| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 81 | Hash-based systems and methods for detecting, preventing, and tracing network worms and viruses | US10251403 | 2002-09-20 | US20030115485A1 | 2003-06-19 | Walter Clark Milliken |
| A system (126-129) detects transmission of potentially malicious packets. The system (126-129) receives packets and generates hash values corresponding to each of the packets. The system (126-129) may then compare the generated hash values to hash values corresponding to prior packets. The system (126-129) determines that one of the packets is a potentially malicious packet when the generated hash value corresponding to the one packet matches one of the hash values corresponding to one of the prior packets and the one prior packet was received within a predetermined amount of time of the one packet. The system (126-129) may also facilitate the tracing of the path taken by a potentially malicious packet. In this case, the system (126-129) may receive a message that identifies a potentially malicious packet, generate hash values from the potentially malicious packet, and determine whether one or more of the generated hash values match hash values corresponding to previously-received packets. The system (126-129) may then identify the potentially malicious packet as one of the previously-received packets when one or more of the generated hash values match the hash value corresponding to the one previously-received packet. | ||||||
| 82 | Method of treating helminthiasis by parenteral administration of sulfoxide derivatives of benzimidazoles | US769632 | 1977-02-17 | US4076828A | 1978-02-28 | Rudiger D. Haugwitz; Larry R. Cruthers |
| A method is provided for treating or inhibiting helminthiasis by parenterally administering sulfoxide derivatives of benzimidazoles having the structure ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl, R.sup.2 and R.sup.3 may be the same or different and are hydrogen or lower alkyl, R.sup.4 is cycloalkyl, and m is 0 to 3, n is 0 to 3, m + n being .ltoreq. 5. Pharmaceutical compositions for use in the above method are also provided. | ||||||
| 83 | Method of treating helminthiasis by parenteral administration of sulfoxide derivatives of benzimidazoles | US791828 | 1977-04-28 | US4076827A | 1978-02-28 | Rudiger D. Haugwitz; Larry R. Cruthers |
| A method is provided for treating or inhibiting helminthiasis by parenterally administering sulfoxide derivatives of benzimidazoles having the structure ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl, and R.sup.2 is hydrogen, lower alkyl, halogen, lower alkoxy or nitro. Pharmaceutical compositions for use in the above method are also provided. | ||||||
| 84 | Improvement in the method of protecting timber from destruction by worms, dry-rot | US232D | US232A | 1837-06-14 | ||
| 85 | Method of Treating a Tumor and Biodistribution of a Drug Delivered by Worm-Like Filomicelles | US12514988 | 2007-11-14 | US20100305201A1 | 2010-12-02 | Dennis E. Discher; Shenshen Cai; Yan Geng; Paul Dalhaimer |
| Provided are filomicelle nanocarrier systems for the controlled transport and bioselective delivery of encapsulatable, cytotoxic active agents contained therein, particularly anticancer agents. Further provided are methods for controlling destabilization of the filomicelle membrane and the resulting hydrolysis-triggered, controlled release of the active agent(s) encapsulated therein by controlling the blend ratio (mol %) of hydrolysable PEO-block copolymer of the hydrophilic component(s) and of the more hydrophobic PEO-block copolymer component(s), wherein bioselective release of the encapsulated cytotoxic agents is distributed intracellularly, and wherein lowered dosage of the drug was delivered to the non-tumor organs. Thus, the filomicelle system offers enhanced tumor-selective biodistribution of a drug, and a reduced toxicity of the encapsulated drug to other organs. | ||||||
| 86 | Method to prevent vulnerability to virus and worm attacks through instruction remapping | US10782672 | 2004-02-19 | US07493483B2 | 2009-02-17 | Gordon D. McIntosh |
| A method for processing instructions by a processing unit. An instruction set is dynamically set for the processing unit using a selected instruction map. The selected instruction map is selected as one being different from a normal instruction map for the processing unit. The instructions are processed at the processor using the instruction set. A set of authorized instructions are encoded using the selected instruction map. | ||||||
| 87 | Process for controlling and destroying pathogenic small creatures, in particular insects and worms | US09274906 | 1999-03-23 | US06197784B1 | 2001-03-06 | Rainer Fuchs; Michael Huss |
| Small creatures from the group of insects and worms which are pathogenic to humans, animals and plants can be controlled effectively by applying or introducing an aqueous percarboxylic acid solution containing one or more percarboxylic acids with 1 to 6 carbon atoms to surfaces and/or into water. A solution which contains peracetic acid and/or performic acid is preferably used. In the case of insects, the larvae of these are controlled in water using an application concentration of 1 to 5000 ppm of percarboxylic acid. | ||||||
| 88 | Method of combatting helminthiasis using nitro-furyl-acrylate derivatives | US61911056 | 1956-10-30 | US2890982A | 1959-06-16 | NATT MICHAEL P |
| 89 | Method and apparatus to prevent vulnerability to virus and worm attacks through instruction remapping | US12267681 | 2008-11-10 | US08117433B2 | 2012-02-14 | Gordon D. McIntosh |
| A method, apparatus, and computer instructions for processing instructions by a processing unit. An instruction set is dynamically set for the processing unit using a selected instruction map. The selected instruction map is selected as one being different from a normal instruction map for the processing unit. The instructions are processed at the processor using the instruction set. A set of authorized instructions are encoded using the selected instruction map. | ||||||
| 90 | Hash-based systems and methods for detecting, preventing, and tracing network worms and viruses | US10251403 | 2002-09-20 | US07328349B2 | 2008-02-05 | Walter Clark Milliken |
| A system (126-129) detects transmission of potentially malicious packets. The system (126-129) receives packets and generates hash values corresponding to each of the packets. The system (126-129) may then compare the generated hash values to hash values corresponding to prior packets. The system (126-129) determines that one of the packets is a potentially malicious packet when the generated hash value corresponding to the one packet matches one of the hash values corresponding to one of the prior packets and the one prior packet was received within a predetermined amount of time of the one packet. The system (126-129) may also facilitate the tracing of the path taken by a potentially malicious packet. In this case, the system (126-129) may receive a message that identifies a potentially malicious packet, generate hash values from the potentially malicious packet, and determine whether one or more of the generated hash values match hash values corresponding to previously-received packets. The system (126-129) may then identify the potentially malicious packet as one of the previously-received packets when one or more of the generated hash values match the hash value corresponding to the one previously-received packet. | ||||||
| 91 | System and method for using quarantine networks to protect cellular networks from viruses and worms | US11173861 | 2005-06-30 | US20070006312A1 | 2007-01-04 | Changhong Li; Zoltan Olah |
| A system and method for providing a quarantine network to address threats emanating from viruses and worms. A quarantine network quarantines an infected terminal's traffic from the normal traffic flow. During the quarantine period, all of the traffic is analyzed by a quarantine network component. Based upon the results of this analysis, the network can restrict the access of infected terminals to various services, as well as prevent other devices from becoming infected by blocking infected materials such as attachments from reaching their respective recipients. | ||||||
| 92 | Method and apparatus to prevent vulnerability to virus and worm attacks through instruction remapping | US10782672 | 2004-02-19 | US20050188171A1 | 2005-08-25 | Gordon McIntosh |
| A method, apparatus, and computer instructions for processing instructions by a processing unit. An instruction set is dynamically set for the processing unit using a selected instruction map. The selected instruction map is selected as one being different from a normal instruction map for the processing unit. The instructions are processed at the processor using the instruction set. A set of authorized instructions are encoded using the selected instruction map. | ||||||
| 93 | Method of treating helminthiasis by parenteral or topical administration of sulfoxide derivatives of benzimidazoles | US809150 | 1977-06-22 | US4076825A | 1978-02-28 | Rudiger D. Haugwitz; Larry R. Cruthers |
| A method is provided for treating or inhibiting helminthiasis by parenterally or topically administering sulfoxide derivatives of benzimidazoles having the structure ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl, and R.sup.2 is lower alkyl. Pharmaceutical compositions for use in the above method are also provided. | ||||||
| 94 | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses | US10417238 | 2003-04-17 | US07022737B2 | 2006-04-04 | Jonathan S. Stamler; Owen W. Griffith |
| Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth by administration of a manipulator of nitrosative stress to selectively kill or reduce the growth of the microbes or helminths causing the infection or of host cells infected with the microbes or of the pathologically proliferating mammalian cells. Novel agents include α-alkyl-S-alkyl-homocysteine sulfoximines wherein the α-alkyl contains 2 to 8 carbon atoms, and the S-alkyl contains 1 to 10 carbon atoms. Mammals in need of increased nitrosative stress defenses are treated, e.g., humans at risk for a stroke because of having had a transient ischemic attack, are treated. Treatments to increase nitrosative stress defenses include repeated administrations of low doses of manipullators of nitrosative stress so that subject treated has increased tolerance to nitrosative stress. Mammals are treated for protozoal infections by systemic administration of L-buthionine-S-sulfoximine and agent that increases nirtrosative stress. | ||||||
| 95 | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses | US10013455 | 2001-12-13 | US06608110B2 | 2003-08-19 | Jonathan S. Stamler; Owen W. Griffith |
| Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth by administration of a manipulator of nitrosative stress to selectively kill or reduce the growth of the microbes or helminths causing the infection or of host cells infected with the microbes or of the pathologically proliferating mammalian cells. Novel agents include &agr;-alkyl-S-alkyl-homocysteine sulfoxmines wherein the &agr;-alkyl contains 2 to 8 carbon atoms, and the S-alkyl contains 1 to 10 carbon atoms. Mammals in need of increased nitrosative stress defenses are treated, e.g., humans at risk for a stroke because of having had a transient ischemic attack, are treated. Treatments to increase nitrosative stress defenses include repeated administrations of low doses of manipulators of nitrosative stress so that the subject treated has increased tolerance to nitrosative stress. Mammals are treated for protozoal infections by systemic administration of L-buthionine-S-sulfoximine and agent that increases nitrosative stress. | ||||||
| 96 | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically, proliferating cells or to upregulate nitrosative stress defenses | US09361167 | 1999-07-27 | US06180824B2 | 2001-01-30 | Jonathan S. Stamler; Owen W. Griffith |
| Mammals are treated for infection or for conditions associated with pathologically proliferating mammalian cell growth (for example, certain cancers, restenosis, benign prostatic hypertrophy) by administration of a manipulator of nitrosative stress to selectively kill or reduce the growth of the microbes or helminths causing the infection or of host cells infected with the microbes or of the pathologically proliferating mammalian cells. Novel agents include &agr;-alkyl-S-alkyl-homocysteine sulfoximines wherein the &agr;-alkyl contains 2 to 8 carbon atoms, and the S-alkyl- contains 1 to 10 carbon atoms. In another invention herein, mammals in need of increased nitrosative stress defenses are treated, e.g., humans at risk for a stroke because of having had a transient ischemic attack, are treated. Treatments to increase nitrosative stress defenses include, for example, repeated administrations of low doses of manipulators of nitrosative stress so that the subject treated has increased tolerance to nitrosative stress. In still another invention, mammals are treated for protozoal infections by systemic administration of L-buthionine-S-sulfoximine and agent that increases nitrosative stress. | ||||||
| 97 | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses | US852490 | 1997-05-07 | US6057367A | 2000-05-02 | Jonathan S. Stamler; Owen W. Griffith |
| Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth (for example, certain cancers, restenosis, benign prostatic hypertrophy) by administration of a manipulator of nitrosative stress to selectively kill or reduce the growth of the microbes or helminths causing the infection or of host cells infected with the microbes or of the pathologically proliferating mammalian cells. Novel agents include .alpha.-alkyl-S-alkyl-homocysteine sulfoximines wherein the .alpha.-alkyl contains 2 to 8 carbon atoms, and the S-alkyl-contains 1 to 10 carbon atoms. In another invention herein, mammals in need of increased nitrosative stress defenses are treated, e.g., humans at risk for a stroke because of having had a transient ischemic attack, are treated. Treatments to increase nitrosative stress defenses include, for example, repeated administrations of low doses of manipulators of nitrosative stress so that the subject treated has increased tolerance to nitrosative stress. In still another invention, mammals are treated for protozoal infections by systemic administration of L-buthionine-S-sulfoximine and agent that increases nitrosative stress. | ||||||
| 98 | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses | US10417238 | 2003-04-17 | US20030207815A1 | 2003-11-06 | Jonathan S. Stamler; Owen W. Griffith |
| Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth (for example certain cancers, restenosis, benign prostatic hypertrophy) by administration of a manipulator of nitrosative stress to selectively kill or reduce the growth of the microbes or helminths causing the infection or of host cells infected with the microbes or of the pathologically proliferating mammalian cells. Novel agents include null-alkyl-S-alkyl-homocysteine sulfoximines wherein the null-alkyl contains 2 to 8 carbon atoms, and the S-alkyl-contains 1 to 10 carbon atoms. In another invention herein, mammals in need of increased nitrosative stress defenses are treated, e.g., humans at risk for a stroke because of having had a transient ischemic attack, are treated. Treatments to increase nitrosative stress defenses include, for example, repeated administrations of low doses of manipulators of nitrosative stress so that the subject treated has increased tolerance to nitrosative stress. In still another invention, mammals are treated for protozoal infections by systemic administration of L-buthionine-S-sulfoximine and agent that increases nitrosative stress. | ||||||
| 99 | PHARMACEUTICAL COMPOSITIONS WITH ANTHELMINTIC ACTIVITY, DOSAGE UNITS THEREOF AND METHOD FOR TREATING HELMINTHIASIS IN ANIMALS | EP84902000.0 | 1984-05-24 | EP0146573A1 | 1985-07-03 | BENNET, Eva-Maria "Jingara"; BRYANT, Christopher; BEHM, Carolyn, Anne |
| Compositions pharmaceutiques ayant une forte activité anthelmintique et comprenant I) la levamisole de formule (2) et IIa) des carbamates de benzimidazole substitué de formule (3), où R1 représente un anneau hétérocyclique à 5 ou 6 membres ou un radical -NHCO2R2, où R2 représente un alkyle; R3 représente un alkyle, ou un radical -NHCO2R2 ou un radical -XR4, où X représente O, CO, S, SO, SO2-O- ou -O-SO2- et R4 représente un groupe hydrocarbure ou un aryle substitué par des groupes alcoxy, allogènes ou alkyles qui sont à leur tour substitués par au moins un atome d'allogène, à condition que lorsque R1 se trouve en position 5 et R1 représente -NHCO2CH3 et X représente CO, R4 ne représente pas un phényle et à la condition supplémentaire qu'au moins l'un de R1 et R3 doit représenter le radical -NHCO2 alkyle, (IIb) des pro-médicaments ou (IIc) des sels d'addition acide non toxiques de ces carbamates de benzimidazole substitué ou des pro-médicaments. L'invention concerne également une unité de dosage d'une telle composition et un procédé pour traiter l'helminthiase chez les animaux en leur administrant une quantité effective d'une telle composition. | ||||||
| 100 | Hash-based systems and methods for detecting and preventing transmission of polymorphic network worms and viruses | US12762367 | 2010-04-18 | US08272060B2 | 2012-09-18 | Walter Clark Milliken; William Timothy Strayer; Stephen Douglas Milligan; Luis Sanchez; Craig Partridge |
| A system (200) detects transmission of potentially malicious packets. The system (200) receives, or otherwise observes, packets and generates hash values based on variable-sized blocks of the packets. The system (200) then compares the generated hash values to hash values associated with prior packets. The system (200) determines that one of the received packets is a potentially malicious packet when one or more of the generated hash values associated with the received packet match one or more of the hash values associated with the prior packets. | ||||||
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