最新美国发明专利第2013-08-06期 - 专利汇|PatentHub专利检索|专利查询网|发明专利查询分析

Document	Document Title
US08502005B1	Methods for producing linear alkylbenzenes, paraffins, and olefins from natural oils and kerosene A method for producing a linear paraffin product from natural oil and kerosene includes providing a first feed stream comprising kerosene, pre-fractionating the first feed stream to produce a heart cut paraffin stream comprising paraffins in a heart cut range, and combining the heart cut paraffin stream with a second feed stream comprising natural oil to form a combined stream. The method further includes deoxygenating the natural oil and fractionating the combined stream to remove paraffins that are heavier than the heart cut range.
US08502002B2	Microscope immersion oil Provided is an immersion oil for microscope including a liquid olefin polymer (A), a liquid diene polymer (B), a diaryl alkane (C), and an alkyl benzene (D), the immersion oil for microscope being capable of maintaining low fluorescence of its own over a long period of time, having good characteristics required for an immersion oil for microscope, such as good refractive index, Abbe number, viscosity, and resolution, and being particularly suitable as an immersion oil for a fluorescence microscope.
US08502000B2	Method of making glycerol Methods and systems for the hydroxylation of olefenic alcohols are described herein. The methods and systems incorporate the novel use of a high shear device to promote mixing and solubility of peroxides with the olefenic alcohol. The high shear device may allow for lower reaction temperatures and pressures and may also reduce hydroxylation time with existing catalysts.
US08501999B2	Hydrocarbon recovery from sulfones formed by oxidative desulfurization process The process provided herein is concerned with recovery of hydrocarbons from sulfones using an individual alkali and alkaline-earthy base and a mixture of thereof. As the starting materials are sulfones generated by ODS and commercially inexpensive alkali and alkaline-earth bases, the cost and ecological impact of solid waste disposal is minimized.
US08501998B2	Method for producing polyoxyalkylene derivative and polyoxyalkylene derivative A method for producing a polyoxyalkylene derivative represented by the following general formula (1): Z(OA)n-OH]m (1) wherein Z is a residue of glycerin or diglycerin, OA is an oxyalkylene group having 2 to 4 carbon atoms, n is an average number of moles of the oxyalkylene group added and is 80 to 800, and m is 3 to 4, the method comprising steps (A), (B), (C), (D), (E), and (F) defined in the present description.
US08501995B2	β-phenylethylidenehydrazine derivatives The present invention provides new β-phenylethylidenehydrazine derivatives, processes for preparing them and their use as pharmaceutical compostions. The β-phenylethylidenehydrazine derivatives according to the invention generally correspond to the general formula:
US08501994B2	Acetamide stereoisomer The compound of formula (I) is a water-stable, long acting β2-selective adrenoceptor agonist useful as a bronchodilator in the treatment of bronchoconstriction associated with reversible obstructive airways diseases and the like.
US08501993B2	Processes for the preparation of amides The invention relates to a process for the preparation of intermediates useful in the preparation of fungicidally active phenylpropargylether derivatives. The process involves coupling of carboxylic acid with an amine in (a) the absence of a catalyst; (b) the presence of a boronic acid catalyst.
US08501992B2	Hydroxyphenyl sulfonamides as antiapoptotic bcl inhibitors The present invention provides compound of Formula (I): or a stereoisomer, tautomer, salt or solvate thereof, wherein the variables are defined herein. The compounds of formula (I) are inhibitors of Bcl-2 family antiapoptotic proteins, compositions containing the compounds and methods of treating diseases using the compounds.
US08501991B2	P53 activating compounds The present invention relates to compounds which activate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions (involving sirtuin function).
US08501988B2	Synthesis and applications of amino carboxylates A method of synthesizing carboxylated amines is disclosed. The method comprises reacting a mixture of a potassium salt of either a primary or secondary amine with a potassium salt of a halogenated carboxylic acid wherein the halogenated carboxylic acid is selected from the group consisting of brominated, chlorinated, or iodinated carboxylic acid in the presence of potassium hydroxide, and optionally in heating the reacting mixture; precipitating the potassium salt by optionally chilling the mixture and discarding the precipitate; purifying the carboxylate amine potassium salt from the liquid phase using water soluble alcohol and optionally adding formic acid to obtain the free aminocarboxylic acid and potassium formate. In a preferred embodiment, the halogenated carboxylic acid is chloroacetic acid.
US08501986B2	Optimized liquid-phase oxidation Disclosed is an optimized process and apparatus for more efficiently and economically carrying out the liquid-phase oxidation of an oxidizable compound. Such liquid-phase oxidation is carried out in a bubble column reactor that provides for a highly efficient reaction at relatively low temperatures. When the oxidized compound is para-xylene and the product from the oxidation reaction is crude terephthalic acid (CTA), such CTA product can be purified and separated by more economical techniques than could be employed if the CTA were formed by a conventional high-temperature oxidation process.
US08501984B2	Preparation of palladium-gold catalyst A method for preparing a palladium-gold catalyst containing a titania extrudate is disclosed. The titania extrudate is produced by using a carboxyalkyl cellulose and a hydroxyalkyl cellulose as extrusion aids. The titania extrudate has improved processibility and/or mechanical properties. After calcination, the extrudate is used as a carrier for the palladium-gold catalyst. The catalyst is useful in producing vinyl acetate by oxidizing ethylene with oxygen in the presence of acetic acid.
US08501980B2	Process for producing oseltamivir phosphate and intermediate compound Disclosed are a process suited to large scale synthesis with high yield for producing oseltamivir phosphate, in which a preparation of oseltamivir phosphate which is highly safe as a pharmaceutical product can be produced, and an intermediate compound for producing oseltamivir phosphate. In this production process, an intermediate compound represented by general formula (V) is synthesized by employing Michael reaction/Michael reaction/Horner-Wadsworth-Emmons reaction, and oseltamivir phosphate is produced by converting the substituent groups in this intermediate compound.
US08501971B2	Process for the preparation of dronedarone The subject of the present invention is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide of formula I: and the new intermediates of the preparation process.
US08501966B2	Method for producing a methylene disulfonate compound The present invention provides a method for producing a methylene disulfonate compound including reacting, in the presence of an acid and a dehydrating agent, a formaldehyde compound with at least one salt of alkanedisulfonic acid selected from the group consisting of alkali metal salts of alkanedisulfonic acid and alkaline earth metal salts of alkanedisulfonic acid each represented by a specific formula. According to the method of the present invention, a methylene disulfonate compound can be obtained in a simple manner at low cost.
US08501965B2	Method for producing 3-substituted-4-fluoropyrrolidine derivative An inexpensive and industrially advantageous method for producing optically active syn-3-(N-substituted-aminomethyl)-4-fluoropyrrolidine which may be an intermediate for producing pharmaceuticals is provided. The present invention relates a method for producing a syn-1-protected-4-fluoro-3-(N-substituted-N-nitrobenzenesulfonyl)pyrrolidine derivative or it's enantiomer, or their salts comprising the process of fluorinating a compound represented by the general formula (6) (in the formula, PG1 represents a protecting group for an amino group, R1 represents a C1 to C6 alkyl group which may be substituted or a C3 to C8 cycloalkyl group which may be substituted, and Ns represents a 2-nitrobenzenesulfonyl group or a 4-nitrobenzenesulfonyl group) or it's enantiomer using a nucleophilic fluorinating agent and an organic base having an amidine or guanidine structure.
US08501962B2	Process for the preparation of high purity sunitinib and its pharmaceutically acceptable salt The present invention relates to an improved process for the preparation of N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide—Sunitinib base of formula (I) and its pharmaceutically acceptable malate salt of formula (I(a)).
US08501959B2	Cycloalkane[B]indole antagonists of prostaglandin D2 receptors Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
US08501955B2	Acetamide derivatives as glucokinase activators, their process and medicinal application Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these acetamide derivatives.
US08501951B2	Process for producing amide compound There is provided a process for producing an amide compound having an excellent harmful arthropod-controlling activity and represented by the formula (3): wherein R1, R2 and R3 independently represent a C1-C6 alkyl group optionally substituted with at least one halogen atom etc., R4, R5, R6 and R7 independently represent a halogen atom etc.
US08501950B2	N-cyanoalkylanthranilamides as insecticides Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula (I) can be used as agrochemical active ingredients and can be prepared in a manner known per se.
US08501947B2	Manufacture of 4-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and 1-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-3,3-dimethyl-piperazine The present invention relates to a process for the manufacture of 4-((1R,3S)-6-Chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine or a pharmaceutically acceptable salt thereof and a process for the manufacture of 1-((1R,3S)-6-Chloro-3-phenyl-indan-1-yl)-3,3-dimethyl-piperazine or a pharmaceutically acceptable salt thereof.
US08501946B2	5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine derivatives as P2X7 modulators The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2fluoroalkyl, halogen, NR6R7, optionally substituted heteroaryl (Het), or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis, osteoarthritis or neurodegenerative disorders.
US08501945B2	Process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate and its purification for use as pharmaceutically active compound The present invention relates to processes for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate, i.e. the compound of the formula (I) and to a process for purifying the crude product of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate sulphinyldimethane (1:2) of the formula (II) is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.
US08501940B2	Tetrahydrocinnoline derivatives Provided herein are compounds of formula (I): as well as pharmaceutically acceptable salts and esters thereof, which are useful as pharmaceutical compositions for the treatment of metabolic diseases and disorders.
US08501935B2	Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates related thereto The present invention provides processes, methods and intermediates for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, salts, hydrates and crystal forms thereof which are useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
US08501934B2	Pyrrolobenzodiazepines Methods of preparing ZC-423 (I) which result in varying enantiomeric ratios.
US08501931B2	Convertible nucleoside derivatives The present invention is directed to convertible nucleosides and polymer supported convertible nucleosides for use in SNAr displacement reactions. The convertible nucleosides can be used to synthesize numerous substituted purine and pyrimidine derivatives. An example of a polymer supported convertible nucleoside of the invention is
US08501930B2	Peptide-based in vivo siRNA delivery system The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.
US08501928B2	Chimeric promoter molecules for gene expression in prokaryotes The present invention provides regulatory polynucleotide molecules isolated from a 16S rDNA for enhanced expression of heterologous genes. The invention further discloses compositions, polynucleotide constructs, transformed host cells containing the regulatory polynucleotide sequences, and methods for preparing and using the same.
US08501926B2	Malaria vaccine The present invention features immunogenic compositions based on pre-fertilization or post-fertilization antigens expressed in the circulating gametocytes in the peripheral blood of infected persons or on the malaria parastes' stages of development in the mosquito midgut including extracellular male and female gametes, fertilized zygote and ookinete. The invention also features methods to prevent the transmission of malaria using the immunogenic compositions of the invention.
US08501925B2	Nucleic acid modules for expression and tagging of membrane proteins and methods of use Described herein are nucleic acid modules for cloning, expression and tagging of eukaryotic membrane proteins. The nucleic acid modules include a receptor for advanced glycation end products (RAGE) signal sequence, a nucleic acid sequence encoding a tag and a multiple cloning sequence (MCS). Any membrane protein of interest can be cloned into the MCS for expression in cells. The nucleic acid modules can encode any type of tag, such as an epitope tag or affinity tag. The nucleic acid modules disclosed herein can be used to express any type of membrane protein and are particularly suited to the expression and tagging of Type I and Type III membrane proteins.
US08501913B2	Spider mite silk proteins Described are silk proteins derived from spider mite, more specifically derived from Tetranychus urticae. More specifically, described is the use of these proteins to make fibers, or fiber-composed material and the resulting fibers and materials.
US08501912B2	Filipil compositions and methods for treating cancer A purified DOC1 polypeptide comprising a fragment of SEQ ID NO: 1 is provided, wherein the DOC1 polypeptide is not the full-length DOC1 polypeptide sequence. A method of inhibiting angiogenesis in a subject is provided comprising administering to a subject a nucleic acid encoding a DOC1 polypeptide, whereby a cell in the subject produces the DOC1 polypeptide, thus inhibiting angiogenesis. A method of inhibiting tumor growth in a subject is provided comprising administering to a subject a nucleic acid encoding a DOC1 polypeptide, whereby a cell in the subject produces the DOC1 polypeptide, thus inhibiting tumor growth.
US08501908B2	Immunogenic peptides The present invention relates to immunogenic peptides and their various applications. In particular the invention relates to immunogenic peptides derived from the PASD1 protein and their use in therapeutic, diagnostic and prognostic methods.
US08501905B2	Synthetic cell platforms and methods of use thereof The present invention provides synthetic cell platforms. The synthetic cell platforms can be used for culturing cells in vitro. The synthetic cell platforms can also be implanted together with bound cells into an individual. The present invention provides methods of using the platforms to provide cells or progeny of such cells for use in various applications, including clinical applications; and methods of use of the platforms to introduce cells into an individual.
US08501904B2	Method for producing polyols A process for the preparation of a polyol which includes reacting an amino-group-containing starter compound with an alkylene oxide in the presence of a catalyst to form a polyol, wherein the catalyst is based on a compound selected from the group consisting of alkali metal hydroxides, alkali, alkaline earth metal hydrides, alkaline earth metal carboxylates, and alkaline earth hydroxides, and wherein the catalyst is present in an amount of from 0.004 to 0.1 wt. % based on the amount of polyol; and neutralizing the polyol with from 0.75 to 1 mol of sulfuric acid per mol of catalyst used.
US08501892B2	Propylene ethylene polymers and production process Ethylene propylene copolymers, substantially free of diene, are described. The copolymers will have a uniform distribution of both tacticity and comonomer between copolymer chains. Further, the copolymers will exhibit a statistically insignificant intramolecular difference of tacticity. The copolymers are made in the presence of a metallocene catalyst.
US08501891B2	Ethylene-α-olefin copolymer and molded article An ethylene-α-olefin copolymer wherein the copolymer has a monomer unit based on ethylene and a monomer unit based on an α-olefin having 3 to 20 carbon atoms, the density (d) is 860 to 950 kg/m3, the melt flow rate (MFR) is 1 to 100 g/10 min, the flow activation energy (Ea) is 60 kJ/mol or more, the ratio (Mw/Mn) of the weight average molecular weight (Mw) to the number average molecular weight (Mn) is 5.5 to 30, the ratio (Mz/Mw) of the Z average molecular weight (Mz) to the weight average molecular weight (Mw) is 2 to 5, and the swell ratio (SR) is 1.55 or more and less than 1.8.
US08501888B2	Fluorine-containing polymer and surface-modifying agent containing the same as active ingredient A fluorine-containing polymer comprising a fluoroalkyl alcohol (meth)acrylic acid derivative represented by a general formula, CnF2n+1(CH2CF2)a(CF2CF2)b(CH2CH2)cOCOCR═CH2 (in the formula, R is a hydrogen atom or a methyl group, n is an integer of 1 to 6, preferably 2 to 4, a is an integer of 1 to 4, b is an integer of 0 to 3, and c is an integer of 1 to 3) containing in 5 to 100 wt % as a polymerization unit. A organic solvent solution or aqueous dispersion of the fluorine-containing polymer is effectively used as, for example, a surface-modifying agent such as a water- and oil-repellent or an oil barrier.
US08501887B2	Radical polymerizable composition A radical polymerizable composition includes a radical polymerizable compound and an organoborane-azole complex. The organoborane-azole complex includes an azole having at least two nitrogen atoms wherein at least one nitrogen atom is an sp3 nitrogen atom and is substituted. A method of forming the composition includes the step of combining the radical polymerizable compound and the organoborane-azole complex to form the composition. The method also includes the step of polymerizing the composition. A composite article which includes a substrate and a cured composition disposed on the substrate is also provided. The cured composition is formed from polymerization of the composition.
US08501883B2	Method and device for optimising catalyst supply to a polymerisation reactor Methods for supplying a catalyst to an ethylene slurry loop polymerization reactor and polymers formed therefrom are described herein. The method includes preparing a catalyst slurry in a preparation vessel. The slurry includes a hydrocarbon diluent liquid that contains a Ziegler-Natta catalyst. The catalyst slurry is supplied to a buffer vessel, withdrawn therefrom and supplied to a slurry loop polymerization reactor in which ethylene is polymerized. A co-catalyst is mixed with the Ziegler Natta catalyst in the slurry prior to supplying the catalyst slurry to the slurry loop polymerization reactor. The transfer of the catalyst slurry from the preparation vessel to the buffer vessel and the withdrawal of catalyst slurry from the buffer vessel are controlled to maintain the level of catalyst slurry in the buffer vessel substantially constant relative to the level of catalyst slurry in the preparation vessel.
US08501878B2	Method for producing polycarbonate material having excellent solubility and affinity, and contact lens material comprising the same According to the present invention, a contact lens material being excellent in oxygen permeability and transparency, being capable of undergoing injection molding, having no water content and having flexibility, as well as a contact lens gel material having excellent oxygen permeability and transparency can be provided. The present invention relates to a contact lens material comprising a polycarbonate resin derived from at least two compounds among compounds represented by a general formula (A), a general formula (B) and a general formula (C), a highly polar molecular weight control modifier (chain terminator) and a compound forming a carbonic acid ester, wherein the compound of the general formula (A) is essentially comprised, and to a production method thereof.
US08501870B2	Thermosetting resin composition of semi-IPN composite, and varnish, prepreg and metal clad laminated board using the same Provided is a thermosetting resin composition which can be used for the production of printed circuit boards, having good dielectric properties in high frequency bands so that transmission loss can be significantly lowered, having excellent heat resistance after moisture absorption and thermal expansion properties, and satisfying peeling strength between the resin composition and metal foil.The present invention relates to a thermosetting resin composition of a semi-IPN composite, comprising (A) a polyphenylene ether, and a prepolymer formed from (B) a chemically unmodified butadiene polymer containing 40% or more of a 1,2-butadiene unit having a 1 2,-vinyl group in a side chain of a molecule and (C) a crosslinking agent, in a compatibilized and uncured state; and a resin varnish, a prepreg and a metal clad laminated board using the same.
US08501863B2	Paint A paint composition and formulation for building materials, such as materials that are generally cementitious, gypsum, or of another inorganic building material, including those containing cellulose, glass, steel or polymeric fibers. The paint formulation provides improved weatherability, durability, light stability, freeze-thaw resistance and water resistivity.
US08501861B2	Polyolefin graft poly(meth)acrylate copolymer-based adhesion promoter for coating polyolefin surfaces The invention relates to a novel halogen-free and acid-free, readily soluble adhesion promoter for polyolefins, said promoter containing (meth)acrylate-grafted, amorphous polyolefins.
US08501860B2	Compositions having HASE rheology modifiers A monomer compound that contains at least one polymerizable functional group per molecule, and at least one bicycloheptyl-, bicycloheptenyl-, or branched (C5-C42)alkyl-polyether radical per molecule, wherein the bicycloheptyl- or bicycloheptenyl-polyether radical may optionally be substituted on one or more of the ring carbon atoms by one or two (C1-C6)alkyl groups per ring carbon atom is useful in making polymers, particularly pH responsive polymers.
US08501856B2	Curable silicon-containing compositions possessing high translucency The invention relates to curable, storage-stable silicon-containing compositions reinforced with functionalized silica useful as one and two-part sealant and adhesive systems. The cured compositions provide silicon-containing rubber having excellent translucency, physical properties and primerless adhesion.
US08501853B2	Aqueous adhesive for bonding elastomers An adhesive composition containing an aqueous butadiene polymer latex, and an acid scavenging compound, wherein the adhesive comprises essentially no phenolic resin or methylene donor compounds. The aqueous covercoat adhesive is particularly well suited for rubber to metal bonding applications. The adhesive have shown excellent adhesion to a number of compounds but perform best on natural rubber compounds and prefer higher cure temperatures to lower cure temperatures. Further, the formulation has been developed without the need for a methylene donor such as 2-polyoxymethylene dimethylether (gamma POM).
US08501850B2	Induced polymer assemblies The invention provides compositions and methods for inducing and enhancing order and nanostructures in block copolymers and surfactants by certain nonpolymeric additives, such as nanoparticles having an inorganic core and organic functional groups capable of hydrogen bonding. Various compositions having lattice order and nanostructures have been made from a variety of copolymers or surfactants that are mixed with nonpolymeric additives. Particularly, a variety of nanoparticles with an inorganic core and organic functional groups have been discovered to be effective in introducing or enhancing the degree of orders and nanostructures in diverse block copolymers and surfactants.
US08501849B2	Silated core polysulfides, their preparation and use in filled elastomer compositions This invention relates to novel sulfur-containing silane coupling agents, and organic polymers containing carbon-carbon double bonds. These novel silanes can be carried on organic and inorganic fillers. The invention also relates to articles of manufacture, particularly tires, made from the elastomer compositions described herein.
US08501848B2	Polycarbonate resin composition for flame retardant film, flame retardant film including the resin composition and method for producing the flame retardant film A polycarbonate resin composition for a flame retardant film includes 100 parts by weight of a polycarbonate resin, about 0.01 to about 10 parts by weight of a silicon compound, about 0.01 to about 1.5 parts by weight of an organic sulfonic acid metal salt having an average particle diameter of about 100 to about 400 μm, and about 0.01 to about 1 part by weight of a polyfluoroethylene resin.
US08501846B2	Stabilizer compositions Stabilizer compositions comprise phosphate of the formula I or II, a phosphite of the formula III, and a phenol of the formula IV as these formulas are defined herein. The stabilizer compositions are useful for stabilizing polymers. Methods for making stabilized polymer compositions involve intermixing the stabilizer compositions and the polymers, e.g., by extruding, pelletizing, and/or molding.
US08501844B2	Low migration polyolefin composition comprising vitamin E-type stabiliser The present invention relates to a polyolefin composition comprising (a) a polyolefin (A), (b) a vitamin E-type stabilizer (B) according to formula (I), wherein R1, R2, R3, R4 and R5 independently are H, or non-substituted or substituted aliphatic or aromatic hydrocarbyl radicals which may comprise heteroatoms, and (c) a phenolic stabilizer (C) according to formula (II), wherein R6, R7 and R8 independently are non-substituted or substituted aliphatic or aromatic hydrocarbyl radicals which may comprise OH-groups; and X1, X2, and X3 independently are H or OH, with the provisio that at least one of X1, X2 and X3 is OH, and (d) optionally, an UV stabilizer, to an article comprising such a polyolefin composition and to the use of such a composition for the production of an article.
US08501843B2	Optical filter An optical filter comprising at least one dye compound (i), at least one layered clay mineral (ii), and thermoplastic substance (iii) if needed. The optical filter of the present invention is excellent in light resistance and moist heat resistance and suitable for improving the image quality and preventing glare due to external light in image display devices.
US08501840B2	Water based slurry compositions for making environmental barrier coatings and environmental barrier coatings comprising the same Water based slurry compositions for making an environmental barrier coating including from about 1 wt % to about 99.9 wt % water; from about 0.1 wt % to about 72 wt % primary material; and from about 0.1 wt % to about 25 wt % slurry sintering aid.
US08501838B2	Composite wood board In a stack of composite wood boards, the wood boards comprise wood particles and an organic binder.
US08501835B2	Ink composition for roll printing An ink composition for roll printing is provided. The ink composition uses a solvent system having an evaporation rate (Vt) of at least 0.1 mg/cm2·min and an absorption rate (St) into a blanket of less than 3.412 mg/cm2·min. The use of the highly volatile solvent system can minimize swelling of the blanket without impairing the dispersibility of a pigment in the ink composition. Therefore, the uniformity of a pattern formed using the ink composition can be maintained and the formation of defects by the solvent system can be minimized.
US08501829B2	Compounds for use as ligands The present invention relates to compounds and their use as ligands, in particular in metal catalyst complexes. The ligands of the invention are capable of binding to a solid support. The invention includes the ligands in their own right and when bound to a support and the compounds may be used to prepare metal catalyst complexes.
US08501822B2	Ophthalmic composition containing alginic acid or salt thereof An ophthalmic composition that, despite containing alginic acid and/or a salt thereof, has improved tackiness during use and provides a satisfactory use feeling. The composition has an improved ability to remain on the eye mucosa. The ophthalmic composition contains (A) alginic acid and/or a salt thereof in combination with (B) hyaluronic acid and/or a salt thereof.
US08501820B2	Therapeutic formulation A pharmaceutical composition including a salt of rhodizonic acid, an OH anion-generating base, a non-toxic acid, a quinone, a salt-containing sulfite, catechol and, optionally, an acetogenin. The formulation demonstrates positive effects against cancer, autoimmune disease, viruses and provides antioxidant protection against peroxyl, hydroxyl and super oxide radicals.
US08501818B2	Stabilized compositions of alkylating agents and methods of using same Provided are stable compositions comprising alkylating agents, including nitrogen mustards, that are suitable for topical use, and methods for treating skin disorders comprising topically administering the compositions.
US08501815B2	Medicaments containing pantothenic acid This invention relates to medicaments and their use in the alleviation of inflammation and pain in joints.
US08501814B2	Selective androgen receptor modulators A compound of formula (I), an isomer, metabolite, or a pharmaceutically acceptable salt or ester thereof is disclosed. Compounds of the invention possess utility as a tissue-selective androgen receptor modulators (SARM) and are useful in hormonal therapy, e.g. in the treatment or prevention of hypogonadism, muscle wasting, osteoporosis, benign prostate hyperplasia, obesity associated with a metabolic syndrome, male and female sexual dysfunction and reduced libido, and androgen decline in aging male or female.
US08501810B2	Guanidino acetic acid used as an animal food additive The present invention relates to the use of guanidinoacetic acid and/or salts thereof as feed additive, in predominantly vegetarian diets, in particular use being made of salts with hydrochloric acid, hydrobromic acid and phosphoric acid. The use proceeds especially in individual doses from 0.01 to 100 g/kg of feed in the form of powders, granules, pastilles or capsules, the feed additive also being able to be used in combination with other physiologically active materials of value. The claimed use which is suitable especially for breeding and growing livestock, has recourse to a compound which is in particular stable in aqueous solution, can be converted to creatine under physiological conditions, and, in contrast to other guanidine derivatives, is completely available to physiological sectors of use.
US08501808B2	Foam enhancement of fatty acyl glycinate surfactants A personal care cleansing composition is provided which includes a C10-C24 acyl glycinate salt and a dihydroxypropyl quaternary ammonium salt. Most preferred is sodium cocoyl glycinate in combination with dihydroxypropyl trimethyl ammonium chloride. The quaternary ammonium salt enhances foaming properties of the glycinate salt.
US08501804B2	Bicyclic compound The present invention provides a compound having an ACC inhibitory action, which is useful as an agent for the prophylaxis or treatment of obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia, cancer and the like, and has superior efficacy.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
US08501803B2	Garcinia derivative, its preparing method and medicinal use The present invention relates to a field of pharmaceutical chemistry, more specifically, the present invention relates to a garcinia derivative Formula (I), its preparing method, and medicinal use. Wherein the definitions of R1 and R2 are disclosed in the specification of the present invention, and the derivative of the present invention is a structurally simplified analogue of the gambogic acid compound; wherein the gambogic acid compound possesses anti-cancer characteristics, and could be used for preparation of anti-tumor drugs.
US08501802B2	Co-crystals of duloxetine and COX-INHIBITORs for the treatment of pain The present invention relates to co-crystals of duloxetine and co-crystal formers selected from COX-INHIBITORs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
US08501799B2	Pharmaceutical composition containing an N-phenylpyrazole derivative, and use thereof for preparing a topical veterinary for flea control The invention relates to a liquid pharmaceutical composition that contains N-phenylpyrazole derivative as an active principle, benzyl alcohol, and an appropriately selected organic solvent, and to the use of such a composition for preparing a topically applied antiparasitic veterinary drug for preventing and/or treating flea infestation in pets, in particular, in dogs and cats.
US08501795B2	(3-aryl-1H-1,2,4-triazol-5-yl)-linked heterocycle derivatives This invention is directed to compounds of formula I having the structure which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
US08501793B2	Blood flow promoters for cauda equina tissues It is intended to provide highly safe and efficacious blood flow promoters for cauda equina tissues. Among prostaglandin-like compounds having a weak hypotensive effect, compounds having an effect of promoting the blood flow in cauda equina tissues (excluding limaprost) are useful as highly safe blood flow promoters for cauda equina tissues and, therefore, are efficacious in preventing and/or treating lumbar pain, lower limb pain, lower limb palsy, intermittent claudication, vesicorectal failure, hypogonadism, etc. caused by cauda equina injuries.
US08501788B2	Process for recovering flunixin from pharmaceutical compositions This invention is generally directed to a method for recovering flunixin and flunixin analogs from pharmaceutical compositions. The recovered flunixin and analogs can be, for example, reused to make new pharmaceutical compositions and thereby reduce the need and expense of manufacturing new flunixin and flunixin analogs.
US08501785B2	Salts of benzimidazolyl pyridyl ethers and formulations thereof Salts of benzimidazolyl pyridyl ethers are provided, particularly salts of {1-methyl-5-[2-(5-trifluoromethyl-1H-imidazol-2-yl)-pyridin-4-yloxy]-1H-benzoimidazol-2-yl}-(4-trifluoromethyl-phenyl)amine. Compositions and formulations including such salts and surfactants as well as methods of preparing such compositions and formulations are provided.
US08501784B2	2-pyridone derivatives as neutrophil elastase inhibitors and their use There are provided novel compounds of formula (I), wherein R1, R2, R4, G1, G2, L, Y and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.
US08501783B2	Conformationally restricted urea inhibitors of soluble epoxide hydrolase Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.
US08501771B2	Aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments The invention relates to aminoalcohol-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one aminoalcohol-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the aminoalcohol-substituted aryldihydroisoquinolinones of the invention and their derivatives as MCH antagonists.
US08501769B2	Thienopyridyl compounds that inhibit vanilloid receptor subtype 1 (VR1) and uses thereof The present invention discloses fused thienopyridyl compounds of general formula (I) wherein X1-X6, R5-R7, Z1 and L are as defined in the description. The resent invention also discloses a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain, urinary incontinence, bladder overactivity, and inflammatory thermal hyperalgesia in mammals, and pharmaceutical compositions including those compounds.
US08501763B2	Inhibitors of focal adhesion kinase The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.
US08501762B2	Tetrahydroprotoberberine compounds, the synthetic method and the use thereof The present invention relates to tetrahydroprotoberberines of the formula (I) and the physiologically acceptable salts thereof. The invention also relates to the use of the compounds of the formula (I) or pharmaceutically acceptable salts thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with dopamine receptor ligand, such as schizophrenia.
US08501758B2	Compounds and compositions as protein kinase inhibitors The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
US08501756B2	Heterobicyclic carboxamides as inhibitors for kinases The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.
US08501754B2	Quinazolinamide derivatives Novel quinazolinamide derivatives of the formula (I), in which R1-R3 have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
US08501753B2	Useful pharmaceutical salts of 7-[(3R, 4R)-3-Hydroxy-4-hydroxymethyl-pyrrolidin-1-ylmethyl]-3, 5-dihydro-pyrrolo [3, 2-D] pyrimidin-4-one The present disclosure provides novel hemi- and mono-salts of 7-[(3R,4R)-3-Hydroxy-4-hydroxymethyl-pyrrolidin-1-ylmethyl]-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one (Compound 1) with various organic and inorganic acids. In one embodiment, the organic acid is a C4 organic diacids. The present disclosure further provides novel methods for preparing these salts. The novel monohydrates hemisalts of the C4 organic diacids are isostructural and can be prepared with different properties. Multiple acids can be used simultaneously and the proportion of acids can be varied offering the opportunity to select hemi-salts of compound 1 with desired properties.
US08501752B2	Methods for treating cancer and other pathological proliferating disorders by inhibiting mitosis using pyrrolo[2,3-d]pyrimidines The present invention provides methods for treating cancer and other pathological proliferating conditions by inhibiting mitosis using at least one pyrrolo[2,3-d]pyrimidine having the general formula (16): where X is selected from the group consisting of lower alkyls, heteroalkyls, substituted or unsubstituted aryls or heteroaryls, arylalkyls, and heteroarylalkyls; where R1 is selected from the group consisting of hydrogen, lower alkyls, heteroalkyls, substituted or unsubstituted aryls or heteroaryls, arylalkyls, and heteroarylalkyls; where R2 is selected from the group consisting of hydrogen, lower alkyls, heteroalkyls, alkoxys, substituted or unsubstituted aryls or heteroaryls; where R3 is selected from the group consisting of zero, lower alkyls, heteroalkyls, alkenyls, and heteroalkenyls; and where R4 is selected from the group consisting of substituted or unsubstituted aryls or heteroaryls, arylalkyls, heteroarylalkyls, and hydrogen. The compound may inhibit mitosis in cells that have developed multidrug resistance due to P-glycoprotein and MRP1, and facilitate the reversal of P-glycoprotein mediated resistance.
US08501750B2	Heterocyclic compound and use thereof Heterocyclic compounds, pharmaceutical agent and methods thereof, having superior pharmacological action and/or physicochemical properties, which are useful for the prophylaxis or treatment of circulatory diseases such as hypertension, cardiac diseases, arteriosclerosis, renal diseases and cerebral apoplexy and/or metabolic diseases such as hyperlipidemia, obesity and diabetes and/or central nervous disorders such as cerebral infarction, and/or mental diseases such as dementia depression and depression.
US08501748B2	Method for the production of β-ketonitriles The present invention relates to a process for preparing β-ketonitriles of the general formula I in which R1 is, inter alia, C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkinyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl-C1-C4-alkyl, phenoxy-C1-C4-alkyl or benzyloxy-C1-C4-alkyl; R2 is, inter alia, hydrogen, C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkinyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl, phenyl-C1-C4-alkyl, phenoxy-C1-C4-alkyl or benzyloxy-C1-C4-alkyl, which comprises reacting a nitrile of the formula II in which R1 has one of the meanings given above with a carboxylic ester of the formula III in which R2 has one of the meanings given above and R3 is C1-C12-alkyl, C1-C4-alkoxy-C1-C4-alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl-C1-C4-alkyl, phenoxy-C1-C4-alkyl or benzyloxy-C1-C4-alkyl, where the reaction is carried out in the presence of a potassium alkoxide and at least 80% of the nitrile of the formula II are added to the reaction under reaction conditions.
US08501747B2	Functionally selective alpha2C adrenoreceptor agonists In its many embodiments, the present invention provides a novel class of biaryl compounds as inhibitors of ÿ2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the ÿ2C adrenergic receptors using such compounds or pharmaceutical compositions.
US08501743B2	Personal care composition A personal care composition comprising a eutectic mixture, the eutectic mixture comprising a tertiary system, in which menthol may form part of the eutectic mixture or in the eutectic mixture comprises an antidandruff agent such as ketoconazole.
US08501742B2	Method of treating panic disorder The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT1A receptor subtype, comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1): wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond.
US08501732B2	Aminomethyl quinolone compounds The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula I: wherein the variables are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
US08501731B2	Derivatives of 6[3-(trifluoromethyl)phenyl]pyridazin-3(2H)-one having antitumor activity The present invention relates to a class of pyridazinones of formula I, which comprises 6-[3-(trifluoromethyl)phenyl]pyridazin-3(2H)-one as a mother nucleus, the preparation method thereof and the use thereof in manufacturing medicaments against tumors, especially liver cancer.
US08501730B2	Process for preparing benzazepine compounds or salts thereof This invention provides a process for preparing benzazepine compounds of the formula (1): wherein X1 is a halogen atom, R1 and R2 are a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and high purity on industrial scale, which are useful as an intermediate for preparing a pharmaceutically active 2,3,4,5-tetrahydro-1H-1-benzazepine compound having vasopressin antagonistic activity.
US08501725B2	Synergistic combination of flumetsulam or diclosulam with zinc pyrithione A synergistic antimicrobial composition containing flumetsulam or diclosulam; and zinc pyrithione.
US08501712B2	Boron-containing small molecules as anti-inflammatory agents Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
US08501706B2	Duplex oligonucleotide complexes and methods for gene silencing by RNA interference Provided herein are duplex oligonucleotide complexes which can be administered to a cell, tissue or organism to silence a target gene without the aid of a transfection reagent(s). The duplex oligonucleotide complexes of the disclosure include a conjugate moiety that facilitates delivery to a cell, tissue or organism.
US08501705B2	Methods and materials for treating autoimmune and/or complement mediated diseases and conditions Disclosed are methods for treating an autoimmune and/or complement mediated disease or condition in a subject. The methods include administering to the subject a compound which inhibits the subject's classical complement pathway. The methods include administering to the subject a compound which inhibits the subject's classical complement pathway. Compositions which include inhibitors of C1q, C1r, C1s, C2 or C4 and a pharmaceutically acceptable excipient are also described.
US08501704B2	Immunosuppression compound and treatment method Provided are methods and antisense oligonucleotide analogs for suppressing an immune response in a mammalian subject, for the treatment or prevention of an autoimmune condition or transplantation rejection. The oligonucleotide analogs provided herein comprise a targeting sequence complementary to a preprocessed CTLA-4 mRNA region that spans the splice junction between intron 1 and exon 2 of the preprocessed CTLA-4 mRNA. Also provided are methods of use, in which the oligonucleotides are effective, when administered to a subject, to form within host cells, a heteroduplex structure (i) composed of the preprocessed CTLA-4 mRNA and the oligonucleotide compound, (ii) characterized by a Tm of dissociation of at least 45° C., and (iii) resulting in an increased ratio of processed mRNA encoding ligand-independent CTLA-4 to processed mRNA encoding full-length CTLA-4.
US08501703B2	Chimeric oligomeric compounds for modulation of splicing Disclosed herein are compounds, compositions and methods for modulating splicing of a selected target mRNA. Further provided are uses of the disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Methods of enhancing cellular uptake, modulating tissue distribution and enhancing pharmacological activity of RNase H-independent antisense oligonucleotides are also provided.
US08501702B2	Overexpression of Wnt ligands and treatment of lytic bone diseases The present invention is drawn to methods of repairing lytic bone lesions and tumor growth in an individual. In this regard, the present invention discloses use of a Wnt ligand either alone or in combination with anti-Wnt signaling antagonist therapy. The individuals who might benefit from such method may include but are not limited to the ones with multiple myeloma, osteoporosis, post-menopausal osteoporosis, fractures, metastatic breast cancer or metastatic prostate cancer.
US08501701B2	Use of lipid conjugates in the treatment of disease The invention relates to methods of use for compounds in treating, reducing the incidence, reducing the severity or pathogenesis of an intestinal disease or condition in a subject, including, inter alia, inflammatory bowel disease, Crohn's disease, ulcerative colitis, or a combination thereof.
US08501700B2	Method to enhance delivery of glutathione and ATP levels in cells A therapeutic method is provided comprising treating a mammal subject to hypoxia with an amount of 2(R,S)-D-ribo-(1′,2′,3′,4′-tetrahydroxybutyl)thiazolidine-4(R)-carboxylic acid (RibCys) or a pharmaceutically acceptable salt thereof effective to both maintain, restore or increase both the ATP levels and the glutathione (GSH) levels in said tissue.
US08501696B2	Soluble GP130 muteins with improved binding activity Described are soluble gp130 polypeptide monomers and dimers, wherein, in a preferred embodiment, at least one of the three amino acid residues Thr102 Gln113 or Asn114 of the N-terminal Ig-like domain of gp130 is mutated to Tyr102, Phe113 or Leu114, respectively. These mutations, alone or in combination, specifically enhance binding of gp130 to its ligand complex of interleukin-6 and soluble interleukin-6 receptor, thus increasing the biological activity of the gp130 muteins. In a particularly preferred embodiment, all three mutations are combined in the triple mutein Thr102Tyr/Gln113Phe/Asn114Leu (T102Y/Q113F/N114L). Moreover, a pharmaceutical composition containing said monomers or dimers and various medical uses are described.
US08501692B2	Compositions and methods for altering cocaine esterase activity The present invention relates to compositions and methods for treating and preventing cocaine addiction. In particular, the present invention provides mutated cocaine esterase proteins for use in treating and preventing cocaine addiction.
US08501689B2	Growth factor-mimicking peptides and uses thereof The present invention relates to a growth factor-mimicking peptide having an activity of the growth factor, and a composition and a method for improving skin conditions or for treating a wound using the same. The growth factor-mimicking peptides of this invention have identical functions or actions to natural-occurring human growth factor, and much better stability and skin penetration potency than natural-occurring growth factor. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding growth factor activities. In addition, excellent activity and stability of the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.
US08501682B2	Difluorinated tripeptides as HCV serine protease inhibitors The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
US08501678B2	Variant activin receptor polypeptides and uses thereof The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
US08501677B2	Methods and compositions for modulating T cell and/or B cell activation The present invention provides methods of reducing or enhancing T cell activation and/or B cell activation in a subject, comprising administering to a subject an effective amount of an inhibitor or enhancer, respectively, of Semaphorin 6D (Sema6D) activity on T cells and/or B cells.
US08501676B2	Preparation for use of aspartate for regulating glucose levels in blood The invention relates to the use of specific protein and/or peptide fractions having a high aspartate content for regulating plasma glucose concentrations and increasing insulin sensitivity in a mammal. The invention relates to a complete food fortified with aspartate equivalents as well as a supplement rich in aspartate equivalents that is given simultaneously with or even minutes up to an hour prior to the consumption of a meal comprising glucose. The nutritional or pharmaceutical composition contains at least one protein having a high aspartate content, preferably of soy or dairy origin, which is further enriched with aspartate equivalents from another protein and/or free aspartate equivalents. The protein fraction comprises glutamate equivalents in a weight ratio of aspartate equivalents to glutamate equivalents (asp:glu) between 0.41:1 and 5:1.
US08501674B2	Amine derivatives as friction modifiers in lubricants A composition useful for lubricating an automatic transmission comprises an oil of lubricating viscosity and a hydrocarbyl amine with a hydrocarbyl group of 12 to 22 carbon atoms and having one or two additional groups of the structure —R3—NHC(O)R4, wherein R3 is an alkylene group of 1 to 4 carbon atoms and R4 is a hydrocarbyl group of 4 to 22 carbon atoms, or a nitrogen-containing heterocyclic group, or an aminoalkyl group.
US08501669B2	Systems and methods of screening biomarkers in bodily fluids Systems and methods of screening biomarkers in bodily fluids. According to at least one embodiment of the system for analyzing stabilizing agents of the present disclosure, the system comprises a detection platform comprising a plurality of detection sites each capable of receiving a diagnostic marker, a stabilization agent, and a detection agent. The system, in at least one embodiment, further comprises a detection device capable of determining a binding characteristic between the detection agent and the diagnostic marker in the detection sites. Further, the system may also be able to compare the binding characteristic among a plurality of detection markers to order the level of effect of the stabilizing agents assayed on the binding characteristic between the detection agent and the diagnostic agent.
US08501668B2	Drug screening via nanopore silicon filters The invention provides a porous nanoscale membrane. In one embodiment, the membrane can be used as a filtration device to screen agents that disrupt or prevent molecular interactions. In one embodiment, the membrane allows for screening agents that disrupt or prevent molecular interactions using a small sample volume with efficient high-throughput screening applications.
US08501667B2	Water-based herbicidal suspension Not so many reports on the practical use of herbicidal sulfonylurea compounds have been made since they easily decompose in water or a process for production of their suspensions is complicated. Therefore, it is desired to prepare a water-based herbicidal suspension in which a herbicidal sulfonylurea compound will not decompose in water and excellent suspensibility of which is maintained, without complicated process. A water-based herbicidal suspension comprising (1) a herbicidal sulfonylurea compound (excluding 1-[3-[(4,6-dimethoxypyrimidin-2-ylcarbamoyl)sulfamoyl]-2-pyridyl]-2-fluoropropyl methoxyacetate and N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(2-fluoro-1-hydroxypropyl)-3-pyridinesulfonamide) or its salt, (2) an inorganic salt, (3) at least one sulfonate selected from the group consisting of an aryl sulfonate, an alkylaryl sulfonate and their formaldehyde condensates and (4) water.
US08501665B2	Method for manufacturing film catalyst The present invention provides a method for manufacturing a film catalyst, including forming a catalyst layer on one side or each side of a base material to obtain a film catalyst, bending the film catalyst, and optionally cutting the film catalyst, wherein the bending step is conducted by bending the film catalyst with a bending tool composed of two gears that are oppositely arranged as meshing each other while a protective material having a compressibility of 40 to 95% is inserted between the catalyst layer of the film catalyst and the two gears.
US08501662B2	Catalyst material In a ceramic honeycomb structure, a catalyst material used for burning soot discharged from an internal combustion engine is supported on partition walls that are inner surfaces of cells. For example, a catalyst material to be used for burning carbon includes silver and alumina as components, and the catalyst material has a dumbbell-shaped O—Ag—O structure. Thus, the ceramic honeycomb structure can burn soot at low temperature using the supported catalyst material without corroding the honeycomb structure.
US08501660B2	Catalyst additives A nickel slurry comprising a nickel catalyst, water and at least one rheology modifier, the activity of the nickel catalyst being equal to or greater than the activity of the equivalent nickel catalyst contained in a slurry which does not comprise rheology modifiers, wherein the at least one rheology modifier provides high viscosity at low shear stress and low viscosity at high shear stress.
US08501651B2	Catalyst systems and polymer resins having improved barrier properties A catalyst system comprising a half-sandwich chromium complex, an activator support and an optional cocatalyst. A compound of formula Cp′Cr(Cl)2(Ln), where Cp′ is η5—C5H4CH2CH2CH═CH2 and Ln is pyridine, THF or diethylether. A compound of formula Cp″Cr(Cl)2(Ln), where Cp″ is η5—C5H4C(Me)2CH2CH2CH═CH2 and Ln is pyridine, THF or diethylether.
US08501646B2	Non-woven fabric laminate A non-woven fabric laminate that is excellent in strechability, flexibility, and bulkiness, and that is less sticky and is suitable for a mechanical fastening female material. The non-woven fabric laminate includes a mixed fiber spunbonded non-woven fabric and a non-woven fabric comprising a crimped fiber that is laminated on at least one face of the mixed fiber spunbonded non-woven fabric, which includes a continuous fiber of a thermoplastic elastomer (A) in the range of 10 to 90% by weight and a continuous fiber of a thermoplastic resin (B) in the range of 90 to 10% by weight (where (A)+(B)=100% by weight). The non-woven fabric laminate can be suitably used for a sanitary material and other materials. More specifically, there can be mentioned for instance an absorbent article such as a disposable diaper and a menstrual sanitary product as a sanitary material.
US08501639B2	Thermally protective flame retardant fabric A thermally protective, flame retardant fabric includes a substrate treated with a combination of a flame retardant agent and an intumescent agent. The substrate includes non-thermoplastic fibers or a blend of non-thermoplastic fibers and thermoplastic fibers having a basis weight ranging from 2.0 to 15.0 ounces per square yard. The fabric has a contact thermal protective performance value of at least 4.5 and a contact thermal protective performance efficiency greater than 1.1. Applications of the fabric include protective garments, articles of furniture, vehicle components, building components, electrical components, decorative components, appliances, and containers.
US08501637B2	Silicon dioxide thin films by ALD Methods are provided for depositing silicon dioxide containing thin films on a substrate by atomic layer deposition ALD. By using disilane compounds as the silicon source, good deposition rates and uniformity are obtained.
US08501636B1	Method for fabricating silicon dioxide layer A method for fabricating silicon dioxide layer is disclosed. The method includes the following steps. Firstly, a semiconductor substrate is provided. Next, the semiconductor substrate is cleaned with a solution containing hydrogen peroxide to form a chemical oxide layer on the semiconductor substrate. Then, the chemical oxide layer is heated in no oxygen atmosphere, such that the chemical oxide layer forms a compact layer. Then, the semiconductor substrate is heated in oxygen atmosphere to form a silicon dioxide layer between the semiconductor substrate and the compact layer.
US08501632B2	Methods of fabricating isolation regions of semiconductor devices and structures thereof Methods of fabricating isolation regions of semiconductor devices and structures thereof are disclosed. A preferred embodiment includes forming at least one trench in a workpiece, and forming a thin nitride liner over sidewalls and a bottom surface of the at least one trench and over a top surface of the workpiece using atomic layer deposition (ALD). An insulating material is deposited over the top surface of the workpiece, filling the at least one trench. At least a portion of the insulating material is removed from over the top surface of the workpiece. After removing the at least a portion of insulating material from over the top surface of the workpiece, the thin nitride liner in the at least one trench is at least coplanar with the top surface of the workpiece. The thin nitride liner and the insulating material form an isolation region of the semiconductor device.
US08501630B2	Selective etch process for silicon nitride A method for selectively etching a substrate is described. The method includes preparing a substrate comprising a silicon nitride layer overlying a silicon-containing contact region, and patterning the silicon nitride layer to expose the silicon-containing contact region using a plasma etching process in a plasma etching system. The plasma etching process uses a process composition having as incipient ingredients a process gas containing C, H and F, and a non-oxygen-containing additive gas, wherein the non-oxygen-containing additive gas includes H, or C, or both H and C, and excludes a halogen atom.
US08501629B2	Smooth SiConi etch for silicon-containing films A method of etching silicon-containing material is described and includes a SiConi™ etch having a greater or lesser flow ratio of hydrogen compared to fluorine than that found in the prior art. Modifying the flow rate ratios in this way has been found to reduce roughness of the post-etch surface and to reduce the difference in etch-rate between densely and sparsely patterned areas. Alternative means of reducing post-etch surface roughness include pulsing the flows of the precursors and/or the plasma power, maintaining a relatively high substrate temperature and performing the SiConi™ in multiple steps. Each of these approaches, either alone or in combination, serve to reduce the roughness of the etched surface by limiting solid residue grain size.
US08501628B2	Differential metal gate etching process A method for etching a differential metal gate structure on a substrate is described. The differential metal gate structure includes a metal gate layer overlying a high dielectric constant (high-k) dielectric layer, wherein the metal gate layer comprises a different thickness at different regions on the substrate. The metal gate layer is patterned by using a plasma etching process, wherein at least one etch step includes forming plasma using a halogen-containing gas and at least one etch step includes forming plasma using an additive gas having as atomic constituents C, H, and F.
US08501613B2	UBM etching methods for eliminating undercut A method includes forming an under-bump metallurgy (UBM) layer overlying a substrate, and forming a mask overlying the UBM layer. The mask covers a first portion of the UBM layer, and a second portion of the UBM layer is exposed through an opening in the mask. A metal bump is formed in the opening and on the second portion of the UBM layer. The mask is then removed. A laser removal is performed to remove a part of the first portion of the UBM layer and to form an UBM.
US08501609B2	Method for generating a three-dimensional NAND memory with mono-crystalline channels using sacrificial material A method for generating three-dimensional (3D) non-volatile memory (NVM) arrays includes forming multiple parallel horizontally-disposed mono-crystalline silicon beams that are spaced apart and arranged in a vertical stack (e.g., such that an elongated horizontal air gap is defined between each adjacent beam in the stack), forming separate charge storage layers on each of the mono-crystalline silicon beams such that each charge storage layer includes a high-quality thermal oxide layer that entirely covers (i.e., is formed on the upper, lower and opposing side surfaces of) each of the mono-crystalline silicon beams, and then forming multiple vertically-disposed poly-crystalline silicon wordline structures next to the stack such that each wordline structure is connected to each of the bitline structures in the stack by way of corresponding portions of the separate charge storage layers. The memory cells are accessed during read/write operations by way of the corresponding wordline and bitline structures.
US08501606B2	Methods of forming wiring structures A semiconductor memory wiring method includes: receiving a substrate having a cell array region and a peripheral circuit region; depositing a first insulating layer on the substrate; forming a first contact plug in the cell array region, the first contact plug having a first conductive material extending through the first insulating layer; forming a first elongated conductive line at substantially the same time as forming the first contact plug, the first elongated conductive line having the first conductive material directly covering and integrated with the first contact plug; forming a second contact plug in the peripheral circuit region at substantially the same time as forming the first contact plug, the second contact plug having the first conductive material extending through the first insulating layer; and forming a second elongated conductive line at substantially the same time as forming the second contact plug, the second elongated conductive line having the first conductive material directly covering and integrated with the second contact plug.
US08501605B2	Methods and apparatus for conformal doping Methods and apparatus for processing a substrate are provided herein. In some embodiments, a method of doping a substrate may include forming a dopant region on a substrate by implanting one or more dopant elements into the dopant region of the substrate using a plasma doping process; forming a cap layer atop the dopant region; annealing the dopant region after forming the cap layer; and removing the cap layer after annealing the dopant region.
US08501593B2	Method of NiSiGe epitaxial growth by introducing Al interlayer The present invention discloses a method of NiSiGe epitaxial growth by introducing Al interlayer, comprising the deposition of an Al thin film on the surface of SiGe layer, subsequent deposition of a Ni layer on Al thin film and then the annealing process for the reaction between Ni layer and SiGe material of SiGe layer to form NiSiGe material. Due to the barrier effect of Al interlayer, NiSiGe layer features a single crystal structure, a flat interface with SiGe substrate and a thickness of up to 0.3 nm, significantly enhancing interface performance.
US08501591B2	Method for manufacturing a multiple-bit-per-cell memory A method for manufacturing an electrically programmable non-volatile memory cell comprises forming a first electrode on a substrate, forming an inter-electrode layer of material on the first electrode having a property which is characterized by progressive change in response to stress, and forming a second electrode over the inter-electrode layer of material. The inter-electrode layer comprises a dielectric layer, such as ultra-thin oxide, between the first and second electrodes. A programmable resistance, or other property, is established by stressing the dielectric layer, representing stored data. Embodiments of the memory cell are adapted to store multiple bits of data per cell and/or adapted for programming more than one time without an erase process.
US08501588B2	Method for making a semiconductor structure with a buried ground plane A method for making a semiconducting structure, including: a) forming, on a surface of a final semiconductor substrate, a semiconducting layer, doped with elements from columns III and V of the Periodic Table so as to form a ground plane, b) forming a dielectric layer, c) then assembling, by direct adhesion of the source substrate, on the final substrate, the layer forming the ground plane between the final substrate and the source substrate, the dielectric layer being between the source substrate and the ground plane, d) then thinning the source substrate, leaving, on the surface of the semiconductor structure, a film made from a semiconducting material.
US08501586B2	Power semiconductor In order to produce a power semiconductor for operation at high blocking voltages, there is produced on a lightly doped layer having a doping of a first charge carrier type a medium-doped layer of the same charge carrier type. A highly doped layer is produced at that side of the medium-doped layer which is remote from the lightly doped layer, of which highly doped layer a part with high doping that remains in the finished semiconductor forms a second stop layer, wherein the doping of the highly doped layer is higher than the doping of the medium-doped layer. An electrode is subsequently indiffused into the highly doped layer. The part with low doping that remains in the finished semiconductor forms the drift layer and the remaining medium-doped part forms the first stop layer.
US08501580B2	Process of fabricating semiconductor device with low capacitance for high-frequency circuit protection A process for fabricating a semiconductor device includes depositing n-type dopant on a p-type substrate, implanting n-type material into the substrate, and growing an n-type epitaxial layer atop the n+ layer. Trenches surrounding the device region are formed and an n+ layer on the sidewalls of the trenches is formed. The trenches are filled by growing a layer of thermal oxide on the sidewalls of the trenches and deposition of plasma enhanced oxide or polysilicon into the trenches, and planarizing the top surface. n+ region of the device is formed by forming an oxide layer on the top surface of the device layer and etching the oxide, depositing n-type dopant material and driving in by high temperature diffusion. p+ region of the device is formed by etching the oxide, depositing p-type dopant material and driving in by high temperature diffusion so that the breakdown voltage is set for circuit protection.
US08501575B2	Method of forming multilayer capacitors in a printed circuit substrate Methods of forming embedded, multilayer capacitors in printed circuit boards wherein copper or other electrically conductive channels are formed on a dielectric substrate. The channels may be preformed using etching or deposition techniques. A photoimageable dielectric is an upper surface of the laminate. Exposing and etching the photoimageable dielectric exposes the space between the copper traces. These spaces are then filled with a capacitor material. Finally, copper is either laminated or deposited atop the structure. This upper copper layer is then etched to provide electrical interconnections to the capacitor elements. Traces may be formed to a height to meet a plane defining the upper surface of the dielectric substrate or thin traces may be formed on the remaining dielectric surface and a secondary copper plating process is utilized to raise the height of the traces.
US08501573B2	High-resolution integrated X-ray CMOS image sensor An X-ray image sensor having scintillating material embedded into wave-guide structures fabricated in a CMOS image sensor (CIS). After the CIS has been fabricated, openings (deep pores) are formed in the back side of the CIS wafer. These openings terminate at a distance of about 1 to 5 microns below the upper silicon surface of the wafer. The depth of these openings can be controlled by stopping on a buried insulating layer, or by stopping on an epitaxial silicon layer having a distinctive doping concentration. The openings are aligned with corresponding photodiodes of the CIS. The openings may have a shape that narrows as approaching the photodiodes. A thin layer of a reflective material may be formed on the sidewalls of the openings, thereby improving the efficiency of the resulting waveguide structures. Scintillating material (e.g., CsI(Tl)) is introduced into the openings using a ForceFill™ technology or by mechanical pressing.
US08501571B2	Method of manufacturing semiconductor device having silicon carbide layers containing phosphorus A semiconductor device includes a MOS transistor, a source electrode and a drain electrode on the MOS transistor each include a first carbon doped silicon layer including carbon at a first carbon concentration and phosphorus at a first phosphorus concentration and a second carbon doped silicon layer over the first silicon carbide layer, which includes phosphorus at a second phosphorus concentration higher than the first phosphorus concentration, and which includes carbon at a second carbon concentration less than or equal to the first carbon concentration.
US08501569B2	Semiconductor device having gradient doping profile The present disclosure provides a method of fabricating a semiconductor device. The method includes forming a gate over a substrate. The method includes performing a first implantation process to form a first doped region in the substrate, the first doped region being adjacent to the gate. The method includes performing a second implantation process to form a second doped region in the substrate, the second doped region being formed farther away from the gate than the first doped region, the second doped region having a higher doping concentration level than the first doped region. The method includes removing portions of the first and second doped regions to form a recess in the substrate. The method includes epitaxially growing a third doped region in the recess, the third doped region having a higher doping concentration level than the second doped region.
US08501567B2	Manufacturing method of high voltage device The present invention discloses a manufacturing method of a high voltage device. The high voltage device is formed in a first conductive type substrate. The high-voltage device includes: a second conductive type buried layer; a first conductive type high voltage well; and a second conductive type body. The high voltage well is formed by the same step for forming a first conductive type well or a first conductive type channel stop layer of a low voltage device formed in the same substrate. The body is formed by the same step for forming a second conductive type well of the low voltage device.
US08501564B2	Semiconductor element, semiconductor device, and method for manufacturing the same The semiconductor element includes an oxide semiconductor layer on an insulating surface; a source electrode layer and a drain electrode layer over the oxide semiconductor layer; a gate insulating layer over the oxide semiconductor layer, the source electrode layer, and the drain electrode layer; and a gate electrode layer over the gate insulating layer. The source electrode layer and the drain electrode layer have sidewalls which are in contact with a top surface of the oxide semiconductor layer.
US08501561B2	Method for producing a semiconductor component arrangement comprising a trench transistor Disclosed is a semiconductor component arrangement and a method for producing a semiconductor component arrangement. The method comprises producing a trench transistor structure with at least one trench disposed in the semiconductor body and with at least an gate electrode disposed in the at least one trench. An electrode structure is disposed in at least one further trench and comprises at least one electrode. The at least one trench of the transistor structure and the at least one further trench are produced by common process steps. Furthermore, the at least one electrode of the electrode structure and the gate electrode are produced by common process steps.
US08501558B2	Semiconductor device and manufacturing method of the same Manufacturing technique for a semiconductor device having a first MISFET of an n channel-type and a second MISFET of a p channel type, including forming a first insulating film composed of a silicon oxide film or a silicon oxynitride film on a semiconductor substrate for forming a gate insulating film of the respective MISFETs; depositing metal elements on the first insulating film; forming of a silicon film on the first insulating film for the forming of a gate electrode of the respective MISFETs; and producing the respective gate electrodes by patterning the silicon film. The depositing of the metal films on the first insulating film is such that there is produced in the vicinity of the interface between the gate electrode and the gate insulating film a surface density of the metal elements within a range of 1×1013 to 5×1014 atoms/cm2.
US08501555B2	Semiconductor device and manufacturing method thereof It is an object of the present invention to provide a thin film transistor in which an oxide semiconductor film containing indium (In), gallium (Ga), and zinc (Zn) is used and contact resistance of a source or a drain electrode layer is reduced, and a manufacturing method thereof. An IGZO layer is provided over the source electrode layer and the drain electrode layer, and source and drain regions having lower oxygen concentration than the IGZO semiconductor layer are intentionally provided between the source and drain electrode layers and the gate insulating layer, so that ohmic contact is made.
US08501554B2	Methods for manufacturing thin film transistor and display device The present invention provides a method for manufacturing a highly reliable semiconductor device with a small amount of leakage current. In a method for manufacturing a thin film transistor, etching is conducted using a resist mask to form a back channel portion in the thin film transistor, the resist mask is removed, a part of the back channel is etched to remove etching residue and the like left over the back channel portion, whereby leakage current caused by the residue and the like can be reduced. The etching step of the back channel portion can be conducted by dry etching using non-bias.
US08501550B2	Method of fabricating gate and method of manufacturing semiconductor device using the same A method of fabricating a gate includes sequentially forming an insulation layer and a conductive layer on substantially an entire surface of a substrate. The substrate has a device isolation layer therein and a top surface of the device isolation layer is higher than a top surface of the substrate. The method includes planarizing a top surface of the conductive layer and forming a gate electrode by patterning the insulation layer and the conductive layer.
US08501546B2	Stacked microelectronic devices and methods for manufacturing stacked microelectronic devices Stacked microelectronic devices and methods of manufacturing stacked microelectronic devices are disclosed herein. In one embodiment, a method of manufacturing a microelectronic device includes forming a plurality of electrically isolated, multi-tiered metal spacers on a front side of a first microelectronic die, and attaching a back-side surface of a second microelectronic die to individual metal spacers. In another embodiment, the method of manufacturing the microelectronic device may further include forming top-tier spacer elements on front-side wire bonds of the first die.
US08501545B2	Reduction of mechanical stress in metal stacks of sophisticated semiconductor devices during die-substrate soldering by an enhanced cool down regime In a reflow process for connecting a semiconductor die and a package substrate, the temperature gradient and thus the thermally induced mechanical forces in a sensitive metallization system of the semiconductor die may be reduced during the cooling phase. To this end, one or more heating intervals may be introduced into the cooling phase, thereby efficiently reducing the temperature difference. In other cases, the central region may additionally be cooled by providing appropriate locally restricted mechanisms, such as a locally restricted gas flow and the like. Consequently, desired short overall process times may be obtain without contributing to increased yield losses when processing sophisticated metallization systems on the basis of a lead-free contact regime.
US08501544B2	Semiconductor device and method of forming adhesive material over semiconductor die and carrier to reduce die shifting during encapsulation A semiconductor device has a plurality of semiconductor die mounted to a carrier. An adhesive material is deposited over a portion of the semiconductor die and carrier to secure the semiconductor die to the carrier. The adhesive material is deposited over a side of the semiconductor die and over a surface of the carrier. The adhesive material can be deposited over a corner of the semiconductor die, or over a side of the semiconductor die, or around a perimeter of the semiconductor die. An encapsulant is deposited over the semiconductor die and carrier. The adhesive material reduces shifting of the semiconductor die with respect to the carrier during encapsulation. The adhesive material is cured and the carrier is removed. The adhesive material can also be removed. An interconnect structure is formed over the semiconductor die and encapsulant. The semiconductor die are singulated through the encapsulant and interconnect structure.
US08501543B1	Direct-write wafer level chip scale package A method and structure provides a Direct Write Wafer Level Chip Scale Package (DWWLCSP) that utilizes permanent layers/coatings and direct write techniques to pattern these layers/coatings, thereby avoiding the use of photoimagable materials and photo-etching processes.
US08501542B2	Double-faced electrode package, and its manufacturing method A dual-face package has an LSI chip sealed with a mold resin, and electrodes for external connections on both of the front face and the back face. The LSI chip is bonded onto the die pad of a leadframe whose outer lead portions are exposed as back-face electrodes at at least the back face. The LSI chip and a plurality of inner lead portions of the leadframe are connected by wiring. At least some of the plurality of inner lead portions have front-face electrodes integrally formed by working a portion of the leadframe. Head faces of the front-face electrodes, or bump electrodes connected to the respective head faces of the front-face electrodes serve as electrodes for external connections to another substrate, element, or the like.
US08501541B2	Semiconductor device and method of conforming conductive vias between insulating layers in saw streets A semiconductor device is made by disposing a plurality of semiconductor die on a carrier and creating a gap between each of the semiconductor die. A first insulating material is deposited in the gap. A portion of the first insulating material is removed. A conductive layer is formed over the semiconductor die. A conductive lining is conformally formed on the remaining portion of the first insulating material to form conductive via within the gap. The conductive vias can be tapered or vertical. The conductive via is electrically connected to a contact pad on the semiconductor die. A second insulating material is deposited in the gap over the conductive lining. A portion of the conductive via may extend outside the first and second insulating materials. The semiconductor die are singulated through the gap. The semiconductor die can be stacked and interconnected through the conductive vias.
US08501539B2	Semiconductor device package A method for forming a semiconductor device package includes providing a lead frame array having a plurality of leads. Each of the plurality of leads includes an opening extending through the lead from a first surface of the lead to a second surface of the lead, opposite the first surface, and each of the openings is at least partially filled with a solder wettable material. A plurality of semiconductor devices are attached to the lead frame array. The plurality of semiconductor devices are encapsulated, and, after encapsulating, the plurality of semiconductor devices are separated along separation lines which intersect the openings.
US08501537B2	Methods for bonding semiconductor structures involving annealing processes, and bonded semiconductor structures formed using such methods Methods of bonding together semiconductor structures include annealing a first metal feature on a first semiconductor structure, bonding the first metal feature to a second metal feature of a second semiconductor structure to form a bonded metal structure that comprises the first metal feature and the second metal feature, and annealing the bonded metal structure. Annealing the first metal feature may comprise subjecting the first metal feature to a pre-bonding thermal budget, and annealing the bonded metal structure may comprise subjecting the bonded metal structure to a post-bonding thermal budget that is less than the pre-bonding thermal budget. Bonded semiconductor structures are fabricated using such methods.
US08501532B2	Method of fabricating organic light emitting diode display An organic light emitting diode display and a fabrication method thereof, the display including a substrate; a thin film transistor on the substrate; and an organic light emitting diode on the substrate, the organic light emitting diode including a pixel electrode, an organic emission layer, and a common electrode, wherein the organic emission layer includes a red (R) pixel, a green (G) pixel, and a blue (B) pixel, the pixel electrode includes a first pixel electrode, a second pixel electrode, and a third pixel electrode that respectively correspond to the red pixel, the green pixel, and the blue pixel, the first pixel electrode, the second pixel electrode, and the third pixel electrode each have different thicknesses, and the first pixel electrode, the second pixel electrode, and the third pixel electrode each include a first hydrophobic layer.
US08501528B2	Radiofrequency plasma reactor and method for manufacturing vacuum process treated substrates An electrode (3i) of a radiofrequency parallel plate plasma reactor includes an electrode surface of a multitude of surfaces of metal members (28) which reside on dielectric spacing members (29), whereby the metal members (28) are mounted in an electrically floating manner. The dielectric members (29) are mounted, opposite to the metal members (28), upon a metal Rf supply body (14a).
US08501527B2	Deposition chamber cleaning system and method An in-situ method of cleaning a vacuum deposition chamber can include flowing at least one reactive gas into the chamber.
US08501525B2	Method of fabrication of programmable memory microelectric device A method of fabricating a programmable memory microelectronic device includes depositing onto a first electrode an intermediate layer of a material having a chalcogenide; depositing an ionizable metallic layer on the intermediate layer; irradiating with ultraviolet radiation the ionizable metallic layer so that metallic ions from the ionizable metallic layer diffuse into the intermediate layer to form a chalcogenide material containing metallic ions, and depositing a second electrode on the layer of chalcogenide material containing metallic ions obtained in the prior step. The second and third steps are repeated at least n times, where n is an integer greater than or equal to 1. The ionizable metallic layer deposited during the second step has a sufficiently small thickness that the metallic ions may be diffused totally during the irradiation (third) step.
US08501521B1	Copper species surface treatment of thin film photovoltaic cell and manufacturing method A method for forming a thin film photovoltaic device. The method includes providing a transparent substrate comprising a surface region. A first electrode layer is formed overlying the surface region. A copper layer is formed overlying the first electrode layer and an indium layer is formed overlying the copper layer to form a multi-layered structure. The method subjects at least the multi-layered structure to a thermal treatment process in an environment containing a sulfur bearing species to form a copper indium disulfide material and a thickness of substantially copper sulfide material. The thickness of the copper sulfide material is removed to expose a surface region having a copper poor surface comprising a copper to indium atomic ratio of less than about 0.95:1. The method subjects the copper poor surface to a copper species to convert the copper poor surface from an n-type semiconductor characteristic to a p-type semiconductor characteristic. A window layer is formed overlying the copper indium disulfide material.
US08501519B2	Method of production of CIS-based thin film solar cell A method of production of a CIS-based thin film solar cell comprises the steps of forming an alkali control layer on a high strain point glass substrate, forming a back surface electrode layer on the alkali control layer, forming a CIS-based light absorption layer on the back surface electrode layer, and forming an n-type transparent conductive film on the CIS-based light absorption layer, wherein the alkali control layer is formed to a thickness which allows heat diffusion of the alkali metal which is contained in the high strain point glass substrate to the CIS-based light absorption layer and, furthermore, the CIS-based light absorption layer has an alkali metal added to it from the outside in addition to heat diffusion from the high strain point glass substrate.
US08501517B1	Method of assembling pressure sensor device A method of assembling a pressure sensor device includes providing a substrate having a plurality of substrate connection pads. A pressure sensor die is attached to a first major surface of the substrate and bond pads of the pressure sensor die are electrically connected to the respective substrate connection pads. A retractable cavity pin is placed on the first major surface of the substrate such that the cavity pin covers the pressure sensor die and the electrical connections to the die. A molding compound is then dispensed onto the first major surface of the substrate such that the molding compound surrounds the pressure sensor die and the cavity pin. The cavity pin is retracted such that a cavity is formed around the pressure sensor die and a gel material is dispensed within the cavity such that the gel material fills the cavity and covers the pressure sensor die.
US08501513B2	Optoelectronic semiconductor component with current spreading layer An optoelectronic semiconductor component comprising a semiconductor body (10) and a current spreading layer (3) is specified. The current spreading layer (3) is applied to the semiconductor body (10) at least in places. In this case, the current spreading layer (3) contains a metal (1) that forms a transparent electrically conductive metal oxide (2) in the current spreading layer, and the concentration (x) of the metal (1) decreases from that side of the current spreading layer (3) which faces the semiconductor body (10) toward that side of said current spreading layer which is remote from the semiconductor body (10). A method for producing such a semiconductor component is also disclosed.
US08501510B2	Optoelectronic component with three-dimension quantum well structure and method for producing the same An optoelectronic component with three-dimension quantum well structure and a method for producing the same are provided, wherein the optoelectronic component comprises a substrate, a first semiconductor layer, a transition layer, and a quantum well structure. The first semiconductor layer is disposed on the substrate. The transition layer is grown on the first semiconductor layer, contains a first nitride compound semiconductor material, and has at least a texture, wherein the texture has at least a first protrusion with at least an inclined facet, at least a first trench with at least an inclined facet and at least a shoulder facet connected between the inclined facets. The quantum well structure is grown on the texture and shaped by the protrusion, the trench and the shoulder facet.
US08501506B2	Method for manufacturing light emitting diode An LED includes a substrate, a first n-type GaN layer, a connecting layer, a second n-type GaN layer, a light emitting layer, and a p-type GaN layer formed on the substrate in sequence, the connecting layer being etchable by alkaline solution, a bottom surface of the second n-type GaN layer facing towards the connecting layer having a roughened exposed portion, the GaN on the bottom surface of the second n-type GaN layer having an N-face polarity, a blind hole extending through the p-type GaN layer, the light emitting layer and the second n-type GaN layer to expose the connecting layer, and an annular rough portion formed on the bottom surface of the second n-type GaN layer and surrounding each blind hole.
US08501500B2	Method for monitoring the removal of polysilicon pseudo gates The present invention discloses a method for monitoring the removal of a polycrystalline silicon dummy gate, comprising the steps of: forming a polycrystalline silicon dummy gate structure on a surface of a wafer; determining a measurement target and an error range of mass of the wafer; and measuring the mass of the wafer by a mass measurement tool after polycrystalline silicon dummy gate removal to determine whether the polycrystalline silicon dummy gate has been completely removed. According to the measurement method of the present invention, the full wafer may be quickly and accurately measured without requiring a specific test structure, to effectively monitor and determine whether the polysilicon dummy gate is thoroughly removed, meanwhile said measurement method gives feedback directly, quickly and accurately without causing any damage to the wafer.
US08501497B2	Forming sample combinations using liquid bridge systems The present invention generally relates to methods of constructing liquid bridges and methods of forming predetermined combinations of samples using liquid bridges.
US08501491B2	Method of measuring concentration of fuel A method of measuring concentration of a fuel is provided. First, a fuel cell unit having at least an anode, a cathode, and a membrane electrode assembly (MEA) is provided. Next, a fuel is supplied to the anode, while a reactive gas is supplied to the cathode. Then, the amount of the reactive gas supplied to the cathode is adjusted and the concentration of the fuel is estimated in accordance with the consumption rate of the reactive gas in the fuel cell unit, wherein a method of estimating the concentration of the fuel in accordance with a consumption rate of the reactive gas in the cathode includes measuring a concentration of the reactive gas supplied to the cathode and estimating the concentration of the fuel in accordance with a relationship between the concentration of the reactive gas supplied to the cathode and time.
US08501490B2	Bioassays based on polymeric sequence probe Polymeric sequence probes and methods are described that enhance the speed and sensitivity of detection of target analytes by combining a multiplicity of binding moieties specific for analyte, at least two of which are linearly arranged and optionally a multiplicity of detectable labels.
US08501488B2	Compound for derivatizing polypeptides and method for sequencing and quantifying amino acids in polypeptides using the same The present invention relates to a compound for N-terminal substitution of polypeptides which is used in sequencing and quantifying amino acids and a method for sequencing and quantifying an amino acid sequence using the same. The method for sequencing and quantifying amino acids in accordance with the present invention leads to a relative quantitative analysis of proteins with very high reliability, and can distinctively discriminate between y-type ions and b-type ions on the MS/MS spectra, providing the means for realization of high-reliability protein identification.
US08501487B2	Composition for use as a peptide retention standard and a method of predicting peptide hydrophobicity in liquid chromatography A composition comprising synthetic peptides for use as a peptide retention standard in liquid chromatography applications is disclosed Said synthetic peptides have a broad range of hydrophobicity while maintaining low variation in their molecular weights The synthetic peptides disclosed consist of the ammo acid sequences LGGGGGGDGSR, LGGGGGGDFR, LLGGGGDFG, LLLGGDFR, LLLLDFR, LLLLLDFR A method of predicting the hydrophobicity of an unknown peptide in liquid chromatography using a composition of peptide retention standards and a method of developing a Universal Hydrophobicity Index (UHI) for the measurement of peptide hydrophobicity in liquid chromatography are also described.
US08501482B2	Apparatus for analyzing particles in urine and method thereof An apparatus, intended for use in analyzing particles in urine is disclosed, that comprising: a sample distribution section for distributing urine samples to a first aliquot and a second aliquot; a first specimen preparing section for preparing a first specimen for measuring urinary particles, containing at least erythrocytes, by mixing a first stain reagent and the first aliquot; a second specimen preparing section for preparing a second specimen for measuring bacteria by mixing a second stain reagent and the second aliquot; and an optical detecting section comprising a light source for irradiating a light to a specimen being supplied, a scattered light receiving element for detecting scattered light emitted from the specimen, and a fluorescence receiving element for detecting fluorescence emitted from the specimen. A method intended for use in analyzing particles in urine is also disclosed.
US08501475B2	Systems and methods for contaminant removal from a microalgae culture Systems and methods for the removal of contaminants from a liquid culture microalgae and/or cyanobacteria comprise an let tube, a pump, a gas injector, a vertical chamber, and/or a collection container that promotes the production of foam in the microalgae culture, wherein the foam contains the contaminants.
US08501469B2	Cells useful for immuno-based botulinum toxin serotype A activity assays The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.
US08501461B2	System for performing multi-formatted assays An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.
US08501456B2	Method for making lactic acid bacteria composition A method for making at least 2 kg (dry weight) of a lactic acid bacteria composition formulated with from 1% to 50% of ascorbate or ascorbic acid (w/w−dry matter) as antioxidant, wherein the pH is controlled so 3≦pH≦8 during at least the majority of the fermentation process by addition of a base not comprising NH3 (ammonia).
US08501445B2	Method for producing oligomer and/or monomer by degrading biodegradable resin An object of the present invention is to provide a method for efficiently producing an oligomer or a monomer by degrading a biodegradable resin using an enzyme, so that the oligomer or the monomer can be recovered.The present invention provides a method for producing an oligomer and/or a monomer by degrading a biodegradable resin in a degradation liquid containing a biodegradation enzyme, a buffer agent, an organic solvent, and water. In this method, the SP value of the organic solvent is less than 8.5 or more than 11.5, and the percentage content of the organic solvent (by volume) in the degradation liquid is higher than 1% and lower than 15%. In the method for producing an oligomer or a monomer, the degradation percentage of the biodegradable resin is low, and deposits of aggregates of the oligomer and/or the monomer are few, so that the recovery percentage is high.
US08501444B2	Fermentation process for higher yield coefficient of lipase-inhibitor with respect to consumed fatty acid The invention provides a process for the production of lipase inhibitors via an improvised fermentation process characterized in that a combinatorial feeding of linoleic acid or its esters or salts thereof and an omega-9 fatty acid, preferably oleic acid and/or its derivatives is employed during said process resulting in an improved yield co-efficient, productivity further providing ease of operation.
US08501443B2	Haplotype analysis The present invention provides an efficient way for high throughput haplotype analysis. Several polymorphic nucleic acid markers, such as SNPs, can be simultaneously and reliably determined through multiplex PCR of single nucleic acid molecules in several parallel single molecule dilutions and the consequent statistical analysis of the results from these parallel single molecule multiplex PCR reactions results in reliable determination of haplotypes present in the subject. The nucleic acid markers can be of any distance to each other on the chromosome. In addition, an approach wherein overlapping DNA markers are analyzed can be used to link smaller haplotypes into larger haplotypes. Consequently, the invention provides a powerful new tool for diagnostic haplotyping and identifying novel haplotypes.
US08501442B2	Determination of 5-ASA efficacy in CRC prevention and/or treatment by gene expression analysis A method is disclosed for the determination of 5-ASA efficacy in preventing and/or treating CRC in a mammalian, which comprises the analysis of the inhibition of the β-catenin pathway in presence of 5-ASA. More in details, the method comprises measuring the expression of at least one gene involved in the regulation of the β-catenin signalling pathway, such as μ-protocadherin, E-cadherin, β-catenin, Axin1, ICAT, p21waf−1 and the expression of onco-suppressor genes, such as KLF4 and CEBPα. Gene expression can be measured in accordance to the methods commonly available in the art such as QRT-PCR and immunohistochemistry.
US08501441B2	Target amplification and sequencing with primers comprising triplex forming monomer units The current inventors have discovered that the incorporation of a triplex forming monomer unit into oligonucleotides surprisingly gives the oligonucleotide a number of favorable characteristics. The oligonucleotides are advantageous because they allow modulation of the melting temperature of an oligonucleotide, they have improved sequence specificity and they can form triplexes by Hoogsteen or reverse Hoogsteen base pairing with double stranded nucleic acids. Moreover, some of the oligonucleotides of the invention have useful fluorescent characteristics, and the oligonucleotides comprising a triplex forming monomer can be used as substrates for enzymatic manipulations such as primer extension.
US08501436B2	Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester Disclosed is a method for the preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester, comprising the asymmetric reduction of arylketone and the carbamation of alcohol.
US08501431B2	Method for screening for compounds selectively interacting with RAD9 Natural and synthetic compounds of Formulae Ia-Ie having a lactone structure, in particular Securolide, have been determined to be effective anti-tumor compounds which target the hrad9 gene and/or protein encoded thereby or complex containing the protein and/or the p53 gene and/or protein. Securolide is cytoselective for mutants of hRad9 based on studies conducted in Rad9 mutant yeast strains. Securolide appears to interact with mutant hRad9 in cancer cells to produce DNA lesions which result in apoptosis. Studies have demonstrated that Securolide is useful for treating proliferation disorders such as melanoma, leukemia, breast cancer, lung cancer, ovarian cancer, colon cancer, esophagus cancer, liver cancer, and lymphatic cancer, and to alleviate pain associated with the cancer. Other compounds effective for the treatment of cancer and optionally pain associated therewith may also be identified using the same assays, for example, by screening for efficacy in assays using Rad9 and/or p53 defective mutant yeasts.
US08501429B2	Method for quantitatively analyzing an anticoagulant in a sample A method for quantitatively analyzing an anticoagulant in a sample may include: (a) providing and incubating a reaction mixture comprising (i) the sample, (ii) a defined amount of an activated coagulation factor whose activity is directly or indirectly influenceable by the anticoagulant to be determined, wherein the activated coagulation factor is present in a separate reagent which is added to the reaction mixture, (iii) a cleavable substrate which has at least one cleavage site for the activated coagulation factor, and (iv) a solid phase to which the cleavable substrate is bound or becomes bound during the incubation; (b) separating the solid phase; and (c) determining the amount of solid-phase-bound, uncleaved substrate, wherein the determined amount of the solid-phase-bound uncleaved substrate is proportional to an amount or activity of the anticoagulant in the sample.
US08501420B2	Biomarkers for prediction of major adverse cardiac events and uses thereof The present invention relates to combinations of biomarkers and levels thereof that may be used, for example, in the determination of risk associated with the occurrence of a major adverse cardiac event (MACE) in a patient.
US08501418B2	Method of treating renal dysfunction based on perlecan as a biomarker The application discloses PERLECAN as a new biomarker for renal dysfunction; methods for predicting, diagnosing, prognosticating and/or monitoring said dysfunction based on measuring said biomarker; and kits and devices for measuring said biomarker and/or performing said methods.
US08501414B2	Detection of bacteria The invention relates to a method for detecting bacterial contaminations preferably in physiological samples as well as sequences of synthetic oligonucleotides used therefor. The method comprises the steps of i) extracting the nucleic acid, particularly bacterial DNA, ii) amplification by means of primers and detection by means of oligonucleotides, particularly fluorescence-marked oligonucleotides as hybridization probes, containing a sequence that is selected from among a group encompassing SEQ ID NO:5 to SEQ ID NO:35, preferably in real-time PCR, and iii) evaluation by means of fusion curve analysis.
US08501411B2	Herbicide tolerant cotton plants and methods for identifying same The invention provides specific transgenic cotton plants, plant material and seeds, characterized in that these products harbor a specific transformation event at a specific location in the cotton genome. Tools are also provided which allow rapid and unequivocal identification of the event in biological samples.
US08501407B2	Soybean transgenic event MON 87708 and methods of use thereof The invention provides a transgenic soybean event MON 87708 plant and plants, plant cells, seeds, plant parts, and commodity products derived from event MON 87708. The invention also provides polynucleotides specific for event MON 87708 and plants, plant cells, seeds, plant parts, and commodity products comprising polynucleotides specific for event MON 87708. The invention also provides methods related to event MON 87708.
US08501405B2	Real-time sequencing methods and systems The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to either enhance or inhibit such reactions. In certain preferred embodiments, RNA templates are used in single-molecule real-time sequencing reactions.
US08501403B2	Amplification of DNA fragments A method for detecting a nucleic acid molecule having a target sequence adjacent a 3′ terminus is provided. Also provided is a method for differentiating nucleic acid molecules having a target sequence adjacent a 3′ terminus from nucleic acid molecules in which the same sequence is embedded within the molecule.
US08501402B2	Methods and devices for producing biomolecules A scalable process and device for producing a biomolecule, in particular pharmaceutical grade plasmid DNA. The process includes the steps of alkaline lysis and a neutralization. For separating the lysate and the precipitate, the mixture is allowed to gently flow downward through a clarification reactor that is partially filled, in its lower part, with retention material like glass beads, whereby the precipitate is retained on top of and within the retention. In a preferred embodiment of the lysis step, cell suspension and alkaline lysis solution flow through a lysis reactor that is filled with particulate material like glass beads. The process can be run continuously and fully automated.
US08501399B2	Asymmetrically branched polymer conjugates and microarray assays A method of detection comprising a conjugate of a randomly and asymmetrically branched dendritic polymer.
US08501398B2	Luminescence assay using macrocyclic lanthanide (III) complexes The invention provides a method of determining the amount of an analyte having an oxidation potential, for a one electron oxidation process, of about +0.10 to about +1.20 volts at pH 7, relative to the normal hydrogen electrode at 298K, said method comprising measuring the emission intensity or emission lifetime, at two or more wavelengths, from a sample comprising said analyte and two or more different macrocyclic lanthanide (III) complexes, wherein each of said macrocyclic lanthanide (III) complexes comprises a different lanthanide ion but the same macrocyclic ligand, and using a ratio of emission intensities or emission lifetimes measured at two different wavelengths to calculate the amount of analyte in said sample.
US08501397B2	Enrichment of stem cells from adult tissues Subjecting a heterogeneous cell population (one with both stem cells and non-stem cells) to extreme stress selectively eliminated the non-stem cells and resulted in the enrichment of stem cells in the population. The stress can take many forms, including without limitation, cell toxins, high temperature, high salt, and low oxygen (hypoxic) conditions. The number of stem cells remaining after stress were increased, and showed increased expression of traditional stem cell markers. The stem cells were shown to be capable of proliferation and differentiation into multiple types of cells. This method allows purification of stem cells from adult heterogeneous cell populations on a large scale basis without requirement of expensive equipment, and without requiring the presence of cell surface markers. Stem cells produced by the above method can be used for clinical applications, including tissue engineering.
US08501396B2	Dermal micro-organs, methods and apparatuses for producing and using the same Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for producing the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived, having dimensions selected so as to allow passive diffusion of adequate nutrients and gases to cells of the DMO and diffusion of cellular waste out of the cells. Some embodiments of the invention provide methods and apparatuses for harvesting the DMO. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin-related tissue structure.
US08501391B2	Photosensitive resin composition, flexographic printing plate, and method for producing flexographic printing plate The present invention provides a photosensitive resin composition comprising 100 parts by mass of a polyurethane prepolymer having an ethylenically unsaturated group, 10 to 150 parts by mass of an ethylenically unsaturated compound, and 0.01 to 10 parts by mass of a photopolymerization initiator, wherein the ethylenically unsaturated compound comprises 0.1 to 10 parts by mass of a polyfunctional ethylenically unsaturated compound having 6 or more (meth)acryloyl groups in a molecule thereof with respect to 100 parts by mass of the polyurethane prepolymer.
US08501390B2	Laser engravable flexographic printing articles based on millable polyurethanes, and method A flexographic printing sleeve or plate is made by a method that includes providing a millable polyurethane, crosslinking the millable polyurethane, and forming a relief by at least laser engraving the crosslinked millable polyurethane. For example, crosslinking may be accomplished by a peroxide-based process or by a vulcanization process using sulfur. A relief in one example is formed by extruding the millable polyurethane, thermally crosslinking the polyurethane after the extrusion step and laser engraving the crosslinked millable polyurethane. A printing article is formed into the shape of a flat printing plate or a continuous in-the-round printing sleeve.
US08501388B2	Method of making laser-ablatable elements A method is used to make a laser-ablatable element for direct laser engraving that has a laser-ablatable, relief-forming layer that has a relief-image forming surface and a bottom surface. The relief-forming layer can be prepared by applying multiple formulations. Each formulation comprises a coating solvent, a laser-ablatable polymeric binder, and an infrared radiation absorbing compound. The infrared radiation absorbing compound concentration in the resulting sub-layers is different in each adjacent pair of sub-layers so that the concentration is always greater in each pair sub-layer that is closer to the substrate, and the concentration is progressively greater in the sub-layers as they are closer to the substrate after the coating solvent is removed, wherein the multiple sub-layers provide a relief-forming layer so that the sub-layer farthest from the substrate provides a relief-image forming surface.
US08501387B2	Resist composition for immersion exposure, method of forming resist pattern using the same, and fluorine-containing compound A resist composition for immersion exposure, including a base component that exhibits changed solubility in an alkali developing solution under action of acid, an acid generator component that generates acid upon exposure, and a fluorine-containing compound represented by a general formula (c-1) that is decomposable in an alkali developing solution: wherein R1 represents an organic group which may contain a polymerizable group, with the proviso that said polymerizable group has a carbon-carbon multiple bond, and the carbon atoms forming the multiple bond are not directly bonded to the carbon atom within the —C(═O)— group in general formula (c-1); and R2 represents an organic group having a fluorine atom.
US08501385B2	Positive-type radiation-sensitive composition, and resist pattern formation method A positive-tone radiation-sensitive composition is used in a resist pattern-forming method as a first positive-tone radiation-sensitive composition. A positive-tone radiation-sensitive composition includes a polymer, a photoacid generator, and a solvent. The polymer includes an acid-labile group and a crosslinkable group. The resist pattern-forming method includes providing the first positive-tone radiation-sensitive composition on a substrate to form a first resist pattern on the substrate. The first resist pattern is made to be inactive to light or heat so that the first resist pattern is insoluble in a second positive-tone radiation-sensitive composition. The second positive-tone radiation-sensitive composition is provided on the substrate to form a second resist pattern on the substrate on which the first resist pattern is formed.
US08501384B2	Positive resist composition and patterning process A positive resist composition comprising a polymer having a tetrahydrobenzocycloheptane-substituted secondary or tertiary carboxyl group ester as an acid labile group exhibits a high contrast of alkaline dissolution rate before and after exposure, a high resolution, a good pattern profile and minimal edge roughness after exposure, a significant effect of suppressing acid diffusion rate, and improved etching resistance.
US08501383B2	Coating compositions for use with an overcoated photoresist Cyanurate compositions are provided that are particularly useful as a reagent to form a resin component of a coating composition underlying an overcoated photoresist. Preferred isocyanurates compound comprise substitution of multiple cyanurate nitrogen ring atoms by at least two distinct carboxy and/or carboxy ester groups.
US08501381B2	Liquid developer composition and method of its preparation The invention relates to a liquid developer composition comprising a dispersant, and toner particles dispersed in said dispersant. The liquid developer composition can be used for printing onto a substrate. The binder resin in the toner particles is curable, e.g. by UV-light.
US08501380B2	Electrostatic latent image developing toner, electrostatic latent image developer, toner cartridge, process cartridge and image forming apparatus An electrostatic latent image developing toner includes a mother particle which contains a coloring agent, a release agent and a binder resin; and an inorganic particle which is added to the surface of the mother particle, and wherein a relation between a relaxation time t and a relaxation modulus G(t) which are determined from the dynamic viscoelasticity measurement made on the toner satisfies the following equations (1) and (2); G(t1)<100 Pa (1) 515<(G(t2)−G(t1))/(log(t1)−log(t2))<1,230 (2) wherein t1 represents the maximum relaxation time and t2 represents the minimum relaxation time.
US08501379B2	Toner and method for producing the same and developer A toner containing base particles produced by dissolving and/or dispersing a toner material in an organic solvent so as to prepare a toner material solution, and emulsifying and/or dispersing the toner material solution in an aqueous medium, wherein the toner material contains a binder resin and a releasing agent, the binder resin contains a polyester resin, and the releasing agent is a hydrocarbon wax which is modified with a carboxylic acid or carboxylic anhydride.
US08501378B2	Electrophotographic toner and method of preparing the same An electrophotographic toner includes a latex, a colorant, and a release agent, wherein G′(80) is in a range of about 2.0×105 Pa to about 3.0×106 Pa and G′(80)/G′(140) is in a range of about 2.0×102 to about 3.0×103, wherein in regard to a molecular weight distribution on a gel permeation chromatography (GPC) chromatogram, the molecular weight region of 1.0×104 g/mol or less of a tetrahydrofuran (THF)-soluble component of the electrophotographic toner is about 5% or less, and the molecular weight region of 1.0×105 g/mol or more of the THF-soluble component of the electrophotographic toner is in a range of about 5% to about 20%, where G′(80) and G′(140) respectively denote storage moduli of the electrophotographic toner at temperatures of 80° C. and 140° C. when a dynamic viscoelasticity according to a sine-wave vibration is measured at an angular velocity of 6.28 rad/sec and at a temperature increase rate of 2.0° C./min.
US08501377B2	Magnetic toner Provided is a magnetic toner capable of providing a stable image by suppressing sleeve contamination even under a high-temperature and high-humidity environment and under a normal-temperature and low-humidity environment and further suppressing large-particle fogging caused after the toner is left alone for a week. The magnetic toner contains toner particles, each of which contains a binder resin and a magnetic iron oxide particle, in which the binder resin has a polyester unit, the toner has i) a dielectric loss factor at 40° C. and 100 kHz of 0.50 pF/m or more but 0.90 pF/m or less, and ii) a true specific gravity of 1.50 g/cm3 or more but 1.85 g/cm3 or less.
US08501376B2	System and method for test pattern for lithography process A method for performing a photolithography process includes providing a reticle on a projection apparatus, the reticle having a test pattern defined thereon, the test pattern including a plurality of one-dimensional structures and a plurality of two-dimensional structures. The test pattern defined on the reticle is transferred to at least one area on a wafer. The projection apparatus is focused on the test pattern transferred on the wafer during a photolithography process to perform a process monitoring.
US08501373B2	Passivation of multi-layer mirror for extreme ultraviolet lithography A reflector structure suitable for extreme ultraviolet lithography (EUVL) is provided. The structure comprises a substrate having a multi-layer reflector. A capping layer is formed over the multi-layer reflector to prevent oxidation. In an embodiment, the capping layer is formed of an inert oxide, such as Al2O3, HfO2, ZrO2, Ta2O5, Y2O3-stabilized ZrO2, or the like. The capping layer may be formed by reactive sputtering in an oxygen environment, by non-reactive sputtering wherein the materials are sputtered directly from the respective oxide targets, by non-reactive sputtering of the metallic layer followed by full or partial oxidation (e.g., by natural oxidation, by oxidation in oxygen-containing plasmas, by oxidation in ozone (O3), or the like), by atomic level deposition (e.g., ALCVD), or the like.
US08501370B2	Binder for electrode of fuel cell, electrode for fuel cell including the binder, method of manufacturing the electrode, and fuel cell using the electrode A binder for an electrode of a fuel cell is a basic polymer including a nitrogen-containing functional group and a proton conductive polymer having a phosphoric acid impregnation capacity of 200 wt % or less. An electrode for a fuel cell includes the binder and a catalyst, and a fuel cell includes the electrode. The electrode is manufactured by mixing the binder, a catalyst, and a solvent; and coating the mixture on a carbon support and heat-treating the coated mixture. The binder has excellent proton conductivity by having a phosphoric acid impregnation capacity of 200 wt % or less, and has improved durability without membrane damage and micro-structural changes due to swelling, which occurs when PBI is used as a binder. Accordingly, an electrode including the binder has improved phosphoric acid retention capacity, and increased wetting velocity. Thus, a fuel cell having improved efficiency can be manufactured due to the improved proton conductivity and durability of the electrode.
US08501366B1	Nanoengineered membrane electrode assembly interface A membrane electrode structure suitable for use in a membrane electrode assembly (MEA) that comprises membrane-affixed metal nanoparticles whose formation is controlled by a photochemical process that controls deposition of the metal nanoparticles using a photocatalyst integrated with a polymer electrolyte membrane, such as an ionomer membrane. Impregnation of the polymer membrane with the photocatalyst prior to metal deposition greatly reduces the required amount of metal precursor in the deposition reaction solution by restricting metal reduction substantially to the formation of metal nanoparticles affixed on or near the surface of the polymer membrane with minimal formation of metallic particles not directly associated with the membrane.
US08501365B2	Solid electrolyte fuel cell stack A solid electrolyte fuel cell comprises a solid electrolyte body having a fuel electrode contacting a fuel gas and an air electrode contacting air. A plurality of the solid electrolyte fuel cells are stacked to form a solid electrolyte fuel cell stack, in which the stacked body of the solid electrolyte fuel cells is pressed in the stacked direction and fixed by a fixing member inserted into a through-hole passing through the stacked body in the stacked direction. Inside the through-hole, there is equipped an inner gas channel for supplying the gas to the solid electrolyte fuel cell side or evacuating the gas from the solid electrolyte fuel cell side.
US08501364B2	Fuel cell bipolar plate exit for improved flow distribution and freeze compatibility A fuel cell assembly is disclosed that utilizes a water transport structure extending from fuel cell plates of the assembly into fuel cell assembly manifolds, wherein the water transport structure facilitates the transport of liquid water from the fuel cell plates thereby minimizing the accumulation of liquid water and ice in the fuel cell stack.
US08501358B2	Solid oxide fuel cell device The present invention is a solid oxide fuel cell device (1), having a fuel cell module (2) furnished with a plurality of fuel cell units (16); fuel supply means (38) for supplying fuel; generating oxidant gas supply means (45) for supplying oxidant gas for generation; combustion section placed at one end portion of the solid oxide fuel cell units for combusting fuel; and control means for controlling the fuel supply means and generating oxidant gas supply means, and executing the startup mode operation for raising the solid oxide fuel cell units to a predetermined temperature, as well as the generating mode operation for outputting electrical power; whereby during the startup mode operation, the control means generates a weak power smaller than the generation startup power, raising the temperature of the solid oxide fuel cell units by the heat of generation.
US08501353B2	Negative electrode active material, negative electrode, and power storage device An object is to improve characteristics of a power storage device and achieve a long lifetime. In the case where a lithium nitride is used for a negative electrode active material of a power storage device, a plurality of lithium nitride layers with different lithium concentrations are stacked. For example, in the case where a first lithium nitride layer and a second lithium nitride layer are stacked over a current collector, lithium is contained in the first lithium nitride layer at a lower concentration than lithium contained in the second lithium nitride layer. In this case, a concentration of a transition metal of the first lithium nitride layer is higher than a concentration of the transition metal of the second lithium nitride layer. Note that another alkali metal may be used instead of lithium.
US08501352B2	Lithium-metal-oxide composite electrodes A composite material having: particles of a first lithium-metal oxide compound, particles of a conductive second lithium-metal oxide compound, a conductive matrix, and a polymeric binder.
US08501350B2	Lithium manganese composite oxide To provide a lithium manganese composite oxide capable of improving the initial discharge capacity of secondary batteries by removing more Li ions than the conventional lithium manganese composite oxide does when used in the positive electrode used for secondary batteries. A lithium manganese composite oxide having a Li2MnO3 type crystal structure, wherein a part of Li and/or Mn in a lithium manganese oxide represented by a formula Li2MnO3 is substituted by one or more doping elements M selected from the group consisting of Ti, Zr, Hf, V, Nb, Ta, Si, Ge, Sn, P, Sb and Bi. The above-described lithium manganese composite oxide, wherein the doping elements are P and/or Si. A positive electrode used for nonaqueous electrolyte secondary batteries, comprising the above-described lithium manganese composite oxide. A nonaqueous electrolyte secondary battery comprising the above-described positive electrode used for nonaqueous electrolyte secondary batteries.
US08501349B2	Hydrogen-based electrochemical energy storage An energy storage device (100) providing high storage densities via hydrogen storage. The device (100) includes a counter electrode (110), a storage electrode (130), and an ion conducting membrane (120) positioned between the counter electrode (110) and the storage electrode (130). The counter electrode (110) is formed of one or more materials with an affinity for hydrogen and includes an exchange matrix for elements/materials selected from the non-noble materials that have an affinity for hydrogen. The storage electrode (130) is loaded with hydrogen such as atomic or mono-hydrogen that is adsorbed by a hydrogen storage material such that the hydrogen (132, 134) may be stored with low chemical bonding. The hydrogen storage material is typically formed of a lightweight material such as carbon or boron with a network of passage-ways or intercalants for storing and conducting mono-hydrogen, protons, or the like. The hydrogen storage material may store at least ten percent by weight hydrogen (132, 134) at ambient temperature and pressure.
US08501348B2	Submicron-scale and lower-micron graphitic fibrils as an anode active material for a lithium ion battery The present invention provides a lithium ion battery anode material comprising a submicron-scaled graphitic fibril having a diameter or thickness less than 1 μm but greater than 100 nm, wherein the fibril is obtained by splitting a micron-scaled carbon fiber or graphite fiber along the fiber axis direction. This type of graphitic fibril exhibits exceptionally high electrical conductivity, thermal conductivity, elastic modulus, and strength. The anode material exhibits a high reversible capacity and good charge/discharge cycling stability for both low and high charge rate conditions. Another preferred embodiment of the present invention is an anode active material containing a graphitic fibril with a diameter greater than 1 μm but less than 6 μm obtained by splitting a carbon fiber or graphite fiber of at least 6 μm in diameter.
US08501345B2	Battery cell design with asymmetrical terminals An electrochemical cell is provided. The cell includes a plurality of electrode sheets separated by at least one separator sheet. A positive extension tab is attached to a current collecting tabs of positive electrode sheets, and a negative extension tab is attached to current collecting tabs of the negative electrode sheets. The dimensions of the positive extension tab and the negative extension tab are selected such that temperature difference between positive extension tab and the negative extension tab are minimized when the electrochemical cell is in use.
US08501342B2	Rechargeable battery with an antenna assembly A rechargeable battery is provided including a bare cell having a can. The can has an electrode assembly. The electrode assembly has an electrode terminal withdrawn from one surface of the bare cell. A circuit is electrically coupled to the bare cell. The circuit includes a charge-discharge circuit and an antenna circuit. A case is connected to the electrode terminal for receiving and covering the circuit. An antenna assembly is on an outer surface of the bare cell. The antenna assembly includes a line antenna for receiving a radio frequency signal. The line antenna is coupled to the antenna circuit.
US08501338B1	Method of controlled delivery for use in electrochemical power sources A system and method for improving electrochemical power sources through the dispensing encapsulation and dispersion into galvanic chambers of an electrochemical cell. Features of the method include the optimization of the concentration levels of chemicals involved in desired energy producing reactions.
US08501336B2	Battery box and electronic device using the same A battery box includes at least one battery and a switch apparatus. The switch apparatus includes a first conductor, a second conductor, and an operation element. The first conductor includes a first conductive portion and a first contact portion protruding from the first conductive portion. The second conductor includes a second conductive portion and a second contact portion protruding from the second conductive portion. The operation element is movable with respect to the housing and able to resist the second conductive portion along with the movement of the operation element. When the operation element is moved to resist the second conductive portion, the second contact portion contacts with the first contact portion, and when the operation element is moved to separate from the second conductive portion, the second contact portion does not contact with the first contact portion. An electronic device using the battery box is also provided.
US08501334B2	Rechargeable battery and method of injecting electrolyte thereinto Provided is a pouch-type rechargeable battery. A rechargeable battery according to an exemplary embodiment of the present invention includes: an electrode assembly including a positive electrode, a negative electrode, and a separator interposed between the positive electrode and the negative electrode; a case receiving the electrode assembly; an electrolyte solution injection member positioned at one side of the case and forming an injection hole; and a sealing member covering and sealing the injection hole.
US08501331B2	Binder composition for magnetic recording medium and magnetic recording medium A binder composition for a magnetic recording medium contains a vinyl copolymer having a structural unit of general formula [1]: wherein R1 is H, halogen, or methyl, L1 is a single bond or a divalent linking group, and Y is an alicyclic group; a structural unit of general formula [2]: wherein R2 is H, halogen, or methyl, L2 is a single bond or a divalent linking group, and Z is a hydrocarbon group with a carbon number of from 8 to 50; and a structural unit of general formula [3]: wherein R3 is H, halogen, or methyl, and L3 is a single bond or a divalent linking group.
US08501330B2	Perpendicular magnetic recording media with magnetic anisotropy gradient and local exchange coupling A perpendicular magnetic recording medium adapted for high recording density and high data recording rate comprises a non-magnetic substrate having at least one surface with a layer stack formed thereon, the layer stack including a perpendicular recording layer containing a plurality of columnar-shaped magnetic grains extending perpendicularly to the substrate surface for a length, with a first end distal the surface and a second end proximal the surface, wherein each of the magnetic grains has: (1) a gradient of perpendicular magnetic anisotropy field Hk extending along its length between the first end and second ends; and (2) predetermined local exchange coupling strengths along the length.
US08501328B2	Red phosphorescent compounds and organic electroluminescent devices using the same Disclosed herein are red phosphorescent compounds of the following one of Formulas 1 to 3 wherein Formula 1 R1 and R2 are independently a C1-C4 alkyl group, R3, R4, R5 and R6 are independently selected from hydrogen, C1-C4 alkyl groups and C1-C4 alkoxy groups, wherein Formula 2 R1, R2, R3 and R4 are independently selected from C1-C4 alkyl groups and C1-C4 alkoxy groups, wherein Formula 3 R1, R2, R3 and R4 are independently selected from hydrogen, C1-C4 alkyl groups and C1-C4 alkoxy groups, and wherein is selected from 2,4-pentanedione, 2,2,6,6,-tetramethylheptane-3,5-dione, 1,3-propanedione, 1,3-butanedione, 3,5-heptanedione, 1,1,1-trifluoro-2,4-pentanedione, 1,1,1,5,5,5-hexafluoro-2,4-pentanedione and 2,2-dimethyl-3,5-hexanedione.
US08501327B2	Aluminum alloy clad sheet for heat exchanger An aluminum alloy clad sheet for heat exchangers includes a core layer, a sacrificial layer disposed on one side of the core layer, and a brazing layer of an Al—Si alloy disposed on the other side of the core layer, wherein the core layer contains Si: 0.15% to 1.6% by mass, Mn: 0.3% to 2.0% by mass, Cu: 0.1% to 1.0% by mass, Ti: 0.02% to 0.30% by mass, and the remainder of Al and incidental impurities, and the sacrificial layer contains Zn: 4.0% to 10.0% by mass, Cr: 0.01% to 0.5% by mass, and the remainder of Al and incidental impurities.
US08501326B2	Wax replacement specialty formulated corrugating adhesive Adhesive compositions have properties that make them particularly well suited for recyclable corrugated boards for use in transporting and storing perishable foods such as fresh and frozen produce, seafood and meats together with ice, or under refrigeration.
US08501323B2	Two-component composition for producing polyurethane gel coats for epoxy-resin and vinyl-ester resin composite materials The invention relates to the use of a two-component composition comprising a polyol component and a polyisocyanate component, for producing polyurethane gel coats for epoxy-resin and vinyl-ester resin composite materials.
US08501322B2	Metal dialkyldithiophosphate intermediate transfer members An intermediate transfer member includes a mixture of a polyimide, a metal dialkyldithiophosphate, a polysiloxane, and an optional conductive filler component.
US08501321B2	Bundle of long thin carbon structures, manufacturing method thereof, and electronic device In the bundle of long thin carbon structures of the present invention, end parts of the bundle are interconnected in a carbon network. The interconnected end parts form a flat surface. By this, an electrical connection structure with low resistance and/or a thermal connection structure with high thermal conductivity are obtained. The bundle of long thin carbon structures can be used suitably as a via, heat removal bump or other electronic element.
US08501319B2	Pre-formed assemblies of solgel-derived nanoparticles as 3D scaffolds for composites and aerogels A composite material that includes a dopant comprised of pre-formed, three dimensional assemblies of skeletal structures that are comprised of solgel derived nanoparticles. The composite material includes a chemically bonded, in situ formed, polymer coating that at least partially coats mesoporous surfaces of the nanoparticles to provide enhancement of random dispersion of the dopant and to minimize or avoid agglomeration. Further, the polymer may be functionalized or the mesoporous surfaces of the nanoparticles may be treated to enable stronger chemical bonding between the dopant and the polymer.
US08501313B2	Wavelength conversion film, agricultural film, structure and coating film forming composition To provide a wavelength conversion film which is capable of maintaining an optical wavelength converting function for a longer period of time than conventional wavelength conversion films.A wavelength conversion film 10 containing an inorganic ultraviolet blocking material and a wavelength converting material, which consists of one or more layers, at least one of which is a base film layer 12 containing a thermoplastic resin.
US08501310B2	Foam waterproofing material with a micro cell structure To be provided is a foam waterproofing material superior in waterproofness and flexible enough to be compatible with further minute clearance.The foam waterproofing material according to the present invention is a waterproofing material including a foam having a thickness of 0.1 to 1.0 mm, characterized in that the foam has a micro cell structure with an average cell diameter of 10 to 60 μm and an apparent density of 0.01 to 0.050 g/cm3. In the foam waterproofing material, the repulsive load when compressed to 0.1 mm (0.1 mm-compressive repulsion force) of the foam is preferably 0.01 to 0.1 MPa. The foam preferably has a closed-cell structure or a semi-open and semi-closed-cell structure. In addition, the foam may have a pressure-sensitive adhesive layer on one or both faces thereof. The pressure-sensitive adhesive layer is preferably formed on the foam via a film layer.
US08501308B2	Grafted cyclodextrin Thermoplastic polymer compositions, films, continues, closures, laminates can comprise a modified vinyl polymer said modified polymer having a moiety comprising a cyclodextrin compound. The cyclodextrin compound, locked into the polymer structure, can absorb impurities, permeants, or other undesirable volatile materials. The cooperation between the cyclodextrin grafted onto the thermoplastic polymer and the polymer structure can provide barrier properties to a film, web or other polymer structure. A permeant or a contaminant can be complexed or trapped within the polymer and held within the film or Web preventing the permeant or contaminant from passing into the interior of a container or enclosure.
US08501306B2	Viscoelastic articles with polymer layer containing elastomer unevenly distributed Provided is a viscoelastic article which exerts different properties between one surface and the other surface thereof, which has a transparent appearance, and which less causes staining of objects to which the viscoelastic article is adopted. The viscoelastic article is an article having a multilayer structure including a polymer layer, and a monomer-absorptive layer capable of absorbing at least one of monomer component(s) constituting the polymer, in which the polymer layer is a polymer layer containing an elastomer unevenly distributed and enriched at an interface, or in the vicinity thereof, opposite to the monomer-absorptive layer. The vicinity of the interface opposite to the monomer-absorptive layer is preferably a region ranging from the interface opposite to the other interface with the monomer-absorptive layer and occupying, in a thickness direction, 50% or less of the total thickness.
US08501304B2	Methods and compositions for forming patterns with isolated or discrete features using block copolymer materials Methods of directing the self assembly of block copolymers on chemically patterned surfaces to pattern discrete or isolated features needed for applications including patterning integrated circuit layouts are described. According to various embodiments, these features include lines, t-junctions, bends, spots and jogs. In certain embodiments a uniform field surrounds the discrete feature or features. In certain embodiments, a layer contains two or more distinct regions, the regions differing in one or more of type of feature, size, and/or pitch. An example is an isolated spot at one area of the substrate, and a t-junction at another area of the substrate. These features or regions of features may be separated by unpatterned or uniform fields, or may be adjacent to one another. Applications include masks for nanoscale pattern transfer as well as the fabrication of integrated circuit device structures.
US08501300B2	Coated polymeric substrates having improved surface smoothness suitable for use in flexible electronic and opto-electronic devices A method of manufacture of a coated polymeric film which comprises performing in sequence the steps of: (i) forming a substrate layer comprising poly(ethylene naphthalate) having a thickness in a range from 50 μm to 250 μm; (ii) stretching the substrate layer in at least one direction; (iii) heat-setting the substrate layer under dimensional restraint at a tension in the range of about 19 to about 75 kg/m of film width, at a temperature above the glass transition temperature of the poly(ethylene naphthalate) but below the melting temperature thereof; (iv) heat-stabilizing the substrate layer under a tension of less than 5 kg/m of film width, and at a temperature above the glass transition temperature of the poly(ethylene naphthalate) but below the melting temperature thereof; and (v) disposing a coating layer on a surface of the substrate layer by a process comprising applying a planarizing coating composition thereto such that a surface of said coating layer exhibits an Ra value of less than 0.6 nm, and/or an Rq value of less than 0.8 nm; and wherein the coating layer has a dry thickness in a range from 1 μm to 20 μm and the number of surface peaks in the range 300 to 600 nm per 5 cm2 area (N(300-600)) of the film after coating is less than 50.
US08501299B2	Conductive paste, multilayer ceramic substrate and its production method A conductive paste comprising 88-94% by mass of Ag powder having an average particle size of 3 μm or less and 0.1-3% by mass of Pd powder, the total amount of the Ag powder and the Pd powder being 88.1-95% by mass. A multilayer ceramic substrate obtained by laminating and sintering pluralities of ceramic green sheets, and having conductor patterns and via-conductors inside, the via-conductors being formed in via-holes having diameters of 150 μm or less after sintering, containing Ag crystal particles having a particle size of 25 μm or more, and having a porosity of 10% or less.
US08501295B2	Wall drop paint barrier protector A drop cloth includes: a sheet of material having a length that is greater than its width; and a series of panels, each panel being connected to the sheet in series along the length of the sheet. The length may be substantially greater than the width. The panels are generally identical to one another and are equally spaced along the length of the sheet such that the spacing is sufficient for the sheet to be folded in-between adjacent panels such that the panes are stacked, the spacing between adjacent panels being about twice the thickness of each panel. The drop cloth can be used for protection against drips and spills when painting along a wall of a room.
US08501289B2	Cooking item comprising a non-stick coating with improved properties of adhesion to the substrate The present invention relates to a cooking item comprising a vitreous coating with improved impact-resistance properties. The present invention also relates to a method for manufacturing such an item.
US08501281B2	Shining coating film formation method and coated article There are provided: a method for forming a shining coating film which can form a coating film extremely excellent in a leveling property and a brightness with good workability and can also realize the reduction of environmental burden; and a coated article excellent in a design property obtained by this method. In a method comprising the steps of sequentially coating a shining material-containing solvent type first base coat coating, a shining material-containing solvent type second base coat coating and a top clear coating onto a base material and baking a formed multilayered coating film at the same time, an improvement is made so that the resin composition and coating nonvolatile concentration of the first and second base coat coatings and the amount of nonvolatiles in the first and second base coating films will have specific conditions.
US08501277B2	Durable, heat-resistant multi-layer coatings and coated articles A method of providing a durable protective coating structure which comprises at least three layers, and which is stable at temperatures in excess of 400° C., where the method includes vapor depositing a first layer deposited on a substrate, wherein the first layer is a metal oxide adhesion layer selected from the group consisting of an oxide of a Group IIIA metal element, a Group IVB metal element, a Group VB metal element, and combinations thereof; vapor depositing a second layer upon said first layer, wherein said second layer includes a silicon-containing layer selected from the group consisting of silicon oxide, silicon nitride, and silicon oxynitride; and vapor depositing a third layer upon said second layer, wherein said third layer is a functional organic-comprising layer. Numerous articles useful in electronics, MEMS, nanoimprinting lithography, and biotechnology applications can be fabricated using the method.
US08501276B2	Carbon film Disclosed is a carbon film which has optical characteristics of retaining a high transparency and being high in refractive index and low in double refractivity, is excellent in electric insulating performance, can be applied to various base materials with good adhesiveness, and can be formed at low temperature. Also disclosed is a laminate including a carbon film and a method for producing the laminate.
US08501272B2	Hemispherical coating method for micro-elements Optically anisotropic spheres that can be used as pixel elements in rotating element displays are fabricated by partially (e.g., hemispherically) coating a plurality of spheres by transfer coating methods. Typically, a monolayer of spaced apart monochromal (e.g., white) spheres is formed on a support surface by, for example, making use of a removable template matrix. Next, a uniform layer of viscous coating material (e.g., black coating) is applied to the monolayer of spheres to transfer at least some of the coating material onto the surface of spheres in a monolayer. The obtained partially coated spheres are optionally cured by a UV or thermal exposure and are then removed from the support substrate. In some embodiments, coating material also provides electrical anisotropy to the spheres. Transfer coating methods result in improved precision of hemispherical coating and allow use of environmentally robust pixel elements.
US08501270B2	Optical transparent member and optical system using the same It is an object to provide an optical transparent member capable of maintaining a high-performance antireflection effect for a base over a long period of time, and an optical system using the same, specifically an optical transparent member including on a base a layer containing SiO2 as a main component, a layer containing Al2O3 as a main component, and a plate crystal layer formed from plate crystals containing Al2O3 as a main component, wherein the surface of the plate crystal layer has a shape of irregularities, and an optical system using the same.
US08501269B2	Sensitive materials for gas sensing and method of making same A gas detection device comprising a measuring circuit, said measuring surface comprising a substrate, a resistance heater bonded to said substrate and a coating, said coating comprising SnO2 nanoparticles doped with In2O3 nanoparticles and Pd oxide, said Pd oxide being formed from a solution of a Pd salt, such as PdCl2. The SnO2 nanocrystals have a specific surface of at least about 50 m2/g, a mean particle size of between about 5 nm and about 20 nm, and the contact points between individual nanoparticles of SnO2 and In2O3 and the associated Pd oxide are less than about 100 Å. The Pd salt solution is a solution of a palladium chloride in a dilute acid solution, such as HCl. The palladium salt to an oxide of palladium at an elevated temperature, as for example, by calcining said oxide of palladium. The palladium Marked Copy oxide is in the form of a coating on nanoparticles of SnO2 and In2O3.
US08501266B2	Method and apparatus Disclosed is a method of providing a constant concentration of a metal-containing precursor compound in the vapor phase in a carrier gas. Such method is particularly useful in supplying a constant concentration of a gaseous metal-containing compound to a plurality of vapor deposition reactors.
US08501262B2	Method and means for improving bowel health A method and composition for improving one or more indicators of bowel health or metabolic health in a mammalian animal. This comprises the delivering to the gastrointestinal tract of the animal an effective amount of an altered wheat starch in the form of or derived from the grain of a wheat plant. The proportion of amylose in the starch of the grain is at least 30% and/or the grain comprises a reduced level of SBEIIa enzyme activity and/or protein relative to wild-type grain.
US08501258B1	Method for preparing milk-based beverages The present invention provides a method for preparing storable products that contain most of the nutritious elements contained in milk. Embodiments combine the different milk elements into liquid products of different looks and tastes that can be stored without refrigeration. All of the products could additionally be supplemented with probiotic components that can be activated upon consumption, allowing storage for extended periods of time without refrigeration. Moreover, because they are mainly composed of highly digestible milk protein, these products can be used to encapsulate different therapeutics and vitamin supplements for patients under aggressive therapeutic regimens such as: immunosuppressants, high level antibiotics, chemotherapy. Due to their balance of carbohydrates, protein and lipids, the products can be beneficial for individuals suffering from diabetes or from lactose intolerance. Finally, the products can also work as an effective tool to maintain weight balance.
US08501250B2	Extractions of fixed oil and thymoquinone rich fractions (TQRF) The present invention reported that SFE is suitable for Nigella sativa seeds oil extraction and fractionation. TQRF that were produced through SFE extractions (600 bars/40° C.) and fractionations (100-200 bars/40-60° C.) possessed high level of TQ and antioxidant activity. SFE fractionation efficiently concentrates the TQ content and antioxidant activity of Nigella sativa seeds oil in short time and low cost manners without using any hazardous organic solvents.
US08501248B1	Botanical composition and method for treating pain and discomfort of various conditions A botanical composition made from a plurality of plant materials selected from Gota Kola (Centella asiatica), Turmeric Root (Curcuma longa), White Willow (Salix alba), Rosehips (Rosa canina), Hibiscus (Hibiscus sabdariffa), Evening Primrose (Oenothera biennis), and Bilberry (Vaccinium myrtillus), or phytochemicals or extracts or oils derived from the plant materials has beneficial application in addressing retinopathy and recurring peripheral neuropathy. The botanical composition can include a number of additional agents such as antioxidants, benfotiamine, thiamine (vitamin B1), and lipoic acid.
US08501247B2	Pest control using natural pest control agent blends Embodiments of the invention relate to a composition for controlling a target pest, wherein the composition includes at least two active ingredients selected from the group consisting of thymyl acetate, linalyl acetate, amyl butyrate, anise star oil, black seed oil, p-cymene, geraniol, isopropyl myristate, d-limonene, linalool, lilac flower oil, methyl salicylate, alpha-pinene, piperonal, piperonyl alcohol, tetrahydrolinalool, thyme oil white, thyme oil red, thymol, vanillin, and winter-green oil, wherein the composition causes synergistic control of the target pest.
US08501243B2	Targeting cancer therapy combination Methods for treating neoplasm, tumors and cancers, using one or more tumor treating drug carriers, haptens and anticancer drugs, alone or in combination with other antineoplastic agents or treatments, are provided. Also provided are compositions, and kits containing the composition for affecting the therapy.
US08501241B1	Treating cancer with a whole, leech saliva extract Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about −20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
US08501239B2	Nanotubes as mitochondrial uncouplers A method of uncoupling mitochondria in a subject including administering nanotubes to the subject in a therapeutically effective amount, wherein the nanotubes are self-rectifying is provided. A method of decreasing reactive oxygen species and decreasing detrimental loading of Ca2+ into mitochondria is provided, including administering a pharmaceutically effective amount of nanotubes into the subject. A method of reducing weight, treating cancer, reducing the effects of traumatic brain injury, or reducing the effects of ageing, in a subject including administering a pharmaceutically effective amount of nanotubes into the subject is also provided.
US08501232B2	Process of forming and modifying particles and compositions produced thereby The present invention relates to processes for forming particles including drugs in a solution, changing the bulk or surface properties of a drug particle, and/or microencapsulating drug particles, and compositions produced thereby. In some embodiments, the process described utilizes mechanical agitation, more specifically low-frequency sonication, under controlled conditions, which provides mild shear forces during forming and/or precipitation to control the particle growth and mixing properties. Particle size can range from less than about 200 nanometers to greater than about one millimeter, depending on the processing conditions and application. This process, and the compositions produced, provide significant advantages in the manufacture of pharmaceutical particulate formulations, as well as biomedical, diagnostic, and chromatography particulate compositions, where sensitive macromolecules, such as proteins or DNA, are involved that would be degraded using more rigorous processing conditions or temperatures.
US08501231B2	Pharmaceutical compositions providing enhanced drug concentrations A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
US08501224B2	Coated pet food composition A composition comprising a physically discrete pet food oral intake composition coated with a physically stable film, the film comprising a component which is a) capable of carrying a beneficial agent to a site in the pet wherein the benefit agent is effective in producing a beneficial effect or b) capable of releasing the benefit agent into the mouth or alimentary canal with the benefit agent traveling to a site in the pet wherein the benefit agent is effective in producing a beneficial effect.
US08501223B2	Methods for dietary management of cats to avoid hyperthyroidism Dietary compositions and methods for reducing risk of developing hyperthyroidism in a feline are disclosed. The compositions and methods restrict the amount of selenium intake or restrict the amount of selenium and iodine intake in the feline.
US08501219B2	Flavoring systems for pharmaceutical compositions and methods of making such compositions A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flavor modifier selected from the group consisting of citric acid, sodium citrate, sodium chloride, and mixtures thereof. At least two of the flavored ingredients are selected from the group consisting of a vanilla flavored ingredient, a peppermint flavored ingredient, a menthol flavored ingredient, a cotton candy flavored ingredient, and mixtures thereof. The one or more sweetening agents comprise glycerin, monoammonium glycyrrhizinate, saccharin sodium, acesulfame potassium, high fructose corn syrup, and/or mixtures thereof. Pharmaceutical compositions of the invention include a flavoring system of the invention, a solvent system, and at least one pharmaceutically active agent, such as lopinavir or derivatives thereof, ritonavir or derivatives thereof, or mixtures thereof. Methods for making such liquid pharmaceutical compositions are also disclosed.
US08501217B2	Implantable graft to close a fistula An implantable graft, which may be inserted into a fistula tract to occlude the primary opening of the fistula, is provided. To prevent unintentional displacement of the graft or extrusion of the graft from the fistula of a patient, the graft may be provided with a cap that extends laterally from at least one end of the body of the graft, where the cap may be integral with the body of the graft, attachable to at least one end of the body of the graft, and/or moveable along the body of the graft. The graft may also have a tail that extends from one end of the body of the graft to assist in placement of the graft in a fistula tract. The graft may be an integral unit made of a single material, such as a heterograft material, or may include distinct components made of the same or different materials. Methods for closing a fistula tract are also provided.
US08501213B2	Multiple drug delivery from a balloon and a prosthesis Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.
US08501212B2	Immobilised biological entities There is described inter alia a medical device having a surface which comprises a coating layer, the coating layer being a biocompatible composition comprising an anti-coagulant entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which anti-coagulant entity is covalently attached to the surface through a linker comprising a thioether.
US08501205B2	Insect repellent composition The present application provides insect repellent compositions that include lemongrass oil and p-menthane-3,8-diol. Vanillin or a vanillin-type component may also be included in the insect repellent composition.
US08501202B2	Sulfacetamide formulations for treatment of skin dermatoses A topical composition for the treatment of mammalian skin dermatoses comprising a sulfacetamide or a derivative thereof and at least 1 sunscreen wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of about 1.6 to about 20.6. Also provided is a method of treating mammalian dermatoses by administering a topical composition comprising a sulfacetamide or a derivative thereof and at least 1 sunscreen wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of about 1.6 to about 20.6.
US08501198B2	Tissue targeted antigenic activation of the immune response to treat cancers The invention provides in part methods of treating cancers of a specific organ or tissue by administering a composition that is antigenically specific for one or more microbes that are pathogenic in the specific organ or tissue in which the cancer is situated. The formulations of the invention thereby facilitate activation of an immune response to a cancer in a particular tissue or organ. The compositions may for example include killed or attenuated microbial pathogens, such as whole killed bacterial cells, and may be administered at sites distant from the cancer, for example the skin. In some embodiments, microbial species of endogenous flora that are known to cause infection in the relevant organ or tissue may be used in the formulation of the antigenic compositions. In alternative embodiments, exogenous microbial pathogens that are known to cause infection in the relevant organ or tissue may be used in the formulation of the antigenic compositions. The administration of the immunogenic compositions may be repeated relatively frequently over a relatively long period of time. In embodiments for intradermal or subcutaneous injection, dosages may be adjusted so that injections reproduce a consistent, visible, delayed inflammatory immune reaction at the successive site or sites of administration.
US08501197B2	Compositions and methods for stimulating immune response against Moraxella catarrhalis This invention provides a method for stimulating in an individual an immune response against M. catarrhalis. The method comprises administering to an individual a composition comprising M. catarrhalis OppA protein in an amount effective to stimulate an immune response against M. catarrhalis in the individual.
US08501192B2	Use of soluble CEACAM8 for diagnosing, treating or monitoring diseases, and a method for screening compounds that prevent apoptosis The invention relates to new uses of soluble CEACAM6 or CEACAM8, or substances that are specific to soluble CEACAM8. Another object of the invention concerns the use of CEACAM1-specific and/or CEACAM6-specific compounds for apoptosis prevention in-vitro. The invention also relates to a method for screening compounds, which prevent apoptosis and a method for preventing apoptosis in human granulocytes.
US08501191B2	FGFR2-IIIb fusion proteins and methods of making them The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their stability. These fusion proteins inhibit the growth and viability of cancer cells in vitro and in vivo. The combination of the relatively high affinity of these receptors for their ligand FGFs and the demonstrated ability of these decoy receptors to inhibit tumor growth is an indication of the clinical value of the compositions and methods provided herein.
US08501189B2	Synthetic human genes and polypeptides and their use in the treatment of autoimmune diseases Synthetic human target autoantigen genes comprising sequences coding for at least two immunogenic epitopic clusters (hereinafter IEC) of autoantigen(s) related to a specific autoimmune disease, wherein said at least two IECs may be derived from a sole autoantigen or from at least two different autoantigens related to said autoimmune disease, and polypeptides encoded thereby, can be used for the treatment and the diagnosis of autoimmune diseases such as multiple sclerosis (MS), insulin-dependent diabetes mellitus (IDDM), rheumatoid arthritis (RA), myasthenia gravis (MG) and uveitis.
US08501188B2	Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for inhibiting or treating inflammatory lung disease by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
US08501184B2	High affinity human antibodies to PCSK9 An human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human proprotein convertase subtilisin/kexin type 9 (hPCSK9) characterized by the ability to reduce serum LDL cholesterol by 40-80% over a 24, 60 or 90 day period relative to predose levels, with little or no reduction in serum HDL cholesterol and/or with little or no measurable effect on liver function, as determined by ALT and AST measurements.
US08501183B2	Immunogenic compositions and diagnostic and therapeutic uses thereof The present invention relates to a method of inducing an immune response to a parasite utilizing an immunogenic composition comprising a glycosylphosphatidylinositol (“GPI”) inositolglycan domain or its derivative or equivalent. The present invention is useful as a prophylactic and/or therapeutic treatment for microorganism infections of mammals such as parasite infections and particularly infection by Plasmodium species. The invention also provides a method of monitoring, or qualitatively or quantitatively assessing an immune response to a microorganism such as a parasite. More particularly, this aspect of the present invention is directed to assessing said immune response utilizing a GPI inositolglycan domain or its derivative or equivalent, which facilitates the qualitative and/or quantitative analysis of anti-GPI antibodies in a biological sample, the identification of unique specificities of antibodies, epitope specific screening or the rational design of immunogenic molecules and the generation, thereby, of functionally effective immunointeractive molecules.
US08501171B2	Use of ADCC-optimized antibodies for treating weak patients The invention concerns the use of human or humanized chimeric monoclonal antibodies which are produced in selected cell lines, said antibodies bringing about a high ADCC activity as well as a high secretion of cytokines and interleukins, for treating underpopulations of so-called weak-response patients exhibiting CD16 FCGR3A-158F homozygote or FCGR3A-158V/F heterozygote polymorphism.
US08501169B2	Microorganisms for improving the health of individuals with disorders related to gluten ingestion The invention relates to microorganisms for the treatment of food allergies, specifically coeliac disease, as well as to methods for the selection thereof. The action mechanisms of said microorganisms include: (i) the regulation of the innate and adaptive immunological responses; (ii) the reduction of the concentration of toxic gluten peptide epitopes in the intestinal lumen; (iii) the strengthening of the barrier defence function against harmful antigens and bacteria; and (iv) the provision of enzymatic activities that promote digestion.
US08501168B2	Cell lines, compositions comprising them for the treatment of melanomas, procedures to prepare the compositions, and treatment methods Cell lines, compositions comprising them for the treatment of melanomas, procedures to prepare the compositions, and treatment methods. More particularly, the invention relates to diverse human melanoma cell lines for the treatment of malignant diseases, wherein the cell lines are: (a) Mel-XY1 (deposited at German Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2830), (b) Mel-XY2 (deposited at German Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2831), (c) Mel-XY3 (deposited at German Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2832), (d) Mel-XX4 (deposited at German Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2829), or (e) sub-populations thereof. The cell lines may be irradiated, thus obtaining populations with apoptotic phenotype, and populations with necrotic phenotype of such lines. The compositions may comprise adjuvants and/or immuno-modifiers, and/or autologous dendritic cells.
US08501165B2	In situ bonds A biocompatible tissue-bonding adhesive composition comprising a polyol of functionality N. The polyol being terminated has at least one polyisocyanate in solution with at least (N−1)% of the solution comprising free polyisocyanate. N may be in the range 1.5-8. The polyol may be a branched polypropylene/polyethylene oxide copolymer.
US08501161B2	Oral care regimen The invention includes methods of cleaning an oral surface, maintaining oral health and/or increasing oral health. Such methods encompass contacting an oral surface with a primary oral care composition at least once daily, and contacting the oral surface with a periodic oral care composition at least once within a period of about 42 days. The periodic oral care compositions suitable for use in the method comprise a first abrasive having an Einlehner hardness of greater than about 5 mg loss per 100,000 revolutions and a second abrasive having an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. In the periodic oral care compositions, the ratio of the first abrasive to the second abrasive is about 1:1.6 to about 1.6:1. The periodic oral care compositions are characterized by a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200. Additionally or alternatively, the methods may include those where the second abrasive comprises silica and has an oil of absorption of greater than about 90 cm3/100 g and/or an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. The ratio of the first abrasive to the second abrasive may be about 1:1.6 to about 1.6:1. The total amount of the first and second abrasives present in the oral composition may be greater than about 25% by weight of the composition and/or the oral composition has a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200.
US08501160B2	Crush-resistant oxycodone tablets intended for preventing accidental misuse and unlawful diversion Water-insoluble matrix tablets based on oxycodone or one of its pharmaceutically acceptable salts and capable of prolonged release of oxycodone to the body, exhibiting a crush resistance of at least 4 MPa.
US08501159B2	Magnetic nanoparticles for the application in hyperthermia, preparation thereof and use in constructs having a pharmacological application There are described nanoparticles of magnetic metal oxides employable in constructs consisting in polymer particles possibly also incorporating pharmacologically active substances.
US08501156B2	Method for non-invasive detection and treatment of cerebral aneurysms Described herein is a method for non-invasive detection and treatment of intra-cranial aneurysms. Antibodies are provided to specifically react/bind with antigens of the cerebral aneurism wall. The antibodies may be bound to a label and/or to a therapeutic agent for diagnosis and/or for treatment purposes thereof. Intra-cranial aneurysms are thus non-invasively detected before rupture occurs and are specifically treated.
US08501155B2	Biochemical markers for acute pulmonary embolism The present invention relates to a method of differentiating between a singular and a multiple lung embolism in a subject suspected to suffer from acute lung embolism comprising determining the amount of NT-proBNP in a sample of a subject suspected to suffer from acute lung embolism and comparing the amount to a reference amount. Further, the present invention also relates to a method of differentiating between acute and chronic lung embolism in a subject comprising determining the amount of NT-proANP at a first and a second time point and comparing the determined amounts with each other. The present invention also encompasses devices and kits for carrying out the aforementioned methods.
US08501154B2	Fluorinated fructose derivatives for PET imaging The present invention is directed to fructose-based radiopharmaceuticals, pharmaceutical compositions comprising same, precursors and methods for preparing same, and methods of using same for diagnostic imaging of cancer cells and non-imaging tracer studies.
US08501153B2	Active enantiomer The present invention provides a PET tracer that has improved properties for imaging the peripheral benzodiazepine receptor (PBR) as compared with known such PET tracers. The present invention also provides a precursor compound useful in the preparation of the PET tracer of the invention and methods for the preparation of said precursor compound and said PET tracer. Also provided by the present invention is a radiopharmaceutical composition comprising the PET tracer of the invention. Methods for using the PET tracer and the radiopharmaceutical composition are also provided.
US08501144B1	Polycrystalline diamond apparatuses and methods of manufacture Methods of manufacturing polycrystalline diamond are disclosed. More particularly, a mixture including diamond and fullerenes may be provided. Further, the mixture may be exposed to a high pressure, high temperature sintering process. In addition, a volume of polycrystalline diamond bonded to a substrate may be formed by providing a mixture including diamond and fullerenes and exposing the mixture to a high pressure, high temperature sintering process. A drill bit for drilling a subterranean formation is disclosed. Further, polycrystalline diamond compacts are disclosed including polycrystalline diamond bonded to a substrate, wherein the polycrystalline diamond includes less than about 1% by weight or is substantially free of non-fullerenes, non-diamond carbon. Polycrystalline diamond exhibiting an increased diamond volume fraction due to the presence of fullerenes during manufacture relative to polycrystalline diamond formed without fullerenes is disclosed.
US08501141B2	Method for producing group III nitride semiconductor An object of the present invention is to effectively add Ge in the production of GaN through the Na flux method. In a crucible, a seed crystal substrate is placed such that one end of the substrate remains on the support base, whereby the seed crystal substrate remains tilted with respect to the bottom surface of the crucible, and gallium solid and germanium solid are placed in the space between the seed crystal substrate and the bottom surface of the crucible. Then, sodium solid is placed on the seed crystal substrate. Through employment of this arrangement, when a GaN crystal is grown on the seed crystal substrate through the Na flux method, germanium is dissolved in molten gallium before formation of a sodium-germanium alloy. Thus, the GaN crystal can be effectively doped with Ge.
US08501139B2	Floating Si and/or Ge foils One embodiment of the present invention is a method for producing a silicon (Si) and/or germanium (Ge) foil, the method including: dissolving a Si and/or Ge source material in a molten metallic bath at an elevated temperature T2, wherein the density of Si and/or Ge is smaller than the density of the molten metallic bath; cooling the molten metallic bath to a lower temperature T1, thereby causing Si and/or Ge to separate out of the molten metallic bath and to float and grow as a Si and/or Ge foil on a top surface of the molten metallic bath; and separating the floating Si and/or Ge foil from the top surface of the molten metallic bath.
US08501136B2	Synthesis and processing of rare-earth boride nanowires as electron emitters A method for preparing single-crystalline, rare-earth metal hexaboride nanowires by a chemical vapor deposition process is described. Also described are the nanowires themselves, the electron emitting properties of the nanowires, and the use of the nanowires in electron emitting devices, particularly as point electron sources.
US08501135B1	Process for the removal of sulfur compounds from gas streams A method of reducing sulfur compounds from an incoming gas stream, comprising flowing the gas stream over a hydrolysis catalyst to convert COS and CS2 to H2S and reduce SO2 to elemental sulfur to form an effluent stream; providing an acidic gas removal unit comprising an absorbent; flowing said effluent stream over said absorbent to produce a stream free of acidic gases; applying an acidic-gas desorption mode to said acidic-gas rich absorbent to produce an acidic gas stream; introducing oxygen to said acidic gas-rich stream; providing a direct oxidation vessel containing catalyst suitable for catalyzing the oxidation of the H2S to sulfur wherein the temperature of the vessel is at or above the sulfur dew point at the reaction pressure; and flowing said acidic gas-rich stream over said catalyst to produce a processed stream having a reduced level of sulfur compounds.
US08501124B2	Method for recovering rare-earth elements from a solid mixture containing a halophosphate and a compound of one or more rare-earth elements A method is described for recovering rare earth elements from a solid mixture including a halophosphate and at least one compound of one or more rare earth elements. The method includes: (a) acid etching the mixture; (b) adding a base to bring the pH back up to a value of at least 1.5; (c) etching the solid from step (b) with a solution of soda or potash; (d) acid etching the solid from step (c) until a pH of less than 7 is obtained, resulting in a solid phase and a liquid phase including at least one rare earth salt, and separating the solid phase from the liquid phase.
US08501123B2	HF alkylation process with internal acid regeneration An improved process for removing polymeric by-product (ASO) from the HF alkylation acid in an HF alkylation unit used for the production of gasoline boiling range alkylate product by olefin/iso-paraffin alkylation, comprises fractionating a portion of the circulating HF alkylation acid inventory of the unit with a portion of hot alkylate product in a fractionation zone to from an overhead product comprising HF alkylation acid and water and a bottoms fraction comprising the polymeric by-product and alkylate. The bottoms fraction is sent to the isoparaffin stripper of the unit to remove trace HF alkylation acid as overhead and form a product stream of hot alkylate as a bottoms fraction.
US08501113B2	Fluorescence spectroscopy in absorbing media The invention relates to processes and devices for detecting an analyte in a sample by fluorescence measurement of a fluorophore, wherein the detection medium which contains a fluorophore or a precursor of the fluorophore is admixed with an absorber whose absorbance spectrum superimposes the fluorescence excitation range of the fluorophore. The system consisting of the fluorophore and the absorber, which is produced in the detection medium, has an altered effective fluorescence excitation range with an altered fluorescence excitation maximum. Illumination with fluorescence excitation light can take place within the range of this altered excitation maximum. The measured signal obtained from determining fluorescence emission exhibits only low dependence on the wavelength of the excitation light.
US08501107B2	Apparatus for generating mercury (II) sulfide from elemental mercury An apparatus is provided for generating mercury (II) sulfide from elemental mercury. Elemental mercury is injected into a heated and sealed reaction vessel containing vaporized sulfur. The elemental mercury reacts with at least a portion of the vaporized sulfur to form the mercury (II) sulfide within the reaction vessel. The formed mercury (II) sulfide is then unloaded from the reaction vessel.
US08501103B2	Material, system, and method that provide indication of a breach A multilayer material is described herein that includes a flexible inner layer and a flexible outer layer configured to enclose at least one signaling layer, the at least one signaling layer including at least one chemical compound. The multilayer material including the chemical compound within the at least one signaling layer is configured to release a gas-phase chemical compound to signal to a detector indicating a breach of the multilayer material. A multilayer material, a system, an article of clothing, or a method is described herein.
US08501102B2	Hydrogen generator and startup method thereof A hydrogen generator is described, which comprises: a material supply device (4); a water supply device (5); an evaporator (10); a reforming catalyst layer (1) for generating reformed gas; a CO removing catalyst layer (2) configured to reduce the amount of carbon monoxide contained in the reformed gas generated by the reforming catalyst layer (1); a combustor (3) for heating the reforming catalyst layer (1) and the CO removing catalyst layer (2); a reforming temperature detector (9) for detecting the temperature of the reforming catalyst layer (1); a heater (7) for heating the CO removing catalyst layer (2); a CO removing temperature detector (8) for detecting the temperature of the CO removing catalyst layer (2); and a controller (16) configured to perform control such that the heater (7) heats the CO removing catalyst layer at the time of start-up and such that if the temperature detected by the CO removing temperature detector (8) becomes greater than or equal to a first specified value, the combustor (3) heats the reforming catalyst layer (1) and the CO removing catalyst layer (2), and if the temperature detected by the reforming temperature detector (9) becomes greater than or equal to a second specified value, the water supply device (5) starts supplying of water.
US08501100B2	Oxygen detection using metalloporphyrins An oxygen sensor includes a metalloporphyrin for detecting oxygen levels. The oxygen sensors may also include a light source and a detector. The sensors are configured to measure changes in spectra in response to the redox reaction. They can detect a variety of samples for presence and changes in oxygen concentration in both solution and gaseous form.
US08501099B2	Photo-acoustic detection device and method An example system for detecting an analyte in a sample of a bodily fluid comprises a test chamber having at least one sidewall and configured to contain at least a portion of a bodily fluid sample, an excitation electromagnetic energy source configured to direct an energy source into the test chamber through the at least one sidewall and to induce a thermoelastic expansion in the one or more analytes, and a sensor configured to detect said thermoelastic expansion in the bodily fluid sample in the test chamber, the sensor configured to measure changes in optical reflectance that result from the thermoelastic expansion.
US08501090B2	Anti-microbial gas apparatus and method An apparatus and method administering nitric oxide at very high concentrations to healthy skin, tools, implements, support surfaces, and sterile fields to provide sterilization. The apparatus and method providing sterilization in a dry environment lacking the common undesirable effects of anti-microbial soaps and antiseptics.
US08501089B2	Methods of disinfecting packages in aseptic packaging using antimicrobial peracid compositions with selected catalase enzymes The present invention relates to specially selected catalase enzymes and their use in reducing hydrogen peroxide in applications, and particularly in aseptic packaging applications.
US08501088B2	Solder alloy, solder ball and electronic member having solder bump To provide a solder alloy, a solder ball and an electronic member having a solder bump, used for connection with a mother board or the like, having a melting temperature of less than 250° C. for the solder alloy, achieving high drop impact resistance required in mobile devices or the like. A solder alloy is used which consists of not less than 0.1 mass ppm of boron and not greater than 200 mass ppm of boron and a remainder comprising substantially not less than 40% by mass of Sn, in which its melting temperature is less than 250° C.
US08501087B2	Au-base bulk solidifying amorphous alloys Compositions for forming Au-based bulk-solidifying amorphous alloys are provided. The Au-based bulk-solidifying amorphous alloys of the current invention are based on ternary Au—Cu—Si alloys, and the extension of this ternary system to higher order alloys by the addition of one or more alloying elements. Additional substitute elements are also provided, which allow for the tailoring of the physical properties of the Au-base bulk-solidifying amorphous alloys of the current invention.
US08501081B2	Polycrystalline alumina articles and methods of manufacture Polycrystalline alumina and methods for manufacturing polycrystalline alumina exhibiting improved transmission in the infrared region. In one embodiment, polycrystalline alumina articles are formed by providing a powder of substantially alpha phase alumina having a grain size of up to about 1 μm, dispersing the powder in a liquid to form a slurry comprising powdered solids and liquid, removing excess of the liquid from the slurry to form a body, heating the body to provide a densified body, hot isostatically pressing the densified body under conditions to provide an article having a density of at least about 99.9% of theoretical density, and optionally annealing the article, wherein one or more of the annealing or heating are performed in an inert, dry gas.
US08501076B2	Composite exterior cladding panel A new cladding panel for use on recreational vehicles is produced by either a hand-laid or vacuum infusion process. In the hand-laid method, the cladding is formed by first introducing and curing a layer of gel coat onto a mold surface. Layers of fiber reinforced resin material are subsequently laid onto the gel coating and molded to form the cladding panel. In the vacuum infusion process, the gel coating is first laid onto a mold surface of a vacuum infusion mold, and then dry ply materials are laid onto the gel coating. The mold is closed and a resin component is infused into the dry laminate material under vacuum pressure and cured. The cladding panels produced by these methods produced are seamless and have limited waste associated with post-production trimming processes. Cladding panels produced using the vacuum infusion process have a more consistent composition and achieve improved part-to-part consistency.
US08501074B2	Siloxane polymerization in wallboard Polymerization of siloxane is improved using a gypsum-based slurry that includes stucco, Class C fly ash, magnesium oxide and an emulsion of siloxane and water. This slurry is used in a method of making water-resistant gypsum articles that includes making an emulsion of siloxane and water, then combining the slurry with a dry mixture of stucco, magnesium oxide and Class C fly ash. The slurry is then shaped as desired and the stucco is allowed to set and the siloxane polymerizes. The resulting product is useful for making a water-resistant gypsum panel having a core that includes interwoven matrices of calcium sulfate dihydrate crystals and a silicone resin, where the interwoven matrices have dispersed throughout them a catalyst comprising magnesium oxide and components from a Class C fly ash.
US08501070B2	Resin transfer molding device and resin transfer molding method A resin transfer molding (RTM) molding device is designed to mold a fiber-reinforced plastic (FRP) molded body by injecting a resin composition into a mold and by impregnating the molded body therewith. The resin composition is a chain curing polymer (CCP). A CCP accommodating layer is disposed adjacent to an outer side of the molded body. The layer contains the CCP. The layer is provided with a Vf limit value, the value defined by the curing characteristics of the CCP and the characteristics of dissipation of heat from the CCP to the exterior. An element for separating the molded body is disposed between the body and the layer.
US08501067B2	Method for producing a mould element A method for producing a mold element provided with a conduit arrangement through which a cooling fluid can flow. The method includes providing a first component and a second component of the mold element, the first component being provided with a precursor arrangement of the conduit arrangement, the precursor arrangement having an open channel arrangement; joining the first component and the second component, so that a surface of the second component faces the open channel arrangement to define therewith the conduit arrangement. The step of joining includes making integral the first component with the second component via a third component formed in contact with the first component and with the second component in an auxiliary mold.
US08501065B2	Film and method for producing film A method for producing a film comprising feeding a composition comprising a crystalline thermoplastic resin having a temperature of higher than the crystallization temperature Tc of the resin to between a first nip-pressing surface and a second nip-pressing surface of a nip-pressing unit, and leading the composition to pass through the nip-pressing surfaces while the nip-pressing unit gives a pressure of from 5 to 1000 MPa to the composition, to thereby form the composition into a film continuously.
US08501062B2	Method for making a composite article A composite includes a first preform and a second preform spaced from and in overlying relationship to the first preform. The second preform defines at least one first opening extending therethrough along an axis transverse to the first preform. A first surface layer is disposed adjacent to the second preform and on an opposite side of the second preform from the first preform. A polymeric composition including the reaction product of an isocyanate component and an isocyanate-reactive component is disposed between the first preform and the second preform. The polymeric composition adheres the first surface layer to the second preform through the at least one first opening. The surface layer is adhered to the second preform during molding of the composite article and in the absence of additional adhesive, thereby reducing production time and cost of the composite article.
US08501059B2	Injection unit having a filter, a method of controlling melt pressure in accordance with a target pressure range There is provided a method (300) of controlling melt pressure at a filter outlet (113) of a melt filter (112) in an injection unit (100) having an extruder (102) that is connectable to a melt accumulator (122) via the melt filter (112), the melt filter (112) being associated with a target melt pressure range, the method executable at a controller (126) associated with the injection unit (100), the method (300) comprising: appreciating (310) an indication of an actual melt pressure associated with the melt filter (112); responsive to the actual melt pressure not being within the target melt pressure range, determining (320) a remedial parameter that is instrumental in bringing the actual melt pressure within the target melt pressure range; releasing (330) a control signal to execute an action associated with the remedial parameter, thereby causing the actual melt pressure to fall within the target melt pressure range.
US08501056B2	Homogenized product for implants and microparticles The invention relates to a method for the solvent-free preparation of a homogenizate, especially for implants or microparticles, wherein one or more polymers and one or more active constituents, as raw materials, are homogenized together below the glass transition temperature of the polymer(s) and, when homogenization is complete, brought to room temperature.
US08501055B2	Toner manufacturing method, a toner manufacturing apparatus, and a toner A toner manufacturing method, a toner manufacturing apparatus, and a toner are disclosed. The toner manufacturing apparatus includes a droplet generating unit that includes a thin film in which plural nozzles are formed, and an annular vibrating unit that is arranged at a perimeter of a deformable domain of the thin film for vibrating the thin film; a storage unit for storing a toner-containing liquid that includes at least a resin and a colorant, and for supplying the toner-containing liquid 10 to the droplet generating unit; and a granulating unit for solidifying droplets that are periodically breathed out from the nozzles of the droplet generating unit to form toner particles.
US08501054B2	Apparatus and method for manufacturing micro lens array An apparatus for manufacturing a micro lens array, wherein lenses having various standards are easily manufactured by forming a micro lens array by adjusting a vacuum condition in a vacuum chamber. The apparatus including: a vacuum chamber including a vacuum space therein; a vacuum unit for forming a vacuum inside the vacuum chamber; an upper frame disposed inside the vacuum chamber and to which a substrate is installed on a lower surface of the upper frame; an elevator for ascending and descending the upper frame; a lower frame disposed below the upper frame; a master plate disposed on the lower frame and includes a plurality of molding grooves on an upper surface of the master plate; and a heater installed to a side of the master plate to heat up the master plate.
US08501053B2	Multi color, photoactive, color changing compositions and UV dosimeters A multi color, photoactive, color changing plastic, coating or ink, composition comprising both a photochromic material and a photosensitive chromogenic system is provided which will undergo a sequence of color changes upon exposure to ultraviolet radiation. Also provided is an ultraviolet indicator or dosimeter comprising the color changing composition.
US08501052B2	Thin film comprising titanium oxide as main component and sintered compact sputtering target comprising titanium oxide as main component A thin film comprising titanium oxide as its main component, wherein the thin film includes titanium, oxygen and copper, content of Ti is 29.0 at % or higher and 34.0 at % or less and content of Cu is 0.003 at % or higher and 7.7 at % or less with remainder being oxygen and unavoidable impurities, and ratio of oxygen component to metal components, O/(2Ti+0.5Cu), is 0.96 or higher. This invention aims to obtain a thin film comprising titanium oxide as its main component with a high refractive index and low extinction coefficient and a sintered compact sputtering target comprising titanium oxide as its main component which is suitable for producing the foregoing thin film, to obtain a thin film with superior transmittance and low reflectance and which is effective as an interference film or protective film of an optical information recording medium, and to obtain a thin film that can be applied to a glass substrate; that is, a thin film that can be used as a heat ray reflective film, antireflection film, and interference filter.
US08501048B2	Metal-graphite composite material having high thermal conductivity and production method therefor The present invention provides a metal-graphite composite material favorable to two-dimensional diffusion of heat and having a high thermal conductivity in two axial directions, and a production method therefor. The metal-graphite composite material of the present invention includes: 20 to 80% by volume of a scaly graphite powder; and a matrix selected from the group consisting of copper, aluminum and alloys thereof, wherein the scaly graphite powder in which a normal vector to a scaly surface thereof is tilted at 20° or higher with respect to a normal vector to a readily heat-conducting surface of the metal-graphite composite material is 15% or less relative to a whole amount of the scaly graphite powder, and the metal-graphite composite material has a relative density of 95% or higher.
US08501047B2	Mixed carbon material and negative electrode for a nonaqueous secondary battery A negative electrode material provided by the present invention capable of suppressing a decrease in charge acceptance and high temperature storage properties in an electrode with a high capacity and a high density is a mixed carbon material comprising carbon material A having cores of graphite powder with amorphous carbon and/or turbostratic carbon adhered to or coated on the surface of the cores and carbon material B which is graphite powder, the compressibility which is the density (g/cm3) of the material when 1.00 grams of the material are packed into a cylindrical mold with an inner diameter of 15 mm and compressed by applying a pressing force of 8.7 kN and reducing the pressing force to 0.15 kN is 1.60-1.78 g/cm3 for carbon material A and 1.75-1.85 g/cm3 for carbon material B, the compressibility of carbon material A is less than the compressibility of carbon material B, and the mixing ratio (carbon material A/carbon material B) is 1-9 as a mass ratio.
US08501042B2	Phosphor, white light emitting device including the phosphor and method of preparing the phosphor A phosphor represented by Formula 1: ZnS:Cu,Cl,Mn,Te. Formula 1
US08501038B2	Liquid crystal compound, liquid crystal composition and liquid crystal display device The invention provides a liquid crystal compound having a high stability to heat, light or the like, a wide temperature range of a nematic phase, a small viscosity, a large optical anisotropy and a suitable elastic constant K33, and further having a suitable negative dielectric anisotropy and an excellent compatibility with other liquid crystal compounds. The invention also provides a liquid crystal composition including this liquid crystal compound and a liquid crystal display device containing this liquid crystal composition;a liquid crystal compound represented by formula (a):
US08501035B2	Absorption medium for removing acid gases from a fluid stream An absorption medium for removing acid gases from a fluid stream comprises an aqueous solution (A) of an alkali metal salt of an N,N-di-C1-C4-alkylaminocarboxylic acid and (B) N-hydroxyethylpiperazine. The absorption medium has a low vapor pressure and an increased resistance to oxygen. Preferred fluid streams are combustion exhaust gases or biogas.
US08501033B2	Radiation curable resin composition and rapid three-dimensional imaging process using the same The invention relates to a liquid radiation curable resin capable of curing into a solid upon irradiation comprising: (A) from about 0 to about 12 wt % of a cycloaliphatic epoxide having a linking ester group; (B) from about 30 to about 65 wt % of one or more epoxy functional components other than A; (C) from about 10 to about 30 wt % of one or more oxetanes; (D) from, about 1 to about 10 wt % of one or more polyols; (E) from about 2 to about 20 wt % of one or more radically curable (meth)acrylate components; (F) from about 2 to about 12 wt % of one or more impact modifiers; (G) from about 0.1 to about 8 wt % of one or more free radical photoinitiators; and (H) from about 0.1 to about 8 wt % of one or more cationic photoinitiators; wherein the liquid radiation curable resin has a viscosity at 30° C. of from about 600 cps to about 1300 cps.
US08501032B2	Catalysts for alkene isomerization and conjugating double bonds in polyunsaturated fats and oils The invention provides ruthenium-comprising catalysts, and methods of making and using them, for conjugating double bonds in polyunsaturated hydrocarbons, including polyunsaturated fatty acid derivatives, such as natural fats and oils which comprise (contain) more than one carbon to carbon double bond—where the double bonds are separated by, e.g., a methylene, ethylene or propylene or longer group. The invention provides compositions and methods for treating fats and oils comprising “interrupted” (e.g., “methylene-, ethylene- or propylene-interrupted”) double bonds to generate isomers with “conjugated” double bonds. The invention also provides compositions, and methods of making and using them, for making catalysts on a solid support. In one aspect, these catalysts are for alkene isomerization or exchange of alkene hydrogens for other isotopes. The invention provides heterocyclic resin-based compositions, and methods of using them, for making catalysts for alkene isomerization and exchange of hydrogens for deuterium or tritium isotopes.
US08501028B2	Method for grinding a semiconductor wafer A method for processing a semiconductor wafer includes bringing at least one grinding tool in contact with the semiconductor wafer; removing material from the semiconductor wafer using the grinding tool; disposing a liquid medium having a viscosity of at least 3×10−3 N/m2·s and at most 100×10−3 N/m2·s between the at least one grinding tool and the semiconductor wafer; and separating the at least one grinding tool and the semiconductor wafer so as to end the processing.
US08501026B2	Method for making a planar membrane A method for determining a minimum tension compensation stress which will have a membrane of a thickness of less than or equal to one micrometer, secured to a frame, having, in the absence of any external stress, a desired deflection. The membrane can be made as planar as possible in absence of any external stress, and its thickness can be less than or equal to one micrometer.
US08501024B2	Method of manufacture of atomically thin boron nitride The present invention provides a method of fabricating at least one single layer hexagonal boron nitride (h-BN). In an exemplary embodiment, the method includes (1) suspending at least one multilayer boron nitride across a gap of a support structure and (2) performing a reactive ion etch upon the multilayer boron nitride to produce the single layer hexagonal boron nitride suspended across the gap of the support structure. The present invention also provides a method of fabricating single layer hexagonal boron nitride. In an exemplary embodiment, the method includes (1) providing multilayer boron nitride suspended across a gap of a support structure and (2) performing a reactive ion etch upon the multilayer boron nitride to produce the single layer hexagonal boron nitride suspended across the gap of the support structure.
US08501023B2	Method for forming a mirror MEMS device An apparatus for use with a digital micromirror device includes a hinge layer that is disposed outwardly from a substrate. The hinge layer including a hinge that is capable of at least partially supporting a micromirror that is disposed outwardly from the hinge. In one particular embodiment, the hinge and the substrate are separated by a first air gap. The device also including a first hinge support that is disposed outwardly from the substrate and inwardly from at least a portion of the hinge layer. The first hinge support being capable of transmitting a voltage to the hinge. At least a portion of the hinge support coupled to at least the portion of the hinge layer. In one particular embodiment, the first hinge support is formed in a process step that is different than a process step that forms the hinge layer.
US08501021B2	Process and system for quality management and analysis of via drilling A process for laser forming a blind via in at least one layer of a circuit substrate having a plurality of capture pads of varying geometry can include, for at least one blind via to be formed in at least one layer of a circuit substrate, evaluating a capture pad geometry value (such as area and/or volume) within a predetermined distance from a drilling location with respect to a blind via geometry value (such as area and/or volume) to be formed at the drilling location. The process can include setting at least one laser operating parameter based on the evaluation in order to obtain a desired capture pad appearance after blind via formation. The process can include imaging a capture pad area defined as an area within a predetermined distance from a blind via drilling location in at least one layer of a circuit substrate, quantifying at least one appearance value for the imaged capture pad area, and determining an acceptability of the imaged capture pad areas based on the quantified appearance value.
US08501020B2	Method for making three-dimensional nano-structure array A method for making a three-dimensional nano-structure array includes following steps. First, a substrate is provided. Next, a mask is formed on the substrate. The mask is a monolayer nanosphere array or a film defining a number of holes arranged in an array. The mask is then tailored and simultaneously the substrate is etched by the mask. Lastly, the mask is removed.
US08501019B2	Device for separating fluid mixtures, in particular oil/water mixtures The present invention relates to a device for separating fluid mixtures, in particular for separating oil and water in a vacuum container, into which the fluid mixture is injected by means of an adjustable truncated-cone round jet nozzle.
US08501016B2	Storm water pretreatment chamber A storm water pretreatment chamber is provided. The storm water pretreatment chamber includes; one or more filter sidewalls; one or more optional water-impermeable sidewalls; one or more optional chamber grates; and one or more catch rails. Methods of treating storm water are also provided.
US08501011B2	Wet air oxidation process using recycled catalyst A system and method for the treatment of process streams. A catalyst mediates a wet oxidation process at elevated temperatures and pressures for treating at least one undesirable constituent in an aqueous mixture. The aqueous mixture may be contacted with a catalyst and an oxidizing agent at an elevated temperature and a superatmospheric pressure. At least a portion of the catalyst may be precipitated by a pH adjustment and recycled back to contact the aqueous mixture.
US08501008B2	Method for the elimination of leukocytes from blood The invention relates to a method for reducing the number of leukocytes in blood through treating the blood in an arrangement of a plurality of fibers based on organic polymers, whereby the blood is channeled along the fibers and whereby the reduction in leukocytes from the blood occurs essentially through adsorption on the fibers, characterized in that the plurality of fibers based on organic polymers is fixed in a housing with an inlet arrangement and an outlet arrangement, and that the blood is channeled via the inlet arrangement into the housing, flows through the housing with the plurality of fibers made from organic polymers, and exits the housing via the outlet arrangement, that the arrangement of the fibers shows a high degree of order, that the blood flows along the external surface of the fibers, and that the fibers cause a generation of the complement activation product C5a in a concentration of at least 10 μg per m2 of fiber surface.
US08501006B2	Apparatus and method for processing liquid waste A wastewater treatment system is described. The treatment system can include an aerobic digestion system, an anaerobic digestion system, and a ventilation system.
US08501005B2	Water purification apparatus and system The invention relates to a two-stage design for a water purification system, with water to be purified first passing through a first stage containing particulate filtration media, and a second stage containing a porous filtration block. The particulate filtration media can be the same as, or different from, material included in the porous block. Either material may be any material that removes contaminants from water by, e.g., absorption, adsorption, ion exchange, sequestration, or other mechanism, or any combination of these.
US08500991B2	High activity MTT framework type molecular sieves A process is described of producing an MTT framework type molecular sieve by crystallizing a mixture capable of forming said molecular sieve, wherein the mixture comprises sources of alkali or alkaline earth metal (M), an oxide of trivalent element (X), an oxide of tetravalent element (Y), water and a directing agent (R) of the formula (CH3)3N+CH2CH2CH2N+(CH3)2CH2CH2CH2N+(CH3)3, and has a composition, in terms of mole ratios, within the following ranges. YO2/X2O3less than 45 H2O/YO25 to 100 OH−/YO20.05 to 0.5 M/YO20.05 to 0.5 and R/YO2>0 to <0.5.
US08500986B1	Methods for the implementation of nanocrystalline and amorphous metals and alloys as coatings Methods for the use of nanocrystalline or amorphous metals or alloys as coatings with industrial processes are provided. Three, specific, such methods have been detailed. One of the preferred embodiments provides a method for the high volume electrodeposition of many components with a nanocrystalline or amorphous metal or alloy, and the components produced thereby. Another preferred embodiment provides a method for application of a nanocrystalline or amorphous coatings in a continuous electrodeposition process and the product produced thereby. Another of the preferred embodiments of the present invention provides a method for reworking and/or rebuilding components and the components produced thereby.
US08500981B2	Electrophoresis apparatus and electrophoresis method An electrophoresis apparatus includes a sample separating section for containing a sample separating medium for separating a sample in a horizontal direction, the sample separating section containing the sample separating medium in such a manner that the sample separating medium has an exposed portion at least one end of a surface of the sample separating medium, the surface being in parallel with the horizontal direction; and medium connecting means for connecting a sample containing medium to the sample separating medium at a connecting region, the sample containing medium containing a sample, and the connecting region satisfying a particular equation. By this, an electrophoresis technique with better accuracy than conventional arts can be provided.
US08500977B2	Coating apparatus A coating apparatus includes a housing, a sputter mechanism, an evaporation mechanism, and a workpiece transport assembly. The housing defines a receiving space. The workpiece transport assembly includes a fixing plate, a first transport member, and a first shaft. The fixing plate is secured to the housing via the receiving space and divides the receiving space into a sputter chamber and an evaporation chamber. The sputter mechanism is mounted in the sputter chamber, and the evaporation mechanism is mounted in the evaporation chamber. The fixing plate defines a through hole. The sputter chamber communicates with the evaporation chamber via the through hole. The first transport member is configured to transport at least one workpiece. The first shaft is secured to the first transport member and rotatably mounted to the housing.
US08500972B2	Cylindrical magnetron A rotatable cylindrical magnetron sputtering device that includes a cathode body defining a magnet receiving chamber and a cylindrical target assembly surrounding the cathode body, wherein the cylindrical target assembly is rotatable around the cathode body. The cylindrical target assembly includes a hollow mandrel and a target portion mounted around and spaced away from the hollow mandrel portion so as to create a space gap between the hollow mandrel and the target portion, wherein the space gap may be greater than 0.002 inch and less than 0.020 inch.
US08500968B2	Deplating contacts in an electrochemical plating apparatus An electroplating apparatus having improved contact deplating features includes a bowl assembly having a bowl for holding an electroplating solution. A head having a rotor including a contact ring and a head motor for rotating the rotor cooperates with the bowl assembly during plating operations. A lift/rotate actuator may be used to move the head to position a sector of the contact ring in a ring slot or opening of a deplating module. Since the deplating is performed within the deplating module, and not within the bowl assembly, the electroplating solution in the bowl assembly is not affected by the deplating process.
US08500967B2	Vacuum arc evaporation apparatus and method, and magnetic recording medium formed thereby In a vacuum are evaporation apparatus, to stably maintain vacuum arc discharge at an arc source when depositing a cathode material on a substrate, namely a magnetic recording medium, an ungrounded anode of a coil-type tube is placed inside an are source discharge vacuum chamber. A DC are power supply is connected between the cathode and the anode to cause an are current to flow in the anode to generate a first magnetic field in one direction, from the cathode toward the anode. A second magnetic field is generated in the opposite direction, from the anode to the cathode by feeding a specified current to an external coil positioned around the discharge chamber. The external coil includes an around-cathode coil and an around-anode coil. The arc discharge can be started by operating a striker to carry out the deposition.
US08500965B2	MSVD coating process The present invention is a method of coating a substrate in a single zone of a MSVD coater wherein the zone includes at least two bays, comprising running a first bay of a zone including a first target in metal mode and running the second bay including a second target in transition or oxide mode, wherein the ΔG of formation of the target oxide being run in transition mode or oxide mode is equal to or less than −160 kcal/mole O2 or the difference in ΔG between the target being run in transition mode or oxide mode and the target being run in metal mode is at least 60 kcal/mole O2.
US08500957B2	Enhanced method for monitoring the deposition of organic materials in a papermaking process A method for monitoring with enhanced sensitivity of the deposition of one or more organic materials dispersed in an aqueous medium in a papermaking process which includes measuring the rate of deposition of the organic materials from the aqueous medium onto a quartz crystal microbalance having a top side contacting with the aqueous medium coated with a layer containing a material with surface energy in the range from about 34 to about 49 dynes/cm2, and a second, bottom side isolated from the aqueous medium is disclosed. Additionally, a method for measuring the effectiveness of an inhibitor that decreases the deposition of the organic materials in a papermaking process is also disclosed.
US08500954B2	Method and apparatus for processing black liquor of pulp mill The invention relates to a method and apparatus for processing the black liquor of a pulp mill to recover the chemicals and energy therein. In the invention, the black liquor is pyrolyzed in a pyrolysis reactor (6), formed gaseous components are lead for utilization, sand is returned to a fluidized-bed boiler, and solid matter is mixed with water, whereby a soda-water solution is returned to the pulping process and solid carbon to the fluidized-bed boiler (1).
US08500953B2	Edge ring assembly with dielectric spacer ring An edge ring assembly surrounds a substrate support surface in a plasma etching chamber. The edge ring assembly comprises an edge ring and a dielectric spacer ring. The dielectric spacer ring, which surrounds the substrate support surface and which is surrounded by the edge ring in the radial direction, is configured to insulate the edge ring from the baseplate. Incorporation of the edge ring assembly around the substrate support surface can decrease the buildup of polymer at the underside and along the edge of a substrate and increase plasma etching uniformity of the substrate.
US08500948B2	PU adhesives for sterilizable composite films The invention relates to the use of a solvent-free, 2 component adhesive for adhering sterilizable composite films, wherein the adhesive comprises a component A made from at least one pre-polymer comprised of NCO groups, said pre-polymer produced from low molecular weight polyether alcohols, polyester alcohols and/or polyalkylene alcohols having a functionality of 2 or 3, implemented having a high molar excess of TDI and removal of the unimplemented monomer diisocyanate, and a component B comprising at least one 2 or 3 functional polyesterpolyol, produced from diols and/or triols on the basis of polyethers or polyalkylene diols implemented having dicarboxylic acids and derivatives thereof, wherein at least 10 to 40 wt % must be comprised of aliphatic C8 to C20 dicarboxylic acids, and auxiliary and additive materials in at least one component A or B.
US08500946B2	Fin seal container and method A method for assembling a fin seal container including folding a container blank into a three-dimensional body that defines an internal volume and includes an end portion that defines an opening into the internal volume, the end portion including a first fin seal panel having inner and outer major surfaces and a second fin seal panel having inner and outer major surfaces, folding the end portion such that the inner major surface of the first fin seal panel is positioned adjacent to the inner major surface of the second fin seal panel, separating the first fin seal panel from the second fin seal panel, treating the inner major surface of the first fin seal panel and/or the inner major surface of the second fin seal panel, and pressing the first fin seal panel into engagement with the second fin seal panel.
US08500945B2	Framing corner joint and method of manufacture A framing corner joint includes first and second framing rails of fiberglass-reinforced resin construction. The first and second framing rails have hollow mitered ends. A pair of thermoplastic plugs are received in the mitered ends of the respective framing rails. Each of the plugs includes a body inserted into the hollow interior of an associated framing rail and a flat plug flange at an angle of 45° to the body. The plug flanges extend outwardly from the peripheries of the bodies between the rail ends and have flat end faces that are bonded to each other. The bodies of the plugs preferably are hollow, and preferably are received by interference press-fit within the ends of the rails. The plug flanges of the plugs preferably are welded to each other.
US08500939B2	Manufacture of split tip catheters Multi-lumen catheter devices having at least one split-tipped end are disclosed, together with methods of forming such split tip catheters. In one aspect of the invention, the manufacturing methods can include the steps of: providing a catheter body having at least a first and a second internal lumen extending longitudinally through the catheter body; removing a distal portion of the catheter body to form a first distal tip segment such that the first lumen extends longitudinally within this tip segment beyond the second lumen; and joining a second lumen tip segment to the catheter body in communication with the second lumen. The second tip segment can be joined to the catheter body such that it is at least partially separated from the first tip segment and, in some embodiments, preferably diverges at an angle relative to the first tip segment.
US08500935B2	Method of making a tube using a cylinder air cooled heat welder A method of welding a thermoplastic sheet, having a first side and a second side, into a cylinder, the method comprising the steps of folding the thermoplastic sheet into a cylinder such that the first side and the second side overlap, positioning the thermoplastic sheet in a cylinder tube having a longitudinal opening such that the overlapping portions of the first and second sides of the thermoplastic sheet are aligned with the longitudinal opening, and activating a heat welder so that a press of the heat welder moves into the longitudinal opening of the cylinder tube and presses the thermoplastic sheet against an opposing surface to weld the overlapping portions of the first and second sides.
US08500929B2	Thermal processing method for improved machinability of titanium alloys A method is provided for improving the machinability of a titanium alloy includes heating the alloy at a temperature and time period that imparts to the alloy a microstructure having between about 10 and 15 vol. % alpha phase in a beta phase matrix. According to one embodiment, the alloy is thereafter annealed at a temperature lower than the temperature for the initial heating step, and for a duration that is longer than the time period for the initial heating step.
US08500924B2	High-strength steel plate and producing method therefor A high-strength steel plate includes the following composition: 0.18 to 0.23 mass % of C; 0.1 to 0.5 mass % of Si; 1.0 to 2.0 mass % of Mn; 0.020 mass % or less of P; 0.010 mass % or less of S; greater than 0.5 mass % and equal to or less than 3.0 mass % of Cu, 0.25 to 2.0 mass % of Ni; 0.003 to 0.10 mass % of Nb; 0.05 to 0.15 mass % of Al; 0.0003 to 0.0030 mass % of B; 0.006 mass % or less of N; and a balance composed of Fe and inevitable impurities. A weld crack sensitivity index Pcm of the high-strength steel plate is calculated by Pcm=[C]+[Si]/30+[Mn]/20+[Cu]/20+[Ni]/60+[Cr]/20+[Mo]/15+[V]/10+5[B], and is 0.39 mass % or less. The Ac3 transformation point is equal to or less than 850° C., the percentage value of a martensite structure is equal to or greater than 90%, the yield strength is equal to or greater than 1300 MPa, and the tensile strength is equal to or greater than 1400 MPa and equal to or less than 1650 MPa. If the tensile strength is less than 1550 MPa, the prior austenite grain size number Nγ satisfies the formula Nγ≧([TS]−1400)×0.006+7.0, and if the tensile strength is equal to or greater than 1550 MPa, the prior austenite grain size number Nγ satisfies the formula Nγ≧([TS]−1550)×0.01+7.9.
US08500922B2	Permanent magnet and process for producing permanent magnet The present invention relates to a permanent magnet manufactured by steps of: pulverizing a magnet raw material into fine particles having a grain size of 3 μm or less; mixing the pulverized magnet raw material with a rust preventive oil in which a high-melting metal element-containing organic compound or a precursor of a high-melting ceramic is dissolved, thereby preparing a slurry; compression molding the slurry to form a molded body; and sintering the molded body.
US08500921B2	Permanent magnet and manufacturing method thereof There are provided a permanent magnet and a manufacturing method thereof capable of densely sintering the entirety of the magnet without making a gap between a main phase and a grain boundary phase in the sintered magnet. To fine powder of milled neodymium magnet is added an organometallic compound solution containing an organometallic compound expressed with a structural formula of M-(OR)x (M represents V, Mo, Zr, Ta, Ti, W or Nb, R represents a substituent group consisting of a straight-chain or branched-chain hydrocarbon, x represents an arbitrary integer) so as to uniformly adhere the organometallic compound to particle surfaces of the neodymium magnet powder. Thereafter, desiccated magnet powder is held for several hours in hydrogen atmosphere at 200 through 900 degrees Celsius. Thereafter, the powdery calcined body calcined through the calcination process in hydrogen is held for several hours in vacuum atmosphere at 200 through 600 degrees Celsius for a dehydrogenation process.
US08500919B1	Portable washer for beverage containers The portable washer for beverage containers is a hand-carried device for providing clean coffee cups or other beverage containers to a social group where facilities with a large supply of clean containers may not be available. The portable washer includes a self-contained water supply and catch basin for used water, and internal electrical power to drive a plurality of rotary brushes for the mechanical scrubbing of containers. An electrically powered water heating element and water pump are also provided. The brushes are actuated by a pushrod switch extending up from the central rotary brush, the water pump and heater being powered by a separate master switch. Water is pumped through the tubular rotary brush supports to spray hot water from the brushes during washing operations. A removable splash guard and cover are provided. The cover has a carrying handle and external racks for the carriage of beverage containers.
US08500916B2	Method for aligning wafers within wafer processing equipment Systems and methods for aligning wafers within wafer processing equipment. In a first embodiment, a wafer alignment nozzle comprises a fixed cylindrical member. A moveable cylindrical member is disposed with the fixed cylindrical member in a sliding fit. The moveable cylindrical member comprises a plurality of angled fluid orifices for directing a plurality of streams of the fluid onto a surface of the wafer.
US08500914B2	Device for blowing off bottle bottoms With the device (1) according to the invention for blowing off impurities on bottle bottoms, in particular bottle inspection machines, a solution is to be created which makes it possible to achieve an optimum blow-off result at comparatively lower air volume flows. This is achieved according to the invention in that beneath the nozzle head (3) in the annular body (5) a channel (6) is provided, which is connected to a compressed air line (7), which in turn is linked to the compressed air feed line (9), wherein the channel (6) in the upper edge pointing to the nozzle head (3) forms an annular gap (14)—triggering the Venturi effect.
US08500908B2	Method and system for mask handling in high productivity chamber A structure for independently supporting a wafer and a mask in a processing chamber is provided. The structure includes a set of extensions for supporting the wafer and a set of extensions supporting the mask. The set of extensions for the wafer and the set of extensions for the mask enable independent movement of the wafer and the mask. In one embodiment, the extensions are affixed to an annular ring which is capable of moving in a vertical direction within the processing chamber. A processing chamber, a mask, and a method for combinatorially processing a substrate are also provided.
US08500907B2	Masking system for the masking of a cylinder bore The invention relates to a masking system for masking a cylinder bore (2) of a combustion engine (3) during a thermal coating procedure including a masking body (4) which can be placed during the thermal coating of a first cylinder (5) of the combustion engine (3) in the cylinder bore (2) of a second cylinder (7) to cover a cylinder wall (6) of the second cylinder (7). In this arrangement the masking body (4) is designed in such a way that a flow gap (10) of predeterminable breadth can be set between the masking body (4) and the cylinder wall (6) of the second cylinder (7) for the production of a flow (8) of a fluid (9).
US08500904B2	Gypsum-containing product The invention provides a set gypsum-containing product having increased resistance to permanent deformation and a method for preparing it comprising forming a mixture of a calcium sulfate material, water, and an appropriate amount of one or more enhancing materials chosen from condensed phosphoric acids, each of which comprises 2 or more phosphoric acid units; and salts or ions of condensed phosphates, each of which comprises 2 or more phosphate units. The mixture is then maintained under conditions sufficient for the calcium sulfate material to form a set gypsum material.
US08500902B2	Methods of making cementitious compositions and products made thereby A method of making cementitious particles using combustion synthesis is described. The method uses less energy and produces lower CO2 emissions than conventional processes. By controlling the process conditions, the morphology and the properties of the particles can be easily tuned for a variety of applications. A batch reactor and a continuous conveyor type reactor that can be used for the combustion synthesis with high viscosity raw materials are also described.
US08500901B2	Interference pigments The present invention relates to interference pigments based on coated flake-form substrates which are distinguished by the fact in that they comprise (A) a layer of SiO2 having a layer thickness of 5-350 nm, (B) a high-refractive-index coating having a refractive index n of >1.8 and/or (C) an interference system consisting of alternating high- and low-refractive-index layers and optionally (D) an outer protective layer, and to the use thereof in paints, coatings, automotive paints, powder coatings, printing inks, security printing inks, plastics, ceramic materials, glasses, paper, in toners for electrophotographic printing processes, in seed, in greenhouse sheeting and tent awnings, as absorbers in the laser marking of paper and plastics, in cosmetic formulations, for the preparation of pigment pastes with water, organic and/or aqueous solvents, and for the preparation of pigment preparations and dry preparations.
US08500899B2	Method for production of granulated polymer-asphalt binder and sulfur concrete with participation of sulfur polymer obtained in waste sulfur solvent—borne modification The method of production of granulated polymer-asphalt binder and sulphur concrete with the participation of sulfur polymer obtained through solvent-borne modification of waste sulfur at the temperature of 135-150° C. consists in composing this sulfur polymer with other ingredients. At the production of granulated polymer-asphalt binder the content of the sulfur polymer amounts to 40-60% by weight which, after heating to the temperature of 135-150° C., is mixed (mixer 2) with 20-40% by weight of waste phosphogypsum and after they are mixed, 15-20% by weight of D-50 road asphalt is dosed, which dissolves in this mixture reacting partly with the sulfur polymer. Next, this mixture is cooled to plastic form and granules of polymer-asphalt binder are formed in the extruder, which fall into 5% solution of silicone emulsion where they are cooled and covered with a layer of silicone emulsion. At the production of sulfur concrete at the temperature of 135-150° C., sulfur polymer in the amount of 25-35% by weight is mixed with waste phosphogypsum in the amount of 10-20% by weight (mixer 2); then the material flows downwards where it is mixed (mixer 1) with hot mineral material and waste slag from copper smelting. Liquid sulfur concrete, which is cooled and crushed into grains of 0-1 cm or poured into molds, is formed. The produced polymer-asphalt binder is used for making a binder course in road surfaces and for road repairs. The produced sulfur concrete is used for basic foundations in road surfaces.
US08500896B2	Solid ink compositions comprising amorphous esters of tartaric acid A solid ink composition comprising an amorphous component, a crystalline component, and optionally, a colorant, which are suitable for ink jet printing, including printing on coated paper substrates. In embodiments, the amorphous component is synthesized from an esterification reaction of tartaric acid.
US08500894B2	Wet scrubbing for removing particulate solids from oxygen supply line A method of mixing an oxygen gas with a hydrocarbon-containing gas includes the steps of wet scrubbing the oxygen gas in a wet scrubber, supplying oxygen gas from the wet scrubber to a gas mixer and mixing the oxygen gas with the hydrocarbon-containing gas in the gas mixer. Wet scrubbers for use in the method may take various forms, including packed-tower, bubble cap, and sparger-type wet scrubbers. The removal of the particulate matter reduces the risk of ignition of the hydrocarbon-containing gas in the gas mixer. The use of a wet scrubber in the oxygen supply line overcomes many problems currently faced with screen and filters, as per current practice.
US08500890B2	Air channel with integrated odor absorbing element An odor absorption component is fitted to a duct in a manner that does not obstruct fluid flow through the duct while simultaneously facilitating absorption of odors from a fluid flowing within the duct. The absorbing component comprises one or more carrier structures that support a fabric/textile treated with an odor absorption coating. In one position, the carrier structures can be placed on the wall of the duct such that a plane of the support structure is parallel to and in physical contact with the fluid flow within the duct. The carrier structures may also be placed in another position within the duct such that at least two surfaces of the carrier structure that extend in a longitudinal direction along its length are parallel to and in the path of the fluid flow within the duct.
US08500886B2	Apparatus for removing carbon dioxide from a gas Exhaust gas after coal or oil burning has moisture, which hinders carbon dioxide adsorption. It is necessary to completely remove this moisture with the minimum use of energy. The exhaust gas from the burning apparatus is first lowered of its temperature by passing through an total heat exchanger rotor, and the resultant gas which has low temperature and humidity is sent to a carbon dioxide adsorption rotor, thereby removing carbon dioxide from the gas, which is then sent through the total heat exchanger rotor with the resultant desorption of moisture adsorbed there and is exhausted to outside atmosphere, while the carbon dioxide adsorption rotor is desorbed of its carbon dioxide using water vapor, with the resultant very humid carbon dioxide to be sent to a processing system such as for underground burial.
US08500881B2	Carbon dioxide capture power generation system The present invention discloses a carbon dioxide capture power generation system provided with a boiler to combust a fuel in the oxygen atmosphere, a carbon dioxide capture equipment to remove carbon dioxide in the wake flow of the boiler, a piping branching from the wake flow of the boiler to recycle the combustion exhaust gas to the boiler, and a desulfurization equipment to remove sulfur oxides and a sulfuric acid removal equipment to remove a sulfuric acid gas in the upstream of carbon dioxide capture equipment and in the wake flow of the boiler.
US08500876B2	Automatic air dehydrator with offsite data management An air dehydrator system for supplying a source of dehydrated air includes an offsite data management system; at least one data network; and an air dehydrator located remote from the offsite data management system. The dehydrator includes a housing containing at least one drying canister; a pressurized air source; and a control circuit coupled with the pressurized air source. The control circuit is also in communication via the at least one data network with the offsite data management system. The control circuit controls operation of the pressurized air source dependent upon control by the offsite data management system.
US08500871B2	Water-vapor-permeable membrane, hollow-fiber membrane, and hollow-fiber membrane module A water vapor permeable membrane is provided comprising a dense layer and a support layer that are adjacent to each other, wherein the dense layer contains voids with a void length of 0.1 μm or less and the dense layer has a thickness of 0.1 μm or more and 2 μm or less while in the support layer, void (a), i.e. the void with the largest length in the 2 μm thick region measured from the boundary between the dense layer and the support layer into the support layer, has a length of 0.3 μm or more and void (b), i.e. the void with the largest length in the region ranging between 2 μm and 4 μm measured from the boundary into the support layer, has a length of 0.5 μm or more, the length of the void (b) being larger than that of the void (a). A water vapor permeable membrane having both a high water vapor permeability and a low air leakage is provided.
US08500868B2	Systems and methods for the separation of carbon dioxide and water Systems and methods for the separation and capture of carbon dioxide from water are generally described. In some embodiments, a vapor stream containing carbon dioxide and water is separated using a cascade of at least two flash drums. Additional flash steps may be incorporated to remove atmospheric gases, such as nitrogen and argon, from the feed. Carbon dioxide may be condensed and pressurized at purities suitable for pipeline transport and eventual storage in geological formations. In addition, water may be recovered at high purity.In some embodiments, fuel cells may be used in combination with fuel reforming or gasification to produce syngas. Certain aspects of the invention involve innovations related to the combined reforming and fuel cell process, that, in certain embodiments, do not depend upon water and carbon dioxide separation. It should be understood, however, that the invention is not limited to the applications described above, and may be used with any suitable system in which the separation of carbon dioxide and water is desired.
US08500867B2	CO2 absorption from gas mixtures using an aqueous solution of 4-amino-2,2,6,6-tetramethylpiperidine CO2 is absorbed from a gas mixture by bringing the gas mixture into contact with an absorbent that comprises water and at least one amine of the formula (I), wherein R1 and R2, independently of each other, are hydrogen or an alkyl group. According to the invention, absorption media comprise sulfolane or an ionic liquid in addition to water and an amine of the formula (1). A device according to the invention for removing CO2 from a gas mixture comprises an absorption unit, a desorption unit, and an absorption medium according to the invention that is conducted in the circuit.
US08500862B2	System and method for removing volatile vapors from containers A system is configured to remove volatile organic compounds from a container. The system includes an enclosed contactor vessel having a first inlet to receive vapor containing volatile organic compounds from the container and a second inlet. The second inlet receives a vapor capture medium from a source. A contactor facilitates entrainment of the volatile organic compounds with the vapor capture medium while a first outlet recirculates treated vapor back to the container to effect a closed loop.
US08500851B2	Multiple fixed-fluidized beds for contaminant removal The present disclosure relates generally to contaminant removal from gas streams. In certain embodiments, the present disclosure relates to a process for removing one or more contaminants from a gas stream via contact with a regenerable sorbent at high temperature and pressure, utilizing a unique arrangement of reactors operating in parallel.
US08500849B2	Reactive gas detection in complex backgrounds A differential absorption spectrum for a reactive gas in a gas mixture can be generated for sample absorption data by subtracting background absorption data set from the sample absorption data. The background absorption data can be characteristic of absorption characteristics of the background composition in a laser light scan range that includes a target wavelength. The differential absorption spectrum can be converted to a measured concentration of the reactive gas using calibration data. A determination can be made whether the background composition has substantially changed relative to the background absorption data, and new background absorption data can be used if the background composition has substantially changed. Related systems, apparatus, methods, and/or articles are also described.
US08500845B2	Process for refining lead bullion A unique pyrometallurgical lead refining process includes adding a Lewis acid component and an Arrhenius base compound to a molten lead bullion. The Lewis acid component and Arrhenius base compound are added in stoichiometric amounts that preferentially remove lighter amphoteric elements from the molten lead bullion, and promote reactions with amphoteric p-block elements in the lead bullion to form over the lead a slag of Lewis bases, thereby forming a slag layer incorporating the metal salts of the amphoteric p-block elements.
US08500841B2	Method of preparing keratin fertilizer with an additive of humic acids in colloid form and keratin fertilizer with humic acids additive A method of preparing a fertilizer by feather processing inserts a weighed feather into a reaction container, and then adds caustic potash. Water is then added, and feather disintegration occurs. Phosphoric acid is poured into the mixture, and then the pH is measured—and if necessary improved with phosphoric acid or caustic potash. Epsom salt, vitriol of iron, boric acid, manganic sulphate, zinc sulphate, cuprous sulphate, ammonium molybdate and calcium nitrate are mixed in, and the mixture is partitioned into transportation containers depending on the weight of caustic potash included in the mixture using a drain pump through appropriate filter under constant stirring. The mixture is diluted with water, and the whole mass is perfectly mixed. Humic acids are then mixed into the diluted mixture to form a final keratin fertilizer with humic acid additive in colloid form.
US08500837B2	Enhanced vane bundle design An enhanced vane bundle design that provides additional inlet chord area. An enhanced vane bundle for use in separator vessels includes top and bottom convexly-curved outlet baffles that extend horizontally from the outlet-side of the vane pack, the outlet baffles including a plurality of corresponding holes. The enhanced vane bundle further includes curved plates affixed to the convexly-curved outlet baffles, the curved plates and the convexly-curved outlet baffles define vertical pockets that extend vertically through an entirety of an outlet chord area on an outlet side of the enhanced vane bundle. The enhanced vane bundle further includes a plurality of tubes connecting the corresponding holes of the outlet baffles and extending vertically through the entirety of the outlet chord area.
US08500833B2	Abrasive article and method of forming An abrasive article including a material including an abrasive material and a filler material having an average negative coefficient of thermal expansion (CTE) within a range of temperatures between about 70 K to about 1500 K.
US08500826B2	Lipid-based wax compositions substantially free of fat bloom and methods of making Lipid-based wax compositions and their methods of making are provided for compositions substantially free of fat bloom. The compositions comprise approximately 7-80 percent by weight triacylglycerides and approximately 20-93 percent by weight monoacylglycerides and diacylglycerides combined. The methods comprise blending the monoacylglycerides, diacylglycerides, and triacylglycerides in the lipid-based wax composition by heating the lipid-based wax composition at a sufficiently high temperature to destroy substantially all crystal structure within the lipid-based wax composition. The methods further comprise pouring the lipid-based wax composition into a mold or a container having a surface and a core, wherein the pouring is conducted at a temperature at least 15° C. greater than the congeal point of the lipid-based wax composition. The methods further comprise cooling the lipid-based wax composition under conditions sufficient to cool the core to at least 5° C. below the congeal point of the lipid-based wax composition in approximately 30-90 minutes.
US08500825B2	Prosthetic foot with floating forefoot keel A prosthetic foot device has an elongate forefoot spring carried by a fastener and suspended between upper and lower bumpers. A heel spring is suspended between an end of the fastener and the lower bumper.
US08500820B2	Bone cement collector and method of use A bone cement collector includes a body having a structure that is permeable to bone cement and has opening for trapping bone cement. The body is releasably attached to an orthopaedic implant component at a location on the implant at which bone cement is likely to escape during positioning of the orthopaedic implant.
US08500819B2	Drug delivery and diagnostic system for orthopedic implants A drug delivery and diagnostic system can include an orthopedic implant having an outer attachment surface. A conduit can be coupled to the outer attachment surface. The conduit can have an inlet and a plurality of perforations formed along a length thereof. The conduit can be adapted to pass fluid between the inlet and the perforations. A subcutaneous port can be fluidly coupled to the inlet and be adapted to communicate fluid through the inlet, along the conduit and out of the perforations around and along the outer attachment surface of the orthopedic implant.
US08500818B2	Knee prosthesis assembly with ligament link A prosthetic knee joint assembly includes a femoral component and a bearing that supports articulation of the femoral component. The assembly further includes a tibial tray. Furthermore, the assembly includes a ligament link operably coupled to the tibial tray or the femoral component via a coupling component. The ligament link extending through the other of the tibial tray or the femoral component to couple to the respective one of the femur or tibia. The ligament link extends between first and second ends and includes an outer wall defining an interior longitudinal passage portion. First and second apertures extend through the wall. The first end extends through the first and second apertures and the longitudinal passage portion to define a first adjustable loop, and the second end extends through the first and second apertures and the longitudinal passage portion to define a second adjustable loop.
US08500815B2	Shoulder prosthesis with insert for locking screws An insert (1) designed for insertion into a central cavity (10) within the upper part of the prosthetic stem (13) of a shoulder prosthesis. The insert (1) is provided with at least one transverse hole (6) that is threaded or provided with an inner retaining rib or any other screw-locking means. The insert (1) is designed for locking of transverse tuberosity bone screws (4) in the same way as a cross-dowel-nut. The outer surface of the prosthetic stem (13) is provided with at least one transverse unthreaded hole (7) communicating with the central cavity (10) in order to allow a sliding passage for the bone screw (4).The insert for a prosthetic humeral head implant of an anatomical shoulder prosthesis is interchangeable with an insert for the cup-shaped humeral implant (18) of a reverse shoulder prosthesis. The insert (1) is provided with a fixation site (8) for a targeting arm.
US08500811B2	Device and method for delivery of multiple heterogenous orthopedic implants An orthopedic coupling device is used for simultaneous attachment of multiple heterogeneous orthopedic components, such as a spacer and plate, for implantation in the body. The device coupler includes a coupling base, at least one coupling member configured to attach to one an orthopedic spacer while also trapping or clamping an orthopedic fixation plate between the coupling base and the orthopedic spacer. The orthopedic coupler device may have a detachable handle to facilitate access and visibility of the spacer and plate after initial implantation.
US08500808B2	Artificial eardrum using silk protein and method of fabricating the same Provided is an artificial eardrum using silk protein and a method of fabricating the same. The artificial eardrum is fabricated in the form of a silk membrane by desalinating and drying silk protein (or silk fibroin) or a silk protein complex solution obtained after removal of sericin from a silkworm cocoon or silk fiber. Thus, regeneration of an eardrum perforated due to disease or a sudden accident is stimulated, a boundary of the regenerated eardrum is clean and biocompatibility and transparency are increased. In addition, the artificial eardrum may be fabricated using the silk protein or silk protein complex solution obtained from a silkworm cocoon alone or mixed with collagen, alginic acid, PEG or pluronic 127.
US08500806B1	Accommodating intraocular lens An intraocular lens has a polymeric optic defined by a harder posterior layer and a softer anterior layer. Haptics having a fulcrum attached to the posterior layer and a resistance arm attached to the anterior layer are provided. A bias is provided to the haptic to rotate the haptics about the fulcrum and cause the resistance arm to deform the softer anterior layer about the harder posterior layer to increase the optical power of the lens. As the haptic rotates, it axially displaces the optic anteriorly to additionally increase the optical power. The optical power is adjustable in response to stresses induced by the eye. The haptics are subject to a pre-bias that urges the haptics to rotate or bend about the fulcrum. Temporary restraints are provided to the haptics to retain a stressed shape of the lens against the bias during a post-implantation healing period.
US08500804B2	Ophthalmic sizing devices and methods An apparatus for sizing an intraocular lens and/or an ocular region of the eye of a subject, such as the anterior chamber, contains a sizing device and a measurement device. In one embodiment, the sizing device comprises a first leg having a first contact portion for operably engaging the ocular portion and a second leg having a second contact portion for operably engaging the ocular portion. The sizing device has a test geometry when placed within the ocular portion. The measurement device is adapted for determining a dimension of the sizing device based at least in part on the test geometry. The sizing device may also have a reference geometry when the sizing device in a reference condition. In certain embodiments, the difference between the reference geometry and the test geometry may be used for sizing the intraocular lens and/or the ocular portion.
US08500802B2	Two-piece prosthetic valves with snap-in connection and methods for use A prosthetic heart valve assembly includes a gasket member and a valve member including a plurality of fasteners and a plurality of engagement members corresponding to the fasteners. The fasteners and/or engagement members may be configured to guide the engagement members into engagement with the fasteners. For example, the fasteners may include U-shaped spring-biased clips, e.g., attached to a core or other portion of a sewing cuff of the gasket member, and the engagement members may include latches or barbed protrusions that engage one or more holes in the fasteners. During use, the gasket member is introduced into a tissue annulus, and secured to the annulus, e.g., using a plurality of clips directed through the sewing cuff. The valve member is then introduced into the annulus and the engagement members are snapped or otherwise guided into engagement with the fasteners to secure the valve member relative to the gasket member.
US08500801B2	Stents for prosthetic heart valves and methods of making same A single piece stent construction having a plurality of commissure posts, each of which extends upwardly from a solid ring along a bend line and generally along a central longitudinal axis of the stent.
US08500800B2	Implantation of repair chords in the heart Apparatus for use with at least one leaflet-engaging element, the apparatus including a delivery tool which includes an inner shaft, a surrounding shaft, and at least one leaflet-engaging element holder coupled to a portion of the surrounding shaft, the leaflet-engaging-element holder being shaped to define at least one coupling site for reversibly coupling the leaflet-engaging element to the tool. The surrounding shaft surrounds a portion of the inner shaft and is slidable along the inner shaft so as to position the leaflet-engaging holder in a vicinity of at least one leaflet of an atrioventricular valve of a patient. A distal end of the inner shaft is advanceable between leaflets of the atrioventricular valve and toward a tissue site of a ventricle of the patient. Other applications are also described.
US08500799B2	Prosthetic heart valves, support structures and systems and methods for implanting same Described herein are systems and methods for operation of a prosthetic valve support structure (32) having additional reinforcement coupled with panels (36). Multiple support members (620) are distributed across the inner surface of the valve support structure (32) at regular intervals. Each support member (620) can include a looped portion (621) to act as a hinge (52). Each looped portion (621) is in a location coincidental with the interlace between adjacent panels (36).
US08500798B2	Rapid deployment prosthetic heart valve A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment.
US08500797B2	Medical devices Medical devices and related methods are disclosed. In some embodiments, a method of manufacturing a medical device or a medical device component includes contacting a non-fluid first member and a second member, the first member comprising a first polymer and an alignable material different from the first polymer; aligning the alignable material; and bonding the first and second members together.
US08500794B2	Flexible stent The stent of the present invention combines a helical strut band interconnected by coil elements. This structure provides a combination of attributes that are desirable in a stent, such as, for example, substantial flexibility, stability in supporting a vessel lumen, cell size and radial strength. The structure of the stent of the present invention provides a predetermined geometric relationship between the helical strut band and interconnected coil elements in order to maintain connectivity at any diameter size state of the stent.
US08500792B2	Dual capture device for stent graft delivery system and method for capturing a stent graft A delivery system for delivering and deploying stents with proximal and distal apices includes a “guidewire lumen, a distal apex release lumen, a proximal apex release lumen, a distal apex capture device and a proximal apex capture device. The distal and proximal apex capture devices include a first distal capture portion and a second distal capture portion fixedly connected to the guidewire lumen and distal apex release lumen, respectively, and a first and second proximal capture portions, respectively. The first proximal capture portion is fixedly connected to the distal end of the apex release lumen and has fingers extending toward the first distal capture portion in a distal direction. The second proximal capture portion is fixedly connected to the distal end of the proximal apex release lumen and has fingers extending toward the second distal capture portion in a distal direction.
US08500788B2	Vascular stenting and other procedures Described herein are flexible implantable occluding devices that can, for example, navigate the tortuous vessels of the neurovasculature. The occluding devices can also conform to the shape of the tortuous vessels of the vasculature. In some embodiments, the occluding devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. Some embodiments describe methods and apparatus for adjusting, along a length of the device, the porosity of the occluding device. In some embodiments, the occluding devices allows adequate blood flow to be provided to adjacent structures such that those structures, whether they are branch vessels or oxygen-demanding tissues, are not deprived of the necessary blood flow.
US08500787B2	Radiopaque markers and medical devices comprising binary alloys of titanium There is disclosed medical devices, such as stents, guidewires and embolic filters, comprising a binary alloy of titanium and one binary element selected from platinum, palladium, rhodium, and gold. There is also disclosed a radiopaque marker comprising the disclosed binary alloy, as well as medical devices having the radiopaque marker attached thereto. Methods of attaching the radiopaque marker to the medical devices, such as by welding, are also disclosure also disclosed.
US08500783B2	Dynamic cervical plate with spacer Disclosed is a dynamic cervical plate system that may be adjusted to length, locked in place to provide compression, and will automatically shorten its length to maintain compression. The system includes spinal cages coupled to the plate which provide intervertebral spacers for excised discs. The cervical plate system has a flat elongated shaft adapted to span the intervertebral space and has at least two screw receivers spaced along the length of the plate. The screw receivers each have screw holes for accepting the heads of bone screws. The spinal cage is coupled to the plate and interposed between the screw receivers.
US08500782B2	Semi-dynamic fixation plate system A fixation plate system includes a plate with elongated slots, and first and second anchors for attaching the plate to vertebrae. The first and second anchors have different head configurations that are selected by the surgeon to control how settlement occurs at each fused segment. The head of the first fastener is insertable in any of the slots and resists translation. The head of the second fastener is insertable in any of the slots in free sliding engagement to allow translation of the head in that slot. In one method of use, the surgeon selects a segment where settling needs to be limited, and uses the first fastener to fix the plate near the segment and limit settling at that segment. The first and second fasteners have a built-in spring that assists in securing the fasteners in the plate.
US08500780B2	Dynamic linking element for a spinal attachment system, and spinal attachment system including said linking element A connecting element for a spinal fixing system that connects at least two implantable connection assemblies including a rod including a flexible part extended at one end at least by a rigid part, the flexible part including a cable at least partly surrounded by a polymer envelope, the cable including at least one elastic strand coaxial with the envelope.
US08500779B2	Minimally-invasive implant for opening and enlargement of processus spinosus interspace For minimally-invasive therapy for spinal canal stenosis, a therapeutic device capable of stationing an interspinous process spacer without the need of large skin incision or ligamentous tissue incision and also without the need of detaching of the paraspinal muscle from the spine. The interspinous process spacer includes a conoid screw region (2) to be screwed into a processus spinosus interspace; a spacer region (3) in the longitudinal direction of the screw region (2); head region (4) capable of free interlocking with a tool arbitrarily; and through-hole (5) passing through the axial centers of screw region (2), spacer region (3) and head region (4). The processus spinosus interspace is enlarged by screwing of the screw region (2) into the processus spinosus interspace. The spacer region (3) is pinched upon passing of the screw region (2) through the processus spinosus interspace to attain enlarging and fixing of adjacent processus spinosus interspaces.
US08500777B2	Methods for approximation and fastening of soft tissue Methods for approximating and fastening tissue by application of one or more tissue fasteners are provided. In one embodiment, spaced apart tissue locations are engaged by tissue penetrating members of a deformable fastener, one of more of the engaged tissue locations is moved toward another engaged tissue location to approximate the spaced apart locations, and the deformable fastener is deployed to secure the approximated tissue locations. These methods may be used in laparoscopic plication gastroplasty procedures for forming an invaginated tissue fold, to close holes in the gastrointestinal lumen, and in a variety of interventional procedures.
US08500776B2	Vacuum patch for rapid wound closure A surgical patch system for closing a wound includes a first surgical patch, a second surgical patch, a cord operably associated with the first and second surgical patches, and a port operably associated with the second surgical patch. The first surgical patch is positionable adjacent internal tissue of an underlying tissue site of an open wound. The second surgical patch is positionable adjacent external tissue relative to the underlying tissue site of the open wound. The external tissue is adjacent the internal tissue. The cord is configured and dimensioned to interconnect the first and second surgical patches. The port is positioned to enable the application of negative pressure to the open wound.
US08500773B2	Spring detach joint for delivering a detachable implantable device Methods and systems for delivering an implantable device to a target site, using a detachable link. The system can include an embolic coil mated to a delivery wire via a detachable link comprising first and second engaging members. When the detachable link is delivered through a catheter, the first and second engaging members are configured to self-detach.
US08500768B2	Apparatus for safe performance of transseptal technique and placement and positioning of an ablation catheter A steerable catheter system to perform a transseptal puncture procedure comprises a steerable catheter shaft with at least one inner lumen, and an inner element slidably positioned within a shaft lumen, wherein the distal tip of the shaft can be deflected, counter-deflected, rotated, and counter-rotated and wherein the inner element can be deployed or retracted. In one embodiment, a single steerable catheter is capable of performing an intended procedure and a transseptal procedure all in one, wherein the catheter comprises an outer steerable catheter and an inner element which can be deployed to perform a transseptal puncture, and wherein, once the inner element crosses the inter-atrial septum, the catheter itself can slide forward without advancement of the inner element.
US08500764B2	Rotational atherectomy device with fluid inflatable support elements supported by fluid bearings A rotational atherectomy device for removing a stenotic tissue from a vessel of a patient is disclosed. The device comprises a rotatable, flexible, hollow drive shaft having an open distal end. The drive shaft comprising a fluid impermeable wall, an abrasive element mounted to the drive shaft proximal to and spaced away from its distal end, the fluid impermeable wall being formed from a torque transmitting coil and at least one fluid impermeable membrane which define a lumen for the antegrade flow of pressurized fluid through the drive shaft and into a distal fluid inflatable support element to inflate said fluid inflatable support element. The distal fluid inflatable support element is located at the distal end of the drive shaft and has an outer wall comprising an outflow opening.
US08500762B2	Fixating means between a mesh and mesh deployment means especially useful for hernia repair surgeries and methods thereof The present invention provides a fixating means (200) adapted for use in hernia repair surgeries in attaching a mesh (2) and mesh deployment means (3); said fixating means are attached to said mesh deployment means (3); said fixating means (200) comprising: (a) a first portion (200a) coupled to said deployment means (3); and, (b) a second portion (200b), comprising a coil (252) having a predetermined retracted shape; said coil is reconfigurable from a plurality of unretracted positions to a plurality of retracted positions and from said plurality of retracted positions to said plurality of unretracted positions; wherein said attachment between said deployment means (3) and said mesh (2) is obtained by reconfiguration of said coil (252) from at least one of said unretracted positions to at least one of said retracted positions.
US08500755B2	Apparatus and method for delivering fasteners during valve replacement A fastener delivery tool includes a loading chamber for receiving a fastener having a pair of tines overlapping one another to define a loop in a parent or relaxed state. A retaining member retains the fastener in the loading chamber. The fastener delivery tool also includes a tongue, pusher member, and an ejection track communicating with the loading chamber. An actuator causes the tongue to move to engage the tines of the fastener to transform the fastener from the relaxed state to a constrained state defining a U-shape. The actuator also causes the pusher member to release the retaining member and advance the fastener down the ejection track in the constrained state. The tool also includes a trigger for ejecting the fastener completely from the ejection track. The fastener may be used to secure a prosthetic heart valve or components thereof into surrounding tissue, e.g., within a tissue annulus.
US08500743B2	Surgical jig A surgical jig for determining an axis extending into the end of a bone (2). The jig comprises a platform (10) arranged to be supported upon a resected surface (4) at an end of a bone (2), first and second clamps (16) and an alignment guide (18). The first and second clamps (16) are coupled to the platform (10) and are arranged to engage first and second portions of a bone lip (6) extending around at least part of the resected surface (4) to secure the platform (10) to the resected surface (4). The alignment guide (18) defines an axis extending into the end of the bone (2), the alignment guide (18) being pivotally coupled to the platform (10). A method of determining an axis extending into the end of a bone (2) using the surgical jig is also disclosed. The method comprises resecting the end of a bone (2) to leave a bone lip (6), coupling the surgical jig to the resected end of the bone (2), and pivoting the alignment guide (18) until the alignment guide (18) coincides with a required axis extending into the end of the bone (2).
US08500741B2	Pedicle screw extension alignment Alignment clamps, extension caps, and systems, with associated methods, for pedicle screw extension alignment in an orthopedic patient are described. An alignment clamp for alignment of pedicle screw extensions includes a clamp having a hollow interior. The clamp can receive a pedicle screw extension through the hollow interior. The clamp includes opposing open ends in communication with the hollow interior. A straightening rod receptacle is on a side of the clamp. The straightening rod receptacle is oriented to receive a straightening rod therethrough. The straightening rod receptacle can be substantially perpendicular to a direction of the clamp through which the pedicle screw extension is receivable.
US08500736B2	Treatment method for living tissue using energy A treatment method for a living tissue using energy includes a first step of outputting high-frequency energy to grasped living tissues to destroy cell membranes of the grasped living tissues, allowing proteins to flow out of cells and joining the living tissues to each other, and a second step of, after the first step, outputting heat energy to the grasped living tissues to dehydrate the grasped living tissues.
US08500735B2	Treatment method for living tissue using energy A treatment method for a living tissue using energy includes a first step of outputting energy to a grasped living tissue and raising a temperature of cells of the grasped living tissue, a second step of, after the first step, outputting high-frequency energy to the grasped living tissue and destroying cell membranes of the grasped living tissue to discharge proteins in the cells to the outside of the cells, and a third step of, after the second step, outputting heat energy to the living tissue and welding the proteins to each other while dehydrating the grasped living tissue.
US08500734B2	Cartilage treatment probe An electrosurgical instrument for ablating cartilage while limiting collateral damage includes a non-conducting head with a small electrically conductive surface. The head of the instrument is coupled to a shaft by a flexible portion. The flexible portion biases the electrically conductive surface towards a tissue surface. The head is pivotably coupled to the shaft such that the electrically conductive surface is oriented substantially parallel to the tissue surface as the head slides across the tissue surface. A method of performing electrosurgery includes positioning the electrically conductive surface adjacent to the tissue surface, and sliding the shaft across the tissue surface with the head pivoting such that the electrically conductive surface is oriented substantially parallel to the tissue surface.
US08500731B2	Adjustable length flexible polymer electrode catheter and method for ablation An ablation catheter includes a flexible elongated shaft having a flexible electrode at its distal end. The flexible electrode includes an inner, flexible, electrically-conductive element and an outer, flexible, electrically-conductive polymer layer in electrical contact with the inner, flexible, electrically-conductive element. The catheter further includes an electrically insulative sheath surrounding at least a portion of the flexible electrode and a linear displacement mechanism capable of adjusting at least one of the electrically insulative sheath and the flexible electrode to vary a length of the flexible electrode exposed at the distal end of the shaft. Also disclosed is an adjustable length ablation electrode and methods of ablating tissue.
US08500727B2	Methods, systems, and devices for performing electrosurgical procedures An electrosurgical system including a sharpened electrosurgical electrode, which can have a coated surface, and an automatically adjusting electrosurgical wave generator is disclosed. The automatically adjusting wave generator and the sharpened electrode tip provide or enhance the properties, attributes and/or characteristics of the electrosurgical system and prevent tissue damage and reduce incidences of post-operative complications, thereby quickening the healing process. The wave generator detects various circuit parameters and automatically adjusts the output settings, such as the output power level, based on the various circuit parameters, such as tissue impedance, to prevent undesirable tissue damage.
US08500722B2	Methods for compact counter balance arms In one embodiment of the invention, a method for a set-up arm of a robotic surgical system is disclosed. The method includes balancing a linkage structure with a balancing mechanism to support a load; moving the linkage structure varying a moment at a pivot point due to the load at the end of a link of the linkage structure; and changing a path length of one or more cables over a plurality of pulleys in the balancing mechanism to compress or decompress a spring to respectively increase or decrease tension in the one or more cables to balance the variance in the moment.
US08500718B2	System and method for locating fluid leaks at a drape of a reduced pressure delivery system A system and method for performing tissue therapy may include applying a reduced pressure to a tissue site of a patient. A fluid parameter associated with applying a reduced pressure to the tissue site may be sensed. An audible fluid leak location sound may be generated in response to sensing the fluid parameter. The audible fluid leak location sound may be altered in response to sensing that the fluid parameter changes. By altering the audible fluid leak location sound in response to sensing a change of the fluid parameter, a clinician may detect location of a fluid leak at the drape by applying force to the drape. The force applied to the drape may be a clinician pressing a finger onto an edge of the drape.
US08500715B2	Catheter connection hub Fluid communication to an end of a catheter is afforded through a connection hub selectively attachable thereto. The connection hub includes a catheter receiving element and a fluid coupling element that are relatively rotatable coaxially between a catheter receiving condition and a catheter capture condition of the connection hub. The catheter capture condition, a compressible sealing sleeve disposed interior of the connection hub between a pair of clamping jaws projecting from the catheter receiving element is urged into sealing engagement with the exterior of the catheter, catheter is gripped mechanically through the sealing sleeve by the clamping jaws. The exteriors of each of the catheter receiving element and the fluid coupling element are formed into planar actuation handles that facilitate relative rotation of the catheter receiving element and the fluid coupling element into coplanar alignment in the catheter capture condition of the connection hub.
US08500705B2	Apparatus for collection and analysis of human body fluids The present invention relates to the analysis apparatus capable of collecting the body fluid such as urine or blood, for embodiment urination and measuring or calculating the specific constituent from the collected body urine, and the apparatus for collecting body fluid capable of using by connecting to the analysis apparatus and its related article, in which the apparatus for collecting and analyzing for the body fluid of a patient consists of the body fluid collecting part and the collecting part case, the apparatus for collecting body fluid consists of the body fluid collecting part, the total tube and adapter, the collecting part is constructed with the absorbing tube, the sensor tube, the cleansing tube and the passage and is attachable/detachable connected to the collecting part, a diaper and pants exclusive for a patient are provided as the related article such that it is convenient to possess and has effects in the urination having no relations to the intention of a patient or in case of unable to use hand or foot by the intention, moreover in using together with a diaper and in nursing acute and chronic patient.
US08500700B2	Dosing unit, ambulatory infusion device comprising dosing unit and method for operating a dosing unit A dosing unit for an ambulatory infusion device and a method of operation are disclosed. The dosing unit includes a stationary member, a movable member, and a plunger. The movable member and the stationary member, together, make a charging valve and a discharging valve. The plunger is located, at least in part, in a metering cavity of the movable member and the movable member is adapted to selectively couple and decouple a driving unit, such that, by operating the driving unit with the movable member being coupled with the driving unit, the movable member moves with the plunger to maintain a position of the plunger relative to the movable member along a displacement axis, and by operating the driving unit with the movable member being decoupled from the driving unit, the plunger is displaced while the position of the movable member is maintained.
US08500698B2	Catheter anchor A catheter anchoring or securement device and system in combination with or for securing a catheter system to a patient's skin in a fixed position, the invention having a flexible anchor sheet member having an adhesive backing that adheres the flexible anchor sheet member to the patient's skin, a compressible catheter receiving pad mounted to the flexible anchor sheet member, and releasable securing strap covering the compressible catheter receiving pad, wherein the compressible catheter receiving pad is provided with a cavity or recess, the peripheral configuration of which corresponds to the footprint configuration of the catheter body member. The cavity has an axially-oriented channel extending the full width of the flexible anchor sheet member and opposing sets of retention walls defining lateral recesses, the combination of which precludes relative movement of the catheter fitting in all lateral directions.
US08500696B2	Method of producing indwelling needle assembly and indwelling needle assembly A method of producing an indwelling needle assembly formed by assembling an inner needle having a point only at its tip, an inner needle hub fixed to the base end of the inner needle, a hollow outer needle through which the inner needle is insertable, an outer needle hub fixed to the base end of the outer needle, and an elastic seal member on the outer needle hub effecting sealing when the inner needle is withdrawn. The method involves: inserting the inner needle into the seal member to set the inner needle to an inserted state; applying, in the inserted state, lubricant to the outer peripheral surface of at least that portion of the inner needle which protrudes from the seal member; and axially reciprocating at least one time the inner needle relative to the seal member to cause the lubricant to penetrate the inside of the seal member.
US08500692B2	Devices and methods for powering a medical device Devices and methods for powering a medical device for sustained delivery of fluids or continuous monitoring of body analyte. The devices may comprise a pumping mechanism, a driving mechanism for activating the pumping mechanism to dispense fluid, and a power source coupled to the driving mechanism and having an energy storage cell for providing a pulsed power to the driving mechanism. The methods may be implemented by activating the driving mechanism using pulsed energy in the form of at least one pulse train pattern accumulated in and discharged from an energy storage component.
US08500691B2	Method for producing a heating device having a heating profile for medical instruments and a heating device produced by that method A method for producing a temperature control means (5c, 5c) of an elastic heating profile (1), which heat and/or cool a medical instrument inserted into a cavity (3) of the heating profile (1), are provided in bores (4a, 4b, 4c, . . . ) having a bore diameter (110, 110′) which is smaller than the outer diameter (120, 120′) of the temperature control means (5c, 5e) to be inserted into the bores (4a, 4b, 4c, . . . ). A positive and/or non-positive connection between the heating profile (1) and the received temperature control means ensures good thermal contact. The production costs for an operable heating profile or temperature control means are also reduced.
US08500690B2	Passively shielding needle device A shieldable needle device includes a hub with and a needle cannula having a puncture tip extending from a forward end thereof, and a shield member in telescoping association with the hub. At least one of the hub and the shield member are adapted for relative axial movement with respect to the other between a first position in which the puncture tip of the needle cannula is exposed from a forward end of the shield member and a second position in which the puncture tip of the needle cannula is encompassed within the shield member. A drive member extends between the hub and the shield member, biasing the hub and the shield member axially away from each other. A packaging cover may further extend about the needle cannula, applying external pressure between the cooperating portions of the hub and the shield. In use, external pressure is applied by a user to at least one of the hub and the shield member providing an engagement therebetween, thus permitting removal of the packaging cover and preventing the drive member from biasing the hub and the shield member axially away from each other until activation is desired.
US08500689B2	Device for cannulation of a hollow organ There is disclosed a device for cannulation of a hollow organ, in particular of an arterial or venous blood vessel of a mammalian body, e.g., human, said device comprising a cannula that has a proximal end, a distal end, and a central section located between the proximal end and distal end. The distal end has an expandable structure which can be converted, for example by means of a dilator, from a non-expanded state to an expanded state, and the expandable structure comprises openings at least in the expanded state.
US08500686B2	Treating heart tissue Some embodiments of a system or method for treating heart tissue can include a catheter device that provides a user with the ability to perform a number of heart treatment tasks (before, during, and after a cardiac surgery or a percutaneous coronary intervention). In particular embodiments, the catheter device can be used to (i) precondition heart muscle tissue before the heart is isolated from the circulatory system, (ii) deliver cardioplegia into the coronary sinus during the cardiac surgery when the heart is isolated from the circulatory system, and (iii) control the blood flow through the heart after the heart is reconnected with the circulatory system. In some embodiments, the catheter device can perform some or all of: (i) intermittently occluding the coronary sinus, (ii) delivering a treatment fluid into the coronary sinus, and (iii) monitoring a flow rate of blood passing from the coronary sinus to the right atrium.
US08500681B2	Injection systems The invention in general relates to various injection systems and devices that can be used, for example, in needleless injection systems for human, and for domestic and farm animals. In certain embodiments, the invention provides an injection system comprising: an injector defining a first cavity in fluid communication with an orifice configured for needleless injection; a housing defining a second cavity, the housing different than the injector; a first movable member between the first cavity and the second cavity, wherein the first movable member is configured to transfer a fluid from the second cavity to the first cavity; and wherein the first movable member is configured to be substantially stationary until the first movable member is moved by a propellant.
US08500679B2	Huggable breastpump A soft carrier for a breastpump is disclosed. The carrier includes a cushion made of a soft, malleable outer material, for at least partially enclosing a breastpump and associated accessories. One or more breast shields extend outwardly from holes in the cushion. The soft carrier provides a more comfortable experience for the mother during pumping.
US08500671B2	Device for extracorporeal blood treatment in single-needle operation mode A device for the extracorporal blood treatment in a single-needle operating mode includes means for delivering blood into, and means for delivering blood out of means for collecting blood, and a controller for setting the respective delivery rates of the means for the delivery of blood. The operating mode of the means for delivering blood is continually switched between an arterial and a venous phase by the controller, wherein during the arterial phase the delivery rate Qb of the means for delivering blood is greater than the delivery rate Qsn of the means for delivering blood such that blood may be withdrawn from the patient during the arterial phase, and during the venous phase the delivery rate Qb is smaller than the delivery rate Qsn such that blood may be administered to the patient during the venous phase.
US08500670B2	Post-operative vest The invention relates to a variable tension chest support for use by patients having undergone thoracic surgery. The chest support may be worn directly on the skin of a patient and comprises a band of stretchable material and one or more grips which are wholly or partially concealed within pockets with which the patient may alter the tension of the chest encircling band. The device allows a patient to modify the level of tension applied to the chest, thus managing the recovery process, while providing a basic level of support at all times the support is in use.
US08500668B2	Orthosis and method of use for treatment and rehabilitation of dropfoot A functional electrical stimulation brace responsive to various positions of an intended wearer's foot. The device includes a plurality of sensors positioned at different locations under the intended wearer's foot to detect the current position of the foot. Outputs from the sensors are fed to a controller that uses logic to activate an electrical stimulation unit that stimulates the peroneal muscles of a patient at the appropriate times during the patient's gait. The device may also employ mechanical stabilization of the ankle in addition to the functional electrical stimulation by means of an ankle foot orthosis with a variable resistance hinge. The electrodes are embedded in fixed locations in the brace upper portion so that optimal location of the electrodes relative to the peroneal muscles is maintained every time the device is applied. Also provided is a method for assistance and rehabilitation for a patient by electrical stimulation of the peroneal muscles. In the method, the position of the foot is detected and the peroneal muscles are stimulated responsive to particular positions of the patient's foot in order to activate the muscles at the appropriate times during the patient's gait. The device also provides lateral and torsional stability by means of the ankle-foot orthosis.
US08500667B2	Crevice collar A device for treatment of limbs affected with Lymphedema. The device is a crevice collar which fits into depressed areas and crevices created by over-hanging lobules and protrusions of tissue so that the tissue may be comfortably wrapped with a pressure wrap with exacerbating sores and crevice areas in the skin caused by the Lymphedema.
US08500666B2	Massage device A therapeutic massage device, specifically a manual scalp massager that can both provide a soothing sensation to the user and also stimulate the sebaceous glands and hair follicles of a person's scalp, resulting in a healthier scalp and better looking hair. The device should efficiently, and without harm or discomfort to the user, be able to pinch the tightly drawn scalp of the user, thereby squeezing the sebaceous glands and improving oil production. The device should also be easy to use and should not require an inordinate amount of effort by the operator. In operation, the device can massage one's scalp by alternating between constricting and releasing the skin.
US08500665B2	Instrument for applying vibrations to the human body An instrument for applying vibrations to the human body is disclosed, comprising a housing in which an axially movable ram is arranged at the distal end, and a drive device for the ram, for setting the ram in a reciprocating motion, wherein the drive device comprises an axially movable projectile arranged proximally of the ram and an accelerating device for the projectile for accelerating the projectile distally in the direction of the ram, the ram being able to execute a stroke of at least 1 mm.
US08500664B2	Massage chair with foot massaging device A massage chair with a foot massaging device, which includes a seat unit, a backrest unit, and the foot massaging device located at a front portion of the seat unit, can make the structure simpler, the weight lighter, and the cost lower all at once. The massage chair is provided under the seat unit 2 with a back-and-forth motion mechanism 15 joined to the foot massaging device 5, and when the back-and-forth motion mechanism 15 protrudes forward, the foot massaging device 5 advances to a using position U which is located in front of the seat unit 2 and at which a lower leg of a user can be massaged, while when the back-and-forth motion mechanism 15 retracts backward, the foot massaging device 5 is housed in a housing position P formed under the seat unit 2.
US08500663B2	Vibrating massage roller utilizing a plurality of supports and eccentric weights The present invention is a vibrational roller utilizing a motorized vibrational drive using a plurality of eccentric weights and associated supports. The weights are positioned along the axis of rotation in a manner to synchronize them and minimize vibrational dissipation throughout the roller. Each weight has at least one associated support. The supports then transmit vibrational forces to the surface of the roller in an evenly distributed manner. A second co-operational motor may be used to extend motor life and aid in initiating vibrations. A control panel and associated circuitry are utilized to alter vibrational characteristics. The roller may be battery powered or powered through a standard wall outlet. The roller itself is manufactured of a durable yet deformable material, such as foam rubber, and may be inserted into selectable sleeves of varying physical properties for desired effect.
US08500661B2	Apparatus and method of body contouring and skin conditioning The present invention provides an apparatus and method of body contouring and skin conditioning. The apparatus 10 treats cellulite and the like by producing vibrations in the subcutaneous layers of fat. A cup 18 of handpiece 16 is placed against the skin to create a chamber 60. A vacuum source 160 and compressor 162, which are in communication with chamber 60, are then controlled to produce an oscillating pressure within the chamber 60. This vibration of the skin surface is transferred through the dermal layers thereby influencing fluid retention and cellulite build up.
US08500660B2	Device for monitoring size of luminal cavity A system for measuring the size of a gastric lumen includes a gastric banding device, an antenna positioned outside of the patient's body, and a receiver in operative communication with the antenna. The banding device comprises two orthogonal ultrasonic transceiver modules, a microprocessor, and a transmitter in electrical communication with the microprocessor. The microprocessor is in operative communication with each of the two transceiver modules. The transmitter transmits signals to a receiver positioned outside of a patient's body. Another system for measuring the size of a gastric lumen includes a gastric banding device having a first coiled conductor. The system further comprises a circuit external to the banding device, the circuit comprising a second coiled conductor. The circuit further comprises a tunable frequency generator and a spectrum analyzer, the circuit being tunable to allow a resonant frequency.
US08500656B2	Guide wire for use with a catheter A guide wire (1) for use with a catheter comprises a core wire (3) terminating in a distal portion (18) of flat ribbon-like construction having respective opposite major surfaces (29,30). A spring (24) is brazed to a distal end (27) of the distal portion (18) and to the core wire (3) at a tapering portion (14). A reinforcing member (38) extends axially along the distal portion (18) from a proximal end (26) of the distal portion (18) to a location (40) for reinforcing the distal portion (18) for in turn increasing its torsional rigidity in order to minimize axial twisting of the distal portion (18). A guide portion (42) of the distal portion (18) between the location (40) and the distal end (27) is provided to be bent at a desired set curved configuration for offsetting a distal tip (9) of the guide wire (1) from a central axis (8) thereof, so that by rotating the guide wire (1) at its proximal end (5) the distal portion (18) is also rotated for aligning the distal tip (9) with a branched vessel into which it is desired to direct and urge the guide wire (1).
US08500653B2	Neurophysiology monitoring system configured for rapid stimulation threshold acquisition The present invention relates generally to systems and algorithms aimed at neurophysiology monitoring, and more particularly to a system capable of quickly finding stimulation thresholds over multiple channels of a neurophysiology monitoring system. For example, the neurophysiology monitoring system may be configured to omit stimulation pulses when the neuromuscular response is predictable.
US08500652B2	System for intra-operative stimulation including visual indication of absence of delivery of stimulation signal Improved assemblies, systems, and methods provide safeguarding against tissue injury during surgical procedures and/or identify nerve damage occurring prior to surgery and/or verify range of motion or attributes of muscle contraction during reconstructive surgery. A stimulation control device may incorporate a range of low and high intensity stimulation to provide a stimulation and evaluation of both nerves and muscles. A stimulation control device is removably coupled to a surgical device or is imbedded within the medical device to provide a stimulation and treatment medical device. A disposable hand held stimulation system includes an operative element extending from the housing, the housing includes a visual indication to provide feedback or status to the user.
US08500649B2	Blood pressure measuring apparatus and method for measuring blood vessel elasticity A blood pressure measuring method which can measure blood vessel elasticity, so that that the blood vessel elasticity can be commonly applied to all subjects, calculating pulse transit time at the time when no pressure is applied, calculating pulse transit time in an area where the pressure is changed by the cuff, and then calculating the elasticity of a blood vessel, using the pulse transit times.
US08500644B2	Applying renyi entropy to detect changes in scattering architecture A method for imaging a region of interest (ROI) within a body. The method includes applying ultrasound energy to the ROI, receiving ultrasound data for the ROI in response to the applied ultrasound energy, executing a moving window analysis on the received ultrasound data to generate a plurality of windows of information, applying a Renyi entropy signal receiver to each of the generated windows to generate Renyi entropy data, and presenting an image of the ROI based on the Renyi entropy data.
US08500642B2	Ultrasonic treatment apparatus with a protective cover An ultrasonic treatment apparatus comprised of: a patient support for supporting a patient, an ultrasound transducer system for ultrasonic treatment of the patient, a region formed in the patient support operable for transmitting ultrasound from the ultrasound transducer system to a treatment zone in the patient, a protective cover for covering the region, and wherein the protective cover is adapted to be removed from the region while the patient is positioned relative to the treatment zone such that the treatment zone is able to receive treatment from the ultrasound transducer system.
US08500639B2	Systems and methods for shear wave field formation An ultrasound imaging system provides dynamic control of a shear wave front used to image viscoelasticity in a biological tissue. The system receives an indication of a region of interest and selects a shear wave front shape. The system also selects, based on the selected shear wave front shape, focus locations for a plurality of push pulses and a sequence for moving a shear wave source among the focus locations. The system transmits a series of push pulses according to the selected sequence, and determines a speed of the shear wave front as it passes through the region of interest. Changes in the speed of the shear wave front are related to changes in stiffness within the tissue.
US08500638B2	Non-contact ultrasonic tonometer A non-contact ultrasonic tonometer for measuring an intraocular pressure of an examinee's eye in non-contact manner by use of an ultrasonic wave, comprises: an ultrasonic transducer including a transmitter which emits an ultrasonic transmission pulse wave to the eye and a receiver which detects an ultrasonic reflection pulse wave from the eye, the transducer being arranged to be placed in a position apart from the eye and to transmit and receive the pulse wave with respect to the eye through the medium of air; and a calculation part being arranged to obtain a peak amplitude level of the reflection pulse wave based on an output signal from the ultrasonic transducer and measure the intraocular pressure based on the obtained peak amplitude level.
US08500637B2	Viscosimetric biosensor for monitoring analyte levels The invention relates to a viscosimetric sensor for monitoring an analyte level in a patient or in body fluids ex vivo. In particular, the invention relates to a sensor for monitoring analytes, such as glucose levels in a patient. The sensor comprises at least two hermetically closed chambers (2a, 2b), including an activation chamber and a measuring chamber, containing a sensitive fluid (3), the chambers communicating with each other through at least one microchannel (5), and a semi-permeable barrier (4) allowing the analyte to enter or leave the chambers. Each said chamber comprises at least one flexible membrane (6, 7) configured for antagonistic variations of the volume of the chambers.
US08500634B2	Surgical access system and related methods A surgical access system including a tissue distraction assembly and a tissue refraction assembly, both of which may be equipped with one or more electrodes for use in detecting the existence of (and optionally the distance and/or direction to) neural structures before, during, and after the establishment of an operative corridor to a surgical target site.
US08500631B2	Methods and devices for percutaneous illumination Methods and devices for illuminating a body cavity or an internal region of a body are disclosed. In one aspect, a percutaneous illumination device for illuminating a body cavity includes an elongate member with an illumination source, and two support members disposed on the elongate member that are adapted to be positioned on opposite sides of a tissue surface for stabilizing the device. Variations on such an illumination device, kits that include such devices, and methods of utilizing such devices are all described within the present application.
US08500624B2	Systems and methods for sling delivery and placement The present invention provides devices and methods for delivering an implantable sling to an anatomical location in a patient.
US08500622B2	Ventricular function assisting device and a method and apparatus for implanting it The present invention provides a ventricular function assisting device configured to be implanted in a heart ventricle designed in a form of flower-like configuration comprising two or more petals attached at a base section, said petals comprise elastic elements and/or portions capable of being elastically bent in radial directions and optionally also in sideway and/or longitudinal directions, which allow changing the state of the device between: i) a folded conformation, in which its petals are radially pressed inwardly towards each other to assume a reduced diameter of its flower-like configuration; and ii) a deployed conformation, in which the petals are opened in a radial outward direction as the device is discharged from the delivery tube or sheath into a heart ventricle and implanted thereinside in a preloaded state.
US08500620B2	Ventricular assist device A manifold for accessing blood from a human blood vessel is disclosed which comprises a first and a second pathway intersecting with each other at an angle, the first pathway being configured to be completed embedded in the human blood vessel with the second pathway leading toward outside of the human blood vessel wherein the manifold is substantially retained by the human blood vessel alone.
US08500616B2	Toner mass control by surface roughness and voids The present disclosure relates to controlling a performance characteristic of an image forming device component having a surface which may include removal of a portion of the surface to expose a plurality of voids and a surface between the voids. The surface between the voids may have a surface roughness Ra in the range of 0.1 to 5.0 microns and the relationship SAV/(SAV+SAC) is equal to 1-50%, where SAV is the surface area of the voids and SAC is the remaining surface area of the component. The performance characteristic may include the control of toner mass conveyed and/or toner filming and/or the amount of residual toner removed from a photoconductive surface.
US08500615B2	Magnetic roller and manufacturing method thereof, developer carrier, development device, processing cartridge, and image forming apparatus A magnetic roller includes a solid-core roller having magnetic anisotropy in a direction orthogonal to a central axis thereof. The solid-core roller includes a body part, and shaft parts disposed on both ends of the body part, a concave groove provided in an outer circumference face of the body part to extend in an axial direction, and a magnetic block disposed in the concave groove, the magnetic block having a direction of magnetic anisotropy substantially orthogonal to a direction of the magnetic anisotropy of the magnetic roller.
US08500614B2	Pilates reformer exercise machine A reformer includes a combined mount that serves to attach and support a foot bar assembly, a jump board, and a spring bar. The combined mount is easily and quickly attached to a side rail of a frame of the reformer. A carriage of the reformer includes a combined wheel axle and strap attachment point, which eliminates the need for a separate strap attachment bracket. The carriage also include side wheels which are mounted on the sides of the carriage, and which are biased outward so that they contact the side rails of the frame of the reformer.
US08500613B2	Portable leg exerciser and mobility enhancement system A system (100) and method (400, 500) to exercise the leg and enhance mobility after a variety of injuries or surgery is disclosed. The system could include a chair leg anchor (104), a leg wrap (102), a stationary pulley (110) secured to the chair leg anchor, a movable pulley (108) secured to the leg wrap, a rope (106), and a handle (112). The rope could be threaded from a first end secured to the chair leg anchor, through the movable pulley, through the stationary pulley, and to a second end secured to the handle.
US08500610B2	Exercise device An exercise device for allowing a user to obtain a full body workout includes an innermost tubular member and an outermost tubular member, the tubular members fitted together and longitudinally and slidably movable in a telescoping manner relative to each other during the workout, a chamber within the outermost tubular member, the chamber receiving a compressible gas that provides resistance to relative movement of the tubular members, a collar between the innermost tubular member and the outermost tubular member, a lower limb connector attachment mounted to an end of one of the innermost or outermost tubular members for attachment to a lower limb of a user, and a gripping area at or near an opposite end of the other of the innermost and outermost tubular members to the lower limb connector attachment to stretch and strengthen the user's body muscles during the workout.
US08500608B1	Exercise apparatus comprising a slidable weight bar assembly with hand brake assemblies Exercise apparatus having a slidable weight bar assembly with hand brake assemblies is provided for enaging and disengaging the weight bar assembly with a support frame. The exercise apparatus can be configured as a squat machine or a bench press. The exercise apparatus can include an adjustable back support that facilitates proper positioning and support of the operator's upper and lower back while performing squat exercises. The exercise apparatus can further include spring assemblies that increase the kinetic load during downward movements of the slidable weight bar assembly.
US08500605B2	Apparatus and method for temporary mounting of a hangboard An assembly for mounting of a hangboard includes first and second brackets each having first and second opposing end regions and a first elongate member having first and second spaced apart connection points configured for attachment to the first end regions of the first and second brackets. A second elongate member has third and fourth spaced apart connection points configured for simultaneous attachment to the first and second brackets. The second elongate member has a third connection point configured for attachment at a point along a portion of the first bracket between the first and second end regions thereof; and the fourth connection point configured for attachment at a point along a portion of the second bracket between the first and second end regions thereof. When the first and second members are so attached the assembly can be suspended within a wall opening.
US08500601B2	Method for the operation of a transmission device of a vehicle drive train A method of operating a transmission of a vehicle drive train with at least one drive machine. The transmission is formed with at least one interlocking shift element and a plurality of frictional shift elements in order to obtain various gear ratios. During an engaging process of the interlocking shift element, starting from a disengaged operating condition, in which halves of the interlocking shift element are out of engagement, to an engaged operating condition, in which the shift element halves are interlocked in a rotationally fixed manner, when interlock between the shift element halves is obstructed, a rotational speed difference is produced at least temporarily between the shift element halves, at which the interlock in the area of the interlocking shift element can be engaged. To produce the speed difference between the shift element halves, the transmission capacity of at least one frictional shift element is increased.
US08500596B2	Vehicle drive force distributing apparatus A vehicle drive force distributing apparatus includes an irreversible transmission mechanism, an operating state determining component and a command value resolution switching component. The irreversible transmission mechanism prevents a radially oriented pressing force, generated between first and second rollers based on an inter-roller radial pressing force command value, from decreasing during a period while command value is constant to maintain the radially oriented pressing force at a prescribed value without operating an inter-roller radial pressing force generating source. The operating state determining component determines whether first or second vehicle operating states exists during which a first or a lower second precision level of drive force distribution control, respectively, is to occur between main and subordinate drive wheels. The command value resolution switching component provides the inter-roller radial pressing force command value at a constant value for a longer period during the second vehicle operating state.
US08500593B2	Twin variator transmission arrangement A transmission arrangement is disclosed which comprises first and second variators (166, 169) each of which comprises an input race (150, 154) and an output race (152, 156). A plurality of rollers (276, 278) is arranged to run upon the input and output races to transfer drive from one to the other. The races are mounted for rotation about a common axis and the inclination of the first variator's rollers is variable independently of the inclination of the second variator's rollers, so that the two rollers are able to provide independently and continuously variable drive ratios. To provide traction between the rollers and races, a biasing device (216, 217) applies an axial force to one of the races, urging the rollers and races into engagement with each other. Each variator is provided with a shunt gear for providing forward, reverse and g eared neutral ratios, and to couple the variator input to the shunt gear a coupling member (160) passes through the outer variator races.
US08500592B2	Speed reducer, robot hand and robot Through holes are formed in a revolving gear which revolves while being engaged with a ring gear, and penetration pins which are configured to extract rotation of the revolving gear are inserted in the through holes. The ring gear and the revolving gear are divided into halves in the thickness direction. Two sheets of ring gears are biased to rotate in reverse directions.
US08500590B2	Electromagnetic clutch disconnect for accessory drive An automotive accessory drive system for a motor vehicle connects to an internal combustion engine crankshaft during at least one mode of operation. The system includes an accessory drive pulley, a starter motor/generator, and an endless loop power transmission member connecting at least the starter motor/generator and the accessory drive pulley. A planetary gear set includes a sun gear, a ring gear integrally associated with the accessory drive pulley, and a planetary carrier connected to the engine crankshaft. First and second one way clutches connect the engine crankshaft to the ring gear, and the sun gear to a grounding member, respectively, to define a normal drive mode and an engine start mode, respectively. An electromagnetic disconnect includes a normally closed friction clutch connecting the grounding member to ground to define a third mode of operation corresponding to a free wheel function with the grounding member disengaged from connection to ground.
US08500588B2	Automatic transmission gear and clutch arrangement A transmission is provided having an input member, an output member, four planetary gear sets, a plurality of coupling members and a plurality of torque-transmitting devices. Further, a hydraulic fluid control circuit is provided for controlling the operation of the plurality of torque-transmitting devices. The hydraulic fluid control circuit receives pressurized hydraulic fluid from a hydraulic fluid pump and has a plurality of fluid passages disposed in the transmission housing, input member and other coupling members.
US08500587B2	Multiple-variator control for split power CVT and hydrostatic transmissions A system for providing hydraulic power in a machine transmission includes a first hydraulic variator and a second hydraulic variator, each variator having a mechanical input to a hydraulic pump, and a hydraulic motor linked to the hydraulic pump via a hydraulic circuit, and a mechanical output from the hydraulic motor. In an embodiment, the first hydraulic circuit side of one variator is hydraulically connected to the first hydraulic side of the other variator, and the second hydraulic circuit sides are likewise linked together. A common input is geared to the inputs of the variators and a common output is geared to the outputs of the variators, tying the pump and motor of each variator to rotate at the same speed as the counterpart components of the other variator.
US08500585B2	Power transmission system of hybrid electric vehicle A power transmission system of a hybrid electric vehicle may include an input shaft, a first planetary gear set having a third rotation element fixedly connected to the input shaft and a second rotation element fixedly connected to a first motor/generator, a second planetary gear set having a fourth rotation element selectively connected to the second rotation element, a fifth rotation element directly connected to the first rotation element, and a sixth rotation element fixedly connected to a second motor/generator, an output gear connected to the fifth rotation element, a first clutch selectively connecting the second rotation element with the fourth rotation element, a second clutch adapted to selectively connect the third rotation element with the second motor/generator, a first brake interposed between the fourth rotation element and a transmission housing, and a second brake interposed between the sixth rotation element and the transmission housing.
US08500583B2	Aircraft starter generator A starter generator has an electric rotating machine having a rotating shaft and designed to carry two reverse operations—motor and generator. A first clutch is connected between the rotating machine and the first rotating shaft for transmitting rotations of the rotating machine to the first rotating shaft. A second clutch is connected between the rotating machine and the second rotating shaft for transmitting rotations of the second rotating shaft to the rotating machine. A continuously variable transmission is provided for changing the number of rotations transmitted from the second rotating shaft to the rotating machine. The rotating machine is supplied with electric power to rotate the rotating shaft, or the number of rotations of the rotating shaft is kept constant by controlling a transmission ratio of the continuously variable transmission.
US08500581B2	Multiple sprocket assembly for bicycle A multiple sprocket assembly includes a number of sprockets attached to a hub of a bicycle frame, and a rear chain transfer device having a carrier slidably attached to the bicycle frame and movable relative to an image plane formed by addendum of the teeth of the sprockets for engaging with a chain and for carrying and moving the chain onto the teeth of the sprockets, the rear chain transfer device includes a support attached to the bicycle frame, and a sliding member slidably attached to the support, and the carrier is attached to the sliding member for engaging with the chain and for carrying and moving the chain onto the teeth of the sprockets, an actuating device moves the sliding member relative to the support.
US08500577B2	Lacrosse stick pocket and related method of manufacture A lacrosse head pocket includes an elongated single layer runner with multiple cross pieces. The single layer runner can be constructed from a material, such as a polymeric material, molded over the cross pieces. The cross pieces and/or runner can include speed lace loops with which a net lace can be joined. A related method includes providing cross pieces, overmolding a polymeric material over the cross pieces to form a single layer runner, where the overmolded material is the only structure extending between and connecting the cross pieces, and where the cross pieces are transverse to the runners. Another method includes providing a pocket base overmolding the base with a polymeric material to cover portions of it, and forming connection elements between different portions independently of any other components of the pocket base.
US08500576B2	Waist-mounted tethered ball and target A game device has a target plate fixed to the waist area of a person who will play the game, and a ball is tethered to the target plate. The tether is flexible to allow the ball to engage a target on the target plate. To facilitate control of the ball on the tether, the tether has a rigid rod flexibly fixed to the bottom of the target plate, and a flexible string extending from the rod to the ball. There are sights between the targets on the target plate. By swinging the tethered ball with the tether aligned with a sight, the player can align the ball to be received by a target. Baskets in the targets catch the ball, so the ball can be easily removed from the target. Electronic play instructions, electronically directed game play, electronic scorekeeping means, and electronically directed alternative player goals are provided.
US08500571B2	Side locking adjustable shaft connection systems for removably connecting a golf club head and shaft Releasable golf club head/shaft connection systems and methods allow one to change shafts on a single club head, change club heads on a single shaft, and/or change the angular orientation features of a golf club. Such systems may include: (a) a club head body including a hosel and a locking nut stabilizer; (b) a shaft releasably engaged with the club head body, wherein an end of the shaft includes a retaining member that is inserted into the club head body; and (c) a locking nut engaged with a side surface of the club head body such that a body portion of the locking nut extends at least partially through the hosel and is supported by the locking nut stabilizer. The locking nut is movably engaged with the club head body such that it securely holds the shaft or allows the shaft to be removed therefrom.
US08500569B2	Golf swing training device A training device properly develops a sports equipment swing, particularly for golf equipment, to counter an overpowered back-swing that results in an uncontrolled out-of-plane downswing. The device may comprise a strap having one end secured to a latch plate, and the other end securable to a latch that releasably receives a portion of the latch plate. At least one bungee cord may have one end attached to the strap at a position relative to the latch, being approximately 4-12 inches displaced therefrom. The other bungee cord end may have a cinching device located thereon to adjustably secure the bungee cord therein to engage a golf club shaft or shaft of a sports racquet, bat or stick. The bungee cord may comprise first and second cord portions being joined together, where the first cord portion has a low elastic modulus, and the second cord portion a high elastic modulus.
US08500565B2	Non-collinear shaft coupling A coupling for connecting two non-collinear associated shafts comprises a pair of sleeves. Each sleeve has a yoke provided at an end portion thereof. The yokes are offset by 90° to one another. Each sleeve further includes a central bore for receiving an end of one of the associated shafts between which motion is to be transmitted. A knuckle is provided between each yoke of the respective sleeves. The knuckle includes a body having a plurality of openings which are offset by 90° to one another. A plurality of pins separate from the knuckle and threadingly engaged to the yokes releasably connect each yoke to the knuckle.
US08500560B2	Application interface for tracking player identity Systems and method for providing a single sign in a gaming console that associates online activity that is out-of-game/cross game, and/or online activity that is in-game, and/or activity that is offline and in-game with that account. While online, a service tracks activity of gamers and provides usage statistics in a profile. While offline, the game console tracks the player's activity via a mechanism to collect detailed information about a specific player's in-game statistics and accomplishments. The offline activity is cached and uploaded when the console connects to the online service. Players can accumulate achievements offline that are credited towards online activities.
US08500551B2	Gaming device having a selectively accessible bonus scheme A gaming device having a bonus scheme, wherein the player may choose when to play a bonus scheme, so long as the player is qualified to do so. The method of qualifying the player to enter the bonus round connects or links the base game operation of the gaming device with the bonus scheme. The reels of the base game contain symbols which alone or in combination with other symbols yield one or more bonus awards to a player. The bonus awards are escrowed and displayed a bonus award escrow display. Once the player obtains a single bonus award, the player becomes eligible or qualified to play the bonus round and the player may choose to do so at any time. The player can accumulate bonus awards and use multiple bonus awards at one time.
US08500550B2	Player tracking method and a player tracking system A method of player tracking for gaming, the method including: receiving a player identifier at a player identifier input device associated with a gaming terminal; monitoring play of the gaming terminal in response to receipt of the player identifier, the monitoring being performed to determine whether to take any action in respect of a player record of a player tracking module corresponding to the player identifier, the monitoring being carried out such that if the player identifier was received by being read from a player tracking device by the player identifier input device and the player tracking device is removed from a position at which the player tracking device can be read, the monitoring continues after the player tracking device is removed; and stopping monitoring of play of the gaming terminal automatically in response to at least one end condition occurring.
US08500547B2	Cashless gaming system: apparatus and method An apparatus and method for cashless gaming wherein a player can access credits via a pin activated keypad located on a gaming machine with a card reader and a player card. Real-time accounting allows the player to redeem credits and secure perquisites as a function of patronage. The apparatus and method can prompt the player in regards to credits remaining on a credit meter of the gaming machine if the player card is left in the card reader when credits remain on the credit meter.
US08500545B2	Method, apparatus, and program product for presenting gaming results through inverse symbol logic A gaming machine displays a number of symbol locations with a respective graphic symbol at each symbol location. Each symbol location is shown on a display system which may comprise a set of mechanical reels or reels simulated on a video display device. The display system is capable of displaying a target symbol or any other one of a number of graphic symbols included in a group of presentation symbols. In response to a first player input, each of the number of symbol locations is caused to conduct a respective symbol change process one or more times to change the graphic symbol included at each respective symbol location. At least some of the awards available in the game are based at least in part on the absence of the target symbol at one or more of the number of symbol locations.
US08500544B2	Keno simulation of other game outcomes Some implementations of the invention provide a Keno game on a gaming machine wherein an outcome of a second game is also presented. The second game may be a Class III game such as a slot game, a video poker game, etc. Some such aspects of the invention involve providing a Keno game in which the Keno card is divided into N areas and a single number within each of the N areas is selected for the Keno game. Other aspects of the invention provide methods of populating a pay table of another game with outcomes of a Keno game.
US08500537B2	Group play of a lottery game Methods and systems for facilitating play of group lottery games are described. In an embodiment, a process includes establishing at least two groups for play of a group lottery game, wherein each group includes a plurality of players. The method also includes determining at least one winning player from each group of a first round of the multiplayer lottery game, and advancing each of the winning players to a second round.
US08500536B2	Slot machine game with selection bonus game having modifier symbols A slot machine has a player selection bonus game where a player selects concealed gamepieces from a group to reveal the value of the gamepiece. The preferred game has a burger building theme in which the game rules are related to building one or more hamburgers, and the hidden gamepieces represent burger ingredients. A particular selection allows the player to win larger prizes for future selections. Other designated selections may modify future selections still further (2× and 3× multipliers for double-decker and triple-decker bun selections). Certain gamepieces may change their function based on the context or state of the bonus game.
US08500535B2	Trajectory-based 3-D games of chance for video gaming machines Trajectory-based games of chance are described that may be implemented on a video gaming machine. In a trajectory-based game of chance, a trajectory of a game object may be generated in a 3-D gaming environment. A wager may be made on an aspect of the game object's trajectory in the gaming environment such as a termination location for the trajectory of the game object. The aspect of the game object's trajectory may occur according to a known probability. Hence, an award for the trajectory-based game of chance may be proportional to the probability of the aspect of the game object's trajectory occurring.
US08500533B2	Game with chance element and strategy component that can be copied In various embodiments, a first player may follow the same pattern of betting used by a second player.
US08500530B2	Wagering system and method of wagering A wagering system has a processor through which information regarding a plurality of competing contestants in a horse or dog race is made available to entities betting on the outcome of the race to seek a payout from a wagering pool. The information for at least one of the competing contestants is prepared based upon selected handicapping criteria to give the at least one of the competing contestants a time adjusted race identity. An input is provided for wagers to be placed on the race. The outcome of the race for wagering purposes is determined using the time adjusted race identity for the at least one of the competing contestants.
US08500529B2	Bets regarding intermediate points in a race A method of providing and managing bets is provided. One or more particular race participants in a race event are determined. For each intermediate point within a race event, one or more particular possible positions of race participants at that intermediate point are determined. A bet comprising a plurality of bet components is generated, one or more of the bet components being defined by the particular race participants and the particular possible positions of race participants determined for at least one of the intermediate points. Intermediate race results are received for each intermediate point identifying the actual positions of the particular race participants at that intermediate point. A result of at least one bet component is determined based at least in part on the particular race participants, the particular possible positions of race participants determined for at least one intermediate point, and the received intermediate race results for at least one intermediate point.
US08500528B2	Combination bearing, linkage pin and shaft coupling for a damper An HVAC damper includes a sheet metal frame surrounding a series of pivotal damper blades that are each supported by a pair of plastic bearing members. Each bearing member is a unitary piece that includes a radial bearing, a thrust bearing, a lug for connecting to a damper blade, a shaft-receiving feature for connecting to a drive shaft, and multiple crank pins for selectively connecting to a drive linkage. Choosing which crank pin gets connected to the linkage determines a damper blade's rotational direction relative to the other damper blades. Adjacent damper blades preferably rotate in opposite directions to ensure positive sealing engagement between their adjacent blade tips. The bearing members allow the drive linkage to be installed outside the frame to avoid obstructing the airflow through the damper. During assembly, the bearing members allow the damper blades to be placed within the frame prior to installing the bearing members.
US08500526B2	Variable set point all-electric pressure relief valve and control, independent from the automatic cabin pressure control system A system for maintaining a desired cabin pressure in an aircraft includes a cabin-pressure control sub-system; a pressure relief valve for operation in event of failure or malfunction of the subsystem; a pressure relief valve actuator for operating the pressure relief valve; and a pressure relief valve control (PRVC) for producing commands for operation of the pressure relief valve actuator responsively to a first set of signal indicative of aircraft altitude and to presence of cabin-to-ambient pressure differential (ΔP) that varies from a desired ΔP by a predetermined amount.
US08500524B2	Method and apparatus for suspending poultry to be slaughtered A method and apparatus for suspending living or stunned poultry to be slaughtered in conveyor brackets of an overhead conveyor. A belt conveyor delivers the poultry to a distribution surface, where the poultry are successively guided or pushed outwardly against an edge of the distribution surface to individual positions for receiving the poultry with the legs projecting from the edge of the positions. The legs are fixed in fixing means at the positions. The individual positions are then successively moved upwardly relative to the distribution surface to suspend the poultry for a subsequent downward movement of the positions by brackets of the overhead conveyor running above and spaced apart from the distribution surface. The positions are subsequently moved downwardly again to the level of the distribution surface.
US08500523B1	Cutting system and method of cutting meat parts using the same A cutting system that conveys a meat product to the throat and blade of a saw. A positioning conveyor positions the meat product into a predetermined position. An adjustable laser is then used to locate a predetermined area of the meat product so that the saw blade can be adjusted to align with the laser beam before cutting of the meat product.
US08500519B2	Fluid jet assembly A fluid jet assembly includes a non-pressurized lance barrel through which a high pressure hose (“a lance hose”) is threaded and anchored at the distal end of the lance barrel relative to an operator's position. The other end of the lance hose is coupled to a high pressure fluid source. The fluid is fed into the lance hose and transported to the output of the lance barrel, where it is discharged as a fluid jet stream. A nozzle is mounted at the output of the lance barrel to control the characteristics of the fluid jet flowing out of the lance hose. When infused with an abrasive material, the fluid jet stream exits the nozzle in a focused jet capable of cutting through most structural surfaces.
US08500518B2	Method of grinding an indexable insert and grinding wheel for carrying out the grinding method In an indexable insert having wide sides, inclined narrow sides are to be ground, that is to say the grinding allowance 38 is to be removed. To this end, the indexable insert is set in rotation about a driven axis of rotation between a clamping insert and a thrust bolt. Serving for the grinding is a grinding wheel which rotates about rotation axis and which has a circumferential surface 18a contoured in a circular shape and having a largest diameter and is composed of a leading region and a trailing region. The grinding wheel is guided relative to the indexable insert along the geometrical defining line which is formed by the generating line of the finished narrow side in the feed direction. The leading region tapering forwards effects preliminary grinding of the narrow side by longitudinal grinding, whereas the trailing region effects finish grinding by linear contact with the narrow side. The grinding wheel is held with the clamping flanges on a grinding spindle. The grinding operation is effected with controlled movement of the driven axis of rotation, a first displacement axis, a second displacement axis and a pivoting movement of the grinding wheel relative to the indexable insert according to double arrow.
US08500517B2	Preparation of synthetic quartz glass substrates A synthetic quartz glass substrate is prepared by (1) polishing a synthetic quartz glass substrate with a polishing slurry comprising colloidal particles, an ionic organic compound having an electric charge of the same type as the colloidal particles, and water, and (2) immersing the polished substrate in an acidic or basic solution for etching the substrate surface to a depth of 0.001-1 nm. The method produces a synthetic quartz glass substrate while preventing formation of defects of a size that is detectable by the high-sensitivity defect inspection tool, and providing the substrate with a satisfactory surface roughness.
US08500514B2	Apparatus and method for processing piston A piston processing apparatus includes a work attaching head capable of fixing a piston material, a work rotating device, a grinding wheel, a grinding wheel rotating device, first and second moving mechanisms for moving the grinding wheel, a rotational angle detector for detecting a rotational angle of the work attaching head, a first and second position detectors for detecting a position of a grinding surface of the grinding wheel, a controller controls the first and second moving mechanisms to grind the outer circumferential surface by the grinding wheel based on target-position information of the grinding surface corresponding to a position on the outer circumferential surface of the piston material. According to the piston processing apparatus, the outer circumferential surface of the piston material can be processed into a three-dimensional shape with high-accuracy, and a piston that can improve fuel efficiency.
US08500513B2	Adjustable breast support garment A breast support garment is configured with adjustable straps, cups, and/or other components in order to facilitate modification of the appearance of the bust. Modifying the length of certain straps causes the cups to move upwards/downwards and/or inwards/outwards with respect to the center of the breast support garment. Shoulder straps or other portions of the breast support garment may pass through guide loops and/or couple to the breast cups or garment shell to permit adjustment. The location of each breast cup may be independently adjusted.
US08500512B2	Methods of operating a motorized doll A motorized doll includes an upper body portion and a lower body portion. The upper body portion may include a torso and a pair of arms. The lower body portion may include a pelvis connected to the torso at a universal joint, a pair of legs, and a pair of feet rotatable with respect to the legs. The doll is actuated to walk by a torso motor which drives the torso to tilt and rotate about the universal joint, which causes the doll to shift from foot to foot and repeatedly rotate forwards in a realistic walking motion. The doll includes a shoulder motor for rotating the pair of arms and a pelvis motor for driving the legs between a standing position and one of a crawling position or sitting position depending on the position of the pair of arms when the doll is tipped forward.

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