[0001] 本
发明涉及了一种纳米孔生物人工骨组织复合物的工艺工程，针对与宿主骨组织结合时的人体免疫反应的
预防，同时减少了其整合的周期。因为其瞬时硬化性质和可瞬时整合于人体任一部份骨架内，所以组合物可让任何可植入装置实
时移植到该生物复合物中。该纳米多孔生物
复合材料第一成分为羟基
磷灰石(HA)，或/和α-或β-
磷酸三
钙(a-或β-TCP)或/和由组合HA和TCP而生成的双相磷酸钙(BCP)，或/和颗粒不超过99nm的
硫酸钙(CaSO4)。下一成份是聚己内酯(PCL)或颗粒也不超过99nm的聚乳酸(PLA)。其他成分为：佳乐施或是任何佳乐施溶液或凝胶，之后加入一定量的
水以形成本复合物的凝胶或是可注射溶液。之后，任何含有结缔胶原组织(f.ex cagut等)组成的任何物质。再之后，本发明提供了一种重组人体血管内皮生长因子A165(rhVEGF-A165)，其剂量是低于人体血管内皮细胞(HUVEC)增值之剂量依赖性的最终化合物的1-3ng ml。然后，任何作为分子配体种类的
丙烯酸酯类(氰基丙烯酸酯类或磺内酯类化合物等)，在当所有该化合物的硬化和最终过程是经过一段小于60秒的时间、且
频率介于24到32Khz
超声波而立即获取。不同成分的比例是可变的，并且可以分别对应
治疗的骨的类型和形式作出调适。在任何情况下，化合物的第一成分(HA或a-或β-TCP等)与PCL或/和PLA的比例为所得中间体化合物的58％-66％。对于0.6ml的复合物而言，丙烯酸酯(氰基丙烯酸酯或磺内酯等)不少于2滴，且不超过6滴。使用三维绘图
软件(3D CAD)建模和
压制成型，可以利用此复合物来制成制作任何骨骼(人类或动物)。β-TCP可以用生物可降解的Fe-Mg金属相或Fe-Ag纳米复合材料来增强。在任何种类的接合部位中，将会加入相关的涂层(例如，
钛亚
硝酸盐，也被称为TiNite(TiN))涂层或类钻石
碳(DLC)涂层等。在脊椎处则可将可生物兼容性磷脂加入该生物复合物中。
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