Document Document Title
US08575392B2 Charge-transporting varnish
A charge-transporting varnish comprising a phenylamino-N,N′-diphenylquinonediimine derivative represented by the formula (1) as a charge-transporting substance. It becomes possible to provide a charge-transporting varnish comprising an oxidized oligoaniline, which has a high solubility in various organic solvents and also has a good filtration property because the varnish has no aggregation property. (wherein R1 represents a hydrogen atom or a substituted or unsubstituted monovalent hydrocarbon group; and R2 to R19 independently represent a hydrogen atom, a hydroxyl group, an amino group, a silanol group, a thiol group, a carboxyl group, a phosphoric acid group, a phosphate ester group, an ester group, a thioester group, an amide group, a nitro group, a substituted or unsubstituted monovalent hydrocarbon group, an organooxy group, an organoamino group, an organosilyl group, an organothio group, an acyl group, a sulfone group or a halogen atom.)
US08575383B2 Silsesquioxane compound having polymerizable functional group
To provide a composition comprising a silsesquioxane compound that is capable of producing a coating film with excellent heat resistance and scratch resistance, and that has excellent compatibility with general polymerizable unsaturated compounds as well as polymerizable unsaturated compounds with high polarity.A silsesquioxane compound comprising organic groups each directly attached to a silicon atom of the compound, at least one of the organic groups being an organic group having one or more urethane bonds and one (meth)acryloyloxy group.
US08575382B2 Low molecular weight pharmacological activity modulators
Claimed are a compound of the general formula (I) and pharmaceutically acceptable salts thereof, where M signifies metal atoms selected independently from the group comprising Pd, Fe, Mn, Co, Ni, Cu, Zn and Mo; R1 and R2, independently of each other, signify hydrogen, amino, hydroxy, oxy, carboxy, cyano, C1-12alkyl, C2-12alkenyl, C2-12alkynyl, C1-12alkoxy, C1-12alkylamino, C1-12alkoxycarbonyl, C1-12alkylamido, arylamido, wherein the alkylene groupings in the given substituents can in turn be substituted by one or more of the following groups: hydroxy, oxy, carboxy, amino or amido; R3-R10, independently of each other, signify hydrogen; or NHR3R4 and NHR5R6, taken together, and/or NHR7R8 and NHR9R10, taken together, are a ligand (or ligands) containing one or several donor aliphatic or aromatic atoms of nitrogen and being in cis position on the metal atoms (M). The claimed compound can be used in a preparation containing a coordination compound and free molecules of an aliphatic thiol (or derivatives thereof), which are not bound to the coordination compound. The coordination compound and the free molecules of an aliphatic thiol (or derivatives thereof) in the preparation can be in either cationic or anionic form or in the form of neutral particles. The proposed substances are capable of making the action of drugs more effective by increasing the affinity of the target to the drug and/or providing for therapeutically optimal concentrations of the drug in the microenvironment of the target and/or reducing the toxicity of drugs.
US08575381B2 Trihydridosilyl-terminated polysilanes and methods of preparation
Novel trihydridosilyl-terminated polysilanes and methods for their synthesis, which are applicable to other polysilanes, are provided. The synthetic methods provide for facile preparation of products with minimal handling of pyrophoric intermediates and byproducts. The novel compounds contain at least three silicon-silicon bonds and at least one terminal silicon atom having three hydrogen substituents.
US08575377B2 Synthesis of long-chain polyunsaturated fatty acids by recombinant cell
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids.
US08575375B2 Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties
This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
US08575374B1 Ionic liquids processing of biomass to reducing sugars and other dehydration products
The present invention describes the use of an ionic liquid acid catalyst for the hydrolysis of cellulose into reducing sugars and other degradation products. The use of an ionic liquid catalyst for the hydrolysis of cellulose provides a low volatility catalyst and eliminates the hazards associated with the handling of mineral acids. Conditions such as temperature, catalyst modification, and ionic liquid solvent control the production of reducing sugars and other products. The combination of using an ionic liquid as the solvent for cellulose and ionic liquid catalyst provides an unprecedented tunability of the reaction properties giving more control over the conversion process to produce dehydration products with higher yields depending on the desired feedstock.
US08575358B2 Oxazolidinium compounds
Oxazolidinium compounds are formed by the reaction of a halohydrin or an epoxide with a secondary amine and an aldehyde or a ketone. The oxazolidinium compounds are formed directly and do not require the reaction of a pre-formed oxazolidine with an alkylating agent. The compounds are useful as gas hydrate inhibitors in oil and gas production and transportation. The oxazolidinium compounds have the structure: where R is a saturated or unsaturated alkyl group containing from 3 to 20 carbon atoms, where R has an absence of aryl groups; R1 and R2 each independently have 1 to 20 carbon atoms, may be linear, branched or cyclic; linear, branched or cyclic groups having 1 to 20 carbon atoms substituted with alkyl groups, aryl groups, alkylaryl groups, and aryl groups substituted with alkoxy groups, and X is selected from the group consisting of chlorine, fluorine, bromine or iodine.
US08575355B2 Di-thiazolyl-benzodiazole based sensitizers and their use in photovoltaic cell
Described herein are D-π-A type sensitizers of the formula (I) or (II) having a novel central π-conjugated unit di-thiazolyl-benzodiazole and dye-sensitized electrodes including a substrate having an electrically conductive surface, an oxide semiconductor film formed on the conductive surface, and the above sensitizer of formula (I) or (II), as specified above, supported on the film. A solar cell includes the above electrode, a counter electrode, and an electrolyte deposited there between. The sensitizers of formula (I) and (II) efficiently sensitize the semiconductor materials and show a high solar to electricity conversion efficiency.
US08575354B1 Fused thiophenes and methods for making and using same
Disclosed are compounds having one of the following formulae: wherein X is an aromatic nucleophilic substitution leaving group; R1 is hydrogen, an alkyl group, or an aryl group; and Q1 is a carboxyl protecting group or an aldehyde protecting group. Also disclosed are fused thiophenes that can be prepared using these compounds, as well as stannylthio-containing thiophene, thienothiophene, and dithienothiophene compounds that can be used to prepare fused thiophenes. Methods for making and using the aforementioned compounds, fused thiophenes, and stannylthio-containing thiophene, thienothiophene, and dithienothiophene compounds are also disclosed.
US08575353B2 Compounds for the treatment of addiction
Disclosed are novel compounds having the structure of Formula (I): which are useful for treating a human for dependence upon substances of addiction, for example addiction to a dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and/or alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of a compound of Formula (I) and methods of using the compounds of Formula (I) in the treatment of addiction to a dopamine-producing agent.
US08575349B2 Derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids and their uses as cooling compounds
The present invention relates to novel derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids represented by Formula I: wherein n is an integer of 1 or 2; R1, R2, R3, and R4 are each independently selected from the group consisting of hydrogen and methyl; X is selected from the group consisting of oxygen and nitrogen; and R5 is hydrogen or a C1-C7 linear or branched acyclic hydrocarbon group, or R5 together with X form a 3- to 8-membered heterocyclic hydrocarbon group, and their uses as cooling compounds.
US08575346B2 Ruthenium based complexes
The present invention relates to the field of catalysis and, more particularly, to a ruthenium carbonate complex of formula [Ru(diene)(C03)] or [Ru(diene)(C03)2]Mn, wherein M is an alkaline (n is 2) or alkaline earth (n is 1) cation. The invention relates also to the use of said ruthenium carbonate complex as precursors for a number of Ru carboxylate complexes. Said specific ruthenium complexes possess a number of important advantages over the similar prior art known precursors.
US08575344B2 Process for preparing voriconazole by using new intermediates
Provided is a process for preparing Voriconazole represented by Chemical Formula 1. More particularly, the process for preparing Voriconazole of Chemical Formula 1 includes: carrying out the Reformatsky-type coupling reaction between a ketone derivative of Chemical Formula 4 and a pyrimidine derivative of Chemical Formula 5 to obtain a compound of Chemical Formula 3; reacting the substituents halo and oxysulfonyl with a hydrogen donor to obtain racemic Voriconazole of Chemical Formula 2; and carrying out optical isolation of the racemic Voriconazole by adding an adequate optically active acid thereto to obtain Voriconazole having high optical purity with high cost-efficiency and high yield.
US08575343B2 Process for the preparation of a propenal intermediate and derivatives thereof
The present invention provides an improved process for the preparation of (E)-N-(4-(4-fluorophenyl)-6-isopropyl-5-(3-oxoprop-1-enyl)pyrimidin-2-yl)-N-methyl methanesulfon-amide, which is a useful intermediate for the preparation of (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl methylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxy hept-6-enoic acid, commonly known as Rosuvastatin.
US08575342B2 HIV inhibiting 5-heterocyclyl pyrimidines
Compounds of formula (I), N-oxides, pharmaceutical acceptable salts, quaternary amines or stereoisomeric forms thereof, and their use as HIV replication inhibitors, In the formula, -a1=a2-a3=a4- and -b1=b2-b3=b4- may be —C═C—C═C—; X1 may be O, NR1, etc.; R1, R2, R2a, R3, R4 and R5 are assorted substituents as defined in the specification.
US08575341B2 Cosmetic composition, cosmetic treatment method, and compound
The invention relates to a cosmetic composition, particularly for hair care, and to a method for cosmetically treating keratin material, particularly the hair, using the compounds of Formula (I), where: —n=1, 2, 3, or 4; —R1, R′1, R2, and R′2 are H, —OH, —NRR′, or a C1-C18 carbon group capable of containing one or more heteroatoms selected from among O, S, and N; and —Z is a multivalent carbon radical optionally substitutable and/or interruptible by specific groupings, it being understood that said radical Z includes at least one heteroatom selected from among N, O, and S.
US08575340B2 Purine derivatives and their pharmaceutical uses
The present invention relates to compounds of formula (I): wherein; R1 represents hydrogen or C1-3alkyl; n is an integer having a value of 1 to 5; X represents O or NH; Y represents C or N; or a pharmaceutically acceptable salt thereof, have been shown to be inducers of human interferon and may possess an improved profile with respect to known inducers of human interferon, for example enhanced potency. The compounds of the invention may therefore be useful in the treatment of various disorders, in particular the treatment of infectious diseases, cancer, allergic diseases and other inflammatory conditions, and their use as vaccine adjuvants.
US08575339B2 Derivatives of erlotinib
This invention relates to novel compounds and hydrochloric acid salts thereof. More specifically, this invention relates to novel compounds and hydrochloric acid salts thereof derived from erlotinib. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering an epidermal growth factor receptor tyrosine kinase (EGFR) inhibitor, such as erlotinib.
US08575336B2 Indazoles
The present invention relates to compounds of formula (I): to pharmaceutically acceptable salts therefore and to pharmaceutically acceptable solvates of said compounds and salts, wherein the substituents are defined herein; to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly asthma and COPD.
US08575329B2 siRNA targeting kinase insert domain receptor (KDR)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for KDR.
US08575328B2 Formicidae (ant) control using double-stranded RNA constructs
Disclosed is a dsRNA construct that relates to a method to control Formicidae (ants) via double-stranded RNA interference of the PBAN/Pyrokinin gene.
US08575327B2 Conserved HBV and HCV sequences useful for gene silencing
Conserved consensus sequences from known hepatitis B virus strains and known hepatitis C virus strains, which are useful in inhibiting the expression of the viruses in mammalian cells, are provided. These sequences are useful to silence the genes of HBV and HCV, thereby providing therapeutic utility against HBV and HCV viral infection in humans.
US08575324B2 Methods and reagents for molecular detection of HIV-1 groups M, N and O
Reagents and assays for detecting HIV-1 groups M and O and optionally HIV-1 group N and SIVcpz are provided. The reagents are nucleic acid primers for the hybridization to, amplification and subsequent detection of HIV-1 groups M, N and O and SIVcpz in a biological sample. The primers are oligonucleotides that selectively hybridize to the highly conserved regions of the env and pol regions of HIV-1. Due to the high sensitivity of the assays, small concentrations of HIV in a biological sample can be detected, allowing diagnosis at an early stage of infection. The assays are qualitative or quantitative and are useful for viral load determinations of HIV-1 groups M, N or O in a patient undergoing treatment for HIV-1 infection. Viral load determinations can be used to monitor the progress of the treatment regimen, the development of drug resistance, and to predict disease progression.
US08575320B2 Compositions and methods for separating, characterizing and administering soluble selenoglycoproteins
The invention relates to soluble selenium compositions and methods of production, separation and purification thereof. In particular the present invention provides methods of preparing water soluble selenoglycoproteins (e.g., via extracting selenoglycoproteins from selenium enriched yeast), methods of supplementing a selenium deficient composition via admixing water soluble selenoglycoproteins with the selenium deficient composition, compositions comprising the water soluble selenoglycoproteins and methods of administering the same.
US08575319B2 Cleavable vaccine compositions and uses thereof and methods of making and using the same
The invention relates to methods for making vaccines using linkages that are cleavable under lysosomal processing conditions, and vaccine compositions obtained therefrom. In some embodiments, the vaccines comprise a tumor antigen, an immunogenic carrier and a linker covalently linking the tumor antigen and the immunogenic carrier by a thio ether linkage. Vaccines of preferred embodiments can be used against a cellular proliferative disease that is characterized by the tumor antigen.
US08575318B2 Hepatocyte growth factor (HGF) binding proteins
The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
US08575317B2 Anti-NR10 antibody and use thereof
The present inventors successfully obtained anti-NR10 antibodies having an effective neutralizing activity against NR10. The anti-NR10 antibodies provided by the present invention are useful as, for example, pharmaceuticals for treating or preventing inflammatory diseases.
US08575314B2 Antibody against oxidized LDL/β2GPI complex and use of the same
From antibodies that can be used to immunostain atherosclerotic tissue sections, the present inventors selected antibodies applicable to in vivo imaging, and analyzed their specificities. The result showed that fluorescently labeled anti-oxidized LDL/β2GPI complex antibodies that are specific to a particular epitope were effective for imaging.
US08575310B2 Bioactive pentapeptides from rice bran and use thereof
In general, the invention relates to novel bioactive pentapeptides from heat stabilized defatted rice bran having anti-cancer, anti-obesity, anti-Alzheimer and other health-promoting activities proteins. The bioactive pentapeptides can be incorporated into pharmaceutical, nutraceuticals and food compositions having at least the bioactive pentapeptide as an active ingredient.
US08575309B2 Delta-opioid receptor selective analgesics
Methods and materials are provided for the production of glycosylated peptides that exhibit high affinity and specificity for delta opioid receptors. The methods and materials of the present invention may be used for treatment of conditions involving pain, such as acute pain and nociceptic pain, neuralgia and myalgia.
US08575308B2 Method for cancer immunotherapy
A novel compound of the formula (1): wherein X is a tyrosine residue or a methionine residue; Y and Z each are a single bond or the like; R1 is a hydrogen atom or the like; R2 is a hydroxy group or the like; R3 is a hydrogen atom, alkyl group, amino group or the like; R4 is a hydrogen atom, alkyl group, carboxy group or the like; m is 1 or 2; and n is an integer of 0 to 2, with the proviso that when n is 0, R3 is a hydrogen atom or an alkyl group, or a pharmaceutically acceptable salt thereof, and its use in cancer immunotherapy.
US08575304B2 MEK ligands and polynucleotides encoding MEK ligands
The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate MEK activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
US08575299B1 Processes for preparing diacids, dialdehydes and polymers
Alcohols are catalytically oxidized to aldehydes, in particular to benzaldehyde and diformylfuran, which are useful as intermediates for a multiplicity of purposes. The invention also relates to the polymerization of the dialdehyde and to the decarbonylation of the dialdehyde to furan.
US08575298B2 Polyether ether ketone, and method for purification of polymer material
A polyether ether ketone that is superior in mold flow performance, mechanical physical properties, and thermal stability is provided. A polyether ether ketone having a repeating unit represented by the formula: —Ar—C(═O)—Ar—O—Ar′—O— (wherein, Ar and Ar′ represent a substituted or unsubstituted phenylene group), the polyether ether ketone including: (A) a polymerization component having a molecular weight of not lower than 5,000 and lower than 2,000,000; and (B) a polymerization component having a molecular weight of not lower than 1,000 and lower than 5,000, wherein: the weight ratio of (A):(B) is 60:40 to 97:3; the content of (C) a polymerization component having a molecular weight of not lower than 100 and lower than 1,000 is from 0 and less than 0.2% by weight based on the total weight of the component (A), the component (B) and the component (C); and the polyether ether ketone exhibits a multimodal molecular weight distribution with a maximum peak molecular weight falling within the range of not lower than 5,000 and lower than 2,000,000.
US08575295B2 Glow-wire resistant polyamides
Thermoplastic molding compositions comprising A) from 29 to 97.5% by weight of a thermoplastic polyamide, B) from 1 to 20% by weight of melamine cyanurate, C) from 0.5 to 10% by weight of an organic phosphorus compound based on 9,10-dihydro-9-oxa-10-phosphaphenanthrene oxide (DOPO) as parent structure, D) from 1 to 50% by weight of a fibrous filler, the aspect ratio (L/D) of which is from 4 to 25, and the arithmetic average fiber length of which is from 40 to 250 μm, and E) from 0 to 50% by weight of further additives, where the total of the percentages by weight of components A) to E) is 100%.
US08575287B2 Method for producing polytetrafluoroethylene fine powder
To provide a method for producing a PTFE fine powder having a low paste extrusion pressure property by a simple method. The method for producing a PTFE fine power comprises emulsion polymerizing tetrafluoroethylene in the presence of an aqueous medium, a fluorinated surfactant and a radical polymerization initiator, to produce an aqueous PTFE emulsion, and coagulating it in the presence of at least one bulk density-reducing compound selected from the group consisting of ammonia, an ammonium salt and urea in an amount of from 0.4 to 10 parts by mass per 100 parts by mass of PTFE.
US08575285B2 Catalyst for living radical polymerization
Provided is a catalyst used for a living radical polymerization method, which contains a central element consisting of carbon and at least one halogen atom binding to the central element. Further, a hydrocarbon compound can be used as a catalyst precursor. A monomer having a radical-reactive unsaturated bond is subjected to a radical polymerization reaction in the presence of the catalyst, consequently a polymer having narrow molecular weight distribution can be obtained, and thus the cost of the living radical polymerization can be remarkably reduced. The present invention is significantly more environmentally friendly and economically excellent than conventional living radical polymerization methods, due to advantages such as low toxicity of the catalyst, low amount of the catalyst used, high solubility of the catalyst, mild reaction conditions, and no coloration/no odor (no need of any post-treatments for a molded article), and the like.
US08575280B2 Thermosetting resin composition, thermosetting resin composition solution, film forming material and their cured product
Disclosed is a thermosetting resin composition including; (A) a carboxyl group-containing polyurethane prepared by using (a) a polyisocyanate compound (b) polyol compounds (c) a carboxyl group-containing dihydroxy compound as raw materials, (B) a curing agent, wherein the polyol compounds (b) are one or more kinds of polyol compound(s) selected from Group (I) and one or more kinds of polyol compound(s) selected from Group (II); Group I: polycarbonate polyol, polyether polyol, polyester polyol, and polylactone polyol, Group II: polybutadiene polyol, polysilicone having terminal hydroxyl groups, and such a polyol that has 18 to 72 carbon atoms and oxygen atoms present only in hydroxyl groups. The thermosetting resin composition can give a protection film for flexible printed circuits that has excellent long-term reliability of electric insulation, flexibility, and low warpage from curing shrinkage, and particularly low tackiness.
US08575279B2 Method for preparation of polyolefins containing exo-olefin chain ends
The present invention is directed to a method for preparation of polyolefins containing exo-olefin chain ends. The method involves quenching a cationic quasi-living polyolefin polymer system with a nitrogen-containing five-membered aromatic ring having at least two hydrocarbyl substituent compounds attached to the ring.
US08575278B2 Ionomer compositions for golf balls
Certain disclosed embodiments of the present invention concern a golf ball including a core having a center, an outer cover layer, and optionally one or more intermediate layers. At least one or more of the core, outer cover layer or one or more intermediate layers includes a sulfonated polyisoprene ionomer having the general formula: where A is an isoprene repeating unit having the formula —(CH2—C(CH3)═CH—CH2)—, B is an isoprene repeating unit or other monomer repeating unit, m is greater than 10, and n is greater than 2, and X is selected from one or both of the following groups; i) Li+, Na+, K+, Zn2+, Ca2+, Co2+, Ni2+, Cu2+, Pb2+, and Mg2+ or ii) an ammonium cation having the general formula [NR1R2R3R4]+. R1, R2, R3 and R4 are selected from one or both of the following hydrogen, a C1-C20 aliphatic, cycloaliphatic or aromatic moiety.
US08575276B2 Biomimetic compounds and synthetic methods therefor
Synthesis methods for creating polymeric compounds comprising dihydroxyphenyl derivatives (DHPD), or DHPp i.e. polymers modified with DHPD, with desired surface active effects are described. The polymer backbone of DHPp has structural or performance features that can be tailored to control physical properties of DHPp, allowing it to be useful for different applications i.e. tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings.
US08575274B2 Multi-solution bone cements and methods of making the same
The present invention relates to bone cements and, more particularly, to multi-solution bone cements and methods for making the same. An embodiment of the present invention provides multi-solution bone cements which include cross-linked PMMA beads, thereby providing for a significant increase in the polymer-to-monomer (P:M) ratio. Another embodiment of the present invention provides cross-linked PMMA beads which are surface modified with unsaturated carbon double bonds. A further embodiment of the present invention provides multi-solution bone cements made with PMMA-PMMA spherical brush polymers.
US08575273B2 Coupling agents and compositions produced using them
Certain embodiments described herein are directed to silane coupling agents that may be used, for example, to covalently couple a polymer to a filler. In some examples, devices that include the polymer-silane coupling agent-filler compositions are also described.
US08575271B2 Monovinylaromatic polymer composition comprising a polymer made from renewable resources as a dispersed phase
The present invention concerns a monovinylaromatic polymer composition comprising a bio-sourced polymer dispersed phase and optionally a rubber dispersed phase wherein said bio-sourced polymer dispersed phase is predominantly made of particles having a size of less than 10 μm. The present invention also relates to a process (hereunder referred as the first process) to make said monovinylaromatic polymer composition, said process comprising admixing: a monovinylaromatic monomer, at least one bio-sourced polymer, optionally a rubber, at conditions effective to polymerize at least a part of the monovinylaromatic monomer and generate a compatibilizer of the bio-sourced polymer and monovinylaromatic polymer. The present invention also relates to a process (hereunder referred as the second process) to make said monovinylaromatic polymer composition, said process comprising admixing: a monovinylaromatic monomer, functionalized bio-sourced polymer-s), or mixtures of bio-sourced polymer(s) and functionalized bio-sourced polymer(s), optionally a rubber, at conditions effective to polymerize at least a part of the monovinylaromatic monomer. The present invention also relates to a process (hereunder referred as the third process) to make said monovinylaromatic polymer composition, said process comprising blending in the molten state functionalized bio-sourced polymer(s) (or mixtures of bio-sourced polymer(s) and functionalized bio-sourced polymer(s)) with monovinylaromatic polymer, said monovinylaromatic polymer comprising optionally a rubber.
US08575270B2 Copolyester composition and method for producing copolyester polymer
A copolyester composition includes: an aliphatic-aromatic copolyester; a coupling agent including a compound having an epoxy functional group; and a cocatalyst including a carboxylate of manganese and a carboxylate of zinc, wherein a weight ratio of the carboxylate of manganese to the carboxylate of zinc ranges from 1:3 to 3:1, and the cocatalyst is present in an amount ranging from 0.03-0.2 part by weight based on 100 parts by weight of the aliphatic-aromatic copolyester.
US08575266B2 Preparing silicone emulsions
The invention provides a process for preparing emulsions of organopolysiloxanes (O), which includes polymerizing: (1) 100 parts by weight of hydroxyl-terminated organopolysiloxanes and (2) at least 0.01 part by weight of trialkylsilyl-terminated organopolysiloxanes having a viscosity of at least 55 mm2/s in the presence of (3) acidic catalyst and (4) emulsifier in an aqueous medium until the desired molecular size is reached.
US08575263B2 Polycarbonate resin composition and formed product thereof
In a polycarbonate resin composition containing a polycarbonate resin and a polycarbosilane compound, the use of the polycarbosilane compound modifies the surface properties of the polycarbonate resin composition without adversely affecting the intrinsic characteristics of the polycarbonate resin, such as transparency, heat resistance, and mechanical properties, e.g., impact resistance. A polycarbonate resin composition containing 100 parts by mass of a polycarbonate resin, 0.001 to 1 part by mass of a metal salt compound, and 0.005 to 5 parts by mass of a polycarbosilane compound has significantly improved flame resistance and high transparency and causes markedly reduced outgassing and mold fouling, without losing impact resistance and heat resistance.
US08575259B2 Water-based paint compositions
The invention provides water-based paint compositions capable of forming coating film of excellent smoothness, distinctness of image, water resistance and chipping resistance, which comprise aqueous film-forming resin, curing agent and crosslinked resin particles having a core/shell type multilayer structure composed of the core part of a (co)polymer obtained by (co)polymerizing a monomer component comprising 30-100 mass % of polymerizable unsaturated monomer having C4-22 alkyl group and 0-70 mass % of other polymerizable unsaturated monomer, and the shell part having a crosslinked structure.
US08575255B2 Applications of shaped nano alumina hydrate as barrier property enhancer in polymers
A polymer composition having enhanced barrier properties includes a polymer base and alumina particulates dispersed within the polymer base. The alumina particulates have a secondary aspect ratio at least about 3:1. The polymer composition has an Oxygen Transfer Index of at least about 150.
US08575254B2 Polylactic acid-based composition and film formed thereof
A polylactic acid-based composition including a polylactic acid-based resin, a buffering agent; and/or a compound derived from the buffering agent.
US08575248B2 Polymer composition for microelectronic assembly
Embodiments in accordance with the present invention encompass polymer compositions that act as both a tack agent and a fluxing agent for the assembly of microelectronic components onto a variety of substrate materials. Such polymer compositions embodiments encompass a sacrificial polymer, a carrier solvent, a thermal acid generator and, optionally, formic acid.
US08575246B2 Flame-retardant thermoplastic resin composition and molded article
A flame-retardant thermoplastic resin composition that has a largely decreased corrosiveness to metals while maintaining a high degree of flame retardancy is provided, which is produced by adding a phosphinic acid salt and a compound having a specific structure to a thermoplastic resin, and molded articles with largely decreased corrosiveness to metals are also provided, so that useful molded articles can be provided as materials for mechanical machine parts, electric/electronic components, and automotive parts. The flame-retardant thermoplastic resin composition includes 65 to 99 wt % of (A) a thermoplastic resin, 1 to 35 wt % of (B) at least one phosphinic acid salt selected from the group of phosphinic acid salt, diphosphinic acid salt, polymer of phosphinic acid salts, and polymer of diphosphinic acid salts, and 0.001 to 0.70 wt % of (C) a compound having a specific, and molded articles produced therefrom.
US08575241B2 Aqueous solution of (meth)acrylic fluid comb-branched polymers with a solid content greater than 60%, manufacturing method and use as a plasticizing agent
The present invention pertains to an aqueous solution of comb-branched polymers, having a (meth)acrylic skeleton functionalized by side-chains with hydrophilic alcoxy- or hydroxy-polyalkylene glycol functions, said solution remaining stable and workable at dry solids content levels greater than 60% of its weight. The invention also pertains to a method for manufacturing such solutions, as well as their use as a plasticizing agent, and hydraulic binder-based compositions containing them.
US08575238B2 X-ray opaque coating
The disclosure relates to an X-ray opaque coating containing an epoxy resin including an iodinated phenol covalently bonded to a glycidyl ether. Iodinated phenol covalently bonded to a glycidyl ether may include iodinated bisphenol A, such as tetraiodobisphenol A, a glycidyl ether of mono-iodophenol, bis-iodephenol, tri-iodophenol, or combinations thereof. The coating may include an X-ray opaque inorganic filler. The disclosure also relates to an electronic component including a substrate and at last one device coupled to the substrate with an obfuscation layer disposed over the substrate for obscuring the device from an X-ray source. The obfuscation layer may include an X-ray opaque coating. The disclosure additionally relates to- a method of obscuring at least a portion of an electronic component by depositing an obfuscation layer that may include an X-ray opaque coating and a method of forming an X-ray opaque coating.
US08575229B2 Bioabsorbable blend for temporary scaffolding of the blood vessel wall
A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.
US08575218B2 Thiol-containing compounds for the removal of elements from tissues and formulations therefor
Methods and pharmaceutical formulations for ameliorating heavy metal toxicity and/or oxidative stress are disclosed, comprising administering pharmaceutically effective amounts of ligands according to the present disclosure. The ligands are of the general structure: where R1 comprises benzene, pyridine, pyridin-4-one, naphthalene, anthracene, phenanthrene or alkyl groups, R2 comprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, R3 comprises alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, X comprises hydrogen, lithium, sodium, potassium, rubidium, cesium, francium, alkyls, aryls, a carboxyl group, carboxylate esters, thiophosphate, N-acetyl cysteine, mercaptoacetic acid, mercaptopropionic acid, thiolsalicylate, organic groups or biological groups, n independently equals 1-10, m=1-6, Y comprises hydrogen, polymers, silicas or silica supported substrates, and Z comprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, a hydroxyl group, NH2, HSO3, halogens, a carbonyl group, organic groups, biological groups, polymers, silicas or silica supported substrates.
US08575215B2 Treatment of neurodegenerative and cardiovascular disorders
A method of treating a neurodegenerative or cardiovascular disorder with a compound of the following formula: in which X, Y, A1, A2, R1, and R2 are defined herein.
US08575213B2 Pyrethrinoid-type esters as pesticides
An ester compound represented by formula (1): wherein R1 represents hydrogen, fluorine, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkoxymethyl, or C1-C4 alkylthiomethyl; R3 represents hydrogen or methyl, R4 represents hydrogen or C1-C4 alkyl, and R5 represents hydrogen or C1-C4 alkyl; has an excellent pest control effect and is therefore useful as an active ingredient of a pest control agent.
US08575210B2 Use of indole derivatives as NURR-1 activators for treating parkinson's disease
The present invention relates to a compound derived from indole, especially a therapeutically useful compound, characterized in that it is selected from compounds of formula (I) in which R1 represents a halogen or a trifluoromethyl group, R2 represents a hydrogen atom or a C1-C4 alkyl group, R3 represents an isopropyl (1-methylethyl) group or a tert-butyl (1,1-dimethylethyl) group and n=3 or 4 and pharmaceutically acceptable salts of said compounds of formula (I). Application: Treatment of neurodegenerative diseases and more particularly of Parkinson's disease.
US08575204B2 Nicotinamide derivates useful as P38 inhibitors
Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
US08575203B2 Chemical compounds
The present invention encompasses compounds of general formula (1) wherein the groups R1 to R4, Qa, Qb, QH, L and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and their use as medicaments.
US08575200B2 Pyridin-2-yl derivatives as immunomodulating agents
The invention relates to pyridine derivatives of Formula (I) wherein A, R1, R2, R3, R4, R5, R6 and R7 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
US08575198B1 In-process control for the manufacture of glatiramer acetate
The present disclosure provides methods for manufacturing or producing glatiramer acetate having a Mp of 5000-9000 Da. These methods include: polymerizing N-carboxy anhydrides of L-alanine, benzyl-protected L-glutamic acid, trifluoroacetic acid (TFA)-protected L-lysine, and L-tyrosine to generate a sample comprising intermediate-1; treating the sample comprising intermediate-1 to partially depolymerize the protected copolymer and deprotect benzyl-protected L-glutamic acid, measuring the viscosity of the sample comprising intermediate-1 during the treatment, and ending the treatment when the viscosity of the sample is within an endpoint range, thereby generating a sample comprising intermediate-2; treating the sample comprising intermediate-2 to deprotect TFA-protected L-lysine, thereby generating intermediate-3; further processing the intermediate-3 to generate a sample glatiramer acetate; and purifying the glatiramer acetate to generate a composition comprising purified glatiramer acetate having a Mp of 5000-9000 Da.
US08575194B1 Treatment methods of cognitive, emotional and mental ailments and disorders
Methods for the treatment of cognitive, emotional and mental ailments using therapeutically effective amounts of compositions including leukotriene receptor antagonists, leukotriene synthesis inhibitors or leukotriene modifiers, zafirlukasts, montelukasts, other members of the family -lukasts, zileutons.
US08575193B2 N-substituted tetrahydroisoquinoline/isoindoline hydroxamic acid compounds
Compounds of a certain formula (I) wherein R1, R2, R3, X, Y, r, s, t, u and v have the meanings as defined in the specification, and the salts, solvates and hydrates thereof are novel effective HDAC 6 inhibitors.
US08575186B2 Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof
The present invention relates to epiminocycloalkyl[b]indole derivatives as serotonin sub-type 6 (5-HT6) modulators, pharmaceutical compositions including these compounds, and methods of preparation and use thereof. These compounds are useful in the treatment of central nervous system disorders including obesity, metabolic syndrome, cognition, and schizophrenia. The subject compounds have the structure of formula (I) with the substituents being described herein.
US08575185B2 Compositions, synthesis, and methods of utilizing quinazolinedione derivatives
The present invention provides quinazolinedione derivatives of Formulae Ia and Ib, which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder, depression and dementia.
US08575183B2 Heterocyclic compounds and their uses
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
US08575180B2 9-substituted 8-oxoadenine compound
The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.
US08575179B2 Dihydropyrazolopyrimidinone derivatives
The invention relates to compounds represented by the general formula (I) and the like. In the formula, Ar1 denotes an aryl or heteroaryl group which may have a substituent; R1 denotes a hydrogen atom, or denotes a C1-C6 alkyl, aryl, aralkyl or heteroaryl group which may have a substituent; R2 denotes an aralkyl group or a group represented by the formula (a); and R3 denotes a hydrogen atom or a C1-C6 alkyl group. The compounds of the invention have an excellent Wee1 kinase inhibitory effect, and therefore are useful in the field of medicine, especially in the field of treatment of various cancers.
US08575178B2 Isothiazolo-pyrimidinedione derivatives as TRPA1 modulators
The present invention is related to novel isothiazolo[3,4-d]pyrimidinedione and isothiazolo[5,4-d]pyrimidinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.
US08575175B2 Therapeutic agent for chronic renal failure
The present invention aims to provide a therapeutic agent for chronic renal failure, comprising as an effective ingredient a compound represented by General Formula (1) or a pharmaceutically acceptable salt thereof. That is, the present invention provides provision of a drug comprising as an effective ingredient a compound represented by General Formula (1) or a pharmaceutically acceptable salt thereof, which drug is useful not only for amelioration of renal function, but also for amelioration of anemia, activation of SOD and excretion of uremic substances.
US08575174B2 Deuterated 1-piperazino-3-phenyl-indanes for treatment of schizophrenia
The present invention relates to deuterated 1-piperazino-3-phenyl-indanes and salts thereof with activity at dopamine receptors D1 and D2 as well as the 5HT2 receptors in the central nervous system, to medicaments comprising such compounds as active ingredients, to the use of such compounds in the treatment of diseases in the central nervous system, and to methods of treatment comprising administration of such compounds.
US08575172B2 Pharmaceutical compositions of aripiprazole
An orally deliverable pharmaceutical composition provides controlled release of aripiprazole. The composition includes a therapeutically effective amount of aripiprazole and at least one pharmaceutically acceptable excipient. The compositions of the invention may exhibit one or more of the release profiles defined in the specification.
US08575171B2 Methods and compositions for treating thyroid-related medical conditions with reduced folates
The present invention provides methods and compositions for treating thyroid-related medical conditions. Many thyroid-related medical conditions exist that go undiagnosed and untreated. These conditions may be prevented and treated with reduced folates and vitamin B12. Administration of reduced folates and vitamin B12 will prevent or treat cerebrospinal folate deficiency, which is linked to thyroid-related medical conditions. Administration of reduced folates and vitamin B12 will also prevent or treat conditions associated with masked megaloblastic anemia and hypothyroidism, and other conditions brought upon through improper thyroid function. Additionally, it is commonplace to treat many thyroid conditions with anti-thyroid drugs or thyroid stimulating drugs. This practice alone is also responsible for causing, or not beneficially addressing, adverse conditions that can be prevented or treated through the methods and compositions discussed herein.
US08575168B2 Compounds and compositions as modulators of GPR119 activity
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
US08575166B2 Phthalazine-containing antidiabetic compounds
This invention provides for certain phthalazine-containing compounds of the formula (I) or a pharmaceutically acceptable salt, ester or solvate thereof, wherein G is an optionally substituted N—N containing heteroaryl group and the variables are defined herein; the inventive compounds are agonists of the G-protein coupled receptor 40 (GPR40, also known as free fatty acid receptor FFAR). This invention further relates to pharmaceutical compositions containing these compounds, and the use of these compounds to regulate insulin levels in a mammal. The compounds may be used, for example in the prevention and treatment of Type 2 diabetes mellitus and in the prevention and treatment of conditions related to Type 2 diabetes mellitus, such as insulin resistance, obesity and lipid disorders.
US08575164B2 Combination cancer therapy
Methods and compositions for treating tumors or tumor metastases in a patient, comprising administering to the patient simultaneously or sequentially (a) a therapeutically effective amount of an anti-cancer agent and (b) an IGF1R inhibitor compound of Formula I, with or without additional agents or treatments, such as other anti-cancer drugs or radiation therapy. Suitable IGF1R inhibitor may be represented by Formula I: wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein.
US08575163B2 Pyrrolopyridinylpyrimidin-2-ylamine derivatives
Pyrrolopyridinylpyrimidin-2-ylamine derivatives of the formula (I), in which R1-R6 and R1 have the meanings indicated in claim 1, are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumours.
US08575158B2 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
The present invention relates to 1-phenyl-substituted heterocyclyl derivatives of the formula (I), wherein X, Y, Z, n, R1, R2, R3, R4, R5, R6, R7 and R10 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
US08575157B2 Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, lo1, lo2, lo5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
US08575150B2 Triazole derivatives for treatment of Alzheimer's disease
According to the invention there is provided a compound of formula I or a pharmaceutically acceptable salt or hydrate thereof; wherein the variables are as defined herein. The compounds selectively attenuate the production of Aβ42 and hence are useful in treatment of Alzheimer's disease and related conditions.
US08575149B2 5HT2C receptor modulators
The present invention relates to novel compounds of Formula (I): which act as 5HT2C receptor modulators. These compounds are useful in pharmaceutical compositions whose use includes the treatment of obesity.
US08575146B2 Pharmaceutical uses of staurosporine derivatives
This application relates to the use of staurosporines derivatives for the curative, palliative or prophylactic treatment of allergic rhinitis, allergic dermatitis, drug allergy or food allergy, angioedema, urticaria, sudden infant death syndrome, bronchopulmonary aspergillosis, multiple sclerosis, or mastocytosis; and to a method of treatment of warm-blooded animals in which a therapeutically effective dose of a compound of a Staurosporine Derivative is administered to a warm-blooded animal suffering from one of the diseases or conditions mentioned above.
US08575138B2 Method for providing neuroprotection
A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an ═N—OH group, R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond, B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond, C is a hydrogen atom or together with D a carbon-carbon bond, D is a hydrogen atom or together with C a carbon-carbon bond, E is a hydrogen atom or together with F a carbon-carbon bond, F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.
US08575136B2 2-methylene-1α-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof
Compounds of formula I are provided where X1 and X2 are independently selected from H or hydroxy protecting groups. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
US08575135B2 Antiviral compounds
The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
US08575133B2 Cosmetic compositions
The present invention relates to pigmented emulsion cosmetic compositions containing emulsifying silicone elastomers that provide a natural appearance to the skin upon application. In particular, these cosmetic compositions are formulated such that agglomeration of the pigment upon application to the skin is minimized.
US08575131B2 Glucuronic acid-containing glucan, process for production of same, and use of same
An object of the present invention is to provide a uronic acid-containing glucan or a modified product thereof. The glucuronic acid-containing glucan of the present invention is a glucuronic acid-containing glucan in which a glucuronic acid residue is bound to at least one non-reducing end of a glucan, and the glucan is a branched α-1,4 glucan or a linear α-1,4 glucan. The glucuronic acid-containing glucan of the present invention can be provided by allowing α-glucan phosphorylase derived from Aquifex aeolicus VF5 to act on glucuronic acid-1-phosphate to thereby transfer a glucuronic acid residue to the non-reducing end of the receptor glucan.
US08575129B2 Amides of hyaluronic acid and the derivatives thereof and a process for their preparation
An amide of hyaluronic acid or a derivative thereof which comprises at least one repetitive unit of general formula (I): wherein R=NR6R7, or alcoholic group of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, OH, O—, alcoholic group of hyaluronic acid, amino group of deacylated hyaluronic acid; R1, R2, R3, R4=H, SO3—, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, —CO—(CH2)2—COOY; Y=negative charge, or H; R5=—CO—CH3, H, SO3—, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, acylic group of hyaluronic acid; R6=is H or a aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; R7=is H or an aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; wherein at least one of R or R5 forms an amide group.
US08575127B2 Antithrombotic diadenosine tetraphosphates and related analogs
The invention features compounds of formula I and methods of their use as antiplatelet and antithrombotic compounds: H/N=Qχ2OOOOΛQ2-N, HR6/NIf)(^XMO-MγτOM°τX1MQ′)r(^rfHOOHHOOQHiNχiR2 Formula (I).
US08575126B2 Conjugate constructs, delivery, and use for treatment of disease
Pharmaceutical formulations of antisense peptide-conjugated phosphorodiamidate morpholino olgomers and methods of use for treatment of apicomplexan infections are disclosed. The invention is particularly directed to treatment of Toxoplasma gondii infections.
US08575125B2 Selective inhibitors of CB2 receptor expression and/or activity for the treatment of obesity and obesity-related disorders
The invention relates to a method for treating and/or preventing obesity and/or obesity-related disorders by administering to a subject in need thereof a selective inhibitor of cannabinoid type 2 (CB2) receptor expression.
US08575123B2 Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components.
US08575120B2 Genetic alterations on chromosome 12 and methods of use thereof for the diagnosis and treatment of type 1 diabetes
Compositions and methods for the detection and treatment of T1D are provided.
US08575118B2 Antiviral compounds
The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
US08575117B2 Proliferation inhibitor of helicobacter pylori including alpha-n-acetyl-glucosaminyl bond-containing monosaccharide derivatives
A method for inhibiting proliferation of Helicobacter pylori including a compound that can simply be mass-produced, can specifically inhibit the proliferation of H. pylori, which has high safety and never generates any resistant bacteria, as well as a diet of a food or beverage, and a pharmaceutical preparation containing the proliferation inhibitor of Helicobacter pylori. The proliferation inhibitor of Helicobacter pylori comprises an alpha-N-acetyl-glucosaminyl bond-containing monosaccharide derivative represented by the following chemical formula (1) GlcNAc1-alpha-O—Y   (1) (in the formula (1), Y is a straight-, branched- or cyclic-aliphatic hydrocarbon group having 1 to 27 carbon atoms or a straight-, branched- or cyclic-acyl group having 1 to 27 carbon atoms). The diet of the food, the beverage or the pharmaceutical preparation comprises the proliferation inhibitor of Helicobacter pylori.
US08575116B1 Polyacetylenic compounds for protecting against pancreatic islet atrophy
Pharmaceutical compositions and methods for protecting against atrophy of pancreatic islets in a human with metabolic syndromes are disclosed. The method comprises administering to the mammal a pharmaceutical composition comprising a compound having a chemical structure of formula (I) in an effective amount and a pharmaceutically acceptable carrier: wherein R is H or COCH2COOH; m=3 or 4; n=0 or 1; o=2; and p=1 or 2.
US08575112B2 Small peptide modulators of potassium channel trafficking
Provided herein are peptide modulators of ion channels. Specifically, the peptide modulators comprise the amino acid sequence VEDEC wherein V is valine, E is glutamate, D is aspartate, C is cysteine. In certain embodiments, the modulator is attached to the C-terminal end of Slo1 protein isoform. The present invention also claims conjugations of the first valine that make the peptide modulator more membrane permeable, such as myristoyl moieties and arginine-rich cell penetrating peptides. The present invention contemplates use of the peptide modulators in the treatment of diseases/malfunctions such as epilepsy, chronic pain, migraine, asthma, chronic obstructive pulmonary disease, urinary incontinence, hypertension, erectile dysfunction, irritable bowel syndrome, renal disorders of electrolyte imbalance, and possibly in certain kinds of cancer.
US08575111B2 Pharmaceutical compositions and methods for treating erectile dysfunction
The present invention relates to the use of Ang-(1-7) and/or Ang-(1-7) receptor agonist and/or Ang (1-7) analogue in treating/restoring erectile dysfunction.
US08575110B2 Peptidic nanoparticles as drug delivery and antigen display systems
Described is a new type of nanoparticle using the concept of self-organization of a single continuous chain to form peptidic nanoparticles. In particular, nanoparticles of the invention consist of aggregates of a continuous chain comprising two peptidic oligomerization domains connected by a linker segment. Preferred are coiled-coil oligomerization domains with a contiguous pattern of hydrophobic residues spaced 3 and 4 residues apart. The invention provides a drug targeting and delivery system comprising a functionalized peptidic nanoparticle comprising ligands capable of binding a receptor and drugs, and a method of treating or diagnosing humans using such functionalized peptidic nanoparticles. The invention further provides an antigen display system to be used as efficient vaccines comprising a functionalized peptidic nanoparticle comprising an antigen, and a method of vaccinating humans or non-human animals using such functionalized peptidic nanoparticles. The invention also provides processes for making peptidic nanoparticles and functionalized peptidic nanoparticles, and monomeric building blocks suitable for forming such nanoparticles.
US08575108B2 Cyclosporin compositions
A composition comprising from about 0.001% to about 0.4% cyclosporin A, a surfactant, and an oil having a specific gravity from 0.8 to 0.95 is disclosed herein.
US08575097B2 Exendin variant and conjugate thereof
The invention provides a novel Exendin variant and the Exendin variant conjugate conjugating polymer thereon, the pharmaceutical composition comprising them and use of them for treating diseases such as reducing blood glucose, treating diabetes, especially Type II diabetes. The invention also provides the use of Exendin conjugate for lowering body weight.
US08575096B2 Rapid acting insulin analogues
The invention is related to fast acting insulin analogues which can form soluble mix-tures (pre-mixed or self-mixed) with long acting insulin analogues. The fast action is achieved through monomerizing substitutions/deletions in the C-terminus of the B-chain of human insulin and the mixability with long acting insulin analogues is achieved through a substitution of the Zn-binding His in position B10 of human insulin with a Gln amino acid residue. In one embodiment the invention is related to fast acting insulin analogues in which at least one of the natural amino acid residues in position B22-B30 in the human B-chain has been substituted with another amino acid residue having the effect of promoting formation of the monomeric form of insulin, the His amino acid residue in position 10 in the B-chain is substituted with a Gln and wherein further one or more of the amino acid residues in position B22-B30 optionally have been deleted.
US08575094B2 Use of type-B lantibiotic-based compounds having antimicrobial activity
A method for the treatment or prophylaxis of a microbial infection of the lower intestine or colon in a subject is described, wherein the method comprises administration to the subject of a type-B lantibiotic, wherein the type-B lantibiotic may include compounds selected from the group consisting of mersacidin, actagardine, plantaricin, planosporicin, ruminococcin, antibiotic 10789, michiganin and haloduracin, and derivatives and variants thereof.
US08575093B2 Composition and method for treating Streptococcus pneumoniae infection
A method of preventing and/or treating S. pneumoniae infection in mammalian subjects, wherein said method comprises administering to said subjects a composition comprising one or more agents that are capable of inhibiting the binding of the S. pneumoniae cell wall protein FBA to the respiratory tract cells of said subject.
US08575091B1 Amylin analogues and pharmaceutical compositions thereof
The invention relates to polypeptides comprising an amino acid sequence which is an analogue of human amylin, pharmaceutical compositions comprising these polypeptides, and these polypeptides for use as medicaments.
US08575090B2 Amylin analogues and pharmaceutical compositions thereof
The invention relates to polypeptides comprising an amino acid sequence which is an analogue of pramlintide, pharmaceutical compositions comprising these polypeptides, and these polypeptides for use as medicaments.
US08575088B2 Method of preventing acute or sub-acute hepatic failure by administering a long-acting recombinant human soluble tumor necrosis factor alpha receptor II fusion protein
The present invention belongs to the field of the application of genetic engineering and gene function, and it is directed to a new medical use of the gene encoding the recombinant soluble tumor necrosis factor α receptor (HusTNFR). The present invention made intervention to fulminant hepatic failure in mice by use of the long-acting recombinant human soluble tumor necrosis factor αreceptor and the classic animal models of acute and sub-acute hepatic failure. The results showed that the long-acting soluble tumor necrosis factor αreceptor of the present invention has a half-life extended more than 10 times, and it significantly decreased the mortality of model animals and has superior therapeutic effect for the treatment and/or prophylaxis of acute and sub-acute hepatic failure in model animals. These receptors have a noticeable therapeutic effect for the treatment and/or prophylaxis of acute and sub-acute hepatic failure in comparison with the non-long-acting HusTNFR.
US08575087B2 Treatment of cancers with A-8R peptide
The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
US08575081B2 Synthesis of diester-based biolubricants from epoxides
The present invention is generally directed to methods of making diester-based lubricant compositions, wherein formation of diester species proceeds via direct esterification of epoxide intermediates. In some embodiments, the methods for making such diester-based lubricants utilize a biomass precursor and/or low value (e.g., Fischer-Tropsch (FT) olefins and/or alcohols) so as to produce high value diester-based lubricants. In some embodiments, such diester-based lubricants are derived from FT olefins and fatty acids. The fatty acids can be from a bio-based source (i.e., biomass, renewable source) or can be derived from FT alcohols via oxidation.
US08575078B2 Coating for elastomeric linear profiles, in particular windscreen-wiper blades, and process for production thereof
The present invention relates to a coating for elastomeric linear profiles, where the coating comprises solid lubricant embedded into a polymeric matrix. It also relates to a wiper blade for windscreen wipers, comprising this type of coating, and also to a process for the production of an elastomeric linear profile coated according to the invention. The polymeric matrix with embedded solid lubricant is obtained by polymerizing, in the absence of polymeric binders, a mixture comprising the solid lubricant and low-molecular-weight crosslinking agent. In one embodiment, the matrix is obtained from the thermal polymerization of the low-molecular-weight crosslinking agent hexamethoxymethylmelamine. Examples of solid lubricants are graphite and HDPE.
US08575074B2 Insensitive explosive composition and method of fracturing rock using an extrudable form of the composition
Insensitive explosive compositions were prepared by reacting di-isocyanate and/or poly-isocyanate monomers with an explosive diamine monomer. Prior to a final cure, the compositions are extrudable. The di-isocyanate monomers tend to produce tough, rubbery materials while polyfunctional monomers (i.e. having more than two isocyanate groups) tend to form rigid products. The extrudable form of the composition may be used in a variety of applications including rock fracturing.
US08575073B2 Slickwater treatment fluid and method
A treatment fluid for treating a subterranean formation penetrated by a wellbore is formed from water, a polyacrylamide in an amount of less than about 0.5% by weight of the fluid for reducing friction of the fluid and a stabilized peroxide breaker. A method of treating a subterranean formation penetrated by a wellbore is carried out by forming treatment fluid comprising water, a polyacrylamide in an amount of less than about 0.5% by weight of the fluid for reducing friction of the fluid and a stabilized peroxide breaker. The treatment fluid is introduced into the formation through the wellbore at a pressure above the fracture pressure of the formation.
US08575070B2 Methods of constructing and screening libraries of peptide structures
The present invention provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming their native conformations independently of artificial scaffolds or flanking sequences in the proteins from which they are derived. The libraries can be highly diverse such that they are representative of the repertoire of protein structures existing in nature. The libraries can also be non-redundant or normalized such that the bias towards specific structures existing in source data sets and/or in nature is/are removed. In a particularly preferred embodiment, the present invention provides 30,000 independent fold structures produced by this method. The present invention also provides computer-readable media and systems comprising structural data in relation to the peptide libraries, and methods for displaying and screening the libraries.
US08575068B2 Pyrazinothiazines having herbicidal action
Substituted pyridazines of the formula I in which the variables are defined according to the description, processes and intermediates for preparing the compounds of the formula I and their N oxides, their agriculturally useful salts, compositions comprising them and their use as herbicides, and also a method for controlling unwanted vegetation.
US08575065B2 Acrylate/methacrylate-based star copolymer/anthranilic diamide compositions for propagle coating
Disclosed is an insecticidal composition comprising by weight based on the total weight of the composition: (a) from about 9 to about 91% of one or more anthranilic diamide insecticides; and (b) from about 9 to about 91% of an acrylate/methacrylate-based star copolymer component having a water solubility of at least about 5% by weight at 20° C., a hydrophilic-lipophilic balance value of at least about 3, and an average molecular weight ranging from about 1,500 to about 150,000 daltons; wherein the ratio of component (b) to component (a) is about 1:10 to about 10:1 by weight. Also disclosed is a geotropic propagule coated with the insecticidal composition. Further disclosed is a liquid composition comprising the insecticidal composition, and a method for protecting a geotropic propagule and plant derived therefrom from a phytophagous insect pest.
US08575064B2 Synergistic fungicidal active substance combinations
The novel active compound combinations of a carboxamide of the general formula (I) (group 1) in which R, G, R1 and A have the meanings given in the description and the active compound groups (2) to (23) listed in the description have very good fungicidal properties.
US08575059B1 Method and system for forming plug and play metal compound catalysts
A metal compound catalyst is formed by vaporizing a quantity of catalyst material and a quantity of carrier thereby forming a vapor cloud, exposing the vapor cloud to a co-reactant and quenching the vapor cloud. The nanoparticles are impregnated onto supports. The supports are able to be used in existing heterogeneous catalysis systems. A system for forming metal compound catalysts comprises components for vaporizing a quantity of catalyst material and a quantity of carrier, quenching the resulting vapor cloud, forming precipitate nanoparticles comprising a portion of catalyst material and a portion of carrier, and subjecting the nanoparticles to a co-reactant. The system further comprises components for impregnating the supports with the nanoparticles.
US08575056B2 Method of preparing a catalytic composition for dimerization, co-dimerization and oligomerization of olefins
The present invention describes a method of preparing a catalytic composition used for oligomerization, co-dimerization or polymerization of olefins, wherein the compound obtained upon contacting at least one iron compound with at least one nitrogen-containing compound is subjected to an oxidation stage prior to being mixed with an activating agent and optionally with a solvent.The present invention also describes the catalytic composition obtained by means of said preparation method and the use thereof for oligomerization, co-dimerization or polymerization of olefins.
US08575055B2 Surface-modified zeolites and methods for preparing the same
Surface-modified zeolites and methods for preparing surface-modified zeolites are provided. A hybrid polymer formed from a silicon alkoxide and a metal alkoxide, a co-monomer, or both, is contacted with a zeolite suspension. The zeolite suspension comprises a sodium-, an ammonium-, or a hydrogen-form zeolite and a solvent. The hybrid polymer and zeolite suspension are contacted under conditions sufficient to deposit hybrid polymer on external surfaces of the zeolite to form a treated zeolite. Solvent is removed therefrom. The treated zeolite is dried and calcinated to form a dried and calcinated treated zeolite. Forming of the zeolite suspension and the contacting, removing, drying, and calcinating steps are provided in one selectivation sequence to produce a surface-modified zeolite from the ammonium-form zeolite and the hydrogen-form zeolite. If the dried and calcinated treated zeolite is a sodium-form zeolite, the sodium is exchanged with ammonium and then additionally dried and calcinated.
US08575047B2 Optical glass, preform for precision press molding, and optical element
The present invention relates to an optical glass with a high refractive index and good precision press moldability, and a preform for precision press molding and an optical element that are comprised of the optical glass. The present invention further relates to a method of manufacturing an optical element, a lens unit being equipped with an optical element and an image pickup device being equipped with a lens unit.
US08575046B2 SMC sheet and method for manufacturing the same
A SMC sheet includes: a sheet material body made of a resin compound containing uncured thermosetting resin; and a fiber sheet embedded as an intermediate layer in the sheet material body and impregnated with the thermosetting resin of the sheet material body. Short fiber is distributed on at least one side of the fiber sheet in the sheet material body.
US08575037B2 Method for fabricating a cavity structure, for fabricating a cavity structure for a semiconductor structure and a semiconductor microphone fabricated by the same
Embodiments show a method for fabricating a cavity structure, a semiconductor structure, a cavity structure for a semiconductor device and a semiconductor microphone fabricated by the same. In some embodiments the method for fabricating a cavity structure comprises providing a first layer, depositing a carbon layer on the first layer, covering at least partially the carbon layer with a second layer to define the cavity structure, removing by means of dry etching the carbon layer between the first and second layer so that the cavity structure is formed.
US08575033B2 Carbosilane precursors for low temperature film deposition
Provided are processes for the low temperature deposition of silicon-containing films using carbosilane precursors containing a carbon atom bridging at least two silicon atoms. Certain methods comprise providing a substrate; in a PECVD process, exposing the substrate surface to a carbosilane precursor containing at least one carbon atom bridging at least two silicon atoms; exposing the carbosilane precursor to a low-powered energy sourcedirect plasma to provide a carbosilane at the substrate surface; and densifying the carbosilanestripping away at least some of the hydrogen atoms to provide a film comprising SiC. The SiC film may be exposed to the carbosilane surface to a nitrogen source to provide a film comprising SiCN.
US08575031B2 Method of forming a fine pattern, display substrate, and method of manufacturing the same using the method of forming a fine pattern
A method is provided for forming a fine pattern. In the method, a first fine pattern and a first metal pattern are formed by respectively patterning a first fine pattern layer on a base substrate and a first metal layer on the first fine pattern layer. A second fine pattern layer and a second metal layer are sequentially formed over the first fine pattern and the first metal pattern. The second metal layer is patterned, so that a second metal pattern between adjacent portions of the first fine pattern. The second fine pattern layer is patterned using the second metal pattern as a mask, so that a second fine pattern is formed between adjacent portions of the first fine pattern.
US08575029B2 Technique for forming metal lines in a semiconductor by adapting the temperature dependence of the line resistance
By moderately introducing defects into a highly conductive material, such as copper, the resistance versus temperature behavior may be significantly modified so that enhanced electromigration behavior and/or electrical performance may be obtained in metallization structures of advanced semiconductor devices. The defect-related portion of the resistance may be moderately increased so as to change the slope of the resistance versus temperature curve, thereby allowing the incorporation of impurity atoms for enhancing the electromigration endurance while not unduly increasing the overall resistance at the operating temperature or even reducing the corresponding resistance at the specified operating temperature. Thus, by appropriately designing the electrical resistance for a target operating temperature, both the electromigration behavior and the electrical performance may be enhanced.
US08575027B1 Sputtering and aligning multiple layers having different boundaries
Provided are methods and systems for forming discreet multilayered structures. Each structure may be deposited by in situ deposition of multiple layers at one of multiple site isolation regions provided on the same substrate for use in combinatorial processing. Alignment of different layers within each structure is provided by using two or more differently sized openings in-between one or more sputtering targets and substrate. Specifically, deposition of a first layer is performed through the first opening that defines a first deposition area. A shutter having a second smaller opening is then positioned in-between the one or more targets and substrate. Sputtering of a second layer is then performed through this second opening that defines a second deposition area. This second deposition area may be located within the first deposition area based on sizing and alignment of the openings as well as alignment of the substrate.
US08575025B2 Templated circuitry fabrication
A method of making templated circuitry employs a template system that includes a template of an insulator material on a carrier having a conductive surface. The template includes multiple levels and multiple regions, wherein a first level exposes the conductive surface of the carrier. A first metal is electrochemically deposited on the conductive surface in first regions of the first level. A circuit material is deposited to cover the first metal. The template is etched until a second level of the template exposes the conductive surface in second regions on opposite sides of the first regions. A second metal is electrochemically deposited on the conductive surface in the second regions. The template of deposited materials is transferred from the carrier to a substrate.
US08575023B2 Contact formation method, semiconductor device manufacturing method, and semiconductor device
A semiconductor device manufacturing method which achieves a contact of a low resistivity is provided.In a state where a first metal layer in contact with a semiconductor is covered with a second metal layer for preventing oxidation, only the first metal layer is silicided to form a silicide layer with no oxygen mixed therein. As a material of the first metal layer, a metal having a work function difference of a predetermined value from the semiconductor is used. As a material of the second metal layer, a metal which does not react with the first metal layer at an annealing temperature is used.
US08575021B2 Substrate processing including a masking layer
Methods for substrate processing are described. The methods include forming a material layer on a substrate. The methods include selecting constituents of a molecular masking layer (MML) to remove an effect of variations in the material layer as a result of substrate processing. The methods include normalizing the surface characteristics of the material layer by selectively depositing the MML on the material layer.
US08575018B2 Semiconductor device and method of forming bump structure with multi-layer UBM around bump formation area
A semiconductor wafer has a first conductive layer formed over its active surface. A first insulating layer is formed over the substrate and first conductive layer. A second conductive layer is formed over the first conductive layer and first insulating layer. A UBM layer is formed around a bump formation area over the second conductive layer. The UBM layer can be two stacked metal layers or three stacked metal layers. The second conductive layer is exposed in the bump formation area. A second insulating layer is formed over the UBM layer and second conductive layer. A portion of the second insulating layer is removed over the bump formation area and a portion of the UBM layer. A bump is formed over the second conductive layer in the bump formation area. The bump contacts the UBM layer to seal a contact interface between the bump and second conductive layer.
US08575016B1 Method for etching gate stack
A method for etching a metal gate stack is provided. The method includes forming a gate stack on a substrate, where the gate stack includes a metal gate. A wet etch process is performed on the gate stack. The wet etch process includes submersing the substrate with the gate stack in an aqueous solution composed of a wet etchant and an oxidizer, removing the substrate from the solution and rinsing the solution from the etched gate stack.
US08575015B2 Lateral trench mosfet having a field plate
One embodiment relates to an integrated circuit that includes a lateral trench MOSFET disposed in a semiconductor body. The lateral trench MOSFET includes source and drain regions having a body region therebetween. A gate electrode region is disposed in a trench that extends beneath the surface of the semiconductor body at least partially between the source and drain. A gate dielectric separates the gate electrode region from the semiconductor body. In addition, a field plate region in the trench is coupled to the gate electrode region, and a field plate dielectric separates the field plate region from the semiconductor body. Other integrated circuits and methods are also disclosed.
US08575010B2 Method for fabricating a semiconductor substrate
The invention relates to a method for fabricating a semiconductor substrate by providing a silicon on insulator type substrate that includes a base, an insulating layer and a first semiconductor layer, doping the first semiconductor layer to thereby obtain a modified first semiconductor layer, and providing a second semiconductor layer with a different dopant concentration than the modified first semiconductor layer over or on the modified first semiconductor layer. With this method, an improved dopant concentration profile can be achieved through the various layers which makes the substrates in particular more suitable for various optoelectronic applications.
US08575008B2 Post-fabrication self-aligned initialization of integrated devices
Creating a localized region of material having a target chemical composition by defining an electrical circuit on a substrate, and depositing on the electrical circuit one or more layers of materials having one or more chemical compositions. An electrical current pulse is applied to the electrical circuit to create a self-aligned localized region having the target chemical composition. Applying the electrical current pulse causes a portion of the one or more layers of materials to be heated, resulting in the target chemical composition.
US08575007B2 Selective electromigration improvement for high current C4s
The invention includes embodiments of a method for designing a flip chip and the resulting structure. The starting point is a flip chip with a semiconductor substrate, one or more wiring levels, and a plurality of I/O contact pads (last metal pads/bond pads) for receiving and sending electrical current. There is also a plurality of C4 bumps for connecting the I/O contact pads to another substrate. Then it is determined which of the C4s of the plurality of C4 bumps have a level of susceptibility to electromigration damage that meets or exceeds a threshold level of susceptibility, and in response, plating a conductive structure with a high electrical current carrying capacity (such as a copper pillar, copper pedestal, or partial copper pedestal) onto the corresponding I/O contact pads and adding a solder ball to a top portion of the conductive structure. The resulting structure is a flip chip wherein only a select few C4 bumps use enhanced C4s (such as copper pedestals) reducing the chance of defects.
US08575003B2 Method for producing a semiconductor component
Presented is a method for producing an optoelectronic component. The method includes separating a semiconductor layer based on a III-V-compound semiconductor material from a substrate by irradiation with a laser beam having a plateau-like spatial beam profile, where individual regions of the semiconductor layer are irradiated successively.
US08575001B2 Methods for directly bonding together semiconductor structures, and bonded semiconductor structures formed using such methods
Embodiments of the present invention include methods of directly bonding together semiconductor structures. In some embodiments, a cap layer may be provided at an interface between directly bonded metal features of the semiconductor structures. In some embodiments, impurities are provided within the directly bonded metal features of the semiconductor structures. Bonded semiconductor structures are formed using such methods.
US08574999B2 Blocking layers for leakage current reduction in DRAM devices
A method for forming a DRAM MIM capacitor stack having low leakage current involves the use of a first electrode that serves as a template for promoting the high k phase of a subsequently deposited dielectric layer. The high k dielectric layer comprises a doped material that can be crystallized after a subsequent annealing treatment. An amorphous blocking is formed on the dielectric layer. The thickness of the blocking layer is chosen such that the blocking layer remains amorphous after a subsequent annealing treatment. A second electrode layer compatible with the blocking layer is formed on the blocking layer.
US08574998B2 Leakage reduction in DRAM MIM capacitors
A method for reducing the leakage current in DRAM MIM capacitors comprises forming a multi-layer dielectric stack from an amorphous highly doped material, an amorphous high band gap material, and a lightly or non-doped material. The highly doped material will remain amorphous (<30% crystalline) after an anneal step. The high band gap material will remain amorphous (<30% crystalline) after an anneal step. The lightly or non-doped material will become crystalline (≧30% crystalline) after an anneal step. The high band gap material is formed between the amorphous highly doped material and the lightly or non-doped material and provides an intermediate barrier to conduction through the multi-layer dielectric stack.
US08574995B2 Source/drain doping method in 3D devices
The present disclosure provides methods of semiconductor device fabrication for 3D devices. One method includes provide a substrate having a recess and forming a doping layer on the substrate and in the recess. The substrate is then annealed. The annealing drives dopants of a first type from the doping layer into the substrate. This can form a doped region that may be the source/drain extension of the 3D device. An epitaxial region is then grown in the recess. The epitaxial region can form the source/drain region of the 3D device.
US08574984B2 Manufacturing method of semiconductor integrated circuit device
A method of manufacturing a semiconductor integrated circuit device includes defining a first area by forming a separating area on a substrate, and forming a tunnel film in the first area, a floating gate on the tunnel film, a first electrode in the separating area, a first film on the floating gate, a second film on the first electrode, a control gate on the first film, a second electrode on the second film, and source and drain areas in the first area. The method includes forming a first interlayer film to cover the control gate and the second electrode, forming, in the first interlayer film, a conductive via plug reaching the second electrode, and forming, on the first interlayer film, a second wiring electrically coupled to the second electrode via the conductive via plug, and a first wiring that is capacitively-coupled to the second wiring and to the second electrode.
US08574983B2 Method for fabricating a DRAM capacitor having increased thermal and chemical stability
A method for fabricating a dynamic random access memory (DRAM) capacitor includes forming a first electrode film. The first electrode film comprises a conductive binary metal compound and a dopant. The dopant may have a uniform or non-uniform concentration within the first electrode film. A high-k dielectric film is formed over the first electrode film. A second electrode film is formed over the dielectric film. The second electrode film comprises a conductive binary metal compound and a dopant. The dopant may have a uniform or non-uniform concentration within the second electrode film. The dopants and their distribution are chosen so that the crystal structure of the surface of the electrode is not degraded if the electrode is to be used as a templating structure for subsequent layer formation. Additionally, the dopants and their distribution are chosen so that the work function of the electrodes is not degraded.
US08574979B2 Method for integrating silicon germanium and carbon doped silicon with source/drain regions in a strained CMOS process flow
The disclosure provides a semiconductor device and method of manufacture therefore. The method for manufacturing the semiconductor device, in one embodiment, includes providing a substrate (210) having a PMOS device region (220) and NMOS device region (260). Thereafter, a first gate structure (240) and a second gate structure (280) are formed over the PMOS device region and the NMOS device region, respectively. Additionally, recessed epitaxial SiGe regions (710) may be formed in the substrate on opposing sides of the first gate structure. Moreover, first source/drain regions may be formed on opposing sides of the first gate structure and second source/drain regions on opposing sides of the second gate structure. The first source/drain regions and second source/drain regions may then be annealed to form activated first source/drain regions (1110) and activated second source/drain regions (1120), respectively. Additionally, recessed epitaxial carbon doped silicon regions (1410) may be formed in the substrate on opposing sides of the second gate structure after annealing.
US08574978B1 Method for forming semiconductor device
A method for forming a semiconductor device includes firstly providing a gate structure disposed on a substrate and a first nitride material layer disposed on the gate structure, secondly performing a protective step to modify the first nitride material layer in the presence of oxygen, then forming a second nitride material layer on the substrate, and later performing a removal step to remove the second nitride material layer without substantially slashing the modified first nitride material layer.
US08574977B2 Method for manufacturing stack structure of PMOS device and adjusting gate work function
The present disclosure provides a method for manufacturing a gate stack structure and adjusting a gate work function for a PMOS device, comprising: growing an ultra-thin interface oxide layer or oxynitride layer on a semiconductor substrate by rapid thermal oxidation or chemical method after conventional LOCOS or STI dielectric isolation is completed; depositing high-K gate dielectric and performing rapid thermal annealing; depositing a composite metal gate; depositing a barrier metal layer; depositing a polysilicon film and a hard mask and then performing photolithography and etching the hard mask; removing photoresist and etching the polysilicon film, the barrier metal layer, the metal gate, the high-K gate dielectric, and the interface oxide layer in sequence to form a gate stack structure of polysilicon film/barrier metal layer/metal gate/high-K gate dielectric; forming spacers, source/drain implantation in a conventional manner and performing rapid thermal annealing, whereby while source/drain dopants are activated, adjusting of metal gate effective work function of the PMOS device is achieved.
US08574976B2 Semiconductor device and manufacturing method thereof
A TFT having a high threshold voltage is connected to the source electrode of each TFT that constitutes a CMOS circuit. In another aspect, pixel thin-film transistors are constructed such that a thin-film transistor more distant from a gate line drive circuit has a lower threshold voltage. In a further aspect, a control film that is removable in a later step is formed on the surface of the channel forming region of a TFT, and doping is performed from above the control film.
US08574970B2 Method of forming an extremely thin semiconductor insulator (ETSOI) FET having a stair-shaped raised source/drain
A MOSFET device is formed on top of a semiconductor-on-insulator (SOI) substrate having a semiconductor layer with a thickness ranging from 3 nm to 20 nm. A stair-shape raised extension, a raised source region and a raised drain region (S/D) are formed on top of the SOI substrate. The thinner raised extension region abuts at a thin gate sidewall spacer, lowering the extension resistance without significantly increasing the parasitic resistance. A single epitaxial growth forms the thinner raised extension and the thicker raised S/D preferably simultaneously, reducing the fabrication cost as well as the contact resistance between the raised S/D and the extension. A method of forming the aforementioned MOSFET device is also provided.
US08574959B2 Semiconductor device and method of forming bump-on-lead interconnection
A semiconductor device has a semiconductor die with a plurality of composite bumps formed over a surface of the semiconductor die. The composite bumps have a fusible portion and non-fusible portion, such as a conductive pillar and bump formed over the conductive pillar. The composite bumps can also be tapered. Conductive traces are formed over a substrate with interconnect sites having edges parallel to the conductive trace from a plan view for increasing escape routing density. The interconnect site can have a width less than 1.2 times a width of the conductive trace. The composite bumps are wider than the interconnect sites. The fusible portion of the composite bumps is bonded to the interconnect sites so that the fusible portion covers a top surface and side surface of the interconnect sites. An encapsulant is deposited around the composite bumps between the semiconductor die and substrate.
US08574958B2 Method for manufacturing a gate-control diode semiconductor memory device
This invention belongs to semiconductor device manufacturing field and discloses a method for manufacturing a gate-control diode semiconductor storage device. When the floating gate voltage is relatively high, the channel under the floating gate is of n type and a simple gate-control pn junction structure is configured; by controlling effective n-type concentration of the ZnO film through back-gate control, inverting the n-type ZnO into p-type through a floating gate and using NiO as a p-type semiconductor, an n-p-n-p doping structure is formed while the quantity of charges in the floating gate determines the device threshold voltage, thus realizing memory functions. This invention features capacity of manufacturing gate-control diode memory devices able to reduce the chip power consumption through advantages of high driving current and small sub-threshold swing. This invention is applicable to semiconductor devices manufacturing based on flexible substrate and flat panel displays and floating gate memories, etc.
US08574955B2 Method for producing light-emitting film and light-emitting device
Provided is a light-emitting film having controllable resistivity, and a high-luminance light-emitting device, which can be driven at a low voltage, using such light-emitting film. The light-emitting film includes Cu as an addition element in a zinc sulfide compound which is a base material, wherein the zinc sulfide compound includes columnar ZnS crystals, and sites formed of copper sulfide on a grain boundary where the ZnS crystals are in contact with each other.
US08574953B2 Low temperature melt-processing of organic-inorganic hybrid
The present invention provides a process for preparing a melt-processed organic-inorganic hybrid material including the steps of maintaining a solid organic-inorganic hybrid material at a temperature above the melting point but below the decomposition temperature of the organic-inorganic hybrid material for a period of time sufficient to form a uniform melt and thereafter, cooling the uniform melt to an ambient temperature under conditions sufficient to produce the melt-processed organic-inorganic hybrid material.
US08574943B2 Method for manufacturing solar cells
Methods and materials used to manufacture a series of substantially identical solar cells which then can be assembled into arrays of various designs, as required, to achieve the desired electrical output. The invention is described with reference to producing dye solar cells.
US08574942B2 Method of forming silicon nanowires and method of fabricating lithium secondary battery using the same
A method of preparing a silicon nanowire and a method of fabricating a lithium secondary battery including the silicon nanowire are provided. The method of preparing a silicon nanowire may include forming a catalyst layer including metal particles separated from one another on a silicon layer, selectively etching the silicon layer contacting the metal particles, and removing the metal particles.
US08574941B2 Method for manufacturing solid-state imaging device
A method for manufacturing a solid-state imaging device in which a charge generator that detects an electromagnetic wave and generates signal charges is formed on a semiconductor substrate and a negative-charge accumulated layer having negative fixed charges is formed above a detection plane of the charge generator. The method includes the steps of: forming an oxygen-feed film capable of feeding oxygen on the detection plane of the charge generator; forming a metal film that covers the oxygen-feed film on the detection plane of the charge generator; and performing heat treatment for the metal film in an inactive atmosphere to thereby form an oxide of the metal film between the metal film and the oxygen-feed film on the detection plane of the charge generator, the oxide being to serve as the negative-charge accumulated layer.
US08574939B2 Semiconductor optoelectronics structure with increased light extraction efficiency and fabrication method thereof
A semiconductor optoelectronic structure with increased light extraction efficiency and a fabrication method thereof are presented. The semiconductor optoelectronic structure includes continuous grooves formed under an active layer of the semiconductor optoelectronic structure to reflect light from the active layer and thereby direct more light through a light output surface so as to increase the light intensity from the semiconductor optoelectronic structure.
US08574938B2 Using isolated epitaxial structures in glue bonding for multiple group-III nitride LEDS on a single substrate
A method for forming a plurality of semiconductor light emitting devices includes forming an epitaxial layer having a first type doped layer, a light emitting layer, and a second type doped layer on a first temporary substrate. The epitaxial layer is separated into a plurality of epitaxial structures on the first temporary substrate. A second temporary substrate is coupled to the epitaxial layer with a first adhesive layer and the first temporary substrate is removed from the epitaxial layer. A permanent semiconductor substrate is coupled to the epitaxial layer with a second adhesive layer. The second temporary substrate and the first adhesive layer are removed from the epitaxial layer. The permanent semiconductor substrate is separated into a plurality of portions with each portion corresponding to at least one of the plurality of epitaxial structures to form a plurality of semiconductor light emitting devices.
US08574937B2 High efficiency electroluminescent devices and methods for producing the same
Aspects of the disclosure include electroluminescent devices and methods for making the same. The devices include a substrate, a hole-injection electrode layer, an electroluminescent layer, and an electron-injection electrode layer, such as a layer that includes an air-stable, low work function material, which layer is capable of achieving efficient electron injection with reduced current leakage. In certain embodiments, the devices may contain an efficient electron injection layer that includes a composition comprising a polymer, e.g., a polymer that contains polar components (such as a polar functional group), and a metal diketonate. In certain embodiments, the devices may contain an electron injection layer that includes polyethylene glycol dimethyl ether and barium or calcium acetylacetonate. Methods of manufacturing such devices, for instance, employing a solution processing step for the deposition of an electron injection layer, as well as the use of the produced device(s) in electroluminescent displays is also provided herein.
US08574931B2 Singulation and strip testing of no-lead integrated circuit packages without tape frame
Strip testing is applied to a plurality of integrated circuit dies that are each encapsulated in an encapsulant, that each have a set of externally accessible leads connected thereto, and that are electrically isolated from one another. Provision is made for the strip testing to be performed without mounting the encapsulated integrated circuit dies on a support tape.
US08574928B2 MRAM fabrication method with sidewall cleaning
Fabrication methods for MRAM are described wherein any re-deposited metal on the sidewalls of the memory element pillars is cleaned before the interconnection process is begun. In embodiments the pillars are first fabricated, then a dielectric material is deposited on the pillars over the re-deposited metal on the sidewalls. The dielectric material substantially covers any exposed metal and therefore reduces sources of re-deposition during subsequent etching. Etching is then performed to remove the dielectric material from the top electrode and the sidewalls of the pillars down to at least the bottom edge of the barrier. The result is that the previously re-deposited metal that could result in an electrical short on the sidewalls of the barrier is removed. Various embodiments of the invention include ways of enhancing or optimizing the process. The bitline interconnection process proceeds after the sidewalls have been etched clean as described.
US08574923B2 Sample preparation device
A sample preparation device is disclosed. The sample preparation device includes a housing defining a passage way between a first opening and a second opening; and a sample filter occupying a section of said passage way. The sample filter contains a monolith adsorbent that specifically binds to nucleic acids. Also disclosed are sample filters containing glass frit is coated with an capture agent that binds specifically to an analyte of interest, sample filters containing a hydrophilic matrix with impregnated chemicals that lyses cell membranes, a cartridge base and an integrated sample preparation cartridge.
US08574921B2 Optical sensing membranes, devices and methods for simultaneous detection of two or more parameters of dissolved oxygen concentration, pH and temperature
Provided is an optical sensing membrane, including a mixture of two or more fluorescent dyes for detection of dissolved oxygen concentration, pH and temperature, immobilized on a support, a detection device including the optical sensing membrane and a detection method using the detection device.
US08574919B2 Mechanical cartridge with test strip fluid control features for use in a fluid analyte meter
A structure for controlling fluid flow from a sample receiving pad into a lateral flow assay test strip, including: a lateral flow assay test strip; a sample pad abutting the lateral flow assay test strip; a pinch wall positioned to direct fluid flow from the sample pad to the lateral flow assay test strip; a top support structure positioned on top of the test strip; and a bottom support structure positioned underneath the test strip, wherein each of the top and bottom support structures comprise a plurality of separate spaced-apart support ribs positioned along the length of the test strip.
US08574916B2 Melamine assay methods and systems
A method of detecting melamine which includes providing a quantity of SERS-active particles and mixing the SERS-active particles with a solution containing melamine. The method further includes detecting a surface enhanced Raman spectrum of the melamine. The foregoing method may optionally include aggregating the SERS-active particles. Aggregation may occur before or after the SERS-active particles are mixed with a solution containing melamine. The method of detecting melamine may optionally include concentration of the SERS-active particles. The method may further include mixing a chaotropic agent having a higher affinity for a selected binding site than melamine into the solution containing melamine. The method may further include mixing a quantity of a SERS-active standard having a known SERS spectrum with the solution containing melamine and SERS-active particles. Assay apparatus and systems are also disclosed.
US08574910B2 Site-specific integration and stacking of transgenes in soybean via DNA recombinase mediated cassette exchange
A targeting method is described that allows precise cassette replacement at a previously characterized genetic locus. A target DNA construct containing a pair of incompatible FRT sites flanking a target cassette was introduced into soybean by regular biolistic transformation. Transgenic events containing a single complete copy of the target site were then selected and retransformed with a donor DNA construct containing the identical pair of incompatible FRT sites flanking a donor cassette. Precise DNA cassette exchange happened between the target cassette and the donor cassette via recombinase mediated cassette exchange (RMCE) so that the donor cassette was introduced at the exact genomic site previously occupied by the target cassette. Through repeated RMCE using additional incompatible FRT sites, multiple groups of transgenes can be stacked at the same genomic locus.
US08574908B2 Plant cultivation method
A method for the production of young plants belonging to the group of herbaceous ornamentals, which method comprises an in vitro culture phase during which explants obtained from a parent stock of a species to be propagated, or derivatives of these explants, are subjected to micropropagation which is carried out under suitable conditions and on suitable culture media, in order to produce micro-plantlets which, when subjected to an in vivo culture phase, are intended to develop into a plant.
US08574903B2 Method for expanding monocytes
The invention relates to an ex vivo method for expanding monocytes, macrophages or dendritic cells, which method comprises inhibiting the expression or the activity of MafB and c-Maf in monocytes, macrophages or dendritic cells; and expanding the cells in the presence of at least one cytokine or an agonist of cytokine receptor signaling.
US08574902B2 Activated leukocyte composition and uses for wound healing
Disclosed are therapeutic, blood-derived activated leukocyte compositions, methods of making them, and methods of using the compositions to repair or promote the prevention and healing of wounds.
US08574894B2 Molecular dispensers
A molecular dispenser includes a molecular reservoir comprising a plurality of charged molecules; a nanopore proximate the molecular reservoir, the nanopore comprising a first set of locking electrodes configured to establish an electrostatic potential barrier therein and a second set of locking electrodes configured to establish a second electrostatic potential barrier therein; a first drag electrode arranged within the molecular reservoir; and a control unit, wherein the control unit is configured to apply an oscillating voltage across the first set of locking electrodes and a bias voltage to the first drag electrode to control flow of individually charged molecules from the molecular reservoir through the nanopore.
US08574882B2 Thermostable 1,5-anhydroglucitol dehydrogenase, and method for measurement of 1,5-anhydroglucitol by using the same
A protein comprising an amino acid sequence having at least one mutation selected from a Gly-4 to Ala mutation, a Glu-6 to His mutation, a Ser-14 to Thr mutation, an Ala-37 to Thr or Arg mutation, a Pro-50 to Gln mutation, a Glu-67 to Gly mutation, an Asp-80 to Tyr mutation, a Val-93 to Met mutation, an Arg-156 to Pro mutation, a Leu-164 to Met mutation, an Asn-202 to Asp mutation, a Thr-235 to Ala mutation, an Asn-348 to Tyr mutation, a Gly-362 to Arg mutation and a Val-473 to Ala mutation in the amino acid sequence depicted in SEQ II NO:4. (2) A thermostable protein which comprises an amino acid sequence derived from the amino acid sequence having at least one variation described in (1) and having 1,5-anhydroglucitol dehydrogenase activity. These proteins act specifically on 1,5-anhydroglucitol (1,5-AG), have thermal stability and exhibit excellent storage stability.
US08574880B2 Method for preparing a biocomposite comprising one or more enzymes
This invention relates to a method of immobilizing biocatalysts including protein and cells by co-precipitation with silicate or organosilicate matrices through the action of an organic template molecule. The organic template molecule is in general a polyamine such as polyethylenimine (PEI), or polypeptide compound bearing at least two or three basic residues selected from the group consisting of lysine, arginine, histidine, proline, hydroxyproline, N-methylhistidine, ornithine, taurine, δ-hydroxylysine, and δ-hydroxy-ω-N,N,N trimethyllysine. The invention is also directed to a silica biocomposite comprising co-precipitates of active biocatalysts, silica or organosilicates, and an N-containing organic template molecule. Such silica biocomposites are useful in biocatalysis, and other applications requiring an immobilized biocatalyst. Preferred biocatalysts for this invention are enzymes and whole cells.
US08574873B2 Process for the preparation of homopolysaccharides
A process for the preparation of aqueous solutions of glucans having a β-1,3-glycosidically-linked main chain and side groups having a β-1,6-glycosidic bond by fermentation of fungal strains. The fungal strains secrete the glucans into the fermentation broth, in an aqueous culture medium, and the separation of the glucans from the fermentation broth is effected using asymmetrical filter membranes.
US08574865B2 Methods and assays for identifying compounds that modulate protein-protein interactions
Methods and assays for identifying a compound that modulates a protein-protein interaction between a first and a second protein. The methods and assays require a protease that is attached to the second protein and a split and rearranged reporter activating protein that is attached to the first protein, wherein the reporter activating protein comprises a cleavage site for the protease that is interposed between two portions of the reporter activating protein and wherein the two portions of the reporter activating protein are in a rearranged order.
US08574864B2 Methods and kits for 3'-end-tagging of RNA
The present innovation provides methods and kits that enable rapid and efficient dual end-tagging of RNA to prepare libraries for analysis by applications such as next-generation RNA sequencing, qPCR, microarray analysis, or cloning. The methods do not require time-consuming and inefficient gel-purification steps that are common to methods known in the art. In addition, the present invention provides methods and kits for rapid, high-throughput enzymatic preparation of 5′-activated, 3′-blocked DNA oligonucleotides from standard, single-stranded DNA oligonucleotides.
US08574862B2 Methods and composition for measuring the amount of Vitamin D derivatives
Methods and compositions for measuring the amount of vitamin D derivatives are disclosed. Fluorescence Resonance Energy Transfer (FRET) in combination with a modified ligand-binding domain of the vitamin D receptor (LBD-VDR) to measure vitamin D derivatives are also disclosed.
US08574859B2 In vivo flow cytometry based on cellular autofluorescence
The present invention generally provides methods and systems for performing in vivo flow cytometry by using blood vessels as flow chambers through which flowing cells can be monitored in a live subject in vivo without the need for withdrawing a blood sample. In some embodiments, one or more blood vessels are illuminated with radiation so as to cause a multi-photon excitation of an exogenous fluorophore that was previously introduced into the subject to label one or more cell types of interest. In some other embodiments, rather than utilizing an exogenous fluorophore, endogenous (intrinsic) cellular fluorescence can be employed for in vivo flow cytometry. The emission of fluorescence radiation from such fluorophores in response to the excitation can be detected and analyzed to obtain information regarding a cell type of interest.
US08574856B2 Methods for determining the efficiency of a therapeutic
Methods for determining the efficiency of a therapeutic. In at least one embodiment of a method of determining the efficacy of a therapeutic compound, the method comprises the steps of treating a subject having a disease state with an effective amount of therapeutic compound, harvesting at least one cell from the subject following a treatment with the therapeutic compound, bringing the at least one cell into contact with a stabilizing compound capable of completely or substantially preventing the degradation or inactivation of a diagnostic marker for the disease state, analyzing the at least one stabilized cell for the at least one diagnostic marker, creating a marker profile from at least one result determined from analyzing the at least one stabilized cell, and comparing the marker profile with at least one previous marker profile to determine efficacy of the therapeutic compound on the disease state.
US08574855B2 Assays for the detection of anti-TNF drugs and autoantibodies
The present invention provides assays for detecting and measuring the presence or level of anti-TNFα drug therapeutics and autoantibodies in a sample. The present invention is useful for optimizing therapy and monitoring patients receiving anti-TNFα drug therapeutics to detect the presence or level of autoantibodies (e.g., HACA and/or HAHA) against the drug.
US08574853B2 Monoclonal antibodies that neutralize anthrax toxins
The present invention relates to monoclonal antibodies that bind or neutralize anthrax lethal factor (LF), edema factor (EF), and/or protective antigen (PA). The invention provides such antibodies, fragments of such antibodies retaining anthrax toxin-binding ability, fully human or humanized antibodies retaining anthrax toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
US08574852B2 Method for evaluating cell aging by expression level of cofilin
The present invention discloses a concept that the expression level of cofilin may reflect the senescent condition of a cell or tissue. According to the findings in present invention, a method for determining the cellular senescent condition in a cell or tissue sample by evaluating the expression level of cofilin is provided. The detection of the expression level of cofilin is also used to screen an effective compound or composition for regulating the senescent condition in target cells.
US08574847B2 Use of blocker oligonucleotides in selective amplification of target sequences
A method for the selective amplification of a target sequence. The method includes hybridizing a tagged oligonucleotide to the target sequence and reducing the effective concentration of unhybridized tagged oligonucleotide which is capable of hybridizing to the target sequence. The tagged oligonucleotide includes a target hybridizing sequence and a tag sequence situated 5′ to target hybridizing sequence, where the tag sequence does not stably hybridize to a target nucleic acid containing the target sequence. A blocker oligonucleotide is provided which is designed to hybridize to a region of a nucleic acid containing the target sequence, where the region targeted by the blocker oligonucleotide is 3′ to the target sequence. Amplification products are formed using first and second oligonucleotides. The first oligonucleotide hybridizes to the 3′-end of the complement of the target sequence, and the second oligonucleotide hybridizes to the complement of the tag sequence.
US08574845B2 Method for identifying an increased susceptibility to ulcerative colitis
A method is provided for detecting an increased susceptibility to ulcerative colitis by determining the presence of a polymorphism at position 256 of the nucleotide sequence of rs3024505 in which C is substituted by T or the presence of a polymorphism at position 501 of the nucleotide sequence of rs12612347 in which G is substituted by A.
US08574844B2 Quantitative real-time assay for Noroviruses and Enteroviruses with built in quality control standard
A method is provided for reverse transcription-polymerase chain reaction (RT-PCR) accomplished by: a) amplifying a reverse transcribed cDNA in a mixture containing Norovirus Genogroup I and Norovirus Genogroup II primers and probes, in which the Norovirus primers and probes can distinguish between Genogroup I and Genogroup II viruses; b) quantifying virus; and c) normalizing data based on a universal internal RNA control. Optionally, the method may also include primers and probes for Enteroviruses. The present invention also provides a reaction mixture containing Norovirus Genogroup I and Norovirus Genogroup II primers and probes, in which the Norovirus primers and probes can distinguish between Genogroup I and Genogroup II viruses and universal internal RNA control primers and probes.
US08574842B2 Direct molecular diagnosis of fetal aneuploidy
Methods and materials for detection of aneuploidy and other chromosomal abnormalities using fetal tissue are disclosed. Results can be obtained rapidly, without cell culture. The method uses digital PCR for amplification and detection of single target sequences, allowing an accurate count of a specific chromosome or chromosomal region. Specific polynucleic acid primers and probes are disclosed for chromosomes 1, 13, 18, 21, X and Y. These polynucleic acid sequences are chosen to be essentially invariant between individuals, so the test is not dependent on sequence differences between fetus and mother.
US08574830B2 Binding protein and epitope-blocking ELISA for the universal detection of H5-subtype influenza viruses
Monoclonal antibodies and related binding proteins specific to influenza H5 subtype HA protein can be used in serological diagnosis of influenza H5 infection in mammalian and avian serum samples, including human serum samples. Each antibody reacts strongly with a wide variety of strains of H5 subtype and does not show cross-reactivity with non-H5 influenza subtypes.
US08574822B2 Nanoimprint resist
A nanoimprint resist includes a hyperbranched polyurethane oligomer, a perfluoropolyether, a methylmethacrylate, a diluent solvent, and a photo initiator. The hyperbranched polyurethane oligomer can be polymerized by a copolymerization of trimellitic anhydride, ethylene mercaptan, and epoxy acrylic acid. The hyperbranched polyurethane oligomer can also be polymerized by a ring-opening copolymerization epoxy acrylic acid and ethylene glycol.
US08574816B2 Positive resist composition and patterning process
The invention provides a positive resist composition comprising, as base resins contained therein, (A) a polymer having a weight-average molecular weight of 1000 to 500000 and containing a repeating unit which contains a structure having a hydrogen atom of a carboxyl group thereof substituted with an acid-labile group having a cyclic structure and (B) a novolak resin of a substituted or an unsubstituted naphtholphthalein, and in addition, a photo acid generator. There can be provided a positive resist composition having an appropriate absorption to form a pattern on a highly reflective substrate, excellent characteristics in adhesion and implantation onto a non-planar substrate, a good pattern profile after light exposure, and an ion implantation resistance at the time of ion implantation; and a patterning process.
US08574815B2 Patterning nano-scale patterns on a film comprising unzipping copolymers
The invention concerns a method for patterning a surface of a material. A substrate having a polymer film thereon is provided. The polymer is a selectively reactive polymer (e.g., thermodynamically unstable): it is able to unzip upon suitable stimulation. A probe is used to create patterns on the film. During the patterning, the film is locally stimulated for unzipping polymer chains. Hence, a basic idea is to provide a stimulus to the polymeric material, which in turn spontaneously decomposes e.g., into volatile constituents. For example, the film is thermally stimulated in order to break a single bond in a polymer chain, which is sufficient to trigger the decomposition of the entire polymer chain.
US08574814B2 Actinic ray-sensitive or radiation-sensitive resin composition, and actinic ray-sensitive or radiation-sensitive film and pattern forming method using the composition
An object of the present invention is to provide an actinic ray-sensitive or radiation-sensitive resin composition that can form independent line patterns with high resolution and excellent shapes and shows excellent resist performances including roughness characteristics, and to provide an actinic ray-sensitive or radiation-sensitive film and a pattern forming method using the composition.The actinic ray-sensitive or radiation-sensitive resin composition contains a compound (P) that contains at least one phenolic hydroxyl group and at least one group in which a hydrogen atom of a phenolic hydroxyl group is substituted with a group represented by the following General Formula (1) (the respective symbols in the formula represent the same definitions as in the claims and the specification).
US08574812B2 Resist composition and method for producing resist pattern
A resist composition of the invention includes: (A1) a resin having a structural unit represented by the formula (I), (A2) a resin being insoluble or poorly soluble in alkali aqueous solution, but becoming soluble in an alkali aqueous solution by the action of an acid and (B) an acid generator represented by the formula (II), wherein R1, A1, R2, Q1, Q2, L1, ring W1, and Z+ are defined in the specification.
US08574809B2 Positive resist composition and method of forming resist pattern
The present invention provides a positive resist composition capable of forming a resist pattern with high resolution, and a method of forming a resist pattern.This composition is a positive resist composition including a resin component (A) which exhibits increased solubility in an alkali developing solution under action of acid, and an acid-generator component (B) which generates acid upon irradiation, the resin component (A) containing a polymer including: a core portion represented by general formula (1) [Chemical Formula 1] PX—Y)a   (1) wherein P represents an a-valent organic group; a represents an integer of 2 to 20; Y represents an arylene group or an alkylene group of 1 to 12 carbon atoms; and X represents a specific linking group which can be cleaved under action of acid, and arm portions that are bonded to the core portion and are also composed of a polymer chain obtained by an anionic polymerization method.
US08574808B2 Resin emulsion
The present invention relates to a resin emulsion being produced by neutralizing a resin binder containing acid group with a basic compound in an aqueous medium wherein the resin binder containing acid group contains a polyester produced from a raw monomer composition containing a trivalent or higher-valent polyhydric alcohol in an amount of 1 to 15 mol %; a process for producing the resin emulsion; and a toner for electrophotography using the resin emulsion. In the resin emulsion of the present invention, a resin is readily emulsified therein even when using a crosslinked polyester as the resin, and the resin emulsion is substantially free from hydrolysis of the resin and can produce a toner having an excellent heat-resistant storage property.
US08574804B2 Toner compositions and processes
Toners are provided, which possess low melt properties capable of producing a low gloss finish. The toners include a core and a shell. The shell includes a crystalline resin. The core may include at least one amorphous resin, an optional crystalline resin, an optional wax, and an optional colorant.
US08574800B2 Toner for electrostatic charge image development, electrostatic charge image developer, toner cartridge, process cartridge and image forming device
A toner for electrostatic charge image development includes toner particles and fatty acid metal salt particles. The content of the fatty acid metal salt particles is from 0.2 parts by weight to 5 parts by weight with respect to 100 parts by weight of the toner particles; the weight of fatty acid metal salt particles remaining on a sieve having an opening of 25 μm when the toner is sieved with the sieve having an opening of 25 μm is from 0.015% by weight to 0.300% by weight with respect to the total weight of the toner; and the weight of fatty acid metal salt particles remaining on a sieve having an opening of 45 μm when the toner is sieved with the sieve having an opening of 45 μm is 0.030% by weight or less with respect to the total weight of the toner.
US08574799B2 Electrophotographic photoreceptor
This invention provides an electrophotographic photoreceptor having improved resistance to soiling by a human body-derived substance and a high image stability. The electrophotographic photoreceptor comprises an electroconductie substrate and a photosensitive layer provided on the substrate and is characterized in that the photosensitive layer contains, as a binder resin, a polycarbonate resin comprising constituent units represented by the following formula (A) and the following formula (B), wherein R1 to R4 represent a hydrogen atom, a methyl group or the like; and X represents an alkylene group or the like. 3 to 50% by weight of the total constituent units is accounted for by the constituent units of formula (A) and the intrinsic viscosity is 0.3 to 2 dl/g. [Chemical formula 1] (A)(B).
US08574797B2 Electrophotographic photoconductor, process cartridge, and electrophotographic image-forming apparatus
An electrophotographic photoconductor includes a base, an undercoat layer that contains a metal oxide and an electron-accepting material and has a thickness of about 3 μm or more and about 15 μm or less, and a photosensitive layer containing a polymer having a repeating unit represented by general formula (1) where R1 and R2 each independently represent a halogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 5 to 7 carbon atoms, or an aryl group having 6 to 12 carbon atoms; and m and n each independently represent an integer of 0 to 4.
US08574796B2 ABS polymer containing photoconductors
A photoconductor that includes an optional anticurl layer, optional supporting substrate, an optional ground plane layer, an optional hole blocking layer, an optional ground strip segment, an optional adhesive layer, a photogenerating layer, and a charge transport layer that contains an acrylonitrile-butadiene-styrene polymer.
US08574795B2 Lithographic CD correction by second exposure
Correction of CD variation is accomplished with a second exposure, e.g. using a second reticle. Embodiments include exposing a first wafer with a first dose using a first reflective reticle having a pattern corresponding to a wafer target pattern, or measuring and/or inspecting first reticle pattern portions and calculating and/or simulating corresponding first wafer pattern portions obtained with a predetermined first dosage, identifying CD variations between the exposed wafer or the calculated/simulated first wafer pattern and the target pattern for different target pattern features, exposing a second wafer with the first reticle using a second dose, and correcting the CD variations by applying an additional exposure of the second wafer, before or after exposing the second wafer with the first reticle. Embodiments further include using additional exposures to prevent printing unwanted structures on the reticle or to deliberately vary sizes of selected structures on the wafer for development purposes.
US08574793B2 Mask blank, transfer mask, method of manufacturing a transfer mask, and method of manufacturing a semiconductor device
A mask blank for use in the manufacture of a transfer mask adapted to be applied with ArF excimer laser exposure light is disclosed. The mask blank has, on a transparent substrate, a light-shielding film for forming a transfer pattern. The light-shielding film has an at least two-layer structure including a lower layer and an upper layer from the transparent substrate side. The lower layer is made of a material composed of a transition metal, silicon, and nitrogen and having a nitrogen content of 21 at % or more and a refractive index n of 1.9 or less. The upper layer is made of a material composed of a transition metal, silicon, and nitrogen and having a refractive index n of 2.1 or less. A surface layer of the upper layer contains oxygen and has a nitrogen content of 14 at % or more.
US08574792B2 Photomask including super lens and manufacturing method thereof
A photomask includes a substrate, a mask pattern layer and a super lens. The substrate includes a pattern which includes protruding portions, and open portions between the protruding portions. The mask pattern layer is in the open portions of the pattern and fills the open portions of the pattern. The super lens is on the substrate and the mask pattern layer.
US08574788B2 Fuel cell system including gas exhaust and water flow paths and insulator
A fuel cell system includes: a gas exhaust flow path extended in a stacking direction of laminates and configured to have one end located inside a fuel cell stack and the other end located outside the fuel cell stack; and a water discharge flow path provided at a lower position than the gas exhaust flow path and formed to pass through at least part of the laminates. The gas exhaust flow path is interconnected with the water discharge flow path via at least one connecting section in the fuel cell stack. The gas exhaust flow path includes a narrowed flow path having the smaller sectional area than the sectional area of an adjacent flow path in downstream of the connecting section. The water discharge flow path has a downstream end connecting with the narrowed flow path.
US08574787B2 Fuel cell stack
A fuel cell stack includes a plurality of fuel cells stacked together, and a pair of end plates provided at opposite ends the fuel cells in the stacking direction. Further, the fuel cell stack includes coupling members bridging between the end plates, holding mechanisms provided in side surfaces of the end plates and the coupling members for applying tension in a tightening direction, and fixing mechanisms for fixing the side surfaces of the end plates and the coupling members together. The holding mechanism has a pin member inserted into the side surface of the end plate and the coupling member. Further, the fixing mechanism has a screw for fixing the coupling member to the side surface of the end plate.
US08574783B2 Fuel cell stack including buffer protrusion system in connection channel
A fuel cell stack including membrane-electrode assemblies and separators formed between each of the membrane-electrode assemblies is disclosed. The membrane-electrode assemblies may each include an electrolyte membrane, an anode formed on a first surface of the electrolyte membrane, and a cathode formed on a second surface of the electrolyte membrane. Each of the separators may include an anode separator facing the anode and a cathode separator facing the cathode. Each of the separators may include at least two manifolds, a channel separated from the manifolds and facing either the anode or the cathode, and a connection channel fluidly connecting the manifold and the channel. The separator may also include a buffer protrusion system in the connection channel configured to disperse the flow of the fuel or the oxidant.
US08574778B2 Fuel cell stack
A fuel cell stack includes a first end power generation unit and a first dummy unit adjacent to a power generation unit at one end of a stack body in a stacking direction. In the first end power generation unit, a first separator is stacked on the power generation unit, a first membrane electrode assembly is stacked on the first separator, a second separator is stacked on the first membrane electrode assembly, an electrically conductive plate is stacked on the second separator, and a third separator is stacked on the electrically conductive plate. A coolant is supplied to a coolant flow field formed between the power generation unit and the first end power generation unit, for cooling a second membrane electrolyte assembly of the power generation unit and the first membrane electrode assembly of the first end power generation unit.
US08574775B2 Fuel cell system and method for starting up the same
A method for starting a fuel cell system may include raising the temperature of the reforming catalyst layer while measuring the temperature of the reforming catalyst layer, calculating the flow rate of a hydrocarbon fuel which can be reformed in the reforming catalyst layer based on the measured temperature of the reforming catalyst layer, and supplying the hydrocarbon fuel at the calculated flow rate into the reforming catalyst layer to reform the fuel, and supplying the resultant reformed gas into an anode of a high temperature-type fuel cell. The amount of the hydrocarbon fuel supplied into the reforming catalyst layer is increased until the amount of the hydrocarbon fuel supplied into the reforming catalyst layer reaches the flow rate at the time of the completion of the start.
US08574774B2 Negative electrode and aluminum air cell
There is provided a negative electrode comprising an aluminum alloy, wherein the alloy has a magnesium content of 0.0001% by weight or higher and 8% by weight or lower, the alloy satisfies at least one condition selected from the group consisting of the following (A) and (B): (A) an iron content is 0.0001% by weight or higher and 0.03% by weight or lower, and (B) a silicon content is 0.0001% by weight or higher and 0.02% by weight or lower, and a content of each element other than aluminum, magnesium, silicon and iron in the alloy is 0.005% by weight or lower.
US08574773B2 Battery electrolyte solutions containing aromatic phosphorus compounds
A battery electrolyte solution contains from 0.01 to 80% by weight of an aromatic phosphorus compound. The aromatic phosphorus compound provides increased thermal stability for the electrolyte, helping to reduce thermal degradation, thermal runaway reactions and the possibility of burning. The aromatic phosphorus compound has little adverse impact on the electrical properties of the battery, and in some cases actually improves battery performance.
US08574771B2 Rechargeable lithium battery
A rechargeable lithium battery is provided. The battery includes an electrolyte including a lithium salt, a non-aqueous organic solvent including an ethylene carbonate-based compound and a pyrocarbonate-based additive; a negative electrode that includes a negative active material including a crystalline-based carbon core and an amorphous-based carbon shell surrounding the crystalline-based carbon core; and a positive electrode comprising a positive active material.
US08574768B2 Power storage device
An embodiment of the present invention relates to a power storage device which includes a positive electrode having a positive-electrode current collector with a plurality of first projections, a first insulator provided over each of the plurality of first projections, and a positive-electrode active material provided on a surface of the first insulator and the positive-electrode current collector with the plurality of first projections; a negative electrode having a negative-electrode current collector with a plurality of second projections, a second insulator provided over each of the plurality of second projections, and a negative-electrode active material provided on a surface of the second insulator and the negative-electrode current collector with the plurality of second projections; a separator provided between the positive electrode and the negative electrode; and an electrolyte provided in a space between the positive electrode and the negative electrode and containing carrier ions.
US08574764B2 Negative active material including silicon active particles surrounded by copper, aluminum and tin metal matrix and rechargeable lithium battery including the same
A negative active material for a rechargeable lithium battery includes Si active particles, and a 3-component to 7-component metal matrix that surrounds the active fine particles without reacting therewith. The negative active material shows high capacity and improved cycle-life characteristics.
US08574761B2 Battery
A battery including a positive electrode, a negative electrode and an electrolytic solution, wherein the negative electrode has a negative electrode active material layer containing a carbon material and a binder and having a thickness per one face of 70 μm or more and not more than 120 μm; and the binder contains a copolymer A which is obtained by copolymerizing 100 parts by weight of polyvinylidene fluoride (PVDF) and from 0 to 4 parts by weight of hexafluoropropylene (HFP) and a copolymer B which is obtained by copolymerizing 100 parts by weight of polyvinylidene fluoride and from 5 to 12 parts by weight of hexafluoropropylene in a mass content ratio of A/B of from 60/40 to 90/10.
US08574758B2 Porous electrode substrate and method for producing the same
The present invention provides a porous electrode substrate that has low production cost, high mechanical strength, thickness precision, and surface smoothness, and sufficient gas permeability and electrical conductivity, and a method for producing the same. In the present invention, for example, a porous electrode substrate that includes short carbon fibers (A) joined together via three-dimensional mesh-like carbon fibers (B) is produced by a method including a step (1) of dispersing short carbon fibers (A), and short carbon fiber precursors (b) to be fibrillated by beating, to produce a precursor sheet; and a step (2) of subjecting the precursor sheet to carbonization treatment at a temperature of 1000° C. or higher.
US08574756B1 Prismatic secondary battery
A prismatic secondary battery includes a flat electrode assembly including one end having stacked positive electrode substrate exposed portions and including the other end having stacked negative electrode substrate exposed portions, and includes a positive electrode collector and a negative electrode collector connected to the corresponding outermost surface in the stacking direction of the stacked positive electrode substrate exposed portions and the stacked negative electrode substrate exposed portions, respectively, by resistance welding; the positive electrode substrate and the negative electrode substrate have thicknesses different from each other; a rib of the positive electrode collector and a rib of the negative electrode collector have heights different from each other; and each leading end in the height direction of the ribs has approximately the same height.
US08574753B2 Battery comprising a conductive nipping member
According to one embodiment, a battery includes an electrode group, a tab, a conductive nipping member, a case, a lid and a lead. The conductive nipping member includes first and second nipping sections. The first and second nipping sections divide the tab into two bundles in which portions of the tab are laminated onto each other in a thickness direction of the electrode group. The lead includes a connecting section connected electrically to a terminal, and current collecting sections which are two sections branched from the connecting section and sandwiching the nipping member.
US08574752B2 Electrode assembly and rechargeable battery using the same
A rechargeable battery includes an electrode assembly including a positive electrode including a positive current collector, a positive active material on the positive current collector in a positive coating region, and a positive uncoated region in which the positive active material is not on the positive current collector at a first side of the electrode assembly; a negative electrode including a negative current collector, a negative active material on the negative current collector in a negative coating region, a first negative uncoated region in which the negative active material is not on the negative current collector at the first side of the electrode assembly, and a second negative uncoated region in which the negative active material is not on the negative current collector at a second side of the electrode assembly opposite the first side; and a separator between the positive electrode and the negative electrode.
US08574751B2 Secondary battery with protective circuit board and secondary protective element
A secondary battery with a protective circuit module including a rechargeable bare cell having a first electrode and a second electrode and a protective circuit board having a protective circuit for the rechargeable bare cell. A conductive bonding layer is located on the protective circuit board and a secondary protective element assembly is attached to the protective circuit board by the conductive bonding layer. A first lead plate electrically connects the secondary protective element assembly to the first electrode, and a second lead plate electrically connects the protective circuit board to the second electrode.
US08574750B2 Sealed battery to withstand internal pressures and battery module using same
A sealed rectangular battery excellent in volumetric efficiency and pressure resistance is provided. The sealed rectangular battery includes an electrode group having a positive electrode and a negative electrode and a cell casing for accommodating therein the electrode group and an electrolyte solution, which casing includes a rectangular frame member, a first lid member and a second lid member. Each of the first and second lid members includes a body portion for covering one of the openings of the frame member, and a side portion formed so as to protrude from the body portion substantially along at least one set of sides opposite to each other.
US08574749B2 Lithium secondary battery
A lithium secondary battery including: an electrode assembly including a center pin inside of the electrode assembly; a can including the electrode assembly; and a cap assembly coupled to a side of the can. At least one end of the center pin includes a deforming end to deform due to an impact power caused by a collision of the deforming end with an inner surface of the can and/or the cap assembly, preventing the center pin from protruding to an outside of the can and/or the cap assembly. Accordingly, the lithium secondary battery is safer by preventing a center pin from protruding when the cylindrical lithium secondary battery explodes due to an increase in internal pressure.
US08574747B2 Car power source apparatus
A car power source apparatus has a battery block (2) including a plurality of connected batteries (1), a battery state detection section (3) connected to the battery block, a base-plate (4) having the battery state detection section and battery block mounted thereon, a cover-plate (5) that closes-off the top of the base-plate, and side-plates (6) that close-off open regions between the cover-plate and the base plate. The cover-plate is provided with a top cover (7) that establishes an interior battery holding region (12), and an electronic component cover (8) that establishes an interior electronic component compartment (13). The edges at ends of the cover-plate have end edge-covers (7X, 8X) that extend downward along the outer surfaces of the side-plate. The end edge-covers make the connection between the cover-plate and the side-plate water-tight.
US08574745B2 Resin composition and organic-electrolyte battery
Provided is a resin composition superior in the adhesiveness to a metal and having high organic solvent resistance, particularly, a resin composition preferable as a sealant for an organic electrolyte battery, which shows superior adhesiveness to a terminal or a collector made of a highly heat resistant metal such as stainless steel and nickel, does not easily develop degradation even when contacted with an organic electrolytic solution at a high temperature, and does not easily influence an electrolytic solution, and a highly reliable organic electrolyte battery wherein leaching of an electrolytic solution from an electrolyte layer is prevented by the resin composition.A resin composition containing (A) an epoxy resin containing at least (E1) an epoxy resin having an aromatic ring and an alicyclic skeleton and (B) a latent curing agent.
US08574741B2 Method for controlling sodium-sulfur battery
A method for controlling a plurality of sodium-sulfur batteries that, in an interconnected system in which a power generation device that fluctuates in output and an electric power storage-compensation device are combined to supply power to an electric power system, are each included in the electric power storage-compensation device and compensate for output fluctuations of the power generation device, is provided. When one sodium-sulfur battery of the plurality of sodium-sulfur batteries reaches a discharge end, the sodium-sulfur battery reaching the discharge end is charged from a sodium-sulfur battery other than the sodium-sulfur battery reaching the discharge end. When one sodium-sulfur battery of the plurality of sodium-sulfur batteries reaches a charge end, the sodium-sulfur battery reaching the charge end is discharged to charge a sodium-sulfur battery other than the sodium-sulfur battery reaching the charge end.
US08574735B2 Battery pack
The battery pack is provided with an analog front-end that detects battery voltage, and a micro-controller connected to the analog front-end that accepts analog voltage signals from the analog front-end as input. The micro-controller switches voltage signals input from the analog front-end to determine failure of the analog front-end or the micro-controller.
US08574732B1 Hazard mitigation within a battery pack using metal-air cells
A system and method for mitigating the effects of a thermal event within a battery pack is provided in which the hot gas and material generated during the thermal runaway of at least one non-metal-air cell of a plurality of non-metal-air cells is directed through one or more metal-air cells, the metal-air cells absorbing at least a portion of the thermal energy generated during the event before it is released to the ambient environment. As a result, the risks to vehicle passengers, bystanders, first responders and property are limited.
US08574729B2 Magnetic structure including two ferromagnetically coupled magnetic layers and method of manufacturing same
A magnetic structure includes a first magnetic layer, a nonmagnetic insulating layer, a nonmagnetic adhesion layer disposed on the top surfaces of the first magnetic layer and the nonmagnetic insulating layer, and a second magnetic layer disposed on the nonmagnetic adhesion layer. The nonmagnetic insulating layer contains an oxygen atom. The nonmagnetic adhesion layer is composed of one element or a plurality of elements selected from the group consisting of Al, Si and nonmagnetic transition metal elements except Ru, and the bond enthalpy of a diatomic molecule composed of an atom of the one element or each of the plurality of elements and an oxygen atom is 400 kJ/mol or higher. The nonmagnetic adhesion layer has a thickness within a range of 0.3 to 0.8 nm. The first magnetic layer and the second magnetic layer are ferromagnetically coupled to each other.
US08574728B2 Aluminum oxynitride coated article and method of making the same
A coated article such as a coated cutting tool or coated wear part, which includes a substrate and a coating scheme on the substrate. The coating scheme has a titanium-containing coating layer, and an aluminum oxynitride coating layer on the titanium-containing coating layer. The aluminum oxynitride includes a mixture of phases having a hexagonal aluminum nitride type structure (space group: P63mc), a cubic aluminum nitride type structure (space group: Fm-3m), and optionally amorphous structure. The aluminum oxynitride coating layer has a composition of aluminum in an amount between about 20 atomic percent and about 50 atomic percent, nitrogen in an amount between about 40 atomic percent and about 70 atomic percent, and oxygen in an amount between about 1 atomic percent and about 20 atomic percent. The method of making the coated article includes a step of providing a substrate and depositing an aluminum oxynitride coating layer from a gaseous mixture that includes nitrogen, aluminum tri-chloride, ammonia, carbon dioxide, hydrogen chloride, optionally carbon monoxide, optionally argon, and hydrogen.
US08574725B2 Organic el element and solution containing organic el material
An organic electroluminescence device includes: an anode; a cathode; and an organic thin-film layer interposed between the anode and the cathode. The organic thin-film layer includes a phosphorescent-emitting layer containing a host and a phosphorescent dopant. The host contains a first host and a second host. The first host includes a substituted or unsubstituted polycyclic fused aromatic skeleton, the skeleton having 10 to 30 ring-forming atoms not including an atom of a substituent. The second host has an affinity level greater than the affinity level of the first host.
US08574717B2 Rubber laminate
Disclosed is a rubber laminate containing an unvulcanized fluororubber composition comprising: (A) fluororubber comprising a terpolymer containing 50 to 60 mol % of a constitutional unit derived from vinylidene fluoride, 20 to 30 mol % of a constitutional unit derived from tetrafluoroethylene, and 10 to 30 mol % of a constitutional unit derived from hexafluoropropene; (B) an oxide and/or hydroxide of a divalent metal; (C) a polyhydroxy aromatic compound; (D) a 2-substituted-4,6-dithiol-s-triazine derivative; (E1) a quaternary phosphonium salt or a tetraalkyl ammonium salt; (E2) 1,8-diazabicyclo[5.4.0]undecene-7 (salt); and (E3) a 5-substituted-1,5-diazabicyclo[4.3.0]-5-nonene (salt). In this rubber laminate, the fluororubber layer and the NBR layer are firmly vulcanization-bonded to each other without impairing various excellent characteristics of the fluororubber constituting the rubber layer.
US08574716B2 Ionic polymer devices and methods of fabricating the same
An ionic polymer composite device and methods for fabricating the ionic polymer composite device are provided. The ionic polymer composite device includes two extended electrode layers, each extended electrode layer including at least one ionic polymer with a plurality of electrically conductive particles, and a dielectric layer including at least one sulfonated poly ether sulfone polymer or a derivative between the two extended electrode layers.
US08574711B2 Structural or chassis part of a motor vehicle
The invention relates to a structural or chassis component of a motor vehicle, said structural or chassis component consisting of a composite material comprising an outer metallic layer, a middle plastics or plastics foam layer and an outer fiber-reinforced plastics layer. The object of providing a structural or chassis component which allows a further reduction in weight to be made without adversely affecting the load bearing capacity characteristics is achieved in that the thickness of the middle plastics layer is at least 0.2 mm.
US08574708B2 Thin chip resistant powder topcoats for steel
The present invention provides chip-resistant powder topcoats for corrosion resistant powder coated steel substrates, such as, for example, automotive suspension coil springs, comprising powder coatings formed from one or more wax and a resin component of one or more toughened epoxy resin. The present invention provides dual coatings of toughened epoxy powder basecoats and topcoats, which may be foamed and/or fiber reinforced. The powder used to form the chip resistant topcoat can further comprise up to 200 phr or, preferably, up to 75 phr of one or more extender, or 0.5 or more phr of one or more extender, such as barium sulfate, while fully retaining its chip resistant properties. In addition, the powder used to form the chip resistant topcoat can be a low temperature curing powder comprising one or more low temperature curing agent. The invention provides methods for making the dual coatings comprising applying to the substrate a toughened, zinc-loaded, epoxy coating powder, applying to the powder coated substrate a wax containing toughened epoxy topcoat and heating to fuse or cure the coating powders.
US08574706B2 Sound reducing wedge shaped polymer interlayers
The present invention is in the field of polymer interlayers and multiple layer glass panels comprising polymer interlayers, and, more specifically, the present invention is in the field of wedge shaped polymer interlayers.
US08574702B2 Shell structure and manufacturing method for shell structure of electronic device
A shell structure includes a composite material layer and a second material layer is provided. The composite material layer includes a woven layer and a first material layer. The woven layer has a first surface and a second surface opposite to each other. The first material layer is located on the first surface and has a plurality of through-holes. The second material layer is disposed on the first material layer and has a plurality of extending-portions adapted to be combined with the woven layer and fix the second material layer and the composite material layer to each other. In addition, a manufacturing method for shell structure of electronic device is also provided.
US08574701B2 Protective bumper device
A protective bumper device for attachment to an upright member, the device including a flexible base having a first surface for receipt against an upright member and an opposing second surface carries at least one elongated bumper member having a first end and a second end. An aperture extends through the elongated bumper member from the first end to the second end. A strap member extends through the aperture a first end and a second end extending beyond the ends of the elongated bumper member. A fastening mechanism including an engagement element and a complemental engagement element is attached to the ends of the strap member for releasable engagement.
US08574695B2 Biodegradable composite barrier film
The present invention is directed to a multilayer film having, as its main component, a hydroxy acid polymer with improved gas barrier and optional heat sealability. The oriented film of predominately hydroxy acid polymer having controlled shrink can be produced by melting and coextruding a hydroxy acid polymer with a much thinner layer of an amorphous aromatic copolyester to form a multilayer film that is quench cooled, then biaxially stretched at a process temperature above the glass transition and below the cold crystallization temperature of the hydroxy acid polymer. A heat-setting treatment with a controlled relaxation of the film above the hydroxy acid polymer glass transition temperature and below its melt temperature may be used to control shrinkage. The films thus obtained are vacuum metallized on the aromatic copolyester surface to produce environmentally friendly packaging from predominately renewable resources having improved gas barrier properties.
US08574691B2 Starch-based adhesive compositions and use thereof
An improved adhesive composition having increased bond strength between a celluosic board and plastic film substrate is provided. The adhesive composition having improved adhesion includes a modified starch component, polyethylenimine and water. Articles having improved adhesion and methods of making the articles having improved adhesion are also provided.
US08574690B2 Printable substrates with improved dry time and acceptable print density by using monovalent salts
An article in the form of a paper substrate having a first surface and a second surface; an internal paper sizing agent present in an amount sufficient to impart to the paper substrate an HST value of from about 50 to about 250 seconds; and a metal salt drying agent having at least about 20% by weight of one or more monovalent metal drying salts, wherein the metal salt drying agent is present on at least one of the first and second surfaces in an amount sufficient to provide a percent ink transferred (“IT %”) value equal to or less than about 65% and to provide a black print density value of at least about 1.45. Also, a method for treating the internally sized paper substrate having the HST value of from about 50 to about 250 seconds with the metal salt drying agent.
US08574688B2 Blue phase liquid crystal composition
The present invention relates to a blue phase liquid crystal composition and to a method of stabilizing a blue phase state of a liquid crystal material. Moreover, the present invention also relates to a method of lowering the operating voltage of a liquid crystal material. Furthermore, the present invention relates to a blue phase liquid crystal material stabilized by the method according to the present invention or having an operating voltage that is lowered by the method according to the present invention. Furthermore, the present invention relates to a liquid crystal cell comprising a blue phase liquid crystal material and to a liquid crystal display comprising a blue phase liquid crystal material. The present invention also relates to a method of broadening the stability temperature range of a liquid crystal material in its blue phase state.
US08574687B2 Method and device for depositing a non-metallic coating by means of cold-gas spraying
In a method for depositing a non-metallic, in particular ceramic, coating on a substrate (2) by cold gas spraying, the method has the steps of: producing a reactive gas flow (5) having at least one reactive gas, injecting into the reactive gas flow (5) particles (4) consisting of at least one material required for producing a non-metallic, in particular ceramic, coating material by reaction with the reactive gas, so as to form a mixture flow of reactive gas and particles (4), producing reactive gas radicals in the mixture flow, and directing the mixture flow having reactive gas radicals and particles onto a surface of a substrate (2) to be coated, and so a non-metallic, in particular ceramic, coating is deposited on the surface of the substrate (2). In addition, a description is given of a device (1) for carrying out the method.
US08574681B2 Ceramic composite thin films
A ceramic composite thin film or layer includes individual graphene oxide and/or electrically conductive graphene sheets dispersed in a ceramic (e.g. silica) matrix. The thin film or layer can be electrically conductive film or layer depending the amount of graphene sheets present. The composite films or layers are transparent, chemically inert and compatible with both glass and hydrophilic SiOx/silicon substrates. The composite film or layer can be produced by making a suspension of graphene oxide sheet fragments, introducing a silica-precursor or silica to the suspension to form a sol, depositing the sol on a substrate as thin film or layer, at least partially reducing the graphene oxide sheets to conductive graphene sheets, and thermally consolidating the thin film or layer to form a silica matrix in which the graphene oxide and/or graphene sheets are dispersed.
US08574680B2 Materials and methods for immobilization of catalysts on surfaces and for selective electroless metallization
A method of rendering a substrate catalytic to electroless metal deposition comprising the steps of: (a) depositing a ligating chemical agent on the substrate, which is capable of both binding to the substrate and ligating to an electroless plating catalyst; and (b) ligating the electroless plating catalyst to the ligating chemical agent,wherein the ligating chemical agent has the chemical structure:
US08574677B2 Layer-by-layer fabrication method of sprayed nanopaper
A layer-by-layer fabrication method of sprayed nanopaper is disclosed in the present invention. According to one embodiment, a plurality of nano-micro particles are suspended in a solvent to form a sprayable particle precursor. Afterwards, one or more sprayed nanopapers are formed by vacuum-assisted layer-by-layer spray of the sprayable particle precursor on a porous substrate.
US08574676B2 Substrate processing method
A substrate processing method includes steps of: arranging a substrate in a chamber; introducing H2 gas at a first flow rate and O2 gas at a second flow rate independently from the H2 gas into a catalyst reaction portion in which catalyst is accommodated, wherein H2O gas produced from the H2 gas and the O2 gas that contact the catalyst is ejected from the catalyst reaction portion toward the substrate; and reducing a flow rate of the O2 gas introduced to the catalyst reaction portion to a third flow rate that is lower than the second flow rate, wherein the steps of introducing the H2 gas and the O2 gas and reducing the flow rate of the O2 gas are repeated in this order at a predetermined repetition frequency, thereby processing the substrate.
US08574671B2 Method for adjusting the coolant consumption within actively cooled components, and component
A method for adjusting the coolant consumption within actively cooled components is produced. The components include an interior with at least one duct with different regions which have different cross sections of flow. A greater increase in the wall thickness is produced in the region having the smaller cross section of flow by a first diffusion process and a lesser increase in the wall thickness is produced in the region having the larger cross section of flow by a second diffusion process which is different from the first. By using different diffusion coatings in a component, it is possible to adjust the flow of coolant through a component in a controlled way.
US08574669B2 Method for producing polymer fine particle comprising contacting an emulsion with a poor solvent
A fine polymer particle production method includes producing an emulsion in a liquid prepared by dissolving and mixing a polymer A and a polymer B in organic solvents in which a solution phase composed primarily of the polymer A and a solution phase composed primarily of the polymer B are formed as separate phases, and bringing it into contact with a poor solvent for the polymer A to precipitate the polymer A. This method serves for easy synthesis of fine polymer particles with a narrow particle size distribution and the method can be effectively applied to production of highly heat-resistant polymers that have been difficult to produce with the conventional methods.
US08574665B2 Palladium precursor composition
A palladium precursor composition contains a palladium salt and an organoamine. The composition permits the use of solution processing methods to form palladium layers.
US08574664B2 Electrolyte membrane, methods of manufacture thereof and articles comprising the same
Disclosed herein is a method of forming an electrolyte membrane comprising forming a mixture; the mixture comprising a polyhydroxy compound, an aromatic polyhalide compound and an alkali metal hydroxide; disposing the mixture on a porous substrate; reacting the mixture to form a crosslinked proton conductor; and sulfonating the proton conductor. Disclosed herein too is an article comprising a porous substrate; and a sulfonated crosslinked proton conductor disposed within pores of the porous substrate.
US08574662B2 Substrate section for flexible display device, method of manufacturing substrate section, and method of manufacturing organic light emitting display device including substrate
A substrate section for a flexible display device is disclosed. The substrate section prevents adhesion loss between a reinforcing layer and a barrier layer, thereby preventing a peel-off phenomenon between an inorganic barrier layer and a reinforcing layer.
US08574661B2 Process for producing organic electroluminescent element and organic electroluminescent display device
This invention provides a process for producing an organic EL element that, in forming, by a coating method, an organic EL element comprising a substrate bearing a plurality of organic EL elements each comprising at least a first electrode, one or more organic compound layers, a second electrode, and a sealing layer, can easily form an external connection terminal forming part for external connection terminal formation and can realize high production efficiency and stable performance quality. The process for producing an organic EL element is a process for producing an organic EL element comprising a substrate bearing at least one organic EL element comprising at least a first electrode (an anode layer), at least one organic compound layer, a second electrode (a cathode layer), and a sealing layer and is characterized by comprising a masking member application step of laminating a masking member having an adhesive strength of 1 N/25 mm to 10 N/25 mm onto the organic compound layer formation prohibition region on the substrate, an organic compound layer formation step of forming the organic compound layer on the substrate, and a masking member separation step of separating the masking member.
US08574658B1 Fumeless latent fingerprint detection
A fumeless latent fingerprint detection system using fluorescent particles.
US08574656B2 High-purity Rebaudioside D and low-calorie fruit juice containing the same
The invention provides methods of purifying Rebaudioside D from the Stevia rebaudiana Bertoni plant extract along with Rebaudioside A. The methods are useful for producing high purity Rebaudioside D and Rebaudioside A. The invention further provides a low-calorie fruit juice containing the purified Rebaudioside D and a process for making the low-calorie fruit juice containing the purified Rebaudioside D.
US08574652B2 Method for smoke-infusing crustaceans or mollusks or fish
A method of smoke-infusing proteinaceous foods comprises the following sequential steps: a) enclosing the proteinaceous foods in a vacuum-treating zone; b) introducing smoke directly or indirectly from a smoke generation zone into the vacuum-treating zone; c) subjecting the proteinaceous foods to vacuum purging at a negative pressure in the vacuum-treating zone, thereby infusing smoke into the proteinaceous foods; d) repeating the steps of introducing smoke directly or indirectly from the smoke generation zone into the vacuum-treating zone; subjecting the proteinaceous foods to vacuum purging at a negative pressure in the vacuum-treating zone at least fifty times in pulsed sequences of smoke introduction stage/vacuum purging stage/vacuum release stage for the efficient infusion of smoke into the proteinaceous foods; and e) a post-chill resting cycle of the smoke-infused proteinaceous foods at a suitable temperature and for a suitable period of time.
US08574648B2 Method and apparatus for smoking food products
A method and apparatus for smoking food products includes a method or apparatus configured to provide a pH level of a smoked food product. The determination of the pH level of the smoked product provides an objective measure of the amount of smoke received by the food product, as well as an indication of the agreeability of the flavor of the food product. Based on the determination of the pH level, the method and apparatus can be adjusted to provide a more consistent, high quality smoked food product.
US08574644B2 Soluble oat flour and method of making utilizing enzymes
Producing soluble oat or barley flour by using enzymes to precondition whole oat or barley flour prior to an extrusion (continuous cooking) process.
US08574640B2 Combined effects of nutrients on proliferation of stem cells
A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
US08574637B2 Plant derived seed extract rich in essentially fatty acids derived from Salvia hispanica L. seed: composition of matter, manufacturing process and use
A Salvia hispanica L. derived seed oil extract composition of matter containing from 60-88% PUFAS in a ratio of from 3.1:1-3.3:1 of ALA to LA, 4-10% of C-18 mono-unsaturated fatty acid, 1-5% of C-18 saturated fatty acid and 4-8% of C-16 saturated fatty acid in a mixed triglyceride form stable at room temperature of 12-24 months containing a mixture of selected antioxidants.
US08574636B2 Herbal formulations
Provided is a formulation including a variety of Chinese herbs for the treatment of a disease, such as cancer, and side effects associated with the treatment of the disease.
US08574635B2 Compositions and methods for treating obesity, obesity related disorders and for inhibiting the infectivity of human immunodeficiency virus
The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues.
US08574633B2 Huperzia serrata (Thunb.) Trev. composition comprising compounded Huperzine A and Huperzine B and methods for preparing it
The invention is directed to the field of natural medicine, specifically to alkaloid extracts of Huperzia serrata (Thunb.) Trev. A Huperzia serrata (Thunb.) Trev. composition and the method for preparing it are provided. The Huperzia serrata (Thunb.) Trev. composition comprises Huperzine A and Huperzine B, wherein the total content of the said Huperzine A and Huperzine B is 50-99 wt % of total alkaloids and the weight ratio of the said Huperzine A and Huperzine B is 1:0.5-5. The Huperzia serrata (Thunb.) Trev. composition of the invention has good therapeutic effect and improved safety.
US08574632B2 Acidic oxidant-containing composition having aluminum corrosion-suppressing effect and use thereof
The invention provides a liquid composition containing (a) an acidic oxidant, (b) nitric acid or a salt thereof, and (c) at least one carboxylic acid selected from the group consisting of monocarboxylic acids, dicarboxylic acids, and tricarboxylic acids, or a salt thereof. The liquid composition can be used to disinfect or sterilize a subject that includes a portion made of an aluminum-based metal.
US08574626B2 Osmotic device containing amantadine and an osmotic salt
The osmotic devices of the present invention contain a unitary core comprising a salt of amantadine and an osmotic salt, wherein the two salts have an ion in common. The release rate of the amantadine is a sigmoidal release. The osmotic device includes a semipermeable membrane having a controlled porosity that can be adapted as needed to cooperate with the osmotic salt in providing a predetermined drug release profile. The osmotic salt need not be coated and it is in admixture with the amantadine salt. The osmotic device further includes a drug-containing coat external to the semipermeable membrane. The osmotic device can include one or more additional drugs in the core and/or the drug-containing coat.
US08574624B2 Highly inhibited starch fillers for films and capsules
The invention provides the addition of highly inhibited starch filler to gelatin-free films and soft capsules. The addition of the highly inhibited starch filler raises the solid levels during processing without substantially increasing the melt viscosity. The resultant films and capsules are transparent.
US08574615B2 Medical devices having nanoporous coatings for controlled therapeutic agent delivery
According to an aspect of the present invention, implantable or insertable medical devices are provided which contain (a) one or more depressions that contain at least one therapeutic agent, and (b) a nanoporous coating, disposed over the therapeutic-agent-containing depressions, which regulate transport of species between the therapeutic-agent-containing depressions and the exterior of the device. The implantable or insertable devices are configured to preform a role beyond mere drug delivery, for example, providing mechanical and/or electrical functions within the body, among other functions. An advantage of the present invention is that medical devices may be provided, which release therapeutic agents in quantities far exceeding the void volume within the nanoporous coating, while at the same time providing functionality that extends beyond drug delivery. Such release may further approach or achieve a zero order kinetic drug release profile.
US08574614B2 Surgical grafts for repairing chondral defects
An implant containing a collagen matrix embedded with chondrocyte-like cells, its use in repairing a chondral defect, and a method of preparing the implant.
US08574612B2 Medical devices having a coating of biologic macromolecules
A medical device having a coating of biologic macromolecules. The coating of biologic macromolecules is protected by a temporary protective layer disposed over the biologic macromolecules. The temporary protective layer serves to protect the structure (e.g., conformation) and/or function (e.g., target binding capacity) of the biologic macromolecules during processing, storage, handling, and/or delivery (e.g., implantation or insertion into a patient) of the medical device. Upon implantation or insertion into a patient's body, the temporary protective layer may dissolve to expose the biologic macromolecules to the physiologic environment.
US08574610B2 Material having antimicrobial activity when wet
An article or material is applied to the environment of the body of an animal (including humans) to provide both absorbency and antimicrobial activity. The article or material may comprise a water absorbent material; and a composition that reacts with water to produce molecular iodine. The composition provides a local concentration (in the water) of at least 10 parts per million iodine in water carried by the material (that is actual water supported by the water absorbent material) when the material has 5% by weight of water present in the water absorbent. The material may be a flowable material, or the article may be diaper, sanitary pad, bandage, adhesive pad or wrap for an animal.
US08574609B2 Disinfecting and antimicrobial compositions
Broad spectrum disinfecting and microbicidal compositions of biodegradable and environmentally friendly compositions containing esters formed from fatty organic alcohols and fatty carboxylic acids. These compositions display activities against the most resistant microbial forms including bacterial spores. The preparations can be used in health care, food processing, personal care and other industries where the use of harsh oxidizing chemicals is undesirable.
US08574606B2 Liquid agrochemical composition containing hydrophobic agrochemical active compound
There is provided a liquid agrochemical composition having a stable water-diluted state, which comprises 0.5 to 30% by weight of one or more hydrophobic agrochemical active compounds, 1 to 20% by weight of one or more nonionic surfactants selected from the group consisting of a polyoxyethylene polyoxypropylene block copolymer and the like, 0 to 10% by weight of one or more anionic surfactant, 6 to 60% by weight of γ-butyrolactone, and 20 to 75% by weight of 1,3-dimethyl-2-imidazolidinone; and water-diluted solution obtained by diluting the liquid agrochemical composition with a 10 to 10,000-fold amount of water.
US08574604B2 Methods and compositions for the delivery of biologically active agents
The invention features polymers noncovalently complexed with a biologically active agent. The polymer complexes include at least one shielding moiety covalently tethered to at least one complexing moiety, which is complexed with at least one biologically active agent.
US08574601B2 Sustained-release polymer micelle disruptable by HDL
A pharmaceutical composition containing a drug encapsulated in a polymer micelle composition containing a first block copolymer having affinity with HDL and a second block copolymer having affinity with a lipoprotein excluding HDL, each block copolymer having a hydrophobic polymer chain segment and a hydrophilic polymer chain segment such that a plurality of block copolymers arrange radially with the hydrophobic segments directed inward and the hydrophilic segments directed outward. In the composition, a detachment of the first block copolymer is induced by HDL adhesion which forms a gap and promotes the release of a drug encapsulated, while the second block copolymer excluding an affinity with HDL controls a release speed of the drug encapsulated.
US08574600B2 Porous particles and cosmetics
The invention provides porous particles, a process for producing the porous particles, and cosmetics comprising the porous particles. The porous particles of the invention have an average particle diameter of 75 μm or less, based on polyethylene resin having a crystallization degree of 70% or more. The porous particles further comprise an active ingredient. The process for producing the porous particles, comprises mixing polyethylene resin having a crystallization degree of 70% or more, and a low-molecular weight compound having a melting point lower than the softening temperature (or melting point) of the polyethylene resin, with each other at a temperature not lower than the softening temperature (or melting point) of the polyethylene resin, then spraying the mixture into a gaseous phase or a solvent at a temperature at which the viscosity of the mixture becomes 600 mPa·s or less, and removing the low-molecular weight compound from the resulting particles.
US08574596B2 Pertussis antigens and use thereof in vaccination
The invention provides BASB232 polypeptides and polynucleotides encoding BASB232 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. The invention further provides immunogenic compositions comprising a plurality of antigens selected from at least two different categories of antigen, having different functions within Bordetella. Examples of such categories of antigen are autotransporter proteins, iron acquisition proteins, lipoproteins, adhesins and toxins/invasins.
US08574590B2 Lipoparticles comprising proteins, methods of making, and using the same
The present invention relates to lipoparticles. The invention also relates to producing lipoparticles. The invention further relates to lipoparticles comprising a viral structural protein. The invention further relates to a lipoparticle comprising a membrane protein, and the lipoparticle can be attached to a sensor surface. The invention further relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
US08574589B2 Antigen purification process for pertactin antigen
Bordetella pertussis p69 antigen is purified by immobilized metal affinity chromatography.
US08574588B2 Fusion proteins comprising flagellin and dengue viral envelope proteins
Fusion proteins comprise at least a portion of at least one flagellin and at least a portion of at least one Dengue viral envelope protein. The fusion proteins are used to stimulate an immune response and protective immunity in a subject.
US08574586B2 KDR peptides and vaccines comprising the same
The present invention provides nonapeptides selected from peptides comprising the amino acid sequence of SEQ ID NO:2, 3, 5, 8, 11, or 12; nonapeptides or decapeptides selected from peptides comprising the amino acid sequence of SEQ ID NO:29, 30, 33, 34, 40, or 46; and peptides with cytotoxic T cell inducibility, in which one, two, or several amino acids are substituted or added to the above-mentioned amino acid sequences, as well as pharmaceuticals for treating or preventing tumors, where the pharmaceuticals comprise these peptides. The peptides of this invention can be used as vaccines.
US08574584B2 EphA2 T cell epitopes and uses therefor
EphA2 T-cell epitope are provided herein. The epitopes include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell epitopes, and conservative derivatives thereof. The EphA2 T-cell epitopes are useful in an assay, such as an ELISPOT assay, that may be used to determine and/or quantify a patient's immune responsiveness to EphA2. The epitopes also are useful in methods of modulating a patient's immune reactivity to EphA2, which has substantial utility as a treatment for cancers that overexpress EphA2, such as renal cell carcinoma (RCC). The EphA2 epitopes also can be used to vaccinate a patient against EphA2, by in vivo or ex vivo methods.
US08574582B2 Methods for mediating fibrotic response
Methods for mediating fibrotic response by modulating IL-25 signaling in fibrocytes are disclosed.
US08574581B2 Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus H5-subtype or N1-subtype and uses thereof
Monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes or neuraminidase glycoprotein of N1 subtypes of avian influenza virus (AIV) are provided. The monoclonal antibodies and related binding proteins are useful for the detection of H5 and N1 subtypes of AIV, including H5N1 subtypes and provide means for the diagnosis, surveillance and treatment of dangerous viral infections.
US08574578B2 Antibodies against PDGFRα to inhibit tumor growth
The invention provides antibodies that bind to human PDGFRα and neutralize activation of the receptor. The invention further provides methods for neutralizing activation of PDGFRα and methods of treating a mammal with a neoplastic disease using the antibodies alone or in combination with other agents.
US08574577B2 VEGF antibodies comprising modular recognition domains
Antibodies containing one or more modular recognition domains (MRDs) that can be used to target the antibodies to specific sites are described. The use of antibodies containing one or more modular recognition domains to treat disease, and methods of making antibodies containing one or more modular recognition domains are also described.
US08574574B2 Pharmaceutical composition comprising antibody composition which specifically binds to CCR4
A pharmaceutical composition, comprising an antibody composition which specifically binds to human CC chemokine receptor 4 (hereinafter also referred to as CCR4) and at least one medicament; and a pharmaceutical composition for administering in combination of a recombinant antibody against CCR4 and at least one medicament are required. The present invention can provide a pharmaceutical composition comprising a recombinant antibody against CCR4 and at least one medicament; and a pharmaceutical composition for administering in combination of a recombinant antibody against CCR4 and at least one medicament.
US08574570B2 Bi-stable quantum wire array of self-assembled nanomedicine and the preparation method therefor
A bi-stable quantum wire array of self-assembled nano-medicine and its process present in the invention. The bi-stable quantum wire array with quantum bit and kondo effect is prepared by self-assembling an oxygen radical antagonist of antioxidase, a β-receptor agonist, a P2 receptor agonist, a calcium antagonist of phenyl alkyl amines, and/or a nucleotide monomer of purines and its binary, ternary, quaternary or quinary compounds and using the interaction of inelastic electron tunneling. The invention not only benefits mechanisms-targeted multifunctional device discoveries, but also profits inventions of nanometer structures, novel materials, quantum calculation devices, biosensors and quantum bit magnetic random access memories (MRAM).
US08574568B2 Reduced coenzyme Q10-containing composition comprising a surfactant which is stable against oxidation and method for stabilization by mixing with surfactant(s)
The present invention provides a method for stabilization of reduced coenzyme Q10 characterized by concurrently containing a propylene glycol fatty acid ester in a composition containing reduced coenzyme Q10, and a composition containing reduced coenzyme Q10 and a propylene glycol fatty acid ester as essential constituting ingredients. According to the present invention, reduced coenzyme Q10, which is useful as a food, food with nutrient function claims, food for specified health use, nutritional supplement, nutritional product, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like can be stabilized especially without being made into a complicated composition.
US08574565B2 Pharmaceutical composition to protect an animal against a disorder arising from an infection with a bacterium that belongs to the group of nocardioform actinomycetes
The invention pertains to a pharmaceutical composition to protect an animal against a disorder arising from an infection with a bacterium that belongs to the group of nocardioform actinomycetes having the ability to survive within macrophages of the animal, comprising live bacteria of a nocardioform actinomycetes species, the live bacteria being attenuated by inactivation of a gene that encodes a protein involved in methylhexahydroindanedione propionate degradation, and a pharmaceutically acceptable carrier for these live bacteria.
US08574558B2 UV-curable nail coating formulations based on renewable polyols
A photopolymerizable composition for forming a cosmetic coating for natural and artificial nails of humans and animals comprising a photoinitiator and a (meth)acrylate monomer prepared by reacting a core polyol derived or functionalized from a renewable resource with an a (meth)acrylate monomer and coatings formed from such compositions under UV or other radiation.
US08574555B2 Stable one-part aqueous tooth whitening composition
The invention relates to a high-temperature stable, one-part, aqueous tooth bleaching composition for contacting a tooth surface. The composition comprises a bleaching agent comprising a high level of a aqueous hydrogen peroxide. The bleaching agent is derived from multiple components within the composition and comprises at least about 15% by weight of the total composition weight. The Composition also comprises a bleaching agent stabilizer comprising from about 0.01% to about 1.00% by weight of the total composition weight.
US08574552B2 Solid dosage formulations of narcotic drugs having improved buccal adsorption
Disclosed is a pharmaceutical composition in the form of a tablet suitable for dissolution in the buccal cavity, said composition comprising i) an effective amount of a narcotic active ingredient, and ii) a pharmaceutically acceptable amine having a pK of about 8 or greater, wherein the molar ratio of amine:active ingredient is at least about 5:1.
US08574546B2 Substituted aryl-fluoroborates as imaging agents
Substituted aryl-boron compounds comprising at least one 18F atom, as illustrated by the formula (I), where at least one of Y1 or Y2 is 18F and A1 is a substituted aromatic ring, with G1-5 being, independently, C or N, and where the substitutents of the aromatic ring or polycyclic moiety (other than boron) comprise at least one electron-withdrawing group (EWG), providing that sigma total (σtotal) for all substituents on the aromatic ring or polycyclic moiety except B is about 0.06 or more when said at least one EWG is positioned ortho to B, or about 0.2 or more when no EWG is positioned ortho to B. The compounds include neutral (N=1) and ionic borate (N=2) embodiments. The compounds are useful as positron emission tomography (PET) imaging agents.
US08574542B2 ZSM-5, its preparation and use in ethylbenzene dealkylation
A new configuration of ZSM-5 is provided whereby the crystals have a higher average silica to alumina ratio at the edges of each crystallite than in the center as determined from a narrow slit line scan profile obtained from SEM/EDX or TEM/EDX elemental analysis. Such ZSM-5 crystals are obtained by a preparation process using L-tartaric acid. The new configuration ZSM-5 provides significantly reduced xylene losses in ethylbenzene dealkylation, especially when combined with silica as binder, and one or more hydrogenation metals selected from platinum, tin, lead, silver, copper, and nickel. Further advantages are found if used in combination with a small crystal size ZSM-5.
US08574539B2 Process for selective oxidation of hydrogen sulphide
The present invention provides a process for the selective oxidation of hydrogen sulphide in a hydrogen sulphide-containing hydrocarbon and/or hydrogen feed gas to elemental sulphur in a reaction zone containing a Claus catalyst, comprising the steps of: i) reacting in the reaction zone the hydrogen sulphide in the hydrogen sulphide-containing hydrocarbon and/or hydrogen feed gas with sulphur dioxide at a pressure in the range of from 4 to 200 bar (absolute) and a temperature in the range of from 120 and 160° C., such that the elemental sulphur formed is essentially in liquid form; ii) contacting the catalyst with a reducing atmosphere at elevated temperatures.
US08574534B2 Carbon films produced from ionic liquid carbon precursors
The invention is directed to a method for producing a film of porous carbon, the method comprising carbonizing a film of an ionic liquid, wherein the ionic liquid has the general formula (X+a)x(Y−b)y, wherein the variables a and b are, independently, non-zero integers, and the subscript variables x and y are, independently, non-zero integers, such that a·x=b·y, and at least one of X+ and Y− possesses at least one carbon-nitrogen unsaturated bond. The invention is also directed to a composition comprising a porous carbon film possessing a nitrogen content of at least 10 atom %.
US08574533B2 Material for negative electrode of non-aqueous electrolyte secondary battery, process for producing the same, negative electrode and battery
A negative electrode material for non-aqueous electrolyte secondary batteries, comprises: a carbon material having a sphericity of at least 0.8, and exhibiting an average (002) interlayer spacing d002 of 0.365-0.400 nm, a crystallite size in a c-axis direction Lc(002) of 1.0-3.0 nm, as measured by X-ray diffractometry, a hydrogen-to-carbon atomic ratio (H/C) of at most 0.1 as measured by elementary analysis, and an average particle size Dv50 of 1-20 μm. The negative electrode material is spherical and exhibits excellent performances including high output performance and durability.
US08574528B2 Methods of growing a silicon carbide epitaxial layer on a substrate to increase and control carrier lifetime
A method of growing an epitaxial layer on a substrate is generally provided. According to the method, the substrate is heated in a chemical vapor deposition chamber to a growth temperature in the presence of a carbon source gas, then the epitaxial layer is grown on the substrate at the growth temperature, and finally the substrate is cooled in a chemical vapor deposition chamber to at least about 80% of the growth temperature in the presence of a carbon source gas. Substrates formed from this method can have a carrier lifetime between about 0.25 μs and about 9.9 μs.
US08574526B2 Cyclic preparation method for producing titanium boride from intermediate feedstock sodium-based titanium-boron-fluorine salt mixture and producing sodium cryolite as byproduct
A cyclic preparation method for producing titanium boride from intermediate feedstock sodium-based titanium-boron-fluorine salt mixture and producing sodium cryolite as byproduct, which comprises the steps: a) boric acid or boric anhydride is added with hydrofluoric acid and then with sodium carbonate solution for concentration and crystallization to generate sodium fluoborate; titanium-iron concentrate is added with hydrofluoric acid and then with sodium carbonate and sodium hydroxide to obtain sodium fluotitanate; B) the sodium fluoborate is mixed with the sodium fluotitanate, and the mixture reacts with aluminum to generate titanium boride and sodium cryolite; C) the sodium cryolite is sucked out and then fed into a rotary reaction kettle together with concentrated sulfuric acid, hydrogen fluoride gas as well as sodium sulfate and sodium aluminum sulfate are generated by reaction in the rotary reaction kettle, and the hydrogen fluoride gas is collected and then dissolved in water to obtain hydrofluoric acid aqueous solution; and D) the obtained hydrofluoric acid aqueous solution is recycled.
US08574516B2 Apparatus for insulated isothermal polymerase chain reaction
An apparatus for holding a test tube in which insulated isothermal polymerase chain reaction is performed includes a heat sink and a tube rack. The heat sink has a main body with a through hole for insertion of the test tube. The through hole has a relatively big diameter section and a relatively small diameter section located below the relatively big diameter section. The tube rack is mounted on the heat sink for insertion of the test tube. The apparatus can ensure that the temperature at the liquid level of the reaction mixture is lower than the temperature suitable for conducting the primer annealing step in the polymerase chain reaction process.
US08574515B2 Magnetic separating device
The disclosure relates to a magnetic separating device for isolating magnetically labelled particles from a non-magnetic medium comprising a body portion (1) having a magnetising portion (3) for providing a magnetic field and a surface by means of which the body portion may stand on a supporting surface; and a sample vessel retaining portion (4) for retaining at least one sample vessel (5), wherein, the magnetising portion (3) is configured to conform at least approximately to at least a substantial portion of the longitudinal profile of at least one sample vessel (5); the sample vessel retaining portion (4) is configured to retain at least one sample vessel (5) such that at least a portion of the contents of the sample vessel (5) is visible to a user; and the sample vessel retaining portion (4) is configured to be mountable on the magnetising portion so that in use, the at least one sample vessel is subject to the magnetic field of the magnetising portion (3). The disclosure further relates to a kit of parts and a method for isolating magnetically labelled particles from a non-magnetic medium using the magnetic separation device.
US08574513B2 Single-layer PCB microfluidics
A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal traces on a surface of the printed circuit board structure prior to encapsulation. The metal traces are removed by etching after encapsulation to form microchannels within the encapsulant.
US08574512B2 Laboratory device unit having a laboratory device and a remote control
A laboratory device unit (1) for processing or analyzing substances, mixtures or media, is provided having functional elements provided in or on a laboratory device (3) for carrying out said processing and/or analyzing. At least two remote controls (2, 6) are provided, wherein a range of functions of the functional elements can be used to a lesser extent with the one remote control (6) than with the other remote control (2).
US08574509B2 Sensor holder, holder unit in which blood sensor is mounted to the sensor holder, and blood testing device to which the holder unit is mounted
A sensor holder comprises a sensor mounting part having a first face on which a blood sensor is placed, a second face provided on the opposite side from the first face, and a through-hole that goes from the first face to the second face and is large enough to allow a laser beam to pass through; a finger holding part that is provided on the second face and surrounds the through-hole, and a grip that sticks out from the blood testing device when the sensor holder is mounted to the blood testing device.
US08574507B2 Heat exchanger-integrated reaction device having supplying and return ducts for reaction section
A compact heat exchanger-integrated reaction device, comprising a heat exchange section and a reaction section, capable of providing high heat recovery performance, with a small number of ducts of the reaction section formed for supplying and return paths without increasing the volume of the entire reaction device. With the heat exchanger-integrated reaction device equipped with ducts in the reaction section adjacent to the plate-stacking-type heat exchange section, collection ducts for allowing a plurality of regions having openings for discharging a fluid to be processed to be connected with at least one supplying duct of the reaction section, and distribution ducts for allowing at least one supplying duct of the reaction section to be connected with a plurality of regions having openings for receiving the fluid from the heat exchange section are provided between the heat exchange section and the duct of the reaction section.
US08574504B2 Plasma scrubber
A plasma scrubber that forms a high temperature atmosphere in a reactor to effectively decompose and remove a non-biodegradable gas and reduce power consumption is disclosed. The plasma scrubber includes: a first reactor to which a non-biodegradable gas is supplied; an electrode installed in the first reactor and protruding in the flow direction of the non-biodegradable gas to generate plasma in the non-biodegradable gas supplied between the electrode and the first reactor by a discharge reaction in the first reactor; a second reactor connected to the first reactor to form continuous arc jets by anchoring the plasma to the electrode; and a third reactor connected to the second reactor to decompose the non-biodegradable gas by forming a reaction section of high temperature that contains electrons and chemical species of high reactivity in the second reactor and thereby increasing the stay time and reactivity of the non-biodegradable gas.
US08574497B2 Separator and separation strip
A separator (1a) under the invention for the taking of blood serum or blood plasma contained in a blood sample from a separating strip comprises a top part (3), a bottom part (4) and a joint (5). Said top part (3) and bottom part (4) are linked by the joint (5) in a pivoting way. Bottom part (4) is designed to support the separating strip. At least one nose (7a, 7b) is provided at the bottom part (4) and/or underside of top part (3) which can exert local pressure on the separating strip once top part (3) and bottom part (4) are folded together thus pressing blood serum or blood plasma out of the rear end of the separating strip.
US08574494B2 In situ heat induced antigen recovery and staining method
An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.
US08574492B2 Sterilization-cleaning device and sterilization-cleaning method for cap
Provided is a chute-type cap sterilization-cleaning device which transfers caps and performs sterilization-cleaning by injecting sterilization-cleaning liquid from a propulsion nozzle, wherein a controller (11) and a solenoid valve for controlling a plurality of reverse propulsion nozzles (2e) are provided, and wherein when sterilization and cleaning of a cap (C) is continued at a chute portion for sterilization-cleaning while cap transfer is stopped by a dividing device, in order to relax the accumulated pressure on the cap (C) at the downstream side, the reverse propulsion nozzles (2e) performing straight injection of the sterilization-cleaning liquid toward the reverse side with respect to the transfer direction of the cap (C) are arranged along the chute portion for sterilization-cleaning so that the injected flows are in contact with the inner surfaces of several caps (C).
US08574489B2 Compaction methods
The present invention is directed to improved compaction techniques for use in powder metallurgical applications using lower temperatures and pressures than are traditionally used in the field.
US08574487B2 Workpiece processing using a beam
A cutting machine includes a suction duct that is movable with a cutting head of the cutting machine, using a common drive. The suction duct is disposed beneath the workpiece support and coupled to the motion unit supporting the cutting head so that it moves with the motion unit while an opening of the suction duct remains positioned below the cutting head during a cutting operation. The suction duct removes cutting debris and dust, and protects underlying machine components from beam damage.
US08574482B2 Cold casting method and apparatus
Method of cold casting a composite product which includes the steps of making a composite mixture comprising a curable resin and metal particles, pouring the composite mixture into a mold made of a machinable and recyclable substrate; and curing the composite mixture in a pressurized chamber for a time sufficient to eliminate the appearance of bubbles in the cured composite mixture. The curable resin is selected to have a cure time and a viscosity that allows the metal particles to fall to the bottom of the mold to appear on the face of the composite product. The finished product can resemble traditional foundry cast metal products while employing a much lower amount of metal to achieve cost savings.
US08574480B2 Partial die process for uniform etch loading of imprint wafers
Methods, systems, and devices which result from, or facilitates, convenient processing of partial dies of a semiconductor chip in a lithography process are disclosed. Embodiments utilize an exposure through an imprint-style template which does not come in physical contact with the partial die. In one embodiment, a semiconductor process is disclosed which has at least one full die and at least one partial die. The semiconductor chip is fabricated, in part, by using an etching process which utilizes an imprint template configured to be exposed to the at least one full die when the imprint template is in contact with resist which has been dispensed onto the at least one full die. Further, at least one partial die of the semiconductor chip is configured to be exposed to the imprint template without the template contacting resist dispensed onto the at least one partial die.
US08574478B2 Slip additive composition in thermoplastic polymer processing
The present invention relates to the use of a fatty acid ester as a slip additive in the production of molded polyethylene terephthalate articles, to a thermoplastic molding composition comprising a polyethylene terephthalate and a fatty acid ester selected to be effective for reducing the co-efficient of friction of molded articles formed from the composition, to a molded polyethylene terephthalate article comprising a fatty acid ester selected to be effective in reducing the co-efficient of friction of the molded article, and to a process for producing a molded thermoplastic article comprising providing a thermoplastic molding composition comprising polyethylene terephthalate, admixing with the thermoplastic molding composition at least one fatty acid ester selected to be effective in reducing the co-efficient of friction of the molded article, heating the composition and molding the hot composition so as to form a molded article.
US08574470B2 Combustion synthesis to bond metal inserts to C-C composite surfaces
Method of joining a carbon-carbon composite piece 30 together with a metal insert 20, e.g. in the manufacture of aircraft brake discs 10. The method includes the steps of: providing a carbon-carbon composite piece 30 and a metal insert 20, wherein the metal insert 20 has a surface that is complementary to a surface of said carbon-carbon composite piece 30; providing a layer of a mixture of titanium powder and carbon powder on the first complementary mating surface; arranging the powder layer such that a second complementary mating surface is matched to the complementary mating surface, thereby forming a construct of the carbon-carbon composite piece 30, the powder layer, and the metal insert 20; placing the construct into a press and applying pressure to the construct to press together the carbon-carbon composite piece and the metal insert joined at their complementary surfaces; and applying an electrical current to the powder in the construct to initiate a metal-carbon reaction, thereby bonding the carbon-carbon composite piece 30 together the metal insert 20. The titanium powder particles may be from 25 to 100 microns in diameter, and the carbon powder (e.g., graphite particles) may be 0.1 to 1 microns in diameter.
US08574468B1 Benzo-fused heterocyclic chromophores for nonlinear optical devices
A benzo-fused-heterocyclic elongated dye having a superior molecular hyperpolarizability and yet having an acceptably-low optical absorbance of light near 1550 nm in wavelength, which is an important optical communication band for telecommunication applications.
US08574466B2 Modified polyamine
A pigment dispersant which includes a modified polyamine obtained by the reaction of a polyamine having two or more primary and/or secondary amino groups per molecule and containing 2 to 1800 nitrogen atoms per molecule, a polyester, and a phosphorus-containing compound. The modified polyamine exhibits excellent pigment dispersion performance, shows little change in color tone upon heating, and has excellent heat resistance.
US08574461B2 Electroactive biopolymer optical and electro-optical devices and method of manufacturing the same
A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and enzymatically polymerizing an organic compound to generate a conducting polymer between the provided polymer and the substrate. The polymer may be a biopolymer such as silk and may be modified using organic compounds such as tyrosines to provide a molecular-level interface between the provided bulk biopolymer of the biopolymer optical device and a substrate or other conducting layer via a tyrosine-enzyme polymerization. The enzymatically polymerizing may include catalyzing the organic compound with peroxidase enzyme reactions. The result is a carbon-carbon conjugated backbone that provides polymeric “wires” for use in polymer and biopolymer optical devices. An all organic biopolymer electroactive material is thereby provided that provides optical functions and features.
US08574460B2 Processing of biomass-derived oxygenates with particles comprising a coke deposit
A method is disclosed for producing a mixture of CO and H2 (syn-gas). The method comprises contacting particles containing a coke deposit with oxygenated molecules derived from biomass. In a preferred embodiment the particles are catalyst particles.The method may be carried out in the regenerator of a conventional fluid catalyst cracking (FCC) unit.
US08574456B2 Liquid-crystalline medium and liquid crystal display
The invention relates to a liquid-crystalline medium comprising one or more compounds of the formula I in which R0, X0 and L1-6 have the meanings indicated in Claim 1, and to the use thereof in electro-optical liquid-crystal displays.
US08574454B2 Patternable liquid crystal polymer comprising thio-ether units
The present invention relates to a photo-polymerized, patterned or unpatterned liquid crystal polymer, especially a liquid crystal polymer film or a liquid crystal polymer network, comprising thio-ether units of formula (I) * covalent bond, which links the unit of formula (I) to the residue of the polymer wherein LC1 is selected from the group of liquid crystal residues, X1 is selected from the group of aliphatic organic residues, and n1 is an integer ≧0 and m1 is an integer ≧0; with the proviso that if n1 is 0, then m1 is >0, and if m1 is 0, then n1>0; which is prepared in an atmosphere containing oxygen, preferably with an amount of 0.1≦oxygen≦50%, more preferably 1≦oxygen≦25%, most preferably in air; with the proviso that polymer dispersed liquid crystals are excluded. Further, this invention relates to a composition used for the preparation of that photo-polymerized liquid crystal polymer of the invention, to processes of the preparation of that liquid crystal polymer and to its use.
US08574452B2 Heat dissipation composition
A heat dissipation composition includes a hydroxy function group contained double-bond substance (such as 2-hydroxybenzophenone, 2-hydroxydibenzoacid, and alkyl 2-cyano-3,3-diphenylacrylate) formed of aromatic hydrocarbons having precursor of benzene, which is mixed with a resin-based coating agent and a diluting agent at predetermined ratios for application on a surface of a heat dissipater to facilitate heat dissipation, whereby when the heat dissipater receives heat to be dissipated, the double-bond substance absorbs the heat and induces displacement to form a resonance structure so as to more efficiently dissipate the heat and when the heat is dissipated, the substance restores the double-bond condition thereby realizing improvement of efficiency of heat dissipation.
US08574446B2 Apparatus and method for plasma processing
At the time of plasma igniting or during plasma processing, only optimizing the distance between electrodes in each case caused a limitation to the prevention of charging damage. To resolve this, a novel plasma processing method employs a plasma processing apparatus which includes an upper electrode to which first high-frequency power is applied, a lower electrode to which second high-frequency power is applied, and a lift mechanism for controlling the spacing between the upper and lower electrodes. The first high-frequency power is applied to the upper electrode to cause plasma igniting. The method is adapted to make the spacing between the upper and lower electrodes larger at least at the time of plasma extinction than during plasma processing of a wafer on the lower electrode.
US08574445B2 Method for generating hollow cathode plasma and method for treating large area substrate using hollow cathode plasma
Provided are a method for generating hollow cathode plasma and a method for treating a large area substrate using the hollow cathode plasma. In the methods, the hollow cathode plasma is generated by a gas introduced between a hollow cathode in which a plurality of lower grooves where plasma is generated is defined in a bottom surface thereof and a baffle in which a plurality of injection holes is defined. A substrate disposed on a substrate support member is treated using the hollow cathode plasma passing through the injection holes. The uniform plasma having high density can be generated by hollow cathode effect due to the hollow cathode having the lower grooves and the injection holes of the baffle. Also, since the substrate can be treated using a hydrogen gas and a nitrogen gas in an ashing process, a damage of a low dielectric constant dielectric can be minimized.
US08574442B2 Method for wet oxidation of effluents heated essentially by self-combustibility, and corresponding installation
A method for treating effluent containing dissolved or suspended solids includes directing the effluent containing dissolved or suspended solids to a reactor and oxidizing at least a portion of the dissolved or suspended solids in the reactor with an oxidizing agent. Oxidation is carried out at a temperature ranging between approximately 20° C. and approximately 350° C. and at a pressure ranging between approximately 1 bar and approximately 160 bar. A gaseous phase and a liquid phase form within the reactor during oxidation. The method includes separating the gaseous phase from the liquid phase and heating the effluent in the reactor with the heat produced from the oxidation of the dissolved or suspended solids.
US08574441B2 Process for removing oxidants from water injected into a subsurface aquifer to prevent mobilization of trace metals
A method for providing for the use of underground aquifers for water storage for municipalities or recharge. Water is treated and injected for storage in the aquifer by the addition of a small amount of a sulfide compound to remove dissolved oxygen and prevent dissolution of negative valence sulfur bearing minerals, such as pyrite, in the subsurface. The stored water may be subsequently withdrawn from the aquifer and treated to remove residual amounts of sulfide ions. The withdrawn water being suitable as potable water, irrigation water, industrial use water, and aquifer water level enhancement water.
US08574439B2 Valuable resource recovery system and operation method thereof
A valuable resource recovery system includes an engineered powder supply unit that supplies an engineered powder into drainage water (the engineered powder can adsorb a valuable resource and can be desorbed from the engineered powder), an agitation unit that agitates the drainage water supplied with the engineered powder, an engineered powder separation unit that separates the engineered powder from the drainage water agitated by the agitation unit, an engineered powder collection unit that collects the engineered powder separated by the engineered powder separation unit, and a desorption-recycle unit that desorbs the valuable resource from the engineered powder collected by the engineered powder collection unit to recycle the engineered powder and the valuable resource. According to the system, the valuable resource can be desorbed from the engineered powder and then recycled.
US08574438B2 Dialysate regeneration unit
A dialysate regeneration unit adapted for regenerating a dialysate containing carrier substances comprises a first flow path and a second flow path. The first flow path comprises a first supply unit adapted for adding an acidic fluid to the dialysate flowing in the first flow path, and a detoxification unit located downstream of the first supply unit. The detoxification unit is adapted for removing toxins from the acidified dialysate flowing in the first flow path. The second flow path extends in parallel to the first flow path. The second flow path comprises a second supply unit adapted for adding an alkaline fluid to the dialysate flowing in the second flow path, and a further detoxification unit located downstream of the second supply unit. The further detoxification unit is adapted for removing toxins from the alkalised dialysate flowing in the second flow path.
US08574437B2 Method for production of chromatography media
The present invention relates to a method of producing novel chromatography media and use thereof for purification of biomolecules, such as proteins. The chromatography media comprises shell beads having an inner porous core and an outer shell. The method comprises providing buffering ligands in the core of the beads, and providing binding ligands aimed for biomolecule binding in the outer shell of the beads. This method makes it possible to optimize binding properties and buffering properties independently of each other which is especially to advantageous for production of chromatofocusing media.
US08574436B2 Displacement filter apparatus
A method and apparatus for filtering a slurry utilizing a displacement filtering principle. The filter apparatus desirably includes an inner filter and an outer filter. Both the inner and outer filters are preferably substantially annular in shape and positioned concentrically with respect to each other. A particulate collection volume is at least partially defined between the inner and outer filter. The method includes directing a flow of slurry into the particulate collection volume under sufficient pressure to force fluid within the particulate collection volume through one of the inner and outer filters and any particulate matter blocking a filtering surface of the inner and outer filters.
US08574434B2 Integrated high throughput system for the analysis of biomolecules
Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules.
US08574430B2 Filter assembly with modular relief valve interface
A fluid filter for assembly includes an upright housing having a base portion and a cover to allow viewing of a fluid level. The base portion has a fluid inlet and a fluid outlet. A filter element has a filter media for filtering the fluid, a bottom end cap connected to the fluid outlet, and a top end cap positioned above the bottom end cap. A mounting member is formed on the top end cap, and a vent passage extends through the mounting member for fluid communication between an interior and an exterior of the filter element. An interface structure is connected to cover the upright housing and is removably engageable with the mounting member of the filter element.
US08574422B2 Hydrogen production
A process and apparatus are provided for producing hydrogen from a hydrocarbon fuel by combining the fuel with a gas comprising both oxygen and steam, and passing the resulting mixture through a plasma generated by a microwave plasma generator between opposed electrodes. At least one of the electrodes defines a duct for outflow of gaseous material from the vicinity of the plasma, and the gas mixture emerging from the outflow duct contains hydrogen. The fuel undergoes partial oxidation and steam reforming, the reactions being initiated by the plasma rather than by a catalyst.
US08574419B2 Chemical reactor with nanometric superstructure
The invention relates to a chemical reactor with a nanometric superstructure, comprising at least one member wherein at least one reaction chamber is arranged, and said reaction chamber being filled at least partially with a high specific surface area material having a specific surface area greater than 5 m2/g, and characterized in that said high specific surface area material is selected from nanotubes or nanofibers.These nanotubes or nanofibers are preferably selected in the group consisting of carbon nanofibers or nanotubes, β-SiC nanofibers or nanotubes, TiO2 nanofibers or nanotubes.They may be deposited on an intermediate structure selected in the group consisting of glass fibers, carbon fibers, SiC foams, carbon foams, alveolar β-SiC foams, said intermediate structure filling the reaction chamber of said reactor at least partially.
US08574416B2 Method for producing exhaust pipe
A method for producing an exhaust pipe includes electrocoating a surface of a metal base material with a paint to form a coat film. The paint includes inorganic glass particles and an electrocoating resin. The coat film is heated to a first temperature that is not lower than a burning-out temperature of the electrocoating resin. The coat film is heated, after heating the coat film to the first temperature, to a second temperature that is not lower than a softening point of the inorganic glass particles to produce the exhaust pipe which includes the metal base material and a surface coating layer formed on the surface of the metal base material.
US08574414B2 Copper prerinse for electrodepositable coating composition comprising yttrium
A method includes (a) contacting at least a portion of a substrate material with a solution comprising a source of copper, wherein the solution is essentially free of a source of a group IIIB metal and a source of a group IVB metal; and (b) after step (a), contacting at least a portion of the substrate with an electrodepositable coating composition comprising (i) a film-forming resin and (ii) a source of yttrium.
US08574408B2 Fluid recirculation system for use in vapor phase particle production system
A method of and system for recirculating a fluid in a particle production system. A reactor produces a reactive particle-gas mixture. A quench chamber mixes a conditioning fluid with the reactive particle-gas mixture, producing a cooled particle-gas mixture that comprises a plurality of precursor material particles and an output fluid. A filter element filters the output fluid, producing a filtered output. A temperature control module controls the temperature of the filtered output, producing a temperature-controlled, filtered output. A content ratio control module modulates the content of the temperature-controlled, filtered output, thereby producing a content-controlled, temperature-controlled, filtered output. A channeling element supplies the content-controlled, temperature-controlled, filtered output to the quench chamber, wherein the content-controlled, filtered output is provided to the quench chamber as the conditioning fluid to be used in cooling the reactive particle-gas mixture.
US08574407B2 Plasmonic structures for mediating chemical transformation
The present invention relates to plasmonic structures of metal dielectrics and their use in corresponding processes that elicit surface plasmons which may then be employed to influence a chemical transformation. The frequency of a plasmon may be tuned to couple with a selected vibrational mode of a selected molecule to undergo a selected transition, such as transitions to a metastable state, bond rearrangement and/or chemical transformation via the breaking and reforming of bonds.
US08574404B1 Fast pyrolysis processor which produces low oxygen content, liquid bio-oil
In this fast pyrolysis processor the reaction conditions are tailored to minimize the production of gas, while using calcined limestone to provide the heat for fast pyrolysis of biomass and to lower the acidity and oxygen content of the liquid bio-oil which is produced.
US08574403B2 Fabric belt for a machine for producing web material, in particular paper or cardboard
A fabric belt for producing a web material, the fabric belt including a first layer on a web material side and a second layer on a machine side of the belt. The layers each having a basic weave connected to each other by binding threads extending in a binding thread direction. The layers having base binding threads extending both in and transverse to the binding thread direction. The binding threads form binding segments which are successive in the binding thread direction in the second layer. The binding threads are tied off on one base binding thread of the second layer extending transversely to the binding thread direction. The binding segments formed in the second layer are arranged in a binding pattern repeat extended in and transverse to the binding thread direction along a binding segment diagonal progressing obliquely to the binding thread direction and transverse to the binding thread direction.
US08574402B2 Feeding system having pumps in parallel for a continuous digester
The feed system is for a continuous digester where at least two pumps are arranged in parallel at the bottom of a pre-treatment vessel. The outlets of the pumps are combined at a merging point before a common transfer line extends to the top of the digester. The system makes it possible to provide a feed system with an improved accessibility and operational reliability, and to operate the main part of the pumps at optimal efficiency even if the production capacity is reduced.
US08574398B2 Apparatus and method for detaping an adhesive layer from the surface of ultra thin wafers
An apparatus for removing an adhesive layer from a wafer surface includes a chuck, a contact roller, a pick-up roller and a detaping tape. The chuck supports and holds a wafer that has an adhesive layer on its top surface. The contact roller rotates around a first axis and moves linearly along a direction perpendicular to the first axis over the chuck and the supported wafer. The pick-up roller rotates around a second axis, that is parallel to the first axis. The detaping tape rolls around the contact roller and the pick-up roller, and as it rolls it attaches to the adhesive layer, and then is removed together with the adhesive layer. The contact roller has a surface that has a footprint of a circle when rolled along a flat surface.
US08574392B2 Method for anticorrosive treatment of metal surfaces
A method for anticorrosive treatment of metal surfaces, especially at edges and transitions of the metal components, characterized in that a self-adhesive tape is applied to the metal surface and the self-adhesive tape contains at least one layer with a material which is heated such that the material melts onto the metal surface and thus forms an anticorrosive layer.
US08574391B2 Method for joining a profiled first structural component to a second structural component
The invention relates to a method for joining precured stringers to at least one structural component of an aircraft or spacecraft. A vacuum arrangement required for the joining is produced in two parts. In a first step, each precured stringer is covered in advance by a covering vacuum film. The stringers prepared in this manner are arranged on the structural component. Vacuum film strips are subsequently arranged in each case on adjacent stringers and over an intermediate space between the adjacent stringers. With the use of a vacuum sealing means, the vacuum film strips and the covering vacuum films 8 form a continuous vacuum arrangement. The stringers are subsequently joined under pressurization to the structural component with the use of this vacuum arrangement.
US08574386B2 Method for manufacturing honeycomb structure
A method for manufacturing a honeycomb structure includes molding a ceramic raw material to manufacture at least one honeycomb molded body having a plurality of cell walls extending along a longitudinal direction of the at least one honeycomb molded body to define cells. The honeycomb molded body is fired to manufacture a honeycomb fired body. A honeycomb block is manufactured by using the honeycomb fired body. The honeycomb fired body is cut before manufacturing the honeycomb block or the honeycomb block is cut after manufacturing the honeycomb block.
US08574385B2 Attaching a communication line to a target surface on or inside of a building
A communication line such as an optical fiber or cable is attached along a wall, ceiling, trim piece, or other target surface inside of a building by laying out the line from an applicator tool. An outer surface of the line is placed in a temporarily tacky condition as the line is laid out from the tool along the target surface. The temporarily tacky condition of the line is due at least in part to an adhesive component that is pre-applied to the outer surface of the line. The adhesive component is activated by an agent or medium that is associated with the applicator tool. The line becomes non-tacky after it is attached to the target surface.
US08574384B1 Tags for the sorting of plastics
Methods and systems for identifying and sorting of different plastics rely on the differences in the surface polarity of the various plastics. A marking system may be used which provides markers that adhere specifically to only one type of plastic, and the adhering markers may then allow for a positive identification of the plastic. This type of system may be used for the identification and separation of polylactic acid plastics from various other plastics.
US08574383B2 Method and apparatus for determining blowout in a corrugation
A corrugator includes a separation sensor for sensing separation of a corrugated medium and liner of a corrugated paperboard. Sensing the separation, also known as blowout or fluff out, allows the corrugator to be controlled to prevent problems which arise when corrugated paperboard having such a separation continues downstream along the corrugator. Typically, the corrugator is operated to cease downstream movement of the paperboard while a faulty segment which includes the separation is removed and the problem causing the separation is fixed, thereby providing for subsequent production of corrugated paperboard which is properly glued.
US08574382B2 Heat-resistant aluminium alloy
A cold-hardening aluminum casting alloy with good thermal stability for the production of thermally and mechanically stressed cast components, wherein the alloy includesfrom 11.0 to 12.0 wt % siliconfrom 0.7 to 2.0 wt % magnesiumfrom 0.1 to 1 wt % manganeseless than or equal to 1 wt % ironless than or equal to 2 wt % copperless than or equal to 2 wt % nickelless than or equal to 1 wt % chromiumless than or equal to 1 wt % cobaltless than or equal to 2 wt % zincless than or equal to 0.25 wt % titanium40 ppm boronoptionally from 80 to 300 ppm strontiumand aluminium as the remainder with further elements and impurities due to production individually at most 0.05 wt %, in total at most 0.2 wt %. The alloy is suitable in particular for the production of cylinder crank cases by the die-casting method.
US08574380B2 Composite magnetic material and method of preparing the same
The present invention discloses a composite magnetic material. The composite magnetic material may comprise an Nd—Fe—B alloy and a Fe-based soft magnetic alloy having the general formula of Fe100-x-y-z-aAxRaSiyBz. A may be at least one element selected from Cu and Au. R may be at least one element selected from the group consisting of Ti, Zr, Hf, Mo, Nb, Ta, W and V. And the x, a, y, and z may satisfy: 0≦x≦3, 0≦a≦10, 0≦y≦20 and 2≦z≦25. The present invention further discloses a method of preparing the composite magnetic material as described above. According to the present invention, the composite magnetic material may have an enhanced magnetic energy product and residual magnetism respectively.
US08574379B2 Method for cutting with gas and apparatus for cutting with gas
The object of the present invention is to provide a method for cutting with gas which uses a cutting tip including a preheating hole for forming a preheating flame with a fuel gas and an oxygen gas for preheating, and an oxygen gas hole for cutting a workpiece by injecting oxygen gas for cutting, and which can decrease an amount of hydrogen gas used by supply a fuel gas to the preheating hole, which is appropriate in both heating and cutting the workpiece, and an apparatus for cutting with gas, and the present invention provides an apparatus for cutting with gas (30) which supplies an oxygen gas, and a fuel gas to a cutting tip (20) including a preheating hole (23) and an oxygen gas hole for cutting (22), wherein the apparatus (30) includes a supply circuit for oxygen gas (50), a supply circuit for hydrogen gas (41), a supply circuit for hydrocarbon-based gas (45), and a gas supply control means (60), and the gas supply control means (60) can alter a ratio of the hydrogen gas and the hydrocarbon-based gas which are supplied to the preheating hole in a case of heating the workpiece and a case of cutting the workpiece.
US08574373B2 Method of operating a dishwasher
A method of operating a dishwasher includes storing wash liquid in a portion of the spray system of the dishwasher for subsequent reuse. The spray system can include one or more supply conduits, and wash liquid can be alternatively supplied to the supply conduits to store the wash liquid in at least one of the supply conduits.
US08574372B2 Nozzle cleaning method, nozzle cleaning device, and automatic analyzer
A nozzle cleaning method includes cleaning an outer wall of a dispenser nozzle after liquid is sucked and before the liquid is discharged and cleaning at least an inner wall of the dispenser nozzle after the liquid is discharged.
US08574370B2 Use of alkane sulphonic acid for rust removal
The present invention relates to the use of at least one alkane sulphonic acid, with formula R—SO3H, where R represents a saturated, linear or branched hydrocarbon chain, comprising 1 to 4 atoms of carbon for removing rust from all types of surface, in particular from metal surfaces, specifically iron, steel and others. The invention also relates to a method for cleaning rust from all types of surfaces using at least one alkane sulphonic acid.
US08574368B2 Conversion method
A process is described for the preparation of water-soluble cellulose hydrolysis products, which comprises admixing cellulose with an ionic liquid capable of solvating or dissolving at least some of the cellulose, said ionic liquid being a compound comprised solely of cations and anions and which exists in a liquid state at a temperature at or below 150° C., the cations in said ionic liquid having the general formula (I), in which Z represents a nitrogen or phosphorus atom, R1 represents a methyl or ethyl group, each of R2 and R3, which may be the same or different, is selected from C4-3alkyl, optionally-substituted benzyl, optionally-substituted phenyl, and C5-7 cycloalkyl, and R4 represents C1-8 alkyl, optionally-substituted benzyl, optionally-substituted phenyl or C5-7cyclohexyl; in which the optional substituents on a benzyl or phenyl ring are one, two or three substituents selected from C1-4alkyl or alkoxy groups, halogen atoms and nitro groups; and treating the resulting solvate or solution with an acid in the presence of water, said acid having a pKa in water of less than 2 at 25° C.
US08574367B2 Evaporation source
In an evaporation source, a separable heater is used when an organic thin film is formed on a substrate in order to realize full-colors so that it is possible to correspond to crucibles of various capacities. The evaporation source comprises a crucible in which an organic material which is an organic thin film material is accommodated, and the crucible includes a heating unit and at least one spray nozzle for spraying the organic material onto a substrate. In the heating unit, a heater divided into at least two parts is provided on the external surface of the crucible at uniform intervals, and the heaters are separately disposed with respect to each other, but are connected to each other by connecting members. Therefore, it is not necessary to perform an additional design whenever the capacity of the crucible is changed, it is not necessary to exchange the evaporation source, and it is possible to reduce cost and to improve repairing ability.
US08574365B2 Apparatus for applying a primer coating with the aid of vacuum
Apparatus for application of primer with the aid of vacuum, includes a reservoir (26) for liquid primer, an applicator nozzle (14) having an applicator chamber (16) and a suction chamber (18), a supply system (24, 26) for supplying primer from the reservoir (28) to the applicator chamber (16), a suction system (30, 32) for withdrawing air and primer from the suction chamber (18) and a separator (34) for separating primer from the withdrawn air and recirculating the separated primer into the reservoir (28), wherein the separator (34) is a cyclone.
US08574361B2 Group-III element nitride crystal producing method and group-III element nitride crystal
A method for producing a high-quality group-III element nitride crystal at a high crystal growth rate, and a group-III element nitride crystal are provided. The method includes the steps of placing a group-III element, an alkali metal, and a seed crystal of group-III element nitride in a crystal growth vessel, pressurizing and heating the crystal growth vessel in an atmosphere of nitrogen-containing gas, and causing the group-III element and nitrogen to react with each other in a melt of the group-III element, the alkali metal and the nitrogen so that a group-III element nitride crystal is grown using the seed crystal as a nucleus. A hydrocarbon having a boiling point higher than the melting point of the alkali metal is added before the pressurization and heating of the crystal growth vessel.
US08574358B2 Geopolymeric particles, fibers, shaped articles and methods of manufacture
Shaped geopolymeric particles, fibers, and articles incorporating at least one geopolymer are provided; the geopolymeric particles, fibers, and articles having a structure that is solid, foamed, hollow or with one or more voids. Geopolymers are formed by alkali activation of an aluminosilicate and/or aluminophosphate material. The end-products are shaped as spheres, flakes, fibers, aggregates thereof or articles. Such products are formed at low temperatures; wherein forming includes processing using techniques such as spray drying, melt spinning, or blowing. The shaped geopolymeric particles and fibers have high chemical durability, high mechanical strength, application-targeted flowability and packing properties, and are specially suited for incorporating into composite materials, articles, and for use in cementitious, polymeric, paint, printing, adhesion and coating applications. Shaped geopolymeric particles, fibers and articles having voids, hollow or foam-like structures are formed by adding one or more blowing agents.
US08574355B2 System for checking filter of air cleaner for automobiles
A system recognizes a check-up time of a filter of an air cleaner. The system includes a power unit that supplies power to the system, a pressure sensor that measure pressure of a filter, at an outlet connected with a filter unit, a conversion circuit that converts the measured value into a predetermined type, a processor that controls the measurement period of the pressure sensor and receives and compare the measured value converted by the conversion circuit with a predetermined reference value, and a display unit that displays a filter replacement period.
US08574351B2 Apparatus and method for gas liquid separation in oil and gas drilling operations
A two phase gas-liquid separation apparatus is provided that shapes the flow in a flow shaping line. Shaping the two-phase flow allows centrifugal force to send the heavier, denser liquid to the outside wall of the flow shaping line and allows the lighter, less dense vapor or gas to occupy the inner wall of the flow shaping line. With the gas positioned on the inner wall of the flow shaping line, an exit port on the inner wall will allow for the majority, if not all, of the gas, along with a low amount of liquid, to be sent to a conventional separator. A high ratio of vapor/liquid at a flow rate much lower than the total flow rate within the flow shaping line is sent to the conventional separator. This allows for efficient separation of the vapor from the liquid with the use of a smaller conventional separator.
US08574350B2 Water separation systems and methods
A water separation system and method for treating multiphase hydrocarbon production streams is disclosed. The system may be employed to separate gas from the production stream, and then separate the liquid stream into its oil component and water component. A gas/liquid separator may be employed to separate a multiphase hydrocarbon production stream into a gas stream and a liquid stream. A liquid cyclone separator, positioned downstream from the gas/liquid separator, may be employed to divide the liquid stream into an oil dominated portion and a water dominated portion. The system may be used on land or on offshore platforms in locations where it is desirable to separate oil and water from hydrocarbon streams.
US08574348B2 Process for purifying a gas in a temperature swing adsorption unit
A temperature swing adsorption process to purify a gas comprising at least one adsorption step and at least one regeneration step wherein the regeneration step takes place at a lower pressure than the adsorption step. The pressure is increased by a repressurization step between the regeneration step and the adsorption step, and then a purge step takes place after said repressurization step.
US08574346B2 PSA method using a composite adsorption bed comprising an adsorbent and PCM agglomerates
A thermocyclic process having a short cycle time, typically a cycle time of less 30 minutes, especially a PSA (Pressure Swing Adsorption) process, using agglomerates that contain phase change materials (PCMs), so as to reduce the thermal effects that said thermocyclic process is subjected to during each cycle is provide.
US08574343B2 Methods and systems for setting an air filter change threshold in an HVAC system using a blocking panel
A blocking panel may be used to set an air filter change threshold value for an air filter monitor installed in an HVAC system. The air filter change threshold value may then be used to determine a status of an air filter (e.g., clean or dirty).
US08574342B1 Method and apparatus for membrane separation
Method and apparatus for a membrane separation system, including process and installation for the separation of air by permeation, using two strategically placed heaters for the production of high purity nitrogen, uniquely designed multi-staged pre-filtration system and a novel method of controlling the nitrogen flow and purity. The system comprises in series an air compressor (1), an air cooler (2) cooled by air or liquid, moisture separator (3), mist removing filter (4), primary heat source (5), coalescing filter (8), carbon tower (9), particle filter (10), secondary heat source (11), membrane separator(s) (14), and control valve (19). The system is to provide and maintain superheated air to the membrane separator(s) using strategically located heaters to eliminate condensation of moisture in the carbon tower or membrane separator(s) eliminating the need for a separate compressed air dryer, or the need for insulation of pipes, vessels and the membrane separator(s). This method allows simple process controllers to auto tune and maintain accurate temperature control under a variety of ambient temperature and turndown conditions.
US08574337B2 Renewable resource-based metal-containing materials and applications of the same
A method of producing carbon-metal nanocomposites includes (a) treating a material containing at least one o-catechol unit with a first solution of hexamine such that the material becomes hexamine treated; (b) treating the material with a second solution having a plurality of metal ions such that the material becomes metal treated; (c) treating the material with a third solution of alkali such that the material becomes alkali treated; and (d) heating the alkali, metal and hexamine treated material after (a), (b), and (c) for a predetermined period of time such that a plurality of carbon-metal nanocomposites having metal nanoparticles dispersed in the material are produced.
US08574329B2 Method of operating a gasifier
A method of operating a gasifier is provided that envisions dividing the gasifier into multiple zones. A high-calorific-value feedstock with an oxidant is injected in the first zone. The gasifier is operated to substantially consume the oxidant within the first gasification zone. The method of operating the gasifier further includes injecting a low-calorific-value, high-oxygen-content feedstock in a second gasification zone. The low-calorific-value, high-oxygen-content feedstock is devolatilized and gasified in second zone. A method of operation provides for a synergistic co-gasification of the high-calorific-value feedstock and the low-calorific-value, high oxidant content feedstock. The method provides for specific control actions that enable operation of multi-fuel, multizone gasifier.
US08574323B2 Marker compounds for liquid hydrocarbons and other fuels and oils
A compound having formula (I) wherein G represents at least one substituent selected from the group consisting of C1-C12 alkyl and C1-C12 alkoxy.
US08574320B2 Press apparatus
A press apparatus for assembly of a battery pack includes a tooling table having an aperture formed therein. The tooling table includes a plurality of index pawls disposed adjacent the aperture. The index pawls militate against the components passing upwardly through the aperture after the components have passed downwardly through the aperture. A first press is disposed on a first side of the tooling table and configured to advance the components downwardly through the aperture and past the index pawls on the tooling table. A second press is disposed on a second side of the tooling table. The second press is configured to retract a distance that the components are pressed downwardly through the aperture and maintain a substantially constant upward force on the components. A third press is disposed on the first side of the tooling table and configured to compress the battery pack to a desired size and load.
US08574311B2 Versatile biodegradable elastic polymers featured with dual crosslinking mechanism for biomedical applications
The present invention provides a dual crosslinked biodegradable polymer and methods of making and using the polymer. The dual crosslinked biodegradable polymer composition includes a multifunctional monomer; a diol; and an unsaturated di-acid at least partially polymerized to form a network and photocrosslinked into a dual crosslinked polymer network.
US08574310B2 Stomach peristalsis device and method
The invention relates to an implantable stomach prosthesis for surgically replacing or augmenting all or part of the antrum and/or pylorus of a stomach. The prosthesis controls the passage of food from the stomach to the small intestine. The prosthesis may be configured to churn ingested material and release it from the stomach through a prosthetic pyloric valve. At least one expandable member is arranged to be expanded to control the passage of food and/or to mimic the churning action of a patient's stomach. The prosthesis includes an outer support structure, a flexible inner member forming a conduit for the movement of material, and at least one expandable member located between the outer support structure and inner member. An implantable pump system is provided for inflating and deflating the expandable member(s).
US08574301B2 Systems and methods for spinal fusion
A system and method for spinal fusion comprising a spinal fusion implant of non-bone construction releasably coupled to an insertion instrument dimensioned to introduce the spinal fusion implant into any of a variety of spinal target sites.
US08574298B2 Spinal implant
A spinal implant is provided for retaining spinal elements in a desired spatial relationship. It includes a tensioning member positionable along the spinal column of a patient to match the contour thereof. A pair of buttress members are located each on one of the ends of the tensioning member, at least one of the buttress members being slidable on the tensioning member so that the distance between the buttress members may be adjusted.
US08574295B2 Accommodating intra-ocular lens system
An implantable, compressible, accommodating intra-ocular lens (IOL) coupled to at least one sensor which detects a signal created by the ciliary muscle. A ciliary sulcus ring can house the at least one sensor, and the sensor can include miniaturized electrodes (ciliary muscle probes) for implanting into the ciliary muscle of the subject. A potentiometer/microcomputer can modulate the ciliary muscle signal detected by the sensor(s) into an electrical signal, and a transmitter sends this electrical signal to a micromotor, which causes compression of the IOL via an annular support ring system, causing a change in the IOL shape. The IOL can be part of an IOL complex including a compressible, accommodating IOL, an external lens membrane, and an annular support ring system. The annular support ring system provides a foundation for the micromotor to compress the IOL.
US08574293B2 Method and device for manipulation of an intraocular lens
This device for stretching the haptics of an intraocular lens has at least two haptic guiding surfaces, a seat arranged with respect to the guiding surfaces so as to allow contact between a first point on each haptic and its corresponding guiding surface, and a lens guiding arrangement operable to allow the lens positioned in the seat to be moved along a path in the optic axis direction to bring at least a second point on each haptic into contact with, or closer to, its corresponding guiding surface and to orient each haptic in a less curved state, wherein the guiding surfaces extend in opposite directions from a channel operable to receive the lens.
US08574291B2 Linear drive and pump system, in particular an artificial heart
The invention relates to an electrical linear drive, in particular for a pump system of an artificial heart, with a movable part and a stationary part, wherein the stationary part is formed by a permanent magnet arrangement and the movable part is formed by a coil arrangement, or vice versa, and wherein the coil arrangement and the permanent magnet arrangement can be moved to and fro relative to each other in an axial direction by means of current passed through the coil arrangement. The invention further relates to an electrical linear drive of this kind in which the permanent magnet arrangement is designed as a stack of frame-shaped, in particular ring-shaped magnets, which are magnetized alternately radially and axially in the axial direction, such that the magnetic field is strengthened on one side of the frame.
US08574289B2 Inflatable minimally invasive system for delivering and securing an annular implant
A delivery device for an annular implant that includes a balloon expansion mechanism and an annular implant having an adjustable dimension. The balloon expansion mechanism includes an inflation tube attached to a non-occluding balloon collar which is supported by trusses radially extending from a trocar. The annular implant further includes a flexible ring core, contiguous coiled spacers, and anchoring blocks. The flexible ring core is adjusted via a cinching mechanism. The anchoring blocks are spaced along the ring core by the contiguous coiled spacers, which keeps the distance between each pair of anchoring blocks equidistant as the ring core diameter is manipulated by the device user. The annular implant can also include gunbarrel elements housed in the trocar. Each gunbarrel element contains a gunbarrel pusher which drives an attachment element into the annular implant and annular tissue.
US08574288B2 Side branch stent graft construction
A stent graft has a tubular body of a biocompatible material and at least one fenestration. A tubular side branch is stitched into the fenestration with a portion of the side branch extending within the tubular body and a portion of the side branch extending exteriorly of the tubular body. The stitching by which the side branch is mounted into the fenestration extends circumferentially and diagonally from one end of the side branch to the other such that the side branch extends from the tubular body at an angle thereto. The tubular side branch may have a reinforcement stent having at least one helical wire segment.
US08574287B2 Stents incorporating a plurality of strain-distribution locations
A stent (120) has proximal and distal ends (140, 142), and is configured to assume radially-compressed and radially-expanded states. The stent (120) comprises a plurality of circumferential bands (122) disposed about a longitudinal axis (123) of the stent (120), each of which bands (122) comprises a plurality of struts (124) connected to one another. At least one of the bands (122) is shaped so as to define a plurality of distally-directed peaks (126) alternating with a plurality of proximally-directed troughs (128), and one or more strain-concentration modules (132). Each of the modules (132) has a central axis (156) parallel to the longitudinal axis (123) of the stent (120), and comprises: (a) an open loop section (150), which comprises one of the distally-directed peaks (126); (b) a primary neck section (152); and (c) a secondary section (154). Other embodiments are also described.
US08574286B2 Bend-capable stent prosthesis
Normally, when stents are bent, inside the body of the stented patient, there is head-to-head collision between facing V-points on the inside of the bend. However, by alternating between two whole numbers the number of struts between successive connectors around the circumference of each of the stenting rings, the V-points are caused to veer circumferentially in opposite directions as they approach each other on the inside of the bend, so allowing them to pass by each other without collision, thereby allowing in the same stent both close packing of the ring stack, and an enhanced ability to tolerate severe bending, after placement in the body.
US08574275B2 Fixation device for delivery of biologic material between soft tissue and bone
A fixation device for delivery of biological material between soft tissue and bone. The fixation device includes an anchor having a first longitudinal bore and a first radial extending delivery bore and an insert having a second longitudinal bore and a second radial extending delivery bore. The first and second radial extending bores are aligned and positioned relative to a head of the anchor to deliver the biologic material between the soft tissue and the bone.
US08574268B2 Highly-versatile variable-angle bone plate system
A bone plate system for internal fixation of bone fractures includes a bone plate having a plurality of bone plate holes. The holes are constructed to receive either a non-locking, locking, or variable-angle locking bone screw. The holes have discrete columns of teeth or thread segments arranged around the inner surface of the hole for engaging threads on the heads of locking and variable-angle locking bone screws. Conventional locking bone screws engage the bone plate coaxially with the central axis of the bone plate hole. Variable-angle locking bone screws can engage the bone plate at a selectable angle within a range of selectable angles relative to the central axis of the bone plate hole. The head of the variable-angle locking screw is at least partially spherical, and the thread thereon has a profile that follows the arc-shaped radius of curvature of the spherical portion of the screwhead.
US08574267B2 Assembleable jack braces for seating and supporting angular processes
An insert for establishing a desired spacing between a pair of succeeding vertebrae and having a body including an extending end for supporting a location associated with a first selected lumbar vertebrae. An opposite extending end supports a spaced apart and opposing location associated with a second successively positioned lumbar vertebrae. Upon pre-positioning the body in an open space established between the vertebrae, an actuating input causes the first extending end to displace outwardly relative to the second end and into contacting support with the vertebrae.
US08574265B2 PFO closing device
A PFO closing device for bringing the septum primum and the septum secundum into contact with each other and joining them together includes a clamping mechanism and energy supplying device. The clamping mechanism includes a needle part for puncturing the septum primum, and a clamping member for cooperating with the needle part in clamping therebetween tissue of the septum primum and the septum secundum. The energy supplying device supplies energy for joining the tissues clamped by the needle part and the clamping member. The clamping mechanism is mounted in a catheter so as to be protrudable from and retractable into the catheter.
US08574263B2 Coaxial coil lock
A surgical instrument includes a housing and an elongated shaft extending distally therefrom. The elongated shaft includes a proximal portion, a distal portion and a flexible portion supported therebetween. The flexible portion permits pivotal movement of the distal portion of the elongated shaft and an end effector supported thereon. A locking mechanism is operatively associated with the flexible portion of the elongated shaft to selectively impede pivotal motion of the distal portion. The locking mechanism includes a locking coil disposed about an axis defined by the flexible portion of the elongated shaft. A distal end of the locking coil is coupled to the distal portion of the elongated shaft, and a proximal end of the locking coil is rotatable about the longitudinal axis to laterally approximate the locking coil to flexible portion, and thus frictionally engage the flexible portion of the elongated shaft to selectively impede articulating motion thereof.
US08574257B2 System, device, and method for providing access in a cardiovascular environment
A device to be used in a cardiovascular environment, comprising an expandable element that is coupled to a rod and that includes a compressed state and an expanded state. The expandable element is operable to be positioned within a wall of an organ while the expandable element is in the compressed state. The expandable element is further operable to be deployed once it is within the organ such that it is in the expanded state. The device further includes a cutter element operable to make a circular incision at the wall of the organ. The expandable element creates a resistive force when it is pulled against the wall while in the expanded state such that an interface is created for making the incision. The device includes a stop-grip mechanism that maintains the resistive force at the interface. One embodiment features the expandable element being umbrella shaped.
US08574256B2 Method of performing a suprapubic transurethral cystostomy
A suprapubic transurethral cystotomy apparatus and method of forming a surgical opening therewith. The apparatus includes an elongate tubular body including a proximal portion and a distal portion inclined relative to one another. The distal portion extends along an axis to an end configured for receipt through a urethra. An elongate arm has a first end operably attached to the proximal portion of the tubular body and a second end providing an indicator establishing an axis aligned coaxially with the axis of the distal portion. A surgical opening is formed with a cutting member being extended along the axis of the indicator.
US08574244B2 System for closing a puncture in a vessel wall
A device is provided herein for deploying a suture in a puncture through a vessel wall of a blood vessel, the puncture disposed within a tissue tract of a patient body. The device includes a shaft suitable for insertion along the tissue tract and into the vessel through a puncture, a plurality of needles, each needle having a proximal end and a distal end suitable for forming a needle path through the vessel wall, wires associated with each needle, each wire having a distal end and a proximal end, and hooks coupled to each of the distal ends of each wire, each hook being configured to anchor the wire to an interior portion of the vessel wall.
US08574243B2 Apparatus and methods for forming and securing gastrointestinal tissue folds
Apparatus and methods are provided for forming a gastrointestinal tissue fold by engaging tissue at a first tissue contact point and moving the first tissue contact point from a position initially distal to, or in line with, a second tissue contact point to a position proximal of the second contact point, thereby forming the tissue fold, and extending an anchor assembly through the tissue fold from a vicinity of the second tissue contact point. Adjustable anchor assemblies; as well as anchor delivery systems, shape-lockable guides and methods for endoluminally performing medical procedures, such as gastric reduction, treatment of gastroesophageal reflux disease, resection of lesions, and treatment of bleeding sites; are also provided.
US08574240B2 Stabilization system and aspiration device with protected cutting edge
A device performs a myringotomy and includes a main body, a hollow positioning member, a cutting edge for piercing a tympanic membrane, a protective sheath and an actuator. The main body is oriented along an axis and has a proximal end, a distal end and an outer surface. The main body includes an attachment hub for receiving components that provide suction. The hollow positioning member extends at least partially along the axis, is coupled to the main body and includes a distal end. The actuator is located on the main body and is configured to move the protective sheath from a first position that surrounds the cutting edge to a second position that exposes the cutting edge and from the second position back to the first position.
US08574239B2 Intraocular lens insertion device
An intraocular lens insertion device for inserting an intraocular lens capable of securely and safely pushing out the lens by a simple structure. An intraocular lens insertion device (1) comprises: a main body (3) having a lens placement portion (8) on which the lens (2) with a pair of loop parts (2b) at its optic part (2a) is placed, a transition portion (12) deforming the lens (2), and a nozzle portion (11) discharging the lens (2); and a lens push-out mechanism (4) pushing out the lens (2) placed on the lens placement portion (8). The lens push-out mechanism (4) comprises a plunger (16) pushing out the lens (2) and a slider (15) having a lens contact part (20) larger than the plunger (16). The slider (15) comprises an operating part (23) projected to the outside of the body (3).
US08574238B2 Instruments, kit and method for suture management
A cannula has a flange and a body with slots extending through the entire flange and into the body. The cannula may also have a longitudinal slot extending its entire length. An obturator used with the cannula may also have a longitudinal slot extending along its length. A surgical method using these instruments includes separating lengths of suture and managing the suture by placing lengths of suture in the slots in the cannula. The cannula and obturator may be used after suture is already in place by placing the suture in the longitudinal slots and then introducing the cannula and obturator to the tissue defect site. The cannula may also be used to deliver a therapeutic implant to the tissue defect site. The instruments and method may be used in mensical surgery.
US08574237B2 Method and apparatus for predicting the operating points of bone cement
A method of predicting the operating state of a curable bone cement composition includes determining the impedance of the bone cement composition. The impedance is used to predict a number of operating states of the bone cement composition including end-of-work time and setting time.
US08574234B2 Fracture fixation system
A method for repairing a fractured bone includes providing a bone fracture fixation assembly including a plate, an elongated shaft, and a rod. At least a portion of the shaft is threaded, and the shaft has a hole extending therethrough. The hole has an axis transverse to a longitudinal axis of the shaft. The method further includes positioning the plate adjacent the surface of the fractured bone, extending the shaft into the bone, cooperatively engaging the threaded portion of the shaft with a screw receiving aperture of the plate, extending the rod into the bone, and inserting the rod into the hole of the shaft.
US08574233B2 Photodynamic bone stabilization systems and methods for reinforcing bone
Photodynamic bone stabilization systems are disclosed herein. In an embodiment, a photodynamic bone stabilization system includes a catheter having an elongated shaft with a proximal end adapter, a distal end releasably engaging an expandable portion, and a longitudinal axis therebetween; a light-conducting fiber configured to transmit light energy to the expandable portion; a light-sensitive liquid monomer comprising an initiator, wherein the initiator is activated when the light-conducting fiber transmits the light energy to initiate polymerization of the light-sensitive liquid monomer; and a cooling medium configured to control polymerization temperature, wherein the catheter comprises an inner void sufficiently designed to pass the light-sensitive liquid monomer into the expandable portion, and wherein the catheter comprises an inner lumen sufficiently designed to pass the light-conducting fiber into the expandable portion and configured to circulate the cooling medium.
US08574232B1 External fixation connection rod for rapid and gradual adjustment
An external fixation connection rod that allows for rapid and gradual length adjustment. In some embodiments, the fixation connection rod includes an inner sleeve received within a telescopic rod to allow for rapid adjustment of an overall length of the fixation connection rod. In some embodiments, the fixation connection rod includes an adjustment mechanism to allow for gradual adjustment of the overall length of the fixation connection rod by lengthening or shortening a threaded elongated member within the inner sleeve, and the adjustment mechanism includes a first rotation member, a second rotation member, and a spring. Distal translation of the first rotation member relative to the second rotation member allows the adjustment mechanism to move from a first, locked position to a second, unlocked position, allowing the first rotation member and the second rotation member to rotate about the inner sleeve and the threaded elongated member during gradual adjustment.
US08574228B2 Ultrasound treatment system
An ultrasound treatment system comprises an ultrasonic transducer, a handpiece, a probe, a sheath, a clamping member, an operation unit, an operating member, a suction base, and a perfusion base. The ultrasonic transducer generates ultrasonic vibrations. The handpiece has the ultrasonic transducer incorporated therein. The probe is connected to the ultrasonic transducer for transmitting ultrasonic vibrations to a distal member realizing a stationary portion that is a treatment portion for treating a living tissue. The sheath serves as a protecting member for shielding the probe. The clamping member is opposed to the distal member at the distal end of the sheath for clamping a living tissue in cooperation with the distal member. The operation unit is manipulated for clamping a living tissue with the clamping member and distal member or freeing the living tissue therefrom.
US08574226B2 Method for treating tissue
This invention relates to a novel surgical device scalable to small dimensions for thermally-mediated treatments or thermoplasties of targeted tissue volumes. An exemplary embodiment is adapted for fusing, sealing or welding tissue. The instruments and techniques utilize a thermal energy delivery means, for example an electrical energy source, to instantly elevate the temperature of a biocompatible fluid media within an electrically insulated instrument portion. The altered media which may then be a gas is characterized by a (i) a high heat content, and (ii) a high exit velocity from the working end, both of which characteristics are controlled to hydrate tissue and at the same time denature proteins to fuse, seal, weld or cause any other thermally-mediated treatment of an engaged tissue volume—while causing limited collateral thermal damage and while totally eliminating electrical current flow the engaged tissue volume. The system can further utilize a piezoelectric material that carried fluid channels to apply compressive forces to the fluid eject the fluid from the working end of make it require less electrical energy to convert it to a gas.
US08574220B2 Rotate-to-advance catheterization system
A method for visualizing the interior of a bodily passageway, comprising providing a visualization system comprising an endoscope comprising a rotatable drive collar configured for rotation relative to the endoscope; a disposable drive tube comprising an elongated tube having a deformable helical thread disposed on an exterior surface of the elongated tube, the elongated tube being configured for coaxial disposition about the endoscope; and a mount for releasably securing the drive tube to the drive collar; mounting the drive tube coaxially about the endoscope so that the drive tube is secured to the drive collar of the endoscope; inserting the visualization system into the passageway, with the helical thread being in a reduced profile configuration; transforming the helical thread into an expanded profile configuration; rotating the drive tube so as to bring together a site which is to be visualized and the visualization apparatus; and visualizing the passageway.
US08574218B2 Catheter, fluid conveying method, and percutaneous procedure
A catheter includes an elongate catheter body having an outer surface with a non-uniform contour and including a plurality of maximum surface elevation points and a plurality of minimum surface elevation points defining a non-uniform elevation profile relative to a longitudinal axis of the catheter body. The outer surface further includes a fluid transfer interface which includes the plurality of minimum surface elevation points and a plurality of porous surface areas, and a tissue contact interface which includes the plurality of maximum surface elevation points and a plurality of nonporous surface areas. The tissue contact interface inhibits external occlusion of the fluid transfer interface during transferring fluid between a fluid lumen defined by the elongate catheter body, and an intraluminal space such as an intravascular space within a patient.
US08574217B2 Sub-mucosal agent delivery method for the eye
An agent delivery apparatus for administering a pharmacological agent formulation to a sub-mucosal compartment of a body organ, comprising injector means having an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein and an elongated agent delivery member having a first end that is in communication with the internal formulation chamber and a delivery nozzle end, the injector means including force generating means that is adapted to generate sufficient force to expel the pharmacological agent formulation from the injector means and into and through the agent delivery member, and out of the delivery nozzle end of the elongated agent delivery member with a delivery pressure in the range of approximately 50-1000 psi.
US08574212B2 Absorptive article including waistline stretching regions
An absorptive article has an absorptive article body, a pair of side flaps, and a pair of waist flaps provided in the rear region so as to extend outward from the side flaps in the lateral direction of the absorptive article body. Each of the pair of waist flaps has formed thereon a waist stretchable region extended so as to reach that edge of the waist flap which is on the belly side. The waist stretchable regions are adapted such that the dimension of the waist stretchable region stretched at the end thereof on the belly side in the lateral direction of the absorptive article body is greater than the dimension of the waist stretchable region stretched at the end thereof on the rear side in the lateral direction of the absorptive article body.
US08574210B2 Tampon with improved absorption capacity
The present invention relates to a tampon (1) having an insertion end (11), a withdrawal end (14) and a tampon body in between whereby said tampon body essentially consists of liquid absorbing material and has an outer circumferential surface which is provided with longitudinal grooves (4, 4′) that are separated from each other by longitudinal ribs (3, 3′), wherein at least one tampon groove (4) is defined an outer longitudinal path (2) on the surface of the tampon that diverges from the longitudinal path of the groove below the surface of the tampon. It also relates to a press, press jaw and process for its manufacture.
US08574208B1 Disposable waste bag
A disposable waste bag to be used in the management and collection of a user's urine and fecal matter in places where sanitary facilities do not exist or other situations that make the use of the present invention desirable. A sheet having a substantially truncated triangular shape having a front end and a larger rear side with two lateral rear ends. A rim with a narrow portion is cooperatively shaped to cover the user's genitalia. An enlarged portion of the rim covers the perianal area. The rim is slightly stiffer than the sheet member and extends symmetrically and longitudinally from the first end towards the rear side. The rim is preferably provided with a sealing adhesive to prevent the collected urine and feces from spilling out. A belt is used around a user's waist to keep the bag in place.
US08574207B2 Two-piece ostomy device with guiding aid for coupling
The invention relates to a two-piece ostomy device comprising a base plate for adhering to the skin surrounding a stoma and a releasable collecting bag for collecting output from said stoma. The base plate is releasably connectable to the collecting bag via a first annular flange arranged on the base plate and a second annular flange arranged on the collecting bag. An adhesive is at least partly disposed on at least one of the flanges. The ostomy device further comprises a first through-going hole extending through the first annular flange along a first axis and a second through-going hole extending through the second annular flange along a second axis, wherein the ostomy device further comprises a guiding aid for arranging the first annular flange and the second annular flange in a guiding configuration. In the guiding configuration the movement of the first and the second flange is limited relative to each other in one plane being defined by the first and the second axis and in rotation around at least one of the first or the second axis. The limited movement of the base plate and the collecting bag provides a two-piece system which is easier to apply correctly and thus reduces the risk of leakage.
US08574205B2 Device for the cutaneous application of substances
The present disclosure provides a device (1) for the cutaneous application of a substance (2) that contains: a patch (3) containing the substance (2); and a single-use wrist strap (4) containing an irreversible attachment system for maintaining the substance (2) of the patch (3) against the skin of a subject.
US08574204B2 Implantable medical device for improved placement and adherence in the body
A medical device comprises a flexible member that can be adhesively attached to a housing of the medical device, allowing implantation of the medical device into a body through an incision of reduced size. The flexible member can be attached to the housing either before or after implantation into the body. The flexible member comprises suture locations, including a permeable membrane or a suture hole, for suturing the medical device to tissue of the body. The suture holes can be filled with a substance penetrable by a suture needle, to minimize tissue ingrowth before or after suturing.
US08574197B2 Huber needle safety enclosure
A safety enclosure for a Huber needle includes a needle housing and a panel unit. The panel unit includes a series of planar panels assembled in an enclosing arrangement defining an enclosed area and is movable between an installation position where the sharp outer end of the Huber needle projects from the panel unit and a safety position where the sharp outer end is covered by the panels. The Huber needle has an aft end and a fore end connected by a bend with the fore end including a sharp outer end.
US08574195B2 Systems and methods for detecting tissue contact and needle penetration depth using static fluid pressure measurements
Systems and methods for determining tissue contact and penetration depth are provided. In one aspect, the system includes a needle and a pressure measurement assembly. The needle, in one exemplary embodiment, includes a first end and a second end with at least one aperture located a predetermined distance from the first end. The fluid pressure measurement assembly is connected with a portion of the needle to measure pressure of fluid dispensed in the needle. The fluid pressure measurement assembly measures a first pressure of the fluid, a second pressure when the needle contacts tissue and a third pressure when the needle penetrates the tissue and the aperture becomes occluded.
US08574194B2 Injection site marking method
An injection site marking method and apparatus includes a base member having a continuous side wall defining an open top, an open bottom, and an interior area. The open bottom is configured to attach selectively to a serum vial. A liquid retention member is positioned in the interior area and configured to hold a colorized viscous liquid. A cap having a continuous side wall defining an open bottom and interior area is connected to the base member such that the liquid retention member is unexposed. The cap includes a top wall defining an aperture. In use, a syringe may be inserted through the aperture, through the liquid retention member, and into a serum vial so as to withdraw serum and such that the syringe reservoir nose contacts the viscous liquid. The needle is injected into a user's skin until the syringe reservoir nose contacts the skin with the colorant.
US08574187B2 System and method of an electrosurgical controller with output RF energy control
An electrosurgical controller with output RF energy control. At least some of the illustrative embodiments are electrosurgical controllers configured to change a first output voltage on the first active terminal relative to the first return terminal by selective control of a number of turns of the primary winding of a transformer used to create the output voltage.
US08574184B2 Systems and methods for treatment of obesity and type 2 diabetes
The present invention provides systems and methods for treating and controlling obesity and/or type II diabetes. In one aspect of the invention, a device comprises a hollow sleeve sized and shaped for positioning within a duodenum of the patient, an anchor coupled to the proximal end of the sleeve and being sized and shaped to inhibit distal migration of the sleeve and a plurality of elastomeric objects coupled to the distal end of the sleeve and being sized and shaped to inhibit proximal migration of the sleeve through a pylorus of the patient. The bypass device can be placed and removed endoscopically through the patient's esophagus in a minimally invasive outpatient procedure and it is “self-anchoring” and does not require invasive tissue fixation within the patient's GI tract, thereby reducing collateral tissue damage and minimizing its impact on the digestive process.
US08574182B2 Restraint device and method of use
A restraint device includes first and second restraint and/or support portions adapted to extend around part of a person. First and second connector portions may secure the first and second restraint and/or support portions to the person. A lock member may be used to selectively prevent disconnection of the first and second connector portions. One or more removable tags or other information elements may be carried on at least one of the first and second restraint and/or support portions and may indicate who placed the restraint device on, or removed the restraint device from the person, and/or what time the restraint device was placed or removed. The tags or other elements may include a unique identifier to indicate whether the restraint device had been previously removed from the person after an initial placement. The restraint device may include an electronic information element configured to transmit information related to the wearer.
US08574181B2 Ankle walker
An ankle walker including an ankle shell, an inner lining, at least one bladder and at least one strap is provided. The ankle shell includes a base, a lower foot portion, a first and second side panel and a back panel. The lower foot portion extends upward from the base. The first side panel and second side panel extend from respective first and second portions of the lower foot portion. The back panel extends from a third portion of the lower foot portion and is positioned between the first and second side panels. The ankle shell has a first slot separating the first side panel from the back panel and a second slot separating the second side panel from the back panel. At least one of the first and second slots has a height that is at least one half the height of the ankle walker.
US08574179B2 Enhanced biomechanical stimulation device
A biomechanical stimulation device is presented. The biomechanical stimulation device comprises a base that supports an adjustable height arm and an easily removable drum connected to the arm. The drum is driven by a motor to provide an elliptical stimulation motion. An anti-rotation device prevents rotation, but allows orbital translation of drum. The drum may connect to the arm at a single attachment point. The arm 20 may be pivotally attached to the base and selectively movable to a desired position. A pair of struts may support the arm to assist in positioning the arm. The struts may be locked to prevent movement of the arm, or unlocked by a release button to allow selective positioning of the arm. The biomechanical stimulation device may further include a hand controller and other peripheral devices to provides a convenient interface for controlling the speed and run time of the biomechanical stimulation device.
US08574178B2 Wearable power assistive device for helping a user to move their hand
A rehabilitation system for training hand movement of a user, the system comprising: a platform to be attached to the hand of the user; a plurality of finger assemblies operatively connected to the platform, each finger assembly having: a motor, a proximal follower assembly for a metacarpophalangeal (MCP) joint having a proximal rail guide operatively connected to the motor, and an intermediate follower assembly for a proximal interphalangeal (PIP) joint having an intermediate rail guide operatively connected to the proximal follower assembly; wherein a knuckle joint indicator of the proximal rail guide corresponds to a first virtual center and knuckle joint indicator of the intermediate rail guide corresponds to a second virtual center, the alignment of the knuckle joint indicators to the virtual centers enable motion of the finger to be controlled and maintain rotational axes of the finger about each virtual center when the proximal and intermediate follower assemblies are actuated by the motor.
US08574173B2 Motor function estimating system, motor function estimating method and program
The motor function estimating system 1000 has a memory unit 1260, a data processing unit 1220 (analyzing section), and a display unit 1400. The memory unit 1260 memorizes waveform data about the time change of fingers tapping motion that is obtained by a motion sensor attached to a subject person who does the fingers tapping motion that is repetition of the opening and closing motion of two fingers of one hand. The data processing unit 1220 analyzes the waveform data in the memory unit 1260. The display unit 1400 displays an analysis result. The data processing unit 1220 creates motion waveform based on waveform data, and plural characteristics based on the motion waveform. The data processing unit 1220 creates a motion disorder synthesis value that represents degree of motion disorder of the subject person by revising each of the plural characteristics based on characteristics of every age and synthesizing them.
US08574168B2 Method and apparatus for a multi-use body fluid sampling device with analyte sensing
A device for use with a penetrating member driver to penetrate tissue is provided. A plurality of penetrating members are coupled to a single cartridge and are operatively couplable to the penetrating member driver. The penetrating members are movable to extend radially outward from the cartridge to penetrate tissue. A plurality of analyte sensors are coupled to the single cartridge and are positioned on the cartridge to receive body fluid from a wound in the tissue created by the penetrating member.
US08574166B2 Dual mode intracranial temperature detector
Apparatus for detecting thermal radiation emanating from two different intracranial depths in a patient includes a transducer having a surface for placement against the patient's cranium. The transducer includes a first antenna with an aperture adjacent that surface the antenna being tuned to a first frequency and producing a first signal indicative of thermal radiation received within an antenna pattern extending a first distance from the surface and a second antenna having a second aperture adjacent to that surface within the first aperture. The second antenna is tuned to a second frequency and produces a second signal indicative of radiation received within an antenna pattern extending a selected second distance from the working surface, the second distance being shorter than the first distance. The two signals are coupled to a receiver/control unit which thereupon monitors and displays the temperature at the two intracranial depths.
US08574163B2 Apparatus and method for a noninvasive estimate of the characteristics of a periodic/cyclic bodily sound in a region close to its source
Methods and apparatus for noninvasively determining a sound pressure of a source that transmits a generally periodic acoustic signal including at least one signal component to a surface of a body are provided. The signal component at the surface of the body is received and an initial phase-inverted signal component is estimated responsive to the received signal component. The phase-inverted signal component, advanced by a predetermined time increment, is transmitted toward the source via the surface. The predetermined time increment corresponds to a distance of the signal component within the body. At least one feature of the transmitted signal component is adjusted until a further received signal approximates a minimum value. The adjusted signal component corresponds to the signal component at the distance. The apparatus determines the phase-inverted signal component that corresponds to the signal component being proximate to the source.
US08574160B2 Needle guides for a sonographic imaging device
Needle guide systems for a sonography device are disclosed. The needle guide systems include both fixed and adjustable needle guides. In one embodiment, the needle guide includes a needle guide body that is rotatably mounted to a probe of a sonography device. A plurality of needle channels is disposed on a surface of the needle guide body. Each needle channel can be selectively rotated into position to guide a needle into a body of a patient at a predetermined needle insertion angle. If another needle insertion angle is desired, the needle guide is rotated to place a new needle channel defining the desired needle insertion angle into position.
US08574159B2 Thermally enhanced ultrasonic probe
The present invention relates to an ultrasonic probe provided with a piezoelectric element for ultrasonic generation that has drive electrodes formed on two main surfaces thereof; an acoustic matching layer formed on the first main surface side of the piezoelectric element; a backing member attached to the second main surface side of the piezoelectric element; a base for heat dissipation provided on a lower surface of the backing member; and a thin metal plate for heat transfer that is thermally bonded between at least one of the main surfaces of the piezoelectric element and the base for heat dissipation; wherein the thin metal plate for heat transfer is surface-bonded to extend from one end of the piezoelectric element over the center thereof toward the other end. This configuration ensures that heat generated by the electrical-mechanical conversion of the piezoelectric element is transferred away in a satisfactory manner, enabling suppression of any temperature rise in the piezoelectric element.
US08574156B2 Determination of the clinical state of a subject
The invention relates to the determination of the clinical state of a subject. A respective adaptive transform is applied to at least one measurement signal acquired from the subject, each adaptive transform being dependent on previously acquired history data, and a diagnostic index is formed, which is dependent on the transformed measurement signal(s) and serves as a measure of the clinical state of the subject. In order to reliably evaluate the clinical state of a subject on a fixed diagnostic scale during changes in the state of the subject, some or all of the previously acquired history data on which an adaptive transform is currently dependent is replaced with other previously acquired history data when a predetermined event is detected. The predetermined event is indicative of a change in the respective measurement signal, and the introduction of the said other previously acquired history data sets the transform ready for the change.
US08574155B2 Expandable surgical access port
A surgical access assembly is disclosed that is configured and dimensioned for positioning within an opening in tissue providing access to and internal body cavity to facilitate the passage of a surgical instrument into an internal work site. The surgical access assembly includes first and second arms and third and fourth arms. The first and second arms and the third and fourth arms are configured and dimensioned for relative movement such that the surgical access assembly is reconfigurable between a first configuration, wherein a first transverse dimension is defined, and a second configuration wherein a second transverse dimension is defined. The first transverse dimension is smaller than the second transverse dimension.
US08574154B2 Retractor component system and method comprising same
A blade assembly has a blade body and a blade body surround. A retractor attachment structure is attached to the blade body at the first end portion thereof extending from an exterior surface thereof. The retractor attachment structure is configured for having one of the blade body mounting structures of the retractor engaged therewith in a manner whereby the blade body is independently pivotable about and translatable along the blade body mounting structure. An alignment member protrudes from an interior surface of the blade body adjacent its first end portion. A slot extends through the blade body at its first end portion. The blade body surround and the blade body jointly form a generally cylindrical-shaped structure when the blade body is in a seated position within the slot. The cylindrical structure defines a central passage extending between the first and second end portions of blade body surround.
US08574153B2 Flexible port seal
A flexible port seal is provided for use in single incision surgery and includes an outer seal defining a bore extending from a proximal end of the outer seal to a distal end of the outer seal. A support plate is located within the bore of the outer seal and one or more throughports are attached to the support plate for receipt of a surgical instrument. The throughports form a fluid tight seal with cannulas and/or surgical instruments inserted through the throughports. The flexible port seal is formed of a compressible or flexible material to facilitate insertion through the single incision in the patient and allow for movement of the surgical instruments relative to the seal to independently orient each of the surgical instruments.
US08574152B2 Process and arrangement for the production of a signal that corresponds to the opening status of the vocal cords of the larynx
An arrangement is described in which an endoscope 3 inserted into the pharynx of the patient B is used to visually examine the vibrations of the vocal cords 2, while using light that contains little or no infrared light. At the same time, an oscillogram of the vibrations of the vocal cords is plotted, showing the sequence of motion of the vocal cords. The latter purpose is served by an emitter 1, which is attached to the throat of the patient B below the vocal cords 2 and which produces light in the near infrared range (NIR). Using a mirror 5 that reflects infrared light, the light modulated by the vibration of vocal cords is coupled out and fed to a sensor 6, which, together with an evaluating unit 9, detects and evaluates the vocal cord signals.
US08574148B2 System for introducing soft tissue anchors
A system for providing support to an anatomical structure of the pelvis includes first and second soft tissue anchors, a suburethral support, an introducer, and a filament. The first soft tissue anchor has a proximal end and a distal end and includes a base having a hollow tubular structure, a plurality of barbs, and a tip. The sub-urethral support portion has first and second ends, the first and second soft tissue anchors extending from the first and second ends of the sub-urethral support portion. The introducer has an elongate shaft and a handle, the elongate shaft having a proximal end at the handle and a distal end with an aperture extending through the distal end. The filament extends through the hollow tubular section of the first soft tissue anchor and through the aperture in the distal end of introducer.
US08574146B2 Implant with high vapor pressure medium
An implant for use in a human or animal body can include a flexible housing with an outer wall and having a chamber therein. The implant can have at least one high vapor pressure medium within the chamber. The at one high vapor pressure medium can have a combined vapor pressure equal to or greater than about the average value of the hydrostatic pressure of the implantation site plus the skin tension of the housing minus the gas tension of the dissolved gasses present at the implantation site.
US08574135B2 Ball-hitting glove assembly for boxing training
A ball-hitting glove assembly for boxing training has a glove, a ball and a rope. The glove has a palm section, a hand back section and a finger section. The rope is mounted securely on the glove and has a glove end and a ball end. The glove end of the rope is mounted securely on the hand back section. The ball end is opposite to the glove end of the rope. The ball is mounted securely on the ball end of the rope. The ball-hitting glove assembly is easily carried and is convenient for boxing-training at any time when a user travels or exercises outside. This is greatly practical for those who like boxing.
US08574132B2 Trampoline with sleeve joint coupling
A trampoline is disclosed that includes first, second, and third frame members, a pole member, and a sleeve joint coupling. The sleeve joint coupling includes a first arm with a first passage, a second arm with a second passage, a third arm extending away from the second arm and including a third passage, and an aperture. The first passage has a first axis, and the second and third passages shares a substantially common axis. The first axis is substantially perpendicular to the substantially common axis. The first frame member is received in the first passage, the second frame member is received in the second passage, the third frame member is received in the third passage, and the pole member is received in the aperture to extend away from the first frame member. At least one of the second and third arms defines an uppermost surface of the sleeve joint coupling.
US08574130B1 Total body exercise methods and apparatus
An exercise apparatus includes a frame, a footpad for supporting a user's foot, and a sensor that generates a force indicating signal indicative of a force applied to the footpad in a horizontal direction by the user's foot. A mechanism couples the footpad to the frame and guides the footpad in a closed path having at least first and second mutually perpendicular dimensions in response to forces applied to the footpad by the user's foot, the first dimension being parallel to said horizontal direction. The mechanism resists movement of the footpad in the horizontal direction in response to an electrical control signal supplied as input to the mechanism. A control system receives the force indicating signal and generates the control signal such that the mechanism resists movement depending on the force indicated by the force indicating signal.
US08574128B2 Control apparatus for a vehicle
Providing a control apparatus for a vehicle having a parking lock device 50 which is placed in its released state with a hydraulic pressure generated by an oil pump 58 operated by an engine 26, which control apparatus permits reduction of a risk of unintended releasing of the parking lock device 50 upon occurrence of an operating failure of an ON-OFF switching valve 72 or a switching valve 70 of a hydraulic device 69 provided to supply the hydraulic pressure.Engine start restricting means 92 is configured to restrict starting of the engine 26 when a component of the hydraulic device 69 provided to operate the parking lock device 50 has an operating failure that causes the parking lock device 50 to be held in its released state, as compared with the starting when the component does not have the operating failure, so that the engine start restricting means 92 reduces a risk of releasing of the parking lock device 50 due to application of the hydraulic pressure from the hydraulic device 69 to the parking lock device 50, which application would be caused by the starting of the engine 26.
US08574124B2 Control unit and method to operate a vehicle
A control unit of a motor vehicle for activating a form-locking shift element of a transmission of the motor vehicle in such a way that a defined rotational speed difference is defined, between an input-side component of the form-locking shift element and an output-side component of the form-locking shift element, in order to engage the form-locking shift element. The control unit monitors the rotational speed gradient of the rotational speed of the output-side component of the form-locking shift element from an activation time of the form-locking shift element, at which the engagement process of the form-locking shift element begins. The control unit generates a control signal for a drive assembly in order to increase the torque, at a drive assembly, in the event that the control unit determines that the monitored rotational speed gradient falls below a lower limit.
US08574123B2 Methods and systems for engine control
Systems and methods are provided for restarting an engine that can be selectively deactivated during idle-stop conditions. In one embodiment, the engine is restarted with torque reduction over an interval of the restart, for example, by upshifting the transmission. In response to a vehicle launch request, the torque reduction is decreased, for example, by downshifting the transmission, to expedite return of driveline torque.
US08574121B1 Park disengagement clunk mitigation
A method for controlling a transmission gearshift includes engaging control elements whose engagement is required for operation in first gear and reverse gear without grounding the transmission's input, grounding said input provided a range other than park is selected, grounding the transmission's output, releasing the input, producing first gear provided first gear is selected, and producing reverse gear provided reverse gear is selected.
US08574118B2 Journal pin for gear system
A turbomachine epicyclic gear system includes a sun gear rotatable around an axis, a ring gear radially outward of the sun gear, and a plurality of intermediate gears meshed with the sun gear and the ring gear. A plurality of journal pins are each configured to support one of the plurality of intermediate gears. Each of the plurality of journal pins has an asymmetric rim.
US08574117B2 Mechanism with component position adjusting function
This invention discloses a mechanism with a component position adjusting function, comprising a drive unit, a drive shaft, a plate body, a drive wheel, at least one passive component and a brake. The drive unit performs a forward or reverse rotating shift and drives the drive shaft to rotate. The unidirectional component has a through hole, and disposes at the plate body. An end of the drive shaft is passed through the through hole and exposed from the plate body. The drive shaft synchronously drives the plate body and the drive wheel to rotate forward. The passive component is arranged at the plate body and contacted with the drive shaft with synchronously drives and rotates the passive component. The plate body remains still through the rotation of the unidirectional component and the contact of the brake with the plate body.
US08574111B2 Dual torque limiter
A dual torque limiter on a utility vehicle having a gear train connected to a main shaft through a first slip clutch assembly that releases the gear train from the main shaft if torque exceeds a predetermined limit. The main shaft is connected to a rear drive train. The front drive train is connected to the main shaft through a second slip clutch assembly that releases the front drive train from the main shaft if torque exceeds a predetermined limit.
US08574107B2 Chain tensioner
In a hydraulic tensioner, a tensioner housing is provided with an oil outflow channel communicating with a high pressure oil chamber formed by a plunger and the tensioner housing. A control valve in the oil outflow channel can be adjusted manually or automatically to optimize the damping performance of the tensioner in different engines and under different operating conditions, thereby obviating individualized machining of tensioner components to achieve optimum damping.
US08574102B1 Swing-pitch system
A wand is formed in a hollow cylindrical configuration. The wand has inner and outer ends. A ball has a cylindrical passageway extending diametrically through the ball. An essentially inextensible cord couples the wand and the ball. In this manner a pitcher is adapted to grasp and spin the wand to pitch the ball in a circular manner. Also in this manner a batter is adapted to swing a bat in an attempt to strike the pitched ball for batting practice.
US08574097B2 Golf ball
A golf ball 2 includes a spherical core 4, a mid layer 6 positioned outside the core 4, and a cover 8 positioned outside the mid layer 6. The core 4 includes a spherical center 10 and an envelope layer 12 positioned outside the center 10. The center 10 has a diameter of 1 mm or greater and 15 mm or less. The center 10 has a JIS-C hardness H1, at its central point, of 20 or greater and 50 or less. The difference (H4−H3) between the JIS-C hardness H4 of the core 4 at its surface and the JIS-C hardness H3 of the envelope layer 12 at its innermost portion is equal to or greater than 10. The cover 8 has a flexural modulus of 300 MPa or greater and 1000 MPa or less, and has a tensile modulus of 400 MPa or greater and 1500 MPa or less.
US08574095B2 Golf club head
A golf club head comprises has an inner surface including a back surface of the face portion that is provided with a crown-side thick-walled rib and a sole-side thick-walled rib. The crown-side thick-walled rib includes an upper face rib disposed in the face portion and extending from the central thick-walled part to a peripheral edge of the back surface of the face portion on a crown portion side, and a crown rib disposed in the crown portion and extending backwardly of the head from the upper face rib. The sole-side thick-walled rib includes a lower face rib disposed in the face portion and extending from the central thick-walled part to a peripheral edge of the back surface of the face portion on a sole portion side, and a sole rib disposed in the sole portion and extending backwardly of the head from the lower face rib.
US08574094B2 Club head sets with varying characteristics and related methods
Embodiments of golf clubs head sets with varying characteristics are disclosed herein. Other examples and related methods are also generally described herein.
US08574089B1 Billiards rack system and method of use
A billiards rack system has a rack body and at least two alignment elements. The rack body has at least two inner surfaces that together define an inner area shaped for racking the billiard balls. The at least two alignment elements of the rack body each have an alignment indicia that is shaped to be placed over and visually aligned with alignment marks on a billiards table. The rack body correctly positions billiard balls on the billiards table once the alignment indicia of the alignment elements have been placed over and visually aligned with the alignment marks of the billiards table.
US08574088B1 Pivoting swing
A swing includes an annular track that carries a pair of moveable trolleys. Suspended from the trolleys by flexible suspension members is a support member, such as a swing seat. The support member may be moved to any desired position by moving the trolleys about the track, whereupon the trolleys may be locked in position. Once locked in the desired position, a user seated upon the support member is able to swing back and forth via the flexible suspension members.
US08574085B1 Artificial cave obstacle course with electronic sensing
An obstacle course has the appearance of a natural cave environment. The course may include a plurality of interconnected, hollow, three-dimensional shapes through which human users can pass. The shapes may be modular to allow various different configurations of the course. The shapes may contain models of cave formations (speleothems), with which the users are expected to avoid contact and close proximity. Electronic sensing may be provided for monitoring any contact and proximity of the users to the speleothems, and additional electronic circuitry may be provided to present feedback to the users regarding their performance in the course.
US08574084B2 Vehicle-use propeller shaft
A vehicle-use propeller shaft includes a yoke having four arm portions to disposed at equal intervals in the circumferential direction, each arm portion extending outward in the radial direction. One pair of arm portions and that extend in opposite directions and the other pair of arm portions and that extend in opposite directions have mutually different shapes.
US08574082B2 Button panel mount for a gaming machine cabinet
A gaming machine cabinet has a cabinet door is pivotally connected thereto and movable between a closed and open positions. A cabinet door button panel includes a panel support surface opposite the door's inner side, a capture structure at a first boundary of a button panel opening, and a blocking structure at a button panel second boundary opposite the first boundary. A button panel base has a first edge received in a button panel frame capture structure, and second edge received on the panel support surface. A locking flange with a locking projection extends from the button panel base lower side, the locking projection moveable between extended and retracted positions. With the button panel base in an operating position, a locking projection may be placed in the extended position to contact the blocking structure and thereby retain the button panel base in the operating position.
US08574066B2 Methods and apparatus for a competitive bonus game with variable odds
A bonus controller for generating a competitive bonus game in a gaming system, the bonus controller having a processor and a memory coupled to the processor. The bonus controller being programmed to: receive wagering data corresponding to a casino game, enter a first player associated with a first gaming apparatus into the competitive bonus game when the first player obtains a qualifying win at the casino game, determine odds for the first player to win the competitive bonus game, vary odds of winning the competitive bonus game for at least a second player after entering the first player into the competitive bonus game, the second player having been previously entered into the competitive bonus game, determine an outcome of the competitive bonus game, and transmit data corresponding to the outcome of the competitive bonus game to a display unit.
US08574065B2 Controlling player-to-player commerce in video game environment
Players of a video game can enter contracts and engage in various simple or complex financial transactions employing credit systems such as credit cards, other financial instruments and other mechanisms to facilitate the enforcement of such contracts. Default on agreements by players or player characters can result in financial penalties which the video game system can apply.
US08574063B2 Payout systems and methods
Various embodiments of payout systems and methods are disclosed. One embodiment, among others, comprises providing a defined payout amount and a player adjustable payout volatility for a video gaming device, and responsive to player input, modifying the payout volatility while maintaining the defined payout amount.
US08574057B2 Method for providing a playing card game simulation based on bingo game results
A method includes displaying playing card face representations at an electronic player station. The displayed playing card face representations include card face representations that are included in a group of card face representations that has been assigned to the player in response to a bingo pattern achieved by the player in a bingo game. The player then selects one or more of the displayed card face representations to be replaced with one or more card face representations that are also included in the assigned group but have been concealed from the player. A prize is awarded to the player based on the card face representations remaining in the player's hand after replacement of the selected card face representations. This prize represents the player's prize for achieving the bingo pattern, but is based on the player's card hand produced after the player replaces the desired cards.
US08574045B2 Frost-free vent assembly
A rotatable vent assembly system for areas where breathable airflow is required is disclosed herein. The rotatable vent assembly system improves airflow in any structure where breathable airflow may be a concern, including but not limited to air vacuum vaults, valve vaults, water tanks, pressure reducing valve units, or other confined structures. The rotatable vent assembly system helps reduce frost accumulation within riser pipes during winter months and improves breathable air within confined spaces. By reducing the accumulation of frost, the potential for pipe breakage is reduced, also reducing maintenance and replacement costs to municipalities and property owners for burst pipes. Rotating the vent control component at the top of a riser pipe connected to a pipe system controls the flow of breathable air by increasing or reducing airflow within the pipe system.
US08574043B2 Multifunctional food preparation apparatus
A food processing apparatus including a lower support structure that carries either a food slicing plate or a meat tenderizing plate, an upper structure that carries either a food plunger plate or a meat tenderizing plate; said lower and upper structures being connected with a floating hinge and including a handle such that a user may pull the two structures together such that their respective plates either tenderize or slice food depending on the plates positioned thereto.
US08574038B2 Machining tool with secured replaceable tool elements
The invention concerns a rotating sanding/grinding/polishing tool (1) provided with a number of undercut mounting grooves (5) for mounting one or more displaceable grinding elements (4), at which is provided an annular groove (8) in a plane largely perpendicularly to the rotary axis of the tool, and a ring-shaped securing means (9) provided in the groove and a resilient means (11) along the periphery of the rotating tool (1), at which the securing means (9) has one side bearing against the resilient means (11) and another side bearing against part of the grinding elements (4).
US08574037B2 Multi-purpose extended reach tool
An apparatus adapted to be coupled to a power source having a rotary drive shaft is provided. The apparatus comprises an adapter, an extension pole, and a tool head. The adapter has a drive shaft and a fluid passage. A first end of the adapter drive shaft is adapted to be coupled to the power source drive shaft. The adapter fluid passage is adapted to receive fluid flowing from a source of fluid and to permit flow of fluid there through. The extension pole has a drive shaft and a fluid passage. A first end of the extension pole drive shaft is adapted to be coupled to a second end of the adapter drive shaft. The extension pole fluid passage is adapted to receive fluid flowing from the adapter and to permit flow of fluid there through. The tool head is adapted to be coupled to the extension pole.
US08574035B2 Polishing device with rotary joint
A polishing device for polishing optical lenses having a tiltable base part for directly or indirectly receiving a polishing plate, which base part is connected to a polishing spindle having an axis of rotation D in order to be rotationally driven, wherein a rotary joint for supplying a polishing agent is provided, which rotary joint is at least partly arranged opposite said polishing spindle, relative to the base part, and a coupling element is provided by means of which the rotary joint can be detachably push-fitted or clipped onto a polishing spindle. A method for polishing selected zones of aspherical lenses which are not rotationally symmetric using a polishing plate which is guided by a polishing spindle so as to be tiltable, wherein during polishing, a polishing agent is introduced between said polishing plate and the lens via a rotary joint arranged between said polishing spindle and said polishing plate.
US08574034B2 Cutting and edge-coating removal head to be mounted on cutting benches of sheets of glass
There is provided a cutting and edge-coating removal head for sheets of glass (V) coated by a film (S) to be mounted on cutting benches. The cutting tool (20) is positioned inside the edge-coating removal tool (10), consisting of a diamond-tipped disc, a cup grinder or spark grinder, a pad, a blade, or a brush with steel bristles.
US08574029B2 Orbital grinding aggregate
The invention concerns a grinding machine having displaceable grinding means for the processing of workpieces made from wood, wood composite materials, plastics, metals and similar materials. The invention further concerns a method of grinding a workpiece by means of the inventive grinding machine. The grinding aggregate comprises: at least one translational driving means configured to translate the grinding means (6) and at least one eccentric tappet configured to rotatingly move the grinding means (6). The inventive device is characterized in that the grinding aggregate comprises a suctioning device which suctions waste products of the processing, such as chips, through the grinding means. In this way, it is possible to achieve a qualitatively superior grinding result.
US08574026B2 Clothing article including a built-in bra
A clothing article such as a leotard has a built-in bra that is connected with the article only along an upper edge. The bra is thus free-floating and provides improved fit, comfort, support and appearance to the wearer, particularly during dance movements. The leotard has an open and low rear neckline and may include one or more decorative strap treatments. The bra includes front and rear wall portions which are connected with the leotard. An adjustable fastener is arranged between the front and rear wall portions of the bra which are free of the leotard so that the wearer can adjust the bra for proper fit.
US08574018B1 Tubular connection member with stamped threads on its exterior
A connection member includes a tube extending a length along a central longitudinal axis. The tube includes a central passageway that extends through the length of the tube. The tube has a non-circular cross-sectional shape along the length of the tube. The tube includes an exterior side that defines a perimeter of the non-circular cross-sectional shape of the tube. Stamped threads are formed on the exterior side of the tube along at least a portion of the length of the tube. The stamped threads are discontinuous along the perimeter of the non-circular cross-sectional shape of the tube such that the stamped threads only extend along at least one portion of the perimeter of the non-circular cross-sectional shape of the tube.
US08574017B2 Electrical contact with adjustable length
An electrical contact includes a primary segment having a primary outer end, and a secondary segment having a secondary outer end. An intermediate segment joins the primary and secondary segments together. The intermediate segment includes a primary segment connector engaged with the primary segment such that the intermediate segment is electrically and mechanically connected to the primary segment. The intermediate segment includes a secondary segment connector engaged with the secondary segment such that the intermediate segment is electrically and mechanically connected to the secondary segment. The electrical contact has a length defined from the primary outer end to the secondary outer end. At least one of the primary segment is selectively positionable relative to the primary segment connector of the intermediate segment or the secondary segment is selectively positionable relative to the secondary segment connector of the intermediate segment such that the length of the electrical contact is adjustable.
US08574012B2 Electrical connector with three ports and passthrough conductors for bicycle components
A bicycle including a frame, an electrical circuit including a power source, and an electrical connector. The electrical connector includes a first port defined by a first terminal that has a first configuration, and a second port defined by a second terminal that has a second configuration complementary to the first configuration. The electrical connector further includes a third port that is distinct from the first and second ports, a plurality of passthrough conductors extending from the first port to the second port to connect the electrical connector to the electrical circuit, and at least one lateral conductor providing an electrical connection from the first port to the third port.
US08573999B2 Plug-in connector as receptacle for a multi-wire cable
The invention pertains to a plug-connector for insertion of a multi-wire cable, wherein the wires are attached with the clamping-cutting technique. The plug-in connector exhibits a substrate and a plurality of clamping-cutting devices configured on the substrate and suitable for the insertion of wires. A first subset of the plurality of clamping-cutting devices is located on top of the substrate, while a second subset of the plurality of clamping-cutting devices is located at the bottom of the substrate. The plug-in connector furthermore exhibits wiring flaps suitable for the hinged insertion of the wires into the clamping-cutting devices.
US08573997B2 Multi-plugging connector system
A connector utilizes a latching assembly that has a structure that connects horizontal movement of an actuator to vertical movement of a latching arm. If desired, a 2X ganged plug can be inserted into any two adjacent bays of a ganged receptacle assembly that includes at least three bays.
US08573992B2 Connector system and method
An electrical connector for connecting to ground and first and second signal lines includes a ground contact, a first signal contact, a second signal contact, and a switch connected to the first signal contact and the ground contact. The switch is biased “on” until after the first signal contact is connected to the first signal line, the ground contact is connected to the ground, and the second signal contact is connected to the second signal line. The switch, during connection of the connector to ground and first and second signal lines, is thereby automatically triggered to “off” during connection of the connector. If the first and second signal lines are differential signals, the switch, instead, electrically connects and disconnects the first signal contact to the second signal contact.
US08573991B2 Lever connector
A lever connector includes a housing, and a lever rotatably provided on the housing to be rotated in a locking direction to be disposed at a connection locking position. The lever includes support plate portions rotatably supported by both sides of the housing, each support plate portion has a protrusion portion protruding toward a side of the housing, the both sides of the housing have groove portions with which the protrusion portions of the lever at the connection locking position are engaged, each groove portion has a tapered surface inclined in a protruding direction of a protrusion portion as extending in the locking direction of the lever, and as the protrusion portions are slid along the tapered surfaces to be engaged with the tapered surfaces, respectively, the lever is applied with a rotating force in the locking direction.
US08573990B2 Cover structure
A cover structure, adapted for mounting on a housing that is formed with an opening and a connection base having a plugging end exposing by the opening, comprising: a frame, formed with a first end and a second end that are arranged opposite to each other with respect to the radial of a coupling position where the frame is coupled to the housing through a pivot axis of two pivot blocks in a direction parallel to a first axis direction and enabling the first end to expose by the opening; and an elastic element, disposed inside the housing for providing an elastic force to the frame, for enabling the first end and the second end to move relative to each other centering the coupling position; wherein an accommodation space is formed between the frame and the connection base so as to be used for receiving a plug of a connector.
US08573988B2 Mounting structure of connector for circuit board
A mounting structure of a connector for a circuit board is provided. A circuit board is formed with a cutout, the cutout has a rectangular shape which is defined by three rectilinear side edges and one side edge is open, and one of the three side edge is a terminal arranging side edge part. Terminals are provided in the terminal arranging side edge part and are arranged along a longitudinal direction of the terminal arranging side edge part. A connector housing is formed with terminal containing grooves on a lower face thereof. The terminals are respectively contained in the terminal containing grooves when the connector housing is fitted into the cutout. By fitting the connector housing into the cutout, the terminals are contained in the terminal containing grooves, thereby to construct the connector for the circuit board in which the terminals are used as connector terminals.
US08573987B1 Power distribution box assembly
A power distribution box assembly having a power distribution box, a plurality of wire assemblies, a holder and a plurality of sets of resilient fingers. The power distribution box having a housing, which defines a plurality of terminal cavities, and a plurality of conductive busbars, each of which terminating at a busbar terminal that is received in a corresponding one of the terminal cavities. The wire assemblies are coupled to the busbar terminals and extending from a rear side of the housing. The holder is received in the rear side of the housing and engaged to the housing in a snap-fit manner. The holder has a plurality of wire channels, each of which receiving an associated one of the wires. Each set of resilient fingers has at least one finger that is resiliently coupled to the holder and configured to engage an associated one of the wires.
US08573976B2 Interactive method for helping the driver of a motor vehicle to adopt an economical driving style and vehicle using this method
The invention relates to an interactive driving assistance method. This method involves selecting a desired driving style, and analyzing (F1) a driver behavior during a detected life situation. From a memory (5), a recommended driver behavior is then selected for the current life situation corresponding to the desired driving style. The behavior of the driver is then compared (F1, 16) with the recommended behavior, and those aspects of the behavior which are considered to be improvable are identified. Finally an audio and/or video information message (7) is issued (F4, F5, 27) inviting the driver to correct his or her behavior on at least the most critical point.
US08573973B2 Disposable articulator having at least one continuous opening for acceptance of stabilization means
An articulator has trays which have at least one opening with repeating broadened and narrowed regions allows for varying stabilization means to be used therewith. In one embodiment, the stone used for making the model acts as a stabilizing means without use of pins.
US08573966B2 Combustion apparatus
To provide a combustion apparatus that has a vaporizer capable of vaporizing liquid fuel completely without complicating the structure of the combustion apparatus. The combustion apparatus has an evaporating part for heating and vaporizing the liquid fuel into combustion gas, and a premixed gas spout part for spouting out premixed gas in which the combustion gas is mixed with primary air, with an inflow port of the premixed gas spout part being provided at a position higher than the evaporating part. By configuring the combustion apparatus like this, a space for accumulating unvaporized liquid fuel is formed between the evaporating part and the inflow port, and sufficient time to completely vaporize the liquid fuel can be afforded. Therefore, unevaporated fuel in a liquid state can be prevented from flowing into the premixed gas spout part.
US08573964B2 Liquid or hydraulic blow molding
An apparatus and method for simultaneously forming and filling a plastic container is provided. A mold cavity defines an internal surface and is adapted to accept a preform. A pressure source is a servo motor system that includes an inlet. The servo motor system is operable to draw liquid through the inlet and urge it into the preform. A blow nozzle may be adapted to receive the liquid from the pressure source and transfer the liquid at high pressure into the preform thereby urging the preform to expand toward the internal surface of the mold cavity and create a resultant container. The liquid remains within the container as an end product.
US08573960B2 Mold assembly with interchangeable insert for blow-molding
A blow-molding mold assembly comprising: a base mold cavity located within the mold-holder of a molding machine, characterized in that the assembly includes an interchangeable insert located within the base mold cavity; the base mold cavity having in its left side a gliding locking means and in its right side having fixed locking means, and the interchangeable insert having in its left and right sides grooves to receive the locking means corresponding to each side of the base mold cavity to avoid rotational movement of the interchangeable insert, the interchangeable insert having further an exterior edge to be housed in an interior recess of the base mold cavity to avoid longitudinal movement of the interchangeable insert.
US08573958B2 Improvements for rapid prototyping apparatus
A stereolithography apparatus and an exposure system for a stereolithography apparatus, wherein light emitting diodes are used as light sources. The invention relates to aligning light from the light emitting diode and to the exchange and control of the light emitting diodes.
US08573953B2 Oil pump mounting structure
A mounting structure for mounting a separate shaft type oil pump in a case of a transmission. The separate shaft type oil pump is driven by a shaft that is separate from and rotated in cooperation with a shaft arranged in a torque input route extending from an engine to the transmission to supply hydraulic oil to a transmission oil pressure control mechanism. The mounting structure includes a spacer coupler that fastens the oil pump to the transmission case. The spacer coupler includes a plurality of spacers that couple the oil pump and the transmission case. An oil passage is formed in the spacers of the spacer coupler to connect an oil pressure system, which includes the oil pressure control mechanism, and the oil pump. A manual shaft for operating the transmission is arranged in a clearance between the spacers of the spacer coupler.
US08573952B2 Priming protection
Embodiments of the invention provide a pumping system for at least one aquatic application. The pumping system includes a pump, a motor coupled to the pump, and a controller in communication with the motor. The controller determines an actual power consumption of the motor and compares the actual power consumption to a reference power consumption. The controller also determines that the pump is in an unprimed condition if the actual power consumption is less than the reference power consumption and that the pump is in a primed condition if the actual power consumption is at least equal to the reference power consumption.
US08573949B2 Method and system for focused energy brazing
A method and system that includes generation of an energy beam. The energy beam may be generated from a focused energy source. Additionally, the energy beam may be directed towards a pre-sintered preform. The pre-sintered preform may be made of a braze material and may seal a hole that may be located in a turbine component.
US08573948B2 Airfoil
An airfoil has a hollow shell providing external airfoil surfaces, and a corrugated core within the shell. The core contacts inner surfaces of the shell to support the shell. The airfoil is formed by consolidating a hollow shell pre-form and a corrugated core pre-form. At least a part of the hollow shell has a leading edge shell portion and/or a trailing edge shell portion which, before consolidation of the pre-forms, is a unitary body having a shape which wraps around the respective edge.
US08573945B2 Compressor stator vane
A compressor component having a non-linear thickness distribution along the span length is disclosed. By altering the thickness distribution to a non-linear arrangement so as to locally increase airfoil thickness proximate a mid-span location, the natural frequency of the airfoil is increased so as to not coincide with a critical engine order of the compressor. Further, the present invention provides a novel airfoil profile in accordance with the coordinates of Table 1. The present invention also includes a carrier segment or disk fabricated from a material so as to eliminate corrosion with the compressor component.
US08573940B2 Interlocking knife edge seals
A compressor for a turbine engine includes multiple compressor disks having rotor blades mounted about the circumference of each of the disks. A plurality of stator blades extend between the rotor blades of axially adjacent disks. A knife edge seal is supported and retained by retaining flanges extending from a rim on each disk, and contacts the stator blades to limit the recirculation of air within the compressor. A plurality of lock assemblies are spaced about the circumference of disk backbones formed in each disk, with a plurality of knife edge seals located between each lock assembly. When in the lock position the lock assemblies reduce the slack used for assembly of the final knife edge seal to prevent shifting and rotating during operation.
US08573936B2 Blade for turbomachine receiving part, comprising an airfoil part including a mechanical fuse
A blade for an aircraft turbomachine receiving part including a root, and an airfoil part prolonging this root. The airfoil part includes a mechanical fuse located at a distance from the bottom of the blade, along the length direction of the airfoil part, between 0.25 and 0.5 times the length of the airfoil part along this length direction.
US08573935B2 Helicopter rotor comprising a vibration damper, and method for updating the same
A rotor for a helicopter, having: a hub rotating about an axis and in turn having a number of blades; and an at least partly hollow drive shaft connectable to a drive of the helicopter and connected functionally to the hub to rotate the hub about the axis; the rotor also having vibration damping means in turn having a mass, and an elastically deformable member connected to the mass and supported by the shaft; the member extending at least partly inside the shaft, and being elongated parallel to the axis; and the mass vibrating, in use, at such a frequency as to oppose transmission to the shaft of the vibration produced by rotation of the hub and blades.
US08573927B2 Back-up featherer
A back-up featherer for an engine arrangement having a main hydraulic actuator which angularly displaces propellers of a propeller assembly of the engine arrangement, and fluid supply lines for transferring hydraulic fluid between a hydraulic pressure power source located on a static structure of the engine arrangement and the main hydraulic actuator. The back-up featherer has a back-up actuator assembly for angular displacement of the propellers, the back-up actuator assembly rotating with the propeller assembly, a signal detector operatively connected to the back-up actuator assembly and rotates with the propeller assembly, and a back-up rotating coupling. A static side of the back-up rotating coupling is mounted to the static structure of the engine arrangement and communicates with a regulator located on a static structure of the engine arrangement. A rotating side of the back-up hydraulic rotating coupling rotates with the propeller assembly and communicates with the signal detector.
US08573926B2 Gas turbine engine fan drive gear system damper
A gas turbine engine includes a fan section. A turbine section is coupled to the fan section via a geared architecture. The geared architecture includes a torque frame and a flex support spaced apart from one another at a location. A gear train is supported by the torque frame. A damper is provided between the torque frame and the flex support at the location.
US08573924B2 Gas compressor
A gas compressor a rotor shaft and is arranged such that gas flow to an impeller stage is via a bore in the rotor shaft; and/or impeller stages are arranged in series such that flow into respective stages is in respectively opposed directions. The compressor most effectively functions with the rotor shaft arranged in a substantially upright orientation and beneficially has conical mounting bearing.
US08573923B2 Cooled aerofoil for a gas turbine engine
A cooled aerofoil for a gas turbine engine has an aerofoil section with pressure and suction surfaces extending between inboard and outboard ends thereof. The aerofoil section includes first and second internal passages for carrying cooling air. The aerofoil section further includes a plurality of holes in the external surface of the aerofoil section which receive cooling air from the internal passages. The external holes are arranged such that cooling air exiting a first portion of the external holes participates in a cooling film extending from the leading edge of the aerofoil section over said pressure surface and cooling air exiting from a second portion of the external holes participates in a cooling film extending from the leading edge over said suction surface. The first portion of external holes receives cooling air from the first internal passage, and the second portion of external holes receives cooling air from the second internal passage. The first and second internal passages are supplied with cooling air from respective and separate passage entrances. Each entrance is located at either the inboard end or the outboard end of the aerofoil section.
US08573917B2 Bulk seed handling system
A bulk seed handling system (20) is provided to facilitate seed transfer from a distributor to a farm and then to a planter or the like. The handling system (20) includes one or more upright bin assemblies (22) adapted to be moved in a filled condition, and a trailer (24) designed to move the bin assembly (22) and unload seed therefrom. The bin assembly (22) includes a seed bin (26) having a lower unload opening (34) and supported by a frame assembly (38) including telescopic legs (50) shiftable between a retractable travel position and an extended bin support position. The trailer (24) includes a lift frame (60) operable to engage and elevate the bin assembly (22) for travel with the legs (50) thereof in a retracted position, and a seed-conveying arrangement including an intermediate conveyor (62) and a delivery conveyor (64). At an unloading site, the intermediate conveyor (62) is shifted to an unloading position in communication with the bin unload opening (34) and the delivery conveyor (64) in order to transfer seed from the bin.
US08573915B2 Trailer
A trailer for transporting large equipment, buses, recreational vehicles, wherein the trailer includes a main deck at its forward end which is supported upon first and second elongated frame members. First and second running gear beams extend rearwardly from the rearward ends of the first and second frame members with each of the running gear beams including an upwardly and rearwardly extending first beam portion, a rearwardly and horizontally extending second beam portion and a downwardly and rearwardly extending third beam portion. First and second ramps are positioned laterally outwardly of the third beam portions of the first and second running gear beams and are movable between upper and lower positions. Vertically movable bolsters are positioned between the wheels of the axles which support the trailer at the rearward end thereof. The bolsters may be moved from a lower transport position to an upper loading/unloading position.
US08573913B2 Wall mounted toggle hook
A convertible anchor (H) for friable walls (W) comprises a fixture (12) for holding an article to a wall (W, M) and an anchoring mechanism (10) extending from the fixture (12). The anchoring mechanism (10) is adapted when rotated to engagingly extend into a friable wall (W) for securing the fixture (12) to the wail (W). The fixture (12) is selectively separable via frangible connection elements (14, 24) from the anchoring mechanism (10) for allowing the fixture (12) to be used alone with an appropriate fastener (S) suitable for installing the fixture (12) to a rigid structure (M), such as wooden components. The anchoring mechanism (10) can take different forms as long as it is can be mounted to a friable wall (W). Typically, a space (26) is defined between the fixture (12) and a proximal end (34) of the anchoring mechanism (10) with this space (26) being bridged by the frangible connection elements (14, 24). The fixture (12) defines an opening (16) adapted to be engaged by a screwdriver bit (B) for mounting the anchor (H) to the wall (W, M). The method calls for determining the nature of the vertical support to which the anchor (H) is to be mounted and then, for a friable wall (W), installing the anchor (H) thereto using the anchoring mechanism (10); or, for a more solid vertical support (M) such a wood, separating the fixture (12) from the anchoring mechanism (10) and installing the fixture (12) to the solid vertical support (M) via an appropriate fastener (S).
US08573912B2 Fastener for attaching a milling cutter body to an adaptor and method of installing same
A fastener for attaching a milling cutter body to an adaptor includes a head portion, a body portion and an undercut disposed between the head portion and the body portion. The head portion has a diameter greater than a diameter of the undercut and a thread root diameter. The diameter of the undercut is equal to or less than the thread root diameter to allow the fastener to freely rotate when the fastener is threaded completely through the milling cutter body. Once threaded completely threaded the milling cutter body, the fastener is threaded into the adaptor to securely attached the milling cutter body to the adaptor.
US08573910B2 High performance sleeved interference fasteners for composite applications
A fastener adapted to pass through aligned holes through workpieces is disclosed. The fastener includes a pin member having a transition portion wherein the diameter of the transition portion decreases radially as it extends from the smooth cylindrical shank portion to the threaded portion. The fastener may also comprise a sleeve member and a clamping means. The clamping means includes a collar, a nut, or any other possible clamping means. In exemplary embodiments, the workpieces can be formed with a plurality of materials, the materials including composite, metallic, or composite/metallic structures, any combination thereof. In particular embodiments, the fastener has interference capability of 0.0005 to 0.0100 inches in composite structures without risk of composite delamination or damage. As a result of the fastener interference, gaps between the fastener and the structure are eliminated thereby providing good electrical conductivity between components. As a result, the potential for electrical sparks is reduced, providing a safer fastener for use with aerospace applications.
US08573909B2 Tool coupling
In a tool coupling in the form of a cutting tool used for internal machining operations, a second component having a single cutting portion is clamped to a first component by means of a clamping screw. The second component has a mounted surface with three male engaging members interfacing with three female engagement members on a mounting surface of the first component. Each of the three female engagement members has two sets of side surfaces located on a shared portion, the shared portion exhibiting mirror symmetry about a first plane, and each set of side surfaces having two opposing flank surfaces separated by the first plane. Only one of the two flank surfaces of each of the two sets of side surfaces is in clamping contact with a corresponding abutment surface on each of the three male engaging members.
US08573901B2 Assembly for rotating a cutting insert during a turning operation and inserts used therein
A cutting insert rotated about its axis may be utilized during a metalworking operation and applied against the rotating workpiece to enhance tool performance. The cutting insert is secured within a toolholder having features to secure the insert but at the same time make for efficient removal of the insert from the toolholder.
US08573895B2 Unloading plant for low-lying storage bunkers
An apparatus includes a feed chamber for feeding of material from storage bunkers and a lifting device for lifting the material to a high level. The lifting device includes a delivery end to which a transport line for conveying the material away to a remote delivery point can be connected, a pressure vessel having a vertical conveyor that begins in the feed chamber and ends in a top region of the pressure vessel, and a discharge pipe beginning in a bottom region of the pressure vessel and leading out of the pressure vessel. The apparatus also includes a pressurizing device which pressurizes the pressure vessel via a first valve and activates a conveying air nozzle of the discharge pipe via a second valve, and a controller for filling the pressure vessel via the vertical conveyor, fluidizing the material via the pressurizing device, and conveying the material away via the transport line.
US08573894B2 Connection device for a reinforced earth structure and related structure and method
Link device (100) between a facing element (20) of a reinforced ground construction work (1) and a longitudinal reinforcement (40), intended to extend in a backfill (60), which comprises a portion (101) for fixing to the facing element (20), two connecting portions (102), of which a first end of each of them is linked to a point of the fixing portion (101), in which a second end of each connecting portion is linked to a first end of a first and of a second return portion (103), in which the return portions (103) are substantially parallel to one another and in which a second end of each of the return portions is linked to a securing segment (104) substantially perpendicular to the return portions (103).
US08573892B2 Method of providing a support column
A primary earth penetrating mandrel formed of a hollow shell steel plate octagonal in cross-section has an upper end and a blunt lower end joined by an upwardly and outwardly tapered wall. The mandrel is driven downwardly in the earth to simultaneously form a vertical tapered cavity while compacting the sidewall of the cavity to provide structural integrity. The mandrel is then moved upwardly from the bottom of the cavity and aggregate is deposited in the bottom of the cavity following which the mandrel is lowered so that its blunt lower end engages the deposited aggregate and densifies the aggregate by vertical vibratory action and static force with these steps being repeated until the pier top is near the surface of the earth at which time the upper aggregate portions are densified by either the primary mandrel or a secondary mandrel having a substantially larger lower end surface than the lower end surface of the primary mandrel. A second embodiment includes a conduit in the primary mandrel for injecting concrete or grout into aggregate previously deposited in the cavity.
US08573891B2 Tension buoyant tower
An offshore structure comprises a base configured to be secured to the sea floor. In addition, the offshore structure comprises an elongate stem having a longitudinal axis, a first end distal the base and a second end pivotally coupled to the base. Further, the offshore structure comprises an upper module coupled to the first end of the stem. The upper module includes a variable ballast chamber. Still further, the offshore structure comprises a first ballast control conduit in fluid communication with the variable ballast chamber of the upper module. The first ballast control conduit is configured to supply a gas to the variable ballast chamber of the upper module and vent the gas from the variable ballast chamber of the upper module. Moreover, the offshore structure comprises a deck mounted to the upper module.
US08573890B2 Marine power generator deployment and retrieval system
An offshore structure for deploying and retrieving underwater electrical power generators that converts energy derived from water currents into electrical energy. The offshore structural platform includes a pair of vertical guide rails to guide a propulsion device lowering said generator underwater onto a seabed propulsion device. The seabed propulsion device is engaged on an underwater seabed rail system and transports the generator onto one of many unique frames specifically designed to support underwater generators. Securing devices are utilized to ensure the generators remain anchored to each propulsion device and to the unique frame. Rail transferring elements are also utilized for a smooth and safe transition during the transport process.
US08573888B2 Method and apparatus for mounting distributed buoyancy modules on a rigid pipeline
An apparatus and method for mounting a buoyancy module onto a rigid pipe having a clamp. In one embodiment the clamp includes pads for clamping onto the outer surface or coating of the rigid pip, the pads having a teeth or serrations formed thereon for gripping the outer surface of the pipe. In a second embodiment, the clamp includes one or more coil springs formed from a resilient material adapted to be wound around the outer circumference of the pipe. The method for mounting a buoyancy module onto a rigid pipe includes the steps of reducing the outer diameter of the pipe at a location of the pipe to which a buoyancy module is to be attached and subsequently mounting a buoyancy module at such location.