Preparation of 3-hydroxy-3-methyl-phthalide or its nuclear substitution product
专利汇可以提供Preparation of 3-hydroxy-3-methyl-phthalide or its nuclear substitution product专利检索，专利查询，专利分析的服务。并且PURPOSE: To obtain the titled compound useful as an intermediate for a medicine effective against arteriosclerotic diseases and an agricultural chemical industrially advantageously, by reacting phthalic anhydride or its nuclear substitution product with malonic acid in the presence of a specific catalyst in a specified organic solvent under heating.
CONSTITUTION: A compound of formula I (R is lower alkyl, lower alkoxy, lower alkoxycarbonyl or carboxyl group; n is 0 or 1) is reacted with malonic acid in at least one solvent of a dialkylformamide, dialkyl sulfoxide or an aliphatic lower carboxylic acid in the presence of a metal belonging to Groups IA, IIA, IIB or VIII in the periodic table and at least one metal selected from manganese, copper and zinc as a catalyst under heating to give the titled compound of formula II industrially advantageously. The resulting compound is in the relation of tautomerism to the compound of formula III, and may have either structure depending on the conditions.
COPYRIGHT: (C)1980,JPO&Japio，下面是Preparation of 3-hydroxy-3-methyl-phthalide or its nuclear substitution product专利的具体信息内容。
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