| Document | Document Title |
|---|---|
| US08581285B2 |
Semiconductor light-emitting element for flip-chip mounting
The present invention is directed to the provision of a semiconductor light-emitting element that has an electrode formed with a desired thickness using a plated metal layer. A semiconductor light-emitting element for flip-chip mounting on a circuit substrate includes a semiconductor layer including a light-emitting layer, an N-side bump electrode for connecting the semiconductor layer to the circuit substrate, and a P-type bump electrode for connecting the semiconductor layer to the circuit substrate, wherein the N-side bump electrode and the P-type bump electrode each include an under-bump metal layer and a plated metal layer, the under-bump metal layer includes a high-reflectivity metal layer disposed on a side that faces the semiconductor layer and a metal layer disposed on a side opposite from the semiconductor layer, and the plated metal layer has a thickness not less than 3 μm but not greater than 30 μm. |
| US08581284B2 |
Semiconductor light-emitting device and manufacturing method
A semiconductor light-emitting device and a method for manufacturing the same can include a wavelength converting layer encapsulating at least one semiconductor light-emitting chip in order to emit various colored lights including white light. The semiconductor light-emitting device can include a base board, a frame located on the base board, the chip mounted on the base board, the wavelength converting layer formed around the chip, a transparent plate located on the wavelength converting layer and a diffusing reflection member disposed between the frame and both side surfaces of the wavelength converting layer and the transparent plate. The device can be configured to improve the linearity of a boundary between the diffusing reflection member and both side surfaces by using the transparent plate, and therefore can be used for a headlight that can form a favorable horizontal cut-off line corresponding to the boundary via a projector lens without a shade. |
| US08581279B2 |
Light-emitting diode chip comprising a contact structure
In a luminescence diode chip having a radiation exit area (1) and a contact structure (2, 3, 4) which is arranged on the radiation exit area (1) and comprises a bonding pad (4) and a plurality of contact webs (2, 3) which are provided for current expansion and are electrically conductively connected to the bonding pad (4), the bonding pad (4) is arranged in an edge region of the radiation exit area (1). The luminescence diode chip has reduced absorption of the emitted radiation (23) in the contact structure (2, 3, 4). |
| US08581277B2 |
Light emitting device and light emitting device package having the same
Disclosed are a light emitting device. The light emitting device includes a light emitting structure including a first and second conductive semiconductors, and an active layer; an insulating layer on a lateral surface of the light emitting structure; an electrode on the first conductive semiconductor layer; an electrode layer under the second conductive semiconductor layer; and a protective layer including a first portion between the light emitting structure and the electrode layer and a second portion extending outward beyond a lower surface of the light emitting structure, wherein the first conductive semiconductor layer includes a first top surface including a roughness on a first region, and a second top surface lower than the first region and being closer the lateral surface of the light emitting structure than the first region, wherein the second top surface is disposed on an edge portion of the first conductive semiconductor layer. |
| US08581270B2 |
Organic light-emitting display apparatus
An organic light-emitting display apparatus is disclosed. The organic light-emitting display apparatus includes a first sub-pixel, a second sub-pixel, and a third sub-pixel, where each of said first, second and third sub-pixels displays a different color, a substrate, a first electrode disposed on the substrate, a second electrode disposed on the first electrode, facing the first electrode, an organic emission layer disposed between the first electrode and the second electrode, including a first organic emission layer, a second organic emission layer, and a third organic emission layer, and an electron acceptor layer disposed between the first electrode and the second electrode configured to contact the organic emission layer, where the first organic emission layer is disposed in the first sub-pixel, the second organic emission layer is disposed in the second sub-pixel, and the third organic emission layer is commonly disposed over the first sub-pixel, the second sub-pixel, and the third sub-pixel, and where the electron acceptor layer is disposed between the first organic emission layer and the third organic emission layer in the first sub-pixel and between the second organic emission layer and the third organic emission layer in the second sub-pixel. |
| US08581269B2 |
Modular high density LED array light sources
A modular LED array light source comprises an assembly of a plurality of solid-state LED array modules. Modules are abutted to provide a large area, high intensity and high-density array that provides substantially uniform irradiance. Preferably, in each module, a linear or rectangular array of groups of LED is provided in which the density of LED die in the array is higher at ends or edges of the modules abutting other modules, to provide improved uniformity of irradiance over the illuminated area between modules. Particular arrangements of clusters of LEDs are provided that reduce or overcome the discontinuity or dip in irradiance due to edge or wall effects caused by the spacing of LED die from edges of the substrate/packaging of each module. These arrangements are advantageous for hermetically sealed LED array modules, for example, which require a minimum wall thickness for an effective seal. |
| US08581265B2 |
Light-emitting device and electronic device including substrate having flexibility
It is an object to provide a flexible light-emitting device with long lifetime in a simple way and to provide an inexpensive electronic device with long lifetime using the flexible light-emitting device. A flexible light-emitting device is provided, which includes a substrate having flexibility and a light-transmitting property with respect to visible light; a first adhesive layer over the substrate; an insulating film containing nitrogen and silicon over the first adhesive layer; a light-emitting element including a first electrode, a second electrode facing the first electrode, and an EL layer between the first electrode and the second electrode; a second adhesive layer over the second electrode; and a metal substrate over the second adhesive layer, wherein the thickness of the metal substrate is 10 μm to 200 μm inclusive. Further, an electronic device using the flexible light-emitting device is provided. |
| US08581264B2 |
Semiconductor body and method of producing a semiconductor body
A semiconductor body includes an n-conductive semiconductor layer and a p-conductive semiconductor layer. The p-conductive semiconductor layer contains a p-dopant and the n-conductive semiconductor layer an n-dopant and a further dopant. |
| US08581262B2 |
Electronic devices comprising multi cyclic hydrocarbons
The present invention relates to compositions comprising functionalized or un-functionalized multi cyclic hydrocarbons and functional organic compounds, which can be used in different electronic devices. The invention further relates to an electronic device comprising one or more organic functional layers, wherein at least one of the layers comprises at least one functionalized or un-functionalized multi cyclic hydrocarbon. Another embodiment of the present invention relates to a formulation comprising functionalized or un-functionalized multi cyclic hydrocarbons, from which a thin layer comprising at least one functionalized or un-functionalized multi cyclic hydrocarbon can be formed. |
| US08581261B2 |
Compound semiconductor device and method of manufacturing the same
Two layers of protection films are formed such that a sheet resistance at a portion directly below the protection film is higher than that at a portion directly below the protection film. The protection films are formed, for example, of SiN film, as insulating films. The protection film is formed to be higher, for instance, in hydrogen concentration than the protection film so that the protection film is higher in refractive index the protection film. The protection film is formed to cover a gate electrode and extend to the vicinity of the gate electrode on an electron supplying layer. The protection film is formed on the entire surface to cover the protection film. According to this configuration, the gate leakage is significantly reduced by a relatively simple configuration to realize a highly-reliable compound semiconductor device achieving high voltage operation, high withstand voltage, and high output. |
| US08581258B2 |
Semiconductor device structures and methods of forming semiconductor structures
A method of patterning a semiconductor film is described. According to an embodiment of the present invention, a hard mask material is formed on a silicon film having a global crystal orientation wherein the semiconductor film has a first crystal plane and second crystal plane, wherein the first crystal plane is denser than the second crystal plane and wherein the hard mask is formed on the second crystal plane. Next, the hard mask and semiconductor film are patterned into a hard mask covered semiconductor structure. The hard mask covered semiconductor structured is then exposed to a wet etch process which has sufficient chemical strength to etch the second crystal plane but insufficient chemical strength to etch the first crystal plane. |
| US08581252B2 |
Active device array substrate, color filter substrate and manufacturing methods thereof
An active device array substrate comprising a substrate, a pixel array, a partition configuration and an alignment material layer is provided. The substrate has an alignment region and a predetermined sealing region. The predetermined sealing region surrounds the alignment region. The pixel array is disposed on the substrate within the alignment region. The partition configuration is disposed on the substrate between the predetermined sealing region and the alignment region. The alignment material layer is disposed within the alignment region and covers the pixel array. |
| US08581246B2 |
Protective barriers for electronic devices
The present disclosure provides for electronic devices that use low cost, conductive materials as transparent conductors. The devices contain corrosion preventative conductive polymer layers and conductive innerlayer barriers that separate corrosive electrolyte from the conductors which are prone to corrosion and dissolution, while providing an uninterrupted electrical circuit. The present disclosure also allows for the use of layers which have been applied from aqueous media thereby reducing both the cost and the environmental impact of the electronic devices. Methods of manufacture are also provided. |
| US08581243B2 |
Thin-film transistor and process for its fabrication
A bottom gate type thin-film transistor constituted of at least a substrate, a gate electrode, a gate insulating layer, a semiconductor layer, a source electrode and a drain electrode. At an interface between the gate electrode and the gate insulating layer, the interface has a difference between hill tops and dale bottoms of unevenness in the vertical direction, of 30 nm or less. |
| US08581241B2 |
Polymer compound, net-like polymer compound produced by crosslinking the polymer compound, composition for organic electroluminescence element, organic electroluminescence element, organic EL display, and organic EL lighting
An object of the invention is to provide a polymer compound having a high hole transport capacity, excellent in electrochemical stability, and suitable to film formation according to a wet film formation method. Another object of the invention is to provide an organic electroluminescence element having a high current efficiency, a low drive voltage, and a long derive lifetime. The polymer compound has a crosslinking group bonding to the arylamine moiety in the repeating unit via at least one single bond therebetween. |
| US08581233B2 |
Variable capacitor single-electron transistor including a P-N junction gate electrode
The present invention provides a single-electron transistor device 100. The device comprises a source 105 and drain 110 located over a substrate 115 and a quantum island 120 situated between the source and drain, to form tunnel junctions 125, 130 between the source and drain. The device further includes a fixed-gate electrode 135 located adjacent the quantum island 120. The fixed-gate electrode has a capacitance associated therewith that varies as a function of an applied voltage to the fixed-gate electrode. The present invention also includes a method of fabricating a single-electron device 300, and a transistor circuit 800 that include a single-electron device 810. |
| US08581232B2 |
Semiconductor light emitting device and method for manufacturing the same
A semiconductor light emitting device includes a first semiconductor layer; a second semiconductor layer on the first semiconductor layer; an active layer on the second semiconductor layer; a third semiconductor layer on the active layer; and a fourth semiconductor layer on the third semiconductor layer, wherein the first semiconductor layer has a composition equation of AlY(GaxIn1-x)1-YN(0≦X,Y≦1), wherein the third semiconductor layer has a composition equation of AlY(GaxIn1-x)1-YN(0≦X,Y≦1), wherein the active layer includes a plurality of quantum barrier layers and a plurality of quantum well layers having a material different from the quantum barrier layers, wherein the plurality of quantum well layers include an AlGaN based semiconductor layer, wherein the plurality of quantum barrier layers has a larger band gap energy than that of the quantum well layers. |
| US08581231B2 |
Light emitting device with electrode having plurality of adhesive seeds spaced from one another on the light emitting structure
Disclosed is a light emitting device including a light emitting structure including a first conductive-type semiconductor layer, a second conductive-type semiconductor layer and an active layer interposed between the first conductive-type semiconductor layer and the second conductive-type semiconductor layer, a first electrode layer electrically connected to the first conductive-type semiconductor layer, and a second electrode layer disposed on the second conductive-type semiconductor layer, wherein the second electrode layer includes a plurality of adhesive seeds spaced from one another on the light emitting structure, a reflective layer disposed on the plurality of adhesive seeds, and a protective layer disposed on the reflective layer, wherein the reflective layer contains silver (Ag) or an Ag alloy. As a result, it is possible to improve light reflectance and electrical properties of the electrode layer of the light emitting device and reliability of the electrode layer. |
| US08581226B2 |
Nonvolatile memory device
According to one embodiment, a nonvolatile memory device includes a word line interconnect layer, a bit line interconnect layer, and a pillar. The word line interconnect layer includes a plurality of word lines extending in a first direction. The bit line interconnect layer includes a plurality of bit lines extending in a second direction. The pillar is disposed between each of the word lines and each of the bit lines. The pillar includes a current selection film and a plurality of variable resistance films stacked on the current selection film. One variable resistance film includes a metal and either oxygen or nitrogen. Remainder of the variable resistance films include the metal, either oxygen or nitrogen, and a highly electronegative substance having electronegativity higher than electronegativity of the metal. A concentration of highly electronegative substance in the remainder of the variable resistance films is different among the variable resistance films. |
| US08581225B2 |
Variable resistance nonvolatile memory device and method of manufacturing the same
A manufacturing method includes forming, on a substrate, lower layer copper lines each being shaped into a strip, forming electrode seed layers each being shaped into a strip, on the respective lower layer copper lines using electroless plating, forming an interlayer insulating layer above the electrode seed layers, forming, in the interlayer insulating layer, memory cell holes, penetrating through the interlayer insulating layer and extending to the electrode seed layers, forming noble metal electrode layers on the electrode seed layers exposed in the respective memory cell holes using the electroless plating, forming, in the respective memory cell holes, variable resistance layers connected to the noble electrode layers, and forming, above the interlayer insulating layer and the variable resistance layers, upper layer copper lines each being shaped into a strip, connected to a corresponding one of the variable resistance layers, and crossing the lower layer copper lines. |
| US08581224B2 |
Memory cells
Some embodiments include memory cells which contain, in order; a first electrode material, a first metal oxide material, a second metal oxide material, and a second electrode material. The first metal oxide material has at least two regions which differ in oxygen concentration relative to one another. One of the regions is a first region and another is a second region. The first region is closer to the first electrode material than the second region, and has a greater oxygen concentration than the second region. The second metal oxide material includes a different metal than the first metal oxide material. Some embodiments include methods of forming memory cells in which oxygen is substantially irreversibly transferred from a region of a metal oxide material to an oxygen-sink material. The oxygen transfer creates a difference in oxygen concentration within one region of the metal oxide material relative to another. |
| US08581221B2 |
Image information detecting apparatus
An image information detecting apparatus with an image information detecting unit that receives recording light representing image information, and records the image information by storing electric charges generated in the unit by the recording light. The apparatus further includes a wireless communication means operable for transmission to an external device; a wire communication means operable for transmission to the external device through a detachable communication cable; a wire transmission setting means for setting the wire communication means operable for transmission; and a wireless transmission prohibiting means. The wireless transmission prohibiting means prohibits wireless transmission from the wireless communication means when the wire communication means is set operable for transmission by the wire transmission setting means. |
| US08581219B2 |
Composite charged-particle-beam apparatus
There is provided a technology which allows SEM observation in real time without deteriorating the processing efficiency in FIB processing. In the present invention, a composite charged-particle-beam apparatus having a FIB column and a SEM column includes an SE3 detector which detects secondary electrons (referred to as tertiary electrons in this specification) discharged when back-scattered electrons generated by irradiating a sample with an electron beam collide with structures in a sample chamber. With use of the tertiary electrons, a SEM image is generated, and based on the SEM image, an ion beam processing state can be observed. |
| US08581217B2 |
Method for monitoring ion implantation
A method capable of monitoring ion implantation. First, an ion beam and a workpiece are provided. Next, implant the workpiece by the ion beam and generate a profile having numerous signals relevant to respectively numerous relative positions between the ion beam and the workpiece, wherein the profile has at least a higher portion, a gradual portion and a lower portion. Therefore, by directly analyzing the profile without referring to a pre-determined profile and without using a profiler measuring the ion beam, some ion beam information may be acquired, such as beam height, beam width, ion beam current distribution on the ion beam cross-section, and so on, and the ion implantation may be monitored real-timely. Furthermore, when numerous workpieces are implanted in sequence, the profile(s) of one or more initially implanted workpiece(s) may be to generate a reference for calibrating the ion implantation of the following workpieces. |
| US08581214B2 |
Staff dose awareness indication
According to an exemplary embodiment of the invention a dose awareness indication device is provided in which an individual dose is determined on the basis of raw dose measuring data, dose sensor and information data from an examination apparatus, wherein the information data from the examination apparatus relates to the type of examination. Thus, an individualized determination of dose data may be provided, depending on the actual examination process. |
| US08581212B2 |
Portable UV monitoring device
The monitoring of UV radiation has received increased attention recently due to the hazards of accelerated skin ageing and even cancer following excessive exposure. Personalized monitoring gives a more accurate reading than crude weather forecasts of the ‘UV index’. This invention answers both these needs in a personal UV monitor that is incorporated into an existing display. Minimal processing changes are made to an existing display in order to achieve this added functionality, which is therefore achieved at little additional cost. |
| US08581209B2 |
Fluorescent monitoring of microcapsule oxidation
The present disclosure relates to microcapsules that include a shell material and a core material. The core material of the microcapsules contains an environmentally sensitive luminescent colorant which exhibits characteristics of an emitted wavelength bandwidth, a peak intensity for emission and a time for luminescence decay, one or more of the characteristics capable of changing upon exposure to a given environment, and a luminescent standard which exhibits characteristics of an emitted wavelength bandwidth, a peak intensity for emission and a time for luminescence decay, one or more of the characteristics do not change upon exposure to said given environment. |
| US08581205B2 |
Transmission electron microscope micro-grid
A transmission electron microscope (TEM) micro-grid includes a grid and a carbon nanotube composite film covered thereon. The carbon nanotube composite film includes a carbon nanotube film and a layer of nano-materials coated thereon. The carbon nanotube composite film covers a surface of the grid. The nano-material layer is coated on a surface of each of the plurality of carbon nanotubes. |
| US08581200B2 |
Radiation detector with multiple electrodes on a sensitive layer
The invention relates to a radiation detector (200), particularly an X-ray detector, which comprises at least one sensitive layer (212) for the conversion of incident photons (X) into electrical signals. A two-dimensional array of electrodes (213) is located on the front side of the sensitive layer (212), while its back side carries a counter-electrode (211). The size of the electrodes (213) may vary in radiation direction (y) for adapting the counting workload of the electrodes. Moreover, the position of the electrodes (213) with respect to the radiation direction (y) provides information about the energy of the detected photons (X). |
| US08581192B2 |
Pyroelectric detector and method for manufacturing same, pyroelectric detection device, and electronic instrument
A pyroelectric detector includes a pyroelectric detection element, a support member, a fixing part and a first reducing gas barrier layer. A first side of the support member faces a cavity and the pyroelectric detection element is mounted and supported on a second side opposite from the first side. An opening part communicated with the cavity is formed on a periphery of the support member in plan view from the second side of the support member. The fixing part supports the support member. The first reducing gas barrier layer covers a first surface of the support member on the first side, a side surface of the support member facing the opening part, and a part of a second surface of the support member on the second side and the pyroelectric detection element exposed as viewed from the second side of the support member. |
| US08581190B2 |
Charged particle beam apparatus and geometrical aberration measurement method therefor
Disclosed is a scanning charged particle microscope provided with an aberration measuring means that measures high-order geometrical aberration at high precision and high speed. An image obtained by a single-hole aperture and an image obtained by a multiple-hole aperture arranged in a region larger than that for the single-hole aperture are deconvoluted, an aberration quantity is determined based on the profiles of beams tilted in a plurality of directions and the obtained quantity is fed back to an aberration corrector. |
| US08581187B2 |
Method for measuring sample and measurement device
An amount of displacement and an overlapping area between first and second patterns formed through a double patterning lithography process can be determined. The first pattern is formed by a first exposure while the second pattern is formed by a later second exposure. A first image of the first pattern is formed prior to the formation of the second pattern. A second image of both patterns is formed after the formation of the second pattern. A two-step matching process between combined information and images of the first and second patterns is performed. The combined information includes information regarding the first pattern, as formed, combined with design information of the second pattern. Based on a moving amount of the design information of the second pattern, a displacement amount between the first and second patterns is determined. |
| US08581179B2 |
Protein sequencing with MALDI mass spectrometry
In a mass spectrometer, sample ions are produced by using matrix assisted laser desorption with a matrix substance that supports spontaneous, non-ergodic ISD fragmentation and a laser light source with nanosecond light pulses and a multiple spot beam profile. A plurality of individual time-of-flight spectra are recorded from the resulting ions in such a way that amplification of ion signals in the mass spectrometer detector is initially reduced so that only ions with masses near a mass range limit are initially recorded. During the repeated acquisitions of the individual time-of-flight spectra, both the detector amplification and the mass range limit are increased. By these methods, it is possible to evaluate c and z fragment ions in lower mass ranges and to directly read N-terminal sequences from near terminus up to 80 amino acids and beyond, and C-terminal sequences up to more than 60 amino acids. |
| US08581176B2 |
Method for high efficiency tandem mass spectrometry
A system and method for performing MS/MS of everything are provided. Ionisable materials separated in order of molecular weight in a plurality of mass ranges are received at a mass spectrometer system in a given order in time, each mass range comprising a respective center mass value and a respective width. The ionisable materials are ionised in the given order that each of the plurality of mass ranges are received, to form respective precursor ions in a respective given mass range. The respective precursor ions are filtered via a mass filter module, a mass scan range of the mass filter module synchronized with the given order in which each of the plurality of mass ranges are received. The respective precursor ions are fragmented, via a fragmentation module, to form respective product ions. The respective product ions are analyzed in a mass spectrometer module to produce product ion spectra. |
| US08581174B2 |
Image sensor with prismatic de-multiplexing
An image sensor includes a first imaging pixel for a first color having a photosensitive region disposed within a substrate of the image sensor and a second imaging pixel for a second color that is different from the first color having a photosensitive region disposed within the substrate. A refraction element disposed adjacent to the substrate, so that the refraction element refracts light of the first color to the photosensitive region of the first imaging pixel and refracts light of the second color to the photosensitive region of the second imaging pixel. |
| US08581172B2 |
High-speed analog photon counter and method
A high speed analog photon counter and method is provided. In one aspect, the method includes delivering an electric charge to a circuit of the high speed analog photon counter through a current source of the circuit. The method also includes accumulating the electric charge in a capacitor of the circuit electrically coupled to the current source. The method further includes comparing the electric charge accumulated in the capacitor of the circuit with a reference voltage through a comparator of the circuit electrically coupled to an output of the capacitor. The output of the capacitor of the circuit is coupled to an input of the comparator of the circuit, and the reference voltage is coupled to another input of the comparator of the circuit. The method furthermore includes resetting the capacitor of the circuit when the electric charge accumulated in the capacitor of the circuit matches the reference voltage. |
| US08581171B2 |
Cyclic A/D converter, image sensor device, and method for generating digital signal from analog signal
A cyclic A/D converter which can reduce the number of reference voltages for D/A conversion is provided. The cyclic A/D converter (11) comprises a gain stage (15), an A/D converter circuit (17), a logic circuit (19), and a D/A converter circuit (21). In an operational action of the gain stage (15), an operational value (VOP) is generated by the use of an operational amplifier circuit (23) and capacitors (25, 27, 29). The gain stage (15) operates as receiving three kinds of voltage signal from the D/A converter circuit (21) by the switching of two kinds of voltage signal (VDA1, VDA2) to be applied to the capacitors (25, 27) in a switching circuit (31). That is, the D/A converter circuit (21) provides a voltage signal (VRH) to the capacitors (25, 27), in response to a value (D=2) of a digital signal (B0, B1), provides voltage signals (VRH, VRL) to the capacitors (25, 27), respectively, in response to a value (D=1) of the signal (B0, B1), and provides the voltage signal (VRL) to the capacitors (25, 27), in response to a value (D=0) of the signal (B0, B1). |
| US08581170B2 |
Semiconductor device having a photodiode electrically connected to a back gate of a transistor and driving method thereof
A transistor a gate of which, one of a source and a drain of which, and the other are electrically connected to a selection signal line, an output signal line, and a reference signal line, respectively and a photodiode one of an anode and a cathode of which and the other are electrically connected to a reset signal line and a back gate of the transistor, respectively are included. The photodiode is forward biased to initialize the back-gate potential of the transistor, the back-gate potential is changed by current of the inversely-biased photodiode flowing in an inverse direction in accordance with the light intensity, and the transistor is turned on to change the potential of the output signal line, so that a signal in accordance with the intensity is obtained. |
| US08581168B2 |
Dual well read-out integrated circuit (ROIC)
A single camera capable of capturing high speed laser return pulses for a target, as well as provide imaging information on the background of the target. This capability is enabled by having a read-out integrated circuit (ROIC) capable of extracting both types of information from a pixel of a focal plane array (FPA). Further, an ROIC topology that allows for the ability to distinguish between high frequency and low frequency signal paths, and provide supporting circuitry to process the two paths separately. One path may integrate the low frequency background scene to provide a high fidelity image of the scene. The second path may process high frequency noise and multiple laser pulse returns within a frame. These two paths may be combined to provide a background image with a superimposed laser return. |
| US08581160B1 |
Gyroscopic stabilizer
A gyroscopic stabilizer has a ring mounted at a missile rocket nozzle exit for rotation about the exit. The ring bears vanes extended inwardly into gases exiting from the nozzle and configured for rotation by the exiting gases so that the rotating mass of the ring gyroscopically stabilizes the missile. The ring may be mounted by a bearing having rolling elements or sliding surfaces. The axial length of the ring may be substantially less than its diameter. The ring has a low moment of inertia and is accelerated to stabilizing speed by vanes minimally impeding the exiting gases. When the stabilizer is used on a rocket propelled missile launched from a tube, the missile is fully stabilized in the tube before burnout and there is no rotational friction between the tube and the missile. |
| US08581156B2 |
Apparatus with heating part
An apparatus has a chassis has a chassis inner face and a chassis outer face, at least one heating part accommodated in the chassis, wherein at least a portion of the heating part faces the chassis inner face with an internal space therebetween, and a film having a first face and a second face bonded to at least a portion of the heating part facing the chassis inner face. The chassis outer face is located on a side opposite the chassis inner face portion and in contact with an external space and having a radiation film interposed therebetween. The film includes a convex part, a concave part, or a repeated pattern of convex and concave parts in the first face or the second face. At least one of the first face and the second face is in contact with the internal space. |
| US08581154B2 |
Method for effectuating temperature control in roller grills
The present invention provides a method for effectuating temperature control in roller grill assembly. Some embodiments provide a roller grill assembly which provides enhanced measurement by utilizing temperature probes located in convective air streams generated in the roller tube. Certain embodiments also provide an improved method for maintaining of a food product temperature by utilizing an intermediate holding mode. Finally, certain embodiments provide improved current control by limiting the number of heating circuits of a food heater that may be simultaneously enabled such that the current draw does not exceed a maximum current draw. |
| US08581149B2 |
Exothermic welding assembly
An assembly is disclosed for exothermic welding comprising a mold which is formed of a material which withstands exothermic welding temperatures and includes a weld cavity therein for positioning at least two members which are to be exothermically welded together, and an ignition cavity communicating with the weld cavity. The mold is capable of accommodating any one of several exothermic welding procedures which may involve either a flint igniter or the use of an electrical igniter which is readily accommodated by the mold in the performance of several of the procedures. The electrical igniter is formed of a pair of flat, longitudinally extending conductor strips with a sheet of insulation laminated therebetween, a filament adjacent one end of the strips, and one or more positioning tabs adjacent one end of the strips. A cartridge is also provided which contains the weld metal and the electrical igniter and which may be positioned in the ignition cavity of the mold. The cartridge is formed of a material which is consumed during the welding procedure and may contain a plate of a different material adjacent its bottom which melts at a higher temperature than the materials of the cartridge. |
| US08581147B2 |
Three stage power source for electric ARC welding
A three stage power source for an electric arc welding process comprising an input stage having an AC input and a first DC output signal; a second stage in the form of an unregulated DC to DC converter having an input connected to the first DC output signal, a network of switches switched at a high frequency with a given duty cycle to convert the input into a first internal AC signal, an isolation transformer with a primary winding driven by the first internal high frequency AC signal and a secondary winding for creating a second internal high frequency AC signal and a rectifier to convert the second internal AC signal into a second DC output signal of the second stage, with a magnitude related to the duty cycle of the switches; and, a third stage to convert the second DC output signal to a welding output for welding wherein the input stage has a regulated DC to DC converter with a boost power switch having an active soft switching circuit. |
| US08581146B2 |
Automatic wire feeding system
An apparatus and method for feeding welding wire, where the apparatus contains a wire feeding device which pays out a wire and a power source which provides a current and voltage to the wire while it is being paid out. The apparatus further includes a detection circuit which detects a short circuit in the wire when the wire makes contact with a work piece or the like, and upon detection of the short circuit the wire feeding device stops feeding the wire so that a desired stick out distance is achieved. |
| US08581145B2 |
System and method for tracking welding-type parameters, machine setup and job packet coding for workflow
A system and method for identifying, recording, and storing specific settings for an interface device of a welding-type system includes a bezel forming a marking surface that extends about a portion of a periphery of the interface device to display user markings and allow the markings to be selectively erased. The marking surface may be designed to receive color-coded markers that engage the marking surface through suction, magnetism, or peg-and-receptacle couplings to indicate desired settings of the interface device to perform a specific welding-type process. Additionally, if the interface device is a dial, a pointer may be coupled with the dial that is movable independently from the dial to indicate a desired dial setting. |
| US08581141B2 |
Laser machining apparatus using laser beam introduced into jet liquid column
A laser machining apparatus comprising jet liquid, a laser beam, and a laminar flow forming channel for supplying jet liquid to a nozzle. The channel includes a distribution channel formed by a cavity, an interconnecting channel disposed to communicate with said channel downstream in an axial direction of the nozzle and formed by an annular cavity around the axis of the nozzle to provide a narrower flow passage, and a liquid reservoir chamber. Said chamber has an outer peripheral edge communicating with the interconnecting channel over an entire circumference of the annular shape. An outer peripheral surface and an outer peripheral surface of the chamber form a continuous surface and an inner peripheral wall surface and an inner peripheral surface of the channel are both formed as an inclined inward surface that is downstream, the inner peripheral surface and the inner peripheral wall surface forming a planar continuous surface. |
| US08581137B2 |
Method for operating a heating device of an electric heating appliance having a plurality of heating devices
In an operating method for a hob having a plurality of heating elements, an operating action for a heating element, such as heating with an additional region on the cooktop or invoking a parboiling step, is selected in an initial step by providing input to a general input sensor element that is not associated with any specific heating element. In a subsequent step, the selected operating action is allocated or associated with a specific heating element by operating a cooking element specific sensor element, for example when setting the power level for that heating element. Therefore, sensor elements can be provided with an advantageous multiple-use effect for general operating actions. Furthermore, the operating sequence permits simple and convenient operation. |
| US08581134B2 |
Method and apparatus for dry granulation
The invention provides, inter alia, a method for producing granules from a powder, characterized in that compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating and removing fine particles and/or small granules from the other granules by entraining the fine particles and/or small granules in a gas stream. Also provided are apparatus for use in the process and tablets formed by compression of the resultant granules. |
| US08581133B2 |
Operator control apparatus of an electronic domestic appliance and method of producing the operator control apparatus
An operator control apparatus of an electronic domestic appliance contains an operator control panel on that side of the operator control apparatus which faces a user, at least one electrically conductive sensor element on that side of the operator control panel which is averted from the user, and a printed circuit board with at least one electrically conductive contact area which is arranged on that side of the printed circuit board which faces the operator control panel so as to be associated with the at least one sensor element. In this case, the at least one sensor element and the at least one contact area of the printed circuit board are connected to one another by an adhesive which is electrically conductive at least in the connection direction. |
| US08581127B2 |
Key structure with scissors-type connecting member
A key structure includes a keycap, a scissors-type connecting element, a membrane module, a light-emitting element and a base plate. The light-emitting element is used for emitting light beams. The keycap has a protrusion structure for blocking the light beams and preventing the light beams from leaking out through the gap between said keycap and said base plate. The base plate has a slot corresponding to the protrusion structure. When the keycap is depressed, the membrane module is pressed by the protrusion structure to be subject to deformation, so that a deformed part of the membrane module is inserted into the slot of the base plate. In such way, the hand feel of depressing the keycap is not adversely affected. |
| US08581126B1 |
Integrated automotive horn/light apparatus and method
An apparatus and method for simultaneously operating the horn and light systems of a motorized vehicle is provided. The controller used to operate the systems can be a single controller that operates the horn when a certain range of pressure is applied to the controller and operates the horn and lights systems when a stronger pressure is applied. The system can include a dedicated horn operating system controller independent of the dual function controller to eliminate the need for differing pressures to operate the horn and light systems substantially simultaneously. Also disclosed are apparatuses and methods to coordinate a vehicle braking system with the vehicle horn and light systems to improve the reception of safety and/or emergency warnings. |
| US08581124B2 |
Terminal device
A terminal device includes a first housing, a key attached to a cut portion in a corner of the first housing, a key support portion configured to support the key, the key support portion including a shaft portion having a rotation axis on a side of a side face of the corner and attached to a bearing portion provided in the first housing and a peripheral edge portion caught by a peripheral edge of the cut portion, a transmitting portion configured to transmit a predetermined pressing force to a switch provided on the substrate via the key support portion when the predetermined pressing force is applied to the key in a rotation direction determined by the rotation axis, and a second housing combined with the first housing to which the key and the key support portion are attached so as to store the transmitting portion, the substrate, and the switch. |
| US08581122B2 |
Feed bin monitoring system and method
A bin monitoring system functions both as a device for lifting the bin and as a weighing system for monitoring or measuring the level of feed in a feed bin. Various embodiments having a suspended load cell and methods of retrofitting the bin monitoring system to existing bins are provided. Further, the accuracy provided by various embodiments enables one to accurately predict when the feed bin will be empty. Thus, the feed mill can be aware of anticipated needs days in advance, allowing the feed mill to better optimize its scheduling and deliveries. |
| US08581114B2 |
Packaged structure having magnetic component and method thereof
A packaged structure having a magnetic component and a method of manufacturing the same are provided. The packaged structure includes an insulating substrate having a ring-typed recess, an island portion and a surrounding portion defined by the ring-typed recess, wherein the ring-typed recess is laterally between the island portion and the surrounding portion. The packaged structure further includes a ring-typed magnetic component placed in the ring-typed recess; an upper wiring layer above the insulating substrate and a lower wiring layer under the insulating substrate; an inner plated through hole vertically passing through the island portion and connecting the upper wiring layer and the lower wiring layer; an outer plated through hole vertically passing through the surrounding portion and connecting the upper wiring layer and the lower wiring layer, wherein the inner plated through hole, the outer plated through hole, the upper wiring layer and the lower wiring layer form a coil of wire surrounding the ring-typed magnetic component. |
| US08581113B2 |
Low cost high frequency device package and methods
A low-cost high-frequency electronic device package and associated fabrication method are described wherein waveguide structures are formed from the high frequency device to the package lead transition. The package lead transition is optimized to take advantage of waveguide interconnect structure. |
| US08581111B2 |
Mounting structure
A mounting structure includes an electronic component mounted on a circuit board. Land electrodes are disposed on a board body and are connected to outer electrodes of the electronic component through solders, respectively. A distance from each of the land electrodes to a top of the corresponding solder is not larger than about 1.27 times a distance from each of the land electrodes to an exposed portion of a capacitor conductor exposed at an end surface of the electronic component, the capacitor conductor being positioned closest to the circuit board. |
| US08581109B2 |
Method for manufacturing a circuit board structure
The present publication discloses a method for manufacturing a circuit-board structure. In the method, a conductor layer is made, which comprises a conductor foil and a conductor pattern on the surface of the conductor foil. A component is attached to the conductor layer and at least some conductor material of the conductor layer is removed from outside the conductor pattern. |
| US08581107B2 |
Halogen-free flame-retardant epoxy resin composition, and prepreg and printed circuit board using the same
Disclosed is a halogen-free flame-retardant epoxy resin composition for printed circuit board, which includes (A) a halogen-free epoxy resin; (B) a copolymer of styrene and maleic anhydride used as a first curing agent; (C) poly(1,3-phenylene methylphosphonate) used as a second curing agent; (D) a curing accelerator; and (E) an inorganic filler. |
| US08581106B2 |
Submount
A submount with an electrode layer having excellent wettability in soldering and method of manufacturing the same are disclosed. A submount (1) for having a semiconductor device mounted thereon comprises a submount substrate (2), a substrate protective layer (3) formed on a surface of the submount substrate (2), an electrode layer (4) formed on the substrate protective layer (3) and a solder layer (5) formed on the electrode layer (3) wherein the electrode layer (4) is made having an average surface roughness of less than 1 μm. The reduced average surface roughness of the electrode layer (4) improves wettability of the solder layer (5), allowing the solder layer (5) and a semiconductor device to be firmly bonded together without any flux therebetween. A submount (1) is thus obtained which with the semiconductor device mounted thereon is reduced in heat resistance, reducing its temperature rise and improving its performance and service life. |
| US08581104B2 |
Wiring board and method for manufacturing the same
A wiring board includes an insulation layer containing a resin and a silica-type filler and having a roughened surface, and a conductive layer formed on the roughened surface of the insulation layer and having a first conductive portion and a second conductive portion positioned adjacent to the first conductive portion. The roughened surface of the insulation layer has a roughness under the first conductive portion, a roughness under the second conductive portion, and a roughness between the first conductive portion and the second conductive portion, and the roughness between the first conductive portion and the second conductive portion is set less than at least one of the roughness under the first conductive portion and the roughness under the second conductive portion. |
| US08581103B2 |
Parts made of electrostructural composite material
A ridge structural part made of laminated composite material incorporates electrically conducting cables, the structural part includes at least two structural layers including fibers held in place by a thermosetting or thermoplastic matrix, at least one conducting network layer located between two of the at least two structural layer, the at least one conducting network layer including a network of electrically conducting cables, said electrically conducting cables being arranged throughout said structural part in a substantially regular manner and being electrically insulated from said two structural layers by a dielectric material. The structural part also includes electrical connections, to which electrically conducting cables of the at least one network layer are electrically connected so as to form an electrical network by assembling several structural parts. |
| US08581100B2 |
Manufacturing method and cover for electronic device
A cover for an electronic device includes a display window and a cover body injection molded with the display window. The display window includes a window body and at least one protruding portion projecting form the window body. The cover body includes a cover wall and ribs. The window body includes a front surface, a rear surface and a peripheral surface connecting the front surface and the rear surface. The at least one protruding portion is fixed on the peripheral surface and embedded between the cover wall and the ribs. |
| US08581099B2 |
Photovoltaic junction box
A photovoltaic junction box includes a housing, a circuit board received in the housing, a plurality of metal brackets, and a plurality of bypass diodes. The plurality of metal brackets are secured to the circuit board, each of the plurality of metal brackets defines a receiving space receiving a spring sheet. The plurality of bypass diodes are respectively secured to the plurality of metal brackets and electrically connected to the circuit board. Each of a plurality of ribbons is clamped between the spring sheet and a corresponding metal bracket, and the ribbon directly and electrically contacts the corresponding metal bracket. |
| US08581092B2 |
Tandem solar cell and method of manufacturing same
A tandem solar cell includes: a substrate; a front electrode disposed on the substrate; a back electrode disposed opposite to the front electrode on the substrate; a first cell disposed below the front electrode and including a first buffer layer and a first light absorption layer; and a second cell disposed above the back electrode and including a second light absorption layer and a second buffer layer. The first light absorption layer includes a CuGaSeS layer and a CuGaSe layer, and the second light absorption layer includes a semiconductor compound selected from the group consisting of CuInSe2, CuInGaSe2, CuInSeS, CuInGaSeS and any combinations thereof. The CuGaSeS layer of the first light absorption layer is disposed closer than the CuGaSe layer of the first light absorption layer to the front electrode. |
| US08581091B2 |
Serial circuit of solar cells with integrated semiconductor bodies, corresponding method for production and module with serial connection
The invention relates to a method for production of a serial circuit of solar cells with integrated semiconductor bodies, a serial circuit produced thus and photovoltaic modules, comprising at last one serial circuit. The invention is characterized in that conducting bodies (20) and semiconducting bodies (30) are applied to an insulating support layer, according to a pattern, whereby said pattern provides at least one dividing line (21) of conducting bodies. The regions adjacent to the conducting bodies are provided with spherical or particle-shaped semiconducting bodies (30). Parts of the semiconductor bodies are removed and the support layer coated on the side with a back contact layer (50). The back contact layer of a semiconducting body is thus exposed, for example, and brought into contact with the back contact layer (50) of the solar cell. The other side of the support layer (10) is provided with a front contact layer. By the introduction of two separating layers along a row of conducting bodies, the flow of current from the solar cells produced with the integrated semiconductor bodies can run such that the cell regions between the conducting body rows are connected in series. Individual series circuits can be connected to each other in the manner of tiles, such that each back contact is connected to a front contact. |
| US08581089B2 |
Module having a plurality of thermoelectric elements
A module having a plurality of thermoelectric elements electrically connected in series, each being made of at least one n-layer and at least one p-layer made of thermoelectric material with a pn-transition implemented along a boundary layer. A temperature gradient parallel to the boundary layer between a hot and a cold side of each thermoelectric element can be applied or detected. Resistances of the electrical contacts of the individual thermoelectric elements are reduced and the thermal connection to a heat sink or heat source is improved for generating a temperature gradient along the boundary layer. The substrate and the thermoelectric elements are produced in separate processes, and the thermoelectric elements are adhered to previously structured, thermally and electrically conductive regions of the substrate using different adhesives for the cold and hot side of each thermoelectric element. |
| US08581083B2 |
Stringed instrument practice device
The present invention extends to handheld practice devices for practicing to play stringed instruments. More specifically, the present invention relates to a practice device that may assist a user in learning how to properly finger and play a stringed musical instrument. A user can hold an elongate handle and place one or more of his or her fingers on strings to practice fingerings that are used to play chords/notes. Real instrument strings can be used, helping to strengthen a user's fingertips and get the fingertips accustomed to holding/pinching the instrument strings. Further, the stringed instrument practice device can be portable and sized to fit within the user's hand. Accordingly, a user can realize advantages of the invention and utilize practice methods while the user is “on the go,” riding on a bus, watching television, waiting in line, etc. |
| US08581079B2 |
Maize variety X4S790
A novel maize variety designated X4S790 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing maize variety X4S790 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X4S790 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X4S790, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X4S790. This invention further relates to methods for producing maize varieties derived from maize variety X4S790 and to the maize varieties derived by the use of those methods. |
| US08581078B2 |
Sweet corn hybrid SEB6SH1102 and parents thereof
The invention provides seed and plants of sweet corn hybrid SEB6SH1102 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of sweet corn hybrid SEB6SH1102 and the parent lines thereof, and to methods for producing a sweet corn plant produced by crossing such plants with themselves or with another sweet corn plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the parts of such plants. |
| US08581075B2 |
Plants and seeds of corn variety CV497880
According to the invention, there is provided seed and plants of the corn variety designated CV497880. The invention thus relates to the plants, seeds and tissue cultures of the variety CV497880, and to methods for producing a corn plant produced by crossing a corn plant of variety CV497880 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV497880 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV497880. |
| US08581071B2 |
Plants and seeds of corn variety CV240831
According to the invention, there is provided seed and plants of the corn variety designated CV240831. The invention thus relates to the plants, seeds and tissue cultures of the variety CV240831, and to methods for producing a corn plant produced by crossing a corn plant of variety CV240831 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV240831 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV240831. |
| US08581070B2 |
Plants and seeds of corn variety CV368215
According to the invention, there is provided seed and plants of the corn variety designated CV368215. The invention thus relates to the plants, seeds and tissue cultures of the variety CV368215, and to methods for producing a corn plant produced by crossing a corn plant of variety CV368215 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV368215 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV368215. |
| US08581068B1 |
Maize variety hybrid X18B721
A novel maize variety designated X18B721 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X18B721 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X18B721 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X18B721, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X18B721. This invention further relates to methods for producing maize varieties derived from maize variety X18B721. |
| US08581064B1 |
aize variety inbred PH18MF
A novel maize variety designated PH18MF and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH18MF with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH18MF through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH18MF or a locus conversion of PH18MF with another maize variety. |
| US08581061B1 |
Inbred corn line 1AA001
An inbred corn line, designated 1AA001, the plants and seeds of the inbred corn line 1AA001, methods for producing a corn plant, either inbred or hybrid, produced by crossing the inbred corn line 1AA001 with itself or with another corn plant, and hybrid corn seeds and plants produced by crossing the inbred line 1AA001 with another corn line or plant and to methods for producing a corn plant containing in its genetic material one or more transgenes and to the transgenic corn plants produced by that method. This invention also relates to inbred corn lines derived from inbred corn line 1AA001, to methods for producing other inbred corn lines derived from inbred corn line 1AA001 and to the inbred corn lines derived by the use of those methods. |
| US08581059B2 |
Tomato line FDR 14-2098
The invention provides seed and plants of tomato hybrid EX15567631 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of tomato hybrid EX15567631 and the parent lines thereof, and to methods for producing a tomato plant produced by crossing such plants with themselves or with another tomato plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the fruit and gametes of such plants. |
| US08581052B1 |
Soybean variety XB35F12
A novel soybean variety, designated XB35F12 is provided. Also provided are the seeds of soybean variety XB35F12, cells from soybean variety XB35F12, plants of soybean XB35F12, and plant parts of soybean variety XB35F12. Methods provided include producing a soybean plant by crossing soybean variety XB35F12 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB35F12, methods for producing other soybean varieties or plant parts derived from soybean variety XB35F12, and methods of characterizing soybean variety XB35F12. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB35F12 are further provided. |
| US08581051B2 |
Soybean variety XB07D12
A novel soybean variety, designated XB07D12 is provided. Also provided are the seeds of soybean variety XB07D12, cells from soybean variety XB07D12, plants of soybean XB07D12, and plant parts of soybean variety XB07D12. Methods provided include producing a soybean plant by crossing soybean variety XB07D12 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB07D12, methods for producing other soybean varieties or plant parts derived from soybean variety XB07D12, and methods of characterizing soybean variety XB07D12. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB07D12 are further provided. |
| US08581050B2 |
Soybean variety XBO6F12
A novel soybean variety, designated XB06F12 is provided. Also provided are the seeds of soybean variety XB06F12, cells from soybean variety XB06F12, plants of soybean XB06F12, and plant parts of soybean variety XB06F12. Methods provided include producing a soybean plant by crossing soybean variety XB06F12 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB06F12, methods for producing other soybean varieties or plant parts derived from soybean variety XB06F12, and methods of characterizing soybean variety XB06F12. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB06F12 are further provided. |
| US08581049B1 |
Maize variety hybrid X08B802
A novel maize variety designated X08B802 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X08B802 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X08B802 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X08B802, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X08B802. This invention further relates to methods for producing maize varieties derived from maize variety X08B802. |
| US08581043B2 |
Nicotiana nucleic acid molecules and uses thereof
The present invention features Nicotiana nucleic acid sequences such as sequences encoding constitutive, or ethylene or senescence induced polypeptides, in particular cytochrome p450 enzymes, in Nicotiana plants and methods for using these nucleic acid sequences and plants to alter desirable traits, for example by using breeding protocols. |
| US08581037B2 |
Promotion of somatic embryogenesis in plants by Wuschel gene expression
The present invention relates to methods for promoting somatic embryogenesis from a tissue or organ of a plant, by overexpressing a Wuschel gene in said tissue or organ. In one embodiment, such overexpression can be used as a silent selectable marker for transgenic plants. In another embodiment, such expression can be used to confer apomixis to a plant. In another embodiment, such overexpression can be used to create haploid plants, which can be used to produce dihaploid plants. |
| US08581036B2 |
Plant peptide gamma-zein for delivery of biomolecules into plant cells
A method of introducing a molecule of interest into a plant cell having a cell wall includes interacting a gamma-zein peptide with a molecule of interest to form a gamma-zein linked structure. The gamma-zein linked structure is then placed in contact with the plant cell having a cell wall, and allowing uptake of the gamma-zein linked structure into the plant cell. Alternatively, a gene of interest can be expressed in a plant cell having an intact cell wall by interacting a gamma-zein peptide with the gene of interest to form a gamma-zein linked gene structure, allowing uptake of the gamma-zein linked gene structure into the plant cell, and expressing the gene of interest in the plant cell and its progeny. |
| US08581035B2 |
Plant transformation without selection
The invention provides methods for identifying regenerated transformed plants and differentiated transformed plant parts, obtained without subjecting plant cells to selective conditions prior to regenerating the cells to obtain differentiated tissues. In particular embodiments, the plant cells are corn plant cells. Methods for growing and handling plants, including identifying plants that demonstrate specific traits of interest are also provided. |
| US08581032B1 |
Maize variety inbred PH13FW
A novel maize variety designated PH13FW and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH13FW with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH13FW through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH13FW or a locus conversion of PH13FW with another maize variety. |
| US08581030B1 |
Maize variety hybrid X03B437
A novel maize variety designated X03B437 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X03B437 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X03B437 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X03B437, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X03B437. This invention further relates to methods for producing maize varieties derived from maize variety X03B437. |
| US08581018B2 |
Absorber comprising pulp, tea dregs and water absorbent resin; sanitary articles using the absorber and production method thereof
An absorber wherein crushed tea leaves having a particle size of 0.05 to 4.6 mm are dispersed and held within a pulp fiber material having a fiber length of 0.1 to 7 mm, for water-absorbing, drying, and odor-eliminating with good visual quality, and maintaining sanitary conditions, and sanitary articles using the absorber. An upper water-absorbing paper layer portion forms an upper surface, a lower water-absorbing paper layer portion forms a lower surface, and a water-absorbing mixture layer portion is provided between the upper water-absorbing paper layer portion. The layer portions are overlapped and integrated forming the absorber. The water-absorbing mixture layer portion is formed by including a crushed pulp fiber material beaten to have a fiber length of 0.1 to 7 mm, and crushed tea dregs having a particle size of 0.7 to 3.8 mm in mixing content percentage of 14 to 43% by weight. |
| US08581016B2 |
Process for producing alkylated aromatic compound and process for producing phenol
The present invention provides an industrially practical process where a ketone and an aromatic compound are directly reacted to obtain a corresponding alkylated aromatic compound in a single reaction step. The process for producing an alkylated aromatic compound is characterized in that it comprises reacting an aromatic compound, a ketone and hydrogen in the presence of a solid acid substance and a catalyst composition comprising at least one metal selected from the group consisting of Co, Re, Ni and a platinum group metal. |
| US08581010B2 |
Formation of ethanol from methanol
A process is disclosed for the production of ethanol from methanol whereby methanol is condensed in the gas phase over a heterogeneous catalyst to produce ethanol and water. |
| US08581009B2 |
2-(alkylcarbonyloxy)-1, 1-difluoroethanesulfonic acid salt and method for producing the same
By using an organic base when a carboxylic acid bromodifluoroethyl ester is sulfinated by using a sulfinating agent, there is obtained 2-(alkylcarbonyloxy)-1,1-difluoroethanesulfinic acid ammonium salt. By oxidizing the 2-(alkylcarbonyloxy)-1,1-difluoroethanesulfinic acid ammonium salt, there is obtained 2-(alkylcarbonyloxy)-1,1-difluoroethanesulfonic acid ammonium salt. By using the 2-(alkylcarbonyloxy)-1,1-difluoroethanesulfonic acid ammonium salt as a raw material and exchanging it into an onium salt directly or through saponification/esterification, there can be obtained a 2-alkylcarbonyloxy-1,1-difluoroethanesulfonic acid onium salt. |
| US08581008B2 |
Process for preparing α,β-unsaturated C10-aldehydes
The invention relates to a method for continuously producing α,β-unsaturated C10-aldehydes from aliphatic C5-aldehydes, comprising the following steps: aldol-condensing aliphatic C5-aldehydes into α,β-unsaturated C10-aldehydes in the presence of an aqueous base in a tube reactor; phase separating the output of the tube reactor into an aqueous catalyst phase and an organic product phase; separating the organic product phase into α,β-unsaturated C10-aldehydes, aliphatic C5-aldehydes, and auxiliary products; discharging a part of the aqueous catalyst phase to remove the reaction water and supplementing said part with liquor solution and subsequently returning said part to the tube reactor. The task of the invention is to improve a method of said kind in a way such that it requires lower energy input. This is achieved in that the aliphatic C5-aldehydes and/or the α,β-unsaturated C10-aldehydes are dispersed in the aqueous base as drops, wherein the average Sauter diameter of the drops is between 0.2 mm and 2 mm. |
| US08581002B2 |
Process for working up diacetone acrylamide solutions for the preparation of pure diacetone acrylamide
Improved process for working up diacetone acrylamide solutions, obtained by reaction of acetone or diacetone alcohol with acrylonitrile and sulfuric acid and subsequent dilution and neutralization, in which a) the organic phase obtained subsequent to the neutralization, which comprises the crude diacetone acrylamide, is hydrolyzed by addition of an aqueous alkaline solution in order to remove acrylamide, then b) after phase separation has been carried out, the organic phase, which comprises the crude diacetone acrylamide, is neutralized by addition of an acid, and c) in succession, low-boiling-point byproducts are removed by distillation in the presence of one or more polymerization inhibitors, then t-butylacrylamide is removed by distillation and, finally, the diacetone acrylamide is isolated by product distillation, and d) the diacetone acrylamide thus obtained is converted into its final form. |
| US08581000B2 |
Process for preparing amide gellant compounds with aromatic end groups
Disclosed is a process for preparing a compound of the formula wherein R1 and R1′, R2 and R2′, and R3 are as defined herein, said process comprising (I) reacting a diacid of the formula HOOC—R2—COOH with a diamine of the formula H2N—R3—NH2 to form an acid-terminated oligoamide intermediate of the formula HOOC—R2—CONH—R3—HNCO—R2′—COOH; and (II) reacting the acid-terminated oligoamide intermediate with a monoalcohol of the formula R1—OH in the presence of a tin or organic titanate catalyst, in the absence of a coupling agent, and in the absence of a solvent to form the product. Also disclosed is a composition prepared by the process. |
| US08580998B2 |
Preparation of alkenes by mild thermolysis of sulfoxides
Embodiments of this disclosure, among others, encompass methods for generating alkenes under mild thermolytic conditions that can provide almost total conversion of a precursor compound to an alkene without isomerization or the need to chromatographically purify the final product By selectively blocking the amino and carboxy groups of the derivatized amino acid, the methods of the disclosure provide for the synthesis of a peptide having the vinylglycine moiety at either the carboxy or the amino terminus of the peptide The mild conditions for the thermolytic removal of an o-NO2-phenyl substituted aryl group ensure that there is minimal if any damage to thermally sensitive conjugates such as a peptide bearing the vinylglycine The methods of the present disclosure have practical applications for the preparation of unsaturated compounds under mild, thermolytic conditions. |
| US08580993B2 |
Amino vinylsilane precursors for stressed SiN films
The present invention is a method to increase the intrinsic compressive stress in plasma enhanced chemical vapor deposition (PECVD) silicon nitride (SiN) and silicon carbonitride (SiCN) thin films, comprising depositing the film from an amino vinylsilane-based precursor. More specifically the present invention uses the amino vinylsilane-based precursor selected from the formula: [RR1N]xSiR3y(R2)z, where x+y+z=4, x=1-3, y=0-2, and z=1-3; R, R1 and R3 can be hydrogen, C1 to C10 alkane, alkene, or C4 to C12 aromatic; each R2 is a vinyl, allyl or vinyl-containing functional group. |
| US08580986B2 |
Process for the production of fatty acid alkyl esters
Disclosed is an improved process for the production of fatty acid lower alkyl esters according to formula (I) R1CO—OR2 (I) in which R1CO represents a linear or branched acyl moiety having from about 6 to about 22 carbon atoms and 0 to 6 double bonds and wherein R2 is a linear or branched alkyl moiety having 1 to 6 carbon atoms, by transesterification of triglycerides or fatty acid esters using C1-C6 aliphatic alcohols, which includes the steps of (a) providing an aqueous mixture of aliphatic C1-C6 alcohol by fermenting in a first reactor a carbon source comprising carbohydrates and/or glycerol produce a fermentation broth comprising said aliphatic C1-C6 alcohol, (b) providing in a second reactor a triglyceride and/or an ester of a fatty acid, together with a biocatalyst capable of effecting a transesterification reaction, (c) transferring said aqueous aliphatic C1-C6 alcohol mixture obtained from said first reactor into said second reactor to provide a two-phase system, and (d) effecting the transesterification reaction to produce said fatty acid lower alkyl ester and a glycerol- or alcohol-containing aqueous phase. The products thus obtained are particularly useful as components of the fuel known as biodiesel. |
| US08580984B2 |
Esters of secondary hydroxy fatty acid oligomers and preparation thereof
Prepare an ester of a secondary hydroxy fatty acid oligomer by first partially homopolymerizing a hydroxylated fatty acid compound, reacting the partially homopolymerized hydroxylated fatty acid compound with an alcohol to form an intermediate product, and capping the intermediate product with an acid, acid anhydride or ester. The ester of a secondary hydroxy fatty acid oligomer may be represented as follows: (3) where R is an alkyl group that contains from six to twelve carbon atoms, R1 is hydrogen or a methyl radical, x is an integer within a range of from 8 to 12, n is an integer between 1 and 20, R2 is an alkyl group that contains from one carbon atom to twenty carbon atoms and R3 is an alkyl group that contains from one carbon atom to twelve carbon atoms. |
| US08580981B2 |
Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
The present invention relates to a process for the preparation of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate as well as novel intermediates for use in said process. (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate is particularly useful as an HIV protease inhibitor. |
| US08580977B2 |
Tautomycetin and tautomycetin analog biosynthesis
The present invention relates to the biosynthetic gene cluster for tautomycetin (TTN) produces tautomycetin. Also provided are engineered micro-organisms for the production of TTN and analogs thereof, as well as methods of screening for compounds for activity. |
| US08580976B2 |
Process for preparing A 2-substituted benzofuran-3-yl borate ester
The invention relates to a process for preparing a stable 2-substituted benzofuran-3-yl borate ester corresponding to the formula: said process comprising contacting 3-bromo-2-substituted-benzofuran corresponding to the formula: with an C1-4 alkyllithium at a temperature less than −60° C. to form 3-lithio-2-substititued-benzofuran, contacting the 3-lithio-2-substituted- benzofuran at a temperature less than −60° C. with an borate ester corresponding to the formula: and recovering the resulting borate ester product, wherein, RW' is C1-4 alkyl; Rx is C1-10 hydrocarbyl or halohydrocarbyl; and RY independently each occurrence is C1-10 hydrocarbyl, halohydrocarbyl or trialkylsilylhydrocarbyl or 2 RY groups together are a divalent hydrocarbylene of up to 20 carbons. |
| US08580973B2 |
Process for the preparation of 2,2-difluoroethylamine
A process for the preparation of 2,2-difluoroethylamine, comprising the reaction of 2,2-difluoro-1-chloroethane with an imide of the formula (II) in the presence of an acid scavenger, to give a compound of the formula (III) in which, in the compounds of the formulae (II) and (III), R1 and R2 are, each independently of one another, hydrogen or C1-C6-alkyl or R1 and R2 form, together with the carbon atoms to which they are bonded, a six-membered aromatic ring which is optionally substituted; and the cleavage of 2,2-difluoroethylamine by reaction of the compound of the formula (III) with acid, base or hydrazine. |
| US08580971B2 |
Alkyl-analide producing method
New pyrazolylcarboxanilides of the formula (I) in which R and R1 have the meanings given in the description, a plurality of processes for the preparation of these substances and their use for controlling undesired microorganisms, and novel intermediates and their preparation. |
| US08580968B2 |
Benzothiazole and benzooxazole derivatives and methods of use
Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds. |
| US08580963B2 |
Method for the manufacturing of naltrexone
The present invention relates to an improved process for producing naltrexone[17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-morphinan-6-one] from noroxymorphone[4,5-α-epoxy-3,14-dihydroxy-morphinan-6-one] by alkylation with a cyclopropylmethyl halide. |
| US08580960B2 |
Process for synthesis of phenoxy diaminopyrimidine derivatives
A method for preparing a compound of formula k or a salt or solvate thereof, wherein R1 is as defined herein, the method comprising treating a compound of formula j or a salt or solvate thereof, with ammonia, to form the compound of formula k. |
| US08580959B2 |
Azolotriazinone melanin concentrating hormone receptor-1 antagonists
The present application provides compounds that are useful as MCHR1 antagonists, especially for the treatment of obesity, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I wherein the variables are defined herein. |
| US08580958B1 |
Two-photon absorbing polyhydroxy diphenylamino-dialkylfluorene-1,3,5-triazine molecules
Provided are novel 2PA-active monomers of the formula: wherein Y═H, acrylic or methacrylic moiety; R is a linear or branched alkyl group, —CmH2m+1, where m=1-6 or an alkylether group, —(CH2CH2O)pMe, where p=1-5. The number of R′—(OH)x groups, attached to the phenyl rings of the triarylamine moiety either in a para or a meta position, could be 3 or 6 per molecule, or mixtures of molecules containing 3, 4, 5, 6 in various ratios and wherein x=1, 2, or 3. R′ is a linear or branched alkyl group such as —CmH2m, where m=1-6, i.e. linear —(CH2)m, where m=2-6, or branched alkyl group such as —CH2CH(R″)—, where R″═—(CH2)lCH3, where l=2-6. |
| US08580957B2 |
Thetrahydroquinolines derivatives as bromodomain inhibitors
Tetrahydroquinoline compounds of formula (I) or a salt thereof, pharmaceutical compositions containing such compounds and their use in therapy, in particular in the treatment of diseases or conditions for which a bromodomain inhibitor is indicted. |
| US08580956B2 |
Gamma secretase modulators
In its many embodiments, the present invention provides a novel class of heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions. |
| US08580955B2 |
Purification method and production method for cellobiose
The present invention provides a method for purifying cellobiose which comprises the steps of (A) preparing a cellobiose-containing sugar solution; (B) increasing the rate of cellobiose present in the sugar solution relative to the total saccharides present therein up to at least 50% by mass; and (C) crystallizing cellobiose; and a method for preparing cellobiose having a high content of the α-anomer thereof which comprises the step of drying a cellobiose-containing sugar solution having a rate of cellobiose of at least 90% by mass relative to the total saccharides present therein while maintaining the sugar solution at a temperature ranging from 80 to 95° C. These methods of the present invention permit the economical preparation of cellobiose having considerably improved purity and recovery rate, without using any complicated process. Moreover, the present invention also permits the preparation of cellobiose highly soluble in water. |
| US08580953B2 |
Water-absorbing polysaccharide and method for producing the same
The present invention relates to a process for producing a water-absorbent polysaccharide including the process steps of bringing into contact an uncrosslinked polysaccharide with a polyphosphate or a polyphosphoric acid as crosslinking agent in the presence of water to form a polysaccharide gel and crosslinking the polysaccharide gel. The invention further relates to a water-absorbent polysaccharide obtainable by this process, a water-absorbent polysaccharide, a composite, a process for producing a composite, a composite produced by this process, the use of the water-absorbent polysaccharides or of the composites as well as the use of polyphosphates. |
| US08580949B2 |
Enzymatic synthesis of carba-NAD
The disclosure concerns the enzymatic synthesis of stable analogues of nicotinamide adenine dinucleotide NAD/NADH and nicotinamide adenine dinucleotide phosphate NADP/NADPH, the so-called “carba-NADs”, i.e. analogues of NAD/NADH or NADP/NADPH, respectively, comprising a carbacyclic sugar instead of ribose. |
| US08580948B2 |
Modulation of forkhead box O1A expression
Antisense compounds, compositions and methods are provided for modulating the expression of forkhead box O1A. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding forkhead box O1A. Methods of using these compounds for modulation of forkhead box O1A expression and for treatment of diseases associated with expression of forkhead box O1A are provided, in particular, for methods of treating diabetes. |
| US08580947B2 |
Pharmaceutical composition for preventing, stabilising and/or inhibiting blood and lymph vascularization
A pharmaceutical composition including as active agent, an antisens oligonucleotide having the sequence SEQ ID NO: 1, wherein the antisens oligonucleotide is in a concentration from about 0.40 mg/ml to about 2 mg/ml and the use thereof for preventing, stabilizing and/or inhibiting blood and lymph vascularization. |
| US08580946B2 |
Multi-conjugate of siRNA and preparing method thereof
The present invention relates to a multi-conjugate of small interfering RNA (siRNA) and a preparing method of the same, more precisely a multi-conjugate of siRNA prepared by direct binding of double stranded sense/antisense siRNA monomers or indirect covalent bonding mediated by a cross-linking agent or a polymer, and a preparing method of the same. The preparing method of a siRNA multi-conjugate of the present invention is characterized by simple and efficient reaction and thereby the prepared siRNA multi-conjugate of the present invention has high molecular weight multiple times the conventional siRNA, so that it has high negative charge density, suggesting that it has excellent ionic interaction with a cationic gene carrier and high gene delivery efficiency. |
| US08580941B2 |
Epididymal lipocalin gene and uses thereof
Isolated nucleic acids comprising a lipocalin gene promoter region, isolated nucleic acids comprising a human lipocalin gene, isolated nucleic acids encoding a lipocalin polypeptide, isolated lipocalin polypeptides, and uses thereof. The disclosed lipocalin nucleic acids and polypeptides can be used to generate a mouse model of male infertility, for drug discovery screens, and for therapeutic treatment of fertility-related conditions. |
| US08580939B2 |
Engineered Listeria and methods of use thereof
The invention provides a bacterium containing a polynucleotide comprising a nucleic acid encoding a heterologous antigen, as well as fusion protein partners. Also provided are vectors for mediating site-specific recombination and vectors comprising removable antibiotic resistance genes. |
| US08580938B2 |
Engineered anti-TSLP antibody
The invention relates to binding compounds that specifically bind to human TSLP, as well as uses thereof, e.g., in the treatment of inflammatory disorders. |
| US08580936B2 |
Polynucleotides encoding FGFR1-IIIc ECD fusion proteins
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their stability. These fusion proteins inhibit the growth and viability of cancer cells in vitro and in vivo. The combination of the relatively high affinity of these receptors for their ligand FGFs and the demonstrated ability of these decoy receptors to inhibit tumor growth is an indication of the clinical value of the compositions and methods provided herein. |
| US08580933B2 |
Variable tangential flow filtration
The current invention reports a method for concentrating an immunoglobulin solution by tangential flow filtration wherein the transmembrane pressure and the cross-flow are variable. |
| US08580930B2 |
Hepatocyte growth factor (HGF) binding proteins
The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors. |
| US08580929B2 |
DNA sequence encoding a retinoic acid regulated protein
The present invention concerns a novel retinoic acid regulated gene whose expression product displays useful morphogenic/mitogenic properties. The present invention further concerns an isolated nucleic acid of SEQ ID NO:1 encoding a retinoic acid regulated expression product having an amino acid sequence of SEQ ID NO:2. |
| US08580927B2 |
Engineered antibody constant domain molecules
Described herein are engineered antibody constant domain molecules, such as CH2 or CH3 domain molecules, comprising at least one mutation, or comprising at least one complementarity determining region (CDR), or a functional fragment thereof, engrafted in a loop region of the CH2 domain. The CH2 domain molecules described herein are small, stable, soluble, exhibit little to no toxicity and are capable of binding antigen. |
| US08580926B2 |
Gene and protein expression profiles associated with the therapeutic efficacy of irinotecan
The present invention includes gene and protein expression profiles indicative of whether a cancer patient is likely to respond to treatment with irinotecan. By identifying such responsiveness, a treatment provider may determine in advance those patients who would benefit from such treatment, as well as identify alternative therapies for non-responders. The present invention further provide methods of using the gene and/or protein expression profiles and assays for identifying the presence of a gene and/or protein expression profile in a patient sample. |
| US08580925B2 |
Method for examining carcinoma and adenoma
[PROBLEMS] To provide examination methods and reagents able to detect efficiently cancer patients and patients at high risk of cancer.[MEANS FOR SOLVING PROBLEMS] Significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, between non-carcinoma tissues and carcinoma tissues or adenoma tissues were discovered. The discovery is evidently applicable to detect carcinomas and adenomas (except colorectal carcinomas and colorectal adenomas) specifically by assaying a certain range of GlcNAc-6-sulfated sugar residue groups in tissues of patients and in fecal samples. Examination of carcinomas and adenomas is possible by the use of antibodies reacting specifically with GlcNAc-6-sulfated sugar residues specifically synthesized by enzymes present in carcinoma and adenoma tissues. |
| US08580916B2 |
Stable solution of the polymer prepared from N,O-heterocycles and its preparation method and use
A stable solution of the polymer prepared from N,O-heterocyclic compound and its preparing method are provided, wherein the stable solution is prepared by making the N,O-heterocyclic compound of formulae I or II carry out a ring-opening polymerization: wherein R1 to R3, W1, W2, m, n, p and q are as defined in the specification. The stable solution can be used as a hardener for curing epoxy resin. |
| US08580915B2 |
Process for preparing stable photoresist compositions
A micro electromechanical system having incorporated therein a composition of matter consisting of a stable solution containing a polymer derived from a solution of a polymer containing trace metals, the derived method comprising the steps of: (a) providing a polymer solution containing a polymer, a first solvent and trace metals; (b) passing said polymer solution through an acidic cation ion exchange material to remove said trace metals therefrom and thereby forming a polymer solution containing free acid radicals; (c) precipitating said polymer from said polymer solution of step b by contacting with a second solvent wherein the polymer is substantially insoluble therein; (d) filtering said solution and said second solvent to thereby form a solid polymer cake; (e) contacting said cake from step d with sufficient quantities of additional said second solvent in order to remove free acid radicals therefrom; (f) removing any residual first and second solvents from said polymer to form said stable polymer. |
| US08580911B2 |
Polycarbonate block copolymers
The disclosure pertains to amphiphilic block copolymers comprising an aliphatic polycarbonate chain coupled to a hydrophilic polymer. Such amphiphilic polymers may have the formula A-L-B, where A- is a polycarbonate or polyethercarbonate chain having from about 3 to about 500 repeating units, L is a linker moiety and —B is a hydrophilic oligomer having from about 4 to about 200 repeating units. Provided copolymers are useful as surfactants capable of emulsifying aqueous solutions and supercritical carbon dioxide. Provided copolymers also have utility as additives for use in enhanced oil recovery methods. |
| US08580909B2 |
Hotmelt process for producing a chemically crosslinked polyurethane film
Process for producing a chemically crosslinked polyurethane film, comprising the steps of: A) chemically reacting a mixture comprising two or more polyols with one or more polyisocyanates, at least one of the polyols or at least one of the polyisocyanates comprising molecules having a functionality of three or more, to form hydroxyl-functionalized polyurethane hotmelt prepolymer, B) reacting the hydroxyl-functionalized polyurethane hotmelt prepolymer with one or more polyisocyanates in a continuously operating mixing assembly, C) coating the melt emerging from the mixing assembly onto an incoming web-form material or between two incoming web-form materials, in the course of which the reaction started in step B) continues. |
| US08580907B2 |
Insulating film material, multilayer wiring board and production method thereof, and semiconductor device and production method thereof
An insulating film material, which contains a polycarbosilane compound expressed by the following structural formula 1: where R1 may be the same or different to each other in the unit repeated “n” times, and each represents C1-4 hydrocarbon or aromatic hydrocarbon; R2 may be the same or different to each other in the unit repeated “n” times, and each represents C1-4 hydrocarbon or aromatic hydrocarbon; n is an integer of 5 to 5,000. |
| US08580904B2 |
Silicone monomer
The invention provides a silicone monomer which is suitable for the manufacture of ophthalmic devices, such as contact lenses, intraocular lenses, and keratoprosthesis, a monomer composition containing the monomer, and a polymer which fulfills both surface hydrophilicity and oxygen permeability at the same time. The silicone monomer of the present invention is represented by the formula (1a) or (1b): (X: a monovalent C2 to C6 organic group having one or more —OH and optionally one O or N in its main chain; Z1 to Z9: a C1 to C4 alkyl group; n: 1 to 3; a and b: 0 or 1). |
| US08580902B2 |
Catalyst system, process for olefin polymerization, and polymer compositions produced therefrom
Provided are catalyst systems, processes for polymerizing one or more olefins, polymers resulting therefrom, and articles prepared from such polymers. The processes comprise contacting under polymerization conditions one or more olefin monomers, preferably propylene, with a catalyst system comprising a transition metal compound and an activator of the formula (1) or (2) as described herein. The polymer compositions described herein exhibit advantageously narrow composition distributions and high melting points in comparison to conventional polymers having the same comonomer content. The polymers described herein exhibit improved properties, e.g., pellet stability, impact properties, heat seal properties, and structural integrity in film and fabricated parts applications. |
| US08580901B2 |
Crosslinkable coating compositions containing polyurethane
An aqueous crosslinkable coating composition that includes a PU polymer and a vinyl polymer bearing carbonyl groups (i.e., a carbonyl-functional vinyl polymer) and/or latex polymer. The composition also preferably includes carbonyl-reactive amine and/or hydrazine functional groups. |
| US08580900B2 |
Thermoplastic amphiphilic co-networks
The present invention relates generally to thermoplastic amphiphilic networks and/or co-networks. In one embodiment, the present invention relates to thermoplastic (TP) amphiphilic co-networks (APCNs) and the preparation of membranes from such APCNs. In another embodiment, the present invention relates to an amphiphilic network comprising at least one hydrophilic polymer-derived portion, at least one hydrophobic polymer-derived portion and at least one thermoplastic polymer-derived portion. In still another embodiment, the present invention relates to thermoplastic amphiphilic co-networks prepared by combining the chemistries of APCNs and polyurethanes (PUs) and to the preparation of membranes therefrom. |
| US08580895B2 |
Caps and closures
This invention discloses caps and closures produced by injection molding with a bimodal high density polyethylene (HDPE) resin comprising a low molecular weight, high density polyethylene fraction substantially free of comonomer and a high molecular weight, low density polyethylene fraction, having a molecular weight distribution of at least 3.5, preferably greater than 4.0, prepared in two reactors connected in series in the presence of a metallocene-containing catalyst system, wherein the metallocene comprises a bisindenyl or a bis-tetrahydrogenated-indenyl component. |
| US08580891B2 |
Silicone acrylic hybrid polymer-based adhesives
Silicone acrylic hybrid compositions prepared by reacting together silicone polymers, silicone resins, and silyl containing acrylic polymers are useful in adhesive compositions that find use in skin contact applications. |
| US08580890B2 |
Heterophasic propylene copolymer with improved properties for injection molding applications
The present invention concerns a heterophasic propylene copolymer of high melt flow for injection molding, which comprise a propylene polymer matrix and a rubber. The heterophasic propylene copolymers of the present invention are characterized by a high viscosity of the rubber phase and a well-defined ratio of the intrinsic viscosities of the rubber phase and the propylene polymer matrix, thus resulting in improved mechanical properties. The present invention further relates to a process for the production of such heterophasic propylene copolymers, their use and articles produced with them. |
| US08580886B2 |
Method for the preparation and use of bis (alkoxysilylorgano)-dicarboxylates
A method for preparing a bis(alkoxysilylorgano)dicarboxylate includes reacting a haloorganoalkoxysilane, a dimetal salt of a dicarboxyl functional compound, and a phase transfer catalyst. A quaternary iminium compound of a polyaza, polycycloalkene is useful as the phase transfer catalyst. The product may be a bis(alkoxysilylalkyl)fumarate, which is useful as a coupling agent in rubber compositions for tire applications. |
| US08580882B1 |
Glove-forming solution
A glove-forming liquid solution that when rubbed on a user's hand forms a solid glove around the hand, the solution features a percentage latex, a percentage water, a percentage aloe-barbadensis leaf juice, a percentage glycerin, a percentage stearic acid, a percentage glyceryl, a percentage cetyl alcohol, a percentage safflower seed oil, and a percentage lanolin. |
| US08580875B2 |
Acrylic emulsion polymers for removable pressure sensitive adhesive applications
An improved aqueous acrylic emulsion pressure sensitive adhesive (PSA) composition of improved sheer strength includes an aqueous acrylic emulsion including at least one hydrophobic monomer, at least one hydrophilic monomer, and at least one hydrogen bonding monomer; and a peel control additive. The PSA composition is substantially devoid of phosphate-based surfactants. |
| US08580869B2 |
Seamless model and method of making a seamless model
The present disclosure relates to a seamless model free of bond lines made by a method which includes the steps of providing a substructure having an exposed outer surface, applying a modeling paste to the outer surface of the substructure in the form of a continuous layer, curing the continuous layer of applied modeling paste, and machining said cured layer of modeling paste to the desired contour to form the seamless model. The modeling paste may be a mechanically frothed syntactic foam prepared by injecting inert gas with mechanical stirring into either a formed froth-forming polyurethane or epoxy composition containing microballoons. |
| US08580866B2 |
Dry powder polymer finish
A dry powder composition for preparing a dry form of an acrylic finish is provided. The dry powder composition includes: calcium carbonate filler, coalescing aid, pH adjuster, and an acrylic-based re-dispersible polymer in powder form. In various embodiments, aggregate, silica sand, titanium dioxide, cellulose thickener, biocide, clay, cellulose fiber, mica filler, and/or defoamer are added. The dry powder composition can further comprise a hydrophobic agent. The dry powder can be mixed with a volume of water to produce a wet coating for application to a substrate. |
| US08580861B2 |
Chemical composition for skin care formulations
The present invention provides preservative compositions suitable for replacing, partially or in totality, conventional preservatives in skin care and hygiene cosmetic or pharmaceutical products. The preservative formulations include an organic carboxylic acid present in a concentration from about 0.01 to about 30 wt./wt. % of the formulation, an alcohol present in a concentration from about 0.01 to about 60 wt./wt. % of the formulation. The formulations include an inorganic salt present in a concentration from about 0.01 to about 80 wt./wt. % of the formulation, and a chelating agent present in a concentration from about 0.01 to about 20 wt./wt. % of the formulation. |
| US08580860B2 |
Foamable alcoholic composition
A foamable composition includes greater than about 40 weight percent of an alcohol, based upon the total weight of the alcoholic composition, and a foaming surfactant selected from gemini surfactants, sulfuric acid esters, di-esters, C10-34 fatty alcohols, polyquaternium polymers, and combinations thereof. |
| US08580857B2 |
Methods and compositions to determine the chemosensitizing dose of suramin used in combination therapy
A method for determining a therapeutically effective amount of suramin for administering to a patient, who is to receive a cytotoxic agent, which comprises the steps of determining the circulating suramin concentration in the patient; administering suramin, if required, to establish a low circulating concentration of suramin in the patient of below about 200 μM; and administering the chemotherapeutic agent to the patient when the low circulating concentration of suramin is present in the patient. Conveniently a nomogram can be constructed for use in clinical settings with the suramin. |
| US08580852B2 |
2-oxamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudopeptides
The disclosure provides a series of 2-oxoamides based on dipeptides and pseudodipeptides, which were synthesized and their activities toward two human intracellular phospholipases A2 (GIVA CPLA 2 and GVIA 1PLA 2) and one human secretory phospholipase A2 (GV sPLA 2) were evaluated. Derivatives containing a free carboxyl group are selective GIVA cPLA 2 inhibitors. A derivative based on the ethyl ester of an ether pseudodipeptide is the first 2-oxoamide, which preferentially inhibits GVIA iPLA 2. The effect of 2-oxoamides on the generation of arachidonic acid from RAW 264.7 macrophages was also studied. It was found that selective GIVA cPLA 2 inhibitors preferentially inhibited cellular arachidonic acid release; in which one pseudodipeptide gave an IC50 value of 2 μM. |
| US08580843B2 |
Use of diindolylmethane (DIM) compounds and derivatives as neuroprotective agents
Presented herein are diindolylmethane derivative compounds useful for the prevention and or treatment of neurological conditions, including neurological conditions related to neuroinflammation. One such neurological condition is Parkinson's disease. |
| US08580838B2 |
5-membered heterocycle-based p38 kinase inhibitors
Provided are 5-membered heterocycle-based p38 kinase inhibitors. Further provided are pyrazole and imidazole-based p38 kinase, including p38α, and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders. |
| US08580837B2 |
Parasiticidal formulation
The present invention provides a parasiticidal formulation comprising: Fipronil, or a veterinarily acceptable derivative thereof; at least one C1-C6 alcohol co-solvent, wherein the total amount of C1-C6 alcohol is up to 8% by weight of the formulation; at least one organic solvent which is not the C1-C6 alcohol co-solvent; and at least one crystallization inhibitor, wherein the total amount of crystallization inhibitor is from 2 to 20% by weight of the formulation. The formulations of the invention have higher flash points than known parasiticidal formulations comprising Fipronil and therefore provide safer formulations for use in the home, storage, manufacture and distribution. |
| US08580836B2 |
Plant disease control composition and method of controlling plant disease
A plant disease control composition comprising a carboxamide compound represented by formula (I) whose enantiomer ratio R form/S form of the carboxamide compound is 80/20 or more has an excellent plant disease controlling activity. |
| US08580833B2 |
Substituted imidazole derivatives and methods of use thereof
The present invention provides imidazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment of RAGE-mediated diseases such as Alzheimer's Disease. The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use the such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases. |
| US08580830B2 |
Non-mucoadhesive film dosage forms
Orally disintegrating film dosage forms for delivering active pharmaceutical agents, methods of formulating the dosage forms to retard absorption through the oral mucosa, and methods of using the dosage forms for the treatment of various medical conditions are provided. |
| US08580829B2 |
Oxadiazole inhibitors of leukotriene production
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes. |
| US08580827B2 |
Anti-Francisella agents
A series of celecoxib derivatives defined by Formula I: were prepared and evaluated for their ability to inhibit the gram-negative bacteria Francisella tularensis. Pharmaceutical compositions including celecoxib derivatives and their use in methods for treating or preventing infection by Francisella tularensis in a subject are described. |
| US08580823B2 |
Piperidine renin inhibitors
The present invention is directed to aspartic protease inhibitors represented by the following structural formula: or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the aspartic protease inhibitors of Structural Formula (I).Methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using these aspartic protease inhibitors are also disclosed. |
| US08580819B2 |
Deuterated N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof
The subject invention provides deuterated N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, its salts and uses. |
| US08580817B2 |
1-(1-OXO-1,2,3,4-tetrahydroisoquinolin-7-YL)urea derivatives as N-formyl peptide receptor like-1 (FPRL-1) receptor modulators
The present invention relates to novel 1-(1-Oxo-1,2,3,4-tetrahydroisoquinolin-7-yl)urea derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor. |
| US08580816B2 |
Carboxylic acid derivatives having an oxazolo[5,4-b]pyridine ring
The invention therefore relates to compounds of the formula I in which X, Y, R1, R2 and R3 have the given meanings. The compounds of the formula I are suitable, for example, for wound healing. |
| US08580815B2 |
Derivatives of azaindoles as inhibitors of protein kinases ABL and SRC
The present invention relates to compounds of general formula I and use thereof as inhibitors of protein kinases AbI and Src and the method of production thereof. The present invention also relates to pharmaceutical compositions and medicinal products comprising these compounds. |
| US08580810B2 |
Compounds and formulations suitable for radical scavenging
The present invention relates to compositions and methods of using free radical scavengers with reduced 1O2 generation. In certain embodiments, these compositions and methods of use relate to fullerene-derived ketolactams and fullerene-derived keto lactam derivatives, fullerene derivatives, and/or fullerenes. In yet other embodiments, the invention relates to cosmetic or dermatological compositions comprising said free radical scavengers with reduced 1O2 generation. |
| US08580809B2 |
Filamin A-binding anti-inflammatory analgesic
A compound, its pharmaceutically acceptable salt, a composition containing the same and method of treatment that can provide analgesia and/or reduce inflammation are disclosed. A contemplated compound has a structure that corresponds to Formula A, wherein G, W, Q, Z, D, E, F, K, Y, d, e, f, k, n, m, and circle B and all R groups are defined within. |
| US08580808B2 |
Filamin A-binding anti-inflammatory analgesic
A compound, its pharmaceutically acceptable salt, a composition containing the same and method of treatment that can provide analgesia and/or reduce inflammation are disclosed. A contemplated compound has a structure that corresponds to Formula A, wherein G, W, Q, Z, D, E, F, K, Y, d, e, f, k, n, m, and circle B and all R groups are defined within. |
| US08580807B2 |
Bicyclic piperidine and piperazine derivatives as GPCR modulators for the treatment of obesity, diabetes and other metabolic disorders
The present invention relates to Bicyclic Piperidine and piperazine Derivatives, compositions comprising a Bicyclic Piperidine and piperazine Derivative, and methods of using the Bicyclic Piperidine and piperazine Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a GPCR in a patient. |
| US08580806B2 |
Salts of 4-methyl N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide are prepared by various processes. |
| US08580805B2 |
Pyrimidine carboxamide derivatives
The invention relates to a compound of the formula wherein the substituents are as defined herein, and a pharmaceutically acceptable salt of the compound of formula (1). The compounds of formula (1) and their salts possess inflammation inhibiting properties and are therefore useful in the treatment and prevention of conditions related to inflammations such as inflammatory joint diseases. The compounds of formula (1) are also useful for the treatment of diseases where chronic inflammation is the underlying cause. This application relates to compounds of formula (1), methods for their preparation, pharmaceutical compositions comprising these compounds, and their use for the preparation of a medicament for the treatment of humans and animals. |
| US08580804B2 |
Compound having hetero ring skeleton, and process for producing optically active compound using the aforementioned compound as asymmetric catalyst
The invention provides a compound having a heterocyclic skeleton of formula (I): wherein the indicated moieties are as described in the specification, as well as a tautomer thereof or a salt thereof. The compound is useful as a catalyst for an asymmetric synthesis. |
| US08580801B2 |
Phosphodiesterase inhibitor treatment
Methods and compositions are disclosed for the treatment of diseases or conditions produced by or associated with low cyclic nucleotide levels. The compositions comprise phosphodiesterase inhibitors and are formulated for intranasal and pulmonary administration. |
| US08580792B2 |
Inhibitor compounds and cancer treatment methods
A synergistically effective combination of an anti-cancer agent and a therapeutic compound, such as an mTOR-Rictor complex inhibitor, a Serine 473 phosphorylation inhibitor, an AKT2 inhibitor, or a combination thereof, for use in the treatment of cancer, and methods and uses thereof. Also included are methods and uses of a thiosemicarbazone for treating a cancer in a mammal in need thereof characterized by over-expression of RAS, by an EGFR mutation, and/or by over-expression of AKT2. |
| US08580790B2 |
(Heterocycle/condensed piperidine)-(piperazinyl)-1-alkanone or (heterocycle/condensed pyrrolidine)-(piperazinyl)-1-alkanone derivatives and use thereof as p75 inhibitors
The disclosure relates to (heterocycle-fused piperidine)-(piperazinyl)-1-alkanone derivatives and (heterocycle-fused pyrrolidine)-(piperazinyl)-1-alkanone derivatives of formula (I): wherein A, W, R2 and n are as defined in the disclosure, to the method of preparation thereof and the therapeutic use thereof. |
| US08580789B2 |
Treating glaucoma
Provided herein are methods of protecting all or a portion of the optic nerve fiber layer within the optic nerve/lamina cribrosa (ONLC) complex in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's peripapillary sclera, thereby stiffening the individual's peripapillary sclera and protecting all or a portion of the optic nerve fiber layer within the ONLC of the individual. In a particular embodiment, the invention is directed to methods of treating glaucoma in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's peripapillary sclera, thereby stiffening the individual's peripapillary sclera and treating the glaucoma in the individual. In yet another embodiment, the invention is directed to methods of treating glaucomatous optic neuropathy in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's peripapillary sclera, thereby stiffening the individual's peripapillary sclera and treating the glaucomatous optic neuropathy in the individual. The method can further comprise administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's lamina cribrosa (LC). |
| US08580785B2 |
Insecticides
Compounds of formula (I), wherein the substituents are as defined in claim (1), and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula (I) can be used as agrochemical active ingredients and can be prepared in a manner known per se. |
| US08580784B2 |
Method for treating a disease related to the glucocorticoid receptor
A method for preventing or treating a disease related to the glucocorticoid receptor involving administering a pharmacologically effective amount of a 1,2-dihydroquinoline compound. |
| US08580783B2 |
[1,2,4]triazolo [1,5-c]pyrimidine derivatives as Hsp90 modulators
The present invention relates to [1,2,4]triazolo[1,5-c]pyrimidine derivatives of formula (I) which inhibit the activity of Heat Shock Protein Hsp90. The compounds of the invention are therefore useful in treating proliferative diseases such as cancer and neurodegenerative diseases. The present invention also provides processes for preparing these compounds, methods of treating diseases and the pharmaceutical compositions comprising these compounds. |
| US08580782B2 |
Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or compositions. |
| US08580779B2 |
1,2-bis-sulfonamide derivatives as chemokine receptor modulators
The present invention relates to novel bis-sulfonamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors. |
| US08580770B2 |
Method of treating actinic keratosis and basal cell carcinoma
A method for treating actinic keratosis or basal cell carcinoma. A person's skin is inspected to identify areas that exhibit lesions indicating actinic keratosis or basel cell carcinoma. If such areas are found, a treating composition is applied to the skin in that area. The treating composition may include avobenzone, octocrylene, octyl salicylate, and oxybenzone, and optionally may additionally include SD alcohol 40, C12-15 alkyl benzoate, acrylates, octylacrylamide copolymer, hydroxypropyl cellulose, PEG-40 sorbitan peroleate, tocopherol, and aloe barbadensis extract. The skin is monitored regularly to determine whether the skin lesions remain, and the treating composition is applied several times daily for a period of at least two months until the area is substantially free of the lesions. |
| US08580769B2 |
Treatment of obesity, metabolic syndrome, and diabetes with protein kinase C inhibitors
Disclosed herein are methods for treating obesity, metabolic syndrome, diabetes, or a combination of these conditions. The methods include selecting a subject with obesity, metabolic syndrome, or diabetes and administering to the subject a therapeutically effective amount of a composition comprising a compound that specifically inhibits hepatic protein kinase C (PKC)-ι, thereby treating the obesity, metabolic syndrome, or diabetes in the subject. In some embodiments the compound that specifically inhibits hepatic PKC-ι includes a thio-gold compound (such as aurothiomalate, aurothioglucose, and auranofin) or a derivative thereof, or a pharmaceutically acceptable salt thereof. In other embodiments, the compound that specifically inhibits hepatic PKC-ι includes 1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl]-[1R-(1α,2β,3β,4α)] (ICAPP) or a derivative thereof, or a pharmaceutically acceptable salt thereof. |
| US08580767B2 |
Oxazolidinone containing dimer compounds, compositions and methods to make and use
Dosage forms or pharmaceutical compositions comprise a compound having the structure of Formula IV: wherein n is a non-negative integer; wherein each Z is an oxazolidinone-containing moiety having antibiotic activity in vivo upon cleaving, wherein M is independently OR1 or NR1R2; wherein R1 and R2 are independently selected from the group consisting of H, an optionally-substituted hydrocarbyl residue or a pharmaceutically acceptable cation; wherein the compound in the dosage form or a pharmaceutical composition is present in an amount effective for treating or preventing an antibacterial infection in a mammalian subject. Methods of preparing and using these dosage forms or pharmaceutical compositions are also disclosed. |
| US08580764B2 |
Combinational compositions and methods for treatment of cancer
The present invention provides methods of treating a cell proliferative disorder, such as lung cancer and breast cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or a pyrroloquinolinyl-pyrrolidine-2,5-dione compound, such as (−)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione, in combination with a therapeutically effective amount of a second anti-proliferative agent, such as gemcitabine. |
| US08580763B2 |
2, 6-dinitrogen-containing substituted purine derivatives, the preparation and uses thereof
The present invention provides 2,6-dinitrogen-containing substituted purine compounds of formula (A) or salts or solvates thereof or the solvates of salts thereof, as well as pharmaceutical compositions containing such compounds. The compounds of the present invention have the characteristics of lower toxicity, broad anticancer spectrum, higher anticancer activity, good stability and the like. The compounds are useful for the manufacture of an antitumor medicament. The present invention also provides a process for preparing these compounds. |
| US08580761B2 |
Bispecific antisense oligonucleotides that inhibit IGFBP-2 and IGFBP-5 and methods of using same
Bispecific antisense oligonucleotides which consist essentially of a sequence of bases that is complementary to portions of both the gene encoding human IGFBP-2 and the gene encoding human IGFBP-5 are useful in as antisense therapeutics in the treatment of endocrine-regulated cancers. |
| US08580759B2 |
Anti-hepatitis C virus composition
The present invention provides an anti-hepatitis C virus composition that includes a substance that suppresses the expression or function of a PA28γ gene, a method for preventing hepatitis C viral infection or suppressing hepatitis C virus growth that includes the step of administering the composition to a subject, and a method for screening an effective component of an anti-hepatitis C virus composition that includes the step of selecting a substance that inhibits the expression or function of a PA28γ gene. |
| US08580757B2 |
Methods of modulating mesenchymal stem cell differentiation
The present disclosure includes compositions and methods for modulating the differentiation of cells having osteogenic differentiation potential (such as mesenchymal stem cells (MSCs)) towards the osteogenic fate, and for obtaining diagnostic and prognostic information relating to diseases and disorders characterized by defects in osteogenic differentiation. The compositions include miRNAs, rm′RNA mimics, miRNA inhibitors, and siRNAs. |
| US08580751B2 |
Esterified α-galactosylceramide
The invention provides esterified α-galactosylceramides effective for cancer treatment and the like, and a medicament containing same. In particular, the invention relates to a compound represented by the formula (I): wherein R1 is a hydrocarbon group having a carbon number of 1 to 30, R2 is a hydrocarbon group having a carbon number of 1 to 20, R3 is a hydrogen atom or hydrocarbon group having a carbon number of 1 to 5, R4 and R5 are the same or different and each is a hydrogen atom or a hydrocarbon group having a carbon number of 1 to 5, or R4 and R5 in combination form a divalent hydrocarbon group having a carbon number of 1 to 5, and optionally form a ring structure together with the adjacent ethylenedioxy, or a salt thereof. |
| US08580750B2 |
Composition for moderating alcohol metabolism and for reducing the risk of alcohol induced diseases
The present invention is directed to a composition of matter, in particular a food composition, dietary or food supplementation, and pharmaceutical composition, respectively. The composition of matter reduces the risk of neuropathy, neurodegenerative diseases including late-onset Alzheimer's disease, and cancer, in particular of pancreatic, esophageal, oropharyngolaryngeal, liver, colorectal, lung and/or breast cancer, in particular the drug and/or alcohol induced risk of said diseases. In this respect, the present invention is also directed to a composition of matter; in particular a food composition, dietary or food supplementation, and pharmaceutical composition, respectively, which supports and/or moderates the alcohol degradation process within the human body. |
| US08580745B2 |
Composition for therapeutic and cosmetic botulinum toxin
This invention relates to a composition of botulinum based pharmaceuticals used for therapeutic and cosmetic treatment. This invention offers an improvement on the prior art by eliminating the potential of blood-borne contamination with botulinum based pharmaceuticals. Recombinant serum albumin is taught for use in the place of human serum albumin as a stabilizing or enhancing agent. |
| US08580737B2 |
Synergistic therapeutic use of prothrombin complex concentrates with FVIII concentrates
The field of the invention is the treatment of acquired bleeding, a clinical condition associated with severe traumatic, peri- or post-operative bleeding. A novel treatment is proposed in which synergistic pro-coagulatory properties of Prothrombin Complex Concentrates (PCC) together with medicaments comprising FVIII and/or vWF are exploited. |
| US08580731B2 |
Insulin-gold nanocluster, pharmaceutical composition for reducing blood glucose comprising the same, and method for detecting adipose cells in tissue by using the same
An insulin-gold nanocluster, a pharmaceutical composition for treating diabetes comprising the insulin-gold nanocluster, and a method for detecting adipose cells in a tissue by using the insulin-gold nanocluster are provided. Herein, the insulin-gold nanocluster of the present invention comprises: a gold nanocluster, and insulin connecting to the gold nanocluster, wherein the insulin-gold nanocluster emits red fluorescence at maximized wavelength of 670 nm. |
| US08580730B2 |
Methods of treating lesional vestibular disorders by administering serotonin 5-HT3 receptor antagonists
The invention relates to serotonin 5-HT3 receptor antagonists or inhibitors of serotonin 5-HT3 receptor gene expression for use in the treatment of a lesional vestibular disorder. |
| US08580729B2 |
Organopolysiloxane compositions containing an active material
This invention relates to organopolysiloxane (silicone) compositions containing an active material chosen to have a desired effect in the composition, such as a perfume, sunscreen, vitamin, drug, biocide, pest repellent, catalyst or cooling agent. The active material is generally an organic material which is not silicon-containing. In particular the invention relates to such composition in which the release of the active material from the composition is inhibited or controlled. The active material is incorporated in a blend of a wax with an organopolysiloxane which has been formed by polymerization in the presence of the wax. It was found that by polymerizing an organopolysiloxane in admixture with molten wax, a stable wax silicone dispersion is obtained which allows ready incorporation of an active material such as a perfume and which releases the perfume only slowly, and may be controlled to release the perfume or other active material in desired circumstances. |
| US08580726B2 |
Color-protecting washing or cleaning agent
The invention relates to washing and cleaning agents for washing or cleaning colored textile surface structures, used for improving the color-fastness thereof. The aim was substantially met by adding polymers obtained by the polymerization of benzoxazine monomers to the agent. |
| US08580722B2 |
Portable cleaning article and the forming method thereof
A portable cleaning article includes a coated capsule and cleaning agent, in which the cleaning agent is contained within the coated capsule, the characteristic in that: the coated capsule having a thin-film layer and an oil layer that is coated over the surface of the thin-film layer to form a portable cleaning article. When the coated capsule is brought into contact with water by the user, the coated capsule dissolves in water for the cleaning agent to exert its cleaning function. |
| US08580715B2 |
Fluorinated cationic surfactant
A composition comprising a fluorinated pyridinium cationic compound of formula (I) wherein Rf is R1(CH2CH2)n—, R1 is a C7 to C20 perfluoroalkyl group interrupted by at least one catenary oxygen atom, each oxygen bonded to two carbon atoms, n is an integer of 1 to 3, and R is H, C1 to C5 linear or branched alkyl, or C1 to C5 linear or branched alkoxy, having surfactant properties for lowering surface tension in an aqueous medium or solvent medium, and for use as a foaming agent. |
| US08580711B2 |
Decreasing or preventing sub-surface geological matter contamination by agrochemicals
Method of exposing agricultural substrates (plant matter 10, animal matter 12) to agrochemicals (A); method of decreasing or preventing sub-surface geological matter (20, 22) contamination resulting from exposing agricultural substrates to agrochemicals; composition [(A)/(T)] 30 used therein; article-of-manufacture including the composition. Includes exposing agricultural substrates to composition including combination (mixture) of an agrochemical and at least one transforming agent capable of decreasing or eliminating concentration of the agrochemical which contacts sub-surface geological matter (at temporally varying times, and at spatially varying depths). Before entering sub-surface geological matter, transforming agent exhibits inactivity for decreasing agrochemical concentration, and inactivity for affecting or/and interfering with agrochemical functionality with respect to agricultural substrates. Transforming agent co-migrates and is co-distributed with agrochemical within and throughout sub-surface geological matter, and exhibits activity for decreasing or eliminating agrochemical concentration therein. Transforming agent activity is exhibited at spatially varying depths, at temporally varying times, within sub-surface geological matter. |
| US08580707B2 |
Use of abscisic acid on ornamental plants
The present invention describes a method for increasing the drought tolerance of selected ornamental plants comprising administering abscisic acid (ABA) or its salts to said plants. |
| US08580705B2 |
Exhaust gas purifying catalyst
An exhaust gas purifying catalyst includes a substrate that defines an exhaust gas passage; a lower catalyst layer formed over the substrate, and an upper catalyst layer formed over the lower catalyst layer. The lower catalyst layer has a lower catalytic precious metal that contains at least one of Pt and Pd, and a lower-layer carrier that supports the lower catalytic precious metal. The upper catalyst layer has an upper catalytic precious metal that contains Rh, and an upper-layer carrier that supports the upper catalytic precious metal. The upper-layer carrier includes an inorganic mixed oxide that contains Ce, Zr, Al, Nd, and at least one element selected from the group consisting of rare earth elements other than Ce and alkaline earth elements. The Nd is unevenly distributed in covering layers that covers surfaces of interior regions within the inorganic mixed oxide. |
| US08580704B2 |
Catalyst precursors, catalysts and methods of producing same
A catalyst precursor comprising (A) a microporous support, (B) a non-noble metal precursor, and (C) a pore-filler, wherein the micropores of the microporous support are filled with the pore-filler and the non-noble metal precursor so that the micropore surface area of the catalyst precursor is substantially smaller than the micropore surface area of the support when the pore-filler and the non-noble metal precursor are absent is provided. Also, a catalyst comprising the above catalyst precursor, wherein the catalyst precursor has been pyrolysed so that the micropore surface area of the catalyst is substantially larger than the micropore surface area of catalyst precursor, with the proviso that the pyrolysis is performed in the presence of a gas that is a nitrogen precursor when the microporous support, the non-noble metal precursor and the pore-filler are not nitrogen precursors is also provided. Methods of producing the catalyst precursor and the catalyst are provided. |
| US08580700B2 |
Method for manufacturing semiconductor device
To provide a method for manufacturing a semiconductor device using a method in which a desired position is rapidly subjected to laser irradiation while switching laser irradiation patterns. With respect to an organic memory element having a structure in which an organic compound layer is interposed between a pair of conductive layers, data is written to the organic memory element by laser irradiation using a laser irradiation apparatus. Further, a laser beam emitted from a laser oscillator is split by a diffractive optical element into a plurality of laser beams, thereby irradiating a plurality of portions on the organic compound layer with laser beams by single irradiation. |
| US08580699B2 |
Embedded catalyst for atomic layer deposition of silicon oxide
Catalyzed atomic layer deposition from a reduced number of precursors is described. A deposition precursor contains silicon, oxygen and a catalytic ligand. A hydroxyl-terminated substrate is exposed to the deposition precursor to form a silicon bridge bond between two surface-bound oxygens. The surface-bound oxygens were part of two surface-bound hydroxyl groups and the adsorption of the deposition precursor liberates the hydrogens. The silicon atom is also chemically-bound to one or two additional oxygen atoms which were already chemically-bound to the silicon within a same deposition precursor molecule. At least one of the additional oxygen atoms is further chemically-bound to the catalytic ligand either directly or by way of a hydrocarbon chain. Further exposure of the substrate to moisture (H2O) results in displacement of the additional oxygen which are replaced by hydroxyl groups from the moisture. The surface is again hydroxyl-terminated and the process may be repeated. The catalytic nature of the reaction enables the deposition to occur at low substrate temperatures. The chemically-embedded nature of the catalyst increases the deposition per cycle thereby reducing the number of precursor exposures to grow a film of the same thickness. |
| US08580698B2 |
Method for fabricating a gate dielectric layer
A method for fabricating the gate dielectric layer comprises forming a high-k dielectric layer over a substrate; forming an oxygen-containing layer on the high-k dielectric layer by an atomic layer deposition process; and performing an inert plasma treatment on the oxygen-containing layer. |
| US08580697B1 |
CVD flowable gap fill
The present invention meets these needs by providing improved methods of filling gaps. In certain embodiments, the methods involve placing a substrate into a reaction chamber and introducing a vapor phase silicon-containing compound and oxidant into the chamber. Reactor conditions are controlled so that the silicon-containing compound and the oxidant are made to react and condense onto the substrate. The chemical reaction causes the formation of a flowable film, in some instances containing Si—OH, Si—H and Si—O bonds. The flowable film fills gaps on the substrates. The flowable film is then converted into a silicon oxide film, for example by plasma or thermal annealing. The methods of this invention may be used to fill high aspect ratio gaps, including gaps having aspect ratios ranging from 3:1 to 10:1. |
| US08580690B2 |
Process of planarizing a wafer with a large step height and/or surface area features
A blanket stop layer is conformally formed on a layer with a large step height. A first chemical mechanical polishing process is performed to remove the blanket stop layer atop the layer in the raised region. A second chemical mechanical polishing process is performed to planarize the wafer using the blanket stop layer as a stop layer when the layer is lower than or at a same level as the blanket stop layer or using the layer as a stop layer when the blanket stop layer is lower than or at a same level as the layer, or a selective dry etch is performed to remove the layer in the raised region. Thus, the layer in the raised region can be easily removed without occurrence of dishing in the non-raised region which is protected by the blanket stop layer. |
| US08580687B2 |
Semiconductor structure and method for making same
One or more embodiments relate to a method for forming a semiconductor structure, comprising: providing a workpiece; forming a dielectric barrier layer over the workpiece; forming an opening through the dielectric barrier layer; forming a seed layer over the dielectric barrier layer and within the dielectric barrier layer opening; and electroplating a first fill layer on the seed layer. |
| US08580685B2 |
Integrated circuit having interleaved gridded features, mask set, and method for printing
A method for fabricating an integrated circuit includes the steps of: providing a substrate having a semiconductor surface; providing a hardmask material on the semiconductor surface. For at least one masking level of the integrated circuit: providing a mask pattern for the masking level partitioned into a first mask and at least one second mask, the first mask providing features in a first grid pattern and the at least one second mask providing features in a second grid pattern, wherein the first and the second grid pattern have respective features which interleave with one another over at least one area; applying a first photoresist layer with the first mask; exposing the first grid pattern using the first mask; developing the first photoresist layer; etching the hardmask material to transfer the first grid pattern in the surface of the substrate; removing the first photoresist layer. |
| US08580684B2 |
Contact elements of semiconductor devices comprising a continuous transition to metal lines of a metallization layer
In sophisticated semiconductor devices, contact elements in the contact level may be formed by patterning the contact openings and filling the contact openings with the metal of the first metallization layer in a common deposition sequence. To this end, in some illustrative embodiments, a sacrificial fill material may be provided in contact openings prior to depositing the dielectric material of the first metallization layer. |
| US08580682B2 |
Cost-effective TSV formation
A device includes a substrate having a first surface, and a second surface opposite the first surface. A through-substrate via (TSV) extends from the first surface to the second surface of the substrate. A dielectric layer is disposed over the substrate. A metal pad is disposed in the dielectric layer and physically contacting the TSV, wherein the metal pad and the TSV are formed of a same material, and wherein no layer formed of a material different from the same material is between and spacing the TSV and the metal pad apart from each other. |
| US08580680B2 |
Metal silicide formation
Techniques for forming metal silicide contact pads on semiconductor devices are disclosed, and in one exemplary embodiment, a method may comprise depositing a metal layer on and between a plurality of raised silicon-based features formed on a semiconductor substrate, the metal layer comprising metal capable of reacting with external silicon-based portions of the features to form a metal silicide. In addition, such a method may also include depositing a cap layer on the metal layer deposited on and between the plurality of raised silicon-based features, wherein a thickness of the cap layer on the metal layer between the raised features is greater than or equal to a thickness of the cap layer on the metal layer on the raised features. Furthermore, such a method may also include annealing the structure to cause portions of the metal layer to react with portions of the external silicon-based portions of the features to form metal silicide pads on and between the raised features. |
| US08580679B2 |
Designs and methods for conductive bumps
Methods, techniques, and structures relating to die packaging. In one exemplary implementation, a die package interconnect structure includes a semiconductor substrate and a first conducting layer in contact with the semiconductor substrate. The first conducting layer may include a base layer metal. The base layer metal may include Cu. The exemplary implementation may also include a diffusion barrier in contact with the first conducting layer and a wetting layer on top of the diffusion barrier. A bump layer may reside on top of the wetting layer, in which the bump layer may include Sn, and Sn may be electroplated. The diffusion barrier may be electroless and may be adapted to prevent Cu and Sn from diffusing through the diffusion barrier. Furthermore, the diffusion barrier may be further adapted to suppress a whisker-type formation in the bump layer. |
| US08580673B2 |
Underfill flow guide structures and method of using same
Underfill flow guide structures and methods of using the same are provided with a module. In particular the underfill flow guide structures are integrated with a substrate and are configured to prevent air entrapment from occurring during capillary underfill processes. |
| US08580672B2 |
Methods of forming bump structures that include a protection layer
One illustrative method disclosed herein includes forming a conductive pad in a layer of insulating material, forming a passivation layer above the conductive pad, performing at least one etching process on the passivation layer to define an opening in the passivation layer that exposes at least a portion of the conductive pad, forming a protective layer on the passivation layer, in the opening and on the exposed portion of the conductive pad, forming a heat-curable material layer above the protective layer, performing an etching process to define a patterned heat-curable material layer having an opening that exposes a portion of the protective layer, performing an etching process on the protective layer to thereby expose at least a portion of the conductive pad and forming a conductive bump that is conductively coupled to the conductive pad. |
| US08580671B2 |
Method of manufacturing semiconductor device and substrate processing apparatus
A method of manufacturing a semiconductor device of the present invention includes a first step of forming a metal oxide film containing at least one or more kinds of elements selected from the group consisting of hafnium, yttrium, lanthanum, aluminum, zirconium, strontium, titanium, barium, tantalum, niobium, on a substrate having a metal thin film formed on the surface, at a first temperature allowing no oxidization of the metal thin film to occur, and allowing the metal oxide film to be set in an amorphous state; and a second step of forming a metal oxide film containing at least one or more kinds of elements selected from the group consisting of hafnium, yttrium, lanthanum, aluminum, zirconium, strontium, titanium, barium, tantalum, niobium on the metal oxide film formed in the first step, up to a target film thickness, at a second temperature exceeding the first temperature. |
| US08580668B2 |
Method of forming ohmic contact layer and method of fabricating light emitting device having ohmic contact layer
A method of manufacturing an ohmic contact layer and a method of manufacturing a top emission type nitride-based light emitting device having the ohmic contact layer are provided. The method of manufacturing an ohmic contact layer includes: forming a first conductive material layer on a semiconductor layer; forming a mask layer having a plurality of nano-sized islands on the first conductive material layer; forming a second conductive material layer on the first conductive material layer and the mask layer; and removing the portion of the second conductive material on the islands and the islands through a lift-off process using a solvent. The method ensures the maintenance of good electrical characteristics and an increase of the light extraction efficiency. |
| US08580657B2 |
Protecting sidewalls of semiconductor chips using insulation films
A method of forming an integrated circuit structure includes providing a wafer having a first semiconductor chip, a second semiconductor chip, and a scribe line between and adjoining the first semiconductor chip and the second semiconductor chip; forming a notch in the scribe line, wherein the notch has a bottom no higher than a top surface of a semiconductor substrate in the wafer; forming a first insulation film over the wafer, wherein the first insulation film extends into the notch; removing a portion of the first insulation film from a center of the notch, wherein a remaining portion of the first insulation film comprises an edge in the notch; and sawing the wafer to separate the first semiconductor chip and the second semiconductor chip. |
| US08580656B2 |
Process for inhibiting corrosion and removing contaminant from a surface during wafer dicing and composition useful therefor
Adherence of contaminant residues or particles is suppressed, corrosion of exposed surfaces is substantially reduced or eliminated during the process of dicing a wafer by sawing. A fluoride-free aqueous composition comprising a dicarboxylic acid and/or salt thereof; a hydroxycarboxylic acid and/or salt thereof or amine group containing acid, a surfactant and deionized water is employed. |
| US08580655B2 |
Processing method for bump-included device wafer
A processing method for a bump-included device wafer which includes an adhesive providing step of providing an adhesive in an annular groove of a carrier wafer so that the adhesive projects from the upper surface of an annular projection of the carrier wafer; a wafer attaching step of attaching and fixing the front side of the device wafer through the adhesive to the front side of the carrier wafer so as to accommodate bumps in a recess of the carrier wafer after performing the adhesive providing step; and a thickness reducing step of grinding or polishing the back side of the device wafer to reduce the thickness of the device wafer to a predetermined thickness after performing the wafer attaching step. |
| US08580653B2 |
Method for fabricating an isolation structure
A method of fabricating an isolation structure including forming a trench in a top surface of a substrate and partially filling the trench with a first oxide, wherein the first oxide is a pure oxide. Partially filling the trench includes forming a liner layer in the trench and forming the first oxide over the liner layer using silane and oxygen precursors at a pressure less than 10 milliTorr (mTorr) and a temperature ranging from about 500° C. to about 1000° C. The method further includes producing a solid reaction product in a top portion of the first oxide. The method further includes sublimating the solid reaction product by heating the substrate in a chamber at a temperature from 100° C. to 200° C. and removing the sublimated solid reaction product by flowing a carrier gas over the substrate. The method further includes filling the trench with a second oxide. |
| US08580650B2 |
Lateral superjunction extended drain MOS transistor
An integrated circuit containing an extended drain MOS transistor with deep semiconductor (SC) RESURF trenches in the drift region, in which each deep SC RESURF trench has a semiconductor RESURF layer at a sidewall of the trench contacting the drift region. The semiconductor RESURF layer has an opposite conductivity type from the drift region. The deep SC RESURF trenches have depth:width ratios of at least 5:1, and do not extend through a bottom surface of the drift region. A process of forming an integrated circuit with deep SC RESURF trenches in the drift region by etching undersized trenches and counterdoping the sidewall region to form the semiconductor RESURF layer. A process of forming an integrated circuit with deep SC RESURF trenches in the drift region by etching trenches and growing an epitaxial layer on the sidewall region to form the semiconductor RESURF layer. |
| US08580649B2 |
Method for manufacturing semiconductor device
Disclosed is a method for manufacturing a semiconductor device, which provides an isolation region in which a dense silicon oxide film is formed in a trench that requires high aspect ratio. The method includes forming an isolation trench using, as an etching mask, a nitride mask film formed on a substrate, forming a liner nitride film in the isolation trench, depositing a flowable silazane compound by a CVD method such that the height of the flowable silazane compound is higher than the upper surface of the nitride mask film from the upper portion of the trench, performing heat treatment under an oxidizing atmosphere to convert the flowable silazane compound film into a silicon oxide film and simultaneously densifying therefore, and planarizing the silicon oxide film to the height of the upper surface of the nitride mask film. |
| US08580646B2 |
Method of fabricating field effect transistors with low k sidewall spacers
Field effect transistors and method for forming filed effect transistors. The field effect transistors including: a gate dielectric on a channel region in a semiconductor substrate; a gate electrode on the gate dielectric; respective source/drains in the substrate on opposite sides of the channel region; sidewall spacers on opposite sides of the gate electrode proximate to the source/drains; and wherein the sidewall spacers comprise a material having a dielectric constant lower than that of silicon dioxide and capable of absorbing laser radiation. |
| US08580644B2 |
Multi-level lateral floating coupled capacitor transistor structures
A semiconductor device includes an active region having a first floating charge control structure and a termination region having a second floating charge control structure. The second floating charge control structure is at least twice as long as the first floating control structure. |
| US08580642B1 |
Methods of forming FinFET devices with alternative channel materials
One illustrative method disclosed herein involves performing a first etching process through a patterned hard mask layer to define a plurality of spaced-apart trenches in a substrate that defines a first portion of a fin for the device, forming a layer of insulating material in the trenches and performing a planarization process on the layer of insulating material to expose the patterned hard, performing a second etching process to remove the hard mask layer and to define a cavity within the layer of insulating material, forming a second portion of the fin within the cavity, wherein the second portion of the fin is comprised of a semiconducting material that is different than the substrate, and performing a third etching process on the layer of insulating material such that an upper surface of the insulating material is below an upper surface of the second portion of the fin. |
| US08580637B2 |
Method of patterning a semiconductor device having improved spacing and shape control and a semiconductor device
A pattern on a semiconductor substrate is formed using two separate etching processes. The first etching process removes a portion of an intermediate layer above an active region of the substrate. The second etching process exposes a portion of the active region of the substrate. A semiconductor device formed using the patterning method has a decreased mask error enhancement factor and increased critical dimension uniformity than the prior art. |
| US08580636B2 |
Highly integrated phase change memory device having micro-sized diodes and method for manufacturing the same
A highly integrated phase change memory device and a method for manufacturing the same is disclosed. The highly integrated phase change memory device includes a semiconductor substrate having a cell area and a peripheral area with impurity regions formed in the cell area and extending in parallel to each other in a first direction to form a striped pattern. A gate electrode is formed in the peripheral area and dummy gate electrodes are formed in the cell area and extending in a second direction perpendicular to the first direction of the impurity regions. An interlayer dielectric layer pattern exposes portions of the cell area and the peripheral area and a PN diode is formed in a space defined by a pair of dummy gate electrodes and a pair of interlayer dielectric layer patterns. |
| US08580630B2 |
Methods for forming a metal gate structure on a substrate
Methods for forming a metal gate structure on a substrate are provided herein. In some embodiments, a method for forming a metal gate structure on a substrate having a dielectric layer formed on the substrate may include depositing a metal layer while providing a process gas comprising oxygen to form an oxygen doped work function layer atop the dielectric layer; and depositing a metal gate layer atop dielectric layer. |
| US08580629B2 |
Method of fabricating semiconductor device using a work function control film
A method of fabricating a semiconductor device may include: preparing a substrate in which first and second regions are defined; forming an interlayer insulating film, which includes first and second trenches, on the substrate; forming a work function control film, which contains Al and N, along a top surface of the interlayer insulating film, side and bottom surfaces of the first trench, and side and bottom surfaces of the second trench; forming a mask pattern on the work function control film formed in the second region; injecting a work function control material into the work function control film formed in the first region to control a work function of the work function control film formed in the first region; removing the mask pattern; and forming a first metal gate electrode to fill the first trench and forming a second metal gate electrode to fill the second trench. |
| US08580628B2 |
Integrated circuit contact structure and method
An integrated circuit having a mis-alignment tolerant electrical contact is formed by providing a semiconductor containing substrate over which is a first FET gate laterally bounded by a first dielectric region, replacing an upper portion of the first FET gate with a second dielectric region, applying a mask having an opening extending partly over an adjacent source or drain contact region of the substrate and over a part of the second dielectric region above the first FET gate, forming an opening through the first dielectric region extending to the contact region and the part of the second dielectric region, and filling the opening with a conductor making electrical connection with the contact region but electrically insulated from the first FET gate by the second dielectric region. A further FET gate may also be provided having an electrical contact thereto formed separately from the source-drain contact. |
| US08580626B2 |
Semiconductor device and method of manufacturing thereof
A semiconductor device and method of manufacturing the device is disclosed. In one aspect, the device includes a semiconductor substrate and a GaN-type layer stack on top of the semiconductor substrate. The GaN-type layer stack has at least one buffer layer, a first active layer and a second active layer. Active device regions are definable at an interface of the first and second active layer. The semiconductor substrate is present on an insulating layer and is patterned to define trenches according to a predefined pattern, which includes at least one trench underlying the active device region. The trenches extend from the insulating layer into at least one buffer layer of the GaN-type layer stack and are overgrown within the at least one buffer layer, so as to obtain that the first and the second active layer are continuous at least within the active device regions. |
| US08580625B2 |
Metal oxide semiconductor transistor and method of manufacturing the same
A method for manufacturing a MOS transistor is provided. A substrate has a high-k dielectric layer and a barrier in each of a first opening and a second opening formed by removing a dummy gate and located in a first transistor region and a second transistor region. A dielectric barrier layer is formed on the substrate and filled into the first opening and the second opening to cover the barrier layers. A portion of the dielectric barrier in the first transistor region is removed. A first work function metal layer is formed. The first work function metal layer and a portion of the dielectric barrier layer in the second transistor region are removed. A second work function metal layer is formed. The method can avoid a loss of the high-k dielectric layer to maintain the reliability of a gate structure, thereby improving the performance of the MOS transistor. |
| US08580624B2 |
Nanowire FET and finFET hybrid technology
Hybrid nanowire FET and FinFET devices and methods for fabrication thereof are provided. In one aspect, a method for fabricating a CMOS circuit having a nanowire FET and a finFET includes the following steps. A wafer is provided having an active layer over a BOX. A first region of the active layer is thinned. An organic planarizing layer is deposited on the active layer. Nanowires and pads are etched in the first region of the active layer using a first hardmask. The nanowires are suspended over the BOX. Fins are etched in the second region of the active layer using a second hardmask. A first gate stack is formed that surrounds at least a portion of each of the nanowires. A second gate stack is formed covering at least a portion of each of the fins. An epitaxial material is grown on exposed portions of the nanowires, pads and fins. |
| US08580623B2 |
Thin film transistor substrate and display device including the same, and method for manufacturing thin film transistor substrate
A TFT (20) includes a semiconductor layer (12s1) of an oxide semiconductor, a source electrode (13sd) and a drain electrode (13dd) provided on the semiconductor layer (12s1) and separated from each other, a gate insulating film (15) covering a portion of the semiconductor layer between the source electrode (13sd) and the drain electrode (13dd), a gate electrode (18gd) provided over the semiconductor layer (12s1) with the gate insulating film (15) being interposed between the gate electrode (18gd) and the semiconductor layer (12s1). The source electrode (13sd) is integrally formed with the source line (13s1). The gate electrode (18gd) is integrally formed with the gate line (18g1). The semiconductor layer (12s1) extends below the source line (13s1). The entireties of the source line (13s1), the source electrode (13sd), and the drain electrode (13dd) are provided on the semiconductor layer (12s1). |
| US08580620B2 |
Method of manufacturing semiconductor device
To aim at improvement of reliability of a semiconductor device of flip chip connection type. In assembling a BGA of flip chip connection type, when a semiconductor chip is solder-connected by a flip chip connection, because solder precoat is formed on the surface of a land on the side of an undersurface of a wiring substrate, the connection between the land and a solder ball, which is an external terminal, is solder-connection, and therefore, it is possible to increase impact resistance of a connection part between the land and the solder ball and to aim at improvement of reliability of the BGA. |
| US08580615B2 |
Method and system for wafer level singulation
A method of singulating a plurality of semiconductor dies includes providing a carrier substrate and joining a semiconductor substrate to the carrier substrate. The semiconductor substrate includes a plurality of devices. The method also includes forming a mask layer on the semiconductor substrate, exposing a predetermined portion of the mask layer to light, and processing the predetermined portion of the mask layer to form a predetermined mask pattern on the semiconductor substrate. The method further includes forming the plurality of semiconductor dies, each of the plurality of semiconductor dies being associated with the predetermined mask pattern and including one or more of the plurality of devices and separating the plurality of semiconductor dies from the carrier substrate. |
| US08580608B2 |
Fabrication method of package structure having embedded semiconductor component
A package structure having an embedded semiconductor component, includes: a chip having an active surface with electrode pads and an inactive surface opposite to the active surface; a first insulating protection layer having a chip mounting area for the chip to be mounted thereon via the active surface thereof; a plurality of connection columns disposed in the first insulating protection layer at positions corresponding to the electrode pads and electrically connected to the electrode pads via solder bumps; an encapsulant formed on one surface of the first insulating protection layer having the chip mounted thereon for encapsulating the chip; and a built-up structure formed on the other surface of the first insulating protection layer and the connection columns. Due to the bending resistance of the encapuslant, the warpage of the built-up structure is prevented. |
| US08580604B2 |
Method for preparing OLED by imprinting process
A method for preparing an OLED by an imprinting process is disclosed, which comprises the following steps: (A) providing a substrate, and a first electrode is formed thereon; (B) coating a mold with a first organic material ink; (C) pressing the mold coated with the first organic material ink on the substrate to transfer the first organic material ink onto the first electrode of the substrate, to obtain a first light-emitting array; (D) baking the substrate having the first light-emitting array formed thereon; and (E) forming a second electrode on the first light-emitting array. |
| US08580601B2 |
Pixel sensor cell with a dual work function gate electrode
Pixel sensor cells, methods of fabricating pixel sensor cells, and design structures for a pixel sensor cell. The pixel sensor cell has a gate structure that includes a gate dielectric and a gate electrode on the gate dielectric. The gate electrode includes a layer with first and second sections that have a juxtaposed relationship on the gate dielectric. The second section of the gate electrode is comprised of a conductor, such as doped polysilicon or a metal. The first section of the gate electrode is comprised of a metal having a higher work function than the conductor comprising the second section so that the gate structure has an asymmetric threshold voltage. |
| US08580595B2 |
Solid-state image sensing device and camera system the same
A solid-state image sensing device includes a plurality of pixels. Each pixel has a photodiode, a first transistor, and a second transistor. The photodiode is constituted by a first-conductivity-type semiconductor region and a second-conductivity-type semiconductor region. The first and second conductivity types are opposite to each other. The first transistor has a first-conductivity-type drain region formed in the second-conductivity-type semiconductor region to transfer signal charge to the drain region. The second transistor has a source region and a drain region which are formed in the second-conductivity-type semiconductor region and which have the first conductivity type. At least one second-conductivity-type potential barrier is provided under the drain region of the first transistor and the source region and/or the drain region of the second transistor. |
| US08580594B2 |
Method of fabricating a semiconductor device having recessed bonding site
The present disclosure provides a method including providing a first substrate; and forming a microelectromechanical system (MEMS) device on a first surface of the first substrate. A bond pad is formed on at least one bonding site on the first surface of the first substrate. The bonding site is recessed from the first surface. Thus, a top surface of the bond pad may lie below the plane of the top surface of the substrate. A device with recessed connective element(s) (e.g., bond pad) is also described. In further embodiments, a protective layer is formed on the recessed connective element during dicing of a substrate. |
| US08580590B2 |
Method for manufacturing polychromatic light emitting diode device having wavelength conversion layer made of semiconductor
A method for manufacturing a polychromatic light emitting diode device, comprising steps of providing an epitaxial substrate and forming a multiple semiconductor layer on the epitaxial substrate, wherein the multiple semiconductor layer comprises an n-type semiconductor layer, a p-type semiconductor layer and an active layer. The active layer emits light of a first wavelength. Thereafter a first wavelength conversion layer is formed on the multiple semiconductor layer. The first wavelength conversion layer is made of semiconductor and absorbs a portion of the light of a first wavelength and emits light of a second wavelength, wherein the second wavelength is longer than the first wavelength. |
| US08580589B1 |
Wafer-level process for fabricating photoelectric modules
A wafer-level process for fabricating a plurality of photoelectric modules is provided. The wafer-level process includes at least following procedures. Firstly, a wafer including a plurality of chips arranged in an array is provided. Next, a plurality of photoelectric devices are mounted on the chips. Next, a cover plate including a plurality of covering units arranged in an array is provided. Next, a plurality of light guiding mediums are formed over the cover plate. Next, the cover plate is bonded with the wafer by an adhesive, wherein each of the covering units covers and bonds with one of the chips, and the light guiding mediums are sandwiched between the cover plate and the wafer. Then, the wafer and the cover plate are diced to obtain the plurality of photoelectric modules. |
| US08580584B2 |
System and method for increasing productivity of organic light emitting diode material screening
A system and method of increasing productivity of OLED material screening includes providing a substrate that includes an organic semiconductor, processing regions on the substrate by combinatorially varying parameters associated with the OLED device production on the substrate, performing a first characterization test on the processed regions on the substrate to generate first results, processing regions on the substrate in a combinatorial manner by varying parameters associated with the OLED device production on the substrate based on the first results of the first characterization test, performing a second characterization test on the processed regions on the substrate to generate second results, and determining whether the substrate meets a predetermined quality threshold based on the second results. |
| US08580583B2 |
Magnetic tunnel junction device and fabrication
A magnetic tunneling junction device and fabrication method is disclosed. In a particular embodiment, the method includes depositing a capping material on a free layer of a magnetic tunneling junction structure to form the capping layer and oxidizing a portion of the capping material to form a layer of oxidized material. |
| US08580582B2 |
Semiconductor fabricating device and method for driving the same, and method for fabricating magnetic tunnel junction using the same
In a method for fabricating a magnetic tunnel junction, a first magnetic layer is formed on a substrate, and a tunnel insulating layer is formed on the first magnetic layer. Subsequently, a second magnetic layer is formed on the tunnel insulating layer. In the method, the first magnetic layer is formed by periodically sputtering a magnetic target while a metal target is continuously sputtered. |
| US08580581B2 |
Substrate for electronic device, stack for electronic device, electronice device, and method for manufacturing the same
A method for manufacturing an electronic device, including a step of aligning and stacking a plurality of substrates, each of the plurality of substrates having a plurality of vertical conductors and magnetic films, the vertical conductors being directed along a thickness direction of the substrate and distributed in a row with respect to a substrate surface, the magnetic films being disposed in place on the substrate surface in a predetermined positional relationship with the vertical conductors, upon aligning the plurality of substrates, the electronic device manufacturing method including a step of applying an external magnetic field to produce a magnetic attractive force between the magnetic films of adjacent stacked substrates and align the vertical conductors by the magnetic attractive force. |
| US08580580B2 |
Magnetic element with varying areal extents
An apparatus and associated method for a magnetic element capable of detecting changes in magnetic states. Various embodiments of the present invention are generally directed to a free layer that has a first areal extent that is sensitive to a magnetic field and a synthetic antiferromagnetic (SAF) layer adjacent to the free layer and has a second areal extent that is greater than the first areal extent. |
| US08580579B2 |
Hydrophilic and lipophilic rhodamines for labelling and imaging
The invention relates to novel and improved photostable rhodamine dyes of the general structural formulae I or II and their uses as fluorescent markers, e.g. for immunostainings and spectroscopic and microscopic applications, in particular in conventional and stimulated emission depletion (STED) microscopy and fluorescence correlation spectroscopy. The partially deuterated analogues are useful as molecular mass distribution tags in mass spectroscopic applications, wherein R1=an unsubstituted or substituted alkyl group, including a cycloalkyl group, or heterocycloalkyl group; R2=H, an unsubstituted or substituted alkyl group, including a cycloalkyl group, or heterocycloalkyl group, or an unsubstituted or substituted aryl group or heteroaryl group, or any combination of such groups; X=CH2, C═O, C═NORa, C═NNRaNRb, CH(ORa), O, S, SO, SO2, or any other derivatives of these groups, with Ra and Rb independently being H or an organic residue, in particular an unsubstituted or substituted (cyclo)alkyl group or heterocycloalkyl group, an unsubstituted or substituted aryl group or heteroaryl group; Z=a negatively charged group with 1, 2, 3, 4 or 5 charges per anion. |
| US08580577B2 |
Method for detecting an analyte in a sample
The present invention relates to a method for detecting an analyte in a sample comprising the steps of providing detection probes being labeled with a first reporter, which detection probes are capable of binding to the analyte, providing a solid support, providing capture probes being bound or capable of binding to the solid support, which capture probes are capable of binding to the analyte, thus concentrating the analyte on the solid support, contacting the sample with the detection probes, the solid support and the capture probes, and detecting the detection probes, wherein the detection of detection probes is conducted in the presence of quenching probes binding to surplus detection probes not being bound to the analyte and thereby quenching at least partially an emission of the first reporter of said surplus detection probes and/or the solid support is labeled with a second reporter different from the first reporter, imaging the sample at an emission wavelength of the second reporter, generating a mask obtained from imaging the sample at the emission wavelength of the second reporter and applying this mask to an image of the sample used for detecting the detection probes. |
| US08580576B2 |
Method for bodily fluid sample transfer during analyte determination
A method for the transfer of a bodily fluid sample (such as a whole blood sample) during the determination of an analyte (e.g., glucose) in the bodily fluid sample includes applying the bodily fluid sample to a sample collection reservoir of an analytical test strip (for example, an electrochemical-based analytical test strip). During such application, the sample collection reservoir is isolated from fluid communication with a determination chamber of the analytical test strip. The analytical test strip is subsequently inserted into a test meter such that the sample collection reservoir is placed into fluid communication with the determination chamber and such that at least a portion of the bodily fluid sample is consequentially transferred from the sample collection reservoir to the determination chamber. The method further includes determining the analyte in the bodily fluid sample transferred to the determination chamber. |
| US08580575B2 |
Reactor plate and reaction processing method
Disclosed herein is a reactor plate which prevents the entry of foreign matter from outside and the pollution of an outside environment. The reactor plate includes a sealed reaction well (5), reaction well channels (13, 15, 17) connected to the reaction well (5), and a syringe (51) for sending a liquid to the reaction well channels (13, 15, 17) and the reaction well (5). The syringe (51) has a cylinder (51a), a plunger (51b), and a cover body (51d). The cover body (51d) has flexibility in the sliding direction of the plunger (51b), and is connected to the cylinder (51a) and the plunger (51b) to create a sealed space (51e) enclosed with the cylinder (51a), the plunger (51b), and the cover body (51d). The cover body (51d) is provided to hermetically cut off a part of an inner wall of the cylinder (51a) to be brought into contact with the plunger (51b) from an atmosphere outside the cylinder (51a). |
| US08580568B2 |
Traceability for automated staining system
A method including automatically displaying information obtained from a first identifier associated with a slide and a second identifier associated with a reagent cartridge. The method further including generating a staining log based on the information obtained from the first identifier and the second identifier. A further method includes displaying a location of a slide within a sample processing system and information obtained from a first identifier associated with the slide in a first table and displaying a location of a reagent cartridge within a sample processing system and information obtained from a second identifier associated with the reagent cartridge in a second table. The first table is then aligned with the second table. |
| US08580565B2 |
Stem cell cultivation devices and methods
The present invention relates to a device and methods for culturing stem cells, and in particular, for culturing ocular stem cells and the use of stem cells cultured using the devices and methods of the invention for the treatment of diseases. |
| US08580563B2 |
Placental stem cells
The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom. |
| US08580548B2 |
Production of nucleic acid
The present invention provides a process for the production of nucleic acid encoding a target protein, which comprises: (a) providing an array of RNA or DNA molecules including one or more encoding the target protein; (b) generating a target protein from the array to form RNA-protein or DNA-protein complexes in which the RNA or DNA molecule is non-covalently or covalently bound to the complex; (c) separating the complexes into compartments wherein most or all of the compartments contain no more than one complex; (d) subjecting the complexes to reaction conditions which allow target protein activity; and (e) selecting nucleic acid encoding the target protein on the basis of the activity associated therewith, wherein when the complex is a DNA-protein complex in which the DNA is non-covalently bound, step b) is performed in the absence of separate compartments for each complex. |
| US08580547B2 |
Variants of PQQ-dependent glucose dehydrogenase having improved substrate specificity
The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) which have an increased substrate specificity compared with the wild type, and also to methods for production and identification thereof. |
| US08580545B2 |
Biodegradable linkers for molecular therapies
A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently bound to the biomaterial; and (c) a substrate, wherein the substrate is covalently bound to the biodegradable cross-linker portion, provided that the biodegradable cross-linker is adapted to hydrolyze by breaking the hydrolyzable bond and thereby release and deliver the biomaterial. A process of making the composition is also provided. |
| US08580544B2 |
Apparatus for introducing biological material, method of introducing biological material and magnetic support for introducing biological material
The invention relates to an apparatus for introducing a biological material, a method of introducing a biological material, and a magnetic support for introducing a biological material with the object of providing an apparatus for introducing a biological material, a method of introducing a biological material, and a magnetic support for introducing a biological material whereby a biological material can be efficiently introduced into a host.The invention comprises: one or more packing units in which a mixture solution containing a large number of magnetic supports carrying a biological material to be introduced into a host such as cells upon using, together with a large number of the hosts in a liquid is pooled; and an introduction treatment unit in which a magnetic force affecting the inside of the packing unit is controlled so as to move the magnetic supports relatively with respect to the host so that the biological material can be introduced into the host. |
| US08580541B2 |
Lignin blockers and uses thereof
Disclosed is a method for converting cellulose in a lignocellulosic biomass. The method provides for a lignin-blocking polypeptide and/or protein treatment of high lignin solids. The treatment enhances cellulase availability in cellulose conversion and allows for the determination of optimized pretreatment conditions. Additionally, ethanol yields from a Simultaneous Saccharification and Fermentation process are improved 5-25% by treatment with a lignin-blocking polypeptide and/or protein. |
| US08580540B2 |
Fractionation of oil-bearing microbial biomass
The invention generally relates to the production of hydrocarbon compositions, such as a lipid, in microorganisms. In particular, the invention provides methods for extracting, recovering, isolating and obtaining a lipid from a microorganism and compositions comprising the lipid. The invention also discloses methods for producing hydrocarbon compositions for use as biodiesel, renewable diesel, jet fuel, and other materials. |
| US08580539B2 |
Phospholink nucleotides for sequencing applications
The present invention provides labeled phospholink nucleotides that can be used in place of naturally occurring nucleotide triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays, and others. |
| US08580538B2 |
Enzymatic production of an ethylenically unsaturated glycoside
Ethylenically unsaturated glycosides of the formula I: wherein n, A, X, R3 and R4 have the meanings given in the description are produced by reacting an ethylenically unsaturated alcohol of formula II: with a saccharide of formula III: in the presence of a glucosidase at a molar ratio of the alcohol to the saccharide of from 2:1 to 30:1 in the presence of a solvent mixture of water and 1,4-dioxane at a weight ratio of 0.1:1 to 9:1 and a weight ratio of solvent mixture to saccharide of from 3:1 to 30:1. |
| US08580534B2 |
Method for incorporation of two oxygen atoms into digested peptides using peptidases
A method for comparative proteomics using a peptidase under enzymatic conditions that permits the optimal incorporation of two oxygen atoms into a digested peptide. The method employs a peptidase to incorporate two 18O atoms into a peptide set derived from a population of proteins at a conditioned state, which is compared to a second peptide set incorporated with a single 16O atom derived from a population of proteins at a second conditioned state. Upon combining the two peptide sets, the populations of proteins are analyzed for qualitative and quantitative differences based on the content of 18O atoms and 16O atoms in the digested peptides using mass spectrometry instrumentation. The method is advantageous to improve the efficiency and timeframe of peptidase catalyzed 18O labeling reactions which increased the accuracy and reliability of quantitative proteomic experiments. |
| US08580533B2 |
Destructible surfactants and uses thereof
The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques. |
| US08580532B2 |
Method for stabilizing α-thrombin in thrombin-containing solution
To provide a method for stabilizing unstable α-thrombin in a thrombin-containing solution, a solution containing stabilized α-thrombin, and a liquid fibrinogen assay reagent containing the solution. The method for stabilizing α-thrombin in a thrombin-containing solution, which includes adjusting the percentage of α-thrombin to 70% or more with respect to the amount of total thrombin in the thrombin-containing solution. |
| US08580531B2 |
Detection of antigens carried by erythrocytes and of anti-erythrocyte antibodies
The invention relates to a method for detecting a plurality of antigenic molecules carried by erythrocytes and/or a plurality of anti-erythrocyte antibodies, said antigenic molecules carried by the erythrocytes consisting of antigenic molecules carried not only by the erythrocytes, but also by at least one other cell population, other than the blood group antigen molecules, said method comprising bringing a sample into contact with distinguishable beads, on which are attached a) antibodies specific for said antigens, or b) erythrocytes or erythrocyte membrane fragment. |
| US08580529B2 |
Diagnosis of collagen IX destruction
A method for detecting or monitoring the presence of protein fragments, cleaved at novel cleaving sites near the N-terminal part of the collagen IX alpha 1 chain, close to the C-terminal part of the NC4 domain, and at the COL3 domain close to the NC3 domain. Neoepitope antibodies against the neoepitopes were created by the cleavages and an epitope in the cleaved N-terminal part of the NC4 domain unique to collagen IX. A diagnostic kit and antibodies useful in carrying out such methods are also presented. |
| US08580522B2 |
Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
Methods for aiding in the diagnosis of disorders including, but not limited to, PDDs (Pervasive Development Disorders), Dysautonomic disorders, Parkinson's disease and SIDS (Sudden Infant Death Syndrome). In one aspect, a diagnosis method comprises analyzing a stool sample of an individual for the presence of a biological marker (or marker compound) comprising one or more pathogens, which provides an indication of whether the individual has, or can develop, a disorder including, but not limited to, a PDD, Dysautonomia, Parkinsons disease and SIDS. Preferably, the presence of one or more pathogens is determined using a stool immunoassay to determine the presence of antigens in a stool sample, wherein such antigens are associated with one or more pathogens including, but not limited to, Giardia, Cryptosporidium, E. histolytica, C. difficile, Adenovirus, Rotavirus or H. pylori. |
| US08580518B2 |
Methods, devices, kits and compositions for detecting roundworm
Methods, devices, kits and compositions for detecting the presence or absence of roundworm in a fecal sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm in a fecal sample from a mammal that may also be infected with one or more of hookworm, whipworm, and heartworm. Confirmation of the presence or absence of roundworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated. |
| US08580515B2 |
Surface-modified single-walled carbon nanotubes and methods of detecting a chemical compound using same
A method for surface modification of single walled carbon nanotubes is described. In one embodiment, the method includes the steps of providing a detergent solution, adding a plurality of single walled carbon nanotubes into the detergent solution, performing a first sonication to disperse the single walled carbon nanotubes in the detergent solution, and performing a second sonication after the first sonication to make detergent encased single walled carbon nanotubes. At least one of the plurality of single walled carbon nanotubes is at least partially wrapped by one or more detergent molecules to make it a detergent encased single walled carbon nanotube. In one embodiment, the detergent comprises SDS, PSS or a combination of them. The surface modified carbon nanotubes can be used to detect a chemical compound by associating a solution of the surface modified nanotubes with the chemical compound and optically detecting a chemical property change of the solution. |
| US08580512B2 |
Yeast-based methods of identifying nucleic acids and compounds for treating neurodegenerative diseases
The disclosure encompasses methods for the screening of small molecules or nucleic acids that may reverse the inhibition of growth of the unicellular yeast Schizosaccharomyces pombe by rotenone. The use of a yeast as the screening target allows for the high-throughput screening of small molecule and nucleic acid libraries for candidates that may then be screened in animal models as therapeutic agents for the treatment of neurodegenerative diseases. The plant-derived isoflavonoid, rotenone, while only moderately inhibitory to S. pombe cell growth on complex rich medium, is highly inhibitory to growth on synthetic minimal medium. S. pombe cells carrying a deletion in the gene pmk1 are hypersensitive to rotenone. S. pombe, therefore, provides a model for elucidating complex 1-independent targets of rotenone, and can serve as a screening tool for identifying compounds or oligonucleotides potentially able to reverse the effects of rotenone or Parkinson's disease in animal or human subjects. |
| US08580510B2 |
Tagged oligonucleotides and their use in nucleic acid amplification methods
The present invention provides nucleic acid amplification systems and methods that desirably reduce or eliminate false positive amplification signals resulting from contaminating biological material, e.g., nucleic acid, that may be present in one or more reagents used in an amplification reaction and/or that may be present in the environment in which an amplification reaction is performed. The invention offers the further advantage of requiring less stringent purification and/or sterility efforts than conventionally needed in order to ensure that enzymes and other reagents used in amplification reactions, and the environment in which an amplification reaction is performed, are free of bacterial or other nucleic acid contamination that may yield false positive results. |
| US08580508B2 |
Fluorescence energy transfer by competitive hybridization
A method is provided for detecting the presence of nucleotides or monitoring nucleotide amplification. It utilizes fluorescence energy transfer by competitive hybridization. Competitive hybridization is achieved by using unequal length complementary probes which have a fluorophore on one probe and a quencher on the other. The fluorophore and quencher are juxtaposed in a manner wherein the proximity of the quencher to the fluorophore produces quenching of the fluorescence of the fluorophore. |
| US08580505B2 |
Fast PCR for STR genotyping
Disclosed is a method of amplifying a nucleic acid sequence, wherein the method comprises subjecting a reaction mixture to at least one amplification cycle, wherein the reaction mixture comprises a double-stranded nucleic acid and at least two primers capable of annealing to complementary strands of the double-stranded nucleic acid and amplifying at least one short tandem repeat (STR) using a Family A DNA polymerase in a Fast PCR protocol having a two-step amplification cycle in 25 seconds or less. Also disclosed are real-time PCR methods using the two-step protocol and kits for STR profiling using the Fast PCR protocol. |
| US08580499B2 |
Detection and/or quantification method of target molecules on a solid support
The present invention relates to a method and device for detecting and/or quantifying one or multiple target molecules present in a solution by quantifying online their binding on specific capture molecules immobilized at different locations (spots) of a surface of an optically transparent solid support without substantial detection of target molecules present in solution. The present invention allows multiple target assays to be performed in a simultaneous detection. More particularly, the invention comprises detecting in real-time the hybridization between capture DNA molecules present on a micro-array and target polynucleotides present in solution. The invention is also related to real-time PCR of multiple targets on a micro-array. |
| US08580495B2 |
Polynucleotides for the amplification and detection of Chlamydia trachomatis and Neisseria gonorrhoeae
Polynucleotides useful for detecting Chlamydia trachomatis and/or Neisseria gonorrhoeae in a test sample, kits, a nucleic acid amplification method and detection method including the same. |
| US08580488B2 |
Cell culture model for acquired chemoresistance of chronic myelogenous leukemia and related methods for identifying agents to overcome resistance
A method of generating a chronic myelogenic leukemia (CML) acquired chemoresistant culture model is provided. Such a method may comprise providing a naïve blast crisis CML cell line; administering/contacting the cell line with a mutation-inducing dose of imatinib; maintaining a culture of the treated cell line for a period of time until the treated cell line relapses and repopulates the culture; and determining the repopulated cell culture is a CML acquired chemoresistant cell line by detecting a BCR-ABL mutation, wherein the acquired chemoresistance is achieved by a BCR-ABL mutation. |
| US08580485B2 |
Method for forming three-dimensional pattern
A method for forming a three-dimensional pattern includes following steps. A shaped workpiece having an inner surface and an outer surface is provided, and a first photoresist layer and a second photoresist layer are respectively formed on the outer surface and the inner surface. The shaped workpiece is placed on a transparent fixture. The first photoresist layer and the second photoresist layer are exposed and developed, such that the first photoresist layer forms a patterned photoresist layer, and the second photoresist layer forms an etching protection layer. The shaped workpiece is etched to form the three-dimensional pattern on the outer surface of the shaped workpiece. The patterned photoresist layer and the etching protection layer are removed. |
| US08580484B2 |
Photosensitive compositions useful for forming active patterns, methods of forming such active patterns and organic memory devices incorporating such active patterns
Example embodiments herein relate to compositions useful in forming organic active patterns that may, in turn, be incorporated in organic memory devices. The compositions comprise N-containing conjugated electroconductive polymer(s), photoacid generator(s) and organic solvent(s) capable of dissolving suitable quantities of both the electroconductive polymer and the photoacid generator. Also disclosed are methods for patterning organic active layers formed using one or more of the compositions to produce organic active patterns, portions of which may be arranged between opposed electrodes to provide organic memory cells. The methods include directly exposing and developing the organic active layer to obtain fine patterns without the use of a separate masking pattern, for example, a photoresist pattern, thereby tending to simplify the fabrication process and reduce the associated costs. |
| US08580483B2 |
Method of making nozzle chip
The present disclosure provides a method of making a nozzle chip including a step of forming an ejection orifice row by performing irradiation with light rays using a mask having ejection orifice row patterns that form an ejection orifice row pattern of one nozzle chip when the ejection orifice row patterns are connected to each other through a connection portion. The mask is configured such that, with respect to a direction in which ejection orifices of the ejection orifice row are arranged, an absolute value of off-axis telecentricity of one of the light rays with which an ejection orifice that is at the smallest distance from the connection portion is irradiated is less than an absolute value of off-axis telecentricity of one of the light rays with which an ejection orifice that is at the greatest distance from the connection portion is irradiated. |
| US08580480B2 |
Radiation-sensitive resin composition, method for forming resist pattern, polymer and compound
A radiation-sensitive resin composition includes (A) a fluorine-containing compound that includes a group shown by the following formula (1), and (B) a photoacid generator. wherein RC represents a (p+1)-valent aromatic ring group, Q represents a linking group obtained by removing one hydrogen atom from a monovalent hydrophilic group, RE represents a hydrogen atom or a hydrocarbon group having 1 to 10 carbon atoms, p is an integer from 1 to 5, provided that a plurality of Q and a plurality of RE may respectively be either the same or different when p is an integer from 2 to 5, and “*” indicates a bonding hand. |
| US08580477B2 |
Aqueous base-developable negative-tone films based on functionalized norbornene polymers
Embodiments in accordance with the present invention encompass negative-tone, aqueous base developable, self-imageable polymer compositions useful for forming films that can be patterned to create structures for microelectronic devices, microelectronic packaging, microelectromechanical systems, optoelectronic devices and displays. |
| US08580476B2 |
Method for preparing particulate release agent, toner using the particulate release agent, and method for preparing the toner
A toner for developing an electrostatic image is provided. The toner includes at least a binder resin; a colorant; and a particulate release agent. The particulate release agent is prepared by heating the release agent to a temperature not lower than a melting point of the release agent to melt the release agent, dissolving the melted release agent in a supercritical fluid or a sub-critical fluid, and feeding the solution into a liquid so that the solution is depressurized and the particulate release agent is formed in the liquid. |
| US08580475B2 |
Electrostatic charge image developing carrier, method of producing electrostatic charge image developing carrier, electrostatic charge image developing developer, process cartridge, image forming apparatus, and image forming method
An electrostatic charge image developing carrier includes a core particle and a coating layer with which the surface of the core particle is coated. The coating layer includes an acrylic resin having a constituent unit in which a silicone chain is disposed in a branch. |
| US08580472B2 |
Rosin-based resin and toner containing same
Disclosed is a polyester resin comprising the polycondensation product of (a) at least one diacid, acid ester, or diester; and (b) at least one diol; wherein either (i) at least one diacid, acid ester, or diester comprises a rosin diacid, rosin acid ester, or rosin diester; or (ii) at least one diol comprises a rosin diol, and wherein at least one of the rosin diacid, rosin acid ester, rosin diester, or rosin diol is either (A) an ester of a functionalized rosin or an ester of a reduced functionalized rosin, or (B) a dimerized rosin. Also disclosed is a toner composition comprising particles which comprise the disclosed polyester resin and an optional colorant. |
| US08580458B2 |
Fuel cell system with a cell unit and fuel tank unit in a housing and electronic device
A fuel cell system that includes a cell unit comprising a fuel cell, a fuel tank unit for storing a fuel to be supplied to the cell unit, and a fuel feed unit for supplying the fuel from the fuel tank unit to the cell unit in a thin housing having a substantially rectangular parallelepiped shape. The fuel tank unit, the fuel feed unit, and the cell unit are located in a specific order in one direction between two opposite ends of the housing. The fuel tank unit includes a valve, which supplies fuel to the fuel feed unit and opens to supply the fuel to the fuel feed unit only when the fuel tank unit is mounted. The fuel feed unit connects sides of the fuel tank unit and the cell unit that face each other and reduces a pressure of a gaseous fuel supplied from the fuel tank unit. |
| US08580456B2 |
Phase stable doped zirconia electrolyte compositions with low degradation
A solid oxide fuel cell (SOFC) includes a cathode electrode, a solid oxide electrolyte, and an anode electrode. The electrolyte and/or electrode composition includes zirconia stabilized with (i) scandia, (ii) ceria, and (iii) at least one of yttria and ytterbia. The composition does not experience a degradation of ionic conductivity of greater than 15% after 4000 hrs at a temperature of 850° C. |
| US08580454B2 |
Combined subgasket and membrane support
A combined subgasket and membrane support for a fuel cell is provided. The combined subgasket and membrane support includes a substantially fluid impermeable feed region circumscribing a porous membrane support region. The membrane support region is integrally formed with the feed region. At least one of the membrane support region and the feed region is at least partially formed by a radiation-cured structure. A method for fabricating the subgasket and membrane support for the fuel cell is also provided. |
| US08580451B1 |
Fuel cell system and method of operation that recycles water from the fuel processor raffinate of a hydrogen separator
A power generation system and a fuel processor for use within a power generation system. A fuel processor is connected to both a fuel supply line and a water supply line. The fuel processor reacts the hydrocarbon fuel with the water to produce hydrogen gas and raffinate gases. The hydrogen gas is directed into a hydrogen gas line. The raffinate gases are directed into a raffinate gas line. A fuel cell is powered using the hydrogen gas. A heat exchanger is provided that exchanges heat between the fuel supply line, the water supply line, the hydrogen gas line and the raffinate gas line. This enables heat to be recycled. In addition the raffinate gases also travel into a water recovery subsystem. The water recovery subsystem condenses water out of the raffinate gases The recovered water is returned to the system. |
| US08580449B2 |
Fuel cell system and power supply control method
In order to determine the air stoichiometric ratio without using multidimensional mapping, a fuel cell system of the invention computes a command current value and command voltage value in a fuel cell during low-efficiency electrical power generation based on the required electrical power, estimates a reference voltage of the fuel cell from the command voltage value and the water temperature when the command current value is taken as a reference current, determines the difference between the reference voltage thus obtained and the command voltage value as an air concentration overvoltage target value, computes the air stoichiometric ratio based on the air concentration overvoltage target value, computes the air amount during low-efficiency electrical power generation based on the air stoichiometric ratio, and controls the amount of air supplied to the fuel cell according to the air amount thus computed. |
| US08580448B2 |
Fuel cell with selectively conducting anode component
By incorporating a selectively conducting component in electrical series with the anode components in a solid polymer fuel cell, degradation during startup and shutdown can be reduced. As a result, the startup and shutdown procedures can be simplified and consequently certain system apparatus may be omitted. The anode does not need to be rapidly purged with hydrogen on startup or with air on shutdown. Additionally, the auxiliary load usually employed during such purging is not required. |
| US08580445B2 |
Shutdown strategy to avoid carbon corrosion due to slow hydrogen/air intrusion rates
A fuel cell system including a fuel cell stack having a plurality of fuel cells, each of the fuel cells including an electrolyte membrane disposed between an anode and a cathode, an anode supply manifold in fluid communication with the anodes of the fuel cells, the anode supply manifold providing fluid communication between a source of hydrogen and the anodes, an anode exhaust manifold in fluid communication with the anodes of the fuel cells, and a fan in fluid communication with the anodes of the fuel cells, wherein the fan controls a flow of fluid through the anodes of the fuel cells after the fuel cell system is shutdown. |
| US08580438B2 |
Monolithic three-dimensional electrochemical energy storage system on aerogel or nanotube scaffold
A monolithic three-dimensional electrochemical energy storage system is provided on an aerogel or nanotube scaffold. An anode, separator, cathode, and cathodic current collector are deposited on the aerogel or nanotube scaffold. |
| US08580434B2 |
Cathode active material, method of preparing the same, cathode containing the cathode active material, and lithium battery containing the cathode active material
A cathode active material includes a lithium metal phosphate represented by Formula 1; and one or more compounds selected from the group consisting of a metal oxynitride, a metal nitride, and a mixture thereof: LiMPO4 |
| US08580432B2 |
Nano graphene reinforced nanocomposite particles for lithium battery electrodes
A solid nanocomposite particle composition for lithium metal or lithium ion battery electrode applications. The composition comprises: (A) an electrode active material in a form of fine particles, rods, wires, fibers, or tubes with a dimension smaller than 1 μm; (B) nano graphene platelets (NGPs); and (C) a protective matrix material reinforced by the NGPs; wherein the graphene platelets and the electrode active material are dispersed in the matrix material and the NGPs occupy a weight fraction wg of 1% to 90% of the total nanocomposite weight, the electrode active material occupies a weight fraction wa of 1% to 90% of the total nanocomposite weight, and the matrix material occupies a weight fraction wm of at least 2% of the total nanocomposite weight with wg+wa+wm=1. For a lithium ion battery anode application, the matrix material is preferably amorphous carbon, polymeric carbon, or meso-phase carbon. Such a solid nanocomposite composition provides a high anode capacity and good cycling stability. For a cathode application, the resulting lithium metal or lithium ion battery exhibits an exceptionally high cycle life. |
| US08580428B2 |
Battery and method for manufacturing the same
A battery (100) provided by the present invention includes an electrode body (80) having a positive electrode and a negative electrode (84), a bottomed battery case (10) for holding the electrode body (80), and a current collecting plate (20) that connects the battery case (10) with either the positive electrode or the negative electrode of the electrode body. A part of the current collecting plate (20) and a bottom part (16) of the battery case (10) are fixed to each other by welding, and a sealed structure (40) that surrounds a weld (30) composed of a portion that has been welded is formed at the periphery of the weld (30). |
| US08580427B2 |
Assembled battery
In this assembled battery, connections between electrode terminals of electrical cells and connection members for the electrode terminal are reliably maintained for a long period of time. The electrode terminal is formed in a tapered pillar shape whose width decreases from the front end of the electrode terminal toward a battery case. Also, a groove, which is shaped from the front end toward the battery case and divides at least a portion of the front end into segmented portions, is provided to the electrode terminal. The segmented portions are elastically deformable to move close to or away from each other. The bus bar (connection member for the electrode terminals) includes a through-hole whose width decreases from the front end of the electrode terminal toward a battery case. The bus bar is fitted to the electrical terminal, by elastically deforming and moving the segmented portions close to each other. |
| US08580422B2 |
Aqueous electrolyte energy storage device
An electrochemical device including a housing and a stack of electrochemical cells in the housing. Each electrochemical cell includes an anode electrode, a cathode electrode, a separator located between the anode electrode and the cathode electrode and an electrolyte. The electrochemical device also includes a current collector located between adjacent electrochemical cells, an anode bus operatively connected to the anodes of the electrochemical cells in the stack and a cathode bus operatively connected to the cathodes of the electrochemical cells in the stack. The housing, the anode electrode, the cathode electrode, the separator, the anode bus and the cathode bus are non-metallic. |
| US08580419B2 |
Secondary battery with improved storage characteristics and method for manufacturing the same
Provided is a secondary battery comprising a separator having an inorganic layer wherein active sites of inorganic particles in the inorganic layer are modified into non-reactive sites. Use of the separator leads to improvements in wettability of an electrolyte and thermoelectric stability and storage characteristics of the secondary battery. Provided is also a method of manufacturing the same secondary battery. |
| US08580415B2 |
Method and apparatus for an electrical interface
In accordance with an example embodiment of the present invention, an apparatus, comprises an energy storage device having an interface and at least one terminal, the interface having first and second surfaces, the first surface having at least one first surface opening and the second surface having at least one second surface opening, wherein the at least one first surface opening allows access to the at least one terminal, wherein the at least one second surface opening allows access to the at least one terminal, and wherein the at least one first surface opening is distinct from the at least one second surface opening. |
| US08580412B2 |
Battery pack
In a battery pack, a component for attaching a secondary protection device to a bare cell may be omitted to reduce manufacturing costs and improve productivity. The battery pack includes a bare cell, a flexible printed circuit board in which at least one portion thereof contacts the bare cell, the flexible printed circuit board being electrically coupled to the bare cell through a lead pattern surrounded by an insulation cover, a secondary protection device on the flexible printed circuit board, the secondary protection device being electrically coupled to the flexible printed circuit board through the lead pattern, and a protective circuit module electrically coupled to the flexible printed circuit board through the lead pattern. |
| US08580405B2 |
Naphthothiophene compound and organic light-emitting device including the same
The present invention provides a novel naphthothiophene compound having a high lowest excited triplet level (T1). |
| US08580403B2 |
Organic light-emitting diode, display and illuminating device
According to one embodiment, there is provided an organic light-emitting diode including an anode and a cathode which are arranged apart from each other, and an emissive layer interposed between the anode and the cathode and including a host material and an emitting dopant. The host material includes a polymer containing dibenzothiophene backbones represented by the following formula (1) as repeating units: wherein n is an integer of from 20 to 10,000. |
| US08580401B2 |
Curable material and its application
A curable material is provided. The curable material has the structure of formula I or formula II: wherein, X, R1, R2, m1 to m3, and n1 to n3 are defined as cited in the description. |
| US08580395B2 |
Electroluminescent polymers, method for the production thereof, and use thereof
The present invention relates to electroluminescent polymers which comprise 2-vinylthiophenylbenzene derivatives as recurring units, to a process for the preparation thereof, to blends and formulations comprising these polymers, and to the use of these polymers in electronic devices, in particular in organic light-emitting diodes, so-called OLEDs. |
| US08580394B2 |
3-coordinate copper(I)-carbene complexes
Novel phosphorescent trigonal copper carbene complexes are provided. The complex comprise a carbene ligand coordinated to a three coordinate copper atom. The complex may be used in organic light emitting devices. In particular, the complexes may be especially useful in OLEDs used for lighting applications. |
| US08580389B2 |
Articles comprising phyllosilicate composites containing mica
Disclosed is a mica paper composite and a process for making the mica paper composite. Articles comprising the mica paper composite are also disclosed. |
| US08580387B1 |
Polyurea composite armor
A composite armor including a ballistic armor layer and a directly attached polyurea layer. The polyurea layer is the cured reaction product of an isocyanate curing agent and a mixture of diamines having the general formula: H2N-Ph-(C═O)—O—(CH2—CH2—CH2—CH2—O)n—(C═O)-Ph-NH2, wherein in the mixture n in the ranges from 3 to 14 and the weight average value of n is about 9 to 10. Ph represents phenyl. In a preferred embodiment, the polyurea layer is the strike face. The composite armor is useful for light armor applications in which weight is a factor such as military vehicle armor and military boat armor. |
| US08580383B2 |
First-wall component for a fusion reactor with a heat sink of a copper alloy
A first-wall component of a fusion reactor has a heat shield and a heat sink. The heat shield is formed of a material from the group of graphite material, carbidic material, tungsten and tungsten alloy. The heat sink is formed of a spray-compacted copper alloy. |
| US08580380B2 |
Polybenzazole fiber and pyridobisimidazole fiber
To provide fibers which retain the excellent heat resistance and flame retardancy inherent in polybenzazole fibers and pyridobisimidazole fibers, have improved post-processability and neither necessitate considerable change in production process conditions nor require a high-temperature and long-time heating treatment. With respect to the polybenzazole fiber and pyridobisimidazole fiber, in an electron diffraction diagram of a surface layer part (from the surface to 1 μm) of the fibers, the fibers containing a crystal present in a state satisfying that S2/S1 is in a prescribed range, wherein S1 is a diffraction peak area derived from a crystal (200) plane and S2 is a diffraction peak area derived from a plurality of other crystal planes along an equatorial direction profile. |
| US08580378B2 |
Organic glass for automobile and process for producing the same
An organic glass for automobile is provided which has excellent weatherability, wear-resistance and abrasion-resistance, and which can be mass-produced by a simple and inexpensive process. The organic glass comprises a transparent resin base plate 12 and a hard coat layer 14 formed on at least one surface of the resin base plate. The hard coat layer includes an organic thin film 16 formed by vacuum deposition polymerization. |
| US08580372B2 |
Optical film
The present invention provides an optical film comprising a substrate having a first optical surface and a second surface and a micro structure layer on the first optical surface of the substrate, wherein the micro structure layer comprises a plurality of first light-adjusting structures selected from the group consisting of prism columnar structures, conical columnar structures, solid angle structures and orange-segment like structures and a combination thereof and a plurality of second light-adjusting structures selected from the group consisting of arc columnar structures, lens-like structures, and capsule-like structures and a combination thereof, wherein at least a portion of the second light-adjusting structures has a height greater than those of all the first light-adjusting structures. The optical film of the present invention will not suffer the damage caused on the microstructure layers while achieving a light-gathering effect and effectively reducing optical interference. |
| US08580370B2 |
Adhesive assembly and method for making same
An adhesive assembly includes a first member, a second member, and an adhesive. The first member includes a first surface, a receiving groove defined in the first surface, a flowing groove defined in the first surface apart from the receiving groove, an injecting inlet defined in the bottom surface of the receiving groove, and an outlet defined in the bottom surface of the flowing groove. The flowing groove partially communicates with the receiving groove. The adhesive is injected in the receiving groove through the injecting inlet to adhere the first member to the second member. A method for making the adhesive assembly is also provided. |
| US08580369B2 |
Method and apparatus for wrapping a shipment
Embodiments of the invention relate to a cover, a method of covering, and a cover system to be used with shipments of products transported by air with ULDs. The cover system provides thermal protection to temperature-sensitive products in or on the ULD. The cover system maintains the proper relative humidity level and gas concentrations (oxygen, carbon dioxide and ethylene) for horticultural product loads. The cover system can also have antimicrobial properties. In addition, the cover system decreases the amount of water vapor released in the cargo holds which is known to affect the reliability of the aircraft smoke detection system and to cause false fire alarms. |
| US08580366B2 |
Hose for refrigerant transport use
A hose for refrigerant transport use comprising an inner layer with superior deterioration resistance performance. The innermost layer comprised in the hose for refrigerant transport use of the present invention is formed using a polyamide resin composition comprising a polyamide and, per 100 parts by mass thereof, from 0.5 to 20 parts by mass of an acid acceptor. |
| US08580361B2 |
Insulated glass unit with sealant composition having reduced permeability to gas
The invention relates to a high thermal efficiency, insulated glass unit structure sealed with a cured composition containing, inter alia, moisture-curable linear silylated resin and organic nanoclay, the cured composition exhibiting low permeability to gas(es). |
| US08580359B2 |
Bottom chassis, method of fabricating the same, and liquid crystal display including the same
Provided are a bottom chassis, a method of fabricating the same, and a liquid crystal display (LCD) including the same. The bottom chassis is fabricated using an aluminum alloy plate including, by weight, 0.5 to 1.5% manganese, 0.8 to 1.5% magnesium, 0.01 to 0.03% titanium, less than 0.02% molybdenum, and 96% or more aluminum. |
| US08580353B2 |
Method for treating surface of glass substrate and apparatus for performing same
A method for treating a surface of a glass substrate according to the invention has the steps of placing the glass substrate into a vacuum treatment chamber, introducing a gas into the vacuum treatment chamber, providing electric power to generate an ion source and using the ion source to treat the surface of the glass substrate. By this way, the invention can achieve an effect of surface cleaning and further render the conductive film to be coated on the glass substrate in the subsequent stage to have a reduced surface resistance, thereby improving the conductivity of the glass substrate. The film coated on the glass substrate in the subsequent stage will have higher crystalline level as well. |
| US08580350B2 |
Corrosion resistant neutron absorbing coatings
A method of forming a corrosion resistant neutron absorbing coating comprising the steps of spray or deposition or sputtering or welding processing to form a composite material made of a spray or deposition or sputtering or welding material, and a neutron absorbing material. Also a corrosion resistant neutron absorbing coating comprising a composite material made of a spray or deposition or sputtering or welding material, and a neutron absorbing material. |
| US08580349B1 |
Pigmented spray texture material compositions, systems, and methods
A coating material adapted to be applied to a target surface comprises a texture material base and pigment material. The texture material base comprises solvent/carrier material comprising water, resin/binder material comprising a latex binder, and filler material comprising a polymeric thickener. The texture material base and the pigment material are combined and deposited on the target surface to form a durable, irregular, colored surface. |
| US08580348B2 |
Treatment of textile materials
The present invention provides a method for treating textile material to confer flame retardant properties, the method comprising the steps of impregnating the material with an aqueous solution of a treatment agent which is a poly(hydroxyorgano)phosphonium compound; drying the impregnated material; curing the dried impregnated material with ammonia to produce a cured, water-insoluble polymer which is mechanically fixed within the fibers of the material; oxidizing the cured polymer to convert trivalent phosphorus to pentavalent phosphorus; and washing and drying the material; wherein one or both of steps (d) and (e) result in the co-production of an aqueous effluent; and wherein the conditions are controlled such that the atomic ratio of N:P present on the material increases during step (c) by 0.8 or more. |
| US08580347B2 |
Method for producing calcium phosphate complex
A method of the present invention for producing a calcium phosphate complex including a substrate and calcium phosphate bonded to a surface of the substrate, the method includes the steps of: (a) treating the surface of the substrate; and (b) bonding the calcium phosphate onto the surface of the substrate after the step (a), the step (a) being the step of placing the surface of the substrate in contact with ozone water. Therefore, the method of the present invention makes it possible to bond calcium phosphate and the substrate at a high bonding strength and at a high coverage. In addition, the method of the present invention provides an easy method for producing a calcium phosphate complex. |
| US08580345B2 |
Method of protecting a fixture
A method including placing a body defining an undifferentiated lumen therein over a portion of a fixture coupled to a building structure, the body having at least one opening that can be expanded from a contracted state and that is biased toward the contracted state, the placing including applying an expansion force to the opening; conforming the body to a shape of the fixture at a contact portion where the fixture contacts the structure by releasing the expansion force; and treating the structure. |
| US08580344B2 |
Stamp usage to enhance surface layer functionalization and selectivity
This disclosure provides methods, devices and systems for using a stamp to enhance selectivity between surface layers of a substrate, and to facilitate functionalizing selected layers. An array of flat stamps may be used to concurrently stamp multiple regions of a substrate to transfer one or more substances to the topmost layer or layers of the substrate. If desired, the affected regions of the substrate may be isolated from each other through the use of a reactor plate that, when clamped to the substrate's surface, forms reaction wells in the area of stamping. The stamp area can, if desired, be configured for stamping the substrate after the reactor plate has been fitted, with the individual stamps sized and arranged in a manner that permits stamping within each reaction well. If applied in a combinatorial process, a robotic process may be used to transfer multiple combinations of contact substances and processing chemicals to each reaction well to perform many concurrent processes upon a single substrate (e.g., a single coupon). The methods, devices and systems provided facilitate semiconductor design, optimization and qualification, and may be adapted to production manufacturing. |
| US08580341B2 |
Method of making composite membrane
The present invention provides a composite membrane comprising a porous base membrane and a polyamide coating disposed on said porous base membrane, said polyamide coating comprising a C3-C8 cyclic carbonyl compound and a C1-C8 amide compound, said amide compound comprising at least one N—H moiety. In addition the present invention provides a method of preparing a composite membrane comprising contacting under interfacial polymerization conditions an organic solution comprising a polyacid halide with an aqueous solution comprising a polyamine, said contacting being carried out on a surface of a porous base membrane, said organic solution further comprising a C3-C8 cyclic carbonyl compound, said aqueous solution comprising a C1-C8 amide compound, said amide compound comprising at least one N—H moiety. |
| US08580337B2 |
Thermoplastic coating and removal using bonding interface with catalytic nanoparticles
An article may be fabricated by coupling a thermoplastic to a bonding interface layer, and applying a coating layer to the surface of the bonding interface layer. A bonding interface layer may comprise catalytic nanoparticles embedded within and/or encapsulated by one or more radiatively unstable polymers. Application of ionizing radiation to the article may release a catalyst at the bonding interface. Application of heat and/or stress to the article may enhance catalytic degradation of the remaining bonding interface and uncoupling of the thermoplastic from the coating layer. Embodiments of methods, compositions, articles and/or systems may be disclosed. |
| US08580330B2 |
Method of producing a canola protein isolate
Canola protein isolates are provided which contain both albumin and globulin protein fractions that are soluble and transparent in an acidic aqueous environment. The canola protein isolates are completely soluble in water at low pH, low in phytic acid and useful in products for human consumption, pet foods and aquaculture. |
| US08580328B2 |
Salt substitute and composition, for example food composition, comprising it
Methods for replacing salt in a food composition comprising substituting all or part of the salt in the food composition with vinegar, while conserving the food composition's gustative, olfactive and physical values the presence of salt instead of the vinegar would give. In various embodiments, the food composition is a product of bakery comprising water, salt, yeast, and flour or a mix of flours. For example, vinegar may replace at least 60% of the salt in the food composition, and may have an acidity of 3% to 10%. |
| US08580326B2 |
Treating meat from dark-cutting carcasses using an acidification process
A system and method for treating dark-cutter meat includes contacting the meat with one or more acidulants in an amount and for a time sufficient to allow the acidulant to hydrolyze and decrease the pH level of the meat. The acidulant may be added to the meat by injecting, marinating, spraying, or rubbing. |
| US08580314B2 |
Dried and irradiated skin equivalents for ready use
The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes. |
| US08580311B2 |
Nanoparticles
Methods for the preparation of polymer-templated core-shell nanoparticles include the steps of (a) preparing a cationic polymeric core material comprising polymeric micelles, and (b) coating the core material with a silica-comprising shell by depositing the shell onto the polymeric micelles from at least one silica precursor to form the core-shell nanoparticles. Compositions which include the core-shell nanoparticles are adapted to facilitate controlled delivery of at least one active agent into a system in response to controlled changes in the pH of the system. |
| US08580308B2 |
Modafinil pharmaceutical compositions
Pharmaceutical compositions comprising modafinil in the form of particles of defined size and methods for preparing same. The particle size of modafinil can have a significant effect on the potency and safety profile of the drug. |
| US08580297B2 |
Components for producing amphoteric liposomes
The invention suggests amphoteric lipids wherein one or more amphoteric groups having an isoelectric point between 4 and 9 are substituted on a membranous or membrane-forming amphiphilic substance, as well as liposomes containing such compounds. |
| US08580289B2 |
Tissue matrix system
The present application discloses matrix compositions to support the repair of tissue defects such as an injury to tendon tissue, ligament tissue, vascular tissue, dermal tissue, or muscle tissue. A matrix described herein comprises a polyester polymer entangled with a polysaccharide polymer. Also disclosed are methods of preparing a matrix, and methods of using a matrix in the repair of tissue. In certain configurations, a matrix can comprise a polyester cross-linked with a polysaccharide, which can be an oxidized polysaccharide. In some configurations, a matrix can further comprise one or more additional components, such as a growth factor or an anti-infective agent. In some configurations, a matrix can be a viscous fluid or a paste, while in other configurations a matrix can be comprised by a solid such as a plug, a granule or a membrane. |
| US08580287B2 |
Oil-based agrochemical compositions with increased viscosity
Suggested are oil-based agrochemical compositions with increased viscosity, comprising (a) biocides, (b) hydrophobic carriers, and (c) polymers selected from the group consisting of poly(meth)acrylates, polymaleates and polyfumarates. |
| US08580285B2 |
Clarifying agents for organomodified silicones
There is provided herein a composition comprising a silicone copolymer of the general formula (I) MaMEcDdDEeTfTEgQh where M=R1R2R3SiO1/2; ME=R4R5RESiO1/2; D=R6R7SiO2/2; DE=R8RESiO2/2; T=R9RESiO2/2; T=R9SiO3/2; TE=RESiO2/2; and Q=SiO4/2; where R1, R2, R3, R4, R5, R6, R7, R8, and R9 are each independently selected from the group of monovalent hydrocarbon radicals RE is a monovalent radical defined as: —R10O—(C2H4O)h(C3H6O)i(C4H8O)i—R11 or —R12 with the provision that the copolymer must contain at least one RE group; R10 is a linear or branched divalent hydrocarbon radical containing from 3 to about 10 carbon atoms; R11 is H or —C(═O)CH3 or a monovalent saturated or unsaturated hydrocarbon radical, optionally containing heteroatoms and hydroxyl groups, containing from 1 to about 30 carbon atoms; R12 is a hydrocarbon radical, containing from 2 to about 30 carbon atoms and at least 1 hydroxyl group, optionally containing heteroatoms; subscripts a, b, c, d, e, f, and g are 0 or positive subject to the limitation a+b+c+d+e+f+g<1000; subscripts h, i, and j are 0 or positive subject to the limitation h+i+j is less than 100; and, b) an organic oil. |
| US08580284B2 |
Oil-based cosmetic preparation
Abstract Provided is an oil-based cosmetic preparation which retains a smooth feel. Provided is an oil-based cosmetic preparation containing the following components (A), (B), and (C): (A) a cellulose derivative having a cellulose skeleton in a main chain, in which 67 mol % or more in total hydroxyl groups are substituted with a group —O-M-R, wherein M represents CH2 or a carbonyl group C═O, and R represents a straight or branched alkyl or alkenyl group having 3 to 40 carbon atoms; (B) an ester oil which is liquid at 25° C.; and (C) a hydrocarbon oil which is liquid at 25° C., in which a weight ratio (B)/(C) of the component (B) to the component (C) is 8/1 to 1/4. |
| US08580280B2 |
Adjuvant compositions
This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals. |
| US08580279B2 |
Compounds
The invention provides BASB082, BASB083, BASB091, BASB092 and BASB101 polypeptides and polynucleotides encoding BASB082, BASB083, BASB091, BASB092 and BASB101 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. |
| US08580277B2 |
Influenza hemagglutinin and neuraminidase variants
Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided. |
| US08580273B2 |
TNF superfamily member light fusion proteins
The present invention refers to fusion proteins comprising a TNF superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a trimerization domain and a nucleic acid molecule encoding the fusion protein. The fusion protein is present as a trimeric complex or as an oligomer thereof and is suitable for therapeutic, diagnostic and/or research applications. |
| US08580270B2 |
Respiratory synctial virus (RSV) sequences for protein expression and vaccines
The invention provides RSV fusion (F) protein ectodomain polypeptide sequences and nucleotide sequences encoding them, as well as cells containing the invention's polypeptide and nucleotide sequences. The invention further provides VLPs that contain the invention's polypeptides, and methods for using the VLPs for protein expression and vaccine formulation. Also provided are methods for distinguishing between subjects immunized with the invention's compositions and subjects infected with RSV. |
| US08580269B2 |
Survivin peptides for autoimmune therapies
Compositions and methods for stimulating an immune response against cells that express survivin are provided. The method is suitable for prophylaxis and/or therapy of autoimmune disorders. The method involves administering to an individual a composition that contains a survivin peptide mimic that has a cysteine to methionine alteration at amino acid position 57 of wild type survivin. Fragments of the peptides can also be used. |
| US08580267B2 |
Immunocytokines for tumour therapy with chemotherapeutic agents
Immunocytokine comprising cytokine, e.g. interleukin 2 (IL-2), conjugated to antibody against tumour neovasculature antigen, e.g. tenascin-C, for use in combination therapy with chemotherapeutic agent such as temozolomide. Use of immunocytokine and chemotherapy for treatment of tumours e.g. glioblastoma and other cancers. |
| US08580266B2 |
Immune modulation via C-type lectin
The invention relates to the regulation of the immune system, and in particular to the finding that the CLEC9a molecule is a marker for dendritic cells which are capable of cross-presenting extracellular antigens via the MHC class I pathway. This makes them particularly suitable for generation of cytotoxic T lymphocyte responses. Materials and methods are provided both for the induction of immune responses against target antigens, and for the inhibition or suppression of undesirable immune responses in which these cells are involved. |
| US08580261B2 |
Methods for prevention and treatment of inflammation using anti-chemokine antibodies
It is possible to inhibit inflammatory processes by administration of antibodies to chemokines. Identification of chemokines which are over-produced makes it possible to block specific chemokine activity using antibodies to the over-expressed chemokines. |
| US08580260B2 |
Method of using anti-IL-13 antibodies
The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma. |
| US08580257B2 |
Antibodies that specifically block the biological activity of kidney associated antigen 1 (KAAG1)
Novel monoclonal antibodies that specifically bind to KAAG1 are described. In some embodiments, the antibodies block the biological activity of KAAG1 and are useful in composition in certain cancers, more particularly in cancers that have increased cell surface expression of KAAG1, such as ovarian, renal, lung, colorectal, breast, brain, and prostate cancer, as well as melanoma. The invention also relates to cells expressing the monoclonal antibodies and antigen binding fragments such as humanized and chimeric antibodies. Additionally, method of detecting and treating cancer using the antibodies and fragments are also disclosed. |
| US08580255B2 |
Method for the treatment of rheumatoid arthritis using a TLR2 antagonistic antibody
The present invention provides compositions and methods for the treatment of autoimmune diseases, in particular rheumatoid arthritis. Compounds which function as antagonists of Toll-like Receptor 2 are shown to suppress the immune response which result in the onset and progression of autoimmune disease. In particular monoclonal antibodies which have a binding specificity to Toll-like receptor 2 are disclosed for use in methods for the treatment and/or prophylaxis of autoimmune disease. |
| US08580254B2 |
Anti-IGF antibodies
Antibody molecules, in particular fully human antibodies that bind to human IGF-1 and cross-react with IGF-2 such that binding of IGF-1 and IGF-2 to the IGF-1 receptor is prevented and IGF-1 receptor-mediated signaling is inhibited. The antibodies do not bind to insulin and thus do not affect the mitogenic properties of insulin that are mediated by its binding to the insulin receptors. The antibodies are useful for the treatment of hyperproliferative diseases, in particular cancer. |
| US08580253B2 |
Immunomodulating compositions and methods of use
This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety. |
| US08580247B2 |
PS-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof
The present invention relates to a method of enhancing the anti-tumor response in a mammal. More particularly, the invention is concerned with combinations comprising a cytokine-secreting cell and an anti-PD-1 antibody, and methods of administering the combination for enhanced immune response to tumor cells in a patient with a cancer. |
| US08580246B2 |
Surfactant-free stable pharmaceutical composition comprising granulocyte-colony stimulating factor
The present invention provides a new stable pharmaceutical composition of granulocyte-colony stimulating factor (G-CSF). |
| US08580241B2 |
Glycerol group-containing organopolysiloxane, cosmetic, and method for producing glycerol group-containing organopolysiloxane
There is disclosed a novel glycerol group-containing organopolysiloxane is formed of a glycerol group-containing substituent shown by the following general formula (1) which is bonded to at least one silicon atom of a main chain organopolysiloxane segment, wherein each X and Y independently represents a divalent hydrocarbon group having 1 to 10 carbon atoms; m represents an integer of 0 to 4; and Z represents an organic group shown by the following general formula (2), wherein Ra represents a divalent hydrocarbon group having 2 to 12 carbon atoms; and m′ represents an integer of 1 to 5. As a result, there is provided a novel glycerol group-containing organopolysiloxane and a method for producing it without requiring special purification processes, and in addition, provided is a cosmetic not generating an odor with passage of time while giving a moist feeling without stickiness. |
| US08580239B2 |
Skin grafting devices and methods
The present invention provides skin grafting and devices that comprise a systematic approach to the process of skin grafting, i.e., harvesting, post-excision processing and application of donor skin and pre and post-graft treatment of the recipient site. |
| US08580236B2 |
Hair sustaining formulation
A multi-dimensional hair sustaining formulation having a liquid transport agent that carries multi-ingredients to hair follicles in order to prevent Dihydrotestosterone (DHT) from attaching to receptor sites on the follicles of existing hair, hence promoting the protection and continued growth of existing hair—which otherwise would succumb to DHT attack and loss—rather than trying to re-grow hair that has already been lost. |
| US08580235B2 |
Hair cosmetic
An object of the present invention is to establish means for reliably incorporating a poorly soluble UV-absorbing agent into a hair cosmetic composition, to thereby provide a hair cosmetic composition which has excellent effect of preventing UV-hair damage and which exhibits favorable sensation in use thereof. Specifically, the object can be attained through provision of a hair cosmetic composition including the following ingredients (1) and (2): (1) a polyoxy(lower alkylene) addition compound represented by formula (I): wherein R represents a phytosterol residue or a phytostanol residue; m is a number from 0 to 100; and n is a number from 5 to 100, and (2) a UV-absorbing agent having a triazine group. |
| US08580233B2 |
Tooth whitening compositions and methods
A method of whitening a tooth surface including contacting the surface of a tooth with an efficacious amount of a substantially non-cytotoxic composition. The non-cytotoxic composition includes chlorine dioxide and no more than about 0.25 milligrams oxy-chlorine anions per gram of the composition. |
| US08580232B2 |
Compositions for enhancing effects of other oral care compositions
An enhancing composition comprising a solvent and a base compound creates an alkaline environment for activating peroxide whiteners and accelerating the formation of free radicals from the peroxide to effect the oxidation of organic molecules causing staining of the dentition. In one embodiment, potassium hydroxide is dissolved in water to form a strongly alkaline liquid. A surfactant may also be included to clean the surfaces of the user's teeth in advance of application of the whitening composition. A peroxide may be added to the enhancing composition to provide a tooth whitening. Other additives for taste, texture, viscosity, and other oral care or oral hygiene purposes may also be included in the enhancing composition. The enhancing composition may be used for advance application to the dentition before a whitening compound. In addition, a rinse may be used after the whitening composition to neutralize the alkaline environment. |
| US08580231B2 |
Compositions and methods comprising magnetic resonance contrast agents
The present invention relates to compositions and methods for imaging with magnetic resonance contrast agents. In particular, the present invention provides targeted contrast agents for selective imaging. |
| US08580230B2 |
Materials and methods for MRI contrast agents and drug delivery
A material useful as a MRI contrast agent used for medical imaging, drug delivery platform or other functions are provided as a class of non-gadolinium and non-iron oxide based materials that comprise Prussian blue materials or analogue materials. The materials may be used as T1-weighted and/or T2-weighted MRI contrast agents for imaging, including cellular imaging, in clinical diagnosis and biomedical research applications. The agent is a compound created from Prussian blue materials that is non-toxic, and can be internalized by cells through endocytosis. The Prussian blue materials may also be used for drug delivery applications. The Prussian blue materials may be administered orally to a subject in either medical imaging or drug delivery applications or dual modality MRI-Fluorescence imaging agent. |
| US08580228B2 |
Treatment of cold start engine exhaust
The present invention relates to a process for reducing cold start emissions in an exhaust gas stream (such as from an internal combustion engine) by contacting the exhaust stream with a combination of molecular sieves comprising (1) a small pore crystalline molecular sieve or mixture of molecular sieves having pores no larger than 8 membered rings selected from the group consisting of SSZ-13, SSZ-16, SSZ-36, SSZ-39, SSZ-50, SSZ-52 and SSZ-73 molecular sieve and having a mole ratio at least 10 of (a) an oxide of a first tetravalent element to (b) an oxide of a trivalent element, pentavalent element, second tetravalent element which is different from said first tetravalent element or mixture thereof and (2) a medium-large pore crystalline molecular sieve having pores at least as large as 10 membered rings selected from the group consisting of SSZ-26, SSZ-33, SSZ-64, zeolite Beta, CIT-1, CIT-6 and ITQ-4 and having a mole ratio of at least 10 of (a) an oxide of a first tetravalent element to (b) an oxide of a trivalent element, pentavalent element, second tetravalent element which is different from said first tetravalent element or mixture thereof. |
| US08580227B2 |
Method for producing hydrogen using block copolymer and oxidation reaction of metals
The present inventions are a method for production of hydrogen which decomposes water into hydrogen by oxidation of metals only when the metals are exposed to the water, while preventing oxidation of pure metal nanoparticles using block copolymers and, in addition, hydrogen produced by the method described above. The method of the present invention has advantages of improved convenience and simplicity, achieves a preferable approach for hydrogen storage because the metal nanoparticles enclosed by the block copolymer have the ease of delivery and reaction thereof. Additionally, the method of the present invention only using water and the metal is considered eco-friendly and useful in industrial energy applications. |
| US08580226B2 |
Synthesis of sodium titanate and ion exchange use thereof
This invention relates to a process for producing a sodium titanate that can be utilized in an ion exchange media. The sodium titanate ion exchange media can be subsequently used to remove contaminants such as metals from water in a variety of applications. The sodium titanate can be synthesized by utilizing a source of titanium that includes a nano-crystalline titanium having a mean primary crystallite diameter of about 1 nm to about 30 nm. |
| US08580225B2 |
Use of hydrophilic organomodified siloxanes as a processing aid for melt granulation
Use of organomodified polysiloxanes which have at least three different polyether radicals, at least two of these polyether radicals differing by at least 9% by mass in the proportion of ethylene oxide units therein in the total weight of the polyether radical, as a release agent or release agent constituent in melt granulation. |
| US08580224B2 |
Method for increasing the sulfuric acid concentration of a sulfuric acid solution
Described is a method of increasing the sulfuric acid concentration of a first aqueous sulfuric acid solution with a sulfuric acid concentration of 82-89% to a concentrated sulfuric acid solution with a sulfuric acid concentration of at least 90%, including evaporating water from the first aqueous sulfuric acid solution in an evaporator vessel to the concentrated sulfuric acid solution, pumping around a mixture of the first aqueous sulfuric acid solution, part of the concentrated sulfuric acid solution, a second aqueous sulfuric acid solution, and hydrogen peroxide through an enameled piping system comprising the evaporator vessel and one or more heaters and pumps, wherein the piping system is operating at a temperature of at least 180° C., and the sulfuric acid concentration of the second aqueous sulfuric acid solution is at least 90%. |
| US08580221B2 |
Chromium (III) carbonate and process for producing the same
The chromium (III) carbonate of the present invention exhibits a light blue color in a solid state. This chromium (III) carbonate has an L* value of 50 to 70, an a* value of −4 to −2, and a b* value of −10 to −7, which are represented by the L*a*b* color system (JIS Z8729). This chromium (III) carbonate is preferably completely dissolved within 30 minutes when the chromium (III) carbonate is added, in an amount corresponding to a Cr content of 1 g, to 1 liter of an aqueous solution of hydrochloric acid having a pH of 0.2 at a temperature of 25° C. This chromium (III) carbonate is preferably obtained by contacting an aqueous solution of carbonate and an aqueous solution containing trivalent chromium at a pH of 6 to 12 under the condition of a reaction liquid temperature of 0° C. or more and less than 50° C. Also, preferably, after production of the chromium (III) carbonate, filtration is performed, and the chromium (III) carbonate is washed with water until the conductivity of the filtrate is 5 mS/cm or less. |
| US08580219B2 |
Ammonium recovery methods
The methods are utilized to recover ammonium from waste water using CO2 acidified absorption water. The process is particularly suited for utilization of cellular matter and a CO2 rich tail gas from a syngas fermentation process and derives significant benefit from the recovery of ammonium bicarbonate and ammonium carbonate. Ammonia and ammonium are recovered from the treatment of the syngas as an ammonium rich solution, at least a portion of which is recycled to the fermentation zone to aid in the production of liquid products. A carbon dioxide rich gas produced by fermentation is used to capture the ammonia and ammonium, forming the ammonium rich solution. |
| US08580215B2 |
Exhaust gas control apparatus and method for internal combustion engine
A NOx selective reduction catalyst for reducing NOx by the ammonia adsorbed is disposed in an engine exhaust gas passage. As states of adsorption of ammonia by the catalyst, there are a first adsorption state of ammonia that occurs when the ammonia is adsorbed during low temperature and a second adsorption state of ammonia that occurs when the ammonia is adsorbed or has already been adsorbed during high temperature. The amount of adsorbed ammonia in the first state is restricted to control concentration of the ammonia that is in the first state and desorbed when the temperature of the catalyst increases so as to be not higher than an allowable concentration, and that in the second state is restricted to control concentration of the ammonia that is in the second state and desorbed when the temperature of the catalyst increases so as to be not higher than an allowable concentration. |
| US08580214B2 |
Emission control system
Methods of treating mercury contaminated gas comprising: introducing a hydrogen halide selected from HBr and HI into a mercury contaminated gas stream containing a quantity of particulate matter at an introduction rate sufficient to create a concentration of at least 0.1 ppmvd; wherein greater than 50% of all particulate matter in the mercury contaminated gas stream is a native particulate matter; contacting a quantity of active bromine with the native particulate matter; creating a doped particulate matter; coating a filtration media with the doped particulate matter; and passing a portion of the mercury contaminated gas stream through the doped particulate matter on the filtration media and other related methods are disclosed herein. |
| US08580212B2 |
Process for preparing trichloroammineplatinate salt and the products obtained therein
The present invention relates to a process for preparing a trichloroammineplatinate salt by reacting a tetrachloroplatinate salt in aqueous solution in the presence of ammonium chloride and an alkali chloride with one or more carbonate salts selected from the group consisting of potassium, sodium and ammonium carbonate while keeping the pH value below 7 during the reaction; the product obtained therein and a use thereof. |
| US08580206B2 |
Purification of carbon dioxide
SO2 and/or NOx are removed from gaseous CO2 at elevated pressure(s) in the presence of molecular oxygen and water and, when SO2 is to be removed, NOx, to convert SO2 to sulfuric acid and/or NOx to nitric acid. The sulfuric acid and/or nitric acid is/are then removed from the gaseous carbon dioxide to produce SO2-free, NOx-lean carbon dioxide gas. The invention has particular application in the removal of SO2 and/or NOx from carbon dioxide flue gas produced in an oxyfuel combustion process, for example, in a pulverized coal fired power station. |
| US08580202B2 |
Slurry phase polymerisation process
A process comprising polymerizing in a loop reactor an olefin monomer optionally together with an olefin commoner in the presence of a polymerization catalyst in a diluent to produce a slurry comprising solid particulate olefin polymer and the diluent wherein the Froude number is maintained at or below 20 is disclosed. |
| US08580201B2 |
Wicking-based reagent-solution draining in an automated system
Embodiments of the present invention include processing steps and subsystems, within automated-biopolymer-synthesis systems and within other automated systems for organic-chemistry-based processing, for removing reagent solutions and solvents from reaction chambers following various synthetic reaction steps and washing steps undertaken during biopolymer synthesis. Embodiments of the present invention employ any of various different types of liquid-absorbing materials to wick, or remove by capillary action, liquids from reaction chambers. Wicking-based methods and subcomponents of the present invention remove significantly greater fractions of solutions from reaction chambers than conventional methods and subsystems and, in addition, are mechanically simpler and produce fewer deleterious side effects than currently used methods and subsystems. |
| US08580200B2 |
Method for label-free multiple analyte sensing, biosensing and diagnostic assay
Methods and systems for label-free multiple analyte sensing, biosensing and diagnostic assay chips consisting of an array of photonic crystal microcavities along a single photonic crystal waveguide are disclosed. The invention comprises an on-chip integrated microarray device that enables detection and identification of multiple species to be performed simultaneously using optical techniques leading to a high throughput device for chemical sensing, biosensing and medical diagnostics. Other embodiments are described and claimed. |
| US08580196B2 |
Automatic analyzer
When a problematic reagent is identified while operating an automatic analyzer, it is required to have a plurality of screens displayed, and it is difficult for inexperienced operators to identify a problematic position of a reagent. With the present invention, control information for reagents and a calibrator required for analysis with an automatic analyzer are displayed concurrently, so that all necessary information can be referred to one screen. In the automatic analyzer according to the present invention, screen switching as required in the conventional technology is not necessary, and improved operability and visibility are provided. |
| US08580195B2 |
Laboratory system for handling sample tube racks, an alignment element for sample tube racks and a rack tray receiver assembly
A laboratory system for handling sample tube racks, an alignment element for sample tube racks and a rack tray receiver assembly are disclosed. The laboratory system to handle laboratory sample tube racks comprises a robotic arm (220) with a gripper (222) for gripping primary racks (PR), wherein the primary racks (PR) to be handled comprise a first end surface (76) and a second end surface (78), the first end surface (76) having a first surface geometry and the second end surface (78) having a second surface geometry, and wherein the gripper (222) comprises a first gripping arm (226) and a second gripping arm (228), with the first gripping arm (226) having a gripping surface being complementary to the first surface geometry, and the second gripping arm (228) having a gripping surface being complementary to the second surface geometry. |
| US08580189B2 |
Stainless steel alloy having lowered nickel-chrominum toxicity and improved biocompatibility
The present invention is directed towards an austenitic, stainless steel series 300 alloy having improved biocompatible characteristics. The modified stainless steel alloy consists essentially of, in weight percent, about CMnSiPS ≦0.030≦2.00≦0.750≦0.023≦0.010 CrMoNiFe“X” 8.5-11.50.0-6.256.5-7.546.185-74.0005.0-10.0 whereby variable “X” could be comprised from a group consisting of Gold, Osmium, Palladium, Platinum, Rhenium, Tantalum, or Tungsten. The alloy provides a unique combination of strength, ductility, corrosion resistance, and other mechanical properties which also has improved biocompatible characteristics. |
| US08580187B2 |
Melt supply pipe for aluminum die casting
There is provided a melt supply pipe comprising a melt supply pipe body composed of an inner ceramic pipe and an outer steel pipe, the outer steel pipe having a Ni alloy layer formed over the inner circumferential surface, and TiC particles attached to the surface of the Ni alloy layer, wherein grooves are formed at both ends of the melt supply pipe body, each groove forming an annular space overlapping the boundary between the outer circumferential surface of the inner ceramic pipe and the inner circumferential surface of the outer steel pipe, and a fibrous sheet of an inorganic material is inserted into each of the annular grooves such that the sheet extends over the entire circumference of the groove. The melt supply pipe is strong to mechanical impact owing to the use of the steel pipe in combination with the ceramic pipe and can prevent intrusion of an aluminum melt despite the difference in thermal expansion between the steel pipe and the ceramic pipe. |
| US08580186B2 |
Flow control apparatus for molten metal
Exemplary embodiments of the invention relate to a flow control apparatus for control of molten metal flow through a trough. The apparatus includes a flow control element (e.g. a movable dam or flow restrictor) movable between an operating position and an inactive position. A guide element provides an elongated track having a first part extending generally parallel to the longitudinal axis of the flow control element. One or more track followers are retained by the guide element and are movable along the track. An elongated arm is attached at one end to the flow control element and to the track follower at an opposite end. An actuator operably connects to the track follower to move the track follower along the track. The track causes the flow control element to move away from the operating position with a straight (non-pivoting) motion, but preferably causes the flow control element to pivot as it approaches the inactive position. The flow control apparatus may be combined with a connector unit for connecting sections of a metal-conveying trough or the like, or may be used directly with such trough or trough sections. |
| US08580183B2 |
Collection tubes apparatus, systems, and methods
Methods of producing collection tubes are presented. The methods include providing a separator substance that can rapidly polymerize in a short time to a desired hardness and disposing the separator substance within the lumen of the tube. The separator substance is formulated to have a density between an average density of a serum fraction of whole blood and a cell-containing fraction of whole blood, and to be flowable with whole blood. Upon centrifugation of a tube having blood, the separator substance forms a barrier between the whole blood fractions. The barrier rapidly hardens forming a solid barrier when triggered by a suitable energy source. |
| US08580181B1 |
Fabrication of three dimensional aligned nanofiber array
Disclosed are methods of forming three dimensional arrays of aligned nanofibers in an open, loose structure of any desired depth. The arrays are formed according to an electrospinning process utilizing two parallel conducting plates to align the fibers and rotating tracks to distribute the fibers throughout the array. Arrays can be used as formed, for instance in tissue engineering applications as three dimensional scaffolding constructs. As-formed arrays can be combined with other materials to form a composite 3-D structure. For instance, composite polymeric materials can be electrospun to form composite nanofibers within the array. Multiple polymeric materials can be electrospun at different areas of the array to form a composite array including materially different nanofibers throughout the array. The arrays can be loaded with other fibrous or non-fibrous materials to form a composite array. Arrays can also be rolled to form a uniaxial fiber bundle. |
| US08580178B2 |
Method and apparatus for forming slats for fabric in coverings for architectural openings
A method and apparatus for forming a transversely curved or formed strip of material which can be cut to length for use in a fabric for coverings for architectural opening includes a supply role of a flexible fabric strip material that is sequentially passed through a heating chamber with an elongated upwardly convex extrusion across which the strip material is drawn and a cooling station before being wrapped on a take-up drum. The apparatus includes driven rollers about which the strip material passes and the strip material is exposed to tension detectors and controlled temperatures such that the strip material formed in the apparatus is uniform along its length. |
| US08580177B2 |
Method for manufacturing a resilient rail support block assembly
A rail support block assembly includes a resilient member and a molded block having a top, a bottom and peripheral wall. The block is adapted for fastening one or more rails on the top. The prefabricated resilient member has an outer tray and inner tray arranged within the outer tray, and includes a resilient intermediate structure between the trays. The block is molded. The block is fixed in the inner tray to extend under the bottom of the block and along a lower region of the peripheral wall. The resilient member may form a part of the block mold, so that a mold member combined with the resilient member delimit the mold for the block. The moldable material is introduced and adheres directly to the inner tray of the prefabricated resilient member. |
| US08580175B2 |
Continuous curing and post-curing method
A method of continuous curing and post-curing of a plurality of extruded strands is provided. A plurality of extruded strands is wrapped through a plurality of spindle units rotatably connected to a rigid frame structure. A plurality of dual spindles are provided in a plurality of upper and lower spindle units, wherein each dual spindle comprises a free spinning roller and a driven roller. A chamber that comprises a dual function chamber configured for heating and cooling is supported on the rigid frame structure. The plurality of extruded strands is continuously transferred between the upper spindle units and the lower spindle units such that the plurality of extruded strands runs in a vertical fashion that continuously alternates between the lower spindle units and the upper spindle units. Each of the plurality of strands is transferred independently of each other and continuously passed through the chamber for continuous curing and post-curing. |
| US08580174B2 |
Method for texturing polymeric films and articles comprising the same
Disclosed herein is a method comprising deforming an organic polymer composition at a temperature below a glass transition temperature of an organic polymer in the organic polymer composition; the deforming being conducted by an application of a shear force, an elongational force, a compressive force, or a combination comprising at least one of the foregoing forces; the forces being applied to the organic polymer composition as it is disposed between a first roll that comprises a rubber surface and a second roll that comprises a textured metal surface; the deforming producing a textured film having a ratio of texturing of about 0.5 to about 3; the textured film having a thickness of about 5 to about 75 micrometers and an average roughness of about 0.3 to about 6 micrometers on opposing surfaces of the film. |
| US08580173B2 |
Assembly and a method for extruding a tire component
In order to facilitate the assembly of a tire component like an Off the Road tire shoulder wedge, it is proposed to extrude this component with a high tack compound coating at its periphery by using a dual extruder which otherwise can extrude the tire component with a first high tack compound coating on one side, combined with an assembly for the extruder comprising a splice bar, a holder and a die which are designed to provide a channel deriving and guiding a portion of the high tack compound of the extruder to the stream of compounds before extrusion through the die, on a side opposite to the first coating, thereby providing a coating at almost the whole periphery of the component. |
| US08580172B2 |
Method and apparatus for providing multiple tile shapes or appearances of same
A method apparatus and product is provided which includes the use of an S-Tile mold, combined with a scoring/knifing process, which allows for subsequent controlled separation of what would normally be an S-Tile into two separate tile sections each having a general C-shaped cross section. This allows for two types of tiles (S-tiles and Two-Piece Mission tiles) to be made from one type of mold (S-tile). A method, apparatus and product is also provided which includes the use of an S-Tile mold, including or combined with a scoring, knifing, or forming process for providing a channel or other suitable shape, which allows for an S-Tile to be produced which appears to be two separate but cooperating tile sections having a general C-shaped cross section. The longitudinal channel 9 or other shape and or proximate area may also be painted, colored, or otherwise darkened in order to accent a “shadow” effect which causes the eye to better perceive separation of the two portions 6 and 7 of the tile 5. A method is also provided which allows for tiles to be broken or not broken depending on the installer's preference. |
| US08580171B2 |
Process for manufacture of a latent heat storage device
A process for the preparation of latent heat storage composites is provided. The process comprises the steps of preparation of an expanded graphite material with a bulk density between 5 and 200 grams/liter which is readily wetted by a liquid phase change material, preparation of a pre-compressed matrix or a packed bed of the expanded graphite material, and manufacture of a latent heat storage composite by infiltration of the matrix or a packed bed with a phase change material in a liquid state. |
| US08580170B2 |
Process for producing a substantially shell-shaped component
Disclosed is a process for producing a substantially shell-shaped component, from substantially carbon-fiber-reinforced synthetic material having at least one local reinforcing zone and at least one stiffening element, in particular a fuselage shell, a wing shell, a vertical stabilizer shell or horizontal stabilizer shell of an aircraft or the like. The process according to the invention comprises the following steps: arranging at least one doubler which has already been cured, on an at most partially cured shell skin to form the local reinforcing zone, applying at least one stiffening element which has already been cured, and placing at least one at most partially cured connecting angle bracket against the at least one stiffening element at least in the region of the at least one doubler, and curing the shell skin and the connecting angle bracket. |
| US08580168B1 |
System and method to account for thermal die expansion
A system and method for effecting die height adjustments of a casting machine, such as to account for thermal die expansion. The system and method finds use on a die casting machine having a driven gear train for causing linear movement of a movable platen thereof. Based on known characteristics of the gears of the gear train and of threaded tie bar nuts upon which the gear train operates, a given rotation of a gear train gear can be converted into a linear movement of the movable platen. A sensor is used to count the teeth of a rotating gear train gear and a controller is provided to correlate the tooth count with a corresponding linear travel distance of the movable platen. |
| US08580163B2 |
Process for manufacturing an ophthalmic lens
There is described a process for manufacturing an ophthalmic lens and an apparatus for forming an ophthalmic lens, in particular a silicone hydrogel contact lens, wherein in a mold assembly a first and a second mold half (101, 102) are first arranged in an intermediate closed position in which the mold surfaces of the two mold halves are spaced apart from each other at a distance increase (d1) of preferably 1 to 100 μm relative to a final distance (d0) in a final closed position, and wherein, during curing of the lens forming material (202), the mold surfaces (105, 106) of the mold halves (101, 102) are actively or passively moved or moving from the intermediate closed position to the final closed position, where the distance increase (d1) is 0. |
| US08580161B2 |
Fluidic devices comprising photocontrollable units
Photochromic materials that are useful for a variety of applications, including for making various unit functions of fluidic devices, particularly microfluidic devices, such as microchannels, valves and gates, using spiropyran materials, such as a polymeric composition comprising a spiropyran. In certain disclosed embodiments the spiropyran is admixed with a polymeric material. For example, the spiropyran may be intercalated into a polyalkylene or polyalkylene phthalate. The spiropyran also may be polymerized with at least one additional monomer to form a heteropolymer, such as by polymerization with styrene, styrene derivatives, acrylate and acrylate derivatives. The spiropyran compositions can be used to make, for example, a photoactuatable valve, a fluidic channel, etc. The valve may be associated with a microchannel, including photochromic microchannel. In certain disclosed embodiments, the valve, at least one microchannel, or both, are re-patternable by light exposure. Embodiments of a method for using a photochromic material in a microfluidic device also are disclosed. One disclosed embodiment concerns providing a microfluidic device comprising at least one re-patternable microchannel defined by a spiropyran photochromic material, at least one photoactuatable valve comprising the same or a different spiropyran photochromic material, or both. Spiropyran photochromic material is serially exposed to light of different wavelengths to move a fluid, to actuate a gate or valve, or both. |
| US08580160B2 |
Algae oil based dielectric fluid for electrical components
The disclosure is directed to a dielectric fluid. The dielectric fluid includes an algae oil. The algae oil includes a natural algae antioxidant. The natural algae antioxidant is selected from β-carotene, astaxanthin, tocopherol, polyunsaturated triglycerides, and combinations thereof. |
| US08580157B2 |
Sulfide and photoelectric element
The sulfide has the following composition, and the photoelectric element uses the sulfide. (1) The sulfide contains Cu, Zn, and Sn as a principal component. (2) When x is a ratio of Cu/(Zn+Sn), y is a ratio of Zn/Sn (x and y being atomic ratios), and the composition of the sulfide is represented by the (x, y) coordinates, with the points A=(0.78, 1.32), B=(0.86, 1.32), C=(0.86, 1.28), D=(0.90, 1.23), E=(0.90, 1.18), and F=(0.78, 1.28), the composition (x, y) of the sulfide is on any one of respective straight lines connecting the points A→B→C→D→E→F→A in that order, or within an area enclosed by the respective straight lines. |
| US08580150B2 |
Submicronic barium and magnesium aluminate phosphors
Submicronic barium and magnesium aluminates, useful as phosphors, are in the form of a liquid-phase suspension of substantially monocrystalline particles having an average particle size ranging from 80 to 400 nm; such aluminates are prepared by a process that includes: providing a liquid mixture containing compounds of aluminum and of other elements that are part of the aluminate composition; drying the mixture by atomization; calcining the dried product in a reducing atmosphere and wet-grinding this product. |
| US08580148B2 |
Phosphor and method for producing same
It is an object of the present invention to provide an alkaline earth metal aluminate phosphor having good heat resistance and durability against vacuum ultraviolet rays and ultraviolet rays, among others, and a method of producing the same.An alkaline earth metal aluminate phosphor containing bivalent europium as an activator, which contains at least one element (e) selected from the group consisting of indium, tungsten, niobium, bismuth, molybdenum, tantalum, thallium and lead. |
| US08580143B2 |
Lyotropic chromonic liquid crystal composition, method for manufacture of lyotropic chromonic liquid crystal coating film, and lyotropic chromonic liquid crystal coating film manufactured thereby
The present invention relates to a lyotropic chromonic liquid crystal composition, a method for manufacturing a lyotropic chromonic liquid crystal coating film and a lyotropic chromonic liquid crystal coating film manufactured thereby. The lyotropic chromonic liquid crystal composition of the present invention includes chromonic liquid crystal compounds and monomers each having opposing acid-base properties. Use of the lyotropic chromonic liquid crystal composition in the formation of optical films leads to improvements in electrical and optical properties such as mechanical strength, an insulating characteristic and a refractive index. |
| US08580142B2 |
Liquid crystal compound, liquid crystal composition and liquid crystal display device
The invention provides a liquid crystal compound having stability to heat, light and so forth, a wide temperature range of a nematic phase, a small viscosity, a suitable optical anisotropy, a suitable elastic constant K33, a suitable and negative dielectric anisotropy, and an excellent compatibility with other liquid crystal compounds. The invention provides a liquid crystal composition containing the compound described above and having stability to heat, light and so forth, a small viscosity, a suitable optical anisotropy, a suitable and negative dielectric anisotropy, a suitable elastic constant K33, a low threshold voltage, a high maximum temperature of a nematic phase, and a low minimum temperature of the nematic phase.The invention also provides a liquid crystal display device having a short response time, a small power consumption, a low driving voltage, and a large contrast, and containing the composition described above which can be used in a large temperature range.For example, a liquid crystal compound having four or more rings in which the central ring has 2,3-difluorophenoxy such as trans-4′-[2,3-difluoro-4-(trans-4-propylcyclohexyl)phenoxymethyl]-trans-4-pentylbicyclohexyl is provided. Further provided is a liquid crystal composition containing the compound, and a liquid crystal display device using this liquid crystal composition. |
| US08580138B2 |
Nanofluids and a method of making nanofluids for ground source heat pumps and other applications
This invention covers nanofluids. Nanofluids are a combination of particles between 1 and 100 nanometers, a surfactant and the base fluid. The nanoparticles for this invention are either pyrogenic nanoparticles or carbon nanotubes. These nanofluids improve the heat transfer of the base fluids. The base fluid can be ethylene glycol, or propylene glycol, or an aliphatic-hydrocarbon based heat transfer fluid. This invention also includes a method of making nanofluids. No surfactant is used to suspend the pyrogenic nanoparticles in glycols. |
| US08580133B2 |
Methods of controlling the etching of silicon nitride relative to silicon dioxide
Disclosed herein are methods of controlling the etching of a layer of silicon nitride relative to a layer of silicon dioxide. In one illustrative example, the method includes providing an etch bath that is comprised of an existing etchant adapted to selectively etch silicon nitride relative to silicon dioxide, performing an etching process in the etch bath using the existing etchant to selectively remove a silicon nitride material positioned above a silicon dioxide material on a plurality of semiconducting substrates, determining an amount of the existing etchant to be removed based upon a per substrate silicon loading of the etch bath by virtue of etching the plurality of substrates in the etch bath and determining an amount of new etchant to be added to the etch bath based upon a per substrate silicon loading of the etch bath by virtue of etching the plurality of substrates in the etch bath. |
| US08580130B2 |
Laser-assisted nanomaterial deposition, nanomanufacturing, in situ monitoring and associated apparatus
Laser-assisted apparatus and methods for performing nanoscale material processing, including nanodeposition of materials, can be controlled very precisely to yield both simple and complex structures with sizes less than 100 nm. Optical or thermal energy in the near field of a photon (laser) pulse is used to fabricate submicron and nanometer structures on a substrate. A wide variety of laser material processing techniques can be adapted for use including, subtractive (e.g., ablation, machining or chemical etching), additive (e.g., chemical vapor deposition, selective self-assembly), and modification (e.g., phase transformation, doping) processes. Additionally, the apparatus can be integrated into imaging instruments, such as SEM and TEM, to allow for real-time imaging of the material processing. |
| US08580127B2 |
Method of manufacturing RFID based thermal bubble type accelerometer
An RFID based thermal bubble type accelerometer includes a flexible substrate, an embedded system on chip (SOC) unit, an RFID antenna formed on the substrate and coupled to a modulation/demodulation module in the SOC unit, a cavity formed on the flexible substrate, and a plurality of sensing assemblies, including a heater and two temperature-sensing elements, disposed along the x-axis direction and suspended over the cavity. The two temperature-sensing elements, serially connected, are separately disposed at two opposite sides and at substantially equal distances from the heater. Two sets of sensing assemblies can be connected in differential Wheatstone bridge. The series-connecting points of the sensing assemblies are coupled to the SOC unit such that an x-axis acceleration can be obtained by a voltage difference between the connecting points. The x-axis acceleration can be sent by the RFID antenna to a reader after it is is modulated and encoded by the modulation/demodulation module. |
| US08580125B2 |
Method and apparatus for control of a gas or chemical
A method and system for control of a gas or chemical. In one embodiment, the system comprises a reactor for receipt of a fluid and the gas and/or chemical for dissolving, mixing, diffusing, or infusing the gas and/or chemical into the fluid, and a controller to control the flow of the fluid and the gas and/or chemical into the reactor. In some embodiments, the system may also monitor the operation of the system in accordance with predetermined operating conditions. In at least one embodiment, the system also comprises a gas/chemical generation system for generation of the gas and/or chemical to be introduced into the reactor. |
| US08580121B2 |
Method for monitoring and controlling a process for treatment of a treatable fluid
The present invention relates to a means of monitoring and controlling a process step, or steps for a treatable fluid being processed, whereby a sampled volume of the treated fluid is delivered to a vessel, within which the sampled treated fluid emulates the expected reaction or reactions of the treatable fluid being processed within the process step. The sampled volume of the treated fluid is detained, monitored, recorded and analyzed by the present invention. The resulting data is translated into commands that are conveyed to process control devices which control the processing of the treatable fluid. Sampling and analyzing of the treatable fluid is automatically repeated on a cyclical basis. |
| US08580119B1 |
Transesterification of biodiesel feedstock with solid heterogeneous catalyst
Process and steps for the production of biodiesel and/or glycerin from feedstock are provided. |
| US08580111B2 |
Device for separating fuel components
A device for separating fuel components comprising a separating membrane for separating high-octane fuel components from un-separated fuel and a heat exchanger between first liquid passing through the heat exchanger and second liquid passing through the heat exchanger, is provided. The first liquid is un-separated fuel passing through the heat exchanger before being supplied to the separating membrane. The second liquid is low-octane fuel remaining when the high-octane fuel components are separated from the un-separated fuel, passing through the heat exchanger after changing to an almost liquid phase. |
| US08580109B2 |
Electronic interface for water filter system
A water filter system includes a filter unit having a body portion adapted to be rotatingly received into a filter head assembly. An engagement protrusion extends from the body portion and is adapted for reception in a complementary receiver in the filter head assembly. An electronic device is disposed on the filter unit having a memory storage unit. A laterally extending key member is disposed on the body portion between the first engagement surface and the second engagement surface. The laterally extending key member is adapted to reposition an interference member from an interference position, whereby the body portion can be fully inserted into the filter head assembly to a non-interference position, whereby the body portion can be fully inserted into the filter head assembly. |
| US08580100B2 |
Metal deposition using seed layers
Methods of forming a conductive metal layers on substrates are disclosed which employ a seed layer to enhance bonding, especially to smooth, low-roughness or hydrophobic substrates. In one aspect of the invention, the seed layer can be formed by applying nanoparticles onto a surface of the substrate; and the metallization is achieved by electroplating an electrically conducting metal onto the seed layer, whereby the nanoparticles serve as nucleation sites for metal deposition. In another approach, the seed layer can be formed by a self-assembling linker material, such as a sulfur-containing silane material. |
| US08580097B2 |
Isotachophoresis of blood-derived samples
Methods are provided for forming a complex comprising an analyte (or an analyte analogue) from a blood-derived sample and labeling substances, and separating the complex from excess labeling substances and coexisting substances from the blood-derived sample, in a rapid, simple, convenient, and highly precise isotachophoresis (ITP) process by adding 2-(N-morpholino)ethane sulfonate (MES) salt and/or glutamate salt to the ITP sample. Methods are also provided for measuring the analyte in blood-derived samples with high precision and high sensitivity, based on the amount of the complex separated or the amount of uncomplexed labeling substance-containing molecules. |
| US08580083B2 |
Device and method for producing a material web
A method to dewater a fibrous web includes directing the fibrous web through a first press zone defined between a revolving permeable belt and a revolving permeable support belt and having a first press zone length. The fibrous web is arranged lying between the revolving permeable belt and the revolving permeable support belt. A fluid is caused to flow through the permeable belt, the fibrous web and the support belt at least over a section of the first press zone length. The fibrous web is dewatered in a second press zone following the first press zone and defined between the revolving permeable belt and the revolving permeable support belt, the second press zone having a second press zone length. The fibrous web is led through the second press zone between the permeable belt and the support belt, the permeable belt and the support belt each having a different compressibility. |
| US08580079B2 |
Electrode carrier assemblies
In accordance with one embodiment of the present disclosure, an electrode carrier assembly is provided including an electrode carrying annulus and a plurality of electrode mounting members. The electrode carrying annulus includes an electrode containment sidewall that forms an inner or outer radius of the electrode carrying annulus. The electrode carrying annulus further includes a plurality of radial sidewall projections that project radially away from the electrode containment sidewall. The radial sidewall projections each include an upward-facing tapered spacer including an upward-facing micro-mesa. The electrode mounting members each include a downward-facing tapered spacer including a downward-facing micro-mesa. The electrode mounting members are rotatably engaged with the electrode carrying annulus, and are configured to rotate between a free position and a bracketed position. |
| US08580076B2 |
Plasma apparatus, gas distribution assembly for a plasma apparatus and processes therewith
A plasma apparatus, various components of the plasma apparatus, and an oxygen free and nitrogen free processes for effectively removing photoresist material and post etch residues from a substrate with a carbon and/or hydrogen containing low k dielectric layer(s). |
| US08580074B2 |
Seam construction method of flexible apparel
A flexible apparel with non-stitch seams and a fabrication method thereof is provided. The non-stitch seams between foamed rubber sheets are sealed by coating a liquid sealant solution containing a thermoplastic polyurethane and a plasticizer. |
| US08580069B2 |
Plastic bonding method
To provide a method of bonding two materials directly with each other, at least one of which is made of a plastic material, which method is applicable to bonding two materials, with no need to use any bonding agent and without allowing the materials to be exposed to high temperature and/or high pressures. In this method in which a first member made of a plastic material and a second member are bonded together, one surface of the first member to be bonded with the second member is irradiated with energy rays having a quantity of energies not lower than 4 eV, followed by directly bonding the first and second members together without any bonding agent being used. |
| US08580066B2 |
Method for manufacturing multilayer wiring substrate
A method for manufacturing a reliable multilayer wiring substrate at a relatively low cost having little or no warpage or distortion is provided. In certain embodiments an insulation core made of an insulation material that is more rigid than that of resin insulation layers is prepared. A through hole is formed through core upper and lower surfaces of the insulation core, and a through hole conductor is formed therein. A plate-like substrate is prepared, and resin insulation layers and at least one conductor layer are laminated on the substrate to form a first buildup layer. The insulation core is laminated on the first buildup layer so as to electrically connect the conductor layer and the through hole conductor. Resin insulation layers and at least one conductor layer are then laminated on the insulation core. Lastly, the substrate is separated from the first buildup layer to yield a multilayer wiring substrate. |
| US08580064B2 |
Process for fastening an accessory to a plastic hollow body during the molding thereof and a connection piece
Process for fastening an accessory to a hollow body obtained by molding a molten plastic parison and using a plastic connector comprising coupling means for the accessory and a stop surface intended to limit the penetration of the connector into the molten plastic, according to which the stop surface is provided with a curved double lip (or one-piece part having two concentric curved edges, i.e., two protuberances located preferably at its periphery, which are concentric and are in relief relative to the remainder of the part) and the connector is welded to the inner wall of the parison using this double lip. |
| US08580063B2 |
Method for producing endoscope flexible tube
A method for producing an endoscope flexible tube comprising the steps of: preparing a flexible tube assembly including a spiral tube formed by spirally winding a metal strip and a cylindrical mesh sleeve, covering the spiral tube, formed by knitting metal wires; covering the flexible tube assembly with an outer coat from one end toward the other end of the flexible tube assembly by using an extrusion molding machine wherein the outer coat has a lower layer formed of a thermoplastic polyurethane elastomer and an upper layer formed of a thermoplastic polyester elastomer and the total thickness of the upper layer and the lower layer is made constant; and annealing the covered flexible tube assembly at a temperature in the vicinity of the softening point of the layer lower in softening point of the upper layer and the lower layer after the step of covering the flexible tube assembly with the outer coat, wherein in the step of covering with the outer coat, the melt viscosity ratio (thermoplastic polyurethane elastomer/thermoplastic polyester elastomer; with reference to the exit temperature of the extrusion molding machine) between the thermoplastic polyurethane elastomer and the thermoplastic polyester elastomer is set to fall within a range from 1 to 35, and the thickness ratio between the upper layer and the lower layer is gradually varied in such a way that one of the upper layer and the lower layer has the maximum thickness at the one end and the one of the upper layer and the lower layer has the minimum thickness at the other end. |
| US08580062B2 |
Apparatus for application of a hook-and-loop fastener component to a turn-up system tear strip
An apparatus and method for securing a hook-and-loop fastener component to the end of a tear strip used in a turn-up operation, the hook-and-loop fastener mechanism provided to secure the end of the tear strip to a rotating component of a spool winding assembly, the apparatus for forming the tear strip assembly having a feed roller, a transfer roller and a press roller, whereby hook-and-loop components presented on a feed tape are adhesively bonded to the tear strip. |
| US08580061B2 |
Apparatus and method for making a corrugated product
The invention describes a device and method for making corrugated products. The device can be used with any substrate and includes, at least, first and second drive rollers for driving a middle substrate and a single wall corrugated product. In other embodiments the invention includes upper drive rollers, lower drive rollers and middle drive rollers for driving an upper substrate, a lower substrate and a middle substrate. The middle substrate is driven between the upper and lower substrates at a higher velocity to form flutes that are anchored between the upper an lower substrates thereby forming a corrugated product. The invention also provides for customized corrugated products having multiple fluted substrates in various desirable arrangements. Examples of such products include mattress, partition panels, other furniture and construction products. |
| US08580058B2 |
Structurally reinforced members
There is disclosed a reinforcement material for forming reinforced members. The reinforcement material includes a strengthening material which is preferably a fabric disposed at least partially between portions of matrix material. |
| US08580056B2 |
Method of making wearing article
A wearing article configured so that loop elements engaged with associated hook elements will not ride up or curl up in the course of the production process. Mount members are attached to an inner sheet in a front waist region so as to extend along first lateral zones of the front waist region and hook elements are attached to a chassis by the intermediary of these mount members. Loop elements are attached to the inner sheet in a rear waist region so as to extend along second lateral zones of the rear waist region. Third regions of the respective mount members are formed with sticking zones operatively associated with outer lateral edges of the respective loop elements. The sticking zones formed on the respective mount members are temporarily joined to the loop elements as the hook elements are engaged with the associated loop elements. |
| US08580054B2 |
Melt-castable energetic compounds comprising oxadiazoles and methods of production thereof
In one embodiment, a melt-castable energetic material comprises at least one of: 3,5-bis(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazole (DNFO), and 3-(4-amino-1,2,5-oxadiazol-3-yl)-5-(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazole (ANFO). In another embodiment, a method for forming a melt-castable energetic material includes reacting 3,5-bis(4-amino-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazole (DAFO) with oxygen or an oxygen-containing compound to form a mixture of at least: DNFO, and ANFO. |
| US08580053B2 |
Ta sputtering target and method for producing the same
A method for producing a Ta sputtering target including the following steps: (a) a step of forging a Ta ingot, comprising subjecting the Ta ingot to a forging pattern over at least 3 times, wherein each forging pattern is “a cold forging step comprising stamp-forging and upset-forging operations alternatively repeated over at least 3 times; (b) an in-process vacuum heat-treating step carried out between every successive two forging patterns to thus prepare a Ta billet; (c) a step of rolling the Ta billet to obtain a rolled plate; and (d) a step of vacuum heat-treating the rolled plate to obtain a Ta sputtering target. A sputtering target produced by the above method. |
| US08580046B2 |
Method for the treatment of a semiconductor wafer
Semiconductor wafers are treated in a liquid container filled at least partly with a solution containing hydrogen fluoride, such that surface oxide dissolves, are transported out of the solution along a transport direction and dried, and are then treated with an ozone-containing gas to oxidize the surface of the semiconductor wafer, wherein part of the semiconductor wafer surface comes into contact with the ozone-containing gas while another part of the surface is still in contact with the solution, and wherein the solution and the ozone-containing gas are spatially separated such that they do not come into contact with one another. |
| US08580043B2 |
Automated cleaning method for an aircraft fuselage interior
An automated cleaning system for an aircraft fuselage interior is provided. The system has a movable assembly designed to fit within an aircraft fuselage interior to be cleaned. The movable assembly has a removable track assembly and an automated transport mechanism mounted on the removable track assembly, the automated transport mechanism being a guided cart that travels on the removable track assembly. The movable assembly further has a manifold and frame assembly mounted on the automated transport mechanism and a fluid dispensing assembly coupled to the manifold and frame assembly for dispensing fluids onto an aircraft fuselage interior surface. The system further has a fluid management system coupled to the movable assembly for supplying the fluids to the fluid dispensing assembly. The system further has a control system that communicates with and controls the movable assembly and the fluid management system. |
| US08580041B2 |
Process for cleaning resin out of an electrical generator parallel ring
A process of cleaning resin out of an electrical generator parallel ring is provided. The process includes inserting a cleaning ball mounted on a shaft into the parallel ring; verifying a location of the cleaning ball; rotating the shaft; measuring a rotational speed of the cleaning ball with a tachometer; and removing resin with the cleaning ball. |
| US08580037B2 |
Method of depositing materials on a non-planar surface
A method of depositing materials on a non-planar surface is disclosed. The method is effectuated by rotating non-planar substrates as they travel down a translational path of a processing chamber. As the non-planar substrates simultaneously rotate and translate down a processing chamber, the rotation exposes the whole or any desired portion of the surface area of the non-planar substrates to the deposition process, allowing for uniform deposition as desired. Alternatively, any predetermined pattern is able to be exposed on the surface of the non-planar substrates. Such a method effectuates manufacture of non-planar semiconductor devices, including, but not limited to, non-planar light emitting diodes, non-planar photovoltaic cells, and the like. |
| US08580031B2 |
Method of producing three-dimensional photonic crystal and optical functional device
A method of producing a three-dimensional photonic crystal by laminating a layer having a periodic structure, the method including the steps of forming a first structure and a second structure each including the layer having the periodic structure; and bonding a first bonding layer of the first structure and a second bonding layer of the second structure. The first bonding layer is one layer obtained by dividing a layer constituting the three-dimensional photonic crystal at a cross section perpendicular to a lamination direction, and the second bonding layer is the other layer obtained by dividing the layer constituting the three-dimensional photonic crystal at the cross section perpendicular to the lamination direction. |
| US08580027B1 |
Sprayed on superoleophobic surface formulations
Fluoroalkylsilane-treated metal oxide particles and a fluoroelastomeric binder are dispersed in a fluorinated solvent with a low boiling point and applied to a substrate via spray deposition. The spray deposition process rapidly produces a conformal coating that features low surface energy and surface topography with a large range of characteristic length scales and re-entrant curvature, thereby imparting superoleophobicity. The degree of superoleophobicity is readily adjusted by means of altering the ratio of particles to binder. The choice of particle and binder result in coatings with thermal stability for thousands of hours at temperatures up to 200 degrees Celsius as well as desirable mechanical characteristics. |
| US08580025B2 |
Ink set, recording method, recorded material and printed material
The ink set includes a yellow ink composition and either a magenta ink composition or a cyan ink composition, or both, wherein a coloring agent of the yellow ink composition is one which includes an azo pigment represented e.g. by the following formula or its tautomers or their salts or hydrates, the magenta ink composition contains as a coloring agent at least one pigment selected from the following: C.I. Pigment Violet 19, C.I. Pigment Red 122, C.I. Pigment Red 202 and C.I. Pigment Red 209, and the cyan ink composition contains as a coloring agent at least one pigment selected from the following: C.I. Pigment blue 15:1, C.I. Pigment Blue 15:2, C.I. Pigment Blue 15:3, C.I. Pigment Blue 15:4 and C.I. Pigment Blue 15:6. |
| US08580024B2 |
Inkjet ink compositions comprising modified pigments
The present invention relates to an inkjet ink composition comprising a liquid vehicle and a modified pigment, which comprises the reaction product of a non-modified pigment and at least one reagent having the formula H2N-A-Y. The modified pigments themselves, as well as methods for preparing them, are also described. |
| US08580023B2 |
Run-safe filter system
A run-safe filter system is provided for confirming installation of a qualified filter element in a housing. An electrical switch has a first electrical condition in response to a qualified filter element being installed in the housing, and a second electrical condition in response to the absence of a qualified filter element installed in the housing. |
| US08580021B1 |
Portable air scrubber device
The portable air scrubber device provides for removably covering an existing chimney with the chimney cap. The axial fan forces airflow through the device hoses, removable filters, flex joints, and tank. The hose flex joints allow adaptation to various chimneys and roofs. The device may be disassembled into its various components such as the hoses, the fan housing, the chimney cap, the flex joints, and the tank components, thereby aiding portability. Liquid filtration media used for filtration may include water, water and glycol mix, and other additives that aid in air filtration and particulate removal. Air once passed through the filters and sprayed by the liquid filtration media may exit the top section holes. Excessive liquid filtration media may also exit the top section holes. |
| US08580017B2 |
Electrostatic precipitator
An electrostatic precipitator including a charger to charge dust particles in air and a collector to collect the dust particles. The collector includes a collector case including high-voltage electrodes, to which high-voltage is applied, low-voltage electrodes alternately stacked with the high-voltage electrodes so as to be grounded, and first electrode support elements to support the high-voltage and low-voltage electrodes with a distance therebetween. The first electrode support elements include electrode contact terminals to support extreme edge portions of the high-voltage and low-voltage electrodes. The high-voltage and low-voltage electrodes are formed of a conductive material, or a non-conductive material, the surface of which is subjected to conductive treatment. The electrode contact terminals for the high-voltage electrodes are formed of a semiconductive material. Accordingly, it is possible to maintain a constant distance between the electrodes and to prevent insulation breakdown without deterioration in the performance of the collector. |
| US08580010B2 |
Desiccant air-conditioning system and operating method thereof
A dew point temperature sensor detects and sends the dew point temperature of the supply air to a dry area, as a supply air dew point temperature, to a controller. The controller has a speed of rotation of the regenerating side fan (the regenerating air flow rate) to control, and determines a control value (the regenerating air flow rate) that causes the supply air dew point temperature to go to a target dew point temperature, and determines a supply air processing pre-cooling coil exit temperature setting value in accordance with this control value (where if the control value is in the direction of reducing the regenerating air flow rate, the supply air processing pre-cooling coil exit temperature setting value is increased). Note that what is controlled is the speed of rotation of the desiccant rotors, or the exit temperatures of the air heated by the hot water coils. |
| US08580009B2 |
Honeycomb filter
There is provide a honeycomb filter which can suppress generation of cracks in plugged portions due to heat generated by burning of a PM during regeneration and comprises a honeycomb basal body including porous partition walls arranged to form a plurality of cells disposed in parallel with one another and including inflow cells and outflow cells which are formed adjacent to the inflow cells; first plugged portions with which one end of each of the inflow cells is plugged; second plugged portions with which another end of each of the outflow cells is plugged; porous collecting layers formed on the inflow-cells side surfaces of the partition walls; and end aggregate layers made of a particulate aggregate material and formed on the inflow-cells-side surfaces of the first plugged portions, and a thickness of the end aggregate layers is from 0.5 to 5 mm. |
| US08580008B2 |
Vertical filtering and separating suction machine of chips, steam and smoke by change of air direction, for machining center, lathe machine or other machines generating steam from oil or coolant
The invention hereby disclosed is a vertical filtering and separating suction machine of chips, steam and smoke for machining center, lathe machine or other machines, which operates by sudden changes of sucked air, thus generating hits which separate heavy particles, whose suction pipe extends almost up to the bottom of the rotor, which only uses filters at the end of the process of air purification, whose rotor has outer paddles modified in order to improve suction power and to cause more hits of air flow, and which includes an air pressure alarm showing the filter is saturated. |
| US08580006B2 |
Filter lock and seal system
The present concept a filter lock and seal system for sealing a filter assembly to a tubesheet includes a filter assembly which includes filter media mounted between top and bottom end caps. The top end cap includes an annular seat portion extending longitudinally from the top of a lower flange and terminating at an annular radial outward projecting shoulder. The filter assembly further includes a snap band for sealing the filter assembly to the tubesheet and cooperatively seating against the annular seat portion. Wherein the snap band including a cavity and a deformable portion for engaging with a tubesheet end. |
| US08580005B2 |
Tractor cab air filter housings
A tractor cab filter housing (20) has at least one air intake (20a) through which air is drawn into the housing, an outlet (20c) through which air leaves the housing, a filter element (18) positioned between the inlet and outlet, and an opening access door (21) through which the filter element can be accessed for servicing/replacement. The housing access door (21) includes an integral storage chamber (21f) in which liquids or other items can be stored. The housing door is a hollow plastics molding having an access opening (21d) through which liquid can be introduced into the storage chamber, the opening having a cap (21e) for closing of the opening. A pump (50) may be provided for pumping the liquid out of the storage chamber. |
| US08580004B1 |
Unitary filter cartridge with flow transition mouth
A high efficiency unitary cartridge filter for installation with a separate sealing gasket in a generally uniform circular or oblong hole of a baghouse tube sheet. The cartridge includes a plastic or metal tubular core around which is wrapped elongate pleated filter media to form a pleat pack. The pleat pack is sealed at the lower end thereof by a molded cap. A molded upper fitting includes an aerodynamically contoured transition mouth comprising compound radii of curvatures and a bore which closely corresponds to the bore of the tubular core for improved cleaning power and increased pressure during a cleaning cycle and for reduced pressure drop during normal filtering operation. The molded top may optionally incorporate and bond with a metal collar for added structural integrity and may also incorporate electrical grounding elements for grounding a metal core to the baghouse tube sheet. |
| US08579999B2 |
Method of enhancing the quality of high-moisture materials using system heat sources
The present invention harvests and utilizes fluidized bed drying technology and waste heat streams augmented by other available heat sources to dry feedstock or fuel. This method is useful in many industries, including coal-fired power plants. Coal is dried using the present invention before it goes to coal pulverizers and on to the furnace/boiler arrangement. Coal can be intercepted on current coal feed systems ahead of the pulverizers. Drying fuel, such as coal, is done to improve boiler efficiency and reduce emissions. A two-stage bed utilized in the process first “pre-dries and separates” the feed stream into desirable and undesirable feedstock. Then, it incrementally dries and segregates fluidizable and non-fluidizable material from the product stream. This is all completed in a low-temperature, open-air system. Elevation of fan room air temperature is also accomplished using waste heat, thereby making available to the plant system higher temperature media to enhance the feedstock drying process. |
| US08579997B2 |
Systems and methods for producing engineered fuel feed stocks from waste material
Systems and methods for producing engineered fuels from solid waste material are described herein. In some embodiments, a method includes receiving a waste stream at a multi-material processing platform and separating the waste stream to remove non-processable waste and marketable recyclables. The method further includes conveying processable materials to a material classification system and incorporating additives to produce an engineered fuel from the constituents of the waste stream. |
| US08579996B2 |
Process and apparatus for converting organic matter into a product
A process for treating organic matter to convert it into a product comprises the step of contacting the organic matter with supercritical liquid whereby it reacts to form the product. The liquid may be heated by an external heating medium, or may be heated internally of the process by co-feeding an oxidising agent with the liquid. This agent can be in an amount that is predetermined to control the extent to which the reaction mixture is heated. The heat can be supplied to provide sufficient activation energy for the process reaction to occur with sufficient speed and for the liquid to attain sufficient characteristics to cause the reaction. |
| US08579995B2 |
Method for forming a thin-film lithium-ion battery
A method for forming an integrated lithium-ion type battery, including the successive steps of: forming, on a substrate, a stack of a cathode layer made of a material capable of receiving lithium ions, an electrolyte layer, and an anode layer of the battery; forming a short-circuit between the anode and cathode layers; performing a thermal evaporation of lithium; and opening the short-circuit between the anode and cathode layers. |
| US08579994B2 |
Method for producing a solid-state cell and a solid-state cell
A method for producing a solid-state cell which makes it possible to produce a highly reliable solid-state cell that suppresses a decrease in the thickness of the solid electrolyte layer and a short circuit between the positive and negative electrodes, and which is highly flexible in the size and shape of the solid electrolyte layer and electrodes. The method comprising: a structure preparing step for preparing a first structure, a second structure, or a third structure, a solid electrolyte material powder layer, and a positive electrode material powder layer are stacked, in this sequence; an insulating member disposing step for disposing a heat-resistant insulating member which is in contact with an outer periphery of the structure in the stacking direction of the structure and surrounds the outer periphery; and a heat-compressing step for heat-compressing the structure and heat-resistant insulating member, in the stacking direction of the structure. |
| US08579992B2 |
Hair dye
It is an object of the present invention to provide a safe hair dye, which has a good dyeing property and is easy-to-use, and which has less uneven dyeing and has high stability of the formulation. The present invention provides a hair dye which comprises a combination of (1) a first gel agent containing tannic acid, benzyl alcohol and xanthane gum, and (2) a second agent containing an iron salt. |
| US08579990B2 |
Tissue repair devices of rapid therapeutic absorbency
Novel implantable tissue repair medical devices are disclosed. The devices have a central fabric member having anti-adhesion films on both opposed sides. The films have pores, and are arranged such that the pores on the opposed films are offset. The devices are useful in hernia repair procedures. |
| US08579981B2 |
Expanding interbody implant and articulating inserter and method
A device to space vertebral members with first and second members that may have at least one ramped section. The first and second members may be positioned in a vertically overlapping arrangement with interior sides of the members facing together. The device may be positionable between a first orientation with the ramped section of the first member positioned away from the ramped section of the second member, and a second orientation with the ramped section of the first member positioned against the ramped section of the second member. The device may include a greater height measured between the exterior sides in the second orientation than in the first orientation. |
| US08579974B2 |
Method for drilling angled osteal tunnels
Methods for drilling an angled osteal tunnel into a bone by drilling or punching at least one first tunnel portion into the bone from a first surface location on the bone, the at least one first tunnel portion having an interior end within the bone and then drilling or punching at least one second tunnel portion into the bone from a second surface location on the bone using a guide component to guide a drill to the interior end of the first tunnel portion, whereby the at least one first tunnel portion and the at least one second tunnel portion intersect and connect at an angle, resulting in an angled osteal tunnel. |
| US08579973B2 |
Eustachian tube device
A device stenting the Eustachian tube is inserted through the nasopharynx and provides enhanced ventilation and drainage to the middle ear. Also provided is a method for inserting the device into the Eustachian tube and through the isthmus of a human subject. |
| US08579969B2 |
Dual mode automated intraocular lens injector device
An IOL injector device allows for both powered and manual delivery of an IOL. The injector has a tubular housing. A plunger is longitudinally disposed within the housing and has first and second ends. The first end is disposed towards the front end of the housing. A drive system is coupled to the housing. The drive system causes longitudinal translation of the plunger along the primary axis of the housing. A normally engaged clutch system is coupled to the drive system. The normally engaged clutch system allows manual disengagement of the drive system. A knob coupled to the plunger allows for manual operation of the injector. |
| US08579966B2 |
Prosthetic valve for transluminal delivery
A prosthetic valve assembly for use in replacing a deficient native valve comprises a replacement valve supported on an expandable valve support. The valve support, which entirely supports the valve annulus, valve leaflets, and valve commissure points, is configured to be collapsible for transluminal delivery and expandable contact the anatomical annulus of the native valve when the assembly is properly positioned. Portions of the valve support may expand to a preset diameter to maintain coaptivity of the replacement valve and to prevent occlusion of the coronary ostia. |
| US08579964B2 |
Transcatheter mitral valve prosthesis
A prosthetic cardiac valve comprises an anchor having an atrial skirt, an annular region, and a ventricular skirt. The prosthetic valve also has a plurality of prosthetic valve leaflets each having a first end and a free end. The first end is coupled with the anchor and the free end is opposite the first end. The prosthetic cardiac valve has an open configuration in which the free ends of the prosthetic valve leaflets are disposed away from one another to allow antegrade blood flow therepast, and a closed configuration in which the free ends of the prosthetic valve leaflets engage one another and substantially prevent retrograde blood flow therepast. The anchor has a collapsed configuration for delivery to the heart and an expanded configuration for anchoring the prosthetic cardiac valve to a patient's heart. |
| US08579961B2 |
Sectional crimped graft
The present invention provides a sectional crimped graft that allows graft flexibility where required and limits the overall longitudinal extension. The present invention overcomes the disadvantage of fully crimped grafts by controlling the number of crimps per unit length, crimp height, crimp geometry and their location along the graft wall, dependent on the particular end-use application. In so doing, flexibility and elongation can be controllably tailored only in areas where significant anatomical angulation is present. It may also be useful in applications other than stent grafts such as surgical grafts for aortic and peripheral areas. Limiting the overall graft longitudinal extension also facilitates the deployment of the stent-graft into the blood vessel. |
| US08579959B2 |
Radiopaque reinforcing member
A reinforcement member (10) for a fenestration in a stent graft (30) comprises a composite wire (12) formed from wire strands of at least two types (14, 16, 18). A first type of wire strand comprises a metal alloy with shape memory characteristics and a second type of wire strand comprising a metal with radiopaque characteristics. The first type of wire strand and the second type of wire strand are twisted or braided together to form the composite wire and then formed into the circular ring with at least two turns of the composite wire forming the ring. The reinforcement member can be a circular ring mounted into a fenestration (40) in a wall (32) of a stent graft, or mounted around a stent graft, or it can be a substantially U-shaped edging along the edge of a scalloped fenestration (44). |
| US08579949B2 |
Provisional fixation for a multi-axial screw assembly
A multi-axial screw assembly comprises a receiver, a base member, a crown and a bone screw. The base member includes an aperture extending through the base member and an opening on a bottom portion of the base member. The base member is rotatable relative to the receiver and has an inner wall extending partially around the aperture. The crown is received in the receiver and configured to mate to the base member. The crown has a projection configured to extend into the opening of the base member. The projection is configured to have an abutting surface. The bone screw is located between the base member and the crown, the bone screw is configured to be provisionally fixed within the receiver by a force between the abutting surface of the projection and the inner wall of the base member. |
| US08579946B2 |
Anatomical distal radius fracture fixation plate
A fixation plate includes a set of threaded peg holes adapted to individually receive fixation pegs therethrough and non-threaded alignment holes having a relatively smaller diameter than the peg holes and preferably sized to closely receive a K-wire. The alignment holes are located between the peg holes. One peg hole is configured for aligning the plate during an osteotomy procedure, while other peg holes are configured for use after fracture reduction and receive K-wires to temporarily secure the plate to the bone and determine whether pegs inserted through adjacent respective peg holes will be properly located before drilling relatively larger holes for such pegs. |
| US08579945B2 |
Bone stabilization device
A bone plate for the stabilization of bones includes upper and lower surfaces extending along a central longitudinal axis. The lower surface is configured to contact a target portion of bone when in an operative configuration a through opening extending through the plate from the upper surface to the lower surface. The through opening is sized and shaped to receive a stabilization plate. The through opening has an elongated curved shape selected to conform to a cross-sectional shape of a proximal portion of the stabilization plate. |
| US08579944B2 |
Bone plate with suture loops
A bone plate and method of forming a bone plate having a plurality of suture loops pre-attached to the bone plate. The suture loops may be flexible and formed of a strong suture material. The suture loops may have various shapes, forms and configurations and may be provided on the bone plate in any number, depending on the characteristics of the fractured bone or bone segments, or of the plate design. Preferably, the suture loops are attached to a surface of the bone plate. The suture loops may receive a strand of suture for fixation of soft tissue to the bone plate. |
| US08579938B2 |
Staple for use in surgical procedures
A staple is provided having a backspan and a first and second legs extending distally from the backspan. Each of the first and second legs includes a bend dividing each leg into a traversing leg portion and a substantially linear clenching leg portion. A staple plate is positionable over the first and second legs between the backspan and the first and second clenching leg portions. An anvil assembly has first and second movable members which move toward to one another to engage outer surfaces of the first and second clenching leg portions. There is further disclosed a method of forming the staple through tissue. |
| US08579937B2 |
Tool member cover and cover deployment device
A surgical instrument including a tool member cover and a cover deployment device are disclosed. The cover is supported adjacent to or on the tool assembly of the surgical instrument and is movable from a first position in which the tool assembly is uncovered to a second position in which the tool assembly is at least partially encompassed by the cover. The deployment device is provided for moving the cover from the first position to the second position. |
| US08579936B2 |
Centering of delivery devices with respect to a septal defect
A system for treating a septal defect having an implantable treatment apparatus and devices for delivering the implantable treatment apparatus, devices for controlling delivery of the treatment apparatus and methods for treating a septal defect are provided. The implantable treatment apparatus is preferably implantable through a septal wall or portion thereof. The treatment system can include a flexible elongate body member, a delivery device configured to deliver the implantable apparatus, and a proximal control device for controlling delivery of the implantable apparatus, among others. |
| US08579930B2 |
Surgical instrument and method of use for releasing soft tissue
A surgical instrument for use in releasing soft tissue within the human body. The surgical instrument has a handle with proximal and distal ends with a tube connected to the distal end. The surgical instrument also includes a blade member that slidingly engages the tube moving along the length of the tube to cut soft tissue. Further included in the surgical instrument is a guard member that is attached to the blade member. The guard member has a hood portion and a capture portion. The hood portion is connected to the blade member with the distally positioned capture portion acting to displace surrounding tissue while capturing certain soft tissue structures resulting in the blade member being in operative position to cut and release the soft tissue. A surgical instrument kit including a plurality of modular surgical instruments and method for releasing soft tissue using the surgical instrument are also disclosed. |
| US08579919B2 |
Surgical helical fastener with applicator
A helical fastener having a high retentive surface area is provided and has a first end for enhancing penetration into tissue and a second end comprising a coil sectioning a diameter of the fastener for receiving longitudinal and rotational forces. The helical fasteners are attached to body tissue by a fastener applicator having a proximal portion comprising a handle and an actuator and an elongate distal portion for housing a plurality of fasteners. A transferring action of the actuator provides longitudinal and rotational movement of the fasteners out of the distal portion and into body tissue. |
| US08579917B1 |
Surgical staple remover with removable front end
A surgical staple remover apparatus includes a handle located at a rear of the apparatus, a housing having an interior volume and a distal opening, and an insert element located in the distal opening, wherein the insert element comprises at least two sidewalls and an upward sloped jaw element comprising a pair of parallel jaws. The apparatus includes an arm having a hook element and a lever mechanically coupled to the arm, wherein moving the lever closer to the handle results in the hook element pressing against a crown of a surgical staple, deforming the surgical staple for removal and moving the surgical staple towards the rear. The surgical staple remover apparatus further includes a strip element, such that when the hook element moves the surgical staple towards the rear, the surgical staple is moved under the strip element and held in place by same. |
| US08579913B2 |
Drive assembly for facilitating deployment of an implantable medical device
A driver assembly (50) for an introducer assembly (10) for the deployment of an implantable medical device (16) includes a sprung element (52) coupled to a yoke (56). The yoke (56) is coupled to a gripper element (58). The yoke (56) is coupled to a first handle unit (30) of the introducer (10). The sprung element (52) is coupled to a proximal handle unit (32). A brake element (66) acts to prevent operation of the sprung element (52) when no manual force is being applied to attract a sheath (24) and the assembly (10). When manual retraction force is applied to the assembly (50) the gripper element (58) the brake element (66) releases a sprung element (52) so that the lighter can apply a force assistance to assist in the retraction of the sheath (24) and thereby to assist in the deployment of a medical device. |
| US08579912B2 |
Sacroiliac joint fusion alignment guide
A device and method for defining a trajectory for instruments in a sacroiliac joint fusion procedure employs a handle and two movable guidance arms that are separated by an adjustable distance. The first guidance arm has a substantially straight pronged distal end terminating in a first prong, a second prong and a space between the first prong and second prong defining a first point in a straight trajectory for inserting screws into a sacroiliac joint. The guidance arm forms a receiving bore on a distal end thereof to define a second point in the trajectory. The pronged distal end is inserted through a posterior incision in the patient into a cored-out sacroiliac joint, with the second guidance arm outside the body, and the orientation of the alignment guide is adjusted by pivoting the alignment guide about the pronged distal end to determine a suitable trajectory. Instruments and implements are placed along the trajectory and guided by the alignment guide to drill screw holes and insert screws used in the sacroiliac joint fusion procedure into the screw holes. |
| US08579911B2 |
Instruments and methods for inserting artificial intervertebral implants
Apparatus and methods for preparing a disc space and inserting an intervertebral disc implant therein are disclosed. Among the various instruments disclosed are a midline marker, a reference pin drill and insertion guide, a fin drill guide, a chisel guide, a sizer, a serrated broach, an implant dispenser, and an implant insertion tool. Methods of utilizing these tools are also disclosed. |
| US08579910B2 |
Insertion blade assembly and method of use
A spinal implant insertion device is hereby provided. The device includes an insertion blade assembly having a set of opposed insertion blades wherein the assembly is adapted to slide from a retracted position to an extended position relative to an elongate shaft. In the extended position, a blades are adapted to be positioned above and below a portion of a spinal implant so as to shield the portion of the implant during delivery to an intervertebral space. The insertion blades assembly can also be modular so as to utilize a wide range of distinct insertion blades. Additionally, a method for delivering a spinal implant to an intervertebral space is herein provided. Like above, the method utilizes an insertion blade assembly adapted to slide along a shaft of a spinal implant insertion device. |
| US08579909B2 |
Methods and instrument for vertebral interbody fusion
Methods and instrumentation particularly adapted for disc space preparation for insertion of implants from an anterior approach to the spine are provided. The instruments include a guide sleeve defining a channel having overlapping cylindrical working channel portions and lateral non-distracting extensions extending from reduced thickness wall portions. The guide sleeve has an overall reduced width configuration. A pair of distractors are provided. A first distractor includes a shaft and distal tip, each having convex walls. A second distractor includes a shaft and distal tip including a recessed area at least along the tip. The first distractor is at least partially received within the recessed area of the second distractor when the first and second distractors are in side-by-side relation and a reduced overall width of the distractors is obtained. Preferably, the first and second distractors are used with the guide sleeve. Methods using the disclosed instruments are also provided. |
| US08579906B2 |
Apparatus and measuring instrument
An apparatus and measuring instrument includes a first part and a second part slidably moveable with respect to one another. The first part includes a locking member that has a hard portion which is movable from a first position to a second position. The second part includes a compressible portion that has a Shore hardness less than the hard portion and is positioned such that when the locking member is in the first position the compressible portion is not engaged by the hard portion, and when the locking member is in the second position the compressible portion is at least partially compressed by the hard portion thereby preventing relative movement of the first and second parts. |
| US08579897B2 |
Bipolar forceps
In various surgical techniques, a bipolar forceps can be used to seal a vessel in two locations such that the vessel can be incised at a location positioned intermediate the two seal locations. The bipolar forceps can include a cutting element which can be configured to incise the vessel. In various embodiments, the cutting element can include a sharp edge which can be moved relative to the vessel. In at least one embodiment, the cutting element can be electrically connected to a source of energy. The bipolar forceps can include first and second electrodes positioned within first and second jaw members, respectively, wherein at least one of the jaw members can include a substantially tapered profile and can be configured to pull the vessel away from the surrounding soft tissue. Such jaw members can include ridges, teeth, and/or a textured outer surface configured to grip the soft tissue and/or vessel. |
| US08579895B2 |
Method of and apparatus for positioning and maintaining the position of endoscopic instruments
The present invention provides an apparatus for, and a method of, accurate positioning of endoscopic instruments. Accurate positioning of the instruments is accomplished through the inclusion of a steering ability within the device. After the endoscopic instrument is properly positioned, the present invention may use rapid exchange technology, soft locks, and mechanical locks to maintain the position of the endoscopic instrument. Rapid exchange technology is used to minimize displacement forces present on the guidewire or catheters. Soft locks and mechanical locks resist movements caused by displacement forces. |
| US08579888B2 |
Medical probes for the treatment of blood vessels
Devices and methods for thermally-mediated treatment of blood vessels to elicit an immune response to cause rapid endothelial growth over at least portions of an implant or stent to prevent adverse events such as restenosis. Devices and methods for thermally-mediated treatment to inhibit contraction of vessels to elicit an immune response to cause rapid endothelial growth over at least portions of a stent to prevent adverse events such as restenosis. |
| US08579885B2 |
MEMS electrochemical bellows actuator
An implantable fluid delivery system may include a fluid reservoir configured to hold a supply of fluid, dispense that fluid under the control of an actuator, and be implanted within the body of a living host. The actuator may include a bellows configured to expand in a direction when inflated. The bellows may have folds with surfaces which run substantially perpendicular to the direction of expansion in a collapsed state and which define a stacked set of convolutions. Each convolution may have a collapsed height of no more than 1 mm and a width perpendicular to the direction of expansion of no more than 8 mm. Electrodes may be configured to come in electrical contact with an electrolyte within the bellows and to cause electricity to run through the electrolyte, thereby causing the electrolyte to break down into a gas and, in turn, to cause the bellows to expand. |
| US08579884B2 |
Infusion pump assembly
A wearable infusion pump assembly includes a reservoir for receiving an infusible fluid, and an external infusion set configured to deliver the infusible fluid to a user. A fluid delivery system is configured to deliver the infusible fluid from the reservoir to the external infusion set. The fluid delivery system includes a volume sensor assembly, and a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the volume sensor assembly. The volume sensor assembly is configured to determine the volume of at least a portion of the quantity of fluid. The fluid delivery system further includes at least one optical sensor assembly configured to sense the movement of the pump assembly, a first valve assembly configured to selectively isolate the pump assembly from the reservoir, and a second valve assembly configured to selectively isolate the volume sensor assembly from the external infusion set. |
| US08579882B1 |
Cannula system
The present disclosure provides a cannula useful for introducing a thermally responsive polymer in situ. In embodiments, the cannula possesses more than one cannula, with the thermally responsive polymer introduced in one cannula, and a material such as a coolant in a second cannula which prevents premature gelling of the thermally responsive polymer. |
| US08579881B2 |
Single operator exchange biliary catheter
Catheter for use in biliary procedures, including a shaft having a proximal end and a distal end. A guidewire lumen is carried by the shaft extending from a location proximal the distal end of the shaft to a location proximate the distal end of the shaft. An opening is included for accessing the guidewire lumen from a location exterior the catheter shaft located distal the proximal end of the shaft. The guidewire lumen may be formed integral the catheter shaft. The catheter may be used in rapid exchange catheter procedures. The catheter may further include a port and channel design including a first opening into the guidewire lumen located proximal the distal end of the shaft, a second opening located proximal the first opening, and a channel extending longitudinally between the first opening and the second opening. |
| US08579876B2 |
Tucked fastener for improved fastener performance
A folded disposable absorbent garment has an absorbent chassis, a pair of front side panels extending from a front region of the absorbent chassis, and a pair of back side panels extending from a back region of the absorbent chassis. A first fastening component is disposed on each of the front side panels and a second fastening component is disposed on each of the back side panels. Each of the second fastening components is releasably attached to a respective one of the first fastening components to define a pair of refastenable seams. The front side panels and the back side panels are folded such that each of the refastenable seams overlies an outer surface of one of the front region and the back region of the absorbent chassis in a plane generally parallel to the front and back regions of the absorbent chassis. |
| US08579870B2 |
Sealing valve assembly for medical products
A sealing valve assembly is provided for medical products. The valve assembly includes a valve member mountable within a passageway of a medical product body element, the valve member defining a peripheral portion spaced from a central axis and including two walls extending from the peripheral portion toward the central axis. The walls include ends that contact each other to preclude flow through the passageway. The valve member may be formed of a material having a durometer of less than about 20 Shore A. The valve member may also have a higher durometer material with other wall configurations, or may have a wall member having a varying durometer. |
| US08579865B2 |
Hazardous agent injection system
Injection systems comprising a powered injector and one or more hazardous agents are disclosed. |
| US08579862B2 |
Applicator for microneedle array
Provided is a microneedle device which protects microneedle, has an easily portable shape, is free from such problems as breakage of small needles in the step of puncturing the skin with the microneedle, and ensures appropriate skin puncture for administering a drug. By studying the relationship between a device to be pressed to the skin and the height of an elevation on the skin surface under the pressing and thus producing a device equipped with microneedle that are embedded in a concave part having a definite depth, the microneedle can be surely and easily inserted and punctured into the skin while avoiding such problems as breakage of the small needles of the microneedle. Thus, a microneedle patch formulation, which is easily portable and ensures convenient drug administration to the skin, can be produced. |
| US08579852B2 |
Apparatus and methods for repairing tissue defects
Methods and devices to process harvested skin tissue and to immediately reintroduce the ground tissue into the patient to repair a tissue defect are disclosed. A hand-held portable tissue grinder comprising a housing and a grinding element are disclosed. The tissue grinder is used for grinding skin and subcutaneous tissue and includes a sterile polymer housing having a first opening adapted to receive the skin and subcutaneous tissue. The tissue grinder also includes a sterile grinding element disposed substantially within the housing. The grinding element includes a plurality of cutting surfaces adapted to operably engage with the housing to provide ground tissue and further includes a handle mechanism coupled to the grinding element to move the grinding element with respect to the housing to grind the skin and subcutaneous tissue, wherein the ground tissue can be removed from the housing. |
| US08579844B1 |
Traction device and associated method for increasing intervertebral space and lengthening the spine
A therapeutic traction device for increasing intervertebral spaces along a cervical spine of a user includes a user interface, a controller, a neck rest section, a crossbar provided with first and second clamps, a curvilinear back pad connected to an anterior side of the crossbar, and a utility box connected to a posterior side of the crossbar. The utility box includes a rectilinear driven rod partially seated within the utility box and statically mated to the neck rest section, and a mechanism for linearly reciprocating the driven rod along a first vertical travel path defined posterior of the back pad such that the neck rest section is synchronously raised and lowered above the crossbar. In this manner, the back pad remains statically mated to the crossbar while the neck rest section is raised and lowered along a second vertical travel path defined anterior of the first vertical travel path. |
| US08579840B1 |
Spring fingers massager
A massager has a base and a shaft mounted horizontally on the base. The shaft is rotated by a motor at a slow speed. The shaft has a plurality of spaced apart cams affixed to it. Elongate spring fingers are each affixed at one end to the base. Each finger has an intermediate portion that springably engages one of cams. A free end of the finger moves up and down as the cam rotates. The free end is provided with a projection that is suited to engage a body part. The projection is periodically pressed against the body as the cam rotates. The cams are mounted on the shaft so that they raise and lower the projections as different times. This action causes the projections to each press against the body at different times to emulate massaging fingers. |
| US08579838B2 |
Multi-sensor signal processing system for detecting walking intent, walking supporting apparatus comprising the system and method for controlling the apparatus
Provided is a walking supporting apparatus for supporting a user walking by using a multi-sensor signal processing system that detects a walking intent. A palm sensor unit detects a force applied to a palm through a stick to generate a palm sensor signal. A sensor unit detects a force applied to a sole through the ground to generate a sole sensor signal. A portable information processing unit checks a user's walking intent by using the palm sensor signal, and if it is checked that the user has a walking intent, the portable information processing unit generates a driving signal in response to the sole sensor signal. A walking supporting mechanism includes a left motor attached to a user's left leg and a right motor attached to a user's right leg to support the user's walking when the left and right motors are driven in response to the driving signal. |
| US08579834B2 |
Display of detected patient posture state
The disclosure provides a system that displays an indicator of patient posture state that changes according to posture state data. The posture state data may be transmitted from a medical device, for example, in or near real-time. In some examples, the disclosure relates to a method comprising receiving posture state data for a patient from a medical device; and presenting an indicator indicative of two or more of posture states based on the received posture state data, wherein each posture state of the two or more posture states is determined based on different detection criteria. |
| US08579828B2 |
Managing preload reserve by tracking the ventricular operating point with heart sounds
A system and method for managing preload reserve and tracking the inotropic state of a patient's heart. The S1 heart sound is measured as a proxy for direct measurement of stroke volume. The S3 heart sound may be measured as a proxy for direct measurement of preload level. The S1-S3 pair yield a point on a Frank Starling type of curve, and reveal information regarding the patient's ventricular operating point and inotropic state. As an alternative, or in addition to, measurement of the S3 heart sound, the S4 heart sound may be measured or a direct pressure measurement may be made for the sake of determining the patient's preload level. The aforementioned measurements may be made by a cardiac rhythm management device, such as a pacemaker or implantable defibrillator. |
| US08579827B1 |
Monitoring device with an accelerometer, method and system
A monitoring device for monitoring the vital signs of a user is disclosed herein. The monitoring device is preferably comprises an article, an optical sensor, an accelerometer and processor. The optical sensor preferably comprises a photodetector and a plurality of light emitting diodes. A sensor signal from the optical sensor is processed with a filtered accelerometer output signal from the accelerometer to create a filtered vital sign signal used to generate a real-time vital sign for a user. |
| US08579824B2 |
Method and apparatus to monitor change in inspiratory effort using intrathoracic blood pressure waveform morphology
An implantable medical device and associated method detect obstructed inspiration by monitoring an blood pressure signal. A respiration signal is monitored and a phase of respiratory inspiration is detected from the respiration signal. A trend in the pressure signal is measured during the inspiration phase. Obstructed inspiration for the inspiration phase is detected in response to the measured the trend. |
| US08579820B2 |
Fetal heart monitoring
A transmit amplifier (12) drives an ultrasound transducer (11) to emit a pulse, and a receive amplifier (13) amplifies the echo signal detected by the transducer. The receive amplifier's gate opens a fixed delay after the end of the transmit pulse, and a demodulator (14) multiplies the received signal by the local oscillator signal. A low-pass filter removes the sum of the frequencies and passes the difference of the frequencies (the received signal's Doppler frequency) to be digitized by an ADC. ADC readings are made for each of several range bins in intervals during the receive gate-open interval. One or two of the Doppler audio signals will contain the signal from the fetal heart. When a periodic signal is found, its rate is tested to see if it lies within or outside the typical range of a fetal heart. |
| US08579818B2 |
Ultrasonic diagnostic apparatus
An ultrasonic diagnostic apparatus includes an ultrasonic diagnostic apparatus body, a support member provided in the ultrasonic diagnostic apparatus body to support the ultrasonic diagnostic apparatus body on an installation surface, a movable body provided in the ultrasonic diagnostic apparatus body in a movable state by a moving member while protruding from the ultrasonic diagnostic apparatus body in a direction away from the ultrasonic diagnostic apparatus body, and a tipping-preventing support member provided in the ultrasonic diagnostic apparatus body and having a support portion able to support the ultrasonic diagnostic apparatus body on the installation surface on the protruding side of the movable body with respect to the support member. |
| US08579813B2 |
Handheld personal data assistant (PDA) with a medical device and method of using the same
A medical device module for use in a system with a remote programmer and/or a personal data assistant (PDA) with at least one medical device includes a housing, at least one medical device and a processor. The housing is adapted to couple with the PDA. The at least one medical device interface is coupled to the housing for interfacing with the at least one medical device. The processor is coupled to the at least one medical device interface to process data from the at least one medical device. The processor is also capable of interfacing with the PDA. |
| US08579811B2 |
Medical diagnosis derived from patient drug history data
In general the invention is directed to systems, methods, and/or software modules which may analyze a patient's drug history, and optionally other data, and derive a probable diagnosis for the patient based on rules. |
| US08579810B2 |
Expandable thoracic access port
A surgical access assembly includes first and second wings disposed in opposed relation relative to one another. Each wing includes a body portion, a distal portion and first and second portions. A side wall section hingedly connects the body portions of the wings to one another at the first portion thereof and at the second portions thereof. Each of the side wall sections is movable with respect to the other side wall sections between a first position and a second position wherein each of the side wall sections is angled with the first and second wings. The first and second wings are moveable between an approximated position corresponding to the first position of the side wall sections and a spaced apart position corresponding to the second position of the side wall sections. |
| US08579809B2 |
Radially expanding surgical retractor
A radially expanding surgical retractor which includes a base having a thickness, the base having a first slot extending through the thickness in a first arc, and a second slot discrete from the first slot and extending through the thickness in a second arc. The radially expanding surgical retractor further includes a first handle, a second handle, a first blade extending through the first slot and connected to the first handle, and a second blade extending through the second slot and connected to the second handle. |
| US08579808B2 |
Tensioning device of a surgical retractor
A tensioning device of a surgical retractor has a tensioning section for applying a tensile force to a tool that is to be arranged thereon, and a holding bar fixed in position relative to the tensioning section, and also a locking device. The locking device is provided between the holding bar and the tensioning section and has a releasable locking function counter to the direction of the tensile force. The tensioning device can be operated comfortably, with minimal force being applied, is optimally accessible and takes up only a small overall volume. This is made possible by the fact that the locking device is configured as a linear ratchet or linear feed mechanism and that the feed mechanism has an actuating lever and an unlocking device. |
| US08579804B2 |
Variable length nephrostomy sheath
An adjustable sheath assembly sized to accept a medical instrument and adapted for insertion into a body of a patient for maintaining a passageway therein. The device includes a first hollow member having a first length, and a second hollow member having a second length, the first and second members being coaxially joined together through a length adjustment element. At least one of the first and second hollow members is sized to accept a medical instrument. The length adjustment element allows for the length of the sheath assembly to be fitted to bodies of various sizes by adjusting the length prior to insertion into the patients body. A properly adjusted length ensures that at least a portion of the sheath assembly remains outside of the patient's body. |
| US08579803B2 |
Endoscope
An endoscope includes an insertion portion including an image pickup section, an illumination section, and a light guide inserted inside the insertion portion, the light guide including a plurality of fibers made of a glass not containing lead, the plurality of fibers guiding illuminating light from a light source apparatus to the illumination section, the light guide having a numerical aperture of 0.46 to 0.90. A core glass of a fiber have a refractive index nd of 1.56 to 1.74, and a composition of (A) 20 to 55 wt % SiO2, (B1) 0 to 4.0 wt % B2O3, (B2) neither P2O5 nor GeO2 contained, (C) 25 to 72 wt % (BaO+SrO+La2O3+Lu2O3+Ta2O5+Gd2O3+WO3), (D) 0 to 30 wt % ZnO, (E) no Al2O3 contained, (F) no ZrO2 contained, (G) neither PbO nor As2O3 contained, (H) 0 to 15 wt % (Na2O+K2O), (I) 0 to 0.050 wt % Sb2O3 and (J) 0.26 to 1.63 wt % (Na2SO4+K2SO4). |
| US08579801B2 |
Endoscope riveted deflection section frame
An endoscope deflection section frame including a plurality of rings and rivets. Each ring has front ears and rear ears with rivet holes through the ears. The rivets are located in the rivet holes to thereby pivotably connect the rings to one another. Each rivet includes a head at an interior side of an inner one of the ears and an opposite end at an exterior side of an outer one of the ears. The opposite end is welded to the outer ear. |
| US08579799B2 |
Electronic endoscope system, processor for electronic endoscope, image search system, and image search method
In a search mode of an electronic endoscope system, ordinary light images and special light images are captured from a body cavity respectively under white light and special light. Simultaneously, biological information on the body cavity is acquired from image signals obtained under the special light. The ordinary and special light images are associated with the acquired biological information and stored in an image accumulator. By pressing a lock-on switch while confining a target in an area designating frame on an ordinary image on a monitor, the target is designated and biological information on the target is determined. Thereafter, biological information associated with the latest image in the image accumulator is compared with the biological information on the search target. If the latest image contains an area having the same biological information as the search target, the area designating frame is displayed on that area on the monitor. |