assays and high throughput screening
The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of branch flow channels; a plurality of control channels; and a plurality of valves. Preferably, each of the valves comprises one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel.
US08673638B2 Cell culture support and cell culture method
The present invention relates to a cell culture support for culturing mesenchymal stem cells, which includes en upper surface including a plurality of wells, in which the upper surface has a root mean square roughness Rq of 100 to 280 nm and a linear density of 1.6 to 10 per 1 μm length.
US08673637B2 Human multipotent germ line stem cells expressing a germ line marker and a pluripotency marker produced by co-culture of testicular tissue
A method of in vitro maturation of adult human germ line cells in an artificial biological environment, which entails: a) isolating human spermatogonial stem cells (SSCs), and optionally purifying the same; and b) co-culturing the isolated and optionally purified SSCs with a suitably adjusted Sertoli cell environment to obtain haploid germ cells.
US08673632B2 Modulation of apolipoprotein (a) expression
Compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein(a). Methods of using these compounds for modulation of apolipoprotein(a) expression and for diagnosis and treatment of disease associated with expression of apolipoprotein(a) are provided.
US08673631B2 Chimeric regulatory sequences comprising introns for plant gene expression
The present invention relates to a method of using a dicot intron or elements thereof to enhance transgene expression in plants. The present invention also provides constructs, transgenic plants and seeds containing the polynucleotide useful for expressing transgene in plants.
US08673630B2 βGI-IgG intron for enhanced anti-IGF1R expression
The present invention provides polynucleotides for enhanced expression of a target gene such as an immunoglobulin. Methods of expressing a target gene using the polynucleotides of the invention are also covered.
US08673628B2 Methods and apparatus for improving in vitro measurements using boyden chambers
Apparatus and methods to improve the Boyden chamber used in cellular biological measurements, allowing quantitative optical microscopy of biological cells in situ without using fluorescent probes or optical staining. In the preferred embodiment, a thin porous membrane separating top and bottom reservoirs includes an array of precisely positioned micropores pores manufactured using a laser-based photo-machining (ablation) process. The membrane may be composed of polyethylene terephthalate (PET), polycarbonate, polyimide, polyether ether ketone (PEEK) or other appropriate material. The pores formed in the membrane may have diameters in the range of 1 to 15 microns and spaced apart at a distance ranging from 10 to 200 microns. A plurality of upper and lower reservoirs may be provided to form a multi-well plate. The invention finds application in a wide range of potential biological applications where Boyden chamber geometries are currently used including co-culture studies, tissue remodeling studies, cell polarity determinations, endocrine signaling, cell transport, cell permeability, cell invasion and chemotaxis assays.
US08673625B2 Valved, microwell cell-culture device and method
A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states to control the flow of fluid through a microchannel. The microvalve is formed of three flexible membranes, one of which is responsive to pneumatic pressure applied to the valve and the other two of which deform to produce a more sealable channel cross-section. The cell culture device provides valving to allow controlled loading of cells into the individual well of the device, and exchange of cell-culture components in the wells.
US08673612B2 Synthetic viruses and uses thereof
The present invention relates to compositions and methods for producing an immune response or reaction, as well as to vaccines, kits, processes, cells and uses thereof. This invention more particularly relates to compositions and methods of using a synthetic viral particle to produce, modify or regulate an immune response in a subject. In a more preferred embodiment, the invention is based, generally, on compositions using synthetic viral particles as an adjuvant and/or vehicle to raise an immune response against selected antigen(s) or epitopes, in particular a cellular and/or a humoral immune response.
US08673608B2 Branched α-glucan, α-glucosyltransferase which forms the glucan, their preparation and uses
The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.
US08673607B2 Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N,N-dimethyl-3-keto-3-(2-thienyl)-1-ketopropanamine to (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
US08673606B2 Microorganism comprising particles and uses of same
A particle is disclosed. The particle comprising: (i) at least one inner core which comprises a solid matrix of nutrients for microorganism growth; (ii) an inner membrane being fabricated from a water-soluble polymer, the inner membrane surrounding the inner core and a population of dried microorganisms; and (iii) an outer porous membrane surrounding the inner membrane, the outer porous membrane being insoluble in water. Methods of generating same, propagating microorganisms within and uses of same are also disclosed.
US08673603B2 Fermentation process for controlling butanediol production
Methods for improving the efficiency of 2,3-butanediol fermentations are disclosed. More specifically methods of increasing the butanediol productivity from the anaerobic fermentation of a substrate comprising carbon monoxide or carbon monoxide and hydrogen by one or more caboxydotrophic acetogenic bacteria are disclosed. The method includes supplying a hydrogen depleted substrate to increase butanediol productivity. The method includes producing butanediol at a volumetric productivity rate of at least 15 g/L/day.
US08673600B2 Method and apparatus for producing lactic acid
Disclosed is an apparatus and a method for producing lactic acid, wherein only lactic acid is selectively absorbed and separated from fermentation liquor using a lactic acid absorption resin and wherein a neutralizing agent is not used. The present invention does not include a neutralizing process and a process of converting lactate to lactic acid. The method comprises: adding and mixing a culture medium, microorganism and sugar in a fermenter; passing a fermentation liquor through a microorganism filtration unit to remove microorganisms; and selectively absorbing and separating lactic acid from filtered liquid using a lactic acid absorption resin. The apparatus includes a fermenter for lactic acid fermentation; a filtration unit for removing a microorganisms from the fermentation liquor; and a lactic acid absorption resin for selectively absorbing lactic acid from the filtered liquid.
US08673597B2 Method for producing L-amino acid
A bacterium which belongs to the family Enterobacteriaceae, and has an ability to produce L-lysine, L-threonine, L-asparagine, L-aspartic acid, L-methionine, L-alanine, L-isoleucine, and/or L-homoserine. The bacterium has been modified so that expression of the gltP and/or gltS genes is/are increased when cultured in a medium, resulting in the accumulation of the L-amino acid(s) in the medium or bacterial cells.
US08673596B2 Method for production of fermentable sugars from biomass
A process for production of fermentable sugars from biomass using multi-enzyme multi-step system is provided herein. The process disclosed in the present invention provides high yielded sugars in less time period. The multi-enzyme system disclosed in the present invention converts celluloses, hemicelluloses and/or mixture thereof to fermentable sugar with higher efficiency and better economics than the process known in the prior art. Cellulose and hemicelluloses fractions derived from natural sources such as any lignocellulosic biomass are saccharified in a shortened time with higher conversion rates of intermediates with modified enzymatic compositions/groups of the Multi-enzyme system to enhance the rate thus providing an economical cellulose and hemicellulose saccharification process.
US08673594B2 Methods for stimulating nervous system regeneration and repair by regulating arginase I and polyamine synthesis
This invention relates to the novel identification of arginase as an enzymatic activity which can reverse inhibition of neuronal regeneration in the central and peripheral nervous system. Assays to monitor the effects of various agents on arginase expression and thus on neuronal regeneration and repair and to identify agents which will block or promote the inhibitory effects on neuronal outgrowth are provided. This invention also relates to compositions and methods using agents that can reverse the inhibitory effects of myelin on neural regeneration by affecting arginase activity or putrescine and derivative polyamine levels in a neuron. Methods for regulating and for promoting (or repressing) neuronal growth or regeneration in the nervous system, methods for treating injuries or damage to nervous tissue or neurons, and methods for treating neural degeneration associated with conditions, disorders or diseases, comprising the step of administering at least one of the compositions according to this invention, are provided.
US08673584B2 Inhibitor scaffold for the inhibition of the enzyme phosphoenolpyruvate carboxykinase
A PEPCK inhibitor can include identifying a molecule that has a size capable of fitting into and interacting with the PEPCK binding site and at least one of the following: (a) a first terminal substituent having co-planar atoms acting as metal ligands to the active site metal ion PEPCK; (b) at least one of an atom or substituent at positions 2 or 3 from the first terminal substituent includes a neutral carbon center or include an oxygen, sulfur, selenium, or other atom with similar physiochemical properties; (c) at least one of an atom or substituent at positions 2 or 3 from the first terminal substituent is devoid of an electropositive atom or substituents; or (d) a second terminal substituent opposite of the first terminal substituent, said second terminal substituent having an atom that is a hydrogen boding acceptor and/or is negatively charged.
US08673583B2 Monoclonal antibodies and detection methods for enzymes that confer resistance to 2,4-dichlorophenoxyacetic acid
Described herein are monoclonal antibodies and methods useful for determining and quantitating the presence of AAD-1 (aryloxyalkanoate dioxygenase) enzyme. These monoclonal antibodies are surprisingly well suited for detecting AAD-1 transgenic event gene products in a variety of plants and plant tissues. The invention further provides quantitative and qualitative immunoassays using the immunoglobulins of the invention.
US08673582B2 Methods for determining the risk of prenatal complications
The disclosure relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual has for developing pre-eclampsia based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers. The disclosure also relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual is carrying a fetus having a chromosomal abnormality based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers.
US08673581B2 sCD40L and placental growth factor (PLGF) as biochemical marker combinations in cardiovascular diseases
The invention relates to novel markers of vascular inflammation and combinations thereof as diagnostic and prognostic tools in patients with cardiovascular diseases. The markers also act as tools that facilitate the selection of active ingredients for the treatment of such diseases, and finally act as starting points for the treatment of cardiovascular diseases. Furthermore, the invention relates to the creation of an individual risk profile of negative events that are associated with the progression of arteriosclerosis.
US08673576B2 Multi-wavelength analyses of sol-particle specific binding assays
The present invention discloses methods for detecting the presence of a complex between a first reagent and a second reagent in solution. In particular, the invention provides methods for qualitative or quantitative detection of an analyte or its specific binding partner in complex biological samples. The invention further discloses algorithms using summary rate changes at selected wavelengths in the absorbance spectra of colloidal metal-labeled analytes or specific binding partners to identify intermolecular interactions between the analyte and its binding partner.
US08673574B2 Diagnosis and monitoring of renal failure using peptide biomarkers
Methods for the determination of renal failure, especially chronic renal failure and acute kidney injury, by measurement of peptide or protein biomarkers are described. The methods are useful to determine stages of renal failure, especially the early stages such as stage 1, 2, and 3 of chronic renal failure and stages R and I of acute kidney injury. Furthermore there are described peptides and test kits used in the invention. The described methods are intended to replace or complement the measurement of creatinine and/or cystatin C and/or NGAL for diagnosis of renal failure.
US08673564B2 In situ methods for gene mapping and haplotyping
The present invention is directed to in situ methods for providing a definitive haplotype of a subject. The haplotype information generated by the methods described herein is more accurate than that provided by prior art methods that only give an inferred haplotype. Accordingly, in one aspect the present invention provides an in situ method for obtaining genetic information for a polyploid subject, the method including the steps of obtaining a biological sample from the subject, the sample containing: (i) at least one paternally-derived DNA molecule, and/or (ii) at least one maternally-derived DNA molecule, analyzing any one or more of the paternally- or maternally-derived DNA molecules for nucleotide sequence information, wherein the step of analyzing determines whether any two DNA markers are present in cis on one chromosome, or in trans across two sister chromosomes. Use of in situ methods such as FISH allows for the provision of phase-specific information on DNA markers without recourse to methods for physically separating sister chromosomes. Applicants propose that method eliminates the problem of incorrect or misleading inferences concerning the phase of two or more loci within a haplotype, and allows for revelation of two or more participatory genes within a haplotype, uncomplicated by differences in modes of inheritance.
US08673559B2 Methods for accurate sequence data and modified base position determination
Disclosed herein are methods of determining the sequence and/or positions of modified bases in a nucleic acid sample present in a circular molecule with a nucleic acid insert of known sequence comprising obtaining sequence data of at least two insert-sample units. In some embodiments, the methods comprise obtaining sequence data using circular pair-locked molecules. In some embodiments, the methods comprise calculating scores of sequences of the nucleic acid inserts by comparing the sequences to the known sequence of the nucleic acid insert, and accepting or rejecting repeats of the sequence of the nucleic acid sample according to the scores of one or both of the sequences of the inserts immediately upstream or downstream of the repeats of the sequence of the nucleic acid sample.
US08673555B2 Detecting neoplasm
This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.
US08673552B2 Druggable regions in the dengue virus envelope glycoprotein and methods of using the same
The present invention relates to novel druggable regions discovered in dengue virus envelope glycoprotein, or dengue virus E protein, which is a class II viral E protein. The present invention further relates to methods of using the druggable regions to screen potential candidate therapeutics for diseases caused by viruses having class II E proteins, e.g. viral fusion inhibitors.
US08673551B2 Methods, plasmid vectors and primers for assessing HIV viral fitness
The present invention relates to methods and means for the evaluation of HIV replicative capacity in a given environment. In particular, the invention provides a growth competition assay that can determine relative viral fitness using a recombinant tagged HIV-1 virus system. The methods rely on plasmid vectors, amplicons, primers and probes, and the generation of replication-competent viruses therefrom. Said methods and materials may find use in multiple fields including diagnostics, drug screening, pharmacogenetics and drug development.
US08673548B2 Genes and polypeptides relating to breast cancers
The present application provides novel human genes A7322, whose expression is markedly elevated in breast cancer. The present application also provides human genes F3374 whose expression is markedly elevated in breast cancer. These genes and polypeptides encoded thereby can be used, for example, in the diagnosis of breast cancer, and as target molecules for developing drugs against breast cancer. The invention features methods of screening for modulators of the kinase activity of PBK/TOPK. The invention further provides methods of screening for agents to prevent or treat cancer, such as breast cancer.
US08673543B2 Method for manufacturing semiconductor device
A reverse pattern is formed once by combining a negative exposure mask having a wiring pattern with a positive resist, and then a positive wiring pattern is formed by use of the reverse pattern. That is, a positive resist applied on a semiconductor substrate is exposed by use of the exposure mask having an opening part in a region corresponding to the wiring pattern, and then the exposed part is removed by development to form a resist pattern, thereby forming the wiring pattern in the region corresponding to the opening part of the resist pattern. Consequently, it is hardly affected by flare during EUV exposure, thereby fabricating a fine wiring pattern with higher exposure latitude.
US08673539B2 Photosensitive adhesive composition, and obtained using the same, adhesive film, adhesive sheet, semiconductor wafer with adhesive layer, semiconductor device and electronic part
A photosensitive adhesive composition comprising: (A) a polyimide having a carboxyl group as a side chain, whereof the acid value is 80 to 180 mg/KOH; (B) a photo-polymerizable compound; and (C) a photopolymerization initiator.
US08673533B2 Aqueous dispersions for use as toners
A compound that includes an aqueous dispersion, wherein the dispersion includes a thermoplastic resin and at least one stabilizing agent, and at least one selected from the group consisting of a colorant and a magnetic pigment, wherein the dispersion has an average volume diameter particle size from about 0.05 to about 10 microns is described.
US08673532B2 Method of producing dry toner particles having high circularity
A method for producing dry toner particles that have similar particle size and shape characteristics as chemically produced toners. The method includes melt-mixing a toner resin with a colorant and, optionally, a wax, to form a toner; grinding the toner to form toner particles; classifying the toner particles into particles averaging 4 to 10 microns in size; blending the classified toner particles with additives in a high-speed blender; and then processing the mixture with optional additional surface additives in a conical mixer. The method produces toner particles that have high circularity and sharper particle size distribution. The surface processing of the toner particles does not affect the internal constituents of the toner particles.
US08673530B2 Alkyl silane surface treated silica for toner
The present disclosure describes toner compositions comprising an alkyl surface-treated silica, which toners exhibit improved tribo-charging, second transfer efficiency and IQ without impacting color.
US08673528B2 Toner, developer, toner accommodating container, process cartridge and image forming method
A toner including at least one polyester resin serving as a binder resin, a colorant, a releasing agent, and a fixing aid, wherein the fixing aid includes a fatty acid amide-based compound, and the fatty acid amide-based compound is at least one of a fatty acid amide compound having a mono- or higher valent amide bond and a fatty acid amide-based compound having a mono- or higher valent amino group or a hydroxyl group.
US08673523B2 Image holding member for image forming apparatus, process cartridge, and image forming apparatus
An image holding member for an image forming apparatus includes: a substrate; and a photosensitive layer on the substrate, the photosensitive layer containing a compound including a partial structure represented by the following Formula (II-2) wherein in Formula (II-2), Ar represents a substituted or unsubstituted phenyl group, a substituted or unsubstituted monovalent polynuclear aromatic hydrocarbon group having from 2 to 10 aromatic rings, a substituted or unsubstituted monovalent condensed aromatic hydrocarbon group having from 2 to 10 aromatic rings, or a substituted or unsubstituted monovalent aromatic heterocyclic group; q represents 0 or 1; and n's each independently represent an integer of from 0 to 7.
US08673518B2 Fuel cell power generation system with partition wall for main body package
There is provided a fuel cell power generation system in which power loss in a power line electrically connecting a stack and a power conversion circuit, thereby attaining high power generation efficiency. A reformer and the stack are disposed in a main body package. Stack output terminals 31 are provided in both ends in a stacking direction of the stack. A power conversion circuit is disposed in the main body package and arranged in the proximity to the stack. Power conversion circuit input terminals are provided on the power conversion circuit and arrayed in a direction parallel to the stacking direction of the stack. Stack output lines electrically connect the stack output terminals and the power conversion circuit input terminals.
US08673517B2 Polymer electrolyte membrane composed of a fluorinated proton conductive polymer and a fluorinated reinforcing material
To provide a polymer electrolyte membrane for polymer electrolyte fuel cells having high mechanical strength and excellent dimensional stability when it contains water even when it is made thin and the concentration of ionic groups is increased so as to reduce the electrical resistance, and a membrane/electrode assembly providing high output and having excellent durability.
US08673514B2 Fuel cell system and boost converter for fuel cell
Provided is a fuel cell system including a fuel cell which is a DC power source and boosting unit which boosts the output voltage of the fuel cell for supply to a load. The boosting unit has: a main boosting unit which has a switch and a coil and boosts the output voltage of the fuel cell by a back electromotive force of the coil generated by a switching operation of the switch with respect to the coil; and a sub boosting unit having a snubber capacitor which adjusts a potential difference between the both electrodes of the switch by an accumulation amount and reduces the switching loss of the switch by adjusting the accumulation amount of the snubber capacitor upon a switching operation. The electricity of the snubber capacitor discharged when reducing the accumulation amount of the snubber capacitor is made to flow into processing unit other than the fuel cell by the sub boosting unit.
US08673513B2 Determining duration of fuel cell shutdown hydrogen stabilization by counting coulombs
A process for shutting down a fuel cell power plant (5) shuts off (40) process air, recycles (44-46) air exhaust 42 to air inlets 34, and connects an auxiliary load to the stack (6). Coulombs are counted by integrating (17) current (73) or voltage (75) to the load to determine when all oxygen in the air side (10, 27, 30, 34, 42, 44-47) of the power plant is consumed and a desired concentration of hydrogen is transferred to the air side of the power plant. The speed of the shutdown processes may be increased by increasing fuel pressure (15) or adding a battery (78) in series with the auxiliary load.
US08673512B2 Reforming system, fuel cell system, and its operation method
When terminating power generation by a fuel cell 3 in a fuel cell system 1, an amount of a raw fuel material introduced to a reforming catalyst 2a of a reformer 2 is reduced. Here, before the temperature of the reforming catalyst 2a is lowered to the un-reformed gas generation temperature, an amount of water supplied to the reforming catalyst 2a is controlled to increase the temperature of the reforming catalyst 2a. Thus, upon termination of power generation in the fuel cell 3, no un-reformed gas is generated and the reformed gas is supplied to the fuel cell 3.
US08673511B2 Apparatus including sodium chlorate electrolysis cell connected by water cooled catalytic reactor to phosphoric acid fuel cell
A sodium chloride electrolysis cell (9) receives a portion of its electrical power (47, 48: 50, 51) from a phosphoric acid fuel cell (44) which receives fuel at its anode inlet (43) from a water cooled catalytic reactor (26) that converts oxygen in the byproduct output (19) of the sodium chlorate electrolysis cell to hydrogen and water. A utility grid (53) may provide through a converter (55) power to support the electrochemical process in the sodium chlorate electrolysis cell. Temperature of the water cooled catalytic reactor is determined by the vaporization of pressurized hot water, the pressure of which may be adjusted by a controller (36) and a valve (38) in response to temperature (40).
US08673504B2 Non-aqueous electrolyte secondary battery and non-aqueous electrolyte
The objective of the present invention is to prevent deterioration and expanding of anode active material and to improve charge-discharge cycle characteristics in a non-aqueous electrolyte secondary battery comprising an anode of which current collector has thereon a thin layer of an anode active material containing a metal. To solve this problem, in a non-aqueous electrolyte secondary battery wherein a thin layer of anode active material containing a metal which absorbs and discharges lithium is formed on a current collector and the thin layer of the anode active material is divided into columns by a gap formed along the thickness thereof, a compound represented by the following formula is contained in the non-aqueous electrolyte. A-N═C═O In the above formula, A represents an element or a group other than hydrogen.
US08673502B2 Method for producing coated carbon particles and use of the latter in anode materials for lithium-ion batteries
The invention relates to a process for producing coated carbon particles, which comprises coating electrically conductive carbon particles with elemental doped or undoped silicon by chemical vapor deposition from at least one gaseous silane in an oxygen-free gas atmosphere in a reaction space, with the electrically conductive carbon particles being in continual motion during the vapor deposition, and also correspondingly coated carbon particles and their use in anode materials for lithium ion batteries.
US08673496B2 Electrode composition, electrode for lithium secondary battery, method of manufacturing the electrode and lithium secondary battery including the electrode
An electrode composition containing a first conducting agent and a second conducting agent, an electrode for lithium secondary batteries, a method of manufacturing the electrode, and a lithium secondary battery including the electrode. The second conducting agent is an agglomerate formed of a conducting material and a fluorine-based polymer.
US08673491B2 Li-ion battery with selective moderating material
An electrochemical cell in one embodiment includes a negative electrode including a form of lithium, a positive electrode spaced apart from the negative electrode, a separator positioned between the negative electrode and the positive electrode, and a moderator layer positioned between the negative electrode and the separator.
US08673487B2 Rechargeable battery pack
The invention relates to a rechargeable battery pack. Particularly, but not exclusively, the invention relates to a rechargeable battery pack for a battery powered appliance such as a hand held vacuum cleaner. The rechargeable battery pack includes at least one power interface for transferring power from the battery pack to an appliance during use and a single charger input terminal to which an output terminal of a battery charger is connectable during use for charging the battery pack, wherein the single charger input terminal is connectable to the output terminal of a battery charger when the battery pack is connected to an appliance and when the battery pack is not connected to an appliance.
US08673486B2 Battery pack including cover case covering, holder case and protection circuit module
A battery pack having a holder case capable of preventing short-circuit between a cap plate and an electric terminal, instead of a washer, thereby increasing a coupling force between the holder case and a bare cell while minimizing the volume of the battery pack. The battery pack includes a bare cell including an electrode assembly, a can accommodating the electrode assembly, and a cap assembly for finishing an upper opening of the can, a holder case including a bottom portion covering one side surface of the bare cell, first and second support portions formed at first and second sides of the bottom portion, and an insulating portion fixed while covering a portion of a cap plate forming the cap assembly, a protection circuit module coupled to an upper portion of the holder case, and a cover case fixed to one side surface of the bare cell while covering the holder case and the protection circuit module.
US08673483B2 Sealed battery
A sealed battery with an electrode assembly and electrolyte enclosed in a battery case is provided, where a connection member can be attached to the battery case without requiring large space while avoiding increasing the length of the lead wire. The sealed battery includes: a battery case enclosing an electrode assembly and electrolyte, for serving as a terminal of one polarity of the electrode assembly; an external terminal provided on the battery case in such a way that it is electrically insulated from the battery case, for serving as a terminal of another polarity of the electrode assembly; and a sealant member for sealing a fill port for the electrolyte provided side by side with the external terminal on the battery case. A connection member to which a lead wire is to be connected is provided on the battery case to cover at least part of the sealant member.
US08673479B2 Secondary battery and a secondary battery module
A secondary battery and a secondary battery module, the secondary battery including an electrode assembly, the electrode assembly including a positive electrode, a negative electrode, and a separator therebetween; a case for accommodating the electrode assembly; a cap plate for sealing the case; and at least one terminal unit, the at least one terminal unit including a multi-metal electrode rivet electrically connected to one of the electrodes of the electrode assembly, the multi-metal electrode rivet including a first part and a second part, and, a rivet terminal, the rivet terminal being electrically connected to the multi-metal electrode rivet; wherein the rivet terminal and the second part are each formed of a second metallic material, the first part is formed of a first metallic material, and the first metallic material is different from the second metallic material.
US08673477B2 High energy density aqueous lithium/air-battery cells
Li/air battery cells are configurable to achieve very high energy density. The cells include a protected a lithium metal or alloy anode and an aqueous catholyte in a cathode compartment. In addition to the aqueous catholyte, components of the cathode compartment include an air cathode (e.g., oxygen electrode) and a variety of other possible elements.
US08673476B2 Electrode assembly having stable lead-tap joint and electrochemical cell containing them
Disclosed herein is a stacking or stacking/folding type electrode assembly of a cathode/separator/anode structure, wherein the electrode assembly is constructed in a structure in which tabs (electrode tabs), having no active material applied thereto, protrude from electrode plates constituting the electrode assembly, electrode leads are located at one-side ends of the stacked electrode tabs such that the electrode leads are electrically connected to the electrode tabs, and the electrode leads, joined to the electrode tabs, have rounded ends. An electrochemical cell including the electrode assembly is also disclosed.
US08673475B2 Middle or large-sized battery pack case providing improved distribution uniformity in coolant flux
A middle- or large-sized battery pack case is provided in which a battery module having a plurality of stacked battery cells is mounted, wherein the battery pack case is provided with a coolant inlet port and a coolant outlet port, which are disposed such that a coolant for cooling the battery cells can flow from one side to the other side of the battery module in the direction perpendicular to the stacking direction of the battery cells. The battery pack case includes beads formed in a concavo-convex shape for improving the structural stability of the battery pack case against an external force, the beads being constructed in a structure in which the beads do not disturb the flow of the coolant from the coolant inlet port along the advancing direction of a fluid in a flow space defined between the coolant inlet port and the battery module.
US08673473B2 Integrated cooling fin and frame
An integrated cooling fin and frame is described. The integrated cooling fin and frame includes a cooling fin having a cooling channel adjacent to at least one edge, the cooling channel having an inlet and an outlet; and a frame around the cooling fin and covering the edges of the cooling fin, the frame having an opening for the inlet and outlet of the cooling channel. A battery pack containing the integrated cooling fin and frame and a method of making the integrated cooling fin and frame are also described.
US08673471B2 Portable electronic device
Provided is a highly safe portable electronic device having a secondary battery as a power source, and including a housing, an electronic device body housed in the housing, and a battery housing portion housed in the housing, in which a surface is inhibited from being locally heated to high temperature. In the portable electronic device, the battery housing portion is a molding with a battery fitting portion for fitting the secondary battery therein, and the battery fitting portion has provided on its surface a heat-insulating layer having a thickness of from 500 to 3000 μm and a thermal conductivity of 0.2 W/m·K or lower.
US08673469B2 Apparatus for protection of secondary battery
The present invention is an apparatus for protecting a secondary battery, in which, when the secondary battery such as a lithium-ion secondary battery is exposed to high temperature exceeding a working range due to a change in external environment, external impacts, and so on, or heated due to spontaneous generation of heat caused by internal defects, the secondary battery is discharged. The apparatus includes a thyristor or transistor having an anode and a cathode connected both terminals of the secondary battery respectively, and shorting both terminals of the secondary battery when gate current is supplied, and a temperature sensor detecting temperature of the secondary battery and supplying the gate current to the thyristor or transistor when the detected temperature is higher than predetermined temperature.
US08673468B2 Rechargeable battery
A rechargeable battery including an electrode assembly; a case accommodating the electrode assembly; a cap plate sealing the case, the cap plate including a vent hole for discharge of gas; and a safety vent at the vent hole, wherein the safety vent includes main groove at a center thereof; and sub groove around the main groove.
US08673464B2 Low-coupling oxide media (LCOM)
A low-coupling perpendicular magnetic recording media comprising a magnetic storage layer and at least one low saturation magnetization layer. The magnetic storage layer has a saturation magnetization between about 400-900 emu/cm3 and the at least one low saturation magnetization layer has a saturation magnetization below that of the magnetic storage layer.
US08673461B2 Reinforced glass-ceramic article and enamel suitable for the coating thereof
A process for reinforcing a glass-ceramic article, into which a maximum tension is introduced beneath the surface of the glass-ceramic, advantageously in proximity to said surface. The invention also relates to an enamel that can be used for this reinforcement, this enamel being formed from a glass frit having the following composition, the proportions being expressed as weight percentages: SiO250-66%  MgO3-8% Na2O7-15%  K2O0-3% Li2O0-12%  CaO0-10%  BaO0-15%  Al2O30-3% ZrO20-3% ZnO0-5% B2O30-8% the sum of the alkaline-earth metal oxides CaO+BaO moreover being between 8 and 15%, and the sum of the alkali metal oxides Na2O+K2O+Li2O moreover being between 7 and 20%. The reinforced glass-ceramics obtained by the process.
US08673460B2 Heterocyclic derivative and organic light emitting device using same
The present invention relates to a novel heterocyclic derivative and an organic light emitting device using the compound, and the heterocyclic derivative may largely improve a life span, efficiency, electrochemical stability and thermal stability of the organic light emitting device.
US08673458B2 Delayed fluorescence OLED
Novel organic compounds comprising a substituted anthracene or acridine ligand are provided. In particular, the compound includes an anthracene ligand substituted at the 9 and 10 positions. The compound may be used in organic light emitting devices to provide devices having improved efficiency and lifetime. In particular, these compounds may be especially beneficial for use in blue-emitting OLEDs.
US08673448B2 Articles containing precisely branched functional polymeric phase change materials
In accordance with one aspect a temperature regulating article comprises a substrate and a polymeric phase change material bound to the substrate, wherein the polymeric phase change material is characterized by including a precisely branched polymer with substantially equally spaced repeating sidechains. In other embodiments the polymeric phase change material includes between 20 and 200 branches per 1000 carbon units, has a latent heat of at least 5 Joules per gram, and a transition temperature between 0° C. and 40° C.
US08673444B2 Acrylic pressure-sensitive adhesive resin composition, and pressure-sensitive adhesive sheet or pressure-sensitive adhesive tape using the same
The present invention relates to an acrylic pressure-sensitive adhesive resin composition including an organic-inorganic hybrid polymer synthesized from the following (a) to (d): (a) fine silica particles having silanol groups on a surface thereof; (b) a siloxane having at least one selected from a group consisting of an alkoxysilyl group and a silanol group at a molecular end thereof; (c) a trialkoxysilane represented by the following general formula (I) in which R1 represents a C1-6 alkyl group, and R1′ represents a hydrogen atom or a methyl group; and (d) a (meth)acrylic monomer:
US08673443B2 Pressure-sensitive adhesive tape or sheet having light-reflective property and/or light-shielding property, and liquid crystal display apparatus
The present invention relates to a pressure-sensitive adhesive tape or sheet having a light-reflective property and/or a light-shielding property, which includes a base material and at least one pressure-sensitive adhesive layer disposed on at least one surface of the base material. The pressure-sensitive adhesive layer is formed by an acrylic pressure-sensitive adhesive composition containing an acrylic polymer (a) and a low-molecular weight polymer component (b) which contains, as a principal monomer component, an ethylenic unsaturated monomer having a glass transition temperature of from 60 to 190° C. when it is formed into a homopolymer and having a cyclic structure within the molecule thereof, and which has a weight-average molecular weight equal to or higher than 3,000 but lower than 20,000. The pressure-sensitive adhesive layer has a gel fraction of from 51 to 75 wt % and a temperature, at a maximum of loss tangent (tan δ), of from −14 to 25° C.
US08673437B2 Films having improved mechanical properties
A blown film having a thickness from 8 to 200 μm and dart drop impact DDI of more than 400 g, comprising a polyethylene molding composition having a multimodal molar mass distribution; a density from 0.940 to 0.948 g/cm3; an MFR190/5, from 0.10 to 0.50 dg/min; comprising: 40 to 60% of an ethylene homopolymer A having a molecular weight; 25 to 45% of a copolymer B of ethylene and at least one comonomer selected from the group of olefins having from 4 to 8 carbon atoms, said copolymer B having a molecular weight higher than said molecular weight of homopolymer A; and 10 to 30% of a copolymer C of ethylene and at least one comonomer, said copolymer C having a molecular weight higher than said molecular weight of copolymer B, all percentages being based on the total weight of the molding composition.
US08673434B2 PVD coated tool
The invention concerns a cutting tool comprising a main body and a multi-layer coating applied thereto. To provide improved cutting tools which have increased resistance to comb cracking, tribochemical wear and cratering caused thereby the main body comprises a hard metal which includes 5 to 8% by weight of Co, 0 to 2% by weight of TaC, 0 to 1% by weight of NbC and 89 to 95% by weight of WC with a mean grain size of 1 to 5 μm, and the coating has a first layer of TiAlN having a layer thickness of 1 to 5 μm, and a second layer of aluminum oxide having a layer thickness of 1 to 4 μm, wherein the coating further additionally includes on the second layer of aluminum oxide n alternately mutually superposedly applied layers of TiAlN and layers of aluminum oxide respectively having a layer thickness of 0.1 to 0.5 μm, wherein n relates to each individual layer and is an even number of 0 to 10, and wherein the total layer thickness of the coating is 2 to 16 μm and the coating is produced in the PVD process.
US08673431B2 Ink set for forming multilayer, ink jet recording method, and printed material
An ink set for forming a multilayer of the present invention includes a group of coloring ink compositions which include a yellow, a magenta, a cyan and a black ink composition, and a clear ink composition, wherein each of the coloring ink compositions contain a (component A) radical polymerizable compound, a (component B) radical polymerization initiator and a (component D) coloring agent, and the component A contains a (component A-1) N-vinyl compound and a (component A-2) specific ethylenic unsaturated compound (CTFA), the clear ink composition contains a (component A) radical polymerizable compound, a (component B) acylphosphine oxide-based photoinitiator and a (component C) surfactant, and the relation of 0.1≦(Y/X)<1 is satisfied when the content of the radical polymerization initiator in the clear ink composition is X, the content of the radical polymerization initiator in the magenta ink composition is Y.
US08673428B2 Engraved plate and substrate with conductor layer pattern using the same
An engraved plate which includes a substrate and an insulating layer on a surface of the substrate wherein a concave portion which increases in width toward an opening and to which the substrate is exposed is formed at the insulating layer, and an engraved plate, a substrate with conductor layer pattern manufactured by a transferring method using the engraved plate, and a conductor layer pattern are provided.
US08673423B2 Foaming composition for filling, foaming member for filling, and foam for filling
A foaming composition for filling contains a polymer, an organic peroxide, and azodicarbonamide, and a viscosity thereof measured at a temperature of 120° C. and under a pressure of 500 MPa with a flow tester is in a range of 1050 to 4950 Pa·s.
US08673421B2 Data disc, method and system of forming the disc
A data disc, method and apparatus for forming the disc are disclosed. The data disc includes a first substrate structure bonded to a second substrate structure, with two curable material layers disposed on different sides of at least one of the two substrate structures, and at least one groove formed on a surface of one of the two curable material layers.
US08673420B2 Master disc having a PTM layer and a nickel undercoat
The invention provides a master disc comprising a stack of a substrate, a phase transition material layer, a heat absorption layer provided between the substrate and the phase transition layer, and an anisotropic heat sink layer provided between the substrate and the absorption layer. Further, a method of manufacturing a master disc is provided. A stack having an upper side and a lower side is provided, wherein the stack comprises a substrate provided at the lower side of the stack, a phase transition material layer, a heat absorption layer provided between the substrate and the phase transition layer, and an anisotropic heat sink layer provided between the substrate and the absorption layer. The upper side of the stack is exposed to a laser beam and developed.
US08673416B2 Multilayer electrical component, coating composition, and method of making electrical component
Disclosed herein is an electrical component including a substrate comprising an electroconductive filler in a first polymeric binder, and a coating layer adhered to at least a portion of the substrate surface, the coating layer comprising a nanostructured electroconductive particulate dispersed in a polymeric binder, such as an epoxy resin. A method of making the component also is disclosed, comprising obtaining a substrate containing an electroconductive filler in a polymeric binder, dispersing a nanostructured electroconductive particulate filler in a liquid that includes a solvent and/or a reactive diluent to form a dispersion, mixing the dispersion with a liquid resin to form a coating mixture, applying the coating mixture to the substrate, and crosslinking the applied coating mixture to form the coated substrate.
US08673413B2 Method for packing solid organometallic compound and packed container
A method for packing a solid organometallic compound into a container for packing the compound is provided, wherein the solid organometallic compound can be stably supplied to a vapor phase epitaxial growth apparatus such as an MOCVD apparatus at a constant concentration for a long period of time. In the method for packing a solid organometallic compound into a container for packing, the compound is composed of grains having a grain size of 8 mm or less and the grains of the compound essentially comprise grains having a grain size of 2.5 to 6 mm.
US08673411B2 Liquid crystal composition and liquid crystal display device
Providing a liquid crystal composition satisfies at least one of characteristics like a high maximum temperature of a nematic phase, a low minimum temperature of the nematic phase, a small viscosity, a suitable optical anisotropy, a large negative dielectric anisotropy, a large specific resistance, a high stability to ultraviolet light and a high stability to heat. Providing a liquid crystal composition has a suitable balance regarding at least two of the characteristics. Providing an AM device has a short response time, a large voltage holding ratio, a large contrast ratio, a long service life and so forth. The liquid crystal composition has a negative dielectric anisotropy and contains a specific compound having a large negative dielectric anisotropy as a first component and a specific three-ring compound having a large optical anisotropy and a negative dielectric anisotropy as a second component, and a liquid crystal display device contains the composition.
US08673410B2 Adhesion layer for thin film transistors
A method for manufacturing a poly- or microcrystalline silicon layer on an insulator comprises a silicon containing insulator, growing a thin adhesion promoting layer comprising amorphous silicon onto it and further growing a poly- or microcrystalline silicon layer onto the adhesion promoting layer. Such a sequence of layers, deposited with a PECVD method, shows good adhesion of the poly- or microcrystalline silicon on the base and is advantageous in the production of semiconductors, such as thin film transistors.
US08673406B2 Method and device for the plasma treatment of surfaces containing alkali and alkaline-earth metals
The invention relates to a method for the plasma treatment of glass surfaces, the metal component, in particular the alkali and/or alkaline-earth metal component in the superficial region of the substrate being reduced by a plasma treatment of a substrate.
US08673401B2 Gallium ink and methods of making and using same
A method for depositing gallium using a gallium ink, comprising, as initial components: a gallium component comprising gallium; a stabilizing component; an additive; and, a liquid carrier; is provided comprising applying the gallium ink on the substrate; heating the applied gallium ink to eliminate the additive and the liquid carrier, depositing gallium on the substrate; and, optionally, annealing the deposited gallium.
US08673396B2 Method of forming continuous thin film and linear glass substrate with thin film
A method of continuously forming a thin film includes the step of: moving a glass substrate with a thin strip shape having a constant db/2(d+b), where d is a thickness thereof and b is a width thereof in a cross section thereof, within a range from 0.015 to 0.15 through a film depositing region in which a reaction gas is supplied and a temperature is controlled to be high so that the glass substrate is rapidly heated; and moving continuously the glass substrate, immediately after the film depositing region, to pass through a cooling region in which a temperature is lower than that of the film depositing region, so that the glass substrate is rapidly cooled and the thin film formed of a component of the reaction gas is formed on the glass substrate.
US08673387B2 Coated medical device
A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
US08673386B2 Composition for glucose sensing comprising of nanofibrous membrane and method for manufacturing non-enzymatic glucose biosensor using the same
Disclosed herein is a composition for glucose sensing obtained by dispersing in a solvent such as acetone a nanofibrous membrane fabricated by electrospinning a mixture containing poly(vinylidene fluoride) and poly(aminophenylboronic acid). Also disclosed is a method of fabricating a non-enzymatic glucose biosensor based on an electrospun nanofibrous membrane by depositing the composition on an electrode.
US08673384B2 Oral cavity stimulating substance
A novel compound causing an oral cavity stimulus such as acridness, which is expressed by the following structural formula (I):
US08673381B2 Free flowing vegetable powder and method for its manufacture
A free flowing vegetable powder comprises an intimate mixture of at least three different dehydrated vegetables including: 5-60% of onion by weight of vegetable dry matter; 20-90% by weight of vegetable dry matter of moderately colored vegetable selected from the group consisting of vegetables belonging to the genus Cucurbita, vegetables belonging to the genus Oleracea, sweet corn, sweet potato, green bean, edamame, celery and combinations thereof; and 5-75% by weight of vegetable dry matter of intensely colored vegetable selected from the group consisting of tomato, red bell pepper, red beet, radicchio, swiss chard, rhubarb, peppers, yam, Adzuki beans, carrot, green pea, green bell pepper, asparagus, spinach, Brussels sprouts, kale, egg plant and combinations thereof. The vegetable powder according to the present invention can advantageously be employed in fabricated savory snacks to deliver nutritional benefit, a considerable vegetable serving size, color and taste.
US08673377B2 Method for extending mold-free shelf life and improving flavor characteristics of baked goods
The present invention provides a novel method for extending mold-free shelf life and for improving the flavor of baked goods by applying live yeast on the surface of the baked good after baking and cooling before packaging the baked good in closed bags and storing the packaged baked goods at ambient temperature. This method can be used for all kinds of baked goods including breads, rolls, bagels, pizza crusts, wheat flour tortillas, croissants, cakes, muffins, donuts and pita breads. This method can also be used to produce baked goods containing live probiotic yeast (Saccharomyces cerevisiae var. boulardii ).
US08673376B2 Polyphenol-containing composition for oral administration or external use and use of same
A composition including a strawberry-derived polyphenol highly effective for oral administration or external use. A composition for oral administration or external use is obtained by subjecting a hot water extract of strawberry to adsorption chromatography using an aromatic synthetic absorbent, removing the fractions passing through the column and fractions eluted with water, and then eluting with a 5 to 60% aqueous ethanol solution.
US08673374B1 Composite essential oil for expanding corpus cavernosum
A composite essential oil for expanding corpus cavernosum is composed of 30˜50 parts of a cinnamon essential oil, 20˜40 parts of a black pepper essential oil, 40˜60 parts of a juniper essential oil, 20-40 parts of a ginger essential oil, 0˜30 parts of a jasmine essential oil and 0-20 parts of a clove essential oil by volume and provided for overcoming a men's health problem, particularly the erectile dysfunction.
US08673371B2 Composition for treating vitiligo or canities comprising extract from sophora japonica as active ingredient
Disclosed is a composition for treating or preventing vitiligo or canities comprising Sophora japonica extract as an active ingredient. The Sophora japonica extract enhances melanin synthesis by increasing the activity of tyrosinase which is critical in intracellular melanin synthesis and promoting the expression of tyrosinase and TRP-2 mRNA. Furthermore, since the Sophora japonica extract is a natural substance with little cytotoxicity, it may be developed into a therapeutic agent for vitiligo and canities caused by depigmentation in skin and hair.
US08673364B2 Rapid setting high strength calcium phosphate cements comprising cyclodextrins
Rapid setting high strength calcium phosphate cements and methods of using the same are provided. Aspects of the cements include fine and coarse calcium phosphate particulate reactants and a cyclodextrin which, upon combination with a setting fluid, produce a flowable composition that rapidly sets into a high strength product. The flowable compositions find use in a variety of different applications, including the repair of hard tissue defects, e.g., bone defects such as fractures.
US08673361B2 Cytokine modulating composition
The invention relates to an agent having cytokine mediating activity. In particular the invention relates to a composition comprising a fraction of denatured plasma proteins and at least one metal, metal ion or metal salt thereof, wherein said mixture has cytokine mediating activity.
US08673358B2 Nano-carrier, complex of anticancer drug and nano-carrier, pharmaceutical composition thereof, method for manufacturing the complex, and method for treating cancer by using the pharmaceutical composition
The present invention relates to a nano-carrier for an anticancer drug, which comprises: a metal nanoparticle; and a polynucleotide for connecting with an anticancer drug having a pyrimidine group or a purine group, wherein the polynucleotide connects to a surface of the metal nanoparticle, and the anticancer drug binds to the polynucleotide through the pyrimidine group or the purine group. In addition, the present invention also provides a complex of an anticancer drug and a nano-carrier, a pharmaceutical composition thereof, a method for manufacturing the complex, and a method for treating a cancer by using the pharmaceutical composition.
US08673351B2 Crystallization inhibitor and its use in gelatin capsules
The present invention describes soft gelatin capsules that encapsulate a water-insoluble active ingredient and an excipient composed of a crystallization inhibitor that stabilizes the water-insoluble inhibitor. The crystallization inhibitor being at least one mononacylglycerol compound whose acyl group is a fatty acid residue of 6-18 carbon atoms. The capsule contents are more resistant to turbidity, forming a coarse emulsion, and crystallization of the active ingredient compared with compositions absent the crystallization inhibitor.
US08673350B2 Pharmaceutical formulations
The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.
US08673347B2 Polymer conjugates of K-252A and derivatives thereof
The present invention relates to novel polymer conjugates of K-252a and derivatives thereof and to their use for the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of kinase-associated pathologies. In particular, the present invention relates to the prevention, alleviation and treatment of HMGB1-associated pathologies. The invention relates to the use of the novel polymer conjugates of K-252a and derivatives thereof in the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of a) neurological disorders, neuropathies and neurodegenerative disorders of the central and peripheral nervous system; b) dermal pathologies, in particular dermal pathologies associated with an excessive keratinocyte proliferation, in particular psoriasis; and c) NGF-related pain. More specifically, the present invention relates to a polymer conjugate of K-252a and derivatives thereof, wherein the polymer is polyethylene glycol or methoxy-polyethylene glycol formula (I).
US08673346B2 Transdermal drug delivery method and system
The invention concerns a transdermal delivery system for controlled dispensing of an active substance to and through a porous surface. A certain amount of fluid comprising at least one active substance and at least one solvent is dispensed into an administration reservoir. In the administration reservoir the at least one solvent is separated from the administration reservoir by a solvent recovery means such that the active substance achieves a certain level on an interface device which is permeable for the one active substance. Thereby the active substance is absorbable via diffusion from the interface device by a porous surface to be treated.
US08673345B2 Dissolvable film composition
A kit and methods for delivering an effective amount of a labile active to the skin are provided. The kit and methods comprise a composition comprising an effective amount of a labile active agent incorporated into a water-soluble polymeric film and an additive composition capable of dissolving the water-soluble polymeric film.
US08673344B2 Solid dosage form with a film containing an active substance, as well as its method of production
The present invention relates to a solid dosage form with at least one film, which contains an active substance at least in sections, and the concentration of the active substance in the film or in the films has a gradient in a direction normal to the thickness of film. The invention further relates to a method of producing a solid dosage form, in which at least one film is produced, containing an active substance at least in sections, with the concentration of the active substance having a gradient in the longitudinal direction of the film.
US08673341B2 Intraocular pressure reduction with intracameral bimatoprost implants
The present invention provides a method of treating an ocular condition in an eye of a patient, comprising the step of placing a biodegradable intraocular implant in an eye of the patient, the implant comprising a prostamide and a biodegradable polymer matrix that releases drug at a rate effective to sustain release of an amount of the prostamide from the implant to provide an amount of the prostamide effective to prevent or reduce a symptom of an ocular condition of the eye, wherein said ocular condition is elevated IOP and said implant is placed in an intracameral location to dilate the outflow channels of the eye emanating from Schlemm's Canal.
US08673339B2 Demand-release bioactive composition for implantable medical devices
A biostable polymeric substrate of an implantable medical device unit includes a demand-release bioactive composition including one or more bioactive agents covalently bound to surface-modifying end groups of the substrate. Certain cellular activities, in proximity to the polymeric substrate, release substances reacting with the end groups such that the end groups release the one or more bioactive agents, which modify the certain cellular activities.
US08673338B2 Methods of delivering pharmaceutical agents
Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological disorder or pain in a subject that include administering at least one pharmaceutical agent onto a SEM graft in the skull base of the subject. Also provided are methods of treating a neurological disorder or pain in a subject that include forming a SEM graft in the skull base of the subject and administering at least one pharmaceutical agent onto the SEM graft in the skull base of the subject. Also provided are methods of forming a SEM graft in the skull base of a subject, compositions for administration onto a SEM graft in the skull base or into an endonasal reservoir or endonasal reservoir device in a subject, and devices for administering such compositions onto a SEM graft in the skull base of a subject.
US08673337B2 Method of tissue repair using a composite material
A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.
US08673335B2 Methods and compositions for sealing and adhering biological tissues and medical uses thereof
Compositions and methods for sealing, coating and adhering tissues are provided that utilize a polymeric system comprising at least a Polymer and a crosslinking agent; and, optionally, (i) a Gelation Disrupting Agent, (ii) an Augmentative Polymer or Monomer, (iii) an Adjunct Compound (iv) an Antimicrobial Agent (v) an Adhesion Enhancer, (vi) a Crosslink Augmentating Agent or any combination thereof. Additionally, a Therapeutic Agent may be incorporated.
US08673330B2 Insecticidal compositions suitable for use in preparation of insecticidal granular fertilizer and insecticidal formulations
Insecticidal compositions suitable for use in preparation of insecticidal granular fertilizer and insecticidal formulations comprising a pyrethroid and a glycol present in a concentration of from 40.0% by weight to 99.0% by weight based upon the total weight of all components in the composition is disclosed.
US08673321B2 Cyclophosphamide in combination with anti-idiotypic vaccines
The present invention relates to methods of treating a cancer and in particular, a B-cell derived cancer, using a lymphocytotoxic but hematopoeitic cell sparing high-dose pulsed amount of an oxazaphosphorine drug in combination with immune therapeutics such as, for example, an autologous idiotypic vaccine and monoclonal antibodies that selectively bind B-cell specific antigens.
US08673320B2 Metal-citrate transporter antigen from Streptomyces coelicolor and uses thereof
The present invention relates to an isolated antigen from Streptomyces coelicolor that is useful for developing, inter alia, vaccines against pathogenic bacteria of humans and animals. The present invention also relates to vaccines and antibodies developed using the isolated antigen. The present invention also relates to methods of using the antigen, vaccines, and antibodies of the present invention to detect, treat, and prevent infection and diseases associated with pathogenic bacteria.
US08673319B2 Chimpanzee adenovirus vaccine carriers
The present invention provides recombinant replication-defective adenoviral vectors derived from chimpanzee adenoviruses and methods for generating recombinant adenoviruses in human E1-expressing cell lines. The invention also provides compositions and methods suitable for use for the delivery and expression of transgenes encoding immunogens against which a boosted immune response is desired. The invention further provides methods of generating clinical grade vector stocks suitable for use in humans. In a particular embodiment the invention contemplates the use of vectors comprising transgenes which encode tumor associated antigens in vaccines and pharmaceutical compositions for the prevention and treatment of cancer.
US08673316B2 Avirulent, immunogenic flavivirus chimeras
Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural viral proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
US08673315B2 Method for producing vaccinal viral strain of a virus of the reoviridae family
The invention relates to a method for producing a modified viral strain of a virus which is a member of the Reoviridae family and, in particular, relates to vaccinal viral strains of the Orbivirus genus.
US08673314B2 Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof
Provided herein are methods of producing neutralizing monoclonal antibodies, by cyclical immunization, that cross-react with strains of Influenza virus of the same subtype or different subtypes. Also provided herein are compositions comprising such antibodies and methods of using such antibodies to diagnose, prevent or treat Influenza virus disease.
US08673312B2 Method for one-step purification of recombinant Helicobacter pylori neutrophil-activating protein
Helicobacter pylori is closely associated with chronic gastritis, peptic ulcer disease, and gastric adenocarcinoma. Helicobacter pylori neutrophil-activating protein (HP-NAP), a virulence factor of Helicobacter pylori, plays an important role in pathogenesis of Helicobacter pylori infection. Since HP-NAP has been proposed as a candidate vaccine against Helicobacter pylori infection, an efficient way to obtain pure HP-NAP needs to be developed. In the present invention, recombinant HP-NAP expressed in Bacillus subtilis and Escherichia coli was purified through a single step of DEAE SEPHADEX ion-exchange chromatography with high purity. Also, purified recombinant HP-NAP was able to stimulate neutrophils to produce reactive oxygen species. Thus, recombinant HP-NAP obtained from our Bacillus subtilis expression system and Escherichia coli expression system is functionally active. Furthermore, this one-step negative purification method should provide an efficient way to purify recombinant HP-NAP expressed in Bacillus subtilis and Escherichia coli for basic studies, vaccine development, or drug design.
US08673310B2 Stable and soluble antibodies inhibiting TNFα
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF-mediated disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
US08673307B1 HIV-1 anti-core neutralizing antibodies that target a conformational epitope within the ALPHA5-helix of GP120
Broad neutralizing antibodies directed to epitopes of Human Immunodeficiency Virus, or HIV, especially the preparation and use of highly neutralizing antibodies directed to HIV gp120 envelope protein, in the vaccination and treatment of HIV-infected patients.
US08673304B2 Humanized anti-CD4 antibody with immunosuppressive properties
A humanized antibody derived from mouse monoclonal anti-CD4 antibody B-F5 is able to activate CD25+CD4+ regulatory T cells and is useful for preparing immunosuppressive compositions.
US08673302B2 Anti-cMet antibody and its use for the detection and the diagnosis of cancer
The present invention relates to the field of prognosis and/or diagnosis of a proliferative disease in a patient. More particularly, the invention relates to antibodies capable of binding to the human cMet receptor, as well as the amino acid and nucleic acid sequences coding for these antibodies. The invention likewise comprises the use of said antibodies, and corresponding processes, for detecting and diagnosing pathological hyperproliterative oncogenic disorders associated with expression of cMet. In certain embodiments, the disorders are oncogenic disorders associated with increased expression of cMet polypeptide relative to normal or any other pathology connected with the overexpression of cMet. The invention finally comprises products and/or compositions or kits comprising at least such antibodies for the prognosis or diagnostic of certain cancers.
US08673301B2 YKL-40 monoclonal antibody
The present invention relates to monoclonal anti-human YKL-antibodies which are capable to modulate biological processes in which YKL-40 plays a prominent role, e.g. inhibit the growth and/or inducing apoptosis of cells, in particular cancer cells. The invention also relates to pharmaceutical compositions comprising said antibodies and uses said antibodies and/or pharmaceutical compositions for treatment of a disease wherein inhibition of cell growth, cell differentiation, remodelling of extracellular matrix, metastasis and/or induction of cell death due to apoptosis is a prerequisite for successful curing. An antibody of the invention is capable of inhibiting biological function of YKL-40 in the above mentioned processes by binding to a specific epitope on YKL-40.
US08673300B2 Therapeutic compositions and methods for the prevention of autoimmune diseases
Antibodies specific for an MHC class II-autoantigen complex.
US08673298B2 Stabilized compositions of proteins having a free thiol moeity
Compositions of proteins having free thiols, and methods of making and using such compositions, are described.
US08673294B2 Immunoisolation patch system for cellular transplantation
An immunoisolation patch system, and particularly a patch system comprising multiple immunoisolation microcapsules, each encapsulating biological material such as cells for transplantation, which can be used in the prophylactic and therapeutic treatment of disease in large animals and humans without the need for immunosuppression.
US08673293B2 Use of modified cells for the treatment of multiple sclerosis
The present invention describes blood cells chemically coupled with immunodominant myelin peptides and their use in the treatment of Multiple Sclerosis.
US08673285B2 Sphingoid polyalkylamine conjugates for vaccination
The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for modulating the immune response of a subject. Other aspects of the invention concern methods for modulating the immune response of a subject by the use of the conjugate, complexes comprising, the sphingoid-polyalkylamine conjugate in combination with a biologically active molecule capable of modulating an immune response of a subject, compositions comprising the conjugate as well as kits making use of said conjugate. A preferred conjugate according to the invention is N palmitoyl D-erythro sphingosyl 1 carbamoyl spermine.
US08673283B2 Cosmetic compositions containing block copolymers, tackifiers and a solvent mixture
A cosmetic composition containing at least one block copolymer having at least one hard segment and at least one soft segment, at least one tackifier component, a solvent mixture, and optionally, at least one colorant, and wherein the at least one hard segment has a Tg value of 50° C. or more, the at least one soft segment has a Tg value of 20° C. or less, and wherein the solvent mixture contains at least one solvent capable of solubilizing the at least one hard segment, and at least one solvent capable of solubilizing the at least one soft segment.
US08673281B2 Pharmaceutical composition for intracellular acidification with cis-urocanic acid
A pharmaceutically acceptable agent able to acidify the cell cytoplasm, for the manufacture of a pharmaceutical composition useful for causing immunosuppression in a person or animal, where an effective amount of the agent is administered in an essentially non-dissociated form to the person or animal, and where the agent is admixed with a carrier to adjust the pH of the composition to the pH range 6.1 to 7.0. A pharmaceutical composition is also disclosed.
US08673280B2 Pharmaceutical composition for intracellar acidification with cis-urocanic acid
A pharmaceutically acceptable agent able to acidify the cell cytoplasm for the manufacture of a pharmaceutical composition useful for causing immunosuppression in a person or animal, where an effective amount of the agent is administered in an essentially non-dissociated form to the person or animal, and where the agent is admixed with a carrier to adjust the pH of the composition to the pH range 6.1 to 7.0. A pharmaceutical composition is also disclosed.
US08673277B2 Structured acrylate copolymer thickeners
Disclosed are multi-staged acrylic based core-shell polymers comprising a linear core polymer and at least one subsequently polymerized shell polymers is crosslinked. The core-shell polymers surprisingly provide desirable rheological, clarity, and aesthetic properties in aqueous surfactant containing compositions, particularly at low pH.
US08673272B2 Ultraviolet-absorbing compounds
Disclosed are novel ultraviolet-absorbing compounds produced by two embodiments. By a first embodiment, the ultraviolet-absorbing compound is derived from at a first reactant being a UV absorber comprising a carbon-nitrogen triple bond and a second reactant having amine functionality. By a second embodiment, the ultraviolet-absorbing compound is derived from a first reactant being a UV absorber comprising amine functionality and a second reactant comprising a carbon-nitrogen triple bond. In both embodiments of the invention, the second reactant may be a small molecule, a monomer, a macromolecule, a biomolecule, or a polymer.The invention's ultraviolet-absorbing compounds are directed toward formulations and applications that serve to protect against UV radiation in any art. Exemplary uses of the ultraviolet-absorbing compounds are in adhesive, agriculture, cleaning/polishing, coating, containers, encapsulation, fragrances, imaging, hoses/tubing, household/industrial/institutional, medical, membrane, molded parts, oilfield, packaging, personal care, personal protective equipment, pharmaceutical, printing, veterinary, and wood-care applications. Highly preferred uses of the ultraviolet-absorbing compounds are in personal care and performance chemicals. wherein R═
US08673269B2 Halogenated phenols for diagnostics, antioxidant protection and drug delivery
The present invention relates to a composition and method for the detection of a detectable product formed from a compound of the present invention in the body of an individual. The detectable product may include a halide or a benzenetriol-based or benzenetetrol-based product of a dehalogenation reaction in the presence of FROS. In many embodiments, an indigo-like product formed from an indigogenic compound of the present invention may also be a detectable product for diagnostic purposes. This indigo-like product may have a higher residence time in tissues where it is formed, thus providing a detectable product localized to sites of high FROS. An indigogenic compound containing one or more radioactive isotopes is further provided for therapeutic purposes.
US08673267B2 Methods and products for in vivo enzyme profiling
The present invention relates to methods and products associated with in vivo enzyme profiling. In particular, the invention relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence of active enzymes associated with diseases or conditions. The invention also relates to products, kits, and databases for use in the methods of the invention.
US08673259B2 Apparatus and method for substrate and gas heating during chemical vapor deposition nanotube synthesis
Apparatus and methods are described for separate heating of substrate, catalyst and feedstock/transport gases for the controllable CVD synthesis of various carbon nanotubes and nanostructures, and particularly for CVD growth of oriented forests of multi-wall CNT forests, which are highly dry-spinnable into sheets and yarns.
US08673257B2 Apparatus and method to sequester contaminants
The invention relates to an apparatus and method for reducing contaminants from industrial processes. More particularly, the invention is directed to a method of sequestering pollutants from flue gases in operational plants. The method includes sequestering contaminants from a point source by reacting an alkaline material with a flue gas containing contaminants to be sequestered, wherein the reaction has a rapid mass transfer rate to sequester at least a portion of the contaminants.
US08673254B2 Monocrystalline silicon carbide ingot, monocrystalline silicon carbide wafer and method of manufacturing the same
Provided is a monocrystalline silicon carbide ingot containing a dopant element, wherein a maximum concentration of the dopant element is less than 5×1017 atoms/cm3 and the maximum concentration is 50 times or less than that of a minimum concentration of the dopant element. Also provided is a monocrystalline silicon carbide wafer made by cutting and polishing the monocrystalline silicon carbide ingot, wherein a electric resistivity at room temperature of the wafer is 5×103 Ωcm or more. Further provided is a method for manufacturing the monocrystalline silicon carbide including growing the monocrystalline silicon carbide on a seed crystal from a sublimation material by a sublimation method. The sublimation material includes a solid material containing a dopant element, and the specific surface of the solid material containing the dopant element is 0.5 m2/g or less.
US08673253B2 Amorphous silicon-containing material with hierarchical porosity
Material with hierarchical porosity consisting of at least two elementary spherical particles having a maximum diameter of 200 microns, at least one of said spherical particles comprising at least one matrix based on silicon oxide, said material having a macropore volume measured by mercury porosimetry ranging between 0.05 and 1 ml/g, a mesopore volume measured by nitrogen volumetric analysis ranging between 0.01 and 1 ml/g and a micropore volume measured by nitrogen volumetric analysis ranging between 0.03 and 0.4 ml/g, said matrix having amorphous walls. The preparation of said material is also described.
US08673248B2 Silicon material with controlled agglomerated point defects and oxygen clusters induced by the lateral surface
The present invention relates to a single crystal silicon ingot or wafer wherein the lateral incorporation effect of intrinsic point defects has been manipulated such that the formation of agglomerated intrinsic point defects and/or oxygen precipitate clusters in a ring extending radially inward from about the lateral surface of the ingot segment is limited.
US08673246B2 Process for contacting one or more fluids and a reactor relating thereto
One exemplary embodiment can be a process for contacting one or more fluids in a vessel. The process may include passing one or more fluids into a chamber from an overhead tray and providing a conduit outside the chamber coupling a respective spillway to a respective hole for increasing contact time inside the conduit. Typically, the chamber forms one or more sidewalls forming at least one hole and the overhead tray forms at least one spillway.
US08673242B2 Over-torque resistant vial
An over-torque resistant vial and closure assembly includes a vial having an outwardly projecting rib that cooperates with a stop surface provided on a closure. When the closure is threadably coupled to the vial, the stop surface of the closure engages the outwardly projecting rib of the vial so as to prevent over-torquing of the closure onto the vial.
US08673239B2 Sample collector and test device
A sample collector and test device is disclosed. The sample collector and test device may be used together as a diagnostic tool for collecting and assay of analytes contained in a sample. A sample collector is also disclosed which may be used with existing sample containers and or test devices. The sample collector may indicate sample adequacy when a sufficient volume of sample has been collected for assay and may also include a sample retaining feature which retains a portion of expressed sample for confirmatory testing, if desirable. The sample collector may also include a mechanism for expressing sample in a sample collector and/or test device. A test device is also disclosed for retaining and assay of an expressed sample. The disclosed test device may be used with existing sample collectors. In a preferred embodiment, test device is used with a preferred sample collector. Test device may include a locking feature for locking a sample retained on a sample collector or test device may be used to receive expressed sample collected from a syringe or another suitable sample delivery device.
US08673236B2 Water soluble film based matrix to collect samples extracted from living species
The invention relates to a water soluble film based matrix for collecting blood samples, urine samples, serum samples or any other type of samples extracted from living species; so as to avoid cross infection or spillage of samples during transportation of said samples. These samples can then used for further detection of virus, bacteria, finding new molecules, diagnosing genes or extraction of DNA. Also, said matrix will dissolve during analysis of the sample and thus there will be no disposal problems.
US08673235B2 Sconce for a fragrance dispenser
A dispenser assembly for supporting a fragrance control unit comprising a canister and a controller or comprising a wafer support plate, fragrance wafers and a fan unit are disclosed. The controller includes a timer, a computer program for the dispersing rate, and a mechanism for activating a spray mechanism of the canister. An embodiment includes a back plate pivotally connected to a front sconce cover and having a tapered structure. Further embodiments include a sconce cover and back plate wherein studs in the sconce cover enter the back plate and the sconce cover is slid upwardly along the back plate and secured in place. Slits in the sconce cover and a top opening allows dispersion of the fragrance. Further embodiments include a sconce cover hinged to the back plate. The sconce cover includes logos and/or decorative designs, e.g. bronco, Southwestern pottery and floral arrangements with slits for dispersing the fragrance.
US08673228B2 System for reducing environmental pollutants
The system for reducing environmental pollutants according to the present invention comprises: a first water immersion tank for producing strongly alkaline water by receiving a supply of bottom ash, which has been created by and has been accumulated at the bottom of a combustion furnace, and reacting it with water accommodated on its inside; an elimination reaction tank which is provided on a combustion pathway extending from the combustion furnace, and which internally accommodates the strongly alkaline water supplied from the first water immersion tank, and which also eliminates carbon-based compounds contained in exhaust gases which are discharged through the combustion pathway; a sludge-storage tank for receiving and storing sludge which has been produced as a consequence of the elimination reaction within the elimination reaction tank; a first aggregate storage tank for receiving and storing bottom-ash aggregate remaining within the first water immersion tank after the neutralization which follows as a consequence of the production of the strongly alkaline water; and a second water immersion tank for supplying the elimination reaction tank with strongly alkaline water which is produced by reacting water, accommodated on its inside, with a supply of fly ash which has been generated by the combustion furnace and has accumulated in a dust-collecting device on the combustion pathway.
US08673226B2 Apparatus and method for forming hydrated lime
An apparatus and method for hydrating lime in a horizontally disposed vessel where adjacent oppositely rotating shafts have first sets of spaced blades extending coaxially with an axis of each shaft and an adjacent second set of blades extending to an angle to the longitudinal axis, the blades directing a mixture of quicklime and water upwardly into a space between the shafts and towards the cover, while forming hydrated lime.
US08673224B2 Apparatus for synthesis and assaying of materials
An apparatus for synthesis and assaying of materials is provided that significantly improves throughput efficiency by allowing for material synthesis and assaying in the same assembly while possessing the ability to reach higher pressures and higher temperatures than existing designs capable of synthesis and assaying in the same assembly. In addition, the apparatus provides for gas flow over the material sample, allowing for a number of materials to be synthesized within the apparatus by gas synthesis.
US08673220B2 Reactors for conducting thermochemical processes with solar heat input, and associated systems and methods
Reactors for conducting thermochemical processes with solar heat input, and associated systems and methods. A representative system includes a reactor having a reaction zone, a reactant source coupled in fluid in communication with the reactant zone, and a solar concentrator having at least one concentrator surface positionable to direct solar energy to a focal area. The system can further include an actuator coupled to the solar concentrator to move the solar concentrator relative to the sun, and a controller operatively coupled to the actuator. The controller can be programmed with instructions that direct the actuator to position the solar concentrator to focus the solar energy on the reaction zone when the solar energy is above a threshold level, and point to a location in the sky having relatively little radiant energy to cool an object when the solar energy is below the threshold level.
US08673219B2 Nasal passage insertion device for treatment of ruminant exhalations
Methane gas in a ruminant exhalation may be oxidized to reduce the amount of methane gas output by the ruminant.
US08673215B2 Test device for platelet aggregation detection
The invention relates to the test device for platelet aggregation detection comprising: —an element (1) for receiving a blood sample—a capillary tube (3) connected at a first end (31) to said element (1) and at a second end (32) to a pressure lowering device (5) to pump said blood sample through said capillary tube (3)—at least a pair of facing electrodes (8) on the capillary tube—a device for measuring an impedance between said pair of facing electrodes. The invention also relates to a process for using this device, comprising: a) receiving a blood sample and pumping it through the capillar tube (3) b) determining a dynamic change of the value of the impedance between at least one pair of electrodes (8).
US08673209B2 Aluminum alloy products having improved property combinations and method for artificially aging same
Aluminum alloy products about 4 inches thick or less that possesses the ability to achieve, when solution heat treated, quenched, and artificially aged, and in parts made from the products, an improved combination of strength, fracture toughness and corrosion resistance, the alloy consisting essentially of: about 6.8 to about 8.5 wt. % Zn, about 1.5 to about 2.00 wt. % Mg, about 1.75 to about 2.3 wt. % Cu; about 0.05 to about 0.3 wt. % Zr, less than about 0.1 wt. % Mn, less than about 0.05 wt. % Cr, the balance Al, incidental elements and impurities and a method for making same. The invention alloy is useful in making structural members for commercial airplanes including, but not limited to, upper wing skins and stringers, spar caps, spar webs and ribs of either built-up or integral construction. The invention alloy may be aged by 2 or 3 step practices while exceeding the SCC requirements for applications for which the invention alloy is primarily intended. The flexibility of the invention in this regard is useful for its application in multi-alloy or multi-material systems joined by welding or bonding and subsequently aged.
US08673208B2 Process and equipment for the production of direct reduced iron and/or pig iron from iron ores having a high-phosphorus content
A process and apparatus for refining iron from high-phosphorus content iron ores. The process involves mixing a high-phosphorus iron oxide ore and an alkaline solution of pH between about 12.5 and 13.5, screening the mixture by gravity to separate an alkaline-high-phosphorus solution from a low-phosphorus iron ore; and treating the low-phosphorus iron ore with lime and a natural gas.
US08673207B1 Porous ceramic honeycomb articles and methods for making the same
A porous ceramic honeycomb article comprising a honeycomb body formed from cordierite ceramic, wherein the honeycomb body has a porosity P %≧55% and a cell channel density CD≧150 cpsi. The porous channel walls have a wall thickness T, wherein (11+(300−CD)*0.03)≧T≧(8+(300−CD)*0.02), a median pore size ≦20 microns, and a pore size distribution with a d-factor of ≦0.35. The honeycomb body has a specific pore volume of VP≦0.22. The porous ceramic honeycomb article exhibits a coated pressure drop increase of ≦8 kPa at a flow rate of 26.5 cubic feet per minute when coated with 100 g/L of a washcoat catalyst and loaded with 5 g/L of soot.
US08673196B2 Radial seal filter with open end pleats
A filter, comprising: a filter element comprising pleated filter media having a plurality of pleats configured into a closed loop of filter media, the filter element having an outer perimeter defined by a plurality of outer pleat tips, and an inner perimeter defined by a plurality of inner pleat tips, the plurality of inner pleat tips defining an inner chamber extending through the filter element; a cap disposed on a first end of the filter element the cap being configured to seal a first opening of the first end of the filter; a first plurality of open end pleats positioned between an edge of the cap and the outer perimeter of the filter element, the first plurality of open end pleats defining a first fluid path through the filter media into the inner chamber; a sealing ring disposed on a second end of the filter element the sealing ring being configured to provide an inlet opening providing fluid communication to the inner chamber; and a second plurality of open end pleats positioned between an edge of the sealing ring and the outer perimeter of the filter element, the second plurality of open end pleats defining a second fluid path through the filter media into the inner chamber.
US08673185B2 Device comprising positive hole injection transport layer, method for producing the same and ink for forming positive hole injection transport layer
The present invention is to provide a device capable of having an easy production process and achieving a long lifetime. A device comprising a substrate, two or more electrodes facing each other disposed on the substrate and a positive hole injection transport layer disposed between two electrodes among the two or more electrodes, wherein the positive hole injection transport layer comprises a transition metal-containing nanoparticle containing at least a transition metal compound including a transition metal oxide, a transition metal and a protecting agent, or at least the transition metal compound including the transition metal oxide, and the protecting agent.
US08673179B2 Scintillation materials of low oxygen content and process for producing same
The scintillation material has a maximum oxygen content of 2,500 ppm and is a compound of formula LnX3 or LnX3:D, wherein Ln is at least one rare earth element, X is F, Cl, Br, or I; and D is at least one cationic dopant of one or more of the elements Y, Zr, Pd, Hf and Bi and, if present, is present in an amount of 10 ppm to 10,000 ppm. The process of making the scintillation material includes optionally mixing the compound of the formula LnX3 with the at least one cationic dopant, heating the compound or the mixture so obtained to a melting temperature to form a melt, adding one or more carbon halides and then cooling the melt to form a crystal or crystalline structure. The maximum oxygen content of the scintillation material is preferably 1000 ppm.
US08673178B2 Liquid crystal medium
The invention relates to compounds of the formula I in which R0, A0, A1, A2, Z0, Z1, Z2, L1, L2, X, l, m and n have the meanings indicated in claim 1, and to the use thereof in liquid-crystalline media, and to liquid-crystalline media comprising one or more compounds of the formula I in electro-optical liquid-crystal displays.
US08673176B2 Method of reusing micro-encapsulated cholesteric liquid crystal
A method of reusing micro-encapsulated cholesteric liquid crystals is provided. The method includes providing a display medium material containing a micro-encapsulated cholesteric liquid crystal and a dispersant. The display medium material is mixed with a solvent to form a mixture having a temperature of between 40° C. and 60° C. A centrifugal process is performed to the mixture for separating the micro-encapsulated cholesteric liquid crystal and the dispersant. Then, the dispersant and the solvent are removed to obtain the micro-encapsulated cholesteric liquid crystal.
US08673170B2 Non-homogenous positive electrode materials combining high safety and high power in a Li rechargeable battery
The invention relates to a LiaNixCoyMzO2±eAf composite oxide for use as a cathode material in a rechargeable battery, with a non-homogenous Ni/Al ratio in the particles, allowing excellent power and safety properties when used as positive electrode material in Li battery. More particularly, in the formula 0.9
US08673165B2 Sidewall image transfer process with multiple critical dimensions
Embodiment of the present invention provides a method of forming a semiconductor device in a sidewall image transfer process with multiple critical dimensions. The method includes forming a multi-level dielectric layer over a plurality of mandrels, the multi-level dielectric layer having a plurality of regions covering the plurality of mandrels, the plurality of regions of the multi-level dielectric layer having different thicknesses; etching the plurality of regions of the multi-level dielectric layer into spacers by applying a directional etching process, the spacers being formed next to sidewalls of the plurality of mandrels and having different widths corresponding to the different thicknesses of the plurality of regions of the multi-level dielectric layer; removing the plurality of mandrels in-between the spacers; and transferring bottom images of the spacers into one or more layers underneath the spacers.
US08673163B2 Method for fabricating thin sheets of glass
Fabrication of thin sheets of glass or other substrate material for use in devices such as touch sensor panels is disclosed. A pair of thick glass sheets, typically with thicknesses of 0.5 mm or greater each, may each be patterned with thin film on a surface, sealed together to form a sandwich with the patterned surfaces facing each other and spaced apart by removable spacers, either or both thinned on their outside surfaces to thicknesses of less than 0.5 mm each, and separated into two thin glass sheets. A single thick glass sheet, typically with a thickness of 0.5 mm or greater, may be patterned, covered with a protective layer over the pattern, thinned on its outside surface to a thickness of less than 0.5 mm, and the protective layer removed. This thinness of less than 0.5 mm may be accomplished using standard LCD equipment, despite the equipment having a sheet minimum thickness requirement of 0.5 mm.
US08673156B2 Suspension liquid extraction apparatus and method
The present invention relates to an apparatus for removing liquid from a suspension. More particularly, the present invention relates to a filtration apparatus using vacuum pressure, compressed air and radiant heat to facilitate extraction of water from a suspension and an air flow within the vacuum chamber to remove the evaporate as a cost-efficient and resource-efficient means of filtering and drying solids in large volumes of suspension to remove interstitial and chemically bound liquids, resulting in up to 100% total solids.
US08673155B2 Oil spill recovery method, vessel and apparatus
An oil spill recovery vessel (10) equipped with a skimmer unit (11) moves forward through an oil spill (6) at a normal skimming speed with its skimming unit operating to recover oil, and simultaneously transfers recovered oil through an oil transfer hose (17) to a bladder (19) being towed by the vessel using a towing cable (14). The oil transfer hose (17) and towing cable (14) attach to the vessel in substantially the same location situated approximately on the fore-aft centerline of the vessel and at least one third of the vessel's length from the stern or more forwardly an oil transfer bollard (15) of the vessel. In one embodiment the oil transfer hose (17) and towing cable (14) attach to an oil transfer bollard unit (15) comprising a towing post and an oil transfer pipe. The oil transfer bollard (15) can also be used to transfer oil from a towed unit to the vessel.
US08673153B2 Method and device for division of a biological sample by magnetic effect
A method for dividing an analyte present in a solution and that is fixed on magnetic particles, and devices to be used in the method and systems for implementing the method. The method includes sedimentation of the magnetic particles together with separation into a plurality of residues. One implementation: forms at least a residue of magnetic particles in a first receptacle; and displaces the at least the residues towards a plurality of second receptacles, preferably by relative translation of a magnetic system. The second receptacle is connected to the first receptacle through a fluid channel.
US08673152B2 Methods for polishing wastewater utilizing a bed of commingled bauxite residue and iron filings
Wastewater treatment systems, methods and apparatus for polishing a wastewater stream comprising a plurality of contaminants are provided. One system includes a vessel containing a plurality of natural media filtration agents selected to remove selected ones of the plurality of contaminants from the wastewater stream. In one embodiment, the vessel includes a bed of bauxite residue and at least one other natural media filtration agent. In another embodiment, the vessel includes a bed of compost and at least one other natural media filtration agent. The vessel includes a wastewater inlet that is in fluid communication with one or more of the natural media filtration agents. The vessel includes a wastewater outlet that is in fluid communication with one or more of the natural media filtration agents.
US08673151B2 Method of modifying surface of material
A method for surface modification of a material by means of introducing the phosphorylcholine group represented by the following formula (1-1) onto the surface of the material by treating a material having amino groups with a chemical compound containing an aldehyde derivative obtained by the oxidative ring-opening reaction of glycerophosphorylcholine. The method of the present invention provides various materials such as medical materials having superior biocompatibility and hydrophilicity.
US08673150B2 Method for reducing organic waste in waste water
A method of treating waste water is disclosed which comprises placing a porous container such as a mesh bag containing a gelatinous culture of vegetative bacteria into waste water. The gelatinous culture dissolves over time and releases the bacteria contained therein. In some embodiments, the porous container may be reclaimed at any time. Treatment with the method eliminates a substantial portion of organic waste found in waste water and reduces or eliminates the need for used to eliminate organic waste build up in waste water facilities.
US08673148B2 Multifiltration cartridge filtration apparatus
A filtration apparatus is provided comprising a housing having an inlet and an outlet and a plurality of spirally wound filtration cartridges. The filtration cartridges include two filter layers, a feed spacer layer and a permeate spacer layer. Seals are provided to prevent admixtures of feed and permeate and to permit recovery of permeate.
US08673147B2 Container for filtering liquid having an outlet aperture for air
A container for the filtration of liquid is described, which has a cup and a cover mounted on the cup. The cup is at least partly filled with a filter material and has at least one outlet window for the liquid. The cover has at least one inlet window and at least one outlet window for air, wherein at least the windows have lattice-like structures with lattice openings. The air outlet window has at least one recess extending inward from the plane of the window, which is provided at least partially with at least one lattice structure.
US08673140B2 Biological filtration system with socks of absorbent material
In an apparatus for treating wastewater, e.g sewage water, the water passes through absorbent material. The material comprises e.g inexpensive scraps or off-cuts of plastic foam. The pieces of material are contained by being stuffed into lengths of plastic mesh tubing, which are then formed into closed-ended socks. The socks are stacked in layers, and the water to be treated is trickled down through the layers. The socks can also advantageously be used for anaerobic and submerged treatment of wastewater.
US08673138B2 Fuel filter
A fuel filter includes a filter element disposed in a filter housing. The filter element is penetrated by fuel flowing in a radial direction from a raw end to a pure end. The fuel filter has a first water separator and a smooth-flow second water separator disposed in series with and connected to the first water separator. Fuel is discharged from the second water separator by a pressure difference generated in the fuel filter.
US08673137B2 Apparatus, system and method for detecting the presence of genuine serviceable product components
A process, system, and component configuration are described that discourages customer acceptance/use of will-fit, reconditioned, and counterfeit product components, by determining whether or not a serviceable product component is genuine. If a component is determined to not be genuine, then appropriate action may be taken to warn operators and document such findings. For example, one or more markers are disposed or otherwise put on the subject serviceable product component and serves as a targeted feature, and/or a particular characteristic of the filter itself is identified as the targeted feature. A sensor is used to detect the targeted feature and obtain information unique to the serviceable product component. The targeted feature(s) identifies the particular serviceable component as genuine and forms the basis for determining whether a genuine component has been installed. In some circumstances, a fluid filter product is the component that is the subject detection.
US08673131B2 Integrated sequence of methods for extracting and processing extra-heavy or bituminous crude oil with CO2 capture
The present invention relates to a method of preparing synthetic crude oil from a heavy crude reservoir, comprising: (a) extracting the heavy crude oil using a steam technology; (b) separating the crude extracted and the water; (c) separating the crude into at least one light cut and one heavy cut; (d) converting said heavy cut to a lighter product and a residue; (e) optionally, partially or totally hydroprocessing the converted product and/or the light cut(s) obtained upon separation (c); (f) burning and/or gasifying the conversion residue in the presence of metal oxides in at least one chemical looping cycle producing CO2-concentrated fumes in order to allow CO2 capture, the optionally hydroprocessed converted product and light separation cut(s) making up the synthetic crude oil, said combustion allowing to generate steam and/or electricity, and said gasification allowing to generate hydrogen, the steam and/or the electricity thus generated being used for extraction (a), and/or the electricity and/or the hydrogen thus generated being used for conversion (d) and/or hydroprocessing (e).
US08673127B2 Biosensor
In a biosensor for measuring a specific substance in a liquid sample, one or a combination of sugar alcohol, metallic salt, organic acid or organic acid salt which has at least one carboxyl group in a molecule, and organic acid or organic acid salt which has at least one carboxyl group and one amino group in a molecule, is included in a reagent layer provided on electrodes, thereby providing a highly-accurate biosensor which is excellent in stability and has high response (sensitivity, linearity) of the sensor to the substrate concentration.
US08673126B2 Dynamic precious metal assay device
A DYNAMIC PRECIOUS METAL ASSAY DEVICE is described which is based on the methodology of the parent patent DYNAMIC PRECIOUS METAL ASSAY METHOD, U.S. Pat. No. 4,799,999 and achieves a highly accurate gold assay with a range extended to over 24 karats. The specified device requires a manual expulsion of a small amount of electrolyte from a disposable cartridge into a miniature galvanic cell which is formed at the lower tip of the device pencil. Placing the said tip against a gold specimen under test, thereby wetting it, and then by initiating the charging cycle and interpolating algorithm in the external electronics results in a professionally accurate assay of the gold specimen under test. The superior performance of this device is attributed to the novel replaceable electrolytic cartridge and miniature galvanic cell which wets a specimen through a porous interface. This improved device is very stable, rugged and is easily maintained.
US08673125B2 Substrate conveyer and vacuum processing apparatus
An apparatus includes a chamber configured to form a reduced-pressure space, a carrier which holds a substrate, and a conveyer which conveys the carrier in the chamber. The chamber includes a side wall including an opening portion, and a partition wall arranged in the opening portion, the conveyer includes a permanent magnet provided on the carrier, and a driving magnet arranged outside the partition wall so as to drive the carrier, and the partition wall includes a first portion arranged between the driving magnet and a path through which the carrier passes, and a second portion arranged to connect the first portion to the side wall, the first portion having a smooth surface in a portion in which the first portion faces the path, and the first portion including a plurality of ribs arranged on a surface thereof on a side on which the driving magnet is arranged.
US08673122B2 Hot tile sputtering system
A system and method for sputtering a coating onto a glass substrate in a vacuum deposition chamber includes providing a backing plate with a separating element disposed at the backing plate. At least one target element or tile is disposed on a surface of the separating element, wherein an expansion gap is provided to allow for expansion of the target relative to the separating element during the sputtering process. The method includes sputtering material from the target and heating the target to a substantially elevated temperature during the sputtering process. The separating element may be a sheet having a low-coefficient of friction surface, and the target may be disposed on the low-coefficient of friction surface of the separating element. The separating element may thermally insulate the target from the backing plate, whereby the target may be heated to a substantially greater temperature than the backing plate during the sputtering process.
US08673121B2 Method of fabricating piezoelectric materials with opposite C-axis orientations
In accordance with a representative embodiment, a method, comprises: providing a substrate; forming a first piezoelectric layer having a compression-negative (CN) polarity over the substrate; and forming a second piezoelectric layer having a compression-positive (CP) over the substrate and adjacent to the first piezoelectric layer.
US08673120B2 Efficient boron nitride nanotube formation via combined laser-gas flow levitation
A process for producing boron nitride nanotubes and/or boron-carbon-nitrogen nanotubes of the general formula BxCyNz. The process utilizes a combination of laser light and nitrogen gas flow to support a boron ball target during heating of the boron ball target and production of a boron vapor plume which reacts with nitrogen or nitrogen and carbon to produce boron nitride nanotubes and/or boron-carbon-nitrogen nanotubes of the general formula BxCyNz.
US08673113B2 Process for reducing specific energy demand during refining of thermomechanical and chemi-thermomechanical pulp
A method for producing thermomechanical or chemi-thermomechanical pulp is provided. The process is characterized as having a reduced specific energy demand during refining. The process involves processing a pretreated wood material using one or more high consistency refining steps to produce a first pulp, optionally applying a chelating agent to the first pulp during HC refining to produce a stabilized pulp and treating the first or stabilized pulp with an alkaline-peroxide liquor to produce a treated pulp. The treated pulp is then processed by one or more second low consistency refining steps. Alternatively, the first pulp or stabilized pulp may be divided into a primary and secondary stream. The primary stream is treated with alkaline-peroxide liquor to produce a treated pulp. The secondary stream is processed using a secondary HC refining step to produce a partially refined pulp, and removing latency of the partially refined pulp and the treated pulp is removed in a common location. The treated pulp and the partially treated pulp is processed by one or more than one second low consistency refining step to produce a final pulp. The methods utilize less energy when compared with a method for producing pulp that requires both primary and secondary high consistency refining stages.
US08673112B2 Method and device for thermal hydrolysis and steam explosion of biomass
It is described a process for thermal hydrolysis and team explosion of biomass, said method comprising the steps of: (i) leading the biomass approximately continuous to a first preheating step and preheat the biomass, (ii) leading the preheated biomass into at least two reactors sequentially, (iii) heating and pressurising the reactor by addition of steam, (iv) keeping the reactor(s) at a certain temperature and pressure for a certain time, (v) leading the heated and pressurized biomass from the reactor(s) to a first pressure relief tank without any substantial pressure reduction and quickly relief the pressure of the biomass by means of a nozzle, in order to disintegrate the biomass, (vi) leading the biomass from the first pressure relief tank to a second pressure relief tank having a lower pressure than the pressure of the first pressure relief tank, (vii) leading the so treated biomass to a downstream facility for subsequent treatment. The invention also comprises a device for thermal treatment of biomass.
US08673109B2 Method of making a layered bituminous membrane, and an apparatus therefor
The invention relates to a method of making a grooved reinforced layered bituminous membrane (1) comprising the steps of: providing a web (A) of a reinforcing material, applying a layer (3) of a hot liquid adhesive, and applying a roller (10) having a surface pattern of grooves onto said layer (3) of an adhesive, to form a pattern of grooves (4) in the surface of said layer an adhesive.
US08673101B2 Fiber reinforced rebar with shaped sections
A composite reinforcing bar is formed by providing a reinforcing material supply of fiber strands ravings; a resin supply bath, and a puller for pulling the resin-impregnated reinforcing material through the resin bath. The material is wound on a helical holder, while the resin remains unset, rotated about its axis on a drive system so that the material is wrapped the holder which is indexed along it axis and removed when full for curing the resin on the holder while the body remains wrapped thereon. The bar is wrapped with the turns side by side and is then stretched out and held by longitudinal straight bars while the reinforcing structure so formed is embedded in a cast material.
US08673096B2 Method of fabricating pneumatic tire
A smooth resin film including an ultraviolet ray absorbing agent is pasted to an outer surface of a side portion of an unvulcanized tire, the unvulcanized tire is vulcanized and molded in a state of pasting the resin film, thereby, a pneumatic tire provided with the resin film at the outer surface of the tire side portion to be able to be exfoliated therefrom is fabricated.
US08673091B2 Pretreatment compositions and methods for coating a metal substrate
Disclosed are methods for treating metal substrates, including ferrous substrates, such as cold rolled steel and electrogalvanized steel. The methods include contacting the substrate with a pretreatment composition that includes: (a) a group IIIB and/or IVB metal; (b) free fluorine; (c) a metal fluoride salt formed from a metal which forms a fluoride salt having a pKsp of at least 11; and (d) water.
US08673090B2 Dishwasher
A water flow control device for an appliance includes a sump to collect water from a washtub, a supply passage to supply water from the sump to the washtub, a drain passage, coupled to the sump to discharge water; and a disposer to dispose contaminates in water from the sump. The disposer is in fluid communication with the drain passage but not the supply passage.
US08673088B1 Foam dispensing device
A device for combining multiple components into a foam mixture and dispensing the foam mixture into a pipe is described. The multiple components are combined immediately prior to dispensing, which maximizes activity for labile, biologically active components whose degradation accelerates upon combining components. Embodiments of the device are relatively light weight and adapted to removably couple to sewer cleaning vehicles.
US08673087B2 Reducing copper defects during a wet chemical cleaning of exposed copper surfaces in a metallization layer of a semiconductor device
A method for treating a semiconductor device includes dissolving an inert gas species in a wet chemical cleaning solution and treating a material layer of a semiconductor device with the wet chemical cleaning solution in ambient atmosphere. The inert gas species is oversaturated in the wet chemical cleaning solution in the ambient atmosphere.
US08673086B2 Method and device for cleaning a substrate and storage medium
In a cleaning method, a substrate having a pattern formed on the surface thereof can be cleaned by using a cleaning fluid, while preventing the pattern protrusions from being flattened when the cleaning fluid is removed or dried. The cleaning method includes the steps of: loading a substrate onto a loading platform inside a processing chamber; heating the substrate; and supplying a cleaning fluid onto the surface of the substrate. The substrate is heated in the substrate heating step so that the Leidenfrost phenomenon occurs and steam of the cleaning fluid is interposed between the substrate and droplets of the cleaning fluid supplied to the substrate in the cleaning fluid supply step.
US08673079B2 Film deposition apparatus and substrate processing apparatus
A film deposition apparatus includes: a turntable; a first reaction gas supply part and a second reaction gas supply part extending from a circumferential edge toward a rotation center of the turntable; and a first separation gas supply part provided between the first and second reaction gas supply parts. A first space contains the first reaction gas supply part and has a first height. A second space contains the second reaction gas supply part and has a second height. A third space contains a first separation gas supply part and has a height lower than the first and second heights. A motor provided under the rotation center of the turntable rotates the turntable. A rotation shaft of the turntable and a drive shaft of the motor are coupled without generation of slip.
US08673077B2 Vapor deposition device, vapor deposition method, and organic EL display device
Vapor deposition particles (91) discharged from at least one vapor deposition source opening (61) pass through a plurality of limiting openings (82) of a limiting unit (80) and a plurality of mask openings (71) of a vapor deposition mask (70), and adhere to a substrate (10) that relatively moves along a second direction (10a) so as to form a coating film. The limiting unit includes a plurality of plate members stacked on one another. Accordingly, it is possible to efficiently form a vapor deposition coating film in which edge blurring is suppressed on a large-sized substrate at a low cost.
US08673073B2 Methods for purifying metallurgical silicon
A method for purifying silicon bearing materials for photovoltaic applications includes providing metallurgical silicon into a crucible apparatus. The metallurgical silicon is subjected to at least a thermal process to cause the metallurgical silicon to change in state from a first state to a second state, the second stage being a molten state not exceeding 1500 Degrees Celsius. At least a first portion of impurities is caused to be removed from the metallurgical silicon in the molten state. The molten metallurgical silicon is cooled from a lower region to an upper region to cause the lower region to solidify while a second portion of impurities segregate and accumulate in a liquid state region. The liquid state region is solidified to form a resulting silicon structure having a purified region and an impurity region. The purified region is characterized by a purity of greater than 99.9999%.
US08673071B2 Joint compound using predispersed dedusting agents
This method relates to making a joint compound that includes predispersing a dedusting agent in water to make a predispersed dedusting agent. Dry components, including at least one filler, are combined to make a dry mixture. Process water is pumped into a vessel and the predispersed dedusting agent is introduced to the vessel. The dry mixture is then added to the vessel and all components are blended to make a homogeneous product.
US08673070B2 Process for producing silicon oxide thin film or silicon oxynitride compound thin film and thin film obtained by the process
Disclosed is a process for producing a silicon oxide or silicon oxynitride thin film having a high level of water vapor and oxygen barrier property and a high strength with a higher efficiency by a solution process which is advantageous in productivity. Also disclosed is a thin film that is obtained by the process and is useful, for example, as a protective film for electric elements such as organic EL elements. A solution containing a smectite group silicate layered compound and a silazane compound is coated onto a surface of a substrate by a liquid phase process to form a film. The thin film thus obtained is exposed to ultraviolet light under an oxygen atmosphere to produce a silicon oxide thin film or a silicon oxynitride compound thin film containing the smectite group silicate layered compound. The smectite group silicate compound is a material represented by the following general formula. A1/3BmSi4O10.nH2O  [Chemical Formula 1]
US08673065B2 Sintered fiber filter
Sintered fiber filters are provided that can afford high particle capture efficiency and/or low pressure drop during operation, and are useful in applications such as semiconductor processing. The shape of at least a portion of the individual fibers (e.g., metal fibers) used to make the filter have a three-dimensional aspect, which allows for a low packing density and high porosity filtration media. Certain filters have a cylindrical or tube-like shape with tapered ends of higher density. Methods of making such filters, for example, using axial pressing, are also described.
US08673059B2 Rapid temperature swing adsorption contactors for gas separation
Novel adsorbent contactors and methods are disclosed herein for use in temperature swing adsorption for gas separation applications, as well as for heat exchange applications.
US08673057B2 Zeolite DDR membranes
DDR nanocrystals of uniform size and structure were synthesized using hydrothermal secondary growth and then used to make DDR zeolite membranes and for any other use where uniform, small DDR zeolite crystals are beneficial.
US08673056B2 Process and apparatus for the purification of methane rich gas streams
The invention is directed to processes and apparatuses for gas treatment, in particular for the purification of methane rich gas streams, such as gas obtained from the conversion from organic matter (“biogas”). In accordance with the present invention there is provided an apparatus and a process for producing a purified methane comprising gas stream (P) from a methane containing gas stream (A), comprising the steps of: (a) pressurising said methane containing gas stream (A) and subsequently cooling it, whereby a stream comprising condensed contaminants (C) and a methane comprising stream (B) are obtained; (b) optionally feeding said methane comprising stream (B) to an adsorption unit and/or a catalytic conversion unit, whereby the concentration of contaminants in stream (B) is further decreased; and (c) cooling the methane comprising stream (B) to a temperature which is sufficient to condensate CO2 from said stream (B), whereby said purified methane comprising gas stream (P) is obtained.
US08673055B2 Improving the recovery of precious metals from recalcitrant refractory ore
The invention provides a novel process for improving the recovery of precious metals from recalcitrant refractory ores by the use of hydrofluoric acid dissolved in ionic liquids. The solution of hydrogen fluoride gas in an ionic liquid is contacted with dry crushed ore at a temperature and for a period of time commensurate with the fracturing of a specific recalcitrant refractory ore. The excess ionic liquid is separated from the ore and the fractured ore is further treated with dilute sodium cyanide solution to extract precious metals in greater yields.
US08673053B2 Method of hardening an interface of carbon material using nano silicon carbide coating
Disclosed is a method for hardening an interface of a carbon material by using nano silicon carbide coating. A carbon material-aluminum composite prepared by the disclosed method is light in weight, and has a high dynamic strength, and thus can be applied to currently used cars and aluminum wheels. Furthermore, the composite can be utilized as a material for aircrafts, spacecraft, ships, etc. requiring a high strength.
US08673049B2 Low-temperature sintered silver nanoparticle composition and electronic articles formed using the same
A silver nanoparticle composition is provided which is possible to be sintered through sintering at a low temperature in a short time and to form silver electro conductive film and wiring which is favorable for adhesion to a substrate and low in resistance, and articles using the same are provided. The silver nanoparticle composition is provided, wherein a main component of a solvent is water, a pH of the composition is within a range of 5.3 to 8.0, a silver nanoparticle included in the composition is protected by an organic acid or a derivative thereof, and the content of the organic acid or the derivative thereof with respect to silver is 2 to 20% by mass.
US08673047B2 Process for producing foamed slag
A process and material for producing foamed slag by which the foaming of a slag with a high chromium oxide content can be achieved. An electric arc furnace is charged with a mixture of metal oxides and carbon and, below the slag at the metal-slag interface, the metal oxide is reduced by carbon and limestone and becomes thermally discordant. The occurring gases cause the slag to foam due to the formation of bubbles.
US08673046B1 Process for removing and recovering phosphorus from animal waste
A process for removing phosphorus from solid poultry or animal wastes involving (a) mixing solid poultry or animal wastes with water and acid at a pH lower that about 5.0 and higher than about 3.0 to form (i) a liquid extract that contains suspended solids of about 3.5 g/L and soluble phosphorus and (ii) a washed solid residue (having a N:P ratio of at least more than 4 expressed on an elemental basis), (b) separating the liquid extract from the washed solid residue to form separated liquid extract and separated washed solid residue, (c) mixing the separated liquid extract with an alkaline earth base to a pH of about 8.0 to about 11.0, (d) mixing the liquid extract with a flocculant to form (i) precipitated phosphorus solids with P2O5 content greater than about 10% and (ii) a liquid, and (e) separating the precipitated phosphorus solids from the liquid to form separated phosphorus solids and separated liquid. The process is conducted at a temperature greater than about 5° C. and less than about 50° C. The solid poultry or animal wastes are not pretreated prior to mixing the solid poultry or animal wastes with water and acid; such pretreatments include those that may cause the complete or partial loss of oxidizable organic carbon and nitrogen.
US08673044B2 Process for producing aluminum titanate-based ceramics body
The invention is to provide a process for producing an aluminum titanate-based ceramics body, wherein, as a regenerated starting material, a fired body recovered in a production process for an aluminum titanate-based ceramics body is used and the aluminum titanate-based ceramics body excellent in a mechanical strength and in a thermal characteristics such as low thermal expansion and heat resistance can be obtained. The invention provides a process for producing an aluminum titanate-based ceramics body using a fired ceramics body recovered in a production process for an aluminum titanate-based ceramics body, comprising the following steps: a step of preparing a pulverized product having a median particle diameter of 100 μm or less from the fired ceramics body; a step of preparing a regenerated clay containing the pulverized product and water; a step of shaping the regenerated clay to form a shaped body; and a step of firing the shaped body.
US08673043B2 Fluid filter
A straight through flow filter element is provided in which the seal and/or seal support may be arranged to be generally flush with the flow face of the filter media pack. In some embodiments, long filter media packs may be facilitated. Additionally, certain processing advantages in simplicity of molding a seal on the support can be accomplished.
US08673042B2 Filter element and filter device
A filter element may include an annular filter body and an internal support frame. The filter body may be supported radially on the inside of the internal support frame. At least one end disk may be disposed at the filter body and the internal support frame. The end disk may have a central disk opening and a radial seal arranged coaxially to the disk opening. The internal support frame may have a plurality of radial centering elements distributed in the circumferential direction. The frame may be projected inwardly and extends to a radial end on the inside at an inner wall of the end disk. The inner wall may enclose the disk opening.
US08673041B2 Filter holding frame with adjustable clamping mechanism and slot for pre-filter
Embodiments of the invention generally provide a filter frame assembly adapted for clamping in a housing is provided. The frame assembly includes a frame having a downstream frame member coupled to a cross-member, the downstream frame member and cross-member adapted to fit within the housing. At least two clamp mechanisms are coupled to frame assembly. Each of the clamp mechanisms include a rotatable rod coupled to a handle which is used to displace the frame assembly. The handle is configured to be clear of a filter receiving aperture defined above the cross-member when the handle is in both of an open or a closed position.
US08673040B2 Filter construction for use with air in-take for gas turbine and methods
The filter of the invention is a cartridge filter comprising a structure that can maintain a filter medium in an air stream to filter particulates to protect a gas turbine power system. The filter combines a mechanically adequate filter structure and an effective filter medium for to obtain a useful system.
US08673036B2 Quench chamber assembly for a gasifier
A gasifier includes a combustion chamber in which a fuel is burned to produce a syngas and a particulated solid residue. A quench chamber having a liquid coolant is disposed downstream of the combustion chamber. A dip tube couples the combustion chamber to the quench chamber. The syngas is directed from the combustion chamber to the quench chamber via the dip tube to contact the liquid coolant and produce a cooled syngas. A draft tube surrounds the dip tube such that an annular passage is formed between the draft tube and the dip tube. An asymmetric or symmetric faceted baffle is disposed proximate to an exit path of the quench chamber. The cooled syngas is directed through the annular passage and impacted against the baffle so as to remove entrained liquid content from the cooled syngas before the cooled syngas is directed through the exit path.
US08673035B2 Solar-thermal reaction processing
In an embodiment, a method of conducting a high temperature chemical reaction that produces hydrogen or synthesis gas is described. The high temperature chemical reaction is conducted in a reactor having at least two reactor shells, including an inner shell and an outer shell. Heat absorbing particles are included in a gas stream flowing in the inner shell. The reactor is heated at least in part by a source of concentrated sunlight. The inner shell is heated by the concentrated sunlight. The inner shell re-radiates from the inner wall and heats the heat absorbing particles in the gas stream flowing through the inner shell, and heat transfers from the heat absorbing particles to the first gas stream, thereby heating the reactants in the gas stream to a sufficiently high temperature so that the first gas stream undergoes the desired reaction(s), thereby producing hydrogen or synthesis gas in the gas stream.
US08673033B2 Display control circuit and projector apparatus
A display control circuit includes a device driving unit that alternately writes a left video image and a right video image in a time-division manner to a light modulating device, a light source driving unit that increases or reduces the brightness of a light source that emits light passing through the light modulating device, a shutter eyeglass driving unit that provides shutter eyeglasses with a shutter driving signal, and a control unit that instructs the light source driving unit to reduce the brightness of the light source in the duration of a switchover between the left video image and the right video image for the light modulating device or instructs the light source driving unit to increase the brightness of the light source in the duration in which the left video image or the right video image is written solely to the light modulating device.
US08673032B2 Method of manufacturing coke from low grade coal
The present invention provides methods of transforming low rank coals into high quality metallurgical coke, and the coke products produced by such methods.
US08673030B2 Methods of producing water-resistant solid fuels
The invention provides a method by which high moisture low rank coal or other carbonaceous material may be transformed into a high-energy, water resistant product. The raw feed is comminuted then mechanically compacted by a roller press with rolls of a specified profile to mobilize the inherent moisture and collapse most of the interstitial pore space. The mobilized moisture is then removed by low-temperature drying and the material is sized and shaped to form a product that is resistant to re-absorption of water or other liquids. The present invention will promote the use of low rank coal for liquefaction and gasification.
US08673025B1 Wet electrolytic capacitor and method for fabricating of improved electrolytic capacitor cathode
A process for making a valve metal material useful for forming electrolytic devices comprising the steps of: establishing multiple tantalum or niobium components in a billet of a ductile material; working the billet to a series of reduction steps to form said tantalum or niobium components into elongated elements; cutting the resulting elongated elements and leaching the ductile metal from the elements; washing and mixing the cut elements; and forming the cut elements into a sheet. The resulting sheet may be formed into anodes and cathodes and assembled to form a wet electrolytic capacitor.
US08673023B2 Method for preparing a coloring composition
A method for manufacturing a coloring agent for keratin fibers from a first composition A and a second composition B is provided. The method comprises directing the first composition A from a container A by a filler apparatus through an inlet opening into a second container B containing the second composition B. In container B, as a result of the introduction of composition A and/or the action of the filler apparatus, at least one exit opening is formed out of which the coloring agent for keratin fibers exits from container B as a mixture of compositions A and B.
US08673021B2 Arthroscopic tissue scaffold delivery device
A small diameter delivery device capable of delivering a tissue loaded scaffold arthroscopically to a tissue defect or injury site without reducing the pressure at the injury site is provided. The scaffold delivery device of the present invention comprises a plunger system that includes two main components: an insertion tube and an insertion rod. The insertion tube has a flared proximal end for holding a tissue scaffold prior to delivery. An elongate, hollow body extends from the flared proximal end to a distal end of the insertion tube, and defines a passageway that extends through the body for delivery of the tissue scaffold. The insertion rod has an elongate body that extends into a handle at a proximal end and a tip at a distal end. The insertion rod is configured to be removably disposed within the insertion tube for sliding along the passageway to effect delivery of the tissue scaffold through the insertion tube.
US08673015B2 Concave resurfacing prosthesis
A glenoid component for use with a prosthetic humeral component for use in performing shoulder arthroplasty is provided. The glenoid component may be fitted at least partially into a cavity formed in the glenoid vault. The glenoid component includes a body having a stem portion for inserting at least partially into the cavity formed in the glenoid vault. The stem portion cooperates with the interior wall of the cavity formed in the glenoid vault. The body has a bearing portion for articulating cooperation with the prosthetic humeral component.
US08673014B2 Method of cranial repair and cranial repair implant molding device
A method of cranial repair and the cranial implant molding device used therein, the device having a frame or base that receives a bottom or convex molding plate and a top or concave molding plate in a manner whereby the two plates are separated a distance to receive a settable or curable implant forming material therebetween. The plates are separated by a compressible member such that by the use of threaded mechanical fasteners or similar members the distance between the two plates can be adjusted by tightening or loosening the mechanical members. The thickness of the implant is varied by varying the separation distance on different sides of the frame.
US08673007B2 Implant with insertion device and method
Embodiments of the invention include expandable medical implant systems and methods. The systems may include devices to reinforce a tube through which a fill material may be moved at least in part into expandable medical implants. In some embodiments, an implant replaces one or more of vertebral bodies, portions of vertebral bodies, discs, and portions of discs of the spine.
US08672995B2 Polymer prosthesis
A polymer prosthesis with lumen and an axial length and having in a pre-delivery condition a plurality of relatively stiff stenting segments spaced from each other along the length of the prosthesis, the spaces between the relatively stiff stenting segments of a first polymer being bridged by relatively flexible linking segments of a second polymer, different from the first, the relatively stiff stenting segments and the relatively flexible linking segments being alternately arranged along the length of the prosthesis.
US08672993B2 Pararenal stent graft
A stent graft for endovascular introduction into the pararenal region of the descending aorta. The stent graft has an elongate tubular body (10) with a proximal portion (12), a distal portion (16) of a diameter less than the proximal portion and a tapered central portion (14). A notional transverse clock face on the tubular body has 12 o'clock at a notional anterior longitudinal datum line. The stent graft has a scalloped cut out (26) centered at about 12:30 o'clock and a fenestration (28) at about 12:00 o'clock in the proximal portion and first and second fenestration assemblies which can be low profile side arms at about 2:15 o'clock and about 10:00 o'clock in the tapered central portion. The tapered central portion can have an arcuate side wall (30) so that the tapered portion has an outer face which is concave.
US08672992B2 Stent and stent-graft having one or more conformance struts
A stent includes a main body having proximal and distal ends, and at least one conformance strut coupled to the proximal end of the main body. A portion of the at least one conformance strut extends proximal to a proximal end of a graft material in a compressed delivery configuration, and further is aligned inside the proximal end of the graft material in an expanded deployed configuration. In the deployed configuration, the proximal conformance strut may at least partially encircle the graft material just distal to the proximal end of the graft material, which may reduce the likelihood of infolding at the proximal edge of the graft material and potential endoleaks.
US08672987B2 Handpiece with optical unit of a skin phototreatment device
Handpiece formed of a shell with a handgrip connected to a bundle of electrical power supply cables and of heat transfer fluid tubes and a head, accommodating a cartridge fitted with the controlled light source and with a light guide fed from the light source and the outlet surface of which constitutes the surface via which the light signal is emitted towards the surface of the skin that is to be treated. It comprises a housing, made in the shell, arriving under the emission surface of the cartridge and equipped with guide means and clip-fastening members. An interchangeable optical unit carrying the light guide is fitted removably into the housing. This optical unit has a casing accepting the light guide and equipped with guiding and clip-fastening surfaces to collaborate with the guide means and the retractable clip-fastening members belonging to the housing.
US08672985B2 Bone fasteners and method for stabilizing vertebral bone facets using the bone fasteners
A bone fastener for stabilizing bone fragments includes a single or multiple components coupleable with one another and displaceable to a locked position of the bone fastener.
US08672984B2 Method and apparatus for retaining screw in a plate
A retention system for maintaining a screw to a vertebral plate is described herein. One or more screws extend through apertures within the vertebral plate. A cavity is positioned adjacent to and overlaps into the aperture. A ring is positioned within the cavity and held in position by a cap. The cap attaches to the plate to prevent removal of the ring. The ring is deflectable between a first shape to allow the screw to be inserted and removed from the aperture, and a second shape to prevent screw back-out from the aperture.
US08672982B2 Apparatus and methods for repairing craniomaxillofacial bones using customized bone plates
Bone plates and methods of using the bone plates for adjoining bone fragments are disclosed herein. A device for adjoining at least two bone fragments includes a delivery catheter having an elongated shaft with a proximal end, a distal end, and a longitudinal axis therebetween, wherein the delivery catheter has an inner void for passage of at least one filling material and an inner lumen for passage of a light source; a conformable bone plate releasably engaging the distal end of the delivery catheter, wherein the conformable bone plate has a first surface, a second surface, a proximal end, and a distal end and at least one aperture extending from the first surface to the second surface for receiving a fastener; and an adapter releasably engaging the proximal end of the delivery catheter for receiving the light source and a delivery system housing the at least one filling material.
US08672981B2 Osteosynthesis plate comprising through-openings which are inclined in relation to the plane of the plate
An osteosynthesis plate is described, which is suitable for treating jaw fractures. The osteosynthesis plate has a plane of the plate as well as two plate sections 12, 14 with associated longitudinal axes 16, 18 extending substantially within the plane of the plate and inclined or staggered with respect to one another. Through openings 20, 22 inclined to the plane of the plate are formed in each of the two plate sections 12, 14. The angular alignments of the through openings 20, 22 within the plane of the plate differ with respect to a longitudinal axis 16 serving as reference line from one another by less than approximately 60°. In applications in the jaw region this slight deviation of the angular alignments permits an intraoral securement of the osteosynthesis plate. A transbuccal access through the cheek can thus be dispensed with.
US08672972B2 Low profile vertebral stabilzation systems and methods
Skeletal stabilization systems include a base, a longitudinal member, and a retaining member. The base includes an engagement surface with a surface area that is positionable in contact with a bone to atraumatically or traumatically engage the base to the bone. The retaining member engages the base to retain the longitudinal member relative to the base so that the longitudinal member can provide a desired stabilization effect to one or more adjacent bony portions.
US08672971B2 Chiropractic table apparatus and method of use
A chiropractic table has a base, a table support member connected to the base and extending upward from the base, an axial-lateral-tilt mechanism laterally connected to table support member, a cephalad section connected transversely to and being supported by the table support member above the base, a head section connected to and extending longitudinally from a first cephalad section end of the cephalad section, and a caudal section interconnected with the axial-lateral-tilt mechanism and the table support member and being positioned longitudinally adjacent a second cephalad section end of the cephalad section where the axial-lateral-tilt mechanism has an axial pivot mechanism configured to axially swing the caudal section along a predefined arc, the arc coinciding with a predefined radial distance from a pivot axis that is parallel to a longitudinal axis of the chiropractic table and located a predefined distance above a top surface of the chiropractic table.
US08672969B2 Fracture fixation device
Assemblies for securing fractured bone are provided. The assembly includes a first fixation element, a second fixation element, and an adjustable flexible member construct. The first fixation element having a male or a female sleeve is secured within a first portion of the fractured bone. The second fixation element having the other of the male or female sleeve telescopically received within the one of the male or female sleeve is secured within a second portion of the fractured bone. The adjustable flexible member construct extends between the first and second fixation elements and has at least one adjustable loop coupled to the first fixation element and the second fixation element and a pair of adjusting ends extending through an opening in the first fixation element. The pair of adjusting ends can be pulled to reduce a diameter of the adjustable loop and to compress fragments of the fractured bone.
US08672966B2 High-strength suture
A surgical suture is made of an elongate, hollow braid of high strength fibers. The braid defines an elongate, longitudinally-extending, central chamber that is open and without any core material extending therein so that, when a surgeon's knot is tied with the suture, the cross-sectional shape of the braid collapses upon itself and is reduced in size in response to pressures experienced when the knot is tightened thereby producing a low profile knot that resists slippage. Preferably, the braid is of a size corresponding to a USP size 5-0 to USP size 7 suture and has one or more, preferably a pair, of color contrasting monofilaments woven therein to enhance suture visibility. Methods of making a flattened suture and of utilizing the high strength suture to maintain body tissues in an engaged position to promote healing are also provided.
US08672965B2 Nucleus replacement based on injectable PVA gels
The invention relates to novel polyvinyl alcohol (PVA) gels which gelate in situ and are suitable for nucleus (gel bodies of the intervertebral disks) replacement, and to a process and to an apparatus for administration thereof, to the use thereof and to a vessel which comprises an inventive PVA gel.
US08672964B2 Puncture seals for closing hollow organs having a puncture opening
A puncture seal that seals a hollow organ having a puncture opening in a wall includes an inner bearing element that bears on an intraluminal side of the wall of the hollow organ, and a connection element connected to the inner bearing element and which, when the seal is fitted on the wall, protrudes through the puncture opening, wherein the inner bearing element has a surface area greater than the puncture opening, the inner bearing element is a continuous strip extending in an arc shape and strip sections lie substantially flat alongside one another in a fitted state, and the strip sections have a width that is smaller than the greatest length of the puncture opening, and the inner bearing element along the strip can be inserted into the hollow organ through the puncture opening and substantially parallel to the wall of the hollow organ.
US08672960B2 Method and apparatus for endoscopic ligament release
The invention pertains to a method, apparatus, and system for cutting anatomic members, such as ligaments, in surgical procedures such as carpal tunnel release, plantar fasciotomy, gastroc release, cubital tunnel release, and tarsal tunnel release. The apparatus includes a retrograde knife and a guide tool for guiding the knife and a scope during surgery. Relevant features include a knife stop for preventing the knife from inadvertently raising out of the knife channel, indicators showing the proper orientation for the guide tool, a self dilating tip and channel design on the guide tool, a cover piece and/or pivotable panel system for preventing ligaments and other anatomy from getting caught in the guide tool, a pivot pin and groove system for stabilizing the knife and also assuring that the knife blade is not inadvertently raised out of the channel, and a use indicator for preventing re-use of a single use device.
US08672958B2 Gastric bypass devices and procedures
Methods and devices for treating obesity are provided, and more particularly, methods and devices for performing gastric bypasses are disclosed. In one exemplary embodiment a gastric bypass procedure is provided that includes forming a gastro-entero anastomosis between a stomach and an intestine and forming an entero-entero anastomosis between a portion of the intestine distal to the gastro-entero anastomosis and a portion of the intestine proximal to the gastro-entero anastomosis. A surrogate path is formed between the esophagus and the gastro-entero anastomosis to at least partially direct fluid from the esophagus to the intestine by way of the gastro-entero anastomosis, thereby bypassing the stomach. Still further, methods for repairing an abdominal aortic aneurysm and leaking heart valve are also disclosed.
US08672956B2 Endoscopic suturing machine
An endoscopic suturing machine, having a housing with a housing upper part for receiving drives for the stitch-forming tools, a housing shaft adjoining the housing upper part for a receiving device for transmitting the motions generated by the drives to the stitch-forming tools, which have at least one needle bar guided in the housing shaft with a thread-carrying needle and a shuttle cooperating with same for forming stitches. The shuttle is received by a shuttle bar. The needle bar (5) is designed as a hollow body for receiving and guiding the thread. The thread guide elements are arranged between the thread spool 31 receiving the thread reserve and the needle bar (5) and are arranged in relation to the needle bar (5) such that the thread runs essentially in a straight line between the exit from the mounting device (17) and the entry into the needle bar (5).
US08672952B2 Close-wound coil and medical treatment tool using this coil
A medical treatment tool is provided having: a force transmission member having a distal end and a proximal end; an end effector which is provided on the distal end of the force transmission member in a non-rotatable manner with respect to the force transmission member; a control wire which is inserted into the force transmission member; and a rotatable coupling which is provided between the end effector and the control wire, and is coupled rotatably to the end effector with respect to the control wire.
US08672948B2 Vertebral spacer size indicator
A disposable measuring device for use in measuring the width, height and depth of an intradiscal space is provided, the device including an elongated body having an upper surface, a lower surface, a proximal end and a distal end. The elongated body also has a first pair of members configured for receiving a first cursor slidably arranged for measuring a width dimension, a second pair of members configured for receiving a second cursor slidably arranged for measuring a height dimension; and a detachable stop operatively connected to the first pair of members and the second pair of members, the detachable stop insertable into at least one opening located at the proximal end of the elongated body, the detachable stop configured for measuring a depth dimension.
US08672945B2 Device for positioning a bone cutting guide
A device for positioning a cutting guide with respect to a bone comprising a body forming the cutting guide or intended to be fixed to the cutting guide; a least two contact members intended to freely contact the bone; and adjustment means for individually varying the relative position of the body with respect to each contact member.
US08672942B2 Integrated system for cleaning bone and milling the cleaned bone to form bone chips
A system for cleaning bone that includes a base unit with a motor, a cleaning head (56) with a brush (58) and mill head with a mill element. Both the cleaning head and the mill head are designed to be coupled to the base unit. Both the brush and mill element have features that facilitate their coupling to the motor. When the cleaning head is attached to the base unit, a motor in the base unit rotates the brush to clean the bone. When the mill head is attached to the vase unit, the base unit motor actuates the mill element to convert the cleaned bone into bone chips.
US08672941B2 Coring device for preserving living tissue
Improved coring devices suitable for articular cartilage and bone, wherein the cutting device is capable of slicing through a tough protective tangential zone, delicately separating the shock absorbing columns of cells in the radial zone of the cartilage, and finally cutting into the hard underlying bone in a manner that preserves the viability of osteochondral cells. The coring device features an annulus having a flat annular cutting edge interrupted by at least one serration having neutral cutting angles. A method for concurrently removing cartilaginous and bony tissue using an improved coring device that preserves the viability of osteochondral cells.
US08672937B2 Cool-tip thermocouple including two-piece hub
A surgical device for performing a surgical procedure on a patient is provided and includes a handle assembly including a housing having a distal end and a proximal end; a tissue engaging member supported in and extending from the distal end of the housing of the handle assembly; at least one conduit having a first end operatively associated with the tissue engaging member and a second end extending from the housing of the handle assembly; and a strain relief member supported on the at least one conduit and connected to the housing, wherein the strain relief member and the housing are configured to enable poly-axial movement of the strain relief member with respect to the housing.
US08672935B2 Ultrasound treatment system
An ultrasound treatment system comprises an ultrasonic transducer, a handpiece, a probe, a sheath, a clamping member, an operation unit, an operating member, a suction base, and a perfusion base. The ultrasonic transducer generates ultrasonic vibrations. The handpiece has the ultrasonic transducer incorporated therein. The probe is connected to the ultrasonic transducer for transmitting ultrasonic vibrations to a distal member realizing a stationary portion that is a treatment portion for treating a living tissue. The sheath serves as a protecting member for shielding the probe. The clamping member is opposed to the distal member at the distal end of the sheath for clamping a living tissue in cooperation with the distal member. The operation unit is manipulated for clamping a living tissue with the clamping member and distal member or freeing the living tissue therefrom.
US08672933B2 Microwave antenna having a reactively-loaded loop configuration
A microwave ablation system is provided. The microwave ablation system includes a power source. A microwave antenna is adapted to connect to the power source via a coaxial cable feed including an inner conductor defining a portion of a radiating section of the microwave antenna, an outer conductor and dielectric shielding. The inner conductor loops back around and toward the outer conductor of the coaxial cable feed such that a distal end of the inner conductor is operably disposed adjacent the dielectric shielding. The inner conductor includes one or more reactive components disposed thereon forming a reactively-loaded loop configuration configured to maximize delivery of microwave energy from the power source to tissue such that a desired effect to tissue is achieved.
US08672932B2 Center fed dipole for use with tissue ablation systems, devices and methods
The present invention relates to systems and devices for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In particular, the present invention relates to systems and devices for the delivery of energy employing a center fed dipole component. In certain embodiments, methods are provided for treating a tissue region (e.g., a tumor) through application of energy with the systems and devices of the present invention.
US08672930B2 Endoluminal ablation cryoballoon and method
A method of ablating tissue is provided, including positioning an expandable element of a catheter in a blood vessel; inflating the expandable element with a volume of refrigerant to substantially occlude the blood vessel; measuring the volume of refrigerant used to inflate the expandable element; correlating the measured volume to an inflated dimension of the expandable element; defining at least one of a target pressure within the expandable element and a target flow rate for refrigerant delivery to the expandable element based at least in part on the inflated dimension; regulating refrigerant delivery to the expandable element to attain the at least one defined target pressure within the expandable element or defined target flow rate for fluid delivery to the expandable element; and ablating at least a portion of the blood vessel with the expandable element.
US08672929B2 Laser probe tip
A probe tip for communicating and laterally directing electromagnetic radiation comprises a waveguide, a primary capsule, a compressible member and a malleable secondary capsule. The waveguide is configured to communicate electromagnetic radiation and includes a beveled surface at a distal tip for redirecting electromagnetic radiation in a lateral direction. The primary capsule is attached over the distal tip of the waveguide. The compressible member covers a portion of the primary capsule. The malleable secondary capsule is positioned over the primary capsule and the compressible member, and includes a crimp that compresses the compressible member against the primary capsule and secures the secondary capsule to the primary capsule.
US08672927B2 Laser applicator
A laser applicator includes an optical fiber with a core surrounded by a cladding. The cladding contains openings (40) for coupling radiative energy outward. To accomplish an even distribution of energy, the size of the opening increases from the proximal end to the distal end. The openings (40) are combined into groups (45), with the number of openings within a group varying. The openings (40) are of a uniform size so that the area of decoupling (13) can be produced in a simple manner.
US08672925B2 Device, method, and control program for refractive surgery
An apparatus and a method for refractive surgery, in particular LASIK, make provision whereby the apex of the cornea is taken as a basis, as the ablation center, for the refractive procedure. For this purpose, the dependence of the position of the apex on properties of the pupil is determined in the case of the eye to be treated and, from this dependence, measured properties of the pupil are used to calculate the position of the ablation center during the refractive surgery.
US08672920B2 Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites
Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessel lumens. A penetrating catheter is inserted into a blood vessel lumen and a penetrator is advanced from the catheter in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the delivery catheter may remain in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member may be advanced into a vein or venule and used to occlude the lumen of the vein or venule during and after injection of a substance such that the substance will not be carried away by normal venous blood flow.
US08672916B2 Absorbent garment having outer shell and adjustable absorbent assembly therein
An absorbent garment having a garment-like outer shell and an absorbent assembly adapted for adjustable positioning therein is disclosed. In particular embodiments, the absorbent garment includes garment shell, at least one inner attachment member, and an absorbent assembly. The inner attachment member can be disposed at a waist region of the garment shell. The absorbent assembly can include a fastening component disposed at an end region, the first fastening component adapted for refastenable engagement to the inner attachment member. The inner attachment member can be configured such that a user may adjust a position of the refastenable engagement to the inner attachment member.
US08672915B2 Wearing article
A wearing article having front and rear waist belt members that include waist elastic members attached thereto and spaced one from another in a longitudinal direction Y. On non-contractile regions, these elastic members do not overlap graphics on respective heat-sealable sheets or exert contractile force thereon. The non-contractile regions are formed by leaving between inner and outer sheets as well as between inner and outer sheets not coated with adhesive in respective middles of the front and rear waist belt members as viewed in a transverse direction X and cutting the waist elastic members attached under tension in the respective middles of the waist belt members. Along the ends of the non-contractile regions on the side of the crotch member, the inner and outer sheets as well as the inner and outer sheets are respectively joined to each other by means of heat sealing technique so as to form the joint zones.
US08672909B2 Faecal incontinence collector
The invention relates to an, for patients with faecal/urinary incontinence, auxiliary device in the form of a, on the skin around the anus, glued collection bag made of suitable and skin-friendly plastic that is foldable 180 degrees in the patient's front or back position.The design eliminates or substantially reduces the direct contact with faeces and thereby reduces the instances of possible contamination.The collection bag is equipped with channels for water rinsing 9, ointment application 10 and deodorising filters F.The collection bag can be used continuously for several days.The collection bag can easily be removed from the patient by means of the top 6 being made of light-sensitive adhesives.When the collection bag is removed, the bag can easily be sealed with the lid 8 and transported by means of the carrying handle 7.
US08672908B2 Convex barrier ring
A convex barrier ring, that includes a generally oval shaped body and tapered peripheral end portions, is provided. In use, the convex barrier ring is sealed against peristomal skin surfaces such that the tapered peripheral end portions are aligned with folds or creases in the skin surfaces to reduce leakage of stomal effluent. The convex barrier can also have an oval stoma-receiving aperture to provide an improved fit for oval or loop stomas.
US08672904B1 Splash shield systems
A medical system comprising apparatus and methods for improved irrigation and lavage in wound management. The device attaches to at least one irrigation fluid source and is configured to administer the fluid indirectly to a wound or tissue.
US08672899B2 Medication injector apparatus with drive assembly that facilitates reset
A medication injector apparatus such as an injection pen. The injection pen may include a doseable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose.
US08672895B2 Needle guard
A needle guard assembly having a resilient arm extending from a base situated to slide along the shaft of a needle. In one implementation the needle guard has an elongate containment member that rides with the resilient arm and is co-operable with the resilient arm to effectuate a covering of the entire distal tip of the needle upon the needle being retracted into the needle guard.
US08672889B2 Soft tissue tunneling device
A tissue tunneling device is configured to be delivered within the body. The tunneling device includes a shaft with a blunt distal end to prevent coring or other damage to tissue during the delivery of the tunneling device. In some arrangements, the shaft includes one or more lumen, through which medication or another fluid may be administered. An anesthetic or other pain relieving medication may be delivered through the lumen to lessen the discomfort of delivering the tunneling device to the desired anatomical site. The handle of the tunneling device can be adapted to receive a syringe or another type of fluid source. The shaft may also include a retractable needle for facilitating the advancement of the tunneling device through skin or other tissue. The shaft may also be provided with an outer sheath, which may be left within the anatomy after the tunneling device has been removed. The tunneling device can be configured to prevent or reduce relative rotation or other movement between the shaft and the sheath. The shaft may be malleable for custom-shaping the tunneling device prior to and/or during delivery.