专利汇可以提供MAGNETIC RESONANCE IMAGING SYSTEMS FOR PARALLEL TRANSMIT, RECEIVE AND SHIM AND METHODS OF USE THEREOF专利检索,专利查询,专利分析的服务。并且MRI systems with a new concept and hardware modality configured for parallel transmit, receive, and shim to address B0 and B1 inhomogeneity, both of which increase with field strength. This invention benefits from a number of advantages over existing technologies: it can save valuable space within the MRI magnet bore, largely reduce the manufacturing cost of MRI scanners, and avoid the electromagnetic interference issue associated with existing technologies.,下面是MAGNETIC RESONANCE IMAGING SYSTEMS FOR PARALLEL TRANSMIT, RECEIVE AND SHIM AND METHODS OF USE THEREOF专利的具体信息内容。
This application claims priority to and the benefit of U.S. Provisional Application Ser. No. 61/665,517, filed Jun. 28, 2012, the contents of which are hereby incorporated by reference as if recited in full herein.
This invention was made with government support under Grant No. R01 EB 009483 from the National Institutes of Health. The government has certain rights in the invention.
This invention relates to Magnetic Resonance Imaging.
In magnetic resonance imaging (MRI), an RF coil with a set of radiofrequency (RF) coils (coil array) or transverse electromagnetic (TEM) coil elements can be used to transmit and receive the signal in parallel through multiple channels. Such coils may further be used in combination with special acquisition and reconstruction techniques based on parallel transmit and/or receive to improve the homogeneity of the RF magnetic field B1 (RF shimming or B1 shimming) or to reduce the scan time (parallel imaging), respectively. See, e.g., U.S. Pat. Nos. 7,598,739 and 7,800,368, the contents of which are hereby incorporated by reference as if recited in full herein. In addition, a separate set of coils (shim coils) can be used to generate a non-uniform magnetic field designed to compensate for any inhomogeneities of the static magnetic field B0 (active B0 shimming). See, Juchem C, Brown P B, Nixon T W, McIntyre S, Boer V O, Rothman D L, de Graaf R A. Dynamic multi-coil shimming of the human brain at 7 T. J Magn Reson 2011; 212:280-288; and Pan et al., Role of very high order and degree B0 shimming for spectroscopic imaging of the human brain at 7 Tesla, Mag. Res. In Med. 2011 Dec. 28, doi:10.1002/mrm.24122, the contents of which are hereby incorporated by reference as if recited in full herein.
The present disclosure provides a new concept and hardware modality for integrated parallel transmit, receive, and shimming. The concept can be used to implement parallel transmit/receive (which can include B1 shimming and/or parallel imaging capabilities) and B0 shimming by employing the same set of localized coil elements or TEM coil elements, with each coil or TEM coil element working in both an RF mode (for transmit/receive) and a direct current (DC) mode (for B0 shimming) simultaneously. With an appropriate coil design, both an RF and a DC current can flow in the same coil element simultaneously but independently without electromagnetic interference between the two modes.
Embodiments of the invention can be used when the same RF coil array is used for parallel transmit and receive, and also when two or more separate coil arrays are used. In the latter case, the B0 shimming capability can be integrated into each coil array and at least some, typically all, coil elements from both arrays can be used together for B0 shimming, resulting in a large number of degrees of freedom.
It is noted that aspects of the invention described with respect to one embodiment, may be incorporated in a different embodiment although not specifically described relative thereto. That is, all embodiments and/or features of any embodiment can be combined in any way and/or combination. These and other objects and/or aspects of the present invention are explained in detail in the specification set forth below.
The foregoing and other objects and aspects of the present invention are explained in detail herein.
The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawings will be provided by the Office upon request and payment of the necessary fee.
FIGS. 6A and 6Bb are measured B0 maps and
For the purposes of promoting an understanding of the principles of the present disclosure, reference will now be made to preferred embodiments and specific language will be used to describe the same. It will nevertheless be understood that no limitation of the scope of the disclosure is thereby intended, such alteration and further modifications of the disclosure as illustrated herein, being contemplated as would normally occur to one skilled in the art to which the disclosure relates.
Articles “a” and “an” are used herein to refer to one or to more than one (i.e. at least one) of the grammatical object of the article. By way of example, “an element” means at least one element and can include more than one element.
Unless otherwise defined, all technical terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs.
In magnetic resonance imaging (MRI), a set of radiofrequency (RF) coils can be used to transmit and receive the signal in parallel through multiple channels. Such coils may further be used in combination with special acquisition and reconstruction techniques based on parallel transmit and/or receive to improve the homogeneity of the RF magnetic field B1 (RF shimming or B1 shimming) or to reduce the scan time (parallel imaging), respectively. In addition, a separate set of coils can be used to generate a non-uniform magnetic field designed to compensate for any inhomogeneities of the static magnetic field B0 (active B0 shimming).
Thus, existing technologies use one set of RF coils for parallel transmit/receive and a separate set of shim coils for B0 shimming. Embodiments of the present invention are directed to the integration of parallel transmit/receive and B0 shimming into the same set of coils. This provides a number of advantages over existing technologies. First, by eliminating the need to use separate local shim coils, which otherwise need to be placed in the proximity of the imaging object to achieve an effective high-order shimming, it can save valuable space within the MRI magnet bore, while still providing an optimized localized B0 shimming. Second, by simplifying the scanner design and/or reducing the size of the magnet bore without any sacrifice in performance, it can largely reduce the manufacturing cost of MRI scanners. Third, in some embodiments, the use of a single set of coils for both transmit/receive and B0 shimming, can avoid the electromagnetic interference issue between the outer RF coil array and the inner shim coil array (RF shielding) associated with existing technologies, which currently requires a large gap to be kept open in the middle of the shim coil array for the RF signal to go through, at the expense of the shimming performance, See, Juchem et al., supra., the contents of which are hereby incorporated by reference as if recited in full herein. Finally, this invention may be particularly useful for ultra-high field MRI (i.e., 7 Tesla and above), as it can address B0 and B1, inhomogeneity, both of which increase with field strength.
Two coil prototypes were designed and built based on a single-loop RF coil and a figure-8 loop RF coil. The original (prior art) circuit of the figure-8 coil is shown in
As shown in
With a parallel LC Circuit 26, (inductor 20 and capacitor 27), the figure-8 coil 10 becomes a dual-tuned RF coil with a high resonance frequency and a low resonance frequency. See, e.g., Ha et al., A PIN diode controlled dual-tuned MRI RF coil and phased array for multi-nuclear imaging, Phys. Med. Biol. 55 (2010), 2589-2600, the contents of which are hereby incorporated by reference as if recited in full herein.
In some embodiments, the inductor L2 20 can be chosen to be 10 times larger than the original inductance of the figure-8 coil, resulting in a low resonance frequency of 28 MHz and a high resonance frequency of 131 MHz, which is close to the original resonance frequency of 128 MHz (for a field strength of 3 Tesla) and makes it easy to tune and match the circuit. A similar design can also be applied to other types of coils.
In some embodiments, L2 20 is 2.6 pH. A high-power resistor, e.g., 8 ohm, can be inserted in the DC loop 10c since the coil resistance is only 0.06 ohm. In the prototype, a fuse with a 1 A maximum current was also inserted in the DC loop.
A full implementation of embodiments of the invention can include dedicated MRI hardware and software. In particular, a coil array 10A with multiple coils 10 should be used to provide the best results. To achieve an effective B0 shimming, the type, geometry, and location of each coil should be optimized and the amplitude and timing of the DC current in each coil should be individually adjusted. See, e.g., Juchem C, Brown P B, Nixon T W, McIntyre S, Boer V O, Rothman D L, de Graaf R A. Dynamic multi-coil shimming of the human brain at 7 T. J Magn Reson 2011; 212:280-288; and Pan et al., Role of very high order and degree B0 shimming for spectroscopic imaging of the human brain at 7 Tesla, Mag. Res. In Med. 2011 Dec. 28, doi:10.1002/mrm.24122, the contents of which are hereby incorporated by reference as if recited in full herein.
If available, the spherical harmonic shim coils integrated in the MRI scanner can further be used as additional degrees of freedom for B0 shimming. To achieve an effective B1 shimming, the amplitude, phase, timing, and frequency characteristics of the RF current in each coil element should also be independently adjusted. See, e.g., U.S. Pat. Nos. 7,598,739 and 7,800,368, the contents of which are hereby incorporated by reference as if recited in full herein
The commercial design involving both DC and RF aspects of the RF coil array can be considered together in order to optimize the B0 and B1 fields and/or to address a specific imaging problem.
Embodiments of the invention will be disused further below with reference to the following non-limiting examples.
Goal: Experiment 1 was performed to demonstrate that both the RF mode and DC mode of the modified figure-8 coil can be used simultaneously for transmit/receive and for generating an additional non-uniform B0 field, respectively.
Methods: Coronal images of a spherical water phantom were acquired on a GE 3T MRI scanner with a gradient-echo single-shot echo-planar imaging (EPI) sequence and the following parameters: repetition time (TR)=2 s, echo time (TE)=31 or 32 ms, flip angle=60°, field-of-view (FOV)=15×15 cm, matrix size=64×64, slice thickness=4 mm, and frequency direction=right/left (R/L). The coil was positioned in the coronal plane on top of the phantom with the two halves of the figure-8 in the R/L direction. B0 maps were computed from the phase images acquired at both TEs. CM and Cf were both adjustable capacitors with a range of 0-10 pf and the two capacitors were about 12 pf.
Results:
Conclusion: These results demonstrate that both the RF and DC modes of the modified figure-8 coil can work simultaneously.
Goal: Experiment 2 was performed to measure the B0 field generated by the DC mode of the modified single-loop and figure-8 coils. These B0 maps will be used in subsequent experiments to determine the optimal DC currents to be applied in each coil for B0 shimming.
Methods: Coronal 80 maps of a water phantom were acquired with a gradient-echo sequence and TR=1 s. TE=4.7 or 5.7 ms, flip angle=60°, FOV=22.5×22.5 cm, matrix size=128×128, and slice thickness=4 mm. The coils were positioned in a coronal plane on top of the phantom and a DC current of 130 mA was applied in one coil at a time. High-order shimming was first performed (without DC current) to obtain a uniform B0 field. In addition, B0 maps were also numerically simulated by using the Biot-Savart law for a single-loop coil and a figure-8 coil with an identical geometry and orientation as in the experiments.
Results and discussion:
Goal: Experiment 3 was performed to demonstrate that the DC mode of the modified figure-8 coil can actually be used for B0 shimming, i.e., to reduce the B0 inhomogeneity and improve the image quality.
Methods: Coronal images of a square water phantom containing a grid were acquired with a spin-echo single-shot EPI sequence and TR=2 s, TE=60 ms, FOV=20×20 cm, matrix size=128×128, slice thickness=4 mm, and frequency direction=R/L. The coil was positioned as in Experiment 2. High-order shimming was first performed (without DC current) to obtain a uniform B0 field.
Results:
Conclusion: These results demonstrate that the modified figure-8 coil can be used for simultaneous transmit, receive, and B0 shimming. Although there are still some residual distortions because this proof-of-concept experiment was performed with only one coil, which offers a relatively limited flexibility for shimming, a more effective shimming can be achieved by using multiple coils, as shown in Experiment 4.
Goal: Experiment 4 was performed to demonstrate that the modified single-loop and figure-8 coils can be used simultaneously, each with an RF and a DC mode, for parallel transmit, receive, and B0 shimming.
Methods: This experiment was identical to Experiment 3, except that the single-loop coil was added directly underneath the figure-8 coil. The DC loops of both coils were connected in parallel to the DC power supply. EPI images were acquired as in Experiment 3, but with FOV=22.5×22.5 cm and matrix size=192×192. B0 maps were acquired as in Experiment 2, Since our scanner does not have parallel transmit capability, the data were acquired sequentially by exciting only one coil at a time. The EPI images from both coils were combined by using the square root of the sum of squares, while the B0 maps from both coils were averaged.
Results:
Conclusion: These results demonstrate that the modified single-loop and figure-8 coils can be used for simultaneous parallel transmit, receive, and B0 shimming.
Goal: Experiment 5 was performed to demonstrate that the DC current in each coil can be individually adjusted, thereby introducing an additional degree of freedom to improve the B0 shimming.
Methods: This experiment was identical to Experiment 4, except that the relative ratio of the DC currents in both coils was adjusted by inserting resistors with different values into the two DC loops. Furthermore, EPI images were also acquired with frequency direction=S/1 in addition to R/L.
Results:
Conclusion: These results demonstrate that the DC current in each coil can be individually optimized to improve the B0 shimming.
Any patents or publications mentioned in this specification are indicative of the levels of those skilled in the art to which the invention pertains. These patents and publications are herein incorporated by reference to the same extent as if each individual publication was specifically and individually indicated to be incorporated by reference. In case of conflict, the present specification, including definitions, will control.
One skilled in the art will readily appreciate that the present invention is well adapted to carry out the objects and obtain the ends and advantages mentioned, as well as those inherent therein. The present disclosure described herein are presently representative of preferred embodiments, are exemplary, and are not intended as limitations on the scope of the invention. Changes therein and other uses will occur to those skilled in the art which are encompassed within the spirit of the invention as defined by the scope of the claims.
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