| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | Use of essential oils to increase bioavailability of orally administered pharmaceutical compounds | US19936 | 1998-02-06 | US6121234A | 2000-09-19 | Leslie Z. Benet; Vincent J. Wacher; Reed M. Benet |
| A method for increasing bioavailability and reducing inter- and intra-individual variability of an orally administered hydrophobic pharmaceutical compound, which comprises orally coadministering the pharmaceutical compound to a mammal in need of treatment with the compound with an essential oil or essential oil component in an amount sufficient to provide bioavailability of the compound in the presence of the essential oil or essential oil component greater than bioavailability of the compound in the absence of the essential oil or essential oil component, wherein the essential oil or essential oil component has an activity of at least 10% inhibition at a concentration of 0.01 wt. % or less in an assay that measures conversion of cyclosporine to hydroxylated products using an assay system containing 250 .mu.g rat liver microsomes, 1 .mu.M cyclosporine, and 1 mM reduced nicotinamide adenine dinucleotide phosphate (NADPH) in 1 ml of 0.1 M sodium phosphate buffer, pH 7.4. | ||||||
| 2 | Inhibition of abnormal accumulation of extra-cellular matrices | US877351 | 1997-06-17 | US6068845A | 2000-05-30 | Hiroe Aoki; Eijiro Hara; Tetsuji Hirao |
| This invention provides a pharmaceutical preparation or cosmetic, and a method for effectively inhibiting the abnormal accumulation of extra-cellular matrices. In addition, a method for preventing or treating a disease resulting from the abnormal accumulation of extra-cellular matrices is also disclosed. The pharmaceutical preparation or cosmetic contains as an effective ingredient at least one substance selected from the group consisting of the extract of a plant belonging to the genus Artemisia, the genus Forsythia, the genus Sophorak the genus Pheutn the genus GI rhiza, the genus Arctium, the genus Anemarrhena, the genus Aralia, the genus Anelicia, the genus Akebia or the genus Atractylodes, the genus Akebia or the genus Atractilodes, malotilate, 2,2'-dipyridyl and o-phenanthroline. | ||||||
| 3 | Use of essential oils to increase bioavailability of oral pharmaceutical compounds | US478207 | 1995-06-07 | US5716928A | 1998-02-10 | Leslie Z. Benet; Vincent J. Wacher; Reed M. Benet |
| A method for increasing bioavailability and reducing inter- and intra-individual variability of an orally administered hydrophobic pharmaceutical compound, which comprises orally administering the pharmaceutical compound to a mammal in need of treatment with the compound concurrently with an essential oil or essential oil component in an amount sufficient to provide bioavailability of the compound in the presence of the essential oil or essential oil component greater than bioavailability of the compound in the absence of the essential oil or essential oil component, wherein the essential oil or essential oil component has an activity of at least 10% inhibition at a concentration of 0.01 wt. % or less in an assay that measures conversion of cyclosporine to hydroxylated products using an assay system containing 250/.mu.g rat liver microsomes, 1.mu.M cyclosporine, and 1 mM reduced nicotinamide adenine dinucleotide phosphate (NADPH) in 1 ml of 0.1M sodium phosphate buffer, pH 7.4. | ||||||
| 4 | Method for improving amoxicillin absorption in mammals by administering the amoxicillin to the mammal in combination with Rosa roxburghii, Artemisiae argyi folium and/or Brassica oleracea var. capitata L. | US438503 | 1995-05-10 | US5628998A | 1997-05-13 | Seiichi Araki; Mamoru Suzuki; Masatoshi Fujimoto; Tadashi Ueki |
| A method for improving amoxicillin absorption in mammals such as pigs by administering the amoxicillin to the mammal in combination with one or more of the following plant substances: Rosa roxburghii, Artemisiae argyi folium and Brassica oleracea var. capitata L. The plant substance is administered in its natural state, dried, or as an extract. | ||||||
| 5 | Pharmaceutical composition comprising Rosa roxburghii, Artemisiae argyi folium and Brassica oleracea var. capitata L. used to reduce the symptoms of diarrhea | US433312 | 1995-05-03 | US5556625A | 1996-09-17 | Seiichi Araki; Mamoru Suzuki; Masatoshi Fujimoto; Tadashi Ueki |
| A method of reducing the symptoms of diarrhea by administering to an animal a composition containing Rosa roxburghii, Artemisiae argyi folium, and Brassica oleracea var. capitata L. | ||||||
| 6 | Pharmaceutical compositions for reducing hyperlipidemia and platelet-aggregation | US905554 | 1986-09-08 | US4842859A | 1989-06-27 | Yaguang Liu |
| The new pharmaceutical compositions and processes are provided for reducing both hyperlipidemia and platelet-aggregation (PHP).The fine-PHP is composed of following ingredients: Scoparone or Aurapten, Curcumin, Ferulic Acid, Yejuhua-flavonoid and additive ingredient--fish oil. The compositions are nontoxic. | ||||||
| 7 | Method of treating alimentary canal ulcers with sagebrush oil | US4148060 | 1960-07-08 | US3133860A | 1964-05-19 | ALBERT SHERMAN |
| 8 | Improvement in medical compounds or ointments | US149853D | US149853A | 1874-04-21 | ||
| 9 | Improvement in medicinal compounds to cure hog-cholera | US31723D | US31723A | 1861-03-19 | ||
| 10 | Herbal compositions for treatment of gastrointestinal disorders | US275653 | 1999-03-24 | US6039954A | 2000-03-21 | Yu Long Yu; Alan Bensoussan |
| Herbal formulations are disclosed for the treatment of gastrointestinal disorders, in particular Irritable Bowel Syndrome (IBS). The compositions are formulated preferably with powdered herbs however combined extracts of herbs are also contemplated. | ||||||
| 11 | Composition and method for treating premenstrual syndrome | US27147 | 1998-02-20 | US5968518A | 1999-10-19 | Laurie Pike |
| An herbal composition is disclosed comprising as active ingredients chickweed, yarrow, wormwood, motherwort, pennyroyal, and dandelion in a vehicle of olive-oil and beeswax. The composition alleviates cramps, aches and pains, such as those associated with premenstrual syndrome. | ||||||
| 12 | Process for the simultaneous production of artemisnin and essential oil from the plant artemisia annua | US944865 | 1997-10-06 | US5955084A | 1999-09-21 | Dharam Chand Jain; Sudeep Tandon; Rajendra Singh Bhakuni; Mohammed Shafique Siddique; Atul Prakash Kahol; Ram Prakash Sharma; Sushil Kumar; Asish Kumar Bhattacharya |
| This invention relates to a novel process for the dual production of essential oil and artemisinin from the plant Artemisia annua, said process comprising extracting the plant with hexane, partitioning the hexane extract between hexane and acetonitrile, hydrodistillation of hexane residue and Marc to yield essential oil, further fractionation of acetonitrile solvent between hexane-benzene mixture to remove artemisinic acid, chromatographing of the acetonitrile phase to produce substantially pure artemisinin, the artemisinic acid is reduced to obtain dihydro artemisinic acid which is then oxidised in a single step to form artemisinin. | ||||||
| 13 | Antimicrobial compositions | US832821 | 1997-04-04 | US5939050A | 1999-08-17 | Lokanathan M. Iyer; James R. Scott; Douglas F. Whitfield |
| Antimicrobial compositions comprising at least two antimicrobial agents exhibit reduced MIC values relative to the MIC for the agents making up the combination when measured alone. The compositions are useful as therapeutic agents such as in oral hygiene products. | ||||||
| 14 | Method of immunopotentiating and protecting an animal from E. coli infections using a combination of Rosa roxburghii, Artemisiae argyi folium and Brassica oleracea var. capitata L. | US333079 | 1994-11-01 | US5556624A | 1996-09-17 | Seiichi Araki; Mamoru Suzuki; Masatoshi Fujimoto; Tadashi Ueki |
| A method for immunopotentiating and protecting an animal from an infection caused by E. coli is described. The method comprises administering a composition containing Rosa roxburghii, Artemisiae argyi folium, and Brassica oleracea var. capitata L. to the animal. | ||||||
| 15 | Medical compound | US460611D | US460611A | 1891-10-06 | ||
| 16 | Insecticide | US436848D | US436848A | 1890-09-23 | ||
| 17 | Improvement in medical compounds or bitters | US149573D | US149573A | 1874-04-14 | ||
| 18 | Improvement in medical compounds or liniments | US124910D | US124910A | 1872-03-26 | ||
| 19 | Improvement in medical compound | US106573D | US106573A | 1870-08-23 | ||
| 20 | Improved liniment for rheumatism | US82696D | US82696A | 1868-10-06 | ||
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