Document Document Title
US08530756B1 Electromagnetically shielded enclosure and entry seal
An electromagnetically shielded enclosure that is portable and lightweight that can be used for applications such as testing and security. The electromagnetically shielded enclosure has a novel entry seal that eliminates the electromagnetic leakage that is common around the entry areas of such enclosures. The entry seal has an outer door with a perimeter magnetic material, an outer door magnetic closure that aligns with the outer door perimeter magnetic material, an inner door with a perimeter magnetic material, and an inner door magnetic closure that aligns with the inner door perimeter magnetic material.
US08530755B2 Wiring board and method for manufacturing the same
A wiring board including a core insulation layer having a connection conductor formed in a hole of the core layer, and an interlayer insulation layer laminated on one side of the core layer. The conductor of the core layer includes plating filling the hole of the core layer. The interlayer layer has a connection conductor formed in a hole of the interlayer layer. The conductor of the interlayer layer includes plating filling the hole of the interlayer layer. The conductor of the interlayer layer is stacked on the conductor of the core insulation layer. The conductors of the core and interlayer layers have lands formed on the core and interlayer layers and including metal foils and plating on the foils. The foil of the land on the core layer has a thickness which is thicker than a thickness of the foil of the land on the interlayer layer.
US08530753B2 Fine wiring package and method of manufacturing the same
At least one electronic component having a plurality of terminals on one of surfaces is temporarily fixed to a surface of a first support with a first adhesive layer in such a manner that the terminal side of the electronic component faces the first support. A second support having a second adhesive layer is fixed to the electronic component in order to interpose the electronic component between the first support and the second support. The first support and the first adhesive layer are peeled. The electronic component on the second support is sealed with a sealing resin in such a manner that at least a part of the terminals of the electronic component is exposed. An insulating resin layer and a wiring layer to be electrically connected to the terminal of the electronic component are stacked on the electronic component and the sealing resin.
US08530749B2 Copper foil attached to the carrier foil, a method for preparing the same and printed circuit board using the same
Provided is an ultra-thin copper foil to which a carrier foil is attached, including: a carrier foil, a peeling layer, and an ultra-thin copper foil, wherein the peeling layer includes a first metal A having peelability, a second metal B and a third metal C facilitating coating of the first metal, wherein the amount (a) of the first metal A is in a range of about 30 to about 89% by total weight of the peeling layer, the amount (b) of the second metal B is in a range of about 10 to about 60% by total weight of the peeling layer, and the amount (c) of the third metal C is in a range of about 1 to about 20% by total weight of the peeling layer.
US08530744B2 Rail wiring duct
A DIN rail wiring duct has a top, a bottom, and a side. The DIN rail wiring duct includes a base. The base has a top wall, a bottom wall, a sidewall, and a divider wall, which define a channel and a channel opening for accessing the channel. The DIN rail wiring duct also includes a cover for the channel opening. The cover has a top wall and a sidewall substantially perpendicular to the top wall. The top wall of the cover is removably connected to the top wall of the base and the sidewall of the cover is rotatably connected to the sidewall of the base such that the channels are accessible through the channel openings from the top and the side of the DIN rail wiring duct when the cover is rotated from a closed position to an open position.
US08530741B2 Micro coaxial cable and laser beam shielding resin composition
An micro coaxial cable which includes: a center conductor that enables transfer of a signal; an insulator that covers a periphery of the center conductor; an external conductor as a shield that covers a periphery of the insulator; and a jacket that covers a periphery of the external conductor, in which the insulator is formed of a resin composition containing insulating resin, carbon black and fired pigment, and the fired pigment contains titanium (Ti), antimony (Sb) and chromium (Cr).
US08530740B2 Luminescent object and utilization thereof
A first aspect of the invention relates to a luminescent object comprising: a. a luminescent layer or core containing a photoluminescent material; and b. a wavelength-selective mirror; wherein the luminescent layer or luminescent core is optically coupled to the wavelength-selective mirror, said wavelength-selective mirror being at least 50% transparent to light absorbed by the photoluminescent material and at least 50% reflective to radiation that is emitted by the photoluminescent material. The luminescent object according to the present invention may advantageously be employed in luminescent solar concentrator systems as it enables highly efficient transportation of radiation emitted by the photoluminescent material following exposure to incident solar light. Another aspect of the invention concerns a photovoltaic device comprising an electromagnetic radiation collection medium containing the aforementioned luminescent object and a photovoltaic cell capable of converting optical radiation to electrical energy which is optically coupled to the luminescent object. Further aspects of the invention include a fluorescent light activated display and a room lighting system comprising the aforementioned luminescent object.
US08530739B2 Nanowire multijunction solar cell
A solar cell includes a substrate layer and a plurality of nanowires grown outwardly from the substrate layer, at least two of the nanowires including a plurality of sub-cells. The solar cell also includes one or more light guiding layers formed of a transparent, light scattering material and filling the area between the plurality of nanowires.
US08530737B2 Arrangement for securing elongated solar cells
A solar panel apparatus includes a set of photovoltaic modules. The modules are configured to photovoltaically generate electricity from light. Each module is elongated along an axis and has first and second axially opposite ends. An end rail has a groove into which the first end of each module is potted in place with potting material.
US08530736B2 Musical tone signal synthesis method, program and musical tone signal synthesis apparatus
A musical tone signal is synthesized based on performance information to simulate a sound generated from a musical instrument having a string and a body that supports the string by a support. There is provided a closed loop circuit having a delay element that simulates delay characteristic of vibration propagated through the string and a characteristic control element that simulates a variation in amplitude or frequency. A string model calculation circuit inputs an excitation signal based on the performance information to the closed loop circuit, and calculates first information representing a force of the string acting on the support based on a cyclic signal generated in the closed loop and representing the vibration of the string circuit. A body model calculation circuit calculates second information representing a displacement of the body or a derivative of the displacement. A musical tone signal calculation circuit calculates the musical tone signal.
US08530734B2 Device and method for rhythm training
A programmable rhythm trainer configured to operate on a general purpose computing device including a handheld computing device or a mobile communication device. According to an embodiment, the programmable rhythm trainer comprises a component configured to generate a mix or chain comprising one or more bars and each the bars comprising one or more note arrangements. According to an embodiment, the programmable rhythm trainer comprises a component configured to rearrange one or more of the bars in the chain and save the rearranged chain to memory. According to an embodiment, the programmable rhythm trainer comprises a component configured to rearrange one or more of the note arrangements belonging to one of the bars. According to an embodiment, the programmable rhythm trainer comprises a component configured to set a beats-per-minute for one or more the chains in response to a user input. According to an embodiment, the programmable rhythm trainer comprises a graphical user interface and input for manipulating one or more of the notes, the note arrangements, the bars and/or the chains or mixes. According to an embodiment, the programmable rhythm trainer comprises an application or software program configured to run on computing device. According to another embodiment, the programmable rhythm trainer comprises a portable or handheld device.
US08530733B2 Musical instrument support apparatus
A height adjustable music instrument support structure is used to secure a musical instrument while in a sitting position. A top is connected to base component using a nut and bolt mechanism. The height adjustment is lockable using a knob on the nut that latches to one of the notches on the bolt. The top is lined using soft material to prevent scratching of the musical instrument. The base is padded to enable comfortable user positioning.
US08530732B2 Hammer device for electronic keyboard instrument
A hammer device for an electronic keyboard instrument, enabling prevention of grease or the like from adhering to an actuator portion during mounting of the hammer, to thereby enable speedy hammer mounting work and improve the work efficiency. The hammer device includes a hammer support and hammers arranged side by side in a left-right direction and each pivotally supported by the hammer support to pivotally move in accordance with depression of an associated key. When mounting the hammer to the hammer support, before a shaft hole is engaged with a fulcrum shaft portion, left and right protrusions of the hammer are brought into abutment with respective left and right stopper walls provided close to the respective left and right ends of the fulcrum shaft portion, to thereby prevent the actuator portion from being brought into contact with the fulcrum shaft portion.
US08530730B1 Hybrid corn variety 980007
The invention provides seed and plants of the hybrid corn variety designated 980007. The invention thus relates to the plants, seeds and tissue cultures of the variety 980007, and to methods for producing a corn plant produced by crossing a corn plant of variety 980007 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety 980007.
US08530728B1 Inbred corn line NPDC5592
Basically, this invention provides for an inbred corn line designated NPDC5592, methods for producing a corn plant by crossing plants of the inbred line NPDC5592, with plants of another corn plant. The invention relates to the various parts of inbred NPDC5592, including culturable cells. This invention also relates to methods for introducing transgenic transgenes into inbred corn line NPDC5592, and plants produced by said methods.
US08530726B2 Canola cultivar G030994
The present invention relates to a new and distinctive canola cultivar, designated G030994. Also included are seeds of canola cultivar G030994, to the plants, or plant parts, of canola G030994 and to methods for producing a canola plant produced by crossing the canola G030994 with itself or another canola cultivar, and the creation of variants by mutagenesis or transformation of canola G030994.
US08530723B2 Markers associated with resistance to Aphis glycines and methods of use therefor
Methods for conveying Aphis glycines resistance (RAG) into non-resistant soybean germplasm are provided. In some embodiments, the methods include introgressing RAG into a non-resistant soybean using one or more nucleic acid markers for marker-assisted breeding among soybean lines to be used in a soybean breeding program, wherein the markers are linked to and/or associated with RAG. Also provided are single nucleotide polymorphisms (SNPs) associated with resistance to Aphis glycines; soybean plants, seeds, and tissue cultures produced by any of the disclosed methods; seed produced by the disclosed soybean plants; and compositions including amplification primer pairs capable of initiating DNA polymerization by a DNA polymerase on soybean nucleic acid templates to generate soybean marker amplicons.
US08530722B2 Disposable diaper having nonwoven topsheet with particular combination of basis weight and bonding configuration
A disposable diaper is disclosed. The diaper includes a colored topsheet. The topsheet has a basis weight of from 12 to 18 gsm and comprises a plurality of bonded points. Each of the bonded points has a surface area of from 2 mm2 to 5 mm2 and the cumulated surface area of the plurality of bonded points is from 10 to 25% of the total surface area of the topsheet.
US08530718B2 Mitigation of secondary phase formation during waste vitrification
A method for vitrification of high level waste to reduce the formation of persistent secondary phases comprising the steps of providing a high level waste for vitrification; providing a glass frit additive for mixing with said high level waste; redistributing selected constituents of said glass frit for mixing separately as raw chemicals with said high level waste; and, feeding said high level waste, said glass frit additive, and the redistributed glass frit constituents to a melter for vitrification of said high level waste so that formation of secondary phases is suppressed.
US08530714B2 Method for production of lower olefin
Disclosed is a method for production of lower olefins from a raw material containing dimethyl ether (DME), which can produce lower olefins (e.g. propylene) with good yield and in an economically advantageous manner by prolonging the time until the reversible deactivation of a zeolite catalyst and preventing the irreversible deactivation of the catalyst, can reduce the amount of water to be recycled to increase the thermal efficiency of the process, and can simplify the facilities and operations. Also disclosed is a method for improving the yield of propylene with good efficiency under practical operating conditions. A feed gas which comprises a DME-containing feedstock gas and an additive gas and further contains steam at a specific proportion is introduced into an olefin synthesis reactor to contact the feed gas with a zeolite catalyst, thereby producing a hydrocarbon product containing C2-C5 olefins. Propylene or the like is separated/collected from the hydrocarbon product, and at least a part of the remainder is used as at least a part of the additive gas.
US08530705B2 Purification method of dihydroxybenzene
A purification method of dihydroxybenzene comprising the following steps, for obtaining purified dihydroxybenzene from crude dihydroxybenzene containing at least isopropenylphenol and hydroxyacetophenone as impurities: first extraction step, distillation step, second extraction step, and recovery step.
US08530700B2 Process for producing acrylic acid
The process for the distillation of a gas mixture comprising (meth)acrylic acid obtained from the gas-phase oxidation of at least one (meth)acrylic acid precursors is improved through the use of coupled distillation columns. In a first column, the gaseous mixture is dehydrated while in a second column, the dehydrated gaseous mixture is distilled into product, overhead and bottoms streams.
US08530698B2 Packing material for liquid chromatography and process for separation and purification of biopolymer by means of the packing material
A packing material for liquid chromatography capable of separating and purifying, or collecting and recovering, a biopolymer such as a protein or a peptide by adsorption and desorption by a pH change without being influenced by the isoelectric point of the protein or by the salt concentration in a solvent in which the biopolymer such as the protein is dissolved. Separation and purification, or collection and recovery, of a biopolymer, is carried out by liquid chromatography by means of a packing material for liquid chromatography comprising a base matrix and a ligand immobilized to the base matrix, wherein the base matrix is a hydrophilic base matrix having alcoholic hydroxy groups on its surface, the ligand is at least one ligand selected from the group consisting of an α-amino acid which is immobilized to the base matrix by an amide bond or an urethane bond via the amino group contained in the α-amino acid.
US08530691B2 Process for the preparation of fesoterodine
A process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine), its (S)-enantiomer, and novel intermediates useful in the synthesis.
US08530688B2 Method for preparing exo-tricyclo[4.2.1.02,5]non-7-ene-3-spiro-1′-(3′-ethyl-3′-alumina)cyclopentane
The invention relates to the field of organic synthesis, more specifically to a method for preparing novel organo-aluminum compounds. The compound in question can be used as a component in catalytic systems in processes for the oligomerization and polymerization of olefin, diene and acetylene hydrocarbons as well as in fine organic and organometallic synthesis. The essence of the method consists in reacting 3-methylene-exo-tricyclo[4.2.1.02,5]non-7-ene with triethylaluminium in the presence of the catalyst zirconocene dichloride in an inert gas atmosphere, preferably in argon or nitrogen, at room temperature, in an aliphatic or aromatic solvent for 5-7 h.
US08530682B2 Process for epoxidation start-up
A method for the start-up of a process for the epoxidation of ethylene comprising: initiating an epoxidation reaction by reacting a feed gas composition containing ethylene, and oxygen, in the presence of an epoxidation catalyst at a temperature of about 180° C. to about 210° C.; adding to the feed gas composition about 0.05 ppm to about 2 ppm of moderator; increasing the first temperature to a second temperature of about 240° C. to about 250° C., over a time period of about 12 hours to about 60 hours; and maintaining the second temperature for a time period of about 50 hours to about 150 hours.
US08530678B2 Trioxane production method wherein a side aqueous flow is deducted at a first distillation stage
Processes are disclosed comprising: (a) reacting an aqueous formaldehyde solution in a reactor in the presence of a suitable catalyst to obtain a reaction product mixture comprising trioxane, formaldehyde and water; (b) distilling the reaction product mixture to form a top stream comprising crude trioxane; and (c) treating the top stream in one or more additional stages to form pure trioxane; wherein an aqueous sidestream is drawn off during the distilling of the reaction mixture.
US08530677B2 Substituted 3-hydroxy-delta-lactones from epoxides
Catalysts and methods for the carbonylation of epoxides to substituted 3-hydroxy-δ-lactones and β-lactones are disclosed.
US08530674B2 Process for preparing (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine by using optically active methylhydroxylaminopropanol compound as intermediate
The present invention provides (S)-methylhydroxylaminopropanol compound as an intermediate in preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine. The present invention also provides a process for preparing (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with higher yield and lower cost by using the (S)-methylhydroxylaminopropanol compound as an intermediate.
US08530672B2 Organic compound, anthracene derivative, and light-emitting element, light-emitting device, and electronic device using anthracene derivative
Objects of the present invention are to provide novel anthracene derivatives and novel organic compounds; a light-emitting element that has high emission efficiency; a light-emitting element that is capable of emitting blue light with high luminous efficiency; a light-emitting element that is capable of operation for a long time; and a light-emitting device and an electronic device that have lower power consumption. An anthracene derivative represented by a general formula (1) and an organic compound represented by a general formula (17) are provided. A light-emitting element that has high emission efficiency can be obtained by use of the anthracene derivative represented by the general formula (1). Further, a light-emitting element that has a long life can be obtained by use of the anthracene derivative represented by the general formula (1).
US08530670B2 Inhibitors
Novel heterocyclic derivatives of formula (I): or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein Ra, n, R1 and R2 are as defined herein, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5).
US08530669B2 Ester compound and use thereof
An ester compound represented by formula (1): wherein R1 represents C1-C4 alkyl, has an excellent pest control effect and is therefore useful as an active ingredient of a pest control agent.
US08530665B2 Crystalline (R)-(E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol
The present invention provides crystalline (R)-(E)-2-(4-(2-(5-(1-(3,5 -dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol useful in the treatment of cancer.
US08530662B2 Pyridyltetrahydropyridines and pyridylpiperidines, and method of manufacturing them
The present invention provides pyridine derivatives useful as intermediates of drugs and agricultural chemicals, electrophotographic receptors, dyes and so on. More specifically, the invention relates to novel pyridyltetrahydropyridines and novel pyridylpiperidines, and further to a method of manufacturing pyridine derivatives through reaction between bipyridine derivatives and benzyl halide or benzyloxycarbonyl halide and subsequent reduction of the resultant reaction products with the aid of palladium catalysts, platinum catalysts, ruthenium catalysts or rhodium catalysts.
US08530659B2 Pharmaceutical composition containing cyclometalated N-heterocyclic carbene complexes for cancer treatment
The present disclosure is related to a pharmaceutical composition for treatment of cancer comprising a cyclometalated N-heterocyclic carbene complex. The cyclometalated N-heterocyclic carbene complex contains a gold(III) or a platinum(II) atom. The pharmaceutical composition possesses anti-cancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of topoisomerase and/or poisoning of topoisomerase.
US08530658B2 Carbazole derivative with heteroaromatic ring, and light-emitting element, light-emitting device, and electronic device using carbazole derivative with heteroaromatic ring
Disclosed is a carbazole derivative and a light-emitting element, a light-emitting device, and an electronic device using thereof. The carbazole derivative possesses an oxadiazole moiety or a quinoxaline moiety as a heteroaromatic ring having an electron-transporting property and a carbazole moiety having a hole-transporting property. The ability of the carbazole derivative to transport both electrons and holes and its large excitation energy larger than a triplet excitation energy of a phosphorescent compound allow the formation of a phosphorescent light-emitting element having well-controlled carrier balance, which contributes to the formation of light-emitting devices and electronic devices that are capable of being driven at a low voltage, have a long lifetime, and consume low power. The detailed structure of the carbazole derivative is defined in the specification.
US08530657B2 Substituted adamantanes and their therapeutic application
The present invention relates to tetrahydroquinoxaline urea derivatives of formula (I) as defined herein, and, to their preparation and to their therapeutic application.
US08530655B2 HIV replication inhibiting pyrimidines
This invention concerns the use of compounds of formula the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein -a1=a2-a3=a4- forms a phenyl, pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl with the attached vinyl group; n is 0 to 4; and where possible 5; R1 is hydrogen, aryl, formyl, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl, substituted C1-6alkyl, or substituted C1-6alkyloxyC1-6alkylcarbonyl; each R2 independently is hydroxy, halo, optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl, C3-7cycloalkyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkylamino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)pR6, —NH—S(═O)pR6, —C(═O)R6, —NHC(═O)H, —C(═O)NHNH2, —NHC(═O)R6, —C(═NH)R6 or a 5-membered heterocyclic ring; p is 1 or 2; L is optionally substituted C1-10alkyl, C2-10alkenyl, C2-10alkynyl or C3-7cycloalkyl; or L is —X—R3 wherein R3 is optionally substituted phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl; X is —NR1—, —NH—NH—, —N═N—, —O—, —C(═O)—, —CHOH—, —S—, —S(═O)— or —S(═O)2—; Q is hydrogen, C1-6alkyl, halo, polyhalo-C1-6alkyl or an optionally substituted amino group; Y represents hydroxy, halo, C3-7cycloalkyl, optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)pR6, —NH—S(═O)pR6, —C(═O)R6, —NHC(═O)H, —C(═O)NHNH2, —NHC(═O)R6, —C(═NH)R6 or aryl; aryl is optionally substituted phenyl; Het is an optionally substituted heterocyclic radical; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection.
US08530653B2 Enzyme inhibiting compounds
The present invention is directed to compounds that are specifically structured to provide enzyme inhibition. In specific embodiments, the enzyme inhibiting compounds exhibit antifolate activity. Particularly, the inventive compounds are formed of an antifolate residue that is active in inhibiting one or more of TS, DHFR, GAR, FPGS, and AICAR Tfase. The enzyme inhibiting compounds are useful in a variety of methods of treatment, including treating abnormal cell proliferation and treating inflammation.
US08530652B2 Pyrrolopyrazoles, potent kinase inhibitors
Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
US08530649B2 Polymer complex
A polymer complex having two or more kinds of channel groups through which specific compounds ranging from gaseous small molecules to large molecules such as proteins and other biomolecules can be selectively incorporated and/or released and/or transported is provided. The polymer complex includes an aromatic compound ligand, a central metal ion, and an uncoordinating aromatic compound. In the polymer complex, the uncoordinating aromatic compound is intercalated between aromatic compound ligands in a three-dimensional coordination network. Each of two or more kinds of channel groups contains channels identical with one another and having inherent affinity for guest components. The uncoordinating aromatic compound has a specific substituent A at a specific position on the aromatic ring thereof, and the uncoordinating aromatic compound is arranged regularly such that the substituent A is directed to the inside of a specific channel group B out of the two or more kinds of channel groups.
US08530648B2 Diaza-spiro[5.5]undecanes
The invention relates to compound of the formula (I), in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.
US08530646B2 Oxazolidinone derivative having 7-membered hetero ring
The present invention provides a novel oxazolidinone derivative of the formula (I): wherein Rings A and B are defined as in the specification; X1is a single bond, or a heteroatom-containing group selected from the group consisting of —O—, —S—, —NR2—, —CO—, —CS—, —CONR3—, —NR4CO—, —SONR5—, and NR6SO2—, wherein R2, R3, R4, R5, and R6 are independently hydrogen or lower alkyl, or lower alkylene or lower alkenylene each optionally interrupted by said heteroatom containing group; and R1 is hydrogen, or an organic residue which is able to bind to the 5-position of the oxazolidinone ring in oxazolidinone antimicrobial agents, pharmaceutically acceptable salts and solvates thereof which are useful as an antibacterial agent.
US08530642B2 Particulate-soluble glucan preparation
Particulate β-glucan is solubilized at elevated pressure and temperature to form particulate-soluble β-glucan. The particulate-soluble β-glucan is capable of being dried to a powder form and subsequently re-solubilized.
US08530641B2 Sterile hyaluronic acid solutions
Sterilized aqueous solution comprising 0.04% to 0.8% by weight hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and one or more buffer components selected from the group consisting of boric acid, sodium borate and sodium dihydrogen phosphate. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 4% to 18% by weight of sodium chloride and a pH from 6.4 to 7.2. The solution is also filtered through a filter medium that has an average pore size of 0.25 μm or less to provide a sterilized high salt, hyaluronic acid solution.
US08530639B2 Method for isolating a nucleic acid using particulate matter and a composition therefor
A method for isolating a nucleic acid from a biological sample includes applying particulate matter to promote co-aggregation and co-precipitation of insoluble aggregate by directly adding to the biological sample, adding to the biological sample in admixture with a cell lysis buffer, adding to the biological sample treated with a cell lysis buffer, adding to cell lysates in admixture with a buffer for forming denatured protein aggregate; or adding to cell lysates comprising the formed denatured protein aggregate. The particulate matter is selected from the group consisting of a material formed from an element of Ag, Fe, Ti, Al, Sn, Si, Cu, Mo, Ni, W or Zn, an oxide, a carbide, a nitride, a boride and a silicide thereof, and a mixture thereof, a polymer selected from PMMA (Poly Methyl MethAcrylate), polyethylene or polyurethane; and a mixture thereof. The insoluble aggregate comprises denatured protein aggregate and cell debris.
US08530637B2 Optimized DNA sequence of an antibody to improve quality and yield of bacterially expressed antibody fusion proteins
Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.
US08530636B2 Method for regulating protein function in cells in vivo using synthetic small molecules
Methods and compositions for the rapid and reversible destabilizing of specific proteins in vivo using cell-permeable, synthetic molecules are described.
US08530635B2 Cupredoxin derived transport agents and methods of use thereof
The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer.
US08530632B2 Chitosan-containing protective composition
Body tissue and structures may be protected using a fluid containing a mixture of partially crosslinked polysaccharide and a further crosslinker. The mixture desirably is sprayable, forms a fluid protective layer via in situ crosslinking, desirably does not drip or run from a treatment site, and may avoid the use of more rapidly curing but potentially less bioacceptable crosslinkers at the treatment site.
US08530631B2 Synthetic amphiphiles for membrane protein manipulation
The invention provides amphiphilic compounds and methods for manipulating membrane proteins. Compounds of the invention, for example, the compounds of Formulas I-XIX, can be prepared from readily available starting materials. The amphiphilic compounds can manipulate membrane protein at relatively low concentrations compared to many known detergents. The compounds can be used to aid the isolation of membrane proteins, for example, to aid their solubilization and/or purification. The compounds can also be used to aid the functional and structural determination of membrane proteins, including their stabilization and crystallization.
US08530629B2 Lowered affinity antibodies and uses therefor
The present invention provides novel, rationally designed lowered affinity antibodies for use in various in vivo and in vitro applications. The antibodies of the present invention have variable domains that have been designed to reduce or eliminate the antigen binding activity of the parental antibody without altering the overall 3 dimensional antibody structure. Using the antibodies of the present invention in various assays allows researchers to distinguish effects that result from specific antigen-antibody interactions from other, non-specific antibody effects.
US08530628B2 Diagnosis and treatment of diseased and damaged tissue
The present invention relates to the diagnosis and treatment of leukemia and cardiovascular disease, as well as the detection of diseased and damaged tissue. More particularly, the present invention provides methods for targeting calcitonin receptor expressing cells for the diagnosis and treatment of leukemia or cardiovascular disease, and for stimulating wound healing. The invention also provides antibodies to calcitonin receptor expressing cells and methods of imaging or localizing cells expressing calcitonin receptor. Also provided is an enriched population of CTR+/CD34+ cells.
US08530627B2 FcγRIIB specific antibodies and methods of use thereof
The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention.
US08530624B2 Osteoprotegerin variant proteins
The present invention relates to novel osteoprotegerin variant proteins (GYPs) that demonstrate reduced binding affinity for their ligand TRAIL when compared to wild-type osteoprotegerin. Nucleic acids which encode these GYPs are also provided. Recombinant vectors and host cells expressing these GYPs are also encompassed as are methods of producing recombinant GYPs. The present invention also relates to compositions comprising these GYPs, and to methods of treating bone diseases characterised by increased bone turnover and/or loss. The GYPs of the invention are useful for preventing bone resorption and may be used to treat any condition resulting in abnormal bone turnover or bone loss such as osteoporosis, hypercalcemia, Paget's disease of bone, multiple myeloma, bone cancer and bone loss due to rheumatoid arthritis or osteomyelitis, and the like.
US08530623B2 Proteasome-activating lightening peptides and compositions containing same
The present invention relates to depigmenting, lightening and/or whitening peptidic compounds of general formula (I) R1—X1—X2-Asp-Cys-Arg-X3—X4-(AA)p-R2. In addition, the present invention relates to, on the one hand, a cosmetic or pharmaceutical composition comprising at least one peptide of general formula (I), in a cosmetically or dermatologically acceptable medium and, on the other hand, its utilization to depigment, lighten and/or whiten the skin and prevent or treat hyperpigmentation blemishes as well as cutaneous signs due to photo-aging. Lastly, the invention applies to a cosmetic treatment method utilizing said peptidic compounds.
US08530622B2 Proteasome-activating anti-aging peptides and compositions containing same
The present invention relates to peptidic compounds of general formula (I): R1—X1—X2-Asp-Cys-Arg-X3—X4-(AA)p-R2. In addition, the present invention relates to, on the one hand, a cosmetic or pharmaceutical composition comprising at least one peptide of general formula (I), in a cosmetically or pharmaceutically acceptable medium and, on the other hand, its utilization to prevent or treat the cutaneous signs of aging and photo-aging and to protect the skin from aggressions due to UV radiation. Lastly, the invention applies to a cosmetic treatment process intended to prevent and/or combat the cutaneous signs of aging and photo aging.
US08530618B2 Process for recovering a polymer from a solution
Process for recovering a polymer by injection of steam, and optionally liquid water, into a solution of this polymer comprising a polar aprotic organic solvent (PAOS) that has an azeotrope with water and an apolar organic compound that is miscible with the PAOS and immiscible with water and that acts as a phase separation agent (PSA), the boiling point of which is below that of the water/PAOS azeotrope, the amount of steam injected being sufficient to give rise to the substantial removal of the PSA via stripping and that of the PAOS via azeotropic distillation, and the total amount of water being sufficient to give rise to the precipitation of the polymer, this process being characterized in that the polymer solution also comprises an alcohol, at least during the precipitation of the polymer.
US08530614B1 Porphyrin coordination polymer nanospheres and nanorods
A porphyrin coordination polymer nanostructure comprising a network of pyridyl porphyrin molecules and coordinating metal ions coordinatively bound through the pyridyl groups. In some embodiments, the porphyrins are metalloporphyrins. A variety of nanostructures are formed by the network polymer, including nanospheres, polygonal nanostructures, nanorods, and nanofibers, depending on a variety of factors including coordination metal ion, porphyrin type, metal of the metalloporphyrin, and degree of agitation during nanostructure formation. Reduction of coordinating metal ions may be used to form metal nanoparticles on the coordination polymer nanostructure.
US08530613B2 Preparation of meso-porous polymer based nano-polymerized composite material
Disclosed herein is a method for preparation of a meso-porous polymer nano-composite material which includes: drying a solid material having pores under vacuum; adding a first organic solvent to the vacuum dried solid material in the reactor and dispersing the first organic solvent in pores of the solid material; adding a constant amount of a material having radicals or functional groups relative to weight of the mixture containing the solid material and the first organic solvent in a reactor, and agitating the mixture; introducing a polymerization initiator into the reactor; using a second organic solvent to filter and wash the reaction product after completion of the polymerization; and drying the treated product to eliminate the second organic solvent from the same after removal of the unreacted material having radicals or functional groups as well as the polymerization initiator from the product.
US08530609B2 Process for removing metal species in the presence of hydrogen and a porous material and polyester polymer containing reduced amounts of metal species
A process for removing metal species from a composition comprising contacting: a. an oligomer mixture stream comprising the monomers of a partially aromatic polyester polymer and at least one metal species, or b. a molten polyester polymer stream comprising partially aromatic polyester polymers and at least one metal species, with a non-catalytic porous material in the presence of hydrogen to produce a treated stream containing a reduced amount of at least one metal species. There are provided compositions comprising a partially aromatic polyester polymer having an It.V. of at least 0.50 produced in a direct esterification melt phase process, from greater than 0 to less than 50 ppm antimony, and less than 40 ppm cobalt, or produced in an ester exchange melt phase process, having from greater than zero to less than 5 ppm titanium and less than 10 ppm manganese.
US08530608B2 Water-based adhesive for lamination of polymers to metal substrates
What is disclosed is a water-based adhesive composition that is an aqueous dispersion or emulsion of a polymer component having functional groups that are inactive in a reversible manner in the adhesive composition as prepared; and a water-soluble, or water emulsion, or dispersion of a cross linker component having functional groups wherein the functional groups are inactive in a reversible manner in the adhesive composition as prepared. Preferably the adhesive composition has a pH of from 7 to 11 and a volatile stabilizing base component is used to inactivate the functional groups and to provide the pH. The functional groups in the polymer component and the cross linker component are activated when the volatile base is removed during lamination heat treatment. The adhesive composition can be used to adhere a variety of plastic films to metal substrates without reliance on non-water-based adhesives.
US08530606B2 Process for preparing diaryl carbonates
The invention relates to a process for preparing a diaryl carbonate from a dialkyl carbonate and an aryl alcohol using a series of reactive distillation columns.
US08530601B2 Copolymers of epoxy compounds and amino silanes
The present invention provides for a composition comprising the reaction product of a. an oxirane or oxetane compound comprising at least two oxirane or oxetane groups; and b. an amino silane having the formula: N(H)(R1)R2Si(OR3)3-a-b-c(OR4)a(R5Si(OR6)d(R7)e) b Rc with R1 is chosen from the group consisting of H or a monovalent hydrocarbon radical containing one to 20 carbon atoms; R2 and R5 are independently selected from a group consisting of oxygen or a divalent linear or branched hydrocarbon radical consisting of 1-60 carbons; R4 is a hydrocarbon radical that contains 3 to 200 carbon atoms; R3, R6, R7, and R8 and are each independently selected from the group of monovalent linear or branched hydrocarbon radicals having from 1 to 200 carbon atoms; the subscript b is zero or a positive number and has a value ranging from 0 to 3; the subscripts a, and c are zero or positive and have a value ranging from 0 to 3 subject to the limitation that (a+b+c)≦3; the subscripts d and e are zero or positive and have a value ranging from 0 to 3 subject to the limitation that (d+e)≦3.
US08530598B2 Resist composition for immersion exposure, method of forming resist pattern, and fluorine-containing resin
A resist composition for immersion exposure including: a base component (A) which exhibits changed solubility in an alkali developing solution under the action of acid; an acid-generator component (B) which generates acid upon exposure; and a fluorine-containing resin component (F); dissolved in an organic solvent (S), the fluorine-containing resin component (F) including a structural unit (f1) containing a fluorine atom, a structural unit (f2) containing a hydrophilic group-containing aliphatic hydrocarbon group, and a structural unit (f3) derived from an acrylate ester containing a tertiary alkyl group-containing group or an alkoxyalkyl group.
US08530593B2 Catalyst compounds and use thereof
This invention relates to Group 4 dialkyl compounds supported by a pyridyl-amido-aryl (“PAA”), an anisole-amido-aryl (“AAA”), a phenoxy-amido-pyridyl (“PAPY”), an anisole-amido-phenoxy (“AAP”) or a anisole-amido-phenoxy (“AAP”) tridentate ligand. Such compounds can polymerize olefins, such as ethylene.
US08530589B2 Print processing for patterned conductor, semiconductor and dielectric materials
Embodiments relate to printing features from an ink containing a material precursor. In some embodiments, the material includes an electrically active material, such as a semiconductor, a metal, or a combination thereof. In another embodiment, the material includes a dielectric. The embodiments provide improved printing process conditions that allow for more precise control of the shape, profile and dimensions of a printed line or other feature. The composition(s) and/or method(s) improve control of pinning by increasing the viscosity and mass loading of components in the ink. An exemplary method thus includes printing an ink comprising a material precursor and a solvent in a pattern on the substrate; precipitating the precursor in the pattern to form a pinning line; substantially evaporating the solvent to form a feature of the material precursor defined by the pinning line; and converting the material precursor to the patterned material.
US08530583B2 Thermo- and/or photo-sensitive material and insulator film made thereof
A composition for film formation which can form a film suitable for use as an interlayer dielectric in a semiconductor device, etc. and having an appropriate even thickness and can give a film having excellent characteristics including permittivity and Young's modulus; and a dielectric film obtained from the film-forming composition. The composition contains a compound (X) having a functional group which is partly eliminated by heating, irradiation with light, irradiation with radiation, or a combination thereof to generate volatile matter and yield an unsaturated group in the remaining part of the functional group.
US08530581B2 Powder, compositions thereof, processes for making the same, and articles made therefrom
Provided herein is a powder comprising at least one of: (a) a propylene-based elastomer comprising, based on the total weight of said propylene-based elastomer, (i) at least about 60 wt % of propylene-derived units, (ii) about 5 wt % to about 35 wt % of units derived from at least one of ethylene and a C4-C10 alpha-olefin, and said propylene-based elastomer having a heat of fusion, as determined by DSC, of about 75 J/g or less; and (b) a polyolefin-based elastomer having a Shore A hardness, as determined by ISO 868, of less than 95; wherein the powder has an average particle size of from about 30 μm to about 850 μm. The powder is useful for rotational molding and for making articles having unique combination of elasticity, flexibility, and toughness.
US08530580B2 Polymer compositions having improved homogeneity and odour, a method for making them and pipes made thereof
The present invention deals with polymer compositions suitable for making pipes. The compositions comprise a multimodal copolymer of ethylene and one or more alpha-olefins having from 4 to 10 carbon atoms wherein the multimodal ethylene copolymer has a density of from 924 to 960 kg/m3, a melt index MFR5 of from 0.5 to 6.0 g/10 min, a melt index MFR2 of from 0.1 to 2.0 g/10 min and a shear thinning index SHI2.7/210 of from 2 to 50. The compositions further have a level of volatile compounds of at most 100 ppm by weight and/or a homogeneity rating of at most 3. In addition the multimodal copolymer comprises: (A) from 35 to 60% by weight, based on the combined amount of components (A) and (B), of a low molecular weight ethylene polymer selected from ethylene homopolymer and a copolymer of ethylene and one or more alpha-olefins having from 4 to 10 carbon atoms and having a weight average molecular weight of from 5000 to 100000 g/mol and a density of from 945 to 975 kg/m3; and (B) from 40 to 65% by weight, based on the combined amount of components (A) and (B), of a high molecular weight copolymer of ethylene and one or more alpha-olefins having from 4 to 10 carbon atoms and having a weight average molecular weight of from 100000 to 1000000 g/mol and a density of from 890 to 935 kg/m3.
US08530578B2 Pressure sensitive adhesive comprising blend of synthetic rubber and functionalized synthetic rubber bonded to an acrylic polymer
A pressure sensitive adhesive composition is described comprising unfunctionalized (e.g. polyisobutylene) synthetic rubber and an acrylic polymer having functionalized polyisobutylene polymer bonded to the acrylic polymer. In some embodiments, the functionalized polyisobutylene polymer has a first functional group hydrogen bonded with a second functional group present in the acrylic polymer backbone. In other embodiments, the functionalized polyisobutylene polymer is covalently bonded to the acrylic polymer backbone. Also described are adhesive articles, such as a tape, methods of adhesively bonding, and methods of making a pressure sensitive adhesive.
US08530575B2 Tire
A tire satisfying both of the low rolling resistance of the tire and the improvement of tire strength is provided. A tire including sidewall including a rubber composition for sidewall including a rubber composition including a rubber component including 35 to 65% by mass of NR and/or IR, 15 to 55% by mass of a modified BR and 0 to 50% by mass of other rubber and 20 to 40 parts by mass of filler, in which complex elastic modulus E* is 2.0 to 3.5 MPa and tan δ is less than 0.12; case in which cord is covered with a rubber composition for covering case cord including a rubber component including 50 to 80% by mass of NR and/or IR, 20 to 45% by mass of diene rubber of a modified SBR, a modified BR or ENR and 0 to 30% by mass of other rubber and 20 to 40 parts by mass of filler, in which E* is 2.0 to 3.5 MPa and tan δ is less than 0.12; and clinch including a rubber composition for clinch including a rubber component including 30 to 50% by mass of NR and/or IR, 15 to 70% by mass of a modified BR and 0 to 55% by mass of other rubber and 35 to 80 parts by mass of filler, in which E* is 4.5 to 9.0 MPa and tan δ is less than 0.12.
US08530570B2 Use of 2-isopropyl-2-alkyl-1,3-propanediols for preparing polymers
Polymer obtainable by polycondensation or polyadduct formation from monomeric compounds, wherein accompanying use is made as monomeric compound of 2-isopropyl-2-alkyl-1,3-propanediols of the formula I or alkoxylated derivatives thereof.
US08530567B2 Polymer dispersion which comprises a highly branched polycarbonate having unsaturated fatty acid groups
The present invention relates to a polymer dispersion which comprises a highly branched polycarbonate having unsaturated fatty acid groups. The invention further relates to highly branched polycarbonates having groups deriving from unsaturated fatty acids, to a process for preparing such highly branched polycarbonates, and to the use of these highly branched polycarbonates for improving the curing properties of coating compositions based on an aqueous acrylate dispersion.
US08530566B2 Electrically insulating and thermally conductive composition and electronic device
An embodiment of the invention provides an electrically insulating and thermally conductive composition including 5-80 parts by weight of a resin, 20-95 parts by weight of an electrically insulating and thermally conductive powder, and 0.0001-2 parts by weight of a graphene. Another embodiment of the invention also provides an electronic device including the electrically insulating and thermally conductive composition.
US08530565B2 Fiber reinforced propylene resin composition
[Object] The invention provides a fiber reinforced propylene resin composition having interfacial adhesion between a propylene resin and a reinforcing fiber and capable of preparing molded articles having high mechanical properties.[Means for Achieving the Object] The fiber reinforced propylene resin composition comprises: (A) 1 to 75% by weight of a reinforcing fiber, (B) 0.01 to 10% by weight of a first propylene resin containing 50 to 99% by mol of a constituting unit derived from propylene of an olefin component, (C) 0.01 to 10% by weight of a second propylene resin at least containing a carboxylic acid salt bonded to a polymer chain and (D) 5 to 98.98% by weight of a third propylene resin, wherein the order of the weight average molecular weights Mw of the components (B), (C) and (D) satisfy the following relation; component (D)>component (B)>component (C).
US08530562B2 Rubber compositions comprising coupling agents and coating agents and also inorganic fillers
Elastomeric isoprene rubber compositions contain an effective amount of a coupling system (A) as an inorganic filler/elastomer coupling agent, and (B) at least one natural or synthetic rubber elastomer, (C) an inorganic filler as reinforcing filler, (D) other conventional constituents or additives comprising (a) vulcanization agent(s), the coupling system (A) being a particular mixture of the following combination of constituents (A1) and (A2): (A1) is at least one coupling agent selected from among the following functionalized organosilicon compounds of formula (I):[(G0)3SiO1/2]m[(G0)2SiO2/2]n[G0SiO3/2]o[SiO4/2]p[(G2)a(G1)a′(Z—CO—N═N—CO-A)SiO(3-a-a′)/2]g and (A2) is at least one coating agent for the reinforcing filler including one compound with the single function Y in the structure thereof which is capable of bonding physically and chemically to the inorganic filler and resulting in an increase in dispersion of the charge within the rubber matrix and a reduction in viscosity of the composition.
US08530560B2 Porous biocompatible polymer material and methods
Embodiments described include devices and methods for forming a porous polymer material. Devices disclosed and formed using the methods described include a spacer for spinal fusion, craniomaxillofacial (CMF) structures, and other structures for tissue implants.
US08530559B2 Composite of organic compound and copper nanoparticles, composite of organic compound and copper(I) oxide nanoparticles, and methods for producing the composites
Provided is a composite including copper nanoparticles or copper(I) oxide nanoparticles and a thioether-containing organic compound represented by X(OCH2CHR1)nOCH2CH(OH)CH2SZ [X represents an alkyl group; R1 represents a hydrogen atom or a methyl group; n represents an integer of 2 to 100; R1 is independent between repeating units and may be the same or different; and Z represents an alkyl group, an allyl group, an aryl group, an arylalkyl group, —R2—OH, —R2—NHR3, or —R2—(COR4)m (where R2 represents a saturated hydrocarbon group; R3 represents a hydrogen atom, an acyl group, an alkoxycarbonyl group, or a benzyloxycarbonyl group; R4 represents a hydroxy group, an alkyl group, or an alkoxy group; and m represents 1 to 3)]. Provided is a method for producing a composite of an organic compound and copper nanoparticles or a composite of an organic compound and copper(I) oxide nanoparticles, the method including reducing a copper compound in the presence of a thioether-containing organic compound represented by the general formula (1) above.
US08530558B2 Plasticizers comprising poly(trimethylene ether) glycol esters
Plasticizers comprising monoesters and/or diesters of poly(trimethylene ether) glycol are provided. The plasticizers can be used in plasticizing a variety of base polymers.
US08530548B2 Fibre-reinforced thermoplastic material
The invention concerns a fiber-reinforced thermoplastic material containing airlaid cellulose fiber material, and uses thereof.
US08530545B2 Copolymers of nanoparticles, vinyl monomers and silicone
A copolymer comprises the reaction product of (a) (meth)acrylate functionalized nanoparticles, (b) vinyl monomer, and (c) mercapto-functional silicone. The (meth)acrylate functionalize nanoparticles are selected from the group consisting of silica nanoparticles, zirconia nanoparticles, titania nanoparticles, and combinations thereof.
US08530544B2 Modification of the surface chemistry of macromolecular species in the presence of a conjugated guanidine
The present invention relates to a method for preparing macromolecular species with a modified surface, comprising a step (e) in which macromolecular species (M), initially carrying —OH and/or —SH functions, are brought into contact with: a catalyst (C) carrying at least one conjugated guanidine function; and reactive species (E), comprising reactive groups including: (i) at least one group including an a,b-unsaturated carbonyl group C═C—C═O and/or an a,b-unsaturated thiocarbonyl group C═C—C═S; and/or (ii) at least one heterocyclic group comprising from 3 to 5 ring members, said group being selected from cyclic ethers, cyclic thioethers and aziridine rings; and/or (iii) at least one group selected from isocyanate —N═C═O or thioisocyanate —N═C═S groups, and trivalent groups of formula >C═CZ—, where Z is an electron-withdrawing group. The invention also relates to the macromolecular species with a modified surface that are obtained in this context.
US08530541B2 Cement compositions including polymer particles
Cement compositions comprising polymeric particles with inorganic fillers have utilities in the context of well cementing. The fillers improve bonding between the polymeric particles and the cement matrix leading to improved mechanical parameters of the cement system. The filled particles may also lead to improved mixability and slurries that are easier to optimise.
US08530539B2 Curable resin composition for nanoimprint
Disclosed is a photocurable resin composition for nanoimprint, containing a curable monomer component with or without a binder resin. The composition further contains 0.001 to 5 parts by weight of a compound having a reactive functional group and a hydrophobic functional group in the same molecular skeleton, per 100 parts by weight of the total amount of the curable monomer component and binder resin. Preferably, the reactive functional group is at least one functional group selected from the group consisting of hydroxyl groups, epoxy groups, vinyl ether groups, oxetanyl groups, alkoxysilane groups, and free-radically polymerizable vinyl groups, and the hydrophobic functional group is at least one functional group selected from the group consisting of fluorine-containing groups, alkylsilane groups, alicyclic hydrocarbon groups, and aliphatic hydrocarbon groups having 4 or more carbon atoms.
US08530538B2 Ink composition
An ultraviolet hardenable ink composition excelling in the wetting characteristic (repellence prevention) of ink having impacted a recording medium. There is provided an ultraviolet hardenable ink composition characterized by containing a polyester-modified polydimethylsiloxane as a surfactant in an amount of 0.01 to 1% based on the ultraviolet hardenable ink. Preferably, at least allyl glycol and/or a N-vinyl compound is contained as a polymerizable compound. Incorporation of the polyester-modified polydimethylsiloxane in the surfactant has realized enhancing of the wetting characteristic on all nonabsorptive material surfaces and avoiding of ink repellence.
US08530536B2 Self-lubricating pharmaceutical syringe stoppers
In one aspect, a self-lubricating component is provided for a pharmaceutical packaging assembly. The self-lubricating component comprises a polymer composition and an effective amount of a lubricating additive such as, for example, boron nitride. In another aspect, a pharmaceutical packaging assembly may be provided having a surface thereof coated with a lubricating composition comprising boron nitride. The pharmaceutical packaging composition may be, for example, a pre-filled syringe comprising a body (barrel) and a plunger assembly.
US08530528B2 Water-forming hydrogenation reactions utilizing enhanced catalyst supports and methods of use
Improved reaction efficiencies are achieved by the incorporation of enhanced hydrothermally stable catalyst supports in various water-forming hydrogenation reactions or reactions having water-containing feeds. Examples of water-forming hydrogenation reactions that may incorporate the enhanced hydrothermally stable catalyst supports include alcohol synthesis reactions, dehydration reactions, hydrodeoxygenation reactions, methanation reactions, catalytic combustion reaction, hydrocondensation reactions, and sulfur dioxide hydrogenation reactions. Advantages of the methods disclosed herein include an improved resistance of the catalyst support to water poisoning and a consequent lower rate of catalyst attrition and deactivation due to hydrothermal instability. Accordingly, higher efficiencies and yields may be achieved by extension of the enhanced catalyst supports to one or more of the aforementioned reactions.
US08530525B2 Methods and compositions for protecting and treating neuroinjury
A method and composition for protecting and/or treating neuroinjury are disclosed. In one aspect, the present application discloses a method for protecting and/or treating a subject from organophosphate-induced neuronal injury. The method comprises administering to a subject an effective amount of 4R cembranoid, 4S cembranoid or a cembranoid analogue. In another aspect, the application discloses neuroprotective pharmaceutical compositions for protecting and/or treating a subject from organophosphate-induced neuronal injury. A kit for protecting and treating a subject from organophosphate-induced neurodamage is also disclosed.
US08530522B2 Organic compounds
The present invention relates to crystalline forms and hydrates of 2-Amino-2-[2-(4-C2-20-alkyl-phenyl)ethyl]propane-1,3-diol, and to the use thereof, in particular in the treatment or prevention of various autoimmune conditions.
US08530520B2 Cycloalkyl-dione derivatives and methods of their use
The present invention is directed to carboxylic acid-containing pharmaceutical compounds where the carboxylic acid moieties have been substituted with cycloalkyl-dione derivatives, as well as tautomers and pharmaceutically acceptable salt forms thereof. These bioisosteric replacements improve the compound's ability to effectively cross the blood brain barrier and result in improved pharmacokinetic, toxicological, and/or safety profiles.
US08530512B2 Broad spectrum gram-positive antimicrobials and anthelmintics with efficacy against drug-resistant strains and Mycobacterium species
The present invention provides compounds and methods of using of the compounds as anti-infective and anthelminitc agents. In a preferred embodiment, the present invention provides the following compound of Formula III: wherein: R1 is not H when R2 is H and R2 is not H when R1 is H, further wherein R1 is OH or CH(2n+1)O, wherein n is 1-10; R2 is OH or CH(2n+1)O, where n is 1-10; W is alkyl, phenyl, halophenyl, pyridyl, piperidyl, or a substituted or unsubstituted aryl group, including unsubstituted and substituted aromatic heterocycles; and L is an optional linker or linking group selected from O, S, NH, CF2, or CH2, and x=0 or 1, i.e., if x=0, no linking group is present and when x=0, W is not phenyl.
US08530510B2 Polymerizable photoinitiators and radiation curable compositions
A polymerizable Norrish Type II photoinitiators includes an optionally substituted benzophenone group or an optionally substituted thioxanthone group exhibiting improved compatibility with and solubility in radiation curable compositions. Radiation curable compositions and inkjet inks can contain these polymerizable Norrish Type II photoinitiators, exhibiting low extractable amounts of the photoinitiators and their residues after curing.
US08530508B2 Thrombopoietin receptor agonist (TpoRA) kills acute human myeloid leukemia cells
The present invention provides methods of inhibiting human myeloid leukemia cell growth and proliferation by administering a thrombopoietin receptor agonist (TpoRA), a derivative, or variant thereof, to an individual with AML.
US08530504B2 Pyrazolothiazole compound
A compound represented by the formula (I) or pharmacologically acceptable salt thereof exhibits an excellent CRF receptor antagonism wherein X is a nitrogen atom or CH; R1 is -A11-A12; A11 is a single bond or a C1-6 alkylene group; A12 is a hydrogen atom, a C1-6 alkyl group or a C3-6 cycloalkyl group, etc.; R2 is -A21-A22; A21 is a single bond or a C1-6 alkylene group; A22 is a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a non-aromatic heterocyclic group, or a heteroaryl group, etc.; R3 is a C1-6 alkyl group, a C3-6 cycloalkyl group, a C1-6 alkoxy group, a C3-6 cycloalkoxy C1-6 alkyl group, di-C1-6 alkyl amino group, a halogen atom, a cyano group, a formyl group, or a carboxyl group, etc; R4 is a hydrogen atom or a C1-6 alkoxy group; R5 is a halogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R6 is a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkylthio group, or a C1-6 alkyl sulfinyl group etc.; and R7 is a C1-6 alkyl group, a C1-6 alkoxy group, or a C1-6 alkylthio group.
US08530502B2 Application methods to rapidly alter disease and injury states using molecular transport of B6
The present invention discloses methods of application employing B51B6 vitamins in molecular transport creams or gels to deliver B6 in a high dose to bring about therapeutic ways in human or mammal tissues to reverse a disease process or injury to bring about normal function of the affected tissues. Examples of disease changes to normal include, but are not limited to strokes, cellulitis, facial acne, precancerous lesions, nerve injury like paresthesia, periorbital hematoma, pentathol general anesthesia recovery, headaches, improved sight, hypothyroidism, dental pain, dental gingivitis, insect bites, delayed hypersensitivity states, phlebitis of veins and synergism of steroid activity.
US08530498B1 Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
US08530497B2 Crystalline salts of a potent HCV inhibitor
This invention relates to novel tris(hydroxymethyl)aminomethane, choline and N-methyl-D-glucamine salt forms of the following Compound (1) and methods for the preparation thereof, pharmaceutical compositions thereof, and their use in the treatment of Hepatitis C Viral (HCV) infection:
US08530496B2 Compositions and methods for treating cancer
The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the antitumor compound.
US08530494B2 Buprenophine analogs
The present invention is directed to Buprenorphine Analog compounds of the Formula I, Formula II or Formula III shown below, wherein R1, R2, R8, R3, R3a, R3b, X, Z and Y are as defined herein. Compounds of the Invention are useful for treating pain and other conditions modulated by activity of opioid and ORL1 receptors.
US08530493B2 Indolopyridines as Eg5 kinesin modulators
Compounds of a certain formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity.
US08530489B2 5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors
The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
US08530482B2 Halogenated pyrazolo[1,5-A]pyrimidines, processes, uses, compositions and intermediates
The invention provides novel halogenated pyrazolo[1,5-a]pyrimidines of formula (I) wherein R, R1, X and Y have different meanings, and pharmaceutically acceptable salts thereof. Compounds of formula (I) are useful for treating or preventing anxiety, epilepsy and sleep disorders including insomnia, and for inducing sedation-hypnosis, anesthesia, sleep and muscle relaxation. The invention also provides synthetic procedures for preparing said compounds and certain intermediates, as well as intermediates themselves.
US08530475B2 Bridged aryl piperazines derivatives useful for the treatment of CNS, GI-urinary and reproductive disorders
The present invention is directed to bridged aryl piperazine derivatives, pharmaceutical compositions containing them and their use in the treatment of depression and related disorders. The compounds of the present invention are serotonin transport inhibitors and/or modulators of 5HT1A.
US08530470B2 Chromenone derivatives
The invention concerns chromenone compounds of Formula I; or pharmaceutically-acceptable salts thereof, wherein each of R1, R2, R3, R4, R5, n and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.
US08530469B2 Therapeutic combinations of hydroxybenzamide derivatives as inhibitors of HSP90
The invention provides a combination comprising an Hsp90 inhibitor compound of the formula (VII): or tautomer or salt thereof and one or more therapeutic agents selected from topoisomerase I inhibitors; antimetabolites; tubulin targeting agents; DNA binder and topoisomerase II inhibitors; alkylating agents; monoclonal antibodies; anti-hormones; signal transduction inhibitors; proteasome inhibitors; DNA methyl transferases; cytokines; retinoids and HDAC or HAT modulators.
US08530468B2 Bicyclylaryl-aryl-amine compounds and their use
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain bicyclylaryl-aryl-amines compounds of the following formula (referred to herein as BCAA compounds), which, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc., optionally in combination with another agent, for example, (a) a DNA topoisomerase I or II inhibitor; (b) a DNA damaging agent; (c) an antimetabolite or TS inhibitor; (d) a microtubule targeted agent; and (e) ionising radiation:
US08530466B2 Use of 2,4-pyrimidinediamines for the treatment of atherosclerosis
Novel methods and compositions for the prevention and treatment of all forms of atherosclerosis with 2,4-pyrimidinediamine compounds are described. Also disclosed is the coating of prosthetic devices, such as stents, with the compounds of the invention for the prevention and/or treatment of restenosis.
US08530459B2 Swallowtail motifs for imparting water solubility to porphyrinic compounds
Porphyrinic compounds that contain solubilizing groups are described, along with methods of making and using the same and compositions comprising such compounds. Examples of such compounds include compounds compounds of Formula I: wherein: Z is a porphyrinic macrocycle, Alk1 and Alk2 are each independently an alkylidene chain; L is a linking group or is absent; R1 is preferably an ionic group or polar group; R2 is an ionic group, polar group, bioconjugatable group, or targeting group; R3 is present or absent and when present is a halo group, bioconjugatable group, or targeting group, n is O or 1 (that is, the CH group is present, or Alk1 and Alk2 are bonded directly to a carbon of the porphyrinic macrocycle Z); or a salt thereof.
US08530457B2 Method for the treatment of lymphangioleiomyomatosis (LAM)
Treatment of lymphangioleiomyomatosis with the MEK1/2 inhibitor CI-1040 delayed the development of primary tumors and blocked the estrogen-induced lung metastases in treated animals. Such treatment also reduced the number of circulating ELT3 cells and decreased their lung colonization after intravenous injection.
US08530454B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of psoriasis
The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, psoriasis.
US08530449B2 Composition for a topical ophthalmic clear colloidal liquid which undergoes a liquid-gel phase transition in the eye
The present invention is directed to a topical ophthalmic composition for a liquid comprised of clear colloidal polar nanolipids delivered in submicron sized particles (Nanopids™), aqueous colloidal lubricants, aqueous polymers, emulsifies, and a unique stabilizing buffer system, which undergoes a liquid-gel phase transition in the eye. Said composition is designed to deliver advanced eye lubricants, protect the three (3) layers of corneal film from dryness, and provide a unique system of Dry Eye treatment that addresses and treats all three layers of corneal tear film. Said composition is further designed to provide a superior delivery system of various Active Pharmaceutical Ingredients (APIs), and/or anti-infective/antibiotic/anti-fungal agents, accepted as safe and efficacious for ophthalmic use.
US08530448B2 Compounds and methods for inhibiting selectin-mediated function
Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids, which include a portion or analogue thereof) linked to a carbohydrate or glycomimetic.
US08530440B2 dsRNA delivery composition and methods of use
The present invention provides for compositions comprising a cucurbitacin bait for stimulating insect feeding and a dsRNA—such as for eliciting RNAi mediated gene silencing in an insect. The present invention also provides for methods of delivering a dsRNA molecule to an insect, inhibiting protein expression in an insect, and killing an insect by providing a dsRNA molecule.
US08530437B2 Methods for treating cancer using herpes simplex virus expressing antisense to the squamous cell carcinoma related oncogene
An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding an antisense to the squamous cell carcinoma related oncogene (asSCCRO); and an herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a short interfering ribonucleic acid (siRNA) molecule that is capable of repressing or silencing expression of squamous cell carcinoma related oncogene (SCCRO) nucleic acid or polypeptide are disclosed together with methods for generation and applications of such viruses.
US08530436B2 Methods and compositions for transdermal delivery of nucleotides
The present invention relates to formulations and related methods for transdermal delivery of nucleic acids. Specifically, the invention relates to a formulation containing lipids and an alcohol and which is capable of providing effective transdermal delivery of nucleic acid. The formulation can be used effectively to deliver nucleic acids for gene therapy and the treatment of disease.
US08530427B2 Methods for modulating resistance to apoptosis using KLK6
This document provides methods and materials involved in modulating a cell's ability to be resistant to apoptosis. For example, methods and materials for exposing cells to KLK6 polypeptides, or increased KLK6 polypeptide activity, to promote resistance to apoptosis are provided. In addition, methods and materials for reducing the ability of KLK6 polypeptides to promote resistance to apoptosis are provided.
US08530423B2 Anxiolytic compositions containing αs1-casein-derived peptides
The invention relates to pharmaceutical compositions and food products containing peptides derived from the αs1-casein in milk and having benzodiazepine-type activity and particularly, anxiolytic activity.
US08530418B2 Cytokine containing compositions
The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof.
US08530416B2 Variants of pigment epithelium derived factor and uses thereof
The present invention provides anti-angiogenic variants of pigment epithelium derived factor (PEDF) comprising at least one altered phosphorylation site, polynucleotides encoding same and uses thereof. Particularly, the present invention provides variants of human PEDF comprising at least one amino acid substitution at serine residues (24), (114), and (227). The PEDF variants are potent anti-angiogenic factors, and thus useful in treating diseases or disorders associated with neovascularization.
US08530413B2 Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicamentsThe invention relates to heterocyclically substituted methoxyphenyl derivatives with an oxo group, and to physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R10, X, n, B1, B2, B3 and B4 are each defined as specified, and to the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
US08530409B1 Stable pexiganan formulation
The invention provides chemically and physically stable topical formulations of pexiganan, and methods of preparing the same.
US08530399B2 Conditioning shampoo compositions
An aqueous conditioning shampoo composition comprising an anionic cleansing surfactant and a gel network comprising: (i) a fatty material selected from C12-C22 fatty alcohol, C12-C22 fatty acid, C12-C22 fatty amide or mixtures thereof and (ii) hydrophobic particulates having a melting point of greater than that of the fatty material.
US08530397B2 Additive compositions
Compositions in the form of lubricating oil compositions, greases, fuels or functional fluids containing, in the form of Michael adducts, N-substituted phenylenediamine additives in which at least one of the substituents on the N atoms carries a carbonyl group that is connected to an alkyl, alkoxyalkyl, or alkylthioalkyl group either directly or via an oxygen atom.
US08530396B2 Grease composition for constant velocity joint and constant velocity joint
The invention provides a grease composition for constant velocity joint containing the components (a) to (g) below and a constant velocity joint containing said composition. (a) a diurea thickening agent having the following formula (1): R1NH—CO—NH—C6H4-p-CH2—C6H4-p-NH—CO—NHR2  (1) wherein R1 and R2 may be the same or different and represent C8-C20 alkyl groups, (b) an ester synthetic oil, (c) a mineral oil and/or a synthetic hydrocarbon oil, (d) a molybdenum dialkyldithiocarbamate, (e) molybdenum disulfide, (f) a polytetrafluoroethylene, and (g) a zinc dithiophosphate compound. The grease composition of the invention reduces variations in rotational resistance of the constant velocity joint at a low temperature.
US08530394B2 Sterically hindered N-methyl secondary and tertiary amine sulfur scavengers and methods for making and using same
An new class of oil-soluble, sulfur scavengers or converts are disclosed where the scavengers include substantially monomeric aldehyde-amine adducts from the reaction of at least one sterically hindered primary or secondary amine and a molar excess of at least one aldehyde. Methods are also disclosed for reducing, reducing below a given level or eliminating noxious sulfur species from fluids using the inventive scavengers and for making the inventive scavengers.
US08530392B2 Test agent for visceral obesity and use thereof
Disclosed are: a method for detecting (diagnosing) visceral obesity in a subject; a test agent useful for the method; a method for searching for a substance that can be used as an active ingredient for ameliorating visceral obesity; and an ameliorating agent for visceral obesity or a medicinal agent for preventing a metabolic disease developed as a result of the progression of visceral obesity. As the test agent, a polynucleotide which comprises at least 15 nucleotides and can hybridize with a nucleotide sequence for coiled-coil domain containing protein 3 (CCDC3) gene or a nucleotide sequence complementary to the nucleotide sequence under stringent conditions or an antibody capable of recognizing CCDC3 protein is used.
US08530391B2 Method and device for cold gas spraying
A device for coating at least one substrate or for producing at least one molding by means of at least one cold gas spraying pistol, wherein the cold gas spraying pistol and the substrate or molding to be coated are arranged in a vacuum chamber, and also a method for cold gas spraying relating thereto in such a manner that while eliminating the wire production, the coil winding and also the cast in procedure, a thoroughly compact coil without a degree of freedom of movement (elimination of the quench risk) can be produced, it is suggested that the particles have at least to some extent an electrically conducting, in particular superconducting, property and at least to some extent an electrically poorly conducting or electrically insulating property.
US08530388B2 Cyclopentadione derived herbicides
Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
US08530386B2 Herbicidal compositions for tolerant or resistant sugar beet crops
Suitable for controlling harmful plants in sugar beet crops composed of tolerant or resistant mutants or transgenic sugar beet plants are herbicide combinations (A)+(B), if appropriate in the presence of safeners, with an effective content of (A) broad-spectrum herbicides from the group (A1) glufosinate (salts) and related compounds, (A2) glyphosate (salts) and related compounds such as sulfosate and (A3) imidazolinones or their salts and (B) herbicides from the group consisting of (B0) one or more structurally different herbicides from the abovementioned group (A) or (B1) foliar- and predominantly soil-acting herbicides which are active against monocotyledonous and dicotyledonous harmful plants, or (B2) herbicides which are active predominantly against dicotyledonous harmful plants, and (B3) herbicides which are predominantly foliar-acting and which can be employed against monocotyledonous harmful plants, or (B4) herbicides which are both foliar- and soil-acting and which can be employed against monocotyledonous harmful plants, or of herbicides of more than one of groups (B0) to (B4), the sugar beet crops tolerating the herbicides (A) and (B) present in the combination, if appropriate in the presence of safeners. If appropriate, the combinations are also suitable for regulating the growth or else for controlling the yield or the constituents of sugar beet plants.
US08530383B2 Safening 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylate herbicide injury on cereal crops
Herbicidal injury caused by 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylates in wheat and barley is reduced with the use of AD67 (MON 4660), benoxacor, 2-CBSU, daimuron, dichlormid, dicyclonon (BAS 145 138H), fenchlorazole-ethyl, fenclorim, fluxofenim, furilazole (MON 13900), glyphosate, isoxadifen-ethyl, mefenpyr-diethyl, naphthalic anhydride, oxabetrinil and mixtures thereof.
US08530382B2 Anthranilic diamide compositions for propagule coating
Disclosed is an insecticidal composition comprising by weight based on the total weight of the composition: (a) from about 9 to about 91% of one or more anthranilic diamide insecticides; and (b) from about 9 to about 91% of a nonionic ethylene oxide-propylene oxide block copolymer component having a water solubility of at least about 5% by weight at 20° C., a hydrophilic-lipophilic balance value of at least about 5 and an average molecular weight ranging from about 1500 to about 20000 daltons; wherein the ratio of component (b) to component (a) is about 1:10 to about 10:1 by weight. Also disclosed is a geotropic propagule coated with an insecticidally effective amount of the aforedescribed composition. Further disclosed is a liquid composition consisting of about 5 to 80 weight % of the aforedescribed composition and about 20 to 95 weight % of a volatile aqueous liquid carrier, and a method for protecting a geotropic propagule and plant derived therefrom from a phytophagous insect pest, the method comprising coating the propagule with an insecticidally effective amount of the aforedescribed liquid composition and then evaporating the volatile aqueous liquid carrier.
US08530379B2 Thermosensitive recording material and production method thereof
To provide a thermosensitive recording material, containing a base, a thermosensitive recording layer disposed on the base and containing a leuco dye and a color developer, an intermediate layer disposed on the thermosensitive recording layer, and a protective layer disposed on the intermediate layer, wherein the intermediate layer contains a resin, and an aziridine compound.
US08530376B2 Reversible thermosensitive recording medium
To provide a reversible thermosensitive recording medium, which contains: a base; and a reversible thermosensitive recording layer disposed on the base, wherein the base contains a first support, an electronic information recording module, an adhesive covering the first support, and a second support in a surface of which a groove is formed as a laser mark by laser marking, and wherein a ratio of a maximum depth A to a total thickness of the reversible thermosensitive recording medium is 20% or less, where the maximum depth A is a length from the surface of the second support to a bottom of the groove of the laser mark with respect to a thickness direction of the reversible thermosensitive recording medium.
US08530360B2 Method for low stress flip-chip assembly of fine-pitch semiconductor devices
A device including a first body (101) with terminals (102) on a surface (101a), each terminal having a metallic connector (110), which is shaped as a column substantially perpendicular to the surface. Preferably, the connectors have an aspect ratio of height to diameter of 2 to 1 or greater, and a fine pitch center-to-center. The connector end (110a) remote from the terminal is covered by a film (130) of a sintered paste including a metallic matrix embedded in a first polymeric compound. Further a second body (103) having metallic pads (140) facing the respective terminals (102). Each connector film (130) is in contact with the respective pad (140), whereby the first body (101) is spaced from the second body (103) with the connector columns (110) as standoff. A second polymeric compound (150) is filling the space of the standoff.
US08530359B2 Modulated metal removal using localized wet etching
An apparatus for wet etching metal from a semiconductor wafer comprises a wafer holder for rotating a wafer and a plurality of nozzles for applying separate flow patterns of etching liquid to the surface of the wafer. The flow patterns impact the wafer in distinct band-like impact zones. The flow pattern of etching liquid from at least one nozzle is modulated during a total etching time control the cumulative etching rate in one local etch region relative to the cumulative etching rate in one or more other local etch regions. Some embodiments include a lower etch chamber and an upper rinse chamber separated by a horizontal splash shield. Some embodiments include a retractable vertical splash shield used to prevent splashing of etching liquid onto the inside walls of a treatment container. An etch-liquid delivery system includes a plurality of nozzle flow paths having corresponding nozzle flow resistances, and a plurality of drain flow paths having corresponding drain flow resistances. Nozzle flow resistances and drain flow resistances are matched so that switching the flow from a nozzle to a corresponding drain flow path does not change the flow rate of etching liquid through other nozzles. A non-wafer-contacting measuring device measures a metal thickness on a rotating semiconductor wafer during metal wet etching by immersing a plurality of electrodes in etching liquid in close proximity to the wafer surface of the rotating wafer and determining electrical resistance between a plurality of electrodes.
US08530346B2 Process of forming an electronic device including a conductive stud over a bonding pad region
An electronic device can include an interconnect level including a bonding pad region. An insulating layer can overlie the interconnect level and include an opening over the bonding pad region. In one embodiment, a conductive stud can lie within the opening and can be substantially encapsulated. In another embodiment, the electronic device can include a barrier layer lying along a side and a bottom of the opening and a conductive stud lying within the opening. The conductive stud can substantially fill the opening. A majority of the conductive stud can lie within the opening. In still another embodiment, a process for forming an electronic device can include forming a conductive stud within the opening wherein from a top view, the conductive stud lies substantially completely within the opening. The process can also include forming a second barrier layer overlying the conductive stud.
US08530344B1 Method for manufacturing fine-pitch bumps and structure thereof
A method for manufacturing fine-pitch bumps comprises providing a silicon substrate; forming a titanium-containing metal layer having a plurality of first zones and a plurality of second zones on the silicon substrate; forming a photoresist layer on the titanium-containing metal layer; patterning the photoresist layer; forming a plurality of copper bumps having a plurality of first top surfaces and a plurality of first ring surfaces; heating the photoresist layer to form a plurality of body portions and removable portions; etching the photoresist layer; forming a plurality of bump protection layers on the titanium-containing metal layer, the first top surface and the first ring surface, each of the bump protection layers comprises a bump coverage portion; plating a plurality of gold layers at the bump coverage portion; eventually, removing the second zones to enable each of the first zones to form an under bump metallurgy layer.
US08530341B2 Method of manufacturing organic light emitting diode display
A method of manufacturing an organic light emitting diode display, the method including forming an amorphous silicon layer on a buffer layer disposed on substrate, heat-treating the amorphous silicon film to form a microcrystalline silicon film; and scanning and irradiating a linear laser beam twice or more onto the microcrystalline silicon film to form a polysilicon film, wherein a subsequent scanning of the linear laser beam partially overlaps previous scanning of the linear laser beam in a width direction.
US08530337B1 Method of large-area circuit layout recognition
Methods for detecting the physical layout of an integrated circuit are provided. The methods of the present disclosure allow large area imaging of the circuit layout without requiring tedious sample preparation techniques. The imaging can be performed utilizing low-energy beam techniques such as scanning electron microscopy; however, more sophisticated imaging techniques can also be employed. In the methods of the present disclosure, spalling is used to remove a portion of a semiconductor layer including at least one semiconductor device formed thereon or therein from a base substrate. In some cases, a buried insulator layer that is located beneath a semiconductor layer including the at least one semiconductor device can be completely or partially removed. In some cases, the semiconductor layer including the at least one semiconductor device can be thinned. The methods improve the detection quality that the buried insulator layer and a thick semiconductor layer can reduce.
US08530335B2 Method for manufacturing semiconductor device
A release layer formed over a substrate; at least one of thin film integrated circuits is formed over the release layer; a film is formed over each of the at least one of thin film integrated circuits; and the release layer is removed by using an etchant; thus, the at least one of thin film integrated circuits is peeled from the substrate. A semiconductor device is formed by sealing the peeled thin film integrated circuit by lamination or the like.
US08530333B2 Semiconductor device and manufacturing method thereof
An object is to provide a semiconductor device which solves a problem that can occur when a substrate having an insulating surface is used. The semiconductor device includes a base substrate having an insulating surface; a conductive layer over the insulating surface; an insulating layer over the conductive layer; a semiconductor layer having a channel formation region, a first impurity region, a second impurity region, and a third impurity region provided between the channel formation region and the second impurity region over the insulating layer; a gate insulating layer configured to cover the semiconductor layer; a gate electrode over the gate insulating layer; a first electrode electrically connected to the first impurity region; and a second electrode electrically connected to the second impurity region. The conductive layer is held at a given potential.
US08530332B2 Method for manufacturing SOI substrate and semiconductor device
An object is to provide an SOI substrate with excellent characteristics even in the case where a single crystal semiconductor substrate having crystal defects is used. Another object is to provide a semiconductor device using such an SOI substrate. A single crystal semiconductor layer is formed by an epitaxial growth method over a surface of a single crystal semiconductor substrate. The single crystal semiconductor layer is subjected to first thermal oxidation treatment to form a first oxide film. A surface of the first oxide film is irradiated with ions, whereby the ions are introduced to the single crystal semiconductor layer. The single crystal semiconductor layer and a base substrate are bonded with the first oxide film interposed therebetween. The single crystal semiconductor layer is divided at a region where the ions are introduced by performing thermal treatment, so that the single crystal semiconductor layer is partly left over the base substrate. The single crystal semiconductor layer left over the base substrate is irradiated with laser light. The single crystal semiconductor layer left over the base substrate is subjected to second thermal oxidation treatment to form a second oxide film. Then, the second oxide film is removed.
US08530329B2 Methods of fabricating semiconductor devices having various isolation regions
A method of fabricating a semiconductor device includes forming a first trench and a second trench in a semiconductor substrate, forming a first insulator to completely fill the first trench, the first insulator covering a bottom surface and lower sidewalls of the second trench and exposing upper sidewalls of the second trench, and forming a second insulator on the first insulator in the second trench.
US08530326B2 Method of fabricating a dummy gate structure in a gate last process
A method of semiconductor device fabrication including forming a plurality of gate structures in a first portion of a substrate, wherein the plurality of gate structures have a first height. A first metal gate structure is formed in a second portion of the substrate, the first metal gate structure being surrounded by an isolation region. A plurality of dummy gate structures is formed in the second portion of the substrate. The plurality of dummy gate structures are configured in a ring formation encircling the metal gate structure and the isolation region. The plurality of dummy structures have a top surface that is substantially planar with the plurality of gate structures and covers at least 5% of a pattern density of the second portion of the substrate.
US08530324B2 Methods of fabricating microelectronic memory devices having flat stopper layers
Memory devices comprise a microelectronic substrate including a cell array region and a peripheral region adjacent the cell array region, the cell array region including therein an array of memory cells and the peripheral region including therein peripheral circuits for the array of memory cells, the microelectronic substrate including a lower layer that extends across the cell array region and across the peripheral region and that includes a flat outer surface from the cell array region to the peripheral region. A signal transfer conductor layer extends in the cell array region beneath the flat outer surface of the lower layer and extends in the peripheral region above the flat outer surface of the lower layer. An insulating layer is provided on the lower layer, the insulating layer extending across the cell array region and the peripheral region and also including a flat outer surface from the cell array region to the peripheral region. A flat stopper layer is provided on the flat outer surface of the insulating layer and extending across the cell array region and the peripheral region. Finally, an array of memory cell capacitor storage nodes is provided in the cell array region that extend beyond the flat stopper layer and that penetrate through the flat stopper layer and the insulating layer. Related methods are also provided.
US08530320B2 High-nitrogen content metal resistor and method of forming same
A thin film metal resistor is provided that includes an in-situ formed metal nitride layer that is formed in a lower region of a deposited metal nitride layer. The in-situ formed metal nitride layer, together with the overlying deposited metal nitride layer, from a thin film metal resistor which has a nitrogen content that is greater than 60 atomic % nitrogen. The in-situ formed metal nitride layer is present on a nitrogen enriched dielectric surface layer. In accordance with the present disclosure, the in-situ formed metal nitride layer is formed during and/or after formation of the deposited metal nitride layer by reacting metal atoms from the deposited metal nitride layer with nitrogen atoms present in the nitrogen enriched dielectric surface layer. The presence of the in-situ formed metal nitride layer in the lower region of the metal nitride layer provides a two-component metal resistor having greater than 60 atomic % nitrogen therein.
US08530319B2 Vertical silicide e-fuse
An apparatus and a method of manufacturing an e-fuse includes a substrate, a patterned gate insulator on the substrate, and a patterned gate conductor on the patterned gate insulator. The patterned gate conductor has sidewalls and a top. A silicide contacts the sidewalls of the patterned gate conductor, the top of the patterned gate conductor, and a region of the substrate adjacent the patterned gate insulator and the patterned gate conductor.
US08530318B2 Memory cell that employs a selectively fabricated carbon nano-tube reversible resistance-switching element formed over a bottom conductor and methods of forming the same
In some aspects, a method of fabricating a memory cell is provided that includes: (1) fabricating a first conductor above a substrate; (2) selectively fabricating a carbon nano-tube (“CNT”) material above the first conductor by: (a) fabricating a CNT seeding layer on the first conductor, wherein the CNT seeding layer comprises silicon-germanium (“Si/Ge”), (b) planarizing a surface of the deposited CNT seeding layer, and (c) selectively fabricating CNT material on the CNT seeding layer; (3) fabricating a diode above the CNT material; and (4) fabricating a second conductor above the diode. Numerous other aspects are provided.
US08530317B1 Corner rounding to improve metal fill in replacement gate process
A replacement gate process for fabricating a semiconductor device with metal gates includes forming a dummy gate stack, patterning dummy gates, doping source and drain regions for the gates, and forming an inter-level dielectric layer that overlays the source and drain regions. The sacrificial layer of the dummy gates is removed to form trenches using a three stage process. The first stage begins the trenches, whereby trenches entrance corners are exposed. The second stage is an etch that rounds the corners. The third stage is a main etch for the sacrificial layer, which is typically polysilicon. The corner rounding of the second stage improves the performance of the third stage and results in a better metal back fill including a reduction in pit defects. The process improves overall device yield in comparison to an otherwise equivalent process that omits the corner rounding step.
US08530316B2 Method for fabricating a semiconductor device
A method for fabricating a semiconductor device, the method including growing a first semiconductor structure comprising a first semiconductor material on a surface of a substrate, wherein growing the first semiconductor structure includes forming a semiconductor particle comprising the first semiconductor material on a second semiconductor structure of the semiconductor device. The method further includes forming a protection layer of a second semiconductor material on the first semiconductor structure, wherein forming the protection layer includes forming the protection layer on the semiconductor particle. The method further includes removing a portion of the protection layer, wherein removing the portion of the protection layer includes fully removing the protection layer on the semiconductor particle and the semiconductor particle.
US08530314B2 Solid-state memory manufacturing method
A method of at least one embodiment of the present invention of manufacturing a solid-state memory is a method of manufacturing a solid-state memory, the solid-state memory including a recording film whose electric characteristics are varied by phase transformation, the method including: forming the recording film by forming a laminate of two or more layers so that a superlattice structure is provided, each of the layers having a parent phase which shows solid-to-solid phase-transformation, the recording film being formed at a temperature not lower than a temperature highest among crystallization temperatures of the parent phases. It is thus possible to manufacture a solid-state memory which requires lower current for recording and erasing data and has a greater rewriting cycle number.
US08530312B2 Vertical devices and methods of forming
Vertical devices and methods of forming the same are provided. One example method of forming a vertical device can include forming a trench in a semiconductor structure, and partially filling the trench with an insulator material. A dielectric material is formed over the insulator material. The dielectric material is modified into a modified dielectric material having an etch rate greater than an etch rate of the insulator material. The modified dielectric material is removed from the trench via a wet etch.
US08530311B2 Method of manufacturing semiconductor device
Disclosed herein is a method of manufacturing a semiconductor device. The method comprises forming a first silicon film on a semiconductor substrate, forming a second silicon film on the first silicon film, forming a third silicon film on the second silicon film, and forming a first diffusion barrier film on the third silicon film. The method further comprises performing a thermal treatment to diffuse an impurity included in the second silicon film into at least the first silicon film and the semiconductor substrate, respectively.
US08530309B2 Memory device and method for fabricating the same
A method for forming a memory device includes: forming a tunnel insulation layer, a conductive layer for a floating gate electrode, a charge blocking layer and a conductive layer for a control gate electrode over a substrate; and selectively etching the conductive layer for the control gate electrode, the charge blocking layer and the conductive layer for the floating gate electrode, thereby forming a plurality of gate lines, a plurality of select lines and at least two dummy lines disposed in a gap region between adjacent select lines, wherein the gate lines, the select lines and the dummy lines together construct strings.
US08530307B2 Semiconductor device and fabrication method therefor
There is provided a semiconductor device including bit lines (14) formed in a semiconductor substrate (10), insulating film lines (18) located on the bit lines (14) to successively run in a length direction of the bit lines (14), gate electrodes (16) located above the semiconductor substrate (10) between the bit lines (14), and word lines (20) located on the gate electrodes (18) to run in a width direction of the bit lines (14), a trench region (22) formed between the bit lines (14) and the between word lines (20) in the semiconductor substrate, and there is also provided a fabrication method therefor. According to the present invention, it is possible to provide a semiconductor device where elements can be isolated between the word lines (14) and memory cells can be miniaturized, and to provide a fabrication method therefor.
US08530302B2 Method for manufacturing CMOS FET
A method for manufacturing a CMOS FET comprises forming a first interfacial SiO2 layer on a semiconductor substrate after formation a conventional dielectric isolation; forming a stack a first high-K gate dielectric/a first metal gate; depositing a first hard mask; patterning the first hard mask by lithography and etching; etching the portions of the first metal gate and the first high-K gate dielectric that are not covered by the first hard mask. A second interfacial SiO2 layer and a stack of a second high-K gate dielectric/a second metal gate are then formed; a second hard mask is deposited and patterned by lithograph and etching; the portions of the second metal gate and the second high-K gate dielectric that are not covered by the second hard mask are etched to expose the first hard mask on the first metal gate. The first hard mask and the second hard mask are removed by etching; a polysilicon layer and a third hard mask are deposited and patterned by lithography and etching to form a gate stack; a dielectric layer is deposited and etched to form first spacers. Source/drain regions and their extensions are then formed by a conventional process, and silicides are formed by silicidation to provide contact and metallization.
US08530301B2 MOS device with substrate potential elevation for ESD protection
An integrated circuit (25) formed at a semiconducting surface of a substrate including a common p-layer (38) includes functional circuitry (24) formed on the p-layer (38) including a plurality of terminals (IN, OUT, I/O) coupled to the functional circuitry (24). At least one ESD protection cell (30; in more detail 200) is connected to at least one of the plurality of terminals of the functional circuitry (24). The protection cell includes at least a first Nwell (37) formed in the p-layer (38), a p-doped diffusion (36) within the first Nwell (37) to form at least one Nwell diode comprising an anode (37) and a cathode (36). An NMOS transistor 200 is formed in or on the p-layer (38) comprising a n+ source (43), n+ drain (44) and a channel region comprising a p-region (41) between the source and drain, and a gate electrode (45) on a gate dielectric (46) on the channel region. The terminal of the functional circuit (24, PAD) is coupled to the cathode (36) of the Nwell diode, and the anode (37) of the Nwell diode is connected in series with a path from the drain (44) to the source (43) of the NMOS transistor (200).
US08530299B2 Electronic device including a well region
An electronic device including an integrated circuit can include a buried conductive region and a semiconductor layer overlying the buried conductive region, and a vertical conductive structure extending through the semiconductor layer and electrically connected to the buried conductive region. The integrated circuit can further include a doped structure having an opposite conductivity type as compared to the buried conductive region, lying closer to an opposing surface than to a primary surface of the semiconductor layer, and being electrically connected to the buried conductive region. The integrated circuit can also include a well region that includes a portion of the semiconductor layer, wherein the portion overlies the doped structure and has a lower dopant concentration as compared to the doped structure. In other embodiment, the doped structure can be spaced apart from the buried conductive region.
US08530297B2 Process for fabricating non-volatile storage
Fabricating non-volatile storage includes creating gate stacks with hard masks on top of the gate stacks. The gate stacks include two polysilicon layers and a dielectric layer between the two polysilicon layers. A portion of the hard mask over each gate stack is removed, leaving two separate tapered sections of each of the hard masks positioned above an upper polysilicon layer of the gate stacks. After the removing the portion of the hard masks, fluorine is implanted into the upper polysilicon layer of the gate stacks. Metal is added on the top surface of the upper polysilicon layer of the floating gate stacks. A silicidation process for the metal and the upper polysilicon layer of the gate stacks is preformed and the remaining tapered sections of the hard mask are removed. Other control lines can then be added.
US08530296B2 High voltage transistor using diluted drain
An integrated circuit containing an extended drain MOS transistor may be formed by forming a drift region implant mask with mask fingers abutting a channel region and extending to the source/channel active area, but not extending to a drain contact active area. Dopants implanted through the exposed fingers form lateral doping striations in the substrate under the mask fingers. An average doping density of the drift region under the gate is at least 25 percent less than an average doping density of the drift region at the drain contact active area. In one embodiment, the dopants diffuse laterally to form a continuous drift region. In another embodiment, substrate material between lateral doping striations remains an opposite conductivity type from the lateral doping striations.
US08530292B2 Method for manufacturing a strained channel MOS transistor
A method for manufacturing a strained channel MOS transistor including the steps of: forming, at the surface of a semiconductor substrate, a MOS transistor comprising source and drain regions and an insulated sacrificial gate which partly extends over insulation areas surrounding the transistor; forming a layer of a dielectric material having its upper surface level with the upper surface of the sacrificial gate; removing the sacrificial gate; etching at least an upper portion of the exposed insulation areas to form trenches therein; filling the trenches with a material capable of applying a strain to the substrate; and forming, in the space left free by the sacrificial gate, an insulated MOS transistor gate.
US08530290B2 Thin film transistor, method of fabricating the same, and organic light emitting diode display device including the same
A thin film transistor includes: a substrate; a semiconductor layer disposed on the substrate, and including a channel region, source and drain regions, and edge regions having a first impurity formed at edges of the source and drain regions, and optionally, in the channel region; a gate insulating layer insulating the semiconductor layer; a gate electrode insulated from the semiconductor layer by the gate insulating layer; and source and drain electrodes electrically connected to the semiconductor layer.
US08530286B2 Low power semiconductor transistor structure and method of fabrication thereof
A structure and method of fabrication thereof relate to a Deeply Depleted Channel (DDC) design, allowing CMOS based devices to have a reduced σVT compared to conventional bulk CMOS and can allow the threshold voltage VT of FETs having dopants in the channel region to be set much more precisely. The DDC design also can have a strong body effect compared to conventional bulk CMOS transistors, which can allow for significant dynamic control of power consumption in DDC transistors. The semiconductor structure includes an analog device and a digital device each having an epitaxial channel layer where a single gate oxidation layer is on the epitaxial channel layer of NMOS and PMOS transistor elements of the digital device and one of a double and triple gate oxidation layer is on the epitaxial channel layer of NMOS and PMOS transistor elements of the analog device.
US08530277B2 Integrated circuit packaging system with package on package support and method of manufacture thereof
A method of manufacture of an integrated packaging system includes: providing a substrate; mounting a die over the substrate; mounting an interposer having a slot over the die; covering a first encapsulant over the die and the interposer, a central region of the interposer exposed from the first encapsulant; and forming a hole through the first encapsulant to expose a peripheral portion of the interposer.
US08530276B2 Method for manufacturing a microelectronic device and a microelectronic device thus manufactured
The invention pertains to a method for manufacturing a microelectronic device on a substrate comprising at least one first electrical component and one second electrical component distributed respectively in first and second levels stacked one on top of the other on the substrate, this method comprising: the manufacture of at least one first arm and one second arm of different lengths, each of these arms directly and mechanically linking an electrical pad to a fixed anchoring point on the substrate, and the electrical pad is made inside the first level and then shifted, prior to the electrical connection of the second component, to a position of connection wherein the upper face of the electrical pad is in contact with the interior of the second level parallel to the substrate.
US08530275B2 Semiconductor device, method of manufacturing the semiconductor device, flip chip package having the semiconductor device and method of manufacturing the flip chip package
A semiconductor device can include a semiconductor chip, a protective layer pattern, an under bump metallurgy (UBM) layer, and conductive bumps. The semiconductor chip can include a pad and a guard ring. The protective layer pattern can be formed on the semiconductor chip to expose the pad and the guard ring. The UBM layer can be formed on the protective layer and can directly make contact with the pad and the guard ring. The conductive bumps can be formed on a portion of the UBM layer on the pad. Thus, the UBM layer and the guard ring can directly make contact with each other, so that a uniform current can be provided to the UBM layer on the pad regardless of a thick difference of different portions of the UBM layer.
US08530274B2 Semiconductor device and method of forming air gap adjacent to stress sensitive region of the die
A semiconductor device is made by mounting an insulating layer over a temporary substrate. A via is formed through the insulating layer. The via is filled with conductive material. A semiconductor die has a stress sensitive region. A dam is formed around the stress sensitive region. The semiconductor die is mounted to the conductive via. The dam creates a gap adjacent to the stress sensitive region. An encapsulant is deposited over the semiconductor die. The dam blocks the encapsulant from entering the gap. The temporary substrate is removed. A first interconnect structure is formed over the semiconductor die. The gap isolates the stress sensitive region from the first interconnect structure. A shielding layer or heat sink can be formed over the semiconductor die. A second interconnect structure can be formed over the semiconductor die opposite the first interconnect structure.
US08530267B2 Silicon-based thin film solar cell and method for manufacturing same
A method for manufacturing a silicon-based thin film solar cell including a crystalline silicon photoelectric conversion unit which contains a p-type layer (4p), a crystalline i-type silicon photoelectric conversion layer (4ic), and an n-type layer (4nc) stacked in this order from a transparent substrate side is provided. In one example, an n-type silicon-based thin film layer (4na) is formed on the crystalline i-type silicon photoelectric conversion layer (4ic), the n-type silicon-based thin film layer (4na) having an n-type silicon alloy layer having a film thickness of 1-12 nm and being in contact with the crystalline i-type silicon photoelectric conversion layer.
US08530266B1 Image sensor having metal grid with a triangular cross-section
A backside illuminated image sensor includes a substrate layer having a frontside and a backside. An array of photosensitive pixels is disposed within the substrate layer and is sensitive to light incident through the backside of the substrate layer. A metal grid is disposed over the backside of the substrate layer. The metal grid surrounds each of the photosensitive pixels and defines optical apertures for receiving the light into the photosensitive pixels through the backside. The metal grid includes intersecting wires each having a triangular cross-section. A material layer surrounds the metal grid.
US08530265B2 Method of fabricating flexible artificial retina devices
Fabrication methods for a flexible device for retina prosthesis are described. Layered structures including an array of pixel units may be formed over a substrate. Each pixel unit may comprise a processing circuitry, a micro electrode and a photo sensor. A first set of biocompatible layers may be formed over the layered structures. The substrate may be thinned down to a controlled thickness of the substrate to allow bending of the substrate to the curvature of a retina. A second set of biocompatible layers may be formed over the thinned substrate. The second set of biocompatible layers may be in contact with the first set of biocompatible layers to form a biocompatible seal wrapping around the device to allow long-term contact of the device with retina tissues. Micro electrodes of the pixel units may be exposed through the openings of these biocompatible layers.
US08530264B2 Methods for manufacturing arrays for CMOS imagers
Methods of fabricating complementary metal-oxide-semiconductor (CMOS) imagers for backside illumination are disclosed. In one embodiment, the method may include forming at a front side of a substrate a plurality of high aspect ratio trenches having a predetermined trench depth, and forming at the front side of the substrate a plurality of photodiodes, where each photodiode is adjacent at least one trench. The method may further include forming an oxide layer on inner walls of each trench, removing the oxide layer, filling each trench with a highly doped material, and thinning the substrate from a back side opposite the front side to a predetermined final substrate thickness. In some embodiments, the substrate may have a predetermined doping profile, such as a graded doping profile, that provides a built-in electric field suitable to guide the flow of photogenerated minority carriers towards the front side.
US08530253B2 Method of fabricating flexible display device
A method of fabricating a flexible display device includes: forming a plastic substrate on a carrier substrate, the plastic substrate including an active area and a non-active area surrounding the active area; forming an array element on the carrier substrate, the array element including a plurality of layers and having an average adhesion force among the plurality of layers; forming a first film on the array element, the first film having a first adhesion force; attaching a flexible printed circuit board to the plastic substrate; forming a second film on the first film, the second film having a second adhesion force greater than the first adhesion force; and detaching the plastic substrate from the carrier substrate.
US08530252B2 Method for manufacturing light emitting diode
A method for manufacturing light emitting diodes includes steps of: providing a base have an upper conductive layer and a lower conductive layer on a top face and a bottom face thereof, respectively; forming a plurality of through holes in the base; defining a plurality of grooves to divide the upper and lower conductive layers into discrete strips; forming a connection layer on an inner circumferential face of each hole to connect the opposite strips of the upper and lower conductive layers; filling a supporting layer in an upper portion of each hole; forming a reinforcing layer on the supporting layer and the upper conductive layer; fixing chips on the reinforcing layer and electrically connecting the chips with the strips of the upper conductive layer; forming an encapsulant on the reinforcing layer; and cutting the base into individual LEDs along the holes.
US08530250B2 Light emitting device, resin package, resin-molded body, and methods for manufacturing light emitting device, resin package and resin-molded body
Provided is a simple and low-cost method for manufacturing, in a short time, many light emitting devices wherein adhesiveness between a leadframe and a thermosetting resin composition is high. The method for manufacturing the light emitting device having a resin package (20) wherein the optical reflectivity at a wavelength of 350-800 nm after thermal curing is 70% or more and a resin section (25) and a lead (22) are formed on substantially a same surface on an outer surface (20b) has: a step of sandwiching a leadframe (21) provided with a notched section (21a) by an upper molding die (61) and a lower molding die (62); a step of transfer-molding a thermosetting resin (23) containing a light-reflecting substance (26), in a molding die (60) sandwiched by the upper molding die (61) and the lower molding die (62) and forming a resin-molded body (24) on the leadframe (21); and a step of cutting the resin-molded body (24) and the leadframe (21) along the notched section (21a).
US08530249B2 Middle layer of die structure that comprises a cavity that holds an alkali metal
In one implementation, a chamber is selected that accommodates an array of die structures that comprises one or more cavities. An inner chamber of the chamber is maintained at a first temperature. An alkali metal source of the chamber is maintained at a second temperature greater than the first temperature. An outer chamber of the chamber is maintained at a third temperature greater than the first temperature and the second temperature. The one or more cavities of the array of die structures are filled with a portion of the alkali metal source. The one or more cavities of the array of die structures are sealed to comprise the portion of the alkali metal source.
US08530248B2 Method for placing a component onto a target platform by an apparatus using a probe
The present invention relates generally to assembly techniques. According to the present invention, the alignment and probing techniques to improve the accuracy of component placement in assembly are described. More particularly, the invention includes methods and structures to detect and improve the component placement accuracy on a target platform by incorporating alignment marks on component and reference marks on target platform under various probing techniques. A set of sensors grouped in any array to form a multiple-sensor probe can detect the deviation of displaced components in assembly.
US08530247B2 Control of implant pattern critical dimensions using STI step height offset
A method for semiconductor processing is provided, wherein a semiconductor wafer having undergone polishing is provided. The semiconductor wafer has an active region positioned between one or more moat regions, wherein the one or more moat regions have an oxide disposed therein. A top surface of the active region is recessed from a top surface of the moat region, therein defining a step having a step height associated therewith. A step height is measured, and a photoresist is formed over the semiconductor wafer. A modeled step height is further determined, wherein the modeled step height is based on the measured step height and a desired critical dimension of the photoresist. A dosage of energy is determined for patterning the photoresist, wherein the determination of the dosage of energy is based, at least in part, on the modeled step height. The photoresist is then patterned using the determined dosage of energy.
US08530245B2 Methods and compositions related to acetylocholine receptor conjugates
Disclosed are methods, compositions, and diagnostic kits for detecting acetylcholine receptor (AchR) autoreactive immune cells in a subject. The methods comprise detecting the binding of AChR-conjugate to penpheral blood AChR-specific B cells for diagnosing autoimmune disorders, including Myasthenia gravis (MG), systemic lupus erythematous (SLE), and rheumatoid arthritis (RA). More specifically, the detection is achieved by using flow cytometric assay with Alexa-conjugated AchR.
US08530244B2 Methods and materials for amplification of a signal in an immunoassay
Ultrafine particles are provided having a core region that has a signal amplifying molecule and a shell region that surrounds the core region. The shell region has at least one antibody affixed to its surface that is specific for at least one antigen. Alternatively, the ultrafine particles may entrap the signal amplifying molecule within its matrix and may also have antibodies affixed to its surface for molecular recognition. Ultrafine particles are also provided having a matrix component that includes a signal amplifying molecule and at least one antibody specific for the antigen or biomaterial. The ultrafine particles of the present disclosure may be used in assays for the detection, including quantification, of one or more antigens present in a biological sample.
US08530243B2 Non-scanning SPR system
A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: a) a sensing surface comprising a plurality of areas of interest; b) an illumination sub-system comprising a light source, which illuminates each area of interest on the sensing surface over a range of angles of incidence; c) a detector which responds differently to an intensity of light received by it at different locations; and d) projection optics comprising primary optics and a plurality of secondary elements, the primary optics projecting an image of the illuminated sensing surface onto the secondary elements, which project their received light onto the detector in such a way that it is possible to determine, from the response of the detector, how much light is reflected from each area of interest, as a function of angle of incidence over the range of angles for that area.
US08530236B2 Swellable (meth)acrylate surfaces for culturing cells in chemically defined media
Synthetic surfaces capable of supporting culture of undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a peptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes hydroxyethyl methacrylate, 2-carboxyehylacrylate, and tetra(ethylene glycol)dimethacrylate. The conjugated peptide may include an amino acid sequence of XaanProGlnValThrArgGlyAspValPheThrMetPro, where n is an integer from 0 to 3 and where Xaa is any amino acid. Further, disclosed herein is a swellable (meth)acrylate synthetic surface which can be sterilized by gamma irradiation.
US08530233B2 Expression vector with enhanced gene expression capacity and method for using the same
The present invention provides a novel expression vector which comprises a gene of interest, a nuclear anchoring element, and at least one inverted repeat element, preferably two inverted repeat elements. The expression vector is an episomal vector capable of transfecting a mammalian cell. The present invention further provides a method for enhancing gene expression by transfecting the expression vector to a mammalian cell, preferably a human cell.
US08530232B2 Defective Sindbis viral vector comprising an anti-tumor gene
Disclosed herein are new defective Sindbis viral vectors made from wild type Ar-339 Sindbis virus, with differences in replicase and envelope proteins between JT vectors and consensus Sindbis virus sequences, and also between JT and Ar-339 vectors. Also disclosed are plasmids used for the production of the vectors, methods for producing the vectors, methods for treating mammals suffering from tumors and pharmaceutical formulations for use in the treatment methods.
US08530231B2 Vacuum blood collection tube
A vacuum blood collection tube (100) comprises a bottomed tube (101) composed of a low temperature resistant material that is less susceptible to low temperature fracture when cryopreserved at ultra-low temperature, a stopper (102) having a needle piercing portion (113) composed of a rubber material that can be pierced with a blood collection needle (110), and a cryopreservation cap (103) composed of the low temperature resistant material. Before blood collection, the stopper (102) is attached to the bottomed tube (101) to maintain the reduced pressure state inside the bottomed tube (101). Thus, blood collection by a vacuum blood collection method is possible. After blood collection, the cryopreservation cap (103) is attached to the bottomed tube (101), so that the liquid tight state of the bottomed tube (101) is maintained, and cryopreservation at ultra-low temperature as it is possible. Thus, the collected blood sample can be cryopreserved at ultra-low temperature as it is, without being transferred to another blood storage container, so that effort and burden on an operator can be significantly reduced.
US08530228B2 Integrated versatile and systems preparation of specimens
The invention of Integrated Versatile and Systems Preparation of Specimens relates an open module technology which integrates synchronously the methods of protection, isolation and alteration of specimens into the “One for All” product or kit. The product or kit comprises a core module without or with Plug-in modules and a set of comprehensive protocols which can simultaneously or individually isolate systems biomolecules including DNA/ccfDNA, Large RNA/mRNA/ccfRNA, Small RNA/miRNA/ccfmiRNA, Protein, Lipid, Carbohydrates, and Metabolite versatilely from a vast variety of specimens including solid specimens and liquid specimens. The product or kit can accept new and custom Plug-in modules to expand functions and applications. The product or kit prepares specimens and biomolecules with features and benefits of high quality, easy, fast, no toxicity, safe to user and environment, low demanding, cost-effective, reducing waste, saving nature resources and protecting environment, and leads to a low-carbon and Green economy in preparation of specimens.
US08530227B2 Degradation of nanomaterials
A method of degrading carbon nanomaterials includes mixing the carbon nanomaterials with a composition comprising a peroxide substrate and at least one catalyst selected from the group of an enzyme and an enzyme analog. The peroxide substrate undergoes a reaction in the presence of the catalyst to produce an agent interactive with the nanotubes to degrade the carbon nanomaterials. The peroxide substrate can, for example, be hydrogen peroxide or an organic peroxide.
US08530226B2 Fermentative production of isobutanol with yeast
The invention relates to a yeast cell producing isobutanol, characterized in that the cell has an increased metabolic flow of material from pyruvate and acetolactate, 2,3-dihydroxy isovalerate, 2-ketoisovalerate, isobutyraldehyde to isobutanol, in that at least one of the genes coding the enzymes, which are involved in this conversion, is over-expressed, and without any of said genes being heterologous to said yeast cell, and to a method for the production of isobutanol using yeast cells, comprising the provision of the yeast cells according to the invention, and bringing the yeast cell into contact with a fermentable carbon source.
US08530225B2 Therapeutic agents comprising pro-apoptotic proteins
The present invention relates to targeted killing of a cell utilizing a chimeric polypeptide comprising a cell-specific targeting moiety and a signal transduction pathway factor. In a preferred embodiment, the signal transduction pathway factor is an apoptosis-inducing factor, such as granzyme B, granzyme A, or Bax.
US08530223B2 Method to grow Lawsonia intracellularis bacteria in persistently infected McCoy cells
The present invention pertains to a method to obtain McCoy cells persistently infected with Lawsonia intracellularis bacteria, comprising infecting McCoy cells with Lawsonia intracellularis bacteria, growing the infected McCoy cells in a suitable medium at an oxygen concentration less than 18% to arrive at a culture of McCoy cells infected with Lawsonia intracellularis bacteria, passing at least a part of the said culture to fresh medium, and without adding uninfected McCoy cells to the medium, growing the infected McCoy cells contained in the said at least part in the fresh medium at an oxygen concentration less than 18%, to obtain the persistently infected McCoy cells. The invention also pertains to the use of such persistently infected cells to grow and obtain these bacteria in purified form.
US08530216B2 Polypeptides having alpha-amylase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having alpha-amylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
US08530211B2 Co-fermentation of glucose, xylose and/or cellobiose by yeast
Provided herein are methods of using yeast cells to produce ethanol by contacting a mixture comprising xylose with a Spathaspora yeast cell under conditions suitable to allow the yeast to ferment at least a portion of the xylose to ethanol. The methods allow for efficient ethanol production from hydrolysates derived from lignocellulosic material and sugar mixtures including at least xylose and glucose or xylose, glucose and cellobiose.
US08530210B2 Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
US08530209B2 Method for producing probiotically derived compounds
A method for producing naturally derived beneficial compounds including dispersing a microbiological culture media including at least one live probiotic organism, and at least one nutraceutical and/or at least one nutritive agent in distilled water to form a broth, incubating the broth at a predetermined temperature for a select period of time to induce probiotic activity; halting the probiotic activity, and separating the desired compound from the broth.
US08530205B2 Buffer composition for catalyzing the preparation of calcitriol or calcifediol and method for preparing calcitriol or calcifediol using same
The present invention relates to a buffer composition for promoting production of calcitriol or calcifediol, and a method for producing calcitriol or calcifediol using the same. More particularly, the present invention relates to a buffer composition for promoting production of calcitriol or calcifediol comprising a metallic compound, an organic solvent, cyclodextrin, tris(hydroxymethyl)aminomethane, sodium succinate, sodium chloride, magnesium chloride, and water, and a method for producing calcitriol or calcifediol using the same. In the method for producing calcitiriol or calcifediol, the production yield of calcitriol or calcifediol is high, and the bioconversion is carried out in an enzyme reaction system instead of in a microorganism culture system. Thus, it is not required to maintain a sterile state. Also, the separation/purification following the completion of a biocatalytic reaction can be carried out in a cleaner state than the microorganism culture method. Accordingly, there is an advantage in that a cost required for separation is low and the quality is improved. Furthermore, the buffer composition for promoting production of calcitriol or calcifediol can provide a high productivity of calcitriol or calcifediol.
US08530200B2 Corynebacteria strain for enhancement of 5′-guanosine monophosphate productivity and a method of producing 5′-guanosine monophosphate using the same
Disclosed is a method of producing 5′-guanosine monophosphate using a novel microorganism which has a malate dehydrogenase activity higher than that of a wild-type, thereby showing improved ATP productivity. Also, a novel microorganism is disclosed. The method comprises: culturing the corynebacteria strain which is enhanced in malate dehydrogenase activity over the endogenous activity, thus producing ATP in high yield; producing XMP in the culture; adding to the culture an enzyme or microorganism having XMP amination activity; and obtaining GMP from the culture.
US08530199B2 High speed, high fidelity, high sensitivity nucleic acid detection
Methods, compositions, and kits for nucleic acid detection.
US08530198B2 Detection of nucleic acids and proteins
The invention generally relates to methods for detecting a target nucleic acid and a target protein in a single assay.
US08530195B2 Dyes and labeled molecules
Dimeric and trimeric nucleic acid dyes, and associated systems and methods are provided. Such a dye may form a hairpin-like structure that enables it to stain nucleic acids via a release-on-demand mechanism, for example. Such a dye may have low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, for example. A dye provided herein may be useful in a variety of applications, such as in DNA quantitation in real-time PCR, for example.
US08530188B2 Expression system
A perfect palindrome operator sequence-based protein expression system is provided. The expression system comprises a promoter; and a perfect palindrome operator sequence, wherein the promoter is not T7. The expression system is preferably employed for the production of recombinant proteins by fermentation.
US08530186B2 Method for producing glucuronic acid by glucuronic acid fermentation
The object of the present invention is to provide a microorganism having an excellent ability to specifically oxidize the hydroxymethyl group of glucose, and a method of producing glucuronic acid and/or glucuronolactone by using such a microorganism to directly oxidize glucose, and the invention is directed at a microorganism which produces glucuronic acid directly from glucose and a mutant strain which is capable of specifically oxidizing the hydroxymethyl group of glucose and in which a DNA nucleotide sequence corresponding to 16S rRNA has the nucleotide sequence of SEQ ID NO: 1 in the sequence listing, and the invention is also directed at a method of producing glucuronic acid and/or glucuronolactone by specifically oxidizing the hydroxymethyl group of glucose using the mutant strain, and this invention enables D-glucuronic acid and/or D-glucuronolactone to be produced and furnished easily and safely at a high yield and a low cost.
US08530182B2 Viral protein quantification process and vaccine quality control therewith
A process of quantifying proteins in a complex mixture is provided. The invention has utility in quantifying proteins in a complex preparation of uni- or multivalent commercial or research vaccine preparations.
US08530175B2 Methods for detecting pre-diabetes and diabetes using differential protein glycosylation
Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
US08530174B2 SOGA polynucleotides and polypeptides and uses thereof
The present invention relates to the identification of polynucleotides and polypeptides involved in insulin and adiponectin signaling and regulation of glucose production. The invention further relates to the use of the identified polynucleotides and polypeptides, and inhibitors of the polynucleotides and polypeptides, in the regulation of glucose production and the monitoring and treatment of metabolic disorders such as diabetes.
US08530169B2 Methods for determining oligosaccharide binding
The invention relates to methods for detecting and characterizing enzymatic modifications of oligosaccharides, such as heparan sulfate, and their interaction with binding partners, such as proteins, using an oligosaccharide-binding partner binding assay, such as a gel mobility shift assay. The instant invention relates to a rapid, convenient, sensitive and inexpensive method for identifying or studying oligosaccharide-binding partner interactions, identifying and characterizing structural features on oligosaccharides, identifying and characterizing binding partners, identifying agents capable of interfering with, enhancing, or facilitating the binding of an oligosaccharide to its binding partner, diagnosing conditions associated with altered oligosaccharide-binding partner binding, and generating oligosaccharide libraries and kits therefor.
US08530166B2 Multiplex amplification reaction method for determination of Campylobacter jejuni Penner/capsule type
The inventive method and associated reagents relate to a molecular approach to determining Campylobacter jejuni capsule/Penner types. The invention also relates to a method of identifying Campylobacter jejuni types using the inventive primers in a multiplex PCR assay.
US08530159B2 MiR-29-based methods for the diagnosis and prognosis of acute myeloid leukemia (AML)
The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML). The invention also provides methods of identifying anti-AML agents.
US08530157B2 SNP-dependent end labeling method
Certain embodiments described in this disclosure relate to a method of sample analysis. In certain cases, the method comprises: a) contacting a genomic sample comprising double-stranded genomic DNA with a first restriction endonuclease that recognizes a nucleotide sequence that comprises a SNP site in the double stranded genomic DNA, wherein: i. the restriction endonuclease cleaves the genomic DNA at the sequence regardless of the allele of the SNP present at the SNP site; and ii. cleavage of the sequence by the restriction enzyme creates a 5′ overhang that comprises the SNP site; b) contacting the digested genomic sample with a extension enzyme and a first labeled nucleotide that is used by the extension enzyme to fill in the overhang only if the overhang comprises a first allele of the SNP.
US08530155B2 Methods for diagnosis of common acute lymphoblastic leukemia by determining the level of gene expression
The present invention refers to a method and a kit for diagnosing pediatric common acute leukemia by distinguishing between normal and common acute lymphoblastic leukemic (cALL) cells, wherein the method comprises the step of determining the gene expression of specific genes (markers) referring to this disease and the step of determining whether these genes are up-regulated or down-regulated. The method for determining the gene expression levels can apply hybridization techniques or PCR methods or combinations thereof. The present invention provides new gene markers, which have not been reported in context with cALL and are suitable for the diagnosis of this disease. In addition, the present invention refers to utilizing these targets for the development of targeted therapies employing RNA- and DNA-interference, antibodies, aptamers, anticalins and other small molecules.
US08530152B2 Methods of reducing non-specific interaction in metal nanoparticle assays
The present invention discloses methods of reducing non-specific interactions of interfering species present in a sample in metallic nanoparticle-based assays, thereby increasing the sensitivity of these assays. In particular, the methods entail neutralizing the chemical reactivity of functional groups present in interfering species by addition of a neutralizing agent, such as an alkylating agent or heavy metal ion. The methods are especially useful in assays for the detection of analytes in biological samples. Reagent kits and assay mixtures for the practice of the described methods are also disclosed.
US08530149B2 Dermal micro-organs, methods and apparatuses for producing and using the same
Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for producing the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived, having dimensions selected so as to allow passive diffusion of adequate nutrients and gases to cells of the DMO and diffusion of cellular waste out of the cells so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of waste in the DMO. Some embodiments of the invention provide methods and apparatuses for harvesting the DMO. An apparatus for harvesting the DMO to may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin-related tissue structure. Other embodiments are described and claimed.
US08530148B2 Pattern forming method, resist composition for multiple development used in the pattern forming method, developer for negative development used in the pattern forming method, and rinsing solution for negative development used in the pattern forming method
A pattern forming method, including: (A) coating a substrate with a positive resist composition of which solubility in a positive developer increases and solubility in a negative developer decreases upon irradiation with actinic rays or radiation, so as to form a resist film; (B) exposing the resist film; and (D) developing the resist film with a negative developer; a positive resist composition for multiple development used in the method; a developer for use in the method; and a rinsing solution for negative development used in the method.
US08530147B2 Patterning process
The invention is directed to a method for patterning a material layer. The method comprises steps of forming a first mask layer on the material layer and then patterning the first mask layer. The patterned first mask layer has a pattern therein and a plurality of gaps within the patterns and the gaps expose a portion of the material layer. Further, a second mask layer is formed over the material layer and the second mask layer fills the gaps. An interface layer is formed between the patterned first mask layer and the second mask layer. A portion of the second material layer is removed until the top surface of the interface layer is exposed. The interface layer is removed to expose a portion of the material layer and the material layer is patterned by using the patterned first mask layer and the second mask layer as a mask.
US08530145B2 Method for manufacturing a semiconductor device
In an exposure step, a combination of a first photomask and a second mask is used. The first mask has a real pattern corresponding to the pattern actually formed on the film to be processed, and a dummy pattern added for controlling pattern pitch in the first photomask within a prescribed range; and the second photomask has a pattern isolating a real-pattern-formed region from a dummy-pattern-formed region. In forming the pattern, after forming a film to be processed on a substrate, a first mask is formed on the film to be processed,by lithography, using the first photomask, and a second mask is formed on the film to be processed, by lithography, using the second photomask. Thereafter, the film to be processed is etched and removed using the first and second masks as masks to form the pattern.
US08530140B2 Optical information recording medium and method for manufacturing the same
An optical information recording medium of the present invention includes at least a recording layer (4) that allows information to be recorded thereon and/or reproduced therefrom by being irradiated with a laser beam, and a transmittance adjusting layer (7) in this order from an incident side of the laser beam (30). In the optical information recording medium of the present invention, the transmittance adjusting layer (7) contains Bi, Ti, and O and with a composition of Bi, Ti, and O contained in the transmittance adjusting layer (7) being denoted as BixTiyOz, in atomic number ratio, x, y, and z satisfy 0.07≦x≦0.35, 0.07≦y≦0.28, 0.56≦z≦0.70, and x+y+z=1. Or the transmittance adjusting layer (7) contains Bi2O3 and TiO2, and with a composition of Bi2O3 and TiO2 contained in the transmittance adjusting layer (7) being denoted as (Bi2O3)α(TiO2)β, in molar ratio, α and β satisfy 0.2≦α≦0.7, 0.3≦β≦0.8, and α+β=1.
US08530136B2 Fluoroalcohol containing molecular photoresist materials and processes of use
Phenolic molecular glasses such as calixarenes include at least one fluoroalcohol containing unit. The fluoroalcohol containing molecular glasses can be used in photoresist compositions. Also disclosed are processes for generating a resist image on a substrate using the photoresist composition.
US08530134B2 Process for producing photoresist polymeric compounds
Disclosed is a process for producing a photoresist polymeric compound. The process includes the steps of polymerizing a monomer mixture containing at least one monomer selected from a monomer (a) containing a group capable of leaving with an acid to allow the polymeric compound to be soluble in an alkali, a monomer (b) having a lactone skeleton, and a monomer (c) having a hydroxyl-containing alicyclic skeleton, to give a polymer; passing a solution containing the polymer through a filter including a porous membrane having an anion-exchange group to give a polymer solution; and thereafter passing the polymer solution through a filter including a porous membrane having a cation-exchange group. The polymer solution before passing through the filter including a porous membrane having a cation-exchange group preferably has a content of metals of 1000 ppb by weight or less per the weight of the polymer.
US08530133B2 Preparation of norbornane-based PAC ballasts
Embodiments in accordance with the present invention provide for norbornane-type ballast materials, norbornane-type photoactive compounds derived from such ballast materials and alkali-soluble positive-tone polymer compositions that encompass such norbornane-type photoactive compounds and one of a PBO or PNB resin.
US08530131B2 Toner compositions
Toner particles are provided which may, in embodiments, include a core and a shell, one or both of which may include a polyester gel. The gel in the shell and/or core may prevent a crystalline resin in the core from migrating to the toner surface.
US08530129B2 Image forming method
Provided is an image forming method in which hydrophobized calcium carbonate particles having a number average particle diameter of 30 to 300 nm and hydrophobized strontium titanate particles having a number average particle diameter of 30 to 300 nm are applied to the surface of an image bearing member.
US08530122B2 Foil transferring face forming toner and image forming method
A method for forming an image at least comprising steps of forming an electrostatic latent image by exposing an electrophotographic photoreceptor, forming a foil transferring face by supplying a toner onto the electrophotographic photoreceptor having the electrostatic latent image, transferring the foil transferring face formed on the electrophotographic photoreceptor to a base substance, fixing the foil transferring face transferred on the base substance, supplying a transfer foil to the base substance fixed with the foil transferring face, adhering the transfer foil onto the foil transferring face by heating under a condition of contacting the transfer foil with the foil transferring face; and removing the transfer foil from the base substance while leaving the foil adhered onto the foil transferring face, wherein the toner comprises a binder resin having a softening temperature in the range of from not less than 105° C. to not more than 140° C., and having a molecular weight of not less than 60,000 in a ratio of not less than 10% and not more than 30% based on the total binder resin constituting the toner.
US08530120B2 Method and apparatus for performing pattern reconnection after individual or multipart alignment
A method for patterning a second layer of a work piece in a direct write machine in the manufacturing of a multilayer system-in-package stack. The work piece having a first layer with a plurality of electrical components in the form of dies arbitrarily placed. Each component having connection points where some need to be connected between the components. A first pattern wherein different zones comprising connection points of dies distributed in the first layer are associated with different requirements on alignment. The method comprising the steps of: a. Detecting sacred zones in first pattern that have a high requirement on alignment to selected features of the system-in-package stack or to the placed components; b. Detecting stretch zones of the first pattern that are allowed to have a lower requirement on alignment to other features of the system-in-package stack; c. Transforming the first pattern by calculating adjusted first pattern data comprising transformation of the original circuit pattern such that: i. connection points in adjacent sacred zones are aligned within a pre-settable alignment deviation parameter; and such that ii. deviations between the positions of corresponding connection points in the sacred zones are compensated for in the pattern for connection points of the stretch zones; d. writing a pattern on the layer of the work piece according to the adjusted pattern data. The first pattern may also be simultaneously matched to a second pattern.
US08530119B2 Positive photosensitive resin composition, cured film, protective film, interlayer insulating film, and semiconductor device and display element using the same
A positive photosensitive resin composition includes (A) a polybenzoxazole precursor resin, (B) a photosensitive diazoquinone compound, (C) a hindered phenol antioxidant shown by the following general formula (1), and (D) a phenol compound shown by the following general formula (2). Formula (1) is: wherein R1 represents a hydrogen atom or an organic group having 1 to 4 carbon atoms, a is an integer from 1 to 3, and b is an integer from 1 to 3. Formula (2) is: wherein R2 represents a methylene group or a single bond, c is an integer from 1 to 3, and d is an integer from 1 to 3. A protective film, an interlayer insulating film, and a semiconductor device and a display element using the same are also disclosed.
US08530114B2 Solid oxide fuel cell electrode systems and methods
A solid oxide fuel cell (SOFC) interconnect comprises a metal sheet with an air side and a fuel side in accordance with an embodiment of the present invention. The metal sheet comprises a metallic composite having a matrix. The matrix comprises a first metal. The metal sheet also comprises a plurality of discontinuous, elongated, directional reinforcement wires. The reinforcement wires comprise a second metal that is immiscible in the first metal. An oxidation protection layer is disposed on the air side of the metal sheet.
US08530107B2 Solid oxide fuel cell manifold and corresponding stack
A fuel cell and a fuel cell stack thereof includes separators, each of which includes a sandwiching section for sandwiching an electrolyte electrode assembly, a bridge and a reactant gas supply section, wherein the sandwiching section has a fuel gas channel and an oxygen-containing gas channel, the bridge has a fuel gas supply channel for supplying the fuel gas to the fuel gas channel and an oxygen-containing gas supply channel for supplying the oxygen-containing gas to the oxygen-containing gas channel, and a fuel gas supply passage for supplying the fuel gas to the fuel gas supply channel and an oxygen-containing gas supply passage for supplying the oxygen-containing gas to the oxygen-containing gas supply channel extend through the reactant gas supply section in the stacking direction.
US08530106B2 End cell thermal barrier having variable properties
A fuel cell assembly is disclosed, the fuel cell assembly including a plurality of fuel cell plates arranged in a stack, each fuel cell plate having reactant inlets and outlets and a coolant inlet and outlet; a first terminal plate disposed at a first end of the stack of the fuel cell plates; and a barrier layer disposed between one of the plurality of fuel cell plates and the first terminal plate to provide a thermal barrier therebetween, wherein the barrier layer includes a first portion having a first thermal conductivity and a second portion having a second thermal conductivity.
US08530105B2 Fuel cell system
Provided is a fuel cell system capable of accurately estimating I-V characteristics of a fuel cell. An impedance measurement section measures an impedance of the fuel cell and obtains a voltage drop caused by a direct-current resistance. An air stoichiometry judgment section detects the amount of oxidant gas supplied to the fuel cell and thereby judges whether or not the air stoichiometry ratio is 1 or higher at this time point. An estimated I-V characteristics line creation section determines that the remaining voltage component consists entirely of an activation voltage when the air stoichiometry ratio notified by the air stoichiometry judgment section is 1 or higher, while determining that the remaining voltage drop component includes the combination of the activation overvoltage and voltage drop corresponding to the change in the electromotive voltage when the notified air stoichiometry ratio is below 1.
US08530098B2 Electrolyte for rechargeable lithium battery and rechargeable lithium battery comprising same
Disclosed is an electrolyte for a rechargeable lithium battery including: a first additive having an oxidation potential of 4.1 to 4.6V; a second additive having an oxidation potential of 4.4 to 5.0V; a non-aqueous organic solvent; and a lithium salt.
US08530097B2 Electrode assembly including film-like separator combined with ceramic separator and secondary battery having the same
A secondary battery including an electrode assembly including a positive electrode including a positive electrode active material layer, a negative electrode including a negative electrode active material layer, a separator separating the positive and negative electrodes from each other, and an electrolyte. The separator includes a porous layer comprising a ceramic material and a binder, and a polyolefin-based resin layer. The porous layer has a centerline average roughness (Ra) of 0.3 μm to 1.5 μm, the polyolefin-based resin layer has a porosity of 30% to 60%, and the polyolefin-based resin layer has a compressibility of 4% to 10%.
US08530089B2 Negative electrode, lithium battery employing the same, and method of preparing the negative electrode
A negative electrode, a lithium battery employing the negative electrode, and a method of preparing the negative electrode. The negative electrode includes a current collector, and a negative electrode active material layer disposed on the current collector. The negative electrode active material layer includes: composite negative electrode active material particles comprising tin (Sn), and conductive metal particles. The conductive metal particles form an intermetallic compound with the Sn, and an average particle size of the conductive metal particles is at least 10 μm.
US08530082B2 Method for manufacturing electrode for battery
The invention provides a method for manufacturing a battery electrode having a configuration in which an electrode active material layer including an electrode active material is held on an electrode collector. The method includes a step of mixing the electrode active material with a solvent and preparing an electrode active material paste (step S10), a step of admixing and dispersing microbubbles in the prepared electrode active material paste to obtain a low-density electrode active material paste that has a density lower than that before the admixing (step S20), and a step of coating the electrode collector with the low-density electrode active material paste (step S30).
US08530081B2 Nonaqueous electrolyte secondary battery including positive electrode active material layers having parallel grooves
A nonaqueous electrolyte secondary battery includes an electrode assembly having a high-density positive electrode in which a positive electrode active material layer is formed on at least one surface of a positive electrode current collector, a high-density negative electrode in which a negative electrode active material layer is formed on at least one surface of a negative electrode current collector, and a separator interposed between the positive and negative electrodes, and has a structure in which the electrode assembly is impregnated with a nonaqueous electrolyte, wherein the specific surface area per unit area of the positive electrode active material layer of the positive electrode is 0.5 to 1.0 times the specific surface area per unit area of the negative electrode active material layer of the negative electrode which opposes the positive electrode with the separator sandwiched between them.
US08530078B2 Secondary battery
A secondary battery includes grooves formed in a cap plate into which conducting support members are disposed allowing for the exact connection of a protection circuit board to a predetermined position of the battery. The secondary battery includes: an electrode assembly; a can to house the electrode assembly; a cap assembly; a protection circuit board electrically coupled to an electrode terminal of the cap assembly; and a conducting support member connected to a groove formed in the cap plate and soldered to the protection circuit board. The protection circuit board is electrically and mechanically connected to the groove formed in the cap plate, thereby allowing the protection circuit board to be exactly connected to a predetermined position of the cap plate.
US08530075B2 Water-resistant pouch type secondary cell
Discussed is a pouch type secondary cell with high water-resistance. The pouch type secondary cell includes a positive electrode, a separation layer, and a negative electrode. Here, the sealing unit of the secondary cell includes steps so that the sealing unit has an outer side thinner than an inner side in thickness. The pouch type secondary cell is advantageous in that the manufacture process can be simplified, the water-resistance and sealing property of sealing portions can be further improved, and the manufacture costs can be reduced.
US08530074B2 Rechargeable battery with inductive charge balancing
A battery (1) having at least two serially connected cells (3′, 3″) located one above the other in a stack (2) and having flat electrodes (4, 5), the ends of the stack (2) forming the poles (9, 10) of the battery and the electrodes (4, 5) comprising connecting wires (11, 12) protruding sideways from the stack (2), at least one of the connecting wires (11, 12) of all cells (3′, 3″) being inductively coupled via a common core (13) extending approximately in the longitudinal axis of the stack, and the connecting wires (11, 12) of a first group of cells (3′) being coupled in an inductively opposite fashion to the connecting wires (11, 12) of a second group of cells (3″).
US08530072B2 Lithium secondary battery having porous heat resistant layer between electrodes
A lithium secondary battery having enhanced safety, which includes an electrode group, a non-aqueous electrolyte and a battery can for housing them. The electrode group includes: a positive electrode having a strip-shaped positive electrode current collector and a material mixture layer carried thereon; a negative electrode having a strip-shaped negative electrode current collector and a material mixture layer carried thereon; a separator; and a porous heat resistant layer. The positive and negative electrodes are spirally wound with the separator and the porous heat resistant layer interposed therebetween. An outermost surface of the electrode group includes an exposed portion of either of the positive and negative electrode current collectors. The exposed portion faces an inner surface of the battery can with the separator interposed therebetween, and has opposite polarity to that of the battery can.
US08530070B2 Electronic apparatus
According to one embodiment, an electronic apparatus comprises a casing that includes a battery unit, which features a plurality of battery cells and a case, and a mechanical component. Housing the cells, the case includes a first part to contain at least one cell, a second part to contain at least one cell, and a third part to connect the first part and the second part, the third part including an escape section. The mechanical component is at least partially located in a space formed by the escape section.
US08530069B2 Battery module
A battery module includes a plurality of cells. The battery module also includes a housing configured to substantially enclose the plurality of cells. The battery module further includes a lower tray configured to receive the plurality of cells. The lower tray is located inside the housing adjacent a bottom of the housing and includes a top side and a bottom side. The top side has a plurality of sockets configured to receive the plurality of cells in a closely packed arrangement. The bottom side is configured to define a chamber between the lower tray and the bottom of the housing. The chamber is sealed off from the rest of the battery module and is configured to receive released gas from the plurality of cells.
US08530064B2 Mold-inhibiting method and composition comprising dehydroacetic acid or salt thereof
Disclosed is a method for inhibiting the growth of mold on building materials by application onto and/or incorporation into the building material of a mold-inhibiting composition comprising dehydroacetic acid or a salt thereof and, optionally, an additional fungicidal agent such as a quaternary ammonium compound. A preferred application of the method is the inhibition of mold growth on plasterboard (drywall).
US08530060B2 Light-emitting element including first layer, second layer, third layer and fourth layer
A layer including an organic compound at least includes a layer serving as a light-emitting layer in which a first layer, a second layer, a third layer, and a fourth layer are stacked in that order over an anode. The first layer includes a first light-emitting substance, the second layer includes a second light-emitting substance, the third layer includes a third light-emitting substance, and the fourth layer includes a fourth light-emitting substance. Emission peak wavelengths of the first light-emitting substance and the fourth light-emitting substance are shorter than an emission peak wavelength of the third light-emitting substance, and the emission peak wavelength of the third light-emitting substance is shorter than an emission peak wavelength of the second light-emitting substance. Each of the first layer, the second layer, and the third layer has a hole-transporting property, and the fourth layer has an electron-transporting property.
US08530057B2 Methods for making oxidation resistant polymeric material
The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
US08530054B2 Solar control multilayer film
A multilayer film article is disclosed. The multilayer film article includes an infrared light reflecting multilayer film having alternating layers of a first polymer type and a second polymer type, a hardcoat layer that is the reaction product of a mixture that includes a curable, crosslinkable fluoro-acrylate-containing compound; a curable, crosslinkable non-fluorinated organic compound; infrared light absorbing nanoparticles; and a polymerization initiator. The hardcoat layer being disposed adjacent the multilayer film.
US08530052B2 Carbon nanotube composite preform and method for making the same
A carbon nanotube composite preform includes a substrate and a plurality of carbon nanotubes formed thereon. Each carbon nanotube includes a first end adjacent to the substrate and a second end away from the substrate. Gaps between the second ends of the carbon nanotubes are bigger than gaps between the first ends thereof. The method for making the carbon nanotube composite preform includes the following steps: (a) providing a substrate; (b) forming a plurality of carbon nanotubes (e.g., a carbon nanotube array) on the substrate; (c) placing the carbon nanotubes and the substrate in a solvent for some time; (d) removing the carbon nanotubes and the substrate from the solvent; (e) drying the carbon nanotubes and the substrate to form a carbon nanotube composite preform.
US08530050B2 Wear resistant coating
A wear-resistant component of a carbon seal includes a surface and a coating applied onto the surface. The coating is a chromium carbide-nickel chromium composition constituting between about 75% and about 85% by weight chromium carbide and between about 15% and about 25% by weight nickel chromium. The chromium carbide-nickel chromium composition is applied onto the surface by high velocity oxy-fuel spraying (HVOF).
US08530049B2 Resin-coated metallic pigment comprising a surface modifier at a surface portion, water-based paint containing the same, and method of manufacturing resin-coated metallic pigment
A resin-coated metallic pigment in which a coating layer constituted of a single layer or a plurality of layers is formed on a surface of a base particle, an outermost layer of the coating layer being composed of a resin which is a polymer containing one or more compounds selected from a monomer and an oligomer having two or more polymerizable double bonds as a constituent unit, and a surface portion of the outermost layer being treated with a surface modifier which is a compound having one polymerizable double bond.
US08530046B2 Adhesive sheet for protecting coating film
To provide an adhesive sheet for protecting coating films which is excellent in the adhesion between a coating layer and a composite film, and has weather resistance. The adhesive sheet for protecting coating films is one comprising a base layer and an adhesive layer, and the base layer has a coating layer produced by using the fluoroethylene vinyl ether alternating copolymer having a specific structure on one surface of a composite film containing an acrylic polymer and a urethane polymer. It is preferable that the coating layer is cross-linked with a composite film and has cross-linked points.
US08530042B2 Component surface with three-dimensional surface texture and method for the creation of a component surface with three-dimensional surface texture
This invention relates to a component surface (side section 1a), in particular a vehicle surface, with a three-dimensional surface texture. This invention further relates to a method for the creation of a component surface (side section 1a), in particular a vehicle surface, with a three-dimensional surface texture. To keep the effort and expense required for the achievement of a three-dimensional surface texture low, the invention teaches that a film is glued to the component surface (side section 1a), which film has been provided prior to the gluing with a plurality of coats of paint, each using the screen printing process, which in their totality form a three-dimensional surface texture.
US08530037B2 Window trim apparatus and methods for making and using same
Window trim apparatus are provided that include scored grooves made by methods other than extrusion. Also provided are methods and apparatus for manufacturing and using same.
US08530034B2 Roofing products including granules with reflective coating
A roofing product with a higher reflectivity is provided having a roofing material, and fine granules adhered to the roofing materials that are double-coated with a coating having a white pigment. A top white coating composition can be applied to the granules after the granules are applied to a roofing material. Further, a process of manufacturing a roofing product is provided, where fine granules that are double-coated with a coating having a white pigment are applied to a roofing material, and a top coating composition is then applied to the fine granules.
US08530031B2 Evacuatable container
A container (10) having a valve flap (20) which is movable between a closed position, whereat it is seated on the seating area (18) to close an evacuation port (16), and an opened position, whereat it is unseated from the seating area (18) to open the evacuation port (16). A label structure (26) includes a film layer (28) forming a seat platform on which a seating area (18) is located and/or a film layer (30) forming a flap platform on which the valve flap (20) is located. A plurality of label structures (26) can be efficiently and economically mass-produced by a label-manufacturer and then supplied to the container-manufacturer for incorporation into the containers (10).
US08530030B2 Honeycomb structure
There is disclosed a honeycomb structure including a honeycomb structure section including: porous partition walls to divide and form a plurality of cells which extend from one end surface to the other end surface and become through channels of a fluid; and an outer peripheral wall positioned in an outermost periphery. The partition walls and the outer peripheral wall contain silicon carbide particles as an aggregate, and silicon as a binder to bind the silicon carbide particles, thicknesses of the partition walls are from 50 to 200 μm, a cell density is from 50 to 150 cells/cm2, an average particle diameter of silicon carbide as the aggregate is from 3 to 40 μm, and a volume resistivity at 400° C. is from 1 to 40 Ωcm.
US08530022B2 Article or component of a medical and technical nature for affixing a medical article or part thereof to skin, provided with a releasable protection layer
An article (1) of a medical and technical nature intended to be affixed to skin, or a component for affixing a medical article or part thereof to skin, which article or component comprises a layer of carrier material (2) that has a layer (3) of a soft skin-friendly adhesive on one side, and a protection layer (4) that protects the adhesive layer before use of the article or component and is affixed to the adhesive layer in such a way that it is releasable. According to the invention, the protection layer (4) is provided with a pattern of projections (6) on the side facing towards the adhesive layer (3) and a reinforcing layer (5) is arranged on the layer of carrier material (2), on the opposite side to the side that has the layer of soft skin-friendly adhesive, in such a way that it can be removed.
US08530018B2 Ion exchanger and method of producing the same
[Problems] To provide an ion exchanger having excellent electric properties, a low electric resistance, excellent mechanical strength and, at the same time, having excellent contamination resistance.[Means for Solution] An ion exchanger comprises a melt-extrusion-formed body of a resin composition containing a granular ion-exchange resin and a low-melting polyolefin resin having a melting point of not higher than 170° C., the melt-extrusion-formed body: (a) containing the granular ion-exchange resin at a ratio of not less than 30% by weight but less than 50% by weight, and the low-melting polyolefin resin in an amount of more than 100 parts by weight but not more than 150 parts by weight per 100 parts by weight of the granular ion-exchange resin; (b) having a melt index in a range of 1 to 5 g/10 min. as measured at 190° C.; and (c) having a water content of not less than 30%.
US08530017B2 Method for preparing styrene-butadiene copolymer using reactive emulsifier and styrene-butadiene copolymer prepared by the same
Provided is a method for preparing a styrene-butadiene copolymer having improved silica affinity through introduction of a novel reactive emulsifier. The styrene-butadiene copolymer prepared according to the disclosed method has superior affinity for thereby and thus has superior processability and tensile properties and remarkably improved dynamic properties. Therefore, when the styrene-butadiene copolymer according to the present invention is used as a tire tread material, it can greatly improve its physical properties.
US08530013B2 Fuel hose
A fuel hose (10) includes a laminated layer structure including: an intermediate layer (12) containing polyvinyl alcohol and/or an ethylene-vinylalcohol copolymer; an inner layer (11) disposed on an inner periphery of the intermediate layer; and an outer layer (13) disposed on an outer periphery of the intermediate layer and containing a rubber. The inner layer (11) includes: a first component containing nitrile rubber; and cross-linked chains formed of carbon-carbon single bond, and is directly laminated to the intermediate layer (12).
US08530011B2 Insulating glass unit with crack-resistant low-emissivity suspended film
A low-e insulating glass unit has a suspended, coated IR reflecting polymer sheet under tension, e.g. from heat shrinkage. The polymer sheet is coated with a multilayer stack of dielectric and metallic layers, including at least one silver layer deposited upon a zinc oxide seed layer that is at most 15 nm thickness. The use of zinc oxide ensures good seeding for high quality silver layer growth, thereby providing low emissivity. The thinness of the zinc oxide ensures that it resists cracking when the polymer sheet is tensioned.
US08530007B2 Liquid crystal display and method of manufacturing the same
A liquid crystal display includes a first substrate, a second substrate, and a liquid crystal layer. The first substrate includes a first insulating substrate, in which a pixel area is defined, a gate line formed on the first insulating substrate, a data line crossing the gate line, and a thin film transistor connected to the gate line and the data line. The second substrate is opposite to the first substrate. The liquid crystal layer is interposed between the first and second substrates and includes a liquid crystal composition with a nematic-isotropic phase transition temperature (Tni) of 79° C. or above.
US08530004B2 Polymeric electret film and method of manufacturing the same
Disclosed is a polymeric electret film as well as the method of manufacturing the same. The polymeric electret film comprises a polytetrafluoroethylene film and an electrode layer. The polytetrafluoroethylene film includes a porous layer, which has a porous structure. The porous structure has a pore diameter ranging between 0.01 μm and 5.0 μm and has a porosity ranging between 20% and 95%. The polytetrafluoroethylene film has a thickness ranging between 1 μm and 50 μm, and is preferably made of expanded porous polytetrafluoroethylene. The polymeric electret film has a surface potential ranging between 0.1 V and 1000 V.
US08529999B2 Thermal barrier coating application processes
A process of coating an article includes the steps of (1) forming a layer of a ceramic based compound on an article; (2) providing a solution containing a metal as a particulate having a diameter of about 10 nanometers to about 1000 nanometers and present in an amount of about 25 percent to about 50 percent by volume of the solution; (3) contacting the ceramic based compound layer with the solution; (4) drying the article; and (5) optionally repeating steps (3) and (4).
US08529992B2 Method and apparatus for coating ducts
The present disclosure includes a method of applying a coating material to an air duct including inserting a first end of a supply line including a spray head and a camera through a first opening in the air duct; initiating flow of coating material to the spray head through the supply line; pulling the supply line and the attached spray head and camera so that the spray head deposits coating material onto the interior surfaces of the duct while capturing the deposition of coating material using the camera. Using the process and apparatus of the present disclosure provides for the coating of the inside of a air duct while being able to observe and monitor the deposition of coating material in order to ensure that the coating material is applied consistently and evenly along the length of the air duct.
US08529989B2 Method for manufacturing magnetic recording layer having two or more layers
The present invention relates to a method for manufacturing a perpendicular magnetic recording medium including a nonmagnetic substrate, and at least a soft magnetic under layer, an orientation control layer, a magnetic recording layer constituted of two or more layers and a protective layer formed on the nonmagnetic substrate, the method including a step of forming a first magnetic recording layer having a granular structure constituted of ferromagnetic crystal grains and crystal grain boundaries made of a nonmagnetic oxide or nitride on the nonmagnetic substrate side, a step of forming a second magnetic recording layer constituted only of ferromagnetic crystal grains, a step of forming a surface unevenness control layer for decreasing surface unevenness of the first magnetic recording layer located between the first magnetic recording layer and the second magnetic recording layer, and a step of heating the nonmagnetic substrate so as to decrease a surface roughness Ra of the second magnetic recording layer to less than 2 nm. The present invention also relates to a magnetic recording and reproducing apparatus using the magnetic recording medium.
US08529984B2 Method of producing an ombré´ finish for materials
Methods of producing an ombré finish for materials may comprise applying a stain to the surface of a material in a first concentration toward a first part of said surface and in a second concentration toward a second part of said surface, blending said stain from said first part to said second part to create a gradual transition in concentration, and sealing said surface. Said methods may also comprise applying a stain substantially uniformly to the surface of a material, removing said stain from said surface so as to create a gradual transition in concentration of said stain, and sealing said surface. Said methods may further comprise the steps of comparing the color of said material to a target color and toning said material until said color of said material matches said target color.
US08529978B2 Tea leaves for extraction of a green tea beverage
Provided is a tea leaves for extraction of a low-caffeine green tea beverage, which is not susceptible to folding or browning during storage, and which enables the extraction of a green tea beverage which can be enjoyed hot or cold. Specifically provided is a tea leaves for extraction of a green tea beverage having a caffeine content with respect to the total mass of the dried leaves that falls within the range of 0.2 to 2.5 mass %, and the relation between the ratio of the mass content of theanine to the entire mass of dried leaves X (%) and the mass ratio of the content of monosaccharides to the fiber content Y satisfies the following condition: −0.007X+0.024≦Y≦−0.011X+0.039.
US08529973B2 Coffee composition and method of making a three-layered coffee drink
The disclosure relates to a coffee composition, in particular, an instant coffee composition which can provide a three-layered coffee drink in one step. The coffee composition having coffee, a foaming agent, a protein source and at least 1.3 wt % (based on the total weight of the composition) of a kappa-carrageenan, iota-carrageenan or mixture thereof. The disclosure also relates to a method for the preparation of such a composition and such a drink.
US08529972B2 Process to extract drinking water from a plant
There is provided a process to extract drinking water from a plant, which includes the steps of: a) filtrating collected plant sap to separate plant water content from concentrated plant extract; and b) disinfecting the separated plant water content to remove or inactivate microorganism to obtain plant drinking water. and the process may further include step c) bottling the plant drinking water. There is also provided plant drinking water prepared according to the process and a liquid beverage containing plant drinking water and nutriments and/or dietary minerals extracted from plants and optionally any flavoring ingredients.
US08529971B2 Packaging of a stack of confectionery pellets and the like
Packaging of a stack of confectionery pellets (12) comprises a tubular pack (30) formed from a flexible wrapper (32) and a re-closable cap member (34) mounted to one end of pack. The cap member has a base affixed to a side wall of the pack (30) and a scoop (40) attached to the base for movement between closed and open positions. The scoop (40) is shaped to act as a receptacle for holding a pellet (12) dispensed from the pack when in the open position. The wrapper (32) has a line of weakness (61) extending around all or part of the end wall region and during manufacture an inside surface of the scoop (40) is bonded to the end wall region. When the scoop (40) is first opened, the wrapper (32) tears along the line of weakness to create an opening in the pack (30) through which pellets (12) can be dispensed. A method of manufacturing the packaging is also disclosed.
US08529968B2 Decontaminating composition having simultaneously bactericidal, fungicidal and virocidal properties, methods for obtaining and using said composition
The invention concerns a decontaminating composition having simultaneously bactericidal, fungicidal and virocidal properties, comprising as active components eugenol, eugenol acetate, vanillin and carvacrol, characterized in that said active constituents are present in the following percentages by weight: at least about 12% eugenol, at least about 3% eugenol acetate, at least about 0.1% vanillin and at least about 0.5% carvacrol. Said decontaminating composition can be used as liquid or solid soaps. It can also impregnate in liquid form fabrics and nonwoven fabrics such as garments for medical use, bed sheets, slip covers, surgery drape, dressings and gauze such as those applied to the skin of serious burn victims.
US08529962B2 Method of making demineralized bone particles
Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.
US08529959B2 Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
US08529954B2 Composition based on gamma-hydroxybutyric acid
The present invention relates to a granule of gamma-hydroxybutyric acid or of one of its pharmaceutically acceptable salts, characterized in that it comprises a solid core on which the gamma-hydroxybutyric acid or one of its salts is supported.
US08529953B2 Process for production of spherical microparticles comprising tamsulosin hydrochloride
The present invention provides a method for producing spherical fine particles containing tamsulosin hydrochloride, the method includes the steps of: (1) mixing and stirring tamsulosin hydrochloride (a), microcrystalline cellulose (b), and water until a mixture of the component (a) and the component (b) is uniformly impregnated with the water; (2) granulating the mixture obtained in step (1) using an stirring granulator whose peripheral speed is set to be 5.5 to 9.0 m/s; and (3) drying the granules obtained in step (2). The present invention also provides spherical fine particles obtained according to the method, coated fine particles obtained by applying a coating to the spherical fine particles, and an orally disintegrating tablet containing the coated fine particles.
US08529951B1 Elastogenic cues and methods for using same
Disclosed are elastogenic cues that can be utilized to encourage growth and development of elastin-containing cellular constructs. The elastogenic cues include hyaluronan fragments and oligomers, optionally in conjunction with growth factors and/or a source of copper ions. The elastogenic cues can up-regulate elastin matrix synthesis and by vascular smooth muscle cells. In addition to encouraging synthesis of elastin in a cellular matrix and organization into elastic fibers, the elastogenic cues can also stabilize the formed ECM matrix through suppression of elastin-laminin receptor (ELR). In addition, the elastogenic cues can inhibit cell hyper-proliferation (e.g., hyperplasia) common in inflammatory vascular disease.
US08529950B2 Magnesium system and use thereof in the cosmetics industry
A magnesium-based system suitable for use in skincare comprises (a) a first magnesium source in the form of a progressive-release oral tablet exhibiting in vitro, after 2h in 0.1N HCl medium, a rate of dissolution (δ) of the magnesium contained therein of less than or equal to 60% by weight relative to the total weight of the Mg provided by the first magnesium source, and (b) a second magnesium source in a topical preparation. A method for treating skin for stress, fatigue or skin barrier deficiencies, as well as for stratum corneum hydration, includes orally and topically administering magnesium sources (a) and (b), respectively.
US08529946B2 Rapidly disintegrating antihistamine formulation
The invention relates to a rapidly disintegrating oral antihistamine dosage formulation and method of preparing the rapidly disintegrating formulation wherein the formulation is designed to dissolve in the buccal cavity of the patient.
US08529929B2 Drug delivery system
It is a main object of the present invention to provide a drug delivery system in which drugs can be changed or which can be recharged with drugs, which continuously delivers drugs at effective concentrations to local lesional sites in a body and allows the use of drugs for which it has thus far been difficult to achieve effective local concentrations for a variety of reasons and drugs which have been difficult to use due to adverse effects on tissues that are not sites of action. The present invention provides a drug delivery system comprising an indwelling medical device on which a biocompatible material having target molecules on its surface has been coated, and target-recognizing nanocarriers (e.g., bio-nanocapsules, liposomes, liposome preparations, and nanoparticles) in which drugs are encapsulated and which have target-recognizing molecules capable of specifically binding to the target molecules.
US08529928B2 Biomimetic polymers and uses thereof
Biodegradable polymers incorporating biomolecules and methods of their use are provided. Certain aspects provide biomolecules crosslinked with diglycidyl esters. The disclosed compositions have numerous applications including cellular regeneration, wound healing, and cellular differentiation.
US08529927B2 Alpha-2 agonist polymeric drug delivery systems
Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, including reduction of an elevated intraocular pressure.
US08529926B2 Pesticidal compositions
To provide a formulation composition which improves the controlling effect of an anthranilamide compound against pests. A pesticide composition which is a concentrated composition containing an anthranilamide compound as a pesticidal active ingredient, a dispersant and a hydrophilic organic solvent, characterized in that when the composition is diluted with water, the anthranilamide compound precipitates as solid particles in water.
US08529923B2 Cosmetic composition based on substantially hemispherical particles
Disclosed is a cosmetic composition including, in a cosmetically acceptable medium, the combination of (a) a sufficient amount of uncoated substantially hemispherical PMMA particles and (b) a sufficient amount of substantially hemispherical PMMA particles coated with optionally treated metal oxide. It also relates to its uses in caring for or making up the skin.
US08529915B2 (R)-(-)-1,2-propanediol compositions and methods
Short-chain 2- to 3-carbon alcohols are used as solvents for cooling agents in the preparation of topical therapeutic and cosmetic formulations. Some of these alcohols, especially ethanol, inhibit the ability of the cooling agent to activate its target receptor. In one embodiment of this invention, (R)-1,2-propanediol is used as an alcoholic solvent for the topical delivery of cooling agents to biological surfaces. This propanediol enantiomer has a minimum inhibitory effect on cooling with respect to standard 2- to 3-carbon alcoholic solvents, and functions to substantially protect the agent's cooling activity from inhibition when in the presence of a short-chain alcohol.
US08529914B2 Bioactive dose having containing a material for modulating pH of a bodily fluid to help or hinder absorption of a bioactive
A bioactive dose for delivering a bioactive agent to a mammal, includes a solid bioactive dosage unit containing at least one bioactive agent and a rapid release coating provided on at least one outer surface of the solid bioactive dosage unit, the rapid release coating containing a material having a property of rapidly modulating a pH of bodily fluids in which the material comes in contact in a direction towards an ideal absorptive pH or towards an ideal pH to hinder absorption of the at least one bioactive agent given the pKa that least at one bioactive agent.
US08529913B2 Immunogenic compositions for Streptococcus pyogenes
The invention includes a GAS antigen, GAS 40, which is particularly suitable for use either alone or in combinations with additional GAS antigens, such as GAS 117, GAS 130, GAS 277, GAS 236, GAS 40, GAS 389, GAS 504, GAS 509, GAS 366, GAS 159, GAS 217, GAS 309, GAS 372, GAS 039, GAS 042, GAS 058, GAS 290, GAS 511, GAS 533, GAS 527, GAS 294, GAS 253, GAS 529, GAS 045, GAS 095, GAS 193, GAS 137, GAS 084, GAS 384, GAS 202, and GAS 057.
US08529910B2 Enterococcus antigens
The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from E. faecalis, methods for isolating such antigens and specific uses thereof.
US08529906B2 Compositions for inducing immune responses
The invention provides, inter alia, immunogenic compositions comprising a first antigen, at least two adjuvants, wherein a first adjuvant comprises a polymer derived from poly(lactides) and/or poly(lactide-co-glycolides), and wherein a second adjuvant comprises an imidazoquinoline, wherein said first antigen is encapsulated within, adsorbed or conjugated to, co-lyophilized or mixed with said first adjuvant, and a pharmaceutically acceptable excipient, wherein said composition elicits a cellular immune response when administered to a vertebrate subject. The invention also provides methods of producing immunogenic compositions, methods for producing a cytotoxic-T lymphocyte (CTL) response in a vertebrate subject, and methods of immunization.
US08529902B2 Human monoclonal antibodies against CD20
Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
US08529900B2 Methods for the treatment, the prognostic assessment and the staging of non-small cell lung cancer
The present invention relates to methods for the treatment, the prognosis and the diagnosis of non-small cell lung cancer.
US08529897B2 Inflammation-regulating compositions and methods
The various embodiments provide a composition that provides local control over inflammation. The composition localizes the activities of the cytokine-neutralizing antibodies to the site of inflammation through covalent attachment to hydrophilic matrices. The various embodiments including a hydrophilic polymer, a ligand binding moiety covalently attached to the polymer, and optionally, a cellular adhesion peptide covalently attached to the polymer. The hydrophilic polymer may be a glycosaminoglycan such as hyaluronan. The cellular adhesion peptide may be a linear RGD peptide sequence covalently attached to the polymer. The ligand binding moiety may be a monoclonal antibody covalently attached to the polymer. The antibody may be selected from the group consisting of an anti-IL-1β, an anti-IL-6, an anti-TNF-α, and combinations thereof. The polymer functions as a substrate or matrix for cell migration and tissue regeneration. The RGD peptide functions to promote cellular proliferation, migration and attachment to the polymer. The monoclonal antibody functions to inhibit the inflammatory response.
US08529891B2 Inhibitors of extracellular HSP90
The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention relates to the use of molecules inhibiting extracellular Hsp90 function for the manufacture of a medicament for the treatment or prevention of invasion and/or metastatic potential of cancer cells.
US08529890B2 Composition for the administration of polymeric drugs
Provided are improvements in and relating to pharmaceutical compositions for oral administration of polymeric biological drug substances and to methods of treatment using such compositions. In particular, an oral and/or mucosal pharmaceutical composition is provided, said composition comprising an enteric-coated drug substance, and also comprising an enteric-coated oligouronate, wherein said drug substance is a polymeric biological drug substance.
US08529887B2 Probiotics in a pre- and/or post surgical environment
The present invention relates generally to the field of nutrition, more particularly to the use of probiotics in nutrition. In particular the present invention relates to the use of a probiotic or of a mixture of probiotics in the manufacture of a nutritional composition or a medicament to act the colon in a pre- or post surgical environment.
US08529885B2 AAV vectors for in vivo gene therapy of rheumatoid arthritis
The present invention relates to the field of adeno-associated virus (AAV) based gene therapy, in particular in vivo gene therapy, of rheumatoid arthritis (RA). The invention provides recombinant AAV virions being highly efficient in delivering genes encoding therapeutic proteins to the arthritic joints, and method for using such virions in in vivo gene therapy.
US08529879B2 Epithelium-improving agent
It is intended to provide an epithelium improving agent which improves the epithelial functions of various organs and, therefore, is usable in growing melanin-pigmented hair, relieving inflammatory symptoms in gingivitis and paradentitis, treating and relieving cold syndrome and bronchial asthma and, moreover, restoring sexual sensibility. An epithelium improving agent which comprises coenzyme Q10, cysteine, vitamins A, C and E and a skin extract of a rabbit inoculated with a vaccinia virus as the main components. In the case of treating gingivitis, paradentitis, cold syndrome and bronchial asthma, loratadine is further added. To an epithelium improving agent which is to be used in stimulating hair growth or restoring sexual sensibility, liquid paraffin and a hydrophilic ointment is further added to give a cream. Thus, the above problem can be solved.
US08529876B2 Pigment mixtures for cosmetics
Provided is a pigment composition comprising a first and second effect pigments, wherein the composition has a hue comparable to carmine but does not comprise carmine.
US08529874B2 Peptide imaging agents
The present invention relates to labelled cMet binding peptides suitable for optical imaging in vivo. The peptides are labelled with an optical reporter group suitable for imaging in the red to near-infrared region. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods, especially of use in the detection, staging, diagnosis, monitoring of disease progression or monitoring of treatment of colorectal cancer (CRC).
US08529873B2 SE-72/AS-72 generator system based on Se extraction/ As reextraction
The preparation of a 72Se/72As radioisotope generator involves forming an acidic aqueous solution of an irradiated alkali bromide target such as a NaBr target, oxidizing soluble bromide in the solution to elemental bromine, removing the elemental bromine, evaporating the resulting solution to a residue, removing hydrogen chloride from the residue, forming an acidic aqueous solution of the residue, adding a chelator that selectively forms a chelation complex with selenium, and extracting the chelation complex from the acidic aqueous solution into an organic phase. As the 72Se generates 72As in the organic phase, the 72As may be extracted repeatedly from the organic phase with an aqueous acid solution.
US08529871B2 Method for preventing nasolacrimal duct obstruction
The invention is directed to a method for preventing nasolacrimal duct obstruction (NLDO) in a patient receiving high dose radioactive iodine for treatment of cancer. The method includes administering an effective amount of perchlorate anion to the eyes of the patient.
US08529862B2 Method for preparing single walled carbon nanotubes from a metal layer
Methods of preparing single walled carbon nanotubes are provided. An arrangement comprising one or more layers of fullerene in contact with one side of a metal layer and a solid carbon source in contact with the other side of metal layer is prepared. The fullerene/metal layer/solid carbon source arrangement is then heated to a temperature below where the fullerenes sublime. Single walled carbon nanotubes are grown on the fullerene side of the metal layer.
US08529859B2 Method for fabricating apatite crystals and ceramics
The present invention provides a method of crystallizing Yb:C-FAP [Yb3+:Ca5(PO4)3F], by dissolving the Yb:C-FAP in an acidic solution, following by neutralizing the solution. The present invention also provides a method of forming crystalline Yb:C-FAP by dissolving the component ingredients in an acidic solution, followed by forming a supersaturated solution.
US08529857B2 Retention of amines in the removal of acid gases by means of amine absorption media
A method for removing acid gases from a fluid stream comprises a) treating the fluid stream in an absorption zone with an absorption medium which comprises an aqueous solution of at least one amine, conducting the treated fluid stream through at least two scrubbing zones and treating it with a non-acidic aqueous phase in order to transfer entrained amine and/or entrained amine decomposition products at least in part to the aqueous phase, wherein aqueous phase is recycled via at least one scrubbing zone and aqueous phase is conducted through at least one scrubbing zone without recycling. The method permits efficient retention of amines from the treated fluid streams.
US08529856B2 Method and apparatus to sequester CO2 gas
The present invention is directed to methods to sequester oxides of carbon to prevent them from entering the atmosphere as gases. More specifically, this invention is directed to methods of chemical reactions and process to decompose carbon oxides by combustion of a metal fuel with carbon oxides using a regeneration process to recover the metal fuel. The process can optionally and beneficially be coupled to other useful chemical processes for the industrial purpose of sequestering carbon oxides into useful commercial chemicals and elements like carbon, chlorine, and sodium bicarbonate.
US08529853B2 ZrOx, Ce-ZrOx, Ce-Zr-REOx as host matrices for redox active cations for low temperature, hydrothermally durable and poison resistant SCR catalysts
The present invention relates to application of catalysts for the Selective Catalytic Reduction of oxides of Nitrogen using N-containing reductant. The catalysts are characterized as phase pure lattice oxide materials into which catalytically active cations are incorporated at high levels of dispersion such that conventional analysis reveals a highly phase pure material. The materials are further characterized by high activity, hydrothermal durability and poison tolerance in the intended application.
US08529852B2 Flue-gas purification and reclamation system and method thereof
A flue-gas purification system includes a flue-gas cycling system, a reactor, and an absorbent adding system having at least a catalytic absorbent, wherein the catalytic absorbent is being gasified for reacting with the flue-gas in the reactor in a homogenous gas-gas phase reacting manner. Therefore, the purification system has fast reaction rate between the pollutants of the flue-gas and the catalytic absorbent, which is preferably ammonia, to efficiently remove pollutants, so as to effectively purify the flue-gas.
US08529850B2 Compositions and methods of using a ketoxime in a metal solvent
Provided are methods using a ketoxime in metal extraction. One aspect of the invention relates to a method for the recovery of metal from a metal-containing aqueous solution at an elevated temperature using a ketoxime. Another aspect relates to a method of separating iron/copper using a specific ketoxime. Aldoximes may also be added to the reagent compositions used in these methods.
US08529849B2 Heat transfer in SMR tubes
An improved reactor tube which includes a reactor tube, wherein the reactor tube is at least partially filled with at least one porous media catalyst, and at least one shape memory alloy element located within the reactor tube, wherein; at a first temperature, the shape memory alloy element has a first configuration, at a second temperature, the shape memory alloy element has a second configuration is provided.
US08529845B2 Brine maker
Provided herein is an admixing apparatus and system that in various arrangements may be utilized to produce deicing solutions including salt brines. To facilitate cleaning of the interior of the device, a mixing hopper is utilized that includes a side access opening that allows for readily accessing the interior of the hopper and removing any sediment that has accumulated herein.
US08529844B2 Apparatus for producing trichlorosilane and method for producing trichlorosilane
An apparatus for producing trichlorosilane includes: a decomposing furnace, a heating unit heating the inside of the decomposing furnace, a raw material supplying tube for guiding polymer and hydrogen chloride to be guided to the inner bottom portion of the decomposing furnace, and a gas discharge tube for discharging reaction gas from the top of the reaction chamber provided between the outer peripheral surface of the raw material supplying tube and the inner peripheral surface of the decomposing furnace, a fin, which guides a fluid mixture of the polymer and the hydrogen chloride supplied from the lower end opening of the raw material supplying tube to be agitated and rise upward in the reaction chamber, and is formed integrally with at least one of the outer peripheral surface of the raw material supplying tube and the inner peripheral surface of the decomposing furnace.
US08529841B2 Method for managing treatment of a particular health condition via a phone device
A method for managing treatment of a particular health condition afflicting a patient through the use of a mobile phone device which includes a health management program stored in the mobile phone device that prompts a user for entry of health condition data, including patient physiological data, subjective patient health condition data, and medication delivery data, compiles the health condition data into an accumulated data summary, and transmits the data summary from the mobile phone device to a second processing unit through a communication port. A drop-down list related to subjective symptoms is provided, which includes stress and depression. A touch screen is provided for a graphical user interface. The health management program also provides prompts for the entry of diet data, and further displays drop-down lists related to daily activities and alerts for medication delivery.
US08529840B2 Method for collecting patient health condition management data at a central server system
A method for managing treatment of a particular health condition afflicting a patient through connection of a patient local processing device with a remote web server system. The patient local processing device receives patient health condition data, such as subjective patient symptoms and analyte levels, compiles the data into summaries to correlate subjective symptoms to analyte levels. The web server automatically provides patient reports to a healthcare provider.
US08529838B2 Method for managing treatment of a patient health condition with a PDA based system
A method for managing treatment of a particular health condition afflicting a patient through the use of a PDA which includes a health management program stored in the PDA that prompts a user for entry of health condition data, including patient physiological data, subjective patient health condition data, and medication delivery data, compiles the health condition data into an accumulated data summary, and transmits the data summary from the PDA to a second processing unit through a communication port. A drop-down list related to subjective symptoms is provided, which includes stress and depression. A touch screen is provided for a graphical user interface. The health management program also provides prompts for the entry of diet data, and further displays drop-down lists related to daily activities and alerts for medication delivery.
US08529837B2 System and method for detecting specific binding reactions using magnetic labels
A system and method for detecting specific binding reactions using magnetic labels.
US08529833B2 Method and apparatus for disinfecting enclosed spaces
A method and apparatus disinfects enclosed spaces by the dispersal of aerosols ionized alternately with negative and positive electrostatic polarity.
US08529831B1 System and method for air purification using an enhanced multi-functional coating based on in-situ photocatalytic oxidation and ozonation
A system for air purification based on in-situ photocatalytic oxidation and ozonation includes a single multi-functional Ti02-based coating having photocatalytic activity for oxidation in the presence of a sufficient ozone supply and UV irradiation to synergistically oxidize gaseous pollutants at ambient conditions. Also disclosed is a method for removing gaseous pollutants using ozone and UV irradiation to simultaneously activate the photocatalytic oxidation in the presence of the Ti02-based coating to remove up to about 84% of the gaseous pollutants within 5 minutes.
US08529826B2 Manufacturing method of honeycomb structure
There is provided a manufacturing method of a honeycomb structure, comprising: forming kneaded clay containing a cordierite forming raw material formed by mixing talc having an average particle diameter of 0.1 to 40 μm, kaolin having an average particle diameter of 0.1 to 20 μm, an alumina source raw material having an average particle diameter of 0.05 to 10 μm, and a silica having an average particle diameter of 0.1 to 20 μm, a binder, a surface active agent, water, and a hygroscopic resin having an average particle diameter of two to 200 μm after water absorption and a water absorption magnification of two to 100 magnifications into honeycomb shape to fabricate a honeycomb formed body; and firing the honeycomb formed body to obtain a honeycomb structure whose porosity is less than 40%.
US08529823B2 Imprint lithography
A method of determining an offset between an imprint template and a substrate using an alignment grating on the imprint template and an alignment grating on the substrate is disclosed. The method includes bringing the imprint template alignment grating and the substrate alignment grating sufficiently close together such that they form a composite grating, directing an alignment radiation beam at the composite grating while modulating the relative position of the imprint template and the substrate, detecting the intensity of alignment radiation which is reflected from the composite grating, and determining the offset by analyzing modulation of the detected intensity.
US08529822B2 Method for manufacturing a flexible optical plate, product and backlight module made therewith
A method for manufacturing a flexible optical plate includes steps of: (A) positioning a metallic mask on a surface of a mother substrate; (B) irradiating a carbon dioxide laser beam through the metallic mask to form cavities on the surface of the mother substrate; (C) coating a polymer material on the surface of the mother substrate to fill the cavities; and (D) drying the coated polymer material to form the flexible optical plate, the flexible optical plate having a substrate on the surface of the mother substrate and microstructures protruding from the substrate and each corresponding to one of the cavities.
US08529821B2 Polymeric compositions and filled TPO articles having improved aesthetics
The present invention relates to filled polymeric compositions, such as filled TPO compositions, having improved aesthetics, and to polymeric masterbatches which may be used to prepare the improved filled TPO compositions. The present invention also relates to processes for preparing the filled TPO compositions which eliminates a compounding step. The polymeric compositions of the present invention include at least about 5 weight percent inorganic filler based on the total weight of the polymeric composition; a high viscosity polypropylene impact copolymer having a highly crystalline portion, wherein the highly crystalline portion is present from about 20 weight percent to about 90 weight percent of the high viscosity polypropylene impact copolymer, and a xylene soluble portion, wherein the xylene soluble portion is present from about 10 weight percent to about 80 weight percent of the high viscosity polypropylene impact copolymer and has a z-average molecular weight greater than about 1,500,000 Da, a number average molecular weight less than about 100,000 Da, and a polydispersity index greater than about 5; and a low viscosity substantially linear ethylene polymer having a polydispersity index less than about 3.5, and a melt flow rate greater than about 40 g/10 min as measured according to ASTM D-1238 at 190° C./2.16 kg.
US08529819B2 Wound closure material
Articles are provided having no orientation or a multi-directional orientation. Such articles may be in the form of films, ribbons, sheets, and/or tapes and may be utilized as buttresses with a surgical stapling apparatus or as reinforcing means for suture lines.
US08529816B2 Mold frames and cavities for making dimpled golf balls
Universal mold frames for producing multi-piece golf balls are provided. The mold frames include lower and upper frame plates having locator pins that are inserted into corresponding locator slots in the mold cavities. The eccentric pin layout of the frame plates and corresponding slots in the cavities means the cavities can be fitted easily and aligned in the frame plates. The interior surfaces of the mold cavities define a specific dimple pattern such as icosahedron or tetrahedron-based patterns. The mold frames can accommodate cavities having different dimple patterns. A castable liquid polymer, for example, polyurethane is dispensed into the mold cavities, which are then pressed together to form the spherical cover for the ball.
US08529808B2 Nanoporous polymer foams
Process for the production of nanoporous polymer foams, comprising the stages a) loading of a single-phase, thermoplastic polymer melt with a gas under a pressure and at a temperature at which the gas is in the supercritical state, b) heating of the laden polymer melt to a temperature which lies in the range from 40° C. under to 40° C. over the glass transition temperature of the unladen polymer melt determinable by means of DSC according to DIN-ISO 11357-2 at a heating rate of 20 K/min, c) depressurization of the polymer melt loaded in stage a) and heated in stage b) with a depressurization rate in the range from 15,000 to 200,000 MPa/sec, and the nanoporous polymer foams with a cell count in the range from 1,000 to 100,000 cells/mm and a density in the range from 10 to 500 kg/m3 obtainable according to the process.
US08529807B2 Method for neutralizing or recycling carrier materials for film-like coatings
The present invention relates to methods by which to produce sheet-like, wafer-like or film-like forms of drugs, confectionary, other food, cosmetics and the like for oral application or intake. The present invention is more particularly directed to the thermal treatment of carrier materials used in the production of such sheet-like, wafer-like or film-like forms. The thermal treatment removes contaminating or undesired substances from the carrier material.
US08529806B2 Process for producing regenerated elastic roller
There is provided a process for producing a regenerated elastic roller which can be again used for the formation of high-quality electrophotographic images by sufficiently relaxing a compression set of the elastic roller having the compression set caused in an elastic layer in usage. The process for producing a regenerated elastic roller includes a step of heating an elastic roller having a conductive mandrel and an elastic layer and having a compression set caused in the elastic layer, in a cylindrical mold to thermally expand the elastic layer and to cause a surface of the elastic roller to contact an inner wall of the cylindrical mold.
US08529804B2 Method for manufacturing a modified optical fiber
A modified optical fiber comprises one Surface Light Field Emulation (s-LiFE) segment, comprising a core; a cladding; and multiple controlled nanoscale diffusion centers to emit light through the side of the optical fibers. Optionally, the modified optical fiber has a coating. The nanoscale diffusion centers are physical geometric patterns or composition patterns in the cladding or the coating. The s-LiFE optical fiber is a member of an illumination system further comprising a light source. The method of making of said s-LiFE optical fiber comprises a fiber spooning step.
US08529803B2 Curable coloring composition, color filter and method for producing same, and quinophthalone dye
A curable coloring composition includes a quinophthalone dye of Formula (1). A color filter employing the composition, a method for producing the color filter, and a quinophthalone dye of Formula (2) are also described. The curable coloring composition and color filter have good color hue, high transmittance properties, high light fastness and heat fastness, and excellent stability over time and solvent resistance.
US08529801B2 Negative active material for rechargeable lithium battery, and negative electrode for rechargeable lithium battery, and rechargeable lithium battery including same
A negative active material of a negative electrode of a rechargeable lithium battery, the negative active material including a metallic active material core and a polymer, having a tensile strength of at least 40 MPa, coated on particles of the metallic active material. The polymer controls the volumetric expansion of the negative active material and enhances the cycle-life characteristics of the battery.
US08529796B2 Charge transport compositions and electronic devices made with such compositions
The present invention relates to charge transport compositions. The invention further relates to electronic devices in which there is at least one active layer comprising such charge transport compositions.
US08529791B2 Green-emitting, garnet-based phosphors in general and backlighting applications
Disclosed herein are green-emitting, garnet-based phosphors having the formula (Lu1-a-b-cYaTbbAc)3(Al1-dBd)5(O1-eCe)12:Ce,Eu, where A is selected from the group consisting of Mg, Sr, Ca, and Ba; B is selected from the group consisting of Ga and In; C is selected from the group consisting of F, Cl, and Br; and 0≦a≦1; 0≦b≦1; 0
US08529790B2 White light emitting organogel and process thereof
The present invention provides white light emitting materials. The invention further provides a process for the preparation of white light emitting organogels using the concept of molecular self-assembly and partial energy transfer. The donor acceptor type molecules on coassembly and subsequent irradiation with suitable wavelength light produce white light. On irradiation, partial transfer of the excitation energy from the donor to the acceptor takes place, resulting a broad emission covering the entire range from 400-700 nm to give bright white light emission with CIE coordinates of (0.31, 0.35).
US08529788B2 Pearlescent composition
A pearly luster composition containing a fatty acid glycol ester and water, and further containing any one selected from the group consisting of (1) a polyoxyalkylene nonionic surfactant and a fatty acid contained in an amount of from 0.3 to 3% by weight of the pearly luster composition, (2) a polyoxyalkylene nonionic surfactant and an aliphatic alcohol contained in an amount of from 0.3 to 3% by weight of the pearly luster composition, (3) a fatty acid monoglyceride contained in an amount of from 0.3 to 3% by weight of the pearly luster composition, and (4) an aliphatic ether contained in an amount of from 0.3 to 3% by weight of the pearly luster composition, as a crystallization additive. The pearly luster composition of the present invention is suitably used for shampoos, conditioners, body shampoos, liquid detergents, and the like.
US08529787B2 Colloidal silica containing silica secondary particles having bent structure and/or branched structure, and method for producing same
This invention provides a dense, high-purity colloidal silica containing silica secondary particles having a branched and/or bent structure, and a production method thereof. Specifically, this invention provides a method for producing a colloidal silica, comprising the steps of 1) preparing a mother liquid containing an alkali catalyst and water, and having a pH of 9 to 12; and 2) adding a hydrolysis liquid obtained by hydrolysis of an alkyl silicate to the mother liquid, wherein the step of adding the hydrolysis liquid to the mother liquid sequentially comprises A) step 1 of adding the hydrolysis liquid until the pH of the resulting liquid mixture becomes less than 7; B) step 2 of adding an aqueous alkali solution until the pH of the liquid mixture becomes 7 or more; and C) step 3 of adding the hydrolysis liquid while maintaining the pH of the liquid mixture at 7 or more, and a colloidal silica containing silica secondary particles having a branched and/or bent structure, obtained by this method.
US08529786B2 Phosphorus-containing stabilizers for fluoroolefins
The present disclosure relates to compositions comprising at least one fluoroolefin and an effective amount of a stabilizer comprising at least one phosphorus-containing compound selected from the group consisting of thiophosphates, butylated triphenylphosphorothionates, and organophosphates. The stabilized compositions may be useful in cooling apparatus, such as refrigeration, air-conditioning, chillers and heat pumps, as well as in applications as foam blowing agents, solvents, aerosol propellants, fire extinguishants, and sterilants.
US08529785B2 Metal oxide
Provided is a piezoelectric material excellent in piezoelectricity. The piezoelectric material includes a perovskite-type complex oxide represented by the following General Formula (1). A(ZnxTi(1-x))yM(1-y)O3  (1) wherein A represents at least one kind of element containing at least a Bi element and selected from a trivalent metal element; M represents at least one kind of element of Fe, Al, Sc, Mn, Y, Ga, and Yb; x represents a numerical value satisfying 0.4≦x≦0.6; and y represents a numerical value satisfying 0.1≦y≦0.9.
US08529784B2 Electrically-conductive and semi-conductive films
Methods and apparatuses for generating electrically-conductive and/or semi-conductive films, and more specifically, methods and apparatuses for generating conductive and/or semi-conductive films having nanoscale features are provided. In one embodiment, an electrically-conductive or semi-conductive film (e.g., a gold layer of less than 50 nanometer thickness) is provided on a substrate (e.g., a poly(dimethylsiloxane) (PDMS) stamp). The substrate may optionally include patterns or features having raised and recessed portions. A first portion of the film may be removed from the substrate, e.g., by methods such as physically contacting the first portion of the film with a surface to which the first portion preferentially adheres. This process can leave a second portion of the film remaining on the substrate. In some embodiments, the second portion includes at least one region having a dimension substantially parallel to a portion of the substrate i.e., of less than 50 nanometers. The second portion of the film may be used to establish electrical communication with an electrical contact. Advantageously, electrically-conductive and/or semi-conductive films having nanoscale features can be fabricated over large areas (e.g., areas greater than 1 cm2) in a single step.
US08529782B1 Microstructure manufacturing method
A microstructure manufacturing method includes (a) generating first light including an interference fringe by crossing two laser beams, (b) forming a denatured region and a non-denatured region on an object having thermal non-linearity by applying the first light onto the object, so that the denatured region and the non-denatured region are disposed so as to correspond to a period of the interference fringe of the first light, and (c) etching the object so that the denatured region or the non-denatured region is selectively eliminated.
US08529777B2 Method of making a mask, method of patterning by using this mask and method of manufacturing a micro-device
The present invention relates to a method of making a mask for patterning a thin film. The method includes a step of forming an inorganic material, which is resolvable into alkali solution, on a substrate; a step of forming the inorganic material in a predetermined pattern; and a step of narrowing the inorganic material with the alkali solution to form the mask.
US08529767B2 Method for determining the percentage of recirculation in a fistula and/or cardiopulmonary recirculation relative to the total fistula recirculation and cardiopulmonary recirculation
The method according to the invention and the apparatus according to the invention are characterized in that the substitution rate QS is modified by a predefined amount upstream or downstream of the dialyzer or filter while the flow rate QFM of the liquid withdrawn through the dialyzer membrane is modified. The blood volume RBV(t) or a variable correlated with the blood volume, e.g. the hematocrit Hct(t), is determined before and after modifying the substitution rate or the flow rate of the liquid withdrawn through the dialyzer or filter membrane in order to calculate fistula recirculation RA. In addition, the total recirculation R is determined. The percentage of fistula recirculation (RA) and/or cardiopulmonary recirculation (RCP) relative to the total recirculation is calculated from the determined fistula recirculation (RA) and the sum R of fistula recirculation (RA) and cardiopulmonary recirculation (RCP).
US08529762B2 Spiral wound membrane element product water tube with external flow grooves
The disclosed product water tube is for use with a filter element having a filter membrane. The product water tube has a tube wall with a plurality of apertures formed therein to allow permeate from the filter membrane to pass through the tube wall and into a center portion of the tube. The tube wall has an outer surface having a pattern of ridges and channels that conduct the permeate across the outer surface of the tube to the apertures.
US08529761B2 Central pumping and energy recovery in a reverse osmosis system
A reverse osmosis system includes a plurality of feed pumps each having a feed pump input and a feed pump output, an input manifold in fluid communication with the feed pump inputs and a membrane feed manifold in fluid communication with the feed pump output. The system also includes a plurality of membrane chambers each in fluid communication with the membrane feed manifold and generating a permeate output and a brine output, each brine output in fluid communication with a brine manifold. The system further includes a plurality of booster devices each having a turbine portion with a turbine input in fluid communication with the brine manifold and a pump portion having a booster device pump input and a booster device pump output, each booster device pump output in fluid communication with the membrane feed manifold. The system includes a pump input manifold in fluid communication with the booster device pump input. The system also includes a medium pressure pump in fluid communication with the input manifold and the pump input manifold.
US08529760B1 Optical separator and method for separating particles suspended in a fluid
A device and method of using same, wherein the device includes a collimated light source operable to generate a collimated light source beam, the collimated light source beam comprising a beam cross-section. The device further includes at least one body defining a first channel in a first plane, the first channel comprising a first channel cross-section, the first channel being oriented to receive the collimated light source beam such that the beam cross-section completely overlaps the first channel cross-section. Optionally, the body defines a second channel in a second plane orthogonal to the first plane, wherein the body defines a third channel in a third plane orthogonal to the first plane.
US08529759B2 Electric deionized water production apparatus
An electric deionized water production apparatus in which a direct current field is applied to a deionizing chamber packed with an ion-exchange material such that ions to be discharged are allowed to migrate in the direction identical or opposite to the direction of the water flow in the ion-exchange material, whereby ionic impurities adsorbed in the ion-exchange material are discharged from the system, the ion-exchange material being a mixture of a monolith-shaped organic porous ion-exchange material and ion-exchange resin particles. The electric deionized water production apparatus has a simple structure that can reduce material cost, process cost, and assembly cost, capable of accelerating migration of the adsorbed ionic impurities to facilitate discharge of the adsorbed ions and free from a deflected flow due to swelling or shrinkage accompanying an ion-exchanging reaction, and from poor contact with an ion-exchange membrane.
US08529756B2 Separating sand from fluids produced by a well
A settling system may be used to separate and/or remove solid particles, such as sand, from fluids produced by wells. The container of the settling system may be cleaned without need for manned-entry.
US08529754B2 Catalytic conversion process for producing more diesel and propylene
The present invention relates to a catalytic conversion process for producing more diesel and propylene, comprising contacting the feedstock oil with a catalyst having a relatively homogeneous activity in a reactor, wherein the reaction temperature, weight hourly space velocity and weight ratio of the catalyst/feedstock oil are sufficient to obtain a reaction product containing from 12 to 60% by weight of a fluid catalytic cracking gas oil relative to the weight of the feedstock oil; the fluid catalytic cracking gas oil is fed into the fluid catalytic cracking gas oil treatment device for further processing. Catalytic cracking, hydrogenation, solvent extraction, hydrocracking and process for producing more diesel are organically combined together, and hydrocarbons such as alkanes, alkyl side chains in the feedstock for catalysis are selectively cracked and isomerized.
US08529753B2 Combined process for hydrotreating and catalytic cracking of residue
Disclosed is a combined process for hydrotreating and catalytic cracking of residue, wherein the residue, catalytic cracking heavy cycle oil with acidic solid impurity being removed, optional distillate oil and adistillate of catalytic cracking slurry oil from which the acidic solid impurity is removed are fed into residue hydrotreating unit, the hydrogenated residue obtained and optional vacuum gas oil are fed into catalytic cracking unit to obtain various products; the catalytic cracking heavy cycle oil from which the acidic solid impurity is removed is circulated to the residue hydrotreating unit; the catalytic cracking slurry oil is separated by distilling, the distillate of the catalytic cracking slurry oil after removing off the acidic solid impurity is circulated to the residue hydrotreating unit. This process makes the residue hydrotreating and catalytic cracking being combined together more effectively such that it is not only able to improve product quality of the residue hydrotreating, elongate operation cycle of the residue hydrotreating unit, but also increases the yield of the hydrogenated diesel oil and catalytic cracking light oil, and decreases coking quantity of the catalytic cracking.
US08529750B2 Apparatus and method for detecting biomolecules
Provided are an apparatus and method for detecting biomolecules. The apparatus includes a FET having a substrate, a source electrode, a drain electrode, a channel region between the source and drain electrodes, and probe molecules fixed to the channel region, wherein the source and drain electrodes are separated on the substrate, a microfluid supplier selectively supplying one of a reference buffer solution of low ionic concentration and a reaction solution of high ionic concentration containing target molecules, to the channel region of the FET to which the probe molecules are fixed, and a biomolecule detector detecting the target molecules by measuring a first current value of the channel region of the FET, and a second current value of the channel region of the FET to which the target molecules and the probe molecules that bind to each other in the reaction solution of high ionic concentration are fixed.
US08529746B2 Methods for producing textured electrode based energy storage device
This method enables the use of nanowire or nano-textured forms of Polyaniline and other conductive polymers in energy storage components. The delicate nature of these very high surface area materials are preserved during the continuous electrochemical synthesis, drying, solvent application and physical assembly. The invention also relates to a negative electrode that is comprised of etched, lithiated aluminum that is safer and lighter weight than conventional carbon based lithium-ion negative electrodes. The invention provides for improved methods for making negative and positive electrodes and for energy storage devices containing them. The invention provides sufficient stability in organic solvent and electrolyte solutions, where the prior art processes commonly fail. The invention further provides stability during repetitive charge and discharge. The invention also provides for novel microstructure protecting support membranes to be used in an energy storage device.
US08529744B2 Enrichment of nucleic acid targets
Methods and apparatus providing improved fidelity and specificity when separating nucleic acids from a sample, but without need for amplification. In particular, using the disclosed methods, it is possible to isolate a variant nucleic acid (i.e., a mutation) from a non-target nucleic acid (i.e., a wild-type) when the variant is present in the original sample at a much lower concentration than the non-target, e.g., 1:10,000, without substantial loss of the variant.
US08529742B2 Electrochemical sensor with controlled variation of working electrode
An electrochemical sensor includes a dielectric substrate and a conductive layer formed on a surface of the substrate. The conductive layer includes a working electrode, an electrode lead and a connecting arm connecting the working electrode to the electrode lead. A dielectric layer is positioned over the conductive layer. The dielectric layer has an aperture exposing the working electrode and a portion of the connecting arm. The working electrode, electrode lead and connecting arm may be formed by laser ablation technique to provide precise working electrode sensor parameters.
US08529739B2 Indium oxide-cerium oxide based sputtering target, transparent electroconductive film, and process for producing a transparent electroconductive film
A transparent conductive film for constructing a transparent electrode that is free from the generation of residue, etc. by etching with a weak acid (for example, organic acid). Further, there is provided a sputtering target for producing the transparent conductive film. In particular, there is provided a sputtering target composed of indium oxide and cerium oxide, characterized in that in the observation of crystal peaks by X-ray diffractometry, the presence of peaks ascribed to indium oxide and cerium oxide is observed, and that in the EPMA measurement, the diameter of cerium oxide particles dispersed in indium oxide is measured as being ≦5 μm. A transparent conductive film is formed by a sputtering technique with the use of this sputtering target. This transparent conductive film is substantially free from the generation of residue, etc. by etching with a weak acid (for example, organic acid).
US08529738B2 In situ plating and etching of materials covered with a surface film
Systems and methods for plating and/or etching of hard-to-plate metals are provided. The systems and methods are designed to overcome the deleterious effect of superficial coating or oxide layers that interfere with the plating or etching of certain metal substrates. The systems and methods involve in situ removal of coating materials from the surfaces of the metal substrates while the substrates are either submerged in plating or etching solutions, or are positioned in a proximate enclosure just prior to submersion in the plating or etching solutions. Further, the substrates can be in contact with a suitable patterning mask to obtain patterned oxide-free regions for plating or etching. This in situ removal of coating layers may be achieved by pulse heating or photoablation of the substrate and the inhibiting coating layers. Electrical energy or laser light energy may be used for this purpose. Additionally or alternatively, the coating materials may be removed by mechanical means.
US08529729B2 Plasma processing chamber component having adaptive thermal conductor
An assembly comprises a component of a plasma process chamber, a thermal source and a polymer composite therebetween exhibiting a phase transition between a high-thermal conductivity phase and a low-thermal conductivity phase. The temperature-induced phase change polymer can be used to maintain the temperature of the component at a high or low temperature during multi-step plasma etching processes.
US08529726B2 Method for producing hollow product
A method for producing a hollow product comprises a film arrangement step wherein a film is arranged on a fiber layer; a molded body arrangement step wherein a molded body having a recess is arranged on the film after the film after the film arrangement step in such a manner that the opening of the recess faces the film; the gas present between the fiber layer and the film is evacuated; the gas present between the film and the molded body is evacuated; a film-molded body bonding step wherein the film and the molded body are bonded together after the step of gas evacuation from between the film and the molded body; and a fiber layer-film bonding step wherein the fiber layer and the film are bonded together after the step of gas evacuation from between the fiber layer and the film.
US08529725B2 Printed absorbent article components for a uniform appearance
A method is presented for manufacturing a disposable absorbent article having multiple components including selecting a first material appropriate for use as an outer cover; producing a chassis including the outer cover, the outer cover including an outer cover central region having an outer cover central region appearance; selecting a second material appropriate for use as an elastic panel, wherein the second material is different from the first material; and producing a first elastic panel having a first elastic panel central region. The method also includes printing the first elastic panel central region with a first elastic panel printed graphic; and attaching the first elastic panel to the chassis, wherein the selecting and printing are performed such that the first elastic panel central region gives the appearance of being substantially similar to the outer cover central region appearance.
US08529724B2 Anodic bonding of silicon carbide to glass
MEMS and microelectronic devices and fabrication methods feature providing a first material including a glass, providing a second material having an elastic modulus greater than the elastic modulus of silicon, causing the second material to have a surface with a RMS surface roughness of greater than 0.001 μm and less than approximately 0.15 μm, contacting the surface of the second material to a surface of the first material, and applying a voltage between the first and second materials to cause an anodic bond to form.
US08529711B2 Induction heat treatment method, induction heat treatment installation and induction-heat-treated product
An induction heat treatment method with which temperature control is enabled, condition setting is easy, and the quality of a treatment object can be stabilized includes: a data acquiring step of heating and quench-hardening a sample of the treatment object to thereby acquire process data; a storing step of storing the process data; a checking step of checking the power supply output transition data and the quenching timing data as to validity based on the temperature transition data stored in the storing step; and a mass production step of performing heat treatment of the treatment object in accordance with the power supply output transition data and the quenching timing data stored in the storing step and checked as to validity in the checking step.
US08529706B2 Method and apparatus for cleaning a mouthguard
A device for cleaning and storing a mouthguard, including two main chambers shaped for receiving and holding a mouthguard. One of the main chambers has a sealable lid for retaining disinfecting liquid and the other main chamber has vents to allow water to drain away, and to allow air flow for drying the mouthguard.
US08529703B2 Cleaning agent, cleaning method and cleaning apparatus
A cleaning agent or a rinsing agent having no flash point which comprises a chlorine-free fluorine-containing compound have a vapor pressure at 20° C. of 1.33×103 Pa or more and one or more components having a vapor pressure at 20° C. less than 1.33×103 Pa and optionally an additive such as an antioxidant; a method for cleaning which comprises cleaning with the cleaning agent and rinsing and/or vapor cleaning utilizing a vapor being generated by boiling the cleaning agent or a condensate thereof; a method for separating a soil which comprises contacting a cleaning agent in a cleaning tank with a condensate of the vapor of the cleaning agent in a soil separating tank, to thereby continuously separate and remove a soil contained in the cleaning agent; and a cleaning apparatus.
US08529695B2 Method for manufacturing a silicon wafer
Silicon wafer manufacturing method including cleaning polycrystalline silicon with dissolved ozone aqueous solution, cleaning the polycrystalline silicon with fluoric acid or mixed acid of fluoric acid and nitric acid, rinsing the polycrystalline silicon with ultra pure water, melting the rinsed polycrystalline silicon and pulling a single crystal silicon ingot from the molten silicon liquid at a solidification ratio of 0.9 or less, making the pulled single crystal silicon ingot into block-shaped or grain-shaped single crystal silicon, cleaning with dissolved ozone aqueous solution, cleaning with fluoric acid or mixed acid of fluoric acid and nitric acid, rinsing the single crystal silicon with ultra pure water, remelting and pulling a single crystal silicon ingot at a solidification of 0.9 or less, and forming a silicon wafer out of the single crystal silicon ingot.
US08529691B2 Joint filler composition
A joint filler composition may include 100 parts by mass of a base material, 1 to 20 parts by mass of inorganic hollow particles, and 3 to 20 parts by mass of a mineral having a chain structure or a layer structure.
US08529690B1 Process for controlling a crystal form of alite in portland cement clinker
The present invention relates to a process of controlling crystal form of Alite in Portland cement clinker, wherein the said Portland cement clinker is thermally treated in order to change the crystal form of Alite in Portland cement clinker, so as to improve performance of resulting Portland cement clinker. The said process of present invention is easy and feasible.
US08529689B2 Cementitious compositions and related systems and methods
Provided are cementitious compositions and related systems and methods. The cementitious compositions, or admixtures, according to the present invention generally comprise gypsum, a first alkaline component and glass. The admixture may further comprise fly ash, which is preferably obtained as a waste by-product from a coal-burning power plant. A method according to the present invention comprises an initial step of analyzing or receiving an analysis of a fly ash sample. Based at least in part on the analysis of the fly ash sample, a mix rate may be selected and an initial admixture can be formulated, which, when added to the fly ash sample, creates an alternative or additive to Portland cement for use in concrete, for example.
US08529686B2 Dis-azo compound and oil ink and electrowetting displays comprising the same
The present invention provides a dis-azo compound and an oil ink comprising the same. The dis-azo compound is represented by the following formula (I): wherein R1 represents substituted or unsubstituted C4˜C16 alkyl, and R2 and R3 independently represent substituted or unsubstituted C1˜C6 alkyl. Besides, the present invention also provides an electrowetting display using the oil ink.
US08529680B2 Compositions for CMP of semiconductor materials
The invention provides a composition for chemical-mechanical polishing. The composition comprises an abrasive, a first metal rate polishing modifier agent, a second metal rate polishing modifier agent, and a liquid carrier. In one embodiment, the first metal rate polishing modifier agent has a standard reduction potential less than 0.34 V relative to a standard hydrogen electrode, and the second metal rate polishing modifier agent has a standard reduction potential greater than 0.34 V relative to a standard hydrogen electrode. In other embodiments, the first and second metal rate polishing modifier agents are different oxidizing agents.
US08529676B2 Fuel vapor adsorption canister
A canister for trapping a fuel vapor vaporized in a fuel tank has a casing defining an adsorption chamber therein, an adsorbent capable of adsorbing the fuel vapor and filled in the adsorption chamber and a flow regulation plate disposed in the casing. The casing has a fuel introducing port configured to introduce the fuel vapor from the fuel tank into the adsorption chamber, and an air communicating port communicating the adsorption chamber with the atmosphere. The air communicating port is formed on a side surface of the casing extending in a direction of gravitational force. The flow regulation plate disposed at an end of the adsorption chamber near the air communicating port and has an opening configured to communicate the adsorption chamber with the air communicating port. The opening is positioned above the air communicating port in the direction of gravitational force.
US08529672B2 Chromatography oven with heat exchange and method of use
Methods and systems for cooling gas chromatography ovens that comprise a housing having a fluid entry and a sleeve positioned within the housing to provide a fluid gap between the inner surface of the housing and the outer surface of the sleeve, where the sleeve is coupled to the fluid entry, and where a cooling fluid from the fluid entry traverses the inner layer of the sleeve and thereafter the outer layer of the sleeve via the fluid gap. In one embodiment, the housing includes at least one adjustable fluid exit, and the fluid gap is in fluid communications with the fluid exit(s). The fluid entry and the sleeve can be concentric, and the sleeve can include a heating element. A fan can be positioned to drive the cooling fluid from the fluid entry.
US08529671B2 Electret webs with charge-enhancing additives
Electret webs are presented which include a blend of a thermoplastic resin and a charge additive. The charge additives include ester-substituted and amide-substituted trianilino triazine materials. The webs prepared from the blends may be in the form of films or non-woven fibrous webs. Non-woven microfiber webs are useful as filtration media.
US08529664B2 Removal of a target gas from a mixture of gases by swing adsorption with use of a turboexpander
The separation of a target gas selected from a high pressure gas mixture containing said target gas as well as a product gas using a swing adsorption process unit. A turboexpander is used upstream of the swing adsorber to reduce the pressure of the high pressure gas mixture. A compressor is optionally used downstream of the swing adsorber to increase the pressure of the target gas-containing stream for injecting into a subterranean formation.
US08529662B2 Removal of heavy hydrocarbons from gas mixtures containing heavy hydrocarbons and methane
A process for the separation of one or more heavy hydrocarbon gases from a gas mixture containing heavy hydrocarbon gas components and methane. The process is conducted in swing adsorption apparatus containing adsorbent contactor having a plurality of flow channels and wherein 20 volume percent or less of the open pore volume of the contactors, is in the mesopore and macropore range.
US08529660B2 Control device and control method for a vehicle compressed air preparation device
A control device for a compressed air preparation device of a vehicle outputs output signals for adjusting feed phases and regeneration phases of the compressed air preparation device. A compressor feeds compressed air via an air dryer having a desiccant into a compressed air reservoir in a feed phase, and compressed air is passed out of the compressed air reservoir through the air dryer for drying the desiccant in a regeneration phase. The control device adjusts the regeneration phases depending on a current or future engine load and/or a current or future consumption of compressed air by the vehicle. In overrun phases, the desiccant can be excessively dried to a low moisture level in order to save fuel in later travel segments. Route-optimized regeneration of the desiccant as a function of engine load and/or utilization phases can also be effected.
US08529652B2 Soot particle filter
A soot particle filter according to the invention can be particularly used in motor vehicles or heating systems using liquid and solid fuels. The device is particularly characterized by a time controlled variable regeneration of the soot particle storage (10) and soot particle burn-off. The device is in particular catalytic. The device comprises at least one filter housing (2) having an input (3), an output (4) and a filter element (6). A soot particle storage chamber (10) is further provided in the filter housing (2) and comprises an access (19) that is particularly angled and tapered toward the inside. The inner chamber of the soot particle storage (10) is lined with precious metal discs (11). Said discs have holes, are angled and/or corrugated. The precious metal discs and/or a precious metal mesh (11) are at least partially catalytically coated. An ignition device (12) is arranged in the filter housing (12), for example a glow plug and/or a glow filament.
US08529651B2 Process for the production of metal oxide and metalloid oxide dispersions
Process for the production of an aqueous dispersion of pyrogenically produced metal oxide and metalloid oxide powders with a BET surface area of between 5 and 600 m2/g, with a metal oxide or metalloid oxide content in the dispersion of between 5 and 25 wt. %, comprising the following steps: water, which is optionally adjusted to pH values of between 2 and 4 by adding acids, is circulated from a receiving vessel via a rotor/stator machine, and metal oxide or metalloid oxide powder is introduced, using a feed device, into the shear zone between the slots in the rotor teeth and the stator slots, continuously or discontinuously and with the rotor/stator machine running, in a quantity such that a predispersion with a solids content of between 20 and 40 wt. % results, and, after all the metal oxide powder or metalloid oxide powder has been added, the feed device closes and shearing continues in such a way that the shear rate is in the range of between 10000 and 40000 s−1, and then, by dilution, the predispersion is adjusted to the desired solids content of the dispersion while maintaining the dispersing conditions.
US08529649B2 Methods of fabricating a polycrystalline diamond structure
In an embodiment, a method of fabricating a polycrystalline diamond structure includes forming an assembly including a sintered polycrystalline diamond body positioned between an aluminum-containing layer and a substrate. The method further includes subjecting the assembly to a high-pressure/high-temperature process to form the polycrystalline diamond structure including a polycrystalline diamond table bonded to the substrate.
US08529648B2 Mixing and feeding aqueous solution of alkali metal salt and particles of sulfur-containing carbonaceous fuel for gasification
A process of producing a combustible gas from a solid sulfur-containing carbonaceous fuel is provided. In the process, an aqueous solution is provided. A solute of the solution is a carbonate salt of an alkali metal. Particles of the fuel and the aqueous solution are mixed (26) to form a mixture. The mixture is fed into a gasifier (22) that contains molten salts of the alkali metal. The fuel is partially combusted in the gasifier to produce the combustible gas. At least a portion of the carbonate salt in the aqueous solution may be recovered (24) from a molten sulfide salt. The molten sulfide salt may be taken from the molten salts in the gasifier (22).
US08529640B1 Dyeing composite and method of dyeing fiber
A dyeing composite comprising: a polymer core containing a magnetic material; and at least one dye arranged so as to surround the polymer core, as well as a method of preparing the dyeing composite, are described. The dyeing composite is used in a method of dyeing a fiber.
US08529636B2 Emulsion dyeing composition containing at least one phospholipid, at least one nonionic surfactant and at least one silicone, and method of using same
The present invention is drawn to a composition and method for dyeing keratinous substrates containing: (a) at least one phospholipid; (b) at least one nonionic surfactant; (c) at least anionic silicone; (d) at least one dye chosen from oxidation dye precursors and direct dyes. The compositions of the present invention may optionally contain at least one thickening agent, at least one alkaline agent, at least one fatty substance other than a fatty acid, at least one salt, and at least one oxidizing agent.
US08529635B2 Electronic device security and tracking system and method
A system and method for securing and tracking an electronic device. The system includes hardware, software and firmware components that cooperate to allow tracking, disabling, and other interaction with the stolen electronic device. The system includes an application component, non-viewable component and Basic Input/Output Subsystem (BIOS) component that are present on the electronic device. The BIOS component maintains the secured environment of the application and non-viewable components. If only the application component was provided, a simple low level format of the hard disk drive would remove the application and bypass the security features. The system implements an “application and BIOS” based solution to electronic device security.
US08529634B2 Prosthetic limbs with means capable of reducing torque in the initial period of bend of knee joint
A technology for making the sensation at use of prosthetic limbs utilizing a hydraulic cylinder and a spring cylinder as comfortable as at use of those utilizing a pneumatic cylinder and further for improving walk following properties. In particular, the arrangement of a hydraulic cylinder or a spring cylinder, or the like, is specified. Accordingly, the resistance produced by the hydraulic cylinder or spring cylinder in accordance with an increase of knee angle is increased, The first torque T1 at the first stage of initial period of bend of the knee joint is made small, while the second torque T2 at the second stage of final period of the further advanced bend of knee joint is made large, thereby satisfying a relation of T1≧T2, as different from conventional ones.
US08529633B2 Cotyloid implant for a hip prosthesis
A cotyloid implant for a hip prosthesis, includes a first type of insert (2) with a spherical internal cavity (2a), for the mounting of a hemispherical core (4) with a capacity for mobility which has an internal cavity (4a) for co-operation with articulation with a femoral head, a second type of insert with an internal cavity for cooperation with a femoral head with articulation, characterized in that the center of rotation of the femoral head is different from the axis of rotation of the first type of insert (2) and/or of the second type of insert.
US08529632B2 Thumb metacarpal implant
A hemi-arthroplasty implant (11) joint replacement for the base of the first metacarpal of the CMC joint is created which can effectively restore and reestablish functional joint mechanics. The implant (11) has a unique head section (13) creating a particular interrelation between a spherical head articular surface (19), that is received in a surgically prepared cavity in the trapezium, wherein a supporting neck (21) in a re-entrant region joins the head to a flat, generally oblong collar (15).
US08529629B2 Shoulder prosthesis with humeral fracture stem
Various embodiments of the present invention are directed to a shoulder prosthesis. These embodiments may relate to a shoulder prosthesis including, for example, a humeral stem for fracture indication. Of note, certain embodiments of the present invention provide a humeral prosthesis with improved integration of the tuberosities around the humeral stem. Various methods relating to uses and applications of the prosthesis are also disclosed.
US08529628B2 Expanding intervertebral device and methods of use
Disclosed is a spinal stabilization device having a plurality of elongate arms having a distal end portion and a proximal end portion, wherein the elongate arms define an interior volume between the distal end portion and the proximal end portion; at least one limit band coupled circumferentially to one or more of the plurality of elongate arms; and a tensioning element positioned within the interior volume. The plurality of elongate arms can transition from a constrained, delivery configuration that is radially contracted and axially elongated to a relaxed, deployment configuration that is radially expanded and axially shortened.
US08529627B2 Intervertebral spacer
An intervertebral insert member and an instrument for positioning the insert in a space between vertebral bodies in vivo. The insert member is advanced by the instrument into a prepared site located between adjacent vertebral bodies. Upon reaching the appropriate insertion point the sleeve is retracted and a pivotal motion is imparted to the insert. The insert member is pivotally attached to the distal end of the delivery instrument such that it can be articulated about a pivot point that is located on the insert member until it is properly positioned. The positioning instrument is then released from the insert member and removed from the space between the vertebral bodies.
US08529622B2 Intraocular implants and related kits and methods
Devices, methods and kits are described for reducing intraocular pressure. The devices include a support that is implantable within Schlemm's canal and that may restore or maintain at least partial patency of the canal without substantially interfering with transmural or transluminal fluid flow across the canal. The devices utilize the natural drainage process of the eye and may be implanted with minimal trauma to the eye. Kits may include a support and an introducer for implanting the support within Schlemm's canal. Methods may include implanting a support within Schlemm's canal, where the support is capable of restoring or maintaining at least partial patency of the canal without substantial interference with transmural or transluminal fluid flow across the canal.
US08529621B2 Methods of repairing an abnormal mitral valve
The present invention refers to an annular prosthesis for mitral valve. In one of its embodiments the annular prosthesis for mitral valve is made up of a posterior half-ring and an anterior half-ring coupled to each other on a first transverse plane which defines a maximum width section of the prosthesis, characterized in that the ratio between the distance between said anterior half-ring and said posterior half-ring, as measured along a second plane, perpendicular to said first plane and equidistant to said couplings, and said maximum width of the prosthesis is lower than ¾.
US08529620B2 Inwardly-bowed tricuspid annuloplasty ring
A prosthetic tricuspid remodeling annuloplasty ring having two free ends and at least one inward bow to help reduce chordal tethering. The ring may have segments corresponding to the anterior, posterior and septal leaflets, with inward bows located adjacent one, two or all leaflets. Convex corners separate the concave inward bows, with inflection points therebetween. The ring has a semi-rigid inner body covered by fabric or a suture interface such as silicone and fabric.
US08529616B2 Implantable expandable medical devices having regions of differential mechanical properties and methods of making same
An implantable expandable medical device in which selected regions of the device are in a martensite phase and selected regions are in an austenite phase. The martensitic regions exhibit pseudoplastic behavior in vivo and may be deformed without recovery under in vivo body conditions. In contrast the austenitic regions exhibit superelastic behavior in vivo and will recover their pre-programmed configuration upon deformation or release of an applied strain.
US08529614B2 Vascular stenting and other procedures
Described herein are flexible implantable occluding devices that can, for example, navigate the tortuous vessels of the neurovasculature. The occluding devices can also conform to the shape of the tortuous vessels of the vasculature. In some embodiments, the occluding devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. Some embodiments describe methods and apparatus for adjusting, along a length of the device, the porosity of the occluding device. In some embodiments, the occluding devices allows adequate blood flow to be provided to adjacent structures such that those structures, whether they are branch vessels or oxygen-demanding tissues, are not deprived of the necessary blood flow.
US08529607B2 Sacral tether anchor and methods of use
A system for restricting flexion of a spinal segment in a patient comprises a constraint device having a tether structure and a compliance member coupled with the tether structure. The tether structure is adapted to be coupled with a superior spinous process and a sacrum. The system also includes an anchor member that is anchored to the sacrum. The anchor member has an attachment feature that is adapted to couple with the constraint device.
US08529604B2 Multi-axial bone screw assembly
A bottom-loading multi-axial bone anchor apparatus is disclosed. The apparatus includes a receiver member, a crown member, a bone anchor and a retaining member. The receiver member defines an upper opening and a lower opening, which may form part of the same opening, a channel, and a groove. The crown member and bone anchor are loaded into the lower opening of the receiver member, and the retaining member fits around the bone anchor and into the groove in the receiver member. The bone anchor is capable of multi-axial positioning with respect to the receiver member. An elongated member is placed in the channel of the receiver member, contacting the crown member, and a compression member is applied via the upper opening. The compression member presses down on the elongated member, which presses down on the crown member and locks the bone anchor between the crown member and the retaining member.
US08529596B2 Vascular and bodily duct treatment devices and methods
Devices including, but not limited to, a self-expandable member having a proximal end portion and a main body portion. The self-expandable member is movable from a first delivery position to a second placement position, in the first delivery position the expandable member being in an unexpanded position and having a nominal first diameter and in the second position the expandable member being in a radially expanded position and having a second nominal diameter greater than the first nominal diameter for deployment within a vessel or duct of a patient. The expandable member includes a plurality of cell structures with the cell structures in the main body portion extending circumferentially around a longitudinal axis of the expandable member and the cell structures in the proximal end portion extending less than circumferentially around the longitudinal axis of the expandable member to form first and second peripheral rails that vary in width along their lengths.
US08529595B2 Intravascular filter
An intravascular filter provides filtering capacity while retaining desired blood flow. An illustrative filter can include a first filter leg and a second filter leg, each of which have a free end and an opposite joined end. The joined end of each filter leg is secured to a center hub. A first portion of each filter leg extends in a first direction while a second portion of each filter leg extends in a second direction. An apex is positioned between the first and second portions of each filter leg.
US08529594B2 Nasal support device and method
The present disclosure provides a device and method for facilitating air flow in the nasal passage of a domestic animal. The nasal support device (NSD) disclosed herein is useful for facilitating air flow during rest, physical exertion, respiratory ailment, etc. The NSD secures to the nose of a domestic animal to support the unsupported lateral vestibular walls of the nasal passages by lifting or stenting.
US08529593B2 Medical instrument for cutting tissue
A medical instrument for cutting tissue having a tubular outer shaft which, in the area of its distal end, has at least one window with at least one blade, and further comprises a tubular inner shaft which is rotatable about a longitudinal axis, is received in the outer shaft and has, at its distal end, a cutting element which is arranged in the area of the at least one window of the outer shaft and is provided with several circumferentially arranged openings, each of the openings of the cutting element having at least one blade which, when the cutting element is moved in rotation, cooperates in a cutting action with the at least one blade of the outer shaft. It is proposed that at least some of the openings of the cutting element should have different widths, seen in a circumferential direction.
US08529591B2 Anastomotic instrument, endoscope system, and control method of anastomotic instrument
An anastomotic instrument includes first and second units. The first unit is attached to a distal end portion of an insert section of an endoscope, and has a self-propellable apparatus and an anvil. The second unit is attached behind the first unit, and has a cartridge and a balloon. The insert section with the anastomotic instrument is inserted into the alimentary canal. In the alimentary canal, fluid is sucked out from space enclosed by the first and second unit through a suction port provided in the cartridge, to bring the space into negative pressure. While the alimentary canal is shrunk in the space, the second unit is shifted relative to the first unit. In a state where the shrunk alimentary canal is caught between the first and second units, a cutter resects living body tissue, and staples are struck to join edges of an incision of the alimentary canal.
US08529586B2 Non-invasive surgical ligation clip system and method of using
A surgical ligation clip capable of remote deployment through a cannula to engage an anatomical structure.
US08529585B2 Surgical clamp and surgical clamp installation tool
A surgical clamp in certain embodiments may be configured to operate with a surgical installation tool. The clamp may have two elongated members with a bight portion that joins the two elongated members at a proximal end of the clamp and that may bias the two elongated members in an open position at a distal end. The bight portion may have one or more engagement features, such as a slotted aperture or other engagement or coupling feature. A clasp mechanism at the distal end of the clamp may have a male or first component disposed on or adjacent one of the two elongated members and a female or second component disposed on or adjacent the other of the two elongated members at the distal end of the clamp. The installation tool may include an elongated member with a proximal end and a distal end that has an engagement feature to engage the clamp, such as at the bight portion. A handle in one embodiment may be provided at the proximal end of the installation tool, while a head at the distal end may be configured to receive and/or engage the proximal end of the clamp and may also be operable to articulate in at least one plane.
US08529584B2 Median lobe band implant apparatus and method
A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes a delivery device configured to deploy and implant devices for compressing, distracting and/or retracting the lobes of a prostate.
US08529578B2 Instrument and associated method of trialing for modular hip stems
A trial (100) for use in performing joint arthroplasty is provided. The trial (100) fits to a cavity (103) in the canal (105) of a long bone (107) and assists in the performing of a trial reduction in performing joint arthroplasty. The trial (100) includes a stem portion (102) and a neck portion (104) fixedly connected to the stem portion (102) in a plurality of selectable positions with respect to the stem portion (102).
US08529575B2 Surgical clamp
A surgical clamp includes first and second supports respectively having first and second engagement sections. The first and second supports are pivotably connected at a connection by a pivotal portion such that the first and second supports are pivotable about a pivot axis extending through the connection. An opening is defined between the first and second engagement sections for receiving a bone of a patient. A connecting tube includes a first end fixed to the connection. A guiding tube includes an end connected to a second end of the connecting tube and is located in a central plane of the opening between the first and second engagement sections. The central plane includes the pivot axis and has equal spacing to the first and second engagement sections. A sliding rod is fixed to the connecting tube and includes a sliding groove slideably receiving a pole located on the pivotal portion.
US08529573B2 Distal femoral cutting guide
A device and a method for establishing a position and orientation for a preliminary saw cut in a distal end of a femur to prepare the femur for installation of a prosthetic knee joint. A guide block defining a cutting plane is carried on an adjustably positioned locating arm that is supported on an alignment body that can be mounted on a femur either with or without an intramedullary rod in place in the distal end of the femur. Adjustment screws and horizontal slots in the alignment body provide for varus/valgus angular adjustment of the position of the alignment body. An adjustment guide block may have a saw guiding face defining a differently oriented cutting plane.
US08529572B2 Head centering jig for femoral resurfacing
There is described a jig for identifying a point on the femoral head which is in alignment with a central axis of the femoral neck. The jig comprises a first member which defines a plane and has means for at least partially receiving the femoral neck. The jig also comprises a guide member which is mounted apart from the first member and which defines an axis at right angles to the plane defined by the first member. The axis of the guide member intersects the plane at a point which is a predetermined distance away from the means receiving the femoral neck. In addition, the jig comprises an elongate alignment means which is mounted with respect to the first member and which is spaced apart from, but extends parallel to, the axis of the guide member. There is also described a kit for use in the resurfacing of the femoral head. The kit comprises at least one jig as previously described.
US08529568B2 Surgical cutting tool
The present invention pertains generally to a surgical tool for cutting and shaping bone, cartilage and other anatomical structures. In particular, described herein are surgical tools having at least two cutting surfaces.
US08529567B2 Surgical device with smart bit recognition collet assembly to set a desired application mode
A surgical device of a drill/driver with bit recognition to set a desired application mode and a method of utilization thereof is provided. Various operating modes of the drill/driver are automatically set by a sensor which recognizes the bit applied to the drill/driver. A method of utilizing the drill/driver allows the drill driver to apply surgical screws at very high speeds while automatically preventing excessive torque levels that would strip out the surgical screw from the patient's bone.
US08529566B2 Vessel sealer and divider with knife lockout
An endoscopic forceps includes a housing having a shaft attached thereto that supports a pair of jaws disposed at a distal end thereof. A drive assembly having a drive shaft with a proximal end is operable to move the jaws relative to one another from an open to closed positions. A knife assembly is operable to advance a knife through tissue disposed between the jaws and includes a flange disposed thereon. A knife lockout is included that has a flange configured to engage the proximal end of the drive shaft and a lockout arm configured to engage the flange of the knife assembly to prevent movement thereof. Movement of the jaws to the closed position causes the proximal end of the drive shaft to engage the flange on the lockout which causes the lockout arm to disengage the flange on the knife assembly to permit advancement of the knife.
US08529564B2 Medical electrocautery instrument assistant device
A medical electrocautery instrument assistant device is disclosed including a pump tube, a hollow sleeve tube on an end of the pump tube, and a tube interface on another end of the pump tube and opposite to the hollow sleeve tube. At least a clip is provided between the hollow sleeve tube and the tube interface, each clip forming a position adjusting portion and a clipping portion. Different types of electrocautery instruments remain optimal pump positions relative to the pump tube, drawing out waste blood water and the electrocautery smoke almost entirely, and avoiding hiding operation cuts from view during operations.
US08529557B2 System and method for stray light compensation of corneal cuts
A system and method to compensate for the deformation of an eye requires calculation of an induced deformation angle Ψ, wherein the deformation is intentionally induced during laser surgery by a contact lens, and a refraction angle φ. Specifically, during laser surgery, the cornea of an eye is typically stabilized by a contact lens. This deforms the cornea. When the contact lens is removed after the surgery, the cornea recovers from the deformation. For the present invention, the angle Ψ is calculated, and corrected by the angle φ, so that surfaces altered during surgery (e.g. by LIOB) will become substantially parallel to incoming light in the eye, after the contact lens has been removed after surgery.
US08529552B2 Apparatus, system and method for administration of a substance
The present disclosure relates to an infusion control valve adapted to be actuated by a valve actuator. The present disclosure further relates to an infusion valve actuator adapted to actuate an infusion control valve upon being triggered by an authentication unit. Furthermore, the present disclosure relates to methods for the administration of a substance.
US08529551B2 Acoustically controlled substance delivery device
Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, an acoustic control signal may be used.
US08529547B2 Method of collecting specimen and method of diagnosing subject to detect upper digestive system disease
A method of collecting a specimen of the present invention detects upper digestive system disease. The method of collecting a specimen includes: a step of administering a stimulant of pancreatic juice secretion or a stimulant of bile secretion to a subject; a step of positioning sampling equipment in the duodenum of the subject into which duodenal juice is secreted, the sampling equipment being used to collect and store the duodenal juice; a step of starting collection of the duodenal juice by the sampling equipment within five minutes from the administration of the stimulant of pancreatic juice secretion or the stimulant of bile secretion; and a step of stopping collection of the duodenal juice such that collection time for the duodenal juice is within five minutes from the start of collection.
US08529546B2 Sinusal guide cannula and kit for irrigation, suction and washing
The present invention provides a cannula guide tube; and a kit with the cannula guide tube, a flexible transparent cannula or a transparent catheter with an inflatable balloon at the catheter end, and an exploratory device. The kit is for irrigation, suction and washing out purulent or liquid discharges from bacteria infected sinuses. First, the exploratory device is used to find the entrance orifice to a sinus; second, the cannula guide tube is positioned in the sinus orifice entrance; and third, the flexible transparent cannula or the transparent catheter is inserted through the cannula guide tube into the sinus. The flexible transparent cannula or transparent catheter is used to suction the purulent or liquid discharge and to irrigate and wash out the sinus. The cannula guide tube has an opening before the tube end, wherein the opening allows seeing the flexible transparent cannula or transparent catheter inside the tube and the flow of purulent or liquid discharge suctioned from the sinus, as the purulent discharge flows throughout the flexible transparent cannula or the transparent catheter.
US08529544B2 Catheter system with attachable catheter hub
A hemodialysis catheter assembly adapted for use in a subcutaneous tunneling procedure incorporates a mechanism for securing the catheter hub member to the elongated catheter, and to provide the requisite fluid communication between fluid passages within the hub and the catheter lumens within the catheter. The catheter hub member may be connected to the elongated catheter after implantation of the catheter via a subcutaneous tunneling procedure.
US08529539B2 Medical devices employing electroactive polymers for delivery of particulate therapeutic agents
In accordance with one aspect, medical devices are provided which comprise an electroactive polymer material and therapeutic-agent containing particles. The device is configured such that the particles are delivered from the device upon actuation of the electroactive polymer material.
US08529538B2 Drug-delivery pumps and methods of manufacture
Embodiments of an implantable electrolytic pump include a first expandable diaphragm and a second flexible diaphragm, and first and second chambers each for containing a fluid, wherein the first expandable diaphragm separates the first and second chambers and provides a fluid barrier therebetween, and the second chamber is formed between the first expandable diaphragm and the second flexible diaphragms. The pump may further include electrolysis electrodes within the first chamber for causing generation of a gas therein and to thereby expand the expandable diaphragm so that fluid is forced from the second chamber into a cannula.
US08529537B2 Absorbent article with enclosures
An absorbent article comprises a bodyside liner, an outer cover, an absorbent body located between the bodyside liner and the outer cover, and an enclosure. The enclosure comprises a cover and backing joined together to form a pocket with an object disposed therein. The enclosure is joined with the absorbent article and is adapted to transition from a closed condition to an open condition such that the object disposed within the enclosure may be accessed.
US08529536B2 Elastic composite having cross-directional elasticity and a system and method for making the elastic composite
A method of making an elastic composite entails conveying a first sheet on a conveyor, and wrapping a section of elastic about the first sheet and the conveyor, thereby applying elastics cross directionally across the sheet. A second sheet is then applied onto the first sheet thereby creating a subcomposite including the two sheets and elastics sandwiched therebetween, wherein two elastics extend outward from one side of the subcomposite, about the conveyor, and return into an opposite side of the subcomposite. The subcomposite is cut through the first and second sheets and the elastics, thereby separating the subcomposite into a first carrier and a second carrier, each carrier including a material layer, whereby spaced apart elastics extend from the first carrier to the second carrier, the first and second carriers defining an exposed elastic region therebetween formed by the elastics.
US08529531B2 Medical tissue extraction instrument
Disclosed is a medical tissue extraction instrument, which can allow an inspector to accurately locate a fine needle at a desired tissue extraction position without any need for assistance while assuring stable tissue extraction. The medical tissue extraction instrument includes a tissue extraction controller to control the pressure of a suction tube connected to a fine needle during extraction of tissue. The tissue extraction controller includes a suction pressure generator taking the form of a footboard and adapted to control a suction operation of the suction tube by being pushed downward.
US08529529B1 Placental blood extractor
A placental blood extractor consists of an outside box having plurality of plastic bags for compressing the placenta and mounted to the top of the box. The lower part of the box has possibility to use several different circularly movable plates for mechanically facilitating the flow of the blood in the collecting veins on the fetal side of the placentas toward the central main umbilical cord vein. The box has an opening in the central lower part of the box and the lower area mechanical tray for the umbilical cord to exit the box. Blood is collected from umbilical cord and is to be collected into commercial collection bags. The area of the bag for collection of blood may be under negative pressure to facilitate the collection of blood but also gravity force may be used for that purpose. Both, the first part with the compression chambers as well as the second part, the Collector of Blood have pumps and manometers controlled by computer in their operations.
US08529524B2 Anti-drawback medical valve
A gland member within a medical valve is configured to have a substantially consistent or enlarging internal volume as the valve transitions from a closed mode to an open mode. The valve has a housing forming an interior containing a flow path, and a stationary post member within the interior. The post member has a lumen that is a part of the flow path. The lumen has an opening to the interior of the housing. The valve further includes a gland member circumscribing the post member to produce a variable volume region formed at least in part between the gland member itself and the post member. The variable volume region is a part of the flow path, while the gland member occludes the post lumen opening when in the closed mode. The variable volume region has an open volume that is no less than its closed volume.
US08529522B2 Fluid transfer device having removable needle cartridge
A fluid transfer device including a cartridge having a plurality of needles, an advancer operative to selectably advance any of the plurality of needles in the cartridge to a needle deployment position, and a syringe operative to convey fluid through the needle in the needle deployment position.
US08529519B2 Tight-sealing cap for liquid drug-expelling part
Provided is a tight-sealing cap for the liquid drug-expelling part of a syringe that not only minimizes the space that creates reduced pressure, which is a cause of leakage, but is also easy to remove because it is easily twisted off, easily deformable and easily admits air for releasing the vacuum when removed, and that can prevent leaking of a liquid drug from a luer nozzle. The cap is made of an elastic material, and the following means are used in the cap, which is configured from a thick upper surface part, an outer tubular part that is formed below the periphery thereof, and an inner tubular part that is formed inside the same. First, the inner tubular part is formed so that the tip of the luer nozzle can be inserted tightly into the same, and the luer nozzle can be tightly sealed at the site of contact thereof. Second, the outer tubular part is formed so that it contacts the luer lock closely therein and can seal the luer lock tightly at the site of contact thereof. Third, the length of the site of contact between the outer tubular part and the luer lock is shorter than the length of the site of contact between the inner tubular part and the luer nozzle.
US08529515B2 IV-catheter insertion device
The present disclosure is directed to an IV-catheter insertion device, which comprises a catheter hub at the proximal end of a tubular catheter, a protective barrel releasably joined to the catheter hub in a ready position, a needle hub with an attached hollow needle, the hollow needle extending through the catheter hub and the tubular catheter in the ready position such that that needle tip projects distally of the distal end of the tubular catheter, wherein the needle hub is displaceable in the protective barrel, and a spring clip as a needle guard element whose proximal rear wall is fixed at a distal end area of the protective barrel by means of holding members, wherein the protective barrel and the catheter hub are held by the spring clip in the ready position, and the spring clip is released from the catheter hub in a protected position in which the spring clip covers the needle tip.
US08529513B2 Device for metered administration of a liquid product
A device for administering an injectable substance, the device including a housing, a translation member moveable in a translation direction, a rotation member rotatably moveable about a rotation axis and coupled to the translation member to support the translation member counter to the translation direction, a rotary bearing including a bearing body bearing the rotation member rotatably about the rotation axis, the rotary bearing having support surfaces for supporting the rotation member axially on the bearing body, and a device for reducing play whereby at least two support surfaces are brought into contact with a pressing force, thereby reducing an axial play of the rotary bearing.
US08529512B2 Cylinder pump
The present invention relates to a simple and small cylinder pump, which can stably supply a medical fluid regardless of the installed height of a liquid container or a blood bag. The cylinder pump includes an upper casing, and a lower casing coupled to the upper casing. An upper rotation member is rotatably inserted in the upper casing. A lower rotation member slidingly contacting the upper rotation member is rotatably inserted in the lower casing. An inner wall of the upper casing, a lower outer surface of the upper rotation member, an inner wall of the lower casing, and an upper outer surface of the rotation member constitute a cylinder having a single-tube shape. Plungers are installed on the upper rotation member and on the lower rotation member, respectively, and rotate in the cylinder, the ends of which are closed.
US08529509B2 Syringe drive device and medication dispensing apparatus
A syringe drive device 1 includes: a syringe holding section 3; a piston manipulating section 4; and a display section 6. An outer tube 202 of a syringe 201 is detachably held by the syringe holding section 3. A piston 203 of the syringe 201 is detachably engaged with the piston manipulating section 4. The piston manipulating section 4 moves in a direction in response to an operation of operation buttons 8A and 8B, and the piston 203 is thereby moved in a direction where the piston is pushed into or pulled out from the outer tube 202. An internal pressure of a medicinal solution container punctured with an injection needle 204 attached to the outer tube 202 of the syringe 201 is measured and displayed on the display section 6.
US08529507B2 Cannula protector and single-use syringe system
The invention relates to a cannula protector that serves to cover a cannula which has been attached to a syringe, particularly for the purpose of preventing unintended damage to the cannula as well as contamination of the cannula shortly before its use on the patient. The invention also relates to a single-use syringe system with such a cannula protector.A cannula protector according to these principles includes a tubular sleeve and a bellows which, in part together with the sleeve, completely encloses at least the area of the cannula. The cannula protector usually also comprises a radially acting clamp or engagement spring, whose function is to hold the inserted single-use syringe in the desired position, or to activate the protective mechanism.
US08529505B2 Deflectable catheter with bonded center strut and method of manufacture for same
A catheter for diagnosing or treating the vessels found within a body or body space includes a center strut that is bonded, preferably thermally, along its longitudinal axis with the thermoplastic tubular member within which it is housed. The tubular member preferably has three layers: an inner layer, a braided layer and an outer layer. The composite catheter is made using a process in which two half-cylinder shaped mandrels are placed on each side of the center strut while the strut is heated in order to cause the thermal bonding. The bonded center strut provides in-plane deflection and improved transfer of torque to the tip of the catheter.
US08529501B2 One time use breastpump assembly
A breastpump assembly is disclosed. The breastpump assembly includes a breast shield within which a woman's breast is received, a conduit structure communicating with the breast shield, a container for collecting milk, and a valve mechanism closing the breastpump assembly from ambient air when initially provided to a user, the valve mechanism being opened to allow ambient air to pass into the breastpump assembly through removal of the container, so as to substantially disable the breastpump.
US08529496B2 Peritoneal dialysis machine touch screen user interface
A peritoneal dialysis machine including a membrane pump and a touch screen display that includes a mode-indicating portion and an operation-descriptive portion, the mode-indicating portion having a plurality of touch sensitive indicia each indicating one of a plurality of modes in which the machine can operate, the display being used to keep a patient continually informed of which one mode of at least three operating modes the machine is operating in, as the operation-descriptive portion changes to display details of a specific operation being carried out within the one mode, the indicia for each of the three operating modes always being visible to the patient while the machine is operating, the operating mode being selected by the patient touching one of the indicia on the screen.
US08529495B1 Middle ear ventilation tube
The middle ear ventilation tube is a ventilation tube for placement through an opening formed through the tympanic membrane to drain fluid from the middle ear to the ear canal or outer ear. The middle ear ventilation tube includes a hollow, substantially cylindrical tube having axially opposed first and second open ends. A first annular flange is formed about the first open end of the tube. The first annular flange defines a tapered angled edge for insertion through an opening formed through the patient's tympanic membrane. A second annular flange is formed about the second open end of the tube. The second annular flange has a tongue portion extending outwardly therefrom for grasping and manipulation. A notch is formed in the tongue portion, and a pair of recesses are formed in the second annular flange, each for engaging a needle for fine adjustment within the ear.
US08529487B2 Method and apparatus for priming an extracorporeal blood circuit
A method and apparatus for priming an extracorporeal blood circuit, in which the patient end of an arterial line (79) is connected to a first discharge port (61), and the patient end of a venous line (87) is connected to a second discharge port (62). The two discharge ports are connected to a used dialysate line which connects a dialyser (33) to a drain. The arterial and venous lines are filled with a priming fluid, while the air contained in the arterial and venous lines is evacuated partly through the first discharge port and partly through the second discharge port. Two check valves (65, 66) prevent flow from the used dialysate line towards the two discharge ports. The invention reduces the risk of errors on the part of an operator readying the priming configuration, as well as the risk of contamination of the extracorporeal circuit during the priming phase.
US08529483B2 Short stretch therapeutic compression device for the extremity and method
A compression device to be wrapped around the distal extremity of a patient for use in moderate to severe swelling/lymphedema. The device includes a flexible planar compression material of preferably short-stretch compression material. Fasteners are attached to the first and second band portions. The compression material in preferred embodiment contains short-stretch compression material with 20%-60% stretch. The device is designed such that it may be used to augment compression to the hand when used in conjunction with compression to the fingers and arm. The device is designed to be applied easier with one hand.
US08529482B2 Orthopedic tutor for spine and method
The tutor of this invention is made up of a support (1) to be fixed to the chest of the user with a chin rest (2) being connected to the support (1) through a hinge (7) and also being anchored at an element (3) provided on the patient's neck, and of a plate (4) positioned on the convexity of the patient's dorsal curve and having applied thereto a posteroanterior thrust. The said chin rest (2) is engaged to a means (8) articulated to the support element (1) in a central position with respect to the chin rest (2) and is able to generate and adjust an anteroposterior upwardly oblique thrust F on the chin of the user. The method for using the said tutor implies putting on and fitting the chin rest, then manually activating the means (8) engaged on the chin rest (1) so as to obtain, on the chin of the user, who keeps his/her mouth shut and head reclined forward, a desired anteroposterior upwardly oblique thrust F which, via the user's yaw, transmits to the atlas bone (first vertebra of rachis) an equal force R whose horizontal component Ro is cause for a retropositioning of the cervical curve, and whose vertical component Rw is cause for an upwardly directed stretching and, consequently, a direct straightening of the underlying dorsal curve.
US08529480B2 System and method for treating cervical vertebrae
Systems, methods and computer readable mediums encoded with computer instructions for treating cervical vertebrae are provided. Certain cervical vertebrae treatment devices include a head support configured to support a patient's head, and a motion component operably connected to the head support, wherein the motion component is configured to provide movement of the head support about at least three axes. Certain devices also include a control system operably connected to the motion component and configured to control operation of the motion component.
US08529476B2 Catheter with strain gauge sensor
A medical probe, including a flexible insertion tube, having a distal end for insertion into a body cavity of a patient and which is configured to be brought into contact with tissue in the body cavity. The probe further includes a sensor tube of an elastic material, contained inside the distal end of the insertion tube and configured to deform in response to forces exerted by the tissue on the distal end. The probe also includes a plurality of strain gauges fixedly attached to a surface of the sensor tube at different, respective locations and configured to generate respective signals in response to deformations of the sensor tube.
US08529474B2 Strain monitoring system and apparatus
A system for monitoring strain as an indicator of biological conditions, such as spinal fusion, glucose levels, spinal loading, and heart rate. The system includes an inter-digitated capacitor sensor, and RF transmitter, and an associated antenna, all of which are microminiature or microscopic in size and can be implanted in a biological host such as a human or animal. An inductively coupled power supply is also employed to avoid the need for implantation of chemical batteries. Power is provided to the sensor and transmitter, and data is transmitted from the sensor, when an external receiving device, such as a handheld RF ID type receiver, is placed proximate the location of the implanted sensor, transmitter and inductively coupled power supply. The implanted sensor, transmitter and inductively coupled power supply can be left in place permanently or removed when desired.
US08529472B2 Blood analysis device and blood analysis system using the same
A blood analysis device wherein a carrying part blood attached thereto can be localized to thereby facilitate handling after using. When incorporating blood collected from the punctured skin, the blood is held in a skin-puncturing device or the like so that an uncontaminated holding area can be enlarged and the degree of freedom in handling can be increased. A blood analysis device which comprises a plate type device body having a blood collection port for incorporating blood and a ventilation hole formed at a certain distance apart in a face and a passage located inside for connecting the blood collection port to the ventilation hole, and a blood analysis section located within the passage for analyzing the blood having been incorporated via the blood collection port.
US08529467B2 Tissue excision device with a collapsible stylet
A biopsy device includes a coring cannula, a retract stylet, and a localization needle. The coring cannula has a longitudinal axis and a shaft centered on the axis. The stylet has a tip containing at least one blade and a central passage. The localization needle has a channel and is slidably disposed within the central passage. A drive mechanism rotates the cannula and moves the cannula in a direction parallel to the longitudinal axis of the cannula. A guide element has a first end and a second end and is slidably disposed within the channel of the localization needle. The guide element is movable from a first position to a second position within the localization needle.
US08529466B2 Tissue excision device with rotating stylet blades
A biopsy device includes a coring cannula, a retract stylet, and a localization needle. The coring cannula has a longitudinal axis and a shaft centered on the axis. The stylet has a tip containing at least one blade and a central passage. The localization needle has a channel and is slidably disposed within the central passage. A drive mechanism rotates the cannula and moves the cannula in a direction parallel to the longitudinal axis of the cannula. A guide element has a first end and a second end and is slidably disposed within the channel of the localization needle. The guide element is movable from a first position to a second position within the localization needle.
US08529465B2 Biopsy marker delivery devices and methods
A biopsy system includes a biopsy device operable for taking one or more biopsy samples from a patient and a marker delivery device. The biopsy device includes a body portion having an alignment feature and a hollow biopsy needle extending distally from the body portion. The marker delivery device includes a marker deployer tube and an alignment feature associated with the marker deployer tube. The alignment feature on the marker delivery device is configured to matingly engage with the alignment feature on the biopsy device. A marker delivery device includes a resilient marker guide ramp.
US08529464B2 Computer-assisted diagnostic hearing test
Method and System are disclosed for a computer-assisted diagnostic hearing test. The computer-assisted diagnostic hearing test includes an ambient noise monitoring module configured to monitor an ambient noise in a surrounding environment, a patient information module configured to receive patient information and hearing related tests selections, and a pure tone threshold module configured to facilitate manual testing of a pure tone threshold test. The computer-assisted diagnostic hearing test further includes a speech reception threshold module configured to facilitate manual testing of a speech reception threshold test, and a speech discrimination module configured to facilitate manual testing of a speech discrimination test.
US08529463B2 Systems and methods for testing vestibular and oculomotor function
The invention relates to systems and methods for testing vestibular and oculomotor function. One aspect of the invention provides a vestibular and oculomotor function testing device including a track supported by a plurality of bearings, an engine configured to selectively displace the track, and a head coupling component coupled to the track. The head coupling component is configured to convey a movement generated by the engine to a subject's head in one or more axes.
US08529458B2 Method and apparatus for assessment of fluid responsiveness
Methods and apparatus for determining a cardiac parameter from cardiovascular pressure signals including arterial blood pressure (ABP) and the photoplethysmographic signal to quantify the degree of amplitude modulation due to respiration and predict fluid responsiveness are disclosed. Disclosed embodiments include a method for assessing fluid responsiveness implemented in a digital computer with one or more processors comprising: (a) measuring a cardiovascular signal, and (b) computing a dynamic index predictive of fluid responsiveness from said cardiovascular signal using a nonlinear state space estimator. According to one particular embodiment, and without limitation, the nonlinear state space estimator is based on a model for cardiovascular signals such as arterial blood pressure or plethysmogram signals, and employs a marginalized particle filter to estimate a dynamic index predictive of fluid responsiveness that is substantially equivalent to a variation in pulse pressure of said cardiovascular signal.
US08529455B2 Systems and methods for estimating the size and position of a medical device to be applied within a patient
The field of the invention relates to medical imaging systems, and more particularly to systems and methods for estimating the size and position of a stent or other medical device within a patient. In one embodiment, a medical imaging system includes an elongated tubular member having distal and proximal ends, configured to be inserted into a vessel of a patient, an imaging device coupled to the distal end of the elongated tubular member, and a console electrically coupled to the imaging device, wherein the console includes a computer-usable medium, electrically coupled to the imaging device, having a sequence of instructions which, when executed by a processor, causes said processor to execute a process including generating an image of the vessel, and overlay one or more shapes onto the image age to provide a visual approximation of the size and position of a medical device to be applied within the patient.
US08529451B2 Shock wave coupling adapter and method of use
A shock wave adapter for use with a focused shock wave applicator has a flexible, rigid or semi-rigid membrane or housing adapted to be filled with a fluid. The membrane or housing is devoid of any air or gases and when filled forms a spacer volume for passing acoustic shock waves at low impedance. The wave pattern of the shock wave applicator enters the membrane or housing as a converging wave form to a focus inside the membrane or housing and exits through the membrane or housing in a diverging wave form into the patient to be treated. The spacer adapter may further include a gas filled shield around the perimeter of the fluid filled membrane or housing to block transmissions of acoustic shock waves.
US08529447B2 Creating a personalized stress profile using renal doppler sonography
In particular embodiments, a method includes accessing data streams from a renal Doppler sonograph and one or more of a heart-rate monitor, a blood-pressure monitor, a pulse oximeter, or a mood sensor monitoring a person, and generating a stress model of the person based on the data streams.
US08529445B2 Spreading retractor
A spreadable retractor for use in joint arthroplasty. The retractor includes a first arm having a first portion and a second portion that is movably coupled to the first portion. The second portion is also coupled to a first retaining member that is sized and shaped to retain a portion of a coracoid process. A second arm is also included in the retractor and is movably coupled to the first arm. The second arm has a first portion and a second portion that is movably coupled to the first portion. Also, the second portion is coupled to a second retaining member that is sized and shaped to couple to a resected humerus.
US08529444B2 Flexible surgical retractor
A surgical retractor including a slab-shaped member having a first edge and a second opposing edge, wherein a deformable elongate member is provided affixed to said first edge, said elongate member comprising an external wall defining an internal chamber, wherein the external wall is configured to be compressible and moldable to a surface, in particular, a human tissue surface within a surgical incision. A curved flexural handle may be provided attached to the second edge.
US08529436B2 Endoscope, endoscope system having the same and endoscope control method
An endoscope, an endoscope system having an endoscope, and an endoscope control method are disclosed. The endoscope includes: a main body and a buoyancy control device. The main body may be configured in the form of a capsule and include an image capturing unit for capturing image information. The buoyancy control device may control buoyancy by changing the volume of the main body. Images of various types of internal organs can be precisely captured.
US08529428B2 Methods of controlling magnetic nanoparticles to improve vascular flow
Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.
US08529423B2 Sheet folding and image formation apparatus
In a sheet folding apparatus, to enable a jammed sheet to be removed with ease when a jam occurs, a casing having a carry-in entrance and a carrying-out exit is divided into an upper unit and a lower unit via a first transport path for carrying a sheet from the carry-in entrance to the carrying-out exit, a second transport path for performing folding processing on a sheet is disposed in the direction for crossing the first transport path, and in the upper unit are disposed a sheet front end switchback path for reversing and carrying the sheet toward a folding roller pair and sheet deflecting means for guiding the sheet to the folding roller pair. Then, the upper unit is coupled to the lower unit to be openable and closable by a hinge shaft rotating around one side end portion orthogonal to the sheet transport direction of the first transport path.
US08529421B2 Package flap folding method and apparatus
An apparatus for folding the flaps of a package is provided. The apparatus has a pair of folding conveyors positioned such that, as a package having open major flaps is urged towards the folding conveyors, the folding conveyors fold the major flaps of the case to a closed position. The apparatus has a front flap mechanism configured to close the front flap of the package, and a rear flap mechanism configured to close the rear flap of the package.
US08529418B2 Balance therapy system
A balance board including a standing platform connected to a pivot ball. The standing platform provides an area for a subject to stand and can be moved by a set of deflector actuators. The deflector actuators can move the platform in both the lateral and vertical directions. A braking assembly is connected to the ball and the braking assembly increases or decreases rotation resistance to the ball. When resistance is increased to the ball, resistance to rotation for the platform is increased.
US08529417B1 Pushup exercise device
The pushup exercise device first is rugged and sturdy, for even the heaviest user. The vertical columns and bases may be square for best rigidity. The cross supports may be rectangular for the same reason. Finger holes are optionally provided for best grip, but a user can also place hands atop the upper blocks as chosen. Importantly, the device allows a user to elevate upper body off of the floor for less back and other body part strain, and to slightly decrease the resistance provided in a floor performed pushup. The device is highly portable.
US08529416B2 Exercising device
An exercising device includes a disc shaped member capable of rotating about a point of rotation. The exercising device also includes an elongated supporting member connected to the point of rotation of the disc shaped member. Further, the exercising device includes a braking mechanism carried by the elongated supporting member. The braking mechanism is capable of contacting the disc shaped member to apply a resistance to the rotation of the disc shaped member. Moreover, the exercising device includes a foot engaging member connected to the disc shaped member. The foot engaging member is adapted to be operated by feet of an individual. The operation of the foot engaging member by the individual against the resistance to the rotation applied by the braking mechanism exercises the individual.
US08529415B2 Dumbbell
A dumbbell with a selectable number of weight disks includes a handle with projectable pins in opposing directions, with end surfaces, a base assembly for accommodating two sets of weight disks standing upright, the weight disks having central openings. The projection lengths of the pins are stepwise selectable by an indexing device in order thereby to permit selection of the number of weight disks supported on the handle. Neighboring weight disks and the handle have mutually engaging connecting arrangements which axially interconnect the weight disks and the handle but which permit radial separation. In order to prevent the set projection lengths of the pins from being unintentionally altered, when a dumbbell lifted up out of the base assembly is used, the handle has a locking arrangement which locks the pins in the set projection positions.
US08529414B2 Neck exercise machine
A neck exercise machine includes a position plate fixed to a cam for rotation therewith about an axis of rotation. The position plate has a multiple of apertures which defines a multiple of start positions for the arm.
US08529404B2 Hydraulic control device
A hydraulic control device is provided with a linear solenoid valve, a shift valve, and a controller. The linear solenoid valve has a gain switching chamber which produces a biasing force in a direction to close the linear solenoid valve to switch the gain characteristic of the linear solenoid valve when oil pressure is supplied to the gain switching chamber. The shift valve is configured to be switchable between a supply state in which the output oil pressure from the linear solenoid valve is supplied to the gain switching chamber and a blocked state in which the supply of the output oil pressure is blocked. The controller brings the shift valve into the supply state when a necessary oil pressure of an engagement element is high and into the blocked state when the necessary oil pressure of the engagement element is low.
US08529403B2 Method for starting an engine
A method for improving starting of an engine that may be repeatedly stopped and started is presented. In one embodiment, the method adjusts a transmission actuator in response to engine combustion during an engine start. The method may improve vehicle launch for stop/start vehicles.
US08529396B1 Multi-speed automatic transmission
An automatic transmission includes a first planetary gear set including a first sun gear, a first pinion, a second pinion, and a common ring gear, and includes a second planetary gear set including a second sun gear, the second pinion, and the common ring gear. The transmission includes a third planetary gear set including a third sun gear, a third pinion, and a ring gear of the third set, and includes a fourth planetary gear set including a fourth sun gear, a fourth pinion, and a ring gear of the fourth set. The transmission also includes a first planetary carrier rotatably supporting the first pinion, the second pinion, and the third pinion. The common ring gear is directly connected to the ring gear of the fourth set, and a second planetary carrier rotatably supports the fourth pinion and is directly connected to the ring gear of the third set.
US08529395B2 Multi-speed transmission
A transmission is provided having an input member, an output member, four planetary gear sets, a plurality of coupling members and six torque transmitting devices. Each of the planetary gear sets includes first, second and third members. The torque transmitting devices may include clutches and brakes.
US08529390B2 Internal rocker arm type epicycle wheel system with bidirectional input and unidirectional output
The present invention is provided with the inner rocker arm type epicycle wheel system and combined with a one-way transmission to construct the inner rocker arm type epicycle wheel system capable of changing the driven direction of the input shaft while the output rotary direction of a cylindrical output shaft keeps constant, and characterized in that: through the inner rocker arm type epicycle wheel system being combined with the one-way transmission, the inner rocker arm type epicycle wheel system is equipped with a transmission operational function of bidirectional input and unidirectional output, thereby the inner rocker arm type epicycle wheel system with bidirectional input and unidirectional output of the present invention enables the transmission relation between the input shafts driven in two different rotary directions status and the one-way rotation cylindrical output shaft to have the same or different transmission speed ratios, when the input shafts are driven in the first rotary direction and in the second rotary direction.
US08529386B2 Ball
The present invention relates to an inflatable ball, in particular a soccer ball, having an outer shell comprising a plurality of panels, wherein the panels are interconnected by seams and each panel comprises at least one pseudo-seam extending over at least a part of the outer surface of the panel.
US08529385B1 Arrowhead having expanding blades controlled by gear mechanism
Disclosed is an arrowhead in which a plurality of expandable blades can be quickly and reliably retracted or expanded without using an additional means to bundle the expanding blades, thereby enhancing the penetrating capability or killing capability of an arrow. Particularly, a portion of a shaft forming the arrowhead is provided with a rack gear portion formed thereon and a lower end of each of the expanding blades is provided with a pinion gear portion, such that the rack gear portion and the pinion gear portion engage with each other and such a rack-pinion action controls the operation of retracting or expanding the expanding blades.
US08529379B1 Golf ball and tee setting and retrieving device
A grabbing system uses a typical first grabber located on a main shaft to grasp golf tees for setting into and retrieving them from the ground. A secondary shaft slidably passes through the main shaft of the device and has a second grabber such that the first grabber and the second grabber are simultaneously controlled by a single trigger mechanism. This allows a tee and ball to be grasped and released together such that setting the position of the secondary shaft with respect to the main shaft allows for precise penetration placement of the tee into the ground. A clipping system allow for easy carrying of the device, while optional support legs allow the device to free stand upright on the ground.
US08529378B2 Golf ball with a translucent layer comprising composite material
A golf ball comprising an opaque core, a composite cover layer, an intermediate layer, and an outer cover layer is provided. The composite cover layer and outer cover layer are formed from a translucent polymeric matrix, and a fibrous material is embedded in the translucent polymeric matrix of the composite cover layer. In one version, the fibrous material comprises a woven or non-woven mat. In another version, the fibrous material comprises a shape memory alloy. In yet another version, the fibrous material comprises a ferromagnetic material and the metal material is subjected to induction heating to improve adhesion between adjacent ball layers.
US08529377B2 Golf ball incorporating thermoplastic polyurethane
A rebound resilient golf ball having an core layer or layers with one or more cores, a scuff resistant cover of thermoplastic polyurethane surrounding the core layer or layers, and optionally a mantle layer positioned between the cover and the core layer or layers. The cover is made from a dendritic thermoplastic polyurethane that includes an isocyanate monomer and a hyper branched polyol, optional additional polyols, and one or more chain extenders. An optional mantle layer may also be made of thermoplastic polyurethane, particularly a dendritic thermoplastic polyurethane.
US08529374B2 Golf ball with negative hardness gardient core
A golf ball comprising a single layer core and a cover layer disposed about the single layer core, the single layer core being formed from a substantially homogenous formulation and comprising a geometric center and an outer surface, the single layer core further comprising an inner core region disposed about the geometric center, an outer core region adjacent the outer surface, and an intermediate core region disposed between the inner and outer core regions and extending radially from about 8 mm to about 18 mm from the geometric center. The single layer core has first, second and third hardnesses disposed within the inner core region, outer core region, intermediate core region, respectively, wherein the third hardness is greater than the first hardness and the second hardness, and a hardness of the outer surface is substantially the same as or lower than a hardness of the geometric center.
US08529371B2 Golf ball
The present invention provides a golf ball having a resilient core made of rubber, a cover of one or more layer encasing the core, and at least one intermediate layer disposed between the core and the cover, wherein the cover is made primarily of polyurethane, the intermediate layer is made primarily of ionomer, and the core has a surface hardness which is higher than the material hardnesses of the cover and the intermediate layer. The golf ball is able to limit the distance of travel more than official balls currently in use and, in spite of being a limited-distance golf ball, imparts a relatively soft and good ball feel on impact, in addition to which it has an excellent scuff resistance and, by minimizing the extent of decrease in the distance traveled by the ball when hit with an iron, minimizes the effect on golf play by amateur golfers.
US08529370B1 Golf club head with a compression-molded, thin-walled aft-body
A golf club head composed of a face component and an aft body composed of a long fiber material. The aft body is composed of a compression molded material. The compression molded aft-body is composed of two pieces which are bonded to a metal face component.
US08529367B2 Variable length golf club shaft
A variable length shaft assembly comprising at least one upper shaft portion, a lower shaft portion and a threaded fastener, wherein the threaded fastener removably connects the upper shaft portion to the lower shaft portion, is disclosed herein. The variable length shaft assembly may further comprise at least two upper shaft portions having different lengths so a golfer can adjust the total length of the shaft by removing one upper shaft portion and replacing it with another upper shaft portion having a different length. Methods of adjusting the length of a golf club shaft without damaging any portion of the shaft and variable length shaft kits are also disclosed herein.
US08529366B2 Putting aid
A putting aid which includes a base plate, guide rails attached to the base plate, which are spaced apart to form a guide passage for a putting stroke, and markers which are engaged with guide rails, each marker being engageable with the ground at a defined position, wherein the base plate and the guide rails are movable leaving the markers at the defined positions.
US08529365B1 Indoor golf swing practice implement
An indoor golf swing practice implement is provided with a total length from 16 to 20 inches and including a shaft with a standard golf grip on one end and with a weight at the other end. The total weight and balance of the practice implement is such that the implement moment is substantially the same as that of a regular golf club to provide the same feel, heft and swinging weight for practice of golf strokes in confined spaces.
US08529362B1 Elevated hand-held merry-go-round
An elevated hand held merry go round provides a hand hold elevated a distance above a playing surface to which a user may grab and rotate through an unobstructed zone between the hand hold and the playing surface. In the preferred embodiment the hand hold may be tilted at an angle relative to the playing surface so the user may pump themselves to maintain the round momentum in a manner somewhat similar to an individual pumping themselves on a swing to maintain themselves swinging. Alternative embodiments lack the tilt may be made in various dimensions to accommodate various numbers of users and may have more than one set of locations for hand holds.
US08529361B2 Drive shaft, in particular radial shaft for a gas-turbine engine
A drive shaft, in particular a radial shaft for a gas-turbine engine, includes a metallic and hollow shaft shank 1 with load transfer elements 2, 10, 11 integrally formed onto its ends. The shaft shank 1 includes a metal tube 3, 9 prefabricated as a semi-finished part, designed only for transmission of torsional loads and having a constant wall thickness. An outer or inner reinforcement 5, 8 intended only for ensuring the necessary bending stiffness is provided on the outer and/or inner circumferential surface of the metal tube 3, 9 and made from a fiber-composite layer 13, 13′ with fibers oriented in the longitudinal direction of the drive shaft. The inner fiber-composite layer 13 acting as outer reinforcement 5 is sheathed with an outer fiber-composite layer 14 made from fibers oriented at an angle of 60° to 90° relative to the longitudinal direction.
US08529360B2 Outer joint member for fixed constant velocity universal joint
An outer joint member for a fixed type constant velocity universal joint contributes to the reduction of the number of man-hours through the reduction of the number of processes after a forging process, to an increase in yield, and to the reduction of manufacturing cost. The outer joint member is made of machine-structural carbon steel. The portions of the outer joint member that are finished by cold forging are track grooves, radially inner spherical-surface portions, a cup-inlet chamfer, track chamfers, track-inlet chamfers, a part except for a boot fixing portion on a radially outer surface of the cup section, and a center hole at an end surface of the shaft section.
US08529356B2 Apparatus and method for adapting audio signals
A system that incorporates teachings of the present disclosure may include, for example, an audio control apparatus having a game audio port for receiving a gaming audio signal generated by a gaming application, a chat port for receiving a chat signal comprising audio information generated by at least one gamer, and an audio system coupled to the game audio port and the chat port. The audio system can be operable to detect an energy level in the chat signal that exceeds a threshold, reduce a magnitude of the gaming audio signal to a desired audio energy level responsive to the aforementioned detection, generate a mixed audio signal comprising a combination of the gaming audio signal having the reduced magnitude and the chat signal, and transmit the mixed audio signal to a listening apparatus. Additional embodiments are disclosed.
US08529354B1 System and method for facilitating data model substitutions for pre-existing data objects
The disclosure relates to systems and methods for facilitating data model substitution related to one or more pre-existing data objects in an expression of a game environment. A system may facilitate scalable addition of new game content by leveraging pre-existing data objects at a client computing platform. The system may include a game server that provides to the client computing platform data model substitutions for the existing data objects. The data model substitutions may be used to alter the behavior or function, look (e.g., visual appearance), description, and/or other characteristic of an expression of a pre-existing data object. Thus, by leveraging pre-existing data objects and providing such data model substitutions, new content or at least the appearance of new content from the user's perspective, may be provided without revising client code or requiring downloading new instructions that encode new data objects.
US08529352B2 Game system
A game system includes at least one image output device and a game apparatus. The image output device is connected to a display device via wiring. The game apparatus is capable of wirelessly communicating with the image output device and is connected via wiring to another display device different from the display device connected to the image output device. The game apparatus performs a game process and generates an image based on the game process. The generated image is displayed on the display device connected to the game apparatus. The generated image is also transmitted to the image output device. The image output device receives the image transmitted by the game apparatus. The image output device outputs the received image to the display device on which the image is displayed.
US08529351B2 System and method for playing a role-playing game
A method and apparatus for playing role-playing game is provided that involves wagering. In one example game, players subscribe to multiple game sessions and eliminate other players to become the sole survivor of the game. The players may accrue points by eliminating other players. Further, players may eliminate other players in a combat environment.
US08529343B2 Method for monitoring computer programs
As disclosed in this patent disclosure, I have invented a method for substantially disabling at least one cheat program, referred to as the anti-cheat software, used in conjunction with at least one online competitive game program involving at least two players, each player using at least one computer that are in online communication with each other. My invention allows the players' remote terminal to continue to function and operate independent of the host server, while at the same time having the host server, in conjunction with the anti-cheat software, substantially disable programs not required to operate the remote terminal and not required to play the online game—the programs that are substantially disabled may or may not be “cheat programs”, but essentially any program not required for the operation of the remote terminal and the online game.
US08529341B2 Optically sensitive display for a gaming apparatus
A gaming apparatus may include a controller operatively coupled to a display unit and a value input device. The controller may include a processor and a memory operatively coupled to the processor, and may be programmed to cause the display unit to generate a game display. The display unit may include an optically sensitive control panel operatively coupled to the controller, and the controller may be programmed to cause the optically sensitive control panel to read an image and to cause the optically sensitive control panel to generate a display of one or more game controls. An optically sensitive video display screen, and the controller may be programmed to cause the display unit to read an image via the optically sensitive video display screen and to cause the display unit to generate the game display on the optically sensitive video display screen.
US08529338B2 In-casino to online casino interactivity
A wagering game system and its operations are described herein. In embodiments, the operations can include determining an achievement by a player account that occurs during a wagering game session and rewarding the player accounts achievement according to achievement settings or business rules. The operations can also include generating achievement data with marketing metadata and providing the achievement data to a marketing provider to market to the player account based on the achievement data. In some embodiments, the operations can also include presenting the achievement data on a website, such as a personal wagering game web log “gaming blog”.
US08529337B2 Enhanced parimutuel platform for wagering
An enhanced parimutuel platform allows for the combination of multiple and single event wagers within a single pool, while maintaining payouts for the single event wagers that are independent of the multiple events. The enhanced parimutuel platform also allows for uniform payouts for wagers having a different number of outcomes for a single event, such as moneyline and point spread wagers.
US08529333B2 Replacement reel gaming device and method
Apparatuses and methods for facilitating participation in a gaming activity. A reel configuration of a plurality of reels is presented, where each of the reels includes one or more associated gaming symbols. The presentation of the gaming symbols is modified on the plurality of reels, such as by spinning the reels or otherwise changing which symbols are presented on the reels. A replacement reel is presented, to supersede or otherwise supplant at least one of the gaming symbols of the reel configuration. Results of the gaming activity are established using the gaming symbols of the plurality of reels and the replacement reel. The result is thereby based on a resulting presentation of symbols that includes both the symbols of the primary reel configuration and the symbol(s) of the replacement reel(s).
US08529331B2 Online capsule lottery system and method for same
An online capsule lottery system and method provides a lottery event in which a plurality of capsules are included in an online game. High-grade item contents having a high ability ranking in the online game is matched to at least one of the capsules, and lottery results are determined after capsules are extracted by the selection of the user. Even a player that has only recently begun playing the online game is given the opportunity to purchase a desired amount of the capsules and the chance to possess the high-grade item contents, thus enabling the player to easily become familiar with the online game. By adjusting winning odds in accordance with various ways of matching high-grade item contents with capsules, capsule purchase accumulation, and time of capsule purchase, the system and method prevent the balance of a game from being disrupted due to an indiscriminate distribution of items.
US08529325B2 Threshing bars with cutting blades and combine harvester thresher formed therewith
A combine harvester threshing drum threshing bar includes a rigid, integral, unitary threshing fixture having a leading edge and an opposed trailing end, an upstream face and an opposed downstream face formed with an oblique crop deflecting surface, a threshing side including a crop-cutting blade and a rasp structure, and an opposed threshing drum emplacement side.
US08529322B2 Method and device for processing a carcass part of slaughtered poultry
A method and device for processing a carcass-part of slaughtered poultry in a processing line is provided. Means are applied for cutting the membrana and/or removing of the wishbone from the carcass-part. The means for cutting the membrana and/or removing of the wishbone include an arrow-shaped knife and two blades arranged on opposite sides of the knife. After the means for cutting the membrana and/or removing of the wishbone are introduced into the carcass part, the arrow-shaped knife and the two blades are moved in a unitary movement from within the carcass-part in a sideways direction away from the carcass part so as to lift the wishbone legs while they are still connected to the wing joints, and subsequently turn the wishbone legs out of the wing joints of the carcass-part.
US08529320B2 Apparatus for shucking oysters
An apparatus (270) for shucking oysters includes a shucking head (272) adapted to be mounted on a mounting assembly. The shucking head includes means for supporting the oyster in a position so that a lower shell of the oyster is supported on a pair of arms (282, 284) of support members (274, 276). The shucking head also includes means for wedging the oyster in a position so that an end of the oyster is wedged against a selected wedging member (278, 280). The arrangement of support members and wedging members is such that the oyster is held in a stable position to allow a person to use a knife to shuck the oyster with one hand.
US08529315B2 Method for producing a semiconductor wafer
A method of producing a semiconductor wafer includes a plurality of steps carried out in the following order. Simultaneous double-side material-removal processing is carried out on a semiconductor wafer sliced from a single crystal by processing the semiconductor wafer between two rotating ring-shaped working disks. Each working disk includes first abrasives having an average grain size in a range of 5.0 to 20.0 μm. Both sides of the semiconductor wafer are treated with an alkaline medium. Grinding of the front and rear sides of the semiconductor wafer is carried out. For the grinding of each side a first side is held using a wafer holder and the other side is processed using a grinding tool. The grinding tool includes second abrasives having an average grain size that is smaller than the average grain size of the first abrasives and having an average grain size being in a range of 1.0 to 10.0 μm. Both sides are polished using a polishing pad including third abrasives having an average grain size in a range of 0.1 to 1.0 μm. The front side is polished using a stock removal polishing pad that is free of abrasives and a polishing agent containing fourth abrasives. The front side is then chemical mechanical polished.
US08529312B2 Nozzle for cooling lubricant
A nozzle for cooling lubricant is described having a connecting chamber with a chamber inlet and with a deflector plate in the interior of the connecting chamber that is held on at least two mounting means, a main chamber that is removably mounted by the rear face on the front face of the connecting chamber and has a diffusion plate with drilled holes, and a nozzle plate that is removably mounted by the rear face on the front face of the main chamber and has a hole pattern adapted to a grinding wheel profile.
US08529310B2 Children's riding toy having electronic sound effects
A riding toy includes a body with a spring assembly supporting the body on a base so that the body may be moved in first and second motions with respect to the base. The riding toy also includes a microcontroller and first and second motion sensors responsive to the first and second motions, respectively. The first and second motion sensors are positioned on the body and in electronic communication with the microcontroller. A sound synthesizing circuit is in electronic communication with the microcontroller and a speaker. The microcontroller is programmed to provide a first sound effect when the first motion sensor detects the first motion and a second sound effect when the second sensor detects the second motion. The first sound effect is varied based on a speed of the first motion and preempts the second sound effect if both the first and second motions are taking place simultaneously. The riding toy also includes a light sensor in electronic communication with the microprocessor. The microprocessor activates the sound synthesizing circuit to produce a third sound effect when the light sensor is triggered.
US08529308B2 Organic electroluminescence element with enhanced electron blocking characteristics and manufacturing method thereof
To improve the light emission characteristics of a device when a transition metal oxide is used for the hole injection layer, in particular, to enhance the electron blocking characteristics of a transition metal oxide. An organic electroluminescence element comprising an anode, a cathode and a plurality of functional layers formed between the anode and the cathode, the functional layer containing a layer with a light-emitting function composed of at least one kind of an organic semiconductor and, between the anode and the layer with a light-emitting function, a charge injection layer composed of at least one kind of a transition metal oxide, wherein the ratio of the metal to oxygen at the anode side of the transition metal oxide layer is smaller than the stoichiometric ratio and at the same time, the ratio of the metal to oxygen at the layer with a light-emitting function side is greater than that at the anode side.
US08529303B2 Spring contact for conducting electricity
The present invention provides a spring contact for conducting electricity, Among two side edges for conducting electricity at a cross section of each ring of the spring contact, whereinone side edge for conducting electricity has two or more contacting points, while the other side edge for conducting electricity having at least one contacting point, or a contacting line. Because at each ring cross section of the spring contact, two or more than two contacting points are secured on any side edge for conducting electricity, aim of duplicated current passing capacity is obtained. The shape of each ring cross section is changed from annular shape to other shapes whose cross section area is smaller than that of the annular shape. Therefore, the spring contact of present invention which satisfying the requirements for miniaturizing, saves materials and reduces working space occupied during its installing.
US08529300B2 Electrical connector assembly
An electrical connector assembly includes a front housing that has a mating interface. Contact modules are loaded into the front housing and extend rearward from the front housing. Each contact module has a plurality of conductors that are held by a dielectric contact module body. The conductors have mating portions that extend from the contact module body and mounting portions that extend from the contact module body. The contact modules have channels formed therein. An organizer bar is received in the channels of the contact modules. The organizer bar is manufactured from a dielectric material. The organizer bar holds the positions of the contact modules relative to one another.
US08529299B2 Connector and electronic apparatus system
A connector is disclosed. The connector includes a first connection component and a second connection component. The first connection component includes two groups of contact pins and the second connection component includes two groups of corresponding pins. The two groups of contact pins are arranged in an opposite order and the two groups of corresponding pins are also arranged in an opposite order.
US08529298B2 Electronic card connector with a releasing portion for inserting or ejecting an electronic card smoothly
An electronic card connector defining a receiving space for receiving an electronic card, includes an insulative housing, a number of contacts retain in the insulative housing, and a metal shell covering the insulative housing. The insulative housing has a bottom wall. The metal shell has a top wall opposed to the bottom wall, and a pair of side walls. The metal shell defines a depressed portion outwardly recessed from an intersection portion of the top wall and the side wall.
US08529296B2 Connector
A connector is provided, including a housing, a base, a circuit board, a receptacle, a plurality of first terminals, and a filtering element. The base is disposed in the housing and forms a recess. The circuit board is disposed at a rear side of the base. The circuit board is coupled to the recess of the base to form an accommodating space. The receptacle is formed on the housing to receive an external plug. A plurality of first terminals are disposed on the base to electrically connect to the external plug. The filtering element is disposed in the accommodating space and is electrically connected to the circuit board.
US08529293B2 Coaxial connector
A coaxial connector comprises a receptacle having an engagement hole formed inside and a plug engaging with the receptacle along an engagement axis, wherein the receptacle includes an annular receptacle external contact of which an inner peripheral surface is exposed inside the engagement hole, and a receptacle central contact having a receptacle central contact portion exposed in a direction perpendicular to the engagement axis inside the engagement hole, wherein the plug includes a plug external contact engaging with the inside of the engagement hole of the receptacle so as to be in contact with the inner peripheral surface of the annular receptacle external contact, and a cantilever-shaped plug central contact having an extension extending in a direction perpendicular to the engagement axis and a plug central contact portion positioned so as to be in contact with the receptacle central contact portion inside the engagement hole.
US08529291B2 Wall bushing plug connector and fastening element for it
A wall bushing plug connector which is to be led through and latched in a wall cutout in a housing wall, having an insulating material housing and having two sprung fastening latching arms which are arranged so as to spring outward on mutually opposite sides of the insulting material housing in opposite directions and have at least one latching edge for latching to the housing wall, and the wall bushing plug connector also having mutually opposite clamping contact sections. The sprung fastening latching arms are integrally formed on a support section opposite their free end so as to leave a clearance, with the clearance being intended to accommodate a retaining section of a mating plug connection which can be plugged onto the plug connector for connection to connection contacts.
US08529284B1 Connector locking assembly
A connector locking assembly includes a cable connector, a sleeve, and a locking device. The cable connector has a pressing plate. The sleeve includes a casing and a protective plate. The casing is connected to the rear portion of the cable connector. The protective plate extends from the casing, covers the pressing plate from above, and has a through hole. A ring set extends from the rear end of the casing. The locking device is inserted into the through hole of the protective plate for interfering with the descent of the pressing plate.
US08529283B1 Universal serial bus (USB) connector having positive retention
A lockable connector includes a receptacle having an opening located on an engagement surface and a spring clip slidably attached to the receptacle, the spring clip having a plug retention tang oriented substantially perpendicular to the opening on the engagement surface, the plug retention tang being positioned on the spring clip so that when the spring clip assumes a locking position the plug retention tang aligns with the opening located on the engagement surface of the receptacle.
US08529277B2 Flex to flex connection device
A mechanical device for electrically connecting a first flexible assembly to a second flexible assembly comprises a wafer and a housing. The wafer has an insulator core and a plurality of wafer electrical connectors. The core has a first base side and an opposed second base side. The wafer electrical connectors include a first set of wafer electrical connector contacts exposed on the first base side and a second set of wafer electrical connector contacts exposed on the second base side. The wafer electrical connector contacts are adapted to electrically connect with each of the flexible assembly electrical contacts. The housing retains the wafer, the first flexible assembly terminal, and the second flexible assembly terminal in such a way that each of the first flexible assembly electrical contacts is removably secured and electrically connected to one of the wafer electrical connector contacts.