| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 621 | 봉독을 함유하는 기능성 벌꿀의 제조방법 | KR1020110129423 | 2011-12-06 | KR1020130063097A | 2013-06-14 | 황현 |
| PURPOSE: A manufacturing method of functional honey containing bee venom is provided to select honey receiving container indicating content of bee venom according to condition or constitution of individual. CONSTITUTION: (a) Bee venom is collected at the collecting plate as bees flew to current line(4) emit bee venom by electric shock of power source supplied to current line. (b) Vee venom is collected by scratching bee venom or separating it with rocking tool. (c) Bee venom collected with honey is mixed through the mixer. (d) Mixed bee venom honey is stored and packed to the honey receiving container. (c) step of bee venom is weight%, is composed within 10~50% of honey. Bee venom of (c) step is coated at outer surface of honey pills molded with a manufacturing device including vacuum pump, cooling device, condenser, concentration tank, and heating means. | ||||||
| 622 | Device of collecting bee toxin | JP3710975 | 1975-03-27 | JPS51114273A | 1976-10-07 | KUMAKIRI MICHIMARU |
| PURPOSE: To collect honey, honey wax and honey milk, as well as to collect bee toxin in a state in which the bees are kept in the nest box. COPYRIGHT: (C)1976,JPO&Japio | ||||||
| 623 | 봉독 비누의 제조방법 및 상기 방법에 의해 제조된 봉독 비누 | KR1020140155896 | 2014-11-11 | KR1020160056031A | 2016-05-19 | 현대우 |
| 본발명은 (a) 증류수에봉독및 화분을넣고혼합한후, 여기에꿀, 로얄제리및 프로폴리스를혼합한혼합물을넣고혼합하여봉산물혼합물을준비하는단계; 및 (b) 비누베이스에열을가하여녹인후, 상기 (a)단계의봉산물혼합물, 꿀, 로즈마리오일, 라벤더오일, 천연향및 비타민 E를첨가하여혼합한혼합물을비누모양으로성형하는단계를포함하여제조하는것을특징으로하는봉독비누의제조방법및 상기방법으로제조된봉독비누에관한것이다. | ||||||
| 624 | 蜜蜂电子取毒器 | CN200920120266.4 | 2009-05-21 | CN201422321Y | 2010-03-17 | 张良华 |
| 本实用新型公开了一种蜜蜂电子取毒器，它包括底框，电极网、取毒板和脉冲发生器，底框的上表面布有电极网，电极网上盖有取毒板，该取毒板为玻璃取毒板。用本实用新型能大量直接获得较高纯度的蜂毒，而且伤蜂率较低。此外，本实用新型还具有携带使用方便、省电的特点。 | ||||||
| 625 | 一种蜜蜂毒液精馏装置 | CN201820783495.3 | 2018-05-24 | CN208372505U | 2019-01-15 | 缪婧 |
| 本实用新型公布了一种蜜蜂毒液精馏装置，属于精馏加工技术领域，包括第一精馏塔和第二精馏塔，第二精馏塔的顶部设有减压管，减压管的另一端连接循环水减压泵，第二精馏塔的外部侧面上方设有回收管，回收管的内端下方设有蜂窝孔溢流板。本实用新型首先将蜜蜂毒液从蒸发室的顶面外部设有的进料斗投入，然后开启蒸发室底部的电加热器进行升温，由于第二精馏塔的顶部设有减压管，减压管的另一端连接循环水减压泵，采用减压蒸馏的方式，能够有效地控制精馏温度，而且在精馏之前进行均质，提高了蜂毒的均匀度，解决了现有技术的蜜蜂毒液精馏装置在精馏过程中采用常压精馏，精馏温度较高，容易导致蜂毒失活的技术问题。 | ||||||
| 626 | 胡蜂取毒器 | CN201720739394.1 | 2017-06-23 | CN207100211U | 2018-03-16 | 廖箕禄; 邓月明 |
| 本实用新型公开了胡蜂取毒器，包括压板、压杆、导电网、纱网、承载板、电源和中空的箱体，所述箱体的顶板设有与压杆相适配的第一通孔，压板设于所述箱体内，压杆的一端贯穿第一通孔与压板相连，压杆的另一端裸露在箱体外；导电网、纱网和承载板由上至下依次设于箱体内并位于压板的下方，电源与导电网电连接；箱体的侧壁上设有进蜂口，进蜂口位于压板与导电网之间。用户可利用导电网同时刺激一群位于箱体内胡蜂，使胡蜂同时射出毒液，极大地提高了蜂毒的采集效率；由于取蜂毒的过程是在箱体内完成的，有效地避免胡蜂蜇人的情况的发生，保障了工作人员的安全；工作人员无需穿戴防护用品，让工作人员的操作更简便。 | ||||||
| 627 | 一种倒吸式活职蜂收集装置 | CN201420531949.X | 2014-09-17 | CN204168888U | 2015-02-25 | 郭云胶; 黄国忠; 汪景安 |
| 本实用新型公开了一种倒吸式活职蜂收集装置，包括收集室，所述的收集室两端设置顶盖和底盖，所述底盖分为两瓣，两者之间通过铰链连接，其中的一瓣固结于收集室底部，另外一瓣通过锁紧装置与收集室底部活动连接。本实用新型根据职蜂特有的特性设置，解决了传统的采用火烧死职蜂后再来收集，死掉的职蜂泡蜂毒酒，蜂毒酒的质量不能保证的问题。本实用新型采用在缓冲室内设置倒吸装置的结构，职蜂通过倒吸装置从大直径端进入倒吸装置的小直径端，而后通过小端的进口进入到收集内，就很难再从收集室里面出来，因此收集职蜂效果相当好。而且本实用新型的制作简单，制作成本低廉，完全通过手工就能制作出来。非常具有实用性和推广性。 | ||||||
| 628 | 봉독을 유효성분으로 함유하는 호흡기 염증성 질환 예방 및 치료용 약학조성물 | KR1020120031734 | 2012-03-28 | KR1020130109742A | 2013-10-08 | 신승헌; 박관규; 한상미; 김경현; 이우람 |
| PURPOSE: A pharmaceutical composition containing bee venom as an active ingredient for preventing and treating respiratory inflammation is provided to effectively suppress inflammation in the respiratory epithelial cells, caused by fungi and dust mites and to effectively prevent nasal cavity inflammation in an animal model with allergic rhinitis. CONSTITUTION: Bee venom prevents and treats respiratory inflammation and is freeze-dried for intranasal administration. A pharmaceutical composition for preventing and treating respiratory inflammation contains 0.00005-1 ug/ml of bee venom as an active ingredient. A method for determining the recommended dosage of a drug for preventing and treating respiratory inflammation comprises the steps of: isolating bee venom from Apis mellifera L. and freeze-drying the bee venom; applying the freeze-dried bee venom to nasal mucosal endothelial cells in various concentrations to measure the efficacy of the bee venom; treating an animal model with allergic rhinitis with the freeze-dried bee venom in various concentrations; and measuring treatment index and numerical value in respiratory inflammation by a conventional experimental method using blood and nasal cavity tissues collected from an experimental animal treated with the freeze-dried bee venom and determining the recommended dosage. | ||||||
| 629 | 봉독을 이용한 멜리틴의 분리방법 | KR1020060029773 | 2006-03-31 | KR100744755B1 | 2007-08-01 | 최석호; 권기록 |
| A purification method of melittin from bee venom is provided to inhibit allergy responses in bee venom therapy by removing PLA(phospholipase A2) causing allergy responses from melittin. The method for purification of melittin from bee venom comprises the steps of: extracting the bee venom from the bee's venom sac; solubilizing the bee venom in buffer, centrifuging the solution to remove a surface lipid layer and isolate the supernatant; subjecting the supernatant to gel filtration chromatography using a development solvent prepared by dissolving ammonium acetate in distilled water and regulating pH of the solution to pH 3.0-4.0 by adding acetic acid; subjecting the isolated melittin to gel filtration chromatography using hydrochloric acid solution as a development solvent to obtain a desalted fraction; and adding NaOH to the desalted faction to neutralize the fraction and freeze-drying the neutralized fraction. | ||||||
| 630 | 알러지 물질이 불활성화된 정제 봉독의 분리 방법 | KR1020140158540 | 2014-11-14 | KR1020160057662A | 2016-05-24 | 한상미; 여주홍; 홍인표; 우순옥; 김세건; 장혜리 |
| 본발명은 i) 정제봉독 1g을멸균증류수 50 내지 150 ml에희석시키는단계; ii) 상기희석된정제봉독액을항온수조에서 65 내지 85 ℃의 온도로 1시간내지 8시간동안중탕하는단계; iii) 상기중탕된정제봉독액을 0.45 μm 멤브레인필터로여과하여하청액을얻는단계; 및 iv) 상기하청액을동결건조하는단계;를포함하는포스포리파아제 A2 및히알루로니다아제가불활성화된것을특징으로하는정제봉독의분리방법에관한것이다. | ||||||
| 631 | 봉독을 함유하는 치주질환, 충치 예방 및 치료용 조성물 | KR1020100040282 | 2010-04-29 | KR1020110120732A | 2011-11-04 | 한상미; 이광길; 여주홍; 박관규; 장영채; 이양구 |
| PURPOSE: A composition containing bee venom for preventing and treating periodontal diseases is provided to ensure antibacterial activity and to suppress oral inflammation. CONSTITUTION: A composition for preventing and treating periodontal diseases contains bee venom as an active ingredient. A composition for preventing and treating dental caries contains the bee venom as an active ingredient. A composition for mouth cleansing contains the bee venom as an active ingredient. The bee venom suppresses Streptococcus mutans, Streptococcus sanguis, Porphyromonas Gingivalis, and Fusobacterium nucleatum. | ||||||
| 632 | 봉독을 포함하는 젖소 유방염 주입제의 약제학적 조성물 | KR1020080113917 | 2008-11-17 | KR1020100055025A | 2010-05-26 | 송영준; 김기동 |
| PURPOSE: A pharmaceutical composition of injection for bovine mastitis containing bee venom is provided to ensure antibacterial effect and to maintain a product in a stable state. CONSTITUTION: A composition of injection for bovine mastitis contains 0.03-0.12 weight% of bee venom having 40 wt% or more of melittin. The composition additionally contains 30-89.88 weight% of glycerin and 3-10 weight% of polyvinyl pyrrolidone. The bee venom is manufactured by collecting bee venom ingredient and freeze-drying. The glycerin is added to injection for mastitis as a safe solvent. | ||||||
| 633 | 一种用于治疗类风湿性关节炎的载多肽药物微针贴片 | CN202311266743.9 | 2023-09-28 | CN119700636A | 2025-03-28 | 孙逊; 杜广盛; 赵元豪; 熊坤 |
| 本发明公开了一种治疗类风湿性关节炎的微针透皮给药贴片及其制备方法，微针中含有活性药物成分蜂毒肽。本发明所述的聚合物微针可有效穿刺皮肤角质层进入表皮层，将储存在微针中的药物递送至皮肤组织中，极大提高药物经皮递送效率。动物实验表明，微针具有足够机械强度来穿刺皮肤，有效抑制了类风湿性关节炎动物模型的病理表现，展示了良好的治疗效果。本发明微针制备方法简便，有较好临床转化前景。 | ||||||
| 634 | 一种胡蜂毒活性肽Vb-MLP 12a及其制备方法和应用 | CN202310516903.4 | 2023-05-09 | CN118440149A | 2024-08-06 | 蒋林; 吴湧华; 吴倩嫦; 汪景安; 陈碧云; 汪永强 |
| 本发明公开了本发明提供一种胡蜂毒活性肽Vb‑MLP 12a及其制备方法和应用，属于生化药物制备技术领域。本发明以黑盾胡蜂蜂毒冻干粉为提取原料，采用制备型液相色谱仪一步法制备，运用高效液相色谱仪检测分析纯度达97％以上，MALDI‑TOF质谱仪分析分子量约为1554.9Da，结合LC‑MS/MS鉴定，Vb‑MLP 12a氨基酸序列为INWKGIAAMAKKLL。胡蜂毒肽类似物Vb‑MLP 12a具有显著促进小鼠巨噬细胞RAW264.7增殖活性，提示其在增强免疫功能等医学应用方面具有潜在的应用价值。 | ||||||
| 635 | 一种用于蜜蜂的电子取毒装置 | CN202410616164.0 | 2024-05-17 | CN118340118A | 2024-07-16 | 缪婧 |
| 本申请公开了一种用于蜜蜂的电子取毒装置，涉及蜂毒提取技术领域，包括：框架；设置在所述框架内的导电栅栏；位于所述导电栅栏下方的取样组件；设置在所述框架内的电控器件，所述电控器件与所述导电栅栏电连接；设置在所述框架内的玻璃，所述玻璃位于所述取样组件的下方；通过限位机构安装在所述框架上的堵板，所述堵板能够对所述取样组件和所述玻璃进行限位；封盖，所述封盖设置在所述框架上，以便于封堵所述电控器件，本申请具有安装和取样方便的特点。 | ||||||
| 636 | 一种抗衰老组合物及其应用 | CN202311427953.1 | 2023-10-31 | CN117137822B | 2024-02-13 | 黄毅; 阚洪玲; 邢海英; 王磊; 李锋; 钱令页 |
| 本发明公开了一种抗衰老组合物及其应用，属于美容肽技术领域。一种抗衰老组合物包括：美容肽和活性物质；美容肽选自蜂毒肽、棕榈酰二肽‑7、乙酰基四肽‑2和抗皱六肽中的至少2种，抗皱六肽为Ac‑Trp‑Phe(4‑Cl)‑Arg‑D‑Leu‑Ala‑His‑NH2；活性物质选自透明质酸钠、氨基化透明质酸钠、麦角硫因和γ‑氨基丁酸中的至少1种。本发明抗衰老组合物用成分之间能够发挥协同增效作用，通过提高基底胶原蛋白表达而发挥抗皱作用，同时抗衰老组合物对皮肤还具有优异的保湿效果，抗皱和保湿功效使得本发明组合物具有较强的抗衰老作用。 | ||||||
| 637 | 一种广谱高效的抗菌多肽APH143及其制备方法和应用 | CN202311142927.4 | 2023-09-06 | CN116874613B | 2023-11-17 | 孙周; 孔毅; 林志昊; 郑佳茵; 孙向阳; 龚勋 |
| 本发明公开了一种广谱高效的抗菌多肽APH143及其制备方法和应用，该抗菌多肽APH143的氨基酸序列为SEQ ID NO.1：LWKKFKLKKKFLWLWKKF‑NH2。本发明从天蚕素与蜂毒肽的杂合肽P18出发，通过构效关系的研究，获得非完美两亲性α‑螺旋抗菌肽APH143。本发明所制备的多肽APH143具有良好的体外广谱抗菌活性，对于肺炎克雷伯菌、鲍曼不动杆菌、金黄色葡萄球菌、铜绿假单胞菌具有较好的体外抗菌活性，并且稳定性较好。同时本发明制备所得的多肽APH143，原料来源易得，可以规模化生产，其在应用于治疗细菌和真菌感染性疾病方面具有潜在应用价值。 | ||||||
| 638 | 一种重组减毒沙门氏菌LH430及其制备方法和用途 | CN201811405595.3 | 2018-11-23 | CN109439686B | 2022-07-01 | 金天明; 李昕; 王小月; 李丹; 蓝肇煜; 孟佳丽; 尚翠玲; 林静; 高珂珂; 李小慧 |
| 本发明公开了一种重组减毒沙门氏菌LH430及其制备方法和用途，利用蜂毒肽MEL基因和肿瘤靶向肽RGD基因，将目的基因克隆到pMD‑18‑T载体中，线性化重组穿梭载体后构建重组真核表达载体pEGFP‑RGD‑MEL，将其转化至感受态LH430，构建了包含上述目的基因的重组减毒沙门氏菌LH430；用重组减毒沙门氏菌LH430侵染黑色素瘤细胞B16，使其表达RGD‑MEL基因；评价RGD‑MEL基因共表达的减毒沙门氏菌LH430对B16细胞的抑瘤效果。 | ||||||
| 639 | 一种治疗红斑狼疮的中药组合物及制备方法 | CN202111278309.3 | 2021-10-30 | CN113786455A | 2021-12-14 | 吕向东 |
| 本发明提出了一种治疗红斑狼疮的中药组合物及制备方法，涉及中药技术领域。一种治疗红斑狼疮的中药组合物，按重量份计，包括如下原料：马交儿5‑15份、柿叶2‑7份、蜂毒5‑10份、火把花2‑7份、密纹薄芝2‑5份、金银花7‑15份、甘草2‑9份、蒲公英5‑10份、黄连1‑5份、蝉蜕2‑7份、黄精5‑9份、川芎2‑7份、丹参1‑4份和玄参2‑7份。此中药组合物具有治疗效果好的优点。 | ||||||
| 640 | 一种提高光动力和免疫治疗的纳米粒子及其制备方法 | CN201910886933.8 | 2019-09-19 | CN110548142A | 2019-12-10 | 易昌凤; 黄漂 |
| 本发明提供了一种提高光动力和免疫治疗的纳米粒子及其制备方法，包括以下步骤：称取牛血清蛋白溶于去离子水中,超声后搅拌，再取适量光敏剂二氢卟吩e6加入其中，避光搅拌过夜后，经离心、洗涤，得到BSA-Ce6纳米粒子，将其溶解于去离子水中，超声后搅拌，加入适量MLT，再搅拌，离心，洗涤，透析后得到提高光动力和免疫治疗的纳米粒子。本发明采用的制备方法使用蜂毒肽MLT，不仅增强了光动力治疗，而且增强了免疫治疗的效果。 | ||||||
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