Document Document Title
US08487279B2 Gas contamination sensor, lithographic apparatus, method of determining a level of contaminant gas and device manufacturing method
A gas contamination sensor includes an ion source configured to generate a beam of ions from a sample of gas to be tested, and first and second ion detectors, each positioned to receive ions from the beam of ions that are deflected by different extents. The first ion detector is configured to receive ions generated from a primary gas in the gas being tested, and the second ion detector is configured to receive ions that are generated from the contaminant gas within the sample being tested.
US08487278B2 X-ray method and apparatus used in conjunction with a charged particle cancer therapy system
The invention comprises an X-ray method and apparatus used in conjunction with charged particle radiation therapy of cancerous tumors. The system uses an X-ray beam that lies in substantially the same path as a charged particle beam path of a particle beam cancer therapy system, has an elongated lifetime, and/or that is synchronized with patient respiration. The system creates an electron beam that strikes an X-ray generation source where the X-ray generation source is located proximate to the proton beam path. By generating the X-rays near the proton beam path, an X-ray path that is essentially the proton beam path is created. Using the generated X-rays, the system collects X-ray images of a localized body tissue region about a cancerous tumor, which are usable for: fine tuning body alignment relative to the proton beam path and/or to control the proton beam path to accurately and precisely target the tumor.
US08487274B2 Stroboscopic optical image mapping system
The present invention provides a stroboscopic optical image mapping system comprising a control module, an optical module, and an image acquiring unit. The control unit forms a delayed pulse signal by modulating a first pulse signal having a plurality of pulses with a pulse period, wherein a time interval between two adjacent pulses of the delayed pulse signal has a time difference with respect to the pulse period. The optical module provides an incident light to be projected on an organic object, which has a dye therein and is stimulated by a second pulse signal for generating a sequential action potential. The fluorescence generates from the dye inside the organic object, which corresponds to the intensity of the sequential action potential. The image acquiring unit is actuated to acquire the fluorescent light according to the delayed pulse signal, thereby forming a plurality of fluorescent images.
US08487273B2 Microchip and particulate fractional collection apparatus
A microchip includes a sample liquid feed channel permitting a sample liquid containing particulates to flow through, at least one pair of sheath liquid feed channels configured to merge to the sample liquid feed channel from both sides thereof for permitting a sheath liquid to flow through surrounding the sample liquid, a merging channel connected to the sample liquid feed channel and the one pair of the sheath liquid feed channels for permitting the sample liquid and the sheath liquid to merge and flow through the merging channel, a vacuum suction unit for drawing into the particulate subject to collection, connected to the merging channel, and at least one pair of discharge channels formed on both sides of the vacuum suction unit for permitting to flow through from the merging channel.
US08487272B2 Fluorescence emissions detector
A light source is gated ON and OFF in response to a pulsed signal. Photo emissions from the light source are coupled to a material under test. Resonant fluorescent emissions from the material are coupled to a photodiode. Current from the photodiode is coupled into an amplifier system comprising a first and second amplifier stages. The first amplifier stage is gated to a low gain when the light source is turned ON and the gain is increased when the light source goes from ON to OFF. The second amplifier stage has digitally programmable offset and gain settings in response to control signals. The output of the second amplifier stage is digitized by an analog to digital converter. A controller generates the pulse control signal and the control signals.
US08487267B2 Ultraviolet irradiation system
An ultraviolet irradiation system includes: an ultraviolet irradiation apparatus including a plurality of ultraviolet lamps; a flowmeter configured to measure a flow rate of the water to be treated that passes through the ultraviolet irradiation apparatus; and an ultraviolet-dose monitoring and controlling apparatus configured to monitor an ultraviolet dose of the ultraviolet irradiation apparatus and to control outputs of the ultraviolet lamps. The plurality of ultraviolet lamps include a first ultraviolet lamp and a plurality of second ultraviolet lamps. The ultraviolet irradiation apparatus includes: a first measurement head configured to measure an ultraviolet intensity of the first ultraviolet lamp; and a plurality of second measurement heads configured to respectively measure ultraviolet intensities of the plurality of the ultraviolet lamps. A distance between the first ultraviolet lamp and the first measurement head is set to a determined value.
US08487264B2 Radiation tomography apparatus
A detector ring of radiation tomography apparatus according to this invention has a fracture portion having no scintillation counter crystal arranged therein. Moreover, the radiation tomography apparatus according to this invention includes a correlated data complementation section. The correlated data complementation section forms correlated data when assuming that a first scintillation counter crystal actually provided in the detector ring is in the fracture portion, and additionally stores it to a correlated data storing section, thereby complementing correlated data in the fracture portion. As noted above, the correlated data complementation section obtains positional information under assumption that the scintillation counter crystals are in the fracture portion and a corresponding number of coincident events. Consequently, this invention may realize acquisition of faithful detecting efficiencies in the scintillation counter crystals. Therefore, the radiation tomography apparatus may be provided that allows creation of radiological images suitable for diagnosis.
US08487257B2 Device with a sandwich structure for detecting thermal radiation, and method for the production thereof
In a device for the detection of thermal radiation and a method for production of such a device, a stack is formed with a detector support having a detector element for converting the thermal radiation into an electric signal, a circuit support with a read-out circuit for reading out the electrical signal and a cover to shield the detector element. The detector support and the cover are so arranged that a first stack cavity is formed between the detector element and the cover and a second stack cavity is formed between detector support and the circuit support. The first stack cavity and/or the second stack cavity is evacuated and hermetically sealed. In the manufacturing operation, functionalized silicon-substrates are stacked upon one another, firmly bonded together and subsequently sub-divided. Preferably, the detector elements are pyro-electric detector elements. The device finds application in motion detectors, presence reporters and thermal-image cameras.
US08487256B2 Proximity sensor
A proximity sensor for use in a portable computing device is described. In particular various embodiments of a proximity sensor which fit in an extremely small portion of a cellular phone, and accurately determine the presence of a user's head in close proximity to a surface of the cellular phone.
US08487252B2 Particle beam microscope and method for operating the particle beam microscope
A method for operating a particle beam microscope comprising detecting light rays or particles which emanate from a structure, wherein the structure comprises at least one of: at least a portion of a surface of an object and at least a portion of a surface of an object holder of the particle beam microscope; generating a surface model of the structure depending on the at least one of the detected light rays and the particles; determining a position and an orientation of the surface model of the structure relative to the object region; determining a measurement location relative to the surface model of the structure; and positioning the object depending on the generated surface model of the structure, depending on the determined position and orientation of the surface model of the structure, and depending on the determined measurement location.
US08487247B2 Atmospheric pressure ionization inlet for mass spectrometers
Methods and systems for mass spectrometry and more particularly to an interface providing charged particles to a mass spectrometer are described herein.
US08487242B2 Detector device for high mass ion detection, a method for analyzing ions of high mass and a device for selection between ion detectors
Described here is a detector for measuring heavy mass ions with high sensitivity and low saturation for time-of-flight mass spectrometry and a detector housing for selecting between multiple detectors.
US08487241B2 Methods for detecting catecholamines by mass spectrometry
Provided are methods for determining the amount of one or more of one or more of epinephrine (E), norepinephrine (NE), and dopamine (D) in a sample using mass spectrometry. The methods generally involve ionizing one or more of E, NE, and D in a sample and detecting and quantifying the amount of the ion to determine the amount of one or more of E, NE, and D in the sample.
US08487239B2 Mass spectrometer
An ion source, a mass spectrometer and a method of enhancing the performance of an ion source for use with a mass spectrometer. The ion source has a housing incorporating an ion source enclosure defining a chamber and an outer cover remote from the chamber. A fluid flow passageway is provided between the ion source enclosure and the outer cover. The method of the invention comprising supplying to the ion source housing a regulated flow of fluid through the fluid passageways so as to maintain the ion source enclosure within a predetermined temperature range of substantially between 60° c. and 80° c. and preferably at 70° c.
US08487238B2 Method of identification of petroleum compounds using frequency mixing on surfaces
A method for estimating a chemical composition of a material in a borehole penetrating the earth, the method includes: placing an analysis unit into the borehole; placing a sample of the material onto an enhanced surface of the analysis unit, the enhanced surface having a feature configured to increase an electric susceptibility of the sample at an interface between the sample and the enhanced surface; illuminating the sample at the interface with a first light beam and a second light beam; measuring sum frequency light generated from the illuminating; and analyzing the sum frequency light to estimate the chemical composition of the material.
US08487236B2 Multi-optical axis photoelectric sensor
The invention provides a multi-optical axis photoelectric sensor capable of improving workability of wiring. The sensor outputs to an external apparatus a safe signal generated based upon an interrupted state of at least one optical axis among optical axes formed between the phototransmitter and the photoreceiver. The photoreceiver includes a first cable connecting section (end section case), connected with a cable including a power line for receiving power supply from the external apparatus and an output line for outputting a safe signal to the external apparatus, and a second cable connecting section (end section case), connected with a cable including a power line for performing power supply to the phototransmitter and a communication line for transmitting or receiving a timing signal that defines timing for light projection of the light projecting elements.
US08487235B2 Photoelectric sensor for sensing a target at a predetermined location
A photoelectric sensor and method for sensing a target at a predetermined location. The photoelectric sensor includes a light source that emits light, an output circuit including first and second photodetectors, and first and second receive lenses respectively positioned adjacent to the first and second photodetectors, respectively. If the target is at the predetermined location, then a first portion of the emitted light is received by the first photodetector after being reflected off of the target and passing through the first receive lens, and a second portion of the emitted light is received by the second photodetector after being reflected off of the target and passing through the second received lens. Further, the output circuit produces an output signal indicative of a sensed characteristic of the target based on signals generated by the first and the second photodetectors.
US08487231B2 Sensor pixels, arrays and array systems and methods therefor
One sensor pixel includes amplifying transistor, coupled between first bias line and data line; switch transistor, operated by control line and coupled between data line and gate of amplifying transistor; storage capacitor, coupled to second bias line; and sensor being coupled to gate of amplifying transistor. Another sensor pixel includes first amplifying transistor coupled between first bias line and data line; second amplifying transistor being coupled between second bias line and data line; switch transistor being operated by control line and being coupled between data line and gates of first and second amplifying transistors; storage capacitor coupled to gates of first and second amplifying transistors; and sensor coupled to gates of first and second amplifying transistors. Further sensor pixel includes two photo transistors connected to first and second bias lines. Trap-assisted absorption, variable capacitor described for sensor pixels, and also biasing to reduce flicker and aging, and to compensate for aging, described for sensor pixels.
US08487225B2 Microwave field director structure having metal vanes
A reusable self-supporting field director for use in a microwave oven is characterized by a plurality of vanes, each extending radially outwardly from a central axis. The vanes are supported in a slotted central support member. Each vane has a predetermined thickness dimension. Each vane comprises a substrate formed from an electrically non-conductive material having a predetermined coefficient of thermal expansion and an electrically conductive wrapper having a predetermined coefficient of thermal expansion that is different from the coefficient of thermal expansion of the substrate. The wrapper wraps the substrate so that a portion of the first and second major surfaces are covered and the radially inner end of each vane is wrapped by an electrically conductive material. The wrapper and the substrate are arranged in a laterally symmetric fashion so that thermal expansion effects due to heating are equalized across the thickness of each vane.
US08487222B2 Heating electrode and method for heating material-to-be-heated by using the heating electrode
[PROBLEMS] To provide a heating electrode which can uniformly heat a material to be heated having an irregular shape and can stably perform heating/holding-convey of the material to be heated by the heating electrode; and a method for heating food by using the heating electrode.[MEANS FOR SOLVING PROBLEMS] An assembly of pin electrodes (10) formed by conductive pins are slidably arranged in a through hole (21) of a pin support table (20). A pressure-variable gas chamber (30) whose pressure is variable is connected to the pin support table (20). By applying a plus pressure or a minus pressure to the gas chamber (30), the pin electrodes (10) are displaced relatively to the pin support table (20).
US08487221B2 Heat and/or light producing unit powered by a lithium secondary cell battery with high charge and discharge rate capability
A portable combined heating and lighting unit comprising a first element and a second element for generating thermal or light energy, and a component to convert thermal or light energy into electricity. The first element generates thermal or light energy from combustion of fuel. The second element generates thermal or light energy from electricity.
US08487215B2 Method and apparatus for welding
A method and apparatus for welding include initiating a pulse welding process includes initiating a welding arc by providing CC type welding power, maintaining the arc by providing CV type power. Then, pulse type welding power is provided. The method and system can be used to start short circuit, or other welding processes by providing short circuit power, or welding power of a given mode, instead of providing pulse power. Also, in one alternative, a method and system of initiating a pulse, short circuit, or given welding process includes initiating a welding arc by providing CC type welding power at least until a pseudo-equilibrium for the arc is established. Then, providing welding power in a pulse, short circuit, or the given mode.
US08487214B2 Mobile self-aligning universal welding carriage
A welding carriage has a frame that is adjustable in width and height and is guided by the sides of a workpiece. First and second wheel assemblies support the frame upon the workpiece, the first and second wheel assemblies forcibly engaging the sides of the workpiece for guiding the frame along a path substantially parallel thereto. The frame comprises two opposing lateral sides interconnected by a linkage therebetween. The linkage can be actuated to adjust a coarse width of the frame, dimensional variations being handles by biased guide wheels of the second wheel assembly. Each of the opposing lateral sides further has vertically adjustable leg posts for adjusting a vertical height of the frame.
US08487211B2 Method and apparatus for using multiple laser beams to weld members that are separated by a gap
A fusion welding method includes the steps of: generating a hybrid laser beam obtained by mixing a low-intensity laser beam with a first high-intensity laser beam and a second high-intensity laser beam; moving the hybrid laser beam along a gap between a first member and a second member; and melting the first member and the second member in the periphery of the gap with the hybrid laser beam, and filling the gap with the melt of the first member and the melt of the second member to weld the first member and the second member, wherein the first high-intensity laser beam is applied to the area of the first member to which the low-intensity laser beam is applied, and the second high-intensity laser beam is applied to the area of the second member to which the low-intensity laser beam is applied.
US08487209B2 Apparatus and method for laser welding
A laser welding apparatus and method reduce the effect of the fume resulting from a weld. An air injecting nozzle is installed at a laser processing head. The injecting direction of air from the air injecting nozzle is set such that the air flows across a laser beam irradiated from the laser processing head while the air flow avoids direct contact with the laser irradiating point on the work piece.
US08487208B2 Laser beam irradiation apparatus and laser working machine
A laser beam irradiation apparatus includes a laser beam oscillation unit including a pulse laser beam oscillator for oscillating a pulse laser beam and a cycle frequency setting unit for setting the cycle frequency, an acousto-optic deflection unit for deflecting the optical axis of the pulse laser beam oscillated from the laser beam oscillation section, and a control unit for controlling the acousto-optic deflection unit. The control unit outputs a driving pulse signal having a predetermined time width including a pulse width of the pulse laser beam oscillated from the pulse laser beam oscillator to the acousto-optic deflection unit based on the cycle frequency setting signal from the cycle frequency setting section.
US08487206B2 Joint product between steel product and aluminum material, spot welding method for the joint product, and electrode chip for use in the joint product
Provided is a joint product of a steel product and an aluminum material, the joint product being formed by joining the steel product having a sheet thickness t1 of 0.3 to 3.0 mm with the aluminum material having a sheet thickness t2 of 0.5 to 4.0 mm by spot welding, wherein a nugget area in a joint part is from 20×t20.5 to 100×t20.5 mm2, an area of a portion where a thickness of an interface reaction layer is from 0.5 to 3 μm is 10×t20.5 mm2 or more, and a difference between the thickness of the interface reaction layer at a joint part center and the thickness of the interface reaction layer at a point distant from the joint part center by a distance of one-fourth of a joint diameter is 5 μm or less, and wherein the aluminum material is pure aluminum or an aluminum alloy material.
US08487200B2 Structure for operating pivot switches of multi-function switch assembly
A multi-function switch assembly configured to implement a push switch function is provided. A structure for operating pivot switches of the multi-function switch assembly includes a Printed Circuit Board (PCB) disposed between upper and lower casings coupled together to face each other, push switches and rotary switches mounted on the PCB, pivot switches mounted on a bottom of the PCB, a pair of sliders disposed to cross each other at a bottom of the lower casing and configured to laterally ground and operate the pivot switches in eight directions while operating in conjunction with a manipulation direction of the actuation lever, and alignment means configured to elastically support at least one of bottoms of the pair of sliders so that restoring force of a neutral state is generated.
US08487199B2 Method of switching a surgical device
Method for operating a surgical device, comprising providing a control circuit operable to carry out at least two operational conditions of the surgical device and effecting the at least two operational conditions with a two-stage switch electrically connected to the control circuit, a first stage of the switch effecting a first of the at least two operational conditions and a second stage of the switch effecting a second of the at least two operational conditions different from the first operational condition, wherein the force required to sustain the first operational condition is less than the force required to enter the first operational condition and the force required to enter the second operational condition is greater than the force required to sustain the first operational condition.
US08487197B2 Removable push electrical fitting for electrical metallic tubing or EMT having improved pullout resistance
An electrical fitting having a gripping device with a plurality of gripping tabs forming a helix or spiral. The gripping tabs have a twist creating increased pullout resistance and easier disassembly. The electrical fitting permits electrical metallic tubing or EMT to be quickly attached to and removed from the electrical fitting without disassembling the fitting or cutting the tubing. A body with a locking end having a plurality of griping tabs receives an end of the tubing pushed into the fitting. The gripping tabs securely hold the tubing preventing loosening or removal. The helix or spiral and twist formation of the griping tabs permits easy removal of the tubing by rotating the tubing counter-clockwise.
US08487195B2 Via structure for multi-gigahertz signaling
A via structure is disclosed to pass electronic signals from a first conductive pathway formed on a first outermost substrate of a multi-layer PCB to a second conductive pathway formed on a second outermost substrate of the multi-layer PCB. The via structure allows the electronic signals to pass from the first outermost substrate through one or more inner substrates to the second outermost substrate. The one or more inner substrates include one or more closed geometric structures to enclose the via structure.
US08487190B2 Flexible printed circuit board
A flexible printed circuit board includes a substrate, signal lines, a first reinforcing layer, and a second reinforcing layer. The first surface of the substrate includes a layout zone and a reinforcing zone disposed nearby the layout zone. The signal lines are disposed on the layout zone. The first reinforcing layer is disposed on the reinforcing zone. The second reinforcing layer is disposed on the second surface of the substrate.
US08487189B2 Wired circuit board assembly sheet
A wired circuit board assembly sheet has a plurality of wired circuit boards, distinguishing marks for distinguishing defectiveness of the wired circuit boards, and a supporting sheet for supporting the plurality of wired circuit boards and the distinguishing marks. Each of the distinguishing marks has an indication portion for indicating a specified one of the wired circuit boards.
US08487181B2 Cable with embedded information carrier unit
In order to improve a cable, comprising an inner cable body, in which electrical conductor strands run in the longitudinal direction of the cable, a cable sheath, enclosing the inner cable body and lying between an outer surface of the cable and the inner cable body, and at least one information carrier unit, disposed within the outer surface of the cable, to increase the range of communication between the information carrier unit and the read/write device, it is proposed to provide the information carrier unit having an antenna unit, which can be coupled with a read/write device by parasitic electromagnetic fields between the antenna unit and at least two of the electrical conductor strands of the inner cable body.
US08487180B1 Pre-fabricated roof-mount sun-track PV carousel
A one-axis azimuth sun-tracking carousel where the PV panels are mounted at a fixed tilt in operation can be mounted on a flat roof building without roof penetration and without risk of wind damage. The carousel is prefabricated and sized to carry the maximum power while still fitting in a standard shipping container. Panel support arms fold down for shipping or in the event of a hurricane to make the carousel less than 9 inches high. Because this carousel is prefabricated and compact, it can be easily hoisted up on a roof for rapid low-cost installation. Wind skirts provide low wind resistance in high wind situations during normal operation. In order to survive high winds without roof penetration, wire tether tie points allow several carousels in an array to be tethered together and to the building parapet walls.
US08487179B2 System and method for the improvement of photovoltaic cell efficiency
A system and method for increasing photovoltaic cell efficiency is provided, comprising a photovoltaic cell, a filter covering the photovoltaic cell at a first angle to the photovoltaic cell, and a mirror positioned adjacent to the filter at a second angle to the photovoltaic cell, the mirror operable to reflect light into the filter.
US08487169B2 Adjustable item holder
A holder, comprising a retaining device adapted to selectively couple with an item and a base adapted to selectively couple with a surface, and a clamp assembly coupled with the retaining device and base. The clamp assembly allows relative adjustment of the retaining device and base members.
US08487165B1 Inbred maize variety PH18WD
A novel maize variety designated PH18WD and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH18WD with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH18WD through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH18WD or a locus conversion of PH18WD with another maize variety.
US08487163B1 Maize variety inbred PH134R
A novel maize variety designated PH134R and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH134R with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH134R through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH134R or a locus conversion of PH134R with another maize variety.
US08487162B2 Garden bean cultivar H29126
A novel garden bean cultivar, designated H29126, is disclosed. The invention relates to the seeds of garden bean cultivar H29126, to the plants of garden bean line H29126 and to methods for producing a bean plant by crossing the cultivar H29126 with itself or another bean line. The invention further relates to methods for producing a bean plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other garden bean lines derived from the cultivar H29126.
US08487160B2 Plants having improved growth characteristics and methods for making the same
The present invention relates generally to the field of molecular biology and concerns a method for increasing plant yield relative to suitable control plants. More specifically, the present invention concerns a method for increasing plant yield comprising increasing expression in a plant of a nucleic acid encoding a Dof (DNA-binding with one finger) domain transcription factor polypeptide. The present invention also concerns plants having increased expression of a nucleic acid encoding a Dof domain transcription factor polypeptide, which plants have increased yield relative to suitable control plants. The invention also provides constructs useful in the methods of the invention.
US08487159B2 Production of polyhydroxybutyrate in switchgrass
Transgenic plants, plant material, and plant cells for synthesis of polyhydroxyalkanoates, preferably poly(3-hydroxybutyrate) (also referred to a as PHB) are provided. Preferred plants that can be genetically engineered to produce PHB include plants that do not normally produce storage products such as oils and carbohydrates, and plants that have a C4 NAD-malic enzyme photosynthetic pathway. Such plants also advantageously produce lignocellulosic biomass that can be converted into biofuels. An exemplary plant that can be genetically engineered to produce PHB and produce lignocellulosic biomass is switchgrass, Panicum virgatum L. A preferred cultivar of switchgrass is Alamo. Other suitable cultivars of switchgrass include but are not limited to Blackwell, Kanlow, Nebraska 28, Pathfinder, Cave-in-Rock, Shelter and Trailblazer.
US08487151B2 Process and apparatus for filtration and pre-distribution of gas and liquid phases in a down-flow catalytic reactor
The device described in the present invention allows pre-distribution of the gas and liquid feed supplying a reactor functioning in gas and liquid co-current downflow mode to be carried out by means of a pre-distribution plate comprising a filtration medium and an overflow tube in order to regulate the flow of liquid arriving on the distributor plate located downstream of said device.More particularly, the present invention is applicable to the selective hydrogenation treatment of feeds containing acetylenic and dienic compounds.
US08487148B2 Hydrothermal treatment of biomass with heterogeneous catalyst
Biomass based feeds are processed under hydrothermal treatment conditions, e.g., to produce a hydrocarbon liquid product and a solids portion. The hydrothermal treatment can be performed in the presence of heterogeneous catalyst particles that can optionally include a catalyst metal or metal salt. The presence of the heterogeneous catalyst can modify the nature of the hydrocarbon products produced from the hydrothermal treatment.
US08487147B2 Nano-catalyst for fast track bio-diesel production from non-edible oils
Doped nanomaterials are used for the conversion of non-edible oils into biodiesels.
US08487146B2 Methods of making chlorinated hydrocarbons
Methods for the manufacture of 1,1,1,2,3-pentachloropropane from 1,1,1,3-tetrachloropropane and chlorine are disclosed. Improved methods are provided for the manufacture of 1,1,2,3-tetrachloropropene from 1,1,1,2,3-pentachloropropane. Methods are also disclosed for the manufacture of 1,1,2,3-tetrachloropropene from 1,1,1,3-tetrachloropropane and chlorine and for the manufacture of 1,1,2,3-tetrachloropropene from carbon tetrachloride, ethylene, and chlorine.
US08487140B2 Process for producing phenol
In a process for producing phenol, cyclohexylbenzene is oxidized to produce cyclohexylbenzene hydroperoxide and then the resultant cyclohexylbenzene hydroperoxide is cleaved to produce an effluent stream comprising phenol and cyclohexanone. At least a portion of the effluent stream is then fed to at least one dehydrogenation reaction zone, where the effluent stream portion is contacted with a dehydrogenation catalyst under conditions effective to convert at least part of the cyclohexanone in the effluent portion into phenol and hydrogen.
US08487138B2 Oxidation of hydrocarbons
In a process for oxidizing a hydrocarbon to a corresponding hydroperoxide, alcohol, ketone, carboxylic acid or dicarboxylic acid, the hydrocarbon is contacted with an oxygen-containing gas in the presence of a catalyst comprising a cyclic imide of the general formula (I): wherein each of R1 and R2 is independently selected from hydrocarbyl and substituted hydrocarbyl radicals having 1 to 20 carbon atoms, or from the groups SO3H, NH2, OH and NO2, or from the atoms H, F, Cl, Br and I provided that R1 and R2 can be linked to one another via a covalent bond; each of Q1 and Q2 is independently selected from C, CH, N and CR3; each of X and Z is independently selected from C, S, CH2, N, P and an element of Group 4 of the Periodic Table; Y is O or OH; k is 0, 1, or 2; 1 is 0, 1, or 2; m is 1 to 3, and R3 can be any of the entities listed for R1. The contacting produces an effluent comprising an oxidized hydrocarbon product and unreacted imide catalyst of formula (I) and the effluent is treated with an aqueous solution of a base to produce an aqueous phase comprising at least part of the unreacted imide catalyst of formula (I) and an organic phase comprising oxidized hydrocarbon product. The organic phase can then be recovered.
US08487137B2 Photochemical crosslinkers for polymer coatings and substrate tie-layer
The invention describes novel crosslinking compounds that include photoactivatable moieties. Several families of compounds are disclosed that can include one or more hydrophilic moieties that help to solubilize the compounds in aqueous environments.
US08487133B2 Substituted bicyclo [4.1.0] heptane-7-carboxylic acid amides and derivatives thereof as food flavor substances
The present invention relates to the use of a compound of the Formula (I) wherein: R1, R2, R3, R4, R5, R6, R7 and R8 denote in each case independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, or an alkenyl radical with 2 to 6 C atoms, with the proviso that at least one of the radicals R1, R2, R7 and R8 and at least one further of the radicals R1, R2, R3, R4, R5, R6, R7 and R8 are not hydrogen, wherein independently of one another also two of the radicals R1, R2, R3, R4, R5, R6, R7 and R8 can together denote a bridge with one or more bridge C atoms; Y1 and Y2 denote independently of one another hydrogen, methyl or ethyl; and Ra and Rb denote independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, an alkenyl radical with 2 to 6 C atoms or a cycloalkyl radical with 3 to 6 C atoms as a food flavor substance.
US08487132B2 Compounds for inhibition of 5-hydroxytryptamine and norepinephrine reuptake or for treatment of depression disorders, their preparation processes and uses thereof
The present invention discloses compounds of formula (I), their optical isomers or pharmaceutically acceptable salts thereof, their preparation and uses thereof, wherein the definitions of R1, R2, R3 and R4 are shown in the description. These compounds are optical isomers or racemic mixtures. After these compounds are uptaken, they are metabolically transformated in vivo into 1-[2-dimethylamino-1-(4-hydroxyphenyl)-ethyl]-cyclohexanol that has neuropharmacological activity, by interrupting reuptake of 5-hydroxytryptamine (5-HT) and/or norepinephrine (NA), which is used for treating diseases associated with central nerve system, such as depression, etc.
US08487126B2 Process for preparation of diethylenetriaminepentaacetic acid derivative, and diethylenetriaminepentaacetic acid derivative
The objective of the present invention is to provide a process for simple and efficient preparation of an intermediate compound to synthesize a gadolinium complex having a substituent for improving a retention property in blood time and specificity to an intended organ. The objective of the present invention is also to provide an intermediate compound produced by the said production process. The process for preparation of the diethylenetriaminepentaacetic acid derivative (I): wherein R1 to R5 are independently C1-6 alkyl groups; comprising the steps of: reacting a diethylenetriaminepentaacetic acid pentaester with a halogenated ally compound in an aprotic solvent; removing the excess halogenated ally compound (III); and reacting a reaction product of the diethylenetriaminepentaacetic acid pentaester and the halogenated ally compound with a base in a solvent.
US08487125B2 Method for producing caffeic acid phenyl ester and its analogues
A method for producing caffeic acid phenyl ester and its analogues, which includes the steps of: (i) reacting, in a solvent, a salt of a compound of formula (II) with an organic halide having the formula X—R2-A2 in the presence of an iodide catalyst having the formula M-I to produce caffeic acid phenyl ester or its analogue, wherein A1, R1, Q, Y, X, R2, and M are defined herein; and (ii) isolating the caffeic acid phenyl ester or its analogue from the solvent.
US08487124B2 Cyclic aza-sila compounds
The invention relates to cyclic aza-sila compounds that are made of 4 to 10 units of the general formulas (I) and (II) bonded by means of Si—Si or Si—N single bonds, wherein Y is selected from among —NR1R2, hydrogen, and a halogen, R1 and R2 are selected from among hydrogen and a hydrocarbon group having 1 to 20 carbon atoms, and R3 is a hydrocarbon group having 1 to 20 carbon atoms, with the stipulation that at least two units of the general formula (I) are bonded to each other in the ring by means of an Si—Si single bond, that at most 35 mol % of the groups Y is a hydrogen, and that at most 15 mol % of the groups Y is a halogen, and to a method for the production thereof.
US08487117B2 Atropisomers of (hydroxyalkyl) pyrrole derivatives
The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases. The compound is an atropisomer of a compound represented by the following general formula (I): wherein R1 represents a C1-C3 alkyl group; R2 represents a 2-hydroxy-C4-C6 alkyl group; R3 represents a halogeno group, a halogeno-C1-C3 alkyl group and the like; R4 represents a hydrogen atom, a halogeno group and the like; R5 represents a C1-C3 alkyl group; and R6 represents a hydrogen atom, a halogeno group and the like] or atropisomers thereof.
US08487111B2 Substituted oxazolidinones and their use
The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
US08487105B2 Process for preparing pitavastatin, intermediates and pharmaceuctically acceptable salts thereof
Processes for preparing pravastatin, intermediates and pharmaceutically acceptable salts thereof are provided Crystalline forms of pravastatin, intermediates and pharmaceutically acceptable salts thereof are also disclosed.
US08487104B2 KAT II inhibitors
The present invention relates to compounds 3-amino-1-hydroxy-2-oxo-1,2,3, 4-tetrahydroquinoline-7-carbonitrile, 3-amino-1-hydroxy-7-(2-methoxyethoxy)-3,4-dihydroquinolin-2(1H)-one, and 3-amino-1-hydroxy-7-[(1S)-2-methoxy-1-methylethoxy]-3,4-dihydroquinolin-2(1H)-one, including racemic mixtures and resolved enantiomers thereof, to pharmaceutically acceptable salts thereof, and to the treatment of cognitive deficits associated with schizophrenia and other psychiatric, neurodegenerative and/or neurological disorders in mammals, including humans.
US08487103B2 Quinoline inhibitors of hepatitis C virus polymerase
Method for treating an HCV infection and inhibiting HCV replication with a compound of formula I wherein R1, R2, R3, R4, X1, X2, X3 and X4 and as defined herein
US08487102B2 Pyrrazolopyridine compounds as dual NK1/NK3 receptor antagonists
The present invention relates to a compound of formula I wherein R1, R2, R3, Ar, and n are as defined herein or to a pharmaceutically active acid addition salt. Compounds of formula I show a high affinity simultaneously to both the NK1 and the NK3 receptors (dual NK1/NK3 receptor antagonists), useful in the treatment of schizophrenia.
US08487096B2 Imidazo[1,2-B][1,2,4]triazines as C-MET inhibitors
The present invention relates to imidazo[1,2-b][1,2,4]triazines that are inhibitors of c-Met and are useful in the treatment of c-Met associated diseases including cancer.
US08487089B2 Associative water-soluble cellulose ethers
The present invention relates to a water-soluble associative cellulose ether having a DP viscosity from 250 to 20,000 mPa·s, measured at a concentration of 1% by weight, and a molecular substitution, MS, from 0.0001 to 0.005 of a hydrophobic substituent containing an unsubstituted or substituted hydrocarbon group of 8-24 carbon atoms. The cellulose ether has a good thickening effect and advantageous application properties at low contents and can be used in an aqueous decorative paint composition, an aqueous paper coating composition, an aqueous organic filler composition, an aqueous cement slurry, an aqueous detergent composition or an aqueous personal care formulation.
US08487084B2 DNA-guided nanoparticle assemblies
In some embodiments, DNA-capped nanoparticles are used to define a degree of crystalline order in assemblies thereof. In some embodiments, thermodynamically reversible and stable body-centered cubic (bcc) structures, with particles occupying <˜10% of the unit cell, are formed. Designs and pathways amenable to the crystallization of particle assemblies are identified. In some embodiments, a plasmonic crystal is provided. In some aspects, a method for controlling the properties of particle assemblages is provided. In some embodiments a catalyst is formed from nanoparticles linked by nucleic acid sequences and forming an open crystal structure with catalytically active agents attached to the crystal on its surface or in interstices.
US08487083B2 Monoclonal antibodies capable of simultaneously binding domains II and IIIc of type 1 fibroblast growth factor receptor
The invention pertains to the field of medicine, particularly to methods for suppressing the growth of tumors, which comprise blocking the pathological pathway of human fibroblast growth factor/receptor 1 (domains II and IIIc), and for diagnosing malignant neoplasms leading to an excessive proliferation of tumor cells and to the formation of new vessels accompanied by the growth of primary tumors and metastases. This pathway also represents an independent mechanism of tumor resistance to preparations acting on other pathological pathways. Blocking the aforementioned pathway using various substances that neutralize the receptor by bonding only with domains II and IIIc thereof results in the interruption or slow-down of tumor growth. This receptor can also be used as a target for delivery of diagnostic agents being largely present in tumor cells. The invention enables developing new agents for diagnosing and treating diseases related to excessive proliferation and neovascularization.
US08487081B2 Antibodies specific for human hepcidin
The present invention relates to antigen-binding proteins having specificity for hepcidin, and their use for treating and diagnosing diseases associated with hepcidin.
US08487079B2 Use of mitochondria-targeted electron scavengers as anti-inflammatory agents
Provided herein are methods for using mitochondria-targeted electron scavengers as anti-inflammatory agents. The mitochondria-targeted electron scavenger comprises a free radical-scavenging group covalently linked to a mitochondria-targeting group derived from a hemigramicidin moiety. The mitochondria-targeted electron scavenger can be used to treat medical conditions associated with acute or chronic inflammation.
US08487077B2 Simplified one-pot synthesis of [18F]SFB for radiolabeling
A non-aqueous single pot synthesis of [18F]SFB is set forth. The [18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody) targeting human epidermal growth factor receptor 2 (HER2) as representative examples of labeled compounds for use as an injectable composition to locate abnormal tissue, specifically tumors within an animal or human using a PET scan.
US08487074B2 Modulation of lipid rafts
The present invention relates to the use of an antisecretory protein, derivative, homologue, and/or fragment thereof, having equivalent activity, and/or a pharmaceutically active salt thereof, for the manufacture of a pharmaceutical composition and/or a medical food for the treatment and/or prevention of dysfunction, e.g. abnormal function, hypo- or hyper-function of lipid rafts, receptors and/or caveolae. A dysfunction of lipid rafts, receptors and/or caveolae may be caused by or be a cause of a variety of other conditions, which are also encompassed by the present invention, such as vascular, and lung dysfunctions, and/or endocrine disorders, e.g. diabetes and related disorders. Furthermore, the invention relates to a method for the treatment and/or prevention of dysfunction of lipid rafts and/or caveolae in a mammal in need thereof.
US08487071B2 Polyether polymer and production process thereof
A polyether polymer containing a defined polymerization unit (—R1—O—R2—O—), R1 and R2 being derived from monomers (A) and (B), respectively; and a process for producing the polyether polymer comprising the step of copolymerizing the monomer (A) with the monomer (B) in the presence of a metal salt, wherein the monomer (A) is (A1) a non-conjugated mono-cyclic diene compound containing a cyclic skeleton, or (A2) a non-conjugated cyclic diene compound containing a mutual linking of plurality of a mono-cyclic structure having a cyclic skeleton, and the monomer (B) is an aliphatic diol, an alicyclic diol or a divalent phenol.
US08487065B2 Copolycarbonate-polyesters, methods of manufacture, and uses thereof
A copolycarbonate-polyester, comprising units of formula wherein at least 60 percent of the total number of R1 groups are divalent aromatic organic radicals and the balance thereof are divalent aliphatic or alicyclic radicals; units of formula wherein T is a C7-20 divalent alkyl aromatic radical or a C6-20 divalent aromatic radical, and D is a divalent C6-20 aromatic radical; and units of the formula wherein R2 and R3 are each independently a halogen or a C1-6 alkyl group, R4 is a methyl or phenyl group, each c is independently 0 to 4, and T is as described above. A method of making a copolycarbonate-polyester is also disclosed.
US08487064B2 Polymer compounds and a preparation method thereof
Disclosed herein are polymer compounds and a method for preparing thereof. More specifically, provided are polymer compounds with well-connected, narrow size distribution free-volume element and a method for preparing the polymer compounds by thermal rearrangement for aromatic polyimides containing ortho-positioned functional groups in the solid state.
US08487062B2 Polyimidesilicone having alcoholic hydroxyl group and process for producing the same
The present invention provides a polyimidesilicone having a primary alcoholic hydroxyl group, which is represented by the following general formula (1): in which k and m are each a positive integer where k and m satisfy a relation of 0.01≦k/(k+m)<1; and X, Y and W are as those defined in the specification.
US08487061B2 Star hydrocarbon polymer, process for making, and a polymer blend composition having same
Provided is a process for making a saturated star hydrocarbon polymer. The process has the following steps: (A) hydrosilylating tetraethylene silicon with methyldichlorosilane in the presence of a hydrosilylating catalyst to form a chlorosilane dendrimer; (B) reacting the chlorosilane dendrimer with vinylmagnesium bromide in the presence of a lithium and/or organolithium initiator stepwise to build a higher generation chlorosilane dendrimer; (C) anionically polymerizing polybutadiene in the presence of a lithium and/or organolithium initiator to form living poly(butadienyl)lithium; (D) attaching the living poly(butadienyl)lithium to the higher generation dendrimer to form a star polybutadiene; and (E) hydrogenating the star polybutadiene to form the saturated star hydrocarbon polymer. There is also provided a saturated star hydrocarbon polymer made according to the above process and a polymer composition of a matrix ethylene polymer and the saturated star hydrocarbon polymer.
US08487058B2 Wettable silicone hydrogel contact lenses
Ophthalmically acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer. The lenses have ophthalmically acceptably wettable lens surfaces when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.
US08487056B2 Positive resist composition and method of forming resist pattern
A positive resist composition including a base component (A) which exhibits increased solubility in an alkali developing solution under action of acid and an acid-generator component (B) which generates acid upon exposure, the base component (A) including a polymeric compound (A1) containing a structural unit (a0) represented by general formula (a0-1), a structural unit (a1) derived from an acrylate ester containing an acid dissociable, dissolution inhibiting group, and a structural unit (a3) derived from an acrylate ester containing a hydroxy group-containing aliphatic hydrocarbon group represented by general formula (a3-1), and the amount of the structural unit (a3) based on the combined total of all structural units constituting the polymeric compound (A1) being in the range of 1 to 30 mol %.
US08487055B2 Hole transport polymers
There is provided a polymer made from a monomer having Formula I: where: R and Y are independently selected from the group consisting of H, D, alkyl, fluoroalkyl, aryl, fluoroaryl, alkoxy, aryloxy, NR″2, R′, R′ is a crosslinkable group; R″ is independently selected from the group consisting of H, alkyl, fluoroalkyl, aryl, fluoroaryl, and R′; X is a leaving group; Z is C, Si, or N; Q is (ZR″n)b; a is an integer from 0 to 5; b is an integer from 0 to 20; c is an integer from 0 to 4; q is an integer from 0 to 7; and n is an integer from 1 to 2.
US08487054B2 Benzopinacol metalloester polymerization initiator
A polymerization initiator based on boroesters of benzopinacol for curing unsaturated polymers is disclosed. Methods of preparing the benzopinacol boroester initiator and using the initiator in polymerization reactions are additionally disclosed.
US08487051B2 Polyurethane based pigment dispersants which contain reactive double bonds
Polymeric urethane dispersants with solubilizing polymer chains and with reactive carbon to carbon double bonds are described. The reactive double bonds facilitate molecular weight build-up of the dispersant on dispersed particles (enhancing colloidal stability) or enhance the ability of the dispersants to be crosslinked into a matrix material.
US08487050B2 Composition containing fluorine-containing aromatic polymer and laminated body containing fluorine-containing aromatic polymer
A composition comprises a fluorine-containing aromatic polymer, an epoxy compound and an initiator. Its use as film, laminate with polyimide or copper foils, copper-clad laminated board and adhesive film. The fluorine-containing aromatic polymer is preferably a fluorine-containing aryl ether polymer. The initiator is preferably a cationic initiator.
US08487048B2 Water-absorbent resin and its production process
Objects of the present invention are: to provide a water-absorbent resin which exhibits excellent balances between water absorption performances; and further to provide a process by which a water-absorbent resin having excellent absorption properties can be produced even if no hydrophilic organic solvent is used, or even if its amount is extremely reduced, when carrying out the surface-crosslinking treatment; and further to provide a water-absorbent resin optimum to absorbent articles such as diapers. As a means of achieving these objects, the process according to the present invention for production of the water-absorbent resin comprises: a step (1) of polymerizing a monomer component including an acid-group-containing unsaturated monomer as an essential component to thereby obtain a hydrogel polymer; a step (2) of drying and pulverizing the hydrogel polymer to thereby obtain a water-absorbent resin powder; a step (3) of adding a surface-crosslink-treating agent to the water-absorbent resin powder, wherein the surface-crosslink-treating agent includes a surface-crosslinking agent and water as essential components and has a hydrophilic organic solvent content of 0 to 10 mass % relative to the surface-crosslink-treating agent; and a step (4) of heating the resultant mixture to thereby carry out surface-crosslinking treatment; wherein a time of from the end of the step (3) till the beginning of the step (4) is within 5 minutes.
US08487047B2 68Ga generator
The present invention relates to a 68Ga generator, wherein the 68Ge parent nuclide thereof is attached specifically to a support through a triethoxyphenyl group and continuously disintegrates to 68Ga, the triethoxyphenyl group being covalently bound to a support material through a linker.
US08487044B2 Oriented white polyester film
The invention provides a oriented white polyester film, which includes at least one polyester film with a cavitation additive, wherein the cavitation additive includes poly(methyl methacrylate-co-methyl methacrylamide), a copolymer of sulfophthalate salt and nylon, polyarylate (PAR), ethylene methacrylate (EMA), ethylene methacrylate acrylic acid terpolymer (EMAAA), polyetherimide (PEI), metallocene catalyzed cyclic olefin copolymer (mCOC) or combinations thereof.
US08487043B2 Phosphorous flame retardant and application thereof to polymer
A phosphorous flame retardant primarily includes hexachlorotriphosphazene (HCP) having poly(oxyalkylene)amine substitutes. The poly(oxyalkylene)amine includes at least two end groups. The phosphorous flame retardant can further include layered silicate clay. The layered silicate clay can be intercalated and modified with the poly(oxyalkylene)amine substitutes of HCP to effectively promote thermal stability. The flame retardant, phosphazene-poly(oxyalkylene)amine adducts, can be applied to a polymer. By the cross-linking between them, the flame-retarding property of the polymer can be improved. Also provided is a method for producing the flame retardant of phosphazene-poly(oxyalkylene)amine adducts and application thereof to a polymer.
US08487041B2 Unsaturated polyester
The present invention relates to a resin composition comprising (a) an unsaturated polyester resin having a molecular weight Mn of at least 750 Dalton and at most 5000 Dalton and (b) a reactive diluent, wherein the unsaturated polyester resin comprises C5-C10 unsaturated diacid building blocks and isosorbide building blocks. Preferably, at least part of the isosorbide is derived from a non-fossil source. Preferably, itaconic acid or anhydride is used as the C5 unsaturated dicarboxylic acid.
US08487025B2 Branched melt polycarbonate with low content of defective structures
The present invention relates to an aromatic branched polycarbonate, produced via melt transesterification of a bisphenol with a diaryl carbonate in the presence of a branching agent, wherein the aromatic branched polycarbonate comprises branching point structures and structures of formula (D) wherein X is a single bond, C1- to C6-alkylene, C2- to C5-alkylidene or C5- to C6-cycloalkylidene, optionally substituted by C1- to C6-alkyl; wherein the amount of D in the aromatic branched polycarbonate is in the range of from 5 to 450 mg per kg of the aromatic branched polycarbonate; and wherein the ratio of the total branching point structures to the total structures of the formula D in the aromatic branched polycarbonate is in the range of from 8 to 200.
US08487021B2 Bone treatment systems and methods
The present disclosure relates to bone cement formulations that have an extended working time for use in vertebroplasty procedures and other osteoplasty procedures together with cement injectors that include energy delivery systems for on-demand control of cement viscosity and flow parameters. The bone cement formulations may include a liquid component having at least one monomer and a non-liquid component including polymer particles and benzoyl peroxide (BPO). The non-liquid component may be further configured to allow controlled exposure of the BPO to the liquid monomer so as to enable control of the viscosity of the bone cement composition.
US08487019B2 Filled resins and method for making filled resins
A method of making a filled resin includes providing functionalized particles; and combining and homogenously mixing the functionalized particles with an organic matrix in a vacuum kneader to provide the filled resin so that the functionalized particles comprise at least about 20% by weight of the filled resin. The step of providing functionalized particles can also include providing a feedstock of (i) untreated particles, (ii) a surface treatment agent reactive with the particles, and (iii) solvent, and directing the feedstock through a continuous reactor maintained at a temperature sufficient to react the particles with the surface treatment agent to provide the functionalized particles in less than about 4 hours; and directing the functionalized particles from the continuous reactor directly into the vacuum kneader. In another aspect, the a finished resin comprises at least about 20% by weight of functionalized particles in an organic matrix.
US08487018B2 Heavy metal-free and anaerobically compostable vinyl halide compositions, articles and landfill biodegradation
Heavy metal-free compostable polymers, composites and articles anaerobically biodegrade in landfills in a relatively short time. Heavy metal-free composite polymeric articles and sheets such as indoor or outdoor signs, billboards, banners, images, protective barriers, backdrops and wall coverings have very useful service durations and yet are landfill biodegradable.
US08487015B2 Flexible polyurethane foam and process for its production
A process for producing a flexible polyurethane foam, which comprises reacting a polyol mixture with a polyisocyanate compound in the presence of a urethane-forming catalyst and a blowing agent, characterized in that the polyol mixture comprises the following polyol (A) and the polyol (B), and the proportion of the polyisocyanate compound to the polyol mixture is at least 90 by isocyanate index, and the total amount of Zn and Co contained in the polyol mixture is from 0.1 to 200 ppm.
US08487014B1 Silica filler pretreated with bio-based polyol and elastomer composition containing the same
In one embodiment, a filler composition includes a filler including silica; and a bio-based oil contacting the filler and including at least one soy polyol, wherein an elastomer, if present, is less than 25 weight percent of the total weight of the filler composition. The filler composition does not contain appreciable amount of petroleum oil, which if present, is less than 25 weight percent of the filler composition. The filler composition does not contain appreciable amount of epoxidized oil which, if present, is less than 25 weight percent of the total weight of the filler composition. The soy polyol may include a hydroxyl number of from 10 to 350 KOH/g. The bio-based oil may further include soy oil.
US08487010B1 Converting carbon oxides in gas phase fluids
A process for reducing the carbon oxide content in natural gas, by producing a carbon oxide containing natural gas from a geological formation through a natural gas delivery system; providing a reaction zone containing at least one catalyst suitable for hydrocarbon conversion in the natural gas delivery system; introducing hydrogen into the carbon oxide containing natural gas to form a reaction mixture; and passing the reaction mixture to the catalyst in the reaction zone to convert at least a portion of the carbon oxides in the natural gas to hydrocarbons.
US08487002B2 Controlled-release compositions
A solid dosage formulation having a core with a pharmacological agent dispersed in a first controlled-release matrix from which release of the agent is relatively slow; and a coat formed over the core and having the agent dispersed in a second controlled-release matrix from which release of the agent is relatively fast. The first matrix can be a cross-linked high amylose starch and the second matrix can be a mixture of polyvinyl acetate and polyvinylpyrrolidone.
US08486999B2 Long-chain oxyaminopolyol based gelator and gel
[PROBLEMS TO BE SOLVED]It is an object of the present invention to provide a gelator containing a long chain oxyaminopolyol capable of forming a gel with a small amount thereof over a liquid property range from acidic to alkaline, and a gel having high environmental suitability, biocompatibility and biodegradability.[MEANS FOR SOLVING THE PROBLEMS]A gelator, characterized by containing a long chain oxyaminopolyol of Formula (I): (where R1 is a C12-16 saturated aliphatic group or a C12-16 unsaturated aliphatic group having one double bond; R2 is a substituent which an amino acid has; and X is an oxygen atom or NH) and a pharmaceutically acceptable salt thereof; a self-assembly formed by the self-assembly of the gelator; and a gel containing the gelator or the self-assembly, and water, an aqueous solution, a hydrophilic organic solvent or a hydrophilic organic solution, or a hydrophobic organic solvent or a hydrophobic organic solution.
US08486997B2 External preparation for skin
An external preparation for skin containing an alkylresorcinol and being excellent in temperature stability (especially high-temperature stability) and photostability. More particularly an external preparation for skin comprising (a) from 0.01 to 5% by mass of 4-isobutyl resorcinol or a salt thereof, and (b) from 0.01 to 5% by mass of one or more selected from L-ascorbic acid or a salt thereof and a 3-O-alkyl-L-ascorbic acid or a salt thereof. If desired, (c) one or more compounds selected from (c-1) a sterol skeleton-having compound (e.g., POE phytosterols, POE cholestanols), (c-2) a vitamin E derivative, (c-3) a compound such as polyglycerin fatty acid esters, polyoxybutene-polyglycerin alkyl ethers, sucrose fatty acid esters, and (c-4) a sorbitan skeleton-having compound may be incorporated in the preparation.
US08486995B2 Acaricidal active substance combinations
Disclosed is a method of controlling insects or acarids comprising contacting crops or their environment with a compound of the formula (I): and least one compound selected from the group consisting of: bifenazate, fenpyroximate pyridaben, fenazaquin, abamectin, emamectin benzoate, fenpropathrin and propargite.
US08486993B2 Solid dispersions comprising tacrolimus
A pharmaceutical composition comprising tacrolimus (FK-506) dissolved and/or dispersed in a hydrophilic or water-miscible vehicle to form a solid dispersion or solid solution at ambient temperature have improved bioavailability.
US08486992B2 Carboxamide derivatives as muscarinic receptor antagonists
The invention relates to compounds of formula processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.
US08486990B2 SirT inhibitors that bind to NAD
Compound of formula (I) and methods of treating disorders by administering a compound of formula (I) are described herein. Examples of disorders include neoplastic disorders, fat-cell related disorders, neurodegenerative disorders, and metabolic disorders.
US08486989B2 Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
The present invention relates to peptidomimetic compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention.
US08486987B2 Mechanism-based small-molecule parasite inhibitors
Methods for preventing or treating an Apicomplexan parasite infection in a patient administering to a patient in need thereof an effective amount of a compound of Formulas I-IV.
US08486983B2 Self-emulsifying formulations of CETP inhibitors
A liquid formulation for oral administration of the CETP inhibitor of formula (I) has improved bioavailability compared with conventional solid formulations. The formulation comprises the CETP inhibitor, or a pharmaceutically acceptable salt thereof; an oil; and one or more nonionic surfactants having a hydrophilic lipophilic balance (HLB)>10.
US08486981B2 Selective ligands for the dopamine 3 (D3) receptor and methods of using the same
Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula: wherein R1 is C1-6 alkyl or C3-6cycloalkyl; or wherein R2 is substituted with one or two halogen(s) or OC1-3alkyl.
US08486980B2 Tricyclic compound
Provided is a tricyclic compound having a PPAR γ agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:
US08486979B2 1,2,4 oxadiazole compounds and methods of use thereof
The invention relates to 1,2,4 oxadiazole compounds and analogs thereof, represented by formula (II), and compositions and methods of use thereof.
US08486978B2 Compositions and methods for treating diseases of the nail
Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, which composition has a surface tension of 40 dynes/cm or less and has continuing spreadability, and which composition is effective in treating a disorder of the nail or nail bed.
US08486977B2 1,2,3-triazole derivatives for use as stearoyl-CoA desaturase inhibitors
The present invention relates to substituted triazole compounds of the formula (I): and pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds for modulating SCD activity.
US08486976B2 Enhanced migraine treatments based on ghrelin mimetics
The present invention relates to method of enhancing the absorption of migraine medications and thereby treating migraines by co-administering to a subject in need thereof an effective amount of a ghrelin mimetic or pharmaceutically acceptable salt, hydrate or solvate thereof and at least one migraine medication selected from a serotonin 5-HT1B/1D receptor agonist, a tryptamine derivative, an ergoline derivative, a non-steroidal anti-inflammatory drug, or an analgesic, or any combination thereof.
US08486973B2 Sublingual fentanyl spray
The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable salt thereof, or derivative thereof, suitable for administration to a patient, and methods for treatment with the formulations.
US08486972B2 Sublingual fentanyl spray
The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable salt thereof, or derivative thereof, suitable for administration to a patient, and methods for treatment with the formulations.
US08486968B2 Compounds
This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, L, M, W, R1, R2, R3, R4, R6, R7, Ra, Rb have meanings given in the description.
US08486967B2 Heteroaryl substituted piperidines
The invention relates to compounds of formula where hetaryl I, hetaryl II, R1, R2, R3, R4, m, n, and o are as defined in the specification or to pharmaceutically active acid addition salts thereof. The compounds of formula I are modulators for amyloid beta and thus may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.
US08486966B2 9-(pyrazol-3-yl)-9H-purine-2-amine and 3-(pyrazol-3-yl) -3H-imidazo[4,5-B] pyridin-5-amine derivatives and their use for the treatment of cancer
The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer.
US08486965B2 Pyrrolo[2,3-b]pyridine derivative and use thereof for treatment of cancer
The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof.Specially, the present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or salt thereof, and a medicament containing the compound or a prodrug thereof, which is an Smo inhibitor or an agent for the prophylaxis or treatment of cancer.
US08486960B2 Formulations and methods for vascular permeability-related diseases or conditions
Described herein are formulations and methods for treating, inhibiting, preventing, delaying onset, or causing regression of a disease or condition relating to vascular permeability.
US08486954B2 Heterobicyclic carboxamides as inhibitors for kinases
The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.
US08486952B2 Compounds for the reduction of β-amyloid production
The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.
US08486950B2 Janus kinase inhibitor compounds and methods
The invention provides compounds of Formula I, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, B, D, R1, R2, R4 and R5 are defined herein, a pharmaceutical composition that includes a compound of Formula I and methods of use thereof.
US08486949B2 Use of azaperone for improving growth performance
The present invention relates to a method for improving growth performance in animals without causing sedation by orally administering azaperone in a low dose together with food or drinking water. Improving growth performance comprises the increase of growth rate over a certain period of time.
US08486946B2 Pyrazolo [4,3-c] cinnolin-3-one M1 receptor positive allosteric modulators
The present invention is directed to pyrazolo[4,3-c]cinnolin-3-one compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
US08486943B2 Tetrahydrocyclopenta[b]indole androgen receptor modulators
The present invention provides a compound of the Formula (I), or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating or preventing physiological disorders, particularly reduced bone mass, osteoporosis, osteopenia, reduced muscle mass or strength, or erectile dysfunction comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
US08486942B2 Modulators of pharmacokinetic properties of therapeutics
The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
US08486936B2 Antagonist of smoothened
Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary diseases and disorders.
US08486930B2 Salts
This invention relates to a hydrochloride, malate, oxalate and tartrate salt forms of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this salt, to processes for forming this salt and to its use in medical treatment. In addition, the present invention also relates to new polymorphic forms of each of these salts, as well as to pharmaceutical compositions comprising these polymorphic forms, to processes for obtaining them, and their use in medical treatment.
US08486928B2 Super-oxide dismutase mimetics
The present invention relates to compounds which are effective as catalysts for dismutating superoxide and, more particularly, the manganese or iron complexes of substituted, unsaturated heterocyclic 16-membered macrocyclic complexes that catalytically dismutate superoxide. It also relates to methods of using these complexes to reduce the concentration or the effects of superoxide, pharmaceutical compositions comprising these compounds or their metal complexes, and methods of treating conditions associated with excessive superoxide activity.
US08486927B2 Crystalline forms of lamotrigine
The invention is directed to novel crystalline forms of lamotrigine. These novel crystalline forms of lamotrigine have improved dissolution and in-vivo absorption profile, as compared to pure lamotrigine. These novel crystalline forms of lamotrigine provide a substantial increase in the blood concentration of lamotrigine, as compared to pure lamotrigine when administered to a subject. These novel crystalline forms of lamotrigine also provide a slower, steady build up of lamotrigine blood concentration suitable for sustained release of lamotrigine in-vivo, as compared to pure lamotrigine.
US08486923B2 Use of the combination of ciclesonide and antihistamines for the treatment of allergic rhinitis
The subject matter of this application relates to the combination of ciclesonide with an antihistamine.
US08486921B2 Synthesis of tetracyclines and analogues thereof
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetra-cycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-pro liferative agents in the treatment of diseases of humans or other animals.
US08486919B2 4-alkylresorcinol derivative and external preparation for skin containing the same
The present invention provides a compound that has a high whitening effect and is excellent in safety and stability and provides an external preparation for skin comprising the same. The compound of the present invention is a 4-alkylresorcinol derivative represented by formula (1) or a salt thereof: wherein R1 is a branched or cyclic alkyl group of 3 to 7 carbon atoms or a linear alkyl group of 2 to 5 carbon atoms; R2 and R3 are each independently a hydrogen atom or a group represented by —P(O)(OR4)(OR5), and at least one of R2 and R3 is a group represented by —P(O)(OR4)(OR5); and R4 and R5 are each independently a hydrogen atom or a linear or branched alkyl group of 2 to 5 carbon atoms.
US08486914B2 Hirsutella sinensis mycelia compositions and methods for treating sepsis and related inflammatory responses
Compositions comprising Hirsutella sinensis mycelia extracts and chromatographically separated polysaccharide-enriched fractions thereof are provided. Methods for extracting Hirsutella sinensis mycelia are provided. Compositions for methods for their use in amelioration, prevention and treatment of sepsis, acute endotoxemia and inflammatory responses are disclosed.
US08486907B2 Antisense oligonucleotides for inducing exon skipping and methods of use thereof
An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
US08486900B2 Method for preparing a Centella asiatica extract rich in madecassoside and in terminoloside
The invention concerns an extract of Centella asiatica comprising more than 75 wt. % of a mixture of madecassoside, terminoloside and asiaticoside, relative to the extract total weight, an extract of Centella asiatica comprising more than 95 wt. % of a mixture of madecassoside and terminoloside relative to the extract total weight and their use for regulating inflammatory mechanisms.
US08486894B2 Synthetic peptide amides and dimeric forms thereof
The invention relates to synthetic peptide amides that are ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure: wherein Xaa is a D-amino acid and G is selected from the following three groups: The compounds are useful in the prophylaxis and treatment of pain, pruritis and inflammation associated with a variety of diseases and conditions.
US08486888B2 Methods for use of branched amino acids
The invention provides an orally-administrable nutritional product comprising a dipeptide including a branched chain amino acids (BCAA). In one embodiment, the nutritional product comprises a dipeptide selected from at least one of the following: alanyl-leucine, alanyl-isoleucine, alanyl-valine, glycyl-leucine, glycyl-isoleucine, and glycyl-valine.
US08486882B2 Metal cleaner polisher and anti-tarnish solution
The present invention is directed to a metal cleaner polisher and anti-tarnish solution which comprises the following ingredients per 32 fluid ounces: 5.00 to 10.00 percent mineral spirits by volume; 1.50 to 4.50 percent ethanol by volume; 0.50 to 1.50 percent ammonia by volume; 0.50 to 1.50 percent thiourea by volume; 0.25 to 1.00 percent sulfamic acid by volume; less than 0.20 percent disodium cocoampho-diproprionate by volume; and deionized water. Optionally, the following ingredients may be added individually, in any combination or all together: thickening/suspension agents; abrasive additives; and a modifying/stabilizing agent; and optionally varying amounts of fragrance and colorizing agents.
US08486880B2 Composition for removing a photoresist and method of manufacturing semiconductor device using the composition
Provided are a composition for removing a photoresist and a method of manufacturing a semiconductor device using the composition. The composition includes about 60-90 wt % of dimethyl sulfoxide, about 10-30 wt % of a polar organic solvent, about 0.5-1.5 wt % of hydroxy alkyl ammonium and about 1-10 wt % of an amine containing no hydroxyl group.
US08486877B2 Alkylated hydroxyaromatic compound substantially free of endocrine disruptive chemicals
An alkylated hydroxyaromatic compound is disclosed which is prepared by reacting at least one hydroxyaromatic compound with at least one branched olefinic propylene oligomer having from about 20 to about 80 carbon atoms in the presence of an acid catalyst, wherein the at least one branched olefinic propylene oligomer is substantially free of any vinylidene content. The alkylated hydroxyaromatic compound has been determined to be substantially free of endocrine disruptive chemicals when the effects were quantified on pubertal development and thyroid function in the intact juvenile female rat.
US08486876B2 Functional fluids for internal combustion engines
A functional fluid suitable for use in an internal combustion engine is provided, comprising: (a) a major amount of a base fluid; (b) a minor amount of a polysubstituted alkanol amine derivative reaction product obtainable by reacting: (i) a carboxylate compound of formula I R1COOR2  (I) in which: R1 is an aliphatic C1-30-hydrocarbon radical; and R2 is hydrogen or alkyl, mono- or polyhydroxyalkyl, or ammonium; with (ii) an alkanol amine of the formula II NHR3R4  (II) wherein R3 and R4 are independently selected from hydrogen atoms and linear or branched-chain hydrocarbon groups, the carbon chain of which is optionally interrupted by one or more —NH— groups and which optionally has at least one hydroxyl group attached to a carbon atom of the hydrocarbon group, with the proviso that R3 and R4 are not both hydrogen atoms and that at least one of said residues R3 and R4 carries at least one hydroxyl group; in a molar ratio of the —COO— groups of the carboxylate compound of formula I to the molar sum of OH and NH groups of the alkanol amine of formula II in a range and under reaction conditions supporting the formation of a reaction product comprising polysubstituted alkanol amine derivatives; and (c) a minor amount of a detergent additive.
US08486875B2 High- and low-viscosity estolide base oils and lubricants
Provided herein are compounds of the formula: in which n is an integer equal to or greater than 1; R2 is selected from hydrogen and optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched; and R1, R3, and R4, independently for each occurrence, are selected from optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched, wherein compositions comprising the compounds are characterized by particular combinations of values for estolide number, kinematic viscosity, and pour point. Also provided are compositions containing the compounds and methods of making both the compounds and compositions thereof.
US08486874B2 Water-soluble processing oil agent
To provide a water-soluble working fluid which less adversely affects the human body and the ecological system as compared with conventional water-soluble working fluids, which has high rotting resistance, and which provides excellent working performance. The water-soluble working fluid of the invention contains methyldicyclohexylamine.
US08486872B2 Silicone lubricant with good wetting on PET surfaces
The passage of a container along a conveyor is lubricated by applying to the container or conveyor a composition comprising a water-miscible silicone material wherein the composition has good wetting to polyethylene terephthalate surfaces. The compatibility of the lubricating composition with polyethylene terephthalate is increased because the wetting of the composition to polyethylene terephthalate is improved.
US08486871B2 Lubricant for compression type refrigerating machine and refrigeration system using the same
A lubricating oil for a compression-type refrigerator using a hydrofluorocarbon refrigerant including a polyvinyl ether-based compound containing in the molecule an alkylene glycol unit or a polyoxyalkylene glycol unit and a polyvinyl ether unit and having a molecular weight in the range of 300 to 3,000, and a refrigeration apparatus using the lubricating oil.The present invention can provide a lubricating oil for a compression-type refrigerator having good compatibility in the atmosphere of a hydrofluorocarbon and a high viscosity index, and a refrigeration apparatus using such a lubricating oil.
US08486868B2 Settable compositions comprising unexpanded perlite and methods of cementing in subterranean formations
An embodiment of the present invention comprises a method of cementing comprising: placing a settable composition into a well bore, the settable composition comprising unexpanded perlite, cement kiln dust, and water; and allowing the settable composition to set. Another embodiment of the present invention comprises a method of cementing comprising: placing a settable composition into a well bore, the settable composition comprising ground unexpanded perlite, Portland cement interground with pumicite, and water; and allowing the settable composition to set. Yet another embodiment of the present invention comprises a settable composition comprising: ground unexpanded perlite; cement kiln dust; and water.
US08486867B2 Method of fracturing using mannanohydrolase enzyme breaker
A thermophilic mannanohydrolase enzyme may be used as an enzyme breaker for fracturing fluids containing hydratable polymers of guar and underivatized guar. The amino acid sequence of the mannanohydrolase is at least 90% homologous to the amino acid sequence of SEQ ID NO:2.
US08486866B2 Method for the quantitative measurement of biomolecular targets deposited on a biochip, and device for implementing it
The present invention relates in particular to a method for the quantitative measurement of biomolecular targets that have been deposited on a biochip (1) of the type with a matrix of probes hybridized by the targets, the matrix comprising a multitude of measurement points (2) each comprising a plurality of probes, characterized in that it comprises the following steps: a) at least one laser beam (18) is focused onto each measurement point, in order to extract therefrom a hot confined plasma comprising a chemical element to be quantified that is present in the targets and optionally in the probes; b) the light emission lines from the plasma are detected and analysed for each measurement point, by measuring the respective intensities of these lines; and then c) the concentration in each measurement point of the element or of a group incorporating it within the targets is determined via a prior calibration of the lines establishing a correlation between the intensities of the lines specific to the element to be quantified and given concentrations of this element.
US08486859B2 Use of ribose to enhance plant growth
The present invention relates to methods and compositions for supplementing the soil/diet of plants in order to enhance plant growth, yield, hardening, as well as the recovery of plants which undergo transplantation. The present invention provides ribose and other pentose sugars and their derivatives, alone or in combination with other carbohydrates, electrolytes, minerals, enzymes, micronutrients, macronutrients, or other ingredients to enhance plant growth, yield, hardening, and aid in the recovery during and following transplantation.
US08486858B2 Active compound combinations
The present invention relates to compositions, in particular within a fungicide composition, which comprises (A) a dithiino-tetracarboximide of formula (I) and a further fungicidally active compound (B). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and to the treated seed.
US08486856B2 Process producing activated carbon having a high catalytic activity
Process for producing activated carbon having a high catalytic activity, in which a carbonaceous material is brought into contact with nitrogen compounds, wherein the carbonaceous material is partially gasified with a mixture of steam, nitrogen and CO2 at temperatures above 800° C. in a manner known per se in a multistage fluidized bed and wherein a nitrogen compound is added into the furnace and/or at least one stage of the multistage fluidized bed.
US08486855B2 Water-absorbing polysaccharide and method for producing the same
A process for producing a polysaccharide superabsorbent particulate including the process steps of bringing into contact a polysaccharide with a polyphosphate or a polyphosphoric acid as crosslinking agent in the presence of water to form a polysaccharide gel drying the polysaccharide gel, comminuting the dried polysaccharide gel to form polysaccharide superabsorbent polymer particles, coating the particles with a polyphosphate or polyphosphoric acid, crosslinking the coated particles, and surface treating the particulate with a metal multivalent salt or an acid. The invention further relates to a polysaccharide superabsorbent polymer particulate obtainable by this process, a water-absorbent polysaccharide, a composite, a process for producing a composite, a composite produced by this process, the use of the polysaccharide superabsorbent particulates or of the composites as well as the use of polyphosphates.
US08486853B2 Exhaust gas purifying catalyst and method for manufacturing the same
An exhaust gas purifying catalyst (1) according to the present invention includes noble metal particles (6), a first compound (7) supporting the noble metal particles (6), and a second compound (9) disposed not in contact with the noble metal particles (6) and having an oxygen storage capacity. An average distance between the first compound (7) and the second compound (9) is between 5 nm and 300 nm.
US08486848B2 Laminate and article for daily use
A laminate includes a base layer being made from one of woven fabrics, knitted fabrics, and non-woven fabrics, and having two surfaces, and a thin film layer made of a polyvinyl butyral-based composition and covering one of the two surfaces of the base layer. An article for daily use, at least one part of which is made of the laminate, is also disclosed.
US08486843B2 Method of forming nanoscale three-dimensional patterns in a porous material
A method of forming a nanoscale three-dimensional pattern in a porous semiconductor includes providing a film comprising a semiconductor material and defining a nanoscale metal pattern on the film, where the metal pattern has at least one lateral dimension of about 100 nm or less in size. Semiconductor material is removed from below the nanoscale metal pattern to create trenches in the film having a depth-to-width aspect ratio of at least about 10:1, while pores are formed in remaining portions of the film adjacent to the trenches. A three-dimensional pattern having at least one nanoscale dimension is thus formed in a porous semiconductor, which may be porous silicon. The method can be extended to form self-integrated porous low-k dielectric insulators with copper interconnects, and may also facilitate wafer level chip scale packaging integration.
US08486841B2 Corrosion resistant component of semiconductor processing equipment and method of manufacture thereof
A corrosion resistant component of a plasma chamber includes a liquid crystalline polymer. In a preferred embodiment, the liquid crystalline polymer (LCP) is provided on an aluminum component having an anodized or non-anodized surface. The liquid crystalline polymer can also be provided on an alumina component. The liquid crystalline polymer can be deposited by a method such as plasma spraying. The liquid crystalline polymer may also be provided as a preformed sheet or other shape adapted to cover the exposed surfaces of the reaction chamber. Additionally, the reactor components may be made entirely from liquid crystalline polymer by machining the component from a solid block of liquid crystalline polymer or molding the component from the polymer. The liquid crystalline polymer may contain reinforcing fillers such as glass or mineral fillers.
US08486840B2 Inverse spacer processing
A method includes making a target feature of an integrated circuit by providing a main layer over a substrate, depositing a first mask layer over the main layer, patterning the first mask layer, forming sidewall spacers with a width (w) in adjoining sidewalls of the patterned first mask layer and exposing a top area of the patterned first mask layer, selectively removing the first mask layer and exposing a portion of the main layer between the sidewall spacers, depositing a second mask layer over the main layer between the sidewall spacers, selectively removing the sidewall spacers to form an opening and exposing another portion of the main layer in the opening, etching the main layer through the opening to form the target feature.
US08486837B2 Polishing slurry for metal, and polishing method
A polishing slurry for metal comprises an oxidizer, a metal oxide dissolving agent, a metal inhibitor, and water, wherein the metal inhibitor is at least one of a compound having an amino-triazole skeleton and a compound having an imidazole skeleton. The use of the polishing slurry for metal makes it possible to raise the polishing speed sufficiently while keeping the etching speed low, restrain the generation of corrosion of the surface of a metal and dishing, and form a metal-film-buried pattern having a high reliability in the process of formation of wiring of semiconductor devices.
US08486836B2 Semiconductor device and method of manufacturing the same
A semiconductor device including: a substrate; an insulating film formed over the substrate; a copper interconnect, having a plurality of hillocks formed over the surface thereof, buried in the insulating film; a first insulating interlayer formed over the insulating film and the copper interconnect; a second insulating interlayer formed over the first insulating interlayer; and an electroconductive layer formed over the second insulating interlayer, wherein the top surface of at least one hillock highest of all hillocks is brought into contact with the lower surface of the second insulating interlayer is provided.
US08486834B2 Method for manufacturing memory device
The disclosure provides a method for manufacturing a memory device, including: providing a plurality of gate structures formed on a substrate, wherein the gate structures comprise a cap layer disposed on the top of the gate structure, and each two adjacent gate structures are separated by a gap; blanketly forming a polysilicon layer on the substrate to fill the gap; performing a planarization process to the polysilicon layer, obtaining a polysilicon plug; and performing an oxidation process after the planarization process, converting a part of the polysilicon plug and a residual polysilicon layer over the gate structure to silicon oxide.
US08486832B2 Method for fabricating semiconductor device
A trench is formed in an interlayer dielectric formed on a substrate, then a barrier seed film is formed to cover the interlayer dielectric and the inner walls of the trench, and copper is embedded in the trench by electrolytic plating using the barrier seed film as an electrode. The barrier seed film is a single-layer film made of an oxide or nitride of a refractory metal and contains a low-resistance metal other than copper.
US08486823B2 Methods of forming through via
A through via process is performed on a semiconductor substrate with a contact plug formed in an interlayer dielectric (ILD), and then a via plug is formed in the ILD layer to extend through a portion of the semiconductor substrate, followed forming an interconnection structure electrically connected with the contact plug and the via plug.
US08486819B2 Semiconductor device and method of manufacturing the same
A semiconductor device includes a gate metal buried within a trench included in a semiconductor substrate including an active region defined by an isolation layer, a spacer pattern disposed on an upper portion of a sidewall of a gate metal, a first gate oxide layer disposed between the spacer pattern and the trench, a second gate oxide layer disposed below the first gate oxide layer and the gate metal, and a junction region disposed in the active region to overlap the first gate oxide layer.
US08486814B2 Wafer backside defectivity clean-up utilizing selective removal of substrate material
A wafer and a fabrication method include a base structure including a substrate for fabricating semiconductor devices. The base structure includes a front side where the semiconductor devices are formed and a back side opposite the front side. An integrated layer is formed in the back side of the base structure including impurities configured to alter etch selectivity relative to the base structure such that the integrated layer is selectively removable from the base structure to remove defects incurred during fabrication of the semiconductor devices.
US08486810B2 Method for fabricating a substrate provided with two active areas with different semiconductor materials
A layer of second semiconductor material is deposited on the layer of first semiconductor material of a substrate. Two active areas are then defined by means of selective elimination of the first and second semiconductor materials. One of the two active areas is then covered by a protective material. The layer of second semiconductor material is then eliminated by means of selective elimination of material. A first active area comprising a main surface made from a first semiconductor material, and a second active area comprising a main surface made from second semiconductor material are thus obtained.
US08486809B2 Method for forming laminated resin film and method for producing semiconductor device
A method for producing a semiconductor device includes the steps of forming a semiconductor layer; forming a non-silicon-containing resin layer on the semiconductor layer; forming a pattern in the non-silicon-containing resin layer; forming a silicon-containing resin layer on the non-silicon-containing resin layer; etching the silicon-containing resin layer; selectively etching the non-silicon-containing resin layer; and etching the semiconductor layer. The step of forming the silicon-containing resin layer includes the steps of applying a silicon-containing resin solution with a first viscosity on a surface of the non-silicon-containing resin layer, the silicon-containing resin solution containing a silicon-containing resin and a volatile solvent; heating the silicon-containing resin layer to a first temperature, the silicon-containing resin layer having a second viscosity by heating to the first temperature, the second viscosity being larger than the first viscosity; and applying a rinse solution containing a volatile component to an edge portion of the silicon-containing resin layer.
US08486807B2 Realizing N-face III-nitride semiconductors by nitridation treatment
A method of forming a semiconductor structure includes providing a substrate; forming a buffer/nucleation layer over the substrate; forming a group-III nitride (III-nitride) layer over the buffer/nucleation layer; and subjecting the III-nitride layer to a nitridation. The step of forming the III-nitride layer comprises metal organic chemical vapor deposition.
US08486806B2 Method for machining wafers by cutting partway through a peripheral surplus region to form break starting points
A wafer having a device region and a peripheral surplus region surrounding the device region is divided into individual devices. The back side of the device region is ground to form an annular reinforcement part on the outer peripheral side thereof. A dicing tape is adhered to the back side of the wafer, and the wafer is irradiated with a laser beam from the face side so as to divide the wafer into the devices and to form break starting points in the annular reinforcement part. The dicing tape is expanded so as to disassemble the annular reinforcement part, with the break starting points as starting points, thereby separating the annular reinforcement part from the device region, and widening the interval between the adjacent devices. Since the annular reinforcement part is intact when the wafer is divided, handleability during the divided process is not spoiled.
US08486802B2 Method of manufacturing semiconductor device having shared bit line structure
A semiconductor device, including a substrate having first and second active regions, the first and second active regions being disposed on opposite sides of an isolation structure, and a bit line electrically coupled to a contact plug that is on the isolation structure between the first active region and the second active region, and electrically coupled to an active bridge pattern directly contacting at least one of the first and second active regions, wherein the contact plug is electrically coupled to the first active region and the second active region, and a bottom surface of the active bridge pattern is below a top surface of the first and second active regions.
US08486801B2 Fabricating method of DRAM structure
A fabricating method of a DRAM structure includes providing a substrate comprising a memory array region and a peripheral region. A buried gate transistor is disposed within the memory array region, and a planar gate transistor is disposed within the peripheral region. Furthermore, an interlayer dielectric layer covers the memory array region, the buried gate transistor and the planar gate transistor. Then, a capping layer of the planar gate transistor and part of the interlayer dielectric layer are removed simultaneously so that a first contact hole, a second contact hole and a third contact hole are formed in the interlayer dielectric layer. A drain doping region of the buried gate transistor is exposed through the first contact hole, a doping region of the planar gate transistor is exposed through the second contact hole, and a gate electrode of the planar gate transistor is exposed through the third contact hole.
US08486794B1 Method for manufacturing semiconductor structure
A method for manufacturing a semiconductor structure is provided. The method includes following steps. A patterned gate layer is formed on a semiconductor substrate. A compensation layer is formed on the semiconductor substrate outside the patterned gate layer. A trench is formed in the compensation layer and the semiconductor substrate. An epitaxial layer is formed in the trench. The step for forming the compensation layer is between the step for forming the patterned gate layer and the step for forming the epitaxial layer.
US08486791B2 Mufti-layer single crystal 3D stackable memory
Technology is described herein for manufacturing a three-dimensional 3D stacked memory structure having multiple layers of single crystal silicon or other semiconductor. The multiple layers of single crystal semiconductor are suitable for implementing multiple levels of high performance memory cells.
US08486785B2 Surround gate CMOS semiconductor device
The semiconductor device includes: a columnar silicon layer on the planar silicon layer; a first n+ type silicon layer formed in a bottom area of the columnar silicon layer; a second n+ type silicon layer formed in an upper region of the columnar silicon layer; a gate insulating film formed in a perimeter of a channel region between the first and second n+ type silicon layers; a gate electrode formed in a perimeter of the gate insulating film, and having a first metal-silicon compound layer; an insulating film formed between the gate electrode and the planar silicon layer, an insulating film sidewall formed in an upper sidewall of the columnar silicon layer; a second metal-silicon compound layer formed in the planar silicon layer; and an electric contact formed on the second n+ type silicon layer.
US08486784B2 Vertical semiconductor device and method of manufacturing the same
A vertical semiconductor device with improved junction profile and a method of manufacturing the same are provided. The vertical semiconductor device includes a pillar vertically extended from a surface of a semiconductor substrate, a silicon layer formed in a bit line contact region of one sidewall of the pillar, and a junction region formed within a portion of the pillar contacting with the silicon layer.
US08486777B2 Method for manufacturing microcrystalline semiconductor and thin film transistor
A technique for manufacturing a microcrystalline semiconductor layer with high mass productivity is provided. In a reaction chamber of a plasma CVD apparatus, an upper electrode and a lower electrode are provided in almost parallel to each other. A hollow portion is formed in the upper electrode, and the upper electrode includes a shower plate having a plurality of holes formed on a surface of the upper electrode which faces the lower electrode. A substrate is provided over the lower electrode. A gas containing a deposition gas and hydrogen is supplied to the reaction chamber from the shower plate through the hollow portion of the upper electrode, and a rare gas is supplied to the reaction chamber from a portion different from the upper electrode. Accordingly, high-frequency power is supplied to the upper electrode to generate plasma, so that a microcrystalline semiconductor layer is formed over the substrate.
US08486774B2 Thin film transistor and display device
A thin film transistor is provided that includes a gate electrode, a source electrode, and a drain electrode, an oxide semiconductor active layer formed over the gate electrode, a fixed charge storage layer formed over a portion of the oxide semiconductor active layer, and a fixed charge control electrode formed over the fixed charged storage layer.
US08486773B2 Semiconductor device and manufacturing method thereof
A semiconductor film having an impurity region to which at least an n-type or p-type impurity is added and a wiring are provided. The wiring includes a diffusion prevention film containing a conductive metal oxide, and a low resistance conductive film over the diffusion prevention film. In a contact portion between the wiring and the semiconductor film, the diffusion prevention film and the impurity region are in contact with each other. The diffusion prevention film is formed in such a manner that a conductive film is exposed to plasma generated from a mixed gas of an oxidizing gas and a halogen-based gas to form an oxide of a metal material contained in the conductive film, the conductive film in which the oxide of the metal material is formed is exposed to an atmosphere containing water to be fluidized, and the fluidized conductive film is solidified.
US08486771B2 Methods of forming relaxed layers of semiconductor materials, semiconductor structures, devices and engineered substrates including same
Methods of fabricating relaxed layers of semiconductor materials include forming structures of a semiconductor material overlying a layer of a compliant material, and subsequently altering a viscosity of the compliant material to reduce strain within the semiconductor material. The compliant material may be reflowed during deposition of a second layer of semiconductor material. The compliant material may be selected so that, as the second layer of semiconductor material is deposited, a viscosity of the compliant material is altered imparting relaxation of the structures. In some embodiments, the layer of semiconductor material may comprise a III-V type semiconductor material, such as, for example, indium gallium nitride. Methods of fabricating semiconductor structures and devices are also disclosed. Novel intermediate structures are formed during such methods. Engineered substrates include a plurality of structures comprising a semiconductor material disposed on a layer of material exhibiting a changeable viscosity.
US08486763B2 Method for thinning and dicing electronic circuit wafers
A method for thinning and dicing a wafer of electronic circuits, wherein: a thinning step is carried out while the wafer is supported by a first film bonded at the periphery of a support frame; and a dicing step is carried out while the thinned wafer is supported by a second film bonded at the periphery of the same frame from the other surface of the wafer, the first film being unstuck only once the second one is in place.
US08486761B2 Hybrid combination of substrate and carrier mounted light emitting devices
A multi-chip light emitting device (LED) uses a low-cost carrier structure that facilitates the use of substrates that are optimized to support the devices that require a substrate. Depending upon the type of LED elements used, some of the LED elements may be mounted on the carrier structure, rather than on the more expensive ceramic substrate. In like manner, other devices, such as sensors and control elements, may be mounted on the carrier structure as well. Because the carrier and substrate structures are formed independent of the encapsulation and other after-formation processes, these structures can be tested prior to encapsulation, thereby avoiding the cost of these processes being applied to inoperative structures.
US08486760B2 Method of manufacturing substrate for flip chip and substrate for flip chip manufactured using the same
There is provided a method of manufacturing a substrate for flip chip, and a substrate for flip chip manufactured using the same. The method includes providing a base substrate including at least one conductive pad, forming a solder resist layer on the base substrate, the solder resist layer including a first opening exposing the conductive pad, forming a dry film on the solder resist layer, the dry film including a second opening connected with the first opening, forming a metal post in the first opening and a part of the second opening, filling the second opening above the metal post with solder paste, forming a solder cap by performing a reflow process on the filled solder paste, planarizing a surface of the solder cap, and removing the dry film. Accordingly, fine pitches and improve reliability can be achieved.
US08486749B2 Micro/nanostructure PN junction diode array thin-film solar cell and method for fabricating the same
The present invention discloses a micro/nanostructure PN junction diode array thin-film solar cell and a method for fabricating the same, wherein a microstructure or sub-microstructure PN junction diode array, such as a nanowire array or a nanocolumns array, is transferred from a source-material wafer to two pieces of transparent substrates, which are respectively corresponding to two electric conduction types, to fabricate a thin-film solar cell. In the present invention, the micro/nanostructure PN junction diode array has advantages of a fine-quality crystalline semiconductor, and the semiconductor substrate can be reused to save a lot of semiconductor material. Besides, the present invention can make the best of sunlight energy via stacking up the solar cells made of different types of semiconductor materials to absorb different wavebands of the sunlight spectrum.
US08486748B2 Method for manufacturing solid-state imaging device
A solid-state imaging device having a light-receiving section that photoelectrically converts incident light includes an insulating film formed on a light-receiving surface of the light-receiving section and a film and having negative fixed charges formed on the insulating film. A hole accumulation layer is formed on a light-receiving surface side of the light-receiving section. A peripheral circuit section in which peripheral circuits are formed is provided on a side of the light-receiving section. The insulating film is formed between a surface of the peripheral circuit section and the film having negative fixed charges such that a distance from the surface of the peripheral circuit section to the film having negative fixed charges is larger than a distance from a surface of the light-receiving section to the film having negative fixed charges.
US08486747B1 Backside silicon photovoltaic cell and method of manufacturing thereof
Proposed is the backside silicon photovoltaic cell and method for forming backside selective emitters, backside doped base contact regions, backside field-induced emitters, FSF-regions, and contacts to the functional regions of a backside solar cell by essentially electrical means and without conventional thermal diffusion and masking processes. The process includes forming conductive layers on both sides of an intermediate device structure, performing Joule heating by passing electrical current through the backside conductive layers thus forming the selective emitters, the base contact regions, and contacts to the functional regions. The obtained structure is then subjected to pulse electrical treatment by applying a voltage pulse or pulses between the front and back conductive layers to form the field-induced emitter and the field-induced FSF. After the conductive layers are removed, a final solar cell is obtained. The proposed method can significantly simplify manufacturing, reduce cost, and increase throughput in the field of semiconductor fabrication.
US08486746B2 Thin silicon solar cell and method of manufacture
A method of fabricating a solar cell is disclosed. The method includes the steps of forming a sacrificial layer on a silicon substrate, forming a doped silicon layer atop the sacrificial substrate, forming a silicon film atop the doped silicon layer, forming a plurality of interdigitated contacts on the silicon film, contacting each of the plurality of interdigitated contacts with a metal contact, and removing the sacrificial layer.
US08486745B2 Multi-terminal phase change devices
Phase change devices, and particularly multi-terminal phase change devices, include first and second active terminals bridged together by a phase-change material whose conductivity can be modified in accordance with a control signal applied to a control electrode. This structure allows an application in which an electrical connection can be created between the two active terminals, with the control of the connection being effected using a separate terminal or terminals. Accordingly, the resistance of the heater element can be increased independently from the resistance of the path between the two active terminals. This allows the use of smaller heater elements thus requiring less current to create the same amount of Joule heating per unit area. The resistance of the heating element does not impact the total resistance of the phase change device. The programming control can be placed outside of the main signal path through the phase change device, reducing the impact of the associated capacitance and resistance of the device.
US08486744B2 Multiple bonding in wafer level packaging
The present disclosure provides a method for fabricating a MEMS device including multiple bonding of substrates. In an embodiment, a method includes providing a micro-electro-mechanical systems (MEMS) substrate including a first bonding layer, providing a semiconductor substrate including a second bonding layer, and providing a cap including a third bonding layer. The method further includes bonding the MEMS substrate to the semiconductor substrate at the first and second bonding layers, and bonding the cap to the semiconductor substrate at the second and third bonding layers to hermetically seal the MEMS substrate between the cap and the semiconductor substrate. A MEMS device fabricated by the above method is also provided.
US08486743B2 Methods of forming memory cells
Some embodiments include methods of forming memory cells. Programmable material may be formed directly adjacent another material. A dopant implant may be utilized to improve adherence of the programmable material to the other material by inducing bonding of the programmable material to the other material, and/or by scattering the programmable material and the other material across an interface between them. The memory cells may include first electrode material, first ovonic material, second electrode material, second ovonic material and third electrode material. The various electrode materials and ovonic materials may join to one another at boundary bands having ovonic materials embedded in electrode materials and vice versa; and having damage-producing implant species embedded therein. Some embodiments include ovonic material joining dielectric material along a boundary band, with the boundary band having ovonic material embedded in dielectric material and vice versa.
US08486739B2 Etchant for etching double-layered copper structure and method of forming array substrate having double-layered copper structures
An etchant for forming double-layered signal lines and electrodes of a liquid crystal display device includes hydrogen peroxide (H2O2), a phosphate, F-ions, an organic acid having a carboxyl group (—COOH), a copper (Cu) inhibitor, and a hydrogen peroxide (H2O2) stabilizer, wherein each of the double-layered signal lines and electrodes of the liquid crystal display device includes a first layer of one of aluminum (Al), aluminum alloy (Al-alloy), titanium (Ti), titanium alloy (Ti-alloy), tantalum (Ta), and a tantalum alloy (Ta-alloy) and a second layer of copper (Cu).
US08486734B2 Alternating current light-emitting device and fabrication method thereof
An alternating current light-emitting device includes a substrate, a plurality of microdie light-emitting elements formed on the substrate, a rectifying element-dedicated member formed on a surface of a portion of microdie light-emitting elements, a rectifying unit formed on the rectifying element-dedicated member and provided with at least four rectifying elements forming a Wheatstone bridge circuit, and an electrically conductive structure electrically connecting the rectifying elements and the microdie light-emitting elements. With the rectifying unit being formed on the rectifying element-dedicated member, the rectifying elements are highly tolerant of reverse bias and feature low starting forward bias. Also, the present invention provides a method for fabricating an alternating current light-emitting device.
US08486730B2 Method of separating light-emitting diode from a growth substrate
A method of forming a light-emitting diode (LED) device and separating the LED device from a growth substrate is provided. The LED device is formed by forming an LED structure over a growth substrate. The method includes forming and patterning a mask layer on the growth substrate. A first contact layer is formed over the patterned mask layer with an air bridge between the first contact layer and the patterned mask layer. The first contact layer may be a contact layer of the LED structure. After the formation of the LED structure, the growth substrate is detached from the LED structure along the air bridge.
US08486726B2 Method for improving performance of a substrate carrier
A method of modifying a substrate carrier to improve process performance includes depositing material or fabricating devices on a substrate supported by a substrate carrier. A parameter of layers deposited on the substrate is then measured as a function of their corresponding positions on the substrate carrier. The measured parameter of at least some devices fabricated on the substrate or a property of the deposited layers is related to a physical characteristic of substrate carrier to obtain a plurality of physical characteristics of the substrate carrier corresponding to a plurality of positions on the substrate carrier. The physical characteristic of the substrate carrier is then modified at one or more of the plurality of corresponding positions on the substrate carrier to obtain desired parameters of the deposited layers or fabricated devices as a function of position on the substrate carrier.
US08486724B2 Wafer level reflector for LED packaging
An optical emitter is fabricated by bonding a Light-Emitting Diode (LED) die to a package wafer, electrically connecting the LED die and the package wafer, forming a phosphor coating over the LED die on the package wafer, molding a lens over the LED die on the package wafer, molding a reflector on the package wafer, and dicing the wafer into at least one optical emitter.
US08486720B2 Arrays of magnetic particles
The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub-libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
US08486719B2 Multiplex assay methods and compositions
Luminescence assays and compositions for assay of biomolecular interaction and activity and detection of modulators of biomolecular interaction and activity are provided. Technology described herein has utility in a variety of assay formats and types, for example, simultaneous monitoring multiple parameters which affect interaction and activity of biological molecules. Compositions and methods are provided herein which include a first solid-phase support associated with a first specific binding agent and a photosensitizer; a second solid-phase support associated with a second specific binding agent and a first emission system; and a third solid-phase support associated with a third specific binding agent and a second emission system.
US08486715B2 Dispensing of a diagnostic liquid onto a diagnostic reagent
Biological fluid samples are deposited by methods that produce a uniform layer of the sample over a reagent-containing surface. In one embodiment, a nozzle having multiple openings is used to deposit a sample over the reagent-containing surface simultaneously. In an alternative embodiment, single droplets of the sample are deposited in a pattern on the surface, preferably in a sequence of parallel lines. The reaction between the biological sample and the reagents is read from a spectrographic image of the reagent-containing surface obtained by optical methods.
US08486714B2 Reagent delivery system, dispensing device and container for a biological staining apparatus
The invention concerns reagent delivery system for an apparatus for processing of biological samples arranged on microscope slides, comprising a reagent section having one or more reagent containers; a slide section in which at least one microscope slide is arranged; a probe for dispensing a portion of reagent onto a predetermined microscope slide, and means for handling the probe. The probe comprises a continuous prove tubing element extending through a rigid probe member and connecting the probe tip to a pneumatic pressure regulation device. The reagent containers are adapted for cooperation with the probe tip. In this manner a high though-put and a very low carry over of fluid residues is achieved since there is no assembled parts making up the inside volume of the probe in which the fluid may be retained.
US08486712B2 Deuterium isobaric tag reagents for quantitative analysis
Deuterium isobaric tag reagents are provided for the quantitation of biomolecules, where the reagents contain heavy isotope atoms, including one or more 2H in each reagent. Generally, the reagents are described by the formula: reporter group—balancer group—reactive group, wherein the reporter group and the balancer group are linked by an MS/MS scissionable bond. Each of the reporter group and balancer groups independently contain 0 to 9 heavy isotope atoms selected from 13C, 15N and 2H and the total number of 2H atoms in each reagent is 1 to 6. The mass of the reporter group is from 114-123 Daltons. Exemplary deuterium isobaric tag reagents include Di-ART, DiART-t-I, DiART-t-Br and DiART-t-M. Also provided are compositions containing more than one deuterium isobaric tag reagent and methods for making and using deuterium isobaric tag reagents.
US08486710B2 Method, sensor and system for measuring a lower heating value and a Wobbe Index of a gaseous fuel
A method for measuring a lower heating value of a gaseous fuel. The method includes mixing a gaseous fuel with air to provide a combustible air-fuel mixture. The air-fuel mixture is directed to flow across a flow surface of a first micro-hotplate maintained at a constant temperature. A change in power required to maintain a constant temperature of the first micro-hotplate flow surface due to a convective and conductive heat transfer from the first micro-hotplate flow surface to the air-fuel mixture is measured. The air-fuel mixture is directed to flow across a flow surface of a second micro-hotplate maintained at a constant temperature. The air-fuel mixture is combusted as the air-fuel mixture flows across the second micro-hotplate flow surface. A change in power required to maintain a constant temperature of the second micro-hotplate flow surface due to the combustion of the air-fuel mixture is measured.
US08486707B2 Method of oligonucleotide sequencing by mass spectrometry
A computer-implemented method for confirming the nucleotide sequence of an oligonucleotide is provided. In certain embodiments, the method comprises: a) inputting the nucleotide sequence of an oligonucleotide; b) executing an algorithm that provides the predicted molecular formulas of fragments of the oligonucleotide; c) comparing the predicted m/z values of the predicted molecular formulas to experimentally-obtained m/z values obtained by analysis of the oligonucleotide by tandem mass spectrometry to determine if the predicted masses correspond with the experimentally-obtained masses. The method may be used, for example, to confirm the identity of an oligonucleotide after it is synthesized.
US08486705B2 Method of characterizing a heparin-like glycosaminoglycan mixture of interest
The invention provides methods and apparatus for characterizing complex polymeric mixture of interest. Candidate solutions are eliminated from a solution space using one or more experimental measurements of a polymeric mixture of interest. The elimination step can be repeated one or more times using different experimental measurements produced by various chemical and physical protocols, so that the remaining candidate solutions converge to describe the actual polymeric mixture under investigation. Once the composition of the complex polymeric mixture has been characterized, the information thus generated can be used to facilitate, for example, the manufacture of a bio-equivalent of the complex polymeric mixture.
US08486703B2 Surface sampling concentration and reaction probe
A method of analyzing a chemical composition of a specimen is described. The method can include providing a probe comprising an outer capillary tube and an inner capillary tube disposed co-axially within the outer capillary tube, where the inner and outer capillary tubes define a solvent capillary and a sampling capillary in fluid communication with one another at a distal end of the probe; contacting a target site on a surface of a specimen with a solvent in fluid communication with the probe; maintaining a plug volume proximate a solvent-specimen interface, wherein the plug volume is in fluid communication with the probe; draining plug sampling fluid from the plug volume through the sampling capillary; and analyzing a chemical composition of the plug sampling fluid with an analytical instrument. A system for performing the method is also described.
US08486701B2 ETS2 and MESP1 generate cardiac progenitors from fibroblasts
A method for modulating cell differentiation capabilities using heterologous gene expression. Some embodiments of the invention relate to a method for inducing a cardiac progenitor cell by delivering a reprogramming factor to the cell, wherein the reprogramming factor comprises ETS2 or a combination of ETS2 and Mesp1.
US08486695B2 Mesenchymal stem cells expressing TNF-alpha receptors
Mesenchymal stem cells which express TNF-α receptor Type I in an amount of at least 13 pg/106 cells. Such mesenchymal stem cells inhibit the proliferation of lymphocytes and may be employed, in particular, in the treatment of graft-versus-host disease.
US08486692B2 Cell culture apparatus and associated methods
A cell culture apparatus consists of a vessel or array of vessels, each comprising a substantially flat bottom and substantially vertical sides, and composed of a substantially gas permeable material. The inner bottom surface of the vessel is commonly textured to provide the cells with adequate features for attachment and spreading. The vessel may include an integral annular flange which can be used to suspend the vessel from a suspensory element of a rack structure. To promote cell attachment and growth, the inner surfaces of the vessel bottom and sides may be coated with commonly available bio-active materials. Cells cultured in the system commonly grow in three dimensions for extended periods of time, and often produce significantly higher quantities of cellular products than cells grown in conventional labware.
US08486682B2 β-amylase, gene coding therefor and manufacturing method thereof
To provide novel β-amylase derived from a microorganism and a gene thereof. β-amylase derived from Bacillus flexus is provided.
US08486680B2 Xylanases, nucleic acids encoding them and methods for making and using them
The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo-β-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.
US08486673B2 Method for producing 1,3-propanediol using crude glycerol, a by-product from biodiesel production
The invention discloses a method for producing 1,3-propanediol, comprising the steps of: using crude glycerol, a by-product during the biodiesel production, without further treatment, as the substrate for production of 1,3-propanediol; inoculating a 1,3-propanediol-producing strain in a seed medium containing crude glycerol, a by-product from biodiesel production; adding the seed culture into a fermentation medium containing crude glycerol, a by-product from biodiesel production, and fermenting; maintaining pH in a range of 6.8 to 8.0; and in the end of the fermentation, isolating and purifying 1,3-propanediol.
US08486672B2 Method of producing lauric acid or an ester thereof
To provide a method for supplying lauric acid with algae.The method for producing an oil or fat containing lauric acid as a constituent fatty acid includes culturing algae in the class Chlorarachniophyceae in a medium and recovering, from the culture product, an oil or fat having a lauric acid content of 3 weight % or higher of the fatty acid composition.
US08486667B2 EGVII endoglucanase and nucleic acids encoding the same
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVII, recombinant EGVII proteins and methods for producing the same.
US08486666B2 Removal of the guanine cap on the 5′ terminus of RNA
Methods and compositions are provided for efficiently removing a guanine cap from the 5′ end of an RNA using enzymes. Decapped RNA can be used for cloning, sequencing or other RNA manipulations.
US08486661B2 Polynucleotides encoding antibodies against sclerostin and uses therefor
The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat a pathological disorder that is mediated by sclerostin or disease related to bone abnormalities such as osteoporosis.
US08486654B2 Compositions and methods for measuring 3,6-L-AHG transferase activity and 3,6-L-AHG
Provided herein are a composition for measuring 3,6-anhydro-L-galactose (3,6-L-AHG) transferase activity by reduction of NADP to NADPH, and a method of measuring 3,6-L-AHG transferase activity using the same. The composition and method are useful for determining 3,6-L-AHG in a material containing 3,6-L-AHG such as algae biomass and industrial applications.
US08486653B2 Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins
An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.
US08486652B2 Method for the in vitro diagnosis of stroke
A method for the in vitro diagnosis of stroke and transient ischemic attack (TIA) in an individual, including the following steps: (a) measuring the level of proBNP(1-108), or of fragments of proBNP(1-108) including a RAPRSP sequence (SEQ ID NO: 1), in a biological sample of the individual; (b) measuring the level of nucleoside diphosphate kinase A (NDKA) in a biological sample of the individual; (c) comparing the level of proBNP(1-108), or of fragments of proBNP(1-108), and the level of NDKA, with one or several cut-off values; and (d) determining therefrom whether a stroke or a TIA has occurred in the individual.
US08486648B2 Methods of detecting ovarian cancer
The present invention provides methods of detecting ovarian cancer using biomarkers.
US08486645B2 Gene defects and mutant ALK kinase in human solid tumors
Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant polypeptides, probes for detecting it, isolated mutant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The invention also provides methods for determining the presence of these mutant polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides.
US08486642B2 Method of synthesizing 1,3-cyclohexadione derived reagents useful for detection or isolation of sulfenic acid-containing compounds
The present invention provides a method of synthesizing compounds of Formula I: wherein: R1 is a label (e.g., a detectable groups; an anti-tumor agents); L is present or absent and when present is a linking group; and x represents an integer from 1 to 10; or a pharmaceutically acceptable salt thereof. the compounds are useful for, among other things, identifying cysteine sulfenic acids in proteins and monitoring oxidative damage in proteins and cells.
US08486639B2 Nanoassembled complexes of nucleic acids, avidin and polymers, use and preparation thereof
The present invention discloses new nanoassembled complexes consisting of a central nucleus formed by a high-affinity interaction from nucleic acids and avidin, wherein said nucleus is stabilized in aqueous solutions, even saline, and protected from further unspecific unwanted interactions by means of suitable polymeric agents capable to mask totally or partially the nucleus itself. The nanocomplexes obtained have been shown to be stable in aqueous solutions and to have nanoparticle features. In addition, the nano-complexes have shown characteristics useful for use in biotechnological field and in nanomedicine.
US08486637B2 Methods and reagents for the detection of Salmonella spp
The invention relates to an in vitro method for the detection of bacteria of the Salmonella spp. genus by means of a quantitative polymerase chain reaction using specific primers for the pathogen from DNA and RNA samples from the microorganism. The method is useful in the detection of viable and non-viable microorganisms of Salmonella spp. in environmental, clinical and food samples. Likewise, the invention also relates to a kit used for putting the method into practice.
US08486634B2 Amplifying bisulfite-treated template
Methods of amplifying nucleic acid are described. Primers on solid support, e.g. a population of beads, are employed. A population of nucleic acid template molecules, wherein the nucleic acid template molecules have been treated with bisulfite, is amplified so as to create loaded beads comprising amplified nucleic acid.
US08486633B2 Method for detecting nucleic acid sequences
The invention is directed to a method for detecting a target nucleic acid sequence by non-linear amplification.
US08486629B2 Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
Disclosed are methods of for constructing a bead-displayed library of oligonucleotide probes (or sequence-modified capture moieties such as protein-nucleic acid conjugates) by ligation of a capture probe, having an analyte-specific sequence, to an anchor probe that is attached, at its 5′-end, (or possibly at the 3′ end) to an encoded carrier such as a color-coded microparticle (“bead”). Such a library can also be constructed by elongation of an anchor probe, using a second probe as the elongation template, wherein the second probe has an anchor-specific subsequence and an analyte-specific subsequence.
US08486623B2 Releasable nonvolatile mass-label molecules
Releasable tag reagents for use in the detection and analysis of target molecules, particular in mass spectrometric analyzes are provided. Also provided are methods of detection that employ releasable tag reagents.
US08486619B2 Arrayed imaging reflectometry (air) sensor chip comprising influenza hemagglutinin (HA) polypeptides suitable for the detection of antiviral immune responses
A sensor chip for detecting an immune response against an influenza virus, the sensor chip including a substrate having a surface and a plurality of hemagglutinin polypeptides bound to discrete locations on the surface of the substrate, each hemagglutinin polypeptide having a hemagglutinin epitope. Detection devices containing the sensor chip and methods of detecting influenza immune responses are also described herein.
US08486617B2 Methods for preparing freeze-dried platelets, compositions comprising freeze-dried platelets, and methods of use
The present invention provides processes for preparing freeze-dried platelets, freeze-dried platelets made by those processes, platelets reconstituted from those freeze-dried platelets, methods of using the platelets for therapeutic, diagnostic, and research purposes, and kits comprising the freeze-dried platelets.
US08486614B2 Device and method for exposing a photo material
The invention relates to a method and an imagesetter by means of which a photo material comprising a plurality of zones to be exposed individually, such as hundreds of thousands of such zones, can be done in an economical manner and particularly in acceptable exposure times. To this end, a method is provided for exposing a photo material comprising a plurality of zones to be exposed, preferably disposed regularly, particularly line by line, and having a digitally derived image, by means of which method a continuous relative motion is carried out between the photo material and the imagesetter, and the exposition of the individual zones takes place during said motion.
US08486611B2 Semiconductor constructions and methods of forming patterns
Some embodiments include methods of forming patterns. A semiconductor substrate is formed to comprise an electrically insulative material over a set of electrically conductive structures. An interconnect region is defined across the electrically conductive structures, and regions on opposing sides of the interconnect region are defined as secondary regions. A two-dimensional array of features is formed over the electrically insulative material. The two-dimensional array extends across the interconnect region and across the secondary regions. A pattern of the two-dimensional array is transferred through the electrically insulative material of the interconnect region to form contact openings that extend through the electrically insulative material and to the electrically conductive structures, and no portions of the two-dimensional array of the secondary regions is transferred into the electrically insulative material.
US08486609B2 Antireflective coating composition and process thereof
The invention relates to an antireflective coating composition comprising a crosslinker and a crosslinkable polymer capable of being crosslinked by the crosslinker, where the crosslinkable polymer comprises a unit represented by structure (1): A-Bn  (1) where A is a fused aromatic ring and B has a structure (2), where R1 is C1-C4alkyl and R2 is C1-C4alkyl. The invention further relates to a process for forming an image using the composition.
US08486608B2 Printing substrate for liquid crystal display, and manufacturing method thereof
The present invention relates to the implementation of minute patterns and thus improving pattern resolution and transcription property. Provided is a printing substrate for a liquid crystal display comprising a transparent insulating substrate, and a material layer for dry etching formed on an upper surface of the transparent insulating substrate, the material layer for dry etching constituting a printing pattern, and a manufacturing method of a printing substrate for a liquid crystal display comprising forming a material layer on a transparent insulating substrate, applying a photo resist along a printing pattern on the upper side of the material layer, dry-etching the material layer along the printing pattern using the photo resist as an etching mask, and striping the photo resist.
US08486604B2 Positive-type radiation-sensitive composition, cured film, interlayer insulating film, method of forming interlayer insulating film, display device, and siloxane polymer for forming interlayer insulating film
The present invention provides a positive-type radiation-sensitive composition containing (A) a siloxane polymer, and (B) a quinone diazide compound, in which the content of aryl groups relative to Si atoms in the siloxane polymer (A) is greater than 60% by mole and no greater than 95% by mole.
US08486603B2 Method for producing toner block
There is provided a method for producing a toner block. The method includes: preparing a toner suspension in which toner particles are dispersed in water so that the toner suspension is a dilatant fluid; preparing an aggregate of the toner particles in a form of cake by absorbing water contained in the toner suspension by a water absorptive material; and drying the aggregate.
US08486602B2 Toner particles and cold homogenization method
A method of making toner particles, including cold homogenizing at a temperature below room temperature a resin emulsion, a colorant, an optional wax, and optional additives with a coagulant to form a toner slurry; heating the toner slurry to form aggregated toner particles; freezing aggregation of the particles in the slurry once at a desired aggregated particle size; and further heating the aggregated particles in the slurry to coalesce the aggregated particles into toner particles.
US08486601B2 Toner for electrostatic latent image development and image forming method
A toner for electrostatic latent image development is disclosed comprising colored particles containing a binder resin and a colorant and external-additive particles attached to the surfaces of the colored particles, wherein the external-additive particles comprise resin particles covered with an inorganic layer, and the resin particles are bound to the inorganic layer by a siloxane bond. A preparation method of the toner is also disclosed.
US08486599B2 Developer and image forming apparatus
According to an embodiment, provided is a developer, which is used for a full-color image forming apparatus, wherein the developer includes a monochrome toner and a color toner, each including a coloring material, an amorphous polyester resin, a crystalline polyester resin, and an ester wax which includes ester compounds having an alkyl group and also having a carbon number of from 32 to 48, the amorphous polyester resin to be blended in the monochrome toner has a melting point (Tm2) of from 140 to 155° C. and the amorphous polyester resin to be blended in the color toner has a melting point (Tm1) of from 115 to 130° C., and the Tm1 and the Tm2 satisfy the following formula (1): 10(° C.)≦Tm2−Tm1≦40(° C.).
US08486598B2 Electrophotographic toner
An electrophotographic toner contains an electron donating color former compound, an electron accepting color developing agent, and a polyester binder resin having a weight average molecular weight Mw of 6000 or more and 25000 or less, and the toner is decolorized by heating.
US08486596B2 Toner, image forming method, and process cartridge
A toner produced by a method including dissolving or dispersing toner components comprising a colorant and at least one of a binder resin and a precursor thereof in an organic solvent to prepare a toner components liquid, dispersing the toner components liquid in an aqueous medium including a surfactant, a particulate resin A having the same polarity as the surfactant and a volume average particle diameter of from 5 to 50 nm, and a particulate resin B having a volume average particle diameter of from 10 to 500 nm to form liquid droplets, and removing the organic solvent from the liquid droplets. The particulate resin B is incompatible with the binder resin and swells in the organic solvent.
US08486592B2 Nanoparticle dispersion to improve radiation sensitivity
A radiation-sensitive material comprising a support and a radiation sensitive composition on the support is disclosed, wherein the radiation sensitive composition includes a dispersion containing nanoparticles of a sensitizer.
US08486591B2 Photosensitive resin composition for color filter and color filter prepared using the same
Disclosed is a color filter photosensitive resin composition that includes (A) an acryl-based binder resin having at least one carboxyl group, (B) an acryl-based photopolymerizable monomer, (C) a photopolymerization initiator, and (D) a solvent, where at least one of the acryl-based binder resin or the acryl-based photopolymerizable monomer includes a blue dye functional group. The color filter photosensitive resin composition can be prepared into a color filter having uniformity, almost no residue, and high resolution due to ultrafine pixels of 1.4 μm or less.
US08486589B2 Lithographic processing method, and device manufactured thereby
A method of splitting a lithographic pattern into two sub-patterns, includes generating test structures corresponding to structures of interest in the lithographic pattern, varying the test structures through a selected range of dimensions, simulating an image of the test structures, determining an image quality metric for the simulated image, analyzing the determined image quality metric to determine pitch ranges for which split improves the image quality metric and ranges for which split does not improve the image quality metric, and generating the two sub-patterns in accordance with the determined pitch ranges.
US08486581B2 Fuel cartridge, fuel cell system, and power management method thereof
A fuel cartridge includes a plurality of chambers and a plurality of supply devices. Each of the chambers is capable of storing a first reactant. The supply devices are respectively corresponding to the chambers; and each of the supply devices is capable of supplying a second reactant to the corresponding chamber so that the second reactant reacts with the first reactant in the corresponding chamber to generate hydrogen gas. In addition, a fuel cell system using the fuel cartridge and a power management method thereof are also provided.
US08486577B2 Fuel cell system
In a fuel cell system of the invention, a hydrogen leakage detection process closes a shutoff valve, which shuts off a supply of hydrogen from a hydrogen supply unit into a hydrogen supply flow path, and opens a pressure regulator, which reduces a pressure of hydrogen in the hydrogen supply flow path, so as to keep the hydrogen supply flow path in a state with no pressure regulation and make the fuel cell system in a leakage detectable state. In this leakage detectable state, the hydrogen leakage detection process measures at least one of a pressure and a flow rate as a state quantity of hydrogen in the hydrogen supply flow path that feeds the supply of hydrogen to fuel cells. The hydrogen leakage detection process analyzes a detected behavior of the state quantity in the leakage detectable process and specifies the occurrence of a hydrogen leakage in the downstream of the hydrogen supply unit. This arrangement enables highly accurate detection of a hydrogen leakage in the fuel cell system with the pressure regulator provided in the hydrogen supply flow path.
US08486572B2 System and method of fuel cell power generation
A fuel cell power generation system includes a fuel gas generating means for generating a hydrogen-rich fuel gas from a source material having, as a main ingredient, a compound containing carbon and hydrogen; a source material supply source for supplying a source material to the fuel gas generating means; a fuel gas supply means for supplying the fuel gas from the fuel gas generating means to a fuel gas flow channel of a fuel cell at which channel a fuel electrode is placed; and a bypass means for supplying the source material from the source material supply source to the fuel gas flow channel, bypassing the fuel gas generating means. At least at one of time periods before start of and after end of power generation, the source material, as a displacement gas, is injected into the fuel gas flow channel of the fuel cell via the bypass means.
US08486571B2 Method for controlling output of fuel cell in fuel cell hybrid vehicle
The present invention provides a method for controlling output of a fuel cell to improve fuel efficiency of a fuel cell hybrid vehicle, in which the fuel cell is operated at a constant power at a maximum efficiency point, wherein the fuel cell and a storage means are directly connected if the output and energy of the storage means is insufficient, and the power generation of the fuel cell is stopped when the level of energy of the storage means is increased during stopping or during low power operation such that the fuel cell is intensively operated at the maximum efficiency point, thus improving the fuel efficiency of the fuel cell and the efficiency of the fuel cell system.
US08486570B2 Apparatus for high efficiency operation of fuel cell systems and method of manufacturing same
A drive circuit comprising a DC bus configured to supply power to a load, a first fuel cell coupled to the DC bus and configured to provide a first power output to the DC bus, and a second fuel cell coupled to the DC bus and configured to provide a second power output to the DC bus supplemental to the first fuel cell. The drive circuit further includes an energy storage device coupled to the DC bus and configured to receive energy from the DC bus when a combined output of the first and second fuel cells is greater than a power demand from a load, and provide energy to the DC bus when the combined output of the first and second fuel cells is less than the power demand from the load.
US08486569B2 Lithium/carbon monofluoride batteries with organosilicon electrolytes
Disclosed are lithium/carbon monofluoride batteries suitable for long term use at highly elevated temperatures. Organosilicon electrolytes having low vapor pressure and high flash points are used, along with lithium salts and ceramic separators. Methods of using these batteries at high temperatures are also disclosed.
US08486568B2 Preparation process of all-solid battery
Preparation process of an all-solid battery, comprising forming a linear active material part by relatively moving a first nozzle which discharges active material linearly with respect to a current collector to form a plurality of linear active material parts on the current collector, forming a first electrolyte layer by relatively moving a second nozzle which discharges first electrolyte material with respect to the current collector to apply first electrolyte material to each of the plurality of linear active material parts to form linear electrolyte parts thereon to thereby prepare linear active material-electrolyte parts, photo-curing by irradiating light to the linear electrolyte parts to cure them, and forming a second electrolyte layer by applying second electrolyte material to the whole of the linear active material-electrolyte parts and spaces on the current collector between the linear active material-electrolyte parts to prepare the second electrolyte layer.
US08486559B2 Secondary battery with support member for terminal
A secondary battery includes a bare cell and a protection circuit module electrically connected to the bare cell. The protection circuit module includes a flexible printed circuit board including a circuit board body and a terminal-forming portion providing a first external terminal and a second external terminal and a support member to which the terminal-forming portion is attached, the support member having a support surface spaced from the circuit board body.
US08486557B2 Battery module of improved welding reliability and battery pack employed with the same
Disclosed herein is a battery module including a plurality of sequentially stacked plate-shaped battery cells, wherein the battery module is configured to have a structure in which two or more cell units are stacked in a state in which the battery cells are electrically connected to each other, each of the cell units is configured to have a structure in which two or more battery cells are connected in parallel to each other in a state in which the battery cells are in tight contact with each other, and parallel connection between electrode terminals of the battery cells of the cell units is achieved by one to one welding at a single weld point.
US08486554B2 Alkaline battery separator, process for production thereof and alkaline batteries
An alkaline battery separator comprises a fused fiber layer, and a fine fiber layer adjacent to the fused fiber layer and comprising fine fibers and second fusible fibers, which are fused in the fine fiber layer, wherein part of the fine fibers are incorporated into the fused fiber layer, so that in determining a delamination strength between the fused fiber layer and the fine fiber layer, delamination occurs in the fine fiber layer and therefore the determination results in failure. A process for manufacturing the separator includes preparing a fused fiber sheet, preparing a slurry containing fine fibers and second fusible fibers, scooping up the slurry with the fused fiber sheet, to thereby incorporate part of the fine fibers into the fused fiber sheet, and fusing the second fusible fibers in the fused fiber sheet.
US08486552B2 Battery module having cooling manifold with ported screws and method for cooling the battery module
A battery module having a cooling manifold is provided. The battery module includes a plurality of battery cell assemblies having a plurality of heat exchangers. The battery module further includes a first cooling manifold having a first inlet aperture extending therethrough and a first plurality of outlet apertures extending therethrough. The battery module further includes a first plurality of ported screws disposed through the first plurality of outlet apertures and configured to fluidly and physically couple the plurality of heat exchangers to the first cooling manifold.
US08486548B2 Battery storage system
A battery storage system includes: a plurality of battery modules that are electrically connected in series and in parallel, each comprising a plurality of battery cells; a plurality of sensors provided to each of the plurality of battery modules, that output at least signals corresponding to voltage and current of the each of the battery modules; a plurality of first control devices each of which is provided to the each of the plurality of battery modules, and obtains a power that can be inputted and outputted to and from the each of the battery modules based upon the voltage and current obtained from the output signals of the sensors of the each of the battery modules; and a second control device that performs overall control of the plurality of first control devices, and if a fault of a sensor in any one of the plurality of battery modules has occurred, the second control device obtains a total power that can be inputted and outputted to and from the all of the battery modules, based upon powers each of which can be inputted and outputted to and from each of other battery modules than a battery module in which the sensor has detected the fault, and outputs information of the total power.
US08486542B2 Coated article
An coated article includes a substrate; and a coating deposited on the substrate, wherein the coating being a zirconium layer co-doped with M and R. M is at least one element selected from a group consisting of iron, cobalt, nickel, copper, niobium, hafnium and tantalum. R is at least one element selected from a group consisting of scandium, yttrium and lanthanide.
US08486535B1 Systems and methods for adherable and removable thin flexible glass
A flexible assembly is configured to be removably applied to a curved or planar surface of an underlying component. The assembly includes a flexible glass layer and an adhesive layer provided on at least one surface of the flexible glass layer. The flexible glass layer and the adhesive layer in combination enable the flexible assembly to be removably secured to the curved or planar surface.
US08486533B2 Anti-corrosion conformal coating for metal conductors electrically connecting an electronic component
An apparatus includes an electronic component mounted on a substrate and metal conductors electrically connecting the electronic component. A conformal coating overlies the metal conductors and comprises a polymer into which a phosphine compound is impregnated and/or covalently bonded. Accordingly, the conformal coating is able to protect the metal conductors from corrosion caused by sulfur components (e.g., elemental sulfur, hydrogen sulfide, and/or sulfur oxides) in the air. That is, the phosphine compound in the polymer reacts with any corrosion inducing sulfur component in the air and prevents the sulfur component from reacting with the underlying metal conductors. Preferably, the phosphine compound in the polymer does not react with other components in the air (e.g., carbon dioxide) which would otherwise deplete its availability for the target reaction. The phosphine compound may be rendered completely non-volatile by covalently bonding it directly into the polymer backbone.
US08486531B2 Thermally expanded microspheres and a process for producing the same
The present invention provides heat-expanded microspheres having high packing efficiency, and a production method thereof. The heat-expanded microspheres are produced by expanding heat-expandable microspheres, which comprise shell of thermoplastic resin and a blowing agent encapsulated therein having a boiling point not higher than the softening point of the thermoplastic resin and have an average particle size from 1 to 100 micrometer, at a temperature not lower than their expansion initiating temperature, and the heat-expanded microspheres result in a void fraction not higher than 0.70.
US08486527B2 Compact, hybrid fiber reinforced rods for optical cable reinforcements and method for making same
Fiber reinforcement rods having a combination of reinforcing fiber members coated with a UV curable vinyl ester resin material and a polybutylene terephthalate/polyether glycol or ethylene acrylic acid topcoat layer. The reinforcing fiber members may be S-type fiber members, E-type glass fiber members, a combination thereof, or E-type glass fiber members and/or S-type glass fiber members with high strength synthetic strands of poly (p-phenylene 2,6 benzoisoxazole fiber members. The topcoat layer provides enhanced properties of specific adhesion, enhanced environmental protection, resistance to surface fiber breakage, and to some degree resistance from delamination.
US08486526B2 Low volatiles coatings, sealants and binders from renewable oils
A composition comprises (a) a binder component which comprises (1) 5 to 100 weight percent of at least one natural oil derived polyol having at least about 50 percent primary hydroxyl groups and (2) sufficient additional polyol different from a natural oil derived polyol to make 100 percent wherein the natural oil derived polyol has an average of from 1.5 to 3 hydroxyl groups per molecule and an equivalent weight of from 200 to 5000; and (b) a crosslinking component reactive with hydroxyl groups. Furthermore, a process for producing a coating, adhesive, binder or combination thereof on the surface of a substrate, comprises in any order: (a) admixing binder and crosslinking components of a composition to form an admixture, wherein a binder component comprises (1) 5 to 100 weight percent of at least one natural oil derived polyol having at least about 50 percent primary hydroxyl groups and (2) sufficient additional polyol different from a natural oil derived polyol to make 100 percent wherein the natural oil derived polyol has an average of from 1.5 to 3 hydroxyl groups per molecule and an equivalent weight of from 200 to 5000; and (b) applying a layer of said admixture on said surface. The invention includes coatings, adhesives, binders and combinations thereof prepared from any composition of the invention, substrates coated by the process of the invention or coated using a composition of the invention and articles, including laminates, comprising a coating, adhesive, binder or combination thereof of the invention.
US08486525B2 Method and apparatus having two surfaces for sealing distribution ducts
An application for an arced sealing tape has a bottom interfaced to an inner wall. The surface of the inner wall that is closest to a center point of the arc has an adhesive and the bottom surface of the bottom also has an adhesive.
US08486524B2 Double-sided pressure-sensitive adhesive tape
The present invention relates to a double-sided pressure-sensitive adhesive tape comprising a nonwoven fabric as a support; one pressure-sensitive adhesive layer disposed on one side of the support; and another pressure-sensitive adhesive layer disposed on the other side of the support, wherein the nonwoven fabric consists of Manila hemp and is impregnated with carboxymethyl cellulose. The double-sided pressure-sensitive adhesive tape according to the invention can be produced with a high productivity, does not cause shrinkage wrinkles even when prepared by direct application, and has good blanking workability owing to its small elongation and excellent strength.
US08486520B2 Thermal spray coating of porous nanostructured ceramic feedstock
By engineering thermal spray parameters, such as temperature and velocity, and engineering feedstock powder size and morphology, ceramic coatings may be produced having desired mechanical and thermal properties. The ceramic thermal spray coating may have a microstructure having about 10-80% by cross-sectional area of a particulate phase based on, surface area of the coating, and the particulate phase is uniformly distributed throughout the coating. The particulate phase is an unmelted portion of the thermal sprayed feedstock, which is highly porous and may be produced by agglomerating nanoparticles of the ceramic. Such coatings can be applied as TBCs or as abradable coatings.
US08486518B2 Epoxy resin for prepreg, prepreg, and fiber-reinforced composite material and methods for production thereof
An epoxy resin composition suitably used for a prepreg which can complete curing in a short time even at a low temperature and secure a sufficient usable period under preservation at room temperature, in comparison with conventional epoxy resin compositions. An epoxy resin composition comprising at least one of an epoxy resin, an amine compound having at least one sulfur atom in the molecule thereof, and a reaction product of an epoxy resin and an amine compound having at least one sulfur atom in the molecule thereof, and an amine compound having at least one sulfur atom in the molecule thereof, and a urea compound and a dicyandiamide, wherein each of the contents of the sulfur atom and the urea compound in the epoxy resin composition is respectively 0.2 to 7% by mass and 1 to 15% by mass.
US08486511B2 Pattern formation employing self-assembled material
In one embodiment, Hexagonal tiles encompassing a large are divided into three groups, each containing ⅓ of all hexagonal tiles that are disjoined among one another. Openings for the hexagonal tiles in each group are formed in a template layer, and a set of self-assembling block copolymers is applied and patterned within each opening. This process is repeated three times to encompass all three groups, resulting in a self-aligned pattern extending over a wide area. In another embodiment, the large area is divided into rectangular tiles of two non-overlapping and complementary groups. Each rectangular area has a width less than the range of order of self-assembling block copolymers. Self-assembled self-aligned line and space structures are formed in each group in a sequential manner so that a line and space pattern is formed over a large area extending beyond the range of order.
US08486500B2 Flat bottom bag
A bag and a method of making a bag having a first panel, a second panel and gusseted side panel, and each side panel having a tuck forming, folding geometry with folds intersecting at junctions with longitudinal folds at the first panel and second panel, and having an apex intersecting the center gusset fold, the apex and the junctions being intersected with respective transverse creases, at least a first region of the bag being flattened, a turned back portion of the first panel being turned back on itself and folded along one of the transverse creases, and the first region being pivoted and flattened against the turned back portion of the first panel An end of the bag is covered with a tamper evident structure having an adhesive tape with or without a tamper evidence security device and with or without a tear strip
US08486498B2 Thermally decomposable polymer coated metal powders
The present invention relates to polymer coated metal powders, such as metal powders used in the formation of solder alloys and pastes. The metal powders are coated with curable compositions of cyanoacrylates. The present invention relates to polymer coated metal powders, such as metal powders used in the formation of solder alloys and pastes. The metal powders are coated with curable compositions of cyanoacrylates, and once cured the coating on the metal powder is a cyanoacrylate polymer.
US08486495B2 Siloxane removal via silicate formation for lifetime extension of photocatalytic devices
A method of forming a photocatalyst device includes depositing a layer of UV photocatalyst and depositing islands of a sequestering agent on a surface of the layer of the UV photocatalyst.
US08486494B2 Organic/inorganic composite coating film, structural color film using the same, and preparation methods thereof
An organic/inorganic composite coating film comprising an inorganic material as a matrix and an organic material combined therewith. The coating film has a regular hollow structure therein, and the coating film surface has a rugged pattern with semispherical protrusions. Also provided is a large-area structural color film obtained by burning the composite coating film. The organic/inorganic composite coating film is obtained by applying an aqueous coating composition comprising a metal alkoxide, an aqueous dispersion of monodisperse polymer particles, and an acid catalyst to a substrate and curing the coating composition. Burning the organic/inorganic composite coating film gives the structural color film.
US08486492B2 Complex oxide film and method for producing same, composite body and method for producing same, dielectric material, piezoelectric material, capacitor, piezoelectric element and electronic device
The invention aims at providing a complex oxide film having a high relative dielectric constant and a high voltage resistance, whose film thickness can be arbitrarily controlled, and a manufacturing method thereof, a composite body comprising the complex oxide film and a manufacturing method thereof, a dielectric or piezoelectric material comprising the complex oxide film or composite body, a capacitor or piezoelectric element comprising the complex oxide film advantageous to improve voltage resistance, and an electronic device equipped with the same, without involving any complicated or large scale equipment. The complex oxide film can be obtained by forming a metal oxide film containing a titanium element on a substrate surface and then allowing a solution containing strontium ion to react with the metal oxide film. A capacitor including the complex oxide film as dielectric material and a piezoelectric element including it as piezoelectric material can be produced.
US08486490B2 Method for producing a three-dimensionally shaped object
In a method for producing a three-dimensionally shaped object, a powder layer is formed by feeding a powdery material to a substrate and a solidified layer is formed by irradiating a light beam on a specified portion of the powder layer to sinter or melt the specified portion of the powder layer. A three-dimensionally shaped object having a plurality of solidified layers laminated one above another is obtained by repeating the powder layer formation and the solidified layer formation. In the method, a stress is preliminarily applied to the substrate to reduce the amount of deformation of the substrate after production of the shaped object prior to the powder layer forming step.
US08486489B2 Methods for aligning polymer films and related structures
Methods and a structure. The method includes applying a solution including two or more immiscible polymers to a substructure including features having at least one sidewall and a bottom surface. The immiscible polymers include a first polymer and a second polymer. The at least one sidewall includes a material. A selective chemical affinity of the first polymer for the material is greater than a selective chemical affinity of the second polymer for the material. The first polymer is segregated from the second polymer. The first polymer selectively migrates to the at least one sidewall, resulting in the first polymer being disposed between the at least one sidewall and the second polymer. One or more immiscible polymers is selectively removed. At least one immiscible polymer remains, resulting in forming structures including the substructure and the immiscible polymer remaining. Two additional methods and a structure are also included.
US08486484B2 Implant comprising a biotoxic coating and method for the production thereof
Disclosed is a method for producing an implant coating that has a defined toxicity. The method is characterized by the following steps: i. a sol is produced from a biotoxic solution containing precious metal ions and a precursor solution for a titanium oxide; ii. an implant is coated by applying the sol in a sol-gel process; iii. the coating is pyrolyzed and sintered without admitting any light, the precious metal ion concentration in the dried coating ranging from 10 to 60 percent relative to the total weight of the dried coating; and iv. at least subareas of the coating produced without admitting any light are illuminated in order to reduce the toxicity of the dried coating to a predetermined measure.
US08486483B2 Deposition of discrete nanoparticles on an implant surface
A method of forming a nanocrystalline surface on an implant. The method includes the act of roughening at least a portion of the implant surface to form a roughened surface. The method further includes the act of, without forming an alkoxide on the roughened surface, depositing nanocrystals on the roughened surface. The nanocrystals include a material having a property that promotes osseointegration.
US08486474B2 Compositions and processes for improving carbonatation clarification of sugar liquors and syrups
This invention relates to compositions and processes for improving the carbonatation clarification of sugar liquors and syrups. The improved processes involve adding compositions to a sugar liquor directly in the carbonated liquor holding tank (after the final carbonatation saturator), upstream of the carbonated liquor holding tank but downstream of the final stage Carbonatation saturator, before filtration of the carbonated liquor, or at any stage in the sugar purification process. The compositions provided in this invention are mixed intimately into the sugar liquors or syrups, and allowed sufficient time to react to impart an improvement in the clarified liquor obtained therefrom. Compositions can include combinations of one or more of a particulate sulfur reagent, particulate phosphorous reagent, particulate aluminum reagent, silica reagent, particulate carbonaceous reagent, particulate filter aid, a polymer decolorant, and particulate ammonium reagent.
US08486472B2 Antimicrobial salt solutions for food safety applications
Antimicrobial formulations and solutions for food safety and quality applications are disclosed. Because some of these formulations and solutions contain a substantial concentration of salt, they are adaptable to a variety of food-processing applications, such as for chilling brine applications, disinfecting meat baths/rinses, beef injection brines, poultry chill tanks, brines used in cheese manufacture, as a wash to kill salmonella and other bacteria on hard-boiled eggs or egg shells, and as a wash to disinfect produce, which can become contaminated with salmonella and other pathogenic bacteria in the field. These uses of concentrated salt solutions that depress the freezing point of the solution provide a low temperature bath or shower in which food products can be cooled. One embodiment comprises between 25 ppm and 100,000 ppm surfactant and between 72% and 99.99% salt. This blend can then be dissolved in water to make a solution of between about 1% total solids by weight up to the saturation point, which can be used as an antimicrobial solution for food safety applications.
US08486471B2 Snack/convenience foods and the like having external and/or internal coating compositions
The disclosure describes new forms of chip-type and other fried or baked snack-type and/or convenience food items, including sweet goods such as cookies, doughnuts, etc., which are externally coated with or which directly incorporate into their dough matrix certain starch-based compositions. Methods of using the compositions to make the food products, and the finished food products themselves are described. As external coatings, the compositions significantly increase the crispness and tensile strength of the food item after it is cooked with the coating in place, and so change the organoleptic qualities as to provide a new form of the underlying food product. On sweet goods, the coating also provides a surface barrier that stabilizes sugar icing on the outside of the product, preventing it from becoming tacky, moist, or wet, while simultaneously reducing moisture loss from the dough, adding crispness at the surface and greatly retarding staling.
US08486465B1 Therapeutic nerium oleander extract compositions and methods of using
The compositions and methods described herein relate generally to therapeutic compositions containing Nerium species extracts, as well as to methods for treating diseases or disorders by administering the compositions, including compositions having a combination of Nerium species extract and glutathione. It further includes pharmaceutical compositions containing a combination of glutathione and a Nerium species extract. The compositions and methods disclosed may be useful for treating a variety of diseases or disorders including one or more cell-proliferative diseases or disorders, infections, and dementias.
US08486461B2 Methods for improving the appearance of aging skin using a composition comprising banyan tree, lotus, and clover serum fractions
A method of improving the appearance of aging skin may comprise the step of applying a composition comprising an effective amount of banyan tree serum fraction, lotus serum fraction, and clover serum fraction to a sign of aging on a skin surface, wherein the composition is applied for a period of time sufficient to improve the appearance of the aging skin. The method may include the step of identifying a sign of aging on a facial skin surface.
US08486458B2 Methods and compositions for extracting flavor and fragrance compounds and solubilizing essential oils
Provided are methods for extracting flavor and fragrance materials from natural plant materials, using poly(trimethylene ether) glycol homopolymers and copolymers. The poly(trimethylene ether) glycol homopolymers and copolymers act as solubilizers for essential oils, and can be used to provide compositions having a variety of uses in applications such as cosmetics, personal care products, and industrial cleaning products.
US08486456B2 Itraconazole compositions with improved bioavailability
A solid dispersion product comprising itraconazole and hydroxypropyl methylcellulose, which satisfies the Formula 0.35>ΔHtr (1) (wherein ΔHtr represents the endotherm (J/g) accompanying a transition at about 240° C). The solid dispersion product shows an improved bioavailability.
US08486452B2 Stabilized tolterodine tartrate formulations
A pharmaceutical composition contains tolterodine L-tartrate stabilized against degradation with an acid. Acid-stabilized tolterodine L-tartrate may be used to make various types of immediate release and controlled release dosage forms.
US08486451B2 Adsorption and release of nitric oxide in metal organic frameworks
Disclosed are metal organic frameworks that adsorb nitric oxide, NO-loaded metal organic frameworks, methods of preparing the NO-loaded metal organic frameworks, methods of releasing the nitric oxide into a solution or into air, and uses of the metal organic frameworks.
US08486450B2 Method of producing solid preparation disintegrating in the oral cavity
It is intended to provide a method of producing a solid preparation disintegrating in the oral cavity characterized by comprising mixing fine subtilaes containing a medicinal ingredient with an additive containing δ-mannitol and tableting the mixture; and a solid preparation disintegrating in the oral cavity produced thereby. This solid preparation disintegrating in the oral cavity has such a strength (hardness) as suffering from no defect even under stresses in transporting, packaging with the use of an automated packaging machine, taking out from a PTP and soon.
US08486449B2 Misuse preventative, controlled release formulation
Disclosed is a misuse preventative, controlled release composition in the form of a multilayered oral dosage form. A first layer contains a plurality of controlled release microparticles having a pharmaceutically active agent (for example, an opioid analgesic) disposed therein. The second layer, which can be adjacent the first layer comprises a pharmaceutically active agent that can be the same or different from the pharmaceutically active agent in the microparticles in the first layer. The composition further comprises a superabsorbent material (for example, polycarbophil) disposed within the first layer, the second layer, or both the first layer and the second layer. When intact, the pharmaceutically active agent is released from the second layer faster than the pharmaceutically active agent in the first layer. When crushed, either intentionally or accidentally, and exposed to an aqueous medium, the superabsorbent material present swells to encapsulate the microparticles, which remain substantially intact thereby retarding the release of the pharmaceutically active agent from the composition. Also disclosed is a method of using the misuse preventative, controlled release composition to deliver at least one pharmaceutically active agent to a mammal, for example, a human, in need thereof.
US08486448B2 Misuse preventative, controlled release formulation
Disclosed is a misuse preventative, controlled release formulation comprising a core comprising a superabsorbent material (for example, polycarbophil), a controlled release coat surrounding the core, and a plurality of controlled release microparticles having a pharmaceutically active agent (for example, an opioid analgesic) disposed within the core, the coat, or both the core and the coat. When crushed, either intentionally or accidentally, and exposed to an aqueous medium, the superabsorbent material present in the core swells to encapsulate the microparticles, which remain substantially intact thereby retarding the release of the pharmaceutically active agent from the formulation. Also disclosed is a method of using the misuse preventative, controlled release formulation to deliver a pharmaceutically active agent to a mammal, for example, a human, in need thereof.
US08486447B2 Pharmaceutical formulation
The present invention provides processes for making and forms of solid dispersions of pharmaceutical active ingredients.
US08486440B2 Drug delivery system
Currently, no efficient, non-invasive methods exist for delivering drugs and/or other therapeutic agents to the interior of the eye to treat or prevent disease or injury. The present invention relates to a novel method that is suitable for the delivery of any therapeutic agent (suitably modified) to the interior of the eye without the need for the penetration of a needle into the eyeball. In a preferred embodiment, it involves an injection into a peripheral vein (or oral administration, or administration by some other eternal or parenteral route) of a solution of inert drug which is trapped in the eye by a magnetic field and activated by radiation once it is in position, so that the active agent is released only where it is needed and can have its therapeutic effect without affecting other tissues or organs. The inert drug may be composed of a biologically compatible magnetic nanoparticle chemically bound to a specially inactivated (caged) form of the drug to be delivered and to a luminescent marker.
US08486439B2 Parenteral formulation
The present invention relates to a kinetic implant comprising(a) biodegradable material comprising opened starch, destructurized starch or a mixture of opened starch and destructurized starch, (b) a biologically or pharmaceutically active substance; and (c) a stabilizing component stabilizing the biologically or pharmaceutically active substance. The biodegradable material comprises about 50 to about 100 wt. % of opened starch, destructurized starch or a mixture of opened starch, based on the total weight of the biodegradable material, the biodegradable material having a bulk density of 1.0 to 1.5 kg/dm3. The kinetic implant has a length :diameter ratio of more than 4, provided that the length of the kinetic implant is between 1 mm to 50 mm. The kinetic implant has a weight such that it can be provided with an amount of kinetic energy in the range of 0.1 to 10 J.
US08486435B2 Core-sheath implant device having an inner core lobe
The core-sheath implant device allows for a bioactive agent release profile that can be tailored to a particular therapy. The device features one or more lobes extending from an inner core at least partially through the outer sheath. Depending on the particular design of such an implant device, a variety of release profiles can be achieved.
US08486434B2 Medical implant containing an antioxidative substance
One embodiment of the invention concerns a medical implant having a basic body that includes the antioxidative substance squalene incorporated into at least one of the basic body and a coating on at least a portion of the basic body, the incorporated squalene being present in quantities of 0.4 μg to 2000 μg.
US08486433B2 Antibacterial deodorant
Present invention provides an antibacterial deodorant with antibacterial characteristics and high deodorizing capability. The antibacterial deodorant is inorganic oxide particles comprising a metal component and an inorganic oxide other than the metal component, the inorganic oxide includes titanium oxide and silica and/or zirconia, and the titanium oxide is crystalline titanium oxide. A content of the metal component in the inorganic oxide particles is in a range from 0.1 to 30% by weight as converted to an oxide thereof, and an average particle diameter of the inorganic oxide particle is in a range from 2 to 500 nm.
US08486431B2 Method of controlling floating virus infection
A method of controlling floating virus infection. The method includes the step of: supplying chlorine dioxide gas into a space where floating virus can be present by a gas concentration which allows the animal to live or stay, but deactivates the virus.
US08486418B2 Recombinant avian paramyxovirus vaccine and method for making and using thereof
The present invention encompasses engineered APMV compositions or vaccines. The vaccine or composition may be a recombinant APMV composition or vaccine. The present invention encompasses methods for modifying the genome of APMV to produce recombinant APMV; modified APMV prepared by such methods; DNA and protein sequences; and methods for infecting cells and host animals with such recombinant APMV.
US08486417B2 Recombinant bicistronic Flavivirus vectors
This invention relates to bicistronic flavivirus vectors, methods of using such vectors in the prevention and treatment of disease, and methods of making such vectors.
US08486413B2 Immunological compositions as cancer therapeutics
The present invention concerns antibodies that react immunologically with an epitope comprising VDKSRWQQG (SEQ ID NO: 1), including those that bind to cancer cells, and methods relating thereto. In particular, the antibodies that react immunologically with a particular epitope found in anti-tumor antigen antibodies are not only indicative of favorable therapy using the anti-tumor antigen antibodies, but are therapeutic in and of themselves.
US08486411B2 Methods for identifying an epitope of a polypeptide, chlamydial antigenic polypeptides identified thereby, and methods of use thereof
The present invention provides a method of classifying an epitope displayed by a polypeptide; a method of determining the presence of an epitope on a polypeptide encoded by a test nucleotide sequence; and a method of generating a nucleotide sequence encoding a polypeptide that exhibits a selected epitope. The present invention provides antigenic polypeptides that display selected epitope(s); chimeric macromolecules comprising such polypeptides; and compositions comprising the antigenic polypeptides or chimeric macromolecules. The present invention further provides methods of inducing an immune response to a Chlamydia. The present invention further provides arrays of nucleic acids, arrays of polypeptides, and arrays of antibodies, which arrays are useful in identification and/or classification of a Chlamydia.
US08486407B2 Methods for the treatment or prevention of systemic sclerosis
The invention is in the field of molecular immunology, more in particular in the field of the prevention or treatment of autoimmune diseases, more in particular systemic sclerosis or scleroderma. The invention is based on the observation that SSC patients have an elevated plasma level of CXCL4. This was found to contribute to the pathogenesis of SSc, in particular fibrosis. When CXCL4 was neutralized in in vitro experiments, the fibrotic effects could be neutralized. This led us to conclude that SSc may be cured by reducing the plasma level of CXCL4. The invention therefore relates to a method for treatment or prevention of fibrosis in patients with scleroderma, wherein the plasma level of CXCL4 is reduced.
US08486405B2 Method for diagnosing and treating emphysema
The present invention provides methods for diagnosing a patient with emphysema or COPD by detecting the levels of EMAP II in a sample. Alternatively, methods are provided for determining the susceptibility of a patient to develop emphysema or COPD by detecting the levels of EMAP II in a sample. The levels of EMAP II may be determined by immunoassay techniques. The present invention also provides methods for treating patients with emphysema or COPD by administering a therapeutically effective amount of an EMAP II neutralizing compound. The compound may be an antibody, siRNA, antisense RNA or an antagonist of CXCR3.
US08486404B2 Antibody specifically binding to angiopoietin-2 and use thereof
An antibody specifically binding to angiopoietin-2, and antigen-binding fragments thereof, and a use thereof are disclosed.
US08486402B2 Anti-CD98 antibody
A human antibody or a functional fragment thereof having specific binding ability to CD98 which is derived from the cell membrane of cancer cells and is in the form of a complex with a protein having an amino acid transporter activity (for example, LAT1) is disclosed. This antibody binds to CD98 in the form of a dimer with LAT1 on the surface of cancer cells, specifically attacks cancer cells expressing CD98 via the immune system by ADCC or CDC, and further inhibits amino acid uptake of the cancer cells via LAT1, to suppress growth of the cancer cells. Accordingly, a preventive and therapeutic agent for cancer comprising this antibody or a fragment thereof, which acts on various cancers, is specific to cancer, and causes no side effect, is provided.
US08486400B2 Methods of inhibiting unwanted cell proliferation using an antibody that binds to sonic hedgehog and inhibits hedgehog signaling
The present application is directed to compositions and methods for inhibiting angiogenesis and treating or preventing unwanted cell proliferation, including tumors, by inhibiting the hedgehog pathway, e.g., with an antagonist of the hedgehog pathway such as those disclosed herein.
US08486398B2 Anticoagulant antidotes comprising antibodies that bind dabigatran and/or related compounds
The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.
US08486396B2 Compositions and methods for diagnosing and treating an inflammation
A method of reducing an inflammatory response in a subject is provided. The method comprising providing to a subject in need thereof a therapeutically effective amount of an agent capable of reducing activity and/or expression of a scavenger receptor or of an effector thereof, thereby reducing the inflammatory response in the subject.
US08486394B2 Generation and Profiling of fully human hucal gold-derived therapeutic antibodies specific for human CD38
The present invention provides novel antibodies and functional fragments thereof specific for CD38, and methods of using the same for the treatment of diseases associated with CD38 expression, including hematological malignancies such as multiple myeloma.
US08486393B2 Monoclonal antibodies for CSPG4 for the diagnosis and treatment of basal breast carcinoma
It is disclosed herein that condroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight melanoma associated antigen, is overexpressed on basal breast carcinoma cells (BBC), specifically triple negative basal breast carcinoma cells (TNBC). Methods for detecting basal breast cancer in a subject are disclosed. Methods are also disclosed for inhibiting the growth of a basal breast cancer cell. These methods include contacting the basal breast cancer cell with an effective amount of an antibody that specifically binds CSPG4. Additional treatment methods, and the use of antibody panels, are also described herein.
US08486389B2 Compositions and methods for treating or preventing oxalate-related disease
The present invention comprises methods and compositions for the reduction of oxalate in humans, animals and plants. For example, the invention provides methods and compositions for the delivery of one ore more oxalate-reducing enzymes to the intestinal tracts of persons and animals. The methods and compositions can be used in treating and preventing oxalate-related conditions.
US08486383B2 Method of treating pulmonary disease with interferons
A method of treating a pulmonary disease such as, for instance idiopathic pulmonary fibrosis (IPF), mixed connective tissue disease and asthma, comprising administering an aerosolized interferon such as interferon γ in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) alone or in combination with other therapeutic agents are provided.
US08486379B2 Lip cosmetics
The present invention provides a lip cosmetic that has excellent secondary adhesion resistance effect, good gloss, and excellent stability. The lip cosmetic of the present invention is characterized by comprising the following components (a) to (c): (a) 4.5 to 35 mass % of isostearyl glyceryl ether; (b) 20 to 80 mass % of one or more kinds of methyl phenyl silicones that do not separate when mixed with (a) and decamethylcyclopentasiloxane at 90° C. and separate when mixed with (a) and decamethylcyclopentasiloxane at 25° C.; (c) 4 to 10 mass % of a wax.
US08486378B1 Human fingernail strengthening and conditioning methods and compositions utilizing natural oils
A Natural oils composition for hardening and strengthening fingernails and toenails in which the natural oils contained therein exhibit ability to self polymerize into a solid film in the presence of oxygen. Oils of this invention are diluted with compatible solvents allowing penetration into the nail. Oils of this invention exhibit an Iodine Value greater than 140 grams of iodine absorbed per 100 grams of oil as measured under the prescribed conditions of a standard method described forthwith. Fingernail strengthening and conditioning compositions with antifungal properties are also disclosed.
US08486374B2 Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
A waterless composition suitable for delivery of an active agent to a body surface or cavity includes a vehicle having about 70% to about 99% by weight of a hydrophilic polar solvent, said hydrophilic solvent selected from the group consisting of (i) a mixture of two or more different polyethylene glycols (PEGs), wherein at least one PEG is a high molecular weight PEG having a melting point greater than 25° C.; and (ii) propylene glycol (PG); about 0% to about 10% of at least one surface active agent; about 0% to about 5% of a polymeric agent; about 0% to about 30% of a secondary hydrophilic solvent; and about 0% to about 5% of a silicone oil; and about 3% to about 25% hydrophobic propellant. The composition is otherwise substantially free of a hydrophobic solvent and includes at least one of a surface active agent and a polymeric agent. The vehicle and the propellant are sufficiently miscible that the components may be homogeneously distributed with mild shaking.
US08486373B2 Intramolecularly-quenched near infrared fluorescent probes
An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.
US08486368B2 Hydrocarbon-decomposing porous catalyst body and process for producing the same, process for producing hydrogen-containing mixed reformed gas from hydrocarbons, and fuel cell system
A process for producing the porous catalyst body for decomposing hydrocarbons, the body containing at least magnesium, aluminum and nickel, and has a pore volume of 0.01 to 0.5 cm3/g, an average pore diameter of not more than 300 Å and an average crushing strength of not less than 3 kgf. The process includes molding hydrotalcite containing at least magnesium, aluminum and nickel, and calcining the resulting molded product at a temperature of 700 to 1500° C.
US08486365B2 Process of conversion of hydrogen sulfide into elemental sulfur on solid oxide catalysts
To minimize the inhibitory effect of sulfur on the oxidation of hydrogen sulfide with oxygen in a gas stream on the solid catalysts, first, the elemental sulfur content in the gas stream is reduced to less than 3.0 mg/l, preferably 0.3 mg/l, and second, the temperature in the oxidation reactor is maintained so that the relative vapor pressure of sulfur in it remains less than 0.25, preferably less than 0.1. The removal of sulfur from the gas stream by washing it with water or aqueous solution decreases the ignition temperature of the process to 155-160° C. Because of this the initial concentration of H2S might be elevate up to about 2% for a regular adiabatic reactor and to 10% by volume for a reactor with a heat-redistributing system.
US08486364B2 Production of graphenic carbon particles utilizing methane precursor material
A method is disclosed for making graphenic carbon particles. The method includes introducing a methane precursor material into a thermal zone, heating the methane precursor material in the thermal zone to form the graphenic carbon particles from the methane precursor material, and collecting the graphenic carbon particles. Apparatus for performing such a method, and graphenic particles produced by the method, are also disclosed.
US08486361B2 System and method for generating a carbon dioxide stream
A flue gas stream processing system includes a fuel reactor for combusting a fuel to generate a flue gas stream including water vapor, carbon monoxide and carbon dioxide. The system includes an oxidation catalyst downstream of the fuel reactor, the oxidation catalyst configured to receive the flue gas stream and oxidize the carbon monoxide to form a carbon dioxide rich flue gas stream, and a processing unit to liquefy carbon dioxide in the carbon dioxide rich flue gas stream and generate an exhaust gas.
US08486360B2 GeCl4 and/or SiCl4 recovery process from optical fibers or glassy residues and process for producing SiCl4 from SiO2 rich materials
A method is provided for producing GeCl4 with or without SiCl4 from optical fibers, the method comprises the steps of: reacting comminuted optical fibers including germanium and optionally silicon oxides with a reagent including a solid carbonaceous reducing agent, chlorine and a boron compound to obtain a gaseous product including gaseous GeCl4, gaseous SiCl4, and gaseous BCl3 in accordance with the reactions: 2BCl3(g)+1.5GeO2=1.5GeCl4(g)+B2O3; 2BCl3(g)+1.5SiO2=1.5SiCl4(g)+B2O; B2O3+1.5C+3Cl2=2BCl3(g)+1.5CO2; and then condensing the gaseous GeCl4, BCl3 and optionally SiCl4 into liquid GeCl4, BCl3 and optionally SiCl4. The invention further provides a method for producing SiCl4 (and optionally GeCl4) from glassy residues obtained from optical fiber manufacturing and wasted optical cables. The method includes the steps of: reacting comminuted glassy residues with a reagent including a solid carbonaceous reducing agent, a salt, a boron compound to obtain a gaseous product including SiCl4, BCl3, and optionally GeCl4; and then condensing the gaseous SiCl4, BCl3 (with or without GeCl4) into liquid SiCl4, BCl3 and GeCl4. There is also provided a method for producing SiCl4 from a SiO2 containing material.
US08486356B2 Alkanolamines for CO2 removal from gas streams
A process for the capture of CO2 from gas streams comprising contacting a CO2 containing gas stream with an aqueous alkanolamine solution, wherein the alkanolamine is selected from the group consisting of: 3-piperidinemethanol, Tricine, 3-quinuclidinol, 3-piperidino-1,2-propanediol and their salts.
US08486355B2 Method for leaching cobalt from oxidised cobalt ores
A method for leaching cobalt from a non-lateritic oxidized cobalt ore, the method comprising the method steps of: curing the non-lateritic oxidized cobalt ore to be leached through the application of an aqueous solution of a cobalt reducing agent selected from the group: iron (II) salts, sulfite salts, sulfur dioxide, and combinations thereof; at a pressure of between about atmospheric pressure and about 5 atmospheres, at a temperature between about 5° C. and about 65° C.; wherein the pH of the aqueous solution of the cobalt reducing agent is between about 1.0 and 10.0; and wherein the relative volumes of the aqueous solution of the cobalt reducing agent and the non-lateritic oxidized cobalt ore to be leached are such that the combination of the aqueous solution of the cobalt reducing agent and the non-lateritic oxidized cobalt ore to be leached forms a mixture with a solids content not less than about 100 g/L of aqueous solution; substantially retaining the aqueous solution of the cobalt reducing agent in contact with the non-lateritic oxidized cobalt; and leaching the cured ore at a pressure of between about atmospheric pressure and about 5 atmospheres, at a temperature between about 5° C. and about 65° C., through the application of an ammonium carbonate solution containing free ammonia thereby producing a pregnant leach solution; then passing the pregnant leach solution resulting to a means for cobalt recovery.
US08486351B2 Apparatus for embedding tissue samples
A histology tissue embedding apparatus including a reservoir for an embedding medium and an outlet valve connected to the reservoir through which the embedding medium is dispensable, and including trigger means which control the operation of the outlet valve, the trigger means having a rest position in which the outlet valve is closed, wherein the rest position of the trigger means in relation to the outlet valve is adjustable.
US08486349B2 Microfluidic flow assay for measuring hemostatic phenotypes
A microfluidic-based flow assay and methods of manufacturing the same are provided. Specifically, the microfluidic flow assay includes a micropatterned surface that induces clot formation and an array of microfluidic channels though which blood flows. The micropatterned surface contains two clotting stimuli, one for inducing platelet adhesion and another for inducing the coagulation cascade.
US08486343B2 Apparatus for producing silicon
A structure for mounting a novel reaction tube is capable of following up the thermal expansion of the reaction tube without the need of hanging down the reaction tube in the apparatus for producing silicon. In a reaction unit in a reaction vessel body of the apparatus for producing silicon, there are provided a gas feed pipe for feeding chlorosilanes and hydrogen, a reaction tube for precipitating silicon, a high-frequency coil arranged on the outer circumferential side of the reaction tube to melt the precipitated silicon, a heat insulating material provided between the reaction tube and the high-frequency coil, and an intermediate wall provided at the lower portion of the reaction unit to support the heat insulating material. The reaction tube is supported on the upper surface of the intermediate wall.
US08486337B2 Device for analyzing the coagulation or aggregation behavior of blood
A device is provided for analyzing the coagulation and/or behavior of blood. The blood flows through an opening (9) that is disposed in a porous part (5) while a substance which influences blood aggregation can be delivered to the blood. A preliminary diffuser chamber (3) from which blood flows to the opening (9) is mounted upstream of the opening (9), and/or a secondary diffuser chamber (4) into which blood flows from the opening (9) is mounted downstream of the opening (9). The substance is arranged on the wall of the preliminary diffuser chamber (3) and/or the secondary diffuser chamber (4) in the form of a coating (8).
US08486335B2 In situ heat induced antigen recovery and staining apparatus and method
An automated microscope slide staining system and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments or a pressurizable common chamber for individually and independently processing a plurality of microscope slides. The apparatus preferably features independently movable slide support elements each having an individually operable heating element.
US08486332B1 Methods and apparatuses for the disinfection of devices and other areas
A method and apparatus for the sanitization, detoxification, disinfection, high level disinfection, or sterilization of both the interior and exterior surfaces of an object, including those with lumens and/or channels of various sizes, within a closed space, or closed system of space, in addition to their surrounding atmosphere, and relates particularly, though not exclusively, to the generation of an aerosol including an anti-pathogen/toxin/fungal/sporicidal agent(s) or substance(s) (applied agent), or chemical neutralizing agent(s) or substance(s), by way of one or more ultrasonic nebulizer(s). However the applied agent used in the present invention may also be in the form of any gas, vapor, plasma, aerosol, or other form. The apparatus and method also includes an option to incorporate and utilize a means to wash the object. The present invention includes the application of a positive or negative air/gas pressure to the internal space, lumens, ducts, or channels, of an object.
US08486330B2 Zr-Ti-Ni (Cu) based brazing filler alloy compositions with lower melting point for the brazing of titanium alloys
Disclosed is Zr—Ti—Ni(Cu)-based filler alloy composition having low melting point for brazing titanium and titanium alloys. The Zr—Ti—Ni(Cu)-based alloy composition is expressed as: ZraTibNic (Formula 1) where a, b and c denote atomic % of Zr, Ti and Ni, respectively; 47≦a≦52; 24≦b≦30; 22≦c≦26; and 0.3
US08486327B2 Sealing plug for tiltable converters
A sealing plug 1, consisting of fireproof material 10 located between the upper shaping plate 19 and the lower shaping plate 20, is used to seal the tap hole 3 of a tiltable converter 2. Said fireproof material 10 consists of bonding clay, water, oil and other constituents, particularly of 10-30% by weight hollow glass balls made of “foam glass” produced from recovered glass which have a rough surface suitable for binding large volumes of moisture. The sealing plug 1 thus retains the necessary stability even over longer periods and can thus be shaped in the tap hole 3 so that it is arrested against the wall 28, even after longer periods of storage. The hollow glass balls 11, 12, 13, 14 also entail a significant reduction in the weight of the entire sealing plug 1.
US08486325B2 Parison and method for the production of plastic bottles
A parison is described, as also is a method for the production of plastics bottles, in particular PET bottles, this having a rigid, substantially elongate body (2), which has a base (5) at one of its ends. At its opposite end, the body (2) of the parison (1) adjoins a neck section (3) which has been provided with a pouring aperture (6) and which is separated from the body (2) via a radially protruding, flange-like support ring (4), and which has a parison shoulder (A) below the support ring (4). The parison (1) has an external diameter of from 17.4 mm to 21.4 mm measured at the transition of the body (2) to the base (5), its wall thickness at that point being from 3.4 mm to 4.4 mm. The parison (1) also has a wall thickness of from 1.4 mm to 2.2 mm at the parison shoulder (A). The external diameter of the parison shoulder (A) has been judged in such a way that its separation (d) from the blow molding wall (12) is from 1.2 mm to 3 mm when the parison (1) is inserted into the blow mold (10).
US08486321B2 Print through reduction in long fiber reinforced composites by addition of carbon nanotubes
Polymer articles are often reinforced by addition of fibers which may be assembled into a structured reinforcement such as a woven mat or sheet and the mat or sheet serves as the reinforcement. Such woven fiber-reinforced polymer composite articles may exhibit undesirable variations in surface height which mimic the geometry of the underlying reinforcements, a phenomenon known as print through. By forming, on the surface of the article, a relatively thin, layer of a compatible polymer incorporating closely-spaced, short, carbon nanotubes more or less uniformly dispersed throughout the layer and oriented normal to the article surface, print through may be reduced or eliminated. Methods for fabricating such an article are detailed.
US08486314B1 Method of internally restoring a leaking pipe
A method of internally restoring a pipe preferably includes the steps of isolating a leaking pipe from a system of pipes; drying an interior of a leaking pipe; measuring the airflow through the leak; cleaning the interior of the leaking pipe; pre-sealing a leak with a leak sealing media, measuring the leak flow rate after the pre-sealing; applying an internal protective coating process; and pressure testing the leaking pipe for leaks. The pipe restoration method preferably uses a control box, a media injection system, an air compressor and a coating dispensing system at an inlet of the leaking pipe. The pipe restoration method preferably uses a coating overflow receiver, a muffler and a dust collector at an exit of the leaking pipe. After the treatments, the leaking pipe becomes a restored pipe. The restored pipe is pressure tested for leaks at a working pressure rating of the pipe and reconnected to its piping system.
US08486313B2 Flame retarding thermoplastic alloy and its preparation method
The present invention discloses a thermoplastic flame-retardant alloy and a method for preparing it, composed of the following components as below (parts by weight): 5-94 parts of ABS resin, 3-94 parts of polyester or co-polyester or the mixture of both, 1-50 parts of brominated flame retardant, 1-10 parts of flame-retardant aid, 0.001-30 parts of chlorinated polyethylene (CPE), 0.001-2 parts of anti-dripping agent and 0.1-6 parts of processing aid. Comparing with the ABS flame retardant presenting the prior art, the thermoplastic flame-retardant alloy features better glossiness, scratch resistance, stronger ultraviolet radiation resistance and better mechanical property, thus making up for the disadvantage that the flame-retardant ABS is prone to become yellow on some occasions with high weatherability requirements. Furthermore, the preparation method of the thermoplastic flame-retardant alloy for the present invention is successive, stable and feasible.
US08486311B1 Eyewear including catechol functionalized boron pyrromethene dye for neutralizing laser threat
The embodiments described herein generally relate to compositions and articles including dye compounds having desirable optical properties, and related methods. In some cases, the compositions and articles may possess advantageous optical properties, including various degrees of absorbance, emission, and/or transmission at particular wavelengths or ranges of wavelength. Embodiments described herein may be useful as optical filters in protective eyewear applications.
US08486306B2 Nickel ink and conductor film formed of nickel ink
A nickel ink having nickel particles dispersed in a dispersion medium is disclosed. The dispersion medium comprises one member or a combination of two or more members selected from the group consisting of an alcohol and a glycol both having a boiling point of 300° C. or lower at atmospheric pressure. The nickel particles have an average primary particle size of 50 nm or smaller. The nickel ink provides a conductor film with a surface smoothness having an average surface roughness Ra of 10 nm or smaller and a maximum surface roughness Rmax of 200 nm or smaller.
US08486304B2 Gelable composition
A composition including a polymer and a liquid, wherein the polymer exhibits lower solubility in the liquid at room temperature but exhibits greater solubility in the liquid at an elevated temperature, wherein the composition gels when the elevated temperature is lowered to a first lower temperature without agitation, wherein the viscosity of the composition results from a process comprising (a) dissolving at the elevated temperature at least a portion of the polymer in the liquid; (b) lowering the temperature of the composition from the elevated temperature to the first lower temperature; and (c) agitating the composition to disrupt any gelling, wherein the agitating commences at any time prior to, simultaneous with, or subsequent to the lowering the elevated temperature of the composition to the first lower temperature, wherein the amount of the polymer dissolved in the liquid at the elevated temperature ranges from about 0.2% to about 5% based on the total weight of the polymer and the liquid.
US08486290B2 Etching apparatus, analysis apparatus, etching treatment method, and etching treatment program
There is provided an etching apparatus in which, without setting the information of the substance and the chemical reaction, a small number of representative wavelengths can be selected from a waveform at a lot of wavelengths, and an analysis process of etching data which needs large man-hours can be eliminated to efficiently set the monitoring of the etching. The etching apparatus includes: a lot/wafer/step-depending OES-data searching/acquiring function 511 for acquiring a plurality of optical emission intensity waveforms along an etching-treatment time axis; a waveform-change-existence judgment function 521 for judging the existence of the change of the plurality of light emission intensity waveforms; a waveform-correlation-matrix calculating function 522 for calculating a correlation matrix between the optical emission intensity waveforms; a waveform classifying function 523 for classifying the optical emission intensity waveforms into groups; and a representative-waveform selecting function 524 for selecting a representative optical emission intensity waveform from the group.
US08486289B2 System, method and apparatus for fabricating a C-aperture or E-antenna plasmonic near field source for thermal assisted recording applications
A method of fabricating a c-aperture or E-antenna plasmonic near field source for thermal assisted recording applications in hard disk drives is disclosed. A c-aperture or E-antenna is built for recording head applications. The technique employs e-beam lithography, partial reactive ion etching and metal refill to build the c-apertures. This process strategy has the advantage over other techniques in the self-alignment of the c-aperture notch to the c-aperture internal diameter, the small number of process steps required, and the precise and consistent shape of the c-aperture notch itself.
US08486272B2 Method and device for maintaining a constant pH value of a medical liquid during the dispensing thereof from a container
A method for keeping constant a pH of a medical liquid being drained from a container includes adding CO2 and at least one other gas or gas mixture to the container during the draining of the medical liquid. An apparatus associated with the method has an outflow for the medical liquid, at least one inflow for the CO2 and an inflow for the other gas or gas mixture, and an electronic control for the determination and automatic supply of a quantity of the CO2 during the draining of the medical liquid.
US08486270B2 Method of increasing the efficiency in an ore separation process by means of hydrophobic magnetic particles by targeted input of mechanical energy
The present invention relates to a process for separating at least one first material from a mixture comprising this at least one first material and at least one second material, which comprises the following steps (A) contacting of the mixture comprising at least one first material and at least one second material with at least one magnetic particle in the presence of at least one dispersion medium so that the at least one first material and the at least one magnetic particle agglomerate, (B) if appropriate, addition of further dispersion medium to the dispersion obtained in step (A), (C) separation of the agglomerate from step (A) or (B) from the mixture by application of a magnetic field, (D) and dissociation of the agglomerate separated off in step (C) in order to obtain the at least one first material and the at least one magnetic particle separately, with an energy input of at least 10 kW/m3 being introduced into the dispersion in step (A).
US08486268B2 Precision peak matching in liquid chromatography-mass spectroscopy
A method that identifies common peaks among unidentified peaks in the data from different LC-MS or LC-MS/MS runs is provided. The method employs an algorithm, herein referred to as “Precision Peak Matching (PPM).” The different runs can be from different laboratories, instruments, and biological samples that result in a significant variability in the data. PPM allows estimation and control of precision, defined as the fraction of truly identical peptide pairs among all pairs retrieved, in the matching process. PPM finds the maximal number of peptide pairs at a prescribed precision, thereby allowing quantitative control over the trade off between the number of true pairs missed, and false pairs found. PPM finds common peptides from a database of LC-MS runs of heterogeneous origins, and at the specified precision. PPM fills a much-needed role in proteomics by extracting useful information from disparate LC-MS databases in a statistically rigorous and interpretable manner.
US08486267B2 Non-dispersive process for insoluble oil recovery from aqueous slurries
The development and application of a novel non-polar oil recovery process utilizing a non-dispersive solvent extraction method to coalesce and recover oil from a bio-cellular aqueous slurry is described herein. The process could apply to recovery of algal oil from a lysed algae slurry, recovery of Omega fatty acids from a bio-cellular aqueous feed, recovery of Beta-carotene from a bio-cellular aqueous feed and for the removal from produced water in oil production and similar type applications. The technique of the present invention utilizes a microporous hollow fiber (MHF) membrane contactor. The novel non-polar oil recovery process described herein can be coupled to a collecting fluid (a non-polar solvent such as heptane, a biodiesel mixture or the previously extracted oil) that is circulated through the hollow fiber membrane. In cases where the biodiesel mixture or the previously extracted oil is used the solvent recovery step (e.g. distillation) can be eliminated.
US08486260B2 Adjustable drain
A drain assembly includes a receptacle body with a first end and a second end defining a cavity therebetween, an adjustable collar and a grate. The first end of the receptacle body forms an opening into the cavity and comprises a peripheral step with a connection flange extending substantially perpendicularly therefrom, and a peripheral flange with a substantially horizontal support portion extending away from the connection flange. The connection flange includes a series of vertical slots for accommodating horizontally-oriented fastening members, and the connection flange and the peripheral flange define a channel therebetween. The adjustable collar comprises a first flange positioned adjacent to the connection flange of the peripheral step, and a second flange extending substantially perpendicular from the first flange. The first flange includes a series of holes which align with the series of vertical slots in the connection flange. The grate is positioned over the opening of the receptacle body.
US08486259B2 Bulk hydroprocessing catalyst comprising a group VIII metal and molybdenum, preparation and use thereof
The invention relates to a bulk catalyst comprising at least 60 wt % metal oxidic particles comprising one or more Group VIII metals and Group VIB metal molybdenum, comprising less than 10 mole % of a second Group VIB metal (relative to the total amount of Group VIB metals) and comprising a Group V metal in an amount less than 10 mole % (relative to the total of the Group VIB metals), which bulk catalyst has been calcined at a temperature below a temperature where the hexagonal metastable crystal structure changes to an inactive crystalline structure, preferably below 450° C. and which bulk catalyst has a metastable hexagonal phase characterized by an X-ray diffraction pattern having reflections at 33-35 and 58-61° 2θ. Preferably, the main reflections have a full width at half maximum (FWHM) of less than 2.5. The invention further relates to a process for the manufacture of the bulk catalyst, to the corresponding sulphided bulk catalyst and to the use of said catalyst or sulphided catalyst in the hydroprocessing, in particular the hydrodesulphurisation and hydrodenitrogenation, of a hydrocarbon feedstock.
US08486257B2 Blood glucose sensing
An oxidative peak in a cathodic scan is observed in the cyclic voltammetry of glucose at gold electrodes, its peak current density being proportional to glucose concentration in a wide potential range. The application of this phenomenon in blood glucose sensing has been hindered by the presence of inhibitors: the most problematic are chlorides due to their high concentration and difficult separation from glucose. The present invention provides a solution to this problem involving a three electrode, four step pulsed electrochemical detection technique.
US08486252B2 Copper chloride/copper bromide disinfector for swimming pools and control method thereof
A two-in-one copper chloride/copper bromide disinfector and a method of controlling the same. In operation, when copper is released, the positive and negative electrodes of a copper billet are periodically reversed, while the positive and negative electrodes of a titanium plate/graphite polar plate are in an uncharged state. When chlorine/bromine is released, the positive and negative electrodes of a titanium plate/graphite polar plate are periodically reversed, while the positive and negative electrodes of the copper billet are short-connected, then connected to the negative electrode of the titanium plate/graphite polar plate, or applied thereon with an electric voltage that is lower than the electric voltage of the negative electrode of the titanium plate/graphite polar plate. With this method, the copper billet out of operation is shorted-connected to the negative electrode of the titanium plate/graphite polar plate or connected to an electric voltage that is lower than that of the negative electrode. Thus the release amount of copper ions is controllable, the volume of the disinfector is reduced, and the corrosion between the positive and negative electrodes of the copper billet is uniform.
US08486246B2 Reference electrode coated with ionic liquid and electrochemical measurement system using the reference electrode
This invention provides a reference electrode that can be downsized and stable in voltage. The reference electrode in accordance with this invention is a reference electrode that does not require an internal aqueous solution such as a KCl aqueous solution and comprises a metal body, a slightly soluble salt film that comprises a slightly soluble salt of the metal body and that coats the metal body and a hydrophobic ionic liquid that is arranged to make contact with both the slightly soluble salt film and a sample to be measured.
US08486241B2 Sputtering apparatus having gas supply system
An exemplary gas supply system, includes a plurality of first input lines for supplying gas, a plurality of second input lines, a plurality of third input lines, a first mixing tank communicating with the second input lines, a second mixing tank communicating with the third input lines, and a plurality of three-way valves. Each three-way valve is communicated with a first input line, a second input line and a third input line such that gas in the first input lines can be selectively introduced into the first mixing tank or the second mixing tank.
US08486239B2 Electrolysis anode
Methods systems and devices for impeding an anode from being corroded or dissolved are provided. In one example, an electrolysis system includes an anode, the anode disposed on a support including a housing, the housing having an inverted cup on an end, the anode on an interior wall of the inverted cup such that electrical contact with an electrolysis solution is made along a concave portion of the inverted cup. Such an example may further include a cathode, the cathode disposed within a collection pipe such that gas produced at the cathode is retained within a channel of the collection pipe.
US08486238B2 Surface renewable iridium oxide-glass or ceramic composite hydrogen ion electrode
Disclosed herein is a surface renewable iridium oxide-glass or ceramic composite hydrogen ion electrode and, more particularly, a surface renewable iridium oxide-glass or ceramic composite hydrogen ion electrode, which has a long life due to its excellent physical strength, pH dependency approximate to a theoretical value (59 mV/pH unit), and high surface renewability, and a method of manufacturing the same. The iridium oxide composite hydrogen ion electrode according to the present invention is effective in that, when the electrode is contaminated or inactivated, the surface of the electrode can be regenerated through a simple grinding process because the electrode has high surface renewability, unlike conventional electrodes. The iridium oxide composite electrode according to the present invention can be usefully used in a water-quality monitoring system for monitoring the hydrogen ion concentration of a solution for a long period, an online pH measurement system, and pH measurement for samples, which causes serious contamination of the surface of a sensor.
US08486237B2 Process for continuous coating deposition and an apparatus for carrying out the process
An apparatus for continuously forming thin ceramic coatings on metal sheets, foils or wires. The apparatus has a reaction chamber, perforated nylon sheets, nylon bar guides, copper rods attached to a power supply, nylon collecting rods, and an inlet and an outlet. The reaction chamber is capable of containing an electrolytic solution. The copper rods are separately connected to the R, Y, or B phase of the power supply. Each phase is provided with two thyristors and the output of the thyristors is connected to the copper rods using current transformers. A process for continuously forming thin ceramic coatings on metal sheets, foils or wires is also provided.
US08486236B1 Electrolysis chamber
A electrolysis chamber. The electrolysis chamber has first initial product sub-chambers, second initial product sub-chambers, at least one positive electrode, at least one negative electrode, and electrolysis membranes. The first initial product sub-chambers and second initial product sub-chambers communicate with respective manifolds, which in turn communicates with an exterior of the electrolysis chamber through respective ports. Flow control valves set the flow into the first initial product sub-chambers. First, second and third end product manifolds communicate with an exterior of the electrolysis chamber through respective ports. The ports and manifold configuration provides for simple and easy connection and installation of the electrolysis chamber.
US08486233B2 Apparatus, process and system for delivering fluid to a distillation column or reactor
A fluid delivery apparatus is provided for supplying a fluid mixture to a distillation column or reactor. The apparatus can be used to enhance the heat duty, the flow and/or the flow stability of an existing thermosiphon reboiler which supplies a heated fluid to the column or reactor. The apparatus includes an integrated eductor which receives and increases the fluid velocity of a supplemental fluid into which the heated fluid is aspirated to form a fluid mixture then delivered to the column or reactor. A process and a system utilizing the apparatus are also disclosed, as well as a method of retrofitting an existing system with the apparatus.
US08486230B2 Shoe press belt
A belt (shoe press belt) for papermaking machines having good wet paper web water squeezing capability, and wherein damage, cracks, and abrasion of the outer circumferential belt surface during use is small, and due to the reduced abrasion between the cutting chips, the cutter and the groove walls, the cutter life is long and the surface roughness is small. The cross-section in the cross-machine direction of the water draining grooves is provided in the machine direction in the felt-side surface of the shoe press belt and the groove corner parts formed by the groove sidewalls and the groove bottom part of the water draining grooves are chamfered in the shape of a trapezoid or a rectangle.
US08486228B2 Lignocellulosic biomass saccharification pre-treatment device
Provided is a lignocellulosic biomass saccharification pre-treatment device capable of producing a pretreated material for saccharification. The lignocellulosic biomass saccharification pre-treatment device comprises a separation unit 4 which separates ammonia gas by heating a pretreated material for saccharification obtained from a substrate mixture obtained by mixing lignocellulosic biomass and ammonia water; a first heat recovery unit 25 which recovers heat-of-dissolution generated when ammonia gas is dissolved in water, and the heat supply units 8, 9, 10 which generate heat by using heat-of-dissolution recovered by the frst heat recovery unit 25 and supply the heat to the separation unit 4.
US08486227B2 Method for producing paper, paperboard and cardboard
A process for the production of paper, board and cardboard by draining a paper stock containing interfering substances in the presence of polymers which contain vinylamine units and which have an average molar mass Mw of at least 1 million, a high-consistency stock first being prepared, at least one polymer containing vinylamine units and having an average molar mass Mw of at least 1 million and a degree of hydrolysis of from 1 to 20 mol % being metered into the high-consistency stock, the high-consistency stock being diluted to a low-consistency stock by adding water, and the low-consistency stock being drained, the polymers being hydrolyzed homo- or copolymers of N-vinylcarboxamides additives for reducing deposits in the wire part, press section and drying section of paper machines.
US08486224B2 Method for separating lignin from black liquor
Method for separating lignin from black liquor includes the following steps: a) precipitating lignin by acidifying black liquor and thereupon dewatering, b) suspending the lignin filter cake obtained in step a) to obtain a second lignin suspension and adjusting the pH level to approximately that of the washing water of step d) below, c) dewatering of the second lignin suspension, d) adding washing water and performing a displacement washing at substantially constant conditions without any dramatic gradients in the pH, and e) dewatering the lignin cake produced in step d) into a high dryness and displacing the remaining washing liquid in the filter cake, whereby a lignin product is obtained which has an even higher dryness after the displacement washing of step d). The lignin product or an intermediate lignin product obtained by the method, and its use, preferably for the production of heat or chemicals is also disclosed.
US08486223B2 Falling film evaporator
A falling film evaporator having a shell pass, multiple tubes parallel to each other, a condensed steam outlet, an inlet for an aqueous solution on the top of the tube pass, an outlet for the aqueous solution at the bottom of the tube pass, a distributing assembly having a plurality of distributing trays arranged vertically from top to bottom in incremental diameters and each having multiple holes, and a plate for collecting the aqueous solution below the distributing assembly. The tubes are straight and installed vertically in the evaporator; inner wall of the tubes is smooth, and the top portion of the tubes is protruded above a horizontal plane of the plate. The evaporator is particularly useful for concentrating an aqueous solution containing thermosensitive materials.
US08486222B2 Substrate processing apparatus and method of manufacturing a semiconductor device
A substrate processing apparatus includes a processing chamber configured to process a substrate, a substrate support member provided within the processing chamber to support the substrate, a microwave generator provided outside the processing chamber, a waveguide launch port configured to supply a microwave generated by the microwave generator into the processing chamber, wherein the central position of the waveguide launch port is deviated from the central position of the substrate supported on the substrate support member and the waveguide launch port faces a portion of a front surface of the substrate supported on the substrate support member, and a control unit configured to change a relative position of the substrate support member in a horizontal direction with respect to the waveguide launch port.
US08486220B2 Method of assembly of retaining ring for CMP
A carrier head for a chemical mechanical polishing apparatus includes a retaining ring having a flexible lower portion and a rigid upper portion.
US08486217B2 Process for the production of packaging material for electronic component cases
A method of producing a packaging material including a temporary bonding which temporarily bonds a first sheet including a thermoplastic resin non-oriented film layer and a thermoplastic adhesive resin layer laminated on one surface of the thermoplastic resin non-oriented film layer and a second sheet including a heat resistant resin oriented film layer and an aluminum foil layer laminated on one surface of the heat resistant resin oriented film layer by passing the first and second sheets between a pair of rolls in a state in which the thermoplastic adhesive resin layer and the aluminum foil layer are brought into contact with each other to press them while heating in a state in which the thermoplastic adhesive resin does not melt to obtain a pre-laminated sheet, and a complete bonding which integrally bonds the first and second sheets by heating the pre-laminated sheet to melt the thermoplastic adhesive resin.
US08486202B2 Dishwasher
A dishwasher includes a washing compartment having a base wall with a retaining element, and a mains current connection element mounted on the retaining element with which a mains cable can be electrically contacted to the dishwasher.
US08486201B2 Method for drying a semiconductor wafer
Disclosed is a method for drying a plate-like article; the method including rinsing with an aqueous rinsing liquid with subsequent rinsing with an organic solvent, wherein the organic solvent has a water content of below 20 mass-% wherein the organic solvent is supplied at a solvent temperature, which is at least 30° C. and not higher than 60° C.
US08486200B2 Ware washing system containing cationic starch
The present invention discloses a method of washing ware, in particular in an automatic domestic or institutional ware washing machine, using a detergent composition containing a cationic starch. This eliminates the need for a surfactant in the rinse step. The cationic starch provides a layer of cationic starch on the ware so as to afford a sheeting action in an aqueous rinse step without any added rinse agent.
US08486195B2 Atomic layer deposition apparatus and method of fabricating atomic layer using the same
An atomic layer deposition apparatus includes a chamber, a vacuum pump to control a pressure in the chamber, a gas supply unit to supply a reaction gas into the chamber, a substrate holder disposed between the vacuum pump and the gas supply unit and having a heater, a mask assembly disposed between the substrate holder and the gas supply unit and having a cooling path to move coolant, and a coolant source to supply the coolant into the cooling path. The mask assembly is positioned a first distance from a substrate, and coolant is supplied into the cooling path of the mask assembly. The substrate is heated using the heater of the substrate holder, a pressure of the chamber is controlled using the vacuum pump, and reaction gasses are sequentially supplied through the gas supply unit.
US08486194B2 Apparatus for efficient removal of halogen residues from etched substrates
An apparatus for removing volatile residues from a substrate is provided. In one embodiment, an apparatus for removing halogen-containing residues from a substrate includes a chamber suitable for operating maintaining a vacuum therein and a heat module positioned to heat a substrate disposed in the chamber. The apparatus for removing halogen-containing residues from a substrate also includes at least one of A) a temperature controlled pedestal having a projection extending radially therefrom suitable for supporting the temperature control pedestal on a ledge of the chamber body, the projection thermally isolating the base from the chamber body; B) a pair of substrate holders that include two support flanges extending radially inward from an inner edge of an arc-shaped body, each support flange having a substrate support step that includes a sloped landing; or C) a domed window.
US08486190B2 Process for producing single crystal
A raw material mixture containing an easily oxidizable material is weighed. The raw material mixture is melted and then solidified within a reaction vessel 1 set in a non-oxidizing atmosphere to thereby produce a solidified matter 19. The reaction vessel 1 and the solidified matter 19 are heated in a non-oxidizing atmosphere within a crystal growth apparatus to melt the solidified matter to thereby produce a solution. A single crystal is grown from the solution.
US08486188B2 Polyhydroxyfunctional polysiloxane as anti-adhesive and dirt-repellant additives
The invention relates to a method for production of polyhydroxyfunctional polysiloxanes with branched polyglycidol polyether groups, in which firstly at least one allylic or methallylic starting material is reacted with at least one glycidol, such that an allyl polyether or methallyl polyether is formed, and then the allyl polyether or methallyl polyether thus produced is added to a Si—H functional alkyl polysiloxane in the presence of an acid buffering agent. The invention further relates to polysiloxanes, which may be obtained by said method and the use of the polysiloxanes in coating agents, polymeric coating masses and thermoplastics.
US08486187B2 Multipurpose additive for low VOC solvent based coatings
The invention relates to a coating composition comprising at least one binder and a multipurpose additive obtainable by reacting a vegetable oil with a diol or by transesterifying a vegetable oil lower alkyl ester with a diol, both reactions in the presence of a catalyst. The multipurpose additive is used to replace partly the solvent of the coating composition and/or to replace partly the binder thus reducing the VOC content and the viscosity.
US08486186B2 Magenta ink composition, ink cartridge, and recording system and recorded matter using the same
This invention provides a magenta ink composition that, when recorded, is excellent in color development, graininess, and gloss, is less likely to cause clogging in an ink jet recording head, and is excellent in color reproduction in a high-chroma and high-lightness red region. The magenta ink composition has an L* value of not less than 60 and a b* value of not more than −17 when the a* value in CIE standard calculated from a visible absorption spectrum in a not more than 10000-fold diluted aqueous solution is 80.
US08486184B2 Oxygen-permeable membrane and method for the production thereof
A composite membrane for selective gas separation, comprises a layer system having a continuously porous, mechanically stable carrier layer, which has an average pore size in the μm range, further having at least one continuously porous intermediate layer, which is disposed on the carrier layer and has an average pore size in the range of 2 to 200 nm, and further having a gastight functional layer, which is disposed on the intermediate layer and is made of a mixed-conductive material having a maximum layer thickness of 1 μm. The carrier layer comprises a structural ceramic, a metal, or a cermet and has a layer thickness of no more than 1 mm. The intermediate layer is present with a total layer thickness of no more than 100 μm and has an average pore size in the range of 10 to 100 nm. The functional layer comprises a perovskite, a fluorite, or a material having a K2NiF4 structure, such as La1-xSrxCo1-yFeyO3-8 (LSCF). The layer thickness of the functional layer is no more than 50 nm, and particularly between 25 and 400 nm. In order to produce this composite membrane, at least one porous intermediate layer is applied onto a continuously porous, mechanically stable carrier layer, which has an average pore size in the μm range, wherein the intermediate layer has an average pore size in the range of 2 to 200 nm. A further gastight, functional layer made of a mixed-conductive material and having a maximum layer thickness of 1 μm is applied onto the intermediate layer.
US08486180B2 Process for the recovery of a concentrated carbon dioxide stream
A concentrated carbon dioxide stream is produced during a hydrogen pressure swing adsorption unit cycle by fractionating the carbon dioxide removed from the adsorbent in the adsorption beds during the regeneration of the adsorption beds. Thereby providing a cost efficient process for producing merchant carbon dioxide.
US08486179B2 Method for producing carbon molecular sieve membranes in controlled atmospheres
The invention concerns carbon molecular sieve membranes (“CMS membranes”), and more particularly the use of such membranes in gas separation. In particular, the present disclosure concerns an advantageous method for producing CMS membranes with desired selectivity and permeability properties. By controlling and selecting the oxygen concentration in the pyrolysis atmosphere used to produce CMS membranes, membrane selectivity and permeability can be adjusted. Additionally, oxygen concentration can be used in conjunction with pyrolysis temperature to further produce tuned or optimized CMS membranes.
US08486177B2 Heap leaching
A method of leaching a metal value from a heap of a metal-containing ore and a heap leaching operation are disclosed. The method includes establishing a downward flow of a leach liquor through a section of the heap by supplying the leach liquor onto a top surface of the section and allowing the leach liquor (containing metal values in solution) to drain from a lower part of the section. The method is characterized by supplying the leach liquor onto the top surface of the section at a flow rate that is sufficient so that the downwardly flowing leach liquor saturates the section of the heap.
US08486175B2 Grain refiners for steel-manufacturing methods and use
The present invention concerns a new type of grain refiners for steel, in the form of a particulate composite material, containing a high volume fraction of tailor-made dispersed particles, with the purpose of acting as potent heterogeneous nucleation sites for iron crystals during solidification and subsequent thermo-mechanical treatment of the steel. The material comprises a composition of particles of XaSb or XaOb and the element(s) X, where X is one or more elements selected from the group Ce, La, Pr, Nd, Y, Ti, Al, Zr, Ca, Ba, Sr, Mg, Si, Mn, Cr, V, B, Nb, Mo and Fe, and S is sulphur, (O is oxygen), wherein said material additionally contains oxygen, sulphur, carbon and nitrogen, wherein the sulphur (or oxygen) content is between 2 and 30% by weight of said material, while the total content of oxygen (or sulphur), carbon and nitrogen and said other elements selected from the group X is between 98 and 70% by weight of said material, and the said material contains a high volume fraction of finely dispersed XaSb or XaOb particles embedded in a metallic matrix X. The invention further concerns methods for production and use of the composite material.
US08486170B2 Filter apparatus
A filter apparatus comprises first and second filters, each having an upstream surface and a downstream surface. At least one bypass channel extends from a position upstream of the upstream surface of the first filter to a position upstream of the upstream surface of the second filter.
US08486169B2 Method of polishing a silicon-containing dielectric
A chemical-mechanical polishing system comprising: (a) ceria abrasive having an average particle size of about 180 nm or less and a positive zeta potential, (b) a polishing additive bearing a functional group with a pKa of about 3 to about 9, wherein the polishing additive is selected from the group consisting of arylamines, aminoalcohols, aliphatic amines, heterocyclic amines, hydroxamic acids, aminocarboxylic acids, cyclic monocarboxylic acids, unsaturated monocarboxylic acids, substituted phenols, sulfonamides, thiols, salts thereof, and combinations thereof, and (c) a liquid carrier, wherein the chemical-mechanical polishing system has a pH of about 4 to about 6.
US08486168B2 Gasification
A method for the gasification of solid fuel to produce combustible effluent, comprising the steps of: partially oxidizing a biomass fuel in a first oxidation zone to produce char; reducing the char in a reduction zone to form ash; further oxidizing any char residue ash in a second oxidation zone; and extracting the combustible effluent produced in the above steps, by a discharge pipe wherein in the first oxidation zone the gas flow is in the same direction as fuel flow and in the second oxidation zone the gas flow is in the opposite direction to the fuel flow.
US08486167B2 Reformed gas production method and reformed gas production apparatus
The invention provides a method for operating a reformed gas production apparatus with which it is possible to achieve a high reforming efficiency while preventing a drop in catalyst activity due to the deposition of carbon. The reformed gas production method uses a reforming catalyst to reform a fuel that contains a hydrocarbon having at least two carbon atoms to produce a reformed gas that includes methane, hydrogen, and carbon monoxide. With this method, a fluid that includes the fuel, at least one of steam and a carbon dioxide-containing gas, and an oxygen-containing gas, is supplied to a reforming reaction region, and with the thermal decomposition index temperature of the fuel, which is determined by the type and the concentration of the hydrocarbons having at least two carbon atoms that make up the fuel, serving as an upper limit temperature of the reforming reaction region, the fluid is brought into contact with the reforming catalyst to produce the reformed gas.
US08486164B2 Evaporator and fuel reformer having the same
An evaporator and a fuel reformer having the same. The evaporator includes a wall arrangement having a circumferential wall and a bottom wall, the circumferential wall and the bottom wall defining (or surrounding) an evaporation chamber; an inlet provided at one side of the evaporation chamber; an outlet formed in the bottom wall; and a barrier at (or surrounding) the outlet and projected from the bottom wall to the inside of the evaporation chamber.
US08486158B2 Method and device for continuously producing a crystallite having a constant particle size distribution
The invention proposes a method and a device for continuously producing a crystallite, wherein a metered amount of seed crystals is fed continuously to the internal solution circuit of a crystallizer, in particular a DTB crystallizer, through a crystallization seed line from a seed generator preferably designed as a flash crystallizer. The amount of seed crystals fed is controlled by an electronic control system as a function of a measured value determined by a sensor, said value being representative of the particle size distribution of the crystallites in the solution in the internal circuit in the crystallizer. By way of a line, the seed generator receives a partial stream of the external solution circuit of the crystallizer, said external circuit being routed through a line. Excess fine crystalline suspension can be fed back to the external circuit from the seed generator by way of a return line.
US08486157B2 Process for the phase transformation of substances
Process for the phase transformation of substances and mixtures of substances, in which the substance or the mixture of substances is introduced into a plasma reactor, the substance or the mixture of substances is converted into the higher-energy phase and the product is removed in gaseous form from the plasma reactor. The process can be used for the sublimation of metal salts, metal nitrates and/or metal alkoxides and other vaporizable metal-organic compounds.
US08486155B2 Fistula repair plug having multiple layers
A surgical device is operable to coextrude a multilayered biocompatible tissue repair plug in situ within a lumen in a patient. The device comprises a handle, a shaft extending from the handle, a plurality of conduits extending through the shaft, a plurality of media chambers, and an actuator. At least one of the media chambers contains a suspension of at least one tissue fragment having at least one viable cell in a biocompatible carrier. The actuator is operable to cause media in each of the chambers to be urged through, and expelled from the orifice of, the conduit in communication therewith. The orifices are located at the distal end of the shaft such that media from the media chambers may be ejected into a lumen in a patient in order to form a multilayered biocompatible tissue repair plug in situ. The conduits and their orifices are all coaxially aligned.
US08486151B2 Cotyloid element of a hip prosthesis, and total hip prosthesis comprising same
The invention relates to a cotyloid component of a hip prosthesis, said cotyloid component being hollow and in the form of a cup whose outer part has a thread allowing it to be fixed in the iliac bone, said thread being a discontinuous self-cutting double thread (20, 21), and said cotyloid component having a flattened upper pole (1), a coating that promotes osseointegration on its outer face (10), and a concave, substantially hemispherical and polished inner surface (11), characterized in that: (a) the pitch of the threads (20, 21) decreases from the upper pole (1) towards the equatorial periphery (3) of the cotyloid component, (b) the thicknesses of the threads (20, 21) increase from the upper pole (1) of the cotyloid component towards its periphery (3), (c) the crest of the threads (20, 21) is sharp towards the pole (1) of the cotyloid component and rounded or substantially trapezoidal towards the equatorial periphery (3) of the cotyloid component.
US08486147B2 Posterior spinal device and method
An intervertebral joint assembly includes an upper support and a lower support, each of which has two or more components. The upper and lower support components are arranged in situ to form the upper and lower supports, respectively. By arranging the supports in situ, the supports can be introduced from the back of the patient, for example with an arthroscope. Each of the upper and lower supports has a surface adapted to engage a vertebra and a surface adapted to engage the other support or an intermediate member to form an articulate joint which articulates the joint assembly. In some embodiments, the components of the upper and lower supports are assembled in situ, for example with pivoting, telescoping or bending, to form the upper and lower supports, respectively. The supports can be attached to vertebrae with pedicles screws, and/or other anchors attached to the supports.
US08486145B2 Flexure limiter for spinal prosthesis
Apparatus including a first spinal prosthetic member that may articulate with a second spinal prosthetic member, the first and second spinal prosthetic members flexing relative to one another about a lateral-medial axis corresponding to a lateral-medial axis of a body, and a flexure limiting member attached to the first and second spinal prosthetic members that limits flexure about the lateral-medial axis.
US08486137B2 Streamlined, apical delivery system for in situ deployment of cardiac valve prostheses
A system for implanting a heart valve prosthesis in a patient's heart includes a balloon expandable, tissue, stented heart valve, and an apical valve delivery device for delivering the stented heart valve to a target site in the patient's heart. The delivery device includes an inflation balloon module for expanding the stented heart valve prosthesis, markers on the delivery device to assist in location of the delivery device at an appropriate location, and a streamlined cap.
US08486136B2 Mitral spacer
A heart valve implant may include a shaft and an anchor configured to be coupled to an end of the shaft. A spacer may be coupled to a portion of the shaft and comprise a plurality of individual segments including a first and at least a second individual segment. The first segment may be coupled to the shaft. The second segment may be coupled to at least a portion of an exterior surface of the first segment and may have at least one cross-section dimension which is greater than an internal cross-sectional dimension of a delivery lumen. Additional segments may be coupled to an inner, adjacent segment. The segments may include a collapsible body portion to facilitate percutaneously delivery through a lumen. The segments may define an outer surface of the spacer configured to interact with at least a portion of at least one cusp of a heart valve to at least partially restrict a flow of blood through the heart valve in a closed position.
US08486135B2 Implantable medical devices fabricated from branched polymers
This invention relates to implantable medical devices, such as stents, fabricated from hyperbranched-like polymers, comb-like polymers, star polymers, dendrimer-like star polymers, dendrimers, and mixtures thereof.
US08486134B2 Bifurcation treatment system and methods
A catheter assembly configured for treatment of a vessel bifurcation. The catheter assembly includes a catheter shaft and first and second balloons. The second balloon extends radially outward relative to the first balloon when expanded. A valve arrangement controls expansion of the second balloon. Portions of the valve arrangement can be positioned at proximal and distal end portions of the catheter shaft. Typically, the first balloon is expanded followed by expansion of the second balloon. A stent having a lateral branch opening is operatively mounted to the first balloon. The second balloon is configured to extend through the lateral branch opening when the second balloon is expanded.
US08486133B2 Stent having helical elements
An expandable stent comprised of a plurality of helical segments is disclosed. In one embodiment, the stent is generally cylindrical in shape having a cylindrical axis, and the comprises at least two a first and second set of helical segments. The helical segments in the first set are substantially parallel and have a first pitch forming a first helical angle with respect to the cylindrical axis. The helical segments in the second set are also generally parallel to each other and form a second pitch that differs from the first pitch, thereby forming a second helical angle with respect to the cylindrical axis. In an alternative embodiment, the stent comprises one set of helical segments and a plurality of circumferential elements that are joined together by the helical segments to form a plurality of cylindrical elements which are joined together to form a stent body. The stent may also have endzones.
US08486132B2 Devices and methods for controlling expandable prostheses during deployment
A catheter for delivering a prosthesis to a treatment site in a body lumen comprises an elongate flexible member and a sheath slidably disposed thereover. A plurality of self-expanding tubular prostheses are carried in axially spaced apart locations along the elongate member, within the sheath. The prostheses may be selectively interlocked with one another and are constrained by the sheath in a radially contracted configuration. The prostheses are separately releasable from the sheath when the sheath is retracted relative to the elongate member. The catheter also has a pusher member slidably disposed along the elongate member within the sheath. The pusher is adapted to move past the prostheses in a first direction without displacing the prostheses, while in a second direction the pusher engages a selected prosthesis so as to move the prosthesis with the pusher to interlock the selected prosthesis with a second prosthesis.
US08486130B2 Two balloon staged stent expansion
A catheter with two balloons for implanting a stent without flaring at the ends of the stent during implantation has an outer balloon overlying an inner balloon. The length of the inner balloon is shorter than the length of the outer balloon and shorter than a stent which is mounted over both balloons. Upon inflation of the inner balloon, the inner balloon expands only the center of the stent. After the center of the stent is expanded, further application of pressure bursts the inner balloon allowing application of pressure to the outer balloon. The outer balloon is then inflated, expanding the ends of the stent.
US08486129B2 Method for prosthetic repair of body passages
A prosthesis that resiliently engages a body passage includes an annular clamping ring which may be folded along a diametric axis for insertion into the body passage. The clamping ring is adapted to resiliently spring outwardly, once in position inside the body passage, and to be continually resiliently biased against the interior surface of the body passage. One or more of the clamping rings may be attached to opposed ends of a tubular graft. The rings and connected graft may be positioned in the body passage using an applicator which selectively permits expansion and/or in some embodiments contraction of the annular ring in position within a body passage. Alternatively a retaining member may be used to retain the annular ring in a compressed condition until it is in a desired position within a body passage.
US08486126B2 Lighting system for use in light therapy
A method and device for light color therapy, which is a method for simultaneously exposing specific surface regions of the human body to light of specific but possibly different frequencies, temporal characteristics and polarization. The device is constructed to match anatomical details of the human body such as to apply the simultaneous local light exposures to the desired body regions and to compensate for possible movement of the head, thereby minimizing the time required for a single treatment.
US08486123B2 Micro-organism-reducing device
The invention relates to a micro-organism reducing device, comprising a radiation device which is provided with a light source, a photosensitive substance which treats the area to be treated and is irradiated by said light source. The aim of said invention is to configure said device in such a way that it is possible to carry out an efficient and controllable treatment by means of operationally low-cost and easily handling apparatus. For this purpose, the inventive device comprises at least one applicator provided with a fiber-optic waveguide. In addition, said applicator and radiation device respectively comprise corresponding liaison bodies contacting one of them in such a way that the light from the light source is emitted towards the treated area by means of the fiber-optic waveguide.
US08486117B2 Multi-axial bone plate system
An orthopedic bone plate system having a bone plate for placement adjacent one or more vertebral bodies. The system further includes a locking element including a compression member and a fixation member wherein the compression member includes an aperture and at least one deformable portion. A bone fastener is also included in the present system which includes a bone engaging portion and a stem portion. The stem is capable of being slidably received within the aperture of the compression member while the locking member is capable of being received within an aperture of the bone plate. As the compression member is brought into proximity of a vertebral body along the longitudinal axis of the bone fastener, an increasing force is exerted against the fixation member and translated to the bone plate. The resultant force translated back to the fixation member to the compression member which causes the deformable portion of the compression member to clamp the bone fastener relative to the bone plate.
US08486116B2 Variable angle locking screw
The present disclosure relates to retention devices for surgical procedures and, more specifically, relates to variable angle retention devices to mount bone to a plate material.
US08486107B2 Method of sealing tissue using radiofrequency energy
A forceps for sealing tissue includes a housing having one or more shafts that extend therefrom configured to support an end effector assembly at a distal end thereof. The end effector assembly includes a pair of opposing jaw members each having a sealing plate with tissue engaging surfaces adapted to connect to an electrosurgical energy source. At least one of the sealing plates includes a predetermined surface geometry defined thereon that imprints a corresponding surface geometry onto the tissue seal to facilitate sealing the tissue with a foreign material when electrosurgical energy is applied to the forceps.
US08486105B2 Vascular device for emboli and thrombi removal and methods of use
Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device disposed on a guidewire comprises a support hoop disposed from a suspension strut. Alternately, a support hoop having an articulation region may be directly connected to a region proximate the distal end of the guidewire. A blood permeable sac is affixed to the support hoop to form a mouth of the blood permeable sac. The support hoop is disposed obliquely relative to the longitudinal axis of the guidewire and is capable of being properly used in a wide range of vessel diameters. The vascular device collapses during removal to prevent material from escaping from the sac. A delivery sheath and introducer sheath for use with the vascular device of the present invention are also provided.
US08486101B2 Expanding vaso-occlusive device
This is a device for occluding a space within the body. In particular, the device comprises an expandable member, an inner member and one or more stop elements. The devices may be placed in a desired site within a mammal to facilitate the formation of an occlusion.
US08486099B2 Systems and methods for removal of intravascular leads
Systems and methods for extraction of implanted articles are disclosed. According to aspects illustrated herein, there is provided a system for extraction of an implanted article that includes an elongated member and a guide member disposed at a distal section of the elongated member. The guide member may define a pathway through which an implanted article can be securely received. The device can further include a dissection mechanism, coupled to the elongated member and designed to be positioned about the implanted article, for dissecting a fibrous adhesion about the implanted article.
US08486096B2 Dual purpose surgical instrument for cutting and coagulating tissue
In one general aspect, various embodiments are directed to an ultrasonic surgical instrument that has an ultrasonic blade that protrudes from an ultrasonic transducer assembly. In some embodiments, the ultrasonic blade coaxially extends through a rotatable tissue cutting blade that is rotatably supported by a housing that supports the ultrasonic transducer assembly. In other embodiments, the ultrasonic blade and the tissue cutting blade are both selectively rotatable relative to the housing. In yet other embodiments, the tissue cutting blade and the ultrasonic blade are supported relative to each other in separate sheaths attached to the housing.
US08486094B2 System and method for providing an obturator for enhanced directional capabilities in a vascular environment
An apparatus for assisting in a vascular procedure includes an obturator operable to be mounted on a medical device to guide the medical device into a targeted region, whereby the obturator is substantially blunt such that it exhibits a snag-resistant property. In alternative embodiments, the apparatus includes an interface element operable to be used in conjunction with the obturator and to engage an interface of the targeted region such that pressure is maintained within the targeted region. The interface element includes a convex portion that operates to seat the interface element at a selected location. The interface element is substantially transparent and includes a magnification element that magnifies materials underlying the interface element. In other embodiments, the apparatus includes a tray operable to provide a mold for forming the obturator, which may include a gas, water, sugar, clotted blood, a gelatinous material, a protein, a saline solution, or dry-ice.
US08486090B2 Surgical instrument support
The present invention generally provides a surgical instrument support for securing a surgical instrument in a fixed position in a surgical environment having a magnetic field. The surgical instrument support has a mounting clamp, a tightening mechanism, a plurality of mating arm segments, an end member with a connector to secure the surgical instrument thereto, and a wire extending from the tightening mechanism to the end member. The wire can be tightened to secure the mating arm segments in a desired position for the surgeon. In one embodiment all of the components of the surgical instrument support are made of a non-magnetic material, preferably titanium or a titanium alloy. In another embodiment the connector of the end member can be removed when the surgical instrument support is in both the rigid or actuated configuration and the untightened or non-actuated configuration.
US08486084B2 Surgical slap hammer
A slap hammer including an adjustable striking member and a releasable retaining mechanism for releasably retaining a sliding weight is disclosed. One described slap hammer comprises a guide rod having a first end and a second end; a striking member coupled to the second end of the guide rod and movable relative to the first end of the guide rod; a sliding weight slidable along the guide rod between the first end of the guide rod and the striking member; a biasing element positioned between the sliding weight and the first end of the guide rod, the biasing element biasing the sliding weight towards the second end of the guide rod; and a releasable retaining mechanism for releasably retaining the sliding weight against the action of the biasing element.
US08486083B2 Methods and instrumentation for inserting intervertebral grafts and devices
Instruments for inserting an implant in a space between adjacent bony portions include upper and lower guide members separated by a spreader with the implant positioned forwardly of the spreader. The spreader is movable forwardly between the guide members with a drive member to position the implant in a space between the bony portions. The spreader contacts the adjacent bony portions to facilitate withdrawal of the inserter instrument when the implant is positioned in the space.
US08486082B2 Apparatus for dimensioning circumference of cavity for introduction of a prosthetic implant
A device for dimensioning a circumference of a cavity includes a body with a lumen and a distal aperture. The device also includes a longitudinal member extending through the lumen with a distal end and a proximal end. The longitudinal member is capable of slidable movement through the body between retracted and advanced positions. The device also includes a flexible member adapted to conform to a circumference of a cavity contained, e.g., in an intervertebral disc space. The flexible member is operatively connected to a longitudinal member such that upon retraction of the longitudinal member the flexible member retracts into the lumen. When the longitudinal member is moved toward the advanced position, the flexible member is advanced out of the lumen and expands to conform to a dimension which approximates the circumference of the cavity. An apparatus is provided which includes a device for dimensioning a circumference of a cavity and an access member for facilitating conduction of the device to a surgical site, the device adapted and configured to fit within the access member. A kit is provided which includes a working tube incorporating a vertebral distractor, a spreader for assisting and maintaining the vertebral distractor in a distracted configuration, a closing tube for maintaining the working tube in a closed configuration, and a cavity circumference measuring device.
US08486081B2 Implant insertion device and method
A method and system for insertion of an implant is disclosed. One embodiment of a system for use in implanting a spinal prosthesis incorporating principles of the invention includes an insertion assembly housing with a channel extending from a distal end portion to a proximal end portion, a gripper having a prosthesis coupling portion for coupling with a spinal prosthesis and an end portion, and a coupler member having a gripper coupling portion rotatably positioned within the channel and configured to couple with the end portion of the gripper within the channel.
US08486079B2 Method and apparatus for remote alignment of a cut guide
A method and apparatus for remote alignment of a cut guide. The cut guide may be positioned on a base which is remote from a surgical site and positioned on a docking station. An alignment jig is removably positioned on a bone and is used to provide alignment information to the docking station. The docking station remotely aligns the cut guide relative to the base. Thereafter, the cut guide and base are removed from the docking station and positioned on the bone in place of the alignment jig. A surgical procedure using the cut guide may then be completed.
US08486074B2 Surgical allograft bone plug cutting tool assembly and method of using same
The invention is directed toward a surgical kit having component parts capable of use to prepare a cartilage implant plug from allograft condyle. The kit comprises a sizing gauge used to measure surface of the allograft condyle so that a cartilage implant plug can be removed that corresponds to the contours of the defect site excised on a patient. An adjustable guide member is mounted in a fixed orientation over the allograft condyle in which a cylindrical graft cutter for cutting a cylindrical allograft bone plug having a cartilage cap and a bone end portion. A chamfering tool is used for chamfering the bone end of the allograft bone plug.
US08486071B2 Short pin for taking care of epiphysis fractures
A short nail for treatment of an epiphyseal fracture close to a joint in a long bone includes a two part nail supporting body comprising a main body having a transverse through-bore and releasably attached to a stub body. The stub body has an end that has a diaphyseal slant. The stub body and the lateral slant form part of a diaphyseal anchor which is attachable to the main body via the stub body and which has a flat connecting web that has an oblique orientation and ending laterally in a plane with the diaphyseal slant. A connecting device rigidly and releasably connects the main body and the stub body together. An anchoring device fixes the flat web in flat abutment against the diaphysis. A fixation pin is insertable into the transverse through-bore in a crossed arrangement with, and at a fixed angle to, the supporting body in the state of treatment of the fracture. The fixation pin includes a mechanism to protect against axial movement of the pin.
US08486069B2 External fixator
A fixator for use in the reconstruction of acute, chronic and traumatic injuries to the upper and lower extremities. The fixator has a unique clamping system that allows for the snapping in of pins and rails, and for multi-planar fixation of bones.
US08486065B2 Radio-frequency ablation system and method using multiple electrodes
Efficient ablation with multiple electrodes is obtained by rapidly switching electric power to the electrodes. In this way, shielding effects caused by the field around each electrode which would otherwise create cool spots, are avoided. Complex inter-electrode current flows are also avoided.
US08486064B2 Electrosurgical device having floating-potential electrode and curvilinear profile
Disclosed herein are embodiments of an electrosurgical device that include one or more floating electrodes and are specifically adapted to remove, cut, resect, ablate, vaporize, denaturize, drill, coagulate and form lesions in soft tissues, with or without externally supplied liquids, preferably in combination with a resectoscope, particularly in the context of urological, gynecological, laparoscopic, arthroscopic, and ENT procedures. Specific adaptations for urological and gynecological applications, for example kidney stone removal and BPH treatment, are also described.
US08486057B2 Tissue impedance measurement using a secondary frequency
A microwave ablation system includes a generator including a first energy source, a second energy source and a diplexer, the diplexer multiplexes a first energy from the first energy source and a second energy from the second energy source. The system also includes a cable including a center conductor and an outer sheath where the multiplexed energy is transmitted through the center conductor. In addition an antenna is provided that is operable to receive the multiplexed energy from the center conductor and to deliver the multiplexed energy to a region of tissue. The outer sheath acts as a return path of the second energy to the second energy source. A sensor is also provided that measures at least one parameter of the second energy generated by the second energy source and the second energy returned from the region of tissue.
US08486054B2 Optometrist client
A method of providing optometric parameters for an optometric procedure includes locating patient identification information on a central data storage by transmitting a search query from a computing device communicating with the central data storage. The search query generates a result set containing at least one patient having patient identification information substantially matching the search query. From the result set, a patient undergoing the optometric procedure is selected. An input form for this patient is then displayed with input fields corresponding to each of the optometric parameters. A qualified collector obtains the measurement values for the optometric parameters and inputs them into respective input fields. A data record containing the measurement values and the patient identification information is generated and transmitted to the central data storage. The data record can then be transmitted to a planning tool communicating with the central data storage for performing the optometric procedure.
US08486049B2 Valve connector for medical lines
A valve connector for medical infusion lines including a tubular body (1) with an inlet (4) and an outlet (10), an internal hollow spike (2), and a sealing member (3) including an elastic head (14) with pre-slit (17) normally kept in an undeformed closed condition within the inlet (4). The outlet (10) comprises a pierceable injection point (22) coaxially facing the hollow spike (2).
US08486048B2 Position confirming catheter
A catheter includes an inner layer, an outer layer, a reinforcement layer located between the inner layer and the outer layer, and a marker composed of a contrast material for confirming the position of the distal end portion of the catheter from outside the living body. The reinforcement layer is composed of a spiral first filamentous member, with a gap provided between those portions of the first filamentous member which are adjacent to each other along the longitudinal direction of the catheter. The marker is formed by spirally winding a second filamentous member having a filament diameter smaller than the gap, and has a portion in close contact with the inner layer in the gap.
US08486047B2 Packaged medical device
The present disclosure provides a packaged medical device including a container for receiving a medical device having a passageway defined therein and a port for permitting the sterile passage of an agent between the outside of the container and the passageway defined within the medical device.
US08486042B2 Refastenable absorbent article and a method of applying thereof
Absorbent articles such as disposable diapers, incontinent briefs, diaper holders, training pants and the like, having elastomeric flaps and a fastening system that provides the user with options as to how the absorbent article may be fitted to and removed from the wearer. The absorbent articles can be pulled on and/or off as a pant. This feature is provided by the ear panels which maintain sufficient tension to hold the diaper on the wearer throughout the period of use without harming the wearer's skin, while providing enough stretch to allow the diaper to be pulled up or down over the wearer's hips. The fastening system is refastenable for convenience yet strong enough to maintain the diaper in a fastened configuration without becoming detached if the diaper is pulled on or off the wearer.
US08486037B2 Absorbent article having releasable flap covers
An absorbent article which can be fixed to an undergarment without creating wrinkles, a release paper sheet is composed of a first release paper sheet covering a main body displacement-preventing adhesive layer and wing displacement-preventing adhesive layers and a pair of second release paper sheets respectively covering seat displacement-preventing adhesive layers. When the article is applied to shorts, the first release paper sheet is removed, and the main body displacement-preventing adhesive layer and the wing displacement-preventing adhesive layers of the absorbent article are fixed to the shorts that are pulled down. Then, the shorts are pulled up and worn, and the second release paper sheets are removed to fix the seat displacement-preventing adhesive layers to the shorts.
US08486035B1 Ostomy undergarment
A medical undergarment system effective for supporting an ostomy system consists of a first diagonal catheter channel, a second diagonal catheter channel, a first vertical catheter channel, and a second vertical catheter channel. The system consists of tubing, a base undergarment, and a fluid bag. The medical undergarment system provides a comfortable yet stable ostomy system that can easily be slipped on and off by a user. The system enables convenient and easy removal of bodily fluid when using a catheter.
US08486033B2 Application of polymeric materials to screens to facilitate hemostasis and wound healing
This invention relates in general to a method and device for facilitating hemostasis and wound healing. In particular, the invention relates to the device comprising a polymeric material disposed on a scaffold that facilitates hemostasis and wound healing. Specifically, the invention contemplates the use of such scaffolds in conjunction with a negative pressure device.
US08486032B2 Reduced-pressure treatment systems and methods employing debridement mechanisms
Reduced-pressure treatment systems and methods are disclosed that employ debridement mechanisms to remove unwanted tissue. In one instance, a reduced-pressure treatment system for treating a tissue site on a patient includes a manifold member for distributing reduced pressure to the tissue site, a support member for disposing proximate the tissue site and the manifold, and a debridement mechanism coupled to the support member. The debridement mechanism is for debriding the tissue site. The system further includes a sealing drape for placing over the tissue site and manifold member. The sealing drape is operable to form a fluid seal over the tissue site and manifold member. The system also includes a reduced-pressure subsystem for delivering a reduced pressure to the sealing drape. The system may further include a chemical-debridement subsystem. Other systems, manifolds, and methods are disclosed.
US08486030B2 Hand held skin treatment spray system with proportional air and liquid control
A spray nozzle system includes separate air outlets to deliver one or more streams of supplemental warming or drying air. The air may be applied while spray is emitted from the nozzle to increase the spray cloud temperature, or may be applied for warming or drying before or after the spray application, with the spray turned off. In the case of air-atomizing nozzles, the air is delivered through low pressure ports separately from the atomizing or pattern shaping air to minimize the expansion cooling effect. In another implementation, the air is redirected from the nozzle using a control valve which proportions the amount of airflow directed for atomization, pattern shaping and drying.
US08486028B2 Tissue marking apparatus having drug-eluting tissue marker
A tissue marking apparatus includes a marker introducer that has a cannula and a stylet. The cannula has a lumen and a marker exit port. The stylet is slidably received in the lumen. The stylet has a distal end. A tissue marker is configured to be received in the lumen distal to the distal end of the stylet. The tissue marker is a drug-eluting tissue marker for marking a site in a tissue mass, and has a drug-eluting portion having a drug for release to the site and a material that can be imaged using an imaging technique.
US08486026B2 Intravenous catheter anchor system and method
An improved anchor system and method for holding an intravenous catheter to the patient's body that is easier to clean. The system includes an intravenous catheter having a main line, a yoke attached to the main line, an elastic band made of non-porous material, and a neck lanyard with a clamp. During use, the elastic band is positioned around the two lumens and twisted into a figure eight configuration, forming two loops. Each lumen is extended into one of the elastic band's two loops. The lanyard's clamp is then attached to the crossover section of the elastic band located between the two loops. The elastic band is sufficient in size and resiliency so that when the clamp is released, each loop may be stretched so the lumens may be removed so the elastic band may be replaced.
US08486022B2 Needle catheter with an angled distal tip lumen
A needle catheter configured for injecting an agent into a wall of a patient's body cavity, which directs a needle from the distal tip of the catheter into the wall of the body cavity at an angle relative to the axis of the shaft. The resulting angled injection pathway improves the retention of the agent in the body cavity wall, while keeping a distal section of the catheter substantially perpendicular to the body cavity wall for optimal push against the tissue at the injection site.
US08486018B2 Adhesive and peripheral systems and methods for medical devices
A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.
US08486014B2 Spiral perfusion dilatation balloon for use in valvuloplasty procedure
A balloon dilatation catheter for use in a valvuloplasty procedure includes a catheter shaft and a spiral perfusion balloon mounted thereon. The perfusion balloon is formed from an inflatable tube that is in fluid communication with a catheter shaft inflation lumen. The inflatable tube is coiled into a series of windings that in an inflated configuration form a cylindrical or hourglass profile. In the inflated configuration, inner surfaces of the coiled windings of the inflatable tube define a perfusion lumen to allow blood flow through the perfusion balloon. Adjacent windings may be secured together with a flexible adhesive and/or a support weave formed from one or more filaments of material that criss-crosses between the adjacent windings along substantially the entire length of the spiral perfusion balloon.
US08486013B2 Balloon catheter having coating
An embodiment of the present invention relates to a balloon catheter, which has a drug-releasing coating and/or cavity filling on at least parts of the outwardly facing surface of the dilatable balloon, characterized in that the coating comprises a drug and a gelatin mixture, the gelatin components of the gelatin mixture comprising 10-90 wt. % high-bloom gelatin having a gel strength of ≧250 bloom and 90-10 wt. % medium-bloom gelatin having a gel strength of ≧50 to <250 bloom, the specifications in wt. % relating to the total weight of the gelatin components of the gelatin mixture.
US08486012B1 Apparatus to prevent reperfusion injury
Embodiments of a method and apparatus to prevent reperfusion injury. In one embodiment, blood flow proximal to a lesion is occluded. An infusion catheter is advanced to a region distal to the lesion and an anti-reperfusion injury drug is delivered. The lesion may then be treated with a dilating device to reintroduce blood flow to the region distal to the lesion.
US08486011B2 System and a method for inflating an inflatable element with a liquid inflating medium and a balloon catheter inflated by the system and method
A balloon of a balloon catheter is inflated with a liquid inflating medium by a syringe through a flow line. Air in the flow line and the balloon is displaced into a return line. The balloon is deflated by drawing the liquid inflating medium from the balloon along with the air in the return line into the syringe where the air is trapped in the syringe. The balloon is reinflated and deflated by the syringe until the level of air in the liquid inflating medium has been reduced to a predefined level. A first non-return valve and a second non-return valve are provided in the flow and return lines, so that the liquid inflating medium is prevented from flowing from the balloon to the syringe in the flow line and from the syringe to the balloon in the return line.
US08486010B2 Bendable catheter
The bendable catheter includes a flexible tubular main tube; a bendable part having a longitudinal axis and an internal space formed along the longitudinal axis, and being capable of being bent; a first coil provided in the internal space along the longitudinal axis; a second coil having a central axis extending parallel to a central axis of the first coil and provided adjacent to the first coil in a space formed between the bendable part and the first coil; and a bending manipulation wire arranged within the second coil, being capable of bending the bendable part, and having one end fixed to the bendable part.
US08486009B2 Systems and methods for steering catheters
Systems and methods for steering catheters to facilitate advancing the catheters through the body, wherein the catheters employ multiple steering stages, each of which can move in multiple planes. The steering stages are independently controlled to enable them to form complex shapes. In one embodiment, the steerable catheter includes an elongated catheter body with the steering stages incorporated into the distal end of the catheter. The steering stages may incorporate multiple memory wires and corresponding heating elements that control the temperatures of the memory wires and consequently control the shapes of the wires and the steering stages in which they are embedded. The catheter may be any type of catheter (e.g., a lumen catheter) and may include features that enable the catheter to perform functions such as delivering therapies (e.g., ablation) to target tissues within the body.
US08486006B2 Medical injector with button activation
A medical injector is provided herein which includes a body; a slidable button at least partially disposed in the body; a displaceable plunger disposed in the body; a spring disposed to advance the plunger; and, a releasable retainer for retaining the plunger in a first state against force of the spring. Upon a predetermined extent of sliding movement of the button, the button engages the releasable retainer so as to cause the releasable retainer to release the plunger thus allowing the spring to advance the plunger. Advantageously, the subject invention provides a medical injector having an automated plunger drive which is triggered upon button activation, thereby minimizing premature or failed activations.
US08486005B2 Method and system for detecting an occlusion in a tube
Systems and methods for detecting an occlusion in a fluid delivery device are disclosed. The system includes a fluid delivery tube, an occlusion detection sensor configured to be coupled to the fluid delivery tube and further configured to detect occlusion within the fluid delivery tube. The fluid delivery tube includes an occlusion detection portion. The occlusion detection sensor is further configured to detect alteration of a shape of the occlusion detection portion when at least one condition occurs within the fluid delivery tube.
US08486004B1 Dressing having integral antimicrobial
A dressing having integral antimicrobial includes a transparent film layer having a top side, an opposite bottom side, and an insertion site viewing portion. The dressing also includes an antimicrobial member having a top side and an opposite bottom side. The antimicrobial member top side is adhered to the film layer bottom side in the insertion site viewing portion. The antimicrobial member includes at least one pair of elongated, spacedly disposed portions defining a slot therebetween. A zone of inhibition defined by the antimicrobial member covers an entire area of the slot between the member portions.
US08486003B2 Inserter having two springs
The invention relates to an inserter for a medical device e.g. an infusion set or the like for intermittent or continuous administration of a therapeutical substance, such as e.g. insulin. The inserter comprises a needle hub comprising an insertion needle and two elastic elements assuring automatic insertion and automatic retraction of the insertion needle. Activation of the first elastic element (11) cause a penetrating member (6A) to be inserted sub- or transcutaneously into the skin of a patient, and the second elastic element (12) cause the penetrating member (6A) to be retracted from the skin of the patient. The first elastic element (11) is in an unloaded state before activation and upon activation the first elastic element (11) energizes the second elastic element (12).
US08486002B2 Drug delivery devices and methods with collimated gas stream and release-activatable tape
Drug delivery devices and methods are provided for delivering a substance into a human or animal tissue. The device includes a gas source comprising a gas or capable of selectively producing a gas. The device also includes a drug source positioned and configured to release a drug into the gas. The drug source includes a release-activatable tape having the drug disposed thereon. The device also includes a first collimator fluidly connected with the gas source. The first collimator, which has an inlet end and an outlet end, is adapted to form a collimated gas stream comprising the drug in the gas.
US08486000B2 Ocular pressure regulation
This invention comprises a flexible ocular device for implantation into the eye formed of a biocompatible elastomeric material, foldable to a diameter of 1.5 mm or less, comprising a fluid drainage tube having at one end a foldable plate adapted to located the device on the inner surface of the sclera in a suprachoroidal space formed by cyclodialyis, said drainage tube opening on to the disc at one end and opening to the anterior chamber when implanted into the eye at its other end, so as to provide aqueous pressure regulation. Also provided are methods for the treatment of glaucoma utilizing the flexible ocular device, and an ocular pressure spike shunt.
US08485998B2 Blood treatment system
A blood treatment system including a computer with a program library containing data sets for the functional processes of blood treatment apparatus. The computer is used to generate data sets with the aid of a catalog of questions to be responded to interactively. In this manner, data sets can be generated corresponding to the individual requirements. The selecting of a data set can also be performed corresponding to the individual needs of the users and patients, respectively.
US08485995B1 System and method for thermal compression therapy
A method for providing a combined DVT and compression therapy to a patient is provided. The method includes providing a control unit configured to condition heat transfer fluid and to selectively provide a compressed gas, providing a thermal compression device that is mountable to a select portion of the patient, and programming the control unit to supply heat transfer fluid to the thermal compression device and to supply compressed gas to the thermal compression device.
US08485993B2 Switched resonant ultrasonic power amplifier system
A switched resonant power amplifier system for ultrasonic transducers is disclosed. The system includes an amplifier that receives and processes a driver output signal for generating a drive signal that is provided to an ultrasonic device for controlling output of the ultrasonic device. An output control circuit receives and processes a signal related to a feedback signal generated by the ultrasonic device and a divider reference signal, and generates a compensated clock signal that is adjusted for at least one of phase and frequency differences between the received feedback signal and the divider reference signal. A compensated drive circuit receives and processes the compensated clock signal for generating the divider reference signal, and for generating the driver output signal.
US08485991B2 Vacuum assisted lancing system with system and method for blood extraction and masking pain
A method of masking pain resulting from a lancing system can include moving a first portion and a second portion of a lancing assembly in a first direction, stopping the first portion from further moving in the first direction, thereby causing a first vibration, allowing the first portion to move in a second direction while the second portion continues moving in the first direction, and lancing a surface with the first portion while the first vibration is occurring. A system for lancing a surface and masking resulting pain may include a device body having an end adapted to sealingly engage the surface, structure for creating a first portion of a vacuum, structure for causing a vibration, and a lancing mechanism adapted to lance the surface while the first portion of the vacuum and the vibration are acting on the surface.
US08485988B2 Tissue excision device
A biopsy device includes a coring cannula, a retract stylet, and a localization needle. The coring cannula has a longitudinal axis and a shaft centered on the axis. The stylet has a tip containing at least one blade and a central passage. The localization needle has a channel and is slidably disposed within the central passage. A drive mechanism rotates the cannula and moves the cannula in a direction parallel to the longitudinal axis of the cannula. A guide element has a first end and a second end and is slidably disposed within the channel of the localization needle. The guide element is movable from a first position to a second position within the localization needle.
US08485985B2 Physiological sensor delivery device and method
An intravascular sensor delivery device for measuring a physiological parameter of a patient, such as blood pressure, within a vascular structure or passage. In some embodiments, the device can be used to measure the pressure gradient across a stenotic lesion or heart valve. For example, such a device may be used to measure fractional flow reserve (FFR) across a stenotic lesion in order to assess the severity of the lesion. The sensor delivery device has a distal sleeve configured to pass or slide over a standard medical guidewire. Some distance back from the sensor and distal sleeve, the device separates from the guidewire to permit independent control of the sensor delivery device and the guidewire. The sensor delivery device can be sized to pass over different sizes of guidewires to enable usage in coronary and peripheral arteries, for example. The sensing mechanism (sensor) can be a fiber optic pressure sensor, such as a MEMS-based Fabry-Perot fiber optic pressure sensor, for example, or could employ some other technology, e.g., MEMS capacitive or piezoresistive sensor.
US08485974B2 Multiple-frequency ultrasonic phased array driving system
An apparatus for sonicating a patient includes an ultrasound array having a plurality of transducers; a driving module for driving said transducers; and a control kernel for causing said driving module to drive said transducers concurrently at two different frequencies.
US08485970B2 Surgical access device
Various devices are provided for allowing multiple surgical instruments to be inserted through a single surgical access device at variable angles of insertion, allowing for ease of manipulation within a patient's body while maintaining insufflation. Safety shields and release mechanisms are also provided for use with various surgical access devices.
US08485968B2 Endoscope
A rigid, rod-shaped endoscope for medical applications includes a distal end having a light-permeable distal window and a light outlet disposed adjacent to the distal window, which includes a device configured to prevent the incidence of stray light onto sides of the deflection prism facing the distal window. An endoscope shank includes a plurality of telescoping hollow tubes. An inner fixed optical tube includes a moveable optical deflection prism and an optical system configured to transmit light beams. The optical deflection prism is mounted rotatably on a shaft that is disposed at a right angle to a longitudinal axis of the endoscope. At least one moveable sliding tube is configured to move relative to the inner fixed optical tube in the direction of the longitudinal axis of the endoscope using magnetic forces generated by a plurality of moveable permanent magnets.
US08485967B2 Endoscopic imaging device and endoscope apparatus having a configuration to prevent condensation
An endoscopic imaging device includes an objective optical system, an imaging element, a transmissive protective substrate, an optical member, and a circuit board. The objective optical system imports observation light from a subject. The imaging element captures an image of the observation light. The transmissive protective substrate is disposed on an imaging surface of the imaging element with an air gap interposed therebetween. The optical member is disposed between the objective optical system and the transmissive protective substrate to guide light from the objective optical system to the imaging surface. The circuit board is disposed so that an area where an electronic component is mounted faces the optical member and the electronic component is brought into contact with an outer surface of the optical member.
US08485965B2 Endoscope main body and endoscope
An endoscope main body constituting an endoscope in a state in which an elongated detachable observation optical system is attached to the endoscope main body, and in a proximal end of an insertion section of the endoscope main body, a branch member is disposed. The branch member is provided so that a first extended section and a second extended section are branched from each other and thereby first and second operating sections are separately arranged. Furthermore, the branch member has an opening as an inlet which guides an imaging module in a distal end of the observation optical system to a hard portion of the insertion section.
US08485963B2 Implantable devices for the treatment of incontinence and methods of using same
Implantable devices are designed to provide support to the bulbar urethral region of a patient experiencing incontinence. Surgical methods are utilized to implant the devices, and surgical tools are utilized with the surgical methods.
US08485962B2 Implantable sling for the treatment of incontinence and method of using the same
A method of treating urinary incontinence includes making an incision and exposing urethral tissue in a patient and employing a tool to place an implant into the incision. The method also includes coupling a first end of the implant to the tool and directing the tool and the first end of the implant through a first obturator foramen of the patient and following the same approach on a contralateral side of the patient thus suspending the implant between the first obturator foramen and the second obturator foramen of the patient. The method additionally includes elevating a urethra of the patient with a central portion of the implant, and securing the first end of the implant relative to a first descending ramus of the patient and securing the second end of the implant relative to a second descending ramus of the patient.
US08485960B2 Piezoelectric, micro-exercise pad apparatus and method
An apparatus and method for micro-exercise apply piezoelectric stress to cells of a bone mass by inducing voltages in the bone mass. Application of dynamic, electromagnetic fields passing through the conductive bone mass induce currents and voltages locally in and around cells or groups of cells. The cells respond to the combination of mechanical stress and strain by building themselves up as they would if they had been subjected to the stress and strain of conventional exercise. Thus, micro-exercise at a cellular level of the bone mass can be stimulated as if the stress and strain had been applied to the entire bone structure of which the smaller cellular portions are constituent parts. In combination with casts or splints, the sources of electromagnetic flux may be embedded in the frame or solid structure, the protective padding added for comfort, or both.
US08485959B2 Centrifugal separator and a liquid phase discharge port member
A centrifugal separator comprises a bowl rotating in use around an axis of rotation. The axis of rotation extends in a longitudinal direction, and a radial direction extends perpendicular to the longitudinal direction. A base plate provided at one longitudinal end of the bowl, said base plate having an internal and external side, an outlet opening being provided in the base plate. A casing is projecting at the outlet opening on the external side of said base plate, said casing comprising a casing side, a normal to said casing side extending at an acute angle relative to a circumferential direction of the bowl at said casing and a discharge opening is provided in said casing side. The discharge opening is radially outwardly limited by a weir with an overflow edge and said discharge opening extending radially inwardly to a position above a highest intended level of liquid in the bowl.
US08485947B2 Total body strengthening toning workstation and method of using same
A stand-alone exercise apparatus includes a seat to support a user in a position thereon, and upper and lower body exercising assemblies which are configured for activation either sequentially or simultaneously to permit the concurrent exercising movement of his or her upper body area and lower body leg muscles, respectively, without necessitating that the user stop exercising when switching from upper body exercises to lower body exercises. The lower body exercising assembly includes a lower frame assembly which is operable to provide resistance exercise to the user's leg muscles, and which includes a selectively reciprocally movable pedal, platform or bar which is coupled to a suitable resistance mechanism, and which is engagable by the user's feet and/or legs as they are moved together in unified movement to effect leg extensions or curls. The upper body exercising assembly includes one or more reciprocally movable frame members, hand pulleys or swing arms coupled to a resistance mechanism, and which are engagable by the user's hands and/or arms. The resistance mechanisms used to provide the selected resistance to the upper and lower exercising assemblies are operable independently from each other, and enable the user to select the degree of resistance to each of the upper and lower body exercising assemblies separately.
US08485946B2 Turn weight plate
Devices, apparatuses, systems and/or methods related to weight plates. Specifically, the disclosed devices, apparatuses, systems and/or methods relate to nested weight plates including a first weight plate increment and a second weight plate increment configured to receive the first weight plate increment. The nested weight plates may include a turning mechanism including a turning circle and/or a screw. The screw may be received by the first weight plate increment such that rotation of the turning circle engages and/or disengages the second weight plate increment. In this manner, a user may select to total weight desired.
US08485944B2 Contribution of energy to an intelligent electrical network through an exercise apparatus
Contribution of energy to an intelligent electrical network through an exercise apparatus is disclosed. In one aspect, an exercise apparatus includes a frame and a movable object coupled to the frame to generate an electrical energy when a mammal applies a force upon the movable object. In addition, the exercise apparatus includes an energy capture mechanism coupled with the movable object and the frame to harness the electrical energy from the movable object. The exercise apparatus also includes an energy transfer mechanism coupled with the movable object and the frame to transfer the electrical energy to an intelligent electrical network. The mammal described herein may be a human, a domesticated animal, a pack animal, and a beast of burden.
US08485940B2 Power control device
A power control device includes: an engine control unit and a transmission control unit provided so as to control power of the engine, and configured such that if an actual operating point, which is an operating point indicating a combination of actual revolution speed and torque of the engine, is located in a non-supercharging region and a final target operating point, which serves as a target operating point during acceleration, is located in a supercharging region, the revolution speed of the engine is increased until the actual operating point is shifted into the supercharging region, and the revolution speed of the engine is decreased after the actual operating point has entered the supercharging region, thereby shifting the actual operating point into the final target operating point when accelerating the vehicle.
US08485939B2 Method for controlling a drive train
A method of controlling a drive-train of a motor vehicle, which comprises an internal combustion engine with a driveshaft, an electric machine in driving connection with the driveshaft of the internal combustion engine, a semi-automatic transmission with an input shaft and a plurality of gears that can be engaged selectively, and an automated friction clutch arranged between the driveshaft of the internal combustion engine and the input shaft of the transmission, such that a gearshift of the transmission occurs in combination with suitable control of the internal combustion engine while the friction clutch is at least partially and/or briefly engaged. To speed up the shifting process and to attenuate torque and speed surges during the shifting process, the electric machine is operated briefly as a generator and/or as a motor.
US08485936B2 Planet shaft retention in planetary gear system
A planet shaft for supporting a planet gear has a supporting portion extending along a central axis and having a first outer diameter. A flange is formed at one end of the supporting portion, which has a smaller section formed about a portion of a circumference around the central axis, and an enlarged portion extending away from the central axis for a greater distance than the smaller portion. A hole to receive a lock member is formed in the enlarged portion. A planetary gear assembly including such a planet shaft is disclosed as is an air turbine starter including the planetary gear system. Further, a method of installing a planet gear and planet shaft is also disclosed and claimed.
US08485934B2 Multi-ratio transmission
A multi-ratio transmission comprising four planetary gearsets, eight rotary shafts and six shifting elements including first, second, third and fourth clutches and first and second brakes. The shafts either directly couple or selectively couple, via the shifting elements, the gearsets to each other or a housing of the transmission so as to implement nine forward gears and one reverse gear.
US08485929B2 Motor vehicle power train
A motor vehicle power train includes a main drive engine with an output shaft for driving the drive wheels of the motor vehicle, an electric motor which includes a rotor and a stator, also for driving the drive wheels of the motor vehicle, an automatic transmission, with a plurality of selectively settable drive connections, a transmission input shaft and a transmission output shaft, the rotor of the electric motor being disposed in a drive connection between the output shaft of the main drive engine and the transmission input shaft, and can be disengaged from the output shaft with a clutch, and at least one ancillary unit which can be driven by the main drive engine. The rotor of the electric motor includes an exterior drive having a gearing of friction surface which has a driving connection to the at least one ancillary unit.
US08485920B2 Metal wood golf club head
An improved golf club head is disclosed which comprises the positioning of secondary weights at such low, rearward and outward locations that it causes an alteration in the traditional look of the club head wherein each secondary weight has a portion of the weight that bulges outwards of the natural contour of the club head.
US08485919B2 Golf club head with composite weight port
A golf club head having a face component, a crown, and a composite sole or a composite body patch with one or more weight ports for receiving one or more weight inserts is disclosed herein. At least part of each of the weight ports is integrally formed in the composite sole or composite body patch, and each of the weight ports include a weight receiving region for receiving a weight and a screw receiving region for receiving a screw that secures the weight in the weight port.
US08485918B2 Golf club head with face insert
A golf club head with a face insert that is only partially connected to the body of the golf club head is disclosed herein. More specifically, the present invention discloses a golf club head with a face insert wherein the face insert is only connected to the body of the golf club head at specific engagement portions around the perimeter of the face insert while keeping the remainder of the perimeter unengaged. The golf club head disclosed in accordance with the present invention will allow for removal of excessive weight traditionally needed to connect the face insert to the body of the golf club head, therefore improving the performance of the golf club head.
US08485915B2 Variable length golf club shaft
A variable length shaft assembly comprising a shaft adapter, a grip support, and an engagement device is disclosed herein. The variable length shaft assembly of the present invention allows a golfer to quickly, semi-permanently, and inexpensively change the overall length of the shaft assembly, such that the shaft performs as desired and conforms to USGA rules. The variable length shaft assembly of the invention may further a travel limiter to prevent parts of the shaft assembly from disengaging from each other. Methods of adjusting the length of a golf club shaft without damaging any portion of the shaft are also disclosed herein.
US08485909B2 Torsional vibration damper and spindle
A torsional vibration damper for coupling two machine parts disposed coaxially to each other, in particular for coupling a cylindrical inner surface of a first machine part to a cylindrical outer surface of a second machine part, has a plurality of clamping bodies and a plurality of intermediate elements. The intermediate elements have higher elasticity than the clamping bodies and are disposed between adjoining clamping bodies.
US08485908B2 Flexible coupler
A flexible coupler for rotary power transmission may have several rubber bushings oriented in a circle about a coupler axis. The bushings may join two flanged components to form a single coupler. A single coupler may be used in applications where the axes of two transmission shafts are not parallel. Two couplers may be joined by a transmission shaft for applications where the axes of two transmission shafts may be parallel but offset from each other.
US08485893B2 Casino games
Apparatus and methods related to multi-player casino games are described. An electronic gaming device is provided that allows a live player to compete against a virtual player in a multi-player wager-based game. The electronic gaming device can comprise a multi-player game engine that does not distinguish between virtual players and live players. The electronic gaming device can be configured to simulate the decision making of a virtual player and associated behaviors of the virtual player during game play. In some instances, the simulated behaviors of the virtual player output at the electronic gaming device can be learned by a live player so that the live player can make better or more advantageous game play decisions. The simulated behaviors of the virtual player can be conveyed to the live player via visual images, such as simulated facial expressions of the virtual player.
US08485891B2 Wagering game with player banking of positive expectation situations
A method, apparatus, and computer readable storage to implement a disbursement of potential awards in a wagering game that have not been fully awarded yet. In a wagering game that comprises multiple states, a value of a favorable state relative to a prior state can be banked for later redemption by a player.
US08485889B2 Method, apparatus and article for random sequence generation and playing card distribution
A method, apparatus and article generates a pseudo-random playing card sequence and distributes playing cards according the pseudo-random playing card sequence. For example, the method, apparatus and article generates a pseudo-random playing card sequence and prints playing cards in order of the pseudo-random playing card sequence. Further, the method, apparatus and article generates a pseudo-random playing card sequence based on a house advantage. Yet further, the method, apparatus and article can generate a promotional message on one or more playing cards.
US08485867B2 Honing apparatus
An improved structure of a honing apparatus includes a body, a suction unit, a control unit, a driving unit, a connecting unit and a upper cap, wherein a base is formed at circumference of the body and a trough is formed in the middle of the base, and a sliding trough is formed at one side wall on the other side of the body and a first hone is formed at a top surface of the body. At center of one lateral surface of the suction unit has an extended pulling stick and an eccentric protruding portion is formed in the control unit, while the other lateral surface has an extended manipulating portion. The driving unit has a threaded stick that has a rotating button at one enlarged end. The connecting unit has a through opening at a closer end of a lateral surface and a threaded unit is inside the connecting unit and aligned with the through opening. A second hone is hingedly formed at a top surface of the connecting unit close to the other end. A bottom surface of the upper cap corresponding to the sliding trough has a recessed portion, and a hole is formed to enable the first hone to penetrate upward.
US08485866B2 Substrate holding apparatus, polishing apparatus, and polishing method
A substrate holding apparatus prevents a substrate from slipping out and allows the substrate to be polished stably. The substrate holding apparatus has a top ring body for holding and pressing a substrate against a polishing surface, and a retainer ring for pressing the polishing surface, the retainer ring being disposed on an outer circumferential portion of the top ring body. The retainer ring includes a first member made of a magnetic material and a second member having a magnet disposed on a surface thereof which is held in abutment against the first member.
US08485864B2 Double-side polishing apparatus and method for polishing both sides of wafer
The double-side polishing apparatus is capable of uniformly polishing a wafer and highly preventing an outer edge of the wafer from being damaged. The apparatus comprises: a lower polishing plate and an upper polishing plate for polishing both sides of the wafer; a carrier having a main body part, in which a through-hole for holding the wafer is formed. Edges of the through-hole in an upper face and a lower face of the carrier are coated with coating layers, which are composed of an abrasion-resistant material and which have a prescribed width and a prescribed thickness. A resin cushion ring, which has a prescribed width and whose thickness is equal to that of the main body part of the carrier, is provided to an inner circumferential face of the thorough-hole. The wafer is held in the resin cushion ring.
US08485857B1 Method of producing a spark gap for an electrode support using sacrificial material
A method of producing an electrode support for a spark plug is provided. The method includes attaching a chip to the electrode support. The chip includes a section of sacrificial material located between two sections of electrode material. The method includes substantially removing the section of sacrificial material from the chip to create a spark gap between the two sections of electrode material.
US08485847B2 Press-fit coupling joint for joining insulated conductors
A method for coupling an end of a first insulated conductor to an end of a second insulated conductor that includes placing a sleeve over the end of the first insulated conductor and the end of the second insulated conductor; filling an interior volume of the sleeve with electrically insulating material; and moving the end of the first insulated conductor and the end of the second insulated conductor towards the center of the sleeve. When the ends of the insulated conductors are moved together an end of a core of the first insulated conductor and an end of a core of the second insulated conductor are coupled inside a core coupling located inside the sleeve and the electrically insulating material is compressed between an end portion of an electrical insulator in the first insulated conductor and an end portion of an electrical insulator in the second insulated conductor.
US08485844B2 L-shaped connector
An L-shaped connector, which can waterproof simply and connect an L-shape terminal to an electric shield wire in miniaturized size so as to insulate and electromagnetic shield the L-shaped terminal, includes an L-shaped dividable insulation inner housing receiving an L-shaped terminal joined to the electric shield wire; an electric conductive shield shell covering a terminal receiving portion of the inner housing; an outer housing covering the shield shell; an electric conductive housing receiving a wire lead-out portion of the inner housing, and joining a flange of the shield shell and a flange of the outer housing to a flange of the electric conductive housing by screwing, and connecting a shield portion of the electric shield wire through a shield terminal to the shield shell; and a shield packing waterproofing between the flange of the shield shell and the flange of the electric conductive shell.
US08485842B2 Connector
A connector includes an electric cable, an electric connecting portion that includes a case body in a rectangular shape and a circuit board, and has, on the circuit board, a line connecting portion electrically connected to a line of the electric cable, and a cable fixing portion to which the electric cable is fixed, a flat-type connector case that has a housing space housing the electric connecting portion and the electric cable, an opening in which the case body is integrally mounted, and an extension hole from which the electric cable is extended into the housing space, and is fixed to an intermediate portion of the electric cable, and a slide member that is slidably disposed in the housing space, and includes, on one surface side, a cable bending shape defining portion that defines a bending shape of the electric cable which is housed in the housing space.
US08485841B2 Clamping spring for a spring-cage terminal block
A clamping spring for a spring-cage terminal includes a spring-steel band having a clamping arm, a supporting arm and a flexural joint joining the clamping arm and the supporting arm. The spring-steel band has a greater width in an area of the flexural joint than in an area of the clamping arm and the supporting arm.
US08485839B2 Modular interface communications with a storage cartridge
A serial interface connector and corresponding method electrically connects to a storage cartridge that has a housing enclosing a serial communications device. The serial interface connector has a first plurality of electrical contacts and a retainer. The retainer operably contactingly engages the housing to impart a bias that retains the electrical contacts of the serial interface connector seated in electrical connection with a respective second plurality of electrical contacts of the serial communications device.
US08485838B2 Lever-type connector with collective rubber stopper
A first housing (10) has a frame (11) with concave accommodation portions (20). A sub-connector (31) with female terminal fittings (33) is accommodated in the concave accommodation portions (20). A collective rubber stopper (36) is accommodated inside the concave accommodation portions (20) to seal a gap between a peripheral surface of an electric wire (34) pulled out of the sub-connector (31) and an inner peripheral surface of each concave accommodation portion (20). A first cam follower (19) is formed on an outer surface of the frame (11) and can engage an operation member (80). The frame (11) has an outer wall (12) defining an outer surface thereof where the first cam follower (19) is formed and an inner wall (18) separated from the outer wall part (12) via separated spaces (17) and constructing the inner peripheral surface of each concave accommodation portions (20).
US08485837B2 Electrical wet connector in downhole environment
An electrical connection for use in boreholes or other remote environment has first and second conductive members. The two conductive members are movable to form an electrical contact. Also provided is a means for urging dielectric fluid around the electrical contact formed by the first conductive member and second conductive member as the first and second conducting members are moved together.
US08485836B2 Connector with short-circuiting terminal
A connector has a first housing (10), a pair of first terminal fittings (50) accommodated in parallel with each other inside the first housing (10), a short-circuiting terminal (40) mounted inside the first housing (10) and short-circuiting a pair of the first terminal fittings (50), and a sub-housing (30) having insulating properties and holding the short-circuiting terminals (40). An accommodation chamber (17) formed inside the first housing (10) is open on an outer side surface of the first housing (10) as a mounting/removing opening (18). The sub-housing (30) is inserted into the accommodation chamber (17) in almost parallel with a direction in which a pair of the first terminal fittings (50) is arranged.
US08485835B2 Electrified suspended ceiling grid
A suspended ceiling grid tee of conventional cross-sectional shape having a plurality of generally planar parallel and orthogonal surfaces and at least two electrically isolated conductor strips attached to the planar areas of the tee surfaces extending along substantially the full length of the tee, a connector for supplying low voltage electrical power to or from the conductors, the connector having a configuration complementary to the cross-sectional shape of the grid tee and including at least two electrical contacts for energizing each of said conductor strips when said connector is positioned on said grid tee.
US08485830B1 Socket having symmetrically arranged first and second casings with interlocking arrangements to define a LED seat
An socket for light string is provided to include a pair of symmetrically arranged first and second casings mated together. Each of the first and second casings is featured with a side opening, and a first and second end channels, interlocking arrangements provided at internal wall thereof so as to securely interlock the first and second casings to configure the socket with a LED seat formed by the openings to host an LED, and passages for securely receiving conductive wires configured by the first and second channels. A partition is provided under the LED seat so as to insulatively isolated the conductive wires. Inner surfaces of the channels are provided with teeth to firmly hold the conductive wires. The socket is preferable for the use of configuring a light string.
US08485826B2 Portable terminal device having function of measuring mental fatigue and its measuring method
A portable terminal device (1) capable of easily evaluating mental fatigue comprises: an operation unit (4); an imaging unit for measuring ambient light (5); a display screen (2) or a light-emitting element (3) for presenting a flashing image or light while a flicker frequency of the flashing source is being monotonically changed from a start frequency to an ending frequency; and a recording unit for, when a user operates the operation unit (4) as the user perceives a flicker, recording the flicker frequency at the time point as a measured frequency, wherein: a first frequency datum, which is the measured frequency measured when the user is in a healthy condition, is associated with a first luminance datum, which is a measured ambient luminance, and the associated datum is stored in the recording unit, a proportion of decrease of a second frequency datum, which is the measured frequency measured when the user is not in a healthy condition, from the first frequency datum recorded in the recording unit and associated with the first luminance datum which has the same or similar order of magnitude to a second luminance datum, which is a measured ambient luminance, is calculated to evaluate a degree of fatigue of the user.
US08485821B2 Tooth whitening dental tray and method of use
A dental tray with a hydrophobic tooth whitening formulation where the tooth whitening formulation is substantially non-water soluble, and a method of using this dental tray to whiten the teeth. The tooth whitening formulation is primarily comprised of a hydrophobic polymer and a peroxide or a peroxide yielding compound. Preferably the hydrophobic polymer is the condensation product of a silicone resin and an organosiloxane. The dental tray is formed to encompass the front and the rear surfaces of the teeth. The dental tray is comprised of a thermoplastic or thermoset polymer. The teeth whitening formulation is placed into the dental tray and the tray placed against the teeth to be whitened. This is for a sufficient period of time to at least partially whiten teeth. This can be a period of time from about 0.5 hour to 2 hours or more. The substantially non-aqueous tooth whitening formulation is effective over a longer period of time since it is not significantly diluted or removed from the dental tray during the treatment time.
US08485818B2 Fluid controller
A fluid conditioning system is adapted to condition the fluid used in medical and dental cutting, irrigating, evacuating, cleaning, and drilling operations. The fluid may be conditioned by adding flavors, antiseptics and/or tooth whitening agents such as peroxide, medications, and pigments. In addition to the direct benefits obtained from introduction of these agents, the laser cutting properties may be varied from the selective introduction of the various agents.
US08485815B2 Overhung rotary tube furnace
A rotary tube furnace (1) comprising an insulated heating chamber (4), the insulated heating chamber having a product discharge outlet (21) and a process tube inlet (39), a heating element (14) operatively arranged to selectively heat the heating chamber, a generally horizontally extending process tube (2) supported for rotation relative to the heating chamber, the process tube having a first portion (36) generally arranged outside of the heating chamber and a cantilevered second portion (37) extending from the first portion into the heating chamber and terminating at a discharge end (38) within the heating chamber, a feed mechanism (40) configured and arranged to feed product into the process tube, and a bearing assembly operating between a support frame (34) and the first portion of the process tube and configured and arranged to support the process tube and transmit rotational torque to the process tube.
US08485811B2 Fine structure formation apparatus
A fine structure formation apparatus includes a preheating heater to heat up the surface of belt-like mold alone, right before contacting the belt-like mold to heating and pressurizing rollers, the temperature of the surface of the belt-like mold is made equal to that of the heating and pressurizing rollers, enabling to reliably obtain a predetermined temperature, and cooling rollers or a cooling blower are arranged right after the heating and pressurizing rollers, enabling cooling by a forced cooling and pressure holding, and to transfer a pattern.
US08485808B2 Apparatus for producing three-dimensional shaped product
An apparatus for producing a three-dimensional shaped product in which a powder and a shaped article are loaded on a base plate, a frame body is installed upright on a table, a support projecting from the frame body and/or a restraining support provided at the top of the frame body are used to support the base plate, the base plate is supported by arranging the center of gravity of the base plate so as to be present, two or more recesses provided at the back of the base plate are fitted into two or more extension supports which cross each other and/or restraining supports, and projected parts provided on supports and/or wall parts of the frame body are contacted with horizontally surrounding parts of the base plate on both sides in the longitudinal direction of at least one recess among the recesses, thereby attaining the above object.
US08485807B2 Device and method for thermoforming a sheet
The device for thermoforming a sheet has two molds. The first mold includes a movable plug support plate and heated plugs projecting from the plug support plate, which plugs are spaced a predetermined distance apart. A plurality of induction coils is arranged stationary in an area of the device adjacent to the plug support plate, and the plug support plate has an induction element of inductively heatable material.
US08485803B2 Scroll compressor comprising oil separating driving shaft
The present invention relates to a scroll compressor, with an oil-separating drive shaft, that comprises a housing a fixed scroll which is installed inside the housing, a orbiting scroll which orbits around the fixed scroll, and a drive shaft which drives the orbiting scroll. In the orbiting scroll, a discharge hole is formed. A discharge path is formed along the longitudinal direction of the drive shaft so that discharged coolant from the discharge hole flows therethrough. At least, a part of the discharge path is inclined forward from the rotary axis to the exterior. A lubrication hole is formed in the drive shaft that penetrates from the discharge path to the outer surface of the drive shaft.
US08485801B2 Poppet valve assembly
A novel valve assembly is provided. In one embodiment, the valve assembly includes a seat plate having a plurality of fluid conduits. The valve assembly may also include a plurality of poppet assemblies. In some embodiments, a poppet assembly of such a plurality includes at least one fluid port and a housing configured to be coupled to the seat plate to facilitate flow of a fluid through a respective fluid conduit via the at least one fluid port of the respective poppet assembly. Other devices, systems, and methods related to poppet assemblies are also disclosed.
US08485800B2 System and method for pumping fluid using a pump cassette
A system and method for pumping fluid using a pump cassette. The system includes a control assembly for operating the pump cassette. A force assembly having a movable member is capable of applying force to the pump cassette to press the pump cassette against the control assembly. The movable member may be an expandable member, such as a bladder.
US08485799B2 Vertical flow cage and method of use
The present invention is centralizing vertical flow cage attachable to a subsurface pump in a downhole recovery application, and method of use. In one embodiment, the vertical flow cage is defined as comprising a hollowed, centralizing cone portion having at least one spiral vein formed in the cone's surface. In another embodiment, the centralizing cone includes a ledge having at least one discharge hole disposed thereon, with each discharge hole being selectively located above each vein. Each discharge hole is formed through the centralizing cone so that each hole formed is in fluid communication with the hollow interior portion of the centralizing cone. In this regard, during the pump process upstroke, any fluid below and outside of the centralizing cone will be forced vertically upwards through each vein. This fluid flow will be assisted by the flow of fluid through each hole, as any fluid within the hollow portion will flow upward and through each hole, thereby providing a synergistic vertical fluid flow effect.
US08485797B2 External oil expansion chamber for seabed boosting ESP equipment
An expansion chamber to serve ESP equipment installed on the seabed located in either a caisson or a conduit on a skid. The expansion chamber provides an external reservoir for expansion and contraction of motor oil in the ESP equipment. During operation of an ESP, the heat generated in the motor raises the temperature of the motor oil, causing it to expand. The expansion chamber is connected to the ESP equipment via oil lines that allow oil to expand into the expansion chamber when the temperature of the motor oil increases. The expansion chamber has a movable barrier therein that defines primary and secondary chamber. Oil communicates with the primary chamber. Formation fluid within the conduit surrounding the motor communicates with the secondary chamber.
US08485796B2 Booster water spraying system
A garden hose spray system includes a water pump and a controller with a switch for engaging and disengaging the pump. The pump is used for boosting a water flow through the system. The controller is in communication with the pump, and directs the switch to engage the pump when the water flow exceeds a predetermined, non-zero threshold flow rate. In certain embodiments, the system further includes a variable outlet. The variable outlet is operable at a first flow setting for a flow rate greater than the threshold and a second flow setting for a non-zero flow rate less than the threshold.
US08485794B2 Reciprocating compressor with rotary valve
According to the present invention, a reciprocating compressor with a rotary valve comprises a cylinder block with plural cylinder bore, a drive shaft which is supported and permitted to rotate in relation to the cylinder block, a piston which is housed in the cylinder bore and allowed to reciprocate therein, a power transmitting unit which connects the piston and drive shaft, a rear housing wherein an intake chamber and exhaust chamber are formed, and a rotary valve which rotates with the drive shaft and is installed in the inner surface of a coupling hole formed in the cylinder block and permitted to slide and rotate therein. In the inner circumference of the cylinder block, connection holes are respectively connected to the cylinder bore. A bypass unit is included between the coupling hole and rotary valve and bypasses the refrigerant remaining in the connection hole of one cylinder bore during the compressive stroke of the piston, then discharges it through the connection hole of another cylinder bore.
US08485793B1 Chip scale vacuum pump
A chip scale structure fabricated from known MEMS processes is provided including a pump actuator, a pump volume, pump membrane, a valve membrane, a valve aperture, and a valve actuator. The pump actuator may include a piezoelectric or piezoceramic disk. The valve actuator may be a piezoelectric or piezoceramic disk. A manifold plate with a valve aperture is disposed between the pump membrane and the valve membrane. One or more vacuum chambers are provided along a vacuum flow path or conduit in communication with the one or more vacuum chambers. The flow path comprises an inlet port and an outlet port where the inlet port is in communication with the separately provided vacuum environment. The outlet port is in commemoration with an external environment (e.g. non or lower-vacuum environment) for exhausting gases that are pulled from the separately provided vacuum environment to a separate location.
US08485790B2 Fuel supply unit for a motor vehicle
A fuel-supply unit for a motor vehicle has a fuel container (2) that has several chambers (6, 7). The unit has a transfer pump (5) that is located inside the fuel container (2) for exclusively supplying ejector pumps (9, 10), which are positioned in the chambers (6, 7), with fuel as the pumping fluid. A primary fuel pump (4) that is located outside the fuel container (2) supplies an internal combustion engine (1) of the motor vehicle with fuel. The transfer pump (5) is operated discontinuously to prevent unnecessary power consumption.
US08485787B2 Turbine airfoil fabricated from tapered extrusions
An airfoil (30) and fabrication process for turbine blades with cooling channels (26). Tapered tubes (32A-32D) are bonded together in a parallel sequence, forming a leading edge (21), a trailing edge (22), and pressure and suction side walls (23, 24) connected by internal ribs (25). The tapered tubes may be extruded without camber to simplify the extrusion process, then bonded along matching surfaces (34), forming a non-cambered airfoil (28), which may be cambered in a hot forming process and cut (48) to length. The tubes may have tapered walls that are thinner at the blade tip (T1) than at the base (T2), reducing mass. A cap (50) may be attached to the blade tip. A mounting lug (58) may be forged (60) on the airfoil base and then machined, completing the blade for mounting in a turbine rotor disk.
US08485786B2 Reinforced blade for wind turbine
The present invention relates to a reinforced blade for a wind turbine, and in particular to a wind turbine blade comprising a shell having a section with an aerodynamic profile, and at least one internal reinforcing floor connected inside the shell and extending substantially along the profile chord in order to increase the strength of the blade and to prevent or reduce deformations of the surface of the blade caused by edgewise and flapwise loading of the blade structure.
US08485779B2 Turbocharger
A sealing device for prevention of exhaust gas in a scroll passage from leaking via a gap to a turbine impeller is arranged upstream, in a travel direction of the exhaust gas, of through-holes via which the vane shafts extend through a rear exhaust introduction wall, whereby pressure in a gap communicating with the through-holes of the rear wall is kept lower than pressure in an exhaust nozzle so as to displace nozzle vanes to the rear wall.
US08485773B2 Device for moving large containers
Devices and methods of using such devices to move containers are disclosed herein. A device may include a first piece with a wheel adjacent one end and a second piece attached to the first piece at a pivotal connection. The second piece may include a lift portion on one side of the pivotal connection and a handle on an opposite side of the pivotal connection. The handle may be adapted to be pivoted about an axis of the pivotal connection to cause the lift portion to lift a portion of the container.