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Preparation of 4-phenoxypyrimidine

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专利汇可以提供Preparation of 4-phenoxypyrimidine专利检索,专利查询,专利分析的服务。并且PURPOSE: To obtain the title high-purity compound in high yields available as herbicides, fungicides for agriculture and gardening, by reacting a di-or trihalogenopyrimidine with a phenol in a mixed solvent of water and a polar organic solvent in the presence of a base.
CONSTITUTION: A pyrimidine shown by the formula I (X is halogen; R
1 is halogen; R
2 is H, lower alkyl or alkoxy; with the proviso that R
2 is H when R
1 is H) is reacted with a phenol, e.g., o-cresol, shown by the formula II (R
3 WR
5 are H, lower alkyl, lower alkenyl, lower alkylthio; with the proviso that R
3 and R
4 form benzene or pyridine ring miscible with benzene ring, R
4 and R
5 do similarly) in a mixed solvent of water and a polar organic solvent, e.g., a water-acetone mixed solvent in the presence of a base, e.g., NaOH at -10W50°C to give the desired compound shown by the formula III. A mixing ratio of water to the organic solvent is 1:10W10:1.
USE: An intermediate for preparing an uns-2,4-bisphenoxypyrimidine compound available as fungicides for agriculture and gardening.
COPYRIGHT: (C)1980,JPO&Japio,下面是Preparation of 4-phenoxypyrimidine专利的具体信息内容。

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