专利汇可以提供Micro-sensor for sensing chemical substance专利检索,专利查询,专利分析的服务。并且The invention discloses a micro-sensor for sensing a chemical substance. The micro-sensor according to the invention includes a substrate, a micro-cantilever, an electrode structure, and a measuring device. The micro-cantilever is formed on the substrate and has a capturing surface for capturing chemical substances. The electrode structure is for supplying an electrical field. The electrical field is disposed so as to assist the capturing surface in capturing chemical substances. The measuring device, coupled to the micro-cantilever, is for measuring a variation on a mechanical property of the micro-cantilever induced by the captured chemical substance and interpreting the variation on the mechanical property of the micro-cantilever into information relative to the chemical substance.,下面是Micro-sensor for sensing chemical substance专利的具体信息内容。
What is claimed is:
1. Field of the Invention
The present invention relates to a micro-sensor and, more particularly, to a micro-sensor for sensing a chemical substance.
2. Description of the Prior Art
Due to stepping into the generation of advanced-age and uneven medical resource allocation, bio-chips have caused a great attention in all industries; as a result, educational institutes or industrial circles have put a large amount of fund and manpower into exploration and research.
In bio-sensing systems, many bio-sensing techniques have been developed maturely, which can systematically classify bio-sensing systems by means of various transducers. However, in the bio-sensing systems, an electron-type or a contact-type sensing system, e.g. a scanning probe microscopy or a scanning tunneling microscopy, has the drawbacks of disturbing reaction processes among organisms and possibly ruining living organisms on the bio-chips. Besides, conventional detection systems generally have the problems of high cost of purchase and maintenance, large-volume, low sensitivity, long measurement time, and great consumption of samples.
A micro-cantilever biosensor has the advantages of fluorescent labels-free, high sensitivity, low-cost fabrication, and a large amount of potential parallel detection. The micro-cantilever biosensor has been under a certain development for miniatures. The micro-cantilever of a micro-cantilever biosensor can be bended by a surface stress when a molecule film is produced. Alternatively, a mass change on the micro-cantilever can be measured by a resonance way.
In recent years, the research and development of the micro-cantilever biosensor can be divided into the surface stress induced by the molecule film, a hybrid reaction of DNA, a mutual reaction between protein-based antigen-antibody and detections of drugs and metal ions.
To fabricate a micro-cantilever biosensor, it is first to immobilize a probing protein on the micro-cantilever, then an analyte reaction is measured by use of the recognition of the probing protein and bio-molecules. However, in the step of immobilizing the probing protein on the micro-cantilever, a large amount of probing protein is often consumed to increase the cost of fabricating a bio-chip. Moreover, the consumption of probing protein usually costs the most in the manufacture cost of the bio-chip.
To solve the aforementioned problem, the main scope of the invention is to provide a micro-sensor for sensing a chemical substance.
One scope of the invention is to provide a micro-sensor for sensing a chemical substance.
According to an embodiment of the invention, the micro-sensor includes a substrate, a micro-cantilever, an electrode structure, and a measuring device.
The micro-cantilever is formed on the substrate and has a capturing surface for capturing chemical substances. The electrode structure is for supplying an electrical field. The electrical field is disposed so as to assist the capturing surface in capturing chemical substances. The measuring device is coupled to the micro-cantilever. The measuring device is for measuring a variation on a mechanical property of the micro-cantilever induced by the captured chemical substance and interpreting the variation on the mechanical property of the micro-cantilever into information relative to the chemical substance.
Compared to the prior art, with the electrical field provided by the electrode structure, the micro-sensor according to the invention can not only increase the immobilization efficiency of probing proteins on the capturing surface of the micro-cantilever but also reduce the consumption of biochemical samples.
The advantage and spirit of the invention may be understood by the following recitations together with the appended drawings.
Please refer to
In practical applications, the chemical substance is a metal, a polymer, a biochemical molecule, or a micro-biochemical structure.
As shown in
In one embodiment, the substrate 10 can be formed of silicon, and the micro-cantilever 12 can be formed of Si3N4 or SiO2, but not limited therein. Besides, in one embodiment, the micro-cantilever 12 structure can exhibit V-shaped.
The micro-cantilever 12 is formed on the substrate 10 and has a capturing surface 120 for capturing chemical substances.
In one embodiment, if the analyte is a chemical molecule, the capturing surface 120 can be covered with a chemical sensing film. The chemical sensing film can serve as an interface for bonding the chemical molecule and the micro-sensor 1, or serve as a reaction surface directly reacting with the analyte.
In one embodiment, if the analyte is a bio-molecule or a micro-biochemical structure, the capturing surface 120 can be covered with a bio-material sensing film. Therefore, an immobilization reaction occurs only between the bio-material sensing film and a selective bio-molecule or a micro-biochemical structure.
The electrode structure 14 is for supplying an electrical field. Bye use of the charged particles (e.g. positive or negative electric charge), the electrical field is disposed so as to assist the capturing surface 120 in capturing chemical substances.
In one embodiment, if the electrical field is a DC electrical field, the DC electrical field can assist the capturing surface 120 in capturing chemical substances. Further, the electrical field can be converted from the DC electrical field to an AC electrical field, and the AC electrical field can assist the chemical substance in escaping from the capturing surface 120. Therefore, the DC electrical field and the AC electrical field can enhance the efficiency of repeated sensing of the chemical substance.
In practical applications, the electrode structure 14 can include a first electrode 140 formed on the capturing surface 120 of the micro-cantilever 12, and a second electrode 142 formed on the substrate 10. In one embodiment, the first electrode 140 can be formed of gold, and the second electrode 142 can be formed of nickel, but not limited therein.
The measuring device is coupled to the micro-cantilever 12. The measuring device is for measuring a variation on a mechanical property of the micro-cantilever 12 induced by the captured chemical substance and interpreting the variation on the mechanical property of the micro-cantilever 12 into information relative to the chemical substance.
Please refer to
As shown in
Please refer to
As shown in
In practical applications, the casing 20 can be formed of a glass, a polymer or a semiconductor material. In one embodiment, the casing 20 can be formed of polydimethylsiloxane (PDMS).
Please refer to
As shown in
Compared to the prior art, with the electrical field provided by the electrode structure, the micro-sensor according to the invention can not only increase the immobilization efficiency of probing proteins on the capturing surface of the micro-cantilever but also reduce the consumption of biochemical samples.
With the example and explanations above, the features and spirits of the invention will be hopefully well described. Those skilled in the art will readily observe that numerous modifications and alterations of the device may be made while retaining the teaching of the invention. Accordingly, the above disclosure should be construed as limited only by the metes and bounds of the appended claims.
标题 | 发布/更新时间 | 阅读量 |
---|---|---|
一种斜拉桥转体过程中的智能纠偏装置及方法 | 2020-05-15 | 2 |
一种装配式混凝土框架梁柱的连接节点 | 2020-07-14 | 1 |
一种带悬挂小车和带扇齿轮传动的悬臂起重机 | 2020-09-18 | 1 |
基于FDCA的聚酯 | 2021-03-16 | 1 |
微电子机械悬臂梁开关式微波功率耦合器及其制备方法 | 2021-07-28 | 1 |
大口径凸非球面两轴拼接测量装置 | 2022-05-23 | 1 |
一种温差、振动复合型压电俘能电池 | 2020-09-28 | 1 |
Acceleration sensor | 2023-06-30 | 0 |
支撑件及包装组件 | 2020-12-23 | 1 |
MICROFLUIDICS APPARATUS AND METHODS OF USE THEREFOR | 2022-12-03 | 0 |
高效检索全球专利专利汇是专利免费检索,专利查询,专利分析-国家发明专利查询检索分析平台,是提供专利分析,专利查询,专利检索等数据服务功能的知识产权数据服务商。
我们的产品包含105个国家的1.26亿组数据,免费查、免费专利分析。
专利汇分析报告产品可以对行业情报数据进行梳理分析,涉及维度包括行业专利基本状况分析、地域分析、技术分析、发明人分析、申请人分析、专利权人分析、失效分析、核心专利分析、法律分析、研发重点分析、企业专利处境分析、技术处境分析、专利寿命分析、企业定位分析、引证分析等超过60个分析角度,系统通过AI智能系统对图表进行解读,只需1分钟,一键生成行业专利分析报告。